tbuckley/cabot-search huggingface dataset:
Abstract 540: Magnesium Improves Cardiac Diastolic Function by Modulating Mitochondria
Authors: Man Liu, Euy-Myoung Jeong, An Xie, Eui Yong So, Guangbin Shi, Go Eun Jeong, Anyu Zhou, Samuel C Dudley
Journal: Circulation Research (2018)

Rationale: A diet rich in saturated fat has been found to induce diabetes mellitus (DM) accompanied by myocardial mitochondrial dysfunction, insulin resistance, and magnesium (Mg) deficiency. The most prominent characteristic of diabetic cardiomyopathy is cardiac diastolic dysfunction (DD). Mg supplementation improves the heart rate variability and arterial elasticity in chronic heart failure. Recently, we have reported that mitochondrial reactive oxygen species (mitoROS) play a critical role in the progress of DD and diastolic heart failure. Therefore, we hypothesized that Mg supplementation would benefit diastolic function by improving mitochondrial function. Methods and Results: High fat diet (HFD)-induced diabetic mouse hearts showed cardiac DD with increased E/e’ (45±2 in DM mice vs. 32±2 in control mice), increased left ventricular diastolic volume (LVDV, 80±1 μL in DM vs. 61±4 μL in control), and increased incidence of DD (9 of 10 mice in DM vs 1 of 10 mice in control; P&lt;0.05 for all). DM mice also showed decreased plasma Mg concentration (0.80±0.04 mmol/L in DM vs. 0.98±0.03 mmol/L in control, P&lt;0.05). Ventricular cardiomyocytes isolated from DM mice exhibited decreased mitochondrial ATP production (75±11% of control), a 1.7±0.2-fold increase in mitoROS, significantly depolarized mitochondrial membrane potential, and mitochondrial Ca 2+ overload (3.7±1.3-fold; P&lt;0.05 vs. control for all). Dietary Mg administration (50 mg/mL, ≈6-8 g/kg/day) for 6 weeks corrected all these parameters with increased plasma Mg concentration (1.5±0.1 mmol/L), improved cardiac diastolic function (E/e’ 37±1; LVDV 54±5 μL; LVPWT 0.77±0.02 mm; the incidence of DD, 2 of 10 mice; P&lt;0.05 vs. DM for all). Mitochondrial function was improved significantly by Mg with increased ATP production, decreased mitoROS, repolarized mitochondrial membrane potential, and decreased mitochondrial Ca 2+ overload in DM mice. Conclusion: These results indicate that Mg supplementation improved mitochondrial function, reduced oxidative stress, and prevented diastolic dysfunction in DM.
CATHETER ABLATION SCARS AND THE RISK OF CEREBROVASCULAR EVENTS IN PATIENTS WITH ATRIAL FIBRILLATION
Authors: Mobin Kheirkhahan, Matin Goldooz, Alex Baher, David Peritz, Alan Morris, Gagandeep Kaur, Bosten Loveless, Benjamin Hardisty, Ibolya Csecs, Brent Wilson, Mihail Chelu, Nassir Marrouche
Journal: Journal of the American College of Cardiology (2019)
COMPARISON OF TRANSRADIAL VERSUS TRANSFEMORAL ACCESS IN PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION FOR LEFT MAIN CORONARY ARTERY DISEASE: A META-ANALYSIS
Authors: Sunny Goel, Ravi Teja, Elina Zakin, Srilekha Chava, Abhishek Sharma, Bilal Malik, Sergey Ayzenberg, Robert Frankel, Jacob Shani, Umesh Gidwani
Journal: Journal of the American College of Cardiology (2019)
DRUG COATED BALLOON VERSUS PLAIN BALLOON ANGIOPLASTY IN FEMORO-POPLITEAL DISEASE: AN UPDATED META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
