tbuckley/cabot-search huggingface dataset:
Use of the moving epidemic method (MEM) to assess national surveillance data for respiratory syncytial virus (RSV) in the Netherlands, 2005 to 2017
Authors: Laura M Vos, Anne C Teirlinck, José E Lozano, Tomás Vega, Gé A Donker, Andy IM Hoepelman, Louis J Bont, Jan Jelrik Oosterheert, Adam Meijer
Journal: Eurosurveillance (2019)

Background To control respiratory syncytial virus (RSV), which causes acute respiratory infections, data and methods to assess its epidemiology are important. Aim We sought to describe RSV seasonality, affected age groups and RSV-type distribution over 12 consecutive seasons in the Netherlands, as well as to validate the moving epidemic method (MEM) for monitoring RSV epidemics. Methods We used 2005−17 laboratory surveillance data and sentinel data. For RSV seasonality evaluation, epidemic thresholds (i) at 1.2% of the cumulative number of RSV-positive patients per season and (ii) at 20 detections per week (for laboratory data) were employed. We also assessed MEM thresholds. Results In laboratory data RSV was reported 25,491 times (no denominator). In sentinel data 5.6% (767/13,577) of specimens tested RSV positive. Over 12 seasons, sentinel data showed percentage increases of RSV positive samples. The average epidemic length was 18.0 weeks (95% confidence intervals (CI): 16.3–19.7) and 16.5 weeks (95% CI: 14.0–18.0) for laboratory and sentinel data, respectively. Epidemics started on average in week 46 (95% CI: 45–48) and 47 (95% CI: 46–49), respectively. The peak was on average in the first week of January in both datasets. MEM showed similar results to the other methods. RSV incidence was highest in youngest (0–1 and &gt;1–2 years) and oldest (&gt;65–75 and &gt; 75 years) age groups, with age distribution remaining stable over time. RSV-type dominance alternated every one or two seasons. Conclusions Our findings provide baseline information for immunisation advisory groups. The possibility of employing MEM to monitor RSV epidemics allows prospective, nearly real-time use of surveillance data.
INCOMPLETE SMALL BOWEL CAPSULE ENTEROSCOPY: STILL ROOM FOR IMPROVEMENT?
Authors: R Magalhaes, P Boal Carvalho, B Rosa, M Joao Moreira, J Cotter
Journal: Endoscopy (2019)

Small bowel capsule enteroscopy (SBCE) is considered incomplete when the dispositive does not reach the cecum during battery time. Incompletion rates go up to 15%, as described in several cohorts. Acknowledging risk factors is imperative to determine individual hazards and implement protocols that could reduce this limitation.
THE LOCATION AS A PREDICTOR OF ADENOCARCINOMA IN GRANULAR MIXED LATERALLY SPREADING TUMORS (GM-LSTS): A MULTICENTRE RESTROSPECTIVE ANALYSIS
Authors: F D'Amico, R Maselli, A Amato, F Radaelli, C Trovato, G Fiori, S Angeletti, E Di Giulio, P Soriani, M Manno, P Alessia Galtieri, A Anderloni, A Fugazza, E Chiara Ferrara, S Carrara, M Di Leo, M Spadaccini, L Lamonaca, V Craviotto, PJ Belletrutti, A Repici
Journal: Endoscopy (2019)

GM-LSTs represent approximately 1/4 of all LST and have a submucosal invasion risk of approximately 10%. Size and location represent important predictor factors of advanced neoplasia. The aim of the study was to evaluate the prevalence of cancer in patients with GM-LSTs, analyzing factors of submucosal invasion risk such as size and location.
La place du traitement par dilatation instrumentale dans les sténoses caustiques de l'oesophage
Authors: Y Ismail, J El Atmani, A El Farouki, MA Lkousse, S Oubaha, Z Samlani, K Krati
Journal: Endoscopy (2019)

