tbuckley/cabot-search huggingface dataset:
Exhaled Nitric Oxide (NO) is not elevated in patients with cystic fibrosis or bronchiectasis compared to normals
Authors: L P Ho, J A Innes, A P Greening
Journal: Thorax (1996)

Airways inflammation has been associated with increased NO in the exhaled breath (Barnes, ERJ (6), 1993). We therefore questioned whether exhaled NO could act as an indicator of the severity of airways inflammation in the suppurative lung diseases, cystic fibrosis (CF) and bronchiectasis (Br). Methods: Single exhalation NO levels were measured using the chemiluminescence NO analyser (Logan Research, Kent); detection limit 0.3ppb. Upper airway NO production was excluded by maintaining a constant mouth pressure (4-5 cm H2O) during exhalation. This pushes back the soft palate and excludes air originating from the nose during exhalation. Values quoted are plateau levels at the end of exhalation, against a flow restrictor. Patients. All patients were recruited from our outpatient clinics. All except 3 CF patients have fully defined genotypes. Br was diagnosed by CT or classical CXR changes. All subjects were non smokers. 6 asthmatics were on inhaled steroids. All levels were taken when patients were stable. Results: normal CF Br Br+ster Asthma n=17 n=31 n=6 n=5 n=7 NO 5.5 (3.6) 4.5(2.6) 6.6(3.4) 5.9(1.4) 15.0(6.1) Age 32.8(16.1) 27.2(8.7) 49.3(8.4) 57.8(13.3) 39.6(16.3) FEV1 - 54.4(24.1) 61.0(22.8) 57.8(13.3) (All values are mean (SD), NO in ppb. Br= Bronchiectasis, Ster= inhaled fluticasone, budesonide or beclomethasone, FEV1 = % predicted.) These data suggest that NO in the exhaled breath of patients with CF and Br, in contrast to asthma, are not elevated. Explanations include a) poor diffusion of NO across increased and viscous airway secretion b) down regulation of iNOS in chronic suppurative conditions. Our findings in bronchiectasis contrast with those of Kharitonov et al (AJRCCM (151) 1995). This may be due to different methodologies.
Forward-viewing echoendoscope is useful for recanalization of postoperative biliary anastomotic atresia in endosonography-guided biliary drainage
Authors: Takehiro Shimizu, Ken Sato, Takahiro Abe, Dan Zennyoji, Katsutoshi Ishida, Koki Hoshi, Toshio Uraoka
Journal: Endoscopy (2020)

One possible cause of biliary peritonitis and stent migration as adverse events of transgastrohepatic endosonography-guided biliary drainage (EUS-BD) [1] is a puncture site in the stomach wall and liver that is not fixed. Magnetic compression anastomosis (MCA) is applied to fix two organs, the gastrointestinal tract and the bile duct [2] [3]. Herein, we present an alternative technique to fix these organs without MCA through recanalization of postoperative biliary anastomotic atresia with EUS-BD using a forward-viewing echoendoscope.
Preoperative core needle biopsy does not increase local recurrence rate in breast cancer patients
Authors: F. Fitzal, E. Sporn, W. Draxler, S. Taucher, M. Rudas, M. Gnant, R. Jakesz
Journal: Journal of Clinical Oncology (2005)

815 Objective: Several case reports and clinical studies in the literature demonstrate needle track seeding after core needle biopsy in patients with breast cancer in up to 50% of cases. The impact of this observation on local recurrence and overall survival rate is, however, not fully investigated. Patients and Design: We retrospectively analysed 719 patients after breast conserving surgery and postoperative radiotherapy for stage I and II breast cancer. 189 had preoperative core needle biopsy. Demographic data, local recurrence and overall survival rate were compared between these two groups. Result: Preoperative core biopsy did not significantly influence the local free recurrence rate while overall survival was significantly improved in patients with preoperative core biopsy (median follow-up time of 78 and 71 months, respectively). The demographic data and the postoperative therapy did not differ significantly between the two groups. Conclusion: Preoperative core needle biopsy seems to be without any detrimental impact on local recurrence and overall survival after breast conserving surgery and postoperative radiotherapy. No significant financial relationships to disclose.
Tumor regression by means of magnetic drug targeting.
Authors: Manfred Georg Krukemeyer, Wolfgang Wagner, Veit Krenn
Journal: Journal of Clinical Oncology (2014)