Authors: Mahesh Anantha Narayanan, Samit Shah, Jelani Qurat-ul-Ain, Santiago Garcia, Carlos Mena-Hurtado
Journal: Journal of the American College of Cardiology (2019)
Effect of Multinutrient Supplementation and Food-Related Behavioral Activation Therapy on Prevention of Major Depressive Disorder Among Overweight or Obese Adults With Subsyndromal Depressive Symptoms
Authors: Mariska Bot, Ingeborg A. Brouwer, Miquel Roca, Elisabeth Kohls, Brenda W. J. H. Penninx, Ed Watkins, Gerard van Grootheest, Mieke Cabout, Ulrich Hegerl, Margalida Gili, Matthew Owens, Marjolein Visser
Journal: JAMA (2019)

Effects of nutritional interventions on the prevention of major depressive disorder (MDD) in overweight adults are unknown.To examine the effect of 2 nutritional strategies (multinutrient supplementation, food-related behavioral activation therapy) and their combination for prevention of a new MDD episode in overweight adults with subsyndromal depressive symptoms.This multicenter 2 × 2 factorial randomized clinical trial included overweight adults (body mass index, 25-40) with elevated depressive symptoms (Patient Health Questionnaire-9 [PHQ-9] scores ≥5) and no MDD episode in the past 6 months from 4 European countries. A total of 1025 adults were randomized (July 30, 2015-October 12, 2016) and followed up for 1 year (October 13, 2017).Daily multinutrient supplements (1412-mg omega-3 fatty acids, 30-μg selenium, 400-μg folic acid, and 20-μg vitamin D3 plus 100-mg calcium) vs placebo and 21 individual or group therapy sessions vs none (blinded to researchers) for 1 year. Participants were allocated to placebo without therapy (n = 257), placebo with therapy (n = 256), supplements without therapy (n = 256), and supplements with therapy (n = 256).Cumulative 1-year onset of MDD via the Mini International Neuropsychiatric Interview at 3, 6, and 12 months. Logistic regression using effect-coded variables (-1 indicating control, 1 indicating intervention) evaluated intervention effects both individually and in combination (interaction) on MDD onset.Among 1025 participants (mean age, 46.5 years; 772 women [75%]; mean BMI, 31.4), 779 (76%) completed the trial. During the 12-month follow-up, 105 (10%) developed MDD: 25 (9.7%) patients in the placebo without therapy, 26 (10.2%) in the placebo with therapy, 32 (12.5%) in the supplement without therapy, and 22 (8.6%) in the supplement with therapy group. None of the treatment strategies affected MDD onset. The odds ratio (OR) for supplements was 1.06 (95% CI, 0.87-1.29); for therapy, 0.93 (95% CI, 0.76-1.13); and for their combination, 0.93 (95% CI, 0.76-1.14; P for interaction, .48). One person in the supplementation with therapy group, died. Twenty-four patients in each of the placebo groups and 24 patients in the supplementation with therapy group were hospitalized, and 26 patients in the supplementation-only group were hospitalized.Among overweight or obese adults with subsyndromal depressive symptoms, multinutrient supplementation compared with placebo and food-related behavioral activation therapy compared with no therapy did not reduce episodes of major depressive disorder during 1 year. These findings do not support the use of these interventions for prevention of major depressive disorder.ClinicalTrials.gov Identifier: NCT02529423.
