tbuckley/cabot-search huggingface dataset:
Abstract 10250: Associations of Adiponectin and Leptin With Measures of Cardiac Structure and Function Among African Americans: The Jackson Heart Study
Authors: Steven R Horbal, Daniel Dibaba, Solomon K Musani, Michael E Hall, Jiankang Liu, Herman A Taylor, Ervin R Fox, Aurelian Bidulescu
Journal: Circulation (2015)

Introduction: Adipokines are associated with measure of cardiac remodeling. Studies assessing the effects of adipokines among those with and without common risk factors such as hypertension, obesity and type 2 diabetes are sparse. Thus, the objective of our investigation was to assess the association of adiponectin and leptin with measures of myocardial structure and function among African Americans--a group with a high prevalence of cardiovascular risk factors. Methods: The study sample included 4,866 African American participants from the Jackson Heart Study. Multivariable adjusted linear models were used to determine the association of adiponectin and leptin with echocardiographic measures of myocardial structure and function including left ventricular (LV) mass index, and E/A ratio. Stratified analyses were conducted among participants with and without hypertension, obesity and type 2 diabetes. Results: In participants who were not obese, LV mass index was directly associated with adiponectin and inversely associated with leptin [β = 0.52, β = - 2.03, respectively]. A direct association of adiponectin and an inverse association of leptin with E/A ratio was observed among those who were not obese [β = - 0.02, β = - 0.02, respectively]. A direct association of adiponectin and an inverse association of leptin with E/A ratio were observed regardless of hypertensive status or Type II diabetes status [Overall: β = 0.02, β = - 0.02, respectively]. Conclusion: In a large African American population, opposite associations of adiponectin and leptin were observed with measures of myocardial structure and function that varied based on presence or absence of common cardiovascular risk factors.
A Clinical Appraisal of the Vectorcardiogram in Myocardial Infarction
Authors: PAUL G. HUGENHOLTZ, GERALD H. WHIPPLE, HAROLD D. LEVINE
Journal: Circulation (1961)

A total of 161 vectorcardiograms was recorded with the Grishman cube system in patients with suspected myocardial infarction. In the group of 49 cases subsequently examined post mortem and of 73 non-autopsied cases, in whom the diagnosis of infarction appeared certain, a comparison was made between the standard electrocardiogram and the vectorcardiogram taken in succession. The vectorcardiogram demonstrated more infarcts than the electrocardiogram. Of a total of 122 cases in which the vectorcardiogram showed infarction, 19 had normal and 17 equivocal electrocardiograms. A number of simple and easily applicable criteria for the vectorcardiographic diagnosis of infarction are given. It appears that even the older, uncorrected cubelead system permits a more accurate diagnosis than currently available standard electrocardiographic procedure. It is suggested that this method of exploration may be useful in cases of suspected myocardial infarction in which the routine electrocardiographic examination leaves doubt.
Neuronal deletion of Gtf2i, associated with Williams syndrome, causes behavioral and myelin alterations rescuable by a remyelinating drug
Authors: Boaz Barak, Zicong Zhang, Yuanyuan Liu, Ariel Nir, Sari S. Trangle, Michaela Ennis, Kirsten M. Levandowski, Dongqing Wang, Kathleen Quast, Gabriella L. Boulting, Yi Li, Dashzeveg Bayarsaihan, Zhigang He, Guoping Feng
Journal: Nature Neuroscience (2019)
FRI-233-The impact of community-based rapid point-of-care testing on enhancing uptake of hepatitis C treatment for people who inject drugs in needle and syringe services
Authors: Jessica Howell, Bridget Williams, Alisa Pedrana, Michael Traeger, Joseph Doyle, Ned Latham, Bridget Draper, Chloe Layton, Frances Bramwell, Dean Membrey, Margaret Mcpherson, Janine Roney, Alexander Thompson, Margaret Hellard
Journal: Journal of Hepatology (2019)
An EAACI position paper on the investigation of perioperative immediate hypersensitivity reactions
Authors: Lene Heise Garvey, Didier G. Ebo, Paul‐Michel Mertes, Pascale Dewachter, Tomaz Garcez, Peter Kopac, José Julio Laguna, Anca Mirela Chiriac, Ingrid Terreehorst, Susanna Voltolini, Kathrin Scherer
Journal: Allergy (2019)

