tbuckley/cabot-search huggingface dataset:
miR-27a regulates vascular remodeling by targeting endothelial cells' apoptosis and interaction with vascular smooth muscle cells in aortic dissection
Authors: Yudong Sun, Yu Xiao, Huiying Sun, Zhiqing Zhao, Jiang Zhu, Lei Zhang, Jian Dong, Tonglei Han, Qing Jing, Jian Zhou, Zaiping Jing
Journal: Theranostics (2019)

Rationale: Aortic dissection (AD) is caused by functional disorder of cells in the aortic wall, which is largely attributed to vascular remodeling.Therapeutic strategies for AD remain limited due to our incomplete understanding of the role of endothelial cells (ECs) in AD pathogenesis.This study aimed to identify the regulatory role of miR-27a in AD and provide a mechanistic basis for a non-invasive treatment of AD.Methods: We harvested aortas from normal and AD patients to explore the expression of miR-27a.In vitro and in vivo assays were preformed to explore the biological effects of differential expression of miR-27a in ECs and its regulatory effect on AD.Results: MiR-27a was lower in intima of AD samples than in healthy individuals.Downregulation of miR-27a in EC was due to up-regulated expression of fas-associated protein with death domain (FADD) and the activation of apoptosis pathway, which led to apoptosis of ECs.Migration of vascular smooth muscle cells was promoted by EC after downregulation of miR-27a due to enhancement of growth/differentiation factor 8 (GDF8) and repression of matrix metalloproteinase-20 (MMP20) in the co-culture system supernatants.Increase in FADD and apoptosis of ECs to induce AD was shown using mouse models of AD in which miR-27a was stably knocked-down by antagomir.Up-regulation of miR-27a by agomir led to a protective effect on AD.Conclusion: Treatment with miR-27a activator that targets apoptosis of ECs strongly diminished occurrence of AD, providing a new strategy for this disease.
Risk of Nephrogenic Systemic Fibrosis in Patients With Stage 4 or 5 Chronic Kidney Disease Receiving a Group II Gadolinium-Based Contrast Agent
Authors: Sean A. Woolen, Prasad R. Shankar, Joel J. Gagnier, Mark P. MacEachern, Lisa Singer, Matthew S. Davenport
Journal: JAMA Internal Medicine (2019)

<h3>Importance</h3> Risk of nephrogenic systemic fibrosis (NSF) to individual patients with stage 4 or 5 chronic kidney disease (CKD; defined as estimated glomerular filtration rate of &lt;30 mL/min/1.73 m<sup>2</sup>) who receive a group II gadolinium-based contrast agent (GBCA) is not well understood or summarized in the literature. <h3>Objective</h3> To assess the pooled risk of NSF in patients with stage 4 or 5 CKD receiving a group II GBCA. <h3>Data Sources</h3> A health sciences informationist searched the Ovid (MEDLINE and MEDLINE Epub Ahead of Print, In-Process &amp; Other Non-Indexed Citation, and Daily and Versions), Embase, Cochrane Central Register of Controlled Trials, Web of Science, and Open Grey databases from inception to January 29, 2019, yielding 2700 citations. <h3>Study Selection</h3> Citations were screened for inclusion in a multistep process. Agreement for final cohort inclusion was determined by 2 blinded screeners using Cohen κ. Inclusion criteria consisted of stage 4 or 5 CKD with or without dialysis, administration of an unconfounded American College of Radiology classification group II GBCA (gadobenate dimeglumine, gadobutrol, gadoterate meglumine, or gadoteridol), and incident NSF as an outcome. Conference abstracts, retracted manuscripts, narrative reviews, editorials, case reports, and manuscripts not reporting total group II GBCA administrations were excluded. <h3>Data Extraction and Synthesis</h3> Data extraction was performed for all studies by a single investigator, including publication details, study design and time frame, patient characteristics, group II GBCA(s) administered, total exposures for patients with stage 4 or stage 5 CKD, total cases of unconfounded NSF, reason for GBCA administration, follow-up duration, loss to follow-up, basis for NSF screening, and diagnosis. <h3>Main Outcomes and Measures</h3> Pooled incidence of NSF and the associated upper bound of a 2-sided 95% CI (risk estimate) for the pooled data and each of the 4 group II GBCAs. <h3>Results</h3> Sixteen unique studies with 4931 patients were included (κ = 0.68) in this systematic review and meta-analysis. The pooled incidence of NSF was 0 of 4931 (0%; upper bound of 95% CI, 0.07%). The upper bound varied owing to different sample sizes for gadobenate dimeglumine (0 of 3167; upper bound of 95% CI, 0.12%), gadoterate meglumine (0 of 1204; upper bound of 95% CI, 0.31%), gadobutrol (0 of 330; upper bound of 95% CI, 1.11%), and gadoteridol (0 of 230; upper bound of 95% CI, 1.59%). <h3>Conclusions and Relevance</h3> This study's findings suggest that the risk of NSF from group II GBCA administration in stage 4 or 5 CKD is likely less than 0.07%. The potential diagnostic harms of withholding group II GBCA for indicated examinations may outweigh the risk of NSF in this population. <h3>Trial Registration</h3> PROSPERO identifier:CRD42019123284
The Effect of Dietary Copper on Rat Carcinogenesis by 3-Methoxy Dyes
Authors: G. Fare, J. S. Howell
Journal: Cancer Research (1964)

