tbuckley/cabot-search huggingface dataset:
Exhaled nitric oxide in stable adult cystic fibrosis patients, during exacerbation and following CFTR-modifying treatment
Authors: Stefanie Vincken, Sylvia Verbanck, Elke De Wachter, Eef Vanderhelst
Journal: European Respiratory Journal (2019)

<b><i>F</i></b><sub><b>eNO</b></sub><b>is low in stable adult patients with CF, and lower in patients colonised with <i>P. aeruginosa</i>. <i>F</i></b><sub><b>eNO</b></sub><b>cannot be used as a noninvasive marker of CFTR function, since prolonged follow-up showed only a transient rise in <i>F</i></b><sub><b>eNO</b></sub><b>after starting ivacaftor.</b>http://ow.ly/PtfC30ojYFc
IMPACT OF GENDER IN HIGH BLEEDING RISK PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION WITH XIENCE EVEROLIMUS ELUTING STENT: A PATIENT-LEVEL POOLED ANALYSIS FROM FOUR XIENCE POST-APPROVAL TRIALS
Authors: Rishi Chandiramani, Paul Guedeney, Bimmer Claessen, Marco Valgimigli, Roxana Mehran
Journal: Journal of the American College of Cardiology (2019)
Inconsistencies in Reporting Studies of Lactic Acidosis
Authors: Frank de Vries
Journal: JAMA Internal Medicine (2019)

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IMPACT OF TRICUSPID DISEASE IN PATIENTS WITH CONGESTIVE HEART FAILURE AND MITRAL VALVE DISEASE: A NATIONWIDE COHORT STUDY
Authors: Amer N. Kadri, Rama Dilip Gajulapalli, Yasser Sammour, Johnny Chahine, Leen Nusairat, Mohamed Gad, Yasser Al-Khadra, Adrian Hernandez, Serge Harb, Samir Kapadia
Journal: Journal of the American College of Cardiology (2019)
SEX-SPECIFIC DETERMINANTS OF OUTCOMES FOLLOWING TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Michele Pighi, Nicolo Piazza, Giuseppe Martucci, Kevin Lachapelle, Louis Perrault, Anita Asgar, Sandra Lauck, John Webb, Jeffrey Popma, Dae Hyun Kim, Thierry Lefevre, Marino Labinaz, Andre Lamy, Mark Peterson, Rakesh Arora, Nicolas Noiseux, Amanda Trnkus, Jonathan Afilalo
Journal: Journal of the American College of Cardiology (2019)
Abstract 355: A Systematic Review of Medication Adherence Interventions for Heart Failure Patients
Authors: Lila de Tantillo, Juan M Gonzalez, Johis Ortega
Journal: Circulation Research (2018)

Background: Heart failure (HF) is a leading cause of death in the United States and the world. Patients experience substantially reduced longevity and quality of life. Although treatments are available to slow disease progression, medication adherence is necessary. Previous research has explored interventions to increase adherence for HF patients, yet barriers to medication adherence remain. Objective: This systematic review examined articles describing adherence interventions among HF patients. The World Health Organization’s model of Adherence to Long-Term Therapies, developed with patients with chronic illnesses, was used as a conceptual framework. The model describes barriers to adherence as grouped into five factors: patient factors , therapy-related factors , condition-related factors , social/economic factors , and health care/system factors . Methods: A search was conducted in databases CINAHL, PubMed and Scopus to identify interventional studies comprised exclusively of patients diagnosed with HF and their families. Inclusion criteria for articles were evaluation and reporting of adherence as an outcome. Interventions were then considered in context of the WHO factor or factors addressed. Results: This review identified 24 articles meeting inclusion criteria. Of these, all 24 addressed patient factors , 17 discussed therapy-related factors , 11 addressed condition-related factors , 15 addressed social/economic factors , and 15 addressed healthcare/system factors . Discussion: Every intervention in the review examined patient factors of beliefs and behaviors. However, no intervention considered the therapy-related factor of the immediacy of benefit. Among condition-related factors , none of the interventions addressed the role of fatigue. The limited examination of the relationship of race and ethnicity ( social/economic factors ) on adherence was surprising, as previous research has linked these factors to adherence. Conclusions: Categorizing adherence interventions by WHO factors is useful to evaluate the scope of previous research. More work is needed to identify how therapy-related , condition-related and social/economic factors among HF patients can be incorporated into future adherence interventions.
