tbuckley/cabot-search huggingface dataset:
Effect of a Patient Decision Aid on Lung Cancer Screening Decision-Making by Persons Who Smoke
Authors: Robert J. Volk, Lisa M. Lowenstein, Viola B. Leal, Kamisha H. Escoto, Scott B. Cantor, Reginald F. Munden, Vance A. Rabius, Linda Bailey, Paul M. Cinciripini, Heather Lin, Ashley J. Housten, Pamela Graef Luckett, Angelina Esparza, Myrna C. Godoy, Therese B. Bevers
Journal: JAMA Network Open (2020)

<h3>Importance</h3> Lung cancer screening with low-dose computed tomography lowers lung cancer mortality but has potential harms. Current guidelines support patients receiving information about the benefits and harms of lung cancer screening during decision-making. <h3>Objective</h3> To examine the effect of a patient decision aid (PDA) about lung cancer screening compared with a standard educational material (EDU) on decision-making outcomes among smokers. <h3>Design, Setting, and Participants</h3> This randomized clinical trial was conducted using 13 state tobacco quitlines. Current and recent tobacco quitline clients who met age and smoking history eligibility for lung cancer screening were enrolled from March 30, 2015, to September 12, 2016, and followed up for 6 months until May 5, 2017. Data analysis was conducted between May 5, 2017, and September 30, 2018. <h3>Interventions</h3> Participants were randomized to the PDA video<i>Lung Cancer Screening: Is It Right for Me?</i>(n = 259) or to EDU (n = 257). <h3>Main Outcomes and Measures</h3> The primary outcomes were preparation for decision-making and decisional conflict measured at 1 week. Secondary outcomes included knowledge, intentions, and completion of screening within 6 months of receiving the intervention measured by patient report. <h3>Results</h3> Of 516 quit line clients enrolled, 370 (71.7%) were younger than 65 years, 320 (62.0%) were female, 138 (26.7%) identified as black, 47 (9.1%) did not have health insurance, and 226 (43.8%) had a high school or lower educational level. Of participants using the PDA, 153 of 227 (67.4%) were well prepared to make a screening decision compared with 108 of 224 participants (48.2%) using EDU (odds ratio [OR], 2.31; 95% CI, 1.56-3.44;<i>P</i> &lt; .001). Feeling informed about their screening choice was reported by 117 of 234 participants (50.0%) using a PDA compared with 66 of 233 participants (28.3%) using EDU (OR, 2.56; 95% CI, 1.72-3.79;<i>P</i> &lt; .001); 159 of 234 participants (68.0%) using a PDA compared with 110 of 232 (47.4%) participants using EDU reported being clear about their values related to the harms and benefits of screening (OR, 2.37; 95% CI, 1.60-3.51;<i>P</i> &lt; .001). Participants using a PDA were more knowledgeable about lung cancer screening than participants using EDU at each follow-up assessment. Intentions to be screened and screening behaviors did not differ between groups. <h3>Conclusions and Relevance</h3> In this study, a PDA delivered to clients of tobacco quit lines improved informed decision-making about lung cancer screening. Many smokers eligible for lung cancer screening can be reached through tobacco quit lines. <h3>Trial Registration</h3> ClinicalTrials.gov identifier:NCT02286713
Treatment of Iron Deficiency After Gastric Bypass
Authors: Michael Auerbach
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Novel coronavirus (2019-nCoV) early-stage importation risk to Europe, January 2020
Authors: Giulia Pullano, Francesco Pinotti, Eugenio Valdano, Pierre-Yves Boëlle, Chiara Poletto, Vittoria Colizza
Journal: Eurosurveillance (2020)

As at 27 January 2020, 42 novel coronavirus (2019-nCoV) cases were confirmed outside China. We estimate the risk of case importation to Europe from affected areas in China via air travel. We consider travel restrictions in place, three reported cases in France, one in Germany. Estimated risk in Europe remains high. The United Kingdom, Germany and France are at highest risk. Importation from Beijing and Shanghai would lead to higher and widespread risk for Europe.
Prevalence and impact of nasal hyperreactivity in chronic rhinosinusitis
Authors: Maria Doulaptsi, Brecht Steelant, Emmanuel Prokopakis, Despo Ierodiakonou, Zinovia Tsinaslanidou, Leen Cools, Benoit Pugin, Athanasia Milioni, Laura Van Gerven, Wytske J. Fokkens, Jiannis Constantinidis, Peter W. Hellings
Journal: Allergy (2020)

