tbuckley/cabot-search huggingface dataset:
TCT CONNECT-215 Demographics and In-Hospital Outcomes of COVID-19 Patients Undergoing an Invasive Strategy for Acute Coronary Syndrome: The Global Multi-Centre Prospective COVID-ACS Registry
Authors: Thomas Kite, Chris Gale, Adriano Caixeta, Parham Sadeghipour, Manel Sabate, Angel Iniesta, Pilar Jimenez-Quevedo, Luciano Candilio, Stephen Hoole, Nick Palmer, Albert Ariza Solé, Olga Bockeria, Alim Namitokov, Otilia Cristea, Annika Eriksson, Andrew Morrow, Flavien Vincent, Hector Hugo Escutia-Cuevas, Charley Budgeon, Gregg Stone, Peter Ludman, Nick Curzen, Colin Berry, Anthony Gershlick
Journal: Journal of the American College of Cardiology (2020)
TCT CONNECT-7 Everolimus-Eluting Stent Versus Bare-Metal Stent in ST-Segment Elevation Myocardial Infarction: 10-Year Follow-Up of the Multicenter Randomized Controlled Examination Trial
Authors: Salvatore Brugaletta, Josep Gomez Lara, Luis Ortega-Paz, Victor Alfonso Jimenez Diaz, Marcelo Jimenez, Pilar Jimenez-Quevedo, Roberto Diletti, Vicente Mainar Tello, Gianluca Campo, Antonio Silvestro, Jaume Maristany, Xacobe Flores-Rios, Loreto Oyarzabal, Antonio Alejandro De Miguel Castro, Andres Iñiguez Romo, Antonio Serra, Luis Nombela Franco, Alfonso Ielasi, Maurizio Tespili, Mattie Lenzen, Nieves Gonzalo, Matteo Tebaldi, Simone Biscaglia, Juan Rodriguez, Soheil Al-Shaibani, Victor Arevalos, Rafael Romaguera, Joan Antoni Gomez-Hospital, Patrick Serruys, Manel Sabate
Journal: Journal of the American College of Cardiology (2020)
Dyschromic Nails, Exertional Dyspnea, and Lower Extremity Edema
Authors: Soumya Chatterjee, Elliott Chandler Dasenbrook
Journal: JAMA (2020)

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Effectiveness of online psychological and psychoeducational interventions to prevent depression: Systematic review and meta-analysis of randomized controlled trials
Authors: Alina Rigabert, Emma Motrico, Patricia Moreno-Peral, Davinia María Resurrección, Sonia Conejo-Cerón, Pim Cuijpers, Carmen Martín-Gómez, Yolanda López-Del-Hoyo, Juan Ángel Bellón
Journal: Clinical Psychology Review (2020)
TCT CONNECT-362 Natural Vascular Scaffolding Therapy Shows Favorable Biocompatibility and Protection of Elastin Content in Comparison to Balloon Angioplasty and Stent in Peripheral Arteries of LDLR-Knockout Hypercholesterolemic Swine
Authors: Grzegorz Kaluza, Katalin Kauser, Karl Van Wygerden, Yanping Cheng, R.B. Hayes, Blake Anderson, Gerard Conditt, Serge Rousselle, Juan Granada
Journal: Journal of the American College of Cardiology (2020)
Omacetaxine Mepesuccinate for Patients with Higher-Risk MDS and CMML after Failure of Hypomethylating Agents: A Phase II Trial
Authors: Nicholas J Short, Guillermo Garcia-Manero, Kiran Naqvi, Steven Kornblau, Koichi Takahashi, Guillermo Montalban-Bravo, Rita Khouri, Michael Andreeff, Marina Konopleva, Courtney D. DiNardo, Yesid Alvarado, Marie Ghosn, Zeev Estrov, Prithviraj Bose, Rubiul Islam, Xiao Dong, Jorge E. Cortes, Hagop M. Kantarjian, Elias J. Jabbour
Journal: Blood (2017)
