tbuckley/cabot-search huggingface dataset:
The Evolutionary History of Ephs and Ephrins: Toward Multicellular Organisms
Authors: Aida Arcas, David G Wilkinson, M Ángela Nieto
Journal: Molecular Biology and Evolution (2019)

Eph receptor (Eph) and ephrin signaling regulate fundamental developmental processes through both forward and reverse signaling triggered upon cell-cell contact. In vertebrates, they are both classified into classes A and B, and some representatives have been identified in many metazoan groups, where their expression and functions have been well studied. We have extended previous phylogenetic analyses and examined the presence of Eph and ephrins in the tree of life to determine their origin and evolution. We have found that 1) premetazoan choanoflagellates may already have rudimental Eph/ephrin signaling as they have an Eph-/ephrin-like pair and homologs of downstream-signaling genes; 2) both forward- and reverse-downstream signaling might already occur in Porifera since sponges have most genes involved in these types of signaling; 3) the nonvertebrate metazoan Eph is a type-B receptor that can bind ephrins regardless of their membrane-anchoring structure, glycosylphosphatidylinositol, or transmembrane; 4) Eph/ephrin cross-class binding is specific to Gnathostomata; and 5) kinase-dead Eph receptors can be traced back to Gnathostomata. We conclude that Eph/ephrin signaling is of older origin than previously believed. We also examined the presence of protein domains associated with functional characteristics and the appearance and conservation of downstream-signaling pathways to understand the original and derived functions of Ephs and ephrins. We find that the evolutionary history of these gene families points to an ancestral function in cell-cell interactions that could contribute to the emergence of multicellularity and, in particular, to the required segregation of cell populations.
Regulation of Rho GTPases by the Hematopoietic-Specific Guanine Nucleotide Exchange Factor Vav1 Is Critical for Hematopoietic Stem Cell Retention in the Endosteal Niche and Engraftment.
Authors: Abel Sanchez-Aguilera, Yun-Jung Lee, Cristina Lo Celso, Kristina Brumme, Charles P Lin, David T Scadden, David A. Williams
Journal: Blood (2009)
IgA and IgG Hypogammaglobulinemia Are Associated with Mutations in the APRIL/BLYS Receptor TACI in Waldenstrom’s Macroglobulinemia (WM).
Authors: Zachary Hunter, Xavier Leleu, Evdoxia Hatjiharissi, Daniel Santos, Lian Xu, Alan Ho, Vinod Bakthavachalam, Anne-Sophie Moreau, Kelly O’Connor, Jacob Soumerai, Christopher Patterson, Irene Ghobrial, Susanna Hamilton, Sigitas Verselis, Edward Fox, Steven Treon
Journal: Blood (2006)
CCL5 of glioma-associated microglia/macrophages regulates glioma migration and invasion via calcium-dependent matrix metalloproteinase 2
Authors: Caren Yu-Ju Wu, Chia-Hua Chen, Chun-Yen Lin, Li-Ying Feng, Yung-Chang Lin, Kuo-Chen Wei, Chiung-Yin Huang, Jia-You Fang, Pin-Yuan Chen
Journal: Neuro-Oncology (2019)

Abstract Background Glioma-associated microglia/macrophages (GAMs) comprise macrophages of peripheral origin and brain-intrinsic microglia, which support tumor progression. Chemokine C-C ligand 5 (CCL5) is an inflammatory mediator produced by immune cells and is involved in tumor growth and migration in several cancers, including glioma. However, the mechanisms detailing how CCL5 facilitates glioma invasion remain largely unresolved. Methods Glioma migration and invasion were determined by wound healing, transwell assay, and 3D µ-slide chemotaxis assay. The expression levels of CCL5, CD68, matrix metalloproteinase 2 (MMP2), phosphorylated Ca2+/calmodulin-dependent protein kinase II (p-CaMKII), p-Akt, and phosphorylated proline-rich tyrosine kinase 2 were determined by cytokine array, quantitative PCR, western blot, or immunohistochemistry. Zymography and intracellular calcium assays were used to analyze MMP2 activity and intracellular calcium levels, respectively. Results CCL5 modulated the migratory and invasive activities of human glioma cells in association with MMP2 expression. In response to CCL5, glioma cells underwent a synchronized increase in intracellular calcium levels and p-CaMKII and p-Akt expression levels. CCL5-directed glioma invasion and increases in MMP2 were suppressed after inhibition of p-CaMKII. Glioma cells tended to migrate toward GAM-conditioned media activated by granulocyte-macrophage colony-stimulating factor (GM-CSF) in which CCL5 was abundant. This homing effect was associated with MMP2 upregulation, and could be ameliorated either by controlling intracellular and extracellular calcium levels or by CCL5 antagonism. Clinical results also revealed the associations between CCL5 and GAM activation. Conclusion Our results suggest that modulation of glioma CaMKII may restrict the effect of CCL5 on glioma invasion and could be a potential therapeutic target for alleviating glioma growth.
