tbuckley/cabot-search huggingface dataset:
Validation of the Dutch Quality of Life in Hand Eczema Questionnaire ( <scp>QOLHEQ</scp> )
Authors: J.A.F. Oosterhaven, R.F. Ofenloch, M.L.A. Schuttelaar
Journal: British Journal of Dermatology (2019)

Measurement instruments should be validated for use in the population for which they are intended. The Quality of Life in Hand Eczema Questionnaire (QOLHEQ) has been developed to measure impairment of health‐related quality of life in patients with hand eczema. To assess validity, reproducibility, responsiveness and interpretability of the Dutch version of the QOLHEQ. This was a prospective validation study in adult patients with hand eczema. At three time points (T0, baseline; T1, after 1–3 days; T2, after 4–12 weeks), data from the QOLHEQ and multiple reference instruments were collected. Scale structure was assessed using item response theory analysis and structural equation modelling (SEM). Single‐score validity and responsiveness were tested with hypotheses on correlations with reference instruments. Concerning reproducibility, intraclass correlation coefficients (ICCagreement) and standard error of agreement (SEMagreement) were checked. Regarding interpretability, bands for severity of quality‐of‐life impairment were proposed. Also, smallest detectable change (SDC) and minimally important change (MIC) were determined. At T0, 300 individuals participated in the study (54% were male, mean age 45 years). Rescoring of the scale structure fitted the Rasch model and the SEM. The ICCagreement was 0·91 (95% confidence interval 0·85–0·94) and the SEMagreement was 5·2 points. Of the a priori formulated hypotheses, 80% (single‐score validity) and 64% (change scores for responsiveness) were confirmed. The SDC was 14·4 points and the MIC was 11·5 points. The Dutch version of the QOLHEQ has a good structural validity and reproducibility and has a high single‐score validity and moderate responsiveness. An improvement of ≥ 15 points should be regarded as a real, important change within the Dutch population. What's already known about this topic? The Quality of Life in Hand Eczema Questionnaire (QOLHEQ) measures impairment of health‐related quality of life (HRQoL) in patients with hand eczema. The QOLHEQ was validated in Germany and Japan, but the validity and interpretability of the Dutch version are unknown. What does this study add? This study shows that the Dutch QOLHEQ is a valid instrument to measure HRQoL impairment in Dutch patients with hand eczema, demonstrating good reliability and moderate responsiveness. Methods of item response theory are applied to assess and refine the scoring structure. Severity gradings to interpret single and change scores, specifically in Dutch patients, are proposed. What are the clinical implications of this work? The Dutch QOLHEQ can now be used to measure HRQoL impairment in Dutch patients with hand eczema. Linked Comment:Shen and Chen. Br J Dermatol 2020; 183:8–9.
Predictors of Hyperviscosity Syndrome (HVS) in Waldenström Macroglobulinemia (WM)
Authors: Jithma Prasad Abeykoon, Saurabh Zanwar, Shaji K Kumar, Morie A. Gertz, Grace Choong, Jeffrey L. Winters, S. Vincent Rajkumar, Ronald S Go, Thomas M Habermann, Martha Q Lacy, Thomas E Witzig, David Dingli, Angela Dispenzieri, Patrick B Johnston, Nelson Leung, Ivana N Micallef, Francis K Buadi, David J Inwards, Suzanne R. Hayman, Carrie A Thompson, Yi Lin, Wilson I Gonsalves, Taxiarchis Kourelis, Rahma Warsame, Robert A Kyle, Stephen M Ansell, Prashant Kapoor
Journal: Blood (2017)
TCT-329 Full Hemodynamic Characterization of Intracoronary Physiology: Merging Advanced Grayscale Intravascular Ultrasound With Fractional Flow Reserve
Authors: Cristiano Bezerra, Fábio Pinton, Breno Falcao, José Mariani, Alexandre Hideo-Kajita, Carlos Bulant, Pablo Blanco, Pedro A. Lemos
Journal: Journal of the American College of Cardiology (2019)
