tbuckley/cabot-search huggingface dataset:
National and regional hospitalization rates for allergic disorders in the United States: A 17‐year time‐trend analysis
Authors: Primoz Kocbek, Nino Fijacko, Goran Hrovat, Bright I Nwaru, Paige Wickner, Aziz Sheikh, Gregor Stiglic
Journal: Allergy (2019)

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
The Prolonged Inhibition of Chk1/Chk2 Kinases Enhances Genetic Instability and Compromises the Efficacy of Chemotherapy Against Acute Lymphoblastic Leukemia Cells
Authors: Andrea Ghelli Luserna Di Rorà, Antonella Padella, Maria Chiara Fontana, Eugenio Fonzi, Anna Ferrari, Enrica Imbrogno, Martina Ghetti, Roberta Napolitano, Maria Teresa Bochicchio, Giovanni Martinelli, Giorgia Simonetti
Journal: Blood (2019)
TMIC-45. RADIATION THERAPY-INDUCED EPIGENETIC REWIRING PROMOTES GLIOMA PHENOTYPIC PLASTICITY
Authors: Sree Deepthi Muthukrishnan, Qing Wang, Yue Qin, Riki Kawaguchi, Maverick Johnson, Rachna Prasad, Michael Condro, Harley Kornblum
Journal: Neuro-Oncology (2019)

Abstract Therapeutic failure and relapse of glioblastoma (GBM) tumors is attributed to a fraction of chemo- and radiation-resistant glioma stem cells (GSCs). Growing evidence indicates that GSCs and tumor cells elicit phenotypic plasticity in response to radiation-therapy (RT) such as de-differentiation and acquisition of a GSC-like state, and epithelial-to- mesenchymal transition (EMT) leading to more aggressive tumors and relapse. Preliminary findings from our laboratory indicate that RT also promotes vascular transdifferentiation of glioma cells, and the transdifferentiated vascular cells are essential for tumor growth in vivo. Together, these studies suggest that RT alters the dynamic equilibrium between “stemness” and “differentiation” states of the tumor cells. Transition between different cellular states or phenotypes required global alterations in chromatin landscape and associated transcriptional changes, and this epigenetic rewiring process is observed in several stages of oncogenesis and metastatic transformation. We hypothesized that epigenetic rewiring occurs in GBM tumor cells that survive radiation-induced DNA damage altering their cell fate that leads to diverse phenotypic outcomes such as EMT, acquisition of stem-like state and vascular transdifferentiation. Preliminary findings from bulk ATAC- and RNA-sequencing of patient-derived gliomasphere lines show that RT increases chromatin accessibility, and reduces expression of several histone components and their chaperones. Gene ontology and transcription factor motif analyses of open chromatin regions showed an enrichment of factors and terms related to pluripotency, vascular specification and stem cell differentiation. Furthermore, single-cell RNA-sequencing of radiated and control tumor cells also showed an increase in vascular markers expressing-clusters, and reduction in expression of histone components post radiation supporting our hypothesis that RT causes epigenetic rewiring in glioma cells leading to diverse phenotypic outcomes including vascular transdifferentiation. Ongoing experiments are aimed at determining the precise molecular mechanism by which RT causes chromatin rewiring, and identifying candidates involved in this process for therapeutic targeting.
Age and Time to Progression Predict Overall Survival (OS) in Patients with Diffuse Large B-Cell Lymphoma (DLBCL) Who Progress Following Frontline Immunochemotherapy (IC)
Authors: Matthew J. Maurer, Lasse H. Jakobsen, Norbert Schmitz, Umar Farooq, Christopher R. Flowers, Peter de Nully Brown, Carrie A. Thompson, Henrik Frederiksen, David Cunningham, Judit Jørgensen, Viola Poeschel, Grzegorz Nowakowski, John F. Seymour, Francesco Merli, Corinne Haioun, Herve Ghesquieres, Marita Ziepert, Herve Tilly, Gilles Salles, Qian Shi, Tarec Christoffer C. El-Galaly, Thomas M. Habermann
Journal: Blood (2019)
"Unjustified" Use of d-Tubocurarine Chloride
Authors: H. V. Corbett
Journal: BMJ (1947)

