AB1152 CORRELATING SERUM RESISTIN LEVEL TO ULTRASONOGRAPHIC FINDINGS OF OSTEOARTHRITIC KNEES AFTER INTRA-ARTICULAR GLUCOCORTICOID INJECTION
Authors: Sameh Al-Zayyat, Hany Eitta, abdelrahman labib
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> Osteoarthritis (OA) is one of the ten disabling diseases affecting 9.6% of men and 18% of women aged over 60 worldwide (1). OA characterized by articular cartilage loss, subchondral bone remodeling, soft tissue damage and low grade synovitis It is the most common form of arthritis and major cause of disability in the adult population (2). The main source of resistin in humans is mononuclear cells(3). Evidence has shown that higher serum levels of resistin in patients with severe OA compared to controls with no OA and resistin are detected in both serum and synovial fluid, proving its systematical and local involvement in inflammatory changes of OA (4). <h3>Objectives</h3> The aim of this work is to study the effect of local GC intra articular injection on the level of serum resistin in OA knees and to study the relation between different serum levels of resistin and US findings of the knee. <h3>Methods</h3> Thirty patients with primary knee OA Grade 2-3 Kellgren Lawrence score (5) in acute flare according to ACR criteria with or without effusion will be recruited for the study from the Physical medicine, Rheumatology and Rehabilitation Outpatient Clinic of Al-Azhar University Hospitals starting from November 2017 till may 2018. Patients with secondary OA. All systemic autoimmune diseases. Previous local GC injection within 3 months preoperative evaluation were excluded. Twenty healthy individuals matched for age, sex and BMI with patients were also enrolled in this study as a control group. Serum Resistin level was measured and Musculoskeletal ultrasound examination of the knee before and three months after steroid injection was done by TOSHIBA APILO 400. linear probe frequency 12L5. Effusion and Synovitis were assessed. <h3>Results</h3> Serum resistin showed significant difference (p-value &lt; 0.05) before and after injection. It was 7.6 ng/ml in patients before injection and 5.1 ng/ml in patients after injection. US showed significant difference (p-value &lt; 0.001) before and after injection as regard effusion level. <h3>Conclusion</h3> Resistin could be considered as an important severity marker of knee OA. Serum resistin level is markedly decreased after intra articular steroid injection into OA knee joint The longer the duration of illness the higher the resistin level. The older the age the higher the resistin level. The longer the duration of illness, the higher the radiological grade.. <h3>References</h3> [1] Hardcastle SA, Gregson CL, Deere KC, Smith GD (2013): High bone mass is associated with an increased prevalence of joint replacement: a case –control study. Rheumatology, 52 (6): 1042-51. [2] Karvonen-Gutierrez CA, Harlow SD, Mancuso P, Jacobson J (2013): Association of leptin levels with radiographic knee osteoarthritis among a cohort of midlife women, Arthritis Care and Research, 65 (6): 936-44. [3] Lazar MA (2007): Resistin and Obesity associated metabolic diseases. Horm Metab Res., 39:710-6. [4] Perruccio V, Mahomed N, Chandran V, Gandhi R (2014): Plasma adipokine levels and their association with overall burden of painful joints among individuals with hip and knee osteoarthritis. Journal of Rheumatology, 41(2): 334–337. [5] Kellgren J and Lawrence J (1957): Radiological assessment of osteoarthritis. Ann Rheum Dis.,16 (4):494-502. <h3>Acknowledgement</h3> Prof. Dr. Hassan Bassiouni Dr. Abdullah M Gaafar <h3>Disclosure of Interests</h3> None declared