tbuckley/cabot-search huggingface dataset:
Updated perspectives on vascular cell specification and pluripotent stem cell-derived vascular organoids for studying vasculopathies
Authors: Chenxin Liu, Kaiyuan Niu, Qingzhong Xiao
Journal: Cardiovascular Research (2020)

Vasculopathy is a pathological process occurring in the blood vessel wall, which could affect the haemostasis and physiological functions of all the vital tissues/organs and is one of the main underlying causes for a variety of human diseases including cardiovascular diseases. Current pharmacological interventions aiming to either delay or stop progression of vasculopathies are suboptimal, thus searching novel, targeted, risk-reducing therapeutic agents, or vascular grafts with full regenerative potential for patients with vascular abnormalities are urgently needed. Since first reported, pluripotent stem cells (PSCs), particularly human-induced PSCs, have open new avenue in all research disciplines including cardiovascular regenerative medicine and disease remodelling. Assisting with recent technological breakthroughs in tissue engineering, in vitro construction of tissue organoid made a tremendous stride in the past decade. In this review, we provide an update of the main signal pathways involved in vascular cell differentiation from human PSCs and an extensive overview of PSC-derived tissue organoids, highlighting the most recent discoveries in the field of blood vessel organoids as well as vascularization of other complex tissue organoids, with the aim of discussing the key cellular and molecular players in generating vascular organoids.
Abstract 346: Cardiac Expression of Fetal and Adult SCN5A Isoforms in Sudden Unexplained Infant Death (SUID)
Authors: Alexandra F Williams, Kelsey Tomasek, Kyle Gregory, Carlos Fulmer, Cole Bozeman, Audra F Bryan, Feng Li, Prince J Kannankeril, Yan Ru Su
Journal: Circulation Research (2020)

Sodium Voltage-Gated Channel Alpha Subunit 5 (SNC5A) plays a vital role in cardiac depolarization and has been implicated in Long QT Syndrome and sudden cardiac death. SCN5A encodes fetal and adult isoforms, differing by splicing of exon 6A or 6B, respectively. Fetal SCN5A decreases peak sodium current, leading to slower channel activation and inactivation and providing a potential substrate for arrhythmia. Little is known about developmental expression of these isoforms. We investigated developmental expression of SCN5A isoforms in infants, toddlers, and adults, including expression ratios in SUID cases and controls (0-12 months). We extracted RNA from heart tissue collected at autopsy (fetus-24 months) with 80 SUID cases and 27 controls, and 5 adult donor hearts. RNA Integrity Numbers ranged from 4.8-9.5. Relative SCN5A isoform expression was quantified by qRT-PCR. Non-parametric t-test and ANOVA were used; P&lt;0.05 was considered statistically significant. Our results show a significant stepwise increase in adult/fetal isoform expression with age. Relative expression of adult/fetal SCN5A increased significantly from fetal-4 months to 5-24 months (P&lt;0.0001), and again in adulthood (P&lt;0.0001). There was no significant difference between case and control groups at 0-4 or 0-12 months. Expression of adult/fetal SCN5A increases significantly from birth to 24 months of age and into adulthood. Relative adult/fetal SCN5A expression is lowest during the neonatal period through 4 months, corresponding with the peak incidence of SUID. Further investigation of protein expression of SCN5A isoforms may shed light onto the age-dependent incidence of sudden death.