These, Sir, are briefly the findings in this case, and I consider it rare and interesting for the following reasons. (1)The heart condition seems to have been a toxic myocarditis causing ectopic ventricular beats.(2) The toxaemia was mild, causing no temperature or tachycardia. (3)In my library I cannot find any cardiograms like the tracings found in this case. (4)The clinically alarming condition of her heart and the rapidity with which it cleared up.-I am, etc., Roscommon, Eire.
Bacteriological Examination of Urine
Authors: J. G. Davis
Journal: BMJ (1963)

must be inhaled in order to produce asbestesis ?" Although we have no answer directly applicable to man, we do have some indirect evidence that fairly heavy concentrations of asbestos dust are required to produce alveolar fibrosis in animals.Thus, in one experimental investigation' exposure to inadequate concentra- tions of asbestos dust has been held responsible for the dictum that short- fibred asbestos dust was non-pathogenic,' a concept now believed erroneous.4'-Wehave found 10 mg. of short-fibred chryso- tile dust injected intratracheally in rats to produce only transient focal fibrosis' and exposure of guinea-pigs and rats to ex- tremely fine chrysotile dust (19 mg./ c.mm.) for three and a half months resulted in barely perceptible fibrosis in some animals and none in others as long as 10 months later.The implications in Professor Thom- son's communications point up the need for more direct data than are now avail- able on the minimal amount of asbestos dust required for the production of recog- nizable asbestotic alveolar fibrosis.Our present information, although indirect, suggests that asbestos dust is less patho- genic than is quartz dust on a weight for weight basis.-Iam, etc.,
Optimal Dual-Targeted CAR Construct Simultaneously Targeting Bcma and GPRC5D Prevents Bcma-Escape Driven Relapse in Multiple Myeloma
Authors: Carlos Fernandez de Larrea, Mette Staehr, Andrea Lopez, Yunxin Chen, Terence J Purdon, Khong Y. Ng, Hans Wendel, Renier J. Brentjens, Eric L Smith
Journal: Blood (2019)
Safety, pharmacokinetics, and antiviral effects of ABI-H0731, a hepatitis B virus core inhibitor: a randomised, placebo-controlled phase 1 trial
Authors: Man-Fung Yuen, Kosh Agarwal, Edward J Gane, Christian Schwabe, Sang Hoon Ahn, Dong Joon Kim, Young-Suk Lim, Wendy Cheng, William Sievert, Kumar Visvanathan, Eric Ruby, Sandy Liaw, Ran Yan, Qi Huang, Richard Colonno, Uri Lopatin
Journal: The Lancet. Gastroenterology & hepatology (2019)
TMIC-48. MACROPHAGE DEPLETION COMBINED WITH RADIATION IN A PRECLINICAL MEDULLOBLASTOMA MODEL
Authors: Erin Crotty, Ken Brasel, Fiona Pakiam, Emily Girard, James Olson
Journal: Neuro-Oncology (2019)

