tbuckley/cabot-search huggingface dataset:
Association of Sensory Impairments With Cognitive Decline and Depression Among Older Adults in China
Authors: Hongguo Rong, Xiaozhen Lai, Rize Jing, Xiao Wang, Hai Fang, Elham Mahmoudi
Journal: JAMA Network Open (2020)

Sensory impairments may heighten the risk of premature brain aging. Little is known regarding the association of sensory impairments with cognitive function and depression in China.To examine the association of visual and/or hearing impairments with cognitive decline and depression.This cross-sectional study used the data from 18 038 respondents to the 2015 survey of the China Health and Retirement Longitudinal Study, a nationally representative survey of adults aged 45 years or older and their spouses.The presence of sensory impairments was identified by self-reported assessment of visual and/or hearing functions.Overall, 3 composite measures were used to assess the respondents' cognitive performance, including episodic memory, mental intactness, and global cognitive function. Depression was examined using the 10-item Center for Epidemiological Studies-Depression scale score. Multiple generalized linear regression models, adjusting for self-reported sociodemographic characteristics, health behaviors, chronic conditions, and participants' overall health, were used.Of 18 038 respondents, 9244 (51.2%) were women. The mean (SD) age was 59.9 (9.7) years. Respondents with visual impairment had poorer episodic memory (β = -0.12; 95% CI, -0.19 to -0.05) and global cognition (β = -0.16; 95% CI, -0.31 to -0.02) and a greater risk of depression (odds ratio, 1.78; 95% CI, 1.59 to 1.99) than those without visual impairment. Respondents with hearing impairment had poorer episodic memory (β = -0.24; 95% CI, -0.30 to -0.18), mental intactness (β = -0.19; 95% CI, -0.28 to -0.10), and global cognition (β = -0.43; 95% CI, -0.55 to -0.31) as well as a greater risk of depression (odds ratio, 1.57; 95% CI, 1.44 to 1.70) than those without hearing impairment. People who reported dual sensory impairment performed worse on all of the aforementioned outcome measures (episodic memory: β = -0.23; 95% CI, -0.31 to -0.14; mental intactness: β = -0.13; 95% CI, -0.27 to -0.0003; global cognition: β = -0.37; 95% CI, -0.55 to -0.19; depression: odds ratio, 2.19; 95% CI, 1.90 to 2.52).In this study, visual and hearing impairments were independently and together associated with poorer cognitive and depression outcomes. A more comprehensive and integrated system of care, covering vision, hearing, and cognition, is needed in China's health care system to address age-related sensory impairments.
Increased dopamine and its receptor dopamine receptor D1 promote tumor growth in human hepatocellular carcinoma
Authors: Yan Yan, Jiahao Pan, Yonghua Chen, Wei Xing, Qiang Li, Dongyin Wang, Xiaoshuang Zhou, Jingdun Xie, Changhong Miao, Yunfei Yuan, Weian Zeng, Dongtai Chen
Journal: Cancer Communications (2020)

