tbuckley/cabot-search huggingface dataset:
ASSESSMENT OF THE APPROPRIATENESS OF COLONOSCOPY IN AN OPEN ACCESS ENDOSCOPY UNIT: REFUSE OF INADEQUATE ONES AND PRIORITIZATION OF THOSE ACCEPTED
Authors: PD Redondo, HN Rodriguez, JT Tejada, EF Valenzuela, R Nájera, M Pérez-Miranda
Journal: Endoscopy (2020)

However there are few publications describing tools to reduce the realization of CSs non-adherents with the clinical guidelines.
COMPARATIVE STUDY OF SURGICAL AND ENDOSCOPIC TREATMENT FOR EARLY GASTROESOPHAGEAL JUNCTION CANCERS
Authors: IM de Sá, A Laranjo, D Libânio, M Areia, P Pimentel Nunes, M Dinis Ribeiro
Journal: Endoscopy (2020)

Aims Gastroesophageal junction (GEJ) cancers have increased in incidence. Early GEJ cancers may be submitted both to endoscopic or surgical treatment, depending on staging and patients’ preferences and risks. However, there are no studies comparing endoscopic and surgical treatment of early GEJ cancers. We aimed to compare the efficacy and safety of endoscopic and surgical treatment.
Cardiac Resuscitation in the Community
Authors: Mickey S. Eisenberg
Journal: JAMA (1979)

Several time-related variables involving resuscitation from out-of-hospital cardiac arrest were studied. Short time intervals from collapse to initiation of cardiopulmonary resuscitation (CPR) and to provision of definitive care were significantly associated with survival from cardiac arrest. The two times were jointly related, and one short time without the other was unlikely to result in survival. If CPR was initiated within four minutes and if definitive care was provided within eight minutes, 43% of patients survived. If either time was exceeded, the chances of survival fell dramatically. The time to initiation of CPR and definitive care are factors directly influenced by emergency medical service program decisions. A realistic option to improve time to initiation of CPR is widespread citizen CPR training. A possible option to improve the time to definitive care is the training of emergency medical technicians in defibrillation. (<i>JAMA</i>241:1905-1907, 1979)
Effect of Acupuncture for Postprandial Distress Syndrome
Authors: Jing-Wen Yang, Li-Qiong Wang, Xuan Zou, Shi-Yan Yan, Yu Wang, Jing-Jie Zhao, Jian-Feng Tu, Jun Wang, Guang-Xia Shi, Hui Hu, Wei Zhou, Yi Du, Cun-Zhi Liu
Journal: Annals of Internal Medicine (2020)

Background: Postprandial distress syndrome (PDS) is the most common subtype of functional dyspepsia. Acupuncture is commonly used to treat PDS, but its effect is uncertain because of the poor quality of prior studies. Objective: To assess the efficacy of acupuncture versus sham acupuncture in patients with PDS. Design: Multicenter, 2-group, randomized clinical trial. (ISRCTN registry number: ISRCTN12511434) Setting: 5 tertiary hospitals in China. Participants: Chinese patients aged 18 to 65 years meeting Rome IV criteria for PDS. Intervention: 12 sessions of acupuncture or sham acupuncture over 4 weeks. Measurements: The 2 primary outcomes were the response rate based on overall treatment effect and the elimination rate of all 3 cardinal symptoms: postprandial fullness, upper abdominal bloating, and early satiation after 4 weeks of treatment. Participants were followed until week 16. Results: Among the 278 randomly assigned participants, 228 (82%) completed outcome measurements at week 16. The estimated response rate from generalized linear mixed models at week 4 was 83.0% in the acupuncture group versus 51.6% in the sham acupuncture group (difference, 31.4 percentage points [95% CI, 20.3 to 42.5 percentage points]; P < 0.001). The estimated elimination rate of all 3 cardinal symptoms was 27.8% in the acupuncture group versus 17.3% in the sham acupuncture group (difference, 10.5 percentage points [CI, 0.08 to 20.9 percentage points]; P = 0.034). The efficacy of acupuncture was maintained during the 12-week posttreatment follow-up. There were no serious adverse events. Limitation: Lack of objective outcomes and daily measurement, high dropout rate, and inability to blind acupuncturists. Conclusion: Among patients with PDS, acupuncture resulted in increased response rate and elimination rate of all 3 cardinal symptoms compared with sham acupuncture, with sustained efficacy over 12 weeks in patients who received thrice-weekly acupuncture for 4 weeks. Primary Funding Source: Beijing Municipal Science and Technology Commission.
EFFICACY AND SAFETY OF ENDOSCOPIC SLEEVE GASTROPLASTY IN THE TREATMENT OF OVERWEIGHT AND OBESE PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: AM Neto, IB Ribeiro, DTH de Moura, WM Bernardo, S Singh, M Coronel, P Sakai, EGH de Moura
Journal: Endoscopy (2020)

