tbuckley/cabot-search huggingface dataset:
THU0608-HPR VALIDITY OF SIX MINUTE STEPPER TEST IN EVALUATION OF FUNCTIONAL EXERCISE CAPACITY IN PATIENTS WITH ANKYLOSING SPONDYLITIS
Authors: S. Bayram, N. G. Tore, F. Sarİ, D. C. Saraç, G. Gülsün, R. Bilici, A. Tufan, D. Oskay
Journal: Annals of the Rheumatic Diseases (2020)

Background: In most patients with ankylosing spondylitis (AS), exercise capacity decreases due to pulmonary dysfunction, chest wall restriction and peripheral muscle weakness. The six-minute walk test (6MWT) is a validated simple field, hence frequently used to evaluate exercise capacity. However, 6MWT has some limitations, especially the fact that it requires a corridor of at least 30 meters long to perform this test which can limit its use in some centers. Shorter corridors force patients to turn more frequently, slowing down the pace of walking that reduces potential walking distance. To overcome technical and spatial limitations, 6-minute stepper test (6MST) has been proposed to evaluate exercise capacity. In the literature 6MST has been suggested for a variety of diseases. Since, it requires only a limited amount of space and equipment and is feasible, easy to perform, well tolerated. Objectives: In the literature, there is no study in which 6MST is used to evaluate exercise capacities of patients with AS. Therefore, the aim of this study was to evaluate validity of 6MST in AS population in comparison to 6MWT. Methods: 6MWT and 6MST were performed in 51 patients with AS (52.26±13.33 years, 30F/21M). Demographic and clinical characteristics were recorded. Functional exercise capacity was evaluated using 6MWT and 6MST. The total distance of 6MWT was compared to the total number of steps of 6MST. Before, during and after 6MWT and 6MST, heart rate (HR), oxygen saturation (SpO 2 ), breathing frequency (BF), blood pressure (BP), dyspnea and fatigue were assessed using modified Borg scale. Results: The number of steps on the 6MST was significantly correlated with the distance of the 6MWT (r=0.61, p&lt;0.0001). Dyspnea (p=0.04) and leg fatigue (p&lt;0.0001) was significantly higher in 6MST than in 6MWT. HR, SpO 2 , BF, BP and fatigue were similar in both 6MST and 6MWT. Conclusion: The 6MST is a valid test to evaluate exercise capacity in patients with AS. It is also an appropriate alternative to the 6MWT for determining exercise capacity when the 6MWT is not feasible due to technical restrictions. The 6MST can be proposed as a new exercise capacity evaluation tool in AS, as it is valid, reliable, portable and inexpensive. References: [1]van der Esch, Martin, et al. Respiratory muscle performance as a possible determinant of exercise capacity in patients with ankylosing spondylitis. Australian Journal of Physiotherapy, 2004;50(1):41-46. [2]ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med. 2002;166(1):111–117. [3]Grosbois JM, Riquier C, Chehere B, et al. Six-minute stepper test: a valid clinical exercise tolerance test for COPD patients. Int J Chron Obstruct Pulmon Dis. 2016;11:657–663. Disclosure of Interests: None declared
RGS10 and RGS18 differentially limit platelet activation, promote platelet production, and prolong platelet survival
Authors: Daniel DeHelian, Shuchi Gupta, Jie Wu, Chelsea Thorsheim, Brian Estevez, Matthew Cooper, Kelly Litts, Melissa M. Lee-Sundlov, Karin M. Hoffmeister, Mortimer Poncz, Peisong Ma, Lawrence F. Brass
Journal: Blood (2020)
Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation
Authors: Yunpeng Zhao, Cheng Qiu, Wenhan Wang, Jiangfan Peng, Xiang Cheng, Yangtao Shangguan, Mingyang Xu, Jiayi Li, Ruize Qu, Xiaomin Chen, Suyi Jia, Dan Luo, Long Liu, Peng Li, Fengjin Guo, Krasimir Vasilev, Liang Liu, John Hayball, Shuli Dong, Xin Pan, Yuhua Li, Linlin Guo, Lei Cheng, Weiwei Li
Journal: Theranostics (2020)

Background: Intervertebral disc (IVD) degeneration is a common degenerative disease that can lead to collapse or herniation of the nucleus pulposus (NP) and result in radiculopathy in patients. Methods: NP tissue and cells were isolated from patients and mice, and the expression profile of cortistatin (CST) was analysed. In addition, ageing of the NP was compared between 6-month-old WT and CST-knockout (CST-/-) mice. Furthermore, NP tissues and cells were cultured to validate the role of CST in TNF-α-induced IVD degeneration. Moreover, in vitro and in vivo experiments were performed to identify the potential role of CST in mitochondrial dysfunction, mitochondrial ROS generation and activation of the NLRP3 inflammasome during IVD degeneration. In addition, NF-κB signalling pathway activity was tested in NP tissues and cells from CST-/- mice. Results: The expression of CST in NP cells was diminished in the ageing- and TNF-α-induced IVD degeneration process. In addition, compared with WT mice, aged CST-/- mice displayed accelerated metabolic imbalance and enhanced apoptosis, and these mice showed a disorganized NP tissue structure. Moreover, TNF-α-mediated catabolism and apoptosis were alleviated by exogenous CST treatment. Furthermore, CST inhibited mitochondrial dysfunction in NP cells through IVD degeneration and suppressed activation of the NLRP3 inflammasome. In vitro and ex vivo experiments indicated that increased NF-κB pathway activity might have been associated with the IVD degeneration observed in CST-/- mice. Conclusion: This study suggests the role of CST in mitochondrial ROS and activation of the NLRP3 inflammasome in IVD degeneration, which might shed light on therapeutic targets for IVD degeneration.
High dietary acid load is associated with nonalcoholic fatty liver disease (NAFLD) in a large population-based study : The Rotterdam Study
Authors: L.J. Alferink, J.C. Kiefte-De Jong, N. Erler, J.D. Schoufour, E.J. Hoorn, Ikram, H.L. Janssen, H.J. Metselaar, O.H. Franco, S.D. Murad
Journal: Hepatology (2017)
Effect of Aerobic Exercise on Blood Pressure: A Meta-Analysis of Randomized Controlled Trials
Authors: Seamus P Whelton, Ashley Chin, Jiang He
Journal: Circulation (2001)

P97 Physical activity has been associated with reduced blood pressure in observational epidemiological studies and individual clinical trials. We conducted a meta-analysis of randomized controlled trials to determine the effect of aerobic exercise on blood pressure. We searched English-language articles published before June 2000. Thirty-nine randomized controlled trials (1,418 subjects) in which aerobic exercise was the only difference between the intervention and control groups were selected for the analysis. Employing a standardized protocol and data extraction form, two of the investigators independently abstracted data on study design, sample size, participant characteristics, type of intervention, follow-up duration, and treatment outcomes. Using a random-effects model, data from each trial was pooled and weighted by the inverse of its variance. Aerobic exercise was associated with a significant reduction in mean (95% confidence interval) systolic and diastolic blood pressure of -4.84 mm Hg (-3.30 to -6.37) and -3.12 mm Hg (-2.10 to -4.14), respectively. The reduction in blood pressure was similar in hypertensive and normotensive participants. This meta-analysis indicates that aerobic exercise reduces blood pressure in hypertensive and normotensive populations. An increase in aerobic physical activity should be considered as an important component of lifestyle modification for the prevention and treatment of high blood pressure.
AB0270 THE IMPACT OF DIABETES MELLITUS ON OUTCOMES OF RHEUMATOID ARTHRITIS AT 5-YEAR FOLLOW-UP: RESULTS FROM A MULTI-ETHNIC ASIAN COHORT IN SINGAPORE
Authors: C. Xu, K. P. Leong, M. Y. Yong, E. T. Koh
Journal: Annals of the Rheumatic Diseases (2020)

Background: Both diabetes mellitus (DM) and rheumatoid arthritis (RA) are prevalent diseases and represent the leading causes of disability and mortality worldwide. Systemic chronic inflammation is recognized as the underlying etiology of a variety of diseases, including DM and RA [1]. Additionally, cardiovascular and musculoskeletal complications from DM may influence the outcomes of RA patients. Objectives: To investigate the impact of DM on outcomes of RA patients. Methods: This is a cross-sectional study including 583 RA patients with 5 years’ history after diagnosis in Tan Tock Seng Hospital RA registry, Singapore from 2001 to 2013. Information related to demographics, serologies, clinical features, comorbidities, and outcomes was collected. Independent t-test or Mann-Whitney U test was used to compare continuous quantitative data, while Pearson Chi-square or Fisher Exact test for categorical data. With adjustment for age, gender, ethnicity, smoking and comorbidities, multivariate regressions were performed to analyze the impact of DM on outcomes of RA patients. Results: DM is more prevalent in Malay and Indian patients than Chinese patients with RA (26%, 24% and 11% respectively, p = 0.005). There is no difference of disease activity between DM and non DM patients. There is a tendency that non diabetic RA patients use more methotrexate ( p = 0.052) and leflunomide ( p = 0.058). Diabetic RA patients are in higher risk of poor American College of Rheumatology (ACR) functional status ( p = 0.009), knee arthroplasty ( p &lt; 0.001) and admissions ( p = 0.006). Adjusted for age, gender, ethnicity, smoking and comorbidities, multivariate regression analyses showed a trend of poor function status for diabetic RA patients, i.e. ACR functional status (adjusted odds ratio [aOR]: 1.802, 95% confidence interval [CI]: 0.968 – 3.353, p = 0.063) and median Health Assessment Questionnaire (HAQ) (β coefficient value: 0.129, 95% CI: -0.010 – 0.267, p = 0.068), and higher risk for knee arthroplasty for diabetic RA patients (aOR: 3.480, 95% CI: 1.016 – 11.920, p = 0.047). Conclusion: This is the first report on the impact of DM on RA outcomes in a long term follow-up RA registry in a multiethnic Asian society. References: [1]Furman, D., Campisi, J., Verdin, E. et al. Chronic inflammation in the etiology of disease across the life span. Nat Med 25, 1822–1832 (2019). Acknowledgments: TTSH Rheumatoid Arthritis Study Group Disclosure of Interests: None declared
Prognosis of Patients With Stage III Melanoma According to American Joint Committee on Cancer Version 8: A Reassessment on the Basis of 3 Independent Stage III Melanoma Cohorts
Authors: Claus Garbe, Ulrike Keim, Stefan Suciu, Teresa Amaral, Thomas K. Eigentler, Anja Gesierich, Axel Hauschild, Lucie Heinzerling, Felix Kiecker, Dirk Schadendorf, Rudolf Stadler, Cord Sunderkötter, Thomas Tüting, Jochen Utikal, Uwe Wollina, Christos C. Zouboulis, Ulrich Keilholz, Alessandro Testori, Peter Martus, Ulrike Leiter, Alexander M. M. Eggermont
Journal: Journal of Clinical Oncology (2020)

Three new therapies have been approved recently for the adjuvant treatment of stage III melanoma, substantially reducing the risk of tumor recurrences. This study evaluates 3 independent data sets to clarify the survival probabilities of patients with stage III melanoma.The Central Malignant Melanoma Registry (CMMR) evaluated 1,553 patients with a primary diagnosis of stage III melanoma from 2000 to 2012. Studies from the European Organisation for Research and Treatment of Cancer (EORTC), of 573 patients in the observation arm of the 18991 study and 445 patients in the placebo arm of the 18071 study, were evaluated as reference cohorts. The survival outcomes were compared with the published American Joint Committee on Cancer version 8 (AJCCv8) stage III survival data.For the CMMR stage III cohort versus the AJCCv8 cohort, the melanoma-specific survival (MSS) rates at 5 years were 67% versus 77%, and at 10 years were 56% versus 69%, respectively. For stage IIIA, the MSS rates at 5 years were 80% versus 93%, and at 10 years were 71% versus 88%; for stage IIIB, the MSS rates at 5 years were 75% versus 83%, and at 10 years were 61% versus 77%. The MSS rates of the EORTC studies either overlapped with or were lower than, the CMMR data.The MSS rates in the CMMR and EORTC cohorts over the entire stage III are less favorable than those published in AJCCv8. This is particularly true for substages IIIA and IIIB.
AB0549 THE RELEVANCE OF AORTIC STENOSIS AND OUTCOME OF TAVI PROCEDURE FOR VALVE REPAIR IN SCLERODERMA PATIENTS
Authors: A. Balbir-Gurman, Y. Braun-Moscovici
Journal: Annals of the Rheumatic Diseases (2020)

Background: Patients with systemic sclerosis (SSc) are at risk for developing aortic valve changes. The prevalence of aortic valve stenosis (AS) in SSc patients is unknown. Previously, patients with AS were treated with valve replacement; in recent years, Trans Catheter Aortic Valve Implantation (TAVI) is widely used in general population. The safety of Trans Catheter Aortic Valve Implantation (TAVI) in SSc has not been assessed. Objectives: A retrospective study on aortic valve pathology and treatments including TAVI performance. Methods: We reviewed 374 records of SSc patients at our site EUSTAR cohort and extracted cases with reported AS confirmed by ECHO cardiography and heart catheterization. Results: We found data on 13 (3.4%) patients with AS: 12 females (92.3%); mean age 70.3 (SD 7.7) years, disease duration 15.4 (SD 6.3) years. Ten patients had limited SSc (76.9%, all cared anti-centromere antibodies) and 3 diffuse SSc (1 patient had RNAP3 and 2 had anti-topoisomerase antibodies); 5 (38.5%) patients had significant coronary disease (3 underwent CABG, 2 had several PTCA). Eight (61.5%) patients dead during years 2004 - 2019. Aortic valve replacement was performed in 5 patients (4 – metal and 1 – biological); 2 patients did not undergo AS repair due to impaired general condition; 6 patients underwent TAVI between January 2013 and December 2019 (5 at Rambam Cardiology Institute). All SSc patients underwent trans femoral TAVI under conscious sedation. The procedure was successful in all patients. The length of hospitalization was 5-14 days (mean 8.2 days); 3 (50%) patients needed pacemaker implantation (they did not have previous conduction abnormalities). The follow-up duration after TAVI was between 5 and 67 months (mean 20.7). During follow-up one patient developed bacterial endocarditis related to pacemaker device two months after the procedure; the event resolved after removing the device and according antibiotics treatment; the same patient had transient ischemic attack two years later and another pacemaker implantation 3 years later due to complete AV block. One patients dead from urosepsis 11 months after TAVI, the death was not related to procedure. One patient developed anemia due to large hematoma after the procedure. Conclusion: Screening for aortic valve pathology is essential as AS is not rare in SSc patients especially in those with long standing limited disease and positivity to centromere antibodies. AS in SSc patients may be associated with clinically significant coronary artery disease. TAVI was safe in our SSc patients without in-hospital mortality and benign long-term outcome. Disclosure of Interests: Alexandra Balbir-Gurman Consultant of: Novartis, Yolanda Braun-Moscovici: None declared
Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics
Authors: Jonas Bovijn, Kristi Krebs, Chia-Yen Chen, Ruth Boxall, Jenny C. Censin, Teresa Ferreira, Sara L. Pulit, Craig A. Glastonbury, Samantha Laber, Iona Y. Millwood, Kuang Lin, Liming Li, Zhengming Chen, Lili Milani, George Davey Smith, Robin G. Walters, Reedik Mägi, Benjamin M. Neale, Cecilia M. Lindgren, Michael V. Holmes
Journal: Science Translational Medicine (2020)

SOST variants that mimic therapeutic inhibition of sclerostin for osteoporosis are associated with higher risk of cardiovascular disease.
Abstract A07: Improved prognosis of HPV-positive oropharyngeal cancers is associated with a suppression of TGF-β-mediated immune evasion
Authors: Anthony Bolyos, Pinaki Bose
Journal: Clinical Cancer Research (2020)

