tbuckley/cabot-search huggingface dataset:
Outcome of Relapse After Allogeneic Transplantation for Childhood Acute Lymphoblastic Leukemia In Complete Remission. A Study of the Pediatric Diseases and Acute Leukemia Working Parties of the EBMT Group
Authors: Adriana Balduzzi, Myriam Labopin, Vanderson Rocha, Nabila Elarouci, Giorgio Dini, Peter Bader, Mohamad Mohty, Christina Peters
Journal: Blood (2010)
Refined Hepatic Grading System Improves Risk Stratification of Long-Term Outcomes in the Patients Developing Chronic Gvhd
Authors: Saud Alhayli, Elizabeth Shin, Wilson Lam, Uday Deotare, Fotios V. Michelis, Santhosh Thyagu, Auro Viswabandya, Jeffrey H. Lipton, Hans A. Messner, Dennis Dong Hwan Kim
Journal: Blood (2016)
Sickle Cell Disease Proteinuria Is Not Associated With Systolic Blood Pressure, CSSCD-Defined Hypertension, or Family History Of Hypertension In An International Cohort Of SCD Patients
Authors: Andrew Campbell, Biree Andemariam, Fredericka Sey, Connie M. Piccone, Baba PD Inusa, Silverio Perrotta, Imma Tartaglione, William Zempsky, Crawford John Strunk, Rebekah Urbonya, Laura Sainati, Adetola A. Kassim, Charles Antwi-Boasiako, Deepa Manwani, Raffaella Colombatti
Journal: Blood (2013)
Bhardwaj A, Sethi G, Vadhan-Raj S, et al. Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-κB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells. Blood. 2007;109(6):2293-2302.
Journal: Blood (2013)
IHC Analysis and Prognostic Factors in Post Transplant Lymphoproliferative Disorders after Solid Organ Transplantation: A Single Center Experience
Authors: Zohra Nooruddin, William Robinson, Daniel Pollyea, Jonathan A Gutman, Clayton Smith, Zenggang Pan, Craig T Jordan, Rachel Rabinovitch, Jeffrey Schowinsky, Xian Lu, Douglas Ney, Manali Kamdar
Journal: Blood (2015)
Novel BAFF-Receptor Antibody to Natively Folded and Glycosylated Recombinant Protein Eliminates Drug Resistant B Cell Malignancies In Vivo
Authors: Hong Qin, Guowei Wei, Ippei Sakamaki, Zhenyuan Dong, Diane Lynne Smith, Feng Wen, Han Sun, Wesley A Cheng, Larry W Kwak
Journal: Blood (2016)
In Adult Acute Lymphoblastic Leukemia (ALL) Different Minimal Residual Disease (MRD) Levels Predict Clinical Outcome in All Patients and Response to Allogeneic/Autologous Transplantation in MRD-Positive Patients.
Authors: Renato Bassan, Orietta Spinelli, Elena Oldani, Manuela Tosi, Barbara Peruta, Erika Borlenghi, Enrico Maria Pogliani, Eros Di Bona, Vincenzo Cassibba, Anna Maria Scattolin, Claudio Romani, Fabio Ciceri, Agostino Cortelezzi, Giacomo Gianfaldoni, Daniele Mattei, Ernesta Audisio, Tamara Intermesoli, Alessandro Rambaldi
Journal: Blood (2012)
Conventional and Molecular Cytogenetic Responses in Patients with Myelodysplastic Syndrome (MDS) with Deletion 5q Treated with Lenalidomide.
Authors: Rita Coutinho, Dolors Costa, Ana Carrió, Ana Vidal, Mohammed Belkaid, Elias Campo, Emili Montserrat, Benet Nomdedeu
Journal: Blood (2009)
Plasminogen Is a Critical Host Pathogenicity Factor for Group A Streptococcal Infection.