Lower Relapse Incidence after Non-Cryopreserved Autologous Bone Marrow Transplantation Compared to Peripheral Blood Stem Cell Transplantation for High-Risk Hodgkin’s Lymphoma.
Authors: Jerzy Holowiecki, Sebastian Giebel, Malgorzata Krawczyk-Kulis, Jerzy Wojnar, Lucja Kachel, Maria Sadus-Wojciechowska, Beata Stella-Holowiecka, Sebastian Grosicki, Tomasz Czerw
Journal: Blood (2004)
Assessment of Surgeon Variation in Adherence to Evidence-Based Recommendations for Treatment of Trigger Finger
Authors: Jessica I. Billig, Kelly A. Speth, Jacob S. Nasser, Lu Wang, Kevin C. Chung
Journal: JAMA Network Open (2019)

<h3>Importance</h3> Stenosing tenosynovitis (trigger finger) affects approximately 2% of the population. Given the prevalence of trigger finger and rising health care costs, adherence to the cost-effective and evidence-based treatment algorithm will permit better outcomes and allocation of resources. <h3>Objectives</h3> To examine treatment patterns for trigger finger and to determine surgeon-level and patient-level factors that influence adherence to evidence-based treatment. <h3>Design, Setting, and Participants</h3> This retrospective population-based cohort study examined deidentified claims for treatment of trigger finger from a national insurance provider using the Clinformatics Data Mart database. Patients were included if they were 18 years or older and treated from January 1, 2002, through December 31, 2016 (excluding a washout period from July 1, 2008, until June 30, 2010), with a new diagnosis of single-digit trigger finger. Data were analyzed from December 21, 2018, through April 28, 2019. <h3>Exposures</h3> Cost-effective and evidence-based research published in July 2009 for the treatment of trigger finger. <h3>Main Outcomes and Measures</h3> After excluding the 1-year washout period on either side of July 1, 2009, adherence to the recommended treatment algorithm of 2 corticosteroid injections before surgical release of trigger finger was compared with practice before publication of research supporting this cost-effective and evidence-based approach. <h3>Results</h3> In this analysis of 83 667 patients with trigger finger, 52 698 (63.0%) were women, and 20 045 (24.0%) had type 1 or 2 diabetes. Mean (SD) age was 61 (13) years. From 2002 to 2016, an overall increasing trend in adherence to the cost-effective and evidence-based approach to treatment was noted, with no significant increase in adherence in the postpublication era (67.5% vs 73.3%;<i>P</i> = .27). Substantial variation in adherence was observed at the surgeon level (intraclass correlation, 33%). Plastic surgeons had no change in adherence over time compared with orthopedic surgeons (odds ratio [OR], 1.00; 95% CI, 0.98-1.02;<i>P</i> = .90), whereas general surgeons had increased adherence (OR, 1.04; 95% CI, 1.02-1.06;<i>P</i> &lt; .001). Higher-volume surgeons were also more adherent to these evidence-based recommendations (OR, 1.59; 95% CI, 1.53-1.65;<i>P</i> &lt; .001). <h3>Conclusions and Relevance</h3> This study found substantial surgeon-level variation in adherence to evidence-based treatment of trigger finger. Surgeon specialty and volume were associated with differences in adherence. Efforts to understand surgeon barriers to implementation, regardless of physician specialty, appear to be necessary, and better implementation strategies may permit increased uptake of evidence-based treatment of trigger finger.
