tbuckley/cabot-search huggingface dataset:
OP0175 METHOTREXATE IN PATIENTS WITH HAND OSTEOARTHRITIS REFRACTORY TO ANALGESICS: A RANDOMISED, DOUBLE-BLIND, PLACEBO CONTROLLED TRIAL
Authors: Stéphanie Ferrero, Ruth Wittoek, Edem Allado, Eric Fontas, Coralie Cruzel, Liana Euller-Ziegler, Damien Loeuille, Christian Roux
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> To date, no studies have been published on the effect of Methotrexate (MTX) in hand osteoarthritis (HOA). <h3>Objectives</h3> The aim of our study is to examine the effect of methotrexate on pain in symptomatic erosive HOA, as well as its functional and structural effect using MRI and radiography. <h3>Methods</h3> This prospective, single-center, randomized, double-blind, placebo-controlled study followed patients with HOA over 12 months. Patients were randomized to Methotrexate 10 mg per week or placebo. The primary endpoint was pain assessment at 3 months, and secondary endpoints were clinical (Visual Analogue Scale "VAS" pain at 12 months), and radiographic (radiographic anatomical score, then the Ghent University Score System "GUSS" and MRI). All subjects aged between 45 and 85 years, who had apparent NSAIDs and pain traitement failure with an VAS greater than 4/10, and at least one erosive joint were included. <h3>Results</h3> Out of 71 evalued patients with symptomatic erosive HOA, and 64 matched the inclusion criteria and were randomized. Among them, 32 patients were randomized in the placebo group and 32 in the Methotrexate group. There was no significant difference between the two groups on the primary endpoint at 3 months, with an average decrease in VAS in the placebo group of 8.36 mm (+/- 25.15), and 17.47 mm (+/- 28.37) in the treatment group (p = 0.1797). At 12 months, no difference was found in the evolution of pain between the two groups (p = 0.6045) as well as in the functional evolution. In subjects taking Methotrexate, erosive joints move more to a remodeling phase undergoing treatment (27%) than placebo subjects (15%) (p = 0.0278). They also seem to evolve less towards erosion when their joints present a space loss (29% become erosive under placebo, against 8% in the Methotrexate group) (p = 0.0879). No predictor of erosive outcome was found in patients with non-erosive hand osteoarthritis. <h3>Conclusion</h3> Our study does not show superior efficacy of MTX over placebo over pain and function in subjects with erosive HOA. Our results suggest a possible structural effect on the radiological evolution of HOA under Methotrexate. <h3>Disclosure of Interests</h3> None declared
NSCLC患者のエルロチニブ誘発皮膚紅斑治療におけるBANXIA XIEXIN処方のランダム化比較臨床試験評価 | 文献情報 | J-GLOBAL 科学技術総合リンクセンター
Authors: L Sima
Journal: Annals of Oncology (2009)
Contemporary Application of Cardiovascular Magnetic Resonance Imaging
Authors: Yuchi Han, Yucheng Chen, Victor A. Ferrari
Journal: Annual Review of Medicine (2020)

Cardiovascular magnetic resonance imaging (CMR) is a comprehensive and versatile diagnostic and prognostic imaging modality that plays an increasingly important role in management of patients with cardiovascular disease. In this review, we discuss CMR applications in nonischemic cardiomyopathy, ischemic heart disease, arrhythmias, right ventricular diseases, and valvular heart disease. We emphasize the quantitative nature of CMR in current practice, from volumes, function, myocardial strain analysis, and late gadolinium enhancement to parametric mapping, including T1, T2, and T2* relaxation times and extracellular volume fraction assessment.
Addressing the Perceived Duality of Represented and Unrepresented Patients: Legal Findings in a Moral Context
Authors: Beau P. Sperry, Erin S. DeMartino, Paul S. Mueller
Journal: The American Journal of Bioethics (2020)

"Addressing the Perceived Duality of Represented and Unrepresented Patients: Legal Findings in a Moral Context." The American Journal of Bioethics, 20(2), pp. 49–50
GPs are risking own health to provide millions of extra appointments, BMA warns
Authors: Elisabeth Mahase
Journal: BMJ (2020)

The latest NHS appointment data show that GPs in England are “risking their own health and wellbeing” as they try to cope with the “intense strain” that practices are under, the BMA’s General Practitioners Committee has warned.