Summary  Ten rats painted twice weekly with 1 ml of 0.2% 3-methoxy-4-dimethylaminoazobenzene in acetone all developed multiple skin tumors irrespective of whether they were fed maize containing 0.5% cupric oxyacetate hexahydrate or maize alone. The average induction time was 46 weeks, but during the following 16 weeks large numbers of lesions occurred. these were usually keratinous and covered up to 5 sq cm of skin. All lesions were found within the painted area on the dorsal skin, and the histologic types of tumor were the same as have been found in rats treated with other carcinogens: squamous carcinoma, keratoacanthoma, and basal cell carcinoma sometimes with sebaceous or trichoepitheliomatous differentiation. Apart from 3 ear duct tumors, no lesions at other sites were detected.
Pathways to independence: towards producing and using trustworthy evidence
Authors: Ray Moynihan, Lisa Bero, Sue Hill, Minna Johansson, Joel Lexchin, Helen Macdonald, Barbara Mintzes, Cynthia Pearson, Marc A Rodwin, Anna Stavdal, Jacob Stegenga, Brett D Thombs, Hazel Thornton, Per Olav Vandvik, Beate Wieseler, Fiona Godlee
Journal: BMJ (2019)

We all want to make healthcare decisions based on trustworthy evidence.Yet the landmark 2009 Institute of Medicine report identified widespread financial conflicts of interest across medical research, education, and practice.(1) It highlighted that extensive industry influence may be jeopardizing "the integrity of scientific investigations, the objectivity of medical education, the quality of patient care, and the public's trust in medicine."(1) At the same time there's increasing appreciation across nations and within clinical and scientific communities of the problem of too much medicine.(2-5) Overtesting, overdiagnosis and overtreatment divert resources from https://www.nhmrc.gov.au/guidelinesforguidelines/plan/identifying-and-managingconflicts-interest
Abstract 16460: Serotonin Influences Inflammatory Cell Recruitment During Myocardial Ischemia-Reperfusion Injury in Mice
Authors: Maximilian Mauler, Christoph Koentges, Alexander Maier, Thilo Witsch, Daniela Stallmann, Christoph Bode, Heiko Bugger, Daniel Duerschmied
Journal: Circulation (2013)

Introduction: Cardiac tissue serotonin levels are increased in myocardial infarction. The role of serotonin in ischemia-reperfusion (I/R) injury however is not well understood. Tryptophan hydroxyla...
Gabapentinoid treatment promotes corticospinal plasticity and regeneration following murine spinal cord injury
Authors: Wenjing Sun, Molly Je Larson, Conrad M Kiyoshi, Alexander J Annett, William A Stalker, Juan Peng, Andrea Tedeschi
Journal: Journal of Clinical Investigation (2019)

