tbuckley/cabot-search huggingface dataset:
Is the microbiome-induced glycolytic pathway a harbinger of acute exacerbation of idiopathic pulmonary fibrosis?
Authors: Ram P Naikawadi
Journal: Thorax (2020)

Idiopathic pulmonary fibrosis (IPF) is a chronic age-related disease with increasing prevalence that is characterised by progressive loss of lung function, which contributes to accelerated morbidity and mortality. While the exact aetiology is unknown, studies in patients with IPF and murine models of lung fibrosis have established genetic mutations1 2 and telomere dysfunction in alveolar epithelial cells3 as molecular drivers that lead to a series of events involving aberrant repair, fibroblast activation, senescence reprogramming, epithelial to mesenchymal transition and inflammatory cell recruitment to the fibrotic niche. After onset, disease progression is variable, with some patients suffering acute exacerbation. Although the cause of acute exacerbation remains unknown, they may be encountered in patients exposed to secondary insults, such as environmental pollutants like chitin polysaccharides,4 5 smoking and altered immune response.6 

To better understand the aetiology of acute exacerbation, several groups investigated the role of microbiome in IPF.7–10 Altered and increased bacterial burden is a common finding across all these studies. Molyneaux et al employed 16S bacterial ribosomal RNA sequencing to show there is increased bacterial burden in IPF lungs compared with control subjects and that patient survival was inversely correlated with bacterial burden.7 In the Correlating Outcomes with biochemical Markers to Estimate Time-progression in IPF (COMET-IPF) study, Han and colleagues found a significant association between relative abundance of Streptococcus and Staphylococcus with IPF disease progression.8 More recently, in a bleomycin model of lung fibrosis, O’Dwyer et al report that lung …
Polymeric modification of gemcitabine via cyclic acetal linkage for enhanced anticancer potency with negligible side effects
Authors: Hiroyasu Takemoto, Takanori Inaba, Takahiro Nomoto, Makoto Matsui, Xiaomeng Liu, Masahiro Toyoda, Yuto Honda, Kaori Taniwaki, Naoki Yamada, Junhyun Kim, Keishiro Tomoda, Nobuhiro Nishiyama
Journal: Biomaterials (2020)
Steroid resistance in Diamond Blackfan anemia associates with p57Kip2 dysregulation in erythroid progenitors
Authors: Ryan J. Ashley, Hongxia Yan, Nan Wang, John Hale, Brian M. Dulmovits, Julien Papoin, Meagan E. Olive, Namrata D. Udeshi, Steven A. Carr, Adrianna Vlachos, Jeffrey M. Lipton, Lydie Da Costa, Christopher Hillyer, Sandrina Kinet, Naomi Taylor, Narla Mohandas, Anupama Narla, Lionel Blanc
Journal: Journal of Clinical Investigation (2020)

