tbuckley/cabot-search huggingface dataset:
Discrepancies in Financial Self-Disclosures and Open Payments Reporting Among Authors of Clinical Oncology Research Studies
Authors: Elizabeth Garrett-Mayer, Melinda W. Kaltenbaugh, Rebecca Spence, Suanna S. Bruinooge, Clifford A. Hudis, Dina Michels, Richard L. Schilsky
Journal: Journal of Clinical Oncology (2019)

Company-reported payments from the Open Payments database (OP) have been compared with self-disclosed financial relationships made by physician authors. Discrepancies have been viewed as under-reporting of financial relationships. Our goal was to perform a systematic comparison to determine sources of discordance between company-reported and self-reported financial relationships.Financial disclosures reported by 163 authors and presenters who published in Journal of Clinical Oncology or who presented an abstract at the ASCO 2018 Annual Meeting were obtained and matched to payment data in OP. Categories included ownership, research, consulting/services, honoraria, expenses, royalty/patent/intellectual property, and other disclosures. Measures of concordance and discordance were calculated on the basis of matches on both company and category of disclosure and matches on company. Results are reported overall and within certain categories of disclosures.Overall concordance between disclosures to ASCO and payments in OP was 16% for company and category matching and 24% for matching on the basis of company only. Authors tended to report more disclosures for research and consulting to ASCO than appear in OP. Expense disclosures were more frequently reported in OP than to ASCO. No payments were categorized as ownership in OP, but 35 authors/presenters disclosed ownership (including stock) to ASCO.Our results reveal substantial discordance between self-reported and company-reported financial relationships for authors who report clinical oncology research. These findings support the calls for development of standardized disclosure policies across medicine.
Association Between Breastfeeding and Postpartum Multiple Sclerosis Relapses
Authors: Kristen M. Krysko, Alice Rutatangwa, Jennifer Graves, Ann Lazar, Emmanuelle Waubant
Journal: JAMA Neurology (2019)

<h3>Importance</h3> Multiple sclerosis (MS) relapses may be increased in the postpartum period, and whether breastfeeding is associated with reduction in the risk of postpartum relapses remains controversial. <h3>Objective</h3> To perform a systematic review and meta-analysis to evaluate whether breastfeeding is associated with reduction in postpartum MS relapses compared with not breastfeeding. <h3>Data Sources</h3> PubMed and Embase were searched for studies assessing the association between breastfeeding and MS disease activity published between January 1, 1980, and July 11, 2018, as well as reference lists of selected articles. <h3>Study Selection</h3> All study designs assessing the association between breastfeeding and postpartum relapses in MS relative to a comparator group were included. <h3>Data Extraction and Synthesis</h3> Study eligibility assessment and extraction of study characteristics, methods, and outcomes, were performed independently by 2 reviewers following PRISMA guidelines. Risk of bias was evaluated by 2 independent reviewers with the ROBINS-I tool for nonrandomized, interventional studies. Findings from studies with data available for the number of women with postpartum relapses in the breastfeeding and nonbreastfeeding groups were combined with a random-effects model. <h3>Main Outcomes and Measures</h3> Postpartum MS relapse. <h3>Results</h3> The search identified 462 unique citations, and 24 (2974 women) satisfied eligibility criteria and were included, of which 16 were included in the quantitative meta-analysis. The pooled summary odds ratio for the association of breastfeeding with postpartum relapses was 0.63 (95% CI, 0.45-0.88;<i>P</i> = .006) compared with a reference of nonbreastfeeding. Pooled adjusted hazard ratio across 4 studies that reported this finding was 0.57 (95% CI, 0.38-0.85;<i>P</i> = .006). There was moderate heterogeneity (<i>I</i><sup>2</sup> = 48%), which was explained by variable prepregnancy relapse rate, postpartum follow-up duration, and the publication year. A stronger association was seen in studies of exclusive rather than nonexclusive breastfeeding, although both demonstrated an association. Studies were rated at moderate and serious risk of bias, with concern for residual confounding, although sensitivity analysis including only moderate quality studies was consistent with a protective outcome of breastfeeding. <h3>Conclusions and Relevance</h3> These findings suggest that breastfeeding is protective against postpartum relapses in MS, although high-quality prospective studies to date are limited and well-designed observational studies that aim to emulate a randomized trial would be of benefit.
Second cancers in MPN: Survival analysis from an international study
Authors: Monia Marchetti, Arianna Ghirardi, Arianna Masciulli, Alessandra Carobbio, Francesca Palandri, Nicola Vianelli, Elena Rossi, Silvia Betti, Ambra Di Veroli, Alessandra Iurlo, Daniele Cattaneo, Guido Finazzi, Massimiliano Bonifacio, Luigi Scaffidi, Andrea Patriarca, Elisa Rumi, Ilaria Carola Casetti, Clemency Stephenson, Paola Guglielmelli, Elena Maria Elli, Miroslava Palova, Davide Rapezzi, Daniel Erez, Montse Gomez, Kai Wille, Manuel Perez‐Encinas, Francesca Lunghi, Anna Angona, Maria Laura Fox, Eloise Beggiato, Giulia Benevolo, Giuseppe Carli, Rossella Cacciola, Mary Frances McMullin, Alessia Tieghi, Valle Recasens, Susanne Isfort, Fabrizio Pane, Valerio De Stefano, Martin Griesshammer, Alberto Alvarez‐Larran, Alessandro Maria Vannucchi, Alessandro Rambaldi, Tiziano Barbui
Journal: American Journal of Hematology (2019)

