tbuckley/cabot-search huggingface dataset:
INDUCIBLE MYOCARDIAL ISCHEMIA AND HIGH-SENSITIVITY TROPONIN I ADDITIVELY PREDICT ADVERSE CARDIOVASCULAR EVENTS IN STABLE CORONARY ARTERY DISEASE
Authors: Jeong Hwan Kim, Muhammad Hammadah, Bruno Lima, Chang Liu, Yi-An Ko, Samaah Sullivan, Kasra Moazzami, Agim Beshiri, Gillian Murtagh, Ayman Alkhoder, Afif Martini, Laura Ward, Doug Bremner, Amit Shah, Brad D. Pearce, Ernest Garcia, Paolo Raggi, Viola Vaccarino, Arshed Quyyumi
Journal: Journal of the American College of Cardiology (2019)
Abstract 15228: Echocardiographic Abnormalities in Dialysis Patients Who Suffer Sudden Cardiac Arrest
Authors: Aapo L Aro, Audrey Uy-Evanado, Sandeep G Nair, Kyndaron Reinier, Carmen Teodorescu, Derek Phan, Gregory Nichols, Jonathan Jui, Sumeet S Chugh
Journal: Circulation (2016)

Introduction: Severely reduced kidney function and dialysis are associated with a significantly increased risk of sudden cardiac arrest (SCA), but predisposing factors are not fully understood. We ...
CONTRAST INDUCED NEPHROPATHY IN HEMODYNAMICALLY STABLE PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION: DOES LEFT VENTRICULAR END DIASTOLIC PRESSURE MATTER?
Authors: Justin Heizer, Muhammad Khan, Emilio Exaire, Zachary Gertz, Richard Cooke, Barbara Lawson, Luis Guzman
Journal: Journal of the American College of Cardiology (2019)
Pulmonary Effects of Immediate Versus Deferred Antriretroviral Treatment Initiation: Final Follow-Up Results from the Randomized Strategic Timing of Antiretroviral Treatment (START) Pulmonary Substudy
Authors: K. M. Kunisaki, D. E. Niewoehner, G. Collins, B. Aagaard, N. B. Atako, E. Bakowska, A. Clarke, G. M. Corbelli, E. Ekong, S. Emery, E. B. Finley, E. Florence, R. M. Infante, C. M. Kityo, J. S. Madero, D. E. Nixon, E. Tedaldi, J. Vestbo, R. Wood, J. E. Connett
Journal: American Journal of Respiratory and Critical Care Medicine (2018)
Abstract 333: TNF Receptor Modulation of Progenitor Cells and Exosomes for Myocardial Repair
Authors: Venkata N Garikipati, Maria Cimini, Chunlin Wang, Rajika Roy, Zhongjian Cheng, May M Truongcao, Cindy Benedict, Suresh K Verma, Walter J Koch, Raj Kishore, David A Goukassian
Journal: Circulation Research (2018)

Our published studies, using TNFR1 and TNFR2 knockout (KO) mice have demonstrated that negative effects of TNF during ischemic tissue repair including enhanced apoptosis and inflammatory cytokines expression and signaling, is largely mediated by TNFR1/p55. Our hypothesis is that inhibition of TNF-TNFR1 signaling inhibits multiple negative effects of TNF after myocardial ischemia by promoting TNF signaling through protective TNFR2 receptor and thereby augmenting EPC-mediated myocardial angiogenesis and repair and this enhanced protective effect of TNFR1 KO EPCs may involve alteration in the cargo and function of TNFR1-KO EPC derived exosomes. Protective effect of disrupted TNF-TNFR1/p55 signaling in BM-EPCs under stress conditions in WT, p55KO and p75KO EPCs were tested in tube formation assay under hypoxia conditions and H2O2 treatment. In the absence of TNFR1 (p55KO EPCs) - EC function of BM-EPCs is enhanced under normoxia/hypoxia conditions and survival of BM-EPCs is increased under oxidative stress. To test the effect of TNFR1 and TNFR2 loss in the BM-EPCs for recovery after AMI, WT mice were subjected to AMI and WT, p75KO and p55KO BM-EPCs were injected into the myocardium immediately after AMI. Compared to WT and p75KO, injection of p55KO EPCs into WT hosts led to - increased retention of p55KO EPCs in the WT mice hearts; decreased post-MI apoptosis in WT mice; increased vascular network; significantly improved cardiac function; substantially small infarct size; the last three indicating improved cardiac remodeling by day 21 post-AMI. Further, in vitro exosome studies showed that compared to WT and p75KOs, p55KO BM-EPCs-derived exosomes showed positive activities in vitro, including - enhanced angiogenic function in HUVECs and increased survival of H9C2 cells. These effects were mediated via upregulation of miRNA-191-5p as shown by increased levels of angiogenic miR-191-5p in the exosomal cargo of p55KO EPCs and near complete inhibition of HUVEC angiogenic function in vitro by miR-191-5p-antagomiR. Our findings suggest that decrease/loss of TNFR1 modulates both the content and function of EPC exosomes and enhance reparative and angiogenic capabilities of EPCs and EPC-mediated vascular and anatomical repair in the MI model.
