tbuckley/cabot-search huggingface dataset:
Abstract 14496: Association of Coronary Lipidic Plaque Burden With Impairment of Cholesterol Uptake Capacity, a Novel Indicator for HDL Functionality: OCT-based Observation Study
Authors: Toshihiko Oshita, Ryuji Toh, Yuichiro Nagano, Koji Kuroda, Yoshinori Nagasawa, Amane Harada, Katsuhiro Murakami, Maria Kiriyama, Keiko Yoshikawa, Keiko Miwa, Yasuhiro Irino, Hiromasa Otake, Toshiro Shinke, Tatsuro Ishida, Ken-ichi Hirata
Journal: Circulation (2017)

Background: Recent studies have shown that the capacity of high density lipoprotein (HDL) to stimulate cholesterol efflux from lipid-laden macrophages is a better predictor of cardiovascular diseas...
The mouth in inflammatory bowel disease and aspects of orofacial granulomatosis
Authors: Esther A. Hullah, Michael P. Escudier
Journal: Periodontology 2000 (2019)

Abstract Inflammatory bowel disease has a wide range of possible oral manifestations, many of which overlap with those seen in other conditions, including orofacial granulomatosis. The precise etiology remains unclear, as is the exact relationship between orofacial granulomatosis and Crohn's disease. Overall, there is growing evidence that orofacial granulomatosis and oral Crohn's disease are distinct clinical disorders with optimal management requiring a multidisciplinary approach with input from appropriate specialists in oral medicine, gastroenterology, allergy, dietetics, and clinical psychology. This review details the etiopathogenesis, clinical presentation, epidemiology, extra‐intestinal, and oral manifestations of inflammatory bowel disease and orofacial granulomatosis. It also assesses the current role of investigations in the diagnosis of orofacial granulomatosis and critically reviews the available evidence in relation to medical and surgical interventions for the condition, and its relationship to Crohn's disease.
SALINE-IMMERSION THERAPEUTIC ENDOSCOPY OF SPORADIC LATERALLY SPREADING NONAMPULLARY DUODENAL ADENOMAS
Authors: N Lazaridis, A Murino, N Koukias, A Telese, D Costa, R Raymond, EJ Despott
Journal: Endoscopy (2019)

Sporadic laterally spreading nonampullary duodenal adenomas (SLSNDA) are an uncommon incidental finding during oesophagogastroduodenoscopy. Endoscopic mucosal resection (EMR) in the duodenum is challenging due to increased risk of perforation and bleeding. Underwater EMR (UEMR) is a novel and effective endoscopic resection technique performed without submucosal injection. Saline-immersion therapeutic endoscopy (SITE) is an evolution of UEMR and saline solution is used instead of water to minimise the risk of water intoxication.
In the Trenches
Authors: Kristen Ann Ehrenberger
Journal: Annals of Internal Medicine (2019)

Ad Libitum21 May 2019In the TrenchesKristen Ann Ehrenberger, MD, PhDKristen Ann Ehrenberger, MD, PhDUniversity of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (K.A.E.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M18-2006 Audio Reading - “In the Trenches” Audio. Virginia Hood, MD, reads “In the Trenches” by Kristen Ann Ehrenberger, MD, PhD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Feel for the teenaged girl who cutsherself so she can control some-thing in a divided householdbut cannot bear the dozen pricksof the thin lidocaine needleso she will not feel any ofthe one hundred twenty stitchesneeded to lace her wrists back up.Sutures march like rows of barbed wireacross this no-man's land of skin.Her mother whispers in her hair,while her father stands guard, arms crossed,watching from the foot of the bed.My hand cramps around the forcepsas I bend down to sew again. Author, Article, and Disclosure InformationAffiliations: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (K.A.E.)Current Author Address: Kristen Ann Ehrenberger, MD, PhD; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement Audio Reading - “In the Trenches” Audio. Virginia Hood, MD, reads “In the Trenches” by Kristen Ann Ehrenberger, MD, PhD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 21 May 2019Volume 170, Issue 10Page: 731 ePublished: 21 May 2019 Issue Published: 21 May 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A Proposed System Toward Standardizing Surgical-Based Treatments for Malignant Pleural Mesothelioma, From the Joint National Cancer Institute–International Association for the Study of Lung Cancer–Mesothelioma Applied Research Foundation Taskforce
Authors: Joseph S. Friedberg, Melissa J. Culligan, Anne S. Tsao, Valerie Rusch, Boris Sepesi, Harvey I. Pass, Raphael Bueno, Bryan Burt, David J. Sugarbaker, Marc de Perrot, Alex A. Adjei, Prasad S. Adusumilli, Fred R. Hirsch, Shakuntala M. Malik, David J. Harpole
Journal: Journal of Thoracic Oncology (2019)
Évaluation de la procédure endoscopique TORE dans les échecs du Gastric Bypass. Protocole Apollo, résultats intermédiaires à 1 an
Authors: JC Valats, S Perretta, J Dargent, J Branche, G Pineton de Chambrun, P Blanc, D Nocca
Journal: Endoscopy (2019)

