tbuckley/cabot-search huggingface dataset:
Quality-Adjusted Time without Symptoms or Toxicity (Q-TWiST) Analysis of Quizartinib Vs Salvage Chemotherapy in Patients with Relapsed/Refractory (R/R) FLT3-ITD Acute Myeloid Leukemia (AML)
Authors: Jorge E. Cortes, Siddhartha Ganguly, Samer K. Khaled, Alwin Krämer, Mark J. Levis, Giovanni Martinelli, Alexander E. Perl, Nigel H. Russell, Marc Botteman, Ruchit Shah, Linlin Luo, Zhenming Shun, Saurabh Ray
Journal: Blood (2019)
Survival, surgical resectability, and late effects in the hepatoblastoma patients treated by cisplatin plus pirarubicin (CITA) chemotherapy.
Authors: Eiso Hiyama, Arata Kamimatsuse, Yoshiyuku Onitake, Yuka Ueda, Kenichiro Watanabe, Tomoro Hishiki, Tatsuro Tajiri, Kohmei Ida, Michihiro Yano, Satoshi Kondo, Takaharu Oue
Journal: Journal of Clinical Oncology (2013)

10038 Background: The Japanese Study Group for Pediatric Liver Tumor(JPLT) is running cooperative treatment studies on hepatoblastoma (HB) since 1991. The main aim in JPLT-2 study was to evaluate the efficacy of cisplatin/pirarubicin. JPLT-2 protocol was launched in 1999 to evaluate the cure rate of risk-stratified HB: standard risk HB (a tumor involving three or fewer sectors of the liver), intermediate risk HB (a tumor involving all sectors of the liver or invasion into portal or hepatic vein) and high risk HB (a tumor involving all sectors of the liver or with metastasis). Methods: Until 2011, 313 children with hepatic tumors who were younger than 15 years of age were eligible for inclusion in the JPLT2 study. The cisplatin/pirarubicin regimen (CITA) is kept as the first line in 254 cases. In this study, we examined the outcome and late effects of the HB patients by the risk-stratified three groups (standard, intermediate and high risk groups). Results: Until 2011, 254 cases underwent the CITA protocol including 78 cases (18%) with metastatic tumors. The 3-year OS of the cases with standard risk HB were 94%, while that of the cases with Intermediate and high risk HB was 64% and 34%, respectively. Except for23 cases who underwent primary resection, complete resection of primary after CITA was performed 86% of standard risk, 66% of intermediate risk and 56% of high risk patients. And the late phase complications were 4 cases with maldevelopment, 15 with cardiac complications, 24 with ototoxicity and 5 with second malignancies. Conclusions: As compared with other regimens, CITA regimens achieved similar or superior rates of survival and resectability in standard risk patients. More promising strategies including adequate liver transplantation and new targeting drugs should be developed for intermediate and high risk HBs. Clinical trial information: UMIN000001116.
New Insights in Mechanims Involved in Apoptosis Resistance in Acute Myeloid Leukemia.
Authors: Corine J. Hess, Johannes Berkhof, Fedor Denkers, Gert J. Ossenkoppele, Peter J. Valk, Ruud Delwel, Quinten Waisfisz, Gerrit Jan Schuurhuis
Journal: Blood (2005)
Secondary Malignancy after Allogeneic Stem Cell Transplantation: Incidence and Risk Factors.
Authors: Chitra Hosing, Rima M. Saliba, Marcos De Lima, Sergio Giralt, Shubhra Ghosh, Yvonne Hsu, Paolo Anderlini, Sharon R. Hymes, Borje Andersson, Issa F. Khouri, Richard Champlin, Daniel Couriel
Journal: Blood (2005)
Interleukin-15 (dys)regulation of lymphoid homeostasis: Implications for therapy of autoimmunity and cancer
Authors: Thomas A. Waldmann, Milos D. Miljkovic, Kevin C. Conlon
Journal: The Journal of Experimental Medicine (2019)

