tbuckley/cabot-search huggingface dataset:
AB1198 DECREASING OF TOTAL AND UNILATERAL KNEE ARTHROPLASTIES DUE TO RHEUMATOID ARTHRITIS BUT INCREASING IN OSTEOARTHRITIS IN OUR INSTITUTES IN LAST DECADE OF SUPER-AGING SOCIETY
Authors: Y. Takakubo, T. Yamamoto, T. Nagase, A. Narita, S. Toyono, A. Suzuki, T. Nakajima, S. Fukushima, M. Takagi
Journal: Annals of the Rheumatic Diseases (2020)

Background: The rate of elderly people over 65 year-old increased from 22.1 % in 2008 to 27.7% in 2017 in Japan, also from 27.1 % to 32.3 % in our super-aging area 1, 2 . The number of total and unilateral knee arthroplasty (TKA, UKA) have increased annually in all over the world according to the larger population of elderly people due to osteoarthritis (OA) 3 . In fact, the numbers of primary TKA predicted increasing from six hundred fifty-six thousand cases at 2010 to one million three hundred seventy-six thousand cases at 2020 in USA 4 . In the other hand, rheumatoid arthritis (RA) therapy have been remarkably improved from starting to use biologic agents since 2003 in Japan 5 . The rate of orthopaedic surgery may reflect trends in disease severity and drug management of RA 5 . Objectives: The aim of study is to reveal the rate of TKA, including UKA and revision TKA in elderly people in our super-aging area of Japan. Methods: We surveyed the number and cause of primary and revision TKA and UKA in our institutes using the data of diagnosis procedure combination and the record of surgeries in the last decade. Results: Figure 1. Table 1. 2008-12 2013-17 Times Osteoarthritis 1565 2252* 1.3 Rheumatoid arthritis 131 81* 0.6 Trauma 1 5 5 Osteonecrosis of femoral condylar 20 41* 2.1 Revision 21 39 1.9 Total 1738 2418* 1.4 * p &lt; 0.05 Conclusion: The number and rate of primary TKA/UKA due to RA decreased year by year because of progression of modern medication therapy. In the other hand, in case of OA increased because of increasing of elderly people affected by knee OA in the super-aging society. References: [1]National Institute of Population and Social Security Research. Japanese Mortality Database, 2018. http://www.ipss.go.jp/ [2]Yamagata prefecture, Health and longevity Promotion Section. Rate of elderly people in Yamagata prefecture, 2018. http://www.pref.yamagata.jp/ou/kikakushinko/020052/tokei/jinkel.html [3]Annual report 2017 of replacement arthroplasty in Japan. The Japanese Society For Replacement Arthroplasty The Japan Arthroplasty Register. https://jsra.info/jar-report.html [4]Kurtz SM, et al. J Bone Joint Surg Am. 96: 624-30, 2014. [5]Momohara S, et al. J Rheumatol. 41:862-5, 2014. Disclosure of Interests: None declared
Mutation of complement factor B causing massive fluid-phase dysregulation of the alternative complement pathway can result in atypical hemolytic uremic syndrome
Authors: Yuzhou Zhang, Robin A. Kremsdorf, C. John Sperati, Kammi J. Henriksen, Mari Mori, Renee X. Goodfellow, Gabriella R. Pitcher, Cindy L. Benson, Nicolo Ghiringhelli Borsa, Ronald P. Taylor, Carla M. Nester, Richard J.H. Smith
Journal: Kidney International (2020)
Intermedin promotes vessel fusion by inducing VE‐cadherin accumulation at potential fusion sites and to achieve a dynamic balance between VE‐cadherin‐complex dissociation/reconstitution
Authors: Lingmiao Kong, Fei Xiao, Lijun Wang, Min Li, Denian Wang, Zhongxue Feng, Luping Huang, Yong'gang Wei, Hongyu Li, Fei Liu, Yan Kang, Xuelian Liao, Wei Zhang
Journal: MedComm (2020)

