tbuckley/cabot-search huggingface dataset:
Confronting the Rise and Fall of US Life Expectancy
Authors: Howard K. Koh, Anand K. Parekh, John J. Park
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Randomized multicenter trial of sirolimus vs prednisone as initial therapy for standard-risk acute GVHD: the BMT CTN 1501 trial
Authors: Joseph Pidala, Mehdi Hamadani, Peter Dawson, Michael Martens, Amin M. Alousi, Madan Jagasia, Yvonne A. Efebera, Saurabh Chhabra, Iskra Pusic, Shernan G. Holtan, James L. M. Ferrara, John E. Levine, Marco Mielcarek, Claudio Anasetti, Joseph H. Antin, Javier Bolaños-Meade, Alan Howard, Brent R. Logan, Eric S. Leifer, Theresa S. Pritchard, Mary M. Horowitz, Margaret L. MacMillan
Journal: Blood (2019)
Immunodeficiency Caused Byheterozygous RAG1 Gene Mutation in a Boy Manifested As Severe Granulomatous Diseases and Eosinophilia: A Case Report
Authors: Jing Pan, Min Xiong, Jingjing Wang, Shan Wang, Zhuojun Ling, Jinlong Xu, Jiajia Duan, Gen Wang, Tong Wu, Chunrong Tong
Journal: Blood (2017)
A Phase 1b Study of Glasdegib in Combination with Azacitidine in Patients with Untreated Higher-Risk Myelodysplastic Syndromes, Acute Myeloid Leukemia, and Chronic Myelomonocytic Leukemia
Authors: Mikkael A. Sekeres, Michael W. Schuster, Magalie Joris, Jürgen Krauter, Johan A. Maertens, Emmanuel Gyan, Tibor Kovacsovics, Amit Verma, Paresh Vyas, Eunice S. Wang, Weidong Wendy Ma, Mirjana Zeremski, Arthur Kudla, Geoffrey Chan, Amer M. Zeidan
Journal: Blood (2019)
Comparative analysis of protein profiles of prognosis-associated proteins and KIT-related proteins in gastrointestinal stromal tumour
Authors: Y. Suehara, K. Sasa, T. Okubo, T. Hayashi, K. Sano, T. Kurihara, K. Akaike, M. Ishii, Y. Kim, K. Kaneko, T. Saito
Journal: Annals of Oncology (2019)
Functionalization of a clustered TiO2 nanotubular surface with platelet derived growth factor-BB covalent modification enhances osteogenic differentiation of bone marrow mesenchymal stem cells
Authors: Qianli Ma, Nan Jiang, Shuang Liang, Fulin Chen, Liang Fang, Xian Wang, Jinjin Wang, Lihua Chen
Journal: Biomaterials (2019)
Serious illness communication among patients with head and neck cancer.
Authors: Floyd Buen, Emily J Martin, Neil Wenger, Kirsten Buen, Anne M. Walling
Journal: Journal of Clinical Oncology (2019)

2 Background: Head and neck cancer is associated with significant morbidity and mortality, yet little is known about the frequency and content of discussions addressing patients’ values, goals of care, and treatment preferences. Methods: Using an institutional cancer registry, we conducted a retrospective analysis of 70 decedents who underwent surgical treatment for squamous cell carcinoma of the head and neck. We abstracted patients’ medical records using a standardized template. An independent reviewer re-abstracted 20% of the records. For abstracted data pertaining to documented values, goals of care, and/or treatment preferences our inter-rater reliability was greater than 93%. Results: The mean age at diagnosis was 66 years and 69% were male. An enduring advance directive, a completed Physician Order for Life Sustaining Treatment form, and a serious illness conversation documented in the medical record were noted in 27%, 4%, and 49% of the medical records, respectively. Half of the documented goals of care discussions were held in the inpatient setting, over 50% were held in the last month of life, and 25% were held in the last week of life. These conversations involved specialist palliative care providers (47%), hematologist/oncologists (41%), hospitalists (32%), head and neck surgeons (21%), radiation oncologists (19%), and intensivists (18%). None of these discussions involved patients’ primary care providers. Of those with a known location of death, 58% died in the hospital and 4 out of 5 of these patients died during attempted cardiopulmonary resuscitation. Conclusions: In this retrospective analysis, serious illness communication was documented in the minority of patients who died of head and neck cancer. These discussions occurred late in the trajectory of illness. The continuity relationships of teams treating head and neck cancer patients (e.g., head and neck surgeon, radiation/oncologist and hematologist/oncologist) situate these clinicians in the best position to enact serious illness conversations. These data suggest that opportunities to have these discussions upstream are often missed.
