tbuckley/cabot-search huggingface dataset:
Abstract 270: Loss of S100A1 Protein Negatively Impacts Glucose Metabolism and Energy Homeostasis in Cardiomyocytes
Authors: Fadwa Abdalla, Andrea Schneider, Hugo A.Katus, Martin Busch, Patrick Most
Journal: Circulation Research (2019)

Introduction: As a true metabolic omnivore, the heart is able to utilize different substrates for energy production. In the hypertrophied and early failing state, cardiac muscle leans towards glucose as a major carbon substrate to meet its energetic demand. Given that S100A1 gene therapy reverses the compromised energetic balance of the failing heart, we were interested in determining the specific role of the EF-hand calcium sensor S1001A1 in cardiomyocyte energy metabolism. Methods and results: To study metabolic changes in response to different carbon substrates, we used neonatal rat ventricular cardiomyocytes (NRVMs), which were subjected to electrical stimulation (2Hz) in culture and adenoviral-mediated anti-S100A1 shRNA silencing or scr-shRNA, and either fed with glucose, oleate or lactate only for 24hrs. Of note, lack of S100A1 expression only impaired energy metabolism of cardiomyocytes in response to glucose as reflected by a significantly decreased ATP content and subsequently enhanced AMP/ATP and p-AMPK/AMPK ratios with consecutive elevated p-ACC/ACC and Glut4 protein levels. In contrast, energy metabolism appeared to remain normal in response to oleate in S100A1-deprived cells. Targeted metabolomics yielded a tremendous decrease in glucose-6-phosphate levels as the first key step in glucose metabolism despite enhanced AMPK activation in glucose-fed S100A1-defiecient cardiomyocytes. Conclusion: Our novel in vitro data indicate that S100A1 protein may be crucial for cardiomyocytes to meet their energetic demand when glucose is the major substrate. Since the latter becomes the preferred substrate for functionally compromised heart over fatty acids, lack of S100A1 expression - as a result of fetal gene reprogramming - most likely impairs the ability of the heart to sufficiently utilize glucose to meet its energetic demand. These data shed new mechanistic light on the sustained therapeutic efficacy of S100A1 gene therapy of heart failure where S100A1 may be a key factor enabling the heart to sufficiently use glucose to reverse its compromised energetic state. Further studies answering these pressing questions are underway for an informed design of a best-case patient enrollment scenario for a first-in-men clinical study.
A Sequence Variation in the Promoter Region of PTPN22 Gene Predicts Relapse After HLA-Fully-Matched Unrelated Bone Marrow Transplantation for Hematologic Malignancies
Authors: Luis J. Espinoza, Akiyoshi Takami, Katsuya Nakata, Makoto Onizuka, Yasuo Morishima, Takahiro Fukuda, Yoshihisa Kodera, Shinji Nakao
Journal: Blood (2011)
Leukocytosis Is Associated with End Organ Damage in Chronic Myelomonocytic Leukemia (CMML) and Can be Mitigated with Cytoreductive Therapy
Authors: Anthony Hunter, Najla Al Ali, Anne Mai, Chetasi Talati, Andrew Kuykendall, Kendra L. Sweet, David A Sallman, Jeffrey E. Lancet, Alan F. List, Rami S. Komrokji, Eric Padron
Journal: Blood (2018)
Rituximab Plus GM-CSF for Patients with Chronic Lymphocytic Leukemia.
Authors: Alessandra Ferrajoli, Susan M. O’Brien, Stefan H. Faderl, William G. Wierda, Farhad Ravandi-Kashani, Brandi O’Neal, Ellen Schlette, Maher Albitar, Hagop M. Kantarjian, Michael J. Keating
Journal: Blood (2005)
Maximizing the Outcomes of Breast Cancer Prevention
Authors: Katrina A. Armstrong
Journal: JAMA Internal Medicine (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Transfusion Transmitted Viral Infections in Transfusion Dependent Patients with Thalassemia in Turkey: A Multicenter Study.
Authors: Meral Sonmezoglu, Yesim Aydinok, Duran Canatan, Meral Turker, Huseyin Gulen, Gulersu Irken, Zeynep Karakas, Zumrut L. Uysal, Gonul Aydogan, Ozcan Cengiz, Cetin Timur, Hilmi Apak, Cengiz Canpolat, Mahmut M. Bayik
Journal: Blood (2004)
Red Blood Cell and Platelet Phenotype Prediction from Whole Genome Sequencing in 621 Sickle Cell Disease Patients: Correlation with Alloimmunization History, Serology and Other Genotyping Methods
Authors: Celina Montemayor Garcia, Julie K. Weisman, Divya Gandla, James Owen Long, Clifton Lee Dalgard, Mehdi Pirooznia, Harvey Klein, Swee Lay Thein
Journal: Blood (2018)
Household air pollution-related lung disease: protecting the children
Authors: Peter P Moschovis, Patricia L Hibberd
Journal: Thorax (2019)