Authors: Hongmin Sun, Ulrika Ringdahl, Jonathon W. Homeister, William P. Fay, N. Cary Engleberg, Angela Y. Yang, Laura S. Rozek, Xixi Wang, Ulf Sjobring, David Ginsburg
Journal: Blood (2004)
Analysis of Apoptosis Regulatory Genes Expression in the Bone Marrow of Adult De Novo Myelodysplastic Syndromes (MDS).
Authors: C. Economopoulou, Vassiliki Pappa, F. Kontsioti, V. Kapsimali, C. Papasteriadi, P. Tsirigotis, S. Papageorgiou, V. Giannopoulou, I. Kaitsa, E. Papageorgiou, J. Dervenoulas, T. Economopoulos
Journal: Blood (2006)
Bortezomib-Based Regimens As Consolidation Therapy after Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma: A Single Center Experience from Oran (Algeria)
Authors: Souad Talhi, Soufi Osmani, Mohamed Brahimi, Kamila Amani, Hafida Ouldjeriouat, Samira Bouchama, Leila Charef, Mohamed Amine Mazari, Badra Entasoltan, Nabil Yafour, Amina Krim, Rachid Amar Bouhass, Abdessamed Arabi, Mohamed Amine Bekadja
Journal: Blood (2016)
The Poor Outcome of Multiple Myeloma (MM) Patients Carrying At Diagnosis Deleted TP53 and or Amplified MDM4 Might Be Related to the Deregulation of Genes Involved in Cell Cycle Control and DNA Damage Repair
Authors: Carolina Terragna, Marina Martello, Nicoletta Testoni, Emanuele Angelucci, Annamaria Brioli, Stelvio Ballanti, Laura Dessanti, Valerio De Stefano, Gioacchino Catania, Jacopo Peccatori, Luca Castagna, Salvatore Palmieri, Giulia Perrone, Vincenzo Callea, Catello Califano, Anna Baraldi, Enrica Borsi, Luciana Pasini, Mariella Grasso, Pellegrino Musto, Patrizia Tosi, Giovanni Martinelli, Michele Cavo
Journal: Blood (2012)
Favorable Outcome of Reduced-Intensity Stem Cell Transplantation for Adult T-Cell Leukemia
Authors: Fumie Iwai, Hitomi Kaneko, Goichi Tatsumi, Tadahiko Matsumoto, Shinya Inada, Yuki Sueki, Nao Toyooka, Sumie Fujii, Chisiho Nakamura, Mitsumasa Watanabe, Hirokazu Hirata, Yasuo Miura, Mitsuru Tsudo
Journal: Blood (2011)
Favorable Immune Reconstitution Profile after Allogeneic Hematopoietic Stem Cell Transplantation with Post-Transplant Cyclophosphamide
Authors: Omer Hassan Jamy, Ayman Saad, Rachael Orlandella, Samantha B Langford, Ravi K. Paluri, Racquel Innis-Shelton, Shin Mineishi, Lawrence S. Lamb
Journal: Blood (2016)
Comparative study on safety after primary and secondary treatment in EGFR positive NSCLC administered Osimertinib
Authors: Kengo Umehara, Keisuke Gto, Yuki Okayama, Shiori Noomote, Takayuki Toda, Yasuka Okazaki, Azusa Wakamoto, Tae Hatsuyama, Osamu Honjo, Hideki Sato
Journal: Annals of Oncology (2019)
Multi-Center Clinical Trial of CAR T Cells in Pediatric/Young Adult Patients with Relapsed B-Cell ALL
Authors: Kevin J. Curran, Isabelle Riviere, Lewis B. Silverman, Rachel Kobos, Neerav Shukla, Peter G Steinherz, Farid Boulad, Susan Prockop, Andromachi Scaradavou, Steven P. Margossian, Xiuyan Wang, Yongzeng Wang, Victoria Szenes, Colleen H Dansereau, Brenda MacKinnon, Craig S. Sauter, Jae H. Park, Nancy A. Kernan, Richard J O'Reilly, Michel Sadelain, Renier J. Brentjens
Journal: Blood (2015)
TCR γδ Large Granular Lymphocyte Leukemia (LGLL) Displays Features between CD8+ and CD4+ TCR αβ LGLL