Despite the effective clinical use of steroids for the treatment of Diamond Blackfan anemia (DBA), the mechanisms through which glucocorticoids regulate human erythropoiesis remain poorly understood. We report that the sensitivity of erythroid differentiation to dexamethasone is dependent on the developmental origin of human CD34+ progenitor cells, specifically increasing the expansion of CD34+ progenitors from peripheral blood (PB) but not cord blood (CB). Dexamethasone treatment of erythroid-differentiated PB, but not CB, CD34+ progenitors resulted in the expansion of a newly defined CD34+CD36+CD71hiCD105med immature colony-forming unit–erythroid (CFU-E) population. Furthermore, proteomics analyses revealed the induction of distinct proteins in dexamethasone-treated PB and CB erythroid progenitors. Dexamethasone treatment of PB progenitors resulted in the specific upregulation of p57Kip2, a Cip/Kip cyclin–dependent kinase inhibitor, and we identified this induction as critical; shRNA-mediated downregulation of p57Kip2, but not the related p27Kip1, significantly attenuated the impact of dexamethasone on erythroid differentiation and inhibited the expansion of the immature CFU-E subset. Notably, in the context of DBA, we found that steroid resistance was associated with dysregulated p57Kip2 expression. Altogether, these data identify a unique glucocorticoid-responsive human erythroid progenitor and provide new insights into glucocorticoid-based therapeutic strategies for the treatment of patients with DBA.
Intelligently thermoresponsive flower-like hollow nano-ruthenium system for sustained release of nerve growth factor to inhibit hyperphosphorylation of tau and neuronal damage for the treatment of Alzheimer's disease
Authors: Hui Zhou, Youcong Gong, Yanan Liu, Anlian Huang, Xufeng Zhu, Jiawei Liu, Guanglong Yuan, Li Zhang, Ji-an Wei, Jie Liu
Journal: Biomaterials (2020)
内分泌・代謝疾患:ニコチンアミドヌクレオチドトランスヒドロゲナーゼをコードするNNTの変異は家族性グルココルチコイド欠損症を引き起こす | 文献情報 | J-GLOBAL 科学技術総合リンクセンター
Authors: Meimaridou Eirini, Kowalczyk Julia, Guasti Leonardo, Hughes Claire R, Chapple J Paul, King Peter J, Clark Adrian J L, Metherell Louise A, Wagner Florian, Nuernberg Peter, Frommolt Peter, Mann Nicholas P, Banerjee Ritwik, Saka H Nurcin
Journal: Nature Genetics (2012)
Human adipose stem cell-derived extracellular nanovesicles for treatment of chronic liver fibrosis
Authors: Hwa Seung Han, Hansang Lee, DongGil You, Van Quy Nguyen, Dae-Geun Song, Byeong Hoon Oh, Sol Shin, Ji Suk Choi, Jae Dong Kim, Cheol-Ho Pan, Dong-Gyu Jo, Yong Woo Cho, Ki Young Choi, Jae Hyung Park
Journal: Journal of Controlled Release (2020)
Psychological interventions for common mental disorders in women experiencing intimate partner violence in low-income and middle-income countries: a systematic review and meta-analysis
Authors: Roxanne C Keynejad, Charlotte Hanlon, Louise M Howard
Journal: The Lancet Psychiatry (2020)

Evidence on the effectiveness of psychological interventions for women with common mental disorders (CMDs) who also experience intimate partner violence is scarce. We aimed to test our hypothesis that exposure to intimate partner violence would reduce intervention effectiveness for CMDs in low-income and middle-income countries (LMICs).
Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries
Authors: Tarini Shankar Ghosh, Simone Rampelli, Ian B Jeffery, Aurelia Santoro, Marta Neto, Miriam Capri, Enrico Giampieri, Amy Jennings, Marco Candela, Silvia Turroni, Erwin G Zoetendal, Gerben D A Hermes, Caumon Elodie, Nathalie Meunier, Corinne Malpuech Brugere, Estelle Pujos-Guillot, Agnes M Berendsen, Lisette C P G M De Groot, Edith J M Feskins, Joanna Kaluza, Barbara Pietruszka, Marta Jeruszka Bielak, Blandine Comte, Monica Maijo-Ferre, Claudio Nicoletti, Willem M De Vos, Susan Fairweather-Tait, Aedin Cassidy, Patrizia Brigidi, Claudio Franceschi, Paul W O'Toole
Journal: Gut (2020)

