tbuckley/cabot-search huggingface dataset:
Radiomic features from PSMA PET for non-invasive intraprostatic tumor discrimination and characterization in patients with intermediate- and high-risk prostate cancer - a comparison study with histology reference
Authors: Constantinos Zamboglou, Montserrat Carles, Tobias Fechter, Selina Kiefer, Kathrin Reichel, Thomas F. Fassbender, Peter Bronsert, Goeran Koeber, Oliver Schilling, Juri Ruf, Martin Werner, Cordula A. Jilg, Dimos Baltas, Michael Mix, Anca L. Grosu
Journal: Theranostics (2019)

Purpose: To evaluate the performance of radiomic features (RF) derived from PSMA PET for intraprostatic tumor discrimination and non-invasive characterization of Gleason score (GS) and pelvic lymph node status.Patients and methods: Patients with prostate cancer (PCa) who underwent [ 68 Ga]-PSMA-11 PET/CT followed by radical prostatectomy and pelvic lymph node dissection were prospectively enrolled (n=20).Coregistered histopathological gross tumor volume (GTV-Histo) in the prostate served as reference.133 RF were derived from GTV-Histo and from manually created segmentations of the intraprostatic tumor volume (GTV-Exp).Spearman´s correlation coefficients (ρ) were assessed between RF derived from the different GTVs.We additionally analyzed the differences in RF values for PCa and non-PCa tissues.Furthermore, areas under receiver-operating characteristics curves (AUC) were calculated and uni-and multivariate analyses were performed to evaluate the RF based discrimination of GS 7 and ≥8 disease and of patients with nodal spread (pN1) and non-nodal spread (pN0) in surgical specimen.The results found in the latter analyses were validated by a retrospective cohort of 40 patients. Results:Most RF from GTV-Exp showed strong correlations with RF from GTV-Histo (86% with ρ>0.7).81% and 76% of RF from GTV-Exp and GTV-Histo significantly discriminated between PCa and non-PCa tissue.The texture feature QSZHGE discriminated between GS 7 and ≥8 considering GTV-Histo (AUC=0.93)and GTV-Exp (prospective cohort: AUC=0.91 / validation cohort: AUC=0.84).QSZHGE also discriminated between pN1 and pN0 disease considering GTV-Histo (AUC=0.85)and GTV-Exp (prospective cohort: AUC=0.87 / validation cohort: AUC=0.85).In uni-and multivariate analyses including patients of both cohorts QSZHGE was a statistically significant (p<0.01)predictor for PCa patients with GS ≥8 tumors and pN1 status.Conclusion: RF derived from PSMA PET discriminated between PCa and non-PCa tissue within the prostate.Additionally, the texture feature QSZHGE discriminated between GS 7 and GS ≥8 tumors and between patients with pN1 and pN0 disease.Our results support the role of RF in PSMA PET as a new tool for non-invasive PCa discrimination and characterization of its biological properties.
Abstract 116: Should We Target Caregivers for Cardiopulmonary Resuscitation Training?
Authors: Shir Lynn Lim, Pei Ting Tan, Yiong Huak Chan, Yi Quan Tan, Benjamin Leong
Journal: Circulation (2014)

Background: Majority of cardiac arrests occur at home. Yet, bystander cardiopulmonary resuscitation (CPR) is more often performed by strangers. Public CPR training, while increasing the number of p...
Vascular Ehlers-Danlos Syndrome
Authors: Michael Frank, Salma Adham, Stéphanie Seigle, Anne Legrand, Tristan Mirault, Pierrick Henneton, Juliette Albuisson, Nicolas Denarié, Jean-Michaël Mazzella, Elie Mousseaux, Emmanuel Messas, Pierre Boutouyrie, Xavier Jeunemaitre
Journal: Journal of the American College of Cardiology (2019)
PS-204-The relationship between FIB-4 progression and liver outcome among patients with type 2 diabetes mellitus: A population based hospital study
Authors: Lucia Parlati, Anais Vallet Pichard, Samir Bouam, Jean François Meritet, Alain Hernvann, Helene Fontaine, Marion Cororuge, Clemence Hollande, Philippe Sogni, Pol Stanislas, Emmanuel Tsochatzis, Vincent Mallet
Journal: Journal of Hepatology (2019)
Efflux pump inhibitors of clinically relevant multidrug resistant bacteria
Authors: Andraž Lamut, Lucija Peterlin Mašič, Danijel Kikelj, Tihomir Tomašič
Journal: Medicinal Research Reviews (2019)

