tbuckley/cabot-search huggingface dataset:
Head Injury Deaths on the Rise
Authors: Bridget M. Kuehn
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Community Training Center: An Educational-Behavioral-Social Systems Model for Rehabilitating Psychiatric Patients, <i>by Michael D. Spiegler, Ph.D., and Haig Agigian, M.S.W., A.C.S.W. New York, N. Y., Brunner/Mazel, 1977, 363 pp., $15.00</i>
Authors: John J. Schwab
Journal: American Journal of Psychiatry (1979)
3D Printing of Bioinspired Biomaterials for Tissue Regeneration
Authors: Tian Li, Jiang Chang, Yufang Zhu, Chengtie Wu
Journal: Advanced Healthcare Materials (2020)

Biological systems, which possess remarkable functions and excellent properties, are gradually becoming a source of inspiration for the fabrication of advanced tissue regeneration biomaterials due to their hierarchical structures and novel compositions. It would be meaningful to learn and transfer the characteristics of creatures to biomaterials design. However, traditional strategies cannot satisfy the design requirements of the complicated bioinspired materials for tissue regeneration. 3D printing, as a rapidly developing new technology that can accurately achieve multimaterial and multiscale fabrication, is capable of optimizing the fabrication of bioinspired materials with complex composition and structure. This review summarizes the recent developments in 3D-printed bioinspired biomaterials for multiple tissue regeneration, and especially highlights the progresses on i) traditional bioinspired designs for biomaterials fabrication, ii) biological composition inspired designs for the 3D-printed biomaterials, and iii) biological structure inspired designs for the 3D-printed biomaterials. Finally, the challenges and prospects for the development of 3D-printed bioinspired biomaterials are discussed.
Quality Measure Development and Associated Spending by the Centers for Medicare &amp; Medicaid Services
Authors: Rishi K. Wadhera, Jose F. Figueroa, Karen E. Joynt Maddox, Lisa S. Rosenbaum, Dhruv S. Kazi, Robert W. Yeh
Journal: JAMA (2020)

This study uses data from the publicly available Centers for Medicare & Medicaid Services (CMS) Inventory Tool to determine the proportion of CMS quality measures that are used or finalized for use in a CMS program, under development or consideration for use, or not in use.
Use of Etanercept in a Series of Pediatric Patients With Stevens-Johnson Syndrome–Toxic Epidermal Necrolysis Spectrum Disease
Authors: Philip Eliades, Maíra Fonseca, Joanna Harp
Journal: JAMA Dermatology (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
A Cost-Benefit Analysis of Bortezomib, Lenalidomide, and Bortezomib/Lenalidomide Combination Therapy for Newly Diagnosed Multiple Myeloma
Authors: Mark A. Fiala, Tanya M. Wildes, Gunjan L. Shah, Armin Ghobadi, Mark A. Schroeder, Keith E. Stockerl-Goldstein, Ravi Vij
Journal: Blood (2017)
Association of Surgeon Case Numbers of Pancreaticoduodenectomies vs Related Procedures With Patient Outcomes to Inform Volume-Based Credentialing
Authors: Kyle H. Sheetz, Usha Nuliyalu, Hari Nathan, Christopher J. Sonnenday
Journal: JAMA Network Open (2020)

