tbuckley/cabot-search huggingface dataset:
The prognostic and therapeutic implications of circulating tumor cell phenotype detection based on epithelial–mesenchymal transition markers in the first‐line chemotherapy of HER2‐negative metastatic breast cancer
Authors: Xiuwen Guan, Fei Ma, Chunxiao Li, Shiyang Wu, Shangying Hu, Jiefen Huang, Xiaoying Sun, Jiayu Wang, Yang Luo, Ruigang Cai, Ying Fan, Qiao Li, Shanshan Chen, Pin Zhang, Qing Li, Binghe Xu
Journal: Cancer Communications (2019)

Abstract Background Epithelial–mesenchymal transition (EMT) is implicated in the metastatic process and presents a challenge to epithelial cell adhesion molecule‐based detection of circulating tumor cells (CTCs), which have been demonstrated to be a prognostic indicator in metastatic breast cancer. Although evidence has indicated that heterogeneity of CTCs based on EMT markers is associated with disease progression, no standard recommendations have been established for clinical practice. This study aimed to evaluate the prognostic significance of dynamic CTC detection based on EMT for metastatic breast cancer patients. Methods We enrolled 108 human epidermal growth factor receptor 2‐negative metastatic breast cancer patients from the prospective phase III CAMELLIA study and applied the CanPatrol CTC enrichment technique to identify CTC phenotypes (including epithelial CTCs, biphenotypic epithelial/mesenchymal CTCs, and mesenchymal CTCs) in peripheral blood samples. Receiver operating characteristic curve analyses of total CTC count and the proportion of mesenchymal CTCs for predicting the 1‐year progression‐free survival (PFS) rate were conducted to determine the optimal cut‐off values, and Kaplan–Meier analysis and Cox proportional hazards regression analysis were performed to investigate the prognostic value of the cut‐off values of both total CTC count and the proportion of mesenchymal CTCs in combination. Results For predicting the 1‐year PFS rate, the optimal cut‐off value of total CTC count was 9.5 (Area under the curve [AUC] = 0.538, 95% confidence interval [CI] = 0.418–0.657), and that of the proportion of mesenchymal CTCs was 10.7% (AUC = 0.581, 95% CI = 0.463–0.699). We used the two cut‐off values in combination to forecast PFS in which the total CTC count was equaled to or exceeded 10/5 mL with the proportion of mesenchymal CTCs surpassed 10.7%. Patients who met the combined criteria had significantly shorter median PFS than did those who did not meet the criteria (6.2 vs. 9.9 months, P =0.010). A nomogram was constructed based on the criteria and significant clinicopathological characteristics with a C‐index of 0.613 ( P = 0.010). Conclusions The criteria, which combine the total CTC count and the proportion of mesenchymal CTCs, may be used to monitor therapeutic resistance and predict prognosis in patients with metastatic breast cancer. Trial registration ClinicalTrials.gov . NCT01917279. Registered on 19 July 2013, https://clinicaltrials.gov/ct2/show/NCT01917279?term=NCT01917279&amp;rank=1 .