Objective Ageing is accompanied by deterioration of multiple bodily functions and inflammation, which collectively contribute to frailty. We and others have shown that frailty co-varies with alterations in the gut microbiota in a manner accelerated by consumption of a restricted diversity diet. The Mediterranean diet (MedDiet) is associated with health. In the NU-AGE project, we investigated if a 1-year MedDiet intervention could alter the gut microbiota and reduce frailty. Design We profiled the gut microbiota in 612 non-frail or pre-frail subjects across five European countries (UK, France, Netherlands, Italy and Poland) before and after the administration of a 12-month long MedDiet intervention tailored to elderly subjects (NU-AGE diet). Results Adherence to the diet was associated with specific microbiome alterations. Taxa enriched by adherence to the diet were positively associated with several markers of lower frailty and improved cognitive function, and negatively associated with inflammatory markers including C-reactive protein and interleukin-17. Analysis of the inferred microbial metabolite profiles indicated that the diet-modulated microbiome change was associated with an increase in short/branch chained fatty acid production and lower production of secondary bile acids, p-cresols, ethanol and carbon dioxide. Microbiome ecosystem network analysis showed that the bacterial taxa that responded positively to the MedDiet intervention occupy keystone interaction positions, whereas frailty-associated taxa are peripheral in the networks. Conclusion Collectively, our findings support the feasibility of improving the habitual diet to modulate the gut microbiota which in turn has the potential to promote healthier ageing.
Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips
Authors: Anna Herland, Ben M. Maoz, Debarun Das, Mahadevabharath R. Somayaji, Rachelle Prantil-Baun, Richard Novak, Michael Cronce, Tessa Huffstater, Sauveur S. F. Jeanty, Miles Ingram, Angeliki Chalkiadaki, David Benson Chou, Susan Marquez, Aaron Delahanty, Sasan Jalili-Firoozinezhad, Yuka Milton, Alexandra Sontheimer-Phelps, Ben Swenor, Oren Levy, Kevin K. Parker, Andrzej Przekwas, Donald E. Ingber
Journal: Nature Biomedical Engineering (2020)
Associations between historical residential redlining and current age-adjusted rates of emergency department visits due to asthma across eight cities in California: an ecological study
Authors: Anthony Nardone, Joan A Casey, Rachel Morello-Frosch, Mahasin Mujahid, John R Balmes, Neeta Thakur
Journal: The Lancet Planetary Health (2020)

Asthma disproportionately affects communities of colour in the USA, but the underlying factors for this remain poorly understood. In this study, we assess the role of historical redlining as outlined in security maps created by the Home Owners' Loan Corporation (HOLC), the discriminatory practice of categorising neighbourhoods on the basis of perceived mortgage investment risk, on the burden of asthma in these neighbourhoods.We did an ecological study of HOLC risk grades and asthma exacerbations in California using the security maps available for the following eight cities: Fresno, Los Angeles, Oakland, Sacramento, San Diego, San Jose, San Francisco, and Stockton. Each census tract was categorised into one of four risk levels (A, B, C, or D) on the basis of the location of population-weighted centroids on security maps, with the worst risk level (D) indicating historical redlining. We obtained census tract-level rates of emergency department visits due to asthma from CalEnviroScreen 3.0. We assessed the relationship between risk grade and log-transformed asthma visit rates between 2011 and 2013 using ordinary least squares regression. We included potential confounding variables from the 2010 Census and CalEnviroScreen 3.0: diesel exhaust particle emissions, PM2·5, and percent of the population living below 2 times the federal poverty level. We also built random intercept and slope models to assess city-level variation in the relationship between redlining and asthma.In the 1431 census tracts assessed (64 [4·5%] grade A, 241 [16·8%] grade B, 719 [50·2%] grade C, and 407 [28·4%] grade D), the proportion of the population that was non-Hispanic black and Hispanic, the percentage of the population living in poverty, and diesel exhaust particle emissions all significantly increased as security map risk grade worsened (p<0·0001). The median age-adjusted rates of emergency department visits due to asthma were 2·4 times higher in census tracts that were previously redlined (median 63·5 [IQR 34·3] visits per 10 000 residents per year [2011-13]) than in tracts at the lowest risk level (26·5 [18·4]). In adjusted models, redlined census tracts were associated with a relative risk of 1·39 (95% CI 1·21-1·57) in rates of emergency department visits due to asthma compared with that of lowest-risk census tracts.Historically redlined census tracts have significantly higher rates of emergency department visits due to asthma, suggesting that this discriminatory practice might be contributing to racial and ethnic asthma health disparities.National Heart Lung Blood Institute.
Price Transparency in the Electronic Health Record—Reply
Authors: Brian J. Miller, Jennifer M. Slota, Jesse M. Ehrenfeld
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Suicide Rates by Industry and Occupation — National Violent Death Reporting System, 32 States, 2016
Authors: Cora Peterson, Aaron Sussell, Jia Li, Pamela K. Schumacher, Kristin Yeoman, Deborah M. Stone
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