Perioperative immediate hypersensitivity reactions are rare. Subsequent allergy investigation is complicated by multiple simultaneous drug exposures, the use of drugs with potent effects and the many differential diagnoses to hypersensitivity in the perioperative setting. The approach to the investigation of these complex reactions is not standardized, and it is becoming increasingly apparent that collaboration between experts in the field of allergy/immunology/dermatology and anaesthesiology is needed to provide the best possible care for these patients. The EAACI task force behind this position paper has therefore combined the expertise of allergists, immunologists and anaesthesiologists. The aims of this position paper were to provide recommendations for the investigation of immediate-type perioperative hypersensitivity reactions and to provide practical information that can assist clinicians in planning and carrying out investigations.
The contribution of injection drug use to hepatitis C virus transmission globally, regionally, and at country level: a modelling study
Authors: Adam Trickey, Hannah Fraser, Aaron G Lim, Amy Peacock, Samantha Colledge, Josephine G Walker, Janni Leung, Jason Grebely, Sarah Larney, Natasha K Martin, Matthew Hickman, Louisa Degenhardt, Margaret T May, Peter Vickerman
Journal: The Lancet. Gastroenterology & hepatology (2019)
EmptyDrops: distinguishing cells from empty droplets in droplet-based single-cell RNA sequencing data
Authors: Aaron T. L. Lun, Samantha Riesenfeld, Tallulah Andrews, The Phuong Dao, Tomas Gomes, John C. Marioni
Journal: Genome biology (2019)

Droplet-based single-cell RNA sequencing protocols have dramatically increased the throughput of single-cell transcriptomics studies. A key computational challenge when processing these data is to distinguish libraries for real cells from empty droplets. Here, we describe a new statistical method for calling cells from droplet-based data, based on detecting significant deviations from the expression profile of the ambient solution. Using simulations, we demonstrate that EmptyDrops has greater power than existing approaches while controlling the false discovery rate among detected cells. Our method also retains distinct cell types that would have been discarded by existing methods in several real data sets.
SAT-067-Prospective assessment of sarcopenia as a prognostic factor for survival in patients with liver cirrhosis
Authors: Wolfgang Maximilian Kremer, Sandra Koch, Dorothea Lochner, Anna Christina Koch, Felix Hahn, Annette Grambihler, Christian Labenz, PD Dr. Schattenberg Jorn, Christoph Duber, Peter Robert Galle, Arndt Weinmann, Martin Sprinzl
Journal: Journal of Hepatology (2019)
Targeting PRMT5 Activity Inhibits the Malignancy of Hepatocellular Carcinoma by Promoting the Transcription of HNF4α
Authors: Bai-Nan Zheng, Chen-Hong Ding, Shi-Jie Chen, Kongkai Zhu, Jingwei Shao, Jifeng Feng, Wen-Ping Xu, Ling-Yan Cai, Chang-Peng Zhu, Wenhu Duan, Jin Ding, Xin Zhang, Cheng Luo, Wei-Fen Xie
Journal: Theranostics (2019)

Background: Liver cancer stem cells (LCSCs) are responsible for the initiation, progression and chemoresistance of liver cancer.However, no agent targeting LCSC is available in the clinic to date.Here, we investigated the effects of targeting protein arginine methyltransferase 5 (PRMT5), an epigenetic regulator, on LCSCs and HCC using a novel PRMT5 inhibitor DW14800.Methods: Tumor spheroid formation culture was used to enrich LCSCs and assess their self-renewal capability.Human alpha-1-antitrypsin (A1AT) ELISA, acetylated low-density lipoprotein (ac-LDL) uptake, periodic acid-Schiff (PAS) reactions and senescence associated β-galactosidase (SA-β-gal) activity assays were performed to examine the differentiation status of HCC cells.The effects of DW14800 on HCC malignancy were assessed in HCC cell lines and on an HCC xenograft model in mice.Chromatin immunoprecipitation was applied to clarify the transcriptional regulation of HNF4α by PRMT5-mediated Histone H4 arginine-3 symmetrical dimethylation (H4R3me2s).Results: Quantitative real-time PCR revealed that the expression of PRMT5 was upregulated in LCSCs.DW14800 specifically decreased the symmetrical dimethylation of arginine residues in HCC cells.Treatment of DW14800 suppressed the self-renewal capacity of LCSCs while re-establishing hepatocyte-specific characteristics in HCC cells.DW14800 displayed antitumor effects in HCC cells in vitro and in xenograft HCC in vivo.Importantly, ChIP assay showed that PRMT5 and H4R3me2s bound to the promoter region of HNF4α gene, and DW14800 increased the expression of HNF4α via reducing the H4R3me2s levels and enhancing the transcription of HNF4α.Conclusions: Our data revealed the significance of targeting PRMT5 activity in LCSC elimination and HCC differentiation, and proposed that DW14800 may represent a promising therapeutic agent for HCC in the clinic.
SAT-093-Underutilization of hospice in inpatients with cirrhosis: The NACSELD experience
Authors: Jacqueline O’leary, Rajender Reddy, Puneeta Tandon, Scott Biggins, Florence Wong, Guadalupe Garcia-Tsao, Patrick S. Kamath, Benedict Maliakkal, Jennifer Lai, Michael Fallon, Paul J. Thuluvath, Ram Subramanian, Hugo E. Vargas, Leroy Thacker, Jasmohan Bajaj
Journal: Journal of Hepatology (2019)
Effectiveness and Acceptability of Cognitive Behavior Therapy Delivery Formats in Adults With Depression
Authors: Pim Cuijpers, Hisashi Noma, Eirini Karyotaki, Andrea Cipriani, Toshi A. Furukawa
Journal: JAMA Psychiatry (2019)