TCT CONNECT-262 Percutaneous Coronary Intervention of Long Coronary Lesions With the Bioabsorbable Polymer-Coated, Everolimus-Eluting Synergy 48-mm Stent: Primary Outcomes of the EVOLVE 48 Study
Authors: Dimitrios Karmpaliotis, Robert Stoler, Simon Walsh, Seif El-Jack, Srini Potluri, Jeffrey Moses, Keith Oldroyd, Adrian Banning, Mark Webster, Azfar Zaman, Willis Wu, Mudassar Ahmed, Paul Underwood, Dominic Allocco
Journal: Journal of the American College of Cardiology (2020)
Hematopoietic Stem Cell Transplantation Positively Affects the Natural History of Cancer in Nijmegen Breakage Syndrome
Authors: Beata Wolska-Kusnierz, Agata Pastorczak, Wojciech Fendler, Anna Wakulinska, Bozena Dembowska-Baginska, Edyta Heropolitanska-Pliszka, Barbara Piątosa, Barbara Pietrucha, Krzysztof Kałwak, Marek Ussowicz, Anna Pieczonka, Katarzyna Drabko, Monika Lejman, Sylwia Koltan, Jolanta Gozdzik, Jan Styczynski, Alina Fedorova, Natalia Miakova, Elena Deripapa, Larysa Kostyuchenko, Zdenka Krenova, Eva Hlavackova, Andrew R. Gennery, Karl-Walter Sykora, Sujal Ghosh, Michael H. Albert, Dmitry Balashov, Mary Eapen, Peter Svec, Markus G. Seidel, Sara S. Kilic, Agnieszka Tomaszewska, Ewa Wiesik-Szewczyk, Alexandra Kreins, Johann Greil, Jochen Buechner, Bendik Lund, Hanna Gregorek, Krystyna Chrzanowska, Wojciech Mlynarski
Journal: Clinical Cancer Research (2020)

Nijmegen breakage syndrome (NBS) is a DNA repair disorder with a high predisposition to hematologic malignancies.We describe the natural history of NBS, including cancer incidence, risk of death, and the potential effectiveness of hematopoietic stem cell transplantation (HSCT) in preventing both pathologies: malignancy and immunodeficiency.Among 241 patients with NBS enrolled in the study from 11 countries, 151 (63.0%) patients were diagnosed with cancer. Incidence rates for primary and secondary cancer, tumor characteristics, and risk factors affecting overall survival (OS) were estimated. The cumulative cancer incidence was 40.21% ± 3.5% and 77.78% ± 3.4% at 10 years and 20 years of follow-up, respectively. Most of the tumors n = 95 (62.9%) were non-Hodgkin lymphomas. Overall, 20 (13.2%) secondary malignancies occurred at a median age of 18 (interquartile range, 13.7-21.5) years. The probability of 20-year overall survival (OS) for the whole cohort was 44.6% ± 4.5%. Patients who developed cancer had a shorter 20-year OS than those without malignancy (29.6% vs. 86.2%; P < 10-5). A total of 49 patients with NBS underwent HSCT, including 14 patients transplanted before malignancy. Patients with NBS with diagnosed cancer who received HSCT had higher 20-year OS than those who did not (42.7% vs. 30.3%; P = 0.038, respectively). In the group of patients who underwent preemptive transplantation, only 1 patient developed cancer, which is 6.7 times lower as compared with nontransplanted patients [incidence rate ratio 0.149 (95% confidence interval, 0.138-0.162); P < 0.0001].There is a beneficial effect of HSCT on the long-term survival of patients with NBS transplanted in their first complete remission of cancer.
