tbuckley/cabot-search huggingface dataset:
TCT-140 Impact of Left Ventricular Mass Regression on Long-Term Clinical Outcomes After Transcatheter Aortic Valve Replacement: An Analysis of the PARTNER 1 and 2 Trials and Registries
Authors: Katherine Chau, Pamela Douglas, Philippe Pibarot, Rebecca Hahn, Omar Khalique, Wael Jaber, Paul Cremer, Neil Weissman, Federico Asch, Yiran Zhang, Zachary Gertz, Sammy Elmariah, Marie-Annick Clavel, Vinod Thourani, Melissa Daubert, Maria Alu, Martin Leon, Brian Lindman
Journal: Journal of the American College of Cardiology (2019)
Recent developments and highlights in drug hypersensitivity
Authors: Cristobalina Mayorga, Tahia D. Fernandez, Maria Isabel Montañez, Esther Moreno, María José Torres
Journal: Allergy (2019)

Drug hypersensitivity reactions (DHRs) are nowadays the third cause of allergy after rhinitis and asthma with a significant increase in prevalence in both adults and paediatric population with new drugs included as culprit. For this, DHRs represent not only a health problem but also a significant financial burden for affected individuals and health systems. Mislabelling DHRs is showing to be a relevant problem for both, false label of drug allergic and false label of nonallergic. All this reinforces the need to improve accurate diagnostic approaches that allow an appropriate management. Moreover, there is a need for training both, nonallergist stakeholders and patients to improve the reaction identification and therefore decrease the mislabelling. The use of allergy cards has shown to be relevant to avoid the induction of DHRs due to the prescription of wrong medication. Recent developments over the last 2 years and highlights about risk factors, diagnostic approaches, mechanisms involved as well as prevention actions, and management have been reviewed. In these papers, it has been outlined the need for correct diagnosis and de-labelling of patients previously false-reported as allergic, which will improve the management and treatment of patients with DHRs.
TCT-283 10-Year Clinical Outcomes From a Trial of 3 Limus-Eluting Stents With Different Polymer Coatings in Diabetic Patients With Coronary Artery Disease: Results From the ISAR-TEST 4 Randomized Trial
Authors: Sebastian Kufner, Tobias Lenz, Michael Joner, Salvatore Cassese, Erion Xhepa, Robert Byrne, Tareq Ibrahim, Karl-Ludwig Laugwitz, Adnan Kastrati
Journal: Journal of the American College of Cardiology (2019)
New HIV-1 circulating recombinant form 94: from phylogenetic detection of a large transmission cluster to prevention in the age of geosocial-networking apps in France, 2013 to 2017
Authors: Marc Wirden, Fabienne De Oliveira, Magali Bouvier-Alias, Sidonie Lambert-Niclot, Marie-Laure Chaix, Stéphanie Raymond, Ali Si-Mohammed, Chakib Alloui, Elisabeth André-Garnier, Pantxika Bellecave, Brice Malve, Audrey Mirand, Coralie Pallier, Jean-Dominique Poveda, Theresa Rabenja, Veronique Schneider, Anne Signori-Schmuck, Karl Stefic, Vincent Calvez, Diane Descamps, Jean-Christophe Plantier, Anne-Genevieve Marcelin, Benoit Visseaux
Journal: Eurosurveillance (2019)

Background Ending the HIV pandemic must involve new tools to rapidly identify and control local outbreaks and prevent the emergence of recombinant strains with epidemiological advantages. Aim This observational study aimed to investigate in France a cluster of HIV-1 cases related to a new circulating recombinant form (CRF). The confirmation this CRF’s novelty as well as measures to control its spread are presented. Methods Phylogenetic analyses of HIV sequences routinely generated for drug resistance genotyping before 2018 in French laboratories were employed to detect the transmission chain. The CRF involved was characterised by almost full-length viral sequencing for six cases. Cases’ clinical data were reviewed. Where possible, epidemiological information was collected with a questionnaire. Results The transmission cluster comprised 49 cases, mostly diagnosed in 2016–2017 (n = 37). All were infected with a new CRF, CRF94_cpx. The molecular proximity of this CRF to X4 strains and the high median viraemia, exceeding 5.0 log 10 copies/mL, at diagnosis, even in chronic infection, raise concerns of enhanced virulence. Overall, 41 cases were diagnosed in the Ile-de-France region and 45 were men who have sex with men. Among 24 cases with available information, 20 reported finding partners through a geosocial networking app. Prevention activities in the area and population affected were undertaken. Conclusion We advocate the systematic use of routinely generated HIV molecular data by a dedicated reactive network, to improve and accelerate targeted prevention interventions. Geosocial networking apps can play a role in the spread of outbreaks, but could also deliver local targeted preventive alerts.
TCT-832 Detection Ability of Optical Coherence Tomography for Cholesterol Crystal: Histopathological Validation Study
Authors: Yosuke Katayama, Atsushi Tanaka, Kosei Terada, Hiroki Emori, Mao Yokoyama, Masahiro Takahata, Teruaki Wada, Manabu Kashiwagi, Kunihiro Shimamura, Yasutsugu Shiono, Akio Kuroi, Yoshiki Matsuo, Takashi Kubo, Takeshi Hozumi, Toshikazu Kondo, Takashi Akasaka
Journal: Journal of the American College of Cardiology (2019)
Stress-Driven Transposable Element De-repression Dynamics and Virulence Evolution in a Fungal Pathogen
Authors: Simone Fouché, Thomas Badet, Ursula Oggenfuss, Clémence Plissonneau, Carolina Sardinha Francisco, Daniel Croll
Journal: Molecular Biology and Evolution (2019)

Transposable elements (TEs) are drivers of genome evolution and affect the expression landscape of the host genome. Stress is a major factor inducing TE activity; however, the regulatory mechanisms underlying de-repression are poorly understood. Plant pathogens are excellent models to dissect the impact of stress on TEs. The process of plant infection induces stress for the pathogen, and virulence factors (i.e., effectors) located in TE-rich regions become expressed. To dissect TE de-repression dynamics and contributions to virulence, we analyzed the TE expression landscape of four strains of the major wheat pathogen Zymoseptoria tritici. We experimentally exposed strains to nutrient starvation and host infection stress. Contrary to expectations, we show that the two distinct conditions induce the expression of different sets of TEs. In particular, the most highly expressed TEs, including miniature inverted-repeat transposable element and long terminal repeat-Gypsy element, show highly distinct de-repression across stress conditions. Both the genomic context of TEs and the genetic background stress (i.e., different strains harboring the same TEs) were major predictors of de-repression under stress. Gene expression profiles under stress varied significantly depending on the proximity to the closest TEs and genomic defenses against TEs were largely ineffective to prevent de-repression. Next, we analyzed the locus encoding the Avr3D1 effector. We show that the insertion and subsequent silencing of TEs in close proximity likely contributed to reduced expression and virulence on a specific wheat cultivar. The complexity of TE responsiveness to stress across genetic backgrounds and genomic locations demonstrates substantial intraspecific genetic variation to control TEs with consequences for virulence.
TCT-564 Long-Term Clinical Outcomes of Patients Undergoing Percutaneous Intervention of Transplanted Renal Artery Stenosis
Authors: Adriano Barbosa, Gustavo Feitosa, Henry Campos, Attilio Galhardo, Gabriel Kanhouche, Manoela Barteczko, Ana Faccinetto, Hélio Tedesco, José Osmar Pestana
Journal: Journal of the American College of Cardiology (2019)
A Novel Von Willebrand Factor Fragment Acts As a Chaperone to Prolong the Half-Life of Recombinant Human FVIII (Simoctocog Alfa) in Hemophilia a Dogs and FVIII/VWF Double Knockout Mice
Authors: Barbara A Solecka-Witulska, David Lillicrap, Christine Hough, Christoph Kannicht
Journal: Blood (2017)
TCT-35 Redo Transcatheter Aortic Valve Replacement for Structural and Nonstructural Transcatheter Valve Dysfunction: Initial Experience From a Single High-Volume Center
Authors: Lisa Crusius, Philipp Hartung, Philipp Lauten, Johannes Wilde, Thilo Noack, Philipp Kiefer, Marcus Sandri, Felix Woitek, Axel Linke, Steffen Desch, Michael Borger, Holger Thiele, David Holzhey, Mohamed Abdel-Wahab
Journal: Journal of the American College of Cardiology (2019)
Improving Communication in Heart Failure Patient Care
Authors: Nathan E. Goldstein, Harriet Mather, Karen McKendrick, Laura P. Gelfman, Mathew D. Hutchinson, Rachel Lampert, Hannah I. Lipman, Daniel D. Matlock, Jacob J. Strand, Keith M. Swetz, Jill Kalman, Jean S. Kutner, Sean Pinney, R. Sean Morrison
Journal: Journal of the American College of Cardiology (2019)
Generating the Blood Exposome Database Using a Comprehensive Text Mining and Database Fusion Approach
Authors: Dinesh Kumar Barupal, Oliver Fiehn
Journal: Environmental Health Perspectives (2019)

Background: Blood chemicals are routinely measured in clinical or preclinical research studies to diagnose diseases, assess risks in epidemiological research, or use metabolomic phenotyping in response to treatments. A vast volume of blood-related literature is available via the PubMed database for data mining. Objectives: We aimed to generate a comprehensive blood exposome database of endogenous and exogenous chemicals associated with the mammalian circulating system through text mining and database fusion. Methods: Using NCBI resources, we retrieved PubMed abstracts, PubChem chemical synonyms, and PMC supplementary tables. We then employed text mining and PubChem crowdsourcing to associate phrases relating to blood with PubChem chemicals. False positives were removed by a phrase pattern and a compound exclusion list. Results: A query to identify blood-related publications in the PubMed database yielded 1.1 million papers. Matching a total of 15 million synonyms from 6.5 million relevant PubChem chemicals against all blood-related publications yielded 37,514 chemicals and 851,999 publications records. Mapping PubChem compound identifiers to the PubMed database yielded 49,940 unique chemicals linked to 676,643 papers. Analysis of open-access metabolomics papers related to blood phrases in the PMC database yielded 4,039 unique compounds and 204 papers. Consolidating these three approaches summed up to a total of 41,474 achiral structures that were linked to 65,957 PubChem CIDs and to over 878,966 PubMed articles. We mapped these compounds to 50 databases such as those covering metabolites and pathways, governmental and toxicological databases, pharmacology resources, and bioassay repositories. In comparison, HMDB, the Human Metabolome Database, links 1,075 compounds to blood-related primary publications. Conclusion: This new Blood Exposome Database can be used for prioritizing chemicals for systematic reviews, developing target assays in exposome research, identifying compounds in untargeted mass spectrometry, and biological interpretation in metabolomics data. The database is available at http://bloodexposome.org. https://doi.org/10.1289/EHP4713
High Unintended Pregnancy Rate Spurs Efforts to Ease Contraceptive Access
Authors: Rita Rubin
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TCT-406 Clinical Impact of DAPT Cessation Within 12 Months of Drug-Eluting Stent Implantation in Caucasians and Minorities: Insights From the PLATINUM Diversity and PROMUS Element Plus Post-Approval Study
Authors: Davide Cao, Roxana Mehran, Anastasios Roumeliotis, Rishi Chandiramani, Moritz Blum, Ridhima Goel, Samantha Sartori, John Wang, Islam Othman, Henry Liberman, Dominic Allocco, Paul Underwood, Wayne Batchelor
Journal: Journal of the American College of Cardiology (2019)
TCT-305 Real-World Experience of Biodegradable-Polymer Drug Eluting Stents Versus Second-Generation Durable-Polymer Drug-Eluting Stents in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Authors: Hui Wen Sim, Elizabeth H.E. Thong, Joon Sin Ser, Jason Zhenfeng Chen, Mark Chan, Ronald Lee, Huay Cheem Tan, Adrian Low, Edgar Tay, Poay Huan Loh, Koo Hui Chan, Joshua Loh
Journal: Journal of the American College of Cardiology (2019)
Comprehensive Genomic Profiling of Chinese Acute Myeloid Leukemia (AML) with FLT3 ITD Using Ultra Deep Sequencing
Authors: Hui Kang, Chen Lijuan, Yubing Xu, Fanxiang Zeng, Huan Tong, Lihua Sun, Jinwei Hu, Yongqi Yue, Gung-wei Chirn, Kai Wang
Journal: Blood (2018)
Incidence and outcome of takotsubo syndrome compared to acute myocardial infarction, in men versus women
Authors: B. Björn Redfors, S. Jha, S. Tholeifsson, T. Jernberg, O. Angeras, Ole Fröbert, P. Petursson, P. Tornvall, G. Sarno, A. Ravn-Fischer, A. Lyon, S. James, D. Erlinge, E. Omerovic
Journal: European Journal of Heart Failure (2019)
Invasive Fungal Infection in the Setting of Peripheral Blood Non-Manipulated Haploidentical Stem Cell Transplantation with Postransplant Cyclophosphamide
Authors: Nieves Dorado, Gillen Oarbeascoa, Miguel Argüello, Pascual Balsalobre, David Serrano, Carolina Martínez-Laperche, Rebeca Bailén, Javier Anguita, Jose Luis Díez-Martín, Mi Kwon
Journal: Blood (2018)
TCT-717 Hemodynamic Predictors of Leaflet Thrombosis in Low Risk Patients Undergoing TAVR: A Sub Study of the Low Risk TAVR Trial
Authors: Jaffar Khan, Toby Rogers, Ron Waksman, Rebecca Torguson, Gaby Weissman, Diego Medvedofsky, Paige Craig, Cheng Zhang, Christian Shults, Hector Garcia-Garcia, Paul Kolm, Lowell Satler, Itsik Ben-Dor, Federico Asch
Journal: Journal of the American College of Cardiology (2019)
Evaluation of remission definitions for systemic lupus erythematosus: a prospective cohort study
Authors: Vera Golder, Rangi Kandane-Rathnayake, Molla Huq, Worawit Louthrenoo, Shue Fen Luo, Yeong-Jian Jan Wu, Aisha Lateef, Sargunan Sockalingam, Sandra V Navarra, Leonid Zamora, Laniyati Hamijoyo, Yasuhiro Katsumata, Masayoshi Harigai, Madelynn Chan, Sean O’Neill, Fiona Goldblatt, Chak Sing Lau, Zhan Guo Li, Alberta Hoi, Mandana Nikpour, Eric F Morand
Journal: The Lancet Rheumatology (2019)
TCT-306 Association Between Prediabetes and Clinical Outcomes After Left Main Coronary Artery Revascularization by PCI or CABG: Analysis From the EXCEL Trial
Authors: Bjorn Redfors, Shmuel Chen, Erick Schampaert, Imre Ungi, Samer Mansour, Manel Sabate, Anthony Gershlick, Andrzej Bochenek, Dimitri Karmpaliotis, Nicolas Noiseux, Aaron Crowley, Ori Ben-Yehuda, Gregg Stone
Journal: Journal of the American College of Cardiology (2019)
Genetic Prediction of Serum 25-Hydroxyvitamin D, Calcium, and Parathyroid Hormone Levels in Relation to Development of Type 2 Diabetes: A Mendelian Randomization Study
Authors: Shuai Yuan, Xia Jiang, Karl Michaëlsson, Susanna C. Larsson
Journal: Diabetes Care (2019)

OBJECTIVE We conducted a Mendelian randomization study to investigate the associations of genetically predicted serum 25-hydroxyvitamin D (S-25OHD), calcium (S-Ca), and parathyroid hormone (S-PTH) levels with type 2 diabetes (T2DM). RESEARCH DESIGN AND METHODS Seven, six, and five single nucleotide polymorphisms (SNPs) associated with S-25OHD, S-Ca, and S-PTH levels, respectively, were used as instrumental variables. Data on T2DM were available for 74,124 case subjects with T2DM and 824,006 control subjects. The inverse variance–weighted method was used for the primary analyses, and the weighted median and Mendelian randomization (MR)–Egger methods were used for supplementary analyses. RESULTS Genetically predicted S-25OHD but not S-Ca and S-PTH levels were associated with T2DM in the primary analyses. For 1 SD increment of S-25OHD levels, the odds ratio (OR) of T2DM was 0.94 (95% CI 0.88–0.99; P = 0.029) in an analysis based on all seven SNPs and 0.90 (95% CI 0.83–0.98; P = 0.011) in an analysis based on three SNPs within or near genes involved in vitamin D synthesis. Only the association based on the SNPs involved in vitamin D synthesis remained in the weighted median analysis, and no pleiotropy was detected (P = 0.153). Pleiotropy was detected in the analysis of S-Ca (P = 0.013). After correcting for this bias using MR-Egger regression, the OR of T2DM per 1 SD increment of S-Ca levels was 1.41 (95% CI 1.12–1.77; P = 0.003). CONCLUSIONS Modest lifelong higher S-25OHD levels were associated with reduced odds of T2DM, but the association was only robust for SNPs in the vitamin D synthesis pathway. The possible role of S-Ca levels for T2DM development requires further research.
A Reciprocal Interaction between Immune Reconstitution and Hemorrhagic Cystitis after Allogeneic Hematopoietic Stem Cell Transplantation
Authors: Min Xiao, Xiaofeng Luo, Jinhua Ren, Xiaozhu Yang, Haojie Zhu, Kangni Lin, Minmin Chen, Shaozhen Chen, Qian Li, Zhizhe Chen, Jianda Hu, Ting Yang
Journal: Blood (2018)
TCT-497 A Novel Risk Stratification System “Angiographic Grace Score” Is Useful for Predicting In-Hospital Mortality of Patients With Acute Myocardial Infarction～From the K-Active Registry
Authors: Takanobu Mitarai, Yasuhiro Tanabe, Yoshihiro Akashi, Maeda Atsuo, Junya Ako, Yuji Ikari, Toshiaki Ebina, Naoki Sato, Ichiro Michishita, Kazuo Kimura, Hiroshi Suzuki
Journal: Journal of the American College of Cardiology (2019)
TCT-656 National Utilization and Outcomes of Patients Undergoing Percutaneous Coronary Intervention With Intracoronary Imaging and Atherectomy
Authors: Fahed Darmoch, Homam Moussa Pacha, Yasser Al-Khadra, Mohamad Soud, M. Chadi Alraies
Journal: Journal of the American College of Cardiology (2019)
TCT-90 Electrosurgical LAceration and STAbilization of a MitraClip (ELASTA-Clip)
Authors: John Lisko, Adam Greenbaum, Jaffar Khan, Robert Guyton, Patrick Gleason, Samuel Maidman, Lucia Alvarez, Kendra Grubb, Norihiko Kamioka, Isida Byku, Chandan Devireddy, Toby Rogers, Vasilis Babaliaros
Journal: Journal of the American College of Cardiology (2019)
Becoming a Principal Investigator: Designing and Navigating Your Academic Adventure
Authors: Paul L. Greer, Melanie A. Samuel
Journal: Neuron (2019)

Starting your own academic lab is a wonderful opportunity to impact science through research and trainee mentoring. In this article, we share some thoughts and resources for this undertaking in the hope that they may enhance the experience of others. Starting your own academic lab is a wonderful opportunity to impact science through research and trainee mentoring. In this article, we share some thoughts and resources for this undertaking in the hope that they may enhance the experience of others.
TCT-99 Outcomes With Retrograde Versus Antegrade Chronic Total Occlusion Revascularization
Authors: Michael Megaly, Abdelrahman Ali, Marwan Saad, Mohamed Omer, Iosif Xenogiannis, Gerald Werner, Dimitrios Karmpaliotis, Juan Russo, Masahisa Yamane, Roberto Garbo, Imre Ungi, Stéphane Rinfret, Ashish Pershad, Santiago Garcia, Georgios Sianos, Kambis Mashayekhi, Alfredo Galassi, M. Nicholas Burke, Emmanouil Brilakis
Journal: Journal of the American College of Cardiology (2019)
TCT-500 Association Between Microvascular Dysfunction and Diastolic Dysfunction in ST-Segment Elevation Myocardial Infarction With Preserved Ejection Fraction
Authors: Min Gyu Kang, Jong-Hwa Ahn, Yongwhi Park, Young-Hoon Jeong, Jin-Sin Koh
Journal: Journal of the American College of Cardiology (2019)
Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization
Authors: Ana P. Gomes, Didem Ilter, Vivien Low, Adam Rosenzweig, Zih-Jie Shen, Tanya Schild, Martin A. Rivas, Ekrem E. Er, Dylan R. McNally, Anders P. Mutvei, Julie Han, Yi-Hung Ou, Paola Cavaliere, Edouard Mullarky, Michal Nagiec, Sejeong Shin, Sang-Oh Yoon, Noah Dephoure, Joan Massagué, Ari M. Melnick, Lewis C. Cantley, Jessica K. Tyler, John Blenis
Journal: Cancer Cell (2019)
Comparison of Survival After Mohs Micrographic Surgery vs Wide Margin Excision for Early-Stage Invasive Melanoma
Authors: Shayan Cheraghlou, Sean R. Christensen, George O. Agogo, Michael Girardi
Journal: JAMA Dermatology (2019)

Melanoma is among the most common malignant neoplasms in the United States, with 91 270 cases estimated to be diagnosed in 2018. Since 2012, Mohs micrographic surgery (MMS) has gained popularity in the treatment of melanoma in situ. Although current guidelines for invasive melanoma without nodal metastases recommend surgery with wide margin excision (WME), use of MMS for this disease has increased as well, particularly in early stages. How the survival outcomes after each procedure compare with one another for early-stage invasive melanoma is unknown to date.To evaluate overall survival of patients with stage I melanoma defined by the American Joint Committee on Cancer Cancer Staging Manual, 8th edition (AJCC-8) after MMS vs traditional WME.This retrospective cohort study includes all patients with AJCC-8 stage I melanoma who underwent MMS or WME in the National Cancer Database with a diagnosis from January 1, 2004, through December 31, 2014. The National Cancer Database includes all reportable cases from Commission on Cancer-accredited facilities and represents approximately 50% of all newly diagnosed melanoma cases in the United States. Data were analyzed from November 13, 2018, through June 9, 2019.MMS vs WME.Overall survival evaluated using multivariable Cox proportional hazards regression analysis.A total of 70 319 eligible patients (52.3% male and 47.7% female; median [SD] age, 57.0 [16.2] years) were identified, including 67 085 treated with WME and 3234 treated with MMS. Multivariable Cox proportional hazards regression survival analysis controlling for clinical and tumor factors revealed that treatment with MMS was associated with a modest improvement in overall survival relative to WME (hazard ratio [HR], 0.86; 95% CI, 0.76-0.97). Propensity score-matched analysis of cohorts of patients treated with MMS vs WME also found modestly improved survival for those treated with MMS (HR, 0.82; 95% CI, 0.68-0.98). Academic facilities were more likely to use MMS than nonacademic facilities (odds ratio, 2.03; 95% CI, 1.88-2.18).These findings suggest that Mohs surgery may provide an alternative approach to traditional WME for appropriately selected cases of AJCC-8 stage I melanoma without compromising patient survival.