tbuckley/cabot-search huggingface dataset:
The relationship between collapsin response mediator protein-1 (CRMP 1) expression and histopathogic parameters and survival in patient with gastric cancer.
Authors: Mahmut Gumus, Nurgul Yasar, Sibel Kayahan, Sinemis Yuksel, Ozlem Balvan, Aslihan Guven Mert, Nur Dinc, Dincer Aydin, Kubra Aydin, Hatice Odabasi, Taner Korkmaz, Mehmet Aliustaoglu
Journal: Journal of Clinical Oncology (2013)

e15100 Background: Biomarkers which indicate invasion and metastasis in patients with gastric cancer are important. Collapsin response mediator protein (CRMP) family proteins are cytosolic phosphoproteins involved in semaphorin 3A-mediated neuronal cell growth cone collapse and cancer invasion. CRMP1 over expression levels were found to have negative association with invasion and metastasis in lung cancer tissue samples. The aim of the study was to investigate relationship between CRMP1 expression and histopathological parameters and prognostic value of CRMP1 expression in patients with gastric cancer. Methods: We analyzed 52 patients who were diagnosed with gastric cancer. The CRMP1 expression was examined by performing immunohistochemical staining. High CRMP1 expression in gastric tumor samples was defined as being immunoreactive to CRMP1 antibody in more than 50% of the cancer cells. The correlation between CRMP1 expression and age, gender, tumor grade, lenfovascular-perineural invasion, t stage and nodal involvement was investigated. Results: Among the 52 patients (CRMP1 positive/CRMP1 negative= 24/28), median age was 56 years (27-84). Thirty-five patients were male and 17 patients were female. The median follow-up time was 14 (2-60) months. The median disease-free survival time (DFS) was 20 (SE: 4; 95% CI: 13-27) months. In addition, the median overall survival time (OS) was not reached. The significant relationship was found between CRMP1 high expression levels and high grade tumors (p:0.03), and nodal metastasis (p:0.019). In univariate analysis, only high CRMP1 expression was associated with poor disease-free survival (p:0.004). Also, male gender (p:0.023), high grade tumors (p:0.044), nodal involvement (p:0.028) and high CRMP-1 expression were associated shorter overall survival. In multivariate analysis, no independent prognostic factor was found in this group. Conclusions: We found that high expression of CRMP1 was associated with tumor aggressiveness of tumor and poor survival. Larger studies and further clinical trials are warranted to confirm these findings.
Asthma deaths rise 33% in past decade in England and Wales
Authors: Gareth Iacobucci
Journal: BMJ (2019)

Deaths from asthma in England and Wales have increased by a third in the past decade, a new analysis has shown.

The analysis of official figures from the Office for National Statistics, released by the charity Asthma UK on 9 August, shows that more than 1400 adults and children died from asthma attacks in 2018, an 8% increase since 2017.

Overall, more than 12 700 people have died from asthma in England and Wales in the past decade. Deaths increased by 33% during 2008-18.

The charity emphasised the need for improvement in basic areas of care, such …
Safety and immunogenicity of the chlamydia vaccine candidate CTH522 adjuvanted with CAF01 liposomes or aluminium hydroxide: a first-in-human, randomised, double-blind, placebo-controlled, phase 1 trial
Authors: Sonya Abraham, Helene B Juel, Peter Bang, Hannah M Cheeseman, Rebecca B Dohn, Tom Cole, Max P Kristiansen, Karen S Korsholm, David Lewis, Anja W Olsen, Leon R McFarlane, Suzanne Day, Sara Knudsen, Kjersti Moen, Morten Ruhwald, Ingrid Kromann, Peter Andersen, Robin J Shattock, Frank Follmann
Journal: The Lancet Infectious Diseases (2019)
Association of human papillomavirus infection with risk for rheumatoid arthritis: a population-based cohort study
Authors: Yen-Tze Liu, Hsi-Kai Tsou, Jeng-Yuan Chiou, Yu-Hsun Wang, Ming-Chih Chou, James Cheng-Chung Wei
Journal: Annals of the Rheumatic Diseases (2019)

