tbuckley/cabot-search huggingface dataset:
Neutrophil infiltration and whole-cell vaccine elicited by N-dihydrogalactochitosan combined with NIR phototherapy to enhance antitumor immune response and T cell immune memory
Authors: Shuhong Qi, Lisen Lu, Feifan Zhou, Yuzhou Chen, Mengli Xu, Lu Chen, Xiang Yu, Wei R. Chen, Zhihong Zhang
Journal: Theranostics (2020)

Melanoma is one of the deadliest malignancies with a high risk of relapse and metastasis.Long-term, tumor-specific, and systemic immunity induced by local intervention is ideal for personalized cancer therapy.Laser immunotherapy (LIT), a combination of local irradiation of laser and local administration of an immunostimulant, was developed to achieve such an immunity.Although LIT showed promising efficacy on tumors, its immunological mechanism is still not understood, especially its spatio-temporal dynamics.Methods: In this study, we investigated LIT-induced immunological responses using a 980-nm laser and a novel immunostimulant, N-dihydrogalactochitosan (GC).Then we followed the functions of key immune cells spatially and temporally using intravital imaging and immunological assays.Results: Immediately after LIT, GC induced a rapid infiltration of neutrophils which ingested most GC in tumors.The cytokines released to the serum peaked at 12 h after LIT.Laser irradiations produced photothermal effects to ablate the tumor, release damage-associated molecular patterns, and generate whole-cell tumor vaccines.LIT-treated tumor-bearing mice efficiently resisted the rechallenged tumor and prevented lung metastasis.Intravital imaging of tumor at rechallenging sites in LIT-treated mice revealed that the infiltration of tumor-infiltrating lymphocytes (TILs) increased with highly active motility.Half of TILs with arrest and confined movements indicated that they had long-time interactions with tumor cells.Furthermore, LIT has synergistic effect with checkpoint blockade to improve antitumor efficacy.Conclusion: Our research revealed the important role of LIT-induced neutrophil infiltration on the in situ whole-cell vaccine-elicited antitumor immune response and long-term T cell immune memory.
Methotrexate for the Treatment of Recalcitrant Erosive Lichen Planus of the Vulva
Authors: Abigail Cline, Adrian Cuellar-Barboza, Joseph L. Jorizzo, Rita O. Pichardo
Journal: JAMA Dermatology (2020)

Methotrexate for the Treatment of Recalcitrant Erosive Lichen Planus of the VulvaErosive lichen planus of the vulva (ELPV) is a subtype of lichen planus characterized by desquamative, erosive dermatitis involving the vulva and vagina.Management of ELPV is challenging; almost 25% of patients have ELPV that is resistant to first-line therapy with topical corticosteroids. 1,2There are very few studies of ELPV, which makes management of recalcitrant ELPV difficult.Specifically, little evidence is available on methotrexate (MTX) for the treatment of recalcitrant ELPV.The aim of this study was to retrospectively review medical records to evaluate the efficacy of treatment with MTX in women with ELPV at a vulvar clinic.
Professional Dissonance and Burnout in Primary Care
Authors: Sumit D. Agarwal, Erika Pabo, Ronen Rozenblum, Karen M. Sherritt
Journal: JAMA Internal Medicine (2020)

Burnout negatively affects physician health, productivity, and patient care. Its prevalence is high among physicians, especially those in primary care, yet few qualitative studies of burnout have been performed that engage frontline primary care practitioners (PCPs) for their perspectives.To identify factors contributing to burnout and low professional fulfillment, as well as potential solutions, by eliciting the views of PCPs.For this qualitative study, focus group discussions and interviews were conducted between February 1 and April 30, 2018, among 26 PCPs (physicians, nurse practitioners, and physician assistants) at a US academic medical center with a network of 15 primary care clinics. Participants were asked about factors contributing to burnout and barriers to professional fulfillment as well as potential solutions related to workplace culture and efficiency, work-life balance, and resilience.Perceptions of the factors contributing to burnout and low professional fulfillment as well as potential solutions.A total of 26 PCPs (21 physicians, 3 nurse practitioners, and 2 physician assistants; 21 [81%] women) from 10 primary care clinics participated. They had a mean (SD) of 19.4 (9.5) years of clinical experience. Six common themes emerged from PCPs' experiences with burnout: 3 external contributing factors and 3 internal manifestations. Participants described their workloads as excessively heavy, increasingly involving less "doctor" work and more "office" work, and reflecting unreasonable expectations. They felt demoralized by work conditions, undervalued by local institutions and the health care system, and conflicted in their daily work. Participants conveyed a sense of professional dissonance, or discomfort from working in a system that seems to hold values counter to their values as clinicians. They suggested potential solutions clustered around 8 themes: managing the workload, caring for PCPs as multidimensional human beings, disconnecting from work, recalibrating expectations and reimbursement levels, promoting PCPs' voice, supporting professionalism, fostering community, and advocating reforms beyond the institution.In sharing their perspectives on factors contributing to burnout, frontline PCPs interviewed during this study described dissonance between their professional values and the realities of primary care practice, an authority-responsibility mismatch, and a sense of undervaluation. Practitioners also identified possible solutions institutions might consider investing in to resolve professional dissonance, reduce burnout rates, and improve professional fulfillment.
m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination
Authors: Huan Xu, Yulia Dzhashiashvili, Ankeeta Shah, Rejani B. Kunjamma, Yi-lan Weng, Benayahu Elbaz, Qili Fei, Joshua S. Jones, Yang I. Li, Xiaoxi Zhuang, Guo-li Ming, Chuan He, Brian Popko
Journal: Neuron (2019)
Clinical Significance and Outcomes in Trial of Nabiximols for Treatment of Cannabis Dependence
Authors: Frances R. Levin, John J. Mariani
Journal: JAMA Internal Medicine (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
The cost of treatment-related adverse events in metastatic breast cancer therapy: Taxanes versus capecitabine.
Authors: Ryan N Hansen, Melissa G. Brammer, Scott David Ramsey, Deepa Lalla, Sara A. Hurvitz, Sean D Sullivan
Journal: Journal of Clinical Oncology (2013)

