tbuckley/cabot-search huggingface dataset:
Challenges and strategies for developing efficacious and long-lasting malaria vaccines
Authors: James G. Beeson, Liriye Kurtovic, Carlota Dobaño, D. Herbert Opi, Jo-Anne Chan, Gaoqian Feng, Michael F. Good, Linda Reiling, Michelle J. Boyle
Journal: Science Translational Medicine (2019)

New knowledge and strategies are emerging to enable the development of an efficacious and long-lasting vaccine against malaria.
FRI0683 Investigation of the relationship between plantar pressure distribution and lumbar multifidus muscle thickness
Authors: C. Karartı, S. Bilgin, Y. Dadalı, E. Dülger, B. Büyükturan, Ö. Büyükturan
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background:</h3> Lumbar multifidus is a muscle which is responsible for lumbopelvic stability primarily. Foot-ankle posture and function disorders affecting the lumbopelvic region muscles and biomechanics, cause increased stress in the lumbopelvic region and may cause low back pain in many studies (1,2,3). However, it is not known whether the lumbar multifidus muscle is affected by this condition (4,5). <h3>Objectives:</h3> Plantar pressure distribution can change due to foot-ankle postural disorders. Our aim is to examine whether the plantar pressure distribution affects the lumbar multifidus muscle thickness. <h3>Methods:</h3> 40 healthy young adults aged 18 to 25 years were included in the study. Static and dynamic pedobarographic assessments were performed to determine the plantar pressure distribution, on a 3x1 meter sensored walking platform with the DIASU Digital Analysis System®. Peak pressures (N/cm²) of 9 zones of the foot (medial of heel, lateral of foot, 5 metatarsal, thumb and 2.3.4 and 5. digits) were recorded. Ultrasonographic imaging was used to assess lumbar multifidus muscle thickness. <h3>Results:</h3> There was statistically significant correlation between lumbar multifidus muscle thickness and peak pressure medial of heel and 1. metatarsal bone in static pedobarographic analysis (p&lt;0.05). As the peak pressure on the medial part of foot increased, m. lumbar multifidus muscle thickness was reduced. There was statistically significant correlation between lumbar multifidus muscle thickness and pressure medial of heel and 2.3.4. and 5. digits in dynamic pedobarographic analysis (p&lt;0.05). As the peak pressure on the medial part of foot increased, m. lumbar multifidus muscle thickness was reduced. <h3>Conclusions:</h3> Our results show that plantar pressure distribution affected lumbar multifidus muscle thickness. Based on these results, the lumbopelvic region and foot posture should be considered together in therapeutic interventions. <h3>References</h3> 1. Bird AR, Payne CB. Foot function and low back pain. Foot1999;9(4):175–80. 2. Botte RR. An interpretation of the pronation syndrome and foot types of patients with low back pain. J Am Podiatry Assoc1981;71(5):243–53. 3. Barwick A, Smith J, Chuter V. The relationship between foot motion and lumbopelvic-hip function: a review of the literature. Foot (Edinb)2012;22(3):224–31. 4. Brantingham JW, Adams KJ, Cooley JR, Globe D, Globe G. A single-blind pilot study to determine risk and association between navicular drop, calcaneal eversion and low back pain. J Manipulative Physiol Ther2007;30(5):380–5. 5. Fourchet F, Kelly L, Horobeanu C, Loepelt H, Taiar R, Millet G. High-intensity running and plantar-flexor fatigability and plantar-pressure distribution in adolescent runners. J Athl Train2015;50(2):117–25. <h3>Disclosure of Interest:</h3> None declared
Spinal cord involvement in multiple sclerosis and neuromyelitis optica spectrum disorders
Authors: Olga Ciccarelli, Jeffrey A Cohen, Stephen C Reingold, Brian G Weinshenker, Maria Pia Amato, Brenda Banwell, Frederik Barkhof, Bruce Bebo, Burkhard Becher, François Bethoux, Alexander Brandt, Wallace Brownlee, Peter Calabresi, Jeremy Chatway, Claudia Chien, Tanuja Chitnis, Olga Ciccarelli, Jeffrey Cohen, Giancarlo Comi, Jorge Correale, Jerome De Sèze, Nicola De Stefano, Franz Fazekas, Eoin Flanagan, Mark Freedman, Kazuo Fujihara, Steven Galetta, Myla Goldman, Benjamin Greenberg, Hans-Peter Hartung, Bernhard Hemmer, Anke Henning, Izlem Izbudak, Ludwig Kappos, Hans Lassmann, Cornelia Laule, Michael Levy, Fred Lublin, Claudia Lucchinetti, Carsten Lukas, Ruth Ann Marrie, Aaron Miller, David Miller, Xavier Montalban, Ellen Mowry, Sebastien Ourselin, Friedemann Paul, Daniel Pelletier, Jean-Philippe Ranjeva, Daniel Reich, Stephen Reingold, Maria Assunta Rocca, Alex Rovira, Regina Schlaerger, Per Soelberg Sorensen, Maria Sormani, Olaf Stuve, Alan Thompson, Mar Tintoré, Anthony Traboulsee, Bruce Trapp, Maria Trojano, Bernard Uitdehaag, Sandra Vukusic, Emmanuelle Waubant, Brian Weinshenker, Claudia Gandini Wheeler-Kingshott, Junqian Xu
Journal: The Lancet Neurology (2019)
Abstract 18302: Echocardiography versus Autopsy in the San Francisco POstmortem Systematic InvesTigation of Sudden Cardiac Death (POST SCD) Study
Authors: Satvik Ramakrishna, Annie Bedigian, Joanne Probert, Eric Vittinghoff, Lisa Lim, Jeffrey E Olgin, Philip C Ursell, Ellen Moffatt, Zian H Tseng, Francesca Delling
Journal: Circulation (2017)