Tumor Antigen ROR1 Targeted Delivery of MiR-29b in Chronic Lymphocytic Leukemia Induces Epigenetic Reprograming Resulting in Cell Cycle Arrest
Authors: Chi-Ling Chiang, Swagata Goswami, Rajeswaran Mani, Frank Frissora, Zhiliang Xie, Xiaomeng Huang, Sivasubramanian Baskar, Christoph Rader, Mitch A. Phelps, Guido Marcucci, John C. Byrd, James L. Lee, Natarajan Muthusamy
Journal: Blood (2017)
Does Leukopenia Influence Performance of the New European League Against Rheumatism/American College of Rheumatology Classification Criteria in an African‐Descendent Population With Childhood‐Onset Systemic Lupus Erythematosus? Comment on the Article by Aringer et al
Authors: Adriana R. Fonseca, Marta C. F. Rodrigues, Flavio Sztajnbok, Marcelo G. P. Land, Sheila K. F. de Oliveira
Journal: Arthritis & Rheumatology (2019)
Comparison of metabolic changes between neoadjuvant chemotherapy and neoadjuvant endocrine therapy in premenopausal women with ER positive, HER2 negative breast cancer
Authors: H.-H. Ryu, S.H. Ahn, B.H. Son, J.W. Lee, B.S. Ko, J. Kim, I.Y. Chung, H. Kim
Journal: Annals of Oncology (2019)
Canada’s Single-payer Health Care System
Authors: Michael McKee
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ultrasound-accelerated catheter-directed thrombolysis versus anticoagulation for the prevention of post-thrombotic syndrome (CAVA): a single-blind, multicentre, randomised trial
Authors: Pascale Notten, Arina J ten Cate-Hoek, Carsten W K P Arnoldussen, Rob H W Strijkers, André A E A de Smet, Lidwine W Tick, Marlène H W van de Poel, Otmar R M Wikkeling, Louis-Jean Vleming, Ad Koster, Kon-Siong G Jie, Esther M G Jacobs, Harm P Ebben, Michiel Coppens, Irwin Toonder, Hugo ten Cate, Cees H A Wittens
Journal: The Lancet Haematology (2019)
Histological type analysis of 10-year follow-up of WJTOG0105: A phase III study comparing second- and third-generation regimens with concurrent thoracic radiotherapy in unresectable stage III non-small cell lung cancer
Authors: M. Tsuboi, Y. Zenke, Y. Chiba, M. Satouchi, S. Mitsuoka, J. Shimizu, H. Daga, D. Fujimoto, M. Mori, T. Aoki, T. Sawa, S. Omori, H. Saka, Y. Iwamoto, M. Okuno, T. Hirashima, K. Kashiwabara, M. Tachihara, N. Yamamoto, K. Nakagawa
Journal: Annals of Oncology (2019)
The Liver Transplant Unit
Authors: Elizabeth Adler
Journal: Annals of Internal Medicine (2019)

On Being a Doctor3 December 2019The Liver Transplant UnitElizabeth Adler, MDElizabeth Adler, MDUniversity of California, San Francisco, San Francisco, California (E.A.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M19-0487 Audio Reading - “The Liver Transplant Unit” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “The Liver Transplant Unit” by Elizabeth Adler, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I have limped through the first few months of residency. It's my vacation week, and I'm sick. I'm cycling through the stages of grief, passing quickly by denial because I'm painfully congested and moving on to anger and even jealousy at the relatively glamorous life Andrew, my partner—who is not in medicine—leads. When I say “glamorous,” I mean that he often has 2-day weekends, whereas I spend most of my Saturdays writing discharge summaries and repleting potassium.“You never get sick,” I pout.“Well, I'm always sick.”Which is actually true, but I often forget it.Andrew carries all the ... Author, Article, and Disclosure InformationAffiliations: University of California, San Francisco, San Francisco, California (E.A.)Corresponding Author: Elizabeth Adler, MD, 505 Parnassus Avenue, Room 1480, San Francisco, CA 94143; e-mail, elizabeth.[email protected]edu. PreviousarticleNextarticle Advertisement Audio Reading - “The Liver Transplant Unit” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “The Liver Transplant Unit” by Elizabeth Adler, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 3 December 2019Volume 171, Issue 11Page: 857-858KeywordsBile ductsEmotionsHeartLiverLiver diseasesLiver transplantationResidencySwimmingThoraxWalking ePublished: 3 December 2019 Issue Published: 3 December 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Early antiretroviral therapy in neonates with HIV-1 infection restricts viral reservoir size and induces a distinct innate immune profile
