tbuckley/cabot-search huggingface dataset:
L'exploration de la muqueuse digestive en tomografie par cohérence optique plein champ (FF-OCT): un outil prometteur pour l'étude de la barrière digestive
Authors: L Quénéhervé, R Olivier, JF Mosnier, C Brochard, C Bossard, M Neunlist, E Coron
Journal: Endoscopy (2019)

La tomografie par cohérence optique Plein Champ (ou FF-OCT) est une technique d'imagerie non invasive des milieux biologiques reposant sur l'interférométrie et permettant l'acquisition d'images dynamiques de tissus ex vivo à l'échelle cellulaire. Malgré un intérêt potentiel majeur dans la compréhension des maladies digestives, cette technique a été très peu évaluée en Gastroentérologie. L'objectif de cette étude était de démontrer la faisabilité d'obtention d'images d'intérêt par la FF-OCT pour l'étude de la barrière intestinale digestive normale.
USE OF SELF-EXPANDING METALLIC STENTS IN THE MANAGEMENT OF ESOPHAGEAL LEAKS AFTER SURGERY
Authors: E Iglesias Jorquera, J Egea Valenzuela, A Serrano Jimenez, G Carrilero Zaragoza, A Ortega Sabater, E Sánchez Velasco, D Ruiz de Angulo, V Munitiz, P Parrilla Paricio, F Alberca de las Parras
Journal: Endoscopy (2019)

Esophageal leaks are severe complications after surgery. The use of endoscopic self-expanding metallic stents is a valid option. Our aim was to evaluate the usefulness of the stents in a third level referral center.
ERCP TISSUE SAMPLING FROM COMMON BILE DUCT STRICTURES: BRUSH CITOLOGY AND INTRADUCTAL FORCEPS BIOPSY – WHICH ONE SHOULD I PERFORM FIRST?
Authors: N Zaragoza Velasco, M Albuquerque Miranda, JM Miñana, M Figa Francesch, A Vargas García, MJ Domper Arnal, R Ballester Clau, G Torres Vicente, IM Salas, JMR Espinet, F González-Huix i lladó
Journal: Endoscopy (2019)

The accuracy of brush citology (BC) plus intraductal forceps biopsy (IFB) in diagnosis of common bile duct strictures (CBDs) is about 60%. It is unknown whether the order of perform both methods improves accuracy.
GENDER-SPECIFIC DIFFERENCE IN HISTOLOGY OUTCOMES ACCORDING TO POLYP SHAPE IN SCREENING COLONOSCOPIES
Authors: B Majcher, D Penz, E Kammerlander-Waldmann, A Hinterberger, A Szymanska, D Pammer, A Asaturi, M Trauner, M Ferlitsch
Journal: Endoscopy (2019)

Predictions about histology can be made due to polyp's size, localization and shape. As influence of size and localization have been already shown in many studies (Lieberman D et al, Gastroenterology 2008), our aim of the study was to evaluate probabilities for type of histology according to different polyp shapes and whether it shows distinction between men and women.
Real world patterns of use and value of pertuzumab in the treatment of HER2+ metastatic breast cancer in Singapore: The National Cancer Centre Singapore experience
Authors: S. Rahardja, R.Y.C.S. Tan, R. Sultana, F.L. Leong, E. Lim
Journal: Annals of Oncology (2019)

