tbuckley/cabot-search huggingface dataset:
Prevention of Graft-Versus-Host Disease by Inhibition of Lymphocyte Trafficking Using a CCR5 Antagonist
Authors: Ran Reshef, Selina M. Luger, Alison W. Loren, Noelle V. Frey, Steven C. Goldstein, Elizabeth O. Hexner, Edward A. Stadtmauer, Jacqueline Smith, Rosemarie Mick, Daniel F. Heitjan, Susan E. Shetzline, Gwenn-ael H. Danet-Desnoyers, Stephen G. Emerson, James A. Hoxie, Robert H. Vonderheide, David L. Porter
Journal: Blood (2010)
TOSO Deficiency Exerts Impact On BAFF-R Expression, Thereby Causing Impaired B Cell Development in Vivo
Authors: Alexandra Schulz, Yoon Jung Park, Rainer Claus, Hamid Kashkar, Jens Seeger, Julia Claasen, Christian P. Pallasch, Christoph Plass, Michael Hallek, Clemens Wendtner, Lukas P. Frenzel
Journal: Blood (2012)
Association Between EZH2 and Other Acquired Mutations In Myelofibrosis and Myelodysplastic/Myeloproliferative Neoplasms
Authors: Thomas Ernst, Joannah Score, Claire E Hidalgo-Curtis, Amy V Jones, Andreas Hochhaus, Dolors Colomer, Francisco Cervantes, Andrew J Chase, Nicholas C.P. Cross
Journal: Blood (2010)
Germline Mutations within the IL2-Inducible T Cell Kinase Impede T Cell Differentiation or Survival, Cause Protein Destabilisation, Loss of Membrane Recruitment and Lead to Severe EBV Lymphoproliferation
Authors: Rene Martin Linka, Kirsten Huck, Frank Krux, Polina Stepenski, Cindy Synaeve, Kim Vettenranta, Rene Deenen, Ingrid Müller-Fleckenstein, Yvonne Linka, Sebastian Ginzel, Anne Halenius, Karl Köhrer, Bernhard Fleckenstein, Hans Jürgen Laws, Roland Hartig, Burkhart Schraven, Sylvain Latour, Arndt Borkhardt
Journal: Blood (2010)
Successful removal of a trapped pancreatic plastic stent using extracorporeal shock wave lithotripsy
Authors: Hao Wu, Lei Wang, Hui Chen, Xiao Liu, Zhao-Shen Li, Zhuan Liao
Journal: Endoscopy (2019)

An 18-year-old woman was admitted to our department because of a 4-year history of intermittent upper abdominal pain. Previously she had been diagnosed with chronic pancreatitis and had undergone several sessions of extracorporeal shock wave lithotripsy (ESWL) and endoscopic retrograde cholangiopancreatography (ERCP). An 8.5-Fr plastic stent 5 cm in length (Boston Scientific, Marlborough, Massachusetts, USA) was placed in the pancreatic duct 11 months prior to admission at our department.
Front-Line Consolidation with Autologous Stem Cell Transplantation in Patients with Nodal Aggressive Peripheral T-Cell Lymphoma (PTCL). A Prospective Study of the GEL-TAMO.
Authors: Jose Rodriguez, Eulogio Conde, Antonio Gutierrez, Reyes Arranz, Angel Leon, Julian Marin, Maurizio Bendandi, Carmen Albo, Maria Dolores Caballero
Journal: Blood (2006)
Bruton′s Tyrosine Kinase Inhibitor Ibrutinib Interferes With Constitutive and Induced Pre-B Cell Receptor Signaling In B-Cell Acute Lymphoblastic Leukemia
Authors: Ekaterina Kim, Stefan Koehrer, Nathalie Y. Rosin, Zhiqiang Wang, Deborah A. Thomas, Farhad Ravandi, Steven M. Kornblau, Hagop M. Kantarjian, Susan O'Brien, Zeev Estrov, Joseph J. Buggy, Markus Muschen, Richard E. Davis, Jan A. Burger
Journal: Blood (2013)
Proteasome Inhibitors Block Myeloma-Induced Osteocyte Death in Vitro and in Vivo in Multiple Myeloma Patients
Authors: Denise Toscani, Benedetta Dalla Palma, Carla Palumbo, Marzia Ferretti, Marina Bolzoni, Daniela Guasco, Cristina Mancini, Eugenia Martella, Mirca Lazzaretti, Mario Pedrazzoni, Franco Aversa, Nicola Giuliani
Journal: Blood (2012)
Endothelial Microparticles, Platelet and Leukocyte Activation and Cellular Interactions in Patients with Non-Valvular Atrial Fibrillation.
