tbuckley/cabot-search huggingface dataset:
Abstract 15689: Epigenetic Factor CBP/p300 in Pulmonary Arterial Hypertension
Authors: Alice Bourgeois, Karima Habbout, William Robert, Mark Orcholski, Sandra Breuils-Bonnet, Roxane Paulin, Steeve Provencher, Sebastien Bonnet, Olivier Boucherat
Journal: Circulation (2019)

Background: Pulmonary arterial hypertension (PAH) is characterized by elevated pulmonary artery (PA) pressure and vascular resistance, which leads to right heart failure and premature death. Excess...
Metabolic Imaging Patterns on 18F-FDG PET in Acute and Subacute LGI1 Autoimmune Limbic Encephalitis
Authors: Nikhil Seniaray, Ritu Verma, Rajeev Ranjan, Ethel Belho, Harsh Mahajan
Journal: Clinical Nuclear Medicine (2020)

Abstract Autoimmune encephalitis is a diverse group of neuropsychiatric disorders, which are difficult to diagnose clinically. The disorder presents acutely or subacutely with alteration of consciousness, cognitive decline, seizures, and abnormal movements. Autoantibodies are directed against intracellular antigens or extracellular domains of cell surface proteins, critical for neuronal excitability. 18 F-FDG PET/CT has been used to diagnose the metabolic derangement in the brain due to various antibodies. Here we describe a case where acute and subacute phase of disease was visualized on serial 18 F-FDG PET/CT.
Human rights parables for a post-pandemic world
Authors: Alicia Ely Yamin
Journal: The Lancet (2020)

Before the COVID-19 pandemic laid bare the structural inequalities across societies, there were diverging parables in human rights. One narrative identified the populist challenge to human rights and juxtaposed it with the cosmopolitan ideal of a multilateral order. An alternative narrative viewed populism as the symptom of democratic failure more than the cause and argued that the crisis of legitimacy facing the neoliberal, multilateral order was inextricably connected to a world where capitalist democracies have become "mere façade democracies", as Jürgen Habermas has asserted.
Comparison of the Proportions of Female and Male Corresponding Authors in Preprint Research Repositories Before and During the COVID-19 Pandemic
Authors: Mackenzie R. Wehner, Yao Li, Kevin T. Nead
Journal: JAMA Network Open (2020)

The absolute difference of the percentages of male and female corresponding authors are presented as the gender gap.Percentages do not always add to 100% because the gender of some corresponding authors was unknown.The time scale for medRxiv is shorter than that of bioRxiv owing to the more recent inception of medRxiv.
Re: Vasilis Stavrinides, Francesco Giganti, Bruce Trock, et al. Five-year Outcomes of Magnetic Resonance Imaging–based Active Surveillance for Prostate Cancer: A Large Cohort Study. Eur Urol 2020;78:443–51
Authors: Francesco Montorsi, Giorgio Gandaglia, Nicola Fossati, Andrea Salonia, Alberto Briganti
Journal: European Urology (2020)
Abstract PO-062: Early impact of COVID-19 in cancer care: The experience of a Brazilian outpatient clinic
Authors: Cinthya Sternberg, Bianca Vivas, Thamine Lessa Andrade, Ana Paula Vila Nova, Ana Paula Fernandes, Camila Alves, Adriana Alvez, Lise Hizumi, Simone Dias, Pablicio Nobre, Aknar Calabrich, Anelisa Coutinho, Alex Pimenta
Journal: Clinical Cancer Research (2020)