UTILITY OF SHOCK INDEX IN 24,636 PATIENTS PRESENTING WITH ACUTE CORONARY SYNDROME
Authors: Ayman A. El-Menyar, Khalid AlHabib, Mohammad Zubaid, Alawi Alsheikh-Ali, Kadhim Sulaiman, Wael Almahmeed, Haitham Amin, Ahmed Al-Motarreb, Anhar Ullah, Jassim Al Suwaidi
Journal: Journal of the American College of Cardiology (2019)
NEUROLOGICAL EVENT RATES AND ASSOCIATED RISK FACTORS IN ACUTE TYPE B AORTIC DISSECTIONS TREATED ENDOVASCULARLY
Authors: Benedikt Reutersberg, Thomas Gleason, Nimesh Desai, Marek P. Ehrlich, Arturo Evangelista-Masip, Alan Braverman, Truls Myrmel, Edward Chen, Anthony Estrera, Marc Schermerhorn, Eduardo Bossone, Daniel Montgomery, Kim Eagle, Thoralf Sundt, Himanshu Patel, Santi Trimarchi, Hans-Henning Eckstein
Journal: Journal of the American College of Cardiology (2019)
LONG-TERM OUTCOMES OF DRUG ELUTING STENT STRATIFIED BY POLYMER IN PATIENTS WITH CORONARY ARTERY DISEASE
Authors: Parth Parikh, Kinjal Banerjee, Amar Krishnaswamy, Christopher Bajzer, Ravi Nair, Russell Raymond, E. Murat Tuzcu, Samir Kapadia
Journal: Journal of the American College of Cardiology (2019)
PATTERNS OF ANTICOAGULATION USE IN CANCER PATIENTS WITH ATRIAL FIBRILLATION AND/OR ATRIAL FLUTTER
Authors: Michael Fradley, Kerry Ellenberg, Justin Swanson, Anant Kharod, Anh Thy H. Nguyen, Sara Khodor, Shreya Mishra, Linh M. Duong, Nirav Shah, Merna Armanious, Isaac Rhea, Matthew Schabath, Kevin Kip
Journal: Journal of the American College of Cardiology (2019)
MMSplice: modular modeling improves the predictions of genetic variant effects on splicing
Authors: Jun Cheng, Thi Yen Duong Nguyen, Kamil J. Cygan, Muhammed Hasan Çelik, William G. Fairbrother, žiga Avsec, Julien Gagneur
Journal: Genome biology (2019)

Predicting the effects of genetic variants on splicing is highly relevant for human genetics. We describe the framework MMSplice (modular modeling of splicing) with which we built the winning model of the CAGI5 exon skipping prediction challenge. The MMSplice modules are neural networks scoring exon, intron, and splice sites, trained on distinct large-scale genomics datasets. These modules are combined to predict effects of variants on exon skipping, splice site choice, splicing efficiency, and pathogenicity, with matched or higher performance than state-of-the-art. Our models, available in the repository Kipoi, apply to variants including indels directly from VCF files.
ASSOCIATION BETWEEN DEPRESSION AND THE PREVALENCE OF ATRIAL FIBRILLATION
Authors: Nino Isakade, Ayman Tahhan, Pratik Sandesara, Salim Hayek, Ayman Alkhoder, Mohamad Gafeer, Belal Kaseer, Kaavya Chivukula, Shuai Zheng, Alvaro Alonso, Viola Vaccarino, Arshed Quyyumi, Amit Shah
Journal: Journal of the American College of Cardiology (2019)
Reduced Expression of DOCK4 Leads to Increased Protein Phosphorylation and Migration of Hematopoietic Stem/Progenitor Cells
Authors: Sriram Sundaravel, Wen Liang-Kuo, Hui Liu, Jong Jeong, Gaurav Choudhary, Tushar Damodar Bhagat, Shanisha Gordon, Amit Verma, Amittha Wickrema
Journal: Blood (2018)
Two types of amyloidosis presenting in a single patient: a case series
Authors: M. Hasib Sidiqi, Ellen D. McPhail, Jason D. Theis, Surendra Dasari, Julie A. Vrana, Maria Eleni Drosou, Nelson Leung, Suzanne Hayman, S. Vincent Rajkumar, Rahma Warsame, Stephen M. Ansell, Morie A. Gertz, Martha Grogan, Angela Dispenzieri
Journal: Blood Cancer Journal (2019)

Abstract The amyloidoses are a group of disorders with overlapping clinical presentations, characterized by aggregation and tissue deposition of misfolded proteins. The nature and source of the amyloidogenic protein determines therapy, therefore correct subtyping is critical to patient management. We report the clinicopathologic features of nine patients diagnosed with two amyloid types confirmed by liquid chromatography-coupled tandem mass spectrometry. The most common types were transthyrethin ( n = 9) and immunoglobulin-derived ( n = 7). Two patients did not have immunoglobulin-derived amyloidosis despite the presence of a monoclonal gammopathy. Eight patients were diagnosed with two types concurrently, and one patient had an 11-year interval between diagnoses. Histopathological distribution of amyloid was variable with vascular, interstitial, and periosteal deposits seen. Identification of a second type was incidental in seven patients, but led to genetic counselling in one patient and therapy directed at both amyloid subtypes in another. With longer survival of myeloma and AL amyloidosis patients and increasing prevalence of patients with wild-type transthyretin amyloidosis due to an aging population, the phenomenon of two amyloid types in a single patient will be encountered more frequently. In light of revolutionary new therapies for transthyretin amyloidosis (patisiran, tafamidis, and inotersen), recognition of dual amyloid types is highly clinically relevant.