The figures, released by NHS Digital on 31 January, showed that general practices in England provided 312 …
Advances in the diagnosis and treatment of dry eye
Authors: Takashi Kojima, Murat Dogru, Motoko Kawashima, Shigeru Nakamura, Kazuo Tsubota
Journal: Progress in Retinal and Eye Research (2020)

The core mechanism of dry eye is the tear film instability. Tear film-oriented diagnosis (TFOD) is a concept to clarify the cause of tear film instability by tear film, and tear film-oriented treatment (TFOT) is a concept to treat dry eye disease by replacing the lacking components of the tear film layer based on the TFOD. In TFOD, the fluorescein breakup pattern of the tear film is important, and the subtype of dry eye can be judged to some extent from the breakup patterns. Current noninvasive devices related to the dynamic analysis of the tear film and visual acuity enabled the diagnosis of dry eye, subtype analysis, and the extent of severity. In Asian countries, secretagogues represent the main treatment in TFOT. Since meibomian gland dysfunction is a factor that greatly affects the tear breakup time, its treatment is also essential in the dry eye treatment strategy. A newly discovered dry eye subtype is the short breakup time-type (BUT) of dry eye. The only abnormal finding in this disease is the short BUT, suggesting a relationship with ocular neuropathic pain and eye strain. Recently, data from many studies have accumulated which show that dry eye is a life-style disease. In addition to the treatment of dry eyes, it is becoming possible to prevent the onset by intervening with the daily habits, diet, exercise and sleep, etc. It has been pointed out that oxidative stress is also involved in the pathology of dry eye, and intervention is being carried out by improving diet and taking supplements. Future research will be needed to link clinical findings to the molecular biological findings in the tear film.
Regulatory T Cell Development
Authors: Peter A. Savage, David E.J. Klawon, Christine H. Miller
Journal: Annual Review of Immunology (2020)

Foxp3-expressing CD4 + regulatory T (Treg) cells play key roles in the prevention of autoimmunity and the maintenance of immune homeostasis and represent a major barrier to the induction of robust antitumor immune responses. Thus, a clear understanding of the mechanisms coordinating Treg cell differentiation is crucial for understanding numerous facets of health and disease and for developing approaches to modulate Treg cells for clinical benefit. Here, we discuss current knowledge of the signals that coordinate Treg cell development, the antigen-presenting cell types that direct Treg cell selection, and the nature of endogenous Treg cell ligands, focusing on evidence from studies in mice. We also highlight recent advances in this area and identify key unanswered questions.
35P Adjuvant Chemotherapy in Node-Negative (N0) Breast Cancer: Routine Upa/Pai-1 Determination
Authors: N. Tubiana-Mathieu, V. Fermeaux, N. Saïdi, J. Monteil, J. Mollard, Y. Aubard, I. Jammet, L. Venat-Bouvet
Journal: Annals of Oncology (2012)
Self-activated <i>in vivo</i> therapeutic cascade of erythrocyte membrane-cloaked iron-mineralized enzymes
Authors: Wen Liu, Miao-Liang Ruan, Lamei Liu, Xin Ji, Yandong Ma, Pengfei Yuan, Guoheng Tang, Hongsheng Lin, Jian Dai, Wei Xue
Journal: Theranostics (2020)

