tbuckley/cabot-search huggingface dataset:
Patient-Reported Functional Outcomes After Hypofractionated or Conventionally Fractionated Radiation for Prostate Cancer: A National Cohort Study in England
Authors: Julie Nossiter, Arunan Sujenthiran, Thomas E. Cowling, Matthew G. Parry, Susan C. Charman, Paul Cathcart, Noel W. Clarke, Heather Payne, Jan van der Meulen, Ajay Aggarwal
Journal: Journal of Clinical Oncology (2020)

PURPOSE The aim of the current study was to determine patient-reported functional outcomes in men with prostate cancer (PCa) undergoing moderately hypofractionated (H-RT) or conventionally fractionated radiation therapy (C-RT) in a national cohort study. PATIENDS AND METHODS All men diagnosed with PCa between April 2014 and September 2016 in the English National Health Service undergoing C-RT or H-RT were identified in the National Prostate Cancer Audit and mailed a questionnaire at least 18 months after diagnosis. We estimated differences in patient-reported urinary, bowel, sexual, and hormonal function—Expanded Prostate Cancer Index Composite short-form 26 domain scores on a 0 to 100 scale—and health-related quality of life—EQ-5D-5L on a 0 to 1 scale—using linear regression with adjustment for patient, tumor, and treatment-related factors in addition to GI and genitourinary baseline function, with higher scores representing better outcomes. RESULTS Of the 17,058 men in the cohort, 77% responded: 8,432 men received C-RT (64.2%) and 4,699 H-RT (35.8%). Men in the H-RT group were older (age ≥ 70 years: 67.5% v 60.9%), fewer men had locally advanced disease (56.5% v 71.3%), were less likely to receive androgen-deprivation therapy (79.5% v 87.8%), and slightly more men had pretreatment genitourinary procedures (24.2% v 21.2%). H-RT was associated with small increases in adjusted mean Expanded Prostate Cancer Index Composite short-form 26 sexual (3.3 points; 95% CI, 2.1 to 4.5; P &lt; .001) and hormonal function scores (3.2 points; 95% CI, 1.8 to 4.6; P &lt; .001). These differences failed to meet established thresholds for a clinically meaningful change. There were no statistically significant differences in urinary or bowel function and quality of life. CONCLUSION This is the first national cohort study comparing functional outcomes after H-RT and C-RT reported by patients. These real-world results further support the use of H-RT as the standard for radiation therapy in men with nonmetastatic PCa.
Electroencephalographic Biomarkers for Predicting Antidepressant Response
Authors: Adrienne Grzenda, Alik S. Widge
Journal: JAMA Psychiatry (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Clinical Significance and Outcomes in Trial of Nabiximols for Treatment of Cannabis Dependence
Authors: Robert A. Kleinman, Michael J. Ostacher
Journal: JAMA Internal Medicine (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Superhydrophobic drug-loaded mesoporous silica nanoparticles capped with β-cyclodextrin for ultrasound image-guided combined antivascular and chemo-sonodynamic therapy
Authors: Yi-Ju Ho, Cheng-Han Wu, Qiao-feng Jin, Chih-Yu Lin, Pei-Hua Chiang, Nan Wu, Ching-Hsiang Fan, Chia-Min Yang, Chih-Kuang Yeh
Journal: Biomaterials (2019)
PIG-a Mutations in a Brazilian Cohort of Patients with Paroxysmal Nocturnal Hemoglobinuria
Authors: Patricia Eiko Yamakawa, Ana Rita Da Fonseca, Caio Perez Gomes, Agatha Mendes, Fabiana Bettoni, Vinicius Campos de Molla, Martha Mariana Arruda, Maria Stella Figueiredo, Joao Bosco Pesquero, Celso Arrais-Rodrigues
Journal: Blood (2019)
Multiyear Follow-up of AAV5-hFVIII-SQ Gene Therapy for Hemophilia A
Authors: K. John Pasi, Savita Rangarajan, Nina Mitchell, Will Lester, Emily Symington, Bella Madan, Michael Laffan, Chris B. Russell, Mingjin Li, Glenn F. Pierce, Wing Y. Wong
Journal: New England Journal of Medicine (2020)

