tbuckley/cabot-search huggingface dataset:
Abstract 11552: The α5β1 Integrin Mediates Insulin-like Growth Factor-1 Induction of Aortic Smooth Muscle Alpha-Actin Expression Through a PI3K/mTORC2/eIF4E Translational Mechanism
Authors: Christopher Blackstock, Yusuke Higashi, Sergiy Sukhanov, Patrice Delafontaine
Journal: Circulation (2015)

In arterial remodeling, smooth muscle cell (SMC) loss of contractile phenotype and increased proliferation may result in vessel stenosis or a greater propensity for aneurysm formation and rupture. Here, we show that insulin-like growth factor-1 (IGF-1) induces contractile phenotype of human aortic SMCs in culture, and we investigate the signal transduction mechanisms responsible using Western blot. IGF-1 induced a dose-dependent increase in protein expression of the contractile marker alpha-actin (αSMA) (2.4-fold-increase, 18hr serum-free vs. 100ng/mL IGF-1, p&lt;0.001), without affecting ACTA2 mRNA levels (real time RT-PCR, 4-18 hrs, p=NS). Moreover, IGF-1 upregulation of αSMA expression was not blocked by actinomycin D but was inhibited by cycloheximide (p&lt;0.01), thereby demonstrating posttranscriptional and translation-dependent regulation by IGF-1, respectively. Furthermore, IGF-1-induced αSMA expression was not blocked with PD98059 or rapamycin (50 or 100 nM), but was completely inhibited with LY294002 (p&lt;0.001), 500 nM rapamycin (p&lt;0.01), and Torin 1, thereby indicating that the ability of IGF-1 to induce SMC differentiation was independent of Erk1/2 and mTORC1, but dependent on PI3K- and mTORC2-signaling. A prolyl-hydroxylase-inhibitor (EDHB) or a function-blocking antibody against the α2β1 integrin (BHA2.1) had no effect on IGF-1-upregulation of αSMA expression. However, both EDHB and BHA2.1 significantly attenuated IGF-1-induced expression of the proliferation marker PCNA, thereby suggesting that collagen and the α2β1 integrin promote IGF-1-induced proliferation. Conversely, a blocking antibody against the α5β1 integrin (JBS5) did not block IGF-1-induced PCNA expression but completely inhibited IGF-1 induction of αSMA expression (p&lt;0.01) and abolished IGF-1-induced phosphorylation of a master regulator of cap-dependent protein translation, eukaryotic initiation factor-4E (eIF4E) (p&lt;0.001). Therefore, we concluded that IGF-1 induced αSMA expression via a PI3K/mTORC2/eIF4E translational mechanism that is dependent on the α5β1 integrin. Overall, these findings provide evidence that the α5β1 and α2β1 integrins mediate IGF-1-signaling to govern IGF-1-induced translational regulation of SMC phenotype.
Abstract 20581: Renin Angiotensin Aldosterone System Genotype in Adults Late After Fontan Palliation
Authors: Luke J Burchill, Andrew N Redington, Candice K Silversides, Heather J Ross, Seema Mital, Laura Jimenez-Juan, Erwin N Oechslin, Cameron Slorach, Luc Mertens, Rachel M Wald
Journal: Circulation (2014)

Introduction: Adults with single ventricle physiology palliated with a Fontan circulation experience high morbidity and mortality due to circulatory failure. Renin-angiotensin-aldosterone (RAAS) ge...
Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent <i>Clostridioides difficile</i> infection
Authors: Benjamin H Mullish, Julie A K McDonald, Alexandros Pechlivanis, Jessica R Allegretti, Dina Kao, Grace F Barker, Diya Kapila, Elaine O Petrof, Susan A Joyce, Cormac G M Gahan, Izabela Glegola-Madejska, Horace R T Williams, Elaine Holmes, Thomas B Clarke, Mark R Thursz, Julian R Marchesi
Journal: Gut (2019)