Rheumatoid arthritis (RA) is an autoimmune disease caused by genetic and environmental factors. Infection is proposed to contribute to the pathogenesis.1 Several viral and bacterial infections, including parvovirus B19, Chikungunya, hepatitis C, Epstein-Barr virus and Porphyromonas gingivalis , have been raised to be associated with RA.1 The mechanism of how infections affect RA remains undetermined, generally considered to be via molecular mimicry and cross-reactions between self-antigens and viral proteins.1 Furthermore, recent study postulates that RA may be the result of immunosenescence, meaning premature ageing of the immune system via various mechanisms including telomere shortening.2 A recent review article illustrates that the expression of human telomerase reverse transcriptase was influenced by human papillomavirus (HPV) E6/E7.3 Therefore, immunosenescence caused by telomere shortening may be another hypothetical mechanism in RA development followed by HPV infection.

HPV infections have been found to be associated with autoimmune diseases including systemic lupus erythematosus and RA.4 5 …
Geographic disparities in care: The Maryland gynecologic oncology experience.
Authors: Saroj Fleming, Selma Amrane, Gautam G. Rao, Sarah Madhu Temkin
Journal: Journal of Clinical Oncology (2012)

e16546 Background: Women with gynecologic malignancies require highly specialized care that is often unavailable at local centers. Prior reports have suggested that distance from residence to treatment facility is a barrier to care. We hypothesize that insurance status influences the distance women travel to receive gynecologic cancer care. Methods: Patients with incident gynecologic cancer diagnoses at a single urban, academic Institution were identified. Distance from the patients’ homes to the hospital was calculated in miles as well as time. Insurance status at diagnosis was captured as private (P), Medicaid (MA), Medicare (MC) or uninsured (UI). Results: 153 patients were identified. The median distance travelled to the hospital was 18.1 miles with a median time travel of 28 minutes. 48 (31%) of patients were insured by P, 42 (27%) by MA, 35 (23%) by MC and 28 (18%) were UI. Patients with MC were older than those with MA, P or UI (p&lt;0.01). Patients with P were more likely to present with cancer of the uterine corpus (p&lt;0.01). African American women were more likely to be covered by MA than other racial groups (p&lt;0.01). Rates of medical comorbidities (obesity, diabetes and hypertension) were similar between insurance groups, although there was a trend towards higher body mass index in UI (p=0.08). Mean distance and time to the hospital by insurance category is shown in Table 1. The distances and times were different between groups (p=0.04, p=0.03 respectively). These differences remained significant when adjusted for site of primary disease and race (p&lt;0.01). Adherence with treatment recommendations was similar regardless of insurance status or distance travelled. Conclusions: Insurance status plays a role in the distance women travel to receive gynecologic cancer care. The neediest patients may be shouldering an unfair burden in terms of access to specialty oncology treatments. [Table: see text]
Abstract #1012: p53 overexpression and colorectal cancer
Authors: Xuejuan Jiang, Anirban Mitra, Jose Castelao, Shanyan Xue, Anh Diep, Robert Haile, Manuela Gago-Dominguez
Journal: Cancer Research (2009)

Background: The p53 tumor suppressor gene is involved in numerous cellular processes including apoptosis. p53 overexpression has been associated with poor prognosis in colorectal cancer (CRC). Within the Colon Cancer Family Registry (CCFR) Consortium, we sought to evaluate whether p53 overexpression was associated with different characteristics of CRC. Methods: Immunohistochemical measurement of p53 expression has been conducted on 929 histopathologically-confirmed CRC cases from the CCFR. Five-micronsections of paraffin-embedded formalin fixed tissues were stainedfor p53 using primary monoclonal mouse antibody DO-7 (Dako, Carpinteria, CA). Positive antigenicity was recognized by brown DAB staining and percentage of positively stained tumor cells were counted on an automatic cellular imaging system (Clarient Inc.).by 2 trained pathologists. Microsatellite instability (MSI) status was evaluated for a panel of 10 markers. Tumors were classified as MSI-high (MSI-H) if \#8805;30% markers were instable, MSI-low (MSI-L) if 0  Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 1012.
Effects of relaxin-induced collagen remodeling on electric field-mediated gene delivery
Authors: Joshua Henshaw, Brian Mossop, Fan Yuan
Journal: Cancer Research (2008)