Background: There are currently few reports on the pattern of use and value of Pertuzumab in the real-world setting. Our study describes the clinical efficacy and treatment costs of Pertuzumab in HER2-positive metastatic breast cancer (MBC) treated in a tertiary cancer centre in Singapore. Methods: A retrospective study of consecutive HER2-positive MBC patients seen from 1st January 2011 to 31st December 2017 at National Cancer Centre Singapore (NCCS) was conducted. Demographic and clinical data were extracted from medical records. Clinical characteristics of patients who received Pertuzumab were compared with those who did not. Billing data during the treatment period of all patients was also collected. Results: A total of 329 patients were included: Median age of diagnosis was 58 years where 196 (64.5%) were of Chinese ethnicity. Invasive Ductal Carcinoma (IDC) was diagnosed in 268 (88.2%) patients, and 168 (55.3%) had estrogen receptor (ER) and/or progesterone receptor (PR) positive disease. Bone was the most common site of metastasis which was observed in 167 (54.9%) of patients, while 225 (68.4%) patients had visceral metastases. Forty-nine (14.9%) patients received Pertuzumab, 30 of whom received it as first-line therapy. With an median duration of follow-up of 21 months, there was a statistically significant difference in the median overall survival (OS): 52 months (95% CI 32.7-71.3) versus 33 months (95% CI 28.5-37.5) (Log Rank p = 0.013) for Pertuzumab versus non-Pertuzumab groups, respectively. Two (4.1%) patients in the Pertuzumab group experienced grade 3 (G3) cardiotoxicity. The median treatment cost of the Pertuzumab group was SGD$152,283 compared to SGD$63,130 for the non-Pertuzumab group. The median percentage of total chemotherapy costs per patient in the Pertuzumab group spent on Pertuzumab was 49.8%. Conclusions: This study shows that pertuzumab use in the treatment of metastatic breast cancer is associated with a significant improvement in survival and a low incidence of serious cardiotoxicities. However, the proportionate cost of Pertuzumab therapy remains high and further cost-effectiveness studies should be conducted. Legal entity responsible for the study: National Cancer Centre Singapore. Funding: Has not received any funding. Disclosure: All authors have declared no conflicts of interest.
Abstract 13306: The Pediatric Acute Care Cardiology Collaborative (PAC3) Hospital Acute Care Unit Survey: Results and Implications
Authors: Amanda Hoerst, Adnan Bakar, Steven Cassidy, Martha Clabby, Erica Del Grippo, Margaret Graupe, Ashraf Harahsheh, Anthony M Hlavacek, Stephen A Hart, Alaina K Kipps, Nicolas Madsen, Dora D O’Neil, Sonali S Patel, Courtney M Strohacker, Ronn E Tanel
Journal: Circulation (2018)

Introduction: The Pediatric Acute Care Cardiology Collaborative (PAC3) was established in 2014 to understand systems and clinical practices in cardiac care delivered outside the intensive care unit...
Paraneoplastic phenomenon in mesothelioma
Authors: Ali Bin Waqar, Daniel Menzies, Mared Casey, Mark Doran
Journal: Thorax (2019)

A 71-year-old man presented with breathlessness and visual disturbance. On examination of the chest, he had signs suggestive of a right-sided pleural effusion and a neurological examination yielded conjugate vertical gaze palsy. Subsequent investigations revealed pleural thickening and mesothelioma. His anti-Ma2 antibodies were positive indicating a paraneoplastic syndrome as the cause of the vertical gaze palsy.
Medical associates: junior doctors oppose professional equivalency
Authors: Elisabeth Mahase
Journal: BMJ (2019)

Junior doctors have voted to “actively oppose” medical associate professionals (MAPs) being treated equally to them when it comes to medical staffing.1 MAPs include physician associates and advanced critical care practitioners.

After a heated debate at the BMA’s junior doctors conference on Saturday 18 May, delegates also voted to oppose MAPs being able to sit postgraduate medical exams and to become senior decision makers in healthcare teams.

Several other motions concerning the growing role of MAPs were passed. These included a call for the BMA to be involved in the further development of the role of physician associates …
SUCCESSFUL CLOSURE OF A RECTAL FISTULA OF CROHN'S DISEASE USING ENDOSCOPIC SUBMUCOSAL DISSECTION OF THE FISTULOUS TRACT COMBINED WITH AN OVER THE SCOPE CLIP
Authors: T Wallenhorst, M Pioche, J Jacques
Journal: Endoscopy (2019)

Luminal fistulas of Crohn's disease represent a therapeutic challenge, with frequent use of surgery despite the advent of biologics. There is no reported case of effective endoscopic treatment in the literature. Submucosal dissection of the fistulous orifice combined with clip closure has been described as effective for two cases of chronic oeso-tracheal fistulas and one case of fistula on rectal anastomosis. We report the first success of this technique, to treat a refractory rectal fistula of Crohn's disease.
Derek Melville Prinsley
Authors: Peter Prinsley
Journal: BMJ (2019)

Derek Melville Prinsley was among the last the of the generation of doctors who served in the Royal Air Force during the second world war and among the last of the doctors who qualified before the start of the National Health Service (NHS) He became a pioneer of geriatric medicine, and his career spanned medical practice in three continents and more than 50 years of active clinical practice.

Derek Prinsley was born in West Hartlepool, the son of Abraham and Ada Prinsky. His father was a jeweller and tobacconist, and his mother, who was photographed in flapper dresses, was the first woman to drive a car in the town.

Medical students were fast tracked during the war and Derek qualified at the age of 21 at Newcastle as probably one of the youngest doctors in the country. He joined the RAF and served in UK airbases and in the Middle East in Aden as squadron leader and medical officer.

Ships transporting wounded servicemen from the Far East would call at the port of Aden and be exchanged for recuperating patients well enough to sail for home. Derek’s autobiography, entitled New Ideas for Old Concerns , describes the negotiation that would take place in the …
Keratinocyte footprint assay discriminates antilaminin‐332 pemphigoid from all other forms of pemphigoid diseases
Authors: F. Giurdanella, A.M. Nijenhuis, G.F.H. Diercks, M.F. Jonkman, H.H. Pas
Journal: British Journal of Dermatology (2019)

BackgroundAntilaminin‐332 mucous membrane pemphigoid is a chronic severe pemphigoid disease characterized by autoantibodies to laminin‐332. At present no commercial assay is available to demonstrate antilaminin‐332 antibodies, and diagnosis relies on in‐house techniques with limited sensitivities.
Corrigendum to “Long-acting hydrogel/microsphere composite sequentially releases dexmedetomidine and bupivacaine for prolonged synergistic analgesia” [Biomaterials 181 (2018) 378–391]
Authors: Wenjing Zhang, Weiguo Xu, Cong Ning, Mingqiang Li, Guoqing Zhao, Weiqian Jiang, Jianxun Ding, Xuesi Chen
Journal: Biomaterials (2019)
Life-Long AAV-Mediated CRISPR Genome Editing in Dystrophic Heart Improves Cardiomyopathy without Causing Serious Lesions in mdx Mice
Authors: Li Xu, Yeh Siang Lau, Yandi Gao, Haiwen Li, Renzhi Han
Journal: Molecular Therapy (2019)

Previous studies from others and us have demonstrated that CRISPR genome editing could offer a promising therapeutic strategy to restore dystrophin expression and function in the skeletal muscle and heart of Duchenne muscular dystrophy (DMD) mouse models. However, the long-term efficacy and safety of CRISPR genome-editing therapy for DMD has not been well established. We packaged both SaCas9 and guide RNA (gRNA) together into one AAVrh.74 vector, injected two such vectors (targeting intron 20 and intron 23, respectively) into mdx pups at day 3 and evaluated the mice at 19 months. We found that AAVrh.74-mediated life-long CRISPR genome editing in mdx mice restored dystrophin expression and improved cardiac function without inducing serious adverse effects. PCR analysis and targeted deep sequencing showed that the DSBs were mainly repaired by the precise ligation of the two cut sites. Serological and histological examination of major vital organs did not reveal any signs of tumor development or other deleterious defects arising from CRISPR genome editing. These results support that in vivo CRISPR genome editing could be developed as a safe therapeutic treatment for DMD and potentially other diseases.
Clonal Selection with RAS Pathway Activation Mediates Secondary Clinical Resistance to Selective FLT3 Inhibition in Acute Myeloid Leukemia
Authors: Christine M. McMahon, Timothy Ferng, Jonathan Canaani, Eunice S. Wang, Jennifer J.D. Morrissette, Dennis J. Eastburn, Maurizio Pellegrino, Robert Durruthy-Durruthy, Christopher D. Watt, Saurabh Asthana, Elisabeth A. Lasater, RosaAnna DeFilippis, Cheryl A.C. Peretz, Lisa H.F. McGary, Safoora Deihimi, Aaron C. Logan, Selina M. Luger, Neil P. Shah, Martin Carroll, Catherine C. Smith, Alexander E. Perl
Journal: Cancer Discovery (2019)

Abstract Gilteritinib is a potent and selective FLT3 kinase inhibitor with single-agent clinical efficacy in relapsed/refractory FLT3-mutated acute myeloid leukemia (AML). In this context, however, gilteritinib is not curative, and response duration is limited by the development of secondary resistance. To evaluate resistance mechanisms, we analyzed baseline and progression samples from patients treated on clinical trials of gilteritinib. Targeted next-generation sequencing at the time of AML progression on gilteritinib identified treatment-emergent mutations that activate RAS/MAPK pathway signaling, most commonly in NRAS or KRAS. Less frequently, secondary FLT3-F691L gatekeeper mutations or BCR–ABL1 fusions were identified at progression. Single-cell targeted DNA sequencing revealed diverse patterns of clonal selection and evolution in response to FLT3 inhibition, including the emergence of RAS mutations in FLT3-mutated subclones, the expansion of alternative wild-type FLT3 subclones, or both patterns simultaneously. These data illustrate dynamic and complex changes in clonal architecture underlying response and resistance to mutation-selective tyrosine kinase inhibitor therapy in AML. Significance: Comprehensive serial genotyping of AML specimens from patients treated with the selective FLT3 inhibitor gilteritinib demonstrates that complex, heterogeneous patterns of clonal selection and evolution mediate clinical resistance to tyrosine kinase inhibition in FLT3-mutated AML. Our data support the development of combinatorial targeted therapeutic approaches for advanced AML. See related commentary by Wei and Roberts, p. 998. This article is highlighted in the In This Issue feature, p. 983
POEMS Syndrome: 2019 Update on diagnosis, risk‐stratification, and management
Authors: Angela Dispenzieri
Journal: American Journal of Hematology (2019)