Biomineralization of enzymes for in vivo diagnosis and treatment of diseases remain a considerable challenge, due to their severe reaction conditions and complicated physiological environment. Herein, we reported a biomimetic enzyme cascade delivery nanosystem, tumor-targeted erythrocyte membrane (EM)-cloaked iron-mineralized glucose oxidases (GOx-Fe0@EM-A) for enhancing anticancer efficacy by self-activated in vivo cascade to generate sufficient high toxic •OH at tumor site. Methods: An ultra-small Fe0 nanoparticle (Fe0NP) was anchored in the inner cavity of glucose oxidase (GOx) to form iron-mineralized glucose oxidase (GOx-Fe0) as a potential tumor therapeutic nanocatalyst. Moreover, erythrocyte membrane cloaking delivery of GOx-Fe0in vivo was designed to effectively accumulate ultra-small GOx-Fe0 at tumor site. Results: GOx-Fe0@EM-A had satisfactory biocompatibility and light-trigged release efficiency. Erythrocyte membrane cloaking of GOx-Fe0@EM-A not only prolongs blood circulation but also protects in vivo enzyme activity of GOx-Fe0; Tumor targeting of GOx-Fe0@EM-A endowed preferential accumulation at tumor site. After NIR light irradiation at tumor site, erythrocyte membrane of GOx-Fe0@EM-A was ruptured to achieve light-driven release and tumor deep penetration of ultra-small nanosize GOx-Fe0 by the photothermal effect of ICG. Then, GOx-Fe0 occurred self-activated in vivo cascade to effectively eradicate tumor by producing the highly cumulative and deeply penetrating •OH at tumor site. Conclusion: Tumor-targeted erythrocyte membrane-cloaked iron-mineralized glucose oxidase (GOx-Fe0@EM-A) exhibits a promising strategy for striking antitumor efficacy by light-driven tumor deep penetration and self-activated therapeutic cascade.
Rational design of caspase-responsive smart molecular probe for positron emission tomography imaging of drug-induced apoptosis
Authors: Ling Qiu, Wei Wang, Ke Li, Ying Peng, Gaochao Lv, Qingzhu Liu, Feng Gao, Yann Seimbille, Minhao Xie, Jianguo Lin
Journal: Theranostics (2019)

Glioblastoma is one of the most common primary tumor types of central nervous system (CNS) with high malignance and lethality.Although many treatment options are currently available, the therapy of brain cancers remains challenging because of blood-brain-barrier (BBB) which prevents most of the chemotherapeutics into the CNS.In this work, a poly(amidoamine) dendrimer-based carrier was fabricated and modified with angiopep-2 (Ang2) peptide that has been demonstrated to bind to low density lipoprotein receptor-relative protein-1 (LRP1) on the endothelial cells of BBB and could therefore induce BBB penetration of the carrier.To improve tumor-targeting effect towards the glioma sites, the dendrimer was simultaneously functionalized with an epidermal growth factor receptor (EGFR)-targeting peptide (EP-1) which was screened from a "one-bead one-compound" (OBOC) combinatorial library.EP-1 peptide was demonstrated to have high affinity and specificity to EGFR at both the molecular and cellular levels.The dual-targeting dendrimer exhibited outstanding BBB penetrability and glioma targeting efficiency both in vitro and in vivo, which strikingly enhanced the anti-gliomas effect of the drugs and prolonged the survival of gliomas-bearing mice.These results show the potential of the dual-targeting dendrimer-based carrier in the therapy of gliomas through enhancing BBB penetrability and tumor targeting.
Opportunities and challenges in using real-world data for health care
Authors: Vivek A. Rudrapatna, Atul J. Butte
Journal: Journal of Clinical Investigation (2020)

Real-world data (RWD) continue to emerge as a new source of clinical evidence. Although the best-known use case of RWD has been in drug regulation, RWD are being generated and used by many other parties, including biopharmaceutical companies, payors, clinical researchers, providers, and patients. In this Review, we describe 21 potential uses for RWD across the spectrum of health care. We also discuss important challenges and limitations relevant to the translation of these data into evidence.
China coronavirus: partial border closures into Hong Kong are not enough, say doctors
Authors: Jane Parry
Journal: BMJ (2020)

As the novel coronavirus (2019-nCOV) outbreak rapidly expands across the border in mainland China, healthcare workers in Hong Kong are bracing for a potential explosion of cases locally and have urged the government to severely restrict arrivals from mainland China or even to close the border completely.

Eight cases were confirmed in Hong Kong as of 27 January, and 38% of the 663 beds in the negative pressure wards, which are used to isolate patients at public hospitals, were already in use, said officials. They expressed concern that the public health system might be overwhelmed if a local “super-spreader” event occurs or by people from mainland China coming into Hong Kong to seek treatment.