QUANTITATIVE ASSESSMENT OF RIGHT VENTRICULAR SYSTOLIC FUNCTION BY TRICUSPID ANNULAR PLANE SYSTOLIC EXCURSION MEASURED FROM THE RIGHT VENTRICULAR INFLOW VIEW DURING TRANSTHORACIC ECHOCARDIOGRAPHY
Authors: Graham V. Byrum, Diego Malaver, Joseph Yeboah, Dalane Kitzman, Geoffrey Jao
Journal: Journal of the American College of Cardiology (2019)
OUTCOMES IN HOSPITALIZED OLDER AFRICAN AMERICAN PATIENTS WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFPEF)
Authors: Matt Nazari, Gauravpal S. Gill, Awais Malik, Lakshmi Tummala, Cherinne Arundel, Gurusher Panjrath, Steven Singh, Richard M. Allman, Charles Faselis, Gregg C. Fonarow, Ali Ahmed
Journal: Journal of the American College of Cardiology (2019)
CORONARY MICROVASCULAR DYSFUNCTION IS INDUCED BY HEMODYNAMIC INSTABILITY: QUANTITATION BY CONTROLLED FLOW INFUSION
Authors: Robert Schwartz, Jon Hoem, Nikola Cesarovic, Oliver Bludau, Mareike Gastl, Esther Gerteis, Blathnaid Feldman, Jonathan Schwartz, Martin Rothman
Journal: Journal of the American College of Cardiology (2019)
Abstract 502: Identifying Tetraspanins and Integrins Relevant to Cardiovascular Conditions Using Bioinformatics
Authors: Ge Sun
Journal: Circulation Research (2018)

Objectives: Our study aims at mining the bioinformatic databases to find potential cardiovascular (CV) regulators from tetraspanins and integrins. Methods: The Genotype-Tissue Expression (GTEx) was used to identify the tissue-specific mRNA level of each gene in CV system. The database of Genotypes and Phenotypes (dbGaP) was used to identify the association between genes and CV phenotypes through SNPs. Gene Expression Omnibus (GEO), was used for human gene correlation and functional prediction. GeneNetwork was used to find gene-phenotype or gene-gene correlation in mice. Results: The GTEx results are shown in the heatmaps (panel A). In dbGaP, we found ITGA8 has impact on cholesterol, along with ITGA9 on arterial pressure, ITGA2, ITGAE and ITGAM on platelet function tests, all from exon missense mutations. TSPAN5, TSPAN15, ITGA2 and ITGA6 are worth mentioning for their multiple intron SNP associations. GEO analysis showed that CD9, CD82, CD151, TSPAN18, UPK1B and most of the integrins are associated with genes related to CV phenotypes. In GeneNetwork, numerous associations were found in mice (table). Combining the data from both species: TSPAN5 and ITGA8 are associated with blood metabolic chemistry; TSPAN9 is associated cardiac ischemic conditions; TSPAN11 with fat/weight; CD82 and ITGA9 with blood pressure; ITGAM, ITGA2 and ITGB6 with platelet functions. The network graphs in the panel C show the correlated genes of these 9 final candidates in mouse aorta. Conclusion: Bioinformatic analyses revealed CVS-related candidates: TSPAN5, TSPAN9, TSPAN11, CD82, and ITGAM, A2, A8, A9, B6. These results require further confirmation by experimental methods.