The Effect of Standard Versus Longer Intestinal Bypass on GLP-1 Regulation and Glucose Metabolism in Patients With Type 2 Diabetes Undergoing Roux-en-Y Gastric Bypass: The Long-Limb Study
Authors: Alexander Dimitri Miras, Anna Kamocka, Belén Pérez-Pevida, Sanjay Purkayastha, Krishna Moorthy, Ameet Patel, Harvinder Chahal, Gary Frost, Paul Bassett, Lidia Castagnetto-Gissey, Lucy Coppin, Nicola Jackson, Anne Margot Umpleby, Stephen Robert Bloom, Tricia Tan, Ahmed Rashid Ahmed, Francesco Rubino
Journal: Diabetes Care (2020)

OBJECTIVE Roux-en-Y gastric bypass (RYGB) characteristically enhances postprandial levels of glucagon-like peptide 1 (GLP-1), a mechanism that contributes to its profound glucose-lowering effects. This enhancement is thought to be triggered by bypass of food to the distal small intestine with higher densities of neuroendocrine L-cells. We hypothesized that if this is the predominant mechanism behind the enhanced secretion of GLP-1, a longer intestinal bypass would potentiate the postprandial peak in GLP-1, translating into higher insulin secretion and, thus, additional improvements in glucose tolerance. To investigate this, we conducted a mechanistic study comparing two variants of RYGB that differ in the length of intestinal bypass. RESEARCH DESIGN AND METHODS A total of 53 patients with type 2 diabetes (T2D) and obesity were randomized to either standard limb RYGB (50-cm biliopancreatic limb) or long limb RYGB (150-cm biliopancreatic limb). They underwent measurements of GLP-1 and insulin secretion following a mixed meal and insulin sensitivity using euglycemic hyperinsulinemic clamps at baseline and 2 weeks and at 20% weight loss after surgery. RESULTS Both groups exhibited enhancement in postprandial GLP-1 secretion and improvements in glycemia compared with baseline. There were no significant differences in postprandial peak concentrations of GLP-1, time to peak, insulin secretion, and insulin sensitivity. CONCLUSIONS The findings of this study demonstrate that lengthening of the intestinal bypass in RYGB does not affect GLP-1 secretion. Thus, the characteristic enhancement of GLP-1 response after RYGB might not depend on delivery of nutrients to more distal intestinal segments.
Inhibition of Complement C1s with Sutimlimab in Patients with Cold Agglutinin Disease (CAD): Interim Results of the Phase 3 Cardinal Study Long-Term Follow-up
Authors: Alexander Röth, Wilma Barcellini, Shirley D'Sa, Yoshitaka Miyakawa, Catherine M Broome, Marc Michel, David J. Kuter, Bernd Jilma, Tor Henrik Anderson Tvedt, Ilene C. Weitz, Parija Patel, Xiaoyu Jiang, Caroline Reuter, Jun Su, Frank Shafer, Michelle Lee, William Hobbs, Sigbjørn Berentsen
Journal: Blood (2020)
Impact of Hemophilia a Inhibitor on Joint Health and Health-Related Quality of Life from the Hemophilia Utilization Group Studies Part VIII in the U.S
Authors: Megan M. Ullman, Marilyn J Manco-Johnson, Jonathan C. Roberts, Nicole Crook, Rahul Khairnar, Joanne Wu, Steven Carrasco, Randall Curtis, Judith Baker, Duc Quang Tran, Michael B. Nichol
Journal: Blood (2020)
Assessment of Sales and Marketing of Online Vouchers for Discounted Direct-to-Consumer Medical Imaging Services
Authors: Sheena Desai, Priya Manjaly, Karen Lee, Sara J. Li, Cyriac Manjaly, Megan Noe, Arash Mostaghimi
Journal: JAMA Internal Medicine (2020)

This qualitative study of online vouchers for discounted DTC imaging services reveals consumerization of medicine and calls for regulations to balance convenience and cost with patient safety and physician oversight.
Single-Cell Transcriptional Landscapes of Human Bone Marrow Reveal Distinct Erythroid Phenotypes Underpinned By Genotype in Diamond-Blackfan Anemia
Authors: Deena Iskander, Guanlin Wang, Elisabeth F Heuston, Chrysi Christodoulidou, Bethan Psaila, Mark E Robinson, Aristeidis Chaidos, Pritesh Trivedi, Nikolaos Trasanidis, Alexia Katsarou, Richard Szydlo, NISC Comparative SequencingProgram, Qais Al-Oqaily, Valentina S Caputo, Kanagaraju Ponnusamy, Anindita Roy, Leena Karnik, Kikkeri Naresh, Adam J. Mead, Supat Thongjuea, Marjorie Brand, Josu de la Fuente, David M. Bodine, Irene Roberts, Anastasios Karadimitris
Journal: Blood (2020)
Internal Jugular Vein and Cerebral Venous Sinus Infective Thrombophlebitis Detected With 99mTc-HMPAO White Blood Cell Scintigraphy
Authors: Golmehr Sistani, Katherine A. Zukotynski, Cigdem Akincioglu, Jonathan G. Romsa, James C. Warrington
Journal: Clinical Nuclear Medicine (2020)

Abstract A 35-year-old man with a history of renal transplant, congenital cystinosis, and diabetes was admitted to the hospital with fever, bilateral parotid gland swelling, and acute renal failure. He had 99m Tc-HMPAO-WBC ( 99m Tc-hexamethylpropyleneamineoxime white blood cell) imaging for the evaluation of possible parotitis. There was intense radiopharmaceutical uptake along the right internal jugular vein extending to the right sigmoid and transverse and superior sagittal sinuses, suggestive of infective thrombophlebitis or Lemierre syndrome. This study illustrates the value of 99m Tc-HMPAO-WBC imaging as a tool for evaluating thrombophlebitis, particularly in patients with renal failure in whom contrast-enhanced CT may not be possible.