Nearly 3 billion people worldwide cook and heat their homes using biomass fuels, primarily in low and middle-income countries.1 Smoke from biomass fuel combustion contains a combination of gases, particulate matter and volatile organic compounds that is particularly harmful to the developing lungs of children.2 Over time, chronic exposure to household air pollution results in mucus hypersecretion, emphysema and bronchiolar fibrosis,3 and exposure to household air pollution is a well-described risk factor for both acute and chronic respiratory disease.4–6 

The settings in which biomass smoke exposure is most common are also settings in which there is a high prevalence of reduced lung function.7 8 A recent study of 2000 primarily non-smokers in urban Malawi found a >40% rate of abnormal lung function (primarily reduced forced vital capacity (FVC)),9 and the largest published spirometry study in Uganda reported that 16% of adults over age 30 years had spirometry-confirmed chronic obstructive pulmonary disease (COPD).10 There is increasing evidence that reduced lung function begins early in life11–15; therefore, efforts to understand and prevent chronic respiratory disease must focus on modifiable risk factors that affect lung development in infancy and early childhood.16 17 Several studies have previously measured lung function among children in sub-Saharan Africa,18–21 but no prior study has reported the effect of a cookstove intervention on lung function in African children. Despite a number of cookstove intervention trials, there remains a lack of conclusive evidence regarding the benefit of cookstove interventions on lung health.22 

In this issue of Thorax , Rylance et al report the results of …
Learning Curves and the Challenges of Adopting New Surgical Techniques
Authors: Laura A. Graham, Mary T. Hawn
Journal: JAMA Network Open (2019)

Daniel A. Caroff, MD, MPH; Christina Chan, MPH; Ken Kleinman, ScD; Michael S. Calderwood, MD, MPH; Robert Wolf, BTS; Elizabeth C. Wick, MD; Richard Platt, MD, MSc; Susan Huang, MD, MPH
Does Presence of Persistent Molecular Mutations Matter in AML Patients Undergoing Allogeneic Stem Cell Transplant?
Authors: Sangmin Lee, Jingmei Hsu, Yassine Tahri, Zhengming Chen, Tsiporah B. Shore, Ellen K. Ritchie, Usama Gergis, Pinkal Desai, Sebastian A. Mayer, Michael Samuel, Adrienne A. Phillips, Melissa M. Cushing, Gail J. Roboz, Koen Van Besien
Journal: Blood (2018)
Quantitative Assessment of Indoleamine 2,3-Dioxygenase (IDO) Expression at Diagnosis Predicts Clinical Outcome in Patients with Acute Myeloid Leukemia Undergoing Allogeneic Stem Cell Transplantation
Authors: Sarah Parisi, Simone Ragaini, Darina Ocadlikova, Mariangela Lecciso, Giovanni Marconi, Stefania Paolini, Cristina Papayannidis, Maria Chiara Abbenante, Chiara Sartor, Giovanni Martinelli, Emanuela Ottaviani, Francesca Bonifazi, Michele Cavo, Antonio Curti
Journal: Blood (2018)
Effective Stimulant Dosing in Attention-Deficit/Hyperactivity Disorder
Authors: Jonas Eric Dravland
Journal: JAMA Pediatrics (2019)

To the Editor Ching et al1 are commended for their careful and insightful study of stimulant dosing and titration and analysis of current practice. The commonly accepted notions of an evidence basis for describing maximal doses of stimulants are refuted.
Abstract 10613: Symptomatic Human Immunodeficiency Virus Infected Patients Receive Less Aggressive Revascularization Management After Acute Coronary Syndrome, a 5-year Nationwide Analysis
Authors: Claire Huang Lucas, Lingling Wu, Bing Yue, Nikhil Bachoo, Robert Abed, Joshua Berookhim, Xin Wei, Eyal Herzog
Journal: Circulation (2019)