La survenue d'une sténose oesophagienne est une séquelle redoutable lors de l'ingestion d'un produit caustique. Les progrès de la FOGD et des techniques de dilatations de l'oesophage permettent une dilatation instrumentale avec un maximum d'efficacité et un minimum de complications. Le but de ce travail est d'étudier l'apport de la dilatation endoscopique dans les sténoses caustiques oesophagiennes de l'adulte.
Multi-omics discovery of exome-derived neoantigens in hepatocellular carcinoma
Authors: Markus W. Löffler, Christopher Mohr, Leon Bichmann, Lena Katharina Freudenmann, Mathias Walzer, Christopher M. Schroeder, Nico Trautwein, Franz J. Hilke, Raphael S. Zinser, Lena Mühlenbruch, Daniel J. Kowalewski, Heiko Schuster, Marc Sturm, Jakob Matthes, Olaf Riess, Stefan Czemmel, Sven Nahnsen, Ingmar Königsrainer, Karolin Thiel, Silvio Nadalin, Stefan Beckert, Hans Bösmüller, Falko Fend, Ana Velic, Boris Maček, Sebastian P. Haen, Luigi Buonaguro, Oliver Kohlbacher, Stefan Stevanović, Alfred Königsrainer, Hans-Georg Rammensee
Journal: Genome Medicine (2019)

Although mutated HLA ligands are considered ideal cancer-specific immunotherapy targets, evidence for their presentation is lacking in hepatocellular carcinomas (HCCs). Employing a unique multi-omics approach comprising a neoepitope identification pipeline, we assessed exome-derived mutations naturally presented as HLA class I ligands in HCCs.
EUS-FNA FOR DUODENAL HYPOECHOIC SOLID SUBEPITHELIAL LESION DIAGNOSED BY EUS
Authors: K Akahoshi, K Akahoshi, Y Shiratsuchi, M Oya, M Kubokawa, J Gibo, K Yodoe
Journal: Endoscopy (2019)

The frequency of histological types and the usefulness of EUS-FNA for duodenal subepithelial lesions (DSEL) whose EUS image shows a hypoechoic solid mass are still unknown. The aim of this study is to clarify them.
COLONIC ESD: IS IT EASY WITH COUNTERTRACTION BY CLIP AND RUBBER BAND? A PROSPECTIVE STUDY
Authors: J Jacques, J Albouys, J Rivory, R Legros, T Ponchon, D Sautereau, M Pioche
Journal: Endoscopy (2019)

New systematic strategy by countertraction by clips and rubber band considerably facilitate the procedure. Here, we report a large prospective case series of colon ESD using This strategy.
The Economics of Taxes on Sugar-Sweetened Beverages: A Review of the Effects on Prices, Sales, Cross-Border Shopping, and Consumption
Authors: John Cawley, Anne Marie Thow, Katherine Wen, David Frisvold
Journal: Annual Review of Nutrition (2019)

During the past decade, dozens of countries, regions, and cities have enacted taxes on sugar-sweetened beverages (SSBs). They have been primarily motivated by a desire to raise prices, reduce sales and consumption, improve population health, and raise revenue. This review outlines the economic rationale for SSB taxes and illustrates their predicted effects. It reviews the research on the effects of these taxes on retail prices, sales, cross-border shopping, consumption, and product availability. The evidence indicates that the amount by which taxes increase retail prices (also called the pass-through of the tax) varies by jurisdiction, ranging from less than 50% to 100% of the tax. Sales tend to decrease significantly in the taxing jurisdiction, although this seems to be partly offset by residents increasingly shopping outside of the taxing jurisdiction (i.e., engaging in cross-border shopping).Overall, taxes lower consumption of the taxed beverages by adults, although not for all types of beverages or all groups of consumers. We conclude with suggestions for improving the design of such taxes and directions for future research.
POST-POLYPECTOMY SURVEILLANCE IN THE ENGLISH BOWEL CANCER SCREENING PROGRAMME: RESULTS OF FIRST SURVEILLANCE
Authors: SN Bonnington, L Sharp, MD Rutter
Journal: Endoscopy (2019)

The English Bowel Cancer Screening Programme (BCSP) offers biennial g-FOBt from 60 – 74 years. Post-polypectomy surveillance is offered within BCSP during the screening age range for those at “high risk” (≥5 adenomas or ≥3 at least one ≥10 mm) and “intermediate risk” (3 – 4 small adenomas or at least one ≥10 mm).
Abstract 3607: Metastasis-associated protein 1 negatively regulates expression of androgen receptor in ER-positive breast cancer cells
Authors: SeungSu Kim
Journal: Cancer Research (2017)