Objective Faecal microbiota transplant (FMT) effectively treats recurrent Clostridioides difficile infection (rCDI), but its mechanisms of action remain poorly defined. Certain bile acids affect C. difficile germination or vegetative growth. We hypothesised that loss of gut microbiota-derived bile salt hydrolases (BSHs) predisposes to CDI by perturbing gut bile metabolism, and that BSH restitution is a key mediator of FMT’s efficacy in treating the condition. Design Using stool collected from patients and donors pre-FMT/post-FMT for rCDI, we performed 16S rRNA gene sequencing, ultra performance liquid chromatography mass spectrometry (UPLC-MS) bile acid profiling, BSH activity measurement, and qPCR of bsh / bai CD genes involved in bile metabolism. Human data were validated in C. difficile batch cultures and a C57BL/6 mouse model of rCDI. Results From metataxonomics, pre-FMT stool demonstrated a reduced proportion of BSH-producing bacterial species compared with donors/post-FMT. Pre-FMT stool was enriched in taurocholic acid (TCA, a potent C. difficile germinant); TCA levels negatively correlated with key bacterial genera containing BSH-producing organisms. Post-FMT samples demonstrated recovered BSH activity and bsh / bai CD gene copy number compared with pretreatment (p&lt;0.05). In batch cultures, supernatant from engineered bsh -expressing E. coli and naturally BSH-producing organisms ( Bacteroides ovatus, Collinsella aerofaciens, Bacteroides vulgatus and Blautia obeum ) reduced TCA-mediated C. difficile germination relative to culture supernatant of wild-type (BSH-negative) E. coli. C. difficile total viable counts were ~70% reduced in an rCDI mouse model after administration of E. coli expressing highly active BSH relative to mice administered BSH-negative E. coli (p&lt;0.05). Conclusion Restoration of gut BSH functionality contributes to the efficacy of FMT in treating rCDI.
Prognostic Value of Vasodilator Stress Cardiac Magnetic Resonance Imaging
Authors: John F. Heitner, Raymond J. Kim, Han W. Kim, Igor Klem, Dipan J. Shah, Dany Debs, Afshin Farzaneh-Far, Venkateshwar Polsani, Jiwon Kim, Jonathan Weinsaft, Chetan Shenoy, Andrew Hughes, Preston Cargile, Jean Ho, Robert O. Bonow, Elizabeth Jenista, Michele Parker, Robert M. Judd
Journal: JAMA Cardiology (2019)

Stress cardiac magnetic resonance imaging (CMR) is not widely used in current clinical practice, and its ability to predict patient mortality is unknown.
Self-assemble peptide biomaterials and their biomedical applications
Authors: Jun Chen, Xuenong Zou
Journal: Bioactive Materials (2019)

Inspired by self-assembling peptides found in native proteins, deliberately designed engineered peptides have shown outstanding biocompatibility, biodegradability, and extracellular matrix-mimicking microenvironments. Assembly of the peptides can be triggered by external stimuli, such as electrolytes, temperature, and pH. The formation of nanostructures and subsequent nanocomposite materials often occur under physiological conditions. The respective properties of side chains in each amino acids provide numerous sites for chemical modification and conjugation choices of the peptides, enabling various resulting supramolecular nanostructures and hydrogels with adjustable mechanical and physicochemical properties. Moreover, additional functionalities can be easily induced into the hydrogels, including shear-thinning, bioactivity, self-healing, and shape memory. It further broaden the scope of application of self-assemble peptide materials. This review outlines designs of self-assembly peptide (β-sheet, α-helix, collagen-like peptides, elastin-like polypeptides, and peptide amphiphiles) with potential additional functionalities and their biomedical applications in bioprinting, tissue engineering, and drug delivery.
Abstract 13992: The Impact of Dexmedetomidine on the Cardiac Electrophysiological Properties in Patients With Paroxysmal Atrial Fibrillation
Authors: Akinori Sairaku, Yukiko Nakano, Kazuyoshi Suenari, Yasuki Kihara
Journal: Circulation (2015)