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Factor VIII Fc Fusion Protein but not FVIII Drives Human Monocyte‐Derived Dendritic Cell Activation via FcγRIIa
Authors: Christoph Kannicht, Ilona Danßmann, Constanze Weilandt, Katja Derkow, Guido Kohla, Henriette Geyer
Journal: HemaSphere (2020)

This study compares the effect of recombinant Factor VIII Fc fusion protein (rFVIII-Fc) with recombinant FVIII (rFVIII) on monocyte-derived dendritic cells (moDC's). Cells treated with rFVIII-Fc showed morphological changes typical for cell activation, had a significant up-regulation of cell activation markers and produced higher levels of pro-inflammatory cytokines. Even after stimulation with Lipopolysaccharides, the addition of rFVIII-Fc led to increased expression of activation markers, indicating that rFVIII-Fc is capable of amplifying the maturation signal. On the contrary, cultivation of moDC's with rFVIII did not alter cell morphology or increase surface activation marker expression and pro-inflammatory cytokine production. The binding of the Fc domain to the activating Fcγ receptor IIa (FcγRIIa) can cause cell activation. Therefore, the effect of rFVIII-Fc on FcγRIIa was analyzed in detail. Cultivation of moDC's with rFVIII-Fc led to increased phosphorylation of FcγRIIa, which was not detected for rFVIII. Blocking FcγRIIa prior to the cultivation with rFVIII-Fc significantly reduced the activating effect of rFVIII-Fc, indicating that rFVIII-Fc-induced moDC activation was caused by FcγRIIa. Moreover, rFVIII-Fc bound to FCGR2A-transfected human embryonic kidney 293 cells. Taken together, our data present a new mechanism of moDC activation by rFVIII-Fc via FcγRIIa.
Nano-particle mediated M2 macrophage polarization enhances bone formation and MSC osteogenesis in an IL-10 dependent manner
Authors: Olwyn R. Mahon, David C. Browe, Tomas Gonzalez-Fernandez, Pierluca Pitacco, Ian T. Whelan, Stanislas Von Euw, Christopher Hobbs, Valeria Nicolosi, Kyle T. Cunningham, Kingston H.G. Mills, Daniel J. Kelly, Aisling Dunne
Journal: Biomaterials (2020)
Abstract 435: Controlled Sequential Elevation of the Head and Thorax Rapidly Achieves 50% of Baseline Cerebral Perfusion Pressure During Active Compression-Decompression Cardiopulmonary Resuscitation With an Impedance Threshold Device in a Swine Model of Cardiac Arrest
Authors: Carolina Rojas-Salvador, Bayert Salverda, Johanna C Moore, Michael C Lick, Guillaume P Debaty, Keith G Lurie
Journal: Circulation (2019)