e14014 Background: Systemic chemotherapies in patients with liver metastases are often not suitable for many, especially elderly patients due to toxicity and side effects, however patients with a limited general condition may possibly benefit from a systemic applied but locally acting therapy.The objective of this pilot study was the development of a therapy in which classical cytostatics are coupled with liquid iron oxides (Fe3O4) and concentrate via bloodstream selectively in the reticuloendothelial system (RES) in the liver and therefore result in a local treatment. The effect of this procedure was intensified by an external docked magnet.This concept was tested successfully in an animal model. Methods: A 70-year old female patient with metastasized and exulcerated mammary carcinoma which could not be ablated due to a poor general condition and multiple liver metastases. Therefore a systemic therapy was out of question. The patient agreed to this experimental therapy consisting of mitoxantrone-iron oxide (Fe3O4), coupled with mitoxantrone in the dosage 20 mg/m² body weight. Results: The mixantrone-iron concentration in plasma was significantly lower compared to the liver. The medical imaging showed a clearly visible iron accumulation in the completely metastasized liver without any necrosis indications 7 days after the treatment. No allergies or toxic reactions were observed. Consecutively the medical imaging showed a partial remission of the metastases. Therefore and due to improved liver values the patient became suitable for anaesthetic and the ulcerated mamma was ablated. The patient survived with the residual metastases without progression approx. 2 ½ years and died independently from the tumor. Conclusions: In this case it has been demonstrated that a basically systemtic therapy resulted in a local chemotherapy accumulation in the liver by means of coupling it to liquid iron in combination with the application of an external magnet. Therefore the local effect onto the multiple metastases was higher and side effects have not been registrated. Afterwards a partial remission has been observed and the terminally ill woman survived for more than 2 years. A larger patient collective should be treated with this concept within a phase-II-study.
UNROOFING TECHNIQUE: LARGE ULCERATED COLONIC LIPOMA MIMICKING MALIGNANCY
Authors: A Santos Rodriguez, P Garcia Centeno, MV Cives, David Del Pozo Prieto, IM Medina Exposito, E Poves Martinez
Journal: Endoscopy (2020)

A 50-year-old man presented with abdominal pain and intermittent rectorrhagia. Abdominal computed tomography showed a homogenous low-density mass measuring 32 x35mm at descending colon. A colonoscopy revealed a 35mm ulcerated mass. We performed an unroofing resection with a 20 mm electrocautery snare (SD-230U-20, Olympus). Fat tissue was observed extruding from the cut surface. It was subsequently extracted from the open surface with a cold snare. Preventive hemostasis was performed by clipping with a Padlock Clip and convencional endoclips. Histopathological examination revealed an adipose tissue There were no procedure-related complications. The unroofing technique is suitable for the treatment of large lipomas.
DIGITAL-SINGLE-OPERATOR PERORAL CHOLANGIOSCOPY GUIDED BIOPSY VS. ERCP GUIDED BRUSHING FOR INDETERMINATE BILIARY STRICTURES - A PROSPECTIVE, RANDOMIZED MULTICENTER TRIAL
Authors: C Gerges, T Beyna, RSY Tang, F Bahin, JYW Lau, E van Geenen, T Dertmann, H Neuhaus, N Reddy, M Ramchandani
Journal: Endoscopy (2020)

Aims Accurate diagnosis of indeterminate biliary strictures is challenging but important for patient prognostication and further management. Biopsy under direct cholangioscopic vision might be superior to standard endoscopic retrograde cholangiopancreatography (ERCP) techniques such as brushing or biopsy. Our aim was to investigate whether digital single operator cholangioscopy (DSOC) compared to standard ERCP work-up improves the diagnostic yield in patients with indeterminate biliary strictures.
OUTCOMES OF NEEDLE KNIFE FISTULOTOMY AS AN INITIAL METHOD OF BILIARY CANNULATION
Authors: J Fernandes, G Alexandrino, M Moreira, T Araújo, D Horta, L Lourenço, L Lopes, J Canena
Journal: Endoscopy (2020)

Aims A previous feasibility study has suggested that needle knife fistulotomy (NFK) as an initial method for biliary access in patients with stones is associated with high levels of success and low rate of complications. This study evaluated the outcomes of NKF as an initial method for biliary access, in a large number of patients with any type of biliary pathology (tumors and stones),on the basis of success rate, complications and factors associated with success and complications.
COMPARATIVE STUDY BETWEEN URINASTATIN AND NAFAMOSTAT MESYLATE FOR THE PREVENTION OF POST-ERCP PANCREATITIS
Authors: D Kang, JW Lee, HW Kim, S Park, S Kim
Journal: Endoscopy (2020)

Aims A pancreatitis is a major complication of ERCP. Nafamostat mesylate (Futhan) and Urinastatin (Ulistin) are commonly used to prevent and treat pancreatitis in Korea. The aim of our study is to compare the efficacy of Nafamostat Mesilate and Urinastatin for post ERCP pancreatitis (PEP) prevention.
ENDOSCOPIC SUBMUCOSAL DISSECTION OF A RECTUM POLYP WITH THE DOUBLE - ENDOSCOPE - ASSISTED - TRACTION METHOD
Authors: A Ebigbo, G Tziatzios, SK Gölder, A Probst, H Messmann
Journal: Endoscopy (2020)

We present the case of a 49-year-old patient with a 5 cm laterally spreading tumor(LST) - mixed type in the rectum. The lesion is initially marked, injected and incised circularly. A thin pediatric gastroscope (5.5mm outer diameter) is introduced, which with the help of a biopsy forceps optimized traction of the submucosa during ESD. This allowed an easier and faster submucosal dissection. The procedure was uncomplicated and lasted about 80 minutes. Patient`s clinical course remained uneventful. ESD with the “Double Endoscope Traction” method is a feasible, technically simple procedure.
Venous thromboembolism in SARS-CoV-2 patients: only a problem in ventilated ICU patients, or is there more to it?
Authors: Maarten Criel, Maarten Falter, Jasmien Jaeken, Margaretha Van Kerrebroeck, Isabelle Lefere, Liesbeth Meylaerts, Dieter Mesotten, Margot vander Laenen, Tom Fivez, Michiel Thomeer, David Ruttens
Journal: European Respiratory Journal (2020)

<b>Insidious</b><b>venous thromboembolism (VTE) is mainly a problem in ICU-ventilated SARS-CoV-2 patients, while patients in the general ward, treated with thromboprophylaxis (0.5 mg·kg<sup>−1</sup>), had a low incidence of insidious VTE</b>https://bit.ly/2Yl8jft
Targeted Therapy Against All Three VEGF Receptors by Cediranib Enhances the Antitumor and Anti-metastatic Effects of Paclitaxel and Radiation in an Orthotopic Human Lung Cancer Model
Authors: O Takahashi, R Komaki, R Tailor, J M Juergensmeier, A Ryan, P D Smith, J J Jacoby, M V Korshunova, R S Herbst, M S O'Reilly
Journal: Journal of Thoracic Oncology (2010)
Coding of Acute Myocardial Infarction
Authors: Lisa I. Iezzoni
Journal: Annals of Internal Medicine (1988)