Axon regeneration failure causes neurological deficits and long-term disability after spinal cord injury (SCI). Here, we found that the α2δ2 subunit of voltage-gated calcium channels negatively regulates axon growth and regeneration of corticospinal neurons, the cells that originate the corticospinal tract. Increased α2δ2 expression in corticospinal neurons contributed to loss of corticospinal regrowth ability during postnatal development and after SCI. In contrast, α2δ2 pharmacological blockade through gabapentin administration promoted corticospinal structural plasticity and regeneration in adulthood. Using an optogenetic strategy combined with in vivo electrophysiological recording, we demonstrated that regenerating corticospinal axons functionally integrate into spinal circuits. Mice administered gabapentin recovered upper extremity function after cervical SCI. Importantly, such recovery relies on reorganization of the corticospinal pathway, as chemogenetic silencing of injured corticospinal neurons transiently abrogated recovery. Thus, targeting α2δ2 with a clinically relevant treatment strategy aids repair of motor circuits after SCI.
THE VALUE OF IMMUNOFLUORESCENCE IN THE STUDY OF HUMAN RENAL DISEASE
Authors: Robert T. McCluskey
Journal: The Journal of Experimental Medicine (1971)

Immunofluorescence is a useful technique in the study of human renal diseases, both from the point of view of elucidating pathogenic mechanisms and as a diagnostic tool. The finding of characteristic staining patterns for immunoglobulins and complement indicates that many forms of glomerulonephritis are immune complex diseases and that a few are due to anti-GBM antibodies. On the other hand, in lipoid nephrosis and toxemia of pregnancy, deposits of immunoglobulins and complement are generally absent, indicating that immunologic mechanisms are probably not responsible for these glomerular diseases. The finding of fibrin or other fibrinogen derivatives in glomeruli in toxemia of pregnancy and in certain forms of glomulonephritis supports the interpretation that these substances play a pathogenic role in certain glomerular diseases. The use of immunofluorescence has led to the recognition of two previously unrecognized renal diseases: nephropathy with mesangial IgA-IgG deposits (Berger), and a tubular disorder with deposits of immunoglobulins and complement along the basement membrane.
Retinal Hemorrhage from Blunt Ocular Trauma
Authors: Jitender Jinagal, Poonam Dhiman
Journal: New England Journal of Medicine (2019)

A 24-year-old man presented to the emergency department with pain, swelling, and decreased vision in his right eye 6 hours after it had been directly struck by a tennis ball. Physical examination of the right eye showed a visual acuity of 20/400, with an intraocular pressure of 20 mm Hg (reference range, 10 to 21) and a sluggish pupillary response to light. The left eye appeared normal, with a visual acuity of 20/20 and an intraocular pressure of 18 mm Hg. Slit-lamp examination of the right eye showed edema of the eyelid, conjunctival congestion, and a normal anterior chamber, cornea, and lens. On examination of the fundus, however, the foveal reflex was absent owing to the presence of a retinal hemorrhage at the macula (arrowhead) that measured approximately 5 disk diameters. A D-shaped subhyaloid hemorrhage (arrow) was also seen below the fovea and above the inferior arcade. A pars plana vitrectomy with internal tamponade was performed. At the 8-week follow-up visit, the patient’s visual acuity in the right eye had improved to 20/30, and examination of the fundus showed resolution of the retinal hemorrhage and a normal foveal reflex. Jitender Jinagal, M.S., F.I.C.O., F.A.I.C.O.Poonam Dhiman, M.Optom.Government Medical College and Hospital, Chandigarh, India [email protected]
Mitral regurgitation, left atrial structural and functional remodelling and the effect on pulmonary haemodynamics
Authors: Riccardo M. Inciardi, Andrea Rossi, Corinna Bergamini, Giovanni Benfari, Caterina Maffeis, Carmen Greco, Andrea Drago, Marco Guazzi, Flavio L. Ribichini, Mariantonietta Cicoira
Journal: European Journal of Heart Failure (2019)
New insights of CYP1A in endogenous metabolism: a focus on single nucleotide polymorphisms and diseases
Authors: Jian Lu, Xuyang Shang, Weiguo Zhong, Yuan Xu, Rong Shi, Xin Wang
Journal: Acta Pharmaceutica Sinica B (2019)