To create a closed vascular system, angiogenic sprouts must meet and connect in a process called vessel fusion, which is a prerequisite for establishment of proper blood flow in nascent vessels. However, the molecular machinery underlying this process remains largely unknown. Herein, we report that intermedin (IMD), a calcitonin family member, promotes vessel fusion by inducing endothelial cells (ECs) to enter a "ready-to-anchor" state. IMD promotes vascular endothelial cadherin (VEC) accumulation at the potential fusion site to facilitate anchoring of approaching vessels to each other. Simultaneously, IMD fine-tunes VEC activity to achieve a dynamic balance between VEC complex dissociation and reconstitution in order to widen the anastomotic point. IMD induces persistent VEC phosphorylation. Internalized phospho-VEC preferentially binds to Rab4 and Rab11, which facilitate VEC vesicle recycling back to the cell-cell contact for reconstruction of the VEC complex. This novel mechanism may explain how neovessels contact and fuse to adjacent vessels to create a closed vascular system.
Osteoporosis Prevention and Management in Primary Care, by Colin Waine
Authors: C. L K Lam
Journal: BMJ (1997)

Colin Waine / Royal College of General Practitioners, £9.90, pp 24 ISBN 0 85084 233 6

Few people would disagree that osteoporosis is an important health problem that is becoming “the silent epidemic” in the aging world population. Despite the large amount of research on osteoporosis in the past 10 years, there is still uncertainty on the roles of hormone replacement therapy and other treatments in preventing and managing the condition. The large volume of information and the divided opinions among experts can be confusing for doctors in primary care. A concise book that summarises the current knowledge and gives guidelines …
Response to “COVID-19 in persons with haematological cancers”
Authors: Stefan Hatzl, Florian Eisner, Gernot Schilcher, Philipp Kreuzer, Maximilian Gornicec, Philipp Eller, Marianne Brodmann, Peter Schlenke, Martin Helmut Stradner, Robert Krause, Hildegard Greinix, Eduard Schulz
Journal: Leukemia (2020)
Ivosidenib in Isocitrate Dehydrogenase 1<i>–</i>Mutated Advanced Glioma
Authors: Ingo K. Mellinghoff, Benjamin M. Ellingson, Mehdi Touat, Elizabeth Maher, Macarena I. De La Fuente, Matthias Holdhoff, Gregory M. Cote, Howard Burris, Filip Janku, Robert J. Young, Raymond Huang, Liewen Jiang, Sung Choe, Bin Fan, Katharine Yen, Min Lu, Chris Bowden, Lori Steelman, Shuchi S. Pandya, Timothy F. Cloughesy, Patrick Y. Wen
Journal: Journal of Clinical Oncology (2020)

Diffuse gliomas are malignant brain tumors that include lower-grade gliomas (LGGs) and glioblastomas. Transformation of low-grade glioma into a higher tumor grade is typically associated with contrast enhancement on magnetic resonance imaging. Mutations in the isocitrate dehydrogenase 1 (IDH1) gene occur in most LGGs (> 70%). Ivosidenib is an inhibitor of mutant IDH1 (mIDH1) under evaluation in patients with solid tumors.We conducted a multicenter, open-label, phase I, dose escalation and expansion study of ivosidenib in patients with mIDH1 solid tumors. Ivosidenib was administered orally daily in 28-day cycles.In 66 patients with advanced gliomas, ivosidenib was well tolerated, with no dose-limiting toxicities reported. The maximum tolerated dose was not reached; 500 mg once per day was selected for the expansion cohort. The grade ≥ 3 adverse event rate was 19.7%; 3% (n = 2) were considered treatment related. In patients with nonenhancing glioma (n = 35), the objective response rate was 2.9%, with 1 partial response. Thirty of 35 patients (85.7%) with nonenhancing glioma achieved stable disease compared with 14 of 31 (45.2%) with enhancing glioma. Median progression-free survival was 13.6 months (95% CI, 9.2 to 33.2 months) and 1.4 months (95% CI, 1.0 to 1.9 months) for the nonenhancing and enhancing glioma cohorts, respectively. In an exploratory analysis, ivosidenib reduced the volume and growth rates of nonenhancing tumors.In patients with mIDH1 advanced glioma, ivosidenib 500 mg once per day was associated with a favorable safety profile, prolonged disease control, and reduced growth of nonenhancing tumors.
Platinum Opinion Counterview: The Evidence Base for the Benefit of Magnetic Resonance Imaging-directed Prostate Cancer Diagnosis is Sound
Authors: Anwar R. Padhani, Geert Villeirs, Hashim U. Ahmed, Valeria Panebianco, Ivo G. Schoots, Clare M.C. Tempany, Jeff Weinreb, Jelle O. Barentsz
Journal: European Urology (2020)
SP0001 Sense and nonsense in the diagnostic procedures of early rheumatoid arthritis
Authors: M Hazes
Journal: Annals of the Rheumatic Diseases (2001)

<h3></h3> Early arthritis clinics will consist of a very heterogeneous group of arthritis patients, both as to their initial clinical presentation as to their outcome. Dependent on the way patients have been selected, about one third of the patients has a disease that may ultimately classified as rheumatoid arthritis (RA), one third will have another classifiable inflammatory rheumatic disorder and one third of the patients remains unclassified. The diagnosis or classification of RA is based on the presence of a distinct clinical entity that needs a certain amount of time to develop. The classification criteria for RA are therefore not very suitable for early diagnosis. In addition, there is a certain circularity in using the ACR criteria as gold standard to diagnose RA early in the disease course. The essence of RA diagnosis or RA classification is the presence of a persistent and destructive polyarthritis. In early arthritis we are not dealing with an already existing disease entity that can be classified as RA, but we are confronted with a very heterogeneous patient population. At that stage we would like to predict which patients will have a self-limiting arthritis, a persistent non-erosive arthritis or a persistent erosive arthritis. At present Ig-M rheumatoid factor (RF) appears to be the most powerful single predictor of persistent erosive arthritis. Apart from genetic markers, many clinical and laboratory parameters at the beginning of the disease have been found more or less predictive of severe erosive arthritis, including active polyarthritis, high scores of disease activity measurements, involvement of at least two large joints, different serological markers such as the anti-perinuclear factor (APF) and anti-citrulline antibodies (Anti-CCP, "AKA"), initial HAQ score and initial radiological score. None of these variables is powerful enough though, to predict the presence of persistent erosive arthritis as a single predictor. Analysis of the Leiden Early Arthritis Cohort data showed that, looking at all potentially predictive determinants obtained from patient history, physical examination, serological and genetic markers, an optimal criteria set of 7 variables consisting of symptom duration, morning stiffness &gt;1 h, arthritis of 3 or more joints, bilateral compression pain of metatarsophalangeal joints, RF positivity, anti-cyclic citrullinated peptide antibody positivity and the presence of erosions could successfully discriminate between self-limiting, persistent non-erosive and erosive arthritis. The predictive model could be simplified to provide predictive probabilities at the individual patient level. The overall diagnostic/prognostic performance of the 1987 ACR classification criteria was significantly lower than the criteria set described above. The utility of (a combination of) diagnostic/predictive parameters has to be judged against the background of the patient population in which the criteria have been developed.
Animal models of psoriasis—highlights and drawbacks
Authors: Michael P. Schön, Veit Manzke, Luise Erpenbeck
Journal: Journal of Allergy and Clinical Immunology (2020)

Research into the pathophysiology of psoriasis remains challenging, because this disease does not occur naturally in laboratory animals. However, specific aspects of its complex immune-pathology can be illuminated through transgenic, knockout, xenotransplantation, immunological reconstitution, drug-induced, or spontaneous mutation models in rodents. Although some of these approaches have already been pursued for more than 5 decades and even more models have been described in recent times, they have surprisingly not yet been systematically validated. As a consequence, researchers regularly examine specific aspects that only partially reflect the complex overall picture of the human disease. Nonetheless, animal models are of great utility to investigate inflammatory mediators, the communication between cells of the innate and the adaptive immune systems, the role of resident cells as well as new therapies. Of note, various manipulations in experimental animals resulted in rather similar phenotypes. These were called "psoriasiform", "psoriasis-like" or even "psoriasis" usually on the basis of some similarities with the human disorder. Xenotransplantation of human skin onto immunocompromised animals can overcome this limitation only in part. In this review, we elucidate approaches for the generation of animal models of psoriasis and assess their strengths and limitations with a certain focus on more recently developed models.
Abstract 15093: Impact of 2017 American Heart Association Guidelines on Cardiac Telemetry Utilization: Study From a Tertiary Medical Center
Authors: Anusha G Bhat, Ryan Quarles, Kanval Shah, Lisa Demko, Sandeep Muddasani, Kathleen Mahoney, Lotfi Amir, Joseph Schmidt, Alicia Meacham, Crystal Wilson, Carlo Reale, Mihaela Stefan
Journal: Circulation (2019)

Introduction: In October 2017, American Heart Association (AHA) updated their practice standards regarding cardiac telemetry. The Choosing Wisely campaign has adopted these guidelines to optimize t...
Poster Session 2: Acute Liver Failure
Journal: Hepatology (2014)