Background: Dexmedetomidine (DEX), a selective α2-adrenergic receptor agonist, has increasingly been used as a sedative during ablation of atrial fibrillation. DEX is known to have some suppressive effects on the cardiac conduction system, however, that has not yet been extensively assessed in human adults. We aimed to perform a detailed analysis of the impact of DEX on the cardiac electrophysiological properties in patients with paroxysmal atrial fibrillation (AF). Methods and Results: We measured the cardiac electrophysiological properties in adult patients (65±11 years) undergoing ablation of paroxysmal AF who were assigned to receive DEX (10 minutes of a loading at a dose of 6μg/kg/min followed by a maintenance dose of 0.6μg/kg/min; N=120) or those who were assigned not to receive any sedative (N=120). The patients with DEX were more likely than those without to have a longer sinus cycle length (943±190 vs. 802±142ms; p&lt;0.001), greater corrected sinus node recovery time (547±334 vs. 441±239ms; p&lt;0.001), and more prolonged atrial effective refractory period (234±35 vs. 220±33ms; p&lt;0.001). The AH interval (103±24 vs. 91±20ms; p&lt;0.001), atrioventricular (AV) nodal effective refractory period (324±70 vs. 268±58ms; p&lt;0.001), and Wenckebach cycle length (446±76 vs. 377±55ms; p&lt;0.001) were greater in patients with DEX, while the HV interval was similar between the groups (42±11 vs. 41±8ms; p=0.63). AF was less often induced in the patients with DEX than in those without (8.3% vs. 20.8%; p=0.01), when a single extra stimulus was given within the atrial vulnerable period. Conclusions: DEX may have inhibitory effects on both the sinus node and AV node, and may even reduce the AF inducibility in adult AF patients.
Addiction 101, in Technicolor
Authors: Abigail Zuger
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Preliminary Data on Safety, Cellular Kinetics and Anti-Leukemic Activity of UCART19, an Allogeneic Anti-CD19 CAR T-Cell Product, in a Pool of Adult and Pediatric Patients with High-Risk CD19+ Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia
Authors: Reuben Benjamin, Charlotte Graham, Deborah Yallop, Agnieszka Jozwik, Oana Ciocarlie, Nitin Jain, Elias J. Jabbour, Marcela V. Maus, Matthiew Frigault, Nicolas Boissel, Jerome Larghero, Andre Baruchel, Mohamad Mohty, Barbara De Moerloose, Adrian Bloor, Noelle V. Frey, Amina Zinaï, Svetlana Balandraud, Anne Philippe, Sylvain Fouliard, Ludiane Gauthier, Jeanne Pauly, Cyril Konto, Candy Bermingham, Paul Veys, Waseem Qasim
Journal: Blood (2018)
Baseline Demographics Of Cow’s Milk Allergic Infants Recruited To A Randomised Controlled Trial Of Single-Dose Challenge With Cow’s Milk
Authors: Yvonne M. d'Art, Aideen M. Byrne, John Fitzsimons, Audrey DunnGalvin, Jonathan O'B. Hourihane
Journal: Journal of Allergy and Clinical Immunology (2019)
Ruxolitinib Combined with Etanercept for Patients with Corticosteroid-Refractory Acute Graft Versus Host Disease after Allogeneic Stem Cell Transplantation: A Multi-Center Prospective Study
Authors: Yanmin Zhao, Jimin Shi, Xiaoqing Li, Yi Luo, Yamin Tan, Xiaoyu Lai, Jian Yu, Jianping Lan, Wanmao Ni, Lieguang Chen, He Huang
Journal: Blood (2018)
Abstract 18821: Dysfunctional Regulatory T-Lymphocytes Promote Inflammation and Adverse Cardiac Remodeling in Chronic Ischemic Heart Failure
Authors: Shyam S Bansal, Mehak Goel, Mohamed Ameen Ismahil, Tariq Hamid, Hai Zhong, Yixin Wu, Sumanth D Prabhu
Journal: Circulation (2015)