Le court-circuit gastrique ou Gastric Bypass (GBP) est une chirurgie bariatrique restrictive et malabsorptive consensuelle. La dilatation de la poche gastrique et de l'anastomose gastro-jéjunale, qui peut survenir à distance de l'intervention, diminue l'effet restrictif et peut entraîner une reprise pondérale à moyen ou long terme.
Anastomose choledoco-bulbaire sous écho-endoscopie par système Hot-AXIOS: étude multicentrique française d'évaluation de l'efficacité du système après apprentissage
Authors: J Jacques, F Fumex, J Privat, F Pinard, U Chaput, JC Valats, F Cholet, P Grandval, R Legros, J Jézéquel, H Lepetit, B Napoléon
Journal: Endoscopy (2019)

Le drainage biliaire sous écho-endoscopie est devenu l'alternative numéro 1 en cas d'échec ou d'impossibilité de CPRE pour les sténoses biliaires tumorales distales. Récemment nous avons évalué l'efficacité et la sécurité du système hot-AXIOS dans une étude multicentrique pilote incluant tous les centres ayant effectué au moins une pose l'année suivant sa commercialisation. Dans cette étude 11,5% des procédures étaient en échec. Le non suivi de la procédure recommandé (ponction directe de la voie biliaire avec le cystotome intégré + utilisation d'une prothèse dédiée (6 mm) + utilisation d'un courant de section pure) était le principal facteur de risque d'échec technique.
Reply
Authors: Young‐Sun Lee, Myung Han Hyun, Ji Hoon Kim, Jong Eun Yeon, Kwan Soo Byun
Journal: Hepatology (2019)

Supported by a National Research Foundation of Korea grant from the Korean government (Ministry of Education, Science and Technology, 2018R1A1A1A05076977). Potential conflict of interest: Nothing to report. We appreciate the comments by Mo et al. on our meta‐analysis.1 They mentioned three relevant points on the inherent limitations of the meta‐analysis. The first issue is the inclusion of studies that classified a single large tumor (>5 cm) as intermediate stage (B) in the Barcelona Clinic Liver Cancer (BCLC) system. According to the original BCLC classification and the recent clinical practice guideline from the European Association for the Study of the Liver, a single large hepatocellular carcinoma (HCC) is classified as early stage (BCLC‐A). However, there had been controversies about the heterogeneity of BCLC‐B, including whether a single large HCC should be classified as BCLC‐A or BCLC‐B. As most studies included in our analysis were performed under this uncertainty, seven studies classified a single large HCC as BCLC‐B. However, the treatment would not be changed whether a single large HCC belongs to BCLC‐A or BCLC‐B in real practice.2 Therefore, we decided to faithfully use the reported BCLC classification in the included trials if the BCLC stage was clearly demonstrated. The second issue about duplicated populations is also important. In our analysis, three studies used a common database that had partially overlapping patients.3 Therefore, theoretically, these patients should be investigated separately. However, those studies were performed in multiple centers with various inclusion criteria and enrollment periods, making it difficult to identify identical populations from the published data. Further, two studies conducted hierarchical analysis of the original database using propensity‐score matching.4 Compared with the other five studies that we excluded (Supporting Table S4),1 which were single‐center studies with completely overlapping data with other studies, we decided to include all three studies in our meta‐analysis to provide high‐level evidence for resolving the existing questions. Finally, Mo et al. pointed out that some studies possibly used data from historical comparisons rather than parallel comparisons. We concur about the inevitable limitation of meta‐analysis using retrospective studies. Nevertheless, we believe that our meta‐analysis provided essential evidence showing that surgical treatment could increase the overall survival of patients with intermediate‐stage to advanced‐stage HCC.
PERFORMANCE MEASURES IN IBD SURVEILLANCE COLONOSCOPY- IMPLEMENTING CHANGES TO PRACTICE IMPROVES PERFORMANCE
Authors: S Smith, R Cannatelli, N Sharma, A McCulloch, J Mak, UN Shivaji, T Iqbal, K Kane, S Ghosh, R Cooney, M Iacucci
Journal: Endoscopy (2019)