Multikinase Inhibitor Sorafenib Induces Apoptosis, CD138-Downregulation, Actin Depolymerization and Inhibition of M210B4-Triggered Chemotaxis in Multiple Myeloma Cell Lines and Synergyzes with Proteasome Inhibitor Bortezomib
Authors: Josefina Udi, Dagmar Wider, Julie Catusse, Dominik Schnerch, Marie Follo, Gabriele Ihorst, Ralph Waesch, Monika Engelhardt
Journal: Blood (2011)
Risk Factors and a Prognostic Score for Progression Free Survival after Treatment with Autologous Stem Cell Transplantation (ASCT) in Patients with Relapsed or Refractory Hodgkin Lymphoma (rrHL)
Authors: Paul J Bröckelmann, Horst Müller, Olivier Casasnovas, Martin Hutchings, Bastian von Tresckow, Peter Borchmann, Craig Moskowitz, Andreas Engert
Journal: Blood (2015)
Efficacy and safety of early administration of pegfilgrastim for esophageal cancer treated with DCF: A phase 2 study
Authors: Tomoyo Yasuda, Takeshi Ishikawa, Osamu Dohi, Tetsuya Okayama, Naohisa Yoshida, Kazuhiro Kamada, Kazuhiko Uchiyama, Osamu Handa, Tomohisa Takagi, Atsushi Shiozaki, Hitoshi Fujiwara, Hideyuki Konishi, Yuji Naito, Yoshito Itoh
Journal: Annals of Oncology (2019)
Clinical Features and Treatment Outcomes of Non-Hodgkin's Lymphoma with Breast Involvement; Multi-Institutional Analysis of 98 Patients in Korea.
Authors: Jae-Yong Kwak, Ho-Young Yhim, Hye Jin Kang, Seok Jin Kim, Won Seog Kim, Yee Soo Chae, Jin Seok Kim, Chul Won Choi, Sung Yong Oh, Hyeon Seok Eom, Jeong-A Kim, Jae Hoon Lee, Jong Ho Won, Hyeok Shim, Je-Jung Lee, Hwa Jung Sung, Hyo Jung Kim, Cheolwon Suh
Journal: Blood (2009)
Intensification of Chemotherapy Does Not Improve Prognosis of Standard Risk Patients Undergoing Therapy for Acute Myelogenous Leukemia: Results of the Pediatric Clinical Trial AML-BFM 98.
Authors: Ursula Creutzig, Dirk Reinhardt, Joerg Ritter, Guenter Henze, Johannes Hermann, Thomas Klingebiel, Thomas Lehrnbecher, Charlotte M. Niemeyer, Alfred Reiter, Helmut Gadner, Jan Stary, Martin Zimmermann
Journal: Blood (2004)
Response to Proteosome Inhibitors and Immunomodulatory Drugs before and after Allogeneic Transplantation in Patients with Multiple Myeloma: A Long Term Follow up Study
Authors: Lucia López Corral, Teresa Caballero Velázquez, Oriana López Godino, Laura Rosiñol, Francesc Fernandez-Avilés, Isabel Krsnik, D Morillo, Inmaculada Heras, Mireia Morgades, Jose J. Rifon, Antonia Sampol, P Iniesta, Verónica González, Montserrat Rovira, M Cabero, Cristina Castilla-Llorente, Josep-Maria Ribera, Marta Torres Juan, Jose Maria Moraleda, Carmen Martinez, A Vázquez, Gonzalo Gutierrez, Dolores Caballero, Jesus San Miguel, Maria-Victoria Mateos, Jose Antonio Pérez-Simón
Journal: Blood (2016)
High Incidence of Cytomegalovirus Reactivation and Diseases Following Reduced-Intensity Cord Blood Transplantation for Adult Patients.