<h3>Importance</h3> Despite growing interest from various surgical societies and patient safety organizations, concerns remain that volume-based credentialing standards are arbitrary and may fail to recognize a surgeon’s full scope of practice. <h3>Objective</h3> To evaluate whether surgeon experience with related procedures was associated with better outcomes for pancreaticoduodenectomy compared with procedure-specific experience alone. <h3>Design, Setting, and Participants</h3> This proof-of-concept cohort study used the all-payer State Inpatient Databases from 6 geographically diverse states to identify all operations for surgeons who performed at least 1 pancreaticoduodenectomy from January 1, 2012, to December 31, 2014. Each surgeon’s mean annual volume for pancreaticoduodenectomies and related complex hepatopancreatobiliary (HPB) procedures was calculated. Outcomes for surgeons above and below a threshold of 12 pancreaticoduodenectomies per year were evaluated. Whether related HPB procedure volume was also associated with better outcomes for surgeons not meeting the procedure-specific threshold was also evaluated. Data were analyzed from March 2 through 20, 2019. <h3>Main Outcomes and Measures</h3> Thirty-day mortality and complications. <h3>Results</h3> The study cohort included 176 043 patients, of whom 92 064 were female (52.3%), with a mean (SD) age of 59 (17) years. Within 270 hospitals, only 54 of 1028 surgeons (5.3%) met the mean pancreaticoduodenectomy volume threshold from 2012 to 2014. In-hospital mortality after pancreaticoduodenectomy was lower for surgeons who performed 12 or more procedures per year (1.8% [95% CI, 1.1%- 2.4%] vs 4.7% [95% CI, 4.0%-5.4%]; odds ratio, 0.32; 95% CI, 0.21-0.50). However, in-hospital mortality varied 7-fold among surgeons who did not meet the threshold (1.2% [95% CI, 0.8%-1.6%] to 8.4% [95% CI, 7.9%-8.9%]). Increasing HPB case volume was associated with better outcomes for pancreaticoduodenectomy in this group. For example, surgeons performing 2 or fewer pancreaticoduodenectomies annually would need to perform an additional 27 related HPB procedures to match the in-hospital mortality rate of surgeons performing 12 or more pancreaticoduodenectomies. <h3>Conclusions and Relevance</h3> In this proof-of-concept cohort study, few surgeons met even modest annual volume thresholds for pancreaticoduodenectomy. The findings suggest that inclusion of related procedure volumes may safely expand the cohort of surgeons credentialed to perform certain procedures under volume-based standards.
Ventilator Triage Policies During the COVID-19 Pandemic at U.S. Hospitals Associated With Members of the Association of Bioethics Program Directors
Authors: Armand H. Matheny Antommaria, Tyler S. Gibb, Amy L. McGuire, Paul Root Wolpe, Matthew K. Wynia, Megan K. Applewhite, Arthur Caplan, Douglas S. Diekema, D. Micah Hester, Lisa Soleymani Lehmann, Renee McLeod-Sordjan, Tamar Schiff, Holly K. Tabor, Sarah E. Wieten, Jason T. Eberl
Journal: Annals of Internal Medicine (2020)

The coronavirus disease 2019 pandemic has or threatens to overwhelm health care systems. Many institutions are developing ventilator triage policies.
Genome-wide selection and genetic improvement during modern maize breeding
Authors: Baobao Wang, Zechuan Lin, Xin Li, Yongping Zhao, Binbin Zhao, Guangxia Wu, Xiaojing Ma, Hai Wang, Yurong Xie, Quanquan Li, Guangshu Song, Dexin Kong, Zhigang Zheng, Hongbin Wei, Rongxin Shen, Hong Wu, Cuixia Chen, Zhaodong Meng, Tianyu Wang, Yu Li, Xinhai Li, Yanhui Chen, Jinsheng Lai, Matthew B. Hufford, Jeffrey Ross-Ibarra, Hang He, Haiyang Wang
Journal: Nature Genetics (2020)
Abstract 11748: Mechanical Circulatory Supportmeasures of Adjustment and Quality of Life: Findings on Self-Reported Mental Health
Authors: Kathleen L Grady, Johsua Rutsohn, Paul Goetz, Michael A Kallen, Jonathan Rich, Clyde Yancy, Duc Thinh Pham, David Cella, Sarah Buono, David Beiser, Catherine Murks, Christopher S Lee, Quin Denfeld, Dipanjan Bannerjee, Michael Kiernan, Joann Lindenfeld, Colleen McIlvennan, Larry Allen, Liviu Klein, Mary N Walsh, Bernice Ruo, Elizabeth A Hahn
Journal: Circulation (2018)

Introduction: Mental health in patients (pts) with advanced heart failure (HF) who undergo implantation of mechanical circulatory support (MCS) is poorly described. Further research is needed to id...
Evaluating the Prognostic Utility of Intermittent vs Continuous Electroencephalography in Comatose Survivors of Cardiac Arrest
Authors: Matthew B. Maas
Journal: JAMA Network Open (2020)