e17527 Background: Over 73,000 women annually experience new or recurrent metastatic breast cancer (mBC) in the U.S. Chemotherapy can prolong survival with mBC but adverse events (AEs) from chemotherapy are common, costly to manage and may lead to changes in clinical outcomes. We evaluated the difference in cost of treatment for taxane- (TAX) and capecitabine-based (CAP) treatments for mBC patients in the U.S. focusing on the incremental impact of AEs on the cost of care. Methods: A cohort of mBC patients diagnosed from 2008-2011 was identified from the Truven Marketscan® Database. Patients were grouped into chemotherapy categories of either TAX (paclitaxel or docetaxel) or CAP using claims data. Common chemo-related AEs were identified by ICD-9 codes. Healthcare costs were tabulated from a payer perspective, adjusted to 2011 U.S. dollars. To control for selection bias, propensity scores for treatment selection were calculated using age, diagnosis, health plan type, and renal or hepatic insufficiency as predictors. Generalized linear models estimated the cost of treatment by medication type and the presence/absence of AEs. Results: From 52 million subjects, we identified 13,474 mBC patients that met inclusion criteria. We identified 11,902 patients treated with TAX and 1,572 treated with CAP. At least one AE was experienced by 69% (S.D. = 0.46) of TAX users and 56% (S.D. = 0.50) of CAP users. The most common AEs were infection (39%), neutropenia (27%), and anemia (20%) for TAX users. CAP users most commonly experienced infection (36%), anemia (11%), and dyspnea (11%). Average incremental monthly costs were $3,082 and $6,793 for TAX and CAP patients with an AE compared to those who did not experience an AE, respectively. Costs increased by $1,358 for patients with 1-2 AEs (p=0.0002), $2,433 for 3-4 AEs (p&lt;0.0001), and $5,294 for 5+ AEs (p&lt;0.0001). Conclusions: Among community-treated patients, AEs are common in women with mBC receiving TAX and CAP based chemotherapy regimens. Persons experiencing these AEs have substantially higher healthcare costs which increase with the number of AE’s reported. Better management of AEs may represent an opportunity to significantly reduce costs and improve outcomes for women with mBC.
Paragraph: a graph-based structural variant genotyper for short-read sequence data
Authors: Sai Chen, Peter Krusche, Egor Dolzhenko, Rachel M. Sherman, Roman Petrovski, Felix Schlesinger, Melanie Kirsche, David R. Bentley, Michael C. Schatz, Fritz J. Sedlazeck, Michael A. Eberle
Journal: Genome biology (2019)

Accurate detection and genotyping of structural variations (SVs) from short-read data is a long-standing area of development in genomics research and clinical sequencing pipelines. We introduce Paragraph, an accurate genotyper that models SVs using sequence graphs and SV annotations. We demonstrate the accuracy of Paragraph on whole-genome sequence data from three samples using long-read SV calls as the truth set, and then apply Paragraph at scale to a cohort of 100 short-read sequenced samples of diverse ancestry. Our analysis shows that Paragraph has better accuracy than other existing genotypers and can be applied to population-scale studies.
Contradictory iPledge Requirements Hinder Physician Practice and Patient Care—Reply
Authors: Elizabeth Tkachenko, Sean Singer, Arash Mostaghimi
Journal: JAMA Dermatology (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Urea removal strategies for dialysate regeneration in a wearable artificial kidney
Authors: Maaike K. van Gelder, Jacobus A.W. Jong, Laura Folkertsma, Yong Guo, Christian Blüchel, Marianne C. Verhaar, Mathieu Odijk, Cornelus F. Van Nostrum, Wim E. Hennink, Karin G.F. Gerritsen
Journal: Biomaterials (2020)