In 2017, nearly 38,000 persons of working age (16-64 years) in the United States died by suicide, which represents a 40% rate increase (12.9 per 100,000 population in 2000 to 18.0 in 2017) in less than 2 decades.* To inform suicide prevention, CDC analyzed suicide data by industry and occupation among working-age decedents presumed to be employed at the time of death from the 32 states participating in the 2016 National Violent Death Reporting System (NVDRS).†,§ Compared with rates in the total study population, suicide rates were significantly higher in five major industry groups: 1) Mining, Quarrying, and Oil and Gas Extraction (males); 2) Construction (males); 3) Other Services (e.g., automotive repair) (males); 4) Agriculture, Forestry, Fishing, and Hunting (males); and 5) Transportation and Warehousing (males and females). Rates were also significantly higher in six major occupational groups: 1) Construction and Extraction (males and females); 2) Installation, Maintenance, and Repair (males); 3) Arts, Design, Entertainment, Sports, and Media (males); 4) Transportation and Material Moving (males and females); 5) Protective Service (females); and 6) Healthcare Support (females). Rates for detailed occupational groups (e.g., Electricians or Carpenters within the Construction and Extraction major group) are presented and provide insight into the differences in suicide rates within major occupational groups. CDC's Preventing Suicide: A Technical Package of Policy, Programs, and Practices (1) contains strategies to prevent suicide and is a resource for communities, including workplace settings.
Pediatric Implications of Opioid-Specific Parental Drug Use—Reply
Authors: Angélica Meinhofer
Journal: JAMA Pediatrics (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Eva1a ameliorates atherosclerosis by promoting re-endothelialization of injured arteries via Rac1/Cdc42/Arpc1b
Authors: Jingxuan Li, Yingyu Chen, Jianing Gao, Yue Chen, Changping Zhou, Xin Lin, Changjie Liu, Mingming Zhao, Yangkai Xu, Liang Ji, Zongzhe Jiang, Bing Pan, Lemin Zheng
Journal: Cardiovascular Research (2020)

Abstract Aims Eva-1 homologue 1 (Eva1a) is a novel protein involved in the regulation of cardiac remodelling and plaque stability, but little is known about its role in re-endothelialization and the development of atherosclerosis (AS). Thus, in the present study, we aimed to elucidate the function of Eva1a in re-endothelialization and AS. Methods and results Wire injuries of carotid and femoral arteries were established in Eva1a−/− mice. Eva1a-deficient mice were crossed with apolipoprotein E−/− (ApoE−/−) mice to evaluate AS development and re-endothelialization of carotid artery injuries. Denudation of the carotid artery at 3, 5, and 7 days was significantly aggravated in Eva1a−/− mice. The neointima of the femoral artery at 14 and 28 days was consequently exacerbated in Eva1a−/− mice. The area of atherosclerotic lesions was increased in Eva1a−/−ApoE−/− mice. To explore the underlying mechanisms, we performed transwell, scratch migration, cell counting kit-8, and bromodeoxyuridine assays using cultured human aorta endothelial cells (HAECs), which demonstrated that EVA1A promoted HAEC migration and proliferation. Proteomics revealed that the level of actin-related protein 2/3 complex subunit 1B (Arpc1b) was decreased, while Eva1a expression was absent. Arpc1b was found to be a downstream molecule of EVA1A by small interfering RNA transfection assay. Activation of Rac1 and Cdc42 GTPases was also regulated by EVA1A. Conclusion This study provides insights into anti-atherogenesis effects of Eva1a by promoting endothelium repair. Thus, Eva1a is a promising therapeutic target for AS.
Virulence gene repression promotes <i>Listeria monocytogenes</i> systemic infection
Authors: Rita Pombinho, Ana Vieira, Ana Camejo, Cristel Archambaud, Pascale Cossart, Sandra Sousa, Didier Cabanes
Journal: Gut Microbes (2020)