Jonathan Elmer, MD, MS; Patrick J. Coppler, PA-C; Pawan Solanki, MD; M. Brandon Westover, MD, PhD; Aaron F. Struck, MD; Maria E. Baldwin, MD; Michael C. Kurz, MD; Clifton W. Callaway, MD, PhD
PENet—a scalable deep-learning model for automated diagnosis of pulmonary embolism using volumetric CT imaging
Authors: Shih-Cheng Huang, Tanay Kothari, Imon Banerjee, Chris Chute, Robyn L. Ball, Norah Borus, Andrew Huang, Bhavik N. Patel, Pranav Rajpurkar, Jeremy Irvin, Jared Dunnmon, Joseph Bledsoe, Katie Shpanskaya, Abhay Dhaliwal, Roham Zamanian, Andrew Y. Ng, Matthew P. Lungren
Journal: npj Digital Medicine (2020)

Abstract Pulmonary embolism (PE) is a life-threatening clinical problem and computed tomography pulmonary angiography (CTPA) is the gold standard for diagnosis. Prompt diagnosis and immediate treatment are critical to avoid high morbidity and mortality rates, yet PE remains among the diagnoses most frequently missed or delayed. In this study, we developed a deep learning model—PENet, to automatically detect PE on volumetric CTPA scans as an end-to-end solution for this purpose. The PENet is a 77-layer 3D convolutional neural network (CNN) pretrained on the Kinetics-600 dataset and fine-tuned on a retrospective CTPA dataset collected from a single academic institution. The PENet model performance was evaluated in detecting PE on data from two different institutions: one as a hold-out dataset from the same institution as the training data and a second collected from an external institution to evaluate model generalizability to an unrelated population dataset. PENet achieved an AUROC of 0.84 [0.82–0.87] on detecting PE on the hold out internal test set and 0.85 [0.81–0.88] on external dataset. PENet also outperformed current state-of-the-art 3D CNN models. The results represent successful application of an end-to-end 3D CNN model for the complex task of PE diagnosis without requiring computationally intensive and time consuming preprocessing and demonstrates sustained performance on data from an external institution. Our model could be applied as a triage tool to automatically identify clinically important PEs allowing for prioritization for diagnostic radiology interpretation and improved care pathways via more efficient diagnosis.
Primary Pancreatic Yolk Sac Tumor Presenting as Diffusely Enlarged Pancreas in Initial 18F-FDG PET/CT
Authors: Huimin Sui, Zhaohui Zhu, Zheng Li, Yaping Luo
Journal: Clinical Nuclear Medicine (2020)

Abstract Yolk sac tumor is a rare and highly malignant germ cell tumor. We report a case of yolk sac tumor primarily in the pancreas in a 32-year-old man. He presented with pancreatitis at presentation with significantly increased serum alpha-fetoprotein (AFP). 18 F-FDG PET/CT revealed diffuse enlargement of the pancreas in the neck, body, and tail portion with homogeneously increased FDG uptake, similar to the change of pancreatitis. The lesion progressively developed to a huge pancreatic mass in the follow-up images, and endoscopic ultrasonography-guided aspiration biopsy of the pancreatic mass confirmed the diagnosis of yolk sac tumor.
Strong associations and moderate predictive value of early symptoms for SARS-CoV-2 test positivity among healthcare workers, the Netherlands, March 2020
Authors: Alma Tostmann, John Bradley, Teun Bousema, Wing-Kee Yiek, Minke Holwerda, Chantal Bleeker-Rovers, Jaap ten Oever, Corianne Meijer, Janette Rahamat-Langendoen, Joost Hopman, Nannet van der Geest-Blankert, Heiman Wertheim
Journal: Eurosurveillance (2020)

Healthcare workers (n = 803) with mild symptoms were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (n = 90 positive) and asked to complete a symptom questionnaire. Anosmia, muscle ache, ocular pain, general malaise, headache, extreme tiredness and fever were associated with positivity. A predictive model based on these symptoms showed moderate discriminative value (sensitivity: 91.2%; specificity: 55.6%). While our models would not justify presumptive SARS-CoV-2 diagnosis without molecular confirmation, it can contribute to targeted screening strategies.
Screening and Treatment Outcomes in Adults and Children With Type 1 Diabetes and Asymptomatic Celiac Disease: The CD-DIET Study
Authors: Farid H. Mahmud, Antoine B.M. Clarke, Kariym C. Joachim, Esther Assor, Charlotte McDonald, Fred Saibil, Heather A. Lochnan, Zubin Punthakee, Amish Parikh, Andrew Advani, Baiju R. Shah, Bruce A. Perkins, Caroline S. Zuijdwijk, David R. Mack, Dror Koltin, Emilia N. De Melo, Eugene Hsieh, Geetha Mukerji, Jeremy Gilbert, Kevin Bax, Margaret L. Lawson, Maria Cino, Melanie D. Beaton, Navaaz A. Saloojee, Olivia Lou, Patricia H. Gallego, Premysl Bercik, Robyn L. Houlden, Ronnie Aronson, Susan E. Kirsch, William G. Paterson, Margaret A. Marcon
Journal: Diabetes Care (2020)