Abstract The first confirmed case of coronavirus disease 2019 (COVID-19) in Latin America was reported on February 25th, 2020, in Brazil. As COVID19 disease incidence escalated in the country, management of cancer patients required immediate action and oncology clinics were urged to establish a contingency plan. We were the first oncology clinic in Brazil to install a COVID-19 Management Committee to elaborate and implement best practices to assist cancer outpatients as well as to provide a safe environment for clinical staff and other employees at the outpatient clinics. We started monitoring our staff and employees on March 13th, a day after we installed a contingency plan for COVID-19 management and WHO declared COVID-19 a pandemic. So far, out of 1,022 staff and employees of our group, we have registered 12.3% suspected and 3.8% confirmed COVID-19 cases, and only 1 case severe enough to require hospitalization. As COVID-19 testing is not widely available, not all patients were tested and/or we did not have access to results, as tests might have been conducted somewhere other than the clinic. Out of 98 patients with suspected COVID-19 being monitored by SCIA (ranging from 29 to 90yo), 68% were tested and 43% of these were positive. As for the monitored population (n=98), 62.6% were undergoing treatment, 31.8% tested positive, and 9.9% died due to COVID-19 (31% of the confirmed cases, matching literature data). All deaths by COVID-19 (n=9) occurred in patients above 68yo, and 77% (n=6) were undergoing cancer treatment. To the best of our knowledge, this is the first report of COVID-19 incidence in cancer patients in Brazil. The challenges of cancer treatment in the midst of a global pandemic highlight the importance of a rapid response by institutions, where organizational structure, strategic planning, agility in guidelines implementation, and alternative ways to protect and support clinical staff, employees, and patients may be the keys to mitigate pandemic effects. Citation Format: Cinthya Sternberg, Bianca Vivas, Thamine Lessa Andrade, Ana Paula Vila Nova, Ana Paula Fernandes, Camila Alves, Adriana Alvez, Lise Hizumi, Simone Dias, Pablicio Nobre, Aknar Calabrich, Anelisa Coutinho, Alex Pimenta. Early impact of COVID-19 in cancer care: The experience of a Brazilian outpatient clinic [abstract]. In: Proceedings of the AACR Virtual Meeting: COVID-19 and Cancer; 2020 Jul 20-22. Philadelphia (PA): AACR; Clin Cancer Res 2020;26(18_Suppl):Abstract nr PO-062.
FLASH: Fluorescently LAbelled Sensitive Hydrogel to monitor bioscaffolds degradation during neocartilage generation
Authors: Carmine Onofrillo, Serena Duchi, Sam Francis, Cathal D. O'Connell, Lilith M. Caballero Aguilar, Stephanie Doyle, Zhilian Yue, Gordon G. Wallace, Peter F. Choong, Claudia Di Bella
Journal: Biomaterials (2020)
An invited commentary on: “One anastomosis/Mini Gastric Bypass (OAGB-MGB) as revisional bariatric surgery after failed primary adjustable gastric band (LAGB) and Sleeve Gastrectomy (SG): A systematic review of 1075 patients” (international journal of surgery 2020;81:32–38)
Authors: Mohammad Hamdy Abo-Ryia
Journal: International Journal of Surgery (2020)
Decision Aids and the Absence of Expected Longevity Benefits of Mammography Screening in Women 75 Years and Older—Reply
Authors: Mara A. Schonberg, Mary Beth Hamel, Christine E. Kistler
Journal: JAMA Internal Medicine (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Multi-omic comparison of Alzheimer’s variants in human ESC–derived microglia reveals convergence at <i>APOE</i>
Authors: Tongfei Liu, Bing Zhu, Yan Liu, Xiaoming Zhang, Jun Yin, Xiaoguang Li, LuLin Jiang, Andrew P. Hodges, Sara Brin Rosenthal, Lisa Zhou, Joel Yancey, Amanda McQuade, Mathew Blurton-Jones, Rudolph E. Tanzi, Timothy Y. Huang, Huaxi Xu
Journal: The Journal of Experimental Medicine (2020)

Variations in many genes linked to sporadic Alzheimer's disease (AD) show abundant expression in microglia, but relationships among these genes remain largely elusive. Here, we establish isogenic human ESC-derived microglia-like cell lines (hMGLs) harboring AD variants in CD33, INPP5D, SORL1, and TREM2 loci and curate a comprehensive atlas comprising ATAC-seq, ChIP-seq, RNA-seq, and proteomics datasets. AD-like expression signatures are observed in AD mutant SORL1 and TREM2 hMGLs, while integrative multi-omic analysis of combined epigenetic and expression datasets indicates up-regulation of APOE as a convergent pathogenic node. We also observe cross-regulatory relationships between SORL1 and TREM2, in which SORL1R744X hMGLs induce TREM2 expression to enhance APOE expression. AD-associated SORL1 and TREM2 mutations also impaired hMGL Aβ uptake in an APOE-dependent manner in vitro and attenuated Aβ uptake/clearance in mouse AD brain xenotransplants. Using this modeling and analysis platform for human microglia, we provide new insight into epistatic interactions in AD genes and demonstrate convergence of microglial AD genes at the APOE locus.
Laparoscopic hepatectomy is safe and effective for the management of patients with colorectal cancer liver metastases in a population-based analysis in Ontario, Canada. A retrospective cohort study
Authors: Christopher D. Griffiths, Keying Xu, Julian Wang, Tyler McKechnie, Amiram Gafni, Sameer Parpia, Leyo Ruo, Pablo E. Serrano
Journal: International Journal of Surgery (2020)
Abstract 15404: Whole Exome Sequencing of Spontaneous Coronary Artery Dissection (SCAD) Cases Discovers Enrichment of Rare Disruptive Variants in Fibrillar Collagen Genes
Authors: Seyedeh M Zekavat, Erina Kii, Mark Chaffin, Krishna Aragam, Malissa J Wood, Hongyu Zhao, Sekar Kathiresan, Mark E Lindsay, Pradeep Natarajan
Journal: Circulation (2018)