DUAL ANTIPLATELET THERAPY (DAPT) CESSATION AND CARDIOVASCULAR RISK IN RELATION TO AGE: ANALYSIS FROM THE PARIS (PATTERNS OF NON-ADHERENCE TO ANTI-PLATELET REGIMENS IN STENTED PATIENTS) REGISTRY
Authors: Lauren Joyce, Usman Baber, Bimmer Claessen, Samantha Sartori, Jaya Chandrasekhar, David Cohen, Timothy Henry, Cono Ariti, George Dangas, Michela Faggioni, C. Michael Gibson, Melissa Aquino, Mitchell Krucoff, Birgit Vogel, David Moliterno, Sabato Sorrentino, Antonio Colombo, Alaide Chieffo, Annapoorna Kini, Paul Guedeney, Bernhard Witzenbichler, Giora Weisz, Philippe Steg, Stuart Pocock, Roxana Mehran
Journal: Journal of the American College of Cardiology (2019)
Stem Cell Transplantation for Pediatric Patients with Non-Anaplastic Peripheral T-Cell Lymphoma on Behalf of the EBMT-Pediatric Diseases Working Party
Authors: Olga Moser, Arnaud Dalissier, Eric Beohou, Wilhelm Woessmann, Birgit Burkhardt, Karin Mellgren, Peter Bader, Andre Manfred Willasch, Udo Kontny
Journal: Blood (2018)
NON-RECOMMENDED DOSING OF DIRECT ORAL ANTICOAGULANTS IN THE TREATMENT OF ACUTE PULMONARY EMBOLISM IS RELATED TO AN INCREASED RATE OF ADVERSE EVENTS
Authors: Romain Chopard, Guillaume Serzian, Sebastien Humbert, Nicolas Falvo, Mathilde Morel, Benjamin Bonnet, Gabriel Napporn, Elsa Kalbacher, Laurent Obert, Bruno Degano, Gilles Capellier, Yves Cottin, Francois Schiele, Nicolas Meneveau
Journal: Journal of the American College of Cardiology (2019)
Abstract PD8-05: POSNOC - Positive sentinel node: Adjuvant therapy alone versus adjuvant therapy plus clearance or axillary radiotherapy
Authors: A Goyal, B Mann, AM Thompson
Journal: Cancer Research (2019)

Abstract Background: Role of additional axillary treatment (AxT) (axillary lymph node dissection (ALND) or axillary radiotherapy (ART)) in women with ≤2 macrometastases and undergoing systemic therapy remains unclear. Z11 included both micro and macrometastases (around 40% micrometastases) and showed that ALND may be omitted in women with ≤2 positive nodes undergoing breast conserving surgery (BCS) and receiving whole breast RT. Paradoxically, NCIC MA20, demonstrated improved DFS following the addition of regional RT. 51.8% (949/1832) had 1 or 2 positive nodes. 98.9% (1812/1832) had T1/T2 tumours. A post-Z11 survey shows that most US radiation oncologists treat the undissected axilla in women with macrometastases with ART rather than omitting AxT. Therefore, a confirmatory study is needed to clarify the role of additional AxT in women with ≤2 macrometastases undergoing BCS and other subgroups that were not included in Z11 e.g. mastectomy, microscopic extranodal invasion and sentinel node biopsy (SNB) before neoadjuvant chemotherapy. Methods: Primary objective is to assess whether for women with ≤2 macrometastases at SNB, systemic therapy alone is non-inferior to systemic therapy plus AxT in terms of axillary recurrence at 5 years. Secondary objectives are arm morbidity assessed by LBCQ and QuickDASH questionnaires; QoL assessed by FACT-B+4 questionnaire; anxiety assessed by STAI; loco-regional recurrence; distant metastasis; time to axillary recurrence; axillary recurrence-free survival; DFS; OS; contralateral breast cancer; non-breast malignancy; and economic evaluation. Eligibility criteria include: ≥18 y, uni or multifocal invasive cancer, T1/T2, 1 or 2 macrometastases, with or without extranodal invasion. Target sample size is 1900 with a projected drop-out and non-compliance with treatment allocation rate of 10%. Primary analysis will be per protocol. The following pre-specified subgroup analyses shall be performed: number of macrometastases (1, 2), age (&amp;lt;50, ≥50), breast surgery (mastectomy, BCS), ER (positive, negative), tumour grade (1 or 2, 3), SN assessment technique (OSNA, non-OSNA), extranodal invasion (present, absent). POSNOC opened to recruitment in July 2014. To date 1100 women have been recruited at 82 sites in the UK and 18 sites in Australia and New Zealand. Clinicaltrials.gov NCT02401685. Citation Format: Goyal A, Mann B, Thompson AM. POSNOC - Positive sentinel node: Adjuvant therapy alone versus adjuvant therapy plus clearance or axillary radiotherapy [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr PD8-05.