RELATIONSHIP BETWEEN PATIENT-REPORTED OUTCOMES AND CARDIAC BIOMARKERS: THE PREDICTION, RISK, AND EVALUATION OF MAJOR ADVERSE CARDIAC EVENTS (PRE-MACE) STUDY BASELINE RESULTS
Authors: Chrisandra Shufelt, Susan Cheng, Garth Fuller, Sandy Joung, Mitra Mastali, Kelly Mouapi, Qin Fu, Mayra Lopez, Brennan Spiegel, Jennifer Van Eyk, C. Noel Bairey Merz
Journal: Journal of the American College of Cardiology (2019)
IMPACT OF OVERWEIGHT/OBESITY ON CLINICAL OUTCOMES OF PATIENT WITH VASOSPASTIC ANGINA: FROM THE VASOSPASTIC ANGINA IN KOREA REGISTRY
Authors: Min-Ho Lee, Seongsoon Kwon, Byung Won Park, Duk Won Bang, Min Su Hyon, Sang Hong Baek, Seung Hwan Han, Seung-Woon Rha, Sung-Ho Her, Dong Il Shin, Dong-Ju Choi, Hyeon-Cheol Gwon, Sung Eun Kim, Won-Woo Seo, Sang-Ho Jo
Journal: Journal of the American College of Cardiology (2019)
Abstract 445: Essential Role of the S100A1-C-terminus Domain in Maintaining Cardiac-inotrope S100A1 Protein Stability
Authors: Zegeye H Jebessa, Jemmy Zhao, Andrea Schneider, Martin Busch, Hugo A Katus, Patrick Most
Journal: Circulation Research (2018)

Introduction: S100A1 is a type of S100 protein with two EF-hand motif. It has a unique characteristic of interacting with multiple proteins of contractile machinery &amp; mitochondria. S100A1 protein able to govern proper systolic &amp; diastolic performance of cardiomyocyte interacting, respectively, with SERCA2A &amp; RYR2. S100A1 level decreases dramatically as a consequence of cellular cues such as oxidative-stress or activation of cellular proteasomes. Selective reconstitution of reduced S100A1 level by AAV9-gene transfer rescued failing heart. Because of the unique ability of S100A1 to interact with myriads of proteins with multiple function, we aimed to dissect the structure-function relationship of the domains of S100A1. Methods &amp; results: The C-terminus domain of S100A1 (S100A1ct) equally recapitulated the inotropic &amp; other benefits of the S100A1-FL in experimental model of heart failure &amp; identified as the bioactive lead domain of S100A1. To elucidate the function of the S100A1 without the C-terminus, here after, referred as S100A1ΔCT, we adenoviraly expressed S100A1ΔCT, &amp; as a control, either expressing GFP or S100A1-FL. We, inadvertently, discovered that S100A1ΔCT could not be detected at protein level. PCR analysis &amp; sequencing proved the presence S100A1ΔCT mRNA transcript. Bioinformatics revealed the presence of SUMO interaction motif (SIM) with in the C-terminus &amp; multiple ubiquitination residues on S100A1ΔCT, suggesting the SIM domain of the S100A1 is crucial for stability. Inhibition of cellular proteasome lead to the detection of the S100A1ΔCT protein in cells over expressing S100A1ΔCT. We overexpressed S100a1ΔCT, deletion mutants having part of the SIM motif (S100a1-SIM - ), the entire motif (S100a1-SIM + ) &amp; the S100a1-FL. Whereas the overexpression of S100A1-SIM + &amp; S100A1-FL were detected, S100A1ΔCT &amp; S100A1-SIM - could not be detected at protein level. Conclusion: The C-terminus of S100A1 is essential for stability of S100A1, besides, its potent inotropic function. Taken together, we deciphered the previously unrecognized posttranslational modification governed S100A1 regulation, thus providing new insight into the development of novel therapeutic strategies for heart failure via posttranslational manipulation of S100A1.