ASSOCIATION OF HUMANIN A NOVEL MITOCHONDRIAL PROTEIN WITH HUMAN HEART FAILURE: AN ASSESSMENT OF MORTALITY AND CLINICAL BIOMARKERS
Authors: Sati Patel, Jennifer D. Hwang, Hemalatha Narayanasamy, Luanda Grazette, Jeffrey Tran, Pinchas Cohen, Junxiang Wan
Journal: Journal of the American College of Cardiology (2019)
Magnesium supplementation in the treatment of pseudoxanthoma elasticum: A randomized trial
Authors: Sharon Rose, Shelbi Jim On, Wayne Fuchs, Chen Chen, Robert Phelps, Davida Kornreich, Madelaine Haddican, Giselle Singer, Vicky Wong, Danielle Baum, Anjali Vekaria, Matthew Gagliotti, Ruiqi Huang, Mayte Suárez-Fariñas, Sharon F. Terry, Mark Lebwohl
Journal: Journal of the American Academy of Dermatology (2019)
IMPACT OF PATIENT CHARACTERISTICS ON SENSITIVITY AND SPECIFICITY FOR LEFT VENTRICULAR HYPERTROPHY BY ECG IN A LARGE, DIVERSE PATIENT POPULATION
Authors: Maxwell Bressman, Alon Mazori, Eric Shulman, Jay J. Chudow, Ythan Goldberg, Kevin Ferrick, John Fisher, Mario Garcia, Luigi DiBiase, Andrew Krumerman
Journal: Journal of the American College of Cardiology (2019)
INVESTIGATING THE RELATION OF HYPERTENSIVE DISEASE WITH VASCULAR BRAIN INJURY AND COGNITIVE IMPAIRMENT USING HEART-BRAIN MAGNETIC RESONANCE IN PATIENTS WITH CARDIOVASCULAR RISK FACTORS: THE HEART-BRAIN CONNECTION STUDY
Authors: Raquel Amier, Nick Marcks, Astrid Hooghiemstra, Robin Nijveldt, Mark van Buchem, Albert De Roos, Geert Jan Biessels, L. Jaap Kappelle, Robert van Oostenbrugge, Michiel Bots, Wiro Niessen, Matthias van Osch, Wiesje van der Flier, Hans-Peter Brunner-La Rocca, Albert van Rossum
Journal: Journal of the American College of Cardiology (2019)
DIFFERENCES BETWEEN BLACK AND WHITE AMERICANS WITH STABLE CHEST PAIN: ASCVD RISK SCORE, CORONARY ARTERY DISEASE AND CARDIAC EVENTS IN PROMISE (PROSPECTIVE MULTICENTER IMAGING STUDY FOR EVALUATION OF CHEST PAIN)
Authors: Devvora Olalere, Thomas Mayrhofer, Dahlia Banerji, Lili Zhang, Daniel O. Bittner, Hamed Emami, Nandini Meyersohn, Stefan Puchner, Rowena Dolor, Daniel Mark, Maros Ferencik, Pamela Douglas, Udo Hoffmann, Michael T. Lu
Journal: Journal of the American College of Cardiology (2019)
TEMPORAL TRENDS IN TIME TO INVASIVE CORONARY ANGIOGRAPHY AND ASSOCIATION WITH CLINICAL OUTCOMES FOLLOWING NON-ST ELEVATION ACUTE MYOCARDIAL INFARCTION IN UNITED STATES
Authors: Muhammad Rashid, David Fischman, Sara Martinez, Quinn Capers, Michael Savage, Azfar Zaman, Nick Curzen, Mohamed Mohamed, Chun Shing Kwok, Tim Kinnaird, Mamas A. Mamas
Journal: Journal of the American College of Cardiology (2019)
HDAC6 selective inhibition of melanoma patient T-cells augments anti-tumor characteristics