Introduction: Controlled sequential elevation of the head and thorax (CSE) during active compression-decompression (ACD) CPR with an impedance threshold device (ITD) has previously resulted in sustained nearly normal cerebral perfusion pressures (CerPP) of 75 mmHg. However, the optimal speed of CSE remains unknown. It is also unknown if some CPR is needed to ‘prime the system’ prior to maximal CSE. Hypothesis: An optimized CSE will achieve 50% of baseline (50% BL) CerPP in &lt;3 minutes from the start of CPR. Methods: Female farm pigs were intubated and anesthetized. Central vascular and intracranial access were obtained. After 8 min of untreated ventricular fibrillation, pigs were placed in a customized elevation device (CED). After 2 min of ACD+ITD CPR at the lowest CED level to prime the circulation, pigs were randomized to CSE over 1) 4-min or 2) 10-min until the CED reached its highest level. ACD ITD CPR was performed for a total of 19 minutes. Based upon initial results, two additional groups of pigs were studied: one with a CSE over 2-min after the 2 min ‘priming’ step, and the other with CSE over 24-sec without priming. The primary outcome was time in minutes to achieve 50% BL of CerPP values. Results: There were six pigs per study group (4-min, 10-min, 2-min and 24-sec). The 4-min CSE group achieved 50% BL CerPP faster (min ± SD) than the 10-min CSE group (2.53 ± 1.26 vs 5.98 ± 3.16 , p=0.04, Figure 1). The 2-min CSE group CerPP was similar to the 4-min group (2.36 ± 2.18, p=0.92). The time to 50% BL CerPP trended 4 min faster in the 2-min CSE group versus the 24-sec CSE group (6.6 ± 6.73, p=0.16), as shown in the figure. With CSE, CerPPs increased over time in all groups. All pigs were resuscitated. Conclusions: A 50% BL CerPP value was achieved in &lt;3 minutes by combining a priming step and 2-min CSE time together with ACD+ITD CPR. This optimized approach is more advantageous than the 24-sec or 10-min elevation times.
Comparative hepatitis C genotype 1–3 viral load kinetics in response to directly-acting antiviral therapy
Authors: Shoshanna May, Feza Kurmoo, Mariesa Iliffe, Joicy David, Ayushi Patel, Martin Wiselka, Iain Stephenson, Toby Delahooke, Florence Y Lai, Simon Dustan, Julian W Tang
Journal: Journal of Infection (2020)
Final report from Intergroup NCCTG 86-72-51 (Alliance): a phase III randomized clinical trial of high-dose versus low-dose radiation for adult low-grade glioma
Authors: William G Breen, S Keith Anderson, Xiomara W Carrero, Paul D Brown, Karla V Ballman, Brian P O’Neill, Walter J Curran, Ross A Abrams, Nadia N Laack, Ralph Levitt, Evanthia Galanis, Jan C Buckner, Edward G Shaw
Journal: Neuro-Oncology (2020)

The optimal radiation dose for adult supratentorial low-grade glioma is unknown. The aim of this study was to provide a final update on oncologic and cognitive outcomes of high-dose versus low-dose radiation for low-grade glioma.Between 1986 and 1994, 203 patients with supratentorial low-grade glioma were randomized (1:1) to 50.4 Gy in 28 fractions versus 64.8 Gy in 36 fractions after any degree of resection.For all patients, median overall survival (OS) was 8.4 years (95% CI: 7.2-10.8). Median progression-free survival (PFS) was 5.2 years (95% CI: 4.3-6.6). Median follow-up is 17.2 years for the 33 patients still alive. High-dose radiation did not improve 15-year OS (22.4%) versus low-dose radiation (24.9%, log-rank P = 0.978) or 15-year PFS (high dose, 15.2% vs low dose, 9.5%; P = 0.7142). OS was significantly better for patients with preoperative tumor diameter <5 cm and baseline Mini-Mental State Examination (MMSE) >27 and who underwent gross total resection. PFS was improved for patients with oligodendroglioma versus astrocytoma, preoperative tumor diameter <5 cm, patients who had gross total resection, and patients with baseline MMSE >27. For patients who had normal MMSE at baseline, at 7 years only 1 patient (5%) had a clinically significant decrease in MMSE from the previous time point, with the remainder (95%) stable. None had decrease in MMSE at 10, 12, or 15 years.Long-term follow-up indicates no benefit to high-dose over low-dose radiation for low-grade gliomas. Cognitive function appeared to be stable after radiation as measured by MMSE.
General epidemiologic colorectal cancer profile in Oncologos del Occidente from Colombia, South America.
Authors: Tomas Sanchez Villegas, Carlos Raul Villegas Mejia, Jose Arnoby Chacon Cardona
Journal: Journal of Clinical Oncology (2013)

