tbuckley/cabot-search huggingface dataset:
用于 RDEB 的 PTCy BMT
Authors: C.L. Ebens, J.A. McGrath, K. Tamai, A. Hovnanian, J.E. Wagner, M.J. Riddle, D.R. Keene, T.E. DeFor, R. Tryon, M. Chen, D.T. Woodley, K. Hook, J. Tolar
Journal: British Journal of Dermatology (2019)

泛发型重度隐性营养不良性大疱性表皮松解症 (RDEB‐GS) 是一种罕见的不可治愈的遗传疾病,此疾病患者皮肤的主要成分 7 型胶原 (C7) 出现缺陷或缺失。 由此导致皮肤和粘膜与身体脱离,引发水疱和伤口。骨髓移植 (BMT) 可恢复皮肤中的 C7,其机理很可能是提供可转变为健康新皮肤细胞的间充质干细胞 (MSC)。但是,BMT 是一种存在风险的不适操作,因为需要用药来阻止患者免疫系统排斥捐献的骨髓,而这些药物本身可能导致疾病,有时甚至致死。移植组织中的免疫细胞甚至可能攻击患者,导致移植物抗宿主疾病 (GvHD)。 这些明尼苏达州立大学的医生们在 10 名 RDEB‐GS 儿童中尝试了一种不同的 BMT 方案,该方案使用较低强度的移植前免疫抑制。移植后 3 天,向他们给用称为环磷酰胺 (PTCy) 的免疫抑制药物。2 个月后,当患者身体已经接受供体组织时,他们可以从相同供体接受更多 MSC。 此移植在 3 名患者中失败,其中 2 名经历了重复的 BMT,1 名发生了严重并发症,并在 1 年后死亡。移植成功患者在皮肤活检中显示了 C7 增多和症状改善以及瘙痒、疼痛和水疱皮肤面积减少的趋势。短期无人发生 GvHD。 作者们得出结论,PTCy BMT 在 RDEB‐GS 患者中是可行的,甚至使用“不很完美匹配”的供体时也是如此,且允许通过相同供体重复“额外”MSC 移植。
<i>In vivo</i> photoacoustic imaging dynamically monitors the structural and functional changes of ischemic stroke at a very early stage
Authors: Jing Lv, Shi Li, Jinde Zhang, Fei Duan, Zhiyou Wu, Ronghe Chen, Maomao Chen, Shanshan Huang, Haosong Ma, Liming Nie
Journal: Theranostics (2019)

Ischemic stroke (IS) is one of the leading causes of death and accounts for 85% of stroke cases.Since the symptoms are not obvious, diagnosis of IS, particularly at an early stage, is a great challenge.Photoacoustic imaging combines high sensitivity of optical imaging and fine resolution of ultrasonography to non-invasively provide structural and functional information of IS.Methods: We adopted three rapid photoacoustic imaging systems with varying characteristics, including a portable handheld photoacoustic system, high-sensitivity bowl-shaped array photoacoustic computed tomography (PACT), and high-resolution photoacoustic microscopy (PAM) to assess the stereoscopic and comprehensive pathophysiological status of IS at an early stage.Two representative models of IS, referring to photothrombosis and middle cerebral artery occlusion (MCAO) models, were established to verify the feasibility of photoacoustic imaging detection.Results: Non-invasive, rapid PACT of the IS model in mouse provided structural information of the brain lesion, achieving early disease identification (5 min after the onset of disease).Moreover, it was able to dynamically reflect disease progression.Quantitative high-resolution PAM allowed observation of pathological changes in the microvascular system of mouse brain.In terms of functional imaging, significant differences in oxygen saturation (sO 2 ) levels between infarcted and normal areas could be observed by PACT, permitting effective functional parameters for the diagnosis of IS.Conclusions: We used PACT to perform full-view structural imaging and functional imaging of sO 2 in IS at the macroscopic level, and then observed the microvascular changes in the infarcted area at the microscopic level by using PAM.This work may provide new tools for the early diagnosis of IS and its subsequent complications as well as assessment of disease progression.
The changes in ECG ST segment and mechanical function of regional ischemic myocardium during afterload reduction in isolated dog hearts with coronary stenosis.