Introduction: Left ventricular hypertrophy (LVH) by transthoracic echocardiography (TTE) is associated with increased risk of sudden cardiac death (SCD). Prior studies have inferred causes of SCD f...
Nurses, shift work, and diabetes: should late chronotype be considered as a risk factor?
Authors: Roberto Manfredini, Rosaria Cappadona, Fabio Fabbian
Journal: BMJ (2019)

Shan and colleagues show that duration of rotating night shift work and unhealthy lifestyle are independently and jointly associated with a higher risk of type 2 diabetes in nurses.1 Among the possible determinants of an unhealthy lifestyle, however, they don’t mention disruption of circadian rhythms and chronotype (individual circadian preference).

Horne …
Hydroxyurea Exhibits Antioxidant Activity Via the Nrf2 Pathway- Antioxidant/Electrophile Response Element Regulated By p62/ SQSTM1
Authors: Sanzio Santana, Thassila Nogueira Pitanga, Jeanne Machado de Santana, Dalila Lucíola Zanette, Corynne Stephanie A. Adanho, Nívea Farias Luz, Valéria Matos Borges, Marilda Souza Goncalves
Journal: Blood (2018)
Sodium and water handling during hemodialysis: new pathophysiologic insights and management approaches for improving outcomes in end-stage kidney disease
Authors: Bernard Canaud, Jeroen Kooman, Nicholas M. Selby, Maarten Taal, Susan Francis, Pascal Kopperschmidt, Andreas Maierhofer, Peter Kotanko, Jens Titze
Journal: Kidney International (2019)

