tbuckley/cabot-search huggingface dataset:
Electronic Cigarette Use Among Populations of Women During Reproductive Years—Reply
Authors: Buyun Liu, Wei Bao
Journal: JAMA Pediatrics (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
P2.14-63 Cost Analysis of the Management of CNS Metastases in Patients with Advanced ALK+ NSCLC: Alectinib vs Crizotinib
Authors: B. Massuti, M. Lazaro, D. Isla, R. Gordo, L. Ruiz De Alda, N. Ortega, I. Oyagüez
Journal: Journal of Thoracic Oncology (2019)
Particulate matter of 2.5 μm or less in diameter disturbs the balance of TH17/regulatory T cells by targeting glutamate oxaloacetate transaminase 1 and hypoxia-inducible factor 1α in an asthma model
Authors: Licheng Sun, Jinrong Fu, Sheng-Hao Lin, Jin-Lyu Sun, Li Xia, Ching-Hsiung Lin, Lijuan Liu, Caiyan Zhang, Lan Yang, Ping Xue, Xiang Wang, Saihua Huang, Xiao Han, Hua-Ling Chen, Ming-Shyan Huang, Xiaobo Zhang, Shau-Ku Huang, Yufeng Zhou
Journal: Journal of Allergy and Clinical Immunology (2019)
Doxil (D), Vincristine (V), Reduced Frequency Dexamethasone (d) and Revlimid(R) (DVd-R) Results in a High Response Rate in Patients with Refractory Multiple Myeloma (RMM).
Authors: Rachid Baz, Toni K. Choueiri, Rony Abou Jawde, Bridget McGowan, Yvette Ellis, Catherine Brand, Mohamad A. Hussein
Journal: Blood (2005)
Cognitive Study of Reactivity to IPH1101 of Peripheral γδ T Lymphocytes from Chronic Myeloid Leukemia, Multiple Myeloma and Follicular Lymphoma Patients.
Authors: Helene Sicard, Jean-Francois Rossi, Philippe Rousselot, Alexis Collette, Christine Paiva, Sophie Ingoure, Sylvie Lafaye de Micheaux
Journal: Blood (2008)
P1.03-13 Genomic Landscape of Brazilian Non-Small Cell Lung Cancer
Authors: L. Leal, P. De Marchi, L. Sussuchi Da Silva, F. Ferreira Da Silva, L. Campanha Novaes, Y. Camargo Rodrigues, W. Dos Santos, E. Albino Da Silva, A. Evangelista, R. Reis
Journal: Journal of Thoracic Oncology (2019)
Abstract 371: The Role of Survivin in Cardiac Regeneration
Authors: Tien-Jui Tsang
Journal: Circulation Research (2016)

Heart failure continues to be the major cause of mortality in many countries. How to reduce the loss of cardiac function after injury continues to be a major challenge in cardioprotective treatment. Survivin (SVV) is the smallest member in IAP (Inhibitor of apoptosis) family and has multiple functions such as inhibiting cell apoptosis and enhancing cell proliferation. SVV expresses in nucleus of proliferating cardiomyocyte during heart development but disappear in adult stage. However after injury, SVV is induced in the cytoplasm of cardiomyocyte in peri-infarct region. We established inducible conditional SVV knockout transgenic mouse to investigate the importance of SVV after myocardial infarction. Cardiac-specific SVV knockout mice exhibit poor cardiac function and more apoptotic cardiomyocytes compared to wild-type mice after injury. In order to confirm localization is related to the function of SVV, we have established adenovirus carrying SVV or SVV fused with NLS (nuclear-localization signal). SVV locates in cytoplasm after virus infection but NLS-SVV could be detected in both cytoplasm and nucleus. Both SVV and NLS-SVV inhibited cell apoptosis in vitro but only NLS-SVV enhanced neonatal mouse cardiomyocyte proliferation. Mice received intramyocardial injection of virus shows better ejection fraction after myocardial infarction and less apoptotic cardiomyocytes in peri-infarct region, and more H3P-positive cardiomyocytes are observed in border zone overexpressing NLS-SVV group. We believe this dual functional SVV can be applied in future cardioprotective therapy.