Aims Bariatric surgery is the most effective treatment for obesity and associated comorbidities; however, only 2% of eligible patients undergo surgery. Endoscopic Bariatric and Metabolic Therapies (EBMT) have recently gained popularity due to their minimally invasive nature and higher patient acceptability. Among the EBMTs, Endoscopic Sleeve Gastroplasty (ESG) is a promising procedure, and many recent studies have reported outcomes at short and medium-term follow-up. The aim of this study is to evaluate the efficacy and safety of ESG for the treatment of overweight and obese patients.
Clinical Profile Of Single-Agent Modified-Release Oprozomib Tablets In Patients (Pts) With Hematologic Malignancies: Updated Results From a Multicenter, Open-Label, Dose Escalation Phase 1b/2 Study
Authors: Irene M. Ghobrial, Jonathan L. Kaufman, David S. Siegel, Ravi Vij, Ashraf Badros, Linda Neuman, Hansen Wong, Janet Anderl, Michael Savona
Journal: Blood (2013)
DILUMEN ENDOSCOPICSUBMUCOSAL DISSECTION OF THE ASCENDING COLON IN A RECCURRENT COLONIC LESION
Authors: R Palma, R Maselli, VM Ormando, PA Galtieri, MD Leo, S Carrara, EC Ferrara, G Pellegatta, A Fugazza, A Anderloni, A Repici
Journal: Endoscopy (2020)

The treatment of colonic recurrent lesions could be challanging especially for complex polyps. DiLumen Endolumenal Interventional Platform (EIP) improves endoscopic stability and visualization and it allows an effective tissue traction.
UNDERWATER ENDOSCOPIC RESECTION OF A LST POLYP WITH CIRCUMFERENTIAL INVOLVEMENT OF ILEOCECAL VALVE WITH ILEUM EXTENSION
Authors: D Luna, J Antonio Colan Hernandez, I Marin, EN Caballero, VM De Vega, E Domenech, I Iborra, A Aguilar, M Galindo, H Uchima
Journal: Endoscopy (2020)

Endoscopic findings NBI-near focus and crystal violet chromoendoscopy showing JNET 2A and Kudo III-L. Underwater endoscopic resection was planned. Air aspiration and distilled water instillation until completely filling of the area. EMR with rounded 25mm and 15mm snare (pulse slowcut 70W mode,effect 2)(ESG 300,Olympus).Piecemeal in 2 major fragments and few small fragments, following a systematic and circumferential approach. Complete resection is achieved,with final inspection of scar and terminal ileum without lesions.
THE USE OF BASIC DIETS IN THE TREATMENT OF NEPHRITIS
Authors: W. D. SANSUM
Journal: JAMA (1923)

By the employment of what we are pleased to call a "basic diet," the urinary acidity may be easily reduced to a pH of 7.00 or better. On such diets patients with chronic interstitial nephritis appear to improve, as evidenced by a decrease in blood pressure, albumin and casts in the urine and other symptoms of nephritis and arterial hypertension.
Incidence of Bloodstream Infections, Length of Hospital Stay, and Survival in Patients With Recurrent Clostridioides difficile Infection Treated With Fecal Microbiota Transplantation or Antibiotics
Authors: Gianluca Ianiro, Rita Murri, Giusi Desirè Sciumè, Michele Impagnatiello, Luca Masucci, Alexander C. Ford, Graham R. Law, Herbert Tilg, Maurizio Sanguinetti, Roberto Cauda, Antonio Gasbarrini, Massimo Fantoni, Giovanni Cammarota
Journal: Annals of Internal Medicine (2019)

Fecal microbiota transplantation (FMT) aims to restore the normal composition of gut microbiota and is recommended for treatment of recurrent Clostridioides difficile infection (CDI). Restoration o...
Detection of Aortic Insufficiency by Standard Echocardiography, Pulsed Doppler Echocardiography, and Auscultation
Authors: Paul A. Grayburn, Mikel D. Smith, Rodney Handshoe, Bruce J. Friedman, Anthony N. DeMARIA
Journal: Annals of Internal Medicine (2020)

Abstract To determine the relative sensitivity and specificity of noninvasive methods for detecting aortic insufficiency, we compared the accuracy of auscultation, echocardiography, and pulsed Dopp...
COMPARISON BETWEEN UNDERWATER ENDOSCOPIC MUCOSAL RESECTION AND ENDOSCOPIC SUBMUCOSAL DISSECTION FOR RECURRENT COLORECTAL NEOPLASMS AFTER ENDOSCOPIC REMOVAL: A PROPENSITY SCORE-MATCHED STUDY
Authors: M Ohmori, Y Takeuchi, A Shoji, T Inoue, M Miyake, K Matsueda, K Waki, M Kono, Y Shimamoto, H Fukuda, H Iwagami, H Nakahira, N Matsuura, S Shichijo, A Maekawa, T Kanesaka, K Higashino, N Uedo, R Ishihara, Hiroyuki Okada
Journal: Endoscopy (2020)

Aims Locally recurrent colorectal neoplasms (LRCN) after endoscopic removal (ER) are difficult to treat with conventional ER because of severe fibrosis. Endoscopic submucosal dissection (ESD) and Underwater endoscopic mucosal resection (UEMR) are reportedly effective. We aimed to investigate appropriate indications of these procedures.
Usefulness of Medical Conferences
Authors: Elliott M. Antman, Robert Harrington, Gordon Tomaselli
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
11 YEARS FOLLOW UP (2008 TO 2019 OCTOBER) OF MANAGEMENT OF PATIENTS OF CHRONIC PANCREATITIS WITH DUCTAL DISRUPTION WITH FLUID COLLECTIONS
Authors: P Desai, M Kabrawala, C Patel
Journal: Endoscopy (2020)

Aims A retrospective analysis of our data of management of pancreatic cysts and fistulas in patients of chronic pancreatitis using no contrast technique with guide wire as the only guide.
Interaction between drugs and the gut microbiome
Authors: Rinse K Weersma, Alexandra Zhernakova, Jingyuan Fu
Journal: Gut (2020)

The human gut microbiome is a complex ecosystem that can mediate the interaction of the human host with their environment. The interaction between gut microbes and commonly used non-antibiotic drugs is complex and bidirectional: gut microbiome composition can be influenced by drugs, but, vice versa, the gut microbiome can also influence an individual's response to a drug by enzymatically transforming the drug's structure and altering its bioavailability, bioactivity or toxicity (pharmacomicrobiomics). The gut microbiome can also indirectly impact an individual's response to immunotherapy in cancer treatment. In this review we discuss the bidirectional interactions between microbes and drugs, describe the changes in gut microbiota induced by commonly used non-antibiotic drugs, and their potential clinical consequences and summarise how the microbiome impacts drug effectiveness and its role in immunotherapy. Understanding how the microbiome metabolises drugs and reduces treatment efficacy will unlock the possibility of modulating the gut microbiome to improve treatment.
FGF15 improves outcomes after brain dead donor liver transplantation with steatotic and non-steatotic grafts in rats
Authors: José Gulfo, Floriana Rotondo, Cindy G. Ávalos de León, María Eugenia Cornide-Petronio, Carla Fuster, Jordi Gracia-Sancho, Mónica B. Jiménez-Castro, Carmen Peralta
Journal: Journal of Hepatology (2020)
DIGITAL CHOLANGIOSCOPY FOR DETECTION OF MISSED STONES IN THE BILE DUCTS AFTER ENDOSCOPIC THERAPY- A SINGLE CENTER STUDY
Authors: P Karagyozov, I Boeva, I Tishkov, I Dobreva
Journal: Endoscopy (2020)

Aims To evaluate the efficacy and safety of digital cholangioscopy for detection of missed or retained bile ducts stones after conventional endoscopic therapy.
USEFULNESS OF NEW-DESIGNED HEMOCLIP FOR CASES WITH ENDOSCOPIC PAPILLECTOMY
Authors: M Noda, E Iwasaki, K Minami, A Kayashima, Y Machida, H Tamagawa, Y Takimoto, S Kawasaki, S Fukuhara, T Kanai
Journal: Endoscopy (2020)

Aims Endoscopic papillectomy (EP) is less invasive treatment for duodenal papillary tumor compared with surgical operation such as pancreaticoduodenectomy. However, EP has high risk of complications like hemorrhage, pancreatitis, and perforation. Therefore, intraoperative treatments such as hemostasis and closure of mucosal defect are important for prevention of complication after EP. Although closure by side-viewing endoscope was difficult due to poor maneuverability of clip, new-designed hemoclip was recently developed which could overcome the problem. The present study was aimed to evaluate new-designed hemoclip for EP by comparison with general clip.
Visit-to-Visit Variability of Blood Pressure and Coronary Heart Disease, Stroke, Heart Failure, and Mortality
Authors: Paul Muntner, Jeff Whittle, Amy I. Lynch, Lisandro D. Colantonio, Lara M. Simpson, Paula T. Einhorn, Emily B. Levitan, Paul K. Whelton, William C. Cushman, Gail T. Louis, Barry R. Davis, Suzanne Oparil
Journal: Annals of Internal Medicine (2020)

Variability in blood pressure measurements across outpatient visits is frequently viewed as random fluctuation without clear prognostic importance. This study found that higher visit-to-visit varia...
TO CLIP OR NOT TO CLIP AFTER EMR OF LARGE NONPEDUNCULATED COLORECTAL POLYPS. COST-EFFECTIVENESS ANSWERS BASED ON REAL DATA
Authors: E Albeniz-Arbizu, G Gonzalez-Gete, MA Alvarez, F Estremera-Arevalo, JC Espinos, AZ Gimeno-García, AH de Tejada, J Rodríguez-Sánchez, P Roson, C Guarner, JC Marin, B Ibañez-Beroiz, M Enguita-Germán
Journal: Endoscopy (2020)

Aims Delayed bleeding (DB) is the most common serious complication of EMR. Two randomized clinical trials have recently demonstrated that clip closure of mucosal defects after large nonpedunculated colorectal polyps (LNPCP) reduces the risk of DB. We aimed to analyze the cost-effectiveness of prophylactic clipping depending on the delayed bleeding (DB) risk score described by the Spanish Endoscopy Society Endoscopic Resection Group (GSEED-RE).
Abstract 105: A Prospective, Randomized, Controlled Evaluation of a Contextual In-Hospital BLS Course Versus a Traditional BLS Healthcare Provider Course on Performance in Simulated Cardiac Arrests
Authors: Elizabeth A Hunt, Jordan M Duval-Arnould, Nnenna Chime, Kareen Jones, Merona Hollingsworth, Deborah Aksamit, Ida-Marguerite M Twilley, MaryAnn Luksic, Cheryl Camacho, Daniel P Nogee, Julianna Jung, Kristen Nelson-McMillan, Nicole A Shilkofski, Julianne Perretta
Journal: Circulation (2012)

INTRODUCTION: Most clinical providers are required to maintain BLS certification. However, the AHA Healthcare Provider BLS course is focused on Out-of-Hospital cardiac arrest (OOHCA) techniques, i....
Covid-19: What is the R number?
Authors: Elisabeth Mahase
Journal: BMJ (2020)

It’s been driving policy decisions since covid-19 emerged in late 2019, but what is the R number, and does it matter, asks Elisabeth Mahase

The R number could refer to either the basic reproduction number, known as the R nought or zero (R), or the effective reproduction number (Re).

R describes how many people each infected person will infect on average, assuming that there is no pre-existing immunity in the community. It is often estimated using three factors: the duration of contagiousness after a person becomes infected, the likelihood of infection in each contact between a susceptible person and an infectious person or vector, and the frequency of contact.

Re is the number of people that can be infected by an individual at any specific time, and it changes as the population becomes increasingly immunised, either through individuals gaining …
BioPerine Encapsulated Nanoformulation for Overcoming Drug-Resistant Breast Cancers
Authors: Sindhu C Pillai, Ankita Borah, Amandeep Jindal, Eden Mariam Jacob, Yohei Yamamoto, D. Sakthi Kumar
Journal: Asian Journal of Pharmaceutical Sciences (2020)

The evolving dynamics of drug resistance due to tumor heterogeneity often creates impediments to traditional therapies making it a challenging issue for cancer cure. Breast cancer often faces challenges of current therapeutic interventions owing to its multiple complexities and high drug resistivity， for example against drugs like trastuzumab and tamoxifen. Drug resistance in the majority of breast cancer is often aided by the overtly expressed P-glycoprotein (P-gp) that guides in the rapid drug efflux of chemotherapy drugs. Despite continuous endeavors and ground-breaking achievements in the pursuit of finding better cancer therapeutic avenues, drug resistance is still a menace to hold back. Among newer therapeutic approaches, the application of phytonutrients such as alkaloids to suppress P-gp activity in drug-resistant cancers has found an exciting niche in the arena of alternative cancer therapies. In this work, we would like to present a black pepper alkaloid derivative known as BioPerine-loaded chitosan (CS)-polyethylene glycol (PEG) coated polylactic acid (PLA) hybrid polymeric nanoparticle to improve the bioavailability of BioPerine and its therapeutic efficacy in suppressing P-gp expression in MDA-MB 453 breast cancer cell line. Our findings revealed that the CS-PEG-BioPerine-PLA nanoparticles demonstrated a smooth spherical morphology with an average size of 316 nm, with improved aqueous solubility, and provided sustained BioPerine release. The nanoparticles also enhanced
A COMPARISON OF NKS VS TPS FOR DIFFICULT CANNULATION: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: A Tringali, F Pozzato, E Piovesana, M Rinaldi, A Graziotto, D Adler
Journal: Endoscopy (2020)

Aims The timing of the precutting intervention is important for reducing the complications. The number of transpapillary cannulation attempts and that of pancreatic duct cannulations are two of the most important factors contributing to PEP .The aim of our study was to assess the efficacy and safety of needle knife sphincterotomy (NKS) compared with transpancreatic septotomy (TPS)
ACUTE UPPER GASTROINTESTINAL BLEEDING AT A ‘HOT’ SITE – WHAT FACTORS INFLUENCE ENDOSCOPY?
Authors: R Patel, S Moledina, R Cama, K Besherdas
Journal: Endoscopy (2020)

Aims Acute upper gastrointestinal bleeding (AUGIB) is a medical emergency with a 10% mortality risk. Dividing endoscopy services into two separate sites: elective (‘cold’ site) and emergency (‘hot’ site) is a novel approach that avoids competition for endoscopy slots, thus optimising patient outcomes. We aimed to describe time to endoscopy and outcomes at an exclusively ‘hot site’ and identify predictors of delayed endoscopy (> 24 hours).
INCISION AND SNARING: A SIMPLE TRICK TO GRASP FLAT AND SESSILE COLONICAL LESIONS
Authors: B Mangiavillano, F Auriemma, M Bianchetti, A Repici
Journal: Endoscopy (2020)

Especially in presence of flat lesions the grasping of the lesions can be challenging. Hybrid technique solved this problem, but is also a time-consuming procedure. When sessile or flat lesion can be removed by EMR, a simple trick to grasp the lesion, after submucosal injection, consist into create an incision in the normal mucosa in the fold beyond the proximal edge of the lesion, where will be inserted the tip of the snare. After that the scope is withdrawn slowly, till the complete opening of the snare. Then the lesion can be grasped, deflating the bowel, and cut.
Systemic arterial thrombosis and acute mesenteric ischemia in a patient with COVID-19
Authors: Eya Azouz, Sisi Yang, Laurence Monnier-Cholley, Lionel Arrivé
Journal: Intensive Care Medicine (2020)

