Canagliflozin reduced kidney failure and CV events at 2.6 years in type 2 diabetes with chronic kidney disease
Authors: Tejas Patel
Journal: Annals of Internal Medicine (2019)

ACP Journal Club20 August 2019Canagliflozin reduced kidney failure and CV events at 2.6 years in type 2 diabetes with chronic kidney diseaseTejas Patel, MD, FACP, FASNTejas Patel, MD, FACP, FASNMontefiore Health System, White Plains Hospital, White Plains, New York, USA (T.P.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJ201908200-015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationPerkovic V, Jardine MJ, Neal B, et al; CREDENCE Trial Investigators. Canagliflozin and renal outcomes in type 2 diabetes and nephropathy. N Engl J Med. 2019;380:2295-306. https://pubmed.ncbi.nlm.nih.gov/30990260Clinical Impact RatingsGIM/FP/GP: Endocrinology: Nephrology: References1 Neal B, Perkovic V, Mahaffey KW, et al; CANVAS Program Collaborative Group. Canagliflozin and cardiovascular and renal events in type 2 diabetes. N Engl J Med. 2017;377:644-57. [PMID: 28605608] Google Scholar2 Zinman B, Wanner C, Lachin JM, et al; EMPA-REG OUTCOME Investigators. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med. 2015;373: 2117-28. [PMID: 26378978] Google Scholar3 Anders HJ, Davis JM, Thurau K. Nephron protection in diabetic kidney disease. N Engl J Med. 2016;375:2096-8. [PMID: 27959742] Google Scholar Author, Article, and Disclosure InformationAffiliations: Montefiore Health System, White Plains Hospital, White Plains, New York, USA (T.P.)This article was published at Annals.org on 6 August 2019. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byReducing Health Care–Associated Infection: Getting Hospitals and Health Systems to ZeroJay Bhatt, DO, MPH and Sue Collier, MSN, RNA Tiered Approach for Preventing Clostridioides difficile InfectionJeffrey M. Rohde, MD, Karen Jones, RN, BSN, MPH, Norma Padron, PhD, MPH, MA, Russell N. Olmsted, MPH, CIC, Vineet Chopra, MD, MSc, and Erik R. Dubberke, MD, MSPHA Tiered Approach for Preventing Catheter-Associated Urinary Tract InfectionJennifer Meddings, MD, MSc, Milisa Manojlovich, PhD, RN, Karen E. Fowler, MPH, Jessica M. Ameling, MPH, Linda Greene, RN, MPS, CIC, Sue Collier, MSN, RN, Jay Bhatt, DO, MPH, MPA, and Sanjay Saint, MD, MPHQualitative Assessment of a State Partner–Facilitated Health Care–Associated Infection Prevention National CollaborativeKaren E. Fowler, MPH, Jane Forman, ScD, Jessica M. Ameling, MPH, Andrew J. Rolle, MPH, Deborah Bohr, MPH, Brittany Schwartz, MPH, Sue Collier, MSN, RN, Vineet Chopra, MD, MSc, and Jennifer Meddings, MD, MScQuantitative Results of a National Intervention to Prevent Central Line–Associated Bloodstream Infection A Pre–Post Observational StudyPayal K. Patel, MD, MPH, M. Todd Greene, PhD, MPH, Karen Jones, RN, MPH, Andrew J. Rolle, MPH, David Ratz, MS, Ashley Snyder, MPH, Sanjay Saint, MD, MPH, and Vineet Chopra, MD, MScQuantitative Results of a National Intervention to Prevent Hospital-Acquired Catheter-Associated Urinary Tract Infection A Pre–Post Observational StudyJennifer Meddings, MD, MSc, Milisa Manojlovich, PhD, RN, Jessica M. Ameling, MPH, Russell N. Olmsted, MPH, CIC, Andrew J. Rolle, MPH, M. Todd Greene, PhD, MPH, David Ratz, MS, Ashley Snyder, MPH, and Sanjay Saint, MD, MPHQuantitative Results of a National Intervention to Prevent Clostridioides difficile Infection A Pre–Post Observational StudyErik R. Dubberke, MD, MSPH, Jeffrey M. Rohde, MD, Sanjay Saint, MD, MPH, Karen Jones, RN, MPH, Ashley Snyder, MPH, Andrew J. Rolle, MPH, and Vineet Chopra, MD, MSc 20 August 2019Volume 171, Issue 4Page: JC15KeywordsACE inhibitorsChronic kidney diseaseEstimated glomerular filtration rateHazard ratioHbA1cHeart failureMyocardial infarctionRenal diseasesRenal failureType 2 diabetes ePublished: 20 August 2019 Issue Published: 20 August 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...