A RETROSPECTIVE COMPARISON OF TRICUSPID VALVE SURGERY TO TRICUSPID VALVE VEGETATION DEBULKING WITH ANGIOVAC FOR ISOLATED TRICUSPID VALVE ENDOCARDITIS
Authors: Bennet J. George, Patricia Santos, Katherine Donaldson, Thaer Musa, John Kotter, Susan Smyth, Andrew Leventhal, John Gurley
Journal: Journal of the American College of Cardiology (2019)
OUTCOMES OF HYBRID TECHNIQUE FOR AORTIC ARCH DISEASES IN 379 CONSECUTIVE PATIENTS OVER A 12-YEAR PERIOD
Authors: Huanyu Ding, Yi Zhu, Enmin Xie, Songyuan Luo, Ling Xue, Wenhui Huang, Yuan Liu, Ruixin Fan, Jianfang Luo
Journal: Journal of the American College of Cardiology (2019)
Abstract 265: TGF Beta Signaling and Fibrosis in cMyBP-C-dependent Cardiac Disease
Authors: Qinghang Meng, Bidur Bhandary, Hanna Osinska, Jeanne James, Kritton Shay-Winkler, James Gulick, James McNamara, Md. Shenuarin Bhuiyan, Sakthivel Sadayappan, Jeffrey Robbins
Journal: Circulation Research (2018)

Background: Mutations in cardiac myosin binding protein C ( MYBPC3 ) account for more than one third of identified hypertrophic cardiomyopathy (HCM). Data from both human patients and mouse models suggest that cardiac fibrosis preceeds hypertrophy and cardiac dysfunction, implying that fibrosis related signaling may be one of the initial signs of developing cardiac disease. We wished to determine if cardiomyocyte-autonomous TGFβ signaling is sufficient to initiate pathogenic fibrosis in the heart in the context of a cMyBP-C-induced disease. Methods and Results: Neonatal rat ventricular cardiomyocytes (NRVMs) expressing either wild-type or Mybpc3 mutations were mediated by adenovirus for 48 hours. Both cells and culture medium (conditional medium) were harvested. The fibrotic effects of the conditional medium on neonatal rat ventricular fibroblasts (NRVFs) were determined using “fibrotic” gene promoters driving luciferase (luc) expression ( αSMA-luc , postn-luc and col1a1-luc ). TGFβ levels in the conditional medium were determined using ELISA assays. Expression of cMybpc3 mutations activated TGFβ promoter activity ( Tgfb1-luc , Tgfb2-luc and Tgfb3-luc ) in a TGFβ receptor(s) (TβRs) dependent manner. Upregulation of TGFβ was also confirmed in transgenic mice expressing a fragment of cMyBP-C (cMyBP-C 40kDa ) whose expression results in significant fibrosis and cardiac disease. To establish causality, we genetically ablated TGFβ receptors ( Tgfbr1 and Tgfbr2 ) in the cardiomyocytes of the cMybpc3 40kDa mice. TGFβ receptors ablation blocked the induction of TGFβ expression, alleviating cardiac fibrosis and decreasing cardiac hypertrophy. Cardiac function was significantly improved and survival of the cMyBP-C 40kDa mice was increased. Conclusions: Cardiomyocytes are a critical source of TGFβ in cMyBP-C 40kDa hearts during the initial stages of pathogenesis. Thus, TβRs ablation at the early stage completely prevent the progression of the pathological process in vivo .