One out of ten patients with Philadelphia-negative myeloproliferative neoplasms (MPN) develop a second cancer (SC): in such patients we aimed at assessing the survival impact of SC itself and of MPN-specific therapies. Data were therefore extracted from an international nested case-control study, recruiting 798 patients with SC diagnosed concurrently or after the MPN. Overall, 2995 person-years (PYs) were accumulated and mortality rate (MR) since SC diagnosis was 5.9 (5.1-6.9) deaths for every 100 PYs. A "poor prognosis" SC (stomach, esophagus, liver, pancreas, lung, ovary, head-and-neck or nervous system, osteosarcomas, multiple myeloma, aggressive lymphoma, acute leukemia) was reported in 26.3% of the patients and was the cause of death in 65% of them (MR 11.0/100 PYs). In contrast, patients with a "non-poor prognosis" SC (NPPSC) incurred a MR of 4.6/100 PYs: 31% of the deaths were attributed to SC and 15% to MPN evolution. At multivariable analysis, death after SC diagnosis was independently predicted (HR and 95% CI) by patient age greater than 70 years (2.68; 1.88-3.81), the SC prognostic group (2.57; 1.86-3.55), SC relapse (1.53; 10.6-2.21), MPN evolution (2.72; 1.84-4.02), anemia at SC diagnosis (2.32; 1.49-3.59), exposure to hydroxyurea (1.89; 1.26-2.85) and to ruxolitinib (3.63; 1.97-6.71). Aspirin was protective for patients with a NPPSC (0.60; 0.38-0.95). In conclusion, SC is a relevant cause of death competing with MPN evolution. Prospective data are awaited to confirm the role of cytoreductive and anti-platelet drugs in modulating patient survival after the occurrence of a SC.
Abstract 11299: A Novel Senolytic Drug for Aging and Age-Related Cardiometabolic Disorders
Authors: Goro Katsuumi, Ippei Shimizu, Yohko Yoshida, Yuka Hayashi, Ryutaro Ikegami, Masayoshi Suda, Takayuki Wakasugi, Masaaki Nakao, Tohru Minamino
Journal: Circulation (2018)

Accumulating evidence has revealed that cellular senescence plays a pivotal role in aging and age-related cardiometabolic disorders including atherosclerosis, heart failure and diabetes. Recently, ...
Origin of Europa and the Galilean Satellites
Authors: R. M. Canup, W. R. Ward
Journal: Eurosurveillance (2009)