Abstract Androgen receptor (AR) is expressed in more than 80% of ER-positive breast cancer and its expression is correlated with better prognosis in ER-positive breast cancer. However, little is known about the regulation of AR expression in breast cancer. We have previously reported that metastasis-associated protein 1 (MTA1), a cancer-promoting gene that is overexpressed in breast cancer, increases the expression of ERα in breast cancer. Here, we investigated the role of MTA1 on AR expression in three different ER-positive breast cancer cell lines. First, small interfering RNA-mediated knockdown of MTA1 increased protein and mRNA expression of AR in MCF7, T47D, and ZR75-1. Overexpression of MTA1 down-regulated expression of AR in these cell lines. Activity of the reporter-encoding AR promoter (-2408 bp ~ +1126 bp) was decreased in the presence of MTA1 in a dose-dependent manner. Analysis of the chromatin immunoprecipitation sequencing data (http://encodeproject.org/ENCODE) revealed that MTA1 may bind to 1 kilo base downstream of AR transcription start site. Together, our results demonstrated that MTA1 negatively regulates expression of AR in breast cancer cells. These results suggest that the negative regulation of AR may be associated with the cancer promoting effects of MTA1, which may provide a therapeutic opportunity against ER-positive breast cancer. Citation Format: SeungSu Kim. Metastasis-associated protein 1 negatively regulates expression of androgen receptor in ER-positive breast cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3607. doi:10.1158/1538-7445.AM2017-3607
Patient-Centered Performance Metrics
Authors: Pete Yunyongying, Max Rich, Janet Jokela
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A systematic review of feasibility studies promoting the use of mobile technologies in clinical research
Authors: Jessie P. Bakker, Jennifer C. Goldsack, Michael Clarke, Andrea Coravos, Cynthia Geoghegan, Alan Godfrey, Matthew G. Heasley, Daniel R. Karlin, Christine Manta, Barry Peterson, Ernesto Ramirez, Nirav Sheth, Antonia Bruno, Emilia Bullis, Kirsten Wareham, Noah Zimmerman, Annemarie Forrest, William A. Wood
Journal: npj Digital Medicine (2019)

Mobile technologies, such as smart phone applications, wearables, ingestibles, and implantables, are increasingly used in clinical research to capture study endpoints. On behalf of the Clinical Trials Transformation Initiative, we aimed to conduct a systematic scoping review and compile a database summarizing pilot studies addressing mobile technology sensor performance, algorithm development, software performance, and/or operational feasibility, in order to provide a resource for guiding decisions about which technology is most suitable for a particular trial. Our systematic search identified 275 publications meeting inclusion criteria. From these papers, we extracted data including the medical condition, concept of interest captured by the mobile technology, outcomes captured by the digital measurement, and details regarding the sensors, algorithms, and study sample. Sixty-seven percent of the technologies identified were wearable sensors, with the remainder including tablets, smartphones, implanted sensors, and cameras. We noted substantial variability in terms of reporting completeness and terminology used. The data have been compiled into an online database maintained by the Clinical Trials Transformation Initiative that can be filtered and searched electronically, enabling a user to find information most relevant to their work. Our long-term goal is to maintain and update the online database, in order to promote standardization of methods and reporting, encourage collaboration, and avoid redundant studies, thereby contributing to the design and implementation of efficient, high-quality trials.
PROPHYLACTIC EFFICACY OF 7-CM PANCREATIC STENT PLACEMENT FOR POST ENDOSCOPIC AMPULLECTOMY PANCREATITIS
Authors: E Iwasaki, K Minami, S Fukuhara, S Kawasaki, H Ogata, T Kanai
Journal: Endoscopy (2019)

Endoscopic ampullectomy is a minimally invasive therapy for duodenal ampurally adenoma. With advances in endoscopic devices and methods, it became a safe and efficacious therapeutic procedure that can avoid the need for open surgery. However, there are few reports on suitable pancreatic stents after endoscopic ampullectomy. The placed pancreatic duct stent becomes unstable because of Oddi sphincter removal, so it may be better to use a relatively longer and double flapped pancreatic stent. We evaluated the length of pancreatic stent for prevention of post ampullectomy pancreatitis (PAP) retrospectively.
Crowdsourced Traffic Data as an Emerging Tool to Monitor Car Crashes
Authors: Sean D. Young, Wei Wang, Bharath Chakravarthy
Journal: JAMA Surgery (2019)