OBJECTIVE To describe celiac disease (CD) screening rates and glycemic outcomes of a gluten-free diet (GFD) in patients with type 1 diabetes who are asymptomatic for CD. RESEARCH DESIGN AND METHODS Asymptomatic patients (8–45 years) were screened for CD. Biopsy-confirmed CD participants were randomized to GFD or gluten-containing diet (GCD) to assess changes in HbA1c and continuous glucose monitoring over 12 months. RESULTS Adults had higher CD-seropositivity rates than children (6.8% [95% CI 4.9–8.2%, N = 1,298] vs. 4.7% [95% CI 3.4–5.9%, N = 1,089], P = 0.035) with lower rates of prior CD screening (6.9% vs. 44.2%, P &amp;lt; 0.0001). Fifty-one participants were randomized to a GFD (N = 27) or GCD (N = 24). No HbA1c differences were seen between the groups (+0.14%, 1.5 mmol/mol; 95% CI −0.79 to 1.08; P = 0.76), although greater postprandial glucose increases (4-h +1.5 mmol/L; 95% CI 0.4–2.7; P = 0.014) emerged with a GFD. CONCLUSIONS CD is frequently observed in asymptomatic patients with type 1 diabetes, and clinical vigilance is warranted with initiation of a GFD.
Epigenetic signatures associated with imprinted paternally expressed genes in the Arabidopsis endosperm [Erratum: Dec. 2019, v.20(1), p.182]
Authors: Jordi Moreno-Romero, Gerardo Del Toro-De León, Vikash Kumar Yadav, Juan Santos-González, Claudia Köhler
Journal: Genome biology (2019)
Challenges in Prediction, Diagnosis, and Treatment of Alcohol Withdrawal in Medically Ill Hospitalized Patients
Authors: Thomas D. Brothers, Paxton Bach
Journal: JAMA Internal Medicine (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
FuMeGA Criteria for Visual Assessment of Postoperative 18F-Fluorocholine PET in Patients With Glioma
Authors: Ana María García Vicente, Francisco José Pena Pardo, Elena Lozano Setien, Hernán Sandoval Valencia, Maikal Villena Martín
Journal: Clinical Nuclear Medicine (2020)

Abstract Postoperative assessment is crucial in the imaging follow-up and prognosis in patients with glioma. Whereas grade of resection is defined attending to the gadolinium enhancement in early postoperative MRI, no metabolical criteria exist for postoperative PET interpretation. Based on our prospective and multicenter FuMeGA (Functional and Metabolic Glioma Analysis) ongoing study, we propose criteria for the visual interpretation of 18 F-fluorocholine PET scans in patients undergoing brain tumor resection. The different imaging characteristics between MRI and PET may explain the discordances regarding to the postresection status with both techniques.
Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction
Authors: Qin Jiang, Chang Liu, Chao-Peng Li, Shan-Shan Xu, Mu-Di Yao, Hui-Min Ge, Ya-Nan Sun, Xiu-Miao Li, Shu-Jie Zhang, Kun Shan, Bai-Hui Liu, Jin Yao, Chen Zhao, Biao Yan
Journal: Journal of Clinical Investigation (2020)