Background: Acute-on-chronic liver failure (ACLF) is defined differently between Eastern (APASL) and Western countries (EASL-CLIF).This study aimed to investigate the prevalence of ACLF according to the APASL vs. EASL-CLIF definitions as well as short-term mortality and associated factors in patients with acute decompensation (AD).Methods: We collected data for 1022 hospitalized patients (male 756, median age 55±12 years) with chronic liver disease (CLD) and AD from January 2013 to December 2013 from 16 academic hospitals in Korea.The Kaplan-Meier method with log-rank test was used to calculate short term mortality (28-day and 90-day).Results: The most common underlying cause of CLD was alcohol (63.3%) and the main forms of AD were variceal bleeding (29.2%), more than one events (20.3%), and ascites (17.2%).The prevalence of ACLF development based on the APASL and EASL-CLIF definitions were 158 (15.5%) and 132 (12.9%) at admission, and 69 (6.8%) and 41 (4.0%) within 28 days of enrollment, respectively.The 28-day and 90-day mortality were higher in patients with ACLF at enrollment than in those without ACLF at enrollment (by APASL definition: 18.4% vs. 4.6%, and 29.5% vs. 8.6%, respectively, P < 0.001; by EASL-CLIF definition: 27.3% vs. 3.7%, and 41.7% vs. 7.8%, respectively, P < 0.001).At the time of admission, of the 242 patients who satisfied the APASL or EASL-CLIF definition, only 48 (19.8%) patients satisfied both definitions, while the remaining patients (81.2%) satisfied only one (with APASL definition, 110 patients; with EASL-CLIF definition, 84 patients).In patients with ACLF, the 28-day and 90-day mortality in patients who satisfied both definitions were higher than in those who satisfied just one definition (45.8% and 51.3%, respectively).Patients with ACLF by the APASL definition were significantly different from those defined by the EASL-CLIF definition in terms of patient characteristics, including higher bilirubin, lower creatinine, frequent ascites, less frequent encephalopathy, higher Child-Pugh score, and lower CLIF-SOFA score.Conclusions: The development of ACLF is associated with high short-term mortality.However, patient characteristics are significantly different when ACLF is defined by the two different APASL vs. EASL-CLIF definitions.Thus refinement of the two ACLF definitions or a consensus definition is urgently needed.
연구논문 : 만성 B형간염 환자에서 hepatitis B core antigen의 발현과 분포 위치에 따른 라미부딘의 치료 반응
Authors: 시계동 ( Kyeh Dong Shi ), 황성규 ( Seong Gyu Hwang ), 최주현 ( Ju Hyun Choi ), 황일준 ( Il Joon Hwang ), 윤재호 ( Jai Ho Yoon ), 김광일 ( Kwang Il Kim ), 권창일 ( Chang Il Kwon ), 홍성표 ( Suang Pyo Hong ), 박필원 ( Pil Won Park ), 임규성 ( Kyu Suang Rim )
Journal: Clinical and Molecular Hepatology (2008)
Coronary 18F-Sodium Fluoride Uptake Predicts Outcomes in Patients With Coronary Artery Disease
Authors: Jacek Kwiecinski, Evangelos Tzolos, Philip D. Adamson, Sebastien Cadet, Alastair J. Moss, Nikhil Joshi, Michelle C. Williams, Edwin J.R. van Beek, Damini Dey, Daniel S. Berman, David E. Newby, Piotr J. Slomka, Marc R. Dweck
Journal: Journal of the American College of Cardiology (2020)
Comparing the Roles of Omalizumab and UV Therapy in Treating Severe Pediatric Atopic Dermatitis—Reply
Authors: Susan Chan, Gideon Lack
Journal: JAMA Pediatrics (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
THU0353 ENDOCAN AND CIRCULATING PROGENITOR CELLS IN SYSTEMIC SCLEROSIS: ASSOCIATION WITH PULMONARY HYPERTENSION
Authors: A. Lo Gullo, D. Sinicropi, M. Cinquegrani, F. Savarino, C. Giuffrida, G. Squadrito, G. Mandraffino
Journal: Annals of the Rheumatic Diseases (2020)