Abstract 288: Circular RNA CircFNDC3b Modulates Cardiac Repair After Myocardial Infarction via FUS-1/VEGF-A Axis
Authors: Venkata N Garikipati, Suresh K Verma, Zhongjian Cheng, Dongming Liang, May M Truongcao, Maria Cimini, Chunlin Wang, Cindy Benedict, Jessica Ibetti, Laurel Grisanti, Sarah M Schumacher, Erhe Gao, Sudarsan Rajan, Jeremy E Wilusz, David Goukassian, Steven Houser, Walter J Koch, Raj Kishore
Journal: Circulation Research (2018)

Circular RNA (circRNA) is a new addition to the list of growing body of non-coding RNAs.Recent studies highlighted that circRNA are dysregulated in cardiovascular disease. However,knowledge of the role of circRNAs in ischemic cardiac injury is limited. Using global circRNAexpression profiling, we identified several circRNA transcripts that were differentially regulatedpost-MI in mice, including circFNDC3b (derived from 2 and 3 exons of cognate FNDC3b gene)which is significantly down regulated. Cell fractionation experiments revealed that circFNDC3bis highly enriched in endothelial cells of post-MI mice. Notably, we found a circFNDC3b orthologin humans, which was also significantly down regulated in ischemic cardiomyopathy patients.Further, gene profile analysis of circFNDC3b overexpression in cardiac endothelial cellsdemonstrated an increase in angiogenic genes. Among them, vascular endothelial growthfactor-A (VEGF-A) was significantly elevated concomitant with reduced in vitro apoptosis ofcardiomyoblasts and endothelial cells, which also exhibited enhanced tube formation. Forcardiac overexpression of circFNDC3b, we generated AAV9 viral particles and found that in vivoover expression attenuated LV dysfunction post-MI and enhanced neovascularization.Mechanistically, circFNDC3b interacts with its potential target RNA binding protein FUS-1 (fusedin sarcoma) and regulate VEGF signaling, thereby reducing cardiomyocyte apoptosis andenhancing neovascularization and cardiac function post-MI. These results indicatethat circFNDC3b is a novel potential target to prevent cardiac remodeling and highlight theimportance of circRNAs in cardiovascular diseases.
THE PARADOX OF CHOICE: THERAPEUTIC DECISION MAKING WITH COMPLEX PULMONARY EMBOLI
Authors: Stephen Morris, Yevgeniy Brailovsky, Amir Darki, Jeremiah Haines, Dalila Masic, Erin Mancl, Kateria Porcaro, Demetrios Doukas, Jason Frazier, Anthony Perez-Tamayo, Bruce Lewis, Jawed Fareed, Verghese Mathew
Journal: Journal of the American College of Cardiology (2019)
Treatment of primary Sjögren’s syndrome with ianalumab (VAY736) targeting B cells by BAFF receptor blockade coupled with enhanced, antibody-dependent cellular cytotoxicity
Authors: Thomas Dörner, Maximilian Georg Posch, Yue Li, Olivier Petricoul, Maciej Cabanski, Julie Marie Milojevic, Esther Kamphausen, Marie-Anne Valentin, Claudia Simonett, Louise Mooney, Andreas Hüser, Hermann Gram, Frank Dietrich Wagner, Stephen John Oliver
Journal: Annals of the Rheumatic Diseases (2019)

Objectives To evaluate the efficacy and safety of ianalumab (VAY736), a B cell-depleting, B cell activating factor receptor-blocking, monoclonal antibody, in patients with active primary Sjögren’s syndrome (pSS) in a double-blind, placebo-controlled, phase II, single-centre study. Methods Patients with pSS, EULAR Sjögren’s Syndrome Disease Activity Index (ESSDAI) ≥6, were randomised to ianalumab single infusion at either 3 mg/kg (n=6), 10 mg/kg (n=12) or placebo (n=9). Outcomes were measured blinded at baseline and weeks 6, 12, 24, and unblinded at end of study (EoS) when B cell numbers had recovered. Clinical outcomes included ESSDAI, EULAR Sjögren’s Syndrome Patient Reported Index (ESSPRI), salivary flow rate, ocular staining score, physician global