The capacity of bacterial pathogens to infect their hosts depends on the tight spatiotemporal regulation of virulence genes. The Listeria monocytogenes (Lm) metal efflux pump repressor CadC is highly expressed during late infection stages, modulating lipoprotein processing and host immune response. Here we investigate the potential of CadC as broad repressor of virulence genes. We show that CadC represses the expression of the bile salt hydrolase impairing Lm resistance to bile. During late infection, in absence of CadC-dependent repression, the constitutive bile salt hydrolase expression induces the overexpression of the cholic acid efflux pump MdrT that is unfavorable to Lm virulence. We establish the CadC regulon and show that CadC represses additional virulence factors activated by σB during colonization of the intestinal lumen. CadC is thus a general repressor that promotes Lm virulence by down-regulating, at late infection stages, genes required for survival in the gastrointestinal tract. This demonstrates for the first time how bacterial pathogens can repurpose regulators to spatiotemporally repress virulence genes and optimize their infectious capacity.
B01 Active YAP as a Functional Marker of Drug-Tolerant Persister Cells in EGFR-Mutant and ALK Fusion-Positive NSCLC
Authors: F. Haderk, C. Fernández-Méndez, K.N. Shah, W. Wu, J. Guan, J. Rotow, D. Allegakoen, V. Olivas, S. Bandyopadhyay, C. Kuo, T. Bivona
Journal: Journal of Thoracic Oncology (2020)
Carpal tunnel syndrome in cardiac amyloidosis: implications for early diagnosis and prognostic role across the spectrum of aetiologies
Authors: Agnese Milandri, Andrea Farioli, Christian Gagliardi, Simone Longhi, Fabrizio Salvi, Stefania Curti, Serena Foffi, Angelo Giuseppe Caponetti, Massimiliano Lorenzini, Alessandra Ferlini, Paola Rimessi, Stefano Mattioli, Francesco Saverio Violante, Claudio Rapezzi
Journal: European Journal of Heart Failure (2020)

Abstract Aims We aimed to assess carpal tunnel syndrome (CTS) prevalence in transthyretin (TTR)‐related and light‐chain amyloidosis (AL), comparing it to the general population, adjusted for age and gender. In TTR‐related amyloidosis (ATTR) we investigated (i) CTS prevalence in relation to genotype, cardiac amyloidosis (CA), age and gender; (ii) CTS role as an incremental risk factor for CA; (iii) temporal relationship between CTS and CA; and (iv) CTS prognostic role. Methods and results Data from 538 subjects (166 hereditary ATTR, 107 wild‐type ATTR, 196 AL amyloidosis, and 69 TTR mutation carriers; 64% male, median age 62.4 years), evaluated at our centre (Bologna, Italy), were analysed and compared to a published cohort of 14.9 million people, in which incidence rates of CTS had been estimated. CTS prevalence was highest in ATTR patients with CA (20.3% vs. 4.1% in the general population), while it was comparable to the general population when CA was absent and in AL patients. CTS standardized incidence rates were markedly elevated in ATTR males in the eighth decade of life (13.08 in hereditary ATTR, 15.5 in wild‐type ATTR). The risk of developing CA was greater in ATTR patients with CTS; the probability of having CTS was highest 5–9 years prior to CA diagnosis. CTS was an independent mortality risk factor in ATTR. Conclusions Compared to general population the adjusted prevalence of CTS is higher among elderly men with ATTR; CTS is a prognostic marker in ATTR, independently of cardiac involvement, and precedes CA diagnosis by 5–9 years. The awareness of this association and time delay offers the possibility of an early pre‐clinical ATTR‐CA diagnosis.
Changing Pediatric Primary Care
Authors: James M. Perrin, Nicolas M. Oreskovic
Journal: JAMA Pediatrics (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal