tbuckley/cabot-search huggingface dataset:
Development and Validation of a Prediction Model for Prehospital Triage of Trauma Patients
Authors: Eveline A. J. van Rein, Rogier van der Sluijs, Frank J. Voskens, Koen W. W. Lansink, R. Marijn Houwert, Rob A. Lichtveld, Mariska A. de Jongh, Marcel G. W. Dijkgraaf, Howard R. Champion, Frank J. P. Beeres, Luke P. H. Leenen, Mark van Heijl
Journal: JAMA Surgery (2019)

Prehospital trauma triage protocols are used worldwide to get the right patient to the right hospital and thereby improve the chance of survival and avert lifelong disabilities. The American College of Surgeons Committee on Trauma set target levels for undertriage rates of less than 5%. None of the existing triage protocols has been able to achieve this target in isolation.To develop and validate a new prehospital trauma triage protocol to improve current triage rates.In this multicenter cohort study, all patients with trauma who were 16 years and older and transported to a trauma center in 2 different regions of the Netherlands were included in the analysis. Data were collected from January 1, 2012, through June 30, 2014, in the Central Netherlands region for the design data cohort and from January 1 through December 31, 2015, in the Brabant region for the validation cohort. Data were analyzed from May 3, 2017, through July 19, 2018.A new prediction model was developed in the Central Netherlands region based on prehospital predictors associated with severe injury. Severe injury was defined as an Injury Severity Score greater than 15. A full-model strategy with penalized maximum likelihood estimation was used to construct a model with 8 predictors that were chosen based on clinical reasoning. Accuracy of the developed prediction model was assessed in terms of discrimination and calibration. The model was externally validated in the Brabant region.Using data from 4950 patients with trauma from the Central Netherlands region for the design data set (58.3% male; mean [SD] age, 47 [21] years) and 6859 patients for the validation Brabant region (52.2% male; mean [SD] age, 51 [22] years), the following 8 significant predictors were selected for the prediction model: age; systolic blood pressure; Glasgow Coma Scale score; mechanism criteria; penetrating injury to the head, thorax, or abdomen; signs and/or symptoms of head or neck injury; expected injury in the Abbreviated Injury Scale thorax region; and expected injury in 2 or more Abbreviated Injury Scale regions. The prediction model showed a C statistic of 0.823 (95% CI, 0.813-0.832) and good calibration. The cutoff point with a minimum specificity of 50.0% (95% CI, 49.3%-50.7%) led to a sensitivity of 88.8% (95% CI, 87.5%-90.0%). External validation showed a C statistic of 0.831 (95% CI, 0.814-0.848) and adequate calibration.The new prehospital trauma triage prediction model may lower undertriage rates to approximately 10% with an overtriage rate of 50%. The next step should be to implement this prediction model with the use of a mobile app for emergency medical services professionals.
Neurological Manifestations Due to Extramedullary Hematopoiesis in Greek Patients with Thalassemia Intermedia: Not Such a Rare Clinical Finding
Authors: Michael D. Diamantidis, Alexandra Kourakli, Efthymia Vlachaki, Despoina Pantelidou, Evgenia Verigou, Evangelos Alexiou, Fotios Girtovitis, Paraskevi Fotiou, Elisavet Grouzi, Argiris Symeonidis
Journal: Blood (2018)
Age as key factor for pattern, timing, and extent of distant metastasis in patients with cutaneous melanoma: A study of the German Central Malignant Melanoma Registry
Authors: Maximilian Gassenmaier, Ulrike Keim, Ulrike Leiter, Thomas K. Eigentler, Martin Röcken, Anja Gesierich, Rose K.C. Moritz, Lucie Heinzerling, Thomas Tüting, Uwe Wollina, Claus Garbe
Journal: Journal of the American Academy of Dermatology (2019)
Abstract 18658: Mechanical Stretch Activates Biased AT1R Signaling Through a Unique B-arrestin Conformation
Authors: Clarice Gareri, Joao A Paulo, Alem W Kashai, Jialu Wang, Kenji Hanada, Dean P Staus, Laura M Wingler, Steven P Gygi, Howard A Rockman
Journal: Circulation (2017)

Introduction: The angiotensin II Type 1 receptor (AT1R), a member of the GPCR family, is a crucial player in several cardiovascular diseases. Activated AT1Rs initiate a cascade of signaling pathway...
Single-Cell RNA Sequencing Reveals Compromised Immune Microenvironment in Precursor Stages of Multiple Myeloma
Authors: Oksana Zavidij, Nicholas Haradhvala, Tarek H Mouhieddine, Jihye Park, Romanos Pistofidis, Mairead Reidy, Daisy Huynh, Marzia Capelletti, Brianna Berrios, Mahshid Rahmat, Mark Bustoros, Chia-Jen Liu, Meng Xiao He, Yosef Maruvka, Bradley Rivotto, Kalvis Hornburg, Melissa Goldman, Eliezer Van Allen, Steven A McCarroll, Jamil Azzi, Gad Getz, Irene M. Ghobrial
Journal: Blood (2018)
Development of atopic sensitization in Finnish and Estonian children: A latent class analysis in a multicenter cohort
Authors: Felicitas Schmidt, Alexander J. Hose, Susanne Mueller-Rompa, Tabea Brick, Anu-Maaria Hämäläinen, Aleksandr Peet, Vallo Tillmann, Onni Niemelä, Heli Siljander, Mikael Knip, Juliane Weber, Erika von Mutius, Markus J. Ege
Journal: Journal of Allergy and Clinical Immunology (2019)
Measurement properties of Hospital Anxiety and Depression Scale used in atopic dermatitis in adults
Authors: Jonathan I. Silverberg, Joel Gelfand, David Margolis, Mark Boguniewicz, Luz S. Fonacier, Mitchell H. Grayson, Peck Y. Ong, Zelma Chiesa Fuxench, Eric L. Simpson
Journal: Journal of Allergy and Clinical Immunology (2019)
Abstract 18226: Temporary-Permanent Pacemakers - Why They Should be in Your Toolbox
Authors: Michael C Giudici, Ghanshyam P Shantha, Tyler Rasmussen
Journal: Circulation (2017)

Background: Temporary-permanent (T-P) pacemakers can serve as safe short-term pacing options in multiple clinical settings. We use this technique frequently and report our experience, outcomes, and...
Final Coverage Determination for Magnetic Resonance Imaging in Patients With Cardiac Devices
Authors: Michael U. Antonucci
Journal: JAMA Neurology (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
ColotypeR gene signature predicts response to cetuximab in colorectal cancer metastases.
Authors: Steven Allen Buechler, Yesim Gokmen-Polar, Sunil S. Badve
Journal: Journal of Clinical Oncology (2019)

599 Background: The consensus molecular subtypes (CMS1-4) partition primary colorectal cancer (CRC) into subgroups with distinct molecular characteristics. We previously reported a 20-genes ColotypeR-CMS signature that accurately defines CMS subtypes for primary CRC tumor samples. The utility of CMS subtyping in defining response to treatment of CRC metastases remains to be established. Here, we report the ability of ColotypeR scores to predict differential response to cetuximab among CMS subtypes in CRC metastases. Methods: The role of ColotypeR-CMS signature scores was assessed in CRC metastasis samples (GSE5851, N = 68, Affymetrix microarray) in predicting response to cetuximab. Progression-free survival (PFS) was the primary endpoint. The predictive significance of ColotypeR-CMS scores relative to KRAS mutation status was also studied using multivariate Cox proportional hazards models. Results: ColotypeR-CMS scores were computed in GSE5851 using the algorithm developed in primary tumor samples. Higher values of ColotypeR-CMS CMS2 score were significantly predictive of longer PFS (p = 5 x 10 -5 for the score test in Cox proportional hazards model; hazard ratio 0.20 (95%CI 0.09-0.44) in CRC metastases samples (GSE5851, N = 68) treated with cetuximab. PFS was independent of CMS1,3, 4 scores. KRAS wild type tumors had significantly longer PFS (p = 0.01; hazard ratio 0.49 (95%CI 0.28-0.86). In multivariate survival analysis, ColotypeR-CMS CMS2 score added to the significance of KRAS status (p = 0.012) and ColotypeR-CMS CMS2 score was predictive of longer PFS in KRAS wild type tumors (p = 0.009; hazard ratio 0.20 (95%CI 0.06-0.69)). Conclusions: We showed that in CRC metastasis samples, the ColotypeR CMS2 score was highly predictive of sensitivity to cetuximab treatment, while no increase in PFS was observed for higher values of CMS1, 3, 4 scores.
Abstract 199: Vasospastic Angina In A School Child Long After Kawasaki Disease
Authors: Yoshiyuki Kudo, Kenji Suda, Shintaro Kishimoto, Hironaga Yoshimoto, Toyojiro Matsuishi, Shigetaka Nishihara
Journal: Circulation (2015)

Though it has been already reported that the endothelial function was impaired in patients with a history of Kawasaki disease (KD) and coronary artery aneurysms, vasospastic angina has been rarely reported, especially in school child. A 13-year-old school child referred to us because of repeated chest pain on exercise and reverse redistribution in myocardial perfusion scan. His past history included KD at 2 years of age that was complicated by resistance to initial immunoglobulin treatment and he was left with coronary aneurysms; left main trunk (LMT) of 6.1mm, left anterior descending artery (LAD) of 6.0mm, and right coronary artery (RCA) of 6.0mm. He received oral warfarin treatment in addition to aspirin for 2 years and since then aspirin alone. Coronary angiogram at 7 years old showed LMT aneurysm of 6.1mm starting from orifice extending to bifurcation and regression of RCA aneurysm. He joined baseball club since 8 years old and has been doing well without any symptoms. In this summer, he started complain chest pain after 10 minutes of running 2-3 times a week that lasts for about 30 minutes. Though exercise stress test using treadmill did not show any abnormal electrocardiographic finding, stress myocardial perfusion scan using Thallous chloride-201Tl showed an area of reverse redistribution in the LAD territory. Baseline coronary angiogram at this time showed basically the same finding as that in the last study, intact RCA without stenosis and LMT aneurysm without any stenosis. However, provocative study using intra-coronary administration of 100 ug of acetylcholine, showed diffuse coronary artery spasm in all LCA branches and he indeed complained the same chest pain as that felt in exercise. In addition, intra-coronary administration of nitroglycerine completely reversed coronary spasm and chest pain. Conclusion: Vasospastic angina with chest pain can occurred in the school child with coronary artery aneurysms without coronary stenosis long after KD.
Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7RA cause receptor hypersensitivity
Authors: Livia Weijenborg Campos, Priscila Pini Zenatti, Leonardo Granato Pissinato, Gisele O. Libanio Rodrigues, Leonardo Luís Artico, Thais Rafael Guimarães, Leticia Fröhlich Archangelo, Leandro Martínez, Andrew J. Brooks, José Andrés Yunes
Journal: Blood (2019)
Abstract 11348: Effect of Apolipoprotein E Mimetic (AEM-28) on Lipoprotein Metabolism in Cynomolgus Monkeys
Authors: Dennis Goldberg, Susan Appt, Eric Morrel, Phillip Friden, Jay Kaplan, G. M Anantharamaiah, Thomas Register
Journal: Circulation (2014)

Introduction: AEM-28 combines the human HSPG receptor binding domain (aa 141-150) from Apo E with an 18 amino acid amphipathic helical lipid binding domain. AEM-28 inserts into the phospholipid surface of Apo B containing lipoproteins and targets them to the liver via Syndecan-1. This study examined the effects of 1 hour infusions of varying doses of AEM-28 on cholesterol in normo- and hypercholesterolemic cynomolgus monkeys. Methods: Normocholesterolemic monkeys were fed a diet containing 0.17 mg cholesterol/kcal. Hypercholesterolemic monkeys were fed a “Western Diet” containing 0.29 mg cholesterol/kcal. Male and female animals were dosed with 3, 6 or 12 mg/kg of AEM-28, in an ascending dose format. Results: AEM-28 reduced total cholesterol in a dose dependent manner. In normocholesterolemic monkeys, AEM-28 produced up to a 70% reduction within 2 hours of infusion, the effect plateauing at the 6 mg/kg dose. Plasma cholesterol was reduced by approximately 120 mg/dl and remained 15-25% below baseline for 7...
Disease trajectories in childhood atopic dermatitis: an update and practitioner's guide
Authors: A.D. Irvine, P. Mina‐Osorio
Journal: British Journal of Dermatology (2019)

Atopic dermatitis (AD) is a heterogeneous disease with a multifactorial aetiology and complex pathophysiology. This heterogeneity translates into different trajectories of disease progression with respect to severity, persistence and risk of development of atopic comorbidities. Determining which possible disease trajectories or comorbidities any individual child might develop is challenging in clinical practice. Tools that help identify paediatric patients at higher risk of disease progression would greatly aid clinicians.
Landscape of B cell immunity and related immune evasion in human cancers
Authors: Xihao Hu, Jian Zhang, Jin Wang, Jingxin Fu, Taiwen Li, Xiaoqi Zheng, Binbin Wang, Shengqing Gu, Peng Jiang, Jingyu Fan, Xiaomin Ying, Jing Zhang, Michael C. Carroll, Kai W. Wucherpfennig, Nir Hacohen, Fan Zhang, Peng Zhang, Jun S. Liu, Bo Li, X. Shirley Liu
Journal: Nature Genetics (2019)
Advantages of switching from non-standardized house dust extract to standardized house-dust mite in subcutaneous immunotherapy
Authors: Yuya Tanaka, Ikuo Okafuji, Tamaki Ito, Satoru Tsuruta, Saori Omae, Yuko Mitobe, Katsuyo Ohashi-Doi
Journal: Journal of Allergy and Clinical Immunology (2019)
Abstract 16796: Clinical Outcomes of Patients Treated With Idarucizumab for Dabigatran Reversal versus Four-factor Prothrombin Complex Concentrate for Warfarin Reversal
Authors: Ryan Clare, Avetis Hekimian, Reza Rafie, Cy Kim, Albert Y Shen, Mingsum Lee
Journal: Circulation (2017)