The functional role of regulatory T-cells (Tregs) in chronic heart failure (HF) is unknown. Using flow cytometry, we assessed Tregs during the progression of ischemic HF in male C57Bl/6 mice after coronary ligation and myocardial infarction (MI). At 7 d post-MI, circulating Tregs (% CD4+ T-cells) were comparable to sham-operated mice. Thereafter, blood Tregs significantly (p &lt; 0.05 vs sham) increased ~1.5 fold at 2, 4, 6, and 8 w, and exhibited increased levels of pro-inflammatory intracellular IFNγ (40.5 ± 5.9 vs 28.4 ± 5.1%) and TNFα (34.6 ± 8.8 vs 21.7 ± 6.9%). Moreover, at 8 w post-MI, Tregs were increased in the spleen (24.1 ± 3.9 vs 18.3 ± 1.4%) and failing heart (0.95 ± 0.42 vs 0.33 ± 0.23%) as compared with sham mice. In contrast to splenic Tregs from sham mice, Tregs isolated from HF mice (8 w post-MI) failed to suppress effector T-cell proliferation, and were robustly antiangiogenic as indexed by mouse coronary endothelial cell tube formation assays. Transgenic mice expressing diphtheria toxin (DT) receptor (DTR) under control of the Foxp3 promoter underwent coronary ligation and DT-induced selective Treg ablation starting at 4 w post-MI (PBS control). Echocardiography before and after (8 w post-MI) PBS or DT injection revealed that in contrast to progressive LV dysfunction and remodeling after PBS, DT-mediated Treg ablation and subsequent reconstitution reversed pathological LV remodeling (decreased EDV and ESV, and increased EF). As compared with PBS injection, DT-induced Treg ablation also significantly (p &lt; 0.05) reduced LV hypertrophy; enhanced circulating CD34+Flk1+ cells, cardiac CCR5 gene expression, and myocardial capillary density; reduced border zone fibrosis; and decreased pro-inflammatory (IL-17, IL-2 and IL-6) and pro-fibrotic (IL-4 and IL-10) serum cytokines. Similar results were obtained upon Treg depletion with anti-CD25 antibody in HF. We conclude that Tregs in chronic HF acquire pathological pro-inflammatory, profibrotic, and antiangiogenic properties, and lose their immunosuppressive capacity. Dysfunctional Tregs promote inflammation and adverse LV remodeling in HF; depletion of dysfunctional Tregs and subsequent restoration to a normal Treg phenotype may represent a novel approach to therapeutic immunomodulation in HF.
Effective Immunomodulation with Pomalidomide Beginning at Early Lymphocyte Recovery during Induction Timed Sequential Therapy (TST) for Acute Myeloid Leukemia (AML) and High-Risk Myelodysplasia (HR-MDS)
Authors: Joshua F Zeidner, Hanna Knaus, Amer M. Zeidan, Amanda Blackford, Raul Montiel-Esparza, Gabrielle T. Prince, Lukasz P. Gondek, Gabriel Ghiaur, Margaret M. Showel, Amy E. DeZern, Keith W. Pratz, B. Douglas Smith, Mark J. Levis, Matthew C Foster, Catherine C. Coombs, Howard Streicher, Judith E. Karp, Leo Luznik, Ivana Gojo
Journal: Blood (2018)
Effect of pneumococcal conjugate vaccine introduction on childhood pneumonia mortality in Brazil: a retrospective observational study
Authors: Cynthia Schuck-Paim, Robert J Taylor, Wladimir J Alonso, Daniel M Weinberger, Lone Simonsen
Journal: The Lancet Global Health (2019)