IMPACT OF DISTAL VESSEL QUALITY ON ACUTE PROCEDURAL OUTCOMES IN CTO PCI: INSIGHT FROM THE PROGRESS CTO REGISTRY
Authors: Peter Tajti, Dimitrios Karmpaliotis, Khaldoon Alaswad, Farouc Jaffer, Robert Yeh, Mitul Patel, Ehtisham Mahmud, James Choi, M. Nicholas Burke, Catalin Toma, Srinivasa Potluri, R. Michael Wyman, David Kandzari, Santiago Garcia, Oleg Krestyaninov, Dmitrii Khelimskii, Michalis Koutouzis, Jaikirshan Khatri, Wissam Jaber, Ajay Kirtane, Allison Hall, Iosif Xenogiannis, Bavana Rangan, Subhash Banerjee, Emmanouil Brilakis
Journal: Journal of the American College of Cardiology (2019)
Abstract 392: Chronic Dantrolene Treatment Attenuates Cardiac Dysfunction and Reduces Atrial Fibrillation Inducibility in a Rat Myocardial Infarction Heart Failure Model
Authors: Colleen Nofi, Kuo Zhang, Ying Li, Allan Migirov, Kaie Ojamaa, Martin Gerdes
Journal: Circulation Research (2018)

Background: Cardiac ryanodine receptor (RyR2) dysfunction and diastolic Ca 2+ leak have been linked to arrhythmogenesis not only in inherited arrhythmia syndromes but also in acquired forms of heart disease including heart failure (HF) and atrial fibrillation (AF). Thus, stabilizing RyR2 may confer therapeutic effects in these conditions. Objective: This study is to investigate the effects of stabilizing RyR2 with chronic dantrolene treatment on HF development and AF inducibility in a myocardial infarction (MI) induced HF model in rats. Methods: MI was induced in adult Sprague-Dawley rats by ligation of the left anterior descending coronary artery. Two weeks following MI surgery, rats with large MI ( &gt; 40%) were randomly assigned into MI+vehicle (n=13) and MI+dantrolene (10mg/kg/d, n=13) groups. Sham-surgery rats (n=7) served as controls. Results: Compared to vehicle-treated MI group, 4-week dantrolene treatment significantly improved cardiac function with increased left ventricle (LV) fractional shortening (19.48±3.61 vs 15.43±2.65, p&lt;0.01), decreased LV end-diastolic pressure (12.58±8.52 vs 21.91±7.25, p&lt;0.01), left atrial diameter (4.97±0.75 vs 6.09±1.53 p&lt;0.05) and left atrial fibrosis content. Dantrolene significantly decreased AF inducibility (69% (9 of 13) in MI-vehicle vs 23% (3 of 13) in MI-dantrolene group, p &lt;0.05). Dantrolene treatment was associated with reduced phosphorylation of RyR2, and favorably altered gene expressions involving ionic channels, sympathetic signaling, oxidative stress, and inflammatory markers. Conclusion: Chronic dantrolene treatment attenuated LV dysfunction and reduced AF inducibility, which were associated with decreased phosphorylation of RyR2 and restoration of many adverse changes in gene expression. Stabilizing RyR2 with dantrolene is a promising treatment in HF and AF.