Introduction: Cardiovascular disease is a leading cause of morbidity and mortality in human immunodeficiency virus (HIV) infected adults, and should be managed more aggressively.Prior studies highlighted treatment disparities for Acute Coronary Syndrome (ACS) among HIV patients. This study aims at examining these disparities with the latest large cohort data. Hypothesis: HIV patient with ACS are as likely to receive cardiac revascularization related procedures compared to control group. Methods: We reviewed the Nationwide Inpatient Sample from 2013 to 2016 to identify patients with diagnosis of ACS (ST-elevation and non ST-elevation myocardial infarction, and unstable angina) to compare rates of cardiac procedures (Catheterization, Percutaneous Coronary Intervention - PCI - and Coronary Artery Bypass Graft - CABG) among groups of population of interest (control, asymptomatic HIV, symptomatic HIV). Results: Overall, 515,016 patients with primary diagnosis of ACS where identified and among them 2066 (0.40%) of ACS patients had diagnosis of HIV (asymptomatic and symptomatic). Multivariate regression analysis showed statistically significant lower procedural rates for catheterization (OR: 0.62, 95% CI: [0.52, 0.73]), PCI (OR: 0.80, 95% CI: [0.67, 0.96]) and CABG (OR: 0.70, 95% CI: [0.52, 0.93]) in symptomatic HIV compared to control group. For asymptomatic HIV patient group, no significant change of procedural rates were found compared to control group for catheterization, PCI and CABG (respectively OR: 0.90, 95% CI: [0.78, 1.05], OR: 1.13, 95% CI: [1.00, 1.26] and OR: OR: 0.87, 95% CI: [0.72, 1.04]). Conclusions: Analysis shows a treatment disparity for ACS for symptomatic HIV patients only as symptomatic HIV affected patients received less aggressive catheterization and revascularization management after ACS, compared to control group. However, this effect was not present for the asymptomatic HIV patient group.
Induction of house officers
Authors: B S Baker
Journal: BMJ (1992)

Nursing time must be allowed for cleaning and disinfecting sigmoidoscopes during a list, and more than one sigmoidoscope may be required.Nursing time is required for correctly maintaining sigmoidoscopes and disinfection equipment weekly to keep all equipment in good condition and prevent cross infection.Sigmoidoscopy can be performed by general practitioners, but they must recognise that it is costly with important health and safety aspects.
Prognosis factors and colorectal cancer survival at Oncologos del Occidente from Colombia, South America.
Authors: Jose Arnoby Chacon Cardona, Carlos Raul Villegas Mejia, Tomas Sanchez Villegas
Journal: Journal of Clinical Oncology (2013)

e14692 Background: Colorectal cancer is the fourth cause of cancer in the United States and the third cause of mortality in the same country. In Colombia, it is the fourth most common cancer and the fifth cause of death. Methods: 5,500 medical records of patients suffering from colorectal cancer were analyzed in a study of a retrospective phase in Oncologos del Occidente a Private Cancer Center from January 1995 to September 2005. 771 out of these patients correspond to gastrointestinal tumours, and 351 out of them with a diagnosis of colorectal cancer in order to identify the main prognosis factors described on the medical literature and to illustrate their behaviour regarding the survival of the patients suffering from colorectal cancer in our region. Results: Obstruction was observed on 33.7%; ulceration on 20.3%; lympho-neuro-vascular invasion on 7.5%; perforation on 2.1%; clinical state T4 on 2.3%; positive surgical margins on 1.8% and poor differentiation on 4.6%. The survival to 5 years to those patients showing perforation was 66.7% (IC 95%: 28.9-100); 79.9 on tumours T4 (IC 95% : 52.3-100); 62.5% on positive margins (IC 95%: 20-100); 42.4% on poor differentiated tumours (IC 95% :0-85), 50% out of this correspond to colon cancer and 34% to rectal cancer; 51.2% on obstruction (IC 95% :38.9-63.4); 71,9% on lympho-neuro-vascular invasion (IC 95% :52.6-91.1) and 63% on ulcerated tumour (IC 95%: 49-76.9) . Conclusions: Survival calculated in months can be correlated with number of adverse prognostic factors present (Table). [Table: see text]
Inhibition of Unc-51-like Kinase 1 (ULK1) with Novel Small Molecular Inhibitor MRT68921 Preferentially Induces Apoptosis and Autophagy in FLT3-ITD- Mutated Acute Myeloid Leukemia
Authors: Jieun Jang, Hoi-kyung Jeung, So-Young Seol, Haerim Chung, Yu Ri Kim, June-Won Cheong, Yoo Hong Min
Journal: Blood (2018)
Abstract 15468: Acute Effect of Catheter Ablation Therapy on Blood Pressure in Patients with Atrial Fibrillation
Authors: Seigo Yamashita, Teiichi Yamane, Seiichiro Matsuo, Mika Hioki, Ryohsuke Narui, Shin-ichi Tanigawa, Keiichi Inada, Taro Date, Michihiro Yoshimura
Journal: Circulation (2012)