Authors: Jun Watanabe, Yukio Maruyama, Kouichi Ashikawa, Shogen Isoyama, Shoichi Satoh, Hideyuki Suzuki, Yoshio Shimizu, Eiji Ino-Oka, Tamotsu Takishima
Journal: Circulation (1986)

By measuring ECG ST segment deviation and regional mechanical dysfunction, we assessed the effects of an alteration in afterload pressure on regional myocardial ischemia due to a partial coronary occlusion of the left circumflex coronary artery (CFX). Eight isolated, perfused and paced dog hearts were loaded with an artificial arterial system which simulated the aortic input impedance of the dog arterial tree. Afterload pressure was altered by stepwise changes in peripheral resistance (Rp), while left ventricular end-diastolic pressure (LVEDP) and heart rate were kept constant. Coronary perfusion pressure (CPP) was kept equal to mean aortic pressure (AoP). ECG and myocardial systolic segment shortening (SS) were measured in both areas perfused by the CFX and the left anterior descending coronary artery (LAD). In the presence of CFX stenosis, mean AoP decreased from 96 +/- 7 to 46 +/- 7 mmHg following a decrease in Rp and cardiac output increased progressively from 465 +/- 30 to 1055 +/- 100 ml/min. In this situation, CFX coronary blood flow decreased from 75 +/- 2 to 28 +/- 6 ml/100 g/min. Epicardial ECG in the ischemic region showed two types of ST segment deviation after CFX stenosis: ST segment elevation and ST segment depression. Moreover, following afterload reduction, these individual ECG ST segment changes showed further deviations. The levels of mean AoP, below which further ST segment deviations significantly occurred, were as follows: 71 +/- 6 mmHg in ST segment elevation cases and 52 +/- 7 mmHg in ST segment depression cases. Myocardial systolic segment shortening in the ischemic region also significantly decreased following CFX stenosis (91 +/- 8% of pre-ischemic control, p less than 0.05). Then, during afterload reduction, SS in the CFX area appeared to be bimodal and it definitely decreased when mean AoP was 46 +/- 7 mmHg. To enhance the sensitivity of detection of further mechanical dysfunction throughout afterload reduction following regional myocardial ischemia, we calculated percentage values of the SS in the CFX area to the SS in the LAD area at each Rp. By this normalization, mechanical dysfunction was found when mean AoP was below 67 +/- 5 mmHg. These results suggest that reduction in afterload pressure below a certain level aggravated the regional ischemia, despite an increase in cardiac output, and to detect this change in the ischemic region during afterload reduction, ECG ST segment deviation seems to be a useful indicator.(ABSTRACT TRUNCATED AT 400 WORDS)
Phase I Study of Clofarabine with Standard-Dose Infusional Cytarabine (Ara-C) as Intensive Induction Therapy for Newly-Diagnosed De Novo Acute Myeloid Leukemia in Older Adults Age ≥60 Years.
Authors: James Foran, Angelina The, Pam Dixon, Marcel Devetten, Mikkael Sekeres
Journal: Blood (2007)
The Quantitative Assessment of WT1 Allows To Distinguish between Primary and Secondary or Reactive Hypereosinophilia.
Authors: Daniela Cilloni, Francesca Messa, Giovanni Martinelli, Enrico Gottardi, Ilaria Defilippi, Francesca Arruga, Sonia Carturan, Emanuela Messa, Emilia Giugliano, Valentina Rosso, Serena Merante, Annalisa Charenza, Michela Rondoni, Emanuela Ottaviani, Mario Tiribelli, Fabrizio Pane, Michele Baccarani, Giuseppe Saglio
Journal: Blood (2005)
Generation of Anti-Leukemia Reactive T-Cells by Costimulation with Established B-ALL Cell Lines Expressing Costimulatory Molecules.
Authors: Ying Yan, Peter Steiherz, Jianda Ruan, Yibang Chen, Sunil Abhyankar, Xiuqin Guan, Casey Williams, Robert Belt, Joseph McGuirk
Journal: Blood (2004)
Thrombocytopenia and Cardiomyopathy (trac): A New Single Gene Mutation Resulting in Severe Platelet and Heart Abnormalities in Mice.