Sex Differences in Transfemoral Transcatheter Aortic Valve Replacement
Authors: Wieneke Vlastra, Jaya Chandrasekhar, Bruno García Del Blanco, Didier Tchétché, Fabio S de Brito, Marco Barbanti, Ran Kornowski, Azeem Latib, Augusto D'Onofrio, Flavio Ribichini, Jan Baan, Jan G P Tijssen, Raul Moreno, Nicolas Dumonteil, Flavio Tarasoutchi, Samantha Sartori, Paola D'Errigo, Giuseppe Tarantini, Mattia Lunardi, Katia Orvin, Matteo Pagnesi, Alberto Berenguer, Thomas Modine, George Dangas, Roxana Mehran, Jan J Piek, Ronak Delewi
Journal: Journal of the American College of Cardiology (2019)
In Non-Selected Patients Treated for Influenza, Oseltamivir, a Glycosialidase Inhibitor, Demonstrates Improvement in Platelet Counts Compared to Time of Dosing, but Not over Baseline Levels
Authors: Sabina I. Cashin, Melissa M. Lee-Sundlov, Karin M. Hoffmeister, Laura C. Michaelis
Journal: Blood (2017)
TCT-621 Diagnostic Performance of Resting Full-Cycle Ratio as Newly Developed Non-Hyperemic Indices for Physiological Lesion Assessment When Directly Compared With Fractional Flow Reserve as a Reference Standard
Authors: Hirofumi Ohashi, Hiroaki Takashima, Katsuhisa Waseda, Hirohiko Ando, Shinichiro Sakurai, Akihiro Suzuki, Kazuhiro Naito, Atomu Tajima
Journal: Journal of the American College of Cardiology (2019)
TCT-176 Implantation of Thin-Strut Sirolimus-Eluting Bioresorbable Vascular Scaffold in Patients With De Novo Coronary Artery Lesions: 2-Year Clinical and 6-Month Imaging Outcomes of the MeRes-1 Extend Trial
Authors: Alexandre Abizaid, Sasko Kedev, Rosli Bin Mohd Ali, Teguh Santoso, Angel Cequier, R.J.M. van Geuns, Bernard Chevalier, Farrel Hellig, Ricardo Costa, Yoshinobu Onuma, J. Ribamar Costa, Patrick Serruys, Sripal Bangalore
Journal: Journal of the American College of Cardiology (2019)
Hepatitis B vaccine birthdose practices in a country where hepatitis B is endemic - Laos, December 2011-February 2012.
Authors: Anonh Xeuatvongsa, Chansay Pathammavong, Kongxay Phounphenhack, Rita Reyburn, Keith Feldon, Melanie J. Thompson, Karen A. Hennessey, Minal K. Patel, Eyasu H. Teshale, Francisco Averhoff
Journal: MMWR Morbidity and Mortality Weekly Report (2013)
TCT-415 Platelet Reactivity Inhibition Following Ticagrelor Loading Dose in Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndrome
Authors: Vassili Panagides, Corinne Frere, Thomas Cuisset, Caroline Gouarne, Franck Thuny, Franck Paganelli, Marie-Christine Alessi, Julien Mancini, Laurent Bonello
Journal: Journal of the American College of Cardiology (2019)
TCT-262 Use of Sirolimus-Coated Balloon in Small Vessel De Novo Lesions: Midterm Follow-Up From a Single-Center Registry
Authors: Sandeep Basavarajaiah, Ishaq Mohammed, Sampath Athukorala, Handi Salim, Richard Watkin, Gurbir Bhatia, Jerome Ment, Kaeng Lee, Michael Pitt, George Pulikal, Bethan Freestone
Journal: Journal of the American College of Cardiology (2019)
Need for Consensus Guidelines in Pediatric Umbilical Hernia Repair
Authors: Shawn J. Rangel, Jonathan L. Hills-Dunlap
Journal: JAMA Pediatrics (2019)

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Alemtuzumab/Low Dose TBI Conditioning Facilitates Stable Long-Term Donor Hematopoietic Cell Engraftment from Sibling Donors in Children with Sickle Cell Disease
Authors: Gregory M Guilcher, Dania Monagel, Michael Leaker, Tony H Truong, Alberto Nettel-Aguirre, Aisha Bruce, Catherine Corriveau-Bourque, Sunil Desai, Victor A. Lewis
Journal: Blood (2017)
TCT-302 Safety and Clinical Performance of Biodegradable Polymer-Coated Ultrathin Strut Sirolimus-Eluting Stents: 2-Year Outcomes From “Real-World” Patient Population From the T-Flex Registry
Authors: Ramesh Babu Pothineni, Vikrant Vijan, Anil Potdar, M.K. Inamdar, Abhijit Pathak, Sai Sudhakar Mantravadi, Prakash Ajmera
Journal: Journal of the American College of Cardiology (2019)
TCT-482 Temporal Evaluation of a Biological Response and Functionality of a Novel, Balloon Expandable Transcatheter Aortic Valve System (MyVal) in a Model of Aortic Banding