Introduction: Spontaneous coronary artery dissection (SCAD) is a non-atherosclerotic cause of acute myocardial infarction (MI) largely affecting young individuals. While most cases are sporadic, a ...
Effectiveness of pelvic floor muscle training with and without electromyographic biofeedback for urinary incontinence in women: multicentre randomised controlled trial
Authors: Suzanne Hagen, Andrew Elders, Susan Stratton, Nicole Sergenson, Carol Bugge, Sarah Dean, Jean Hay-Smith, Mary Kilonzo, Maria Dimitrova, Mohamed Abdel-Fattah, Wael Agur, Jo Booth, Cathryn Glazener, Karen Guerrero, Alison McDonald, John Norrie, Louise R Williams, Doreen McClurg
Journal: BMJ (2020)

Abstract Objective To assess the effectiveness of pelvic floor muscle training (PFMT) plus electromyographic biofeedback or PFMT alone for stress or mixed urinary incontinence in women. Design Parallel group randomised controlled trial. Setting 23 community and secondary care centres providing continence care in Scotland and England. Participants 600 women aged 18 and older, newly presenting with stress or mixed urinary incontinence between February 2014 and July 2016: 300 were randomised to PFMT plus electromyographic biofeedback and 300 to PFMT alone. Interventions Participants in both groups were offered six appointments with a continence therapist over 16 weeks. Participants in the biofeedback PFMT group received supervised PFMT and a home PFMT programme, incorporating electromyographic biofeedback during clinic appointments and at home. The PFMT group received supervised PFMT and a home PFMT programme. PFMT programmes were progressed over the appointments. Main outcome measures The primary outcome was self-reported severity of urinary incontinence (International Consultation on Incontinence Questionnaire-urinary incontinence short form (ICIQ-UI SF), range 0 to 21, higher scores indicating greater severity) at 24 months. Secondary outcomes were cure or improvement, other pelvic floor symptoms, condition specific quality of life, women’s perception of improvement, pelvic floor muscle function, uptake of other urinary incontinence treatment, PFMT self-efficacy, adherence, intervention costs, and quality adjusted life years. Results Mean ICIQ-UI SF scores at 24 months were 8.2 (SD 5.1, n=225) in the biofeedback PFMT group and 8.5 (SD 4.9, n=235) in the PFMT group (mean difference −0.09, 95% confidence interval −0.92 to 0.75, P=0.84). Biofeedback PFMT had similar costs (mean difference £121 ($154; €133), −£409 to £651, P=0.64) and quality adjusted life years (−0.04, −0.12 to 0.04, P=0.28) to PFMT. 48 participants reported an adverse event: for 23 this was related or possibly related to the interventions. Conclusions At 24 months no evidence was found of any important difference in severity of urinary incontinence between PFMT plus electromyographic biofeedback and PFMT alone groups. Routine use of electromyographic biofeedback with PFMT should not be recommended. Other ways of maximising the effects of PFMT should be investigated. Trial registration ISRCTN57756448 .
A cuckoo COVID coincidence?
Authors: James D. Chalmers, Mike Lonergan
Journal: European Respiratory Journal (2020)