1394  Interstitial transport is a rate-limiting step in plasmid DNA (pDNA) delivery in solid tumors. To enhance the transport, investigators have used pulsed electric fields to push pDNA through tumor tissues in vivo. However, the extent of pDNA movement is still limited, presumably due to the collagen component in extracellular matrix, which has been observed to be a major barrier to macromolecular transport. Therefore, we investigated effects of collagen remodeling on interstitial electrophoresis by pre-treatment of tumor bearing mice with a recombinant human relaxin (rh-Rlx), a peptide hormone known to induce interstitial collagen remodeling in solid tumors. In this study, two tumor lines (4T1 and B16.F10) in two different murine tumor models -- dorsal skin-fold chamber (DSC) and hind leg -- were examined. Effects of rh-Rlx on pDNA electrophoresis were measured either directly in the DSC model, or indirectly in the hind leg model via reporter gene expression. It was observed that rh-Rlx treatment reduced collagen levels in the hind leg tumors but not in the DSC tumors. This finding correlated with the results from mobility experiments, where rh-Rlx treatment enhanced gene expression in 4T1 hind leg tumors but did not increase the mobility in the DSC model. In addition, it was observed that pDNA-collagen binding could significantly limit interstitial transport. Taken together, the study demonstrated that relaxin could reduce collagen content and enhance transgene expression in hind leg tumors but had minimal effects on collagen content and pDNA electromobility in DSC tumors, suggesting that relaxin-induced enhancement in gene delivery was correlated with reduction in collagen content in solid tumors.
Combination of Surgery With Extensive Intraoperative Peritoneal Lavage for Patients With Advanced Gastric Cancer
Authors: Yoshiaki Kanemoto, Tomohiro Kurokawa, Tetsuya Tanimoto
Journal: JAMA Surgery (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Effects of nutritional supplementation and home visiting on growth and development in young children in Madagascar: a cluster-randomised controlled trial
Authors: Emanuela Galasso, Ann M Weber, Christine P Stewart, Lisy Ratsifandrihamanana, Lia C H Fernald
Journal: The Lancet Global Health (2019)

Evidence from efficacy trials suggests that lipid-based nutrient supplementation (LNS) and home visits can be effective approaches to preventing chronic malnutrition and promoting child development in low-income settings. We tested the integration of these approaches within an existing, large-scale, community-based nutrition programme in Madagascar.We randomly allocated 125 programme sites to five intervention groups: standard-of-care programme with monthly growth monitoring and nutrition education (T0); T0 plus home visits for intensive nutrition counselling through an added community worker (T1); T1 plus LNS for children aged 6-18 months (T2); T2 plus LNS for pregnant or lactating women (T3); or T1 plus fortnightly home visits to promote and encourage early stimulation (T4). Pregnant women (second or third trimester) and infants younger than 12 months were enrolled in the trial. Primary outcomes were child growth (length-for-age and weight-for-length Z scores) and development at age 18-30 months. Analyses were by intention to treat. The trial was registered with the ISRCTN registry, number ISRCTN14393738.The study enrolled 3738 mothers: 1248 pregnant women (250 women in each of the T0, T1, T2, and T4 intervention groups and 248 in the T3 intervention group) and 2490 children aged 0-11 months (497 children in T0, 500 in T1, 494 in T2, 499 in T3, and 500 in T4) at baseline who were assessed at 1-year and 2-year intervals. There were no main effects of any of the intervention groups on any measure of anthropometry or any of the child development outcomes in the full sample. However, compared with children in the T0 intervention group, the youngest children (<6 months at baseline) in the T2 and T3 intervention groups who were fully exposed to the child LNS dose had higher length-for-age Z scores (a significant effect of 0·210 SD [95% CI -0·004 to 0·424] for T2 and a borderline effect of 0·216 SD [0·043 to 0·389] for T3) and lower stunting prevalence (-9·0% [95% CI -16·7 to -1·2] for T2 and -8·2% [-15·6 to -0·7] for T3); supplementing mothers conferred no additional benefit.LNS for children for a duration of 12 months only benefited growth when it began at an early age, suggesting the need to supplement infants at age 6 months in a very low-income context. The lack of effect of the early stimulation messages and home visits might be due to little take-up of behaviour-change messages and delivery challenges facing community health workers.Eunice Kennedy Shriver National Institutes of Child Health and Human Development, Strategic Impact Evaluation Fund, World Bank Innovation Grant, Early Learning Partnership Grant, World Bank Research Budget, Japan Nutrition Trust Fund, Power of Nutrition, and the National Nutrition Office of Madagascar.
Adenomatous polyposis coli (APC) protein causes hypersensitivity of mouse embryonic fibroblast cell lines to DNA-alkylating agent methylmethane sulfonate through base excision repair pathway
Authors: Chanakya Kundu, Ramesh Balusu, Aruna Jaiswal, Satya Narayan
Journal: Cancer Research (2007)