Authors: Leonard D. Shultz, Bonnie L. Lyons, Roderick T. Bronson, Leah Rae Donahue, Lisa M. Burzenski, Bruce Gott, Belinda S. Harris, Joseph E. Italiano, Kenneth R. Johnson
Journal: Blood (2005)
Abnormalities of cardiac sympathetic innervation in arrhythmogenic right ventricular cardiomyopathy: quantitative assessment of presynaptic beta-adrenergic receptor density with positron emission tomography
Authors: T. Wichter, M. Schäfers, C.G. Rhodes, M. Borggrefe, H. Lerch, A.A. Lammertsma, O. Schober, G. Breithardt, P.G. Camici
Journal: Circulation (2000)
Dapsone as Second-Line Drug in Non-Splenectomized Patients with Chronic Idiopathic Thrombocytopenic Purpura (ITP): A Highly Cost Effective Option in a Developing Country.
Authors: Ajay Sharma, Velu Nair, Satya R. Das, D.K. Mishra, J. Kotwal, Mohan B. Agarwal
Journal: Blood (2006)
Autologous Stem Cell Transplantation (ASCT) in HIV Associated Lymphoma (HIV-Ly) Patients: An Updated Analysis of the EBMT Lymphoma Working Party (EBMT-LWP) Experience.
Authors: Pascual Balsalobre, Jose L. Diez-Martin, Alessandro Re, Maria G. Michieli, Josep-Maria Ribera, Anne Rosselet, Eulogio Conde, Rosario Varela, Kate Cwynarski, Ian Gabriel, Philippe Genet, Gaelle Guillerm, Bernardino Allione, Augustin Ferrant, Marcus Hentrich, Pierre Biron, Dirk Meyer, Ildefonso Espigado, Ann E. Hunter, Manuel Jurado, Pascual Fernandez, Carmen Canals, Goli Taghipour, David Serrano, Anna Sureda
Journal: Blood (2007)
Low Molecular Weight Heparin during Surgery in Parients on Long Term Oral Anticoagulant Treatment (OAT): A Prospective Observational Study.
Authors: Francesco Baudo, Gianni Mostarda, Angelo Ghirarduzzi, Maurizio Molinatti, Vittorio Pengo, Daniela Poli, Alberto Tosetto, Eros Tiraferri, Enrica Morra
Journal: Blood (2004)
Accumulated mutations by 6 months of infection collectively render transmitted/founder HIV-1 significantly less fit
Authors: Chu Wang, Donglai Liu, Tao Zuo, Bhavna Hora, Fangping Cai, Haitao Ding, John Kappes, Christina Ochsenbauer, Wei Kong, Xianghui Yu, Tanmoy Bhattacharya, Alan S Perelson, Feng Gao
Journal: Journal of Infection (2019)
Association of Patient, Prescriber, and Region With the Initiation of First Prescription of Biologic Disease-Modifying Antirheumatic Drug Among Older Patients With Rheumatoid Arthritis and Identical Health Insurance Coverage
Authors: Mark Tatangelo, George Tomlinson, J. Michael Paterson, Vandana Ahluwalia, Alex Kopp, Tara Gomes, Nick Bansback, Claire Bombardier
Journal: JAMA Network Open (2019)

Prescribing the first biologic treatment for rheumatoid arthritis (RA) is an important decision for patients, their physicians, and payers, with considerable costs and clinical implications. Conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) have known effectiveness and safety profiles and are less expensive; therefore, determining the variables contributing to csDMARD treatment duration is an essential question for patients, physicians, and payers.To describe access to the first biologic DMARD prescription in a population of patients with RA and identical comprehensive health insurance coverage in Ontario, Canada, and to explore the associations of patient, prescriber, and geographic region with differences in time to first biologic prescription.This cohort study of incident patients with RA used administrative data with surveillance and patient-level data collected at yearly intervals. A total of 17 672 patients were included in the study; they were residents of Ontario, Canada, had an incident RA diagnosis at age 67 or older between 2002 and 2015, and received at least 1 csDMARD. Data were analyzed in November 2017.Patient variables were age, sex, disease duration, socioeconomic status, distance to care, and supply of care in the patient's area of residence. Prescriber covariates were year of graduation, specialty of practice, and supply of rheumatologic care in the patient's geographic region.Time from first csDMARD prescription to receipt of first biologic medication.Of 17 672 patients, 11 598 (65.6%) were women, and the mean (SD) age was 75.2 (5.8) years. Characteristics associated with longer time to receipt of a biologic prescription were older age (HR for every 5-year increase, 0.66; 95% CI, 0.62-0.71; P < .001), male sex (HR, 0.76; 95% CI, 0.66-0.89; P < .001), and distance to the nearest rheumatologist (HR per 10-km increase, 0.99; 95% CI, 0.98-0.99; P < .001). Prescribers were primarily rheumatologists (151 of 214 [70.6%]) and primary care physicians (26 of 214 [12.1%]). After adjusting for the number of patients eligible to receive biologic DMARDs, rheumatologists' preferences (ie, yearly prescription rates) for using biologic DMARDs increased over time, from 1.7% in 2001 to 4.9% in 2015. After adjusting for calendar year and patient-, prescriber-, and region-level characteristics, substantial variation between prescribers in rates of prescribing a first biologic DMARD were found (65% variance).This study found variation in time to receipt of first biologic DMARD after prescription of first csDMARD in a population with RA after adjustment for individual-level patient, prescriber, and geographic area covariates, despite identical universal health insurance coverage.
