AB0100 COMPARATIVE ANALYSIS OF THE EFFECTIVENESS AND TOLERANCE OF INTRA-ARTICULAR INJECTION OF PLATELET RICH PLASMA VS HYALURONIC ACID AND NON-ARTHROSCOPIC JOINT LAVAGE IN PATIENTSWITH KNEE OSTEOARTHRITIS
Authors: Rafaela Ortega Castro, Rocio Segura, Jerusalem Calvo Gutierrez, Rocio Espino-Garcia, María del Carmen Castro Villegas, Alejandro Escudero Contreras, Miguel A. Caracuel-Ruiz, Ladehesa Pineda Lourdes, Desiree Ruíz-Vilchez, Montserrat Romero-Gómez, Pilar Carreto-Font, Eduardo Collantes Estevez, Font Ugalde Pilar
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background:</h3> Knee Osteoarthritis (KOA) is a common condition associated with pain and morbidity. The impact of this pathology makes it necessary to develop new procedures for joint regeneration. Regenerative treatments such as platelet-rich plasma (PRP) are being proposed as a safe alternative, capable of regenerating damaged tissues and improving the quality of life, reducing the need to surgical procedures (1-4). <h3>Objectives:</h3> To compare the effectiveness of PRP treatment vs Hialuronic Acid (HA) and Non-Arthroscopic Joint Lavage (NAJL) in patients with KOA. <h3>Methods:</h3> It was performed a prospective, 3-months observational study of 51 patients with KOA, from the OA clinic of the Reina Sofía Hospital of Córdoba. Patients were treated according to clinical practice in 1 of the 3 treatment arms (PRP, HA, NAJL). Pain and disability were evaluated using Visual Analogue Scale (VAS) of joint pain, WOMAC and OARSI. We compared the baseline data using simple ANOVA and chi-squared tests and the intra- and inter-group differences before and after treatment (0, 1 and 3 months) using the mixed ANOVA test. All comparisons were bilateral considering p≤0.05 as a significant result. <h3>Results:</h3> 51 patients were enrolled, of which 52.9% were female. The average age (±SD) was 58.47 ± 7.48 years. The average Body Mass Index (BMI) was 30.64 ± 4.25 Kg/m<sup>2</sup>. Characteristics at baseline were comparable among the 3 treatment groups (Table 1). An overall improvement was observed during the follow-up in the PRP group in terms of pain and disability with respect to the baseline, with a VAS MD of -3.00 [95% CI, -4.79 to -1.21] in the first month and -3.08 [CI 95%, -4.79 to -1.38] at 3 months (p &lt;0.001), a MD WOMAC of -18.83 [95% CI, -30.62 to -7.05] (p = 0.001) in the first month, and a MD of OARSI of -19.32 [95% CI, -34.26 to -4.37], (p = 0.008) in the first month and -18.94 [95% CI, -36.81 to -1.07] at 3 months (p = 0.035). In addition, the PRP group was superior to the HA group, showing a significant improvement in the VAS at 1 and 3 months (p &lt;0.005) and compared to the NAJL group, PRP showed better results in the WOMAC throughout the follow-up (p &lt;0.01) and in the OARSI at 3 months (p = 0.013). <h3>Conclusion:</h3> Based on our results, the intra-articular infiltration with PRP could therefore constitute a safe and effective treatment option in KOA patients, with short-medium term results superior in terms of pain and disability to conventional treatment with HA and NALJ. <h3>Reference</h3> [1] Huang Y, et al. Orthopade. 2019 Jan 8. 2)Burke, et al. Clin trans Med (2016) 5-27. 3)Wroblewski AP, et al. Oper Tech Orthop 2010; 20: 98-105. 4) De La Mata J, et al. Reumatol Clínica. 2013; 9(3):166-71. <h3>Disclosure of Interests:</h3> Rafaela Ortega Castro: None declared, Rocio Segura: None declared, Jerusalem Calvo Gutierrez: None declared, Rocio Espino-Garcia: None declared, María del Carmen Castro Villegas Paid instructor for: MSD, Abbvie, Pfizer, Janssen, Lilly, Roche, Alejandro Escudero Contreras: None declared, Miguel A. Caracuel-Ruiz: None declared, Ladehesa Pineda Lourdes: None declared, Desiree Ruíz-Vilchez: None declared, Montserrat Romero-Gómez: None declared, Pilar Carreto-Font: None declared, Eduardo Collantes Estevez: None declared, Font Ugalde Pilar: None declared