Abstract Background Dopamine and dopamine receptor D1 (DRD1), a member of the dopamine receptor family, have been indicated to play important roles in cancer progression, but dopamine secretion in hepatocellular carcinoma (HCC) and the effects of DRD1 on HCC remain unclear. This study was designed to explore the contribution of the dopaminergic system to HCC and determine the relationship between DRD1 and prognosis in HCC patients. Methods The dopamine metabolic system was monitored using enzyme‐linked immunosorbent assays (ELISAs). The expression of DRD1 was detected by microarray analysis, immunohistochemistry (IHC), and quantitative real‐time PCR (qRT‐PCR). Stable DRD1 knockout and overexpression cell lines were established for investigation. Transwell, colony formation, and Cell Counting Kit 8 (CCK8) assays were performed to assess the malignant behaviors of cancer cells. The cAMP/PI3K/AKT/ cAMP response element‐binding (CREB) signaling pathway was evaluated by Western blot. This pathway, which is agitated by DRD1 in striatal neurons, had been proven to participate in tumor progression. Xenograft HCC tumors were generated for in vivo experiments. Results Dopamine secretion increased locally in HCC due to an imbalance in dopamine metabolism, including the upregulation of dopa decarboxylase (DDC) and the downregulation of monoamine oxidase A (MAOA). Dopamine promoted the proliferation and metastasis of HCC. DRD1 was highly expressed in HCC tissues and positive DRD1 expression was related to a poor prognosis in HCC patients. The upregulation of DRD1 agitated malignant activities, including proliferation and metastasis in HCC by regulating the cAMP/PI3K/AKT/CREB pathway, and the downregulation of DRD1 had opposing effects. The effects of dopamine on HCC was reversed by depleting DRD1. SCH23390, a selective DRD1 antagonist, inhibited the proliferation and metastasis of HCC cells both in vitro and in vivo . Conclusion Dopamine secretion was locally increased in HCC and promoted HCC cell proliferation and metastasis. DRD1 was found to exert positive effects on HCC progression and play a vital role in the dopamine system, and could be a potential therapeutic target and prognostic biomarker for HCC.
Fluorescence in situ hybridization analysis of t(3; 12)(q26; p13): a recurring chromosomal abnormality involving the TEL gene (ETV6) in myelodysplastic syndromes
Authors: SD Raynaud, M Baens, J Grosgeorge, K Rodgers, CD Reid, M Dainton, M Dyer, JG Fuzibet, N Gratecos, B Taillan, N Ayraud, P Marynen
Journal: Blood (1996)
Using Genetics to Increase Specificity of Outcome Prediction in Psychiatric Disorders: Prospects for Progression
Authors: Peter A. Holmans
Journal: American Journal of Psychiatry (2020)

fo r p r o g r e s sio n.Am e ri c a n Jou r n al of P syc hi a t ry 1 7 7 (1 0) , p p .8 8 4-8 8 7. 1 0. 1 1 7 6/ a p pi. aj p. 2 0 2 0.
Inflammation and intussusceptive angiogenesis in COVID-19: everything in and out of flow
Authors: Maximilian Ackermann, Steven J. Mentzer, Martin Kolb, Danny Jonigk
Journal: European Respiratory Journal (2020)

We recently showed that SARS-CoV-2 infection leads to angiocentric inflammation in COVID-19-induced respiratory failure, with a greater number of ACE2-positive endothelial cells compared to uninfected controls or to post mortem lung tissue from patients who succumbed to influenza A-related acute respiratory distress syndrome (ARDS) [1]. Although the detection of SARS-CoV-2 in post mortem tissue by transmission electron microscopy is a challenging task [4], replicated virus-like particles were observed enveloped in endothelial cells [1, 5] and lymphatic cells [6], and also in type 2 and 1 pneumocytes [6, 7]. Increasing clinical evidence shows that endothelial dysfunction is a common denominator after SARS-CoV-2 infection in the multi-organ complexity and severity of COVID-19 [3]. Inflammation and intussusceptive angiogenesis in COVID-19 <https://bit.ly/30lLh8K>
Role of <i>Helicobacter pylori</i> in gastric diseases pathogenesis cannot be ignored
Authors: Xianzhu Zhou, Huiyun Zhu, Yan Chen, Zhaoshen Li, Yiqi Du
Journal: Gut (2020)

We read with interest the study by Guo et al , evaluating the risk of gastrointestinal bleeding (GIB) in aspirin users after Helicobacter pylori eradication.1 It revealed a higher risk of GIB in new aspirin users even after H. pylori eradication than chronic aspirin users as well as non-users. The propensity score matching method was also performed to balance the potential differences of baseline characteristics among groups, which largely compensate for the deficiencies of retrospective research. However, the prevalence of H. pylori infection among Chinese population remains high (40%–60%).2 3 We hope to explicitly demonstrate the relationship between H. pylori infection and gastric diseases to justify the necessity of H. pylori eradication.