Introduction: Idarucizumab is an approved reversal agent of the direct thrombin inhibitor Dabigatran etexilate. There is limited information on the clinical outcomes of patients treated with idaruc...
Long-Term Clinical Effect Of Grass-Allergen Immunotherapy In Local Allergic Rhinitis, And Its Capacity to Modify The Natural Course Of The Disease.
Authors: Ibon Eguiluz-Gracia, Carmen Rondon, Gador Bogas, Paloma Campo, Francisca Gomez, Esther Barrionuevo, Ana Prieto del Prado, Natalia Cardenas, Ana Molina Bueno, Teresa Espino, Cristobalina Mayorga, M.J. Torres
Journal: Journal of Allergy and Clinical Immunology (2019)
A unique subset of PD-1+CXCR5-CD4+ T cells is involved in immunological mechanisms of IgG4-related disease
Authors: Ryuta Kamekura, Motohisa Yamamoto, Hayato Yabe, Hiromi Takaki, Kenichi Takano, Hiroki Takahashi, Hiroki Takahashi, Tetsuo Himi, Shingo Ichimiya
Journal: Journal of Allergy and Clinical Immunology (2019)
Use of video endoscopic inguinal lymphadenectomy (VEIL) in patients with urogenital malignancies: An observational study.
Authors: Raghunath S K, Sudhir Rawal, Samir Khanna
Journal: Journal of Clinical Oncology (2012)

e15101 Background: Surgical morbidity especially skin related necrosis is seen in 50% of patients following open radical inguinal lymphadenectomy in patients with urogenital malignancies. Inguinal lymphadenectomy helps in local control of disease and survival but had significant associated morbidity. We evaluated the post operative morbidity associated with minimally invasive video endoscopic Inguinal Lymphadenectomy (VEIL). Methods: Twenty two patients with urogenital malignancies who underwent thirty nine VEIL surgeries were evaluated for postoperative outcomes and morbidity. None of the patients required conversion to open surgery. Results: The mean operative time was 125 min, drain retention was 5.4 days, mean duration of postoperative stay was 3 days and a mean of 10.5 nodes were removed. 4.5% (1/22) developed skin flap necrosis, 4.5% (1/22) developed post operative venous bleeding that was controlled with dressing, 18.1% (4/22) developed lymphocoele that was resolved within 1-3 weeks with aspirations. Persistent drain output &gt;50ml/day was observed in 18.1 % (4/22) that was resolved by readjusting the drain. Histologically positive nodes were seen in 40.9% (9/22) of patients. Conclusions: These observations offer further support for using minimally invasive VEIL surgeries over open radical inguinal lymphadenectomy in patients with urogenital malignancies in reducing both surgical and skin related morbidity. Further randomized controlled studies are needed to validate these findings.
Abstract 15726: A Risk Model to Predict Need for ICU Utilization in Patients With NSTEMI
Authors: Alexander C Fanaroff, Anita Y Chen, Laine Thomas, Eric D Peterson, L K Newby, Ezra A Amsterdam, Mikhail N Kosiborod, James A De Lemos, Kirk N Garratt, Tracy Y Wang
Journal: Circulation (2016)

Introduction: Hospital rates of intensive care unit (ICU) utilization for patients presenting with non-ST elevation myocardial infarction (NSTEMI) vary widely, and no existing risk score has been d...
Growth factor signaling in pancreatic neuroendocrine tumor metastases.
Authors: Brenna Rheinheimer, Ronald Heimark, Tun Jie
Journal: Journal of Clinical Oncology (2019)