Authors: Piotr Buszman, Krzysztof Milewski, Carlos Fernandez Ceballos, Magdalena Michalak, Armando Tellez, Serge Rousselle, Mateusz Kachel, Bogdan Gorycki, Pawel Buszman
Journal: Journal of the American College of Cardiology (2019)
Miro1 Marks Parkinson’s Disease Subset and Miro1 Reducer Rescues Neuron Loss in Parkinson’s Models
Authors: Chung-Han Hsieh, Li Li, Roeland Vanhauwaert, Kong T. Nguyen, Mary D. Davis, Guojun Bu, Zbigniew K. Wszolek, Xinnan Wang
Journal: Cell Metabolism (2019)
TCT-618 A Feasibility Study of the DyeVert™ Plus Contrast Reduction System to Reduce Contrast Media in Optical Coherence Tomography–Guided Percutaneous Coronary Interventions
Authors: Vladislav Zimin, Michael Jones, Tyler Richmond, Jared Durieux, Gabriel Tensol Rodrigues Pereira, Luis Dallan, Armando Vergara-Martel, Patricia Ely Pizzato, Hiram Bezerra
Journal: Journal of the American College of Cardiology (2019)
A Prospective Randomized Trial Comparing Hydrus and iStent Microinvasive Glaucoma Surgery Implants for Standalone Treatment of Open-Angle Glaucoma
Authors: Iqbal Ike K. Ahmed, Antonio Fea, Leon Au, Robert E. Ang, Paul Harasymowycz, Henry D. Jampel, Thomas W. Samuelson, David F. Chang, Douglas J. Rhee
Journal: Ophthalmology (2019)
Transforming growth factor beta 1 (TGF beta 1) participates in the regulation of liver specific functions in proliferating hepatocytes
Authors: Helene Lilja, Yukio Kamohara, Toomas Neuman, Achilles A Demetriou, Jacek Rozga
Journal: Hepatology (1998)

Transforming growth factor beta 1 (TGF beta 1) participates in the regulation of liver specific functions in proliferating hepatocytes
A Transcriptionally Definable Subgroup of Triple-Negative Breast and Ovarian Cancer Samples Shows Sensitivity to HSP90 Inhibition
Authors: Kevin Shee, Jason D. Wells, Matthew Ung, Riley A. Hampsch, Nicole A. Traphagen, Wei Yang, Stephanie C. Liu, Megan A. Zeldenrust, Liewei Wang, Krishna R. Kalari, Jia Yu, Judy C. Boughey, Eugene Demidenko, Arminja N. Kettenbach, Chao Cheng, Matthew P. Goetz, Todd W. Miller
Journal: Clinical Cancer Research (2019)

Abstract Purpose: We hypothesized that integrated analysis of cancer types from different lineages would reveal novel molecularly defined subgroups with unique therapeutic vulnerabilities. On the basis of the molecular similarities between subgroups of breast and ovarian cancers, we analyzed these cancers as a single cohort to test our hypothesis. Experimental Design: Identification of transcriptional subgroups of cancers and drug sensitivity analyses were performed using mined data. Cell line sensitivity to Hsp90 inhibitors (Hsp90i) was tested in vitro. The ability of a transcriptional signature to predict Hsp90i sensitivity was validated using cell lines, and cell line- and patient-derived xenograft (PDX) models. Mechanisms of Hsp90i sensitivity were uncovered using immunoblot and RNAi. Results: Transcriptomic analyses of breast and ovarian cancer cell lines uncovered two mixed subgroups comprised primarily of triple-negative breast and multiple ovarian cancer subtypes. Drug sensitivity analyses revealed that cells of one mixed subgroup are significantly more sensitive to Hsp90i compared with cells from all other cancer lineages evaluated. A gene expression classifier was generated that predicted Hsp90i sensitivity in vitro, and in cell line- and PDXs. Cells from the Hsp90i-sensitive subgroup underwent apoptosis mediated by Hsp90i-induced upregulation of the proapoptotic proteins Bim and PUMA. Conclusions: Our findings identify Hsp90i as a potential therapeutic strategy for a transcriptionally defined subgroup of ovarian and breast cancers. This study demonstrates that gene expression profiles may be useful to identify therapeutic vulnerabilities in tumor types with limited targetable genetic alterations, and to identify molecularly definable cancer subgroups that transcend lineage.