Authors: Julio A. Chirinos, Aurelio Castrellon, Wenche Jy, Lawrence L. Horstmann, Joaquin J. Jimenez, Howard J. Willens, Agustin Castellanos, Robert J. Myerburg, Yeon S. Ahn
Journal: Blood (2005)
Clinical Outcomes of 2-Step Approach to Haploidentical Hematopoietic Stem Cell Transplantation (HSCT): Effects of CD34 Stem Cell Dose in the Setting of a Consistent T-Cell Dose
Authors: Sameh Gaballa, Neil D. Palmisiano, Onder Alpdogan, Matthew Carabasi, Joanne Filicko-O'Hara, Margaret Kasner, Ubaldo Martinez, John L. Wagner, Mark Weiss, Neal Flomenberg, Dolores Grosso
Journal: Blood (2014)
Inhibition of PRMT1 Mediated FLT3 Arginine Methylation As a Potent Therapeutic Strategy for MLL-r ALL
Authors: Yinghui Zhu, Xin He, Haojie Dong, Jie Sun, Hanying Wang, Lei Zhang, Yunan Miao, Jian Jin, Yudao Shen, Jianjun Chen, Markus Muschen, Chun-Wei Chen, Marina Y. Konopleva, Weili Sun, Bin Zhang, Ya-Huei Kuo, Nadia Carlesso, Guido Marcucci, Ling Li
Journal: Blood (2018)
MiRNA Expression Signatures in Acute Myeloid Leukemia Are Predictors for Patient Outcome.
Authors: Thomas Illmer, David Kosel, Markus A. Schaich, Christian Thiede, Andreas Neubauer, Carsten Mueller-Tidow, Martin Bornhaeuser, Alex Kiani, Gerhard Ehninger, David Brown, Dimitriy Ovcharenko
Journal: Blood (2006)
Loss of Normal T-Cell Subset Distribution in Myelofibrosis Is Recovered By the Immunomodulatory Effects of JAK1/2 Inhibition
Authors: Sanja Prijic, Taghi Manshouri, Ivo Veletic, Kate J Newberry, Ying Zhang, Joseph E Bove, Zeev Estrov, Srdan Verstovsek
Journal: Blood (2016)
Predictors Of Treatment Outcome With The Combination Of Carfilzomib, Lenalidomide, and Low-Dose Dexamethasone (CRd) In Newly Diagnosed Multiple Myeloma (NDMM)
Authors: Jagoda Jasielec, Dominik Dytfeld, Kent A. Griffith, Kathryn McDonnell, Daniel Lebovic, Malathi Kandarpa, David H. Vesole, Sundar Jagannath, Melissa A. Mietzel, Ravi Vij, Malek Faham, Liana Lee, Erik H. van Beers, Martin H. van Vliet, Joan Levy, Mattina Alonge, Shaun Rosebeck, Mark S. Kaminski, Andrzej J. Jakubowiak
Journal: Blood (2013)
Phase 3 Study of L-Glutamine Therapy in Sickle Cell Anemia and Sickle β0-Thalassemia Subgroup Analyses Show Consistent Clinical Improvement
Authors: Yutaka Niihara, Kusum Viswanathan, Scott T. Miller, Edouard Guillaume, Miren Blackwood, Rafael Razon, Lan Tran, Charles Stark
Journal: Blood (2016)
Heterogeneous Cellular Contributions to Elastic Laminae Formation in Arterial Wall Development
Authors: Chien-Jung Lin, Marius C. Staiculescu, Jie Z. Hawes, Austin J. Cocciolone, Bridget M. Hunkins, Robyn A. Roth, Chieh-Yu Lin, Robert P. Mecham, Jessica E. Wagenseil
Journal: Circulation Research (2019)

Elastin is an important ECM (extracellular matrix) protein in large and small arteries. Vascular smooth muscle cells (SMCs) produce the layered elastic laminae found in elastic arteries but synthesize little elastin in muscular arteries. However, muscular arteries have a well-defined internal elastic lamina (IEL) that separates endothelial cells (ECs) from SMCs. The extent to which ECs contribute elastin to the IEL is unknown.To use targeted elastin (Eln) deletion in mice to explore the relative contributions of SMCs and ECs to elastic laminae formation in different arteries.We used SMC- and EC-specific Cre recombinase transgenes with a novel floxed Eln allele to focus gene inactivation in mice. Inactivation of Eln in SMCs using Sm22aCre resulted in depletion of elastic laminae in the arterial wall with the exception of the IEL and SMC clusters in the outer media near the adventitia. Inactivation of elastin in ECs using Tie2Cre or Cdh5Cre resulted in normal medial elastin and a typical IEL in elastic arteries. In contrast, the IEL was absent or severely disrupted in muscular arteries. Interruptions in the IEL resulted in neointimal formation in the ascending aorta but not in muscular arteries.Combined with lineage-specific fate mapping systems, our knockout results document an unexpected heterogeneity in vascular cells that produce the elastic laminae. SMCs and ECs can independently form an IEL in most elastic arteries, whereas ECs are the major source of elastin for the IEL in muscular and resistance arteries. Neointimal formation at IEL disruptions in the ascending aorta confirms that the IEL is a critical physical barrier between SMCs and ECs in the large elastic arteries. Our studies provide new information about how SMCs and ECs contribute elastin to the arterial wall and how local elastic laminae defects may contribute to cardiovascular disease.