Abstract Among head and neck squamous carcinoma (HNSC), human papilloma virus (HPV)-driven tumors are known to enjoy more favorable prognostic outcomes compared to non-HPV-driven disease. This is especially true of HPV-positive oropharyngeal squamous cell carcinoma (OPSCC), which is associated with significantly improved outcomes compared to HPV-positive non-OPSCC and HPV-negative HNSC. Previous reports have suggested that increased immune infiltration and expression of the estrogen receptor α (ERα) may play a role in conferring improved prognosis to HPV-positive OPSCC. However, the underlying signaling pathways specifically driven by HPV in the oropharynx have remained elusive. Here we analyzed HPV-positive OPSCC and non-OPSCC tumors from The Cancer Genome Atlas (TCGA) and found that HPV-positive OPSCC is associated with significantly improved overall and disease-specific survival and progression-free interval compared to HPV-positive non-OPSCC. Among HPV-positive HNSC, we observed a distinct separation of OPSCC from non-OPSCC tumors based on unsupervised clustering of gene expression, microRNA, and methylation profiling data. Separation based on anatomic site was not observed among HPV-negative HNSC, suggesting that common biology drives the carcinogenesis of HPV-negative HNSC across subsites. In line with a recent report that ERα mRNA expression is elevated HPV-positive OPSCC, we found significantly higher ERα mRNA levels in HPV-positive OPSCC compared to HPV-positive non-OPSCC, where ERα mRNA expression mirrored that in HPV-negative HNSC. We also found that HPV induces downregulation of TGF-β signaling and extracellular matrix (ECM)-associated genes while upregulating a T-cell and dendritic cell-associated immune response signature in an OPSCC-specific manner. Our analyses suggest that HPV induces downregulation of TGF-β signaling and ECM components in OPSCC to improve immune access to these tumors, facilitating tumor clearance and improved patient survival. These findings are in line with our recent report establishing TGF-β-mediated immunosuppression through ECM deregulation and its negative effect on patient prognosis. Citation Format: Anthony Bolyos, Pinaki Bose. Improved prognosis of HPV-positive oropharyngeal cancers is associated with a suppression of TGF-β-mediated immune evasion [abstract]. In: Proceedings of the AACR-AHNS Head and Neck Cancer Conference: Optimizing Survival and Quality of Life through Basic, Clinical, and Translational Research; 2019 Apr 29-30; Austin, TX. Philadelphia (PA): AACR; Clin Cancer Res 2020;26(12_Suppl_2):Abstract nr A07.
Cultured corneal keratocyte apoptosis induced by UV radiation is prevented by ubiquinone Q-10
Authors: G Carella, Sergio Capaccioli, Rosario Brancato, Martino Donnini, Andrea Lapucci, Laura Papucci, Nicola Schiavone, Marco Cutri, Lucia Formigli, Sz Orlandini
Journal: Ophthalmology (2000)
Cross‐sectional biomarker comparisons in asthma monitoring using a longitudinal design: The eNose premise
Authors: Mahmoud I. Abdel‐Aziz, Rianne de Vries, Ariana Lammers, Binbin Xu, Anne H. Neerincx, Susanne J. H. Vijverberg, Yennece W. F. Dagelet, Aletta D. Kraneveld, Urs Frey, René Lutter, Peter J. Sterk, Anke H. Maitland‐van der Zee, Anirban Sinha
Journal: Allergy (2020)

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AB1329-HPR THE CURRENT STATUS AND ASSOCIATED FACTORS OF FATIGUE IN CHINESE PATIENTS WITH GOUT
Authors: J. Guo, W. Zhou, M. He, Z. Gu, C. Dong
Journal: Annals of the Rheumatic Diseases (2020)

Background: Fatigue of chronic diseases has been paid more and more attention. but the status of fatigue in gout patients has not been reported all the world[1]. Objectives: In the absence of previous studies, our study aims to investigate the fatigue status, explore the potential predictors of fatigue and the effects of fatigue on health-related quality of life (HRQoL) among Chinese gout patients. Methods: This cross-sectional study was conducted from the Affiliated Hospital of Nantong University. A series of questionnaires were applied: Fatigue Scale-14 (FS-14), the 10 cm visual analog scale (VAS), the Patient Health Questionnaire (PHQ-9), the Generalized Anxiety Disorder questionnaire (GAD-7), the Pittsburgh Sleep Quality Index (PSQI), Health Assessment Questionnaire(HAQ), the Short Form 36 health survey (SF-36). Laboratory examinations were taken to obtain some biochemical indicators. Independent samples t-test, Mann–Whitney U-test, Chi-square analysis, Pearson /Spearman correlation, Stepwise linear regression and binary logistic regression were used to analyze the data. Results: 411 gout patients were included in this study. Among them, more than 50% patients reported physical fatigue in FS-14, severe disease, poor psychological status and reduced HRQoL were associated with fatigue. Multiple stepwise linear regression and binary logistic regression were applied and showed that pain, sleep quality, anxiety, depression and functional disorder were the potential predictors of fatigue. In addition, we found that the more severe the fatigue, the lower the patient’s HRQoL. Conclusion: Fatigue among gout patients is exceedingly common. The results of this study suggested that rheumatologists should pay closely attention to gout patients who suffer from serious fatigue, especially those with pain, poorer sleep quality, anxiety, depression and functional disorder. References: [1]Henry, A., Tourbah, A., Camus, G., Deschamps, R., Mailhan, L., Castex, C., Gout, O. &amp; Montreuil, M. (2019) Anxiety and depression in patients with multiple sclerosis: The mediating effects of perceived social support, Multiple sclerosis and related disorders. 27, 46-51. Disclosure of Interests: None declared