tbuckley/cabot-search huggingface dataset:
Insights into the Evolution of the Suppressors of Cytokine Signaling (SOCS) Gene Family in Vertebrates
Authors: Bei Wang, Eakapol Wangkahart, Christopher J Secombes, Tiehui Wang
Journal: Molecular Biology and Evolution (2018)

The SOCS family are key negative regulators of cytokine and growth factor signaling. Typically, 8-17 SOCS genes are present in vertebrate species with eight known in mammals, classified as type I (SOCS4-7) and type II (CISH and SOCS1-3) SOCS. It was believed that the type II SOCS were expanded through the two rounds of whole genome duplication (1R and 2R WGDs) from a single CISH/SOCS1-3 precursor. Previously, 12 genes were identified in rainbow trout but here we report 15 additional loci are present, and confirm 26 of the genes are expressed, giving rainbow trout the largest SOCS gene repertoire identified to date. The discovery of the additional SOCS genes in trout has led to a novel model of SOCS family evolution, whereby the vertebrate SOCS gene family was derived from CISH/SOCS2, SOCS1/SOCS3, SOCS4/5, SOCS6, and SOCS7 ancestors likely present before the two WGD events. It is also apparent that teleost SOCS2b, SOCS4, and SOCS5b molecules are not true orthologues of mammalian SOCS2, SOCS4, and SOCS5, respectively. The rate of SOCS gene structural changes increased from 2R vertebrates, to 4R rainbow trout, and the genes with structural changes show large differences and low correlation coefficient of expression levels relative to their paralogues, suggesting a role of structural changes in expression and functional diversification. This study has important impacts in the functional prediction and understanding of the SOCS gene family in different vertebrates, and provides a framework for determining how many SOCS genes could be expected in a particular vertebrate species/lineage.
Health-Related Quality of Life Outcomes in Newly Diagnosed Chronic Myeloid Leukemia Patients Treated with Dasatinib and Low Dose Pegylated Interferon
Authors: Henrik Hjorth-Hansen, Satu Mustjoki, Ulla Olsson-Strömberg, Jesper Stentoft, Fabio Efficace, Hemming Johansson, Yvonne Brandberg
Journal: Blood (2018)
Interferon alfa‐2a maintenance after salvage autologous stem cell transplantation in atypical mycosis fungoides with central nervous system involvement
Authors: M. Doerschner, A. Pekar‐Lukacs, O. Messerli‐Odermatt, C. Dommann‐Scherrer, M. Rütti, A.M. Müller, G. Nair, J. Kamarachev, K. Kerl, M. Beer, M. Messerli, K. Frauenknecht, E. Haralambieva, W. Hoetzenecker, L.E. French, E. Guenova
Journal: British Journal of Dermatology (2018)

Mycosis fungoides (MF) is a primary cutaneous T‐cell lymphoma with unfavourable prognosis for patients with advanced stages of the disease. Refractory disease and advanced‐stage disease require systemic therapy. We report on a rare case of an atypical predominantly CD8+ folliculotropic MF, a subtype of MF with poorer prognosis, in a 59‐year‐old woman. She was initially diagnosed with MF restricted to the skin, of T3N0M0B0/stage IIB according to the current World Health Organization–European Organisation for Research and Treatment of Cancer classification. First‐line treatment with local percutaneous radiotherapy in combination with systemic interferon alfa‐2a resulted in complete remission. However, 21 months later the disease progressed to T3N0M1B0/stage IVB with development of cerebral manifestation and thus very poor prognosis. Allogeneic stem cell transplantation (SCT) was not a therapeutic option due to the lack of a suitable donor. We initiated methotrexate and cytarabine chemotherapy, followed by high‐dose chemotherapy with thiotepa and carmustine with autologous SCT. Despite rapid response and complete remission of the cerebral lesions, disease recurrence of the skin occurred soon after. Interestingly, readministration of interferon alfa‐2a as a maintenance treatment after the salvage autologous SCT resulted in a durable complete remission during the follow‐up period of currently 17 months after autologous SCT. What's already known about this topic? Mycosis fungoides is a primary cutaneous T‐cell lymphoma with unfavourable prognosis for the advanced stages of the disease. A refractory course of disease requires systemic therapy. What does this study add? We report on an unusual case of a patient with mycosis fungoides with cerebral involvement, in which a durable complete remission was achieved upon autologous stem cell therapy and interferon alfa‐2a maintenance therapy.
Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1–SOX2 positive-feedback loop
Authors: Jun Wang, Sen-Lin Xu, Jiang-Jie Duan, Liang Yi, Yu-Feng Guo, Yu Shi, Lin Li, Ze-Yu Yang, Xue-Mei Liao, Jiao Cai, Yan-Qi Zhang, Hua-Liang Xiao, Li Yin, Hao Wu, Jing-Na Zhang, Sheng-Qing Lv, Qing-Kai Yang, Xiao-Jun Yang, Tao Jiang, Xia Zhang, Xiu-Wu Bian, Shi-Cang Yu
Journal: Nature Neuroscience (2018)
Reverse rendezvous with endoscopic retrograde cholangiography and percutaneous transhepatic cholangio drainage: who meets whom?
Authors: Martin Goetz, Jakob Fisch, Jürgen Hetzel, Gerd Grözinger
Journal: Endoscopy (2018)