Study Objective: To evaluate the appropriateness of diagnostic coding of acute myocardial infarction across teaching and nonteaching hospitals. Design: Retrospective review of a random sample of medical records to find evidence of the occurrence and active treatment of acute myocardial infarction during the admission. Setting: Five tertiary teaching, five other teaching, and five nonteaching hospitals in metropolitan Boston. Cases: Random sample of hospital admissions assigned a discharge diagnosis of acute myocardial infarction between October 1984 and September 1985. Measurement and Main Results: Of the 1003 cases reviewed, 260 did not meet the clinical criteria for acute myocardial infarction. At tertiary hospitals, 175 (41.7%) failed to qualify, compared with 25 (9.1%) at nonteaching facilities. In a large fraction of the disqualified cases, the patients had been admitted to exclude the diagnosis of acute myocardial infarction; although explicitly "ruled out," an acute myocardial infarction code was assigned. Sixty-six cases from teaching hospitals did not qualify because the patient had been admitted only for coronary angiography after an uneventful postmyocardial infarction course. Almost one-third of these patients had had their infarcts from 5 to 8 weeks before the angiography admission. Conclusions: Cases with an inappropriate discharge diagnosis of acute myocardial infarction may be concentrated in teaching hospitals. This finding could have implications for Medicare's diagnosis-related group payment system and governmental and other research efforts that use these data for such purposes as drawing inferences about the quality of hospital care.
The effect of a dermato‐oncological training programme on the diagnostic skills and quality of referrals for suspicious skin lesions by general practitioners*
Authors: E. Marra, M.C.J. van Rijsingen, J.A.C. Alkemade, J.M.M. Groenewoud, K.F. Hueskes, C.H.M. Nij Bijvank, F.A. van de Laar, S.F.K. Lubeek
Journal: British Journal of Dermatology (2020)

The rising incidence rates of skin cancer (SC) lead to an enormous burden on healthcare systems. General practitioners (GPs) might play an important part in SC care, but research has shown poor clinical recognition of SC, leading to a high rate of potentially unnecessary referrals. The aim of this study was to evaluate if a dermato‐oncological training programme (DOTP) for GPs improved their diagnostic skills and quality of referrals. Out of 194 GPs in the Nijmegen area, 83 (42·8%) followed a DOTP on SC. Referrals from both a trained cohort (TC) and two cohorts of untrained GPs [untrained present cohort (UPC) and untrained historical cohort (UHC)] were included. Data on diagnostic skills, quality of referrals and the number of potentially unnecessary referrals were evaluated. A total number of 1662 referrals were analysed. The referral diagnosis was correct more often in the TC (70·3%) compared with the UPC (56·2%; P < 0·001) and the UHC (51·6%; P < 0·001). Furthermore, the TC also provided a better lesion description, mentioned a diagnosis more often in their referral letters and more often performed diagnostics before referral. In addition, fewer potentially unnecessary referrals were identified in the TC compared with the UPC (62·7% vs. 73·7%; P < 0·001) and the UHC (75·2%; P < 0·001). GPs who followed a DOTP had better diagnostic skills and quality of referrals than untrained GPs, leading to fewer potentially unnecessary referrals. This might enhance a more efficient use of the limited capacity in secondary dermatological care and consequently lead to lower healthcare costs.
PREDICTIVE FACTORS OF ENDOSCOPIC RECURRENCE AFTER ILEOCOLIC RESECTION FOR CROHN´S DISEASE
Authors: F Errabie, H Koulali, W Khannoussi, A Elmekkaoui, Z Ismaili, G Kharrasse
Journal: Endoscopy (2020)

Aims To evaluate the risk factors for endoscopic recurrence after bowel resection in Crohn´s disease (CD).
EFFICACY OF HEMOSTATIC POWDERS IN THE TREATMENT OF GASTROINTESTINAL BLEEDING RELATED TO NEOPLASTIC OR NON-NEOPLASTIC LESIONS
Authors: C Cardamone, OA Paoluzi, A Aucello, E Grasso, M Giannelli, L Baiocchi, MC Fantini, G Monteleone, GDV Blanco
Journal: Endoscopy (2020)

Aims EndoClot System and Hemospray are two hemostatic powders (HPs) recently introduced in the treatment of gastrointestinal bleeding (GIB). Aim of the study was to evaluate the efficacy and safety of HPs in the management of GIB.
Transcriptional and Cellular Diversity of the Human Heart
Authors: Nathan R. Tucker, Mark Chaffin, Stephen J. Fleming, Amelia W. Hall, Victoria A. Parsons, Kenneth C. Bedi, Amer-Denis Akkad, Caroline N. Herndon, Alessandro Arduini, Irinna Papangeli, Carolina Roselli, François Aguet, Seung Hoan Choi, Kristin G. Ardlie, Mehrtash Babadi, Kenneth B. Margulies, Christian M. Stegmann, Patrick T. Ellinor
Journal: Circulation (2020)