Currently dye-based chromoendoscopy (DCE) is recommended for Inflammatory Bowel Disease (IBD) surveillance. However DCE has not been widely adopted into clinical practice yet. We aimed to evaluate performance in IBD surveillance colonoscopy following introduction of structured changes in delivery of service.
L'offre de formation initiale en simulation en endoscopie digestive en France
Authors: M Camus, J Jacques, JP Le Mouel, JM Gonzalez, L Vuitton, M Pioche, JB Chevaux, A Culetto, A Berger, M Barret, G Vanbiervliet, M Palazzo, E Saillard, E Coron, M Barthet, X Dray, G Rahmi
Journal: Endoscopy (2019)

L'endoscopie digestive occupe une place centrale dans l'exercice de l'hépato-gastroentérologie (HGE). L'enseignement pratique de l'endoscopie comporte selon les recommandations: 1) une phase d'apprentissage sous le contrôle de tuteurs séniors dans les unités d'endoscopie des services agréés pour le DES d'HGE et 2) une phase d'apprentissage lors d'ateliers de simulation. Cette dernière se fait sur des simulateurs non organiques (simulateur de réalité virtuelle) ou organiques (modèles animaux). Il nous ait apparu une hétérogénéité territoriale concernant ces ateliers de simulation en endoscopie suite à notre expérience vécue d'enseignants, au retour des internes (sondage national via l'association des internes d'HGE), et de discussions avec nos collègues des différentes inter-régions.
Abstract PR01: Oncogenic Kras-induced mitochondrial oxidative stress in pancreatic acini modulates the formation of precancerous lesions through autocrine EGFR signaling
Authors: Geou-Yarh Liou, Heike Doeppler, Kathleen E. DelGirono, Howard C. Crawford, Michael P. Murphy, Peter Storz
Journal: Cancer Research (2016)

Abstract The development of pancreatic cancer requires both obtain of oncogenic Kras mutations and up-regulation of growth factor signaling. However, how oncogenic Kras regulates growth factor signaling in pancreatic cancer development is still unclear. Using a transgenic mouse model harboring an oncogenic Kras mutation and a 3D organoid explant culture of primary pancreatic acini, we here show that expression of mutant Kras in pancreatic acinar cells alters their mitochondrial metabolism, resulting in increased generation of mitochondrial reactive oxygen species (mROS). We further demonstrate that mROS induced by oncogenic Kras is required for transdifferentiating acinar cells to a duct-like phenotype and eventually progression to pancreatic intraepithelial neoplasia (PanIN), the most common precursor lesions of pancreatic ductal adenocarcinoma (PDAC). This transdiffentiation process is mediated by increased levels of epidermal growth factor receptor (EGFR) as well as its ligands, EGF and TGFα, through activation of the ROS-receptive transcription factors, NF-κB1 and NF-κB2. In Kas transgenic mice, the interception of KrasG12D-mediated generation of mROS significantly reduced the formation of pre-neoplastic lesions. Hence, our data provide mechanistic insight of how oncogenic Kras mutant crosstalks with growth factor signaling to cause the formation of pancreatic cancer. Citation Format: Geou-Yarh Liou, Heike Doeppler, Kathleen E. DelGirono, Howard C. Crawford, Michael P. Murphy, Peter Storz. Oncogenic Kras-induced mitochondrial oxidative stress in pancreatic acini modulates the formation of precancerous lesions through autocrine EGFR signaling. [abstract]. In: Proceedings of the Fourth AACR International Conference on Frontiers in Basic Cancer Research; 2015 Oct 23-26; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2016;76(3 Suppl):Abstract nr PR01.
Improving the Delivery of Common Medical Procedures to Achieve Value-Based Care
Authors: Andrew M. Ibrahim, Sameer D. Saini
Journal: JAMA Internal Medicine (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Abstract 10847: Neural Cell Adhesion Molecule is a Cardioprotective Factor Up-regulated In Rodent and Human Failing Heart
Authors: Kazuya Nagao, Koh Ono, Yohei Yamauchi, Motoko Tokunaga, Kohei Fukuchi, Koji Uchiyama, Haruyasu Ito, Fujio Hayashi, Toshinori Makita, Tsukasa Inada, Masaru Tanaka, Takahiro Horie, Hitoo Nishi, Minako Kinoshita, Yasuhide Kuwabara, Katsumi Inoue, Takeshi Kimura
Journal: Circulation (2012)