Background: Previous studies demonstrated that the left atrial (LA) ablation influenced the autonomic tone by ablating ganglionated plexus, resulting in the increase of heart rate (HR) and reductio...
Impact of Cumulative Dose of Carfilzomib in Combination with Lenalidomide and Desamethasone in Relapsed Refractory Myeloma Patients: A Retrospective Real Life Survey of the Sicilian Myeloma Network
Authors: Concetta Conticello, Enrica Antonia Martino, Vittorio Del Fabro, Giuseppe Sapienza, Valeria Calafiore, Bruno Garibaldi, Salvatore Innorcia, Marina Parisi, Emilia Cotzia, Ugo Consoli, Massimo Poidomani, Cinzia Maugeri, Donato Mannina, Vanessa Innao, Maurizio Musso, Clotilde Cangialosi, Stefania Tringali, Melania Carlisi, Giuseppe Salvatore Longo, Alessandra Romano, Francesco Di Raimondo
Journal: Blood (2018)
ALchemy - A Large Prospective ‘Real World' Study of Chemotherapy in AL Amyloidosis
Authors: Thirusha Lane, Lisa Rannigan, Darren Foard, Ashutosh Wechalekar, Simon Gibbs, Jennifer Pinney, Christopher P Venner, Sanjay Banypersad, Helen Lachmann, Philip N Hawkins, Julian D Gillmore
Journal: Blood (2011)
Hyperangiotensinemia Induces Stem Cell/Progenitor Mobilization and De-Adhesion From BM Endothelial Cells Through AT2R Signaling and Inhibition of RhoA Activity
Authors: Kyung-Hee Chang, Ramesh C Nayak, Katie Bezold, Ashley Ficker, Swarnava Roy, Xuan Zhou, Megan Pirman, Susan Dunn, Yi Zheng, Punam Malik, Jose A. Cancelas
Journal: Blood (2012)
Increasing compliance of an oral oncolytic program in a multi-location practice.
Authors: Amita Patel, Shannon Woerner, Tina Flocco, Rachel Carroll, Ellen Shander
Journal: Journal of Clinical Oncology (2019)

267 Background: Over the past two decades the rise in number of oral oncolytics has significantly changed the landscape of cancer treatment. Although these medications offer patients the convenience of home administration, they pose different challenges. Two examples are adherence and education of associated toxicities. In an ongoing effort to provide quality cancer care, the Central Jersey Division of Regional Cancer Care Associates (CJD RCCA) has reconstructed its oral oncolytic program. Methods: In 2016 the CJD of RCCA developed an oral oncolytic program to educate patients on how to safely manage their medications. After the provider sent the prescription, a flowsheet is entered into the EMR, triggering the chemotherapy teaching session and appropriate follow up visits. During this visit patients are provided drug specific educational sheets which include lab monitoring, common adverse effects, and calendars to document adherence. Due to failure of entering flowsheets into the EMR, patients lost to scheduling while waiting for medication delivery, or patient refusal of teaching, compliance remained low. The program was modified to include running a daily report to identify all new oral oncolytic prescriptions. Schedulers are immediately calling patients to schedule a teaching session. A field in the EMR was created to document “patient refusal”. By making these improvements, CJD RCCA has increased compliance along with upholding quality care for patients receiving oral oncolytics. Results: Since re-structuring the program the RCCA CJD APNs have performed teaching on 124 of 172 (72%) patients from January to May of 2019. This is compared to only 79 of 144 (54%) in all of 2018. Of the patients identified in 2019 30 refused, 13 were completed by the physician, and 5 expired. This dramatic rise of 18% is largely due to running the daily oral oncolytic reports and entering the flowsheet into the EMR. Conclusions: Patient compliance has increased by identifying new patients and prompt enrollment into the program. It provides them the tools to safely navigate through treatment. At CJD RCCA, the oral oncolytic program is vital to ensuring positive clinical outcomes for these patients.
Hemostatic Effect of the Combination of Factor VIII Concentrate with Tranexamic Acid (TXA) in the Prophylactic Setting in Severe Hemophilia a
Authors: Maissaa Janbain, Nathalie Enjolras, Jean-Claude Bordet, Radu Bolbos, Cindy A. Leissinger, Yesim Dargaud
Journal: Blood (2018)
Abstract 350: Bcl-xL-Ser14 Phosphorylation is Critical for Compensatory Cardiac Hypertrophy
Authors: Michinari Nakamura, Nadezhda Fefelova, Tong Liu, Shohei Ikeda, Peiyong Zhai, Dominic P Del Re, Hong Li, Lai-Hua Xie, Junichi Sadoshima
Journal: Circulation Research (2019)