Space medicine and new technology such as magnetic resonance imaging of tissue sodium stores (23NaMRI) have changed our understanding of human sodium homeostasis and pathophysiology. It has become evident that body sodium comprises 3 main components. Two compartments have been traditionally recognized, namely one that is circulating and systemically active via its osmotic action, and one slowly exchangeable pool located in the bones. The third, recently described pool represents sodium stored in skin and muscle interstitium, and it is implicated in cell and biologic activities via local hypertonicity and sodium clearance mechanisms. This in-depth review provides a comprehensive view on the pathophysiology and existing knowledge gaps of systemic hemodynamic and tissue sodium accumulation in dialysis patients. Furthermore, we discuss how the combination of novel technologies to quantitate tissue salt accumulation (e.g., 23NaMRI) with devices to facilitate the precise attainment of a prescribed hemodialytic sodium mass balance (e.g., sodium and water balancing modules) will improve our therapeutic approach to sodium management in dialysis patients. While prospective studies are required, we think that these new diagnostic and sodium balancing tools will enhance our ability to pursue more personalized therapeutic interventions on sodium and water management, with the eventual goal of improving dialysis patient outcomes.
Immune Tolerance Induction for FIX Inhibitors Using Combined B and T Cell Immune Modulation Therapy in Severe Hemophilia B
Authors: Yasmina L. Abajas, Paul Edward Monahan, Brenda Nielsen, Pia Petrini, Susanna Ranta, Geoffrey A. Allen, Silvia Horneff, Annika Martensson, Johannes Oldenburg, Rolf Ljung
Journal: Blood (2018)
Reply to correspondence concerning: “Role of liver and spleen stiffness in predicting the recurrence of hepatocellular carcinoma after resection”
Authors: Giovanni Marasco, Antonio Colecchia, Agostino Colli, Federico Ravaioli, Giovanni Casazza, Maria Letizia Bacchi Reggiani, Alessandro Cucchetti, Matteo Cescon, Davide Festi
Journal: Journal of Hepatology (2019)
Abstract 13583: Iron Restriction Reduces Abdominal Aortic Aneurysm Formation in Angiotensin II-Infused Apolipoprotein E Deficient Mice
Authors: Hisashi Sawada, Yoshiro Naito, Hiroyuki Hao, Makiko Oboshi, Shinichi Hirotani, Toshihiro Iwasaku, Yoshitaka Okuhara, Daisuke Morisawa, Akiyo Eguchi, Seiichi Hirota, Mitsumasa Ohyanagi, Tohru Masuyama
Journal: Circulation (2013)

Background: Abdominal aortic aneurysm (AAA) is a common degenerative vascular disease. However, the exact cause of AAA is unknown. Iron is an essential element for maintaining physiological functio...
SP0091 Us for peripheral nerve entrapments + demo
Authors: D.A. Bong
Journal: Annals of the Rheumatic Diseases (2018)

<h3></h3> Symptoms related to entrapment of the peripheral nerves of the upper and lower extremity are common in rheumatologic practice and are often misinterpreted as articular or non neurologic periarticular pathology. Owing to the varible trajectory and mobility of the peripheral nerves, high resolution musculoskeletal ultrasound (US) has many advantages over other imaging modalities including superior resolution, ability to perform a dynamic real-time examination, precise sonopalpation and comparison with the contralateral structures. Its availability, relative ease of application in experienced hands and tolerance argue for its use as the initial “intervention” when compared to electrophysiologic testing. Large, medium and many smaller nerves can be imaged directly (along with the musculoskeletal terrain through which they pass ) depending on the quality of the instrumentation, skill and anatomic knowledge of the sonographer. Even pathologic involvement of smallest “nonvisualized” small nerves may be deduced by secondary changes of the innervated musculature, the so-called “echo-myogram”. Obviously a thorough knowledge of the peripheral neuroanatomy and musculuskeletal relationships along the nerve trajectory is the key to an enhanced and reliable evaluation. This presentation will focus on the principles of neuro-sonoanatomy of the major peripheral nerve of the extremities and the fundamentals of the peripheral nerve US examination will be demonstrated. <h3>Disclosure of Interest</h3> None declared
Abstract 13975: The Association Between Oxidative Stress and Premature Atherosclerosis in Early Childhood Patients With Kawasaki Disease
Authors: Takamichi Ishikawa, Keigo Seki
Journal: Circulation (2017)