The availability of a wearable artificial kidney (WAK) that provides dialysis outside the hospital would be an important advancement for dialysis patients. The concept of a WAK is based on regeneration of a small volume of dialysate in a closed-loop. Removal of urea, the primary waste product of nitrogen metabolism, is the major challenge for the realization of a WAK since it is a molecule with low reactivity that is difficult to adsorb while it is the waste solute with the highest daily molar production. Currently, no efficient urea removal technology is available that allows for miniaturization of the WAK to a size and weight that is acceptable for patients to carry. Several urea removal strategies have been explored, including enzymatic hydrolysis by urease, electro-oxidation and sorbent systems. However, thus far, these methods have toxic side effects, limited removal capacity or slow removal kinetics. This review discusses different urea removal strategies for application in a wearable dialysis device, from both a chemical and a medical perspective.
Blood eosinophils relate to atopy and not to tissue eosinophils in wheezing children
Authors: Matteo Bonato, Erica Bazzan, Deborah Snijders, Graziella Turato, Davide Biondini, Mariaenrica Tinè, Manuel G. Cosio, Angelo Barbato, Marina Saetta, Simonetta Baraldo
Journal: Allergy (2020)

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Interpreting the Benefit of Simvastatin-Ezetimibe in Patients 75 Years or Older
Authors: Daniel Li, Zachary R. McCaw, Lee-Jen Wei
Journal: JAMA Cardiology (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Comparison between diameters of the whole nodule and solid area and the proportion of GGO in the tumor shadow on HRCT in predicting less-invasive lung cancer and recurrence after complete resection in patients with clinical N0 NSCLC.
Authors: Haruhisa Matsuguma, Rie Nakahara, Haruko Suzuki, Takashi Kasai, Yukari Kamiyama, Seiji Igarashi, Kiyoshi Mori, Tetsuro Kodama, Kohei Yokoi
Journal: Journal of Clinical Oncology (2012)

7021 Background: Prediction of less-invasive lung cancer is important in selecting candidates for limited surgical resection. A greater proportion of ground-glass opacity (%GGO) is well-known to be strongly associated with less-invasive lung adenocarcinoma. Recently, the diameter of the solid area (SolidØ) has been reported to also be a simple and better marker for the same purpose compared to the diameter of the whole nodule (NoduleØ). The aim of this study was to confirm that SolidØ can completely replace %GGO in predicting less-invasive lung cancer. Methods: From 1987 to 2009, 433 patients with clinical T1a-2bN0 NSCLC underwent complete resection, and their preoperative HRCT images were preserved in DICOM format. NoduleØ and SolidØ were precisely measured using software. %GGO was calculated using the method we previously published (Eur J Cardiothorac Surg 25:1102-6, 2004). Less-invasive lung cancer was defined as having no vascular, lymphatic, nor pleural invasion. We compared the three parameters with regard to predicting less-invasive lung cancer and recurrence. Results: Among the 433 patients, 220 were male, 367 had an adenocarcinoma histology, and 58 experienced recurrence. Table shows percentages and numbers of non-less-invasive lung cancer cases. Among each category of SolidØ, greater %GGO is associated with less-invasive lung cancer. ROC analysis also showed that the area under the curve of %GGO was the highest (0.859, 95% CI 0.824 – 0.893), followed by SolidØ (0.806, 0.767 – 0.846), and NoduleØ (0.671, 0.620 – 0.721). Regardless of SolidØ, no patient with a greater %GGO (&gt; 50%) experienced recurrence. Conclusions: Although SolidØ is a better prognostic indicator of non-invasiveness compared to NoduleØ, %GGO remains important. [Table: see text]
Aryl Hydrocarbon Receptor Modulation by Tuberculosis Drugs Impairs Host Defense and Treatment Outcomes
Authors: Andreas Puyskens, Anne Stinn, Michiel van der Vaart, Annika Kreuchwig, Jonas Protze, Gang Pei, Marion Klemm, Ute Guhlich-Bornhof, Robert Hurwitz, Gopinath Krishnamoorthy, Marcel Schaaf, Gerd Krause, Annemarie H. Meijer, Stefan H.E. Kaufmann, Pedro Moura-Alves
Journal: Cell Host & Microbe (2019)
Magnetic resonance energy transfer for in vivo glutathione susceptibility weighted imaging
Authors: Kun Wang, Huilin Zhang, Aijun Shen, Peiran Zhao, Xianfu Meng, Xiaoyan Chen, Yang Liu, Yanyan Liu, Teng Gong, Wanlu Wu, Xiangming Fang, Peijun Wang, Wenbo Bu
Journal: Biomaterials (2019)
Association Between Maternal Fluoride Exposure and Child IQ—Reply
Authors: Christine Till, Rivka Green, Bruce Lanphear
Journal: JAMA Pediatrics (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Twelve-Year Survival of a Patient With Lymph Node, Pulmonary, Bone, Cardiac and Intraspinal Metastases of a Rectal Neuroendocrine Neoplasm Treated With Peptide Receptor Radionuclide Therapy—The Value of Salvage Peptide Receptor Radionuclide Therapy
Authors: Jingjing Zhang, Harshad R. Kulkarni, Aviral Singh, Richard P. Baum
Journal: Clinical Nuclear Medicine (2019)