The human heart requires a complex ensemble of specialized cell types to perform its essential function. A greater knowledge of the intricate cellular milieu of the heart is critical to increase our understanding of cardiac homeostasis and pathology. As recent advances in low-input RNA sequencing have allowed definitions of cellular transcriptomes at single-cell resolution at scale, we have applied these approaches to assess the cellular and transcriptional diversity of the nonfailing human heart.
GIANT AMPULLOMA, RESECTION WITH HOT SNARE POLLIPECTOMY AND CLOSING WITH SHORT STEM CLIP
Authors: E Pijoan, S Bazaga, M Pérez, I Miguel, G Torres, N Zaragoza, T Revuelto, R Ballester, JM Reñe, F Gonzalez-Huix
Journal: Endoscopy (2020)

A 59-year-old woman underwent a routine gastroscopy showed a 5 cm polypoid lesion in papillary area. Performed a piece-meal resection in 2 pieces and recovered for histological examination. Pancreatic duct cannulated and 5Fx7 cm plastic stent placed. Bile duct cannulated and common bile duct dilatation of 12 mm without pathologic content and placed a 10 Fx5 cm plastic stent, with spontaneous bile outflow. After resection 2 visible nonbleeding vessels, placing a short stem clip in one and 2 large stem clips in the other and injecting adrenalin. Long stem clips can unwittingly release when using the duodenoscope elevator system. 9 months follow-up without lesion recurrence.
EFFICACY OF UNCOVERED COLONIC STENTS FOR EXTRINSIC VERSUS INTRINSIC MALIGNANT LARGE BOWEL OBSTRUCTION
Authors: BR Weston, JM Patel, M Pande, PJ Lum, WA Ross, GS Raju, PM Lynch, E Coronel, PS Ge, JH Lee
Journal: Endoscopy (2020)

Aims Previous studies evaluating self-expandable metal stents (SEMS) for management of malignant extrinsic colon obstruction have yielded conflicting results. We evaluated the efficacy of uncovered colonic stent placement for patients with extrinsic colon malignancy (ECM) versus intrinsic colon malignancy (ICM).
ENDOSCOPIC VACUUM-ASSISTED THERAPY IN THE MANAGEMENT OF POST-POEM ISCHEMIC ULCER FOLLOWED BY POSTSURGICAL ESOPHAGOGASTRIC ANASTOMOTIC LEAKAGE
Authors: C Robles-Medranda, R Oleas, J Alcivar-Vasquez, A Bellido, C Cifuentes, H Pitanga-Lukashok
Journal: Endoscopy (2020)

Endoscopic therapy such as clip deployment, suturing and stenting are alternatives for the management of upper gastrointestinal leakages. Other options include management by EVAC therapy, that showed superior results over stenting, with a higher closure rate and lower mortality.
ENDOSCOPIC MANAGEMENT OF BILE LEAKS: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: A Tringali, E Piovesana, F Pozzato, M Rinaldi, A Graziotto, D Adler
Journal: Endoscopy (2020)

Aims The endoscopic treatment of biliary leaks is based on a variety of techniques, including sphincterotomy, stenting, a combination of both techniques, or placement of a nasobiliary drainage. We performed a systematic review and meta-analysis to define the best strategy.
PROXIMAL AND DISTAL FINDINGS DURING COLORECTAL SCREENING PROGRAMME: MULTICENTER STUDY
Authors: MH Núñez-Rodriguez, PD Redondo, F Riu, M Cimavilla, RS Ocaña, A Loza, L Hernandez, M Perez-Miranda
Journal: Endoscopy (2020)

Aims Faecal immunochemical test (FIT) is used for colorectal cancer screening. The aim of this study is describe findings in the distal and proximal colon in a FIT colorectal screening programme and its relationship with FIT value.
Covid-19: Questions remain over UK government’s PPE guidance
Authors: John Puntis
Journal: BMJ (2020)

Staff should not need to fight for adequate protection at work, but the legal challenge launched against NHS England’s guidance is surely born of desperation.1

