tbuckley/cabot-search huggingface dataset:
Abstract 21282: CD14 is a Key Mediator of Foam Cell Formation Induced by Lysophosphatidic Acid and Lipopolysaccharide
Authors: Dong An, Feng Hao, Fuqiang Zhang, Xuemin Xu, Mei-Zhen Cui
Journal: Circulation (2017)

Lysophosphatidic acid (LPA), a simple lysophospholipid, has potent effects on a variety of cell types. We report here that LPA enhances lipopolysaccharide (LPS)-induced oxidized low density lipoprotein (oxLDL) uptake in mouse primary bone marrow-derived macrophages (BMMs). Our data revealed that both LPA and LPS highly induce the CD14 expression at both messenger RNA and protein levels in BMMs. The role of CD14, one component of the LPS receptor cluster, in LPA-induced biological functions has been unknown. We took several steps to examine the role of CD14 in LPA signaling pathways. Knockdown of CD14 expression nearly completely blocked LPA-, LPS- or LPA plus LPS-induced oxLDL uptake in BMMs, demonstrating for the first time that CD14 is a key mediator responsible for both LPA- and LPS-induced oxLDL uptake/foam cell formation. To determine the molecular mechanism mediating CD14's novel function, we demonstrated that both LPA and LPS significantly induce the scavenger receptor A-1 (SR-AI) expression, and depletion of CD14 levels blocked LPA/LPS-induced SR-AI expression. We further showed that the SR-AI specific antibody, which quenches SR-AI function, blocked LPA and LPS-induced foam cell formation. Thus, SR-AI is the downstream mediator of CD14 in regulating LPA-, LPS-, and LPA/LPS-induced foam cell formation. Taken together, our results provide the first experimental evidence that CD14 is a novel junctional molecule connecting both LPA and LPS pathways and is a key mediator responsible for both LPA- and LPS-induced foam cell formation. The LPA/LPS-CD14-SR-AI nexus might be the new convergent pathway, contributing to the worsening of atherosclerosis.
Standardisation of the Parent Report of Children's Abilities–Revised (PARCA-R): a norm-referenced assessment of cognitive and language development at age 2 years
Authors: Samantha Johnson, Vasiliki Bountziouka, Peter Brocklehurst, Louise Linsell, Neil Marlow, Dieter Wolke, Bradley N Manktelow
Journal: The Lancet Child & Adolescent Health (2019)
Publisher Correction: Molecular and functional variation in iPSC-derived sensory neurons
Authors: Jeremy Schwartzentruber, Stefanie Foskolou, Helena Kilpinen, Julia Rodrigues, Kaur Alasoo, Andrew J. Knights, Minal Patel, Angela Goncalves, Rita Ferreira, Caroline Louise Benn, Anna Wilbrey, Magda Bictash, Emma Impey, Lishuang Cao, Sergio Lainez, Alexandre Julien Loucif, Paul John Whiting, Alex Gutteridge, Daniel J. Gaffney
Journal: Nature Genetics (2019)
Collaborative patterns, authorship practices and scientific success in biomedical research: a network analysis
Authors: Vanash M Patel, Pietro Panzarasa, Hutan Ashrafian, Tim S Evans, Ali Kirresh, Nick Sevdalis, Ara Darzi, Thanos Athanasiou
Journal: Journal of the Royal Society of Medicine (2019)

Summary Objective To investigate the relationship between biomedical researchers' collaborative and authorship practices and scientific success. Design Longitudinal quantitative analysis of individual researchers' careers over a nine-year period. Setting A leading biomedical research institution in the United Kingdom. Participants Five hundred and twenty-five biomedical researchers who were in employment on 31 December 2009. Main outcome measures We constructed the co-authorship network in which nodes are the researchers, and links are established between any two researchers if they co-authored one or more articles. For each researcher, we recorded the position held in the co-authorship network and in the bylines of all articles published in each three-year interval and calculated the number of citations these articles accrued until January 2013. We estimated maximum likelihood negative binomial panel regression models. Results Our analysis suggests that collaboration sustained success, yet excessive co-authorship did not. Last positions in non-alphabetised bylines were beneficial for higher academic ranks but not for junior ones. A professor could witness a 20.57% increase in the expected citation count if last-listed non-alphabetically in one additional publication; yet, a lecturer suffered from a 13.04% reduction. First positions in alphabetised bylines were positively associated with performance for junior academics only. A lecturer could experience a 8.78% increase in the expected citation count if first-listed alphabetically in one additional publication. While junior researchers amplified success when brokering among otherwise disconnected collaborators, senior researchers prospered from socially cohesive networks, rich in third-party relationships. Conclusions These results help biomedical scientists shape successful careers and research institutions develop effective assessment and recruitment policies that will ultimately sustain the quality of biomedical research and patient care.
Contrast-enhanced harmonic endoscopic ultrasound-guided ethanol injection for a small hepatocellular carcinoma
Authors: Andrea Lisotti, Fabio Piscaglia, Pietro Fusaroli
Journal: Endoscopy (2019)