Infographic. Developing home-based cardiac rehabilitation for people post-transient ischaemic attack (TIA) and ischaemic stroke
Authors: Neil Heron, Frank Kee, Jonathan Mant, Margaret E Cupples, Michael Donnelly
Journal: British Journal of Sports Medicine (2019)

The value of cardiac rehabilitation (CR) after a transient ischaemic attack (TIA) or ‘minor’ stroke is untested despite these conditions sharing similar pathology and risk factors to coronary heart disease.1 Following a TIA and/or minor stroke, patients are at significant risk of further vascular events, particularly within the acute period.2

We therefore wanted to develop and test the feasibility of conducting a randomised controlled trial of a novel home-based rehabilitation programme,3 4 The Healthy Brain Rehabilitation Manual , with a pedometer and telephone follow-up from a health professional, for patients with a first TIA or minor stroke of atherosclerotic origin, using the core components of home-based …
Space for Calaspargase? A New Asparaginase for Acute Lymphoblastic Leukemia
Authors: Glen Lew
Journal: Clinical Cancer Research (2019)

In December 2018, the FDA approved calaspargase pegol-mknl (Asperlas, Servier Pharmaceuticals) for acute lymphoblastic leukemia (ALL) in children and young adults up to age 21. Asparaginase is a critical component in the treatment of ALL, but the niche for calaspargase within current treatment protocols is unclear.See related article by Li et al., p. 328.
EP1.01-90 The Prognostic Role of Mean Platelet Volume in Patients with Advanced Non-Small Cell Lung Cancer
Authors: K. Cholidou, N. Anagnostopoulos, D. Grapsa, E. Kokkotou, R. Trigidou, A. Vassias, S. Tsagouli, P. Bakakos, I. Kotteas, I. Gkiozos
Journal: Journal of Thoracic Oncology (2019)
P1.01-02 Pemetrexed-Carboplatin Versus Paclitaxel (Weekly)-Carboplatin as First Line Chemotherapy in Advanced Non-Squamous NSCLC
Authors: P. Malik, A. Yadav, D. Jain, S. Pathy, A. Mohan, S. Khurana, S. Kumar
Journal: Journal of Thoracic Oncology (2019)
P1.03-14 HLA-E and FAT1 in Head and Neck and Lung Cancer. The Effect of Osimertinib or Olmutinib with Artesunate (Dihydroartemisinin)
Authors: I. Chaib, R. Rosell, P. Cao, N. Karachaliou, X. Cai, M. Hermsen, D. Llige Santafe, M. Santarpia, M. Gonzalez-Cao, F. Cecere, M. Filipska, C. Pedraz, J. Bracht, M. Ito, A. Aguilar Hernandez, J. Codony-Servat, A.F. Cardona
Journal: Journal of Thoracic Oncology (2019)
MA25.09 Navigating Anlotinib Precision Therapy Through the Genetic Profiling of Circulating DNA in Non-Small Cell Lung Cancer Patients
Authors: J. Lu, H. Zhong, J. Wu, T. Chu, L. Zhang, H. Li, Q. Wang, R. Li, Y. Zhao, A. Gu, C. Shi, L. Xiong, X. Zhang, W. Zhang, Y. Lou, B. Yan, Y. Dong, Y. Zhang, B. Li, L. Zhang, X. Zhao, K. Li, B. Han
Journal: Journal of Thoracic Oncology (2019)
Reply:
Authors: Sumeet K. Asrani
Journal: Hepatology (2019)

Potential conflict of interest: Nothing to report. We appreciate the interest in our work. Drs. Carvao and Jasmins highlight several important points. First, serum creatinine, sodium, and estimated glomerular filtration rate (eGFR) are all imperfect surrogates of renal function in patients with cirrhosis. This is especially true in patients with decompensated liver disease, whereby the influence of extrahepatic factors may impede accurate estimation. Often, renal function is dependent on where the patient lies on the acute kidney injury/chronic kidney disease continuum, the degree of liver dysfunction, and other relevant patient characteristics. Developing an estimating equation for each and every subset of cirrhosis is untenable. One also assumes steady state in predictive models, but manipulation or alterations are possible across the breadth of current glomerular filtration rate (GFR) estimating equations. This includes changes in relevant parameters with diuresis (serum creatinine, serum sodium), changes with use of