IMPORTANCECognitive behavior therapy (CBT) has been shown to be effective in the treatment of acute depression.However, whether CBT can be effectively delivered in individual, group, telephone-administered, guided self-help, and unguided self-help formats remains unclear.OBJECTIVE To examine the most effective delivery format for CBT via a network meta-analysis.
Is surgery effective in patients with femoroacetabular impingement syndrome?
Authors: Ruth SF Richardson, Karen Lothe, Seb Sturridge
Journal: BMJ (2019)

### What you need to know

Femoroacetabular impingement syndrome (FAIS) describes motion related hip pain, which is caused by premature bony contact between deformities at the femoral neck and/or the acetabular rim123 (fig 1). Young, active adults are commonly affected. A prospective study in the Netherlands found that 17% of adults presenting to primary care with hip/groin pain in a year (84 adults in all) were subsequently diagnosed with FAIS on radiological imaging,4 and a further 30% had a high clinical suspicion. Impingement can damage the joint cartilage over time and lead to osteoarthritis.2356



Fig 1 
A bony enlargement on the anterior femoral neck (cam impingement), and/or at the acetabular rim (pincer impingement), causes premature contact especially during flexion and internal rotation. This repetitive trauma damages the labrum and the joint cartilage



Treatment includes conservative care with analgesics, lifestyle and activity modification, and physiotherapy, or surgery. Attempts to refine diagnostic and treatment criteria have been made;7 however, doubt remains about subcategories of FAIS and subgroup outcomes.89 Yet, the volume of arthroscopic hip surgery has grown exponentially.10 FAIS is the primary indication for this surgery.11 Within the past decade, the number of hip arthroscopies performed in the NHS has increased 10-fold. Almost 4000 surgeries are predicted annually by 2023.10 Controversy exists about how …
FRI-165-No detectable resistance to tenofovir in patients with Adefovir- and Entecavir-resistant chronic hepatitis B after 240 weeks of treatment with tenofovir disoproxil fumarate monotherapy
Authors: Jonggi Choi, Young-Suk Lim, Han Chu Lee, Yung Sang Lee, Kwan Soo Byun, Yoon Jun Kim, Byung Chul Yoo, So Young Kwon, Geum-Youn Gwak
Journal: Journal of Hepatology (2019)
SAT-439-Identification of new drug targets to prevent ischemia-induced bile toxicity using a human biliary organoid model
Authors: Floris Roos, Marcel Bijvelds, Hugo de Jonge, Herold Metselaar, Ksenia Burka, Jan Ijzermans, Monique Verstegen, Luc van der Laan
Journal: Journal of Hepatology (2019)
Expression of Prox1 in Medullary Thyroid Carcinoma Is Associated with Chromogranin A and Calcitonin Expression and with Ki67 Proliferative Index, but Not with Prognosis
Authors: Chiara Saglietti, Stefano La Rosa, Gerasimos P. Sykiotis, Igor Letovanec, Jean-Luc Bulliard, Simonetta Piana, Maxime Mermod, Tatiana Petrova, Silvia Uccella, Fausto Sessa, Massimo Bongiovanni
Journal: Endocrine Pathology (2019)
Prevalence of OCT-Defined TCFA in Relation to CFC Classified With Pressure-Temperature Sensor-Tipped Wire
Authors: Eisuke Usui, Rikuta Hamaya, Yoshihisa Kanaji, Masahiro Hoshino, Masao Yamaguchi, Masahiro Hada, Akinori Sugano, Hiroaki Ohya, Yohei Sumino, Yoshinori Kanno, Haruhito Yuki, Tadashi Murai, Tetsumin Lee, Taishi Yonetsu, Tsunekazu Kakuta
Journal: JACC. Cardiovascular imaging (2019)
Abstract P2-07-11: Prediction of the Oncotype Dx recurrence score (RS) from clinicopathologic factors
Authors: IA Voutsadakis, S Thibodeau, M Reed
Journal: Cancer Research (2019)