IL-15, a pleiotropic cytokine, stimulates generation of NK, NK-T, γδ, ILC1, and memory CD8 T cells. IL-15 disorders play pathogenetic roles in organ-specific autoimmune diseases including celiac disease. Diverse approaches are developed to block IL-15 action. IL-15 administered to patients with malignancy yielded dramatic increases in NK numbers and modest increases in CD8 T cells. Due to immunological checkpoints, to achieve major cancer therapeutic efficacy, IL-15 will be used in combination therapy, and combination trials with checkpoint inhibitors, with anti-CD40 to yield tumor-specific CD8 T cells, and with anticancer monoclonal antibodies to increase ADCC and antitumor efficacy, have been initiated.
Relationship between baseline white blood cell count and degree of coronary artery disease and mortality in patients with acute coronary syndromes
Authors: Marc S Sabatine, David A Morrow, Christopher P Cannon, Sabina A Murphy, Laura A Demopoulos, Peter M DiBattiste, Carolyn H McCabe, Eugene Braunwald, C.Michael Gibson
Journal: Journal of the American College of Cardiology (2002)
The Laboratory Domestication of Zebrafish: From Diverse Populations to Inbred Substrains
Authors: Jaanus Suurväli, Andrew R Whiteley, Yichen Zheng, Karim Gharbi, Maria Leptin, Thomas Wiehe
Journal: Molecular Biology and Evolution (2019)

We know from human genetic studies that practically all aspects of biology are strongly influenced by the genetic background, as reflected in the advent of "personalized medicine." Yet, with few exceptions, this is not taken into account when using laboratory populations as animal model systems for research in these fields. Laboratory strains of zebrafish (Danio rerio) are widely used for research in vertebrate developmental biology, behavior, and physiology, for modeling diseases, and for testing pharmaceutic compounds in vivo. However, all of these strains are derived from artificial bottleneck events and therefore are likely to represent only a fraction of the genetic diversity present within the species. Here, we use restriction site-associated DNA sequencing to genetically characterize wild populations of zebrafish from India, Nepal, and Bangladesh, and to compare them to previously published data on four common laboratory strains. We measured nucleotide diversity, heterozygosity, and allele frequency spectra, and find that wild zebrafish are much more diverse than laboratory strains. Further, in wild zebrafish, there is a clear signal of GC-biased gene conversion that is missing in laboratory strains. We also find that zebrafish populations in Nepal and Bangladesh are most distinct from all other strains studied, making them an attractive subject for future studies of zebrafish population genetics and molecular ecology. Finally, isolates of the same strains kept in different laboratories show a pattern of ongoing differentiation into genetically distinct substrains. Together, our findings broaden the basis for future genetic, physiological, pharmaceutic, and evolutionary studies in Danio rerio.
Hot off the press: downregulation of PRMT1 for long-lasting effects of bronchial thermoplasty
Authors: Siti Farah Rahmawati, Reinoud Gosens
Journal: European Respiratory Journal (2019)

Asthma is broadly defined as a group of clinical symptoms with reversible expiratory airflow limitation or bronchial hyperresponsiveness with or without airway inflammation [1]. These symptoms are associated with airway remodelling, particularly in severe asthma patients, which is characterised by alterations of the tissue structure and cells within the airway, including increased submucosal extracellular matrix deposition, reticular basement membrane (RBM) thickening, airway smooth muscle (ASM) hyperplasia and hypertrophy, bronchial microvascular remodelling and mucous cell metaplasia [2–4]. An epithelial–mesenchymal interaction governed by HSP60-regulated PRMT1 expression regulates airway remodelling and is reversed by bronchial thermoplasty <http://bit.ly/2NDCKGW>
The Clinical Efficacy of Helicobacter pylori Eradication in Patients with Helicobacter pylori-Positive Chronic Thrombocytopenic Purpura.
Authors: Seung-Hyun Nam, Bong-Seog Kim, Jae Hoon Lee, Hong Suk Song, Sung-Hwa Bae, Myung Soo Hyun, Young Jin Yuh, Sang-Jae Lee, Seonyang Park
Journal: Blood (2005)
Assessment of a Staging System for Sigmoid Colon Cancer Based on Tumor Deposits and Extramural Venous Invasion on Computed Tomography
Authors: Nigel D’Souza, Annabel Shaw, Amy Lord, Svetlana Balyasnikova, Muti Abulafi, Paris Tekkis, Gina Brown
Journal: JAMA Network Open (2019)