Purpose: Failing heart is characterized by alteration in energy metabolism, including mitochondrial dysfunction. While, membrane proteins have been a considerable interest because these proteins ha...
A Population-Based Study of Morbidity After Pancreatic Cancer Diagnosis
Authors: Reith R. Sarkar, Katherine E. Fero, Daniel M. Seible, Neil Panjwani, Rayna K. Matsuno, James D. Murphy
Journal: Journal of the National Comprehensive Cancer Network (2019)

Background: Pancreatic cancer is an aggressive disease characterized by early and relentless tumor spread, thus leading healthcare providers to consider it a “distant disease.” However, local pancreatic tumor progression can lead to substantial morbidity. This study defines the long-term morbidity from local and nonlocal disease progression in a large population-based cohort. Methods: A total of 21,500 Medicare beneficiaries diagnosed with pancreatic cancer in 2000 through 2011 were identified. Hospitalizations were attributed to complications of either local disease (eg, biliary disorder, upper gastrointestinal ulcer/bleed, pain, pancreas-related, radiation toxicity) or nonlocal/distant disease (eg, thromboembolic events, cytopenia, dehydration, nausea/vomiting/motility problem, malnutrition and cachexia, ascites, pathologic fracture, and chemotherapy-related toxicity). Competing risk analyses were used to identify predictors of hospitalization. Results: Of the total cohort, 9,347 patients (43.5%) were hospitalized for a local complication and 13,101 patients (60.9%) for a nonlocal complication. After adjusting for the competing risk of death, the 12-month cumulative incidence of hospitalization from local complications was highest in patients with unresectable disease (53.1%), followed by resectable (39.5%) and metastatic disease (33.7%) at diagnosis. For nonlocal complications, the 12-month cumulative incidence was highest in patients with metastatic disease (57.0%), followed by unresectable (56.8%) and resectable disease (42.8%) at diagnosis. Multivariable analysis demonstrated several predictors of hospitalization for local and nonlocal complications, including age, race/ethnicity, location of residence, disease stage, tumor size, and diagnosis year. Radiation and chemotherapy had minimal impact on the risk of hospitalization. Conclusions: Despite the widely known predilection of nonlocal/distant disease spread in pancreatic cancer, local tumor progression also leads to substantial morbidity and frequent hospitalization.
Dose-dense adjuvant chemotherapy in early breast cancer: 15–year results of the phase III Mammella InterGruppo (MIG)-1 study
Authors: E. Blondeaux, M. Cantore, A. Michelotti, B. Conte, M. Benasso, C. Bighin, M. Lambertini, F. Poggio, L. Del Mastro
Journal: Annals of Oncology (2019)
Abstract 4543: Nuclear receptor estrogen-related receptor alpha promotes hypoxic growth prostate cancer cells
Authors: Chang Zou, Shan Yu, David T. Yew, Franky L. Chan
Journal: Cancer Research (2011)