A Decade of Sexting Research
Authors: Joris Van Ouytsel
Journal: JAMA Pediatrics (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Dopamine-Mediated Yawning-Fatigue Syndrome With Specific Recurrent Initiation and Responsiveness to Opioids
Authors: Payam Dibaj, Knut Brockmann, Jutta Gärtner
Journal: JAMA Neurology (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
A Novel Cytotoxic Mechanism by Leukemia-Specific Antibody in Immunotherapy with Leukemia Cell-Derived Heat Shock Protein 70.
Authors: Kazuya Sato, Junko Jimbo, Takaaki Hosoki, Motohiro Shindo, Katsuya Ikuta, Yoshihiro Torimoto, Yutaka Kohgo
Journal: Blood (2007)
Integrative analysis of spontaneous CLL regression highlights genetic and microenvironmental interdependency in CLL
Authors: Marwan Kwok, Ceri Oldreive, Andy C. Rawstron, Anshita Goel, Grigorios Papatzikas, Rhiannon E. Jones, Samantha Drennan, Angelo Agathanggelou, Archana Sharma-Oates, Paul Evans, Edward Smith, Surita Dalal, Jingwen Mao, Robert Hollows, Naheema Gordon, Mayumi Hamada, Nicholas J. Davies, Helen Parry, Andrew D. Beggs, Talha Munir, Paul Moreton, Shankara Paneesha, Guy Pratt, A. Malcolm R. Taylor, Francesco Forconi, Duncan M. Baird, Jean-Baptiste Cazier, Paul Moss, Peter Hillmen, Tatjana Stankovic
Journal: Blood (2019)
Compound GW506U78 Has High Single-Drug Activity and Good Feasibility in Heavily Pretreated Relapsed T-Lymphoblastic Leukemia (T-ALL) and T-Lymphoblastic Lymphoma (T-LBL) and Offers the Option for Cure with Stem Cell Transplantation (SCT).
Authors: Nicola Goekbuget, Renate Arnold, Johannes Atta, Patrick Brück, Stella Hermann, Heinz Horst, Mustafa Kondakci, Roswitha Kotthoff, Oliver Ottmann, Thorsten Raff, Richard Ratei, Mathias Schmid, Michael Stadler, Dieter Hoelzer
Journal: Blood (2005)
Endoscopic ultrasound-guided rendezvous for access to the right posterior bile duct in a surgical candidate
Authors: Hirotoshi Ishiwatari, Tatsunori Satoh, Junya Sato, Junichi Kaneko, Katsuhisa Ohgi, Hiroyuki Matsubayashi, Katsuhiko Uesaka
Journal: Endoscopy (2019)

Endoscopic ultrasonography-guided rendezvous technique (EUS-RV) includes two approaches: the intrahepatic and extrahepatic bile duct approaches from the stomach and duodenum, respectively [1] [2]. However, the technique is impractical when drainage is required for right hepatic bile duct obstruction. Percutaneous transhepatic biliary drainage has a possible risk of tumor seeding in a patient with cholangiocarcinoma; therefore, it is not recommended for surgical candidates [3] [4] [5]. We present a case of successful drainage of the obstructed right posterior bile duct using EUS-RV ([Video 1]).