Abstract BACKGROUND Radiation induces a measurable immune response, yet this anti-tumor immunity is often suboptimal at eliminating residual brain tumor cells. Medulloblastomas, along with other pediatric brain tumors, tend to recur in the primary resection bed following irradiation. Infiltrating macrophage within the tumor (TAM) are radioresistant immune cells that may limit the effectiveness of radiotherapy and promote tumor regrowth through their immunosuppressive and pro-tumorigenic functions. Therefore, we explored whether CSF-1 receptor (CSF1R) inhibition, and essentially TAM depletion, could augment radiation and/or reduce local recurrence. METHODS Selected CSF1R inhibitors were tested on both human and mouse macrophage in vitro. In vivo studies were performed on a patient-derived orthotopic xenograft (PDOX) model of Group 3 medulloblastoma, Med411-FH. Macrophage depletion was achieved using the anti-murine CSF1R antibody, AFS98, injected intra-peritoneally 10 days prior to, concurrently, and after radiation. RESULTS CSF1R antibodies and small molecule tyrosine kinase inhibitors were effective at stanching macrophage survival in culture. In a PDOX medulloblastoma model, both classes of CSF1R inhibitors were effective at reducing macrophage in the brain after approximately 10 days of administration, with maximal effect of 90% depletion achieved after 21 days. In a combinatorial study of AFS98 and irradiation, TAM depletion conferred a very modest effect on tumor growth (p=0.003) and had no effect on overall survival when combined with radiation (p=0.86). Interestingly, we did observe a trend toward reduction in metastatic spinal disease following radiation in the AFS98-treated cohort. CONCLUSION CSF1R antibody administration effectively eliminated macrophage and microglia in the brain and spine, suggesting adequate blood-brain barrier penetration in our xenograft model. While CSF1R inhibition combined with radiation was ineffective at prolonging survival, further studies are needed to investigate a modest effect on brain tumor growth and an observed (yet not statistically significant) difference in metastatic spinal recurrence in drug-treated animals.
Phase 1b Study of the Epichaperome Inhibitor PU-H71 Administered Orally with Ruxolitinib Continuation for the Treatment of Patients with Myelofibrosis
Authors: Naveen Pemmaraju, Krishna Gundabolu, Kristen Pettit, Moshe Talpaz, Nikolai A. Podoltsev, Gary J. Schiller, Peter Eisenberg, Hagop Youssoufian, Susan Duggan, Barbara Wallner, Srdan Verstovsek
Journal: Blood (2019)
RTHP-11. THE EFFECT OF PRESCRIPTION ISODOSE LINE ON LOCAL CONTROL AND RADIOGRAPHIC RESPONSE IN GAMMA KNIFE RADIOSURGERY OF VESTIBULAR SCHWANNOMA
Authors: Achiraya Teyateeti, Christopher Graffeo, Avital Perry, Paul Brown, Bruce Pollock, Link Michael
Journal: Neuro-Oncology (2019)

Abstract Traditionally, the 50% isodose line (IDL) is used for prescription dose when vestibular schwannomas (VS) are treated with Gamma Knife radiosurgery (GKRS). To compare the effect of IDL on treatment outcomes, propensity score-matched analysis according to age at time of GKRS and tumor volume (TV) between cohorts treated at 40%IDL and 50%IDL was performed. Patients with no history of neurofibromatosis, GKRS prescribed marginal dose of 12–14 Gy and TV ≤ 10 cc were identified. Patients were excluded if follow-up time was &lt; 2 years. Eventually, 30 and 28 patients were included in 40%IDL and 50%IDL cohorts, respectively. Mean age and TV were not significantly different between 40%IDL and 50%IDL groups; 54.5 versus 54.0 years (p=0.891) and 2148.61 versus 2031.10 mm3 (p=0.844), respectively. Median prescription dose was 12 Gy in both groups. At median follow-up times of 111 and 72 months, the 2, 5 and 10-year local control were 100%, 96.4% and 96.4% for 40%IDL and 96.4%, 86.7%, and 86.7% for 50%IDL (p=0.243), respectively. Among 40 patients with accessible follow-up MRIs (40%IDL-n=19, 50%IDL-n=21), volume reduction at last follow-up MRIs and rate of reduction per year for 40%IDL and 50%IDL were 48.1% versus 38.3% (p=0.05) and 5.5% versus 6% (p=0.749), respectively. Of 21 patients with serviceable hearing prior to GKRS and available audiograms after GKRS (40%IDL-n=8, 50%IDL-n=13), the 2, 5 and 10-year hearing preservation rate were 100%, 83.3% and 62.5% for 40%IDL versus 76.2%, 57.1% and 11.4% for 50%IDL (p=0.017). Facial paresthesia, facial palsy and ataxia/gait disturbance requiring steroid and/or shunt were lower in 40%IDL compared to the 50%IDL; 6.7% versus 17.9% (p=0.208) and 3.3% versus 7.1% (p=0.532). To summarize, VS treated at 40%IDL have slightly better local control, although not statistically significant, compared to tumors treated at 50%IDL. However, hearing preservation and safety seem to be more favorable toward 40%IDL group.
Correlation of CD123 Expression Level with Disease Characteristics and Outcomes in Pediatric Acute Myeloid Leukemia: A Report from the Children's Oncology Group
Authors: Adam J. Lamble, Lisa Eidenschink Brodersen, Todd A. Alonzo, Jim Wang, Robert B. Gerbing, Laura Pardo, Lillian Sung, Sarah K. Tasian, Todd M Cooper, E. Anders Kolb, Richard Aplenc, Michael R. Loken, Soheil Meshinchi
Journal: Blood (2019)
EPID-01. SEX DIFFERENCE IN EXPRESSION OF IRON-RELATED GENES AND SURVIVAL IN GLIOBLASTOMA PATIENTS
Authors: Sang Lee, Vonn Walter, Anna Salzberg, Darya Nesterova, Justin Lathia, Joshua Rubin, Michael Berens, Jill Barnholtz-Sloan, James Connor
Journal: Neuro-Oncology (2019)