Cytochrome P450 1A (CYP1A), one of the major CYP subfamily in humans, not only metabolizes xenobiotics including clinical drugs and pollutants in the environment, but also mediates the biotransformation of important endogenous substances. In particular, some single nucleotide polymorphisms (SNPs) for CYP1A genes may affect the metabolic ability of endogenous substances, leading to some physiological or pathological changes in humans. This review first summarizes the metabolism of endogenous substances by CYP1A, and then introduces the research progress of CYP1A SNPs, especially the research related to human diseases. Finally, the relationship between SNPs and diseases is discussed. In addition, potential animal models for CYP1A gene editing are summarized. In conclusion, CYP1A plays an important role in maintaining the health in the body.
Comprehensive Ultra High Resolution Analysis of Copy Number and Allele Status Including Novel Microdeletions Spanning NF1 in Acute Myelogenous Leukemia
Authors: Sami Malek, Peter Ouillette, Whitney Wright, Amanda Dressel, Judy Karp, Paula Bockenstedt, Ammar Al-Zoubi, Moshe Talpaz, Lisa Kujawski, Kerby Shedden, Sajid Shakhan, Cheng Li, Harry Erba, Brian Parkin
Journal: Blood (2008)
A Phase I/II Dose Escalating Study of Daunorubicin Combined with Imatinib Mesylate and Cytarabine as Induction Therapy for Chronic Myelogenous Leukaemia in Myeloid Blast Crisis. Preliminary Results of the AFR01 Trial.
Authors: Philippe Rousselot, Laurence Legros, Joelle Guilhot, Mauricette Michallet, Francois Xavier Mahon, Cecile Pautas, Denis Guyotat, Agnes Guerci, Christian Berthou, Bernard Rio, Lydia Roy, Patrice Berthaud, Francois Guilhot
Journal: Blood (2004)
Risk of Hepatitis B and Efficacy of Treatment with Lamivudine in Patients Undergoing Allogeneic Stem Cell Transplant.
Authors: Luisa Giaccone, Alfredo Marzano, Isabel Resta, Andrea Marengo, Francesca Fiore, Roberto Sorasio, Moreno Festuccia, Mario Rizzetto, Mario Boccadoro
Journal: Blood (2007)
T-cell phenotyping uncovers systemic features of atopic dermatitis and psoriasis
Authors: Consol Farrera, Rossella Melchiotti, Nedyalko Petrov, Karen Wei Weng Teng, Michael Thomas Wong, Chiew Yee Loh, Federica Villanova, Isabella Tosi, Jinmiao Chen, Katarzyna Grys, Hemawtee Sreeneebus, Anna Chapman, Gayathri K. Perera, Susanne Heck, Filipe Gracio, Emanuele de Rinaldis, Jonathan N. Barker, Catherine H. Smith, Frank O. Nestle, Evan W. Newell, Paola Di Meglio
Journal: Journal of Allergy and Clinical Immunology (2019)
Mechanical Response of Neural Cells to Physiologically Relevant Stiffness Gradients
Authors: Céline Kayal, Emad Moeendarbary, Rebecca J. Shipley, James B. Phillips
Journal: Advanced Healthcare Materials (2019)

Understanding the influence of the mechanical environment on neurite behavior is crucial in the development of peripheral nerve repair solutions, and could help tissue engineers to direct and guide regeneration. In this study, a new protocol to fabricate physiologically relevant hydrogel substrates with controlled mechanical cues is proposed. These hydrogels allow the analysis of the relative effects of both the absolute stiffness value and the local stiffness gradient on neural cell behavior, particularly for low stiffness values (1-2 kPa). NG108-15 neural cell behavior is studied using well-characterized collagen gradient substrates with stiffness values ranging from 1 to 10 kPa and gradient slopes of either 0.84 or 7.9 kPa mm
Disrupting a converging metabolic target turns up the immunologic-heat in pancreatic tumors
Authors: Won Jin Ho, Elizabeth M. Jaffee
Journal: Journal of Clinical Investigation (2019)

