tbuckley/cabot-search huggingface dataset:
A standardization approach to compare treatment safety and effectiveness outcomes between clinical trials and real‐world populations in psoriasis
Authors: Z.Z.N. Yiu, K.J. Mason, J.N.W.N. Barker, P.J. Hampton, K. McElhone, C.H. Smith, R.B. Warren, C.E.M. Griffiths, M. Lunt, A.D. Burden
Journal: British Journal of Dermatology (2019)

Patients recruited in randomized controlled trials (RCTs) for biologic therapies in psoriasis are not fully representative of the real‐world psoriasis population. Firstly, to investigate whether patient characteristics are associated with being included in a psoriasis RCT. Secondly, to estimate the differences in the incidence of severe adverse events (SAEs) and the response rate between RCT and real‐world populations of patients on biologic therapies for psoriasis using a standardization method. Data from the British Association of Dermatologists Biologics and Immunomodulators Register (BADBIR) were appended to individual participant‐level data from two RCTs assessing ustekinumab in patients with psoriasis. Baseline variables were assessed for association of being in an RCT using a multivariable logistic regression model. Propensity score weights were derived to reweigh the registry population so that variables had the distribution of the trial population. We measured the C‐statistic of the model with trial status as the dependent variable, and the risk differences in the incidence rate of SAEs in the first year and Psoriasis Area and Severity Index (PASI) after 6 months in the BADBIR cohort before and after weighting. In total 6790 registry and 2021 RCT participants were included. The multivariable logistic regression model had a C‐statistic of 0.82 [95% confidence interval (CI) 0.81–0.83]. The risk differences for the incidence rate of SAEs and the proportion of patients with PASI < 1.5 were 9.27 (95% CI −3.91–22.5) per 1000 person‐years and 0.95 (95% CI −1.98–4.15), respectively. Our results suggest that RCTs of biologic therapies in patients with psoriasis are not fully representative of the real‐world population, but this lack of external validity does not account for the efficacy–effectiveness gap. What's already known about this topic? Patients with psoriasis who would not be eligible for randomized controlled trials (RCTs) investigating biologic therapies have a greater risk of serious adverse events and lower treatment effectiveness than patients who would have been eligible. What does this study add? Baseline patient characteristics were shown to be predictive of whether a patient would have been eligible for enrolment in an RCT for psoriasis biologic therapy. We did not find any efficacy–effectiveness gap between the sample representative of the real‐world population of patients with psoriasis and the sample representative of the RCT population. Factors outside of baseline patient characteristics, such as observer effect and higher adherence in RCTs, may be more influential in any efficacy–effectiveness gap between trial and real‐world populations of patients with psoriasis.
SYSTEMATIC REVIEW WITH NETWORK META-ANALYSIS: COMPARATIVE EFFICACY AND SAFETY OF FIXED DOSE COMBINATIONS OF ANGIOTENSIN II RECEPTOR BLOCKERS AND AMLODIPINE IN ASIAN HYPERTENSION PATIENTS
Authors: Mira Jung, Jong-Won Ha, Dae-Wook Lee, Philippe Pinton, Hye-Won Wang
Journal: Journal of the American College of Cardiology (2019)
Abstract 312: Cardiomyocyte-secreted Signaling Factors Modulate Adipocyte Differentiation And Function
Authors: Kenneth S Gresham, Walter J Koch
Journal: Circulation Research (2018)

Heart failure (HF) alters cardiomyocyte metabolism by altering energy substrate utilization and mitochondrial function, which has potential implications for global metabolic health. Recent studies demonstrated that cardiomyocyte-released signaling factors communicate with peripheral organ systems to alter metabolic function and that signaling pathways activated by HF control the release of these factors. However, the identity of these factors is still under investigation. Conditioned media (CM) collected from neonatal rat ventricular myocytes (NRVMs) was used to treat 3T3-L1 pre-adipocytes to 1) identify signaling molecules released by cardiomyocytes that could regulate global metabolic function and 2) determine how HF signaling pathways alter their release. NRVM-CM slowed adipocyte differentiation as measured by lipid accumulation using the fluorescent probe BODIPY 493/503 (57±8% decrease in normalized fluorescence compared to control media) and reduced the expression of adipocyte-related proteins. NRVM CM treatment also increased basal mitochondrial oxygen consumption (78 ± 3 vs 62±4 pmol/min) and maximal respiration (270±12 vs 220 ± 16 pmol/min) in mature adipocytes. CM protein fractionation revealed that released-factor activity was retained in &gt;100kDa fractions and this activity was abolished by trypsin digestion, suggesting a novel, high-MW cardiomyocyte-released signaling protein that targets adipocytes. To determine if NRVM-released factor activity is altered by HF signaling, the ability of G-protein kinase 2 (GRK2, upregulated by HF) signaling activity to alter NRVM-released factor activity was investigated. GRK2 overexpression in NRVMs increased the activity of this released-factor as measured by further decreased 3T3-L1 differentiation (lipid accumulation measured by BODIPY fluorescence was 70±8% compared to CM from GFP-overexpressing NRVMs), while overexpression of the GRK2 inhibitor βARKct increased adipocyte differentiation (140±13% compared to control NRVM-CM). These results suggest a novel, high-MW cardiomyocyte-released signaling protein under the control of HF signaling pathways communicates with adipocytes to alter adipose tissue function and potentially alter global metabolic function.
