AB0750 INFLUENCE OF AXIAL INVOLVEMENT ON FREQUENCY OF ENTHESITIS AND DACTYLITIS, PATIENTS’ REPORTED OUTCOMES AND THEIR FUNCTIONAL CAPACITY. DATA FROM THE RUSSIAN PSORIATIC ARTHRITIS REGISTRY (RU-PSART)
Authors: Gubar Elena, Elena Loginova, Anastasia Koltakova, Yulia Korsakova, Tatiana Korotaeva, Evgeny Nasonov, Maria Sedunova, Igor Pristavsky, Irina Umnova, Irina Bondareva, Snezana Kudishina
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> The latest data show that axial involvement in psoriatic arthritis (PsA) patients (pts) is associated with significantly worse disease status and widespread impairment of patient-reported outcomes (PRO's) (1). <h3>Objectives</h3> To analyze clinical characteristics and PRO's in PsA pts with and without radiographic sacroiliitis (rSI) in the Russian Psoriatic arthritis Registry (RU-PsART).I <h3>Methods</h3> 385 pts (M/F–172/213) with PsA according to CASPAR criteria were included in the RU-PsART. Data was collected from 25 rheumatology clinics from various regions of the Russian Federation. Median age 45 (Min 20-Max 80) years (yrs), disease duration 3.4 yrs (4 months-32 yrs). Pts underwent standard clinical examination of PsA activity. All pts were studied for patient global disease activity (PGA) and patients' pain measured by Visual analogue Scale (VAS), and Health assessment Questionnaire (HAQ). Physician's global assessment of disease activity (PG) was measured by VAS. The examination included X-ray of sacroiliac joints (pelvic radiographs). rSI was defined as bilateral grade ≥2 or unilateral grade ≥3. Pts were split into two groups (gr.): those with rSI [rSI(+)] and those without rSI [rSI(-)]. Medians and quartiles [Me (Q25; Q75)], [Min; Max], U-test and ORs with 95% CI were performed. All CI &gt;1, p &lt;0.05 were considered to indicate statistical significance. Results: gr. rSI(+) included 214 (55.6%) cases (M/F–106/108), gr. rSI(-) included 171 (44.4%) cases (M/F–66/105). Median age in gr. rSI(+) was 45 [Min 20-Max 80] yrs, in gr. rSI(-) it was 46 [Min 21- Max 82] yrs. Significant differences were revealed between gr. rSI(+) and gr. rSI(-). <b><i>In Leeds Enthesitis index (LEI</i><i>)</i></b>: in gr. rSI(+) LEI was 0 [0-2], in gr. rSI(-) it was 0 [0-1] (p=0.02). <b><i>In frequency of dactylitis</i></b>: in gr. rSI(+) 71 pts had dactylitis, 143 did not have; in gr. rSI(-) 32 pts had dactylitis, 139 did not have. OR 2.2 [1.3-3.5].<b><i> in PGA:</i></b> in gr. rSI(+) it was 56.5 [42.3-70.0], in gr. rSI(-) it was 50.0 [30.0-60.0] (р= 0.00). <b><i>In patients' pain:</i></b> in gr. rSI(+) it was 50.0 [40.0-70.0], in gr. rSI(-) it was 50.0 [20.5-58.8] (р=0.00). <b><i>In PG:</i></b> in gr. rSI(+) it was 54.0 [40.0-69.5], in gr. rSI(-) it was 40.0 [25.5-50.0] (р=0.00). <b><i>In HAQ scores</i></b>: in gr. rSI(+) it was 1.0 [0.6-1.5], in gr. rSI(-) it was 0 [0-2.2] (р=0.02). <h3>Conclusion</h3> Axial involvement is identified in more than half (55.6%) of the PsA pts. The presence of axial involvement in PsA pts is associated with significantly worse disease status as measured by frequency of enthesitis and dactylitis, worse PRO's and with the reduction of patient's functional capacity. Consequently, the diagnostics of axial involvement is critical in clinical practice. <h3>References</h3> [1] P. J. Mease, et al. J Rheumatol2018;45:1389-96 <h3>Disclosure of interests</h3> ELENA GUBAR: None declared, Elena Loginova Speakers bureau: Novartis, Celgene Corporation, Biocad, Janssen, abbVie inc, anastasia Koltakova: None declared, Yulia Korsakova Speakers bureau: Celgene Corporation, Janssen, Tatiana Korotaeva Consultant for: Pfizer, MSD, Novartis, abbVie, Celgene, Biocad, Janssen, UCB, Lilly and Novartis-Sandoz, Speakers bureau: Pfizer, MSD, Novartis, abbVie, Celgene, Biocad, Janssen, UCB, Lilly and Novartis-Sandoz, Evgeny Nasonov Speakers bureau: Pfizer, inc., MSD, Novartis, abbVie inc., Celgen Corporation, Biocad, Janssen, UCB, inc., Maria Sedunova: None declared, Igor Pristavsky: None declared, Irina Umnova: None declared, Irina Bondareva: None declared, Snezana Kudishina: None declared