anticoagulation or nutrition (prothrombin time), changes with volume management (albumin, degree of ascites), changes with muscle mass (gender), or assessment of whether serum creatinine is reflective of acute kidney injury or chronic kidney disease or a combination thereof. Notwithstanding these factors, there is a need to include objective measures in predictive models. In our study, the use of glomerular filtration rate assessment in liver disease (GRAIL) to identify low GFR may be helpful for clinically relevant decisions before and after transplantation.1 Although a direct comparison was not carried out with the royal free hospital equation, the addition of ascites or serum sodium did not improve performance characteristics. The addition of ascites had marginal improvement in bias (eGFr–GFR 6.7 mL/min/1.73 m2 with ascites versus 7.1 mL/min/1.73 m2), but the differences were not clinically significant and the need to have an objective set allowed us to further remove it from model building. In a subsequent study, replacing serum creatinine with GRAIL (as compared with other estimates of GFR) in the Model for End‐Stage Liver Disease ascites–sodium score improved the prediction of wait‐list mortality, especially for women and those with the highest disease severity.2 Second, measured GFR remains important. There is a need to identify specific scenarios whereby estimating equations may not be enough: The clinician may be forced to instead obtain measured GFR, however onerous or expensive.3 Finally, accurate estimation of renal function in the future may rely on combining factors that capture separate surrogates of renal structure and function, as well as take the clinical context into consideration. Given the pervasive and dynamic effect of renal dysfunction in patients with liver disease, and coupled with the increasing burden of cirrhosis worldwide, continued refinement of current models is warranted.
Machine Learning for Suicide Research–Can It Improve Risk Factor Identification?
Authors: Seena Fazel, Lauren O’Reilly
Journal: JAMA Psychiatry (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Assessment of Liver Damage with Transient Hepatic Elastography (FIBROSCAN) in patients with chronic Graft-Versus-Host Disease
Authors: Cristina Skert, Katia Prestini, Annalisa Peli, Luciano Biasi, Carla Filí, Michele Malagola, Cesare Bergonzi, Monia Mendeni, Aldo M. Roccaro, Massimo Puoti, Domenico Russo
Journal: Blood (2008)
MA16.05 Wearable Technology for Preconditioning Before Thoracic Surgery: A Feasibility Study
Authors: Y. Patel, D. Hylton, M. Rok, M. Beauchamp, J. Wald, L. Mbuagbaw, C. Finley, J. Agzarian, Y. Shargall, C. Fahim, W. Hanna
Journal: Journal of Thoracic Oncology (2019)
Calreticulin Mutation Is Associated with Milder Disease in Patients with Post Essential Thrombocythemia Myelofibrosis (PET-MF) Compared with JAK2V617F Mutation: A Study from the AGIMM Group
Authors: Paola Guglielmelli, Giada Rotunno, Giada Brogi, Annalisa Pacilli, Costanza Bogani, Carmela Mannarelli, Alessandro Pancrazzi, Rajmonda Fjerza, Lisa Pieri, Elisa Rumi, Daniela Pietra, Federica Delaini, Silvia Salmoiraghi, Aldesia Provenzano, Laura Giunti, Sabrina Giglio, Margherita Maffioli, Alberto Bosi, Alessandro Rambaldi, Tiziano Barbui, Francesco Passamonti, Mario Cazzola, Alessandro Maria Vannucchi
Journal: Blood (2014)
Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia
Authors: Mart Toots, Jeong-Joong Yoon, Robert M. Cox, Michael Hart, Zachary M. Sticher, Negar Makhsous, Roland Plesker, Alec H. Barrena, Prabhakar G. Reddy, Deborah G. Mitchell, Ryan C. Shean, Gregory R. Bluemling, Alexander A. Kolykhalov, Alexander L. Greninger, Michael G. Natchus, George R. Painter, Richard K. Plemper
Journal: Science Translational Medicine (2019)

A next-generation, broad-spectrum, orally efficacious influenza A and B virus inhibitor is associated with a high genetic resistance barrier.