Abstract Estrogen-related receptors (ERRα,β,γ) which share significant homology with estrogen receptors, are orphan nuclear receptors and constitutively transactivated without estrogen-binding. Among the three subtypes, ERRα has been characterized to play a pivotal role in diverse aspects of energy homeostasis, including oxidative phosphorylation and mitochondrial biogenesis, via its transcriptional regulation of target genes. Expression studies in clinical tumor tissues show that ERRα expression is positively associated with a few hormone-dependent cancers, including breast, ovarian and endometrial cancers, and has been proposed to be useful as a prognostic marker for these cancers. We have previously reported that ERRα displays a ubiquitous expression pattern in various prostatic cell lines and an apparent elevated expression in high grade prostate cancer. However, its exact functional roles and prognostic value in prostate cancer still remains unclear. In this study, we analyzed the functional significance of ERRα in prostate cancer cell growth regulation by its stable expression in a hormone-sensitive prostate cancer cell line LNCaP. Our results showed that stable expression of ERRα in LNCaP cells could enhance their in vitro cell proliferation, adhesion to fibronectin, invasion and colony formation capacities of LNCaP cells under both normoxia and hypoxia condition (1% O2), while such in vitro growth phenotypes could be suppressed by an ERRα specific antagonist XCT790, suggesting that ERRα-induced growth phenotypes were ERRα specific. Moreover, under hypoxia condition, stable ERRα over-expression could stabilize HIF1α protein, up-regulate VEGF expression with an ERRα dose dependent pattern. Taken together, our results showed that ERRα over expression promotes hypoxic growth of prostate cancer cells. (This study is supported by a RGC General Research Fund CUHK461009) Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4543. doi:10.1158/1538-7445.AM2011-4543
Association of Household Income With Life Expectancy and Cause-Specific Mortality in Norway, 2005-2015
Authors: Jonas Minet Kinge, Jørgen Heibø Modalsli, Simon Øverland, Håkon Kristian Gjessing, Mette Christophersen Tollånes, Ann Kristin Knudsen, Vegard Skirbekk, Bjørn Heine Strand, Siri Eldevik Håberg, Stein Emil Vollset
Journal: JAMA (2019)

Examining causes of death and making comparisons across countries may increase understanding of the income-related differences in life expectancy.To describe income-related differences in life expectancy and causes of death in Norway and to compare those differences with US estimates.A registry-based study including all Norwegian residents aged at least 40 years from 2005 to 2015.Household income adjusted for household size.Life expectancy at 40 years of age and cause-specific mortality.In total, 3 041 828 persons contributed 25 805 277 person-years and 441 768 deaths during the study period (mean [SD] age, 59.3 years [13.6]; mean [SD] number of household members per person, 2.5 [1.3]). Life expectancy was highest for women with income in the top 1% (86.4 years [95% CI, 85.7-87.1]) which was 8.4 years (95% CI, 7.2-9.6) longer than women with income in the lowest 1%. Men with the lowest 1% income had the lowest life expectancy (70.6 years [95% CI, 69.6-71.6]), which was 13.8 years (95% CI, 12.3-15.2) less than men with the top 1% income. From 2005 to 2015, the differences in life expectancy by income increased, largely attributable to deaths from cardiovascular disease, cancers, chronic obstructive pulmonary disease, and dementia in older age groups and substance use deaths and suicides in younger age groups. Over the same period, life expectancy for women in the highest income quartile increased 3.2 years (95% CI, 2.7-3.7), while life expectancy for women in the lowest income quartile decreased 0.4 years (95% CI, -1.0 to 0.2). For men, life expectancy increased 3.1 years (95% CI, 2.5-3.7) in the highest income quartile and 0.9 years (95% CI, 0.2-1.6) in the lowest income quartile. Differences in life expectancy by income levels in Norway were similar to differences observed in the United States, except that life expectancy was higher in Norway in the lower to middle part of the income distribution in both men and women.In Norway, there were substantial and increasing gaps in life expectancy by income level from 2005 to 2015. The largest differences in life expectancy between Norway and United States were for individuals in the lower to middle part of the income distribution.