Abstract Sex impacts the clinical outcome of glioblastoma (GBM) patients. Iron is a key metabolic driver in glioma biology impacting both the neoplastic cells directly and tumor progression through the immune system. We previously reported the expression of HFE (iron homeostatic) gene has a sexually dimorphic impact on survival in GBM patients. To further interrogate the relationship of iron and sexual dimorphism in GBMs, we expanded our analysis to include the ferrome (profile of genes and proteins involved in iron regulation). These genes were identified using IronChip and then interrogated for sexually dimorphic expression and survival in primary GBM patients using The Cancer Genome Atlas GBM database. Biological pathway analysis indicated that the Toll receptor signaling and immune system signaling pathways are most strongly correlated to sex difference and GBM patient survival. Toll like receptor 4 (TLR4) expression in the bottom quartile is associated with a modest survival benefit for female GBM patients compared to male, but in the top quartile of expression of this gene the survival for males is dramatically greater than that for females (18 months versus 3.6 months). Males expressing top quartile of Dual specificity phosphatases (DUSP1) also known as MKP1 survive 24.2 months whereas females survive 5.8 months. There is no sex effect of DUSP1 in the bottom quartile of expression. These data suggest that top quartile expression of TLR4/DUSP1 are both a benefit for males (extending their survival) and a detriment to females (shortening their survival). Both TLR4 and DUSP1 are richly expressed in macrophages. The data suggest that macrophage infiltration into the tumor could be particularly negatively impactful in females; a finding consistent with our previous reports for the HFE gene. In summary, iron related gene expression is linked to sexual dimorphism in survival and may provide insights on sex specific tumor biology.
Remission in Diabetes
Authors: A. Bloom
Journal: BMJ (1959)

MEDIu 731 the demonstration' that a candidate is a 452 does not add any useful4iformation regarding his abilities.But if his physique is outside the demonstrated distribution of swimmier-canoeists, it seems unlikely that he will be suitable for training.Experienced instructors probably use this knowledge intuitively, but a prospective study of trainees with progress reports might, it is suggested, prove a useful next step.Summary A study has been made of the physique of 160 men serving in the Royal Marines.Those in the more hazardous branches are shown to have a more muscular physique.This is considered to be in keeping with Sheldon's thesis that a relation exists between muscularity and somatotonic traits of temperament.I wish to acknowledge my thanks to the Medical Director-
Hypotensive reaction after propanidid and atropine.
Authors: T S Clarke, J W Dundee
Journal: BMJ (1969)

BRnTnS 369 raises the point that the presence of the prune-belly syndrome in an older child should be unacceptable because it represents failure to apply early preventive treatment.In addition to the psychological and cos- metic benefit it might well be that the stronger abdominal wall would also be a positive advantage in the child's urinary dynamics.-Iam, etc.,
Non-pharmacological therapeutic strategy options for patients with dementia based on cognitive function—A Bayesian network meta-analysis of randomized controlled trials
Authors: Jing-hong Liang, Lu Lin, Ying-quan Wang, Rui-xia Jia, Xin-yuan Qu, Jing Li, Jia-yu Li, Sheng Qian, Yu-xi Qian, Shan Wang, Zhen Gao, Xing-xue Cheng, Yong Xu
Journal: Ageing Research Reviews (2019)
Medical Practices Committee
Authors: D. M. O'Connor
Journal: BMJ (1974)