Europa is believed to have formed near the very end of Jupiter's own accretion, within a circumplanetary disk of gas and solid particles. We review the formation of the Galilean satellites in the context of current constraints and understanding of giant planet formation, focusing on recent models of satellite growth within a circumjovian accretion disk produced during the final stages of gas inflow to Jupiter. In such a disk, the Galilean satellites would have accreted slowly, in more than 10^5 yr, and in a low pressure, low gas density environment. Gravitational interactions between the satellites and the gas disk lead to inward orbital migration and loss of satellites to Jupiter. Such effects tend to select for a maximum satellite mass and a common total satellite system mass compared to the planet's mass. One implication is that multiple satellite systems may have formed and been lost during the final stages of Jupiter's growth, with the Galilean satellites being the last generation that survived as gas inflow to Jupiter ended. We conclude by discussing open issues and implications for Europa's conditions of formation.
Statistical Correlations Between Quantifiable Disease Variables and Prognosis in Hematological Malignancy Patients Treated with Itraconazole as An Empirical Antifungal Therapy: A Prospective Multicenter Observational Study in Korea
Authors: Jin Seok Kim, Ho Jin Shin, June-Won Cheong, Jong Wook Lee, Kyoo Hyung Lee, Deok-Hwan Yang, Won-Sik Lee, Hawk Kim, Joon Seong Park, Sung Hyun Kim, Sang Min Lee, Eun-Kee Song, Yee Soo Chae, Jinny Park, Young Rok Do, Yoo Hong Min
Journal: Blood (2008)
Abstract 11139: Utility of Non-hdl-c and Apob Targets at Progressively Lower Ldl-c Down to Levels Less Than 40 Mg/dl
Authors: Vasanth Sathiyakumar, Jihwan Park, Aparna Sajja, Eliseo Guallar, Mariana Lazo, Steven R Jones, Seth S Martin
Journal: Circulation (2019)

Introduction: Patients on PCSK9 inhibitors routinely achieve LDL-C levels well below 70 mg/dL and often <40 mg/dL. It is unclear to what extent guideline-recommended secondary targets (non-HDL-C an...
Profilin is a marker of severity in allergic respiratory diseases
Authors: Javier Ruiz‐Hornillos, M. Angeles López‐Matas, Pilar Berges Jimeno, Aythamy Henríquez, Sandra Blanco, Marta Seoane‐Rodríguez, Ignacio Mahíllo, Jerónimo Carnés
Journal: Allergy (2019)

The capacity of profilin to induce allergic symptoms in patients with respiratory allergy has been questioned. In this sense, the aim of this study was to investigate the correlation between profilin exposure and induction of symptoms in a prospective case-control study.The concentration of profilin as well as pollen levels in the air was measured. A diary score of symptoms was collected from allergic patients. Seventy-nine individuals were included in the study; fifty cases and 28 controls were positive or negative to profilin, respectively. Conjunctival and bronchial provocation tests were performed with purified profilin (Pho d 2) in a subgroup of cases and controls.Profilin was detected in the environment on 133 days (maximum peak of 0.56 ng/m3 ). A positive correlation between profilin and pollen count of Olea and Poaceae was observed (ρ = 0.24; P < .001). Intensity of total, nasal and ocular symptoms was statistically higher in cases than in controls (P < .001). The risk of suffering symptoms, measured by the percentage of patients who presented any of the symptoms each day, was also higher in cases than in controls. The provocation test was positive in 95% of bronchial and 90% of conjunctival challenges in cases, and negative in all controls.Profilin was detected in the environment and had the ability to induce a specific allergen response. Patients sensitized to this panallergen showed more symptoms and were more likely to have symptoms. Therefore, sensitization to profilin seems to be a marker of severity in patients with rhinoconjunctivitis and asthma mediated by pollen.
Chondrocalcinosis of the Knee and the Risk of Osteoarthritis Progression: Data From the Knee and Hip Osteoarthritis Long‐term Assessment Cohort
Authors: Augustin Latourte, Anne‐Christine Rat, Willy Ngueyon Sime, Hang‐Korng Ea, Thomas Bardin, Bernard Mazières, Christian Roux, Francis Guillemin, Pascal Richette
Journal: Arthritis & Rheumatology (2019)

Objective To assess the impact of knee chondrocalcinosis ( CC ) on the 5‐year risk of joint replacement and disease progression in patients with knee osteoarthritis ( OA ). Methods Patients with symptomatic knee OA without previous total joint (knee or hip) replacement ( TJR ) were recruited from the Knee and Hip Osteoarthritis Long‐term Assessment cohort. Cox proportional hazards regression and generalized estimating equation models were used to compare the time from inclusion or OA diagnosis to total knee replacement ( TKR ) or TJR between patients with and those without knee CC at inclusion. In patients without incident TKR , logistic regression was performed to examine the association between CC and radiographic progression (Kellgren/Lawrence [K/L] grade) or worsening of Western Ontario and McMaster Universities Arthritis Index ( WOMAC ) subscores for OA pain or function between years 0 and 5. Hazard ratios ( HR s) and 95% confidence intervals (95% CI s) were estimated. Analyses were adjusted for age, sex, body mass index, WOMAC subscores, and K/L grade. Results Among the 656 patients included, 93 (14.2%) had knee CC , and 91 (13.9%) underwent TKR during the follow‐up. Risk of TKR was not affected by the presence of knee CC ( HR 1.26 [95% CI 0.74–2.17]). Similar results were obtained for the risk of incident TJR . For patients without incident TKR , knee CC did not affect the risk of worsening of K/L grade (odds ratio [ OR ] 0.9 [95% CI 0.4–1.7]), WOMAC pain subscore ( OR 1.1 [95% CI 0.7–1.4]), or WOMAC function subscore ( OR 0.9 [95% CI 0.4–2.0]). Conclusion In patients with symptomatic knee OA , the presence of knee CC did not affect the risk of arthroplasty or disease progression at 5 years.
Abstract 14428: Impairment of Endothelial Function by Aerosol From Marijuana Leaf Vaporizers
Authors: Jiangtao Liu, Pooneh Nabavizadeh, Poonam Rao, Ronak Derakhshandeh, Matthew L Springer
Journal: Circulation (2019)

Introduction: Marijuana leaf vaporizers, which gently heat leaves and sublimate THC without combustion, are popular alternatives to smoking cannabis. They are generally perceived as less harmful, b...
Impact of Sleep Deprivation on Respiratory Motor Output and Endurance. A Physiological Study
Authors: Christophe Rault, Aude Sangaré, Véronique Diaz, Stéphanie Ragot, Jean-Pierre Frat, Mathieu Raux, Thomas Similowski, René Robert, Arnaud W. Thille, Xavier Drouot
Journal: American Journal of Respiratory and Critical Care Medicine (2019)