TCT-544 Influence of Ischemic and Bleeding Risk Factors on Diabetic Patients Undergoing Percutaneous Coronary Intervention: From the Xience Pooled Registry
Authors: Ridhima Goel, Davide Cao, Anastasios Roumeliotis, Rishi Chandiramani, Moritz Blum, Samantha Sartori, Lijuan Jenny Wang, Kai Koo, Giulio Stefanini, Marco Valgimigli, Roxana Mehran
Journal: Journal of the American College of Cardiology (2019)
<i>Lrrk2</i> alleles modulate inflammation during microbial infection of mice in a sex-dependent manner
Authors: Bojan Shutinoski, Mansoureh Hakimi, Irene E. Harmsen, Michaela Lunn, Juliana Rocha, Nathalie Lengacher, Yi Yuan Zhou, Jasmine Khan, Angela Nguyen, Quinton Hake-Volling, Daniel El-Kodsi, Juan Li, Azadeh Alikashani, Claudine Beauchamp, Jay Majithia, Kevin Coombs, Derya Shimshek, Paul C. Marcogliese, David S. Park, John D. Rioux, Dana J. Philpott, John M. Woulfe, Shawn Hayley, Subash Sad, Julianna J. Tomlinson, Earl G. Brown, Michael G. Schlossmacher
Journal: Science Translational Medicine (2019)

The Lrrk2 gene modulates the course of infections in mice in a sex-dependent manner.
Visit-to-Visit Fasting Glucose Variability in Young Adulthood and Hippocampal Integrity and Volume at Midlife
Authors: Zhenyu Xiong, Jiaying Li, Xiangbin Zhong, Shaozhao Zhang, Xiuting Sun, Huimin Zhou, Yunzhi Chen, Xiaodong Zhuang, Xinxue Liao
Journal: Diabetes Care (2019)

OBJECTIVE To determine whether visit-to-visit fasting glucose (VVFG) variability in young adulthood is associated with midlife hippocampal integrity and volume. RESEARCH DESIGN AND METHODS Multivariable-adjusted linear regression models were used to estimate the association between VVFG variability and brain MRI variables in 543 CARDIA study participants. VVFG variability was defined by the SD of FG (SDFG), the coefficient of variation of the mean FG (CVFG), and the average real variability (ARVFG) over 25 years of follow-up. Hippocampal integrity fractional anisotropy (FA) and tissue volume standardized to intracranial volume were measured by 3T MRI at year 25. RESULTS After multivariable adjustment, higher FG variability (1-SD increase) was associated with lower hippocampal FA (SDFG −0.015 [95% CI −0.026, −0.004]; CVFG −0.009 [95% CI −0.018, −0.001]; ARVFG −0.011 [95% CI −0.019, −0.002]) and lower hippocampal volume (SDFG −0.012 [95% CI −0.023, −0.001]). CONCLUSIONS Higher VVFG variability in young adulthood is associated with lower midlife hippocampal integrity and volume, suggesting its value in predicting risk for hippocampal structural damage.