Abstract Disease Overview Polyneuropathy, organomegaly, endocrinopathy, M‐protein, skin changes (POEMS) syndrome is a paraneoplastic syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyradiculoneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease. Minor features include organomegaly, endocrinopathy, characteristic skin changes, papilledema, extravascular volume overload, and thrombocytosis. Diagnoses are often delayed because the syndrome is rare and can be mistaken for other neurologic disorders, most commonly chronic inflammatory demyelinating polyradiculoneuropathy. POEMS syndrome should be distinguished from the Castleman disease variant of POEMS syndrome, which has no clonal PCD and typically little to no peripheral neuropathy but has several of the minor diagnostic criteria for POEMS syndrome. Diagnosis The diagnosis of POEMS syndrome is made with three of the major criteria, two of which must include polyradiculoneuropathy and clonal PCD, and at least one of the minor criteria. Risk Stratification Because the pathogenesis of the syndrome is not well understood, risk stratification is limited to clinical phenotype rather than specific molecular markers. Risk factors include low serum albumin, age, pleural effusion, pulmonary hypertension, and reduced eGFR. Risk‐Adapted Therapy For those patients with a dominant sclerotic plasmacytoma, first line therapy is irradiation. Patients with diffuse sclerotic lesions or disseminated bone marrow involvement and for those who have progression of their disease 3 to 6 months after completing radiation therapy should receive systemic therapy. Corticosteroids are temporizing, but alkylators are the mainstay of treatment, either in the form of low dose conventional therapy or high dose with stem cell transplantation. Lenalidomide shows promise with manageable toxicity. Thalidomide and bortezomib also have activity, but their benefit needs to be weighed against their risk of exacerbating the peripheral neuropathy. Prompt recognition and institution of both supportive care measures and therapy directed against the plasma cell result in the best outcomes.
URGENT GASTROSCOPY THROUGH PEG FISTULA APPROACH
Authors: G Vujnovic, M Vrbnjak, M Drobnic, K Pivko, B Kostanjevec
Journal: Endoscopy (2019)

Gastroscopy in the best way treat upper GI bleeding. In some medical condition natural feeding way is closed. Percutaneous endoscopic gastrostomy (PEG) fistula in such patients is usually narrow for standard gastroscope. Endoscopy of such patient can be challenging. Dieulafoy's lesion is rare cause of GI bleeding.
Use of Plasma Fragments of Propeptides of Type III, V, and VI Procollagen for the Detection of Liver Fibrosis in Type 2 Diabetes
Authors: Fernando Bril, Diana Julie Leeming, Morten Asser Karsdal, Srilaxmi Kalavalapalli, Diana Barb, Jinping Lai, Matthew Rabe, Kenneth Cusi
Journal: Diabetes Care (2019)

OBJECTIVE This study assessed the utility of plasma fragments of propeptides of type III (PRO-C3), V (PRO-C5), and VI (PRO-C6) procollagen for the detection of liver fibrosis in patients with type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS Patients with T2DM (n = 191) underwent an oral glucose tolerance test, a liver 1H-MRS, and a liver biopsy when indicated. PRO-C3, PRO-C5, and PRO-C6 were blindly assessed. RESULTS PRO-C3 performed well for the diagnosis of moderate-to-advanced (area under the receiver operating characteristic curve [AUROC] 0.81 [95% CI 0.74–0.88]) and advanced (AUROC 0.88 [0.80–0.95]) fibrosis in T2DM patients. Its performance was similar to that of AST to platelet ratio index (APRI) (AUROC 0.83 and 0.87, respectively) and Fibrosis-4 (FIB-4) (AUROCs 0.83 and 0.86, respectively) scores. Use of PRO-C5 and PRO-C6 did not improve the accuracy to detect liver fibrosis. After 18 months, PRO-C3 changes were associated with changes in fibrosis stages. CONCLUSIONS PRO-C3 performed well for the detection of fibrosis in T2DM patients and showed promising results for prediction of histological changes in fibrosis stage with treatment.
PROPOFOL SEDATION IN COLONOSCOPY: FROM SATISFIED PATIENTS TO IMPROVED QUALITY INDICATORS
Authors: F Abu Baker, O Gal, A Mari, D Feldman, B Ovadia, Y Kopelman
Journal: Endoscopy (2019)