Prevalence of Familial Plasma Cell Disorders in Patients with Multiple Myeloma
Authors: Alissa Visram, Eli Muchtar, S. Vincent Rajkumar, Celine M. Vachon, Angela Dispenzieri, Prashant Kapoor, Martha Q. Lacy, Francis K. Buadi, Suzanne R. Hayman, Morie A. Gertz, Robert A. Kyle, Shaji K. Kumar
Journal: Blood (2020)
Abstract PO-123: Distinct subpopulations of osteosarcoma cells cooperate to establish lung metastases
Authors: James B. Reinecke, John M. Hinckley, Amy C. Gross, Maren Cam, Sanjana Rajan, Ryan D. Roberts
Journal: Cancer Research (2020)

Abstract Four decades of intense multinational efforts to improve outcomes for children and teenagers with osteosarcoma have failed. Today, we still treat patients with a regimen first developed in 1982. The same 35-40% of young people diagnosed with osteosarcoma die from their disease, almost always from complications related to lung metastasis. Believing that therapies targeting lung metastasis could dramatically improve outcomes, we have sought to understand the mechanisms that drive lung colonization in this disease. We previously found that interactions with lung epithelium cause osteosarcoma cells to produce IL6 and CXCL8 and that this activity is necessary for metastasis. Inhibiting IL6 and CXCL8 signaling prevents metastasis entirely in 85% of mice with osteosarcoma. While conducting these studies, we learned that individual tumor cells react differently to signals from lung epithelium. Nearly all the IL6 and CXCL8 produced by osteosarcoma cells come from a small subset of cells. Interactions with pulmonary epithelium cause this discrete subset of tumor cells to produce large quantities of inflammatory cytokines, become strongly p21+, and stop proliferating. Early metastatic lesions consist almost entirely of cells with this phenotype, positioning them to orchestrate the development of the metastatic niche. Thus, we call these hypo-proliferative, cytokine-producing cells that survive early attrition "anchor cells." In the initial stages of metastasis, anchor cells alter the surrounding lung tissue in ways that facilitate subsequent colonization by tumor cells with proliferating phenotypes ("growth cells"). Growth cells then divide to create expanding, clinically-relevant metastasis. Importantly, one can leverage the biology of these anchor cells to develop rational targeting strategies. Anchor cells exhibit profound sensitivity to known senolytic agents. Combining these with conventional therapies (which effectively target growth cells) can eradicate established metastatic lesions and prevent new metastases from forming. These novel findings fundamentally alter our understanding of osteosarcoma and metastasis biology and have direct implications for approaches to treatment. Citation Format: James B. Reinecke, John M. Hinckley, Amy C. Gross, Maren Cam, Sanjana Rajan, Ryan D. Roberts. Distinct subpopulations of osteosarcoma cells cooperate to establish lung metastases [abstract]. In: Proceedings of the AACR Virtual Special Conference on Tumor Heterogeneity: From Single Cells to Clinical Impact; 2020 Sep 17-18. Philadelphia (PA): AACR; Cancer Res 2020;80(21 Suppl):Abstract nr PO-123.