On 28 January Carrie Lam, Hong Kong chief executive, announced a partial border closure, halting all cross border rail routes from midnight on 30 January, as well as a suspension of six border checkpoints, suspension of ferries, gradual reduction of cross border flights from 480 a week to 240 until further notice, and a reduction of cross …
Last Call to Wisdom
Authors: Ronald V. Loge
Journal: Annals of Internal Medicine (2020)

On Being a Doctor4 February 2020Last Call to WisdomRonald V. Loge, MDRonald V. Loge, MDDillon, Montana (R.V.L.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M19-2664 Audio Reading - “Last Call to Wisdom” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “Last Call to Wisdom” by Ronald V. Loge, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail It is early afternoon. I am halfway to Wisdom. Today's journey began 25 miles back at my office after I completed my final patient visits. However, it really started nearly four decades ago when I arrived in southwestern Montana, green but eager to establish a practice as my community's first internist. Today, I am making my last house call and closing my career as a rural physician.After I summit Big Hole Pass, the halfway point, stunning views of the valley spread before me. Sunlight and patchy blue sky break through the snow squalls of the Beaverhead Range to the ... Author, Article, and Disclosure InformationAffiliations: Dillon, Montana (R.V.L.)Corresponding Author: Ronald V. Loge, MD, 615 S. Pacific Street, Dillon, MT 59725; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement Audio Reading - “Last Call to Wisdom” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “Last Call to Wisdom” by Ronald V. Loge, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 4 February 2020Volume 172, Issue 3Page: 218-219KeywordsFallsHeart rateParkinson diseaseRiversShouldersSocial welfareSpineTongueWeaningWheelchairs ePublished: 4 February 2020 Issue Published: 4 February 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Self-tests Increased HIV Diagnoses
Authors: Anita Slomski
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of Netherton Syndrome With Dupilumab
Authors: Alexa B. Steuer, David E. Cohen
Journal: JAMA Dermatology (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Molecular characteristics of carbapenemase-producing Enterobacterales in the Netherlands; results of the 2014–2018 national laboratory surveillance
Authors: K. van der Zwaluw, S. Witteveen, L. Wielders, M. van Santen, F. Landman, A. de Haan, L.M. Schouls, T. Bosch, J.W.T. Cohen Stuart, D.C. Melles, K. van Dijk, C.E. Visser, D.W. Notermans, M.L. van Ogtrop, B.F.M. Werdmuller, B.C. van Hees, J.A.J.W. Kluytmans, W. van den Bijllaardt, E.M. Kraan, M.P.M. van der Linden, E.E. Mattsson, F.W. Sebens, E. de Jong, H.M.E. Frénay, B. Maraha, A.J. van Griethuysen, G.J. van Asselt, A. Demeulemeester, B.B. Wintermans, M. van Trijp, A. Ott, E. Bathoorn, M. Lokate, J.C. Sinnige, E.I.G.B. de Brauwer, F.S. Stals, W. Silvis, L.J. Bakker, J.W. Dorigo-Zetsma, B. Ridwan, K. Waar, A.T. Bernards, S.P. van Mens, N. Roescher, M.H. Nabuurs-Franssen, H. Wertheim, T. Schülin, B.M.W. Diederen, L. Bode, M. van Rijn, S. Dinant, O. Pontesilli, P. de Man, M.A. Leversteijn-van Hall, E.P.M. van Elzakker, A.E. Muller, N.H. Renders, D.W. van Dam, A.G.M. Buiting, A.L.M. Vlek, A. Reuland, F.N.J. Frakking, I.T.M.A. Overdevest, R.W. Bosboom, T.A.M. Trienekens, M.J. Bruins, M.J.H.M. Wolfhagen
Journal: Clinical Microbiology and Infection (2020)