is no evidence that the teaching and effective implementation of such safety measures are carried out at the place of work.As Mr. Bagley so rightly suggests, occupationally based health services could help enormously in reducing the work load on the busy accident and emergency depart- ments and could certainly save a great deal of time lost at work, but i.t must be borne in mind that unless such services can be aimed at prevention as well as treatment of injuries within their scope, then it could create more rather than less work for those departments.-Iam, etc.,
"Identification of Mechanisms By Which Mesenchymal Stem/Stromal Cells Contribute to Acute Myeloid Leukemia"
Authors: Allolo Aldreiwish, Gauri Muradia, Remi Gagne, Marc Beal, Carole Yauk, David S. Allan, Rafael Diaz de la Guardia, Pablo Menendez, Michael Rosu-Myles, Jessie .R. Lavoie
Journal: Blood (2019)
Fludarabine Melphalan Versus Fludarabine Treosulfan As Reduced Intensity Conditioning Regimens in Allogeneic Hematopoietic Stem Cell Transplant - a Retrospective Analysis
Authors: Akanksha Chichra, Lingaraj Nayak, Rushabh Kothari, Siddhesh Arun Kalantri, Avinash Bonda, Anant Gokarn, Sachin Punatar, Bhausaheb Bagal, Sadhana Kannan, Libin J Mathew, Navin Khattry
Journal: Blood (2019)
Factors Associated With Mortality After Emergency Colectomy for Acute Lower Gastrointestinal Bleeding
Authors: Colin Sue-Chue-Lam, Matthew Castelo, Nancy N. Baxter
Journal: JAMA Surgery (2019)

This cohort study uses data from the National Surgical Quality Improvement Program database to examine factors associated with mortality risk among patients undergoing emergency colectomy for acute lower gastrointestinal bleeding.
Phase I Dose-Escalation Study of Venetoclax Plus BEAM Followed By Autologous Stem Cell Transplant (ASCT) for Chemoresistant or High-Risk Relapsed/Refractory Non-Hodgkin Lymphoma (NHL)
Authors: Joseph Maakaron, Qiuhong Zhao, Marcin Puto, Quinn Verfurth, Sam Penza, Jonathan E Brammer, Yvonne A. Efebera, Ashley E. Rosko, Ayman Saad, Samantha Jaglowski, Basem M. William
Journal: Blood (2019)
Characterizing C5 Inhibition with the SMART-Ig Anti-hC5 Antibody Crovalimab in PNH Patients Using Free Available Paratopes
Authors: Alexandre Sostelly, Antoine Soubret, Christoph Bucher, Simon Buatois, Jean-Eric Charoin, Gregor Jordan, Barbara Klughammer, Andreas Dieckmann, Taku Fukuzawa, Keisuke Gotanda, Kenji Shinomiya, Sung-Soo Yoon, Jens P. Panse, Junichi Nishimura, Alexander Röth, Zsolt Nagy, Régis Peffault de Latour
Journal: Blood (2019)
Risk Factors and Outcomes of Patients with Follicular Lymphoma Who Had Histologic Transformation at First Progression after First-Line Immunochemotherapy in the Gallium Study
Authors: Carla Casulo, Michael Herold, Wolfgang Hiddemann, Sunil Iyengar, Robert E. Marcus, John F. Seymour, Aino Launonen, Andrea Knapp, Tina G Nielsen, Farheen Mir
Journal: Blood (2019)
Combined Heterozygous Loss of Tet2 and Dnmt3a Along with Expression of Flt3ITD/WT results in Acute Myeloid Leukemia Which Responds to a Combination of FLT3 Inhibitor, APE1 Inhibitor and Decitabine
Authors: Baskar Ramdas, Lakshmi Reddy Palam, Raghuveer Singh Mali, Zhigang Cai, Ruchi Pandey, Reuben Kapur
Journal: Blood (2019)
CLL B Cells Develop Resistance to Ibrutinib By Reinvigorating the IL-4R - IL-4 Axis Blocked By Bruton's Tyrosine Kinase Inhibitors Including Acalabrutinib and Zanubrutinib
Authors: Shih-Shih Chen, Constantine S. Tam, Alan G. Ramsay, Priyadarshini Ravichandran, Natalia C. Couto-Francisco, Michael Ibrahim, Gerardo Ferrer, Jonathan E. Kolitz, Steven L. Allen, He Zhou, Jacqueline C Barrientos, Kanti R Rai, Nicholas Chiorazzi
Journal: Blood (2019)
The effect of anesthesia choice on post-operative outcomes in women undergoing exploratory laparotomy for gynecologic malignancy.
Authors: Colleen Lee Rivard, Elizabeth Louise Dickson, Rachel Isaksson Vogel, Deanna Gek Koon Teoh
Journal: Journal of Clinical Oncology (2013)