Abstract 15433: Pattern of Troponin Elevation in Acute Hyperglycemic Complications
Authors: Ahmad Awan, Richard Ogunti, Priscilla Wessly, Hamid Yaqoob, BInu Kc, Basharat Ahmad, Mohammad Munawwar, Vishal Poddar
Journal: Circulation (2018)

Background: DKA and HHS are the most common acute complications of diabetes mellitus. Few researches have documented elevation of cardiac troponin without acute coronary syndrome in diabetic emerge...
P2.04-55 Tumor Spread Through Air Spaces Is Associated with the Non-Inflamed Immune Microenvironment in Lung Squamous Cell Carcinoma
Authors: T. Karasaki, Y. Kobayashi, A. Shinozaki-Ushiku, C. Konoeda, K. Kitano, K. Nagayama, M. Sato, A. Hosoi, K. Kakimi, J. Nakajima
Journal: Journal of Thoracic Oncology (2019)
MA20.02 GAD1 Expression and Its Methylation Become Indicators of Malignant Behavior in Thymic Epithelial Tumor
Authors: S. Soejima, K. Kondo, M. Tsuboi, R. Kishibuchi, K. Muguruma, B. Tegshee, K. Kajiura, Y. Kawakami, N. Kawakita, M. Yoshida, H. Takizawa, A. Tangoku, N. Wusiman
Journal: Journal of Thoracic Oncology (2019)
MA11.11 STK11/LKB1 Genomic Alterations Are Associated with Inferior Clinical Outcomes with Chemo-Immunotherapy in Non-Squamous NSCLC
Authors: F. Skoulidis, K. Arbour, M. Hellmann, P. Patil, M. Marmarelis, D. Owen, M. Awad, J. Murray, B. Levy, J. Hellyer, J. Gainor, T. Stewart, S. Goldberg, A. Dimou, C. Bestvina, A. Cummings, Y. Elamin, V. Lam, J. Zhang, C. Shu, J. Riess, C. Blakely, C. Pecot, L. Mezquita, F. Tabbò, A. Sacher, M. Scheffler, B. Ricciuti, D. Venkatraman, H. Rizvi, C. Liu, R. Johnston, Y. Ni, J. Azok, M. Kier, S. Katz, K. Davies, J. Segal, L. Ritterhouse, H. Shaish, L. Lacroix, R. Memmott, J. Madrigal, J. Goldman, S. Lau, J. Killam, Z. Walther, B. Carter, M. Woodcock, J. Roth, S. Swisher, N. Leighl, S. Digumarthy, M. Mooradian, J. Rotow, J. Wolf, G. Scagliotti, D. Planchard, B. Besse, T. Bivona, D. Gandara, E. Garon, N. Rizvi, D.R. Camidge, K. Schalper, R. Herbst, A. Shaw, J. Neal, H. Wakelee, J. Brahmer, P. Jänne, D. Carbone, C. Aggarwal, N. Pennell, C. Rudin, V. Papadimitrakopoulou, J. Heymach
Journal: Journal of Thoracic Oncology (2019)
P1.18-26 Pretreatment Risk Factors for Postoperative Pulmonary Complication After Neoadjuvant Concurrent Chemoradiotherapy for NSCLC
Authors: W.S. Yu, J.W. Suh, C.Y. Lee, J.G. Lee, D.J. Kim, H.C. Paik, K.Y. Chung, S.Y. Park
Journal: Journal of Thoracic Oncology (2019)
Defective bicarbonate reabsorption in Kir4.2 potassium channel deficient mice impairs acid-base balance and ammonia excretion
Authors: Yohan Bignon, Laurent Pinelli, Nadia Frachon, Olivier Lahuna, Lucile Figueres, Pascal Houillier, Stéphane Lourdel, Jacques Teulon, Marc Paulais
Journal: Kidney International (2019)
P1.01-18 Integrated Genomic and DNA Methylation Analyses of Non-Small Cell Lung Cancer Patients with Brain Metastases
Authors: Y. Fan, Y. Xu, Z. Huang, K. Chen, H. Han-Zhang, J. Ye, H. Lu, J. Qin, F. Xie, N. Han, L. Gong, X. Xu
Journal: Journal of Thoracic Oncology (2019)