IN-HOSPITAL OUTCOMES AFTER MITRACLIP IMPLANTATION IN HFPEF VERSUS HFREF NATIONWIDE INPATIENT SAMPLE
Authors: Ujjwal Rastogi, Dhrubajyoti Bandyopadhyay, Vivek Modi, Ankur Sethi, Priyanka Rastogi, Sagar Mallikethireddy, Johanna Contreras, Jagat Narula, Samin Sharma
Journal: Journal of the American College of Cardiology (2019)
NON-PULMONARY VEIN TRIGGER ABLATION IMPROVES THE SINGLE-PROCEDURE SUCCESS RATE OF CATHETER ABLATION IN PERSISTENT ATRIAL FIBRILLATION: RESULTS FROM A LARGE PROSPECTIVE MULTICENTRE EXPERIENCE
Authors: Domenico Giovanni Della Rocca, Sanghamitra Mohanty, Chintan Trivedi, Qiong Chen, Omer Gedikli, Amin Al-Ahmad, John Burkhardt, Gerald Gallinghouse, Javier Sanchez, Alfredo Chauca Tapia, Rodney Horton, Sharan Sharma, Dhanunjaya Lakkireddy, Luigi Di Biase, Andrea Natale
Journal: Journal of the American College of Cardiology (2019)
Additional Gene Mutations Refine the 2017 European Leukemianet (ELN) Classification of Adult Patients (Pts) with De Novo Acute Myeloid Leukemia (AML) Aged &lt;60 Years: An Analysis of Alliance for Clinical Trials in Oncology (Alliance) Studies
Authors: Ann-Kathrin Eisfeld, Jessica Kohlschmidt, Krzysztof Mrózek, Alice S. Mims, Christopher J. Walker, Deedra Nicolet, James S. Blachly, Andrew J. Carroll, Jonathan E. Kolitz, Bayard L. Powell, Richard M. Stone, Albert de la Chapelle, John C. Byrd, Clara D. Bloomfield
Journal: Blood (2018)
VALVULAR FOLLOW-UP AFTER CATHETER ABLATION OF PAPILLARY MUSCLES AND AORTIC CUSPS IN THE TREATMENT OF VENTRICULAR ARRHYTHMIAS
Authors: Justin A. Edward, William Sauer, Matthew Zipse, Wendy S. Tzou, Christine Tompkins, Paul Varosy, Amneet Sandhu, Michael Rosenberg, Ryan Borne, Ryan Aleong, Duy Nguyen
Journal: Journal of the American College of Cardiology (2019)
THE EFFECT OF A NURSE-DRIVEN PROGRAM UTILIZING IMPLANTABLE PULMONARY ARTERY PRESSURE MONITORING TO REDUCE HOSPITALIZATIONS IN LOW-SOCIOECONOMIC URBAN PATIENTS WITH HEART FAILURE
Authors: Charina F. Alcain, Rahmana Aziz, Rhys Chua, Corey Tabit
Journal: Journal of the American College of Cardiology (2019)
INCREASED RESIDUAL CARDIOVASCULAR RISK IN US VETERANS AND MONERATELY-ELEVATED BASELINE TRIGLYCERIDES AND WELL-CONTROLLED LDL-C LEVELS ON STATINS
Authors: Sarah Leatherman, Ryan Ferguson, Isabelle Weir, Cynthia Hau, Craig Granowitz, Kelly Harrington, Sephy Philip, Peter Toth, Deepak L. Bhatt, William Boden
Journal: Journal of the American College of Cardiology (2019)
CLINICAL OUTCOME ASSESSMENT SCORES FOR PATIENTS WITH TRANSTHYRETIN AMYLOIDOSIS WITH OR WITHOUT ACCOMPANYING CARDIOMYOPATHY OR CONGESTIVE HEART FAILURE
Authors: Asia Sikora Kessler, Aaron Yarlas, Andrew Lovley, Kristen L. McCausland, Spencer Guthrie, Michael Pollock, Michelle K. White
Journal: Journal of the American College of Cardiology (2019)
Retrodifferentiation of Human Tumor Hepatocytes to Stem Cells Leads to Metabolic Reprogramming and Chemoresistance
Authors: Karim Fekir, Hélène Dubois-Pot-Schneider, Romain Désert, Yoann Daniel, Denise Glaise, Claudine Rauch, Fabrice Morel, Bernard Fromenty, Orlando Musso, Florian Cabillic, Anne Corlu
Journal: Cancer Research (2019)