The Effect of Number of Metaphases Studied and Abnormal Metaphase Percentage On Cytogenetic Risk Stratification in Primary Myelofibrosis
Authors: Shaina A Rozell, Biruk Mengistu, Naseema Gangat, Curtis A. Hanson, Ryan A Knudson, Rhett P Ketterling, Animesh Pardanani, Ayalew Tefferi
Journal: Blood (2012)
Pretreatment Factors Associated with Second Malignancies Occuring After Frontline Fludarabine, Cyclophosphamide, and Rituximab (FCR) in Patients with Chronic Lymphocytic Leukemia (CLL).
Authors: Nicolas Batty, Xavier C. Badoux, Michael Keating, E. Lin, Susan Lerner, Susan O'Brien, Alessandra Ferrajoli, Tapan Kadia, Jan A. Burger, Stefan Faderl, William G. Wierda
Journal: Blood (2009)
Prospective Evaluation of 18-F FDG PET/CT and Biopsies of Osteolytic Lesions and Random Bone Marrow Samples in Newly Diagnosed Multiple Myeloma Patients
Authors: Sandra Sauer, Christos Sachpekidis, Simone Brandelik, Daniel Spira, Stefanie Huhn, Barbara Wagner, Manuela Hummel, Antonia Dimitrakopoulou-Strauss, Jennifer Mosebach, Stefan Delorme, Hartmut Goldschmidt, Carsten Müller-Tidow, Jens Hillengass
Journal: Blood (2018)
Temporal Trends in the Proportion Cured Among Patients Diagnosed with Acute Myeloid Leukemia in Sweden 1973-2001, a Population-Based Study.
Authors: Åsa Rangert Derolf, Therese M-L Andersson, Paul C Lambert, Sigurdur Y Kristinsson, Sandra Eloranta, Ola Landgren, Paul W Dickman, Magnus Bjorkholm
Journal: Blood (2009)
R-ACVBP Benefits to Younger Patients with Non-Germinal Centre Diffuse Large B-Cell Lymphoma As Compared to R-CHOP in the GELA Trial LNH03-2B
Authors: Thierry Jo Molina, Danielle Canioni, Christiane Copie-Bergman, Christian Recher, Marion Fournier, Corinne Haioun, Josette Briere, Francoise Berger, Christophe Fermé, Marie-Christine Copin, Rene-Olivier Casasnovas, Catherine Thieblemont, Karen Leroy, Gilles Andre Salles, Fabrice Jardin, Jean-Philippe Jais, Philippe Gaulard, Bertrand Coiffier, Herve Tilly
Journal: Blood (2011)
Safety, Efficacy and Pharmacokinetics of Nonacog Beta Pegol (N9-GP) in Prophylaxis and Treatment of Bleeding Episodes in Previously Treated Pediatric Hemophilia B Patients
Authors: Manuel Carcao, Marek Zak, Fara Abdul Karim, Hideji Hanabusa, Susan Kearney, Meng-Yao Lu, Paula Persson, Savita Rangarajan, Elena Santagostino
Journal: Blood (2014)
Time-Dependent Single-Molecule Interactions of the Platelet Integrin αIIbβ3 with Cyclic Arg-Gly-Asp and the Fibrin(ogen) γC-Dodecapeptide
Authors: Rustem I. Litvinov, Paul C. Billings, Craig N. Streu, John W. Weisel, Joel S. Bennett
Journal: Blood (2010)
Effect of definitive radiotherapy alone for the patients with esophageal squamous cell carcinoma