1961  The role of adenomatous polyposis coli (APC) has been implicated in various cellular functions including cell migration, cell-cell adhesion, cell cycle control, chromosomal segregation and apoptosis. Mutations in APC gene impair these functions and render cells susceptible to tumorigenesis. Recently, we discovered a novel role of APC in DNA base excision repair (BER) and showed that APC interacts with DNA polymerase β (pol-β) and flap endonuclease 1 (Fen-1) and interferes long-patch (LP)-BER by blocking strand-displacement synthesis. Many times, the chemotherapeutic drugs induce DNA-alkylation damage, which is primarily repaired by the BER pathway. Thus, the efficacy of such drugs can be increased by APC resulting in the blockage of LP-BER. In the present study, we tested this hypothesis by using isogenic wild-type and pol-β-knockout mouse embryonic fibroblast cell lines in which the APC gene was knocked down by the SiRNA technique and treated with methylmethane sulfonate (MMS). The MEF-APC+/+/polβ-/- cells were hypersensitive to MMS treatment compared to the MEF-APC+/+/polβ+/+ cells. However, once the APC gene was knocked down, these cells became more resistant to MMS treatment, suggesting that the MMS-induced hypersensitivity was associated with APC. We then determined whether the hypersensitivity of MEF-APC+/+/polβ-/- and MEF-APC+/+/polβ+/+ cell lines were due to decreased pol-β-independent and pol-β-dependent LP-BER pathways, respectively. The results of in vivo and in vitro LP-BER assays supported our findings. Further, APC-mediated hypersensitivity to MMS treatment was correlated with increased apoptosis of APC+/+/polβ-/- and MEF-APC+/+/polβ+/+ as compared to APC-/-/polβ-/- and MEF-APC-/-/polβ+/+ cells. These results suggest that an increased level of APC can increase the efficacy of DNA-alkylating drugs used as a curative therapy. Supported by NCI-NIH (CA-097031 and CA-100247) to SN.
Progress in diabetes care has not improved outcomes in US, study finds
Authors: Elisabeth Mahase
Journal: BMJ (2019)

Advances made in diabetes care over the past decade have not translated into improved outcomes among adults in the US, a study has found.1

Researchers from Massachusetts General Hospital looked at whether there had been any changes in achievement of diabetes treatment targets at the population level in the US from 2005 to 2016. They found no significant improvement in any of the individual targets over the period and that just one in four adults with diagnosed diabetes achieved all of their targets.