Authors: Antonella Teramo, Elena Ciabatti, Giulia Tarrini, Iacopo Petrini, Gregorio Barilà, Giulia Calabretto, Cristina Vicenzetto, Matteo Leoncin, Anna Cabrelle, Francesco Piazza, Sara Galimberti, Roberto Grossi, Nadia Pisanti, Gianpietro Semenzato, Renato Zambello
Journal: Blood (2017)
Markers of Thromboembolic Risk Were Insignificantly Affected By Either Intraosseous or Intravenous Idarucizumab in a Dabigatran-Anticoagulated Porcine Polytrauma Model
Authors: Markus Honickel, Akman Necib, Hugo ten Cate, Rolf Rossaint, Oliver Grottke
Journal: Blood (2016)
A Monoclonal Antibody to High Molecular Weight Kininogen Reduces Inflammation in the HLA-B27 Transgenic Rat Model of Inflammatory Bowel Disease and Arthritis.
Authors: Robin A. Pixley, Irma M. Sainz, James C. Keith, Irma Isordia-Salas, Yelena Leatherby, Leo M. Albert, Robert W. Colman
Journal: Blood (2004)
Cyclosporine Modulation of Multidrug Resistance in Combination with Pravastatin, Mitoxantrone, and Etoposide for Adult Patients with Relapsed/Refractory Acute Myeloid Leukemia (AML): A Phase 1/2 Study
Authors: Tara L Chen, Elihu H. Estey, Megan Othus, Kelda M. Gardner, Lauren Markle, Roland B. Walter
Journal: Blood (2012)
A Theoretical Framework for Clinical Implementation of Social Determinants of Health
Authors: Gmerice Hammond, Karen E. Joynt Maddox
Journal: JAMA Cardiology (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
The Bidirectional Relationship Between Cytomegalovirus Replication and Graft-Versus-Host Disease - a Retrospective Single Center Study.
Authors: Nathan Cantoni, Hans H Hirsch, Nina Khanna, Dominik Heim, Joerg Halter, Dimitrios Tsakiris, Christoph Bucher, Alicia Rovò, Caroline Arber, Andreas S Buser, Andre Tichelli, Alois Gratwohl, Martin Stern
Journal: Blood (2009)
Base Excision Repair Gene OGG1 Affects the Relapse Risk of Acute Myeloid Leukemia
Authors: Nanami Gotoh, Takayuki Saitoh, Noriyuki Takahashi, Rumi Ino, Yuya Kitamura, Kazuki Honma, Tomomi Nagashima, Tetsuhiro Kasamatsu, Takumi Hoshino, Toru Sakura, Makiko Takizawa, Akihiko Yokohama, Hiroaki Shimizu, Hiroshi Handa, Norifumi Tsukamoto, Hirokazu Murakami
Journal: Blood (2016)
Sickle-Cell Disease and Malaria: Evaluation of Seasonal Intermittent Preventive Treatment with Sulfadoxine-Pyrimethamine in Senegalese patients—a Randomized Placebo-Controlled Trial
Authors: Saliou Diop, Moussa Seck, Youssou Bamar Gueye, Fabienne Soudre, Awa Oumar Touré Fall, Abibatou Sall, Doudou Thiam
Journal: Blood (2010)
Endoscopic management of Lynch syndrome and of familial risk of colorectal cancer: European Society of Gastrointestinal Endoscopy (ESGE) Guideline
Authors: Monique E. van Leerdam, Victorine H. Roos, Jeanin E. van Hooft, Francesc Balaguer, Evelien Dekker, Michal F. Kaminski, Andrew Latchford, Helmut Neumann, Luigi Ricciardiello, Maria Rupińska, Jean-Christophe Saurin, Pieter J. Tanis, Anja Wagner, Rodrigo Jover, Maria Pellisé
Journal: Endoscopy (2019)