Abstract Bacterial infections are an increasingly serious issue worldwide. The inability of existing therapies to treat multidrug‐resistant pathogens has been recognized as an important challenge of the 21st century. Efflux pumps are important in both intrinsic and acquired bacterial resistance and identification of small molecule efflux pump inhibitors (EPIs), capable of restoring the effectiveness of available antibiotics, is an active research field. In the last two decades, much effort has been made to identify novel EPIs. However, none of them has so far been approved for therapeutic use. In this article, we explore different structural families of currently known EPIs for multidrug resistance efflux systems in the most extensively studied pathogens (NorA in Staphylococcus aureus , AcrAB‐TolC in Escherichia coli , and MexAB‐OprM in Pseudomonas aeruginosa ). Both synthetic and natural compounds are described, with structure‐activity relationship studies and optimization processes presented systematically for each family individually. In vitro activities against selected test strains are presented in a unifying manner for all the EPIs described, together with the most important toxicity, pharmacokinetic and in vivo efficacy data. A critical evaluation of lead‐likeness characteristics and the potential for clinical development of the most promising inhibitors of the three efflux systems is described. This overview of EPIs is a good starting point for the identification of novel effective antibacterial drugs.
Four Cases of Cholesterol Management Informed by the 2018 American Heart Association/American College of Cardiology Multisociety Guideline on the Management of Blood Cholesterol
Authors: Sarah Chuzi, Anna Pfenniger, Donald M. Lloyd-Jones, Roger S. Blumenthal, Sidney C. Smith, Salim S. Virani, Scott M. Grundy, Neil J. Stone
Journal: JAMA Cardiology (2019)

These 4 hypothetical cases highlight some of the new features in the 2018 American Heart Association/American College of Cardiology multisociety cholesterol management guidelines. Topics include management issues in a secondary prevention patient judged to be at very high risk of another event, a patient with familial hypercholesterolemia with a low-density lipoprotein cholesterol level of 190 mg/dL or greater (to convert to millimoles per liter, multiply by 0.0259), a primary prevention patient with intermediate (7.5%-19.9%) 10-year atherosclerotic cardiovascular risk, and a patient who has statin-associated adverse effects. A multiple-choice format is used to engage clinicians in selecting the best choice based on guidance from the new 2018 cholesterol management guidelines.
THU-062-Exploring the immune environment in chronic hepatitis C associated fibrosis by examining the portal vein
Authors: Rabab Oun Ali Anwar Ali, Ohad Etzion, Grace Zhang, Elizabeth Townsend, Gabriella quinn, kareen hill, Christopher Koh, kimberly romito, Joseph Monsale, Jennifer stoddard, Shakuntala Rampertaap, Elliot Levy, David E Kleiner, Sergio Rosenzweig, Theo Heller
Journal: Journal of Hepatology (2019)
Association of Chemerin Plasma Concentration With Risk of Colorectal Cancer
Authors: Fabian Eichelmann, Matthias B. Schulze, Clemens Wittenbecher, Juliane Menzel, Cornelia Weikert, Romina di Giuseppe, Ronald Biemann, Berend Isermann, Andreas Fritsche, Heiner Boeing, Krasimira Aleksandrova
Journal: JAMA Network Open (2019)