e20571 Background: The goal of this study is to examine how regional anesthesia choice in women undergoing laparotomy for gynecologic malignancy affects their pain and hospital stay. Methods: This single-institution retrospective review studied women undergoing exploratory laparotomy for suspected gynecologic malignancy from May to January 2013. Patients were in 1 of 3 groups: patient controlled analgesia (PCA), transversus abdominis plane (TAP) blocks with PCA or transthoracic epidural. Narcotic use and pain scale during the first 3 days after surgery, length of surgery, complications and length of postoperative stay were compared. P-values of &lt;0.05 are considered significant. Results: One hundred twelve women were included (44 PCA, 30 TAP + PCA, 38 epidural). Those receiving TAP or epidural tended not to use narcotic prior to surgery, though not a statistically significant result. The length of surgery and estimated blood loss were not different between groups; however, the rate of intra-operative complications differed by pain management method (p=0.020), with those who received an epidural had the lowest rate. In the epidural group, median IV narcotic use (mg) was significantly decreased for the first three post-surgical days (day 1 p =0.014; day 2 p &lt;0.0001; day 3 p = 0.048). Those with epidurals also had significantly lower pain scales on the second and third post-operative days compared to those with TAP or PCA alone (day 2: p=0.046; day 3: p =0.008). After adjusting for age and complications arising both during and after surgery, TAP placement increased the length of hospital stay slightly by 0.35 days (95% CI: 0.07-0.62 days, p=0.014). Conclusions: The use of epidural anesthesia for post-operative pain management in surgery for gynecologic malignancy decreases narcotic analgesia use and improves pain scale measurements without increasing complications or length of hospital stay. Further investigation with prospective randomized trials is warranted to elucidate the optimal post-operative pain management technique.
When was the First Gastrectomy?
Authors: R. G. Richardson
Journal: BMJ (1964)

SIR,-In the House of Commons on 2 December 1963 Dr. Dickson Mabon asked the Minister of Health to make a statement on the provision ofa free service of sterile syringes for use in the general medical service.Mr. Braine replied that the Minister had authorized hospitals to provide sterile syringes free of charge to general practitioners for taking specimens for examination in hospital laboratories.This was an unsatisfactory question and answer.Firstly, it was unnecessary; second, it encouraged false hopes; third, the idea of a " sterile syringe service " based on a hos- pital sterilizing unit was obsolete.It was unnecessary because for many years some hospitals (notably that at Kingston-upon- Thames) have been providing such a service;
Comparison of Overall Responses after Standard Induction with High Dose Daunorubicin Versus Standard Dose Daunorubicin with Gemtuzumab Ozogamicin in Favorable Risk Acute Myeloid Leukemia
Authors: Chetasi Talati, Ryan J Caddell, Katherine Tobon, Rami S. Komrokji, Andrew T Kuykendall, Eric Padron, Hugo F. Fernandez, Alan F. List, David A Sallman, Kendra L. Sweet, Jeffrey E. Lancet
Journal: Blood (2019)
Phenotypic Characterization of the Immune Landscape in the Bone Marrow of Patients with Acute Myeloid Leukemia (AML) Using MultiOmyxTM Hyperplexed Immunofluorescence Assay
Authors: Qingyan Au, Arezoo Hanifi, Erinn Parnell, Judy Kuo, Eric Leones, Flora Sahafi, Mate Nagy, Josette William
Journal: Blood (2019)