e14693 Background: The Colorectal Cancer is one of the most common cancer in the US and the fourth cancer for the developing countries like in our area. Methods: This is a preliminary and partial report of a retrospective analysis from our cancer records in Oncologos del Occidente a Private Oncologic Cancer Center from Colombia. Results: 663 patients (50% of final report) from January 1997 to June 2012 with Colon Cancer 306(46%), Rectal Cancer 309(47%) y Anal Cancer (7%); 51% female; median age 60(range 16-92. sd:13.929); Urban Area 91%. Clinical stage I (7%), IIA (19%), IIB (3%), IIIA (5%), IIIB (13%) and IIIC (10%), IV (11%), Adenocarcinoma 81%, Mucinous (8%); Well differentiated (63%), Poorly differentiated (7%); pretreatment Carcino-embryonic antigen mean 32.778 ng/ml (range 0.18-550.0), Adverse prognostic factors were Obstruction (39%), Ulceration (31%), Lymph Vascular Invasion (10%), T4 Stage (5%), Perforation (4%), Positive Surgical Margin (2%) with two factors 21% and three factors 7%; Low rectal cancer was 90%, Non-Surgical treatment was Chemotherapy (CT) (37%), CT/Radiotherapy (RT) (35%), CT and RT (8%), RT (3%), None (16%); preoperative treatment 37%, First line CT was based on 5FU/LV (52%); 20% relapsed and the main recurrence pattern was Local-marginal (25%), Liver (17%), Pelvic peritoneal (3%), Carcinomatosis (8%) and Lung (23); Rescue treatment was CT (10%), Surgery+CT (1%), CT+RT (1%) and Surgery (1%); the main rescue CT was Folfox 2%, 5FU/LV (3%), Capecitabine (3%), Mixed 6%; Surgical Lymph nodes mean excised was 10.037 (0-38 SD.7.554) and positive nodes mean was 1.972(0-29 SD 3.503); Overall Survival at 5 years for Colon cancer is 63% and 53% to 10 years and Rectal cancer to 5 and 10 years is 45% and 36% respectively (p=0.001). Conclusions: These results reflect the colorectal cancer behavior in a specific area of Colombia and the importance of a multidisciplinary work.
Anti-CDCP1 immuno-conjugates for detection and inhibition of ovarian cancer
Authors: Brittney S. Harrington, Yaowu He, Tashbib Khan, Simon Puttick, Paul J. Conroy, Thomas Kryza, Tahleesa Cuda, Kamil A Sokolowski, Brian WC Tse, Katherine K. Robbins, Buddhika J. Arachchige, Samantha J. Stehbens, Pamela M. Pollock, Sarah Reed, S. John Weroha, Paul Haluska, Carlos Salomon, Rohan Lourie, Lewis C. Perrin, Ruby H. P. Law, James C. Whisstock, John D Hooper
Journal: Theranostics (2020)

CUB-domain containing protein 1 (CDCP1) is a cancer associated cell surface protein that amplifies pro-tumorigenic signalling by other receptors including EGFR and HER2.Its potential as a cancer target is supported by studies showing that anti-CDCP1 antibodies inhibit cell migration and survival in vitro, and tumor growth and metastasis in vivo.Here we characterize two anti-CDCP1 antibodies, focusing on immuno-conjugates of one of these as a tool to detect and inhibit ovarian cancer.Methods: A panel of ovarian cancer cell lines was examined for cell surface expression of CDCP1 and loss of expression induced by anti-CDCP1 antibodies 10D7 and 41-2 using flow cytometry and Western blot analysis.Surface plasmon resonance analysis and examination of truncation mutants was used to analyse the binding properties of the antibodies for CDCP1.Live-cell spinning-disk confocal microscopy of GFP-tagged CDCP1 was used to track internalization and intracellular trafficking of CDCP1/antibody complexes.In vivo, zirconium 89-labelled 10D7 was detected by positron-emission tomography imaging, of an ovarian cancer patient-derived xenograft grown intraperitoneally in mice.The efficacy of cytotoxin-conjugated 10D7 was examined against ovarian cancer cells in vitro and in vivo.Results: Our data indicate that each antibody binds with high affinity to the extracellular domain of CDCP1 causing rapid internalization of the receptor/antibody complex and degradation of CDCP1 via processes mediated by the kinase Src.Highlighting the potential clinical utility of CDCP1, positron-emission tomography imaging, using zirconium 89-labelled 10D7, was able to detect subcutaneous and intraperitoneal xenograft ovarian cancers in mice, including small (diameter <3 mm) tumor deposits of an ovarian cancer patient-derived xenograft grown intraperitoneally in mice.Furthermore, cytotoxin-conjugated 10D7 was effective at inhibiting growth of CDCP1-expressing ovarian cancer cells in vitro and in vivo.Conclusions: These data demonstrate that CDCP1 internalizing antibodies have potential for killing and detection of CDCP1 expressing ovarian cancer cells.
Evaluation of pulmonary tuberculosis diagnostic tests in children and adolescents at a pediatric reference center
Authors: Andrea M.O. Rossoni, Kathryn L. Lovero, Tonny T. Tahan, Antônio R. Netto, Marssoni D. Rossoni, Isabela N. Almeida, Elisangela A.S. Lizzi, Afranio Kritski, Cristina O. Rodrigues
Journal: Pulmonology (2020)