Pancreatic ductal adenocarcinomas (PDACs) are classically immunologically cold tumors that have failed to demonstrate a significant response to immunotherapeutic strategies. This feature is attributed to both the immunosuppressive tumor microenvironment (TME) and limited immune cell access due to the surrounding stromal barrier, a histological hallmark of PDACs. In this issue of the JCI, Sharma et al. employ a broad glutamine antagonist, 6-diazo-5-oxo-l-norleucine (DON), to target a metabolic program that underlies both PDAC growth and hyaluronan production. Their findings describe an approach to converting the PDAC TME into a hot TME, thereby empowering immunotherapeutic strategies such as anti-PD1 therapy.
Excellent Overall Survival and Low Incidence of Late Effects in Patients Undergoing Allogeneic Hematopoietic Cell Transplant for Sickle Cell Disease: A Report from the Center for International Blood and Marrow Transplant Research (CIBMTR)
Authors: Elizabeth Stenger, Rachel Phelan, Bronwen E. Shaw, Minoo Battiwalla, Stephanie Bo-Subait, Ruta Brazauskas, David K. Buchbinder, Betty K. Hamilton, Shalini Shenoy, Lakshmanan Krishnamurti
Journal: Blood (2019)
Identification of Prognostic Factors Predicting the Outcome of Reduced Intensity Allogeneic Stem Cell Transplantation in Mantle Cell Lymphoma. An Analysis from the Lymphoma Working Party of the EBMT
Authors: Stephen P Robinson, Anna Sureda, Carmen Canals, Jean-Paul Vernant, Noel-Jean Milpied, Jürgen Finke, Johan Maertens, Jean-Pierre Jouet, Charles F. Craddock, Karl S Peggs, Steven Le Gouill, Norbert Schmitz
Journal: Blood (2008)
Altered Expressions of CD30, c-Jun N-Terminal Kinase, NF-κB and JunB Are Involved in Disease Progression in CD30-Positive Anaplastic Large Cell Lymphoma.
Authors: Tsuyoshi Nakamaki, Hidetoshi Nakashima, Masamichi Hattori, Takako Usui, Takashi Maeda, Kunihiko Fukuchi, Shigeru Tomoyasu
Journal: Blood (2005)
Biologic and Clinical Markers for Outcome after Fludarabine (F) or F Plus Cyclophosphamide (FC) - Comprehensive Analysis of the CLL4 Trial of the GCLLSG.
Authors: Stephan Stilgenbauer, Barbara F. Eichhorst, Raymonde Busch, Thorsten Zenz, Dirk Winkler, Andreas Bühler, Valentin Goede, Clemens M Wendtner, Peter Lichter, Berthold Emmerich, Michael Hallek, Hartmut Döhner
Journal: Blood (2008)
Early life exposure to air pollution and incidence of childhood asthma, allergic rhinitis and eczema
Authors: Teresa To, Jingqin Zhu, Dave Stieb, Natasha Gray, Ivy Fong, Lauren Pinault, Michael Jerrett, Alain Robichaud, Richard Ménard, Aaron van Donkelaar, Randall V. Martin, Perry Hystad, Jeffrey R. Brook, Sharon Dell
Journal: European Respiratory Journal (2019)