Authors: Hisashi Yamamoto, Naoyuki Uchida, Tomoko Matsumura, Shinsuke Takagi, Daisuke Kato, Yoshiko Matsuhashi, Sachiko Seo, Naofumi Matsuno, Kazuhiro Masuoka, Atsushi Wake, Shigesaburo Miyakoshi, Akiko Yoneyama, Shuichi Taniguchi
Journal: Blood (2006)
Pruritic annular concentric plaques
Authors: Yue-Tong Qian, Dong-Lai Ma
Journal: BMJ (2019)

A previously healthy 32 year old man presented with a three month history of multiple well defined annular concentric plaques with slightly raised scaly borders on his scalp, forehead, right chest, back, left forearm, right groin, and thighs, with mild pruritis (fig 1). He had no associated fever, malaise, headache, or arthralgia. He reported having unprotected sexual intercourse with several female partners over the last year. No lesions were observed on the mucosal surfaces, palms, or soles. He …
A New Insight into Pediatric Leukemia: Che-1 Involvement in Oncogenic c-Myc Signaling
Authors: Valentina Folgiero, Cristina Sorino, Valentina Bertaina, Francesca De Nicola, Frauke Goeman, Paolo Romania, Matteo Pallocca, Doriana Fruci, Alice Bertaina, Luciana Vinti, Maurizio Fanciulli, Franco Locatelli
Journal: Blood (2016)
Cytotoxic Activity of Anti-CD20-hIFN-α on Rituximab-Resistant B-NHL Clones and Synergy with Chemotherapy,
Authors: Gabriel G Vega, Mario I Vega, Sara Huerta-Yepez, Ali Jazirehi, Hector Mayani, Otoniel Martinez-Maza, Sherie Morrison, Benjamin Bonavida
Journal: Blood (2011)
Exploring the Function of Sestrin/Gator As Novel Regulators of Hematopoiesis
Authors: Nina Kurrle, Frank Schnütgen, Juliana Heidler, Ina Poser, Frank Wempe, Diego Yepes, Ilka Wittig, Thomas Oellerich, Michael A Rieger, Harald von Melchner, Hubert Serve
Journal: Blood (2016)
Role of Mir-34 Upregulation in Disruption of c-Myc, c-Myb and NOTCH Signaling in Diamond-Blackfan Anemia
Authors: Mark Wilkes, Elena Bibikova, Minyoung Youn, Alex Gia Lee, Ascia Eskin, Stanley Nelson, Bertil Glader, Anupama Narla, Kathleen M. Sakamoto
Journal: Blood (2016)
Evaluation of the Risk of Hepatitis B Reactivation Among Patients with Chronic Myeloid Leukemia Treated with Tyrosine Kinase Inhibitors
Authors: Ohad Benjamini, Maya Zlotnick, Elena Ribakovsky, Meirav Kedmi, Adrian Duek, Drorit Merkel, Merav Leiba, Ivetta Danylesko, Noga Shem-Tov, Ronit Yerushalmi, Avichai Shimoni, Abraham Avigdor, Arnon Nagler, Yulia Volchek
Journal: Blood (2016)
The Role of Stromal Cells in Multiple Myeloma: Actors or Spectators?.
Authors: A. Corso, E. Ferretti, A. Gallì, A. M. Tenore, C. Pascutto, P. Zappasodi, S. Mangiacavalli, M. Varettoni, C. Rusconi, M. Lazzarino
Journal: Blood (2005)
Resistance to Danusertib (formerly PHA-739358) in BCR-ABL-Positive Cells Is Mediated by Upregulation of the Drug Transporter Abcg2 and Can Be Suppressed in Vitro by Combination Treatment with Imatinib.