COMPARISON OF NANOSTIM AND MICRA TRANSCATHETER LEADLESS PACEMAKER (LP) EXTRACTIONS: A MULTICENTER EXPERIENCE
Authors: Tawseef Dar, Bharath Yarlagadda, Muhammad Afzal, Sharan Sharma, Paul Friedman, Vivek Reddy, Rakesh Gopinathannair, Sandeep Gautam, Gregory Flaker, Zhenguo Liu, Greg Flaker, Andrea Natale, Dhanunjaya Lakkireddy
Journal: Journal of the American College of Cardiology (2019)
MYOCARDIAL MICRO-INJURY IS ASSOCIATED WITH IMPAIRED LV SYSTOLIC AND DIASTOLIC FUNCTION IN OLDER COMMUNITY-BASED INDIVIDUALS WITHOUT CARDIOVASCULAR DISEASE - ASSESSMENT BY SPECKLE TRACKING ECHOCARDIOGRAPHIC MEASUREMENT OF LV AND LA STRAIN: THE CARDIOVASCULAR HEALTH STUDY (CHS)
Authors: John S. Gottdiener, Stephen Seliger, Christopher DeFilippi, Robert Christenson, Jorge Kizer, Bruce Psaty, Sanjiv Shah
Journal: Journal of the American College of Cardiology (2019)
PLATELET MITOCHONDRIA ENHANCE INFLAMMATORY SETTING AND APOPTOSIS IN DIABETIC PATIENTS WITH NSTE ACUTE CORONARY SYNDROME
Authors: Maria Chiara Grimaldi, Iacopo Fabiani, Paolo Aretini, Giovanna Liuzzo, Larosa Giulio, Massimo Volpe, Filippo Crea, Luigi Biasucci
Journal: Journal of the American College of Cardiology (2019)
SUCCESSFUL ABLATION OF A MULTIFOCAL ATRIAL TACHYCARDIA BY PULMONARY VEIN ISOLATION
Authors: Nilubon Methachittiphan, Brandon Woodbury, Anne Kroman, Suresh Kumar Kulandhaisamy, Nazem Akoum, Arun Sridhar Mahankali
Journal: Journal of the American College of Cardiology (2019)
EFFECT OF PULMONARY ARTERIAL HYPERTENSION SPECIFIC THERAPY IN THE FOUR CLINICAL SUBGROUPS OF PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION ASSOCIATED WITH CONGENITAL HEART DISEASE
Authors: Massimiliano Palazzini, Alessandra Manes, Fabio Dardi, Enrico Gotti, Andrea Rinaldi, Andrea Cassani, Elisa Zuffa, Daniele Guarino, Filippo Pasca, Alessandro De Lorenzis, Ilenia Magnani, Mariangela Rotunno, Nazzareno Galiè
Journal: Journal of the American College of Cardiology (2019)
Toll-like receptor 7 deficiency promotes survival and reduces adverse left ventricular remodelling after myocardial infarction
Authors: Dominique P V de Kleijn, Suet Yen Chong, Xiaoyuan Wang, Siti Maryam J M Yatim, Anna-Marie Fairhurst, Flora Vernooij, Olga Zharkova, Mark Y Chan, Roger S Y Foo, Leo Timmers, Carolyn S P Lam, Jiong-Wei Wang
Journal: Cardiovascular Research (2019)

The Toll-like receptor 7 (TLR7) is an intracellular innate immune receptor activated by nucleic acids shed from dying cells leading to activation of the innate immune system. Since innate immune system activation is involved in the response to myocardial infarction (MI), this study aims to identify if TLR7 is involved in post-MI ischaemic injury and adverse remodelling after MI.TLR7 involvement in MI was investigated in human tissue from patients with ischaemic heart failure, as well as in a mouse model of permanent left anterior descending artery occlusion in C57BL/6J wild type and TLR7 deficient (TLR7-/-) mice. TLR7 expression was up-regulated in human and mouse ischaemic myocardium after MI. Compared to wild type mice, TLR7-/- mice had less acute cardiac rupture associated with blunted activation of matrix metalloproteinase 2, increased expression of tissue inhibitor of metalloproteinase 1, recruitment of more myofibroblasts, and the formation of a myocardial scar with higher collagen fibre density. Furthermore, inflammatory cell influx and inflammatory cytokine expression post-MI were reduced in the TLR7-/- heart. During a 28-day follow-up after MI, TLR7 deficiency resulted in less chronic adverse left ventricular remodelling and better cardiac function. Bone marrow (BM) transplantation experiments showed that TLR7 deficiency in BM-derived cells preserved cardiac function after MI.In acute MI, TLR7 mediates the response to acute cardiac injury and chronic remodelling probably via modulation of post-MI scar formation and BM-derived inflammatory infiltration of the myocardium.