Propofol mediated sedation (PMS) is safe and is clearly associated with increased patient satisfaction. However, whether it results in a favourable effect on colonoscopy outcomes and performance compared to standard sedation with benzodiazepines/opiates remains unclear. This current study aims to determine the effect of PMS on colonoscopy quality measures compared to traditional sedation.
Diagnosis and treatment of chronic inducible urticaria
Authors: Marcus Maurer, Tomasz Hawro, Karoline Krause, Markus Magerl, Martin Metz, Frank Siebenhaar, Dorothea Terhorst‐Molawi, Karsten Weller, Torsten Zuberbier, Sabine Altrichter
Journal: Allergy (2019)

Dr Weller reports personal fees from Dr R. Pfleger, personal fees from UCB, personal fees from Uriach, personal fees from Moxie, personal fees from Novartis, outside the submitted work. Prof. Magerl reports personal fees from Moxie and personal fees from Novartis, outside the submitted work. Prof. Maurer reports grants and personal fees from Allakos, personal fees from Aralez, personal fees from Alnylam, grants from AstraZeneca, grants and personal fees from BioCryst, grants from Blueprint, personal fees from CSL Behring, grants and personal fees from FAES, grants and personal fees from Genentech, personal fees from Kalvista, grants and personal fees from Menarini, grants from Leo Pharma, grants and personal fees from Moxie, grants and personal fees from MSD, grants from Pharming, personal fees from Pharvaris, grants and personal fees from Roche, grants and personal fees from Sanofi, grants and personal fees from Shire/Takeda, grants and personal fees from UCB, grants and personal fees from Uriach, outside the submitted work. Dr Metz reports personal fees from Moxie, personal fees from Novartis, personal fees from Sanofi, outside the submitted work. Dr Siebenhaar reports personal fees from Novartis, personal fees from Allakos, nonfinancial support from Moxie GmbH, during the conduct of the study. Dr Terhorst-Molawi has nothing to disclose. Dr Hawro has nothing to disclose. Dr Krause reports personal fees from Novartis, personal fees from Moxie, outside the submitted work. Dr Zuberbier reports personal fees from Astra Zeneca, personal fees from AbbVie, personal fees from ALK, personal fees from Almirall, personal fees from Astellas, personal fees from Bayer Health Care, personal fees from Bencard, personal fees from Berlin Chemie, personal fees from FAES, personal fees from HAL, personal fees from Leti, personal fees from MEDA, personal fees from Menarini, personal fees from Merck, personal fees from MSD, grants and personal fees from Novartis, personal fees from Pfizer, personal fees from Sanofi, personal fees from Stallergenes, personal fees from Takeda, personal fees from Teva, personal fees from UCB, grants from Henkel, personal fees from Kryolan, personal fees from L'Oreal, outside the submitted work; and Organizational Affiliations: Committee member, WHO-Initiative “Allergic Rhinitis and its Impact on Asthma” (ARIA)Ðember of the Board, German Society for Allergy and Clinical Immunology (DGAKI)Ðead, European Centre for Allergy Research Foundation (ECARF)Ðecretary General, Global Allergy and Asthma European Network (GA2LEN)Ðember, Committee on Allergy Diagnosis and Molecular Allergology, World Allergy Organization (WAO). Dr Altrichter reports personal fees from Moxie GmbH, other from Allakos, Inc, outside the submitted work.
PAPILLA CANNULATION USING HOME-MADE MONORAIL SPHINCTEROME AFTER EUS-GUIDED RENDEZVOUS TECHNIQUE
Authors: M Bozhychko, C Mangas-Sanjuan, L Compañy, FA Ruiz, J Martínez Sempere, JA Casellas, J Ramón Aparicio
Journal: Endoscopy (2019)

When endoscopic retrograde cholangiopancreatography (ERCP) fails, EUS-guided rendezvous technique (EUS-RV) is an effective alternative. However, guidewire extraction through the duodenoscope is time-consuming and has some complications.
18F-NaF Uptake in Calcified Uterine Leiomyoma
Authors: Esha Kothekar, William Y. Raynor, Thomas J. Werner, Abass Alavi, Joshua F. Baker
Journal: Clinical Nuclear Medicine (2019)

Abstract Uterine leiomyomas (fibroids) represent the most common benign pelvic tumors in women as well as the leading indication for hysterectomies in the United States. Risk factors for the development of fibroids include increasing age, hormonal changes, genetics, and race, among others. The lifetime risk of developing fibroids is greater than 80% among African American women, who also have the more severe form of this condition. We are presenting a case of incidental 18 F-NaF uptake in the calcified uterine leiomyoma of a 52-year-old African American woman.