The paper, published in JAMA Internal Medicine , analysed cross sectional data from the National Health and Nutrition Examination Survey. It included …
Precision Therapy Targeting Signal Transduction Aberrant Pathways in Multiple Myeloma
Authors: Raahem Nayab Zafar, Atlantis Dawn Russ, Ahmad Iftikhar, Azka Latif, Vikas Kapoor, Faiza Hassan Warraich, Sami Ullah Warraich, Pavan Tenneti, Mirza Zeeshan Baig, Ali McBride, Faiz Anwer
Journal: Blood (2017)
The effect of the lymphovascular plugging metastasis pattern in extramammary Paget disease on identifying metastatic lesions using imaging tests: an autopsy case series
Authors: T. Maeda, K. Yoshino, K. Nagai, S. Oaku, M. Kato, A. Hiura, J. Uehara, Y. Fujisawa
Journal: British Journal of Dermatology (2019)
Molecular allelokaryotyping analysis of neuroblastoma using high-density SNP-genotyping microarrays
Authors: Junko Takita
Journal: Cancer Research (2007)

513  Neuroblastoma (NB) is one of the most common solid cancers in childhood. It shows highly variable clinical and biological features and is thought to consist of heterogeneous subgroups, each having a number of discrete genetic alterations. So, in order to identify these genetic changes and thus to get a better understanding of the pathogenesis of NB, we performed comprehensive analysis of copy number alterations as well as allelic imbalances in NB genomes using high-density SNP-genotyping microarrays (Affymetrx GeneChip 100K/500K arrays). In this platform, use of large numbers of SNP-specific probes showing linear hybridization kinetics allows not only for high-resolution copy number analysis, but also for accurate determination of the LOH regions. Unfortunately, however, the sensitivity of the currently available algorithm for LOH detection using SNP arrays may be greatly reduced when they are applied to primary tumor specimens frequently suffering from significant normal cell components. So to overcome this limitation, we developed a novel algorithm that enables accurate determination of allele-specific copy numbers as well as sensitive detection of LOH even in the face of up to 70-80% normal cell contamination. Analyis of 150 NB samples including 25 NB cell lines disclosed a number of previously unrecognized regions of significant LOH loci including 3q13.33-q29 (14%), 4p16.3-p15.32 (20%), 8q12.1-q24.3 (18%), 11p15.5-p15.4 (16%), 17p13.3-q12 (20%) and 18p11.32-q11.2 (20. Uniparental disomy (UPD) in several chromosomal loci such as 1p36.32-p22.3, 7q31.31-q36.3 and 12q21.1-q21.31 and high-grade amplifications of MYCN (60%) as well as other discrete amplicons in 2p25.2-p13.3 were also sensitively detected. Furthermore, common homozygous deletions such as 3q13.31 (8%), 5q34 (8%), 9p24.1-p23 (8%), 15q11.2 (10%) and 16p13.2-p13.3 (8%) were observed in several cases. These results indicated that copy number analysis using high-density SNP-genotyping microarrays is a powerful tool for genome-wide detection of genetic abnormalities in NB and expected to facilitate identification of novel genes relevant to development of NB.
Advanced cancer survival in a rural community: The impact of hospice services.
Authors: David Eric Cowall, Veera Holdai
Journal: Journal of Clinical Oncology (2013)

e20628 Background: The intensity of end-of-life (EOL) cancer care in a rural community has been previously reported (Cowall et al: J Oncol Pract 8: 40e-44e, 2012) using a random sample of all cancer deaths from Wicomico County, Maryland for calendar years 2004-2008. We now examine the impact of hospice services on survival in this same population. Methods: Significance (P-value) of diagnosis to death median survivals (MS) between different groups was calculated by log-rank analysis. Hazard ratios (HR) with 95% confidence intervals (CI) were obtained using Cox regression analysis. Results: 179 patients from our sample did not receive hospice services, and 211 were enrolled in hospice at some point during their illness. MS were 6.0 and 9.0 months respectively (P= 0.050, HR 1.222, CI 1.000-1.492). In the lung cancer subset, 54 patients did not receive hospice services and 78 were enrolled in hospice. MS were 5.0 and 7.0 months respectively (P=0.034, HR 1.468, CI 1.030-2.093). Other subsets were too small for analysis. Conclusions: Prolongedsurvival was significantly associated with hospice services in our sample, and that effect was more pronounced with lung cancer patients. The hospice effect on survival may reflect some combination of the following: hospice services result in better symptom management as well as counseling against toxic therapies at EOL and/or the bias of some patients against toxic treatments even before hospice enrollment.