Adeno-associated virus (AAV)-mediated gene therapy is under investigation as a therapeutic option for persons with hemophilia A. Efficacy and safety data include 3 years of follow-up after a single administration of AAV5-hFVIII-SQ.We report durable efficacy, long-term safety, and clinical and biologic results in 15 adults with severe hemophilia A (factor VIII level, ≤1 IU per deciliter) who had received a single infusion of AAV5-hFVIII-SQ at various dose levels. We evaluated the factor VIII level, annualized rate of bleeding events, use of factor VIII, safety, expression kinetics, and biologic markers of AAV transduction for up to 3 years.Three years after infusion, two participants (one who had received 6×1012 vector genomes [vg] per kilogram of body weight and one who had received 2×1013 vg per kilogram) had factor VIII expression of less than 1 IU per deciliter, as assessed on chromogenic assay. Seven participants (who had received 6×1013 vg per kilogram) had a median factor VIII expression of 20 IU per deciliter; the median number of annualized treated bleeding events was 0, and the median use of exogenous factor VIII was reduced from 138.5 infusions to 0 infusions per year. Bleeding in all target joints (major joints with ≥3 bleeding events within 6 months) in this cohort resolved (≤2 bleeding events within 12 months). Two years after infusion, six participants (who had received 4×1013 vg per kilogram) had a median factor VIII expression of 13 IU per deciliter; the median annualized rate of bleeding events was 0, and the median use of factor VIII was reduced from 155.5 infusions to 0.5 infusions per year. Bleeding in target joints resolved in five of six participants. The factor VIII pharmacodynamic profiles reflected cellular turnover in the blood and molecular events leading to episomal DNA stabilization for persistent expression, findings that are consistent with previous observations in two model systems. Transgene-derived human factor VIII (hFVIII) protein activity mirrored native hFVIII in hemostatic ability. No inhibitor development, thromboses, deaths, or persistent changes in liver-function tests were observed.Gene therapy with AAV5-hFVIII-SQ vector in participants with hemophilia A resulted in sustained, clinically relevant benefit, as measured by a substantial reduction in annualized rates of bleeding events and complete cessation of prophylactic factor VIII use in all participants who had received 4×1013 vg per kilogram or 6×1013 vg per kilogram of the gene therapy. (Funded by BioMarin Pharmaceutical; ClinicalTrials.gov number, NCT02576795; EudraCT number, 2014-003880-38.).
Abstract 17100: Development Of Hypertension And Modulation Of Sodium Excretion In Response To Angiotensin Ii Are Dependent On Chloride Intake
Authors: Jessica Liberona, Patricio A Araos, Rodrigo R Alzamora, Andres Stutzin, Luis Michea
Journal: Circulation (2019)

Introduction: Metabolic studies showed that, in addition to sodium, the intake of chloride is necessary for the development of hypertension due to high salt diet or mineralocorticoids Hypothesis: C...
FDA bans most flavoured e-cigarettes as lung injury epidemic slows
Authors: Janice Hopkins Tanne
Journal: BMJ (2020)

The US Food and Drug Administration will ban most flavoured electronic cigarettes from 1 February.1 The latest figures show that since the outbreak of the epidemic in summer 2019 more than 2500 people in the US have been admitted to hospital with lung problems related to e-cigarette use, of whom 55 have died.2

The FDA said that it would ban fruit, candy, and mint flavoured pods that contain vaping liquids but not pods flavoured with tobacco or menthol. Flavoured pods are popular with young people. The sale of vaping fluids from open tank systems in vaping shops will be allowed to continue.