Abstract Background: The Oncotype Dx assay is currently used as an aid to therapeutic decisions for the adjuvant treatment of women with ER-positive, Her2-negative, lymph node-negative or -micrometastatic breast cancer. The recently reported TAILORx study showed that no or minimal benefit is derived from adjuvant chemotherapy in patients with an Oncotype Dx Recurrence Score (RS) of 25 or less. Methods: Charts of breast cancer patients that had the Oncotype Dx test in our cancer center in a nine-year period were reviewed. Data on demographic, and cancer-specific characteristics of the included patients were extracted. Predicted disease recurrence from the Oncotype Dx test was recorded and correlated with select clinicopathologic characteristics. Results: Two hundred and thirty patients with ER-positive, Her2-negative, lymph node-negative or micrometastatic breast cancer were included. Mean age was 65 years-old (SD 9.9). Two hundred and three patients (88.3%) were post-menopausal and one hundred and thirty-three patients (57.8%) were 65 years-old or older. Two hundred and nine patients (90.9%) had lymph node-negative disease. Oncotype Dx recurrence score was low (&amp;lt;11) in sixty-four patients (27.8%), intermediate (11-25) in one hundred and forty patients (60.9%) and high (&amp;gt;25) in twenty-six patients (11.3%). High tumor grade and low progesterone receptor (PR) staining by IHC were the two clinicopathologic factors most associated with a high Oncotype Dx RS (x2 test p &amp;lt;0.00001 and Fisher's exact test p &amp;lt;0.0001). A predictive index (PI) was constructed, assigning one point each for grade 3 and PR staining in 20% or less of tumor cells. A PI of 0 was observed in one hundred and thirty-eight patients (60%), a PI of 1 was observed in seventy-one patients (30.9%), and a PI of 2 was observed in twenty-one patients (9.1%). One hundred and thirty-four patients (97.1%) with a PI of 0 had a RS of 25 or less. Patients with a PI of 1 and 2 had a RS of &amp;gt;25 in 12.7% and 61.9% of cases, respectively. Conclusion: The PI based on tumor grade and PR we propose is a simple predictor of Oncotype Dx RS. 97.1% of patients with a grade 1 or 2 tumor and PR positivity in &amp;gt;20% of tumor cells had a RS of 25 or less. The Oncotype Dx test and its associated cost can therefore be avoided in these patients, especially in low-resource settings. Citation Format: Voutsadakis IA, Thibodeau S, Reed M. Prediction of the Oncotype Dx recurrence score (RS) from clinicopathologic factors [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr P2-07-11.
Abstract 12495: Plaque Progression Detected by Serial Coronary Computed Tomography Angiography Predicts Acute Coronary Syndromes
Authors: Hajime Ito, Sadako Motoyama, Masayoshi Sarai, Hideki Kawai, Hiroto Harigaya, Shino Kan, Hiroyuki Naruse, Junichi Ishi, Yukio Ozaki
Journal: Circulation (2013)

Introduction: Acute coronary syndromes (ACS) have been reported to occur at the mild to moderate stenotic lesions. However, the natural history of the plaque responsible for the future ACS is uncle...
PS-133-LXR inverse agonists reduce steatosis and fibrosis in the STAM mouse model but also improve insulin sensitivity in a high fat diet mouse clamp study
Authors: Eva Hambruch, Christian Gege, Olaf Kinzel, Katharina Hauser, Manfred Birkel, Ulrich Deuschle, Claus Kremoser
Journal: Journal of Hepatology (2019)
Are corticosteroid injections needed after needling and lavage of calcific tendinitis? Randomised, double-blind, non-inferiority trial
Authors: Christelle Darrieutort-Laffite, Stephane Varin, Guillaume Coiffier, Jean-David Albert, Lucie Planche, Yves Maugars, Grégoire Cormier, Benoit Le Goff
Journal: Annals of the Rheumatic Diseases (2019)