ESGE recommends that individuals with Lynch syndrome should be followed in dedicated units that practice monitoring of compliance and endoscopic performance measures.Strong recommendation, low quality evidence, level of agreement 100 %.ESGE recommends starting colonoscopy surveillance at the age of 25 years for MLH1 and MSH2 mutation carriers and at the age of 35 years for MSH6 and PMS2 mutation carriers.Strong recommendation, moderate quality evidence, level of agreement 100 %. ESGE recommends the routine use of high-definition endoscopy systems in individuals with Lynch syndrome. Strong recommendation, high quality evidence, level of agreement 100 %. ESGE suggests the use of chromoendoscopy may be of benefit in individuals with Lynch syndrome undergoing colonoscopy; however routine use must be balanced against costs, training, and practical considerations.Weak recommendation, moderate quality evidence, level of agreement 89 %.ESGE recommends definition of familial risk of colorectal cancer as the presence of at least two first-degree relatives with colorectal cancer or at least one first-degree relative with colorectal cancer before the age of 50 years.Strong recommendation, moderate quality evidence, level of agreement 92 %.ESGE recommends colonoscopy surveillance in first-degree relatives of colorectal cancer patients in families that fulfill the definition of familial risk of colorectal cancer.Strong recommendation, moderate quality evidence, level of agreement 100 %.
Incidence, risk factors and clinical features of febrile neutropenia in malignant lymphoma patients in our institution
Authors: Ai Mogi, Yuta Nakashima, Naoko Kunami, Maki Goto, Atsushi Togawa, Hidenori Sasaki, Toshihiro Tanaka, Toru Takata, Kazuo Tamura, Yasushi Takamatsu
Journal: Annals of Oncology (2019)
Influence Of Killer Immunoglobulin-Like Receptor (KIR) and HLA Genotypes On Outcomes After Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem Cell Transplantation For Patients With AML and MDS: A Report From The Center For International Blood and Marrow Transplant Research Immunobiology Working Committee
Authors: Ronald M. Sobecks, Meighan M. Gallagher, Medhat Askar, Michael D. Haagenson, Tao Wang, Stephen Spellman, Stephanie J. Lee, Marcelo A. Fernandez Viña, Carlheinz R. Muller, Michael R. Verneris, Ann E. Woolfrey, Peter J. Shaw, Daniel J. Weisdorf, Sarah Cooley, Jeffrey S. Miller, Katharine C. Hsu
Journal: Blood (2013)
Induced Hematopoietic Differentiation Of Common Marmoset Embryonic Stem Cells By LYL1 Can Give Rise To Hematopoietic Stem Cells Having The Enhanced Bone Marrow Reconstitution Capability
Authors: Hirotaka Kawano, Tomotoshi Marumoto, Takafumi Hiramoto, Michiyo Okada, Tomoko Inoue, Takenobu Nii, Jiyuan Liao, Saori Yamaguchi, Hiroyuki Inoue, Erika Sasaki, Yoshie Miura, Kenzaburo Tani
Journal: Blood (2013)
NGS-Assisted DNA-Based Digital qPCR Facilitates Stratification Of CML Patients In Long-Term Molecular Remission Based On The Presence Of Detectable BCR-ABL1 DNA
Authors: Mary Alikian, Peter Ellery, Matrin Forbes, Gareth Gerrard, Tim Aitman, Dalia Kasperaviciute, Dragana Milojkovic, David Marin, John M Goldman, Jane F Apperley, Letizia Foroni, Alistair Reid
Journal: Blood (2013)
Analysis of Efficacy By Age for Patients Aged 60-75 with Untreated Secondary Acute Myeloid Leukemia (AML) Treated with CPX-351 Liposome Injection Versus Conventional Cytarabine and Daunorubicin in a Phase III Trial