Cardiac hypertrophy is an adaptive response at least initially since it reduces wall stress. Phosphorylation of Bcl-xL at Serine (Ser) 14, which dissociates Bcl-xL from Bax and promotes apoptosis, is increased in the heart within one hour after transverse aortic constriction (TAC)-induced pressure overload (PO). Here, we investigated how the increased Ser14-phosphorylation affects hypertrophy during PO. The Bcl-xL knock-in (KI) mice, in which Ser14 was replaced with Ala (Ser14Ala), exhibited a significantly greater mortality than wild-type (WT) mice (p=0.001) after TAC, with elevated end diastolic pressure (LVEDP, 34.6 vs 16.5 mmHg, p&lt;0.05), impaired systolic function (EF, 38.2% vs 67.5%, p&lt;0.001), and increased fibrosis (1.6-fold, p&lt;0.001). The level of apoptosis was similar between the KI and WT mice one week after TAC, as assessed by TUNEL staining. The KI mice showed less cardiomyocyte and cardiac hypertrophy (cardiomyocyte size, 0.71-fold; heart weight/tibia length, 0.88-fold, both P&lt;0.001). Adult cardiomyocytes isolated from the KI mice two days after TAC showed significantly lower contractility compared to those isolated from WT mice (0.32-fold, p&lt;0.001). Mechanistically, gene set enrichment analysis using the RNA-seq data obtained from one-day TAC hearts showed that ion channel activity-related gene sets enriched in WT mice are downregulated in the KI mice. In line with this result, angiotensin II (Ang II) increased Ser14-phosphorylation and cytosolic Ca 2+ level in WT-MEFs in vitro , whereas MEFs isolated from the KI mice showed a significantly lower elevation of cytosolic Ca 2+ against Ang II. Proteomics analysis showed that Ankyrin, an anchoring protein that targets and stabilizes ion channels on the membrane, interacts with endogenous Bcl-xL in the heart. Taken together, these data suggest that phosphorylation of Bcl-xL at Ser14 is critical for augmenting Ca 2+ release from the sarcoplasmic reticulum by modulating the ion channel activity in part via Ankyrin against PO or AngII, thereby developing compensatory hypertrophy and maintaining contractile function. Our findings indicate that increasing the Bcl-xL-Ser14 phosphorylation during acute phase PO could be a potential therapeutic strategy for maintaining cardiac function.
Genetics of forced vital capacity: genome-wide association study meta-analysis and follow-up identifies six new loci
Authors: Daan Loth, María Artigas, Sina Gharib, Louise Wain, Nora Franceschini, Beate Koch, Tess Pottinger, Albert Smith, Qing Duan, Chris Oldmeadow, Mi Lee, Alan James, Jennifer Huffman, Veronique Vitart, Adaikalavan Ramasamy, Nicholas Wareham, Jaakko Kaprio, Xin-Qun Wang, Holly Trochet, Mika Kahonen, Claudia Flexeder, Eva Albrecht, Lorna Lopez, Kim de Jong, Bharat Thyagarajan, Alexessander Couto Alves, Stefan Enroth, Ernst Omenaas, Peter Joshi, Tove Fall, Ana Vinuela, Lenore Launer, Laura Loehr, Myriam Fornage, Li Guo, Jemma Wilk, Wenbo Tang, Ani Manichaikul, Lies Lahousse, Tamara Harris, Kari North, Alicja Rudnicka, Jennie Hui, Xiangjun Gu, Thomas Lumley, Alan Wright, Nicholas Hastie, Susan Campbell, Rajesh Kumar, Isabelle Pin, Robert Scott, Kirsi Pietilainen, Ida Surakka, Yongmei Liu, Elizabeth Holliday, Holger Schulz, Joachim Heinrich, Gail Davies, Judith Vonk, Mary Wojczynski, Anneli Pouta, Asa Johansson, Sarah Wild, Erik Ingelsson, Fernando Rivadeneira, Henry Volzke, P Hysi, Gudny Eiriksdottir, Alanna Morrison, Jerome Rotter, Wei Gao, Dirkje Postma, Wendy White, Stephen Rich, Albert Hofman, Thor Aspelund, David Couper, Bruce Psaty, Kurt Lohman, Esteban Burchard, Andre Uitterlinden, Melissa Garcia, Bonnie Joubert, Wendy McArdle, A Musk, Nadia Hansel, Susan Heckbert, Lina Zgaga, Joyce van Meurs, Pau Navarro, Igor Rudan, Yeon-Mok Oh, S. Redline, Deborah Jarvis, Jing Zhao, Taina Rantanen, George O'Connor, Samuli Ripatti
Journal: Nature Genetics (2014)