Cytosponge-trefoil factor 3 versus usual care to identify Barrett's oesophagus in a primary care setting: a multicentre, pragmatic, randomised controlled trial
Authors: Rebecca C Fitzgerald, Massimiliano di Pietro, Maria O'Donovan, Roberta Maroni, Beth Muldrew, Irene Debiram-Beecham, Marcel Gehrung, Judith Offman, Monika Tripathi, Samuel G Smith, Benoit Aigret, Fiona M Walter, Greg Rubin, Peter Sasieni, Abhay Bagewadi, Abigail Patrick, Achuth Shenoy, Aisling Redmond, Ajay Muddu, Alex Northrop, Alice Groves, Alice Shiner, Amardeep Heer, Amrit Takhar, Amy Bowles, Andrea Jarman, Angela Wong, Angie Lucas, Anita Gibbons, Anjan Dhar, Anji Curry, Anna Lalonde, Anna Swinburn, Anne Turner, Anne-Marie Lydon, Anthony Gunstone, Arlene Lee, Arul Nambi, Arun Ariyarathenam, Ashley Elden, Ashley Wilson, Balaji Donepudi, Barbara Campbell, Basia Uszycka, Ben Bowers, Ben Coghill, Bruno de Quadros, Calvin Cheah, Carla Bratten, Carly Brown, Chantelle Moorbey, Charles Clisby, Charles Gordon, Chris Schramm, Chris Castle, Chris Newark, Chrissie Norris, Christine A'Court, Claire Graham, Clare Fletcher, Clare Grocott, Colin Rees, Corinne Bakker, Costas Paschalides, Craig Vickery, Damian Schembri, Danielle Morris, Daryl Hagan, David Cronk, David Goddard, David Graham, Dean Phillips, Deeksha Prabhu, Deepak Kejariwal, Dhirendra Garg, Diane Lonsdale, Dianne Butterworth, Donna Clements, Drew Bradman, Duncan Blake, Elizabeth Mather, Ewan O'Farrell, Florian Markowetz, Fran Adams, Francesca Pesola, Gareth Forbes, Gary Taylor, Glenn Collins, Gordon Irvine, Gysbert Fourie, Harriet Doyle, Heather Barnes, Helen Bowyer, Helen Whiting, Ian Beales, Ian Binnian, Ian Bremner, Ian Jennings, Ilona Troiceanu, Ines Modelell, Ingrid Emmerson, Jacobo Ortiz, Jacqueline Lilley, Jacquelyn Harvey, Jacqui Vicars, Jagjit Takhar, James Larcombe, Jan Bornschein, Jehad Aldegather, Jenny Johnson, Jill Ducker, Jo Skinner, Joanne Dash, Joanne Walsh, Jose Miralles, Josephine Ridgway, Julia Ince, Julie Kennedy, Kat Hampson, Kate Milne, Katherine Ellerby, Katherine Priddis, Kathy Rainsbury, Kelly Powell, Kerry Gunner, Krish Ragunath, Kyle Knox, Laura Baseley, Lauren White, Laurence Lovat, Lee Berney, Lindsay Crockett, Lisa Murray, Lisa Westwood, Lisa Chalkley, Loraine Leggett, Louise Dale, Louise Scovell, Lucy Brooks, Lucy Saunders, Lydia Owen, Maria Dilwershah, Marie Baldry, Marie Corcoran, Marie Roy, Mario Macedo, Mark Attah, Mary-Jo Anson, Matt Rutter, Matthew Wallard, Matthew Gaw, Matthew Hunt, Megan Lea-Hagerty, Melchizedek Penacerrada, Michele Bianchi, Michelle Baker-Moffatt, Michelle Czajkowski, Michelle Sleeth, Nick Brewer, Nick Wooding, Nicky Todd, Nicola Millen, Olga Zolle, Orla Whitehead, Patrick Ojechi, Patrick Moore, Paul Banim, Paula Spellar, Pradeep Bhandari, Prashant Kant, Rachel Nixon, Rebecca Russell, Rebekah Roberts, Rene Skule, Richard West, Robin Fox, Ruth Beesley, Ruth Gibbins, Ruth Osborne, S Thiagarajan, Sally Bastiman, Samantha Warburton, Samir Pai, Sarah Leith-Russell, Sarah Utting, Sarah Watson, Sarah Wytrykowski, Satish Singh, Shalini Malhotra, Sharon Woods, Shaun Conway, Sherrie Mateer, Shona Macrae, Shruti Singh, Simona Fourie, Siobhan Campbell, Siobhan Parslow-Williams, Sonica Goel, Stephen Dellar, Stephen Jones, Steve Knight, Stuart Mackay-Thomas, Stuti Mukherjee, Sue Allen, Suzanne Henry, Tara Evans, Theresa Leighton, Tim Bray, Tom Shackleton, Vanaja Santosh, Vicki Glover, Vijay Chandraraj, Will Elson, William Briggs, Zoe Barron, Zohrah Khan
Journal: The Lancet (2020)

Treatment of dysplastic Barrett's oesophagus prevents progression to adenocarcinoma; however, the optimal diagnostic strategy for Barrett's oesophagus is unclear. The Cytosponge-trefoil factor 3 (TFF3) is a non-endoscopic test for Barrett's oesophagus. The aim of this study was to investigate whether offering this test to patients on medication for gastro-oesophageal reflux would increase the detection of Barrett's oesophagus compared with standard management.