<h3>Importance</h3> Inflammatory processes have been suggested to have an important role in colorectal cancer (CRC) etiology. Chemerin is a recently discovered inflammatory biomarker thought to exert chemotactic, adipogenic, and angiogenic functions. However, its potential link with CRC has not been sufficiently explored. <h3>Objective</h3> To evaluate the prospective association of circulating plasma chemerin concentrations with incident CRC. <h3>Design, Setting, and Participants</h3> Prospective case-cohort study based on 27 548 initially healthy participants from the European Prospective Investigation Into Cancer and Nutrition (EPIC)–Potsdam cohort who were followed for up to 16 years. Baseline study information and samples were collected between August 23, 1994, and September 25, 1998. Recruitment was according to random registry sampling from the geographical area of Potsdam, Germany, and surrounding municipalities. The last date of study follow-up was May 10, 2010. Statistical analysis was conducted in 2018. <h3>Main Outcomes and Measures</h3> Incident CRC, colon cancer, and rectal cancer. Baseline chemerin plasma concentrations were measured by enzyme-linked immunosorbent assay. <h3>Results</h3> A random subcohort of 221 incident CRC cases and 2329 participants free of CRC with available blood sample measurements were included in the analysis. The participants' mean (SD) age was 50 (9) years, 62.1% were female, and 16.5% had a body mass index greater than 30. In multivariable-adjusted Cox proportional hazards regression models taking into account established CRC risk factors, higher chemerin concentrations were associated with a greater risk of CRC, with a hazard ratio (HR) of 1.81 (95% CI, 1.08-3.05;<i>P</i>for trend = .007) for the highest chemerin quartile vs the lowest. Analyses by cancer subsite indicated a stronger association with colon cancer (HR, 2.27; 95% CI, 1.18-4.34 for the highest quartile vs the lowest;<i>P</i>for trend = .005) compared with rectal cancer (HR, 1.27; 95% CI, 0.57-2.85;<i>P</i>for trend = .35). The association was particularly strong for proximal colon cancer (HR, 3.97; 95% CI, 1.51-10.50;<i>P</i>for trend = .001). <h3>Conclusions and Relevance</h3> This study found that the association between chemerin concentration and the risk of incident CRC was linear and independent of established CRC risk factors. Further studies are warranted to evaluate chemerin as a novel immune-inflammatory agent in colorectal carcinogenesis.
THU-159-Real-world efficacy of elvasvir and grazoprevir for hepatitis C virus (genotype 1): A nationwide, multicenter study by the Japanese Red Cross Hospital Liver Study Group
Authors: Toshie Mashiba, Kouji Joko, Hironori Ochi, Ryo Yano, Kaori Sato, Yusuke Okujima, Michiko Aono, Nobuaki Azemoto, Tomoyuki Yokota, Masayuki Kurosaki, Namiki Izumi
Journal: Journal of Hepatology (2019)
SAT-120-Influence of previous acute decompensation and organ failure on the long-term prognosis in cirrhotic patients with decompensation
Authors: Do Seon Song, Tae Yeob Kim, Eileen L Yoon, Jin Mo Yang, Hee Yeon Kim, Chang Wook Kim, Young Kul Jung, HyungJoon Yim, Soung Won Jeong, sang gyune kim, Jae Young Jang, Moon Young Kim, Dong Hyun Sinn, KI TAE Suk, Dong Joon Kim
Journal: Journal of Hepatology (2019)
How Do Multiple Symptoms <i>Really</i> Affect Older Adults?
Authors: Rebecca Voelker
Journal: JAMA (2019)

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SAT-299-Assessment of NIS4 clinical utility for identification of patients with active NASH (NAS ≥ 4) and significant fibrosis (F ≥ 2) in patients at risk of NASH
Authors: Remy Hanf, Pierre Chaumat, Zouher Majd, Genevieve Cordonnier, John Brozek, Emilie Praca, Fouad Ben Sudrik, Prof. Pierre Bedossa, Prof. Quentin M. Anstee, Prof. Sven Francque, Prof. Stephen A. Harrison, Prof. Vlad Ratziu, Sophie Mégnien, Alice Roudot, Suneil Hosmane, Dean W. Hum, Arun J. Sanyal
Journal: Journal of Hepatology (2019)
Association Among Dietary Supplement Use, Nutrient Intake, and Mortality Among U.S. Adults
Authors: Fan Chen, Mengxi Du, Jeffrey B. Blumberg, Kenneth Kwan Ho Chui, Mengyuan Ruan, Gail Rogers, Zhilei Shan, Luxian Zeng, Fang Fang Zhang
Journal: Annals of Internal Medicine (2019)

The health benefits and risks of dietary supplement use are controversial.
Perioperative chemotherapy with cisplatin (CP) and doxorubicin (DOX) with and without high-dose methotrexate (HDM) in adult osteosarcoma (AOT): Is methotrexate warranted?
Authors: Lucila Soares Da Silva Rocha, Marcelo Vailati Negrao, Daniel da Motta Girardi, Veridiana Pires De Camargo, Luciana Bastos Valente Alban, Paulo Marcelo Hoff, Olavo Feher
Journal: Journal of Clinical Oncology (2015)