Atomic force microscopy measurements of anionic liposomes reveal the effect of liposomal rigidity on antigen-specific regulatory T cell responses
Authors: Naomi Benne, Romain J.T. Leboux, Marco Glandrup, Janine van Duijn, Fernando Lozano Vigario, Malene Aaby Neustrup, Stefan Romeijn, Federica Galli, Johan Kuiper, Wim Jiskoot, Bram Slütter
Journal: Journal of Controlled Release (2019)

Regulatory T cells (Tregs) are vital for maintaining a balanced immune response and their dysfunction is often associated with auto-immune disorders. We have previously shown that antigen-loaded anionic liposomes composed of phosphatidylcholine (PC) and phosphatidylglycerol (PG) and cholesterol can induce strong antigen-specific Treg responses. We hypothesized that altering the rigidity of these liposomes while maintaining their size and surface charge would affect their capability of inducing Treg responses. The rigidity of liposomes is affected in part by the length and saturation of carbon chains of the phospholipids in the bilayer, and in part by the presence of cholesterol. We used atomic force microscopy (AFM) to measure the rigidity of anionic OVA323-containing liposomes composed of different types of PC and PG, with or without cholesterol, in a molar ratio of 4:1(:2) distearoyl (DS)PC:DSPG (Young's modulus (YM) 3611 ± 1271 kPa), DSPC:DSPG:CHOL (1498 ± 531 kPa), DSPC:dipalmitoyl (DP)PG:CHOL (1208 ± 538), DPPC:DPPG:CHOL (1195 ± 348 kPa), DSPC:dioleoyl (DO)PG:CHOL (825 ± 307 kPa), DOPC:DOPG:CHOL (911 ± 447 kPa), and DOPC:DOPG (494 ± 365 kPa). Next, we assessed if rigidity affects the association of liposomes to bone marrow-derived dendritic cells (BMDCs) in vitro. Aside from DOPC:DOPG liposomes, we observed a positive correlation between liposomal rigidity and cellular association. Finally, we show that rigidity positively correlates with Treg responses in vitro in murine DCs and in vivo in mice. Our findings underline the suitability of AFM to measure liposome rigidity and the importance of this parameter when designing liposomes as a vaccine delivery system.
Gene Therapy for X-Linked Chronic Granulomatous Disease.
Authors: Marion G. Ott, Stefan Stein, Ulrike Koehl, Andrea Schilz, Klaus Kuhlcke, Manfred Schmidt, Christof von Kalle, Moustapha Hassan, Ulrich Siler, Dieter Hoelzer, Reinhard Seger, Manuel Grez
Journal: Blood (2004)
Minimum tolerable interval of <sup>90</sup>yttrium ibritumomab-tiuxetan to autologous stem cell transplantation after high-dose chemotherapy with carmustin, etoposide, cytarabine, and melphalan for relapsed or refractory aggressive B-cell non-Hodgkin lymphoma.