Preoperative TNM stratification of colon cancer on computed tomography (CT) does not identify patients who are at high risk of recurrence that could be selected for preoperative treatment.To evaluate the utility of CT findings for prognosis of sigmoid colon cancer.This prognostic study used retrospective data from patients who underwent bowel resection for sigmoid colon cancer between January 1, 2006, and January 1, 2015, at a tertiary care center receiving international and national referrals for colorectal cancer. Statistical analysis was performed in April 2019.Cox proportional hazards regression analysis was performed to investigate CT findings associated with disease recurrence. Kaplan-Meier survival plots were calculated for disease-free survival using CT staging systems.Of the 414 patients who had sigmoid colon cancer (248 [60.0%] men; mean [SD] age, 66.1 [12.7] years), with median follow-up of 61 months (interquartile range, 40-87 months), 122 patients (29.5%) developed disease recurrence. On multivariate analysis, nodal disease was not associated with disease recurrence; only tumor deposits (hazard ratio [HR], 1.90; 95% CI, 1.21-2.98; P = .006) and extramural venous invasion (HR, 1.97; 95% CI, 1.26-3.06; P = .003) on CT were associated with disease recurrence. Significant differences in disease-free survival were found using CT-T3 substage classification (HR, 1.88; 95% CI, 1.32-2.68) but not CT-TNM (HR, 1.55; 95% CI, 0.94-2.55). The presence of tumor deposits or extramural venous invasion on CT (HR, 2.45; 95% CI, 1.68-3.56) had the strongest association with poor outcome.In this study, T3 substaging and detection of tumor deposits or extramural venous invasion on preoperative CT scans of sigmoid colon cancer were prognostic factors for disease-free survival, whereas TNM and nodal staging on CT had no prognostic value. T3 substaging and detection of tumor deposits or extramural venous invasion of sigmoid colon cancer was superior to TNM on CT and could be used to preoperatively identify patients at high risk of recurrence.
Abstract 16588: Relationship Between Sleep Debt and Obesity in Older Women: Findings From the Women’s Health Study
Authors: Stephanie T Child, Eva M Durazo, Tiffany Powell-Wiley, Natalie Slopen, Aric Prather, Susan Redline, Alan Zaslavsky, Julie E Buring, David R Williams, Michelle A Albert
Journal: Circulation (2018)

Background: Obesity is increasingly prevalent in older women and is associated with heightened risk of cardiovascular disease (CVD) and Type II diabetes (diabetes). Sleep disturbance has been shown to affect weight through numerous mechanisms, including metabolic and hormone dysregulation and diet. However, whether sleep debt, a measure of sleep deficiency during the week compared to the weekend,is associated with greater risk of obesity among older women with and without diabetes is relatively unknown. Methods and Results: Among women participating in the Women’s Health Study (WHS) 2012-2013 follow-up stress cohort, we examined the relationship between sleep debt and obesity in 21,726 women without a history of cancer or CVD. Sleep debt was defined as the difference between self-reported total weekday and weekend sleep hours of ≥ 2 hours (dichotomizedas ‘yes’ = 1 or ‘no’ = 0). Mean age was 72.0 ±6.0 years, 23.1% of women reported a body mass index ≥30 kg/m 2 , and 9.9% of participants had diabetes. Sleep debt was reported by 6.5% of women. Compared to women without sleep debt, women with sleep debt were more likely to be less physically active and diabetic, and to report more cumulative psychological stress (e.g., a composite score of acute and chronic stressors including work, work-family spillover, financial, traumatic life events, negative life events, discrimination, relationship, and neighborhood). Logistic regression models revealed a positive association between sleep debt and obesity (OR=1.16, 95% CI: 1.02-1.33) after adjusting for age, race/ethnicity, education and income levels, physical activity, alcohol use, smoking history, and depression and anxiety symptoms (Table). However, this association does not remain significant after control for cumulative psychological stress. In analyses stratified by diabetes status, sleep debt is similarly associated with greater risk of obesity among non-diabetic women (OR=1.17, 95% CI: 1.02-1.36), however, this association does not remain significant once depression and anxiety symptoms and cumulative stress are added to the model. There was no association found between sleep debt and obesity among women with diabetes. Conclusion: Among older, non-diabetic women participating in the WHS, sleep debt was associated with greater risk of obesity.
Progressive Multifocal Leukoencephalopathy Associated with Rituximab Treatment of B-Cell Lymphoproliferative Disorders: A Report of 29 Cases from the RADAR Project.
Authors: Kenneth R. Carson, Andrew M. Evens, Steven T. Rosen, Jane N. Winter, Leo I. Gordon, Numa Gottardi-Littell, David Green, Charles L. Bennett
Journal: Blood (2007)
Phase 3 Efficacy Analysis of a Typhoid Conjugate Vaccine Trial in Nepal
Authors: Mila Shakya, Rachel Colin-Jones, Katherine Theiss-Nyland, Merryn Voysey, Dikshya Pant, Nicola Smith, Xinxue Liu, Susan Tonks, Olga Mazur, Yama G Farooq, Jenny Clarke, Jennifer Hill, Anup Adhikari, Sabina Dongol, Abhilasha Karkey, Binod Bajracharya, Sarah Kelly, Meeru Gurung, Stephen Baker, Kathleen M Neuzil, Shrijana Shrestha, Buddha Basnyat, Andrew J Pollard
Journal: New England Journal of Medicine (2019)