In our recent retrospective study, a …
Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion
Authors: Yi-Ru Yu, Hana Imrichova, Haiping Wang, Tung Chao, Zhengtao Xiao, Min Gao, Marcela Rincon-Restrepo, Fabien Franco, Raphael Genolet, Wan-Chen Cheng, Camilla Jandus, George Coukos, Yi-Fan Jiang, Jason W. Locasale, Alfred Zippelius, Pu-Ste Liu, Li Tang, Christoph Bock, Nicola Vannini, Ping-Chih Ho
Journal: Nature Immunology (2020)
Pembrolizumab followed by AVD in untreated early unfavorable and advanced-stage classical Hodgkin lymphoma
Authors: Pamela B. Allen, Hatice Savas, Andrew M. Evens, Ranjana H. Advani, Brett Palmer, Barbara Pro, Reem Karmali, Eric Mou, Jeffrey Bearden, Gary Dillehay, Robert A. Bayer, Robert M. Eisner, Joan S. Chmiel, Kaitlyn O’Shea, Leo I. Gordon, Jane N. Winter
Journal: Blood (2020)
David Oliver: Misusing the “criteria to reside” for hospital inpatients
Authors: David Oliver
Journal: BMJ (2020)

David Oliver: Misusing the "criteria to reside" for hospital inpatients David Oliver consultant in geriatrics and acute general medicineWe now face a potential second wave of the covid-19 pandemic and a backlog of elective work, and it is critical to avoid overcrowding and pressure on beds to prevent cross infection and further cancellation of services.Whose job is it to decide when patients are ready to leave hospital, with their families and community services able to support them?Recent guidance from NHS England on hospital discharge for all NHS trusts and social care staff goes further than ever. 1
courvoisier's law
Authors: Kacper Niburski
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gene Expression Signatures of BRCAness and Tumor Inflammation Define Subgroups of Early-Stage Hormone Receptor–Positive Breast Cancer Patients
Authors: Werner Schroth, Florian A. Büttner, Siarhei Kandabarau, Reiner Hoppe, Peter Fritz, Jörg Kumbrink, Thomas Kirchner, Heather A. Brauer, Yuqi Ren, David Henderson, Stephen F. Madden, Georg Sauer, Tanja Fehm, Diethelm Wallwiener, Peter A. Fasching, Thomas Mürdter, Matthias Schwab, Hiltrud Brauch
Journal: Clinical Cancer Research (2020)

Abstract Purpose: Patients with estrogen receptor– and/or progesterone receptor–positive, early breast cancer benefit from hormonal treatment, yet high global death burdens due to high prevalence and long-term recurrence risk call for biomarkers to guide additional treatment approaches. Experimental Design: From a prospective, observational study of postmenopausal early breast cancer patients treated with tamoxifen or aromatase inhibitors, gene expression analyses of 612 tumors was performed using the NanoString Breast Cancer 360 panel to interrogate 23 breast cancer pathways. Candidate signatures associated with disease subtype and event-free survival (EFS) were obtained by cluster analysis, Cox modeling, and conditional inference trees, and were independently tested in 613 patients from BreastMark. Tumor-infiltrating lymphocytes (TIL) were assessed on tissue sections, and mutational burden was assessed in 36 tumors by whole-exome sequencing. Results: PAM50-derived classification distinguished lower-risk (Luminal A) from higher-risk subtypes (Luminal B, P = 0.04; HER2, P = 0.006; Basal, P = 0.008). In higher-risk patients, shorter EFS was associated with low androgen receptor [HR = 3.61; 95% confidence interval (CI), 1.72–7.56; P = 0.001] or high BRCAness signature expression (HR = 3.58; 95% CI, 1.19–10.7; P = 0.023). BRCAness was independently confirmed as a predictor of shorter EFS (HR = 2.64; 95% CI, 1.31–5.34; P = 0.007). About 13%–15% of patients, enriched for high-grade, higher-risk subtypes (P ≤ 0.0001), had strong expression of the Tumor Inflammation Signature (TIS) suggestive of an inhibited antitumor immune response. TIS scores were strongly associated with TIL numbers (P &amp;lt; 1e-30) but not with tumor mutation status. Conclusions: BRCA-related DNA repair deficiency and suppressed tumor immune responses may be clinically relevant predictors of endocrine therapy complementing treatment options in subgroups of hormone-sensitive early breast cancer.
Population Genomics Reveals Incipient Speciation, Introgression, and Adaptation in the African Mona Monkey (<i>Cercopithecus mona</i>)
Authors: Adeola Oluwakemi Ayoola, Bao-Lin Zhang, Richard P Meisel, Lotanna M Nneji, Yong Shao, Olanrewaju B Morenikeji, Adeniyi C Adeola, Said I Ng’ang’a, Babafemi G Ogunjemite, Agboola O Okeyoyin, Christian Roos, Dong-Dong Wu
Journal: Molecular Biology and Evolution (2020)