Authors: Pilar Garcia-Broncano, Shivaali Maddali, Kevin B. Einkauf, Chenyang Jiang, Ce Gao, Joshua Chevalier, Fatema Z. Chowdhury, Kenneth Maswabi, Gbolahan Ajibola, Sikhulile Moyo, Terence Mohammed, Thabani Ncube, Joseph Makhema, Patrick Jean-Philippe, Xu G. Yu, Kathleen M. Powis, Shahin Lockman, Daniel R. Kuritzkes, Roger Shapiro, Mathias Lichterfeld
Journal: Science Translational Medicine (2019)

Antiretroviral treatment initiation immediately after birth reduces HIV-1 viral reservoir size and alters innate immune responses in neonates.
A phase IIIb open-label study of afatinib in EGFR TKI-naïve patients (pts) with EGFR mutation-positive (EGFRm+) NSCLC: Exploratory biomarker analysis
Authors: J. Wang, J. Zhao, H. Bai, X. Wang, Y. Wang, J. Duan, H. Chen, S. Meng, Y. Tian, D.C.-L. Huang, Y.-L. Wu
Journal: Annals of Oncology (2019)
Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function
Authors: Alexander Lercher, Anannya Bhattacharya, Alexandra M. Popa, Michael Caldera, Moritz F. Schlapansky, Hatoon Baazim, Benedikt Agerer, Bettina Gürtl, Lindsay Kosack, Peter Májek, Julia S. Brunner, Dijana Vitko, Theresa Pinter, Jakob-Wendelin Genger, Anna Orlova, Natalia Pikor, Daniela Reil, Maria Ozsvár-Kozma, Ulrich Kalinke, Burkhard Ludewig, Richard Moriggl, Keiryn L. Bennett, Jörg Menche, Paul N. Cheng, Gernot Schabbauer, Michael Trauner, Kristaps Klavins, Andreas Bergthaler
Journal: Immunity (2019)
Abstract 230: Opioid-Related Cardiac Arrest Incidence and Epidemiology in Maine
Authors: Teresa MAY, David Gagnon, David B Seder, Bailey West, Patricia Lerwick, Matthew Sholl, Lee Lucas, Richard R Riker
Journal: Circulation (2019)

Introduction: The frequency of opioid-related cardiac arrest (ORCA) is increasing across several geographic regions in the United States. Understanding how Maine’s urban and rural areas are affected by ORCA is necessary to improving prevention and treatment of this public health threat. Hypothesis: Patient demographics, clinical features, rurality and survival to emergency department (ED) admission vary significantly between ORCA and non-ORCA. Methods: We evaluated the National Emergency Medical Services Information System data from 2016-2017 for all emergency 911 responses in which emergency medical services (EMS) reported non-traumatic out of hospital cardiac arrest (OOHCA). We defined ORCA as EMS suspected opioid overdose as the primary etiology, or an overdose without established etiology and naloxone administered during cardiopulmonary resuscitation (CPR). Rurality was assigned using Rural-Urban Commuting Area Codes (RUCA). Demographics and arrest-specific factors were compared between ORCA and non-ORCA, followed by logistic regression to evaluate how ORCA was associated with survival to ED admission. Results: There were 3131 EMS responses for OOHCA during the study period. One hundred sixty-eight (5%) patients met the definition of ORCA. These patients were younger (35 ± 9 years vs 62 ± 17 years, p&lt;0.001), less likely to have the reported diagnosis or treatment for chronic medical conditions (p&lt;0.001-0.02), an initial shockable rhythm (12% vs 28%, p&lt;0.001), occur in a public place (13% vs 23%, p=0.02), or be witnessed (38% vs 60%, p&lt;0.001), but more likely to receive bystander CPR (27% vs 16%, p&lt;0.001) and report illicit drug use (19% vs 2%, p&lt;0.001). ORCA was more likely to occur in metropolitan or large rural areas compared to small rural or isolated rural areas (75% vs 25%, p&lt;0.001). After adjusting for age, gender, initial shockable rhythm, witnessed arrest, bystander CPR, and rurality, patients with ORCA had an increased odds of surviving to ED admission (OR 1.83 [CI 1.11-2.95]). Conclusions: Patients in Maine with ORCA are distinctly different from patients with non-ORCA, are more likely to survive to ED admission and are seen more commonly in metropolitan and large rural areas.