Crowdsourced Traffic Data as an Emerging Tool to Monitor Car CrashesMore than 100 deaths daily and 2.5 million emergency department visits each year result from motor vehicle crashes, making motor vehicle crashes a leading cause of death in the United States. 1,2Reducing ambulance and emergency department treatment response time for crash patients could markedly save lives. 3We evaluated whether data from the crowdsourced traffic application Waze (Google) might be used to detect motor vehicle crashes faster than current reporting methods.Methods | We obtained data on California motor vehicle incident reports (eg, crashes, road hazards, and weather conditions) from June 12, 2018, to August 1, 2018, from the California Highway Patrol (CHP) (https://media.chp.ca.gov/) and the crowdsourced traffic reporting application Waze (https://www.waze.com/).Our analysis focused on the 406 559 Waze user incident reports and the 7776 CHP crash reports (of 18 582 total CHP reports).The University of California, Los Angeles Institutional Review Board waived this study because data are anonymous and aggregated.A support vector machine learning model was created based on a subset of the data (ie, training phase) to identify Waze user-reported alerts corresponding to each CHP-reported crash (ie, crash alerts).The features of the model included report time, location, type of incident reported, and user confidence in the reports.Using 10-fold cross-validation, we assessed precision (positive predictive value) and recall (sensitivity) on the remaining subset of the data (ie, test phase) to determine how well the model estimated CHP-reported crashes.We report results on the mean lead time that Waze reports occurred before CHP reports for each crash broken down by the order of Waze alerts received (eg, first, second, third Waze reports).Analyses were conducted using Python software, version 2.7 (Python Software Foundation).
The current state of molecular testing in the treatment of patients with solid tumors, 2019
Authors: Wafik S. El‐Deiry, Richard M. Goldberg, Heinz‐Josef Lenz, Anthony F. Shields, Geoffrey T. Gibney, Antoinette R. Tan, Jubilee Brown, Burton Eisenberg, Elisabeth I. Heath, Surasak Phuphanich, Edward Kim, Andrew J. Brenner, John L. Marshall
Journal: CA A Cancer Journal for Clinicians (2019)

The world of molecular profiling has undergone revolutionary changes over the last few years as knowledge, technology, and even standard clinical practice have evolved. Broad molecular profiling is now nearly essential for all patients with metastatic solid tumors. New agents have been approved based on molecular testing instead of tumor site of origin. Molecular profiling methodologies have likewise changed such that tests that were performed on patients a few years ago are no longer complete and possibly inaccurate today. As with all rapid change, medical providers can quickly fall behind or struggle to find up-to-date sources to ensure he or she provides optimum care. In this review, the authors provide the current state of the art for molecular profiling/precision medicine, practice standards, and a view into the future ahead.
Abstract 20157: Short-term Exposure to Low Ambient Temperature and Large Temperature Difference Significantly Increased Home Blood Pressure
Authors: Ching-Chang Huang, Ying-Hsien Chen, Chi-Sheng Hung, Tse-Pin Hsu, Jen-Kuang Lee, Pao-Yu Chuang, Yi-Lwun Ho
Journal: Circulation (2017)

Introduction: Cross-sectional and longitudinal studies revealed association between low ambient temperature and increased office blood pressure, but few studies evaluated the effect of short-term e...
AT THE EDGE OF OUR INTEREST – ANAL INTRAEPITHELIAL NEOPLASIA
Authors: R Prochazka
Journal: Endoscopy (2019)

The aim of the study was to acquaint the gastroenterologist community with the anal intraepithelial neoplasia, the precursor lesion of the anal squamous carcinoma, and more importantly to introduce a novel approach to its detection and the treatment.
Abstract 18862: Joint Effects of Obstructive Sleep Apnea and Resistant Hypertension on Chronic Heart Failure
Authors: Anping Cai, Yingling Zhou, Jiyan Chen, Ling Wang
Journal: Circulation (2017)

Introduction: Obstructive sleep apnea (OSA) and resistant hypertension (RHTN) are major risk factors of chronic heart failure (CHF), but limited information is available about the joint effects of ...
INCOMPLETE MYOTOMY DUE TO EXTRAMUSCULAR DISSECTION DURING THE POEM: DESCRIPTION AND DETECTION OF A PROCEDURE FAILURE
Authors: C Guarner-Argente, M Murzi, J Colan, J Gordillo, S Fernandez-Ananin, C Balague, E Targarona, C Guarner
Journal: Endoscopy (2019)