Early Mortality in Patients with Multiple Myeloma Treated with Novel Agents - Analysis from Polish Myeloma Study Group
Authors: Grzegorz Charlinski, Agata Tyczyńska, Jan M Zaucha, Adriana Czyz, Jarosław Czyż, Dominik Dytfeld, Bartosz Malecki, Lidia Gil, Szymon Fornagiel, Sebastian Grosicki, Agnieszka Barchnicka, Jadwiga Holojda, Agnieszka Kolkowska, Iwona Hus, Grzegorz Helbig, Anna Kopinska, Anna Masternak, Dariusz Woszczyk, Miroslaw Markiewicz, Jaroslaw Piszcz, Janusz Kloczko, Lidia Usnarska-Zubkiewicz, Tomasz Wrobel, Pawel J. Robak, Tadeusz Robak, Anna Waszczuk-Gajda, Grzegorz Basak, Artur Jurczyszyn
Journal: Blood (2020)
Distinct Transcriptional Signatures Distinguish the Emergence of Multipotent Progenitors and Hematopoietic Stem Cells from Endothelial Precursors in the Murine Embryo
Authors: Tessa Dignum, Barbara Varnum-Finney, Sanjay Srivatsan, Stacey Dozono, Olivia Waltner, Adam Heck, Cynthia Nourigat-Mckay, Dana Jackson, Shahin Rafii, Irwin D. Bernstein, Cole Trapnell, Brandon Hadland
Journal: Blood (2020)
Real-World Eculizumab Dosing Patterns Among Patients with Paroxysmal Nocturnal Hemoglobinuria in a US Population
Authors: Wendy Y Cheng, Sujata P. Sarda, Nikita Mody-Patel, Sangeeta Krishnan, Mihran Yenikomshian, Patrick J. Scoble, Colin Kunzweiler, Jensen Duy Vu, Hoi Ching Cheung, Mei Sheng Duh
Journal: Blood (2020)
COVID-19: B-Cell Depletion and Sepsis Related Changes in Bone Marrow and Spleen
Authors: Jana Ihlow, Ann-Christin von-Bruenneck, Edward Georg Michaelis, Selina Greuel, Verena Heynol, Annika Lehmann, Helena Radbruch, Jenny Meinhardt, Victor Max Corman, Florian Miller, Hermann Herbst, Jörg Westermann, Lars Bullinger, David Horst, Sefer Elezkurtaj
Journal: Blood (2020)
Distinct Pathogenesis of Clonal Hematopoiesis Revealed By Single Cell RNA Sequencing Integrated with Highly Sensitive Genotyping Method
Authors: Masahiro Marshall Nakagawa, Ryosaku Inagaki, Yutaka Kuroda, Yasuhito Nannya, Lanying Zhao, Yotaro Ochi, June Takeda, Qi Xingxing, Akinori Yoda, Ayana Kon, Nobuyuki Kakiuchi, Hideki Makishima, Shuichi Matsuda, Seishi Ogawa
Journal: Blood (2020)
Abstract 480: Non-muscle Myosin II Regulates Aortic Stiffness via Tension-dependent Phosphorylation of Specific Focal Adhesion Proteins
Authors: Kuldeep Singh, Anne B Kim, Kathleen G Morgan
Journal: Circulation Research (2020)

Non-muscle myosin II plays a role in many fundamental cellular processes including cell adhesion, migration, and cytokinesis. However, its role in vascular function is not well understood. Here, we investigated the function of non-muscle myosin II in the biomechanical properties of mouse proximal aorta. We found that blebbistatin, a specific inhibitor of non-muscle myosin II decreases agonist-induced aortic stress and stiffness in a dose-dependent manner. We also specifically demonstrate, in freshly isolated contractile aortic smooth muscle cells, using deconvolution microscopy that the NM myosin IIA isoform co-localizes with contractile filaments in the core of the cell as well as in the non-muscle cell cortex. However, the NM myosin IIB isoform is only colocalized with contractile filaments, and is excluded from the cell cortex. Furthermore, both the siRNA knockdown of NMIIA and NMIIB isoforms in a differentiated smooth muscle cell line A7r5 and blebbistatin-mediated inhibition of NM myosin II suppresses agonist-activated increases in phosphorylation of FAK Y925 and paxillin Y118. Thus, in the present study, we show, for the first time, that NM myosin II regulates aortic stiffness and that this regulation is mediated at least in part through the tension-dependent phosphorylation of focal adhesion proteins FAK and paxillin.