Effectiveness and Safety of the 15 Mg Dose of Rivaroxaban Compared with Vitamin k Antagonists in Patients with Atrial Fibrillation: Results from a Cohort Study in the Nationwide French Claims and Hospitalization Database (SNIIRAM)
Authors: Laurent Fauchier, Patrick Blin, Frédéric Sacher, Caroline Dureau-Pournin, Marie-Agnes Bernard, Regis Lassalle, Cécile Droz-Perroteau, Jean Dallongeville, Nicholas Moore
Journal: Blood (2017)
PREDICTING THE LOCATION AND MMORPHOLOGY OF CHRONIC TOTAL OCCLUSION PROXIMAL CAP USING INTRAVASCULAR ULTRASOUND IMAGING FROM A SIDE BRANCH
Authors: Yongzhen Fan, Gary Mintz, Masahiko Noguchi, Mingyou Zhang, Myong Hwa Yamamoto, Mitsuaki Matsumura, Dimitrios Karmpaliotis, He Huang, Akiko Maehara
Journal: Journal of the American College of Cardiology (2019)
THE ASSOCIATION OF LEFT VENTRICULAR FILLING, LEFT ATRIAL DYNAMICS, AND STIFFNESS WITH RIGHT VENTRICULAR TO PULMONARY CIRCULATION UNCOUPLING DURING EXERCISE IN PATIENTS WITH LEFT HEART DISEASE
Authors: Tadafumi Sugimoto, Francesco Bandera, Sara Boveri, Greta Generati, Eleonora Alfonzetti, Valentina Labate, Marco Guazzi
Journal: Journal of the American College of Cardiology (2019)
CHARACTERIZATION OF THE CHANGES IN CARDIAC STRUCTURE AND FUNCTION FOLLOWING PHOTON RADIATION THERAPY FOR BREAST CANCER USING SERIAL CARDIAC MAGNETIC IMAGING
Authors: Magid Awadalla, Malek Z.O. Hassan, Thiago F. de Souza, Raza M. Alvi, Nathaniel Mercaldo, Dahlia Banerji, Adam Rokicki, Rachel Jimenez, Florence Keane, Thiago Q.A.C. Silva, Felipe O. Costa, Licio Velloso, Wilson Nadruz, Fabricio Brenelli, Andrei C. Sposito, Jose R. Matos-Souza, Michael Jerosch-Herold, Otavio R. Coelho-Filho, Tomas G. Neilan
Journal: Journal of the American College of Cardiology (2019)
PROGNOSTIC VALUE OF PCSK9 AND LP(A) IN STABLE CORONARY ARTERY DISEASE
Authors: Alvaro Aceña, Cristina Álvarez de Toledo, Ana Maria Pello, Nieves Tarín, Carmen Cristobal, Ana Huelmos, Carlos Gutierrez Landaluce, Marta Lopez Castillo, Oscar Lorenzo, Maria Luisa Martin Mariscal, Juan Martinez Milla, Oscar Gonzalez Lorenzo, Ignacio Hernandez Gonzalez, Jose Tuñon Fernandez
Journal: Journal of the American College of Cardiology (2019)
Abstract P5-04-09: Not presented
Authors: H Mo, X Wang, Z Qian, B Xu, F Ma
Journal: Cancer Research (2019)

Abstract This abstract was not presented at the conference. Citation Format: Mo H, Wang X, Qian Z, Xu B, Ma F. Not presented [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr P5-04-09.
Abstract O.03: Monitoring the Occurrence of Kawasaki Syndrome in the United States
Authors: Ryan A Maddox, Marissa K Person, Lindsay J Joseph, Dana L Haberling, Claudia A Steiner, Lawrence B Schonberger, Ermias D Belay
Journal: Circulation (2015)

Objectives: To describe the occurrence of Kawasaki syndrome (KS) in the United States. Methods: The Kids’ Inpatient Database (KID; 2003, 2006, 2009, 2012) and the Nationwide Inpatient Sample (NIS; 2001-2011) were analyzed to determine KS-associated hospitalization rates and trends; the United States Centers for Disease Control and Prevention (CDC; 2010-July 2014) passive KS surveillance database was analyzed to assess the frequency of coronary artery abnormalities (CAAs) among reported KS cases meeting the CDC KS case definition. Results: The KS-associated hospitalization rate for children &lt;5 years of age using the KID was 18.1 (95% CI: 16.0-20.2) per 100,000 children in 2012, 20.0 (95% CI: 17.8-22.2) in 2009, 21.3 (95% CI: 18.9-23.7) in 2006, and 19.7 (95% CI: 17.7-21.7) in 2003. The 2012 KS-associated hospitalization rate was 21.0 (95% CI: 18.6-23.4) among males &lt;5 years of age and 15.0 (95% CI: 13.0-17.0) among females. Asians/Pacific Islanders had the highest rate among all racial groups, 29.8 (95% CI: 22.2-37.4). The average annual KS-associated hospitalization rate for children &lt;5 years of age using the NIS was constant from 2001-2011 at 18.8 per 100,000 per year (95% CI: 17.3-20.3; p=0.16) with peaks in 2005 (27.0 per 100,000; 95% CI: 19.3-34.7) and, to a lesser extent, in 2010 (22.6 per 100,000; 95% CI: 16.6-28.5). The CDC surveillance database included 497 physician-diagnosed KS cases &lt;18 years of age reported with onset occurring January 1, 2010 through July 31, 2014; about three-quarters (n=372) of the cases met the CDC KS case definition. Among KS cases meeting this definition that also contained complication data, 18.7% (69/369) had CAAs reported; among Asian/Pacific Islander children, 24.7% (18/73) had CAAs reported. Almost all KS cases in the database (98.1%, 363/370) were treated with intravenous immunoglobulin. Conclusions: Analyses of KID and NIS data did not indicate any increase in KS-associated hospitalization rates for children &lt;5 years of age in the United States through 2012. CAAs continue to occur at a comparable rate with past reports.
A Legionella pneumophila Kinase Phosphorylates the Hsp70 Chaperone Family to Inhibit Eukaryotic Protein Synthesis
Authors: Steven M. Moss, Isabelle R. Taylor, Davide Ruggero, Jason E. Gestwicki, Kevan M. Shokat, Shaeri Mukherjee
Journal: Cell Host & Microbe (2019)
TRENDS AND PREDICTORS OF 30-DAY READMISSION AMONG PATIENTS WITH INFECTIVE ENDOCARDITIS IN THE UNITED STATES FROM 2010 TO 2014
Authors: Deepak Kumar Pasupula, Anusha Bhat, Sudeep Siddappa Malleshappa, Amir Lotfi, Mara Slawsky, Samir Saba
Journal: Journal of the American College of Cardiology (2019)
PROGNOSTIC IMPLICATIONS OF DISCHARGE PATTERNS AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Satya Shreenivas, Scott Lilly, Susheel Kodali, Vinod Thourani, Michael Mack, David Cohen, Suzanne Arnold, Yiran Zhang, Maria Alu, Martin Leon, Dean Kereiakes
Journal: Journal of the American College of Cardiology (2019)
Transient epidermal barrier deficiency and lowered allergic threshold in filaggrin‐hornerin (<i>FlgHrnr</i><sup>−/−</sup>) double‐deficient mice
Authors: Sebastian Rahrig, Judith M. Dettmann, Birka Brauns, Verena N. Lorenz, Timo Buhl, Sanja Kezic, Peter M. Elias, Stephan Weidinger, Martin Mempel, Michael P. Schön, Andrea Braun
Journal: Allergy (2019)

Abstract Background Filaggrin (Flg) and hornerin (Hrnr) share similar structural and functional features. Both proteins have been implicated as essential proteins for skin barrier maintenance. Loss‐of‐function mutations of these genes constitute a risk factor for atopic dermatitis and eczema‐related asthma. Furthermore, both FLG and HRNR protein levels are downregulated in patients with atopic dermatitis. Thus, mice deficient for Flg and Hrnr provide a novel model to study skin barrier impairment and the susceptibility for cutaneous inflammation. Methods By using appropriate targeting vectors and breeding strategies, we established a homozygous FlgHrnr double‐deficient ( FlgHrnr −/− ) mouse model lacking both genes including the intergenomic sequence. Results Neonates appeared normal, but developed a transient scaly phenotype with overall flaky appearance, but no overt skin phenotype in adulthood, thereby reflecting a subclinical barrier defect seen in humans. Structurally, FlgHrnr −/− mice displayed a markedly reduced granular layer and a condensed cornified layer. Functionally, FlgHrnr −/− mice showed permeability abnormalities and metabolic aberrations regarding the production of natural moisturizing factors (NMFs) in the stratum corneum . Surprisingly, although the immune system revealed no aberrations under steady‐state conditions, FlgHrnr −/− mice are predisposed to mount an allergic contact dermatitis, especially at hapten threshold levels eliciting allergic reactions. Conclusions Together, our FlgHrnr −/− mouse model nicely reflects the epicutaneous sensitization susceptibilities and inflammatory reactions to environmental insults in humans with impaired skin barrier functions.
IMPACT OF ADVANCED AGE AND CHARLSON COMORBIDITY INDEX ON IN-HOSPITAL OUTCOMES IN SURGICAL AND TRANSCATHETER MITRAL VALVE REPAIR
Authors: Sanjay Venkatesh, Hanumantha Rao Jogu, Sameer Arora, Paula D. Strassle, Chinmay Patel, Cassandra Ramm, Michael Yeung, John Vavalle
Journal: Journal of the American College of Cardiology (2019)
DUCHENNE AND BECKER MUSCULAR DYSTROPHY CARRIERS: EVIDENCE OF CARDIOMYOPATHY BY EXERCISE AND CARDIAC MAGNETIC RESONANCE IMAGING
Authors: May Ling Mah, Linda Cripe, Michelle Slawinski, Eric Camino, Samiah Al-Zaidy, Kelly Lehman, Jamie Jackson, Jerry Mendell, Kan Hor
Journal: Journal of the American College of Cardiology (2019)
A RARE CASE OF HODGKIN'S LYMPHOMA PRESENTING WITH SUPERIOR VENA SYNDROME AND FUNCTIONAL PULMONIC STENOSIS
Authors: Fatimah Oluwakemi Bello, Gopal Katkoria, Cesar Gutierrez, Aramide Tijani, Arturo Suplee Rivera, Cyntiha Rivas Pajuelo, Meera Soni, Jose Lozano-Garcia
Journal: Journal of the American College of Cardiology (2019)
Abstract 310: Mechanistic Insights into Duchenne Muscular Dystrophy-Associated Cardiomyopathy
Authors: Tara Tassin, Jian Huang, Terry Gemelli, Mohammed Kanchwala, Lisa M Punnen, Emily Chung, Dylan Rivas, Sean Goetsch, Juan A Daniel, John Shelton, James A Richardson, Jay Schneider, Chao Xing, Sarvjeet Singh, Pradeep P Mammen
Journal: Circulation Research (2018)

Duchenne muscular dystrophy (DMD) is an X-linked neuromuscular disorder resulting from a mutation in the dystrophin gene. Loss of dystrophin function leads to progressive muscle wasting and cardiomyopathy. In 2018, advanced cardiomyopathy is the primary mode of death, despite the application of standard of care CHF therapies. Our group has recently undertaken a cardiac MRI study demonstrating that adult DMD patients have small hearts with very low LV mass as compared to patients with non-ischemic cardiomyopathy or healthy patients. The central hypothesis is DMD-associated cardiomyopathy develops secondary to dysregulation of various cardiac signaling pathways that modulate cardiac growth, namely cardiomyocyte proliferation. Utilizing the mdx mouse, a model of DMD, decreased heart/body weight ratios were noted from birth (P1: Hrt/BW 5.6 ± 0.16 vs. 4.8 ± 0.18 NTg vs mdx p&lt;0.005 n=32). NTg and m dx hearts have similar cardiomyocyte cell size (WGA staining: 0.08 ± 0.001 vs 0.08 ± 0.002 NTg vs mdx p&lt;0.05 n=3), suggesting there are fewer cells in mdx hearts. FACS analysis indicated mdx hearts have fewer cardiomyocytes than NTg hearts (35% reduction; 51.7e 4 ± 4.9e 4 vs. 33.8e 4 ± 3.5e 4 NTg vs mdx p&lt;0.05 n=6). Transcriptome profiling demonstrated that molecular pathways governing cardiac proliferation were significantly reduced in mdx hearts (Ki67: 4.8 ± 0.3 vs 2.0 ± 0.1 NTg vs mdx p&lt;0.005 n=3), with a corresponding increase in cardiac atrophy gene expression at later time points (Foxo3 1.4 ± 0.2 vs 2.8 ± 0.3 NTg vs mdx p&lt;0.005 n=3). Furthermore, immunohistochemical analyses showed significantly reduced proliferation in mdx hearts (Ki67: 13.7 ± 1.2 vs. 6.0 ± 1.0 NTg vs mdx p&lt;0.005, n=3; pH3: 118 ± 5.3 vs 59 ± 4.5 p&lt;0.005 n=3). Finally, RNA-Seq data revealed a disruption of the YAP signaling pathway, an important mediator of cardiomyocyte proliferation, in mdx P4 hearts. Cell cycle targets of YAP were reduced in P4 mdx hearts (20/27 genes, n=3) suggesting a disruption of the Hippo-Yap pathways in mdx hearts. Collectively, the current study provides a unique insight into the mechanism leading to the development DMD cardiomyopathy and directs investigation into potential therapeutic targets for the amelioration of DMD-associated cardiomyopathy.
TRANSIENT ISCHEMIC DILATATION IS INDEPENDENTLY ASSOCIATED WITH INCREASED CARDIOVASCULAR EVENTS IN PATIENTS WITHOUT ISCHEMIA: ANALYSIS OF THE REFINE REGISTRY
Authors: Robert J.H. Miller, Lien-Hsin Hu, Heidi Gransar, Julian Betancur, Evann Eisenberg, Tali Sharir, Matthews Fish, Terrence Ruddy, Sharmila Dorbala, Marcelo Di Carli, Andrew Einstein, Philipp A. Kaufmann, Albert Sinusas, Edward Miller, Timothy Bateman, Balaji Tamarappoo, Damini Dey, Daniel Berman, Piotr Slomka
Journal: Journal of the American College of Cardiology (2019)
LEFT VENTRICULAR MASS INDEX IMPROVES RISK ASSESSMENT OVER THE POOLED COHORT EQUATION (PCE) OR CORONARY ARTERY CALCIUM (CAC) SCORE IN THE INTERMEDIATE RISK POPULATION
Authors: Emmanuel Akintoye, Alexander Egbe, Oluwole Adegbala, Georgios Christodoulidis, Alexandros Briasoulis, Luis Afonso
Journal: Journal of the American College of Cardiology (2019)
PROGNOSTIC VALUE OF UNRECOGNIZED MYOCARDIAL INFARCTION DETECTED BY CARDIAC MAGNETIC RESONANCE IMAGING IN PATIENTS PRESENTING WITH FIRST ACUTE MYOCARDIAL INFARCTION
Authors: Yoshihisa Kanaji, Akinori Sugano, Masahiro Hoshino, Masao Yamaguchi, Masahiro Hada, Yohei Sumino, Hiroaki Ohya, Yoshinori Kanno, Haruhito Yuki, Hidenori Hirano, Tomoki Horie, Taishi Yonetsu, Tsunekazu Kakuta
Journal: Journal of the American College of Cardiology (2019)
TURBO-POWER LASER ATHERECTOMY COMBINED WITH DRUG-COATED BALLOON ANGIOPLASTY IS ASSOCIATED WITH IMPROVED ONE-YEAR OUTCOMES FOR THE TREATMENT OF COMPLEX FEMOROPOPLITEAL IN-STENT RESTENOSIS
Authors: Omar Jawaid, Damianos Kokkinidis, Prio Hossain, Bejan Alvandi, T. Foley, Gagan Singh, Stephen Waldo, John Laird, Ehrin Armstrong
Journal: Journal of the American College of Cardiology (2019)
Poor accordance to a DASH dietary pattern is associated with higher risk of ESRD among adults with moderate chronic kidney disease and hypertension
Authors: Tanushree Banerjee, Deidra C. Crews, Delphine S. Tuot, Meda E. Pavkov, Nilka Rios Burrows, Austin G. Stack, Rajiv Saran, Jennifer Bragg-Gresham, Neil R. Powe, Neil Powe, Tanushree Banerjee, Delphine Tuot, Chi-yuan Hsu, Charles McCulloch, Deidra Crews, Raymond Hsu, Vanessa Grubbs, Kirsten Bibbins-Domingo, Michael Shlipak, Carmen Peralta, Anna Rubinsky, Josef Coresh, Rajiv Saran, Vahakn Shahinian, Brenda Gillespie, Hal Morgenstern, Michael Heung, William Herman, William McClellan, Jennifer Bragg-Gresham, Diane Steffick, Anca Tilea, Maggie Yin, Ian Robinson, Kara Zivin, Vivian Kurtz, April Wyncott, Nilka Ríos Burrows, Mark Eberhardt, Linda Geiss, Juanita Mondesire, Bernice Moore, Priti Patel, Meda Pavkov, Deborah Rolka, Sharon Saydah, Sundar Shrestha, Larry Waller
Journal: Kidney International (2019)
FEASIBILITY OF REPEAT TRANSCATHETER AORTIC VALVE REPLACEMENT (TAVR) AFTER SAPIEN 3 TAVR (TAV-IN-TAV): A PILOT ANGIOGRAPHIC STUDY
Authors: Gilbert Hin-Lung Tang, Nish Patel, Eisha Gupta, Syed Zaid, Hasan Ahmad, Asaad Khan, Jason Kovacic, Cenap Undemir, Joshua B. Goldberg, Muhammad Khan, Steven Lansman, George Dangas, Samin Sharma, Annapoorna Kini
Journal: Journal of the American College of Cardiology (2019)
MYOCARDIAL INJURY ASSESSED BY MAGNETIC RESONANCE IMAGING IN ST-ELEVATION MYOCARDIAL INFARCTION PATIENTS UNDERGOING PRIMARY PERCUTANEOUS CORONARY INTERVENTION OR PHARMACOINVASIVE STRATEGY
Authors: Ricardo Pohls Vazquez, Alejandro Cabello Lopez, Rodrigo Gopar-Nieto, Abraham Villalobos Flores, Luis Augusto Baeza Herrera, Manuel Martinez Ramos, Grecia Iveth Maryelis Raymundo Martinez, Arturo Ivan Alonso Vazquez, Gabriela Paola Alanis Estrada, Jorge Luis Vargas Estrada, Diestefano Elliott Ronquillo Ramirez, Itzel Viridiana Delgado Cruz, Laura Torres-Araujo, Arnoldo Loaisiga, Pablo Martinez Amezcua, Alexandra Arias-Mendoza, Diego Araiza Garaygordobil
Journal: Journal of the American College of Cardiology (2019)
EVALUATION OF PATIENTS WITH AORTIC STENOSIS AND LEFT VENTRICULAR DYSFUNCTION CANDIDATES FOR TAVI: THE ROLE OF LEFT VENTRICULAR WALL STRESS IN PREDICTING THE RECOVERY OF CONTRACTILITY
Authors: Fabio Infusino, Simone Calcagno, Mariateresa Pucci, Paolo Severino, Viviana Maestrini, Nicolò Salvi, Massimo Mancone, Gennaro Sardella, Francesco Fedele
Journal: Journal of the American College of Cardiology (2019)
TELEMEDICINE AVOIDS UNNECESSARY TRANSFER OF AMI PATIENTS
Authors: Sameer Mehta, Roberto Botelho, Jamil Cade, Mario Alberto Torres, Daniel Vieira, Gladys Pinto, Maria Isabel Acosta, Claudia Lopez, Jorge Mazinni, Sushant Sunkaraneni, Alejandra Frauenfelder, Cristina Matheus, Lorena Pisana, Mariana Rubini Ceschim, Anibal Munguia, Maria Angelica Marin
Journal: Journal of the American College of Cardiology (2019)