This case supports the hypercoagulability state in COVID-19 patients and reinforces the recommendation to apply pharmacological thrombosis prophylaxis.
HEMOSUCCUS PANCREATICUS: A INFREQUENT CAUSE OF LIFE-THREATENING HAEMORRHAGE
Authors: I Tishkov, P Karagyozov, I Boeva, V Gelev, I Zheleva, V Mitova
Journal: Endoscopy (2020)

Aims Hemosuccus pancreaticus (HP) is a rare but life-threatening cause of upper gastrointestinal bleeding through the main pancreatic duct. This condition most commonly follows pseudoaneurysm formation secondary to acute or chronic pancreatitis.
Fecal Microbiota Transplantation for Clostridium difficile Infection
Authors: Dimitri Drekonja, Jon Reich, Selome Gezahegn, Nancy Greer, Aasma Shaukat, Roderick MacDonald, Indy Rutks, Timothy J. Wilt
Journal: Annals of Internal Medicine (2015)

Fecal microbiota transplantation (FMT) is an emerging new therapy for Clostridium difficile infection (CDI). This systematic review assessed the efficacy, comparative effectiveness, and harms of FM...
BILIARY DUCT STENTING AND STENT PATENCY: WHO, HOW LONG, WHY?
Authors: E Dieninytė-Misiūnė, J Valantinas, J Stanaitis
Journal: Endoscopy (2020)

Aims Endoscopic stenting is a foremost therapy in biliary duct strictures with stent occlusion and cholangitis being the most prevalent complications. Since risk factors for stent occlusion are still unknown, we aimed at evaluating effect of stricture etiology on stent patency.
ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension
Authors: Lai-Ming Yung, Peiran Yang, Sachindra Joshi, Zachary M. Augur, Stephanie S. J. Kim, Geoffrey A. Bocobo, Teresa Dinter, Luca Troncone, Po-Sheng Chen, Megan E. McNeil, Mark Southwood, Sergio Poli de Frias, John Knopf, Ivan O. Rosas, Dianne Sako, R. Scott Pearsall, John D. Quisel, Gang Li, Ravindra Kumar, Paul B. Yu
Journal: Science Translational Medicine (2020)

Human genetics, biomarker, and animal studies implicate loss of function in bone morphogenetic protein (BMP) signaling and maladaptive transforming growth factor-β (TGFβ) signaling as drivers of pulmonary arterial hypertension (PAH). Although sharing common receptors and effectors with BMP/TGFβ, the function of activin and growth and differentiation factor (GDF) ligands in PAH are less well defined. Increased expression of GDF8, GDF11, and activin A was detected in lung lesions from humans with PAH and experimental rodent models of pulmonary hypertension (PH). ACTRIIA-Fc, a potent GDF8/11 and activin ligand trap, was used to test the roles of these ligands in animal and cellular models of PH. By blocking GDF8/11- and activin-mediated SMAD2/3 activation in vascular cells, ACTRIIA-Fc attenuated proliferation of pulmonary arterial smooth muscle cells and pulmonary microvascular endothelial cells. In several experimental models of PH, prophylactic administration of ACTRIIA-Fc markedly improved hemodynamics, right ventricular (RV) hypertrophy, RV function, and arteriolar remodeling. When administered after the establishment of hemodynamically severe PH in a vasculoproliferative model, ACTRIIA-Fc was more effective than vasodilator in attenuating PH and arteriolar remodeling. Potent antiremodeling effects of ACTRIIA-Fc were associated with inhibition of SMAD2/3 activation and downstream transcriptional activity, inhibition of proliferation, and enhancement of apoptosis in the vascular wall. ACTRIIA-Fc reveals an unexpectedly prominent role of GDF8, GDF11, and activin as drivers of pulmonary vascular disease and represents a therapeutic strategy for restoring the balance between SMAD1/5/9 and SMAD2/3 signaling in PAH.