Introduction: Oxidative stress has recently been shown to play an important role in the development of atherosclerosis in patients with Kawasaki disease (KD); however, no study has investigated this association in early childhood patients with KD. In this study, we evaluated prospectively the association between the levels of oxidative stress and the endothelial function in early childhood patients with KD. Methods: We performed a prospective study comparing the derivatives of reactive oxygen metabolites (ROM), flow-mediated dilatation (FMD), and biological characteristics in a population of 50 children: 10 patients with KD and coronary artery lesions (CAL) (group 1), 15 KD patients without CAL (group 2), and 25 healthy age- and sex-matched children (group 3). Results: The median age of all KD children at study enrollment was 6.8 (IQR 4.4-8.2) years. ROM levels were significantly higher in group 1 (p<0.001) and group 2 (p=0.004) than in group 3. The %FMD of group 1 (p<0.001) and group 2 (p=0.026) was sign...
Adults with cystic fibrosis and pulmonologists: new training needed to recruit future specialists
Authors: Francesco Blasi, J. Stuart Elborn, Paolo Palange
Journal: European Respiratory Journal (2019)

<b>Pulmonologists should take the lead in the management of adults with cystic fibrosis. Considerable efforts in research and education are required to ensure all patients to receive a high standard of care.</b>http://ow.ly/cTCb30n22bF
SP0162 Look at the cascade : clinical observations
Authors: K. Briot
Journal: Annals of the Rheumatic Diseases (2018)

<h3></h3> Vertebral fracture (VF) is the most common osteoporotic fracture, and a strong risk factor of subsequent vertebral fracture. Prospective studies have shown that a recent VF increases an imminent risk of a subsequent one, and attention has been paid recently to a possible cascade phenomenon i.e. the occurrence of multiples VFs in less than one year after discontinuation of denosumab (rebound vertebral fractures) in postmenopausal osteoporosis and in patients receiving aromatase inhibitors. Vertebral fracture cascade has been reported in secondary causes of osteoporosis (after the initiation of systemic glucocorticoids, in endocrine disease, benign hemopathies as mastocytosis and in pregnancy-and lactation-associated osteoporosis). We reported the clinical obsevations of patients with multiples vertebral fractures occurring over one year and we discussed the causes, the potential risk factors and the appropriate management. <h3>Disclosure of Interest</h3> None declared
Low-intensity focused ultrasound for the treatment of brain diseases: safety and feasibility
Authors: Giada Toccaceli, Giuseppe Barbagallo, Simone Peschillo
Journal: Theranostics (2019)