Survival after peri-operative chemotherapy with folfox 4 and surgery for resectable colorectal cancer liver metastases. Final results of the eortc intergroup randomized phase III study 40983
Authors: B. Nordlinger, H. Sorbye, L. Collette, M. Praet, B. Glimelius, G. Poston, P. Schlag, P. Rougier, W. Bechstein, J. Primrose, E. Walpole, M. Finch-Jones, D. Jaeck, D. Mirza, R. Parks, T. Gruenberger
Journal: Annals of Oncology (2007)
DIFFERENCES IN OUTCOMES FOLLOWING BARE METAL OR DRUG ELUTING STENT PLACEMENT BEFORE TRANSCATHETER AORTIC VALVE REPLACEMENT IN THE ELDERLY
Authors: Tamunoinemi Bob-Manuel, Rikin Kadakia, Vinod Chainani, Tameem Rezan, David Knopf, Russell Riehl, David Gachoka, James Jenkins, Stephen Ramee, Jose Tafur Soto
Journal: Journal of the American College of Cardiology (2019)
COMPARISON OF ECHOCARDIOGRAPHIC VASCULAR, VALVULAR, AND MYOCARDIAL VARIABLES IN PATIENTS WITH SEVERE AORTIC STENOSIS AND PRESERVED EJECTION FRACTION GROUPED BY FLOW AND GRADIENT
Authors: Sagar Joshi, Robert Garvin, Fawad Virk, Lin Gao, Xiaoying Yu, Mohamed Morsy, Tareq Abu Sharifeh, Masood Ahmad, Rafic Berbarie
Journal: Journal of the American College of Cardiology (2019)
Abstract 103: Cytochrome b5 Reductase 3 Regulates Myoglobin Redox State and Controls Cardiac Function
Authors: Nolan T Carew, Helene M Altmann, Joseph C Galley, Scott Hahn, Megan P Miller, Sruti Shiva, Dennis McNamara, Adam C Straub
Journal: Circulation Research (2018)

Oxidative stress contributes to the adverse pathophysiology of cardiac remodeling in heart failure. During oxidative stress, hemoprotein heme-iron can be oxidized, often altering the function of these proteins. We previously reported that cytochrome b5 reductase 3 (Cyb5R3) regulates heme iron redox in the vascular wall. While conducting vasoreactivity studies with a small-molecule Cyb5R3 inhibitor, we unexpectedly observed inhibition resulted in dilated cardiomyopathy (DCM) with reduced ejection fraction. Based on this study, we generated the first cardiomyocyte Cyb5R3 knockout mouse. Heart specific Cyb5R3 knockout resulted in DCM with &gt;50% lethality in 15 days. H&amp;E staining, wheat germ agglutinin immunofluorescence staining, transmission electron microscopy and diffusion tensor MRI shows that loss of Cyb5R3 causes myocardial atrophy and fibrosis. Due to the known heme iron reducing function of Cyb5R3, electron paramagnetic resonance (EPR) was used to assess the abundance of reduced and oxidized myoglobin ex vivo. Cyb5R3 knockout hearts had approximately 30% more oxidation relative to controls. Hypoxyprobe staining, which senses tissue pO2 below 5mmHg, showed Cyb5R3 expression is required for maintaining intra-cardiomyocyte pO 2 , likely through myoglobin heme-iron reduction. Decreased pO 2 was supported by altered mitochondrial dynamics. Complex IV activity was significantly reduced, along with decreased mitochondrial size and total ATP. Heme degradation protein, heme oxygenase-1 (HO-1) was significantly upregulated, suggesting that Cyb5R3 knockout may result in increased free-heme toxicity leading to intracellular damage. To translate these findings to humans, we conducted a retrospective study using a high-frequency T117S variant in African Americans. T117S carriers had significantly accelerated mortality post-first acute cardiac event. A T117S mouse was generated and received trans-aortic constriction (TAC) for 2 weeks. Preliminary results suggest T117S TAC mice have accelerated cardiac remodeling and time to death after pressure overload relative to C57B6/J TAC controls. Together, these data support Cyb5R3 expression may have an important role as a heme-iron reductase in cardiomyocyte function.