Abstract Human hepatocellular carcinoma (HCC) heterogeneity promotes recurrence and therapeutic resistance. We recently demonstrated that inflammation favors hepatocyte retrodifferentiation into progenitor cells. Here, we identify the molecular effectors that induce metabolic reprogramming, chemoresistance, and invasiveness of retrodifferentiated HCC stem cells. Spheroid cultures of human HepaRG progenitors (HepaRG-Spheres), HBG-BC2, HepG2, and HuH7 cells and isolation of side population (SP) from HepaRG cells (HepaRG-SP) were analyzed by transcriptomics, signaling pathway analysis, and evaluation of chemotherapies. Gene expression profiling of HepaRG-SP and HepaRG-Spheres revealed enriched signatures related to cancer stem cells, metastasis, and recurrence and showed that HepaRG progenitors could retrodifferentiate into an immature state. The transcriptome from these stem cells matched that of proliferative bad outcome HCCs in a cohort of 457 patients. These HCC stem cells expressed high levels of cytokines triggering retrodifferentiation and displayed high migration and invasion potential. They also showed changes in mitochondrial activity with reduced membrane potential, low ATP production, and high lactate production. These changes were, in part, related to angiopoietin-like 4 (ANGPTL4)–induced upregulation of pyruvate dehydrogenase kinase 4 (PDK4), an inhibitor of mitochondrial pyruvate dehydrogenase. Upregulation of ANGPTL4 and PDK4 paralleled that of stem cells markers in human HCC specimens. Moreover, the PDK4 inhibitor dichloroacetate reversed chemoresistance to sorafenib or cisplatin in HCC stem cells derived from four HCC cell lines. In conclusion, retrodifferentiated cancer cells develop enhanced invasion and therapeutic resistance through ANGPTL4 and PDK4. Therefore, restoration of mitochondrial activity in combination with chemotherapy represents an attractive therapeutic approach in HCC. Significance: Restoring mitochondrial function in human hepatocellular carcinomas overcomes cancer resistance.
Biologic Disease-Modifying Antirheumatic Drugs and Risk of Multiple Myeloma
Authors: Gregory Sampang Calip, Karen Sweiss, Sruthi Adimadhyam, Alemseged Ayele Asfaw, Jifang Zhou, Zhaoju Wu, Todd Lee, Brian C.-H. Chiu, Pritesh Patel
Journal: Blood (2018)
Abstract 104: AAV-Exosomes: A Novel Platform for Myocardial Gene Delivery for Cardioprotection
Authors: Marta Adamiak, Yaxuan Liang, Prabhu Mathiyalagan, Neha Agarwal, Erik Kohlbrenner, Divya Jha, Elena Chepurko, Dongtak Jeong, Delaine Ceholski, Nicole Dubois, Roger Hajjar, Susmita Sahoo
Journal: Circulation Research (2018)

Introduction: Adeno-associated viruses (AAVs) are viral vectors of choice for delivering genes for long-term expression due to their safety in clinics. However, pre-existing immunity to AAVs from naturally present neutralizing antibodies (NAbs, present in between 60% and 90% of population) poses a significant challenge for AAV-mediated gene delivery. NAbs prevent AAVs from infecting target cells, greatly reducing transduction efficiency and, therefore, the clinical efficacy. Thus, it is essential to develop novel AAV-based vectors that circumvent the effect of NAbs. Objectives: We aimed to investigate