MGMT protein turnover in human tumors is mediated by the ubiquitin-proteasome pathway: Phosphorylation-dependent Ub-conjugation by the Skp2-SCF complex
Authors: Chinavenmeni S. Velu, Suryakant K. Niture, Nathan I. Bailey, Kalkunte S. Srivenugopal
Journal: Cancer Research (2005)

5436  Intracellular abundance of the MGMT repair protein is a major factor contributing to the alkylator drug resistance in human cancers. Previously, we demonstrated that MGMT inactivated by O6-benzylguanine or BCNU is degraded through the ub-proteasomal pathway; however, the proteolytic system involved in the physiological turnover of MGMT has not been investigated. Therefore, we studied the role of ub-proteolysis in the maintenance of steady-state MGMT protein levels as follows. (i) First, we engineered a stable expression of human MGMT in murine ts-20 cells, which harbor a temperature-sensitive mutation for the ub-activating enzyme E1. These cells, when maintained for 10 h at 39°C (E1 is inactive) accumulated 3-fold higher MGMT content than those at 34°C (E1 active), thereby, showing the ub-conjugation is a strong requirement for MGMT degradation. (ii) Immunoprecipitation of MGMT (with MGMT antibodies) or bulk ubiquitinated proteins (with ub antibodies) from HT-29 cells and western analyses using reciprocal antibodies showed that cellular MGMT coexisted with ub-MGMT of higher molecular weights. (iii) Incubation of MGMT immunoprecipitates with purified 26 S proteasome led to the sole loss of ub- MGMT, but not the unmodified or rMGMT, showing the involvement of proteasome. (iv) Exposure of tumor cell lines to the proteasome inhibitors (PS-341, MG-132, and lactacystin) resulted in a time-dependent stabilization of MGMT activity and protein levels, accompanied by increased accumulation of ub- MGMT. (v) Extracts from eight human cell lines degraded the rMGMT protein to different extents in an ATP-Mg++ - dependent reaction; the time and extent of MGMT degradation correlated well with the steady-state levels of MGMT protein in corresponding cell lines, with higher MGMT content seen in cell lines with inefficient degradation and vice-versa. These data indicate that human tumors differ in the enzymatic activities of the ub-proteasome pathway, and this contributes to the steady-state levels of MGMT, and in turn, the level of drug resistance in a given tumor. Other experiments showed a consistent downregulation of MGMT protein just prior to or during the S phase of the cell cycle. Because the CDK inhibitor, p27kip1 is proteolysed in a similar cell cycle setting by the SCF-associated ubiquitin-ligases, we explored the phosphorylation-dependent degradation of MGMT by the skp2-containng Skp-Cullin-F-box (SCFskp2) complex. We have found the presence of a) ubiquitinated MGMT in Skp2 immunocomplexes and b) skp2 protein along with cullin in MGMT immunoprecipitates. Treatment of cell extracts with lambda phosphatase led to the loss of Skp2-MGMT association. Collectively, our findings point to a cell cycle and phosphorylation-dependent ubiquitinylation and subsequent proteasomal digestion as the mechanism that regulates MGMT content in human tumors.