Guenons (tribe Cercopithecini) are the most widely distributed nonhuman primate in the tropical forest belt of Africa and show considerable phenotypic, taxonomic, and ecological diversity. However, genomic information for most species within this group is still lacking. Here, we present a high-quality de novo genome (total 2.90 Gb, contig N50 equal to 22.7 Mb) of the mona monkey (Cercopithecus mona), together with genome resequencing data of 13 individuals sampled across Nigeria. Our results showed differentiation between populations from East and West of the Niger River ∼84 ka and potential ancient introgression in the East population from other mona group species. The PTPRK, FRAS1, BNC2, and EDN3 genes related to pigmentation displayed signals of introgression in the East population. Genomic scans suggest that immunity genes such as AKT3 and IL13 (possibly involved in simian immunodeficiency virus defense), and G6PD, a gene involved in malaria resistance, are under positive natural selection. Our study gives insights into differentiation, natural selection, and introgression in guenons.
A new approach to automated affinity tagged protein purification
Authors: Mark Berardini
Journal: Cancer Research (2007)

LB-305  Purification of affinity tagged recombinant proteins is a critical first step for downstream functional and structural studies in many cancer research laboratories. Two commonly used affinity tags for the purification of recombinant proteins include the glutathione-S-transferase (GST) and poly-histidine (His) tags. An automated chromatography instrument has been developed for fast, reproducible, and cost-effective purification of both GST and His-tagged proteins. The system is configured for tandem chromatography applications and can perform time saving affinity purifications with integrated desalting (buffer exchange) in a single run. The system provides a complete set of chromatography buffers and affinity cartridges that have been optimized for GST and IMAC (immobilized metal affinity chromatography) separations. A user-friendly touch screen interface allows users to select pre-programmed chromatography methods or to customize methods for specific applications. The system is specifically designed for ease of use and for the unattended purification of 1-100 mg of GST or His-tagged proteins. Following purifications, instrument and column cleaning routines are performed to ensure optimal system performance. Representative purifications of GST tagged proteins using pre-programmed methods as well as custom methods designed to increase overall yield of purified protein are presented.
Becoming a Real Doctor
Authors: Rana Garris
Journal: Annals of Internal Medicine (2020)