Authors: Tim H Brummendorf, Artur Gontarewicz, Gunhild Keller, Jürgen Moll, Melanie Braig, Imke Rohe, Edgar Jost, Oliver Galm, Carsten Bokemeyer, Tessa Holyoake, Stefan Balabanov
Journal: Blood (2009)
Prognostic Factors of Elderly Diffuse Large B-Cell Lymphoma Treated with R-CHOP: Performance Status and Age Over Eighty, but Neither Lactate Dehydrogenase Level, Stage, Nor Relative Dose Intensity Delivered, Associated with Clinical Outcome
Authors: Kazunari Aoki, June Takeda, Yuki Hunayama, Nobuhiko Yamauchi, Aiko Kato, Yuichiro Ono, Hiroshi Arima, Yoko Takiuchi, Seiji Nagano, Sumie Tabata, Akiko Matsushita, Takayuki Ishikawa
Journal: Blood (2011)
Expectations and challenges for TeamOncology workshops
Authors: Chihiro Kondoh, Yoko Ichinari, Hajime Morita, Hisashi Suyama, Yumi Yoshii, Mio Ezura, Yoko Fujisawa, Hirotoshi Iihara, Mitsuki Kariya, Natsumi Matsumoto, Sanae Nakajima, Yoichi Osato, Fumihiro Terasaki, Mutsumi Yamagami, Manabu Futamura, Shigehira Saji, Naoto T. Ueno
Journal: Annals of Oncology (2019)
The Macrophage-Specific CD163 Is an Endocytic Receptor for Von Willebrand Factor (VWF) Cleaving Protease ADAMTS13
Authors: Fabian Verbij, Nicoletta Sorvillo, Paul Kaijen, Johana Hrdinova, Rob Fijnheer, Anja ten Brinke, Alexander B. Meijer, Floris P. van Alphen, Timo K. van der Berg, Jonas H. Graversen, Soren K. Moestrup, Jan Voorberg
Journal: Blood (2016)
A Newly Identified Translocation t(X;14)(p11;q32) In MALT Lymphoma Involving IGHS and GPR34 Reveals A Novel Role for GPR34 In Cell Growth and Tumor Development
Authors: Stephen M. Ansell, Takashi Akasaka, Michelle Manske, Tammy Price-troska, Steven Ziesmer, Esteban Braggio, Rafael Fonseca, Mamta Gupta, Mark E Law, Thomas E. Witzig, Martin JS Dyer, Ahmet Dogan, Anne J. Novak
Journal: Blood (2010)
Usefulness of NT-Probnp Levels and Fresco Cardiovascular Risk Scale for Prediction of Myocardiotoxicity Induced By Anthracyclines in Patients with Diffuse Large B-Cell Lymphoma
Authors: Mariana Paola Ferraro, Eva Gimeno, Miquel Gomez, Francesc Garcia-Pallarols, Silvia Perez, Blanca Sanchez-Gonzalez, Laia Martinez, Elena Torres, Eugenia Abella, Roberto Elosua, Josep Comín, Antonio Salar
Journal: Blood (2016)
Telomere Length Shortening in the CML Leukemic Stem Cell Compartment Correlates with the Respective Clone Size: Evidence for Early Vs. Late Chronic Phase
Authors: Anne-Sophie Bouillon, Monica S. Ferreira, Shady Adnan Awad, Johan Richter, Henrik Hjorth-Hansen, Thoas Fioretos, Sebastian Hummel, Mirle Schemionek, Satu Mustjoki, Fabian Beier, Tim H. Brümmendorf
Journal: Blood (2016)
A Novel Approach to Treatment of Paroxysmal Nocturnal Hemoglobinuria (PNH): Both Hemolysis and C3 Deposition Are Blocked by a Monoclonal Antibody (mAb) Specific for the Alternative Pathway of Complement (APC) C3/C5 Convertase.
Authors: Ronald P Taylor, Margaret A Lindorfer, Andrew W Pawluczkowycz, Charles J Parker
Journal: Blood (2009)
Flap Structure-Specific Endonuclease 1 (FEN1) May be a Key Mediator of Genome Instability in Myeloma: A Cellular Vulnerability with Potential Therapeutic Significance
Authors: Masood A Shammas, Leutz Buon, Subodh Kumar, Mehmet K. Samur, David Alagpulinsa, Purushothama Nanjappa, Nikhil C Munshi
Journal: Blood (2016)
Discovery and Validation of Cell-Surface Protein Mesothelin (MSLN) As a Novel Therapeutic Target in AML: Results from the COG/NCI Target AML Initiative
Authors: Katherine Tarlock, Allison J. Kaeding, Todd A. Alonzo, Michael R. Loken, Rhonda E. Ries, Laura Pardo, Robert Gerbing, Jason E Farrar, Jaime M. Guidry Auvil, Daniela S. Gerhard, Malcolm A. Smith, Tanja M. Davidsen, Pattee Gesuwan, Leandro C. Hermida, Marco A. Marra, Andrew J. Mungall, Karen Mungall, Yussanne Ma, Stuart Zong, William Long, Alan S. Gamis, E. Anders Kolb, Soheil Meshinchi
Journal: Blood (2016)
Second Allogeneic Bone Marrow Transplantation for Patients with Either Graft Failure or Relapsed Leukemia.