Authors: Bruno C. Medeiros, Jeffrey E. Lancet, Jorge E. Cortes, Laura F Newell, Tara L. Lin, Ellen K. Ritchie, Robert K. Stuart, Stephen A. Strickland, Donna Hogge, Scott R. Solomon, Richard M. Stone, Dale L. Bixby, Jonathan E. Kolitz, Gary J. Schiller, Matthew J. Wieduwilt, Daniel H. Ryan, Antje Hoering, Michael T. Chiarella, Arthur C. Louie, Geoffrey L. Uy
Journal: Blood (2016)
Dynamic Regulation of the Level of Hypoxia In the Bone Marrow Regulates Cell Dissemination In Multiple Myeloma
Authors: Abdel Kareem A. Azab, Phong Quang, Feda Azab, Brian Thompson, Patricia Maiso, Aldo M. Roccaro, Antonio Sacco, Hai T Ngo, Kenneth C. Anderson, Andrew L. Kung, Charles Lin, Irene M. Ghobrial
Journal: Blood (2010)
Chromosome 16q Located Genes CDH1, CDH13 and ADAMTS18 Are Correlated and Frequently Methylated But Not Associated With DNMTs levels In Human Lymphoma
Authors: Lobna A Alkebsi, Hiroshi Handa, Kenichi Tahara, Hiroaki Shimizu, Takuma Ishizaki, Kunio Yanagisawa, Makiko Takizawa, Akihiko Yokohama, Hiromi Koiso, Takeki Mitsui, Takayuki Saitoh, Norifumi Tsukamoto, Yoshihisa Nojima, Hirokazu Murakami
Journal: Blood (2013)
Utilising functional imaging to predict survival in paediatric brain tumours.
Authors: James Grist, Stephanie Withey, Lesley MacPherson, Adam Oates, Mr Stephen Powell, Jan Novak, Laurence Abernethy, Barry Pizer, Richard Grundy, Simon Bailey, Dipayan Mitra, Theodoros Arvantis, Dorothee Auer, Shivaram Avula, Andrew Peet
Journal: Neuro-Oncology (2019)

Abstract Introduction Brain tumours are a common cause of death in the paediatric population. We have previously shown that MR imaging and spectroscopy can be used to non-invasively differentiate between tumour types. Here, we demonstrate that functional imaging can be highly predictive of survival and grade in a paediatric cohort. Methods Perfusion (PWI) and diffusion weighted imaging (DWI) were performed in a multi-site (Birmingham Children’s Hospital, Royal Victoria Infirmary, Alder Hey, Nottingham) cohort ([grade, 5-year survival alive:dead number] = [I,15:1],[II, 5:1],[III,2:3],[IV,8:11]). ROIs were drawn on T2 imaging and functional imaging features (mean, standard deviation, skewness, and kurtosis) were derived. Supervised machine learning was used to predict 5-year survival and tumour grade from features. ANOVA and post-hoc tests were used to assess differences in features between grade and 5-year survival status. Results 5-year survival was predicted with 89%, 85%, and 87% accuracy with all imaging, perfusion, or diffusion features, respectively. A significant difference in perfusion was found between surviving and diseased participants (1.71 ± 0.82 vs 2.62 ± 1 mL/100g/min, respectively, p &lt; 0.05). A significant difference in ADC (mm2 s-1) between tumour grades was found (1 vs 4 (1533 ± 458 vs 857 ± 239), 4 vs 3 (857 ± 239 vs 1197 ± 137), 4 vs 2 (857 ± 239 vs 1440 ± 557), corrected p &lt; 0.05). Conclusion We have shown that perfusion and diffusion imaging features can be used to non-invasively assess tumour grade and estimate 5-year survival status in a cohort of paediatric brain tumours.