Authors: Justin Hasenkamp, Georg Hess, Bernd Hertenstein, Peter Dreger, Lutz Uharek, Martin Gramatzki, Jörg Schubert, Gerald Wulf, Lorenz Truemper, Norbert Schmitz, Bertram Glass
Journal: Journal of Clinical Oncology (2012)

6543 Background: High-dose therapy and autologous stem cell transplantation (ASCT) in patients (pts) with aggressive B-NHL failing from immunochemotherapy including rituximab show poor outcome with 3y PFS of 39% (Gisselbrecht et al. JCO 2010). Combining BEAM with 90 yttrium ibritumomab tiuxetan is a promising option to enhance the efficacy of the high-dose regimen. Methods: Pts without disease progression during salvage therapy of relapsed or refractory CD20+ aggressive B-NHL were included in this prospective, multicenter, phase I/II trial. Primary endpoint was the maximum tolerated dose of 90 Yttrium ibritumomab tiuxetan given as close as possible to ASCT defined as &lt;2 pts with dose limiting toxicity in a 6+6 pts cohort. First, we reduced the time interval of 90 yttrium ibritumomab tiuxetan (0.4 mCi/kg body weight) to ASCT from 14 to 12 and then 10 days. Subsequently it was planned to increase the 90 yttrium ibritumomab tiuxetan dose. Results: From 2006 to 2009 26 pts, median age 58y (34-66) were enrolled. Histology included 14 DLBCL, 6 FL III°, 5 transformed FL and 1 aggressive B-NHL without further subtyping. 11/26 pts had relapse/progression within 1y after diagnosis. Secondary IPI was &gt;1 in 14 pts. Response to salvage therapy was CR in 6/26 pts and PR in 12/26 pts. 20/26 pts achieved CR after ASCT. Engraftment showed no significant differences in pts of different cohorts with median recovery of leukocytes (&gt;1/nl) and platelets (&gt;25/nl) at d +10 and +13. Two early deaths (d +7, +18) occurred due to infections. 90 Yttrium ibritumomab tiuxetan (0.4 mCi/kg body weight) at d -10 of ASCT was determined as minimum tolerated interval of radioimmunotherapy to ASCT after BEAM. Median follow-up of the survivors is 3.3 y. 3y PFS and OS is 67% (95% CI, 49%-85%) and 75% (95% CI, 58%-92%), respectively. Main cause of death was relapse/progression with 27% (95% CI, 6%-38%) at 3y. Conclusions: Z-BEAM followed by ASCT was safe and feasible and results in a high response rate with durable remissions in rituximab pretreated patients with aggressive B-NHL. Extended studies at the maximum tolerated dose and confirmation of superiority compared to conventional ASCT are warranted.
Dll1 and Dll4 Notch Ligands Prime T Cell Alloimmunity and Are Expressed in Non-Overlapping Populations of Fibroblastic Stromal Cells in Spleen and Lymph Nodes at the Onset of Gvhd
Authors: Joshua D Brandstadter, Eric Perkey, Brian T. Gaudette, Léolène Carrington, Daniela Gomez-Atria, Bruce R. Blazar, Burkhard Ludewig, Anastasia Tikhonova, Iannis Aifantis, David Allman, Ivan Maillard
Journal: Blood (2019)
Prognosis Value of Flt3 Internal Tandem Duplication and P-Glycoprotein Functionality, in 171 AML.
Authors: Christophe Marzac, Irene Teyssandier, Jean Yves Perrot, Anne Marie Faussat, Ruoping Tang, Nicole Casadevall, Jean Pierre Marie, Ollivier Legrand
Journal: Blood (2005)
Results of a Phase III Double-Blind Study of the Addition of Tocilizumab Vs. Placebo to Cyclosporin/Methotrexate Gvhd Prophylaxis after HLA-Matched Allogeneic Stem Cell Transplantation
Authors: Glen A Kennedy, Siok-Keen Tey, Cameron Curley, Jason P Butler, Ashish Misra, Elango Subramoniapillai, James Morton, Simon Durrant, Andrea S Hendon, John Moore, David Ritchie, David Gottlieb, Julian Cooney, Luke Buizen, Sanjoy K Paul, Geoff R. Hill
Journal: Blood (2019)
Outcomes after HLA-Identical Sibling Allogeneic Peripheral Blood Stem Cell Transplantation Using Reduced Intensity Conditioning Compared to Autologous Peripheral Blood Stem Cell Transplantation for Elderly Patients with De Novo Acute Myeloid Leukemia.
Authors: Andree-Laure Herr, Myriam Labopin, Didier Blaise, Mike Potter, Felicetto Ferrara, Enric Carreras, William Arcese, Arnon Nagler, Norbert C. Gorin, Francesco Frassoni, Vanderson Rocha
Journal: Blood (2005)
Gurvitis syndrome: the dark shade of hematemesis
Authors: Cătălina Diaconu, Mihai Ciocîrlan, Mădălina Ilie, Vasile Sandru, Daniel Vasile Balaban, Oana Plotogea, Mircea Diculescu
Journal: Endoscopy (2019)

Gurvitis syndrome, also known as acute esophageal necrosis (AEN) or “black esophagus,” is a rare syndrome characterized by necrotic lesions affecting the mucosa and submucosa, mainly in the distal part of the esophagus. Prevalence is 0.2 % and incidence is 0.01 % – 0.0125 % among Caucasians [1] [2].