Apoptotic activity and mechanism of CDDO and related synthetic triterpenoids in prostate cancer
Authors: Ranxin Shi, Marc Hyer, Maryla Krajewska, Colin Meyer, Irina Lebedeva, Paul Fisher, John Reed
Journal: Cancer Research (2008)

3216  Triterpenoids CDDO, (2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid), CDDO-Im (imidazole derivative), and CDDO-Me (methyl ester derivative) represent a novel group of synthetic small molecules currently being evaluated as anti-cancer agents in pre-clinical models and in clinical trials. In the present study, the activity of CDDO, CDDO-Me, and CDDO-Im was examined against a panel of prostate cancer cell lines. We found that CDDO analogs at submicromolar concentrations induce apoptosis of cultured prostate cancer (PCa) cell lines, LNCaP, ALVA31, Du145, PC3, and PPC1, with lethal dose 50% (LD50) of ~1 μM for CDDO-Me and the imidazole analog (CDDO-Im). These compounds induced apoptosis of PCa cells as characterized by cleavage of caspases-3, -7, -8, -9, -10, BID, and PARP. Triterpenoid-mediated cell death was blocked by a broad-spectrum caspase inhibitor (z-VAD-fmk), indicating a caspase-dependent mechanism. Moreover, triterpenoid-induced cell death was abolished by caspase-8-targeting small interfering (si) RNA, suggesting a death mechanism mediated through the extrinsic apoptosis pathway. To explore the mechanism(s) involved in caspase-8 activation, we examined cell surface expression of death receptors DR4 and DR5 following triterpenoid treatment. Cell surface DR4 and DR5 expression was significantly up-regulated by CDDO or CDDO-Im but not by CDDO-Me. DR4 and DR5 knockdown with siRNA significantly inhibited apoptosis induced by CDDO and CDDO-Im but had no effect on CDDO-Me-induced killing, suggesting that CDDO and CDDO-Im induce apoptosis by a different mechanism than CDDO-Me. We also observed that Bcl-XL over-expression inhibits triterpenoid-mediated killing of PCa cell line Du145, suggesting that the intrinsic pathway (via mitochondria) also participates in triterpenoid-mediated killing. Finally, the anti-tumor activity of CDDO-Me was demonstrated in a nude rat tumor xenograft (Du145) model. In summary, CDDO-based compounds induce caspase-8-dependent apoptosis of prostate cancer cells, suggesting a novel cytotoxic mechanism that should be further evaluated as a potential novel therapy for hormone refractory prostate cancers. (Supported by NIH CA-113318).
Therapeutic manipulation of gut microbiota by polysaccharides of <i>Wolfiporia cocos</i> reveals the contribution of the gut fungi-induced PGE<sub>2</sub> to alcoholic hepatic steatosis
Authors: Shanshan Sun, Kai Wang, Li Sun, Baosong Cheng, Shanshan Qiao, Huanqin Dai, Wenyu Shi, Juncai Ma, Hongwei Liu
Journal: Gut Microbes (2020)

Alcohol abuse and alcoholic liver diseases (ALD) have been worldwide spread. Chronic alcoholism-induced overgrowth of intestinal bacteria and fungi together with the enteric dysbiosis are important pathogenic mechanisms in ALD. We demonstrated that the water-insoluble polysaccharides (WIP) from Wolfporia cocos effectively ameliorated the hepatic inflammatory injury and fat accumulation through modulating gut microbiota in mice with alcoholic hepatic steatosis (AHS). Oral administration of WIP significantly enhanced the ratio of Firmictues to Proteobacteria, increased the abundance of Lachnospiraceae including Ruminoclostridum and unidentified_clostridials, and inhibited the ethanol-induced fungal overgrowth. Treatment with WIP activated the PPAR-γ signaling and reduced the inflammation in the colonic epithelia cell, facilitating a hypoxic state that suppresses the overgrowth of fungi and Proteobacteria in the gut. In addition, we found an overwhelming increase of the commensal fungus Meyerozyma guilliermondii in the feces of mice with AHS by culturing and ITS sequencing. Inoculation of M. guilliermondii into fungi-free mice aggravated the features of AHS. M. guilliermondii was found to generate PGE2 by biotransformation of arachidonic acid. Furthermore, the gut fungi (M. guilliermondii)-induced PGE2 production in the liver was confirmed as one of the mechanisms in the chronic AHS. The current study supports the manipulation of the gut microbiota (bacteria and fungi) as an effective and alternative strategy for alleviating ALD.
YAP Orchestrates Heterotypic Endothelial Cell Communication via HGF/c-MET Signaling in Liver Tumorigenesis
Authors: Stefan Thomann, Sofia M.E. Weiler, Simone Marquard, Fabian Rose, Claudia R. Ball, Marcell Tóth, Teng Wei, Carsten Sticht, Sarah Fritzsche, Stephanie Roessler, Carolina De La Torre, Eduard Ryschich, Olga Ermakova, Carolin Mogler, Daniel Kazdal, Norbert Gretz, Hanno Glimm, Eugen Rempel, Peter Schirmacher, Kai Breuhahn
Journal: Cancer Research (2020)

Abstract The oncogene yes-associated protein (YAP) controls liver tumor initiation and progression via cell extrinsic functions by creating a tumor-supporting environment in conjunction with cell autonomous mechanisms. However, how YAP controls organization of the microenvironment and in particular the vascular niche, which contributes to liver disease and hepatocarcinogenesis, is poorly understood. To investigate heterotypic cell communication, we dissected murine and human liver endothelial cell (EC) populations into liver sinusoidal endothelial cells (LSEC) and continuous endothelial cells (CEC) through histomorphological and molecular characterization. In YAPS127A-induced tumorigenesis, a gradual replacement of LSECs by CECs was associated with dynamic changes in the expression of genes involved in paracrine communication. The formation of new communication hubs connecting CECs and LSECs included the hepatocyte growth factor (Hgf)/c-Met signaling pathway. In hepatocytes and tumor cells, YAP/TEA domain transcription factor 4 (TEAD4)–dependent transcriptional induction of osteopontin (Opn) stimulated c-Met expression in EC with CEC phenotype, which sensitized these cells to the promigratory effects of LSEC-derived Hgf. In human hepatocellular carcinoma, the presence of a migration-associated tip-cell signature correlated with poor clinical outcome and the loss of LSEC marker gene expression. The occurrence of c-MET–expressing CECs in human liver cancer samples was confirmed at the single-cell level. In summary, YAP-dependent changes of the liver vascular niche comprise the formation of heterologous communication hubs in which tumor cell–derived factors modify the cross-talk between LSECs and CECs via the HGF/c-MET axis. Significance: YAP-dependent changes of the liver vascular niche comprise the formation of heterologous communication hubs in which tumor cell-derived factors modify the cross-talk between EC subpopulations.
AgRP neurons control compulsive exercise and survival in an activity-based anorexia model
Authors: Maria Consolata Miletta, Onur Iyilikci, Marya Shanabrough, Matija Šestan-Peša, Allison Cammisa, Caroline J. Zeiss, Marcelo O. Dietrich, Tamas L. Horvath
Journal: Nature Metabolism (2020)
Effect of IBD medications on COVID-19 outcomes: results from an international registry
Authors: Ryan C Ungaro, Erica J Brenner, Richard B Gearry, Gilaad G Kaplan, Michele Kissous-Hunt, James D Lewis, Siew C Ng, Jean-Francois Rahier, Walter Reinisch, Flávio Steinwurz, Fox E Underwood, Xian Zhang, Jean-Frederic Colombel, Michael D Kappelman
Journal: Gut (2020)

We sought to evaluate COVID-19 clinical course in patients with IBD treated with different medication classes and combinations.