A 47-year-old severely ill Caucasian man presented with cholestasis (bilirubin 17.8 mg/dL) due to primary sclerosing cholangitis. Endoscopic retrograde cholangiography (ERC) showed high grade strictures of the common bile duct (CBD), dilation of the common hepatic duct (CHD), and left hilar obstruction ([Fig. 1 a]). Attempts to maneuver 5 – 7-Fr bougies across the distal CBD stenosis were not successful.
Development and evaluation of a pan‐dermatophyte polymerase chain reaction with species‐level identification using sloppy molecular beacon probes
Authors: M. Walser, P.P. Bosshard
Journal: British Journal of Dermatology (2018)

Conventional laboratory diagnosis of dermatophyte infection is cumbersome and time‐consuming. We aimed to establish a simple, robust and rapid molecular diagnostic assay for the detection of dermatophytes and optionally nondermatophytes in clinical specimens. We developed a two‐tube pan‐dermatophyte polymerase chain reaction (PCR) assay using six sloppy molecular beacon (SMB) probes. The first PCR uses dermatophyte‐specific primers and enables detection and identification of most dermatophyte species. The second PCR with pan‐fungal primers allows further differentiation of Trichophyton interdigitale and T. mentagrophytes/T. quinckeanum, T. violaceum and T. soudanense, and T. tonsurans and T. equinum, and detection of nondermatophytes. The test was evaluated with 306 clinical specimens by comparing it with the results of microscopy and culture. In melting‐curve analyses, species‐specific melting temperature signatures of the SMBs were defined, and thus, our new PCR enabled detection and species‐level identification of at least 19 dermatophyte species. Sensitivity and specificity of PCR for detection of dermatophytes in clinical samples were estimated to be 96·9% and 90·4%, for culture 46·7% and 98·7%, and for microscopy 91·4% and 84·0%, respectively. The detection of nondermatophytes by PCR and culture did not correlate. The new assay showed excellent performance characteristics for the detection of dermatophytes and is significantly faster than culturing techniques, which makes it very promising for routine diagnostics of dermatophytosis. We noted that the detection of nondermatophytes in our assay currently has no benefit.
Stephen John Greenhill Semple
Authors: Martyn R Partridge
Journal: BMJ (2018)

Stephen John Greenhill Semple (“Steve”) was professor of medicine at various times at several medical schools in London, but he will be remembered best for his time as professor of medicine and head of the department of medicine at the Middlesex Hospital School of Medicine (and subsequently head of the department of medicine in the joint School of Medicine of University College and the Middlesex Hospital School of Medicine). He had moved to the Middlesex after a year as a professor of medicine at his alma mater, St Thomas’ Hospital Medical School, in 1969-70. After leaving the Middlesex-UCH on reaching retirement age he became visiting professor of medicine to the Charing Cross and Westminster School of Medicine, and subsequently professor emeritus of medicine at Imperial College London.