President Donald Trump had earlier called for a ban on all flavoured vaping supplies. He …
Abstract 3130: Skeletal Myoblast Sheet Transplantation Suppressed Endocardial Fibrosis And Improved Diastolic Function In Pressure-induced Right Heart Failure: A Strategy Of Myocardial Regeneration In Congenital Heart Disease
Authors: Takaya Hoashi, Goro Matsumiya, Hajime Ichikawa, Takayoshi Ueno, Shigeru Miyagawa, Naomasa Kawaguchi, Nariaki Matsuura, Tatsuya Shimizu, Teruo Okano, Yoshiki Sawa
Journal: Circulation (2007)

Background: Development of right ventricular dysfunction by pressure overload is often seen even after definitive repair for congenital heart defects. After a compensated hypertrophy period, prolon...
Exploitation of the Cooperative Behaviors of Anti-CRISPR Phages
Authors: Anne Chevallereau, Sean Meaden, Olivier Fradet, Mariann Landsberger, Alice Maestri, Ambarish Biswas, Sylvain Gandon, Stineke van Houte, Edze R. Westra
Journal: Cell Host & Microbe (2019)

Bacteriophages encoding anti-CRISPR proteins (Acrs) must cooperate to overcome phage resistance mediated by the bacterial immune system CRISPR-Cas, where the first phage blocks CRISPR-Cas immunity in order to allow a second Acr phage to successfully replicate. However, in nature, bacteria are frequently not pre-immunized, and phage populations are often not clonal, exhibiting variations in Acr presence and strength. We explored how interactions between Acr phages and initially sensitive bacteria evolve, both in the presence and absence of competing phages lacking Acrs. We find that Acr phages benefit "Acr-negative" phages by limiting the evolution of CRISPR-based resistance and helping Acr-negative phages to replicate on resistant host sub-populations. These benefits depend on the strength of CRISPR-Cas inhibitors and result in strong Acrs providing smaller fitness advantages than weaker ones when Acr phages compete with Acr-negative phages. These results indicate that different Acr types shape the evolutionary dynamics and social interactions of phage populations in natural communities.
Targeting the Activating Mutations of NOTCH1 in T-Cell Lymphoblastic Leukemia with a New SERCA Inhibitor CAD204520
Authors: Matteo Marchesini, Andrea Gherli, Anna Montanaro, Samuel Kitara, Claudia Sorrentino, Luca Pagliaro, Anne-Marie Lund Winter, Chiara Rompietti, Donatella Stilli, Federica Rizzi, Kimberly Stegmaier, Paolo Sportoletti, William Dalby-Brown, Giovanni Roti
Journal: Blood (2019)
Diverting Opioid Diversion: Does It Justify Randomly Screening Palliative Care Patients?
Authors: Leah R. Eisenberg
Journal: The American Journal of Bioethics (2020)

"Diverting Opioid Diversion: Does It Justify Randomly Screening Palliative Care Patients?." The American Journal of Bioethics, 20(1), pp. 71–72
The epidemiology of hepatitis delta virus infection in Cameroon
Authors: Camille Besombes, Richard Njouom, Juliette Paireau, Guillaume Lachenal, Gaëtan Texier, Mathurin Tejiokem, Simon Cauchemez, Jacques Pépin, Arnaud Fontanet
Journal: Gut (2020)