TCT-137 Dose-Dependent Effects of Angiotensin-Converting-Enzyme Inhibitors and Angiotensin II Receptor Blockers on Clinical and Echocardiographic Outcomes After Transcatheter Aortic Valve Replacement
Authors: Brent Klinkhammer, Elizabeth Lyden, J. Dawn Abbott, Herbert Aronow, Thomas Porter, Andrew Goldsweig
Journal: Journal of the American College of Cardiology (2019)
Racial Differences and Factors Associated with Pregnancy in ESKD Patients on Dialysis in the United States
Authors: Silvi Shah, Annette L. Christianson, Karthikeyan Meganathan, Anthony C. Leonard, Daniel P. Schauer, Charuhas V. Thakar
Journal: Journal of the American Society of Nephrology (2019)

Significance Statement Pregnancy is not common in women on dialysis due to impaired fertility. Literature is scarce about pregnancy in women on dialysis in the United States. In this retrospective study, the authors examined the pregnancy rates and associated factors in 47,555 US women on dialysis from 2005 to 2013. They identified 2352 pregnancies, for a rate of 17.8 per thousand person years, a higher rate than seen in previous studies. Pregnancy rates were highest in Native American women followed by Hispanics, blacks, Asians, and whites. Younger age, hemodialysis as the dialysis modality, and ESKD caused by GN, vasculitis, neoplasm, and hypertension were associated with the higher likelihood of pregnancy. Patients with diabetes as the cause of ESKD had the lowest pregnancy rates. This study improves our understanding of pregnancy in women on dialysis, and can lead to better counseling and shared decision making. Background Pregnancy in women with ESKD undergoing dialysis is uncommon due to impaired fertility. Data on pregnancy in women on dialysis in the United States is scarce. Methods We evaluated a retrospective cohort of 47,555 women aged 15–44 years on dialysis between January 1, 2005 and December 31, 2013 using data from the United States Renal Data System with Medicare as primary payer. We calculated pregnancy rates and identified factors associated with pregnancy. Results In 47,555 women on dialysis, 2352 pregnancies were identified. Pregnancy rate was 17.8 per thousand person years (PTPY) with the highest rate in women aged 20–24 (40.9 PTPY). In the adjusted time-to-event analysis, a higher likelihood of pregnancy was seen in Native American (HR, 1.77; 95% CI, 1.33 to 2.36), Hispanic (HR, 1.51; 95% CI, 1.32 to 1.73), and black (HR, 1.33; 95% CI, 1.18 to 1.49) women than in white women. A higher rate of pregnancy was seen in women with ESKD due to malignancy (HR, 1.64; 95% CI, 1.27 to 2.12), GN (HR, 1.38; 95% CI, 1.21 to 1.58), hypertension (HR, 1.32; 95% CI, 1.16 to 1.51), and secondary GN/vasculitis (HR, 1.18; 95% CI, 1.02 to 1.37) than ESKD due to diabetes. A lower likelihood of pregnancy was seen among women on peritoneal dialysis than on hemodialysis (HR, 0.47; 95% CI, 0.41 to 0.55). Conclusions The pregnancy rate is higher in women on dialysis than previous reports indicate. A higher likelihood of pregnancy was associated with race/ethnicity, ESKD cause, and dialysis modality.