<i>Notes from the Field:</i> Development of an Enhanced Community-Focused COVID-19 Surveillance Program — Hopi Tribe, June‒July 2020
Authors: Royce Jenkins, Rachel M. Burke, Joyce Hamilton, Kathleen Fazekas, Duane Humeyestewa, Harpriya Kaur, Jocelyn Hirschman, Kay Honanie, Mose Herne, Oren Mayer, Graydon Yatabe, S. Arunmozhi Balajee
Journal: MMWR Morbidity and Mortality Weekly Report (2020)
Abstract 403: Leveraging the Zebrafish to Overcome Barriers in Heart Transplantation
Authors: Shannon N Tessier, Luciana Da Silveira Cavalcante, Casie A Pendexter, Stephanie E Cronin, Reinier J de Vries, Felix Ellett, Beatriz Marques, Kaustav Gopinathan, Samantha To, Juan Manuel Gonzalez-rosa, David M Langenau, Korkut Uygun, Mehmet Toner
Journal: Circulation Research (2020)

Cardiac transplantation is the only curative therapy for patients with end-stage heart disease; however, there is a severe shortage of viable donor organs. Heart transplantation faces many interwoven challenges, including both biological factors and research limitations. For example, ischemia-reperfusion injury plays a role in early graft dysfunction and is associated with rejection episodes in heart transplantation. Moreover, experimental transplantation relies heavily on animal studies that are laborious and expensive, prohibiting the discovery of novel, bold solutions. We propose that the zebrafish, Danio rerio , would be a valuable tool for the field since it’s amenable to high-throughput screens, captures the complex structure of organs, and offers a suite of tools to monitor the biology of cardiac injury. Here, we develop a new subzero heart preservation method by strategically leveraging animal models from zebrafish to mammalian hearts. Using zebrafish larvae, we screened for agents which preserve hearts at -10°C. As a result of these screens, we identified promising preservative cocktails which restored heartbeat in 82% of larvae immediately post-recovery. Next, we excised adult zebrafish hearts and developed methods to mimic the ex vivo handling practices of hearts destined for transplant using a heart-on-a-plate assay. Using this assay, we carried forward promising agents identified in our initial zebrafish larvae screen to isolated adult zebrafish hearts that were cooled to -10°C and held for up to 24 hours. After rewarming, heart rate was restored and metabolic rate of zebrafish hearts was like time-matched controls (0.213 ± 0.047 and 0.275 ± 0.060, respectively, p = 0.200). Finally, we report our preliminary scale-up efforts whereby rodent hearts are stored for up to 24 hours at -10°C and viability were assessed by the TUNEL assay. The data shows high viability of cardiomyocytes post-preservation, as compared to controls. In summary, we present data to illustrate our efforts in leveraging the zebrafish to aid new discoveries in subzero heart preservation. Similar efforts to model heart transplantation in zebrafish may provide a different vantage point and enable us to make advances faster.
Abstract 522: Impaired Inside-out Force Transmission in Hipsc-cardiomyocyte Model of Duchenne Muscular Dystrophy Cardiomyopathy
Authors: Gaspard Pardon, Foster Birnbaum, Asuka Eguchi, Helen M BLAU
Journal: Circulation Research (2020)

Duchenne Muscular Dystrophy (DMD) is a lethal X-chromosome linked disease that affects ~1:3500 boys and culminates in heart failure in early adulthood. DMD results from &gt;200 possible dystrophin mutations. The lack of dystrophin disrupts the anchoring of the sarcomere to the extracellular matrix (ECM), impairing cardiomyocyte function and cardiac contraction. With disease progression, the heart tissue stiffness increases as fibrosis progresses and a dilated cardiomyopathy phenotype develops. We hypothesize that disease progression accelerates because of a positive feedback loop involving fibrotic stiffening and mechanosensing. Our preliminary results show that single human-derived pluripotent stem cell (hiPSC) cardiomyocytes (CMs) with DMD mutations have a dramatically reduced ability to produce force compared to isogenic controls on stiffer substrates mimicking a fibrotic state, but not on soft healthy substrates. This stiffness-dependent contractile deficiency correlates with an increase in reactive oxygen species (ROS) and mitochondrial dysfunction, as well as other markers of cellular stress response and senescence. Here, we ask how stiffness affects the progression of DMD cardiomyopathy and aim to draw a link between the lack of dystrophin and force production deficiency in hiPSC-CMs with or without DMD mutations in an isogenic background. Using a novel assay and algorithm, we simultaneously measure extracellular force production by traction force microscopy (TFM) and single sarcomere dynamics (SSD) in single hiPSC-CMs adhered onto ECM micropatterns on top of a hydrogel of stiffness matching that of healthy (~10kPa) or fibrotic (~35kPa) tissue. We induce the single hiPSC-CMs to adopt a physiologic elongated 1:7 aspect ratio using microcontact printing of ECM protein. Using this platform, we determine how the lack of dystrophin impacts sarcomere architecture, sarcomere contractility, and force generation in the etiology of DMD cardiac disease.
Bendamustine, Obinutuzumab and Venetoclax As Induction Therapy for Untreated Mantle Cell Lymphoma
Authors: Irl Brian Greenwell, Jeffrey M. Switchenko, Kami J. Maddocks, Brad S. Kahl, Alexander F. M. Craig, Ash A. Alizadeh, Pamela B. Allen, Alena Lorretta Marbury, Alicia Escobar, Kelly Valla, Miayea Williams, Priya Parikh, Danielle Roberts, Jessica J. Neely, Alexandra Palmer, Kristie A. Blum, Jonathon B. Cohen
Journal: Blood (2020)
Thrombotic Complications in COVID-19 Patients: Low Incidence of Thrombotic Complications Among Critically Ill COVID-19 Patients in Singapore
Authors: Cheryl XQ Lim, Chuen Wen Tan, Bingwen Eugene Fan, Winnie Teo, Moon Ley Tung, Humaira Shafi, Dheepa Christopher, Shuwei Zheng, Wee Ming Peh, Stephrene Chan, Vanessa CL Chong, Christian Aledia Gallardo, Cheng Chieh Ray Chang, Li Min Ling, Jing Yuan Tan, Ken Cheah Hooi Lee, Ghee Chee Phua, Benjamin Cherng, Jenny Guek-Hong Low, Vui Kian Ho, Vishnu Prasad, Lester Jung Long Wong, Yen-Lin Chee, Kiat Hoe Ong, Lai Heng Lee, Heng Joo Ng, Eng Soo Yap
Journal: Blood (2020)
Clinical CAR-T Cell and Oncolytic Virotherapy for Cancer Treatment
Authors: Norihiro Watanabe, Mary Kathryn McKenna, Amanda Rosewell Shaw, Masataka Suzuki
Journal: Molecular Therapy (2020)

Immunotherapy has recently garnered success with the induction of clinical responses in tumors, which are traditionally associated with poor outcomes. Chimeric antigen receptor T (CAR-T) cells and oncolytic viruses (OVs) have emerged as promising cancer immunotherapy agents. Herein, we provide an overview of the current clinical status of CAR-T cell and OV therapies. While preclinical studies have demonstrated curative potential, the benefit of CAR-T cells and OVs as single-agent treatments remains limited to a subset of patients. Combinations of different targeted therapies may be required to achieve efficient, durable responses against heterogeneous tumors, as well as the microenvironment. Using a combinatorial approach to take advantage of the unique features of CAR-T cells and OVs with other treatments can produce additive therapeutic effects. This review also discusses ongoing clinical evaluations of these combination strategies for improved outcomes in treatment of resistant malignancies.
Cell Surface Proteins of B Cells and Plasmacells Are Differently Expressed in Waldenström's Macroglobulinemia (WM) Patients Vs. Subjects with Monoclonal Gammopathy of Uncertain Significance (IgMMGUS) Vs. Healthy Donors
Authors: Alessandra Trojani, Barbara Di Camillo, Luca Emanuele Bossi, Alessandra Tedeschi, Annamaria Frustaci, Alessandro Beghini, Marco Montillo, Roberto Cairoli
Journal: Blood (2020)
Risk of Early Severe Infections in Newly Diagnosed Multiple Myeloma Patients Treated with Novel Agents: A Pooled Analysis
Authors: Francesca Bonello, Mattia D'Agostino, Massimo Offidani, Maria Teresa Petrucci, Anna Marina Liberati, Francesca Patriarca, Andrea Capra, Giulia Benevolo, Gianluca Gaidano, Gregorio Barilà, Monica Galli, Elena Ponticelli, Nicola Cascavilla, Emanuele Angelucci, Stelvio Ballanti, Giuseppe Pietrantuono, Stefano Pulini, Daniele Derudas, Paolo de Fabritiis, Paolo Corradini, Concetta Conticello, Michele Cavo, Pieter Sonneveld, Mario Boccadoro, Sara Bringhen
Journal: Blood (2020)
Prevention of Venous Thromboembolism in Patients with Multiple Myeloma Receiving Immunomodulatory Therapy: Real-World Examination of the Impede Study
Authors: Grace Hwang, Audrea Szabatura, Houry Leblebjian, Anil Aktas-Samur, Jacob P. Laubach, Aric D. Parnes
Journal: Blood (2020)