Rationale: Sleep deprivation can alter endurance of skeletal muscles, but its impact on respiratory command is unknown.Objectives: We aimed to assess the effect of sleep deprivation on respiratory motor output and inspiratory endurance.Methods: Inspiratory endurance was investigated twice in random order, following a normal sleep night and a sleepless night. Healthy participants were asked to breathe as long as possible until task failure against a moderate inspiratory threshold constraint. Transdiaphragmatic pressure and diaphragm electrical activity were measured throughout the trial to assess pressure output of the diaphragm and overall respiratory motor output. Cortical contribution to respiratory motor output was assessed by measurement of preinspiratory motor potential amplitude and by cervical magnetic simulation.Measurements and Main Results: Twenty healthy male participants were studied. Time to task failure was significantly shorter after sleep deprivation than after normal sleep: (30 min [interquartile range [IQR], 17–41] vs. 60 min [IQR, 45–60], P = 0.002). At the beginning of the trial, preinspiratory motor potential amplitude was significantly lower in the sleep-deprivation condition (4.5 μV [IQR, 2.5–6.4] vs. 7.3 μV [IQR, 4.3–10.4], P = 0.02) and correlated significantly with the duration of the endurance trial. In the sleep-deprivation condition, preinspiratory motor potential amplitude, electrical activity of the diaphragm, pressure output of the diaphragm, and Vt decreased and the respiratory rate increased significantly from the beginning to the end of the trial. Such decreases did not occur in the normal-sleep condition.Conclusions: One night of sleep deprivation reduces respiratory motor output by altering its cortical component with subsequent reduction of inspiratory endurance by half. These results suggest that altered sleep triggers severe brain dysfunctions that could precipitate respiratory failure.
Preoperative pulmonary function tests do not predict the development of pulmonary complications after elective major abdominal surgery: A prospective cohort study
Authors: Shinichiro Yokota, Masaru Koizumi, Kazutomo Togashi, Mitsuaki Morimoto, Yoshikazu Yasuda, Naohiro Sata, Alan Kawarai Lefor
Journal: International Journal of Surgery (2019)
Purging "In Vivo" with Alemtuzumab (Campath-1H) before Autologous Stem Cell Transplantation (ASCT) in Chronic Lymphocytic Leukemia (CLL).
Authors: Marco Montillo, Alessandra Tedeschi, Roberto Cairoli, Sara Miqueleiz, Barbara Scarpati, Anna Maria Cafro, Liliana Intropido, Renata Farioli, Silvio Veronese, Enrica Morra
Journal: Blood (2005)
Randomized post-induction and delayed intensification therapy in high-risk pediatric acute lymphoblastic leukemia: long-term results of the international AIEOP-BFM ALL 2000 trial
Authors: Andishe Attarbaschi, Georg Mann, Martin Zimmermann, Peter Bader, Elena Barisone, Giuseppe Basso, Andrea Biondi, Gunnar Cario, Gianni Cazzaniga, Antonella Colombini, Christian Flotho, Michaela Kuhlen, Peter Lang, Melchior Lauten, Christin Linderkamp, Franco Locatelli, Luca Lo Nigro, Anja Möricke, Felix Niggli, Renate Panzer-Grümayer, Rosanna Parasole, Christina Peters, Maria Caterina Putti, Carmelo Rizzari, Meinolf Suttorp, Maria Grazia Valsecchi, Valentino Conter, Martin Schrappe
Journal: Leukemia (2019)
阴道分泌物——原因、诊断及治疗
Authors: HelenMitchell, 宋英娜, 潘凌亚
Journal: BMJ (2005)

阴道分泌物是医生在许多医疗服务(初级保健、妇科学、计划生育和泌尿生殖医学)中常见的一个症状。阴道分泌物可以是生理性的，也可以是病理性的。尽管异常的阴道分泌物常促使妇女去进行性传播感染(STIs)疾病的筛查，但阴道分泌物不足以预测STI是否存在。本文重点论述阴道分泌物的原因、诊断以及最常见感染病因的治疗。
Lay Responder Care for an Adult with Out-of-Hospital Cardiac Arrest
Authors: William J. Brady, Amal Mattu, Corey M. Slovis
Journal: New England Journal of Medicine (2019)

Lay responders play a major role in the resuscitation of persons with out-of-hospital cardiac arrest. Crucial steps include recognition of cardiac arrest, a call for emergency assistance, cardiopulmonary resuscitation, and use of an automated external defibrillator.
Phase II Study To Determine If Danazol Is an Anti-D Sparing Agent When Used in Combination with Anti-D for the Treatment of Immune Thrombocytopenic Purpura.
Authors: Ibrahim N. Nakhoul, Ilan Shapira, May Abdo-Matkiwsky, Peter Kozuch, Etta Frankel, Sree Bhavani Chalasani, Takhir Mirzoyev, Margaret Dietrich, Peter Homel, Michael L. Grossbard, Mala Varma
Journal: Blood (2006)
The European InCASA telecare-telehealth electronic platform (ICT-FP7) for the daily assessment of symptoms, weight, and activity in cancer patients on chronotherapy at home.
Authors: Francis Levi, Alexandre Arbaud, Garance Dispersyn, Jordi Rovira Simon, Pasquale F. Innominato, Rachel Bossevot, Magali Mocquery, Virginie Plessis, Jo Fursse, Massimo Caprino
Journal: Journal of Clinical Oncology (2012)