P1.09-22 Programmed Death Ligand-1 Expression in Non-Small Cell Lung Cancer in Mexican Population and Correlation with Clinicopathologic Features
Authors: L. Bornstein, O. Macedo-Perez, I. Lyra Gonzalez, C. Bautista-Wong, J. Cienfuegos-Meza, K. Campos-Peralta, E. Jimenez-Fuentes
Journal: Journal of Thoracic Oncology (2019)
Complications after Radiofrequency Ablation for Hepatocellular Carcinoma: A Multicenter Study Involving 9,411 Japanese Patients
Authors: Masaki Maeda, Issei Saeki, Isao Sakaida, Hiroshi Aikata, Yasuyuki Araki, Chikara Ogawa, Kazuya Kariyama, Kazuhiro Nouso, Mikiya Kitamoto, Haruhiko Kobashi, Shuichi Sato, Hiroshi Shibata, Kouji Joko, Shintaro Takaki, Hiroyuki Takabatake, Akemi Tsutsui, Koichi Takaguchi, Tetsu Tomonari, Shinichiro Nakamura, Takakazu Nagahara, Atsushi Hiraoka, Tomomitsu Matono, Masahiko Koda, Mari Mandai, Tomohiko Mannami, Akeri Mitsuda, Takashi Moriya, Kazuhisa Yabushita, Joji Tani, Takahito Yagi, Takahiro Yamasaki
Journal: Liver Cancer (2019)

&lt;b&gt;&lt;i&gt;Introduction:&lt;/i&gt;&lt;/b&gt; Radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) is considered a safe and minimally invasive procedure. We previously reported that the mortality and complication rates for RFA were 0.038% (5/13,283 patients) and 3.54% (579 complications/16,346 procedures), respectively, from 1999 to 2010 (previous period). In this study, we investigated the clinical criteria for RFA and the mortality and complication rates from 2011 to 2015 (recent period). &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; Data were collected from 25 centers by using a questionnaire developed by the Chugoku-Shikoku Society for Local Ablation Therapy of HCC. The criteria for RFA, RFA modification, use of image-guidance modalities, mortality, and complications during the previous and recent periods were compared. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; We evaluated 11,298 procedures for 9,411 patients, including those that involved new devices (bipolar RFA and internally adjustable electrode system). The criterion of hepatic function for RFA increased from a Child-Pugh score ≤8 during the previous period to ≤9 during the recent period. The criteria regarding the tumor location and other risk factors have been expanded recently because of the increased use of several modifications of the RFA procedure and image-guidance modalities. The mortality rate was 0.064% (6/9,411 patients), and the complication rate was 2.92% (330 complications/11,298 procedures). There was no difference in mortality rates between the 2 periods (&lt;i&gt;p&lt;/i&gt; = 0.38), but the complication rates was significantly lower during the recent period (&lt;i&gt;p&lt;/i&gt; = 0.038). &lt;b&gt;&lt;i&gt;Discussion and Conclusions:&lt;/i&gt;&lt;/b&gt; Our findings confirmed that RFA, including the use of new devices, is a low-risk procedure for HCC, despite the expansion of the criteria for RFA during the recent period.