Understanding the real-world effect of pneumococcal conjugate vaccines (PCVs) on pneumonia mortality is crucial because of the expectation that increased PCV use will substantially reduce the burden of pneumonia deaths in children younger than 5 years. However, few post-vaccine introduction studies have estimated the benefits of PCV use on childhood mortality and results have been inconsistent. Therefore, we set out to assess the effect of introduction of ten-valent pneumococcal conjugate vaccine (PCV10) on pneumonia mortality in children in Brazil.In this retrospective observational study, we used publicly available mortality data of children aged 3-59 months in Brazil. We separated data by age group (3-11 months, 3-23 months, and 3-59 months) and stratified data by three different socioeconomic factors of Brazilian municipalities (in 2010): Human Development Index, proportion of children living in extreme poverty, and proportion of mothers with no primary education. We first examined long-term trends in childhood pneumonia mortality in Brazil (from 1980 to 2014). We then assessed the effect of PCV10-introduced in Brazil in 2010-both nationally and in municipalities stratified by socioeconomic status, with a synthetic control approach as our primary analytical method.Between 1980 and 2010, a period during which Brazil's Human Development Index rose substantially, national pneumonia mortality in children younger than 5 years decreased from about 150 to 15 deaths per 100 000 children younger than 5 years. Despite rapid uptake of PCV10 after its introduction in 2010, we observed a further vaccine-associated decline of about 10% in national childhood pneumonia mortality with our primary analytical method, with a high degree of uncertainty in the estimates. We observed larger reductions in municipal childhood pneumonia mortality in all three age groups (3-11 months, 3-23 months, and 3-59 months) in municipalities with a high percentage of extreme childhood poverty and mothers with no primary education, with the largest decrease observed in children aged 3-23 months in municipalities with low maternal education (24%, 95% credible interval 7-35).The large reduction observed from 1980 to 2010 in national pneumonia mortality in children younger than 5 years underscores that improvements in nutrition, hygiene, education, and health care have an important role in reducing pneumonia mortality. Although the PCV-associated reduction in childhood pneumonia mortality at the national level was modest, we found that PCV led to larger reductions in low-income municipalities. Similarly, large benefits might occur when PCVs are introduced in other low-income settings.Bill & Melinda Gates Foundation and National Institute of Allergy and Infectious Diseases.
Comparison of phosphoproteomic profiles in left- and right-sided colorectal cancers.
Authors: Tineke Buffart, Robin Beekhof, Rosanne van den Oord, Richard R. de Haas, Thang V. Pham, Henk Dekker, Nicole C.T. van Grieken, Sander R. Piersma, Adriaan van den Brule, Peet Nooijen, Hans Pruijt, Connie R. Jiménez, Henk M.W. Verheul
Journal: Journal of Clinical Oncology (2019)

582 Background: Left- and right-sided colorectal cancers (CRCs) are different in terms of prognosis, treatment response and underlying molecular mechanisms. The aim of this study was to unravel the phosphoproteomic profiles of left- and right-sided primary CRCs and to identify potential drug targets for both primary tumor sites. Methods: In total phosphoproteomic profiles of 69 fresh-frozen biopsies, including 34 left-sided and 35 right-sided primary CRCs, were obtained by LC-MS/MS after cell lysis, digestion and phosphopeptide enrichment using anti-phosphotyrosine antibodies. MS/MS spectra were searched against a UniProt human reference proteome FASTA file using MaxQuant software. Fold changes between normalized intensities were calculated. Group comparison was performed using the R package Limma. P values below 0.01 and fold changes &gt; two were considered significant and biologically relevant. Results: In total 2,840 phosphopeptides were detected in at least 5% of the samples. Of these, 36 phosphopeptides were significantly upregulated and 14 were significantly downregulated in right-sided compared to left-sided CRCs using our stringent selection criteria. Since BRAF mutations and deficient DNA mismatch repair (dMMR) were more frequently observed in right-sided CRC (p &lt; 0.01), group comparison was repeated with MMR proficient CRCs only, resulting in 21 phosphopeptides up- and one downregulated in left- versus right-sided CRC. The identified phosphoproteins from the phosphopeptides included three FDA approved drug targets. Conclusions: Differences in phosphoproteomic profiles were detected between left- and right-sided CRCs, besides molecular differences such as BRAF mutation and MMR status. These results indicate that the molecular biology of left-and right-sided CRCs may explain their differences in clinical behavior and response to treatment.
Myeloid/Histiocytic Neoplasms Associated with Germ Cell Tumors Harbor Shared Genetic Abnormalities Indicating a Clonal Relationship, Unique Molecular Pathogenesis and Cellular Origin
Authors: Caleb Ho, Yanming Zhang, Umut Aypar, Mariko Yabe, Filiz Sen, Maria E Arcila, Ahmet Dogan, Kseniya Petrova-Drus
Journal: Blood (2018)
Stereotactic ablative radiotherapy versus standard radiotherapy in stage 1 non-small-cell lung cancer (TROG 09.02 CHISEL): a phase 3, open-label, randomised controlled trial
Authors: David Ball, G Tao Mai, Shalini Vinod, Scott Babington, Jeremy Ruben, Tomas Kron, Brent Chesson, Alan Herschtal, Marijana Vanevski, Angela Rezo, Christine Elder, Marketa Skala, Andrew Wirth, Greg Wheeler, Adeline Lim, Mark Shaw, Penelope Schofield, Louis Irving, Benjamin Solomon, Nick Nedev, Hien Le
Journal: The Lancet Oncology (2019)
Conceptual, statistical and clinical interpretation of results from: Cryosurgery combined with topical interventions for actinic keratosis: a systematic review and meta‐analysis
Authors: R. Jayaraj, C. Kumarasamy
Journal: British Journal of Dermatology (2019)