The use of focused ultrasound (FUS) as a tool for blood-brain barrier (BBB) permeabilization is opening new ways for the treatment of several pathologies, in particular brain tumors and neurodegenerative diseases. However, even if there are promising results in these fields, the efficacy and safety of this technique is unknown in long-term follow-up. The study of Blackmore et al. [Theranostics 2018; 8(22):6233-6247. doi:10.7150/thno.27941] evaluated the long-term effects of FUS on brain parenchyma in aged mice with Alzheimer's disease. This is the first study which applied a multimodal analysis to demonstrate the safety of FUS in aged brain in view of a potential introduction of this technique in common clinical practice in the future.
British Association of Dermatologists guidelines for the safe and effective prescribing of oral ciclosporin in dermatology 2018
Authors: J. Berth‐Jones, L.S. Exton, E. Ladoyanni, M.F. Mohd Mustapa, V.M. Tebbs, P.D. Yesudian, N.J. Levell, P.M. McHenry, T.A. Leslie, S. Wakelin, R.Y.P. Hunasehally, M. Cork, G.A. Johnston, N. Chiang, F.S. Worsnop, A. Salim, D. Buckley, G. Petrof, N. Callachand, T. Flavell, A.A. Salad
Journal: British Journal of Dermatology (2019)
SAT0715 Risk factors of immune-related adverse events in patients treated with anti-pd-1 antibody pembrolizumab
Authors: Y. Eun, I.Y. Kim, H. Kim, J.K. Ahn, E.-J. Park, J. Hwang, H. Jeong, J.Y. Chai, H.-S. Cha, E.-M. Koh, J. Lee
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Immune checkpoint inhibitors targeting cytotoxic T-lymphocyte-associated protein 4 and programmed cell death protein 1 (PD-1) have been established as a novel standard treatment for various types of malignancies. However, these new class of drugs have led to increased immune-related adverse events (IrAEs) including rheumatic manifestations. <h3>Objectives</h3> To determine the risk factors of IrAEs in patients treated with anti-PD 1 antibody pembrolizumab. <h3>Methods</h3> A retrospective medical record review was performed to identify all patients who received at least one dose of pembrolizumab at Samsung Medical Centre, Seoul, Korea between June 2015 and December 2017. Three hundred and ninety two patients were identified. Multivariate logistic regression model was used to identify risk factors of IrAEs. <h3>Results</h3> The mean age was 59.7±13.0 years (range, 18–95) and the median number of doses of pembrolizumab was 2 (IQR, 1.25–5). The primary malignancies included in the study were lung cancer (n=212, 54.1%), melanoma (n=74, 18.9%), lymphoma (n=53, 13.5%) and others (n=53, 13.5%). Sixty-seven (17.1%) patients experienced clinically significant IrAEs; most commonly dermatologic disorders (n=39, 9.9%), pneumonitis (n=11, 2.8%), musculoskeletal disorders (n=10, 2.6%), followed by endocrine disorders (n=7, 1.8%). Fourteen patients (3.6%) experienced serious IrAEs (≥Grade 3). Most common serious IrAEs were pneumonitis (n=9, 2.3%). There were 4 deaths associated with IrAEs, all of which were due to pneumonitis. Multivariate logistic regression analysis showed that obesity was the risk factors of IrAEs in pembrolizumab-treated patients. Patients with a body mass index (BMI) of 25 or higher had a 3.65-fold higher risk of IrAEs compared with patients with a BMI between 18.5 and 22.9 (95% CI, 1.58 to 8.42). <h3>Conclusions</h3> To our knowledge, this is the first study to explore the risk factor for IrAE in patients undergoing modern cancer immunotherapy. Our study demonstrate that BMI is associated with an increased risk of IrAEs in patients treated with pembrolizumab. Further studies to investigate the potential mechanisms by which obesity raises IRAEs are needed. <h3>Disclosure of Interest</h3> None declared
An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles
Authors: Angelica Ortiz, Jun Gui, Farima Zahedi, Pengfei Yu, Christina Cho, Sabyasachi Bhattacharya, Christopher J. Carbone, Qiujing Yu, Kanstantsin V. Katlinski, Yuliya V. Katlinskaya, Simran Handa, Victor Haas, Susan W. Volk, Angela K. Brice, Kim Wals, Nicholas J. Matheson, Robin Antrobus, Sonja Ludwig, Theresa L. Whiteside, Cindy Sander, Ahmad A. Tarhini, John M. Kirkwood, Paul J. Lehner, Wei Guo, Hallgeir Rui, Andy J. Minn, Constantinos Koumenis, J. Alan Diehl, Serge Y. Fuchs
Journal: Cancer Cell (2019)
