Randomized Trial of Warfarin Nomograms
Authors: Gregory M. Peterson, Shane L. Jackson
Journal: Annals of Internal Medicine (2004)

Letters16 March 2004Randomized Trial of Warfarin NomogramsGregory M. Peterson, PhD, MBA and Shane L. Jackson, BPharm(Hons)Gregory M. Peterson, PhD, MBAFrom University of Tasmania, Hobart, Tasmania 7001, Australia.Search for more papers by this author and Shane L. Jackson, BPharm(Hons)From University of Tasmania, Hobart, Tasmania 7001, Australia.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-6-200403160-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read with interest the article by Kovacs and colleagues (1) comparing warfarin initiation nomograms in a select group of patients. The authors stated that their results “convincingly demonstrate that a nomogram based on a 10-mg starting dose is more effective than a 5-mg nomogram for outpatient treatment of acute venous thromboembolism.” We believe the authors have overstated the superiority of the 10-mg loading regimen of warfarin and that caution is required in applying their results in practice. Why expose patients to an increased risk for bleeding to reduce the time taken to reach a therapeutic international ...References1. Kovacs MJ, Rodger M, Anderson DR, Morrow B, Kells G, Kovacs J, et al . Comparison of 10-mg and 5-mg warfarin initiation nomograms together with low-molecular-weight heparin for outpatient treatment of acute venous thromboembolism. A randomized, double-blind, controlled trial. Ann Intern Med. 2003;138:714-9. [PMID: 12729425] LinkGoogle Scholar2. Crowther MA, Ginsberg JB, Kearon C, Harrison L, Johnson J, Massicotte MP, et al . A randomized trial comparing 5-mg and 10-mg warfarin loading doses. Arch Intern Med. 1999;159:46-8. [PMID: 9892329] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Gregory M. Peterson, PhD, MBA; Shane L. Jackson, BPharm(Hons)Affiliations: From University of Tasmania, Hobart, Tasmania 7001, Australia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoComparison of 10-mg and 5-mg Warfarin Initiation Nomograms Together with Low-Molecular-Weight Heparin for Outpatient Treatment of Acute Venous Thromboembolism Michael J. Kovacs , Marc Rodger , David R. Anderson , Beverly Morrow , Gertrude Kells , Judy Kovacs , Eleanor Boyle , and Philip S. Wells Randomized Trial of Warfarin Nomograms Richard White and William Dager Randomized Trial of Warfarin Nomograms Robert Zeller Randomized Trial of Warfarin Nomograms Brian F. Gage Randomized Trial of Warfarin Nomograms Robert J. DiDomenico Randomized Trial of Warfarin Nomograms Mark A. Crowther , Linda Harrison , and Jack Hirsh Randomized Trial of Warfarin Nomograms Theodore E. Warkentin Randomized Trial of Warfarin Nomograms Kenneth L. McCall Randomized Trial of Warfarin Nomograms Michael J. Kovacs and Philip S. Wells Metrics Cited byA 10 mg warfarin initiation nomogram is safe and effective in outpatients starting oral anticoagulant therapy for venous thromboembolismWarfarin Maintenance Dosing Patterns in Clinical Practice 16 March 2004Volume 140, Issue 6 Page: 488 Keywords Hemorrhage International normalized ratio Outpatients Randomized trials Venous thromboembolism ePublished: 16 March 2004 Issue Published: 16 March 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...