We are grateful to A.H. Morice for his reminder of the limits of observational data, and the need for caution in its interpretation. And we accept that it is unlikely to ever be proved conclusively that the dramatic restrictions imposed as countries locked down caused the dramatic changes in epidemic trajectories, even though the epidemiological changes seemed to follow the behavioural changes. However, there is also a large logical leap from observing the Swedish data to inferring that social distancing "measures can only have had a minor effect". There are limitations to inferring causality from observational data, but lockdowns have almost certainly saved lives worldwide <https://bit.ly/2YWAhhl>
AuthentiCT: a model of ancient DNA damage to estimate the proportion of present-day DNA contamination
Authors: Stéphane Peyrégne, Benjamin M. Peter
Journal: Genome biology (2020)

Abstract Contamination from present-day DNA is a fundamental issue when studying ancient DNA from historical or archaeological material, and quantifying the amount of contamination is essential for downstream analyses. We present AuthentiCT, a command-line tool to estimate the proportion of present-day DNA contamination in ancient DNA datasets generated from single-stranded DNA libraries. The prediction is based solely on the patterns of post-mortem damage observed on ancient DNA sequences. The method has the power to quantify contamination from as few as 10,000 mapped sequences, making it particularly useful for analysing specimens that are poorly preserved or for which little data is available.
A Manual of Practical Anatomy.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effectiveness of <i>Curcuma longa</i> Extract for the Treatment of Symptoms and Effusion–Synovitis of Knee Osteoarthritis
Authors: Zhiqiang Wang, Graeme Jones, Tania Winzenberg, Guoqi Cai, Laura L. Laslett, Dawn Aitken, Ingrid Hopper, Ambrish Singh, Robert Jones, Jurgen Fripp, Changhai Ding, Benny Antony
Journal: Annals of Internal Medicine (2020)

Background: Current pharmacologic therapies for patients with osteoarthritis are suboptimal. Objective: To determine the efficacy of Curcuma longa extract (CL) for reducing knee symptoms and effusion–synovitis in patients with symptomatic knee osteoarthritis and knee effusion–synovitis. Design: Randomized, double-blind, placebo-controlled trial. (Australian New Zealand Clinical Trials Registry: ACTRN12618000080224) Setting: Single-center study with patients from southern Tasmania, Australia. Participants: 70 participants with symptomatic knee osteoarthritis and ultrasonography-defined effusion–synovitis. Intervention: 2 capsules of CL (n = 36) or matched placebo (n = 34) per day for 12 weeks. Measurements: The 2 primary outcomes were changes in knee pain on a visual analogue scale (VAS) and effusion–synovitis volume on magnetic resonance imaging (MRI). The key secondary outcomes were change in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and cartilage composition values. Outcomes were assessed over 12 weeks. Results: CL improved VAS pain compared with placebo by −9.1 mm (95% CI, −17.8 to −0.4 mm [P = 0.039]) but did not change effusion–synovitis volume (3.2 mL [CI, −0.3 to 6.8 mL]). CL also improved WOMAC knee pain (−47.2 mm [CI, −81.2 to −13.2 mm]; P = 0.006) but not lateral femoral cartilage T2 relaxation time (−0.4 ms [CI, −1.1 to 0.3 ms]). The incidence of adverse events was similar in the CL (n = 14 [39%]) and placebo (n = 18 [53%]) groups (P = 0.16); 2 events in the CL group and 5 in the placebo group may have been treatment related. Limitation: Modest sample size and short duration. Conclusion: CL was more effective than placebo for knee pain but did not affect knee effusion–synovitis or cartilage composition. Multicenter trials with larger sample sizes are needed to assess the clinical significance of these findings. Primary Funding Source: University of Tasmania and Natural Remedies Private Limited.
Metabolic Architecture of Acute Exercise Response in Middle-Aged Adults in the Community
Authors: Matthew Nayor, Ravi V. Shah, Patricia E. Miller, Jasmine B. Blodgett, Melissa Tanguay, Alexander R. Pico, Venkatesh L. Murthy, Rajeev Malhotra, Nicholas E. Houstis, Amy Deik, Kerry A. Pierce, Kevin Bullock, Lucas Dailey, Raghava S. Velagaleti, Stephanie A. Moore, Jennifer E. Ho, Aaron L. Baggish, Clary B. Clish, Martin G. Larson, Ramachandran S. Vasan, Gregory D. Lewis
Journal: Circulation (2020)