Selective Targeting of Histone Deacetylase 11 Disables Metabolism of Myeloproliferative Neoplasms
Authors: Vasundhara Sharma, Lanzhu Yue, Nathan P. Horvat, Agni Christodoulidou, Afua Adutwumwa Akuffo, Mathew Beatty, Cem Murdun, Julia Billington, William E Goodheart, Eva Sahakian, Ling Zhang, John J. Powers, Narmin E. Amin, Que T. Lambert-Showers, Lancia Darville, Javier Pinilla Ibarz, Gary W. Reuther, Jennifer Lee, Xiaozhang Zheng, Pui Yee Ng, Mathew W. Martin, Gary C. Marshall, John M. Koomen, Ross L. Levine, Amit Verma, H. Leighton Grimes, Eduardo Sotomayor, Zonghong Shao, Kenneth Wright, Pearlie K. Epling-Burnette
Journal: Blood (2019)
Immunotherapy response evaluation with magnetic resonance elastography (MRE) in advanced HCC
Authors: Aliya Qayyum, Ken-Pin Hwang, Jason Stafford, Anuj Verma, Dipen M. Maru, Subramanya Sandesh, Jia Sun, Roberto Carmagnani Pestana, Rony Avritscher, Manal M. Hassan, Hesham Amin, Asif Rashid, Ignacio I. Wistuba, Richard L. Ehman, Jingfei Ma, Ahmed O. Kaseb
Journal: Journal for ImmunoTherapy of Cancer (2019)

<h3>Background</h3> Currently, there are no imaging predictors of immunotherapy outcome in hepatocellular carcinoma (HCC). The study aim was to determine if stiffness changes measured by magnetic resonance elastography (MRE) can be a predictor of immunotherapy response in patients with advanced HCC. <h3>Materials and methods</h3> This was a prospective study of 15 patients with biopsy proven-advanced HCC treated with Pembrolizumab. All patients had liver MRE and liver biopsy at baseline and at 6 weeks of therapy. Change in HCC stiffness on MRE was compared with overall survival (OS), time to disease progression (TTP), and number of intratumoral CD3+ T lymphocytes. Analysis was performed using descriptive statistics and Spearman correlation (<i>R</i>); <i>p-value</i> &lt; 0.05 was considered statistically significant. <h3>Results</h3> Nine patients were evaluable. Median age was 71 years (range, 54–78). Etiology of liver disease was HCV (<i>n</i> = 4), HBV (<i>n</i> = 1) and NASH (<i>n</i> = 4). Median OS and TTP were 44 weeks and 13 weeks, respectively. Average baseline HCC stiffness and change in HCC stiffness were 5.0 kPa and 0.12 kPa, respectively. In contrast, average non-tumor liver stiffness was 3.2 kPa, and did not significantly change at 6 weeks (<i>p</i> = 0.42). Average size of measured tumor and change in size were 4 cm and − 0.32 cm, respectively. Change in HCC stiffness at 6 weeks correlated significantly with OS (<i>R</i> = 0.81), and TTP (<i>R</i> = 0.88,<i>p</i> &lt; 0.01). Abundance of intratumoral T lymphocytes on tumor biopsy correlated significantly with HCC stiffness (<i>R</i> = 0.79,<i>p</i> = 0.007). <h3>Conclusion</h3> Our pilot MRE data suggests early change in tumor stiffness may be an indicator of immunotherapy response in patients with advanced HCC.
Tribute to Meinhard Classen
Authors: Peter D. Siersema
Journal: Endoscopy (2019)

We were sad to hear that our former Editor-in-Chief, Professor Dr. Drs. hc. Meinhard Classen, recently passed away at the age of 83. Meinhard Classen succeeded the founding Editor of Endoscopy, Ludwig Demling, in 1991 and remained in this role until 2004.
The Role of PHF19 As a Promoter of Tumorigenicity and Therapeutic Target in Multiple Myeloma
Authors: Carolina D. Schinke, Pingping Qu, Shmuel Yaccoby, Valeriy V Lyzogubov, Veronica MacLeod, Eileen M Boyle, Randal Shelton, Wen Ling, Sharmilan Thanendrarajan, Maurizio Zangari, Bart Barlogie, Frits van Rhee, Brian A Walker
Journal: Blood (2019)
A Phase 2 Study to Assess the Feasibility and Tolerance of the Combination of Elotuzumab, Lenalidomide, and Dexamethasone (ERd) in the Induction, Consolidation, and Maintenance Treatment of Transplant-Eligible Patients Newly Diagnosed with Multiple Myeloma (MM)
Authors: Jesus G. Berdeja, Tara K. Gregory, Suman Kambhampati, Bertrand M. Anz, Stefano R. Tarantolo, Anthony A. Meluch, Jeffrey V. Matous
Journal: Blood (2019)