On Being a Doctor6 October 2020Becoming a Real DoctorRana Garris, MDRana Garris, MDSt. Joseph's Regional Medical Center, Paterson, New Jersey (R.G.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M19-2204 Audio Reading - “Becoming a Real Doctor” Audio. Virginia L. Hood, MD, a physician from the University of Vermont, reads “Becoming a Real Doctor” by Rana Garris, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail At some point, every intern becomes a real doctor. It occurs in the least expected way, at the most inconvenient time. It occurs when you aren't ready. When you are exhausted. When they ask for their doctor, and the nurse pages you. When being confident is no longer an option. They want answers to questions that you don't know. How long until he dies? When will we know? Why did this happen? What can we do? They latch on to your every word, never quite satisfied.They teach you that being a real doctor isn't a stamp on your diploma. ... Author, Article, and Disclosure InformationAffiliations: St. Joseph's Regional Medical Center, Paterson, New Jersey (R.G.)Corresponding Author: Rana Garris, MD, St. Joseph's Regional Medical Center, 703 Main Street, Paterson, NJ 07503; e-mail, [email protected]hmc.org. PreviousarticleNextarticle Advertisement Audio Reading - “Becoming a Real Doctor” Audio. Virginia L. Hood, MD, a physician from the University of Vermont, reads “Becoming a Real Doctor” by Rana Garris, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 6 October 2020Volume 173, Issue 7Page: 584KeywordsNurses ePublished: 6 October 2020 Issue Published: 6 October 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Left Atrial Strain and Subclinical Cerebrovascular Disease in Older Adults
Authors: Carlo Mannina, Aylin Tugcu, Zhezhen Jin, Cesare Russo, Kenji Matsumoto, Kazato Ito, Shunichi Homma, Mitchell S.V. Elkind, Tatjana Rundek, Mitsuhiro Yoshita, Charles DeCarli, Clinton B. Wright, Ralph L. Sacco, Marco R. Di Tullio
Journal: JACC. Cardiovascular imaging (2020)
Insights Into Suicide and Depression
Authors: Ned H. Kalin
Journal: American Journal of Psychiatry (2020)

The suffering, anguish, and psychological trauma that loved ones endure when losing a family member to suicide is devastating, and for most people, unimaginable.As mental health care providers and as a profession, we are dedicated to decreasing suffering and to saving lives by preventing suicide.Although there is no doubt that by effectively treating depression and other major psychiatric disorders, we are frequently successful in reducing suicide, all too often we endure the terrible misfortune of losing one of our own patients to suicide.This serves as a stark reminder of our therapeutic inadequacies when it comes to preventing suicide, especially in our most determined and self-destructive patients.Despite major efforts to understand the factors underlying suicide and the efforts of suicide prevention programs, suicide continues to be a major public health problem, with rates increasing each year.In the United States, suicide is the 10thleading overall cause of death, with more than 48,000 deaths attributed to suicide in 2018.At younger ages, death by suicide moves higher up the leading cause of death list to second place for those 10-34 years of age and to fourth place for those ages 35-54.In the United States, more than 50% of suicides are accomplished with firearms, approximately 60% occur in individuals with mood disorders, and there are an estimated 1.4 million suicide attempts per year (1).This issue of the Journal is focused on the interface between depression and suicide.Here, we bring together original research articles and editorials on the genetic and environmental factors that underlie suicide risk and depression.These papers are complemented by articles focused on the treatment and prevention of depression, as well as an exciting translational report implicating specific molecules that are produced by gut bacteria in mediating depressionlike behaviors.We begin the issue with a review article on suicide, coauthored by Dr. John Mann, a suicide expert from Columbia University, and his colleague Dr. Mina Rizk (2).This overview provides a model for the development of suicidal behavior, reviews brain mechanisms implicated in suicidal risk and behavior, and discusses new strategies for identifying and treating at-risk individuals.Also in this issue, we include two interesting and related commentaries, one by Dr. Richard Summers (3) that discusses the concept of burnout, and the other, by Dr. Alexander Charney and coauthors (4), a call to protect the mental well-being of health care workers who are chronically stressed as they work to care for patients fighting to survive COVID-19.
Survival and Outcomes After Noncompletion of Treatment for Anal Cancer
Authors: Richard Garfinkle, Laurent Azoulay, Marylise Boutros
Journal: JAMA Oncology (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal