tbuckley/cabot-search huggingface dataset:
Symptom monitoring and the uncertain threat of disease recurrence: A deductive thematic analysis with adolescent and young adult (AYA) cancer survivors.
Authors: Lauren C Heathcote, Nele Loecher, Sheri L. Spunt, Pamela Simon, Gary Dahl, Silvana Moiceanu, Gael Cruanes, Perri Tutelman, Lidia Schapira, Claudia Mueller, Bill Chiu, Laura Simons
Journal: Journal of Clinical Oncology (2019)

147 Background: Symptom monitoring plays an important role in both the physical and psychological challenges of surviving cancer. Anecdotally, cancer survival is characterized by uncertainty, symptom-related fear, and the interpretation of normal bodily sensations as symptomatic of cancer recurrence. This fear may lead to over-vigilance of benign bodily sensations, increasing anxiety and decreasing quality of life. Yet, there are few studies investigating how cancer survivors interpret and make sense of post-cancer symptoms. These studies are needed to guide considerations for clinical practice and the development of supportive interventions. Methods: We conducted in-depth semi-structured interviews with 18 AYA cancer survivors about how they interpret, manage, and respond to physical symptoms during survivorship. Participants were 15-25 years old. The sample was diverse in terms of disease history, ethnicity (8 Hispanic), and gender (9 females, 1 nonbinary). We conducted thematic analysis using a deductive coding scheme that was developed using our Cancer Threat Interpretation (CTI) theoretical model of cognitive, affective, and behavioral processes in post-cancer symptom perception. Results: AYA cancer survivors reported experiencing anxiety in the face of common physical sensations. These sensations were often interpreted as potential signs of recurrence or as late effects of treatment. Survivors most commonly reported worries about pain and fatigue, but also other sensations such as breathlessness. We coded participant transcripts into the following themes: biased attending towards symptoms, biased interpretations of symptoms as threatening, fear and worry about symptoms, and behavioral response to symptoms. In addition, we generated a new theme that was not previously captured in the CTI model: trust in the body. Conclusions: Knowing how to appraise and respond to symptoms such as pain is a challenge for AYA cancer survivors. This rich qualitative data provides support for the CTI model and suggests future directions. The results of this study can inform how clinicians talk to their patients about symptom monitoring after treatment ends.
Effect of hydroxyurea exposure before puberty on sperm parameters in males with sickle cell disease
Authors: L. Joseph, C. Jean, S. Manceau, C. Chalas, C. Arnaud, A. Kamdem, C. Pondarré, A. Habibi, F. Bernaudin, S. Allali, M. de Montalembert, B. Boutonnat-Faucher, J.-B. Arlet, B. Koehl, M. Cavazzana, J.-A. Ribeil, F. Lionnet, I. Berthaut, V. Brousse
Journal: Blood (2020)
How can we play together? Temporal inconsistencies in neural coding of music
Authors: Björn Vickhoff
Journal: Behavioral and Brain Sciences (2019)

Abstract If sensory organs encode environment, this code must be decoded to perception. The currently dominant theory of perception – predictive coding – assumes a “Bayesian decoder,” a probability function, which will present (to whom?) an optimal guess, given previous encodings of the environment – old codes testing new codes. Such a process would delay perception noticeably. This is inconsistent with the perception of music, which for several reasons must be direct.
Update: Interim Guidance for Health Care Providers for Managing Patients with Suspected E-cigarette, or Vaping, Product Use–Associated Lung Injury — United States, November 2019
Authors: Tara C. Jatlaoui, Jennifer L. Wiltz, Sarah Kabbani, David A. Siegel, Ram Koppaka, Michele Montandon, Susan Hocevar Adkins, David N. Weissman, Emily H. Koumans, Michelle O’Hegarty, Megan C. O’Sullivan, Matthew D. Ritchey, Kevin Chatham-Stephens, Emily A. Kiernan, Mark Layer, Sarah Reagan-Steiner, Jaswinder K. Legha, Katherine Shealy, Brian A. King, Christopher M. Jones, Grant T. Baldwin, Dale A. Rose, Lisa J. Delaney, Peter Briss, Mary E. Evans, Scott Aberegg, Carolyn S. Calfee, Sean J. Callahan, Annette Esper, Anne Griffiths, Dixie Harris, Don Hayes, Devika R. Rao, Lincoln S. Smith
Journal: MMWR Morbidity and Mortality Weekly Report (2019)

CDC, the Food and Drug Administration (FDA), state and local health departments, and public health and clinical stakeholders are investigating a nationwide outbreak of e-cigarette, or vaping, product use-associated lung injury (EVALI) (1). CDC has published recommendations for health care providers regarding EVALI (2-4). Recently, researchers from Utah and New York published proposed diagnosis and treatment algorithms for EVALI (5,6). EVALI remains a diagnosis of exclusion because, at present, no specific test or marker exists for its diagnosis, and evaluation should be guided by clinical judgment. Because patients with EVALI can experience symptoms similar to those associated with influenza or other respiratory infections (e.g., fever, cough, headache, myalgias, or fatigue), it might be difficult to differentiate EVALI from influenza or community-acquired pneumonia on initial assessment; EVALI might also co-occur with respiratory infections. This report summarizes recommendations for health care providers managing patients with suspected or known EVALI when respiratory infections such as influenza are more prevalent in the community than they have been in recent months (7). Recommendations include 1) asking patients with respiratory, gastrointestinal, or constitutional symptoms about the use of e-cigarette, or vaping, products; 2) evaluating those suspected to have EVALI with pulse oximetry and obtaining chest imaging, as clinically indicated; 3) considering outpatient management for clinically stable EVALI patients who meet certain criteria; 4) testing patients for influenza, particularly during influenza season, and administering antimicrobials, including antivirals, in accordance with established guidelines; 5) using caution when considering prescribing corticosteroids for outpatients, because this treatment modality has not been well studied among outpatients, and corticosteroids could worsen respiratory infections; 6) recommending evidence-based treatment strategies, including behavioral counseling, to help patients discontinue using e-cigarette, or vaping, products; and 7) emphasizing the importance of annual influenza vaccination for all persons aged ≥6 months, including patients who use e-cigarette, or vaping products.
England first, America second: The ecological predictors of life history and innovation—ERRATUM
Authors: Severi Luoto, Markus J. Rantala, Indrikis Krams
Journal: Behavioral and Brain Sciences (2019)

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Time-Restricted Versus Standard Duration Immunosuppression after Allogeneic Hematopoietic Stem Cell Transplantation: Results from the Prospective Randomized Phase III HOVON-96 Trial
Authors: Cornelis N. De Jong, Ellen Meijer, Katerina Bakunina, Erfan Nur, Marinus van Marwijk Kooij, Marco De Groot, Michel Van Gelder, Johan A. Maertens, Jurgen H.E. Kuball, Dries Deeren, Bronno Van Der Holt, Jan J Cornelissen, Annoek E.C. Broers
Journal: Blood (2019)
Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria
Authors: John M. Leech, Miqdad O. Dhariwala, Margaret M. Lowe, Kevin Chu, Geil R. Merana, Clémence Cornuot, Antonin Weckel, Jessica M. Ma, Elizabeth G. Leitner, Jeanmarie R. Gonzalez, Kimberly S. Vasquez, Binh An Diep, Tiffany C. Scharschmidt
Journal: Cell Host & Microbe (2019)
Pembrolizumab + chemotherapy for advanced G/GEJ adenocarcinoma (GC): The phase III KEYNOTE-062 study
Authors: H.C. Chung, Y.-J. Bang, J. Tabernero, E. Van Cutsem, C.S. Fuchs, L. Wyrwicz, K.-W. Lee, I. Kudaba, M. Garrido, H. Castro, W. Mansoor, M.I. Braghiroli, E. Goekkurt, J. Chao, Z.A. Wainberg, U. Kher, S. Shah, K. Shitara
Journal: Annals of Oncology (2019)
The nosology of systemic sclerosis: how lessons from the past offer new challenges in reframing an idiopathic rheumatological disorder
Authors: Alain Lescoat, Catherine Cavalin, Rodney Ehrlich, Claire Cazalets, Alice Ballerie, Nicolas Belhomme, Guillaume Coiffier, Marine de Saint Riquier, Paul-André Rosental, Eric Hachulla, Vincent Sobanski, Patrick Jégo
Journal: The Lancet Rheumatology (2019)
Daratumumab in Combination with Lenalidomide Plus Dexamethasone Results in Persistent Natural Killer (NK) Cells with a Distinct Phenotype and Expansion of Effector Memory T-Cells in Pollux, a Phase 3 Randomized Study
Authors: Niels Wcj Van De Donk, Homer Adams, Greet Vanhoof, Jakub Krejcik, Koen Van der Borght, Tineke Casneuf, Tina Smets, Amy Axel, Yann Abraham, Hugo Ceulmans, Frederik Stevenaert, Saad Z Usmani, Torben Plesner, Sagar Lonial, Berris van Kessel-Welmers, Henk M Lokhorst, Tuna Mutis, Nizar J. Bahlis, Jordan Schecter, Christopher Chiu, Hervé Avet-Loiseau
Journal: Blood (2017)
Multimorbidity, cancer, and symptoms: Using electronic health record data to cluster patients in multimorbidity phenotypes.
Authors: Stephanie Gilbertson-White, Sanvesh Srivastava, Yunyi Li, Elyse Laures, Seyedehtanaz Saeidzadeh, Chi Yeung, Sena Chae
Journal: Journal of Clinical Oncology (2019)

130 Background: Cancer-related symptoms are associated with decreased quality of life, increased health care utilization, and shorter life expectancy. There is limited understanding of how multiple chronic conditions (MCC) contribute to variability in symptoms experienced in the context of cancer. Data mining the EHR will allow us to use real clinical data to identify multimorbidity phenotypes based on the clinical similarity of patients. Purpose of this study is to identify distinct subgroups of patients based on the MCC and cancer diagnoses and describe differences across these subgroups. Methods: EHR data was extracted from adult patients (n=2977) newly diagnosed with cancer in 2017 at one academic medical center. The SEER cancer site/histology list was used to group cancer diagnosis. MCC present for &gt;6 months on the problem list or ICD-10 billing data were used. K-Means and K-Modes clustering procedures, with K equaling 7, were used to cluster patients based on MCC. Results: The sample consisted of 58% women, 93% white, with mean age of 62.4 (16.1) years. The most frequent cancers were GI (17%), gynecological (14%), and pulmonary (10%). The most frequent MCC were hypertension (33%), anemia (24%), and metabolic diseases (21%). Seven clusters correspond to following primary cancer sites: GI, pulmonary, urinary, gynecological, breast, endocrine, and skin. The MCC rates varied significantly across different primary sites with hypertension being present in call clusters, but anemia was present only in GI and urinary system cancers clusters. Conclusions: K-Means and K-Modes clustering procedures, with K equaling 7, produced similar clusters of cancer primary sites and MCCs, indicating our findings are stable and replicable. Our data extraction methods and clustering techniques worked well and can be expanded upon. Our next step is to repeat the data extraction and clustering analysis with the full data from the data warehouse (&gt;30,000 records). The identified multimorbidity phenotypes will be used as inclusion criteria for prospective research with patients to explore the relationships among MCCs and symptoms in the context of cancer.
Temporal Trends of Intracranial Hemorrhage Among Immune Thrombocytopenia Hospitalizations in the United States from 2007-2016
Authors: Mayank Sharma, Parth Bhatt, Marian Ayensu, Kuhoo Bhal, Fredrick Dapaah-Siakwan, Keyur Donda, Helen Oletu, Priyank Yagnik, Neel S Bhatt
Journal: Blood (2019)
Association of Comorbid Mood and Anxiety Disorders With Autism Spectrum Disorder
Authors: Alexandra C. Kirsch, Andrea R. S. Huebner, Sunil Q. Mehta, Flora R. Howie, Amy L. Weaver, Scott M. Myers, Robert G. Voigt, Slavica K. Katusic
Journal: JAMA Pediatrics (2019)

It is critical to evaluate the risk of comorbid psychiatric diagnoses to meet the needs of individuals with autism spectrum disorder (ASD).
Does Combined Immunochemotherapy with the Monoclonal Antibody Rituximab Improve Overall Survival in the Treatment of Patients with Indolent Non-Hodgkin Lymphoma? Preliminary Results of a Comprehensive Meta-Analysis.
Authors: Holger Schulz, Nicole Skoetz, Julia Bohlius, Sven Trelle, Thilo Kober, Alexander Greb, Andreas Engert
Journal: Blood (2005)
Large-Scale HLA Tetramer Tracking of T Cells during Dengue Infection Reveals Broad Acute Activation and Differentiation into Two Memory Cell Fates
Authors: Melissa Hui Yen Chng, Mei Qiu Lim, Angeline Rouers, Etienne Becht, Bernett Lee, Paul A. MacAry, David Chien Lye, Yee Sin Leo, Jinmiao Chen, Katja Fink, Laura Rivino, Evan W. Newell
Journal: Immunity (2019)
Regulatory T Cells Promote the Stemness of Acute Myeloid Leukemia Cells through IL10 Cytokine Related Signaling Pathway
Authors: Yingxi Xu, Yuling Wan, Jia Liu, Ying Wang, Saisai Li, Haiyan Xing, Kejing Tang, Zheng Tian, Qing Rao, Min Wang, Jianxiang Wang
Journal: Blood (2017)
Cardiovascular Disease Prevention at a Crossroads:
Authors: Michael J. Joyner, Nigel Paneth
Journal: JAMA (2019)

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Outcomes of in-hospital cardiopulmonary resuscitation (ICPR) for cardiac arrest in adult patients with metastatic solid cancers: A nationwide inpatient sample (NIS) database analysis from 2012 to 2014.
Authors: Sindhu Janarthanam Malapati, Sunny R K Singh, Rohit Kumar, Jibran Ahmed, Ishaan Vohra, Vatsala Katiyar, Zyad Kafri
Journal: Journal of Clinical Oncology (2019)

44 Background: Cardiopulmonary arrest is known to have a poor prognosis which is further worsened by existing co-morbidities. The prevalence of metastatic malignancy is rapidly increasing with improved cancer treatments and yet the outcomes of ICPR are not well studied in these patients. We aim to study the epidemiology, associations and outcomes in this subpopulation. Methods: Retrospective cohort analysis of the 2012 to 2014 NIS database. We included patients ≥ 18 years with the International Classification of Diseases, 9th Revision, Clinical Modification procedure codes for ICPR and diagnosis codes for solid metastatic cancers. Primary diagnosis of cardiopulmonary arrest was excluded (represents out‐of‐hospital arrest.) Primary outcome was inpatient mortality following ICPR and the factors associated were analyzed using logistic regression. Results: Amongst 1,432,240 admissions of adults with metastatic solid cancers, 0.6% (n = 8840) received ICPR, of which 82% (n = 7245) died in the same admission. Inpatient mortality following ICPR in adults without metastatic solid cancers was 68.7%. For adults with metastatic solid cancers receiving ICPR, mean age was 65.9 years, 57.7% were males and 60.6% Caucasian. Also, 11.5% of them had an inpatient palliative care encounter. On multivariate logistic regression analysis, African Americans had higher mortality than Caucasians (OR 1.5, p 0.01) while elective admission and age &lt; 50 years had lower mortality (OR 0.5, p &lt; 0.05 and OR 0.5, p 0.01 respectively.) There was no difference in mortality based on site of primary tumor, gender, day of admission, Charlson Comorbidity Index, insurance status and hospital teaching status, location or size. Conclusions: Amongst adult patients with metastatic solid cancers receiving ICPR, 82% died within the same admission. Race, age and admission type predicted mortality. Despite known poor prognosis, only 11.5% had a palliative care encounter. [Table: see text]
Assessing oncology patients’ perceptions of treatment goals.
Authors: Phuong Ngo, Brian Dong, Lisa Souders, Jetta Mull, Mohamed M. Hegazi, Xiaoyong Wu, Shesh Rai, Rebecca A. Redman
Journal: Journal of Clinical Oncology (2020)

e19160 Background: Metastatic disease is generally treated with palliative intent, but a patient’s perception of this is highly variable and dependent upon multiple factors. Our study evaluated our patients’ understanding of their treatment goal and sought to identify factors affecting it. Methods: This was a prospective study of 111 consecutive patients with stage IV solid tumor malignancies at a single institution. Patients were given a survey during a routine follow up visit. Requested information included primary site of malignancy, stage, duration of treatment, whether they think the treatment is curative, and whether they think the treatment will help them live longer and/or relieve cancer-related symptoms. Patients also provided basic demographic information such as age, gender, marital status, race and education level. Their answers regarding cancer type, stage and length of treatment were compared with their medical records. Characteristics were compared to survey responses using Pearson’s chi-square test and Fisher’s exact test. Results: Median age was 62 years with 58.6% females. Sixty-five percent of patients were married and 55.9% had college education or higher. The primary malignancies consisted of breast, gastrointestinal, genitourinary, lung, sarcoma and skin. Sixty percent were metastatic at diagnosis, 27% of patients had received adjuvant therapy, and 49.5% of patients received two or more lines of therapy in the metastatic setting. Of all patients, 91.9% correctly identified their primary cancer but only 77.5% knew it was stage IV. Only 22.5% of patients knew their treatment was not curative while 32.4% believed it was and 45% did-not-know. Seventy-three percent thought treatment would help them feel better and 85.6% believed it would help them live longer. Lines of therapy received significantly affected whether a patient thought treatment would help alleviate symptoms. Cancer type was significantly associated with whether a patient believed treatment to be curative. Marriage, age, race and education did not significantly affect patients’ answers. Conclusions: Less than one-third of our patients receiving treatment with palliative intent reported that his/her treatment was not curative. Factors influencing a patient’s perception of treatment goals are many and include those specific to the patient, their cancer and their providers. Ongoing studies will focus on identifying more barriers affecting a patients’ perceived treatment intent and will explore possible solutions to overcoming them.
Cultural interconnectedness and in-group cooperation as sources of innovation
Authors: Natalia B Dutra
Journal: Behavioral and Brain Sciences (2019)

Abstract I argue that the increased rate of innovation in eighteenth-century England cannot be understood without accounting for the unprecedented level of contact between England and other societies as a consequence of sixteenth-century colonialism. I propose cultural interconnectedness and in-group cooperation as two potential alternative explanations for the psychological changes and innovative behavior described by Baumard.
Early Disruption of VEGF Receptor Signaling and the Risk for Adult Emphysema
Authors: Timothy D. Le Cras, Steven H. Abman
Journal: American Journal of Respiratory and Critical Care Medicine (2019)

This multivariable analysis, which included all 9,238 eligible participants, yielded very similar results to those reported in our recent article (Table 1).Finally, we appreciate Dr. Liu and Dr. Zhou's comment on our definition of menopause.We used the mean age at menopause in U.S. women (51 yr) to define menopause.Indeed, average estradiol levels dropped markedly after age 50 years among women included in our analysis.In a secondary analysis, we did not find a significant interaction between menopause (as defined here) and serum estradiol on asthma in participating women.Given the comments by Dr. Liu and Dr. Zhou, we repeated the secondary analysis redefining menopause as not having had a menstrual period for at least a year ([age when interviewed/examined] -[self-reported age at the last menstrual period] >1 yr) or self-report of having had a hysterectomy in which both ovaries were removed.Using this alternative definition, we also found no significant interaction between menopause and serum estradiol on current asthma.Large longitudinal studies with precise information on menopausal status should help better understand the relation between sex hormones and current asthma in adults.
Encouraging AWaRe-ness and discouraging inappropriate antibiotic use—the new 2019 Essential Medicines List becomes a global antibiotic stewardship tool
Authors: Mike Sharland, Sumanth Gandra, Benedikt Huttner, Lorenzo Moja, Celine Pulcini, Mei Zeng, Marc Mendelson, Bernadette Cappello, Graham Cooke, Nicola Magrini, Zeba Aziz, Franco Cavalli, Elisabeth De Vries, Armando Genazzani, Monica Imi, Gregory Kearns, Gilbert Kokwaro, Gabriela J Prutsky, Nizal Sarrafzadegan, Shalini Sri Ranganathan, Fatima Suleman, Worasuda Yoongthong, Stephan Harbarth, Mark Loeb, Dominik Mertz, Evelina Tacconelli, Maria V Villegas
Journal: The Lancet Infectious Diseases (2019)