Background: Whereas regular exercise is associated with lower risk of cardiovascular disease and mortality, mechanisms of exercise-mediated health benefits remain less clear. We used metabolite profiling before and after acute exercise to delineate the metabolic architecture of exercise response patterns in humans. Methods: Cardiopulmonary exercise testing and metabolite profiling was performed on Framingham Heart Study participants (age 53±8 years, 63% women) with blood drawn at rest (n=471) and at peak exercise (n=411). Results: We observed changes in circulating levels for 502 of 588 measured metabolites from rest to peak exercise (exercise duration 11.9±2.1 minutes) at a 5% false discovery rate. Changes included reductions in metabolites implicated in insulin resistance (glutamate, −29%; P =1.5×10 −55 ; dimethylguanidino valeric acid [DMGV], −18%; P =5.8×10 −18 ) and increases in metabolites associated with lipolysis (1-methylnicotinamide, +33%; P =6.1×10 −67 ), nitric oxide bioavailability (arginine/ornithine + citrulline, +29%; P =2.8×10 −169 ), and adipose browning (12,13-dihydroxy-9Z-octadecenoic acid +26%; P =7.4×10 −38 ), among other pathways relevant to cardiometabolic risk. We assayed 177 metabolites in a separate Framingham Heart Study replication sample (n=783, age 54±8 years, 51% women) and observed concordant changes in 164 metabolites (92.6%) at 5% false discovery rate. Exercise-induced metabolite changes were variably related to the amount of exercise performed (peak workload), sex, and body mass index. There was attenuation of favorable excursions in some metabolites in individuals with higher body mass index and greater excursions in select cardioprotective metabolites in women despite less exercise performed. Distinct preexercise metabolite levels were associated with different physiologic dimensions of fitness (eg, ventilatory efficiency, exercise blood pressure, peak V o 2 ). We identified 4 metabolite signatures of exercise response patterns that were then analyzed in a separate cohort (Framingham Offspring Study; n=2045, age 55±10 years, 51% women), 2 of which were associated with overall mortality over median follow-up of 23.1 years ( P ≤0.003 for both). Conclusions: In a large sample of community-dwelling individuals, acute exercise elicits widespread changes in the circulating metabolome. Metabolic changes identify pathways central to cardiometabolic health, cardiovascular disease, and long-term outcome. These findings provide a detailed map of the metabolic response to acute exercise in humans and identify potential mechanisms responsible for the beneficial cardiometabolic effects of exercise for future study.
Two-Year, Randomized, Controlled Trial of Belimumab in Lupus Nephritis
Authors: Richard Furie, Brad H. Rovin, Frédéric Houssiau, Ana Malvar, Y.K. Onno Teng, Gabriel Contreras, Zahir Amoura, Xueqing Yu, Chi-Chiu Mok, Mittermayer B. Santiago, Amit Saxena, Yulia Green, Beulah Ji, Christi Kleoudis, Susan W. Burriss, Carly Barnett, David A. Roth
Journal: New England Journal of Medicine (2020)

In adults with active lupus nephritis, the efficacy and safety of intravenous belimumab as compared with placebo, when added to standard therapy (mycophenolate mofetil or cyclophosphamide–azathioprine), are unknown.
Liquid biopsy technologies for hematological diseases
Authors: Yatian Fu, Yiyuan Zhang, Bee Luan Khoo
Journal: Medicinal Research Reviews (2020)

Abstract Since the discovery of circulating tumor cells in 1869, technological advances in studying circulating biomarkers from patients' blood have made the diagnosis of nonhematologic cancers less invasive. Technological advances in the detection and analysis of biomarkers provide new opportunities for the characterization of other disease types. When compared with traditional biopsies, liquid biopsy markers, such as exfoliated bladder cancer cells, circulating cell‐free DNA (cfDNA), and extracellular vesicles (EV), are considered more convenient than conventional biopsies. Liquid biopsy markers undoubtedly have the potential to influence disease management and treatment dynamics. Our main focuses of this review will be the cell‐based, gene‐based, and protein‐based key liquid biopsy markers (including EV and cfDNA) in disease detection, and discuss the research progress of these biomarkers used in conjunction with liquid biopsy. First, we highlighted the key technologies that have been broadly adopted used in hematological diseases. Second, we introduced the latest technological developments for the specific detection of cardiovascular disease, leukemia, and coronavirus disease. Finally, we concluded with perspectives on these research areas, focusing on the role of microfluidic technology and artificial intelligence in point‐of‐care medical applications. We believe that the noninvasive capabilities of these technologies have great potential in the development of diagnostics and can influence treatment options, thereby advancing precision disease management.