Linked Article: Heppt MV et al. Br J Dermatol 2019; 180:740–8.
Improved Real-Time Optical Diagnosis of Colorectal Polyps Following a Comprehensive Training Program
Authors: Jung Ho Bae, Changhyun Lee, Hae Yeon Kang, Min-Sun Kwak, Eun Young Doo, Ji Yeon Seo, Ji Hyun Song, Sun Young Yang, Jong In Yang, Seon Hee Lim, Jeong Yoon Yim, Joo Hyun Lim, Goh Eun Chung, Su Jin Chung, Eun Hyo Jin, Boram Park, Joo Sung Kim
Journal: Clinical Gastroenterology and Hepatology (2019)
Abstract 13580: Cardiac Atrial Appendage Stem Cells Preserve Cardiac Function in a Minipig Acute Myocardial Infarction Model
Authors: Yanick Fanton, Boris Robic, Annick Daniëls, Severina Windmolders, Leen Willems, Luc Jamaer, Jasperina Dubois, Eric Bijnens, Nic Heuts, kristof Notelaers, Rik Paesen, Marcel Ameloot, Urbain Mees, Jean-Luc Rummens, Marc Hendrikx, Karen Hensen, Remco Koninckx
Journal: Circulation (2013)

We assessed the hypothesis that cardiac function following acute myocardial infarction (MI) in the minipig model is preserved by autologous transplantation of the recently described cardiac atrial ...
Predictors Of BAT Positivity In Chronic Spontaneous Urticaria And Clinical Characteristics Of Patients
Authors: João Luís Alves Marcelino, Celia Costa, Pedro Aguiar, Marta Neto, Fátima Cabral Duarte, Sara Silva, Anabela Lopes, Ruben Ferreira, Tatiana Lourenco, Manuel P. Barbosa, Maria Conceição Pereira Santos
Journal: Journal of Allergy and Clinical Immunology (2019)
Sequential Combination of Low-Intensity Chemotherapy (Mini-hyper-CVD) Plus Inotuzumab Ozogamicin with or without Blinatumomab in Patients with Relapsed/Refractory Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia (ALL): A Phase 2 Trial
Authors: Koji Sasaki, Hagop M. Kantarjian, Farhad Ravandi, Nicholas J Short, Partow Kebriaei, Xuelin Huang, Michael E. Rytting, Nitin Jain, Marina Y. Konopleva, Guillermo Garcia-Manero, Richard E Champlin, Tapan M. Kadia, Jorge E. Cortes, Zeev E. Estrov, Koichi Takahashi, Morgan Mace, Maria Khouri, Patrice Nasnas, Jovitta Jacob, Rebecca E. Garris, Elias J. Jabbour
Journal: Blood (2018)
Abstract 18112: The Association Between Diabetes Status and Survival Following an Out-of-Hospital Cardiac Arrest: A Retrospective Cohort Study
Authors: Kyle Danielson, Sarah Brennenstuhl, Ian R Drennan, Laurie J Morrison, Monica Parry
Journal: Circulation (2016)

Background: Sudden cardiac arrest (SCA), confirmed absence of cardiac mechanical activity, is the leading cause of heart-related death in the US. Diabetes is associated with autonomic dysfunction (...