Salmonella Typhi is a major cause of fever in children in low- and middle-income countries. A typhoid conjugate vaccine (TCV) that was recently prequalified by the World Health Organization was shown to be efficacious in a human challenge model, but data from efficacy trials in areas where typhoid is endemic are lacking.
Outpatient Myeloablative Allogeneic Stem Cell Transplantion: A Comprehensive Approach Yields Decreased Hospital Utilization and Low Transplant Related Mortality.
Authors: Amy M. Barreras, Rebekah H. Matthews, Karen L. Manion, Kathy McNatt, Lawrence E. Morris, Asad Bashey, H. Kent Holland, Scott R. Solomon
Journal: Blood (2006)
Brain Banks Spur New Frontiers in Neuropsychiatric Research and Strategies for Analysis and Validation
Authors: Le Wang, Yan Xia, Yu Chen, Rujia Dai, Wenying Qiu, Qingtuan Meng, Liz Kuney, Chao Chen
Journal: Genomics Proteomics & Bioinformatics (2019)

Abstract Neuropsychiatric disorders affect hundreds of millions of patients and families worldwide. To decode the molecular framework of these diseases, many studies use human postmortem brain samples. These studies reveal brain-specific genetic and epigenetic patterns via high-throughput sequencing technologies. Identifying best practices for the collection of postmortem brain samples, analyzing such large amounts of sequencing data, and interpreting these results are critical to advance neuropsychiatry. We provide an overview of human brain banks worldwide, including progress in China, highlighting some well-known projects using human postmortem brain samples to understand molecular regulation in both normal brains and those with neuropsychiatric disorders. Finally, we discuss future research strategies, as well as state-of-the-art statistical and experimental methods that are drawn upon brain bank resources to improve our understanding of the agents of neuropsychiatric disorders.
Abstract P012: Cardiac Biomarkers of Newborn Myocardial Injury, Cardiomyopathy and Inflammation are Associated with Indicators of Premature Cardiovascular Disease in Childhood: The National Institutes of Health Project VIVA Study
Authors: Steven E Lipshultz, Tracie L Miller, James D Wilkinson, Diane R Gold, Emily Oken, Andrea Baccarelli, Christos S Mantzoros, Augusto A Litonjua, Nader Rifai, Sheryl L Rifas-Shiman, Steven D Colan, Mathew W Gillman
Journal: Circulation (2012)

Objective: To examine associations of cord blood cardiac biomarker levels in normal newborns with cardiovascular outcomes and adiposity in childhood. Methods: Among a sample (N=49) from 1120 Project Viva pediatric participants, selected to be ∼1/3 white, 1/3 black, 1/3 Hispanic, and whose gestational age at birth was ≥34 wks, we examined relations of cord blood levels of cardiac troponin T (cTnT, a biomarker for myocyte injury), high sensitivity C-reactive protein (hsCRP, a generalized marker of systemic inflammation) &amp; N-terminal pro-brain natriuretic peptide (NT-proBNP, a biomarker of LV pressure or volume overload, cardiomyopathy, cardiac neurohormonal activation) with child outcomes at ages 3 &amp; 7 years. Results: Forty six percent (22 of 49) were female. Mean cTnT was 47.0 pg/mL (range=15.1-87.3 pg/mL; detection limit=10 pg/ml). Mean NT-proBNP was 663 pg/mL (range=166-2042 pg/mL; normal &lt;150 pg/ml) and mean hsCRP was 0.07 mg/L (range=0.03-0.18 mg/L; normal &lt;1mg/L). For each 100 pg/mL increase in NT-pro-BNP, the ratio of subscapular: triceps skinfolds (central fat distribution) at 3 yrs was slightly higher (0.98 [95% CI -0.20, 2.16], P=0.10) and fat mass/m2 (DXA) at 7 yrs was higher (0.18 [95% CI 0.03, 0.33], P=0.02). For each 0.1 mg/L increase in hsCRP, the heart rate was 8.7 beats per minute lower (95% CI -15.8, -1.6, P=0.02) at age 7 years. Conclusions: Biomarkers of cardiomyopathy, inflammation, and cardiac injury are commonly elevated at birth. In this pilot study, cardiomyopathy and inflammation biomarkers were associated with higher central fat distribution and fat mass and lower resting pulse rate up to 7 years later. Larger cohort studies are needed to further examine cardio-metabolic outcomes related to these cord blood cardiac biomarkers.
Electron Microscope Studies on the Cardiac Conduction System of the Dog : II.THE SINOATRIAL AND ATRIOVENTRICULAR NODES
Authors: Keishiro Kawamura
Journal: Circulation (1961)