TCT CONNECT-47 Impact of Sex at Birth on Long-Term Cardiovascular Outcomes of Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndrome
Authors: Anastasios Roumeliotis, Bimmer Claessen, Samantha Sartori, Davide Cao, Hanbo Qiu, Anton Camaj, Rishi Chandiramani, Johny Nicolas, Ridhima Goel, Mauro Chiarito, Joseph Sweeny, George Dangas, Samin Sharma, Annapoorna Kini, Roxana Mehran
Journal: Journal of the American College of Cardiology (2020)
TCT CONNECT-352 Early Experience With a Novel Transfemoral Mitral Valve Implantation System in Complex Degenerative Mitral Regurgitation
Authors: Alberto Alperi, Francois Dagenais, David del Val, Mathieu Bernier, Torsten Vahl, Omar Khalique, Thomas Modine, Juan Granada, Josep Rodes-Cabau
Journal: Journal of the American College of Cardiology (2020)
Escape from abluminal LRP1-mediated clearance for boosted nanoparticle brain delivery and brain metastasis treatment
Authors: Naveed Ullah Khan, Jiang Ni, Xiufeng Ju, Tongtong Miao, Haiyan Chen, Liang Han
Journal: Acta Pharmaceutica Sinica B (2020)

Breast cancer brain metastases (BCBMs) are one of the most difficult malignancies to treat due to the intracranial location and multifocal growth. Chemotherapy and molecular targeted therapy are extremely ineffective for BCBMs due to the inept brain accumulation because of the formidable blood‒brain barrier (BBB). Accumulation studies prove that low density lipoprotein receptor-related protein 1 (LRP1) is promising target for BBB transcytosis. However, as the primary clearance receptor for amyloid beta and tissue plasminogen activator, LRP1 at abluminal side of BBB can clear LRP1-targeting therapeutics. Matrix metalloproteinase-1 (MMP1) is highly enriched in metastatic niche to promote growth of BCBMs. Herein, it is reported that nanoparticles (NPs-K-s-A) tethered with MMP1-sensitive fusion peptide containing HER2-targeting K and LRP1-targeting angiopep-2 (A), can surmount the BBB and escape LRP1-mediated clearance in metastatic niche. NPs-K-s-A revealed infinitely superior brain accumulation to angiopep-2-decorated NPs-A in BCBMs bearing mice, while comparable brain accumulation in normal mice. The delivered doxorubicin and lapatinib synergistically inhibit BCBMs growth and prolongs survival of mice bearing BCBMs. Due to the efficient BBB penetration, special and remarkable clearance escape, and facilitated therapeutic outcome, the fusion peptide-based drug delivery strategy may serve as a potential approach for clinical management of BCBMs.
SAT0148 Fibromyalgia syndrome characterised by patient-reported sleep, fatigue, mood and quality of life
Authors: AM Sesti, AE Corbin, C McLaughlin-Miley, M Jaffe, J Moore, JP Young, L LaMoreaux, U Sharma, M Versavel
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> Fibromyalgia (FM) is a chronic condition of pain, tender points and multiple associated symptoms. A diagnosis is made by the ACR 1990 criteria requiring a history of widespread pain and pain in 11 of 18 tender points. Although pain is required for a diagnosis, the associated symptoms contribute to the syndromatic nature of the condition. This trial included measures of sleep, fatigue, mood, QoL and pain. <h3>Objectives</h3> <h3>Methods</h3> 529 fibromyalgia patients per ACR criteria were assessed at baseline after discontinuing meds used for FM pain/insomnia (e.g. antidepressants, sedatives). The questionnaires were the Medical Outcomes Study Sleep Scale (MOS-SS), Multidimensional Assessment of Fatigue (MAF), Hospital Anxiety and Depression Scale (HADS) and SF-36. The MOS-SS has 12-items with an index score and 7 subscales: disturbance, snoring, awakening short of breath/headache (SOB/HA), adequacy, somnolence (range 0–100); quantity of sleep (reported hours); and, optimal sleep (% with 7–8 h). Higher scores on the MOS-SS indicate more of the measured domain. The MAF has 16 items and 1 global index score from items measuring severity, distress, impact on activities and frequency of fatigue (range 1–50). The HADS has 14-items for anxiety/depression ranging from 0–21. Higher MAF and HADS scores indicate greater impairment. The SF-36 has 8 subscales measuring general health status with higher scores indicating better health states. <h3>Results</h3> Demographics and pain scores are reported in the companion abstract by Corbin, <i>et al</i>. 2001. Baseline MOS-SS were: overall problems (62.3), disturbance (62.5), snoring (36.9), SOB/HA (36.1), adequacy (19.7), somnolence (49.5), quantity (5.6), and 21.7% reported optimal sleep. The fatigue index was 38.9 and the HADS scores were mild with anxiety (10.1) and depression (8.6). SF-36 scores were physical function (40.5), role physical (15.2), bodily pain (27.6), general health (47.5), vitality (20.4), social functioning (48.8), role-emotional (46.0) and mental health (58.7). <h3>Conclusion</h3> These data suggest that FM patients have impaired sleep and concomitant fatigue based on relatively high index scores. The predominant sleep problems were disrupted and inadequate sleep with a fair amount of somnolence. Patients reported low quality of life, particularly on domains of bodily pain, role physical, and vitality. Along with a high level of pain, impairments in sleep, fatigue and QoL were reported in this FM population.