the ability of exosome-encapsulated AAVs (AAVExo) to evade NAbs and serve as a highly efficient gene transfer tool for cardiovascular therapeutics. Methods and Results: We developed a multi-step purification strategy using iodixanol density gradient to isolate AAVExo with minimal contamination from free AAVs (AAV1, 6 or 9). Biochemical assays, flow cytometry, IVIS Spectrum in vivo optical imaging and echocardiography were used to detect AAV-mediated gene delivery and evaluate cardiac function. AAV6Exo-mCherry and AAV9Exo-FLuc were resistant to NAbs and significantly improved expression of mCherry and firefly luciferase (FLuc) both in mouse and human (iPSC-derived) cardiomyocytes in vitro , and in murine hearts in vivo (in nude mice preinjected with NAbs), compared to free AAVs. To test the therapeutic efficacy of AAVExo-mediated gene delivery in the presence of NAbs, we injected AAV9-SERCA2a or AAV9Exo-SERCA2a into post-MI hearts of nude mice preinjected with IVIg (human intravenous immunoglobulin) preparation. Hearts treated with AAV9Exo-SERCA2a had significantly improved cardiac function compared to those treated with free AAV9-SERCA2a (%EF 62.6 ± 9.8 vs. 28.4 ± 5.3, respectively; 2 weeks after surgery). Conclusion: Delivery of AAVs protected by carrier exosomes is a promising approach to circumvent the issue of NAbs in AAV-based gene therapy, which can be used in the entire population of patients and may result in higher gene delivery efficacy.
FACTORS ASSOCIATED WITH CHANGES IN MORTALITY OVER TIME AND HOME DEATHS IN PHASE 1 OF THE NATIONAL PEDIATRIC CARDIOLOGY QUALITY IMPROVEMENT COLLABORATIVE
Authors: Dongngan T. Truong, Zhining Ou, David K. Bailey, Phillip Burch, Eric R. Griffiths, L. LuAnn Minich
Journal: Journal of the American College of Cardiology (2019)
Graft-Versus-Host Disease Prophylaxis with Posttransplantation Cyclophosphamide and Ruxolitinib in Patients with Myelofibrosis
Authors: Elena V Morozova, Ivan S Moiseev, Maria V Barabanshikova, Elena I Darskaya, Sergey N. Bondarenko, Ludmila S Zubarovskaya, Vadim Baykov, Alexandr L Alyanski, Ildar M Barkhatov, Axel R. Zander, Boris V Afanasyev
Journal: Blood (2017)
ENDOTHELIAL SHEAR STRESS DERIVED FROM SERIAL NONINVASIVE CORONARY CTA: EFFECT OF WALL ELASTICITY IN A FEASIBILITY STUDY
Authors: Parastou Eslami, Alison Marsden, Justin Tran, Janet Lo, Romina Sotoodeh, Ahmet Coskun, Peter Stone, Udo Hoffmann, Michael Lu
Journal: Journal of the American College of Cardiology (2019)
FRACTIONAL FLOW RESERVE GUIDED MULTI-VESSEL PERCUTANEOUS CORONARY INTERVENTION VERSUS ANGIOGRAPHY-GUIDED CULPRIT LESION ONLY PERCUTANEOUS CORONARY INTERVENTION FOR ACUTE CORONARY SYNDROMES: A META-ANALYSIS
Authors: Varun Kohli, Furqan Habib Khattak, Timir Paul
Journal: Journal of the American College of Cardiology (2019)
The True Cost of Measles Outbreaks During the Postelimination Era
Authors: Maria E. Sundaram, L. Beryl Guterman, Saad B. Omer
Journal: JAMA (2019)

This Viewpoint reviews measles outbreaks in the United States since the year 2000 attributable to vaccine hesitancy, refusal, and exemption, and specifies the costs to individuals, society, and health systems as a result.