Locoregional ablation represents the mainstay approach for early hepatocellular carcinoma (HCC). Percutaneous treatments are performed under ultrasound guidance to select a safe window to reach the nodule with a dedicated device [1].
Abstract 20776: Desmosomal Gene Mutations Perturb Myocardial Differentiation Through Complex Effects On Wnt Signaling
Authors: Eva Plovie Buys, Daniela Panáková, ZhenZhen Liu, Angeliki Asimaki, Andreas A Werdich, Ward Capoen, Jeffrey E Saffitz, Calum A MacRae
Journal: Circulation (2010)

Introduction: Mutations in desmosomal protein genes cause Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC). Prior work has raised inhibition of canonical Wnt signaling as a potential disease ...
Reimbursing Patients for Participation in Cancer Clinical Trials
Authors: Joseph M. Unger, Mark E. Fleury
Journal: JAMA Oncology (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Corrections to “Mapping unmet supportive care needs, quality-of-life perceptions and current symptoms in cancer survivors across the Asia-Pacific region: results from the International STEP Study”
Authors: A. Molassiotis, P. Yates, Q. Li, W.K.W. So, K. Pongthavornkamol, P. Pittayapan, H. Komatsu, M. Thandar, M. Yi, S. Titus Chacko, V. Lopez, J. Butcon, D. Wyld, R.J. Chan
Journal: Annals of Oncology (2018)

Ann Oncol 2017; 28: 2552–2558 (doi: 10.1093/annonc/mdx350) In the original article, there were some errors in the numbers and accompanying text in the Abstract. These have now been corrected to match the numbers in the rest of the Article. Author M.-S. Li's name has been corrected to M. Yi and affiliation 7 has also been corrected to add ‘Mahidol University, Bangkok’ after ‘Faculty of Nursing’. Mapping unmet supportive care needs, quality-of-life perceptions and current symptoms in cancer survivors across the Asia-Pacific region: results from the International STEP StudyAnnals of OncologyVol. 28Issue 10PreviewTo assess the supportive care needs, quality of life (QoL) and symptoms of patients with cancer after the end of first-line treatments and into survivorship in Asian countries using Australian data as benchmark. Full-Text PDF Open Archive
Some tricks for lumen-apposing metal stents: placement in benign esophageal strictures and a technique for reuse after complete misplacement
Authors: Ramon Sanchez-Ocana, Marcos Jimenez-Palacios, Ana Carbajo-Lopez, Irene Penas-Herrero, Paula Gil-Simon, Carlos de la Serna-Higuera, Manuel Perez-Miranda
Journal: Endoscopy (2019)

Lumen-apposing metal stents (LAMSs) are increasingly being used in our day-to-day practice. Endoscopists are beginning to gain experience not only in their placement but also in the errors or complications that can occur during their release, which may result in failure of the procedure or the need to use a new stent, with a consequent increase in the costs of the procedure. One specific case is complete malpositioning of a stent, meaning the complete opening of the metal without it reaching the target that is being pursued. In most cases, this forces one into having to use a new LAMS or another type of stent.
Novel laparo-endoscopic hybrid procedure to treat a disconnected Roux limb after bariatric surgery
Authors: Newton Teixeira dos Santos, Diogo Turiani Hourneaux De Moura, Manoel Galvão Neto, Flaubert Sena de Medeiros, Mário Victor Faria Nogueira, Christopher C. Thompson
Journal: Endoscopy (2019)

Obesity is a worldwide pandemic and bariatric surgery is the most effective treatment modality. Despite its satisfactory clinical results, some patients regain some of their lost weight [1] [2]. Traditionally, revisional surgery to reduce the gastrojejunal anastomosis (GJA) is offered to these patients. However, revisional procedures carry a higher complication rate than primary bariatric surgeries, including fistulas and dehiscence with incidences ranging from 1 % to 8.3 % after laparoscopic Roux-en-Y gastric bypass (RYGB) [2] [3] [4]. The diagnosis and treatment of bariatric surgery leaks are challenging due to nonspecific clinical and laboratory findings. Some cases are associated with situations of extreme gravity, narrowing the options for treatment and thus making the complications challenging to solve [5].
Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation
Authors: Yang Su, Jinling Huang, Xiaohong Zhao, Huiping Lu, Wang Wang, Xuexian O. Yang, Yuling Shi, Xiaohu Wang, Yuping Lai, Chen Dong
Journal: Science Immunology (2019)