Initially the management mantra was that there were adequate national supplies of personal protective equipment (PPE) but problems with local distribution.2 When this became untenable, staff were blamed for using up PPE inappropriately.3 The narrative then changed to: “We share your pain and have done our utmost, …
Covid-19: Surveys indicate low infection level in community
Authors: Jacqui Wise
Journal: BMJ (2020)

Covid-19: Surveys indicate low infection level in communityJacqui Wise London Just 0.27% of people-one in 370-are estimated to have had covid-19 outside of hospitals and care homes in England in the past two weeks, say the preliminary results of a snapshot survey published by the Office for National Statistics (ONS).
Establishing the Prevalence and Prevalence at Birth of Hemophilia in Males
Authors: Alfonso Iorio, Jeffrey S. Stonebraker, Hervé Chambost, Michael Makris, Donna Coffin, Christine Herr, Federico Germini
Journal: Annals of Internal Medicine (2019)

The large observed variability in hemophilia prevalence prevents robust estimation of global burden of disease. This study estimates male prevalence and prevalence at birth of hemophilia and the as...
RISK ESTIMATE OF DUODENOSCOPE-ASSOCIATED INFECTIONS (DAI) IN THE NETHERLANDS
Authors: J Kwakman, M Vos, M Bruno
Journal: Endoscopy (2020)

Aims The likelihood of endoscopy-associated infections (EAI) is often referenced from a paper by Kimmery et al. (1993), proclaiming a risk of 1 exogenous infection for every 1.8 million endoscopies (0,00006%). Ofstead et al. pointed out that this was at least an underestimation by 6-fold, however, the original calculation is still often referred to. Multiple outbreaks of multi-resistant microorganisms (MDRO) related to contaminated duodenoscopes have been reported worldwide, leading to the assumption that the former risk calculation is indeed incorrect. We aim to calculate the duodenoscope-associated infection (DAI) risk for the Dutch ERCP practice.
EMERGENCY ENDOSCOPIC TREATMENT OF A MASSIVE UPPER GASTROINTESTINAL BLEEDING OF VERY UNCOMMON ORIGIN
Authors: S Sferrazza, M Maida, F Vieceli, G de Pretis, A Lisotti, P Fusaroli
Journal: Endoscopy (2020)

A 70-year-old man was admitted to our unit in March 2018 for hematemesis with severe anemia and hypovolemic shock.
OTSC AND STENTS IN PATIENTS WITH POST-SURGICAL LEAKS INVOLVING THE LOWER GASTROINTESTINAL TRACT: A SINGLE CENTER ANALYSIS OVER A 10 YEAR PERIOD
Authors: A Caruso, S Russo, G Masciangelo, H Bertani, S Mangiafico, G Grande, P Flavia, S Cocca, R Conigliaro
Journal: Endoscopy (2020)

Aims Post-surgical fistula following gastrointestinal surgery may represent a dreadful event, associated both to high morbidity, mortality and increased health costs. We described a large series of patients with post-surgical leaks involving the lower gastrointestinal tract managed endoscopically.
USE OF ARTIFICIAL INTELLIGENCE TO IMPROVE POLYP DETECTION RATE
Authors: LG Pravia, MV Romero, GM Villarejo, FG Rodríguez, JLM Hernández, FS Ceballos, NL Palacios, SF Díez, ER Díaz-Rubio, JM Esteban López-Jamar
Journal: Endoscopy (2020)

Methods Seven patients underwent two consecutive colonoscopic examinations by two different endoscopists blind to each other, first one using high definition (HD) and the second one using AI.
REAL LIFE EXPERIENCE WITH THE USE OF A HEMOSTATIC POWDER IN 152 PATIENTS UNDERGOING URGENT ENDOSCOPY FOR GASTROINTESTINAL BLEEDING
Authors: A Becq, C Houdeville, ML Tran Minh, N Steuer, D Danan, MA Guillaumot, EA Ali, M Barret, A Amiot, N Carbonell, P Marteau, U Chaput, X Dray, M Camus
Journal: Endoscopy (2020)

Aims In the recent years, topical hemostatic powders have been used for the management of upper gastrointestinal bleeding (UGIB). The aim of this study was to report on the use of an hemostatic powder (TC-325) in a non-working hour context by an on-call endoscopist during urgent endoscopic procedures.