Diabetic retinopathy (DR) is the leading cause of blindness in working-age adults. Vascular pericyte degeneration is the predominant clinical manifestation of DR, yet the mechanism governing pericyte degeneration is poorly understood. Circular RNAs (circRNAs) play important roles in multiple biological processes and disease progression. Here, we investigated the role of circRNA in pericyte biology and diabetes-induced retinal vascular dysfunction. cZNF532 expression was upregulated in pericytes under diabetic stress, in the retinal vessels of a diabetic murine model, and in the vitreous humor of diabetic patients. cZNF532 silencing reduced the viability, proliferation, and differentiation of pericytes and suppressed the recruitment of pericytes toward endothelial cells in vitro. cZNF532 regulated pericyte biology by acting as a miR-29a-3p sponge and inducing increased expression of NG2, LOXL2, and CDK2. Knockdown of cZNF532 or overexpression of miR-29a-3p aggravated streptozotocin-induced retinal pericyte degeneration and vascular dysfunction. By contrast, overexpression of cZNF532 or inhibition of miR-29a-3p ameliorated human diabetic vitreous-induced retinal pericyte degeneration and vascular dysfunction. Collectively, these data identify a circRNA-mediated mechanism that coordinates pericyte biology and vascular homeostasis in DR. Induction of cZNF532 or antagonism of miR-29a-3p is an exploitable therapeutic approach for the treatment of DR.
Multisystemic therapy versus management as usual in the treatment of adolescent antisocial behaviour (START): 5-year follow-up of a pragmatic, randomised, controlled, superiority trial
Authors: Peter Fonagy, Stephen Butler, David Cottrell, Stephen Scott, Stephen Pilling, Ivan Eisler, Peter Fuggle, Abdullah Kraam, Sarah Byford, James Wason, Jonathan A Smith, Alisa Anokhina, Rachel Ellison, Elizabeth Simes, Poushali Ganguli, Elizabeth Allison, Ian M Goodyer
Journal: The Lancet Psychiatry (2020)
HER2-Low Breast Cancer: Pathological and Clinical Landscape
Authors: Paolo Tarantino, Erika Hamilton, Sara M. Tolaney, Javier Cortes, Stefania Morganti, Emanuela Ferraro, Antonio Marra, Giulia Viale, Dario Trapani, Fatima Cardoso, Frédérique Penault-Llorca, Giuseppe Viale, Fabrice Andrè, Giuseppe Curigliano
Journal: Journal of Clinical Oncology (2020)

Article Tools REVIEW ARTICLES Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.19.02488 Journal of Clinical Oncology - published online before print April 24, 2020 PMID: 32330069 HER2-Low Breast Cancer: Pathological and Clinical Landscape Paolo Tarantino, MD1,2xPaolo TarantinoSearch for articles by this author; Erika Hamilton, MD3xErika HamiltonSearch for articles by this author; Sara M. Tolaney, MD, MPH4xSara M. TolaneySearch for articles by this author; Javier Cortes, MD, PhD5,6xJavier CortesSearch for articles by this author; Stefania Morganti, MD1,2xStefania MorgantiSearch for articles by this author; Emanuela Ferraro, MD1,2xEmanuela FerraroSearch for articles by this author; Antonio Marra, MD1,2xAntonio MarraSearch for articles by this author; Giulia Viale, MD1,2xGiulia VialeSearch for articles by this author; Dario Trapani, MD1,2xDario TrapaniSearch for articles by this author; Fatima Cardoso, MD7xFatima CardosoSearch for articles by this author; Frédérique Penault-Llorca, MD, PhD8,9xFrédérique Penault-LlorcaSearch for articles by this author; Giuseppe Viale, MD1,2xGiuseppe VialeSearch for articles by this author; Fabrice Andrè, MD, PhD10xFabrice AndrèSearch for articles by this author; and Giuseppe Curigliano, MD, PhD1,2xGiuseppe CuriglianoSearch for articles by this author Show More 1European Institute of Oncology IRCCS, Milan, Italy2University of Milan, Milan, Italy3Sarah Cannon Research Institute/Tennessee Oncology, Nashville, TN4Dana-Farber Cancer Institute, Boston, MA5IOB Institute of Oncology, Quiron Group, Madrid and Barcelona, Spain6Vall d’Hebron Institute of Oncology, Barcelona, Spain7Breast Unit Champalimaud Clinical Center/Champalimaud Foundation, Lisbon, Portugal8Jean Perrin Comprehensive Cancer Center, Department of Pathology and Tumor Biology, Centre Jean Perrin, Clermont-Ferrand, France9UMR INSERM 1240 IMoST, Université Clermont Auvergne, Villejuif, France10Department of Medical Oncology, Gustave Roussy, Villejuif, FranceF.A. and G.C. contributed equally to this work. https://doi.org/10.1200/JCO.19.02488 First Page Full Text PDF Figures and Tables © 2020 by American Society of Clinical Oncology