Gain Fat—Lose Metastasis: Converting Invasive Breast Cancer Cells into Adipocytes Inhibits Cancer Metastasis
Authors: Dana Ishay-Ronen, Maren Diepenbruck, Ravi Kiran Reddy Kalathur, Nami Sugiyama, Stefanie Tiede, Robert Ivanek, Glenn Bantug, Marco Francesco Morini, Junrong Wang, Christoph Hess, Gerhard Christofori
Journal: Cancer Cell (2019)
OP0175 Interferon signature might serve as early biomarker for development of lupus and correlates strongly with myxovirus-resistance protein a
Authors: W. Lambers, H. Westra, B. Doornbos-van der Meer, M. Jonkman, H. Bootsma, K. de Leeuw
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Incomplete systemic lupus erythematosus (iSLE) marks a group of patients with typical features of SLE, who do not meet classification criteria. Up to 55% progress to SLE, but there are no predictive markers available. Interferon (IFN) type-I is an important early mediator in SLE. The majority of SLE patients show upregulation of interferon-inducible genes. Levels of IFN-related soluble markers, which are more easily applicable, are also increased in SLE. <h3>Objectives</h3> To measure IFN signature and IFN-related soluble markers in iSLE patients to determine if these can serve as predictors of SLE. <h3>Methods</h3> Thirty iSLE patients (ANA titer ≥1:80, disease duration &lt;5 years,≥1 ACR clinical feature), 39 SLE patients with quiescent disease (fulfilling ACR or SLICC criteria, SLEDAI ≤4) and 11 healthy controls (HC) were included. Clinical and serological data were retrieved from medical charts. RNA was isolated from whole blood using PAXgene tubes, reversely transcribed to cDNA and quantitatively analysed by Real time PCR. IFN score was calculated based on cumulative expression of 12 IFN-related transcripts (IP-10, IFI44L, IFIT3, LY6E, MX1, SERPING1, IFITM1, IRF7, STAT1, C1QA, IFI16 and IRF9). A positive IFN-score was defined as &gt;2 SD of the mean of the control group. Levels of IFN-related mediators, including IFN-γ induced protein 10 (IP-10) and Myxovirus-resistance protein A (MxA) were measured using ELISA. Statistical significance between groups was tested with Mann-Whitney U tests. Correlations of continuous data were calculated using Spearman's r test. <h3>Results</h3> Baseline characteristics are shown in table 1. An increased IFN score was present in 55% of iSLE patients (p=0.05) and 46% of SLE patients (p=0.07) (figure 1a).In iSLE, IFN score correlated positively with ESR (<i>r</i>=0.52, p=0.004), SSA titer (<i>r</i>=0.64, p=0.02) and cumulative number of ENA (<i>r</i>=0.57, p=0.001), and negatively with leukocyte count (<i>r</i>=-0.38, p=0.04), Hb (<i>r</i>=-0.39, p=0.04), and C4 (<i>r</i>=-0.47, p=0.01). SLEDAI, clinical symptoms, nor use of hydroxychloroquine were correlated with IFN score. Levels of MxA correlated strongly with IFN score in both iSLE (<i>r</i>=0.78, p&lt;0.0001) (figure 1b) and SLE (<i>r</i>=0.6, p&lt;0.0001). IP-10 levels correlated with IFN score in iSLE (<i>r</i>=0.45, p=0.02), but not in SLE. <h3>Conclusions</h3> IFN-signature is present in 55% of patients with iSLE and correlates with ESR, autoantibody number, leukopenia, anaemia and hypocomplementemia. Interestingly, MxA levels correlated strongly with IFN-gene upregulation and thus might be a suitable and easily applicable surrogate marker for IFN type-I activity. iSLE patients with IFN upregulation might be those at most risk for disease progression; longitudinal data however should be awaited. <h3>Disclosure of Interest</h3> None declared
Predicting Response to BET Inhibitor in Combination with Palbociclib / Sorafenib Using a Computational Model and Its Validation: A Beat AML Project Study
Authors: Jeffrey W. Tyner, Brian J. Druker, Stephen E Kurtz, Cristina E. Tognon, Leylah M. Drusbosky, Robinson Vidva, Yugandhara Narvekar, Ashish Kumar Agrawal, Saji Gera, Samiksha Avinash Prasad, Vijayashree P Shyamasundar, Gaurav Singh Tunwer, Taher Abbasi, Shireen Vali, Christopher R. Cogle
Journal: Blood (2018)
Final Safety and Efficacy Results from the CPX-351 Early Access Program (EAP) for Older Patients with High-Risk/Secondary Acute Myeloid Leukemia (sAML)
Authors: Gail J. Roboz, Melissa L. Larson, S. Eric Rubenstein, Scott R Solomon, Gary J. Schiller, Qi An, Emaryn Mancino, Michael Chiarella, Arthur C. Louie, Tara L Lin
Journal: Blood (2018)