Authors: Andressa S. Laino, B. C. Betts, A. Veerapathran, I. Dolgalev, A. Sarnaik, S. N. Quayle, S. S. Jones, J. S. Weber, David M. Woods
Journal: Journal for ImmunoTherapy of Cancer (2019)

Therapies targeting anti-tumor T-cell responses have proven successful in the treatment of a variety of malignancies. However, as most patients still fail to respond, approaches to augment immunotherapeutic efficacy are needed. Here, we investigated the ability of histone deacetylase 6 (HDAC6)-selective inhibitors to decrease immunosuppression and enhance immune function of melanoma patient T-cells in ex vivo cultures.
Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors
Authors: Mar Cabeza-Cabrerizo, Janneke van Blijswijk, Stephan Wienert, Daniel Heim, Robert P. Jenkins, Probir Chakravarty, Neil Rogers, Bruno Frederico, Sophie Acton, Evelyne Beerling, Jacco van Rheenen, Hans Clevers, Barbara U. Schraml, Marc Bajénoff, Michael Gerner, Ronald N. Germain, Erik Sahai, Frederick Klauschen, Caetano Reis e Sousa
Journal: Science Immunology (2019)

Many tissue cDCs are maintained as single subset clones, which disperse upon infection with acute recruitment of pre-cDCs.
IN VIVO PREVALENCE AND CLINICAL CHARACTERISTICS OF A HEALED PLAQUE ASSESSED BY OPTICAL COHERENCE TOMOGRAPHY AND ITS RELEVANCE TO PLAQUE BURDEN ASSESSED BY INTRAVASCULAR ULTRASOUND
Authors: Eisuke Usui, Gary Mintz, Tetsumin Lee, Mitsuaki Matsumura, Masahiro Hoshino, Yoshihisa Kanaji, Tadashi Murai, Taishi Yonetsu, Tsunekazu Kakuta, Akiko Maehara
Journal: Journal of the American College of Cardiology (2019)
TEMPORAL BURDEN AND OUTCOMES OF PERCUTANEOUS CORONARY INTERVENTION WITH ATRIAL FIBRILLATION IN THE UNITED STATES
Authors: Yusuke Morita, Toka Hamaguchi, Tetsuya Haruna, Yoshisumi Haruna, Eisaku Nakane, Yuhei Yamaji, Hideyuki Hayashi, Michiya Hanyu, Moriaki Inoko, Tazuke Kofukai Foundation
Journal: Journal of the American College of Cardiology (2019)
PREVALENCE OF UNEXPLAINED LEFT VENTRICULAR HYPERTROPHY BY CARDIAC MAGNETIC RESONANCE IMAGING IN THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS
Authors: Daniele Massera, Robyn McClelland, Bharath Ambale Venkatesh, Antoinette Gomes, W. Hundley, Nadine Kawel-Boehm, Kihei Yoneyama, David Owens, Mario Garcia, Mark Sherrid, Jorge Kizer, Joao Lima, David A. Bluemke
Journal: Journal of the American College of Cardiology (2019)
TIME TO FIRST CIGARETTE, A NICOTINE DEPENDENCE PHENOTYPE, AND ACUTE MYOCARDIAL INFARCTION RISK IN CHINESE MALE SMOKERS
Authors: Yehao Xu, Wanqing Wu, Yan Guo, Yanzhuo Li, Xiaomin Huang, Jiangming Huang, Hui Zhao, Yao Wang, Qunhui Zhang, Junda Zhong, Jianyu Huang, Lin Xu