Authors: Ryo Morita, Ken Kato, Hiroshi Imazeki, Masahiko Aoki, Takahiro Miyamoto, Hirokazu Shoji, Yoshitaka Honma, Satoru Iwasa, Natsuko Okita, Takashima Atsuo, Mai Ego, Koji Inaba, Jun Itami, Narikazu Boku
Journal: Annals of Oncology (2019)
Heirarchical Clustering of Immunophenotypic Cell Surface Antigen Expression Identifies Clinically Meaningful Cohorts in Childhood AML: A Report from the Children's Oncology Group Protocol AAML0531
Authors: Michael R. Loken, Andrew P. Voigt, Robert B. Gerbing, Lisa Eidenschink Brodersen, Andrew J. Menssen, Laura Pardo, Alan S. Gamis, Todd A. Alonzo, Soheil Meshinchi
Journal: Blood (2015)
Therapeutic Infusion of Partially HLA-Matched Third-Party Virus-Specific T Cells in HSCT Patients with Refractory Viral Infection
Authors: Leighton Edward Clancy, Emily Blyth, Barbara Withers, Jane Burgess, Renee Simms, Chun Kei Kris Ma, Kenneth P. Micklethwaite, David Gottlieb
Journal: Blood (2014)
Real-World Effectiveness and Safety of Nivolumab in Special Subgroups of NSCLC pts: A Multicenter-Retrospective Study
Authors: Satoru Kitazono, Ryo Morita, Kyoichi Okishio, Junichi Shimizu, Haruhiro Saito, Hiroshi Sakai, Young Hak Kim, Osamu Hataji, Makiko Yomota, Keisuke Aoe, Osamu Kanai, Toru Kumagai, Kayoko Kibata, Hiroaki Tsukamoto, Satoshi Oizumi, Keisuke Tomii, Hiroshi Tanaka, Keiko Mizuno, Hirotoshi Hoshiyama, Kenya Ochi, Yuichiro Ohe
Journal: Annals of Oncology (2019)
Addition of Sorafenib to Chemotherapy Improves the Overall Survival of Older Adults with FLT3-ITD Mutated Acute Myeloid Leukemia (AML) (Alliance C11001)
Authors: Geoffrey L. Uy, Sumithra Mandrekar, Kristina Laumann, Ben Sanford, Guido Marcucci, Weiqiang Zhao, Mark J. Levis, Heidi D. Klepin, Maria R. Baer, Bayard L. Powell, Peter Westervelt, Daniel J. DeAngelo, Wendy Stock, Clara D. Bloomfield, John C. Byrd, Richard M. Stone, Richard A. Larson
Journal: Blood (2015)
Proteomic Evaluation of Pathways Associated with Dexamethasone-Induced Apoptosis and Resistance in Multiple Myeloma.
Authors: Karen S. Rees-Unwin, Rachel A. Craven, Sarah Hanrahan, Nicholas F. Totty, Ann M. Dring, Rosamonde E. Banks, Gareth J. Morgan, Faith E. Davies
Journal: Blood (2004)
Dysregulation of DNA Methylation Involves in Progression of Myeloid Leukemia in Down Syndrome
Authors: Satoshi Saida, Masahiro Nakamura, Tsutomu Toki, Yoko Nishinaka-Arai, Kiminori Terui, Kenichi Yoshida, Seishi Ogawa, Tatsutoshi Nakahata, Toshio Heike, Ken-ichiro Watanabe, Akira Watanabe, Etsuro Ito
Journal: Blood (2015)
Recombinant Human Soluble Thrombomodulin Enhances the Anti-Fibrinolytic and Anti-Leukemia Effects of All-Trans Retinoic Acid In Acute Promyelocytic Leukemia Cells.