TCT CONNECT-378 Sex Disparities Among Patients Undergoing Complex Percutaneous Coronary Intervention (PCI): Insights From a Single-Center Large-Volume PCI Registry
Authors: Johny Nicolas, Bimmer Claessen, Davide Cao, Mauro Chiarito, Samantha Sartori, Hanbo Qiu, Anastasios Roumeliotis, Ridhima Goel, Matteo Nardin, Birgit Vogel, Ali Turfah, Rishi Chandiramani, Zaha Waseem, Prathyusha Bande, Joseph Sweeny, Annapoorna Kini, Samin Sharma, George Dangas, Roxana Mehran
Journal: Journal of the American College of Cardiology (2020)
Roger Hanif Armour
Authors: Peter Kelly, Roger Hanif Armour
Journal: BMJ (2020)

Roger Hanif Armour (previously Ahmed) was a caring and compassionate man of great humility and of remarkable dedication and surgical skill. He was always a calming and reassuring presence who was admired by all who knew him from the most junior members of staff to his most senior colleagues. Everyone felt it a great privilege and a pleasure to have to worked for him.

As a medical student he was concerned by the children blinded by keratomalacia, which a few pennies worth of vitamins could have prevented. In his final year he held a fortnightly clinic in a poor part of Lahore, aided by an uncle in the Red Cross who supplied the medication. In …
SAT0137 Long-term observation of fibromyalgia patients
Authors: L Szczepanski, C Stepniak, B Targonska-Stepniak
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> <h3>Objectives</h3> The objective of the study was to evaluate the natural course of fibromyalgia syndrome (FS) and to reveal if FS was not only the mask of another somatic disease. <h3>Methods</h3> A questionnaire concerning the present health state was sent to 177 patients with FS diagnosed between 1991 and 1997. One hundred fifteen answers were received. Thirty three patients (28,7%) had no pain. In 19 (16,5%) cases the same intensity of pain and other subjective symptoms were noted. Majority of patients- 63 (54,8%) assessed their complaints as more intensive. Clinical and basic laboratory examinations were performed in 86 FS women, aged 39–70. They were asked about their present pain status, other complaints, mental status and their understanding of the matter of FS. Moreover, in all cases the FIQ answers were obtained. In some cases additional tests were performed (X-rays, Schrimer?s test, ANA, RF). <h3>Results</h3> At examination only 5 patients (5,8%) had no pain in musculoskeletal system and felt very well; in the remaining 81 patients the features of active FS were noted. 43 patients (50%) described the pain as ?awful” and ?terrible?, in 32 cases (37,2%) the pain was great or even insufferable. Less than 11 tender points (TPs) in 11 patients (12,8%), however in these patients other manifestations of FS were present (sleep disturbances, fatigue, ancillary symptoms). In the remaining 70 patients all ACR criteria for diagnosis of FS were still present. Four patients (4,7%) fulfilled criteria for diagnosis of Sjögren’s Syndrome (SS); ocular and oral dryness appeared later than widespread pain. There were no features of other connective tissue diseases in the remaining 82 patients. At examination other musculosceletal disorders were observed in some cases: gonarthrosis (4 patients- 4,7%), coxarthrosis (6 patients- 7%), carpal tunnel syndrome (21 patients- 24,4%), enthesopathy (15 patients- 17,4%). The majority of FS patients (61- 70,9%) still felt suspicion of severe somatic disease and were anxious about the future; 44 patients (51,2%) believed, that careful hospital examination is necessary. <h3>Conclusion</h3> FS remains active in most patients several years after the first diagnosis. The majority of patients feel poor or even worse, the remission of FS is uncommonly achieved and the results of treatment are still unsatisfactory. No serious chronic diseases were observed in those patients. The results confirm the high usefulness of ACR 1990 FS criteria in everyday clinical practice. In a few cases FS can be associated with subclinical course of SS.