Educated at Westminster School, Steve …
AB1390 Osteoporosis associated morbidity analysis can reveal targets for better disease diagnosis and management
Authors: L. Chicea
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Osteoporosis accounts for more disability and life years lost than rheumatoid arthritis. It brings an elevated risk of mortality, morbidity and re-/hospitalisation due to fractures and a significant financial and social burden. A rationale use of diagnostic and therapeutic resources is useful and should be encouraged at all intervention levels. For admitted patients, clinical risk factors for fractures and conditions that are causes for secondary osteoporosis should trigger either the diagnosis approach or the referral to a (Rheumatology/Endocrinology) specialist and treatment should be started during hospitalisation. <h3>Objectives</h3> We aimed to identify targets for educational or protocol interventions in order to improve inpatient osteoporosis diagnosis and subsequent management. <h3>Methods</h3> A retrospective three years (2014–2016) cross-sectional prevalence analysis of comorbidities in all hospitalised patients with osteoporosis in our general hospital was conducted. We used the medical records database of our hospital. <h3>Results</h3> Osteoporosis as a principal diagnosis was found in 46 cases, mostly from the Endocrinology Department (65%). Osteoporosis as a secondary diagnosis was found in 2464 cases, and only 11% were diagnose-associated with fractures. 23% of all comorbidities are of endocrine or diabetic etiology. A small percent of osteoporosis cases have simultaneous skeletal disease, mostly vertebral fractures, osteomalacia or degenerative disease. Only 8,77% of secondary osteoporosis was diagnosed in the Orthopaedic Department. No osteoporosis was mentioned in association with COPD or oncologic disease. Only 65% of patients leaving the hospital had specific recommendation for anti-osteoporotic medication. <h3>Conclusions</h3> Osteoporosis should be mentioned in all cases in the patients medical records that are further sent to the general practitioner. Osteoporosis may be better diagnosed in diabetic, oncologic, COPD, Parkinson disease patients and in a large percent of fracture patients if internal referral protocols will be implemented. Appropriate therapy should be recommended from the hospital specialists. <h3>References</h3> [1] Vranken L et all. The Phenotype of Patients with a Recent Fracture: A Literature Survey of the Fracture Liaison Service. Calcif Tissue Int (2017)101:248–258 [2] Briggs AM et all. Hospitalisations, admission costs and re-fracture risk related to osteoporosis in Western Australia are substantial: a 10-year review. Aust N Z J Public Health. 2015Dec;39(6):557–62. [3] Svedbom A et all. Epidemiology and economic burden of osteoporosis in Switzerland. Arch Osteoporos. 2014;9:187. [4] Kanis J.A. European Guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporosis Int (2013) 24, 23–57. <h3>Disclosure of Interest</h3> None declared
Positive Psychology: A Personal History
Authors: Martin E.P. Seligman
Journal: Annual Review of Clinical Psychology (2018)

As president of the American Psychological Association in 1998, I organized researchers and practitioners to work on building well-being, not just on the traditional task of reducing ill-being. Substantial research then found that well-being causes many external benefits, including better physical and mental health. Among the applications of Positive Psychology are national psychological accounts of well-being, Positive Psychotherapy, the classification of strengths and virtues, Comprehensive Soldier Fitness, and Positive Education. Positive Psychology has spread beyond psychology into neuroscience, health, psychiatry, theology, and even to the humanities. Positive Psychology has many critics, and I comment on the strongest criticisms. I conclude with the hope that the building of well-being will become a cornerstone of morality, politics, and religion.
Abstract P184: Occupation Type, Hypertension Status and Awareness Among Hispanic/Latino Adults: Findings From the Hispanic Community Health Study/ Study of Latinos (HCHS/SOL)
Authors: Natalya Rosenberg, Kamal Eldeirawi, Ramon Durazo-Arvizu, James Lash, Earle Chambers, Sonia Davis, Hector Gonzalez, Krista Perreira, Neil Schneiderman, Wassim Tarraf, Martha Daviglus
Journal: Circulation (2017)