TCT-703 Outcomes Following Aortic Valve Replacement for Cardiogenic Shock: Transcatheter Versus Surgical Approaches
Authors: Samuel Maidman, John Lisko, Norihiko Kamioka, Isida Byku, Patrick Gleason, Lucia Alvarez, Kendra Grubb, Toby Rogers, Jaffar Khan, Robert Guyton, Vasilis Babaliaros, Chandan Devireddy
Journal: Journal of the American College of Cardiology (2019)
The Performance of the Original and Simplified Wells Scores in Combination with Age-Adjusted D-Dimer Testing in the Diagnostic Management of Pulmonary Embolism
Authors: Noémie Kraaijpoel, Nick van Es, Harry R Büller, Frederikus A Klok, Menno V Huisman, Paul L den Exter, Javier Galipienzo, Saskia Middeldorp, Patrick M Bossuyt
Journal: Blood (2016)
Clathrin switches transforming growth factor-β role to pro-tumorigenic in liver cancer
Authors: Daniel Caballero-Díaz, Esther Bertran, Irene Peñuelas-Haro, Joaquim Moreno-Càceres, Andrea Malfettone, Judit López-Luque, Annalisa Addante, Blanca Herrera, Aránzazu Sánchez, Ania Alay, Xavier Solé, Teresa Serrano, Emilio Ramos, Isabel Fabregat
Journal: Journal of Hepatology (2019)

Upon ligand binding, tyrosine kinase receptors, such as epidermal growth factor receptor (EGFR), are recruited into clathrin-coated pits for internalization by endocytosis, which is relevant for signalling and/or receptor degradation. In liver cells, transforming growth factor-β (TGF-β) induces both pro- and anti-apoptotic signals; the latter are mediated by the EGFR pathway. Since EGFR mainly traffics via clathrin-coated vesicles, we aimed to analyse the potential role of clathrin in TGF-β-induced signalling in liver cells and its relevance in liver cancer.Real-Time PCR and immunohistochemistry were used to analyse clathrin heavy-chain expression in human (CLTC) and mice (Cltc) liver tumours. Transient knockdown (siRNA) or overexpression of CLTC were used to analyse its role on TGF-β and EGFR signalling in vitro. Bioinformatic analysis was used to determine the effect of CLTC and TGFB1 expression on prognosis and overall survival in patients with hepatocellular carcinoma (HCC).Clathrin expression increased during liver tumorigenesis in humans and mice. CLTC knockdown cells responded to TGF-β phosphorylating SMADs (canonical signalling) but showed impairment in the anti-apoptotic signals (EGFR transactivation). Experiments of loss or gain of function in HCC cells reveal an essential role for clathrin in inhibiting TGF-β-induced apoptosis and upregulation of its pro-apoptotic target NOX4. Autocrine TGF-β signalling in invasive HCC cells upregulates CLTC expression, switching its role to pro-tumorigenic. A positive correlation between TGFB1 and CLTC was found in HCC cells and patients. Patients expressing high levels of TGFB1 and CLTC had a worse prognosis and lower overall survival.This work describes a novel role for clathrin in liver tumorigenesis, favouring non-canonical pro-tumorigenic TGF-β pathways. CLTC expression in human HCC samples could help select patients that would benefit from TGF-β-targeted therapy.Clathrin heavy-chain expression increases during liver tumorigenesis in humans (CLTC) and mice (Cltc), altering the cellular response to TGF-β in favour of anti-apoptotic/pro-tumorigenic signals. A positive correlation between TGFB1 and CLTC was found in HCC cells and patients. Patients expressing high levels of TGFB1 and CLTC had a worse prognosis and lower overall survival. CLTC expression in HCC human samples could help select patients that would benefit from therapies targeting TGF-β.
Transcatheter Versus Medical Treatment of Patients With Symptomatic Severe Tricuspid Regurgitation
Authors: Maurizio Taramasso, Giovanni Benfari, Pieter van der Bijl, Hannes Alessandrini, Adrian Attinger-Toller, Luigi Biasco, Philipp Lurz, Daniel Braun, Eric Brochet, Kim A. Connelly, Sabine de Bruijn, Paolo Denti, Florian Deuschl, Rodrigo Estevez-Loureiro, Neil Fam, Christian Frerker, Mara Gavazzoni, Jörg Hausleiter, Edwin Ho, Jean-Michel Juliard, Ryan Kaple, Christian Besler, Susheel Kodali, Felix Kreidel, Karl-Heinz Kuck, Azeem Latib, Alexander Lauten, Vanessa Monivas, Michael Mehr, Guillem Muntané-Carol, Tamin Nazif, Georg Nickening, Giovanni Pedrazzini, François Philippon, Alberto Pozzoli, Fabien Praz, Rishi Puri, Josep Rodés-Cabau, Ulrich Schäfer, Joachim Schofer, Horst Sievert, Gilbert H.L. Tang, Holger Thiele, Yan Topilsky, Karl-Philipp Rommel, Victoria Delgado, Alec Vahanian, Ralph Stephan Von Bardeleben, John G. Webb, Marcel Weber, Stephan Windecker, Mirjam Winkel, Michel Zuber, Martin B. Leon, Rebecca T. Hahn, Jeroen J. Bax, Maurice Enriquez-Sarano, Francesco Maisano
Journal: Journal of the American College of Cardiology (2019)