To investigate the distribution and risk factors of hepatitis delta virus (HDV) infection in Cameroon.We tested for hepatitis B virus (HBV) surface antigen (HBsAg) and anti-HDV antibody 14 150 samples collected during a survey whose participants were representative of the Cameroonian adult population. The samples had already been tested for hepatitis C virus and HIV antibodies.Overall, 1621/14 150 (weighted prevalence=11.9%) participants were HBsAg positive, among whom 224/1621 (10.6%) were anti-HDV positive. In 2011, the estimated numbers of HBsAg positive and HDV seropositives were 1 160 799 and 122 910 in the 15-49 years age group, respectively. There were substantial regional variations in prevalence of chronic HBV infection, but even more so for HDV (from 1% to 54%). In multivariable analysis, HDV seropositivity was independently associated with living with an HDV-seropositive person (OR=8.80; 95% CI: 3.23 to 24.0), being HIV infected (OR=2.82; 95% CI: 1.32 to 6.02) and living in the South (latitude <4°N) while having rural/outdoor work (OR=15.2; 95% CI: 8.35 to 27.6, when compared with living on latitude ≥4°N and not having rural/outdoor work).We found evidence for effective intra-household transmission of HDV in Cameroon. We also identified large differences in prevalence between regions, with cases concentrated in forested areas close to the Equator, as described in other tropical areas. The reasons underlying these geographical variations in HDV prevalence deserve further investigation.
Reactive oxygen species-responsive dexamethasone-loaded nanoparticles for targeted treatment of rheumatoid arthritis via suppressing the iRhom2/TNF-α/BAFF signaling pathway
Authors: Rongrong Ni, Guojing Song, Xiaohong Fu, Ruifeng Song, Lanlan Li, Wendan Pu, Jining Gao, Jun Hu, Qin Liu, Fengtian He, Dinglin Zhang, Gang Huang
Journal: Biomaterials (2019)
The impact of disability in survivors of critical illness (vol 43, pg 992, 2017)
Authors: Carol L Hodgson, Andrew A Udy, Michael Bailey, Jonathan Barrett, Rinaldo Bellomo, Tracey Bucknall, Belinda J Gabbe, Alisa M Higgins, Theodore J Iwashyna, Julian Hunt-Smith, Lynne J Murray, Paul S Myles, Jennie Ponsford, David Pilcher, Craig Walker, Meredith Young, DJ Cooper
Journal: Intensive Care Medicine (2017)
Feature selection and dimension reduction for single-cell RNA-Seq based on a multinomial model
Authors: F. William Townes, Stephanie C. Hicks, Martin J. Aryee, Rafael A. Irizarry
Journal: Genome biology (2019)

Single-cell RNA-Seq (scRNA-Seq) profiles gene expression of individual cells. Recent scRNA-Seq datasets have incorporated unique molecular identifiers (UMIs). Using negative controls, we show UMI counts follow multinomial sampling with no zero inflation. Current normalization procedures such as log of counts per million and feature selection by highly variable genes produce false variability in dimension reduction. We propose simple multinomial methods, including generalized principal component analysis (GLM-PCA) for non-normal distributions, and feature selection using deviance. These methods outperform the current practice in a downstream clustering assessment using ground truth datasets.
A TRAIL-Delivered Lipoprotein-Bioinspired Nanovector Engineering Stem Cell-Based Platform for Inhibition of Lung Metastasis of Melanoma
Authors: Kerong Chen, Xiaoqing Cao, Min Li, Yujie Su, Huipeng Li, Mengying Xie, Ziqi Zhang, Hongbin Gao, Xiangting Xu, Yi Han, Jianping Zhou, Wei Wang
Journal: Theranostics (2019)

Genetically engineered mesenchymal stem cells (MSCs), as non-viral gene delivery platforms, are rapidly evolving in tumor therapy due to their low immunogenicity and natural tumor-homing capacity. Methods: In this paper, we selected reconstituted high-density lipoprotein (rHDL), a lipoprotein-bioinspired nanovector with specific binding ability to scavenger receptor B type I (SR-BI) expressed on MSCs, as a transfection agent to genetically modify MSCs. pDNA encoding tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) was used as a functional gene to be transfected into the nucleus of MSCs for TRAIL expression. Lauric acid-coupled polyethyleneimine (PEI-LA) as an amphiphilic cationic polymer was synthesized to electrostatically bind to pDNA, and then incorporated into rHDL to form rHDL/PEI-LA/pDNA nanoparticles. Results: The nanoparticles exhibited homogenous particle size and excellent serum stability in vitro. Meanwhile, this SR-BI-targeted rHDL performed efficient intracellular gene delivery, specific lysosome-independent mechanism of cellular uptake and high transfection of pDNA towards MSCs. Moreover, high TRAIL expression in MSCs was detected after rHDL-mediated transfection. In vitro and in vivo results indicated that genetically engineered MSCs could accurately target to B16F10 cells, thereby producing significant apoptosis-inducing effect on aggressive melanoma. Conclusion: TRAIL-expressing MSCs engineered by rHDL nanovector was an efficient and hypotoxic method for stem cells-based pulmonary melanoma metastasis-targeting therapy.
Understanding Heterogeneity of Fetal Hemoglobin Induction through Comparative Analysis of Stage-Matched F- and a-Cells
Authors: Eugene Khandros, Peng Huang, Scott A. Peslak, Belinda Giardine, Zhe Zhang, Cheryl A Keller, Ross C. Hardison, Gerd A. Blobel
Journal: Blood (2019)
Effect of insulin-like growth factor 2 gene expression on pleuropulmonary blastoma and embryonal rhabdomyosarcoma.
Authors: Rajkumar Venkatramani, Timothy J. Triche, Wang Larry, Daniel Wai, Hiroyuki Shimada, Betty Schaub, Leo Mascarenhas
Journal: Journal of Clinical Oncology (2012)