Introduction: Occupation types, e.g. service, have been associated with hypertension (HTN). Data from Hispanics/Latinos are limited, despite high rates of HTN-related morbidity. We examined prevalence of HTN status and awareness by occupation type and association of occupation type with HTN status among Hispanic/Latino adults. Methods: Baseline data from HCHS/SOL, a cohort of diverse Hispanics/Latinos ages 18-74 in 2008-11, were used. Participants (N=7,429, mean age 38.9 years) reported current occupation (definition in Table). HTN was defined as elevated blood pressure (≥ 140/≥90 mm Hg) or self-reported use of antihypertensives; HTN awareness as self-reported physician diagnosed HTN. Survey statistical analyses were weighted and stratified by sex. Effect modification by years in the US, language and social acculturation was tested. Results: Non-skilled worker was the most common occupation type (males 30.1%; females 25.3%). Age-adjusted prevalence of HTN was highest in service workers (males 20.7%; females 17.4%); lowest in non-skilled workers (males 15.5 %; females 14.2%). The prevalence of HTN awareness was lowest in non-skilled male workers (48.2%); highest in females in higher status occupations (76.8%). The association of occupation type with HTN status varied by social acculturation (i.e. preferred ethnicity of social relations). In males, service workers with low social acculturation (preferred Hispanic/Latino social relations) had lower odds of HTN compared to those in higher status occupations, while service or skilled workers with high social acculturation had higher odds of HTN. Female non-skilled workers with low social acculturation had higher odds of HTN compared to higher status occupations (Table). Conclusions: Among Hispanics/Latinos, prevalence of HTN status and awareness varies by occupation type. Occupation type and social acculturation are jointly associated with HTN status. Strategies for HTN prevention and awareness should take into account occupational differences.
Abstract 17236: Comparative Analysis of Cerebrovascular Resistance in the Fetus with Single Ventricle Type of Congenital Heart Disease
Authors: Anita Szwast, Zhiyun Tian, Margaret McCann, Debbra Soffer, Jack Rychik
Journal: Circulation (2010)

Background: Fetuses with hypoplastic left heart syndrome (HLHS) have altered blood flow patterns to the brain when compared to normal. Whether these findings are also present in other forms of comp...
Flash glucose monitoring devices: CCG criteria are incoherent
Authors: Stephen Black
Journal: BMJ (2018)

The incoherent criteria written by clinical commissioning groups (CCGs) for access to FreeStyle Libre are far more worrying than the resulting postcode lottery as they will severely damage our ability to make better decisions in the future.1

Few of the criteria make any sense. They look like a set of clinical excuses cooked up after a financial decision to prescribe FreeStyle Libre as little as possible. …
Use of Combination Systemic-Intratumoral HPV Vaccine to Treat Cutaneous Basaloid Squamous Cell Carcinomas—Reply
Authors: Anna J. Nichols, Robert S. Kirsner, Tim Ioannides
Journal: JAMA Dermatology (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Abstract 18975: Patient Centered Outcomes Research Priorities for Heart Failure and Kawasaki Disease: An Online Consensus Panel of Patients, Clinicians, and Researchers
Authors: Katherine K Kim, Dmitry Khodyakov, Paul A Heidenreich, Michael K Ong, Jane C Burns
Journal: Circulation (2017)

Introduction: Engagement of patients and clinicians is critical to generating evidence that is relevant to their concerns and values. There is meager understanding of optimal engagement for person-...
Abstract 20395: Effects of Antiarrhythmic Drug Therapy Before and During Atrial Fibrillation Ablation on Procedure Outcomes: Results From a European Registry
Authors: Evgeny N Mikhaylov, Nikolaos Dagres, Josep Brugada, Aldo Maggioni, Luigi Tavazzi, Cecile Laroche, Viviane Missiamenou, Elin Folkesson Lefrancq, Anna Patsouk, Dmitry Lebedev, Josef Kautzner, Carina Blomstrom-Lundqvist, Evgeny Pokushalov, Elena Arbelo
Journal: Circulation (2017)