Authors: Takayuki Ikezoe, Jing Yang, Chie Nishioka, Mayuka Isaka, Naomi Iwabu, Mizu Sakai, Ayuko Taniguchi, Kazuto Togitani, Goichi Honda, Akihito Yokoyama
Journal: Blood (2010)
17p Deletion in CLL: Detailed Analysis of TP53 Mutations, Alternative Mechanisms of p53 Inactivation, Clone Size and Clonal Evolution
Authors: Thorsten Zenz, Antonio Sarno, Sonja Häbe, Tina Denzel, Julia Mohr, Dominik Vollmer, Maria Heuberger, Dirk Winkler, Dirk Kienle, Andreas Bühler, Sim Truong, Nancy Patten, Michael Hallek, Hartmut Döhner, Stephan Stilgenbauer
Journal: Blood (2008)
A Multi-Center Phase I/II Study of Melphalan, Prednisone, Thalidomide and Defibrotide in Avanced Multiple Myeloma Patients.
Authors: Antonio Palumbo, Cecilia Rus, Davide Rossi, Patrizia Pregno, Maria Teresa Ambrosini, Ilaria Avonto, Francesca Gay, Federica Cavallo, Massimo Iacobelli, Gianluca Gaidano, Constantine Mitsiades, Paul G. Richardson, Kenneth C. Anderson, Mario Boccadoro
Journal: Blood (2006)
Analysis of Clinical Arterial and Metabolic Parameters in Chronic Phase CML Patients On Nilotinib in a Single Center Cohort
Authors: Hélène Labussière-Wallet, Yann Guillermin, Madeleine Etienne, Anne-Claire Barale, Caroline Serrier, Isabelle Tigaud, Sandrine Hayette, Oriane Le Borgne, Mohamad Sobh, Stephane Morisset, Fiorenza Barraco, Mauricette Michallet, Franck E. Nicolini
Journal: Blood (2012)
Metformin Abrogates Age-Associated Ovarian Fibrosis
Authors: Curtis W. McCloskey, David P. Cook, Brendan S. Kelly, Feryel Azzi, Christian H. Allen, Amanda Forsyth, Jeremy Upham, Katey J. Rayner, Douglas A. Gray, Robert W. Boyd, Sangeeta Murugkar, Bryan Lo, Dominique Trudel, Mary K. Senterman, Barbara C. Vanderhyden
Journal: Clinical Cancer Research (2019)

The ovarian cancer risk factors of age and ovulation are curious because ovarian cancer incidence increases in postmenopausal women, long after ovulations have ceased. To determine how age and ovulation underlie ovarian cancer risk, we assessed the effects of these risk factors on the ovarian microenvironment.Aged C57/lcrfa mice (0-33 months old) were generated to assess the aged ovarian microenvironment. To expand our findings into human aging, we assembled a cohort of normal human ovaries (n = 18, 21-71 years old). To validate our findings, an independent cohort of normal human ovaries was assembled (n = 9, 41-82 years old).We first validated the presence of age-associated murine ovarian fibrosis. Using interdisciplinary methodologies, we provide novel evidence that ovarian fibrosis also develops in human postmenopausal ovaries across two independent cohorts (n = 27). Fibrotic ovaries have an increased CD206+:CD68+ cell ratio, CD8+ T-cell infiltration, and profibrotic DPP4+αSMA+ fibroblasts. Metformin use was associated with attenuated CD8+ T-cell infiltration and reduced CD206+:CD68+ cell ratio.These data support a novel hypothesis that unifies the primary nonhereditary ovarian cancer risk factors through the development of ovarian fibrosis and the formation of a premetastatic niche, and suggests a potential use for metformin in ovarian cancer prophylaxis.See related commentary by Madariaga et al., p. 523.
Combination of the Histone Deacetylase Inhibitor Vorinostat and Dasatinib Increases Apoptosis in Bcr-abl+ Cells and Reverses Changes Associated with CML Progression.