P1.14-38 Identification of FGFR1-3 Fusions in Lung Cancers Using Comprehensive Next-Generation Sequencing
Authors: G. Lin, M. Yuan, P. Tian, L. Chen, C. Shi, Y. Wu, F. Yu, L. Zhu, R. Chen, X. Xia
Journal: Journal of Thoracic Oncology (2019)
P2.05-18 Tissue Sampling and Prognostic Biomarkers Analysis of Peripheral Lung Tumors Using R-EBUS. Single Centre Retrospective Study
Authors: S. Badovinac, M. Roglić, M. Korsic, L. Bitar, M. Jakopovic, S. Smojver-Ježek, M. Samarzija
Journal: Journal of Thoracic Oncology (2019)
P2.17-12 Robotic Assisted Segmentectomy - Intravenous vs Intrabronchial Fluorescence Thoracoscopy to Identify the Intersegmental Plane
Authors: S.M. Kolokotroni, A. Dhanji, H. Wilson, S. Stamenkovic, D. Waller
Journal: Journal of Thoracic Oncology (2019)
P1.06-03 Selective Depletion of Foxp3+ Regulatory T Cells After Local Radiotherapy Induces Abscopal Effects in Murine Malignant Mesothelioma
Authors: M. Kohno, J. Murakami, L. Wu, M. Chan, Z. Yun, M. De Perrot
Journal: Journal of Thoracic Oncology (2019)
P2.17-16 Genomic Heterogeneity and Evolutionary Trajectory in Multifocal Synchronous Lung Cancer
Authors: S. Liu, C. Zhang, J. Su, X. Gao, L. Chang, H. Yan, Y. Guan, H. Tu, J. Yang, X. Zhang, X. Yang, Y. Wu, W. Zhong
Journal: Journal of Thoracic Oncology (2019)
The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation
Authors: Andrea Hildebrandt, Mirko Brüggemann, Cornelia Rücklé, Susan Boerner, Jan B. Heidelberger, Anke Busch, Heike Hänel, Andrea Voigt, Martin M. Möckel, Stefanie Ebersberger, Anica Scholz, Annabelle Dold, Tobias Schmid, Ingo Ebersberger, Jean-Yves Roignant, Kathi Zarnack, Julian König, Petra Beli
Journal: Genome biology (2019)

Abstract Background Cells have evolved quality control mechanisms to ensure protein homeostasis by detecting and degrading aberrant mRNAs and proteins. A common source of aberrant mRNAs is premature polyadenylation, which can result in non-functional protein products. Translating ribosomes that encounter poly(A) sequences are terminally stalled, followed by ribosome recycling and decay of the truncated nascent polypeptide via ribosome-associated quality control. Results Here, we demonstrate that the conserved RNA-binding E3 ubiquitin ligase Makorin Ring Finger Protein 1 (MKRN1) promotes ribosome stalling at poly(A) sequences during ribosome-associated quality control. We show that MKRN1 directly binds to the cytoplasmic poly(A)-binding protein (PABPC1) and associates with polysomes. MKRN1 is positioned upstream of poly(A) tails in mRNAs in a PABPC1-dependent manner. Ubiquitin remnant profiling and in vitro ubiquitylation assays uncover PABPC1 and ribosomal protein RPS10 as direct ubiquitylation substrates of MKRN1. Conclusions We propose that MKRN1 mediates the recognition of poly(A) tails to prevent the production of erroneous proteins from prematurely polyadenylated transcripts, thereby maintaining proteome integrity.
MA06.01 Mediastinal Lymph Node Dissection (MLND) v Systematic Sampling (SS) v Neither (NN) in Population-Based Cohort
Authors: M. Ray, N. Faris, C. Fehnel, C. Houston-Harris, O. Akinbobola, P. Ojeabulu, M. Smeltzer, R. Osarogiagbon
Journal: Journal of Thoracic Oncology (2019)
P2.14-32 Epigenetic Silencing of SPARC in NSCLCs
Authors: F. Fabrizio, A. Sparaneo, A. Rossi, A. Pantalone, A. Fontana, F. Centra, F. Fiordelisi, N. Orlando, P. Graziano, D. Trombetta, V. Fazio, L. Muscarella
Journal: Journal of Thoracic Oncology (2019)
EP1.03-01 Molecular Spectrum of Patients with JAK1 Mutations in East Asian Non-Small Cell Lung Cancer
Authors: X. Yu, C. Xu, W. Wang, Q. Zhang, W. Zhuang, Y. Zhu, Y. Huang, G. Chen, M. Fang, T. Lv, Y. Song
Journal: Journal of Thoracic Oncology (2019)
P1.18-16 Is Tumor Shrinking During Chemoradiation for LA-NSCLC a Biomarker for Outcome?
Authors: S. Ramella, S. Silipigni, M. Fiore, C. Greco, E. Ippolito, P. Zuccoli, B. Santo, R. D'Angelillo
Journal: Journal of Thoracic Oncology (2019)