Incomplete myotomy is rare during the POEM for achalasia. An extramuscular dissection can lead to this technique failure. We present a videocase and analyze the images for its detection.
AUTOMATED REAL TIME ENDOSCOPIC SCORING BASED ON MACHINE LEARNING IN ULCERATIVE COLITIS: RED DENSITY RELIABILITY AND RESPONSIVENESS STUDY
Authors: P Bossuyt, S Vermeire, M Ferrante, T Makino, G De hertogh, R Bisschops
Journal: Endoscopy (2019)

Histological remission predicts favourable long term outcome in ulcerative colitis (UC). Operator independent automated digital scoring of endoscopic and histological inflammation in UC could provide an objective and predictive evaluation tool of remission. The aim of this study was to test the operating properties of the Red Density (RD) score.
Abstract 19872: Discontinuation of Combination Immunotherapy in Cardiac Sarcoidosis is Associated With Radiologic and Clinical Disease Recurrence
Authors: Purvi Parwani, David G Rosenthal, Tyler Murray, Bryan Benn, Laura Koth, Miguel H Pampaloni, Julie Zikherman, Vasanth V Vedantham
Journal: Circulation (2017)

Introduction: Immunosuppression (IS) is standard of care for treatment of cardiac sarcoidosis (CS) and is associated with reduction in cardiac morbidity. However, the optimal duration of therapy ha...
Evaluating the impact of organisational digital maturity on clinical outcomes in secondary care in England
Authors: Guy Martin, Jonathan Clarke, Felicity Liew, Sonal Arora, Dominic King, Paul Aylin, Ara Darzi
Journal: npj Digital Medicine (2019)

All healthcare systems are increasingly reliant on health information technology to support the delivery of high-quality, efficient and safe care. Data on its effectiveness are however limited. We therefore sought to examine the impact of organisational digital maturity on clinical outcomes in secondary care within the English National Health Service. We conducted a retrospective analysis of routinely collected administrative data for 13,105,996 admissions across 136 hospitals in England from 2015 to 2016. Data from the 2016 NHS Clinical Digital Maturity Index were used to characterise organisational digital maturity. A multivariable regression model including 12 institutional covariates was utilised to examine the relationship between one measure of organisational digital maturity and five key clinical outcome measures. There was no significant relationship between organisational digital maturity and risk-adjusted 30-day mortality, 28-day readmission rates or complications of care. In multivariable analysis risk-adjusted long length of stay and harm-free care were significantly related to aspects of organisational digital maturity; digitally mature hospitals may not only deliver more harm-free care episodes but also may have a significantly increased risk of patients experiencing a long length of stay. Organisational digital maturity is to some extent related to selected clinical outcomes in secondary care in England. Digital maturity is, however, also strongly linked to other institutional factors that likely play a greater role in influencing clinical outcomes. There is a need to better understand how health IT impacts care delivery and supports other drivers of hospital quality.
A Novel Surface Enhanced Raman Catheter for Rapid Detection, Classification, and Grading of Oral Cancer
Authors: Girish Chundayil Madathil, Subramania Iyer, Krishnakumar Thankappan, G. Siddaramana Gowd, Shantikumar Nair, Manzoor Koyakutty
Journal: Advanced Healthcare Materials (2019)

Abstract Fabrication and testing of a novel nanostructured surface‐enhanced Raman catheter device is reported for rapid detection, classification, and grading of normal, premalignant, and malignant tissues with high sensitivity and accuracy. The sensor part of catheter is formed by a surface‐enhanced Raman scattering (SERS) substrate made up of leaf‐like TiO 2 nanostructures decorated with 30 nm sized Ag nanoparticles. The device is tested using a total of 37 patient samples wherein SERS signatures of oral tissues consisting of malignant oral squamous cell carcinoma (OSCC), verrucous carcinoma, premalignant leukoplakia, and disease‐free conditions are detected and classified with an accuracy of 97.24% within a short detection‐cum‐processing time of nearly 25–30 min per patient. Neoplastic grade changes detected using this device correlate strongly with conventional pathological data, enabling correct classification of tumors into three grades with an accuracy of 97.84% in OSCC. Thus, the potential of a SERS catheter device as a point‐of‐care pathological tool is shown for the rapid and accurate detection, classification, and grading of solid tumors.