Authors: Leo Kretzner, Anna Scuto, Agnes Juhasz, Richard Jove, Yun Yen, Stephen J. Forman, Mark Kirschbaum
Journal: Blood (2006)
Epic: A Phase 3 Trial of Ponatinib Compared with Imatinib in Patients with Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase (CP-CML)
Authors: Jeffrey H. Lipton, Charles Chuah, Agnes Guerci-Bresler, Gianantonio Rosti, David Simpson, Sarit Assouline, Gabriel Etienne, Franck E. Nicolini, Philipp Le Coutre, Richard Clark, Leif Stenke, David Andorsky, Vivian Oehler, Stephanie Lustgarten, Victor M. Rivera, Tim Clackson, Frank G Haluska, Michele Baccarani, Jorge E. Cortes, Francois Guilhot, Andreas Hochhaus, Timothy P. Hughes, Hagop M. Kantarjian, Neil P. Shah, Moshe Talpaz, Michael W. Deininger
Journal: Blood (2014)
Acupuncture Led Attenuation of Inflammatory and Nociceptive Peripheral and Central Microenvironment in Sickle Mice
Authors: Ying Wang, Jianxun Lei, Yann Y Lamarre, Ritu Jha, Fei Peng, Sarah Lam, Ellis Raduenz, Deniz Ercan-Fang, Kalpna Gupta
Journal: Blood (2015)
The Addition of Thalidomide to the Induction Treatment of Newly Presenting Myeloma Patients Increases the CR Rate Which Is Likely to Translate Into Improved PFS and OS.
Authors: Gareth J Morgan, Faith E Davies, Walter M Gregory, Susan E Bell, Alex J Szubert, Kim Cocks, Nuria Navarro Coy, Mark T Drayson, Roger G Owen, Fiona M Ross, Graham H Jackson, J. Anthony Child
Journal: Blood (2009)
Initial Treatment with Bortezomib (Velcade®), Doxil®, and Dexamethasone (VDD) Is Superior to Thalidomide and Dexamethasone (TD) as Initial Therapy Prior to Autologous Stem Cell Transplantation (ASCT) for Multiple Myeloma (MM)
Authors: Andrzej Jakubowiak, Tara Kendall, Ammar Al-Zoubi, Yasser Khaled, Shin Mineishi, Christine Brozo, Erica Campagnaro, Moshe Talpaz, Mark S. Kaminski
Journal: Blood (2008)
First-Line Treatment and Management of Chronic Myeloid Leukemia (CML) in Clinical Practice: Update of &gt; 1800 Patients (Pts) in the WORLD CML Registry
Authors: Jorge E. Cortes, Ricardo Pasquini, Hagop M. Kantarjian, David Joske, Luis A Meillon, Zhixiang Shen, Carmen Piccolo, Oleg Zernovak, Ramsathish Sivarathinasami, Dawn F. Eng, Dong-Wook Kim, Timothy P. Hughes
Journal: Blood (2012)
GNB1 K89M Drives TKI Resistance in ETV6-ABL1-Positive Leukemia
Authors: Olga Zimmermannova, Eliska Doktorova, Jan Stuchly, Meritxell Alberich Jorda, Jiri Petrak, JH Frederik Falkenburg, Julia Starkova, Jan Trka, Jan Zuna, Marketa Zaliova
Journal: Blood (2016)
Myeloid Leukemic Blasts Use the Endogenous HLA Class I Antigen Processing Machinery for Peptide Loading Onto HLA Class II Molecules: Implications for Immunotherapy.
Authors: Marvin M. van Luijn, Martine E.D. Chamuleau, Maaike E. Ressing, Emmanuel J.H.J. Wiertz, Suzanne Ostrand-Rosenberg, Yuri Souwer, Adri Zevenbergen, Gert J. Ossenkoppele, Arjan A. van de Loosdrecht, S. Marieke van Ham
Journal: Blood (2009)
Toll-like Receptors Gene Expression Is Modulated By Lysed Sickle Red Blood Cells
Authors: Thassila Nogueira Pitanga, Dalila Luciola Zanette, Caroline Conceição Guarda, Rayra Pereira Santiago, Sanzio Silva Santana, Vitor Valério Maffili, Junia Raquel Dutra Ferreira, Camylla Vilas Boas Figueiredo, Milena Magalhães Aleluia, Luciana Magalhaes Fiuza, Valma Maria Lopes, Ricardo Riccio Oliveira, Marilda Souza Goncalves
Journal: Blood (2016)
Prognostic value of ERCC1, thymidylate synthase and glutathione S-transferase π for 5-FU/oxaliplatin chemotherapy in advanced colorectal cancer
Authors: H. Kwon, M. S. Roh, S. Y. Oh, S. Kim, J. H. Lee, J. Kim, J. I. Park, K. J. Park, H. J. Choi, H. Kim
Journal: Journal of Clinical Oncology (2006)