assessment and patient assessments of fatigue and general quality of life. Laboratory-based measures included circulating leucocyte subsets and markers of B cell activity. Results A similar trend showing positive therapeutic effect by ianalumab was observed across the primary clinical outcome (ESSDAI) and all secondary clinical outcomes (ESSPRI, Multidimensional Fatigue Inventory, Short Form-36, global assessments by physician and patient) versus the placebo-treated group. Rapid and profound B cell depletion of long-lasting duration occurred after a single infusion of ianalumab at either dose. Serum Ig light chains decreased, with return to baseline levels at EoS. Changes in some clinical outcomes persisted through to EoS in the higher dose group. Adverse effects were largely limited to mild to moderate infusion reactions within 24 hours of ianalumab administration. Conclusions Overall results in this single-dose study suggest potent and sustained B cell depletion by ianalumab could provide therapeutic benefits in patients with pSS without major side effects.
NATIONWIDE TRENDS IN COMPLICATIONS OF INFECTIVE ENDOCARDITIS IN UNITED STATES FROM 1999 TO 2014
Authors: Rishi Shrivastav, Dipesh Ludhwani, Kamala Ramya Kallur, Stuthi Perimbeti, Dhrubajyoti Bandyopadhyay, Roberto Carlos Ochoa Jimenez, Eyal Herzog
Journal: Journal of the American College of Cardiology (2019)
ASSOCIATION OF GLYCEMIC VARIABILITY WITH LEFT VENTRICULAR DIASTOLIC FUNCTION IN TYPE 2 DIABETES MELLITUS
Authors: Shun Yokota, Hidekazu Tanaka, Yasuhide Mochizuki, Fumitaka Soga, Kentaro Yamashita, Yusuke Tanaka, Ayu Shono, Makiko Suzuki, Sachiko Yoshikawa, Keiko Sumimoto, Nao Shibata, Jun Mukai, Makiko Suto, Hiroki Takada, Kumiko Dokuni, Keiko Hatazawa, Eriko Hisamatsu, Kensuke Matsumoto, Ken-Ichi Hirata
Journal: Journal of the American College of Cardiology (2019)
ASSOCIATION BETWEEN UNRECOGNIZED MYOCARDIAL INFARCTION AND CEREBRAL INFARCTION
Authors: Tarek Barbar, Oluwayemisi Adejumo, Hediyeh Baradaran, Jiwon Kim, Peter Okin, Monika Safford, Costantino Iadecola, Ajay Gupta, Hooman Kamel, Jonathan Weinsaft, Alexander Merkler
Journal: Journal of the American College of Cardiology (2019)
ATHEROPROTECTIVE ACTIONS OF OXYTOCIN IN HUMAN MACROPHAGES: REDUCED LIPID ACCUMULATION UNDER INFLAMMATORY CONDITIONS
Authors: Ariel Karten, Lora Kasselman, Heather A. Renna, Eric Lam, Daniel S. Glass, Nicholas A. Vernice, Joshua DeLeon, Allison Reiss
Journal: Journal of the American College of Cardiology (2019)
Nlrp3 Inflammasome-Mediated, Il-1 beta-Dependent Inflammatory Responses Drive Severe, Steroid-Insensitive Asthma
Authors: R. Y. Kim, J. W. Pinkerton, A. T. Essilfie, A. A. Robertson, K. J. Baines, J. R. Mayall, M. R. Starkey, P. A. Wark, P. G. Gibson, L. A. O'Neill, M. A. Cooper, J. C. Horvat, P. M. Hansbro
Journal: American Journal of Respiratory and Critical Care Medicine (2016)
Worsening epidemiological situation of carbapenemase-producing Enterobacteriaceae in Europe, assessment by national experts from 37 countries, July 2018
Authors: Alma Brolund, Nina Lagerqvist, Sara Byfors, Marc J Struelens, Dominique L Monnet, Barbara Albiger, Anke Kohlenberg
Journal: Eurosurveillance (2019)

A survey on the epidemiological situation, surveillance and containment activities for carbapenemase-producing Enterobacteriaceae (CPE) was conducted in European countries in 2018. All 37 participating countries reported CPE cases. Since 2015, the epidemiological stage of CPE expansion has increased in 11 countries. Reference laboratory capability, dedicated surveillance and a specific national containment plan are in existence in 33, 27 and 14 countries, respectively. Enhanced control efforts are needed for CPE containment in Europe.