T helper 17 (TH17) cells and interleukin-17A (IL-17A) produced by them are critical in autoinflammatory diseases, such as psoriasis. IL-17A has been shown to signal through IL-17 receptor A/IL-17 receptor C (IL-17RA/IL-17RC) complex to drive inflammatory responses. However, in a psoriasis model, we found that Il17rc deficiency did not completely ameliorate the disease, suggesting another receptor. In search for another IL-17A-interacting receptor, we found that IL-17RD directly bound IL-17A but not IL-17F or IL-17A/F heterodimer and formed a heterodimer with IL-17RA. IL-17A-, but not IL-17F- or IL-17A/F-, mediated gene expression was defective in Il17rd-deficient keratinocytes. Il17rd deficiency in nonhemopoietic cells attenuated imiquimod-induced psoriasis-like skin inflammation. Although IL-17RC and IL-17RD differentially activated IL-17A-dependent signaling and gene expression, their compound mutation led to complete deficits in keratinocytes. IL-23 was found induced by IL-17A in keratinocytes, dependent on both IL-17RC and IL-17RD, suggesting feed-forward regulation of IL-23/IL-17 axis in psoriasis. Together, IL-17RD constitutes a second functional receptor for IL-17A and, together with IL-17RC, mediates the proinflammatory gene expression downstream of IL-17A.
"in the Patients' Hands"- a Structured Survey of Patient Voices to Prioritise Research Questions in Rare Inherited Anaemias: The James Lind Alliance Priority Setting Partnership
Authors: Jenny Welch, Nick Meade, Dominic Messenger, Amy Hunter, Anupama Rao, Subarna Chakravorty, Rachel Wearmouth, Anju Chalin, Kristina Staley, Sheela Upadhyaya, Irene Roberts, Noemi Roy
Journal: Blood (2018)
Epidemiology of injuries in professional football: a systematic review and meta-analysis
Authors: Alejandro López-Valenciano, Iñaki Ruiz-Pérez, Alberto Garcia-Gómez, Francisco J Vera-Garcia, Mark De Ste Croix, Gregory D Myer, Francisco Ayala
Journal: British Journal of Sports Medicine (2019)

We performed a systematic review and meta-analysis of epidemiological data of injuries in professional male football.
Late Relapses in Patients With Diffuse Large B-Cell Lymphoma Treated With Immunochemotherapy
Authors: Yucai Wang, Umar Farooq, Brian K. Link, Melissa C. Larson, Rebecca L. King, Matthew J. Maurer, Cristine Allmer, Mehrdad Hefazi, Carrie A. Thompson, Ivana N. Micallef, Patrick B. Johnston, Thomas M. Habermann, Thomas E. Witzig, Stephen M. Ansell, James R. Cerhan, Grzegorz S. Nowakowski
Journal: Journal of Clinical Oncology (2019)

In patients with diffuse large B-cell lymphoma (DLBCL), most relapses occur within the first 2 years of diagnosis. We sought to define the rate and outcome of late relapses that occurred after achieving event-free survival at 24 months (EFS24).
Abstract 17701: Nrf2 Inhibits NF-κB Activation During Ischemia Reperfusion Injury and Suppresses Subsequent Development of Cardiac Allograft Vasculopathy in Murine Heart Transplantation
Authors: Hiroyuki Kawajiri, Arash Ghashghai, Laura Tumiati, Julieta Lazarte, Liza Grosman-Rimon, Vanessa R Luengas, Mitesh Badiwala, Jagdish Butany, Renke Li, Filio Billia, Vivek Rao
Journal: Circulation (2015)