Journal: Journal of the American College of Cardiology (2019)
IMPACT OF HOSPITAL TYPE ON TRANSCATHETER AORTIC VALVE REPLACEMENT MORTALITY
Authors: Keerat Rai Ahuja, Mohamed Gad, Najdat Bazarbashi, Antonette Karrthik, Manpreet Kaur, Beni Verma, Yasser Sammour, Samir Kapadia, Mouin Abdallah
Journal: Journal of the American College of Cardiology (2019)
Abstract 221: Autophagy is Involved in the Protective Effect of Endophilin A2 on H <sub>2</sub> O <sub>2</sub> -induced Apoptosis in H9C2 Cardiomyocytes
Authors: Yun Liu, Hai-Qi Liu, Xin-Qiu-Yue Wang, Huan-Jia Shen
Journal: Circulation Research (2018)

Apoptosis plays a critical role in normal embryonic development and tissue homeostasis regulation. EndophilinA2 (EndoA2) is widely reported to regulate endocytosis. Additionally, EndoA2 has been demonstrated to be involved in tumor metastasis, neuroregulation and vascular function. In this study, we used siRNA and Ad-EndoA2 transfection strategy to investigate whether EndoA2 provides a protective effect against apoptosis induced by H 2 O 2 in H9C2 cardiomyocytes and the underlying mechanisms. We found that EndoA2 siRNA knockdown promoted H 2 O 2 -induced apoptosis in H9C2 cardiomyocytes, evidenced by decreased cell number, increased apoptotic cells, and activation of caspase-3. In contrast, EndoA2 overexpression showed the opposite effects and inhibited H 2 O 2 -induced apoptosis in H9C2 cardiomyocytes. Further studies revealed that EndoA2 overexpression strengthened autophagy, evidenced by the increased LC3 II/I ratio and P62 degradation,whereas EndoA2 siRNA knockdown produced the opposite effects. Furthermore, we revealed that there was an interaction between Bif-1 and Beclin-1. Upon H 2 O 2 treatment, the association of Bif-1 and Beclin-1 remarkably increased. EndoA2 overexpression further promoted the binding of Bif-1 with Beclin-1, whereas EndoA2 siRNA knockdown reduced this association. These data strongly suggested that EndoA2 inhibited H 2 O 2 -induced apoptosis in H9C2 cardiomyocytes, possibly by promoting Bif-1 to form a complex with Beclin-1 and strengthening autophagy. This study provides a novel target for heart diseases.
Abstract 20550: Decisional Conflict in Peripheral Arterial Disease: Association With Treatment Choice and Health Status in the PORTRAIT Registry
Authors: Jeremy Provance, John A Spertus, David Safley, Phil Jones, Karen Sepucha, Erica Spatz, Carole Decker, Kim G Smolderen
Journal: Circulation (2017)

Introduction: Engaging patients in medical decision-making is important, especially for conditions such as peripheral arterial disease (PAD) that have multiple treatment options. Lack of informatio...
Results of the Pivotal STORM Study (Part 2) in Penta-Refractory Multiple Myeloma (MM): Deep and Durable Responses with Oral Selinexor Plus Low Dose Dexamethasone in Patients with Penta-Refractory MM
Authors: Ajai Chari, Dan T. Vogl, Meletios A Dimopoulos, Ajay K Nooka, Carol Ann Huff, Philippe Moreau, Craig E. Cole, Joshua Richter, David Dingli, Ravi Vij, Sascha A Tuchman, Marc S Raab, Katja Weisel, Michel Delforge, David Kaminetzky, Robert Frank Cornell, A Keith Stewart, James Hoffman, Kelly N. Godby, Terri L Parker, Moshe Levy, Martin Schreder, Nathalie Meuleman, Laurent Frenzel, Mohamad Mohty, Choquet Sylvain, Andrew J. Yee, Maria Gavriatopoulou, Luciano J Costa, Jatin J. Shah, Carla Picklesimer, Jean-Richard Saint-Martin, Lingling Li, Michael G. Kauffman, Sharon Shacham, Paul Richardson, Sundar Jagannath
Journal: Blood (2018)
A new T helper 17 cytokine in hidradenitis suppurativa: antimicrobial and proinflammatory role of interleukin‐26
Authors: E. Scala, R. Di Caprio, S. Cacciapuoti, G. Caiazzo, A. Fusco, E. Tortorella, G. Fabbrocini, A. Balato
Journal: British Journal of Dermatology (2019)

Interleukin (IL)‐26 is a signature T helper 17 cytokine described as a proinflammatory and antimicrobial mediator. So far, IL‐26 has been reported in several immune‐mediated inflammatory diseases, but its involvement in inflammatory skin disorders is poorly known. To investigate the role of IL‐26 in hidradenitis suppurativa (HS), through its involvement in antimicrobial activity. IL‐26 was assessed in patients with HS through gene expression and protein analysis at skin and circulating levels. Ex vivo HS organ skin cultures, together with IL‐26 antibody treatment, were performed to determine the IL‐26 activity. Peripheral blood mononuclear cells (PBMCs) from patients with HS and healthy controls were either silenced or not with IL‐26 small interfering (si)RNA in order to measure its antimicrobial, cytotoxic and phagocytic activities against Staphylococcus aureus. Firstly, we observed that IL‐26 is able to modulate the proinflammatory response at the immune cell level. IL‐26 was increased in the plasma of patients with HS compared with healthy controls. Subsequently, we explored the bactericidal, cytotoxic and phagocytic activities of PBMCs against S. aureus in patients with HS and healthy controls. These activities were lower in patients with HS than in controls. Remarkably, the killing activities were reduced when healthy control PBMCs were transfected with IL‐26 siRNA. However, the transfection did not affect the killing activity of HS PBMCs, supporting the idea that IL‐26 lacks efficacy in HS. Our findings suggest that infection susceptibility in HS might be related to IL‐26. Although the role of bacteria remains controversial in HS, this paper supports that there is a defect of antimicrobial response in these patients. What's already known about this topic? Interleukin (IL)‐26 is a T helper 17 cytokine described as an antimicrobial and proinflammatory mediator. IL‐26 has been reported in immune‐mediated inflammatory diseases, but its involvement in inflammatory skin disorders remains unclear. Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder characterized by deficiency of IL‐20 and IL‐22 (a close homologue of IL‐26), which causes antimicrobial peptide pauperization leading to severe and recurrent skin infections. What does this study add? IL‐26 plasma levels are higher in patients with HS than in healthy control individuals. The antimicrobial activity of IL‐26 might be ineffective in patients with HS. What is the translational message? Cutaneous antimicrobial incompetence in HS could be related to IL‐26.
TRENDS IN UTILIZATION OF ADVANCED HEART FAILURE THERAPIES AND OUTCOMES AMONG MYOCARDITIS PATIENTS WHO UNDERWENT ENDOMYOCARDIAL BIOPSY: INSIGHTS FROM NATIONWIDE INPATIENT SAMPLE
Authors: Moghniuddin Mohammed, Venkat Lakshmi Kishan Vuddanda, Juwairiya Arshi, Nicholas Haglund, Travis Abicht, Andrew Sauer, Zubair Shah
Journal: Journal of the American College of Cardiology (2019)
Correction: Inotuzumab ozogamicin in pediatric patients with relapsed/refractory acute lymphoblastic leukemia
Authors: Deepa Bhojwani, Richard Sposto, Nirali N. Shah, Vilmarie Rodriguez, Constance Yuan, Maryalice Stetler-Stevenson, Maureen M. O’Brien, Jennifer L. McNeer, Amrana Quereshi, Aurelie Cabannes, Paul Schlegel, Claudia Rossig, Luciano Dalla-Pozza, Keith August, Sarah Alexander, Jean-Pierre Bourquin, Michel Zwaan, Elizabeth A. Raetz, Mignon L. Loh, Susan R. Rheingold
Journal: Leukemia (2019)

We thank the research coordinators and following physicians at pediatric cancer centers for contributing data to this project: Prashant Hiwarkar and Jayashree Motwani, Birmingham Women’s and Children’s Hospital, UK; Kelly Malone, Children’s Hospital of Colorado, USA; Mylene Bassal, Children’s Hospital of Eastern Ontario, Canada; Yoav Messinger and Joanna Perkins, Children’s Hospital of Minnesota, USA; Van Huynh, Children’s Hospital of Orange County, USA; Richard Ho, Children’s Hospital at Vanderbilt, USA; Joanne Chuah and Jessa Morales, Children’s Hospital at Westmead, Australia; Donald Wells, Dell Children’s Hospital, USA; Nicolas Boissel, Hospital Saint-Louis, France; Tannie Huang, Kaiser Permanente, USA; Stacey Marjerrison, McMaster Children’s Hospital, Canada; William Carroll and Joanna Pierro, New York University Langone Medical Center, USA; Ajay Vora, Sheffield Children’s Hospital, UK; Donna Lancaster, The Royal Marsden Hospital, UK; Lucie Šrámková, University Hospital Motol, Czech Republic; Chatchawin Assanasen, University of Texas Health Science Center, San Antonio, USA; Rupert Handgretinger, University of Tübingen, Germany.
Abstract P3-12-11: Prophylactic application of SkinSafe film strips to the inframammary fold prevents moist desquamation during irradiation for breast cancer in a prospective trial
Authors: D Garren, B Le, R Vasireddy, L Flynn, K Forster, L Malina, Y Dorfman
Journal: Cancer Research (2019)

Abstract Purpose: To investigate the effect of prophylactic use of SafeSkin films strips applied to the inframammary fold during whole breast or reconstructed breast irradiation to avoid moist desquamation to the inframammary fold. Materials and Methods: Between November 15, 2016 and April 17, 2018, a total of 30 patients were recruited, with 29 patients contributing to analysis, and one patient with bilateral breast cancer. Areas of the breast treatment field not covered by the film were treated with physician's choice of cream, (80% Jean's Cream, 13% Aquafor, and 7% with no topical therapy). The treatment field was photographed weekly. SkinSafe strips were reapplied as needed, but were not applied if erythema was already observed in the inframammary fold. Severity of skin reaction was assessed using the RTOG scale. Results: There was only one treatment interruption, against medical advice, due to axillary discomfort. One patient refused further trial participation after the first day. No short or long term side effects of film use were noted. Inframammary desquamation developed in only one patient, who tried to replicate the increased comfort of her inframammary tape with adhesive bandages when her tape came off. There was no moist desquamation under the SkinSafe film in the inframammary field in any patient. Axillary moist desquamation, where no film, but rather physician's choice of topical cream was applied, remained at 35%. Areas of skin adjacent to the SkinSafe film showed desquamation in 9.7% of patients, 0.5-1 cm in maximal diameter, all of which had resolved at time of completion. Conclusions: Prophylactic use of SkinSafe film strips applied to the inframammary fold substantially reduces or eliminates the risk of inframammary desquamation during breast radiation. Citation Format: Garren D, Le B, Vasireddy R, Flynn L, Forster K, Malina L, Dorfman Y. Prophylactic application of SkinSafe film strips to the inframammary fold prevents moist desquamation during irradiation for breast cancer in a prospective trial [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr P3-12-11.