Abstract We report here the 12-year survival after the first peptide receptor radionuclide therapy (PRRT) of a patient with metastatic rectal neuroendocrine neoplasms, who received 7 cycles of PRRT with 177 Lu/ 90 Y-DOTATATE/DOTATOC in 4 treatment phases. The patient demonstrated excellent response to each cycle of treatment, without any adverse effect even after repeated PRRT cycles. Most recently, immunohistochemistry revealed a G3 neuroendocrine neoplasm and intraspinal metastasis were successfully resected by neurosurgical intervention. This case nicely demonstrates that several “salvage” PRRTs can be given over many years leading to repetitive benefit for the patient and saving patients of possible toxicity of alternative treatments.
A comparison of bronchofiberscopic (BFS) washing cytology (BWC) and formalin-fixed paraffin-embedded tissue (PPFE) in the analysis of EGFR mutations in advanced non-small cell lung cancer (NSCLC).
Authors: Naoya Hida, Yuuki Misumi, Yoko Agemi, Akira Sato, Mari Ishii, Tsuneo Shimokawa, Hiroaki Okamoto
Journal: Journal of Clinical Oncology (2013)

8054 Background: In the treatment of advanced NSCLC, EGFR mutation status is one of the most predictive factors for the efficacy of EGFR tyrosine kinase inhibitors, and the evaluation of EGFR mutation status using the PPFE has been widely used for this analysis throughout the world. However, whether BWC can be used as an alternative for PPFE in the analysis of EGFR mutations is unknown. The largest study evaluating these 2 methods included only around 20 samples. Therefore, in the current study, we compared the freeze stock solution of BWC with PPFE for the determination of EGFR mutation status in a large sample set. Methods: In diagnostic BFS examinations, after curetting or brushing and biopsy to target lesions, subsequent bronchial washing by saline was performed. Thereafter, the saline fluid in which the forceps were washed and the bronchial washing fluid were mixed in a sterilized tube and were immediately frozen in a -20°C freezer. EGFR mutation testing for both BWC and PPFE was performed using high-sensitivity PCR (BML, PCR-Invader). Results: A total of 440 BFS examinations were performed from Aug 2010 to Nov 2011 in our hospital. The BWCs of 268 suspected cases of lung cancer were successfully obtained. Of these, 51 cases that were pathologically confirmed as adenocarcinoma based on both BWC and PPFE were analyzed in this study. EGFR mutations were identified in 25 cases, while the remaining 26 cases had wild-type EGFR. In 49 of 51 cases, the results of EGFR mutation status were the same for BWC and PPFE, and the concordance rate was 96%. In one case, an exon-18 mutation was detected only by BWC. In another case an exon-21 mutation was detected only by PPFE. In 24 of 25 cases of EGFR mutation, the mutation site was the same in both samples. The kappa coefficient was 0.92. Conclusions: This is the largest genetic study to date demonstrating a head-to-head comparison of BWC and PPFE for the evaluation of EGFR mutations. Both methods showed high reliability and concordance using high-sensitivity PCR. BWC is considered a simple, rapid method and represents an effective alternative for PPFE in EGFR mutation testing.
Abstract 11102: Gb002, A Novel Inhaled Pdgfr Kinase Inhibitor, Demonstrates Efficacy in the Su5416 Hypoxia Rat Model of Pulmonary Arterial Hypertension (pah)
Authors: Anna Galkin, Bryan Clemons, Eduardo Garcia, Jennifer Brooks, Debbie Slee, Luisa Salter-Cid, Larry Zisman
Journal: Circulation (2019)

Introduction: Pulmonary arterial hypertension (PAH) is a progressive disorder characterized by excessive smooth muscle cell proliferation, vascular remodeling, increased pulmonary arterial pressure...