Authors: Stella Santarone, Erminia Di Bartolomeo, Pasqua Bavaro, Paolo Di Carlo, Paola Olioso, Gabriele Papalinetti, Antonella Sau, Paolo Di Bartolomeo
Journal: Blood (2005)
The Initial Level of MLL-PTD Affects the Prognosis of Patients with Acute Myeloid Leukemia
Authors: Jun Kong, Hao Jiang, Yazhen Qin, Xiaosu Zhao, Hong-Hu Zhu, Jinsong Jia, Qian Jiang, Jing Wang, Ting Zhao, Xiao-Jun Huang
Journal: Blood (2016)
Stabilization of the Mean Platelet Component (MPC), a Parameter Related to Platelet Granularity Provided by New Generation of Blood Analyzers.
Authors: Gines Escolar, Jose M. Jou, Maribel Diaz-Ricart, Marc Pino, Ful Navalon, Rosa Brugues, Anna Merino, James G. White
Journal: Blood (2006)
Notch Signaling By Either Notch1 or Notch2 Mediates Expansion of AGM-Derived Long-Term HSC Populations in Vitro
Authors: Brandon K Hadland, Barbara Varnum-Finney, Randall T Moon, Michael Gustave Poulos, Jason M. Butler, Shahin Rafii, Irwin D. Bernstein
Journal: Blood (2014)
Utility of Second and Subsequent Peripheral Blood Stem Cell (PBSC) Mobilization in Myeloma Patients
Authors: Samar Kulkarni, Adrian JC Bloor, Mike Dennis, Dianne Sweeney, Rita Angelica, Sarah Grantham, Siobhan Donaghey, Angela Leather, Lyndsey Ashton, James Cavet
Journal: Blood (2011)
Brain Natriuretic Peptide (BNP) Level as Marker of Cardiac Function in Imatinib - Treated Chronic Myeloid Leukemia Patients: No Evidence of Cardiotoxicity of Imatinib Therapy.
Authors: Mario Tiribelli, Antonio Colatutto, Luciana Marin, Eleonora Toffoletti, Giuseppe Barbina, Ugo Qualizza, Elio Tonutti, Anna Candoni, Marta Medeot, Daniela Damiani, Giorgio Morocutti, Sala Pierguido, Renato Fanin
Journal: Blood (2007)
TIMP–1 Plays a Functional Role in CD34. + Hematopoietic Stem and Progenitor Cells.
Authors: C. Matthias Wilk, Akos G. Czibere, Ron-Patrick Cadeddu, Sebastian Buest, Frank A. Schildberg, Marcel A. Lauterbach, Volker Westphal, Stefan W. Hell, Rainer Haas, Ingmar Bruns
Journal: Blood (2009)
Both Naïve and Memory T-Cell Subsets Participate in Alloresponses to HLA-Mismatched Targets – Implications for Adoptive Transfer of Viral Antigen-Specific T Cells.
Authors: J. Joseph Melenhorst, Phillip Scheinberg, Ann Williams, Keyvan Keyvanfar, Melody Smith, J. Philip McCoy, Nancy F. Hensel, A. John Barrett
Journal: Blood (2009)
Resveratrol, a Natural Antioxidant From Grapes and Red Wines, Prevents EBV-Associated Lymphoproliferation and Transformation through Inducing Apoptosis
Authors: Luis J. Espinoza, Akiyoshi Takami, Katsuya Nakata, Shunichi Kato, Yoshihito Kasahara, Shinji Nakao
Journal: Blood (2010)
Structural Chromosomal Changes Are Common Manifestation of FLT3 ITD Relapse and Presence of Chromosomal Progression Is Independent of Normal Karyotype at Diagnosis
Authors: Melanie Rebechi, Wesley Hand, B. Douglas Smith, Ivana Gojo, Margaret M. Showel, Gabrielle T Prince, Douglas Gladstone, Shannon R. McCurdy, Gabriel Ghiaur, Lukasz P Gondek, Amy E. DeZern, Mark J. Levis, Keith W. Pratz
Journal: Blood (2016)
Immunosuppression Modulates Immune Responses to AAV Capsid in Human Subjects Undergoing Intramuscular Gene Transfer for Lipoprotein Lipase Deficiency
Authors: Daniel J Hui, Federico Mingozzi, Annemarie Kleefstra, Janneke M Meulenberg, Shyrie Edmonson, Denise Morin, Daniel Gaudet, Sander van Deventer, Katherine A. High
Journal: Blood (2008)
The Hematopoietic Reconstitution Defect of Mice Lacking CXCR4 Is Related to an Altered Retention of Hematopoietic Cells in the Bone Marrow.