ObjectivesCarbapenem resistance mediated by mobile genetic elements has emerged worldwide and has become a major public health threat. To gain insight into the molecular epidemiology of carbapenem resistance in The Netherlands, Dutch medical microbiology laboratories are requested to submit suspected carbapenemase-producing Enterobacterales (CPE) to the National Institute for Public Health and the Environment as part of a national surveillance system.MethodsMeropenem MICs and species identification were confirmed by E-test and MALDI-TOF and carbapenemase production was assessed by the Carbapenem Inactivation Method. Of all submitted CPE, one species/carbapenemase gene combination per person per year was subjected to next-generation sequencing (NGS).ResultsIn total, 1838 unique isolates were received between 2014 and 2018, of which 892 were unique CPE isolates with NGS data available. The predominant CPE species were Klebsiella pneumoniae (n = 388, 43%), Escherichia coli (n = 264, 30%) and Enterobacter cloacae complex (n = 116, 13%). Various carbapenemase alleles of the same carbapenemase gene resulted in different susceptibilities to meropenem and this effect varied between species. Analyses of NGS data showed variation of prevalence of carbapenemase alleles over time with blaOXA-48 being predominant (38%, 336/892), followed by blaNDM-1 (16%, 145/892). For the first time in the Netherlands, blaOXA-181, blaOXA-232 and blaVIM-4 were detected. The genetic background of K. pneumoniae and E. coli isolates was highly diverse.ConclusionsThe CPE population in the Netherlands is diverse, suggesting multiple introductions. The predominant carbapenemase alleles are blaOXA-48 and blaNDM-1. There was a clear association between species, carbapenemase allele and susceptibility to meropenem.
Phase II Study of Erlotinib in Japanese Patients with Pretreated EGFR Mutation Positive Non-Small Cell Lung Cancer: Lung Oncology Group in Kyushu, Japan (LOGIK0803)
Authors: K. Takayama, Y. Nakanishi, S. Kawakami, K. Saruwatari, K. Yamada, R. Morinaga, N. Aragane, S. Nagata, J. Kishimoto, Y. Ichinose
Journal: Annals of Oncology (2012)
UK offers fast track visas to top researchers and scientists
Authors: Ingrid Torjesen
Journal: BMJ (2020)

An expanded visa scheme to make it easier for leading researchers and scientists to work in the UK after Brexit will launch on 20 February, the Home Office has announced.

The Global Talent entry route, first announced by the government last August,1 will replace the existing Tier 1 Exceptional Talent route, effectively expanding it with a few key changes.

The Exceptional Talent route was set up to enable recognised leaders in certain sectors and people with exceptional promise to work in the UK. The relevant areas range from science and technology, through engineering and architecture, to fashion, film, and television.

Unlike the Exceptional Talent route, which caps the number of visas that …
Whole Abdominopelvic Radiotherapy (WAPRT) Using Intensity Modulated Arc Therapy (IMAT) as Palliation for Platinum-Resistant Ovarian Cancer
Authors: A.P. Makar, K. Vandecasteele, P. Tummers, P. Ost, L. Delrue, S. Van Belle, R. Van den Broecke, V. Fonteyne, W. De Never, G. De Meerleer
Journal: Annals of Oncology (2012)
Syndromic Surveillance of Suicidal Ideation and Self-Directed Violence — United States, January 2017–December 2018
Authors: Marissa L. Zwald, Kristin M. Holland, Francis B. Annor, Aaron Kite-Powell, Steven A. Sumner, Daniel A. Bowen, Alana M. Vivolo-Kantor, Deborah M. Stone, Alex E. Crosby
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

Suicide is a growing public health problem in the United States, claiming approximately 47,000 lives in 2017 (1). However, deaths from suicide represent only a small part of a larger problem because each year millions of persons experience suicidal ideation and engage in suicidal and nonsuicidal self-directed violence, both risk factors for suicide (2). Emergency departments (EDs) are an important setting for monitoring these events in near real time (3-5). From 2001 to 2016, ED visit rates for nonfatal self-harm increased 42% among persons aged ≥10 years (1). Using data from CDC's National Syndromic Surveillance Program (NSSP), ED visits for suicidal ideation, self-directed violence, or both among persons aged ≥10 years during January 2017-December 2018 were examined by sex, age group, and U.S. region. During the 24-month period, the rate of ED visits for suicidal ideation, self-directed violence, or both increased 25.5% overall, with an average increase of 1.2% per month. Suicide prevention requires comprehensive and multisectoral approaches to addressing risk at personal, relationship, community, and societal levels. ED syndromic surveillance data can provide timely trend information and can support more targeted and prompt public health investigation and response. CDC's Preventing Suicide: A Technical Package of Policy, Programs, and Practices includes tailored suicide prevention strategies for health care settings (6).