COMPARISON OF BACKGROUND PHARMACOLOGIC THERAPY IN THE ANTHEM-HF PILOT STUDY TO CONTEMPORARY TRIALS OF NOVEL HEART FAILURE THERAPIES
Authors: Rajendra K. Premchand, Kamal Sharma, Sanjay Mittal, Rufino Monteiro, Imad Libbus, Jeffrey Ardell, Bruce Kenknight, Badri Amurthur, Lorenzo DiCarlo, Inderjit Anand
Journal: Journal of the American College of Cardiology (2019)
EFFECT OF RANOLAZINE ON ACTIVITY LEVEL IN PATIENTS WITH ANGINA AFTER FRACTIONAL FLOW RESERVE BASED DEFERRED INTERVENTION
Authors: Amit Malhotra, Yaser Cheema, Dharmesh Patel, Darrell Sneed, Gilbert Zoghbi, Justin May, Arie Szatkowski, Diana Barker, Brian Dragutsky, Huibo Shao
Journal: Journal of the American College of Cardiology (2019)
The Depletion of TGF-β Co-Receptor CD109 Induces Erythroid Differentiation of TF-1 Cells: A Model of Preferential Commitment of PIGA-Mutated Hematopoietic Stem Cells in Immune-Mediated Bone Marrow Failure
Authors: Tanabe Mikoto, Noriharu Nakagawa, Kohei Hosokawa, Luis Espinoza, Kana Maruyama, Takamasa Katagiri, Hirohito Yamazaki, Shinji Nakao
Journal: Blood (2018)
CRRL269 AS AN INNOVATIVE PARTICULATE GUANYLYL CYCLASE RECEPTOR (GC-A) PEPTIDE ACTIVATOR FOR ACUTE KIDNEY INJURY TREATMENT
Authors: Yang Chen, Gail Harty, Ye Zheng, Shinobu Sugihara, Seethalakshmi Iyer, Jeson Sangaralingham, Tomoko Ichiki, John C. Burnett
Journal: Journal of the American College of Cardiology (2019)
PREDICTION OF LATE GADORINIUM ENHANCEMENT IN PATIENTS WITH CARDIOMYOPATHY BY NATIVE T1 MAPPING AND GLOBAL STRAIN ON 3 TESLA-CARDIAC MAGNETIC RESONANCE
Authors: Yumiko Kanzaki, Takahide Ito, Koichi Sohmiya, Masaaki Hoshiga
Journal: Journal of the American College of Cardiology (2019)
Using Administrative Data to Identify Relapse and Hematopoietic Stem Cell Transplantation (HSCT) in Children with Acute Lymphoblastic Leukemia (ALL): Validation at Two Centers and Incidence Estimation in a National Cohort
Authors: Viviane C. Cahen, Yimei Li, Caitlin W Elgarten, Amanda M. DiNofia, Jennifer J. Wilkes, Lena E. Winestone, Yuan-Shung V. Huang, M. Monica Gramatges, Karen R. Rabin, Brian T. Fisher, Kelly D Getz, Richard Aplenc, Alix E. Seif
Journal: Blood (2018)
PREDICTORS FOR THE NEED FOR NEW PERMANENT PACEMAKER IMPLANTATION, AND HIGH PACING BURDEN ON FOLLOW-UP AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT WITH THE EDWARDS-SAPIEN 3 VALVE
Authors: Soroosh Kiani, Norihiko Kamioka, John Lisko, Andenet Mengistu, James Stewart, Patrick Gleason, Kendra Grubb, Adam B. Greenbaum, Chandan Devireddy, Robert Guyton, Bradley Leshnower, Vasilis Babaliaros, Michael Hoskins
Journal: Journal of the American College of Cardiology (2019)
LEFT MAIN- AND NON-LEFT MAIN-RELATED EVENTS AFTER REVASCULARIZATION: INSIGHTS FROM THE EXCEL TRIAL
Authors: Akiko Fujino, Akiko Maehara, Masaru Ishida, Ioanna Kosmidou, Gary Mintz, Patrick W. Serruys, Arie P. Kappetein, John Puskas, David Kandzari, Ori Ben-Yefuda, Ovidiu Dressler, Marie C. Morice, David Taggart, Bela Merkely, Ferenc Horkay, Joseph Sabik, Gregg Stone
Journal: Journal of the American College of Cardiology (2019)