Introduction: Atrial electrophysiology changes induced by antiarrhythmic drugs (AAD) might have an impact on conduction block achievement during AF catheter ablation (AFA) and the extent of ablatio...
Abstract 12: What Is the Optimum Preload Following Lethal Hemorrhagic Shock: Low-Volume Resuscitation---Less Is More
Authors: Christopher L Clancy, Dalun Tang, William A Olorunto, Andrew B Casabianca, Mallory Williams, Gerald B Zelenock, David C Allison, Kay Langenderfer, Andrea L Kalinoski
Journal: Circulation (2012)

Introduction: We have tested whether improved outcomes occur with limited fluid volumes in a small animal model of hemorrhagic shock. Methods: We placed carotid and femoral artery lines into 439 anesthetized, male Sprague Dawley rats. Rats were bled over 5 minutes to a targeted mean arterial pressure (MAP) of 30 mm Hg and maintained at this MAP for one hour by the withdrawal or replacement of heparinized blood. Animals surviving the one hour shock period were randomly assigned into six fluid groups and a no resuscitation control group. Resuscitation fluids were infused over ten minutes at 3:1 and 1:1 fluid to shed blood ratios. Resuscitated rats were observed for 2 hours, and the times to stop breathing, cessation of pulse, and MAPs recorded. M mode echocardiography was performed before instrumentation, ½ hour into shock, and 1 hour into resuscitation to determine end diastolic length (EDL), a marker of preload, and shortening fraction (SF), a marker of contractility. Data were analyzed by chi square anal...
P044 Cost-Effectiveness Analysis of Icotinib vs Whole-Brain Irradiation in NSCLC Patients with Brain Metastases
Authors: W. Li, R. Bai, L. Qian, N. Chen, Y. Zhao, F. Han, L. Bai, J. Li, Y. Yu, J. Cui
Journal: Journal of Thoracic Oncology (2018)
Deep Learning in Medicine—Promise, Progress, and Challenges
Authors: Fei Wang, Lawrence Peter Casalino, Dhruv Khullar
Journal: JAMA Internal Medicine (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Abstract 13846: Telephone CPR is Independently Associated With an Increase in Initial Shockable Rhythms in Patients With Out-of-Hospital Cardiac Arrest
Authors: Micah Panczyk, John Sutter, Blake Langlais, Chengcheng Hu, Tyler F Vadeboncoeur, Terry Mullins, Daniel W Spaite, Bentley J Bobrow
Journal: Circulation (2016)

Background: Bystander CPR (BCPR) and telephone CPR (TCPR) are associated with improved OHCA outcomes. It has been shown that BCPR increases the proportion of patients with an initial shockable cardiac rhythm (VF/VT) when encountered by EMS. It is unknown whether TCPR does the same. Objective: To assess whether TCPR is independently associated with an increase in initial shockable cardiac rhythms during OHCA. Methods: Data from 9-1-1 audio recordings, first care EMS reports and hospital records were linked for OHCAs of presumed cardiac origin (1/2011-12/2014). Three cohorts were analyzed: TCPR, BCPR or no CPR. Using no CPR as the reference group, we assessed whether TCPR and BCPR were independently associated with initial shockable rhythms in a logistic regression model controlling for gender, event location, witness status and EMS response interval. Results: After exclusions, 2715 adult OHCA events with linked outcome data were analyzed (median age: 63; male: 66.8%; 33.3% witnessed arrest). Median response interval was 5 min. The BCPR rate (lay rescuer CPR without telephone instructions) was 24.8% and survival in this group was 15.4%. The TCPR rate (lay rescuer CPR with telephone instructions) was 40.2% and survival in this group was 11.7%. For the no-CPR group, 20.5% had an initial shockable rhythm. For the BCPR group, 34.6 % had an initial shockable rhythm. For the TCPR group, 23.2% had an initial shockable rhythm. Provision of BCPR and of TCPR were each independently associated with shockable rhythms [aOR (BCPR) = 1.7, 95% CI: 1.33-2.17, p=0.0001; aOR (TCPR) = 1.3, 95% CI: 1.04-1.63, p=0.0001]. Conclusion: The provision of both BCPR and TCPR were independently associated with an increased rate of initial shockable cardiac rhythms and an increase in survival to hospital discharge compared to no CPR.