Evaluation of Oral Azacitidine Using Extended Treatment Schedules: A Phase I Study
Authors: Guillermo Garcia-Manero, Steven D. Gore, Christopher R. Cogle, Elias J. Jabbour, M. Renee Ward, Kyle J. MacBeth, Eric Laille, Heidi Giordano, Hagop M. Kantarjian, Barry S. Skikne
Journal: Blood (2010)
High CD49d Protein Expression Predicts Short Overall Survival and Early Progression in Chronic Lymphocytic Leukemia Patients.
Authors: Valter Gattei, Pietro Bulian, Maria Ilaria Del-Principe, Antonella Zucchetto, Luca Maurillo, Francesco Buccisano, Riccardo Bomben, Michele Dal-Bo, Fabrizio Luciano, Francesca M. Rossi, Massimo Degan, Sergio Amadori, Giovanni Del-Poeta
Journal: Blood (2007)
Clinical Application of Massively Parallel Sequencing in the Diagnosis of Hereditary Hemolytic and Dyserythropoietic Anemias
Authors: Harry Lesmana, Georgios E Christakopoulos, Katie Giger Seu, Mary Risinger, Hatice Duzkale, Neha Dagaonkar, Kejian Zhang, Theodosia A Kalfa
Journal: Blood (2016)
Long-Term Results of Non- Fludarabine Versus Fludarabine-Based Conditioning Regimens in Severe Aplastic Anemia Patients
Authors: Elifcan Aladag, Haluk Demiroglu, Rafiye Ciftciler, Yahya Buyukasik, Nilgun Sayinalp, Salih Aksu, Ibrahim Celalettin Haznedaroglu, Osman Ozcebe, Nelson J. Chao, Hakan Goker
Journal: Blood (2018)
CD8+ T Cells Engineered to Express a ROR1-Specific Chimeric Antigen Receptor Specifically Recognize ROR1 Positive B Cell Tumors.
Authors: Michael Hudecek, Thomas M Schmitt, Sivasubramanian Baskar, Wen-Chung Chang, David G Maloney, Michael C Jensen, Christoph M. Rader, Stanley Riddell
Journal: Blood (2009)
Safety and Efficacy of Dasatinib Versus Imatinib by Baseline Cardiovascular Comorbidity In Patients with Chronic Myeloid Leukemia In Chronic Phase (CML-CP): Analysis of the DASISION Trial
Authors: Giuseppe Saglio, Andreas Hochhaus, Jorge E. Cortes, Hagop Kantarjian, Michele Baccarani, M. Brigid Bradley-Garelik, David Dejardin, Neil P. Shah
Journal: Blood (2010)
Preclinical Studies of Salinomycin In Multiple Myeloma (MM) Models: Targeting of Side Population (SP) Cells In the Context of Tumor – Microenvironment Interactions.
Authors: Efstathios Kastritis, Jana Jakubikova, Jake Delmore, Steffen Klippel, Douglas W. McMillin, Melissa Ooi, Hannah M. Jacobs, Jacob P. Laubach, Paul G Richardson, Kenneth C. Anderson, Andrew L. Kung, Constantine S. Mitsiades
Journal: Blood (2010)
B-Cell Chronic Lymphocytic Leukemia (B-CLL) Cells Unresponsive to CD180 Ligation Fail to Respond to Anti-IgM Stimulation as Well
Authors: Nino Porakishvili, Peter Lydyard, Anna Bremser, Ketki Vispute, Azka Memon, Nina Kulikova, Edward Clarke, Kanti R Rai, Amit Nathwani, Rajendra N Damle, Nicholas Chiorazzi
Journal: Blood (2010)
Higher Mortality Rates in Breast and Lung Cancer Patients Admitted for Febrile Neutropenia: An Analysis of Outcomes Based on Data from the Nationwide Inpatient Sample from 2006-2013
Authors: Ankit Shah, Stuthi Perimbeti, Sumera Bukhari, Michael Wismer, Jordan Senchak, Luiz Marconcini, William Lee, Kristine Ward, Michael Styler, Maneesh Jain
Journal: Blood (2016)
CD38 Expression On CD34+ Cells as a Single Flow Cytometric Parameter to Distinguish Myelodysplastic Syndromes (MDS) From Non-Clonal Cytopenias.