10523 Background: treatment of AOT consists of perioperative chemotherapy and surgical resection. Standard chemotherapy in AOT consists of CP and DOX. Although considered standard of care in the pediatric population, the use of HDM remains controversial in adults. In addition, it is associated with greater toxicity rates, leading many specialized centers to drop it. This study aims to review treatment efficacy in localized AOT treated at our institution to ascertain the role of HDM in this disease. Methods: this retrospective study included consecutive patients with localized AOT treated at the Instituto do Cancer do Estado de São Paulo (ICESP) from 2008 to 2014 that received at least one perioperative chemotherapy cycle. Chemotherapy regimens consisted of DOX and CP (group 1). A subgroup of patients also received HDM (group 2). Analysis of overall survival (OS), disease free survival (DFS) and treatment toxicities were performed. Results: final analysis included 26 patients, 16 treated in group 1 and 10 in group 2. Most patients presented ECOG performance status 0-2 (93.8 and 80%) and lower extremity primary tumours (62.5 and 80.0%), for group 1 and group 2 respectively. Despite lower average age (35.0±12.1 and 18.9±2.1 y), group 2 presented more grade (G) 3/4 thrombocytopenia (0 and 15.8%) and G3/4 mucositis (0 and 21.1%), while group 1 presented more neutropenia G3/4 (46.6 and 26.3%). Both groups presented no G3/4 renal toxicities. Two grade 5 toxicities occurred in group 2 (bleeding and neutropenia), both after the first HDM cycle. Efficacy analysis revealed no difference in DFS (4.38±0.61 and 2.3±0.54y, p = 0.228) and OS between groups (4.70±0.56 and 2.52±0.57y, p = 0.107), with a trend to better outcomes in group 1. The 4-year OS was 65.6 and 32.8% for group 1 and 2 respectively. Conclusions: HDM chemotherapy was associated with greater severe and lethal toxicity when added to CP and DOX perioperative chemotherapy in AOT. In addition, it does not seem to impact on efficacy. This data does not support the use of HDM in the treatment of AOT.
THU-348-Patients with non-alcoholic steatohepatitis experience severe impairment of health related quality of life
Authors: Zobair Younossi, Maria Stepanova, Eric Lawitz, Rajender Reddy, Vincent Wai-Sun Wong, Alessandra Mangia, Andrew Muir, Stephen Djedjos, Anuj Gaggar, Robert Myers, Issah Younossi, Fatema Nader, Andrei Racilla
Journal: Journal of Hepatology (2019)
Feasibility of administering a geriatric assessment to older adults with cancer using web-based and touchscreen platforms.
Authors: Jerome G. Kim, Chie Akiba, Dale Mitani, David D. Smith, Matthew J. Loscalzo, Stephen J. Forman, Marianna Koczywas, Sumanta Kumar Pal, Vincent M. Chung, Nitya Nathwani, Marwan Fakih, Leslie Popplewell, Betty R. Ferrell, Vani Katheria, Arti Hurria
Journal: Journal of Clinical Oncology (2015)

9536 Background: A geriatric assessment (GA) can help identify factors that increase the risk for chemotherapy-related toxicity in older patients with cancer. A GA has been developed which is primarily self-completed by patients using a paper and pencil questionnaire. With the shift to electronic medical records and the prospects of Big Data, a transition to an electronic GA is imperative to allow convenient deployment of this tool. The goal of this study is to 1) evaluate the feasibility of capturing patient reported GA data using 2 separate computer-based applications: web-based (REDCap [RC]) and a touchscreen (Support Screen [SS]), and 2) compare the computer responses to those obtained via paper-pencil. Methods: Patients (pts) aged > 65 yrs with cancer were eligible. Pts were randomized to 1 of 4 arms (RC /Paper; RC / RC; SS/Paper; SS/SS). The feasibility of each computer methodology was determined by the % of pts who could complete the GA independently, time to complete the GA (first time), and pt satisfaction with the survey platform. Correlations between the paper version and electronic version responses were evaluated. Results: 100 pts were accrued: median age 72 yrs (65-92 yrs), 51% female, and 63% stage IV disease. Primary cancers included lung (22%), breast (21%), GU (20%), GI (17%), and leukemia (9%). Pts’ self-reported computer skills were None + Beginner (N+B, 42%) or Intermediate + Advanced (57%). The mean (SD) time to completion using RC, SS, and Paper were 23 (8), 17 (7), and 16 (5) mins. Pts with limited computer skills (N+B) were able to complete the electronic assessment independently: RC (75%), SS (100%), and preferred the computer version over the paper survey (RC 67%, SS 76%). The correlations between the paper version and the electronic versions (SS, RC) were 0.91, 0.96 for Instrumental Activities of Daily Living and 0.82, 0.96 for Medical Outcomes Survey-Physical Health scales, respectively. Conclusions: The majority of patients in this cohort could complete an electronic GA using either a web-based or touchscreen platform independently. A higher proportion of patients preferred the touchscreen methodology. The electronic versions have high reproducibility compared to the paper GA.
PS-086-Sustained virologic response in patients with cirrhosis from chronic hepatitis C leads to sustained and long-term improvement of health-related quality of life, fatigue, and work productivity
Authors: Zobair Younossi, Maria Stepanova, Andrei Racilla, Ira Jacobson, Andrew Muir, Stefan Zeuzem, Eric Lawitz, Stanislas Pol, Anuj Gaggar, Robert Myers, Issah Younossi, Fatema Nader
Journal: Journal of Hepatology (2019)
Do two lungs form an integrated immune system? Learning from BALF examination in lung cancer
Authors: J. Domagala-Kulawik, T. Skirecki, D. Dziedzic, M. Polubiec-Kownacka, T. Kryczka, I. Kwiecien
Journal: Annals of Oncology (2019)