LOW ACHIEVEMENT OF RECOMMENDED LOW-DENSITY LIPOPROTEIN CHOLESTEROL GOALS FOR PRIMARY OR SECONDARY PREVENTION IN PATIENTS ADMITTED WITH SUSPECTED ACUTE CORONARY SYNDROME
Authors: Jose A. Barrabes, Laia Mila, Rosa-Maria Lidon, Antonia Sambola, Jordi Bañeras, Agnes Rafecas Ventosa, David Garcia-Dorado
Journal: Journal of the American College of Cardiology (2019)
ASSOCIATION OF ANGIOPOIETIN-2 AND ATRIAL FIBRILLATION BURDEN IN CRITICALLY ILL PATIENTS
Authors: Lily Stern, Kathleen Liu, Hanjing Zhuo, Kirsten Kangelaris, Antonio Gomez, Alejandra Jauregui, Kathryn Vessel, Thomas Deiss, Jason Abbott, Ashish Agrawal, Michael Matthay, Carolyn S. Calfee, Liviu Klein
Journal: Journal of the American College of Cardiology (2019)
Abstract 203: Short Telomeres Induce p53 and Autophagy and Modulate Age-Associated Changes in Cardiac Progenitor Cell Fate
Authors: Nirmala Hariharan, Collin Matsumoto, Yan Jiang, Mark Sussman
Journal: Circulation Research (2018)

Aging severely limits myocardial repair and regeneration. Delineating the impact of age-associated factors such as short telomeres is critical to enhance the regenerative potential of cardiac progenitor cells (CPCs). We hypothesized that short telomeres activate p53 and induce autophagy to elicit the age-associated change in CPC fate. We compared mouse strains with different telomere lengths for phenotypic characteristics of aging and also isolated CPCs from them. Wild mouse strain Mus musculus castaneus (CAST) possessing short telomeres exhibits early cardiac aging evidenced as diastolic dysfunction, hypertrophy, fibrosis, and senescence, as compared with common lab strains FVB and C57 bearing longer telomeres. CAST CPCs with short telomeres demonstrate altered cell fate as characterized by cell cycle arrest, senescence, basal commitment, and loss of quiescence. Consistent findings of altered cell fate are also evident in old CPCs isolated from aged mice and adult human failing heart CPCs with significantly shorter telomeres. Elongation of telomeres using a modified mRNA for telomerase restores youthful properties to CAST CPCs, evidenced as increased proliferation and quiescence as well as reduced senescence and commitment. Short telomeres induce autophagy in CPCs, a catabolic protein degradation process, as evidenced by reduced p62 and increased accumulation of autophagic puncta. Pharmacological inhibition of autophagosome formation reverses the cell fate to a more youthful phenotype. Mechanistically, cell fate changes induced by short telomeres are partially p53 dependent, as p53 inhibition rescues senescence and commitment observed in CAST CPCs, coincident with attenuation of autophagy. In conclusion, short telomeres activate p53 and autophagy to tip the equilibrium away from quiescence and proliferation toward differentiation and senescence, leading to exhaustion of CPCs. This study provides the mechanistic basis underlying age-associated cell fate changes that will enable identification of molecular strategies to prevent senescence of CPCs.