9564 Background: The sarcomatous element in pleuropulmonary blastoma (PPB) often cannot be differentiated from embryonal rhabdomyosarcoma (ERMS) by histology, particularly when characteristic elements like cartilage and respiratory mucosa are inapparent. The initial diagnosis is often ERMS. A diagnosis of PPB is based on a combination of clinical (age, location) and pathologic features. We hypothesized that the sarcomatous portions of PPB are a form of ERMS indistinguishable from typical ERMS. We reasoned that a detailed comparison of RNA expression could clarify this hypothesis. Methods: Samples from 7 PPB patients were obtained from the rhabdomyosarcomatous portion of the tumor by macro-dissection after pathologic review of all material. Representative ERMS tumor tissue was selected from 21 ERMS cases. FFPE tissue scrolls from each case were analyzed using Affymetrix Human Exon arrays after RNA extraction with Agincourt Formapure extraction kit and amplification using the NuGEN Ovation FFPE WTA kit and labeling with the Encore Biotin Module. Data analysis utilized Partek and Genetrix software. Results: All PPB cases and 7 of 21 ERMS cases were &lt; 4 years old. 20 transcripts (10 annotated, 10 non-coding RNAs) were significantly differentially expressed in ERMS when compared to PPB patients. Insulin-like growth factor 2 (IGF2) was uniformly overexpressed in ERMS (19/21 &gt; 200) but was expressed at low levels in PPB (p&lt;0.001). 2 ERMS cases which had low level IGF2 expression were &lt; 4 years of age. Expression in the other 5 ERMS aged &lt;4 years was similar to ERMS overall (range, 500-2,000). No other differences between the two approached this degree of significance, despite a common rhabdomyogenic phenotype in the sarcomatous areas of PPB. Conclusions: We conclude that PPB is a distinct entity from most ERMS, and is not driven by IGF2 signaling. Rare cases of ERMS in the very young are more similar to PPB than common ERMS. This observation is highly significant, as IGF2 is known to drive growth in ERMS, generally related to demethylation secondary to LOH of 11p.
Whose pain is it anyway?
Authors: Benjamin Waller
Journal: British Journal of Sports Medicine (2020)

My 9-year-old daughter woke up the morning after a long day of gymnastics training and complained that her muscle hurts. ‘I need a pill to stop the pain, NOW daddy’. Right, how do I deal with this one? Should I break out the pain education metaphors? Or give her a massage? Go for some contrast baths? I decided that the appropriate referral was a joint trip to the bakery.

Over Finnish Pulla (cardamom sweet bread), we discussed that she had delayed-onset muscle soreness (DOMS), which is transient and not dangerous. During our cake-fuelled discussion, my daughter told me she had linked the use of ibuprofen for reducing a fever with helping her through the discomfort of well-earned DOMS. Rather than ‘endure’ the discomfort, she wanted a quick solution. If my 9-year-old daughter can make that connection, it is not difficult for others. Unfortunately, there is still excessive prophylactic use of prescribed …
Elastic and surgeon friendly electrospun tubes delivering PDGF-BB positively impact tendon rupture healing in a rabbit Achilles tendon model
Authors: Olivera Evrova, Gabriella Meier Bürgisser, Christian Ebnöther, Ashal Adathala, Maurizio Calcagni, Elias Bachmann, Jess G. Snedeker, Chiara Scalera, Pietro Giovanoli, Viola Vogel, Johanna Buschmann
Journal: Biomaterials (2019)