256 Background: Pancreatic neuroendocrine tumors (PanNETs) are among one of the fastest growing cancer diagnoses, yet clinical management for patients with metastatic disease is largely empirically based. Currently, surgical resection remains the only curative option; however, surgical resection of metastatic disease may not be feasible. Preliminary genomic analysis of primary PanNETs revealed a complex mutational landscape with four common oncogenic events; but, critical activation pathways of metastatic lesions have yet to be elucidated. Therefore, pan-genomic analysis of metastatic PanNETs is necessary to understand which genes/pathways are deregulated in PanNET metastases for potential therapeutic exploitation. Methods: We initiated a preliminary genomic sequencing study to evaluate mutations in a set of matched primary and metastatic PanNETs to determine genetic variants involved in metastasis to the liver. De-identified FFPE tumor samples were analyzed from patients who underwent surgical resection without receiving preoperative therapy. DNA was isolated and whole exome sequencing was performed using the Nextera Rapid Capture Exome Kit by Illumina on an Illumina HiSeq 2000/2500. The following criteria were used to define genetic variants: bidirectional, non-synonymous, clean mapping in IGV, ≥ 15X coverage, and an alternate allele frequency of 0.3 ≤ x ≤ 0.7. Results: All metastatic PanNETs were classified as WHO grade G2/G3 based on their KI-67 proliferation index. Each primary PanNET contained an average of 102 genetic variants while liver metastases showed an average of 124 genetic variants. MUFFINN and string analysis revealed that primary PanNETs contained enrichment for mutations involved in the PI3K/Akt and Ras signaling pathways while liver metastases showed enrichment for mutations involved in the MAPK and ErbB signaling pathways. Additionally, two-thirds of liver metastases contained somatic mutations in FGFR3. Conclusions: We have discovered novel pathways that have the potential to regulate pancreatic neuroendocrine tumor metastasis along with an innovative signaling pathway that may sustain metastatic growth and survival as well as exploitation for therapeutic potential.
The Netrin-1 - Neogenin Axis Regulates Hematopoietic Stem Cell Dormancy and Function with Implications for Stem Cell Ageing
Authors: Simon Renders, Pia Sommerkamp, Jasper Panten, Luisa Ladel, Katharina Schönberger, Daniel Klimmeck, Nina Cabezas-Wallscheid, Andreas Trumpp
Journal: Blood (2018)
Abstract P147: Glycemic Control and Weight in a Pediatric Diabetes Clinic Over Time: Gender Differences in Children With Type 1 Diabetes Between the Ages of 9-17 Years
Authors: Alexandra Bodan
Journal: Circulation (2017)

Research shows women with type 1 diabetes (T1D) face a disproportionately increased risk for development of cardiovascular disease (CVD) compared to men. We posit, adolescence may be a critical time period for CVD risk development. Our study examined the effects on gender differences in Hemoglobin A1c (HbA1c) and Body Mass Index z-score (BMIz) across puberty in children with T1D in a large pediatric diabetes specialty clinic. A total of 733 T1D children (M=355, F=378) aged 9-17 with a total of 21,534 visits from the Barbara Davis Center were suitable for this retrospective cohort study. To exam HbA1c and BMIz overtime by gender we used a linear mixed model with SAS version 9.4. HbA1c increased with age in both genders (p&lt;0.0001), but there was a greater increase in girls across adolescence (sex by age interaction, p&lt;0.0007). BMIz increased with age in girls only (sex by age interaction, p&lt;0.0001). Teenagers had worse glycemic control than younger children, and girls had worse glycemic control with greater obesity rates than boys. This gender difference in glycemic control and obesity during puberty may explain the increased CVD risk seen in women with T1D compared to men.
Significant In Vivo Sensitivity to Aurora Kinase Inhibition in TCF3-Hlf rearranged Acute Lymphoblastic Leukemia
Authors: Bill H. Chang, Jessica Leonard, Joelle Wolf, Michelle Degnin, Kyle Lenz, Beth Wilmot, Charles G. Mullighan, Mignon L. Loh, Stephen P. Hunger, Jeffrey W. Tyner, Brian J. Druker
Journal: Blood (2018)
Abstract 20382: Comparison of Outcomes After Rhythm or Rate Control Strategy for the New-Onset Atrial Fibrillation in Critically Ill Sepsis Patients Managed in the Medical Intensive Care Unit
Authors: Min Soo Cho, Gi-Byoung Nam, Yu Na Kim, Jongmin Hwang, Minsu Kim, Ji Hyun Lee, You Mi Hwang, Jun Kim, Kee-Joon Choi, You-Ho Kim
Journal: Circulation (2017)

Introduction: Data regarding effective rhythm or rate management for new onset atrial fibrillation (AF) in critically ill sepsis patients managed in the medical intensive care unit (MICU) are spars...