Abstract 452: Alpha-Ketoglutarate Dehydrogenase Inhibition by the Oncometabolite D2-HG Causes Proteome and Metabolome Remodeling in Myocytes
Authors: Anja Karlstaedt, Heidi Vitrac, Koen Raedschelders, Weston R Spivia, Daniel M, Radhika Khanna, Jennifer VanEyk, Heinrich Taegtmeyer
Journal: Circulation Research (2018)

Autophagy “scavenges” proteins and yields amino acids under conditions of metabolic stress to support cell survival and growth. In isocitrate dehydrogenase 1 and 2 mutant tumors, increased plasma levels of the oncometabolite D-2-hydroxyglutarate (D2-HG) are associated with systemic effects, including dilated cardiomyopathy. Our recent in vivo work showed that increased D2-HG supply by IDH2-mutant hematopoetic stem cells causes heart and skeletal muscle atrophy, and decreases cellular ATP and NADH. While heart failure in cancer is commonly associated with chemotherapy, cancer survivors have a five-fold increased risk of heart failure independent of any cytostatic treatment. The connection between metabolic changes and proteomic remodeling in this context remain poorly understood. We hypothesize that D2-HG-mediated alpha-ketoglutarate dehydrogenase inhibition in myocytes results in metabolomic pertubations, proteomic remodeling, and increased autophagy. We measured autophagic flux and remodeling of the stable proteome upon D2-HG treatment in vivo using wild-type C57BL/J6 mice, and in vitro using both cultured L6 myocytes and adult mouse ventricular cardiomyocytes. We observed increases in the LC3-II/LC3-I ratio and p62 expression in heart and skeletal muscle from mice treated with D2-HG, indicating activation of autophagy. Live cell imaging with GFP-tagged LC3 indicated that D2-HG (1 mM) increased LC3-II lipidation and flux within 24 h. Furthermore, we observed increased phosphorylation and activation of AMPK, while phosphorylation of mTOR and p70S6K were decreased in presence of D2-HG. In vitro exposure to D2-HG resulted in the formation of a molecular complex between Sirt1 and LC3, indicating that increased NAD+ in presence of D2-HG promotes Sirt1 activation in myocytes. Finally, we used LC-MS/MS to assess the effect of D2-HG on the stable proteome and metabolome in heart and skeletal muscle. Myocytes exposed to D2-HG showed proteomic remodeling and metabolomic changes within 24 h. Integrating multi-omics data in a network-level context revealed upregulation of glycolysis and the pentose phosphate pathway. In short, autophagy activation may support proteome remodeling in muscle cells during IDH-mutant leukemia.
CARDIAC TAMPONADE SECONDARY TO A NOVEL MICRA LEADLESS PACEMAKER
Authors: Andrew J. Chapel, Firehiwot Achamyeleh, Chau Vu, Chukwunweike Nwosu, Joseph Hellman, Atul Bali, Gary Ledley, Sung-Hae Cho
Journal: Journal of the American College of Cardiology (2019)
THE IMPACT OF HEMODYNAMICALLY SIGNIFICANT MITRAL REGURGITATION ON LEFT ATRIAL DYNAMICS IN PATIENTS HOSPITALIZED FOR ACUTE DECOMPENSATED HEART FAILURE
Authors: Maurizio Losito, Andrea Giammaresi, Valentina Labate, Maria Michela Caracciolo, Francesco Bandera, Marina Rovida, Giacomo D'Alesio, Alessandro Vella, Francesca Bevilacqua, Monica Barki, Eleonora Alfonzetti, Marco Guazzi
Journal: Journal of the American College of Cardiology (2019)
Letter by El-Battrawy et al Regarding Article, “Clinical Presentation and Outcome in a Contemporary Cohort of Patients With Acute Myocarditis”
Authors: Ibrahim El-Battrawy, Martin Borggrefe, Ibrahim Akin
Journal: Circulation (2019)

The article by Ammirati et al 1 published in in Circulation describing the in-hospital management and long-term outcome of patients with acute myocarditis elicited great interest among members of our research group.The final study population derived from a retrospective multicenter registry of 19 hospitals included 443 patients with acute myocarditis, diagnosed after elevated troponin levels corresponded to signs of edema with late gadolinium enhancement on cardiac magnetic resonance imaging or after results from an endomyocardial biopsy.Both these procedures, however, were not performed consecutively in the study patients.It is interesting to note that Takotsubo syndrome, 2 as defined by the Mayo Clinic criteria, suggests that patients could share a similar clinical, biochemical, and morphological presentation as myocarditis.A detailed cardiac magnetic resonance imaging study performed on the patient with Takotsubo syndrome during the index event demonstrated significant inflammation and edema, essentially mimicking the results of patients with myocarditis. 3In addition, the list of adverse cardiac events occurring in patients with Takotsubo syndrome, such as life-threatening arrhythmias, cardiogenic shock, reduced ejection fraction, and mortality, are similar to those occurring in the patient with acute myocarditis. 4,5onsidering that cardiac magnetic resonance imaging and endomyocardial biopsy were not performed routinely in all the included patients, it could be possible that some of these patients could just as well have had Takotsubo syndrome.In this scenario, a bias in results has to be considered while factoring in the differences in patients presenting with either an impaired or a preserved left ventricular ejection.
HIV POST SCD: RATES OF AUTOPSY-DEFINED SUDDEN ARRHYTHMIC DEATH AND CARDIAC FIBROSIS ARE &gt;60% HIGHER IN PERSONS WITH HIV
Authors: Zian H. Tseng, Ellen Moffatt, Annie Bedigian, Joseph K. Wong, Eric Vittinghoff, Andrew Connolly, Jeffrey E. Olgin, Priscilla Hsue
Journal: Journal of the American College of Cardiology (2019)
VARIABILITY OF PRACTICE AND RISK FOR ADVANCED DIAGNOSTIC MODALITIES PRIOR TO SUPERIOR CAVOPULMONARY CONNECTION AS PART OF STAGED SINGLE VENTRICLE PALLIATION: A MULTI-INSTITUTION STUDY
Authors: Ari Gartenberg, Andrew Glatz, Aimee Armstrong, Susan Casey, Miranda Kunz, Dawn Witt, Katelyn Storey, Cynthia Rigsby, B. Kelly Han
Journal: Journal of the American College of Cardiology (2019)
THE IMPORTANCE OF SPONTANEOUS CORONARY ARTERY DISSECTION (SCAD) SPECIFIC CARE IN REDUCING RECURRENT EVENTS
Authors: Francesca Ponzini, Shelly Mishra, Shilpa Sharma, Jessica Duran, Yousef Ghazzawi, Mark Lindsay, Nandita S. Scott, Sarah Tsiaras, Aferdita Spahillari, Malissa Jane Wood
Journal: Journal of the American College of Cardiology (2019)
VA-ECMO AS A BRIDGE TO GUIDELINE-DIRECTED MEDICAL THERAPY FOR PATIENTS WITH CHRONIC HEART FAILURE PRESENTING WITH CARDIOGENIC SHOCK: AN EFFECTIVE ALTERNATIVE TO PALLIATIVE CARE WHEN ADVANCE THERAPIES ARE NOT POSSIBLE
Authors: Leonardo Salazar, Celia Aguilar, Antonio Figueredo, Maria Rodriguez Gonzalez, Camilo Pizarro, Luis Echeverria Correa, Carlos Alviar
Journal: Journal of the American College of Cardiology (2019)