TPS9154 Background: Self-rated symptoms contribute to the Quality of Life (QoL) of cancer patients (pts) and impact on prognosis. Behavioural functions are controlled by the circadian timing system (CTS), through a network of molecular clocks that time cellular proliferation and drug metabolism (Lévi et al. ARPT 2010). Chronotherapy aims at the reduction of treatment-related symptoms through the adjustment of chemotherapy delivery to the CTS. Cancer chronotherapy is delivered at home using programmable pumps, and avoids familial and social disruption. Telemedicine tools can provide continuous information on symptoms, behavior, QoL and CTS from non hospitalized pts. Methods: The inCASA platform enables telemonitoring of multiple functions in order to help physicians to detect early warning signals in pt condition at home, and prompt adequate and timely interventions. Our pilot site investigates the clinical relevance of daily teletransmitted self assessed symptoms, body weight and rest-activity circadian rhythm in cancer pts. This system was first well understood and accepted by 14 pts (9 male, 5 female, 43-77 years) at the outpt clinic, then used by 5 pts (4 male, 1 female, 61±13 years) at home daily for 6+ weeks, while receiving chronotherapy. The pilot phase will accrue 30 pts receiving chronotherapy at home from 03/01/2012. Pts will fill in the M.D. Anderson Symptom Inventory scale on a touch-screen device, measure their body weight using a Bluetooth scale and record their circadian rest-activity rhythm using an infrared wrist-watch accelerometer over 6-weeks. The data are transmitted to the platform, then to a web portal with secured access to be daily inspected by the oncology nursing and medical team. The modelling of these continuous records will define alert thresholds for nurse-controlled graded intervention decisions. Conclusion: The assessment criteria set forth for the inCASA solution will address the issues of pt autonomy, CTS entrainment in the pt usual environment, safety of chronotherapy delivery at home and treatment costs. Its use should induce important organisational changes and perception in healthcare professionals.
Targeting Cancer Associated Fibroblasts in the Bone Marrow Prevents Resistance to Chimeric Antigen Receptor T Cell Therapy in Multiple Myeloma
Authors: Reona Sakemura, Michelle J. Cox, Michael J. Hansen, Mehrdad Hefazi, Claudia Manriquez Roman, Kendall J. Schick, Erin E. Tapper, Paulina Roman Moreno, Michael W. Ruff, Denise K Walters, Sameer A. Parikh, Neil E. Kay, Saad S. Kenderian
Journal: Blood (2019)
Point-of-care cervical cancer screening using deep learning-based microholography
Authors: Divya Pathania, Christian Landeros, Lucas Rohrer, Victoria D'Agostino, Seonki Hong, Ismail Degani, Maria Avila-Wallace, Misha Pivovarov, Thomas Randall, Ralph Weissleder, Hakho Lee, Hyungsoon Im, Cesar M. Castro
Journal: Theranostics (2019)

Most deaths (80%) from cervical cancer occur in regions lacking adequate screening infrastructures or ready access to them.In contrast, most developed countries now embrace human papillomavirus (HPV) analyses as standalone screening; this transition threatens to further widen the resource gap.Methods: We describe the development of a DNA-focused digital microholography platform for point-of-care HPV screening, with automated readouts driven by customized deep-learning algorithms.In the presence of high-risk HPV 16 or 18 DNA, microbeads were designed to bind the DNA targets and form microbead dimers.The resulting holographic signature of the microbeads was recorded and analyzed.Results: The HPV DNA assay showed excellent sensitivity (down to a single cell) and specificity (100% concordance) in detecting HPV 16 and 18 DNA from cell lines.Our deep learning approach was 120-folder faster than the traditional reconstruction method and completed the analysis in < 2 min using a single CPU.In a blinded clinical study using patient cervical brushings, we successfully benchmarked our platform's performance to an FDA-approved HPV assay.Conclusions: Reliable and decentralized HPV testing will facilitate cataloguing the high-risk HPV landscape in underserved populations, revealing HPV coverage gaps in existing vaccination strategies and informing future iterations.
Transcriptional Activation of the Cardiac Homeobox Gene CSX1/NKX2-5 in a B-Cell Chronic Lymphoproliferative Disorder.
Authors: Xinying Su, Maryvonne Busson, Eric Delabesse, Zahia Azgui, Roland Berger, Hélène Merle-Beral, Olivier A. Bernard, Florence Nguyen-Khac
Journal: Blood (2004)