Background: Bronchoalveolar lavage fluid (BALF) examination was found to be useful in the evaluation of local immune status in the site of lung cancer development. This procedure may be performed during lung cancer diagnosis and repeated during therapy. It especially concerns the majority of lung cancer cases, which are beyond the possibility of resection at recognition. However, the procedure of BAL in the lung affected by cancer is often complicated. The aim of this study was an analysis of differences in the character of immune response between the lung affected by cancer versus the opposite, 'healthy' lung. May BALF from the lung free of tumor serve for the characterization of local immune status? Methods: BALF of 36 patients was harvested from the lung affected by cancer and opposite site: the lung without tumor. BALF cells were analyzed by means of the following sets of antibodies anti: the first probe CD4, CD127, CD25, Foxp3, CTLA4, the second probe: CD3, CD16/CD56, CD45, CD19, CD8. For macrophage phenotyping the immunofluorescent method with antibodies anti: CCR7 and CD163 was used. The concentrations of 27 cytokines were analyzed in the duplicate using Bio-Plex Pro Human Cytokine Assay. The next part of the study was performed in other 32 patients by the same method with a panel of antibodies anti: CD3, CD4, CD8, CD127, CD45RA, CD69, CTLA-4, PD-1. Results: By the analysis of the BALF profile we found that only the cells and cytokines involved in regulatory pathways showed significant differences between both the 'healthy' and the cancerous lung, being elevated in the latter. The proportion of Tregs, CTLA4+Tregs, activated and memory PD-1+ lymphocytes, CCR7lowCD163high macrophages were significantly higher in the lung with cancer than in the healthy lung. On the other hand, the proportion of effectory cells and inflammatory cytokines concentration did not differ between both lungs, which may indicate that they form an integrated immune system and individual homeostasis. Conclusions: Regulatory mechanisms which are up-regulated in the tumourbearing lung affect BALF profile in the lung with cancer, while the examination of BALF from the "healthy" lung may serve for the evaluation of individual basic profile of the anti-cancer response. Legal entity responsible for the study: The authors. Funding: Has not received any funding. Disclosure: J. Domagala-Kulawik: Travel grant, consultant: BMS, MSD. All other authors have declared no conflicts of interest.
Abstract 20817: Pharmacological Activation of Nuclear Receptor Nur77 Attenuates Experimental Pulmonary Arterial Hypertension by Modulating BMP Signaling
Authors: Kondababu Kurakula, Xiao-Qing Sun, Chris Happé, Christophe Guignabert, Harm Jan Bogaard, Marie-Jose Goumans
Journal: Circulation (2017)

Rationale: Pulmonary arterial hypertension (PAH) is a severe disease characterized by excessive proliferation of endothelial (EC) and smooth muscle cells (SMCs), and impaired BMP signalling in small lung arteries, resulting in increased vascular resistance and subsequent right ventricle failure. Furthermore, inflammation plays a crucial role in the initiation and maintenance of pulmonary vascular remodeling in PAH. Nuclear receptor Nur77 has been shown to inhibit proliferation of vascular cells and inflammation. In addition, Nur77 has been shown to modulate TGFβ/BMP pathway in a cell-and context- dependent manner. Collectively, given the effects of Nur77 on inflammation, SMC and EC, we hypothesized that activation of Nur77 may become a promising treatment of PAH. Methods: Primary pulmonary ECs and SMCs, lung tissue sections from control, hereditary- and idiopathic- PAH lungs, and rat models of Sugen-hypoxia and MCT-induced pulmonary hypertension (PH) were used. Immunohistochemical, quantitative PCR, weste...
THU-258-Comparison of a fast corticosteroid tapering with the standard corticosteroid schedule in severe alcoholic hepatitis
Authors: Berta Cuyas, Elida Oblitas, Marc Batlle, Gerard Suris, Alberto Amador, Margarita Sala, Helena Masnou, José Castellote, Nuria Cañete, Eva Roman, Carlos Guarner, German Soriano, Maria Poca
Journal: Journal of Hepatology (2019)