Authors: Canan Alhan, Theresia M Westers, Claudia Cali, Gert J Ossenkoppele, Arjan A van de Loosdrecht
Journal: Blood (2009)
Molecular and Clinical Characterization of Patients with Myeloid Neoplasms Carrying the 12p Deletion
Authors: Vera Adema, Cassandra M. Hirsch, Bartlomiej P Przychodzen, Andrea Pellagatti, Jacqueline Boultwood, Aziz Nazha, Hetty E. Carraway, Francesc Sole, Mikkael A. Sekeres, Valeria Visconte, Jaroslaw P. Maciejewski
Journal: Blood (2016)
Effectiveness of BRAF inhibitors in patients with BRAF V600 mutation positive glioma: a systematic review
Authors: Ian Yao, Sarah Dawson, Julian Higgins, Luke McGuinness, Alexandra McAleenan, Kathreena M Kurian
Journal: Neuro-Oncology (2019)

Abstract Background BRAF inhibitor treatment with vemurafenib and dabrafenib have produced significant increases in median overall survival for BRAF V600 mutation-positive melanoma patients and are in wide clinical use. BRAF inhibitors have also been used in an ad hoc fashion in BRAF V600 mutation-positive glioma in a number of glioma subtypes with varying prognoses. Methods An electronic search was performed on MEDLINE and Embase on February 1, 2019 to identify studies of any design that reported the outcome of patients with BRAF V600 mutation-positive glioma treated with BRAF inhibitors. Data was collected for demographic information, tumour information (type and grading), BRAF mutation type, prior treatment regimens, type of BRAF inhibitor, dose and duration of treatment, best objective response, progression free survival (PFS), overall survival (OS), glioma specific symptomatic relief and adverse events. Preliminary Results Seventy-nine case reports, case series and single arm cohort studies with a total of 286 patients were included. Duration of treatment was available for 197 patients and varied from 0.1 to 54 months, with 104 patients still undergoing treatment at the time of publication. Progression occurred in 158 patients (including both low-grade and high-grade glioma) at between 0.805 and 36 months following the start of treatment. 34 people died, at between 0.329 and 40.1 months following the start of treatment. Conclusions Our systematic review shows varying clinical effectiveness of BRAF inhibitors in BRAF V600 mutation-positive glioma depending on low-grade or high-grade glioma. This evidence may inform future trials of BRAF inhibitors for glioma patients.
Orbital Non Hodgkin’s Lymphoma (NHL): A Large Monocentric Study of Initial Characteristics, Natural History and Prognostic Factors.
Authors: Meunier Jerome, Lumbroso Livia, Dendale Remy, Vincent-Salomon Anne, Asselain Bernard, Nemati Fariba, Chaoui Driss, Fourquet Alain, Desjardins Laurence, Plancher Corine, Decaudin Didier
Journal: Blood (2004)
Cooperative Activity of BRAF F595L and Mutant HRAS in Histiocytic Sarcoma Provides New Insights into Oncogenic BRAF Signaling
Authors: Maximilian Kordes, Michael Röring, Christoph Heining, Sandra Braun, Barbara Hutter, Daniela Richter, Christina Geörg, Claudia Scholl, Wilfried Roth, Andreas Rosenwald, Eva Geissinger, Christof von Kalle, Dirk Jäger, Benedikt Brors, Wilko Weichert, Carsten Grüllich, Hanno Glimm, Tilman Brummer, Stefan Fröhling
Journal: Blood (2015)