Authors: Adlen Foudi, Yanyan Zhang, Jean-Francois Geay, Magali Berthebaud, Dorothee Buet, Peggy Jarrier, Takashi Nagasawa, William Vainchenker, Fawzia Louache
Journal: Blood (2004)
Targeting Cell-Bound MUC1 on Myelomonocytic and Monocytic Leukemias and Leukemic Stem Cells: Therapeutic Implications
Authors: Thierry Guillaume, Virginie Dehame, Patrice Chevallier, Pierre Peterlin, Marc Grégoire, Philippe Moreau, Daniel B Rubinstein, Eddy Pichinuk, Daniel H Wreschner
Journal: Blood (2015)
Altered Cytotoxicity Profile of <scp>CD</scp>8+ T Cells in Ankylosing Spondylitis
Authors: Eric Gracey, Yuchen Yao, Zoya Qaiyum, Melissa Lim, Michael Tang, Robert D. Inman
Journal: Arthritis & Rheumatology (2019)

Ankylosing spondylitis (AS) is an inflammatory arthritis in which men have a higher risk of developing progressive axial disease than women. Transcriptomic studies have shown reduced expression of cytotoxic cell genes in the blood of AS patients. HLA-B27 contributes the greatest risk for AS, suggesting a role for CD8+ T cells. This study was undertaken to profile AS patient cytotoxic cells with the hypothesis that an alteration in CD8+ T cells might explain the aberrant cytotoxic profile observed in patients.Whole blood was examined for GZM and PRF1 gene expression by quantitative polymerase chain reaction. Serum and synovial fluid (SF) were examined for granzyme and perforin 1 expression by bead array, and blood and SF mononuclear cells were examined for granzyme and perforin 1 expression by fluorescence-activated cell sorting (FACS).GZM and PRF1 gene expression were both reduced in AS patients compared to healthy controls, especially in men. Perforin 1, but not granzyme, protein levels were reduced in AS patient serum. Granzymes were elevated in AS SF, but not in rheumatoid arthritis or osteoarthritis SF. FACS revealed a reduction in granzyme-positive and perforin 1-positive lymphocytes, but not an intrinsic defect in CD8+ T cell granzyme or perforin 1 production. CD8+ T cell frequency was reduced in the blood and increased in the SF of AS patients.Our findings indicate that AS patients have an altered cytotoxic T cell profile. These data suggest that CD8+ T cells with a cytotoxic phenotype are recruited to the joints, where they exhibit an activated phenotype. Thus, a central role for CD8+ T cells in AS may have been overlooked and deserves further study.
Quality of Life in Myelodysplastic Syndromes and Physicians' Perception.
Authors: Esther Natalie Oliva, Valeria Santini, Poloni Antonella, Vincenzo Liso, Daniela Cilloni, Adelmo Terenzi, Patrizia Guglielmo, Riccardo Ghio, Agostino Cortelezzi, Giampietro Semenzato, Cristina Clissa, Flavia Salvi, Oreste Villani, Maria Antonietta Aloe Spiriti
Journal: Blood (2009)
Mutation in Wilms' Tumor 1 Induces DNA Hypermethylation of PRC2 Targets, Blocks Myelomonocytic Differentiation, and Defines a Novel Subtype of AML Responsive to EZH2 Inhibition
Authors: Daniel Thomas, Subarna Sinha, Linda Yu, Namyoung Jung, Bo Dai, Andrew J Gentles, Andrew P. Feinberg, David Dill, Ravindra Majeti
Journal: Blood (2014)