Background: Systemic sclerosis (SSc) is characterized by early vascular involvement and by varying degrees of fibrosis in skin, lungs, and other tissues. Vascular manifestations include Raynaud’s phenomenon, digital ulcers, and pulmonary hypertension (PAH). The prevalence of PAH is 7.85–13% in SSc and it is the second most common cause of mortality in SSc. Circulating CD34+ cell number is associated to cardiovascular health status in several chronic conditions, including inflammatory disease. CD34+ cell number was found inconstantly reduced in SSc. Endocan is a proteoglycan expressed by endothelial cells likely interacting with white blood cells, recently suggested as a marker of vascular stress. Objectives: to evaluate CD34+ cell number and endocan as a markers od cardiovascular involvement in SSc. Methods: Standard transthoracic echocardiography, Rodnan skin score were performed. Vitamin D levels, CD34+ cell number, markers of inflammation, red blood cells distribution width (RDW) and Endocan plasma levels were also determined. Results: 37 female SSc patients (11 diffuse/26 limited) and 35 matched healthy controls (HC) were enrolled. CD34+ cell count was lower as compared to controls (2.3±0.73 vs 2.9±0.6; p&lt;0.001), CRP and ESR were significantly higher in SSc patients than controls. Vitamin D3 was lower in SSc patients with respect to controls (18±4.5 vs 27.26±10.98; p&lt;0.001), Rodnan skin score was 28.89±10.24. Endocan was two times greater than controls and serum endocan levels were higher in patients with diffuse Ssc as compared with limited ones. We found no correlation between Endocan and: Rodnan skin score, ESR, fibrinogen; we found a trend of correlation between Endocan and Vitamin D levels (r= -0.315), RDW (r= 0.310), CRP (r= 0.310), but statistical significance was not reached likely due to the small sample size. We found an association of PAPs with Endocan levels (rho= 0.442, p&lt;0.01) and CD34+ count (-0.349, p&lt;0.05. A significant correlation was also found between Endocan and CD34+ cell number (rho= -0.605, p&lt;0.01). Conclusion: In our study population, we found a significant correlation between CD34+ cell number and Endocan plasma levels and PAPs; Endocan and CD34+ progenitor cells might be suggested as potential marker of pulmonary arterial hypertension in SSc patients. References: [1]Lo Gullo et al. Atherosclerosis 2018 Disclosure of Interests: Alberto Lo Gullo Speakers bureau: bayer, Davide Sinicropi: None declared, Mara Cinquegrani: None declared, Francesca Savarino: None declared, Clemente Giuffrida: None declared, Giovanni Squadrito: None declared, Giuseppe Mandraffino: None declared
Humidity‐Triggered Relaxation of Polyelectrolyte Complexes as a Robust Approach to Generate Extracellular Matrix Biomimetic Films
Authors: Jing Wang, Yun‐Fan Xue, Xia‐Chao Chen, Mi Hu, Ke‐Feng Ren, Jian Ji
Journal: Advanced Healthcare Materials (2020)

Generating a biofunctional film that can mimic the extracellular matrix (ECM) in an efficient and robust technique that may have great potential for medical devices, tissue engineering, and regenerative medicines. Herein, a facile approach to generate ECM biomimetic films based on the humidity-triggered relaxation of polyelectrolyte complex (PEC) nanoparticles is reported. The poly(l-lysine) and hyaluronan are precomplexed and sprayed onto a substrate, which, via a trigger of vaporous water, can be transformed into an even and stable film. The spontaneous polymer chain interfusion (diffusion coefficient ≈1.01 × 10-9 cm2 s-1 ) under saturated humidity, allowing for the rapid reorganization (within 30 min) of film morphology and structure is demonstrated. A controllable and scalable way for the loading of diversified bioactive agents, as well as on-demand modulation of stiffness is further presented. Moreover, the high-throughput arrays and programmed patterns can be easily completed, suggesting huge potentials that surpass those of state-of-the-art methods. Combined with high efficiency and flexible functionalization, it is believed that this approach should be beneficial for extending the practical applications of PEC films, such as medical implants, chip detectors, and so on.
Diagnostic and therapeutic differences between immune checkpoint inhibitor‐induced and idiopathic bullous pemphigoid: a cross‐sectional study
Authors: G.E. Molina, K.L. Reynolds, S.T. Chen
Journal: British Journal of Dermatology (2020)

Bullous pemphigoid (BP) is a serious, rare complication from immune checkpoint inhibitors (ICIs). While most dermatologic immune-related adverse events (irAEs) present early and are mild, ICI-induced BP (ICI-BP) manifests months into therapy and can prompt ICI discontinuation and severe immunosuppression. Following irAE management guidelines, providers rely on systemic corticosteroids - which, at high doses, may confer poorer oncologic outcomes for ICI patients. Our study aims to identify diagnostic and therapeutic differences between ICI-BP and idiopathic BP (iBP) to assist providers in prompt recognition and management of this skin toxicity.