By careful microscopic identification, sections from the S-A and A-V nodes in the dog were selected for electron microscopy. The main portion of each node appears to be characterized by a complicated arrangement of small, irregularly shaped muscle cells and the presence of abundant nerve elements in the interstitium. The nodal cells, joining by apposition of the respective plasma membranes, tend to be arranged in a few rows and sometimes may give the appearance of an agglomerate of a number of cells. The myofibrils, being rather scanty and variable in direction in the sarcoplasm, terminate at the cell junction apparently in the same manner as in other heart muscle cells. Besides abundant sarcosomes, a considerable number of profiles of the sarcoplasmic reticulum can be seen in the sarcoplasm, some being associated with small dense granules. Occasionally a Golgi apparatus is seen in the peri-nuclear sarcoplasm. Nuclei in the nodal cells often appear to be large in relation to the size of the cells. Besides numerous non-myelinated nerve fibers, some profiles of myelinated fibers are also seen in the nodal regions. Although a number of axons, which are wholly or partially enveloped by Schwann cells and contain numerous small vesicles, may lie very closely to the muscle cells, no evidence has yet been shown of any connection corre-sponding to the neuromuscular junction in other muscle types. The intrinsic ganglion cells located close to the A-V node also contain Nissl bodies, agranular reticulum, mitochondria, and dense bodies in the perikaryon. The nodal artery in the S-A region was also studied with the electron microscope.
Abstract 14820: Association of the Orthodema Score and Invasively Measured Hemodynamics in Acute Decompensated Heart Failure
Authors: Wally Omar, David Pham, Mark H Drazner, Lynne W Stevenson, Jennifer T Thibodeau, W.H. Tang, Anu Lala, Justin L Grodin
Journal: Circulation (2018)

Introduction: The orthodema score (ODS) is a simple score rating the degree of congestion in acute decompensated heart failure (ADHF) that is associated with clinical outcomes. We sought, to determ...
Association Between Spending and Outcomes for Patients With Cancer
Authors: Meng Li, Darius N. Lakdawalla, Dana P. Goldman
Journal: Journal of Clinical Oncology (2019)

Article Tools REVIEW ARTICLES Health Services and Outcomes Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.19.01451 Journal of Clinical Oncology - published online before print December 5, 2019 PMID: 31804868 Association Between Spending and Outcomes for Patients With Cancer Meng Li, ScM, PhD1,2xMeng LiSearch for articles by this author; Darius N. Lakdawalla, PhD1,2,3xDarius N. LakdawallaSearch for articles by this author; and Dana P. Goldman, PhD1,2,3xDana P. GoldmanSearch for articles by this author Show More 1Leonard D. Schaeffer Center for Health Policy and Economics, University of Southern California, Los Angeles, CA2Sol Price School of Public Policy, University of Southern California, Los Angeles, CA3School of Pharmacy, University of Southern California, Los Angeles, CA https://doi.org/10.1200/JCO.19.01451 First Page Full Text PDF Figures and Tables © 2019 by American Society of Clinical Oncology
Abstract 14902: Inhibiting Lipoprotein(A)-Induced Endothelial Metabolic Changes Reverses Inflammation and Monocyte Transendothelial Migration
Authors: Jeffrey Kroon, Johan G Schnitzler, Renate M Hoogeveen, Miranda Versloot, Julian C Bachmann, Erik S Stroes
Journal: Circulation (2018)

Introduction: Elevated lipoprotein(a) [Lp(a)] has emerged as a highly prevalent, independent factor causing both a systemic pro-inflammatory state and eventually a markedly elevated risk for cardio...