Introduction: Recent studies suggest that ischemia reperfusion injury (IRI) activates the NF-κB pathway leading to the subsequent development of cardiac allograft vasculopathy (CAV). Nrf2 has been suggested to inhibit NF-κB activation during IRI in other organs; however, the role in myocardial IRI and CAV remains unclear. Therefore, we examined the effects of Nrf2 induction and knockout (KO) on IRI-mediated NF-κB activation as well as CAV using a murine transplant (Tx) model. Methods: Nrf2 wild-type (WT) and KO mice were used as donors, with WTs used as recipients for IRI studies and Bm12 mice for CAV studies. Donor hearts received 2hrs of cold ischemia before Tx. Twenty-five mg/kg sulforaphane (SF, a known Nrf2 agonist) was given to donors 24hrs prior to surgery and to recipients just after Tx to induce Nrf2, with saline as vehicle control (SA). Donor hearts were procured after 24hrs of reperfusion in IRI studies. In CAV studies, recipients received daily 5mg/kg SFN or saline until day 56 when donor hearts were procured (n=6/group). Results: In IRI, NF-κB activity measured by percentage of the cells with nuclear p65 (Figure A) was significantly higher in KO-SA compared with WT-SA (38±4 vs 24±4%, p&lt;0.001). WT-SF displayed notably less NF-κB activity compared with WT-SA (13±5 vs 24±4%, p=0.002). The mRNA levels of NF-κB-mediated inflammatory cytokines were significantly higher in KO-SA compared with WT-SA, and WT-SF displayed lower levels of these mRNA compared with WT-SA (Figure B). In the chronic CAV studies, WT-SA displayed less coronary occlusion area compared with KO-SA (21±8 vs 42±12%, p=0.005). Furthermore, WT-SF showed significantly less coronary occlusion compared with WT-SA (21±8 vs 8±4%, p=0.005) (Figure C). Conclusions: Our results suggest that Nrf2 inhibits NF-κB activation during IRI and suppresses subsequent development of CAV. The Nrf2 pathway may be a promising pharmacological target to prevent development of CAV via its anti-inflammatory properties.
Combined GLP-1, Oxyntomodulin, and Peptide YY Improves Body Weight and Glycemia in Obesity and Prediabetes/Type 2 Diabetes: A Randomized, Single-Blinded, Placebo-Controlled Study
Authors: Preeshila Behary, George Tharakan, Kleopatra Alexiadou, Nicholas Johnson, Nicolai J. Wewer Albrechtsen, Julia Kenkre, Joyceline Cuenco, David Hope, Oluwaseun Anyiam, Sirazum Choudhury, Haya Alessimii, Ankur Poddar, James Minnion, Chedie Doyle, Gary Frost, Carel Le Roux, Sanjay Purkayastha, Krishna Moorthy, Waljit Dhillo, Jens J. Holst, Ahmed R. Ahmed, A. Toby Prevost, Stephen R. Bloom, Tricia M. Tan
Journal: Diabetes Care (2019)

OBJECTIVE Roux-en-Y gastric bypass (RYGB) augments postprandial secretion of glucagon-like peptide 1 (GLP-1), oxyntomodulin (OXM), and peptide YY (PYY). Subcutaneous infusion of these hormones (“GOP”), mimicking postprandial levels, reduces energy intake. Our objective was to study the effects of GOP on glycemia and body weight when given for 4 weeks to patients with diabetes and obesity. RESEARCH DESIGN AND METHODS In this single-blinded mechanistic study, obese patients with prediabetes/diabetes were randomized to GOP (n = 15) or saline (n = 11) infusion for 4 weeks. We also studied 21 patients who had undergone RYGB and 22 patients who followed a very low-calorie diet (VLCD) as unblinded comparators. Outcomes measured were 1) body weight, 2) fructosamine levels, 3) glucose and insulin during a mixed meal test (MMT), 4) energy expenditure (EE), 5) energy intake (EI), and 6) mean glucose and measures of glucose variability during continuous glucose monitoring. RESULTS GOP infusion was well tolerated over the 4-week period. There was a greater weight loss (P = 0.025) with GOP (mean change −4.4 [95% CI −5.3, −3.5] kg) versus saline (−2.5 [−4.1, −0.9] kg). GOP led to a greater improvement (P = 0.0026) in fructosamine (−44.1 [−62.7, −25.5] µmol/L) versus saline (−11.7 [−18.9, −4.5] µmol/L). Despite a smaller weight loss compared with RYGB and VLCD, GOP led to superior glucose tolerance after a mixed-meal stimulus and reduced glycemic variability compared with RYGB and VLCD. CONCLUSIONS GOP infusion improves glycemia and reduces body weight. It achieves superior glucose tolerance and reduced glucose variability compared with RYGB and VLCD. GOP is a viable alternative for the treatment of diabetes with favorable effects on body weight.
Abstract 226: Comparison of a Low and High Resource Model to Effectively Train College Students in Compression Only Cardiopulmonary Resuscitation
Authors: Matthias Goldstein, Benjamin Goldstein, Joel Novograd, Kailah Carden, Michelle Kirwan
Journal: Circulation (2018)