Objective Steroid injections are common after an ultrasound-guided puncture and lavage (UGPL) of calcific tendonitis of the rotator cuff. However, steroids may prevent calcification resorption and negatively affect tendon healing. Our study was designed to determine whether saline solution was non-inferior to steroids in the prevention of acute pain reactions in the week following UGPL. Methods This was a randomised, double-blinded, controlled non-inferiority trial with 12-month follow-up. We included 132 patients (66 in each group) with symptomatic calcification measuring more than 5 mm. Patients received 1 mL of saline or steroid (methylprednisolone 40 mg) in the subacromial bursa at the end of UGPL. Primary outcome was the maximal pain during the week following the procedure with a prespecified non-inferiority margin of 10 mm (0–100 visual analogue scale). Secondary outcomes included pain at rest and during activity, function (disabilities of the arm, shoulder and hand score) and radiological evolution of the calcification over the 12-month follow-up. Results The estimated mean difference in the first week’s maximal pain between these two groups was 11.76 (95% CI 3.78 to 19.75). Steroids significantly improved VAS pain at rest and during activities, as well as function at 7 days and 6 weeks. They did not change the rate of calcification resorption, which occurred in 83% and 74% of patients at 12 months in the saline and steroid groups. Conclusion Non-inferiority of saline when compared with steroids could not be established. However, steroid injection improved pain in the 6 weeks following the procedure, and function in the 3 months after, with no significant effect on calcification resorption. Trial registration number NTC02403856.
Factors Associated With Opioid Use in Patients Hospitalized for Acute Pancreatitis
Authors: Bechien U. Wu, Rebecca K. Butler, Wansu Chen
Journal: JAMA Network Open (2019)

<h3>Importance</h3> Limited guidance exists regarding the optimal approach to management of pain in acute pancreatitis (AP). <h3>Objectives</h3> To investigate sources of variability in opioid use for treatment of acute pain in patients hospitalized for AP and to explore a potential association of opioid prescribing patterns with length of stay. <h3>Design, Setting, and Participants</h3> This retrospective cohort study included 4307 patients 18 years and older hospitalized for AP in a community-based integrated health care system, from January 1, 2008, to June 30, 2015. Analysis began in November 2017. <h3>Exposures</h3> Opioid use was quantified by morphine equivalent dose (MED). <h3>Main Outcomes and Measures</h3> Three analyses were performed: (1) factors associated with increased opioid administration during the initial 12 hours of hospitalization (baseline), (2) association of baseline opioid use with length of stay, and (3) frequency of opioid use 90 days after hospital discharge (persistent use). <h3>Results</h3> The cohort included 4307 patients (median [interquartile range] age, 57.4 [44.0-70.2] years; 2241 women [52.0%]) with AP. At baseline, 3443 patients (79.9%) received opioids, and 388 patients (9.6%) had persistent opioid use after discharge. After adjusting for pain and other clinical factors, women received less MED than men (adjusted event ratio, 0.83; 95% CI, 0.79-0.86;<i>P</i> &lt; .001). Hispanic and Asian patients received less MED than non-Hispanic white patients (adjusted event ratio, 0.85; 95% CI, 0.81-0.90;<i>P</i> &lt; .001; and adjusted event ratio, 0.79; 95% CI, 0.72-0.86;<i>P</i> &lt; .001, respectively). Alcohol-related AP etiology was associated with increased MED vs gallstone disorders (adjusted event ratio, 1.11; 95% CI, 1.05-1.18;<i>P</i> &lt; .001). Two of 13 hospitals administered significantly less opioids compared with the others. Median (interquartile range) length of stay was independently associated with MED at baseline, with 3.0 (2.1-4.5) days among patients not receiving opioids vs 5.0 (3.2-8.7) days among patients in the highest quintile of MED (<i>P</i> &lt; .001). <h3>Conclusions and Relevance</h3> In addition to pain and disease severity, opioid use varied by etiology of AP, sex, race/ethnicity, and institution of treatment. Increased opioid use at baseline was associated with longer hospitalization. These findings suggest opportunities for improved approaches to pain control for patients with AP.
SAT-046-Clinical impact of rectal colonization by multidrug-resistant bacteria in patients with decompensated cirrhosis
Authors: Maria Hernandez-Tejero, Francesc Marco Reverte, Fatima Aziz, Cristina Pitart, Irene Campo, Adrià Carpio, Ester López-Suñé, Santiago Ortiz, Gabriel Mezzano, Pere Ginès, Alex Soriano, Jordi Vila, Javier Fernandez
Journal: Journal of Hepatology (2019)