3607 Background: The aim of this study was to determine whether expressions of the excision cross-complementing (ERCC1), thymidylate synthase (TS) and glutathione S-transferase π (GSTπ) predict clinical outcome in patients with advanced colorectal cancer treated with fluorouracil (5-FU)/oxaliplatin chemotherapy. Methods: The study population consisted of 70 advanced colorectal cancer patients (median age, 53 years). Patients were treated with oxaliplatin 85 mg/m 2 as a 2-hour infusion at days 1 plus LV 20 mg/m 2 over 10 minutes, followed by 5-FU bolus 400 mg/m 2 and 22 hour continuous infusion of 600 mg/m 2 at day 1–2. Treatment was repeated in 2 week intervals. The expressions of ERCC1, TS and GSTπ of primary tumors were examined by immunohistochemistry. Results: The positive rates of ERCC1, TS, and GSTπ were 55.7%, 68.6%, and 71.4%, respectively. The patients without TS expression were more likely to respond to chemotherapy (p=0.009). There were no significant differences between response and ERCC1 or GSTπ expression pattern (p=0.768, p=0.589, respectively). Median overall survival (OS) was significantly longer in patients without ERCC1 expression (p=0.0474). Patients with ERCC1 positive combined with TS positive, or those with ERCC1 positive combined with TS positive and GSTπ positive had poor OS (p=0.0017, p=0.0323, respectively). Multivariate analysis revealed that both ERCC1 and TS expression significantly impacted on OS (Hazard ratio 1.72, p=0.023). Conclusions: Immunohistochemical studies for ERCC1 and TS may be useful in prediction of the clinical outcome of advanced colorectal cancer patients treated with 5-FU and oxaliplatin. No significant financial relationships to disclose.
Mutations in the RAS Signaling, B-Cell Development, TP53/RB1, and JAK Signaling Pathways Are Common in High Risk B-Precursor Childhood Acute Lymphoblastic Leukemia (ALL): A Report From the Children's Oncology Group (COG) High-Risk (HR) ALL TARGET Project.
Authors: Jinghui Zhang, Charles G. Mullighan, Richard C. Harvey, Kenneth E Buetow, William L. Carroll, I-Ming Chen, Meenakshi Devidas, Michael Edmonson, Daniela Gerhard, Ying Hu, Mignon L. Loh, Letha A Phillips, Gregory H Reaman, Mary V. Relling, Malcolm Smith, James R. Downing, Cheryl L. Willman, Stephen P Hunger
Journal: Blood (2009)
Targeted Sequencing Reveals Novel Gene Mutations Associated with Transformation and Early Progression in Follicular Lymphoma
Authors: Robert Kridel, Fong Chun Chan, Anja Mottok, Merrill Boyle, Pedro Farinha, King Tan, Barbara Meissner, Ali Bashashati, Susana Ben-Neriah, Eva Gine, Daisuke Ennishi, Andrew J. Mungall, Ryan D. Morin, Nathalie A. Johnson, Laurie H. Sehn, Thomas Tousseyn, Ahmet Dogan, Joseph M. Connors, David W. Scott, Christian Steidl, Marco A. Marra, Randy D. Gascoyne, Sohrab P. Shah
Journal: Blood (2016)
Genomic Dissection of the Fcγ Receptor Region in the Context of Monoclonal Antibody Therapy
Authors: Chantal Hargreaves, Chisako Iriyama, Matthew JJ Rose-Zerilli, Charlotte Lee, Kathleen Potter, Rosalind Ganderton, Khiyam Hussain, Lee Machado, Edward Hollox, Sarah E Coupland, Michael Stackpole, Melanie Oates, Andrew R. Pettitt, Mark Cragg, Jonathan C Strefford
Journal: Blood (2014)
Predictors for Steroid Tapering in Patients with Acute Graft-Versus-Host Disease and Their Impact on Graft-Versus-Host Disease Response and Non-Relapse Mortality: Older Age and Co-Morbidities Are Associated with Quicker Tapering and Worse Outcomes
Authors: LaQuisa Hill, Rima M Saliba, Julianne Chen, Gabriela Rondon, Muzaffar H. Qazilbash, Uday R. Popat, Nina Shah, Joyce L Neumann, Sharon R Hymes, Chitra Hosing, Partow Kebriaei, Yago Nieto, Betul Oran, Amanda Olson, Stefan O. Ciurea, Katayoun Rezvani, David Marin, Richard E. Champlin, Elizabeth J. Shpall, Amin M. Alousi
Journal: Blood (2016)