Introduction: High quality chest compressions, as measured by depth and rate per minute, are an integral component of cardiopulmonary resuscitation (CPR). CPR compression skills are often taught on a high resource training device such as manikin torso. Use of these manikin torso devices may be limited by availability and cost, reducing the number of individuals trained in CPR. We hypothesize that a bed pillow, a low resource device, is as effective as a manikin torso, a high resource device, in training college students to perform compression only CPR. Methods: College students with no prior CPR training were randomized to one of two training rooms, one with a bed pillow (n=119) and one with a manikin torso (n=123). Each participant watched a two- minute training video, which included a demonstration using the respective device and a practice-while-watching technique chest compression skills practice. Each room had a certified CPR instructor to assist and answer any technical questions. Another CPR instructor, blinded to the training randomizations, observed each participant for one minute on a recording manikin that evaluated the depth and rate of compressions. Results: Manikin-trained students had a significantly higher mean rate of compressions per minute compared to the pillow-trained students (122.9 vs. 118.0; p= 0.028). The manikin group exceeded the recommended rate range (100-120 compressions per minute). There was no significant difference between compression depth in the two groups; manikin-trained students had an average compression depth of 38.27 mm while pillow-trained students had an average compression depth of 38.50 mm (p=0.89). Mean compression depth for both groups were below the guidelines (50-61 mm).There was no significant difference (p=0.81) between the overall CPR competency of the pillow-trained compared to the manikin-trained students as measured by rate and depth of compressions. Conclusions: These findings demonstrate that a low resource pillow is comparable to a high resource manikin as a CPR training device. The use of a low resource training device can remove the barriers of cost and availability in training college students in CPR. This training method will allow for an increase in the number of people trained to save lives.
NHS workforce plan: Doctors will be able to halve pension contributions to ease tax burden
Authors: Elisabeth Mahase
Journal: BMJ (2019)

Senior clinicians such as GPs and consultants will be able to halve their pension contributions to avoid significant tax charges, under new proposals outlined by the government.1

The new “50:50” offer, unveiled as part of the long awaited interim workforce plan for the NHS in England, will afford doctors new flexibility to halve the rate of their pension growth in exchange for halving their contributions to the NHS pension scheme. Currently, the NHS scheme does not offer any flexibility in the rate at which the pension builds, with the highest earning consultants contributing 14.5% of their pensionable pay each month.

This has led to doctors taking early retirement or cutting clinical hours, as they are unable to control their contributions and thus exceed the pensions allowance, which limits what NHS staff can pay into their pensions before tax charges apply. This has left many facing large tax bills.2 …
Anti‐GM‐CSF therapy in psoriasis
Authors: K.A. Papp, M. Gooderham, R. Jenkins, R. Vender, J.C. Szepietowski, T. Wagner, B. Hunt, B. Souberbielle
Journal: British Journal of Dermatology (2019)

Psoriasis is a long‐lasting disease involving inflammation of the skin. In the most common form of this disease ‐ plaque psoriasis ‐ the inflammation is visible as raised, reddened and often scaly areas which may extend widely over the body. Although not generally a life‐threatening condition, psoriasis may increase the risk of other serious disorders (such as cardiovascular disease), and often leads to much reduced quality of life for patients ‐ through physical discomfort (itching, pain), disability, and related emotional trauma. Furthermore, psoriasis occurs worldwide (affecting up to 3% of the populations in various countries) and cannot be completely cured by available treatments. Together, these issues make the disease a serious global burden. Granulocyte‐Macrophage Colony‐Stimulating Factor (GM‐CSF) is made in the body and is important in controlling functions of the body's immune system and the processes involved in inflammation. Therefore, this study was carried out to establish whether blocking the activities of GM‐CSF in patients with moderate or severe plaque psoriasis could result in significant improvement of the disease. In total, 122 patients were enrolled from Canada, Denmark, Germany, Latvia and Poland. The patients were treated over 10 weeks either with namilumab (GM‐CSF blocker) or a placebo (inactive): assessments of their psoriasis were made during this period, and completed after an additional 2 weeks. Notably, throughout the 12‐week study duration no significant improvement was detected for namilumab‐treated patients ‐ in marked contrast to treatment benefit found in a similar study involving patients with rheumatoid arthritis. These findings point to different roles for GM‐CSF in the two diseases, and suggest that blocking GM‐CSF activity alone is not enough for effective treatment of plaque psoriasis.