This study evaluates the performance of individual and combinations tests used for pediatric tuberculosis diagnosis at a reference center.Diagnostic test outcomes from children with presumed pulmonary tuberculosis evaluated from January 2005 - July 2010 were compared to a standard diagnosis made by an expert panel of physicians.Presence of at least one sign/symptom, history of contact, or abnormal chest X-ray (aCXR) individually showed the highest sensitivity (85.7%). While the combination of history of contact, at least one sign/symptom, positive tuberculin skin test, and aCXR had low sensitivity of 20%, but the specificity and a positive predictive value were 100%, respectively. The combination of tests used in the International Union Against Tuberculosis and Lung Disease and the Brazilian Ministry of Health systems showed sensitivity of 28.6% and 71.4% and specificity of 95.8% and 97.0%, respectively.In the absence of a gold standard, the combination of clinical history, tuberculin skin test, and aCXR, as well as the Brazilian scoring system serve as simple, low-cost approach that can be used for pediatric TB diagnosis by first-contact care providers.
PD-L1はHIF-1αの新規直接ターゲットであり,低酸素症下での遮断はMDSC媒介T細胞活性化を高めた
Authors: Noman Muhammad Zaeem, Desantis Giacomo, Janji Bassam, Hasmim Meriem, Karray Saoussen, Dessen Philippe, Bronte Vincenzo, Chouaib Salem
Journal: The Journal of Experimental Medicine (2014)
LRRTMs Organize Synapses through Differential Engagement of Neurexin and PTPσ
Authors: Reiko T. Roppongi, Shreya H. Dhume, Nirmala Padmanabhan, Prabhisha Silwal, Nazmeena Zahra, Benyamin Karimi, Claire Bomkamp, Chetan S. Patil, Kevin Champagne-Jorgensen, Rebecca E. Twilley, Peng Zhang, Michael F. Jackson, Tabrez J. Siddiqui
Journal: Neuron (2020)
Abnormal Dendritic Cell‐poiesis in Patients With Lower‐risk Myelodysplastic Syndromes
Authors: Ángela Sánchez, Eduardo Anguita, Alberto Chaparro, Juan José Roldán‐Etcheverry, Alberto López‐García, Carlos Ramos‐Acosta, Raluca Oancea, Diego Rodriguez‐Muñoz, Susana Alemany
Journal: HemaSphere (2020)

Supplemental Digital Content is available in the text
Malnutrition in Older Patients With Hematological Malignancies at Initial Diagnosis – Association With Impairments in Health Status, Systemic Inflammation and Adverse Outcome
Authors: Reinhard Stauder, Julia Augschoell, Marije E. Hamaker, Karin A. Koinig
Journal: HemaSphere (2020)

Supplemental Digital Content is available in the text
Dysphagia in a 34-Year-Old Woman
Authors: Shai Posner, Amanda Boyd, Amit Patel
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Trauma-Informed Care May Ease Patient Fear, Clinician Burnout
Authors: Bridget M. Kuehn
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Genotyping and Efficacy Outcomes: Exploratory Biomarker Data from the Phase II Abigail Study of 1st-Line Bevacizumab + Chemotherapy in Non-Squamous Non-Small-Cell Lung Cancer (NS-NSCLC)
Authors: C. Pallaud, M. Reck, E. Juhasz, B. Szima, C. Yu, O. Burdaeva, S. Orlov, S.J. Scherer, V. Archer, T.S.K. Mok
Journal: Annals of Oncology (2012)