Rationale There is growing evidence that air pollution may contribute to the development of childhood asthma and other allergic diseases. In this follow-up of the Toronto Child Health Evaluation Questionnaire (T-CHEQ) study, we examined associations between early life exposures to air pollution and incidence of asthma, allergic rhinitis and eczema from birth through adolescence. Methods 1286 T-CHEQ participants were followed from birth until outcome (March 31, 2016) or loss to follow-up, with a mean of 17 years of follow-up. Concentrations of nitrogen dioxide (NO 2 ), ozone (O 3 ) and particulate matter with a 50% cut-off aerodynamic diameter of 2.5 µm (PM 2.5 ) from January 1, 1999 to December 31, 2012 were assigned to participants based on their postal codes at birth using ground observations, chemical/meteorological models, remote sensing and land-use regression models. Study outcomes included incidence of physician-diagnosed asthma, allergic rhinitis and eczema. Cox proportional hazard regression models were used to estimate hazard ratios per interquartile range of exposures and outcomes, adjusting for potential confounders. Results Hazard ratios of 1.17 (95% CI 1.05–1.31) for asthma and 1.07 (95% CI 0.99–1.15) for eczema were observed for total oxidants (O 3 and NO 2 ) at birth. No significant increase in risk was found for PM 2.5 . Conclusions Exposures to oxidant air pollutants (O 3 and NO 2 ) but not PM 2.5 were associated with an increased risk of incident asthma and eczema in children. This suggests that improving air quality may contribute to the prevention of asthma and other allergic disease in childhood and adolescence.
Endogenous Platelet PF4 Promotes In Vivo Activated Protein C (APC) Generation and Survival after Lethal Lipopolysaccharide Challenge in Mice: A Potential Physiologic Role for PF4.
Authors: M. Anna Kowalska, Shawn A. Mahmud, Mortimer Poncz, Arne Slungaard
Journal: Blood (2005)
Abstract 4562: Long-Term Clinical Outcome and Left Ventricular Remodeling in AMI Patients With Insufficient Myocardial Reperfusion After Recanalization
Authors: Jun Jin, Hong Wang, Yao-Ming Song, Ai-Ming Li, Jun Qin, Xue-Jun Yu, Zhao-Hua Geng, Xiao-Bo Zhou, Gang Zhao, Lan Huang
Journal: Circulation (2009)

Background Myocardial contrast echocardiography (MCE) is effective in predicting myocardial viability and functional recovery on a segmental level in patients with acute myocardial infarction (AMI)...
All Clinically Relevant Leukemia Subtypes Can Be Diagnosed and Classified Based Solely on Gene Expression Profiling with an Accuracy of 95.1%: A Study on 1337 Adult Patients.
Authors: Torsten Haferlach, Alexander Kohlmann, Susanne Schnittger, Martin Dugas, Sylvia Merk, Wolfgang Hiddemann, Wolfgang Kern, Claudia Schoch
Journal: Blood (2004)
Systematic Review of the Cost Effectiveness of Breast Cancer Prevention, Screening, and Treatment Interventions
Authors: Jinani Jayasekera, Jeanne S. Mandelblatt
Journal: Journal of Clinical Oncology (2019)

Article Tools REVIEW ARTICLES Health Services and Outcomes Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.19.01525 Journal of Clinical Oncology - published online before print December 5, 2019 PMID: 31804858 Systematic Review of the Cost Effectiveness of Breast Cancer Prevention, Screening, and Treatment Interventions Jinani Jayasekera, PhD1xJinani JayasekeraSearch for articles by this author and Jeanne S. Mandelblatt, MD, MPH1xJeanne S. MandelblattSearch for articles by this author Show More 1Georgetown-Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC https://doi.org/10.1200/JCO.19.01525 First Page Full Text PDF Figures and Tables © 2019 by American Society of Clinical Oncology
Benign ve malign melanositik lezyonların optik koherans tomografi kullanılarak in vivo karakterizasyonu
Authors: Thilo Gambichler, Philipp Regeniter, Falk G. Bechara, Alexej Orlikov, Remus Vasa, Georg Moussa, Markus Stücker, Peter Altmeyer veKlaus Hoffmann Bochum
Journal: Journal of the American Academy of Dermatology (2008)
Progress and challenges of a pioneering hepatitis C elimination program in the country of Georgia
Authors: Francisco Averhoff, Shaun Shadaker, Amiran Gamkrelidze, Tatia Kuchuloria, Lia Gvinjilia, Vladimer Getia, David Sergeenko, Maia Butsashvili, Tengiz Tsertsvadze, Lali Sharvadze, Jaba Zarkua, Beth Skaggs, Muazzam Nasrullah
Journal: Journal of Hepatology (2019)