tbuckley/cabot-search huggingface dataset:
FRI0028 Development and implementation of an educational video that instructs patients with rheumatoid arthritis for self-assessment of disease activity: methodology of the auto-das in middle eastern arab countries study
Authors: N. Ziade, G. Abi Karam, A. Daher, M. Abu Jbara, A. Ayko, E. Alam, T. Arayssi, H. Badsha, S. al Emadi, H. Halabi, G. Harifi, B. Khan, L. el Kibbi, M. al-Mashaleh, A.F. Masri, B. Masri, J. Menassa, M. Merashli, G. Merheb, J. Messaykeh, K. Mroue’, S. Saad, N. Salloum, I. Uthman, B. el-Zorkany
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Using a treatment target in rheumatoid arthritis (RA), such as DAS-28 and involving patients in their disease management can improve prognosis. <h3>Objectives</h3> To develop and implement an educational video that instructs patients with RA for self-assessment of disease activity using DAS-28. <h3>Methods</h3> <i>Step 1:Initiation.</i> Rheumatologists from some Middle Eastern Arab countries were invited to participate in this study. International experts and societies were contacted to access pre-existing educational material. <i>Step 2: Development.</i> Different material sources were synthetized and translated into Arabic and validated by the rheumatologists. The educational video was shot by a professional team with a real patient and a rheumatologist on set. <i>Step 3. Validation.</i> The final products (leaflets and video) were validated by the rheumatologists and tested with patients (figure 1). Obstacles were noted at the various study levels. <h3>Results</h3> 23 rheumatologists from 7 Middle Eastern Arab countries participated in the study. A one-page educational leaflet was developed in Arabic and English languages. An educational video presenting the treat-to-target concept and the basics of DAS performance was produced in Arabic language with English subtitles. Obstacles at the rheumatologist, patient, cultural and logistic levels were identified and the potential solutions were addressed by the study team. <h3>Conclusions</h3> Collaboration between several countries sharing the same language and similar cultural backgrounds was possible and able to produce an educational video aiming at the empowerment of RA patients for the self-assessment of their disease activity. The video will serve for future studies in the Arabic-speaking countries and will be available later for clinical use according to the rheumatologist’s clinical judgment. <h3>References</h3> <b>[1]</b> Smolenet al. Ann Rheum Dis2015;0:1–13. [2] Gossec, et al. Arthritis Rheumatol2016;68(suppl 10). [3] Studenic, et al. 2012;64(9):2814–23. www.nras.org.uk and www.das-score.nl <h3>Acknowledgements</h3> Professor Maxime Dougados, Paris. <h3>Disclosure of Interest</h3> None declared
AB0028 Activated stromal cells induce ccl20 release and t cell migration
Authors: G. Cafaro, E. Garcia-Melchor, M. Akbar, D.S. Gilchrist, S.M. Kitson, S. Siebert, N.L. Millar, I.B. McInnes
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Although the role of IL-23/Th17 axis in psoriatic arthritis (PsA) is well known<sup>1</sup>, little data is available on the contribution of stromal cells to this pathway<sup>2</sup>. Enthesitis is a common feature of PsA and it may represent the site of onset<sup>3,4</sup>, suggesting tendon stromal cells (tenocytes) may have an initiating role in Th17 driven pathogenesis. <h3>Objectives</h3> To assess the ability of stromal cells to produce CCL20, a chemokine able to recruit Th17 cells, and to induce T cell migration. <h3>Methods</h3> Healthy tenocytes cultured from hamstring tendons and fibroblast-like synoviocytes (FLS) from PsA patients were stimulated with human recombinant IL-1β (1 ng/ml) and IL-17A (1, 10 and 100 ng/ml). Expression of CCL20 transcript and protein were assessed by quantitative PCR and ELISA, respectively. T cell migration assays were performed with magnetically enriched CD3<sup>+</sup> cells from peripheral blood of PsA patients and healthy controls using a Transwell system. Following incubation with conditioned media from stimulated stromal cells, the migrated cells were harvested and analysed via light microscopy and flow cytometry. <h3>Results</h3> Both tenocytes and FLS were able to produce CCL20 following stimulation with IL-1β. Furthermore, the addition of IL-17A induced a synergistic effect with IL-1β. Following cytokine stimulation, diseased stromal cells produced greater levels of CCL20 compared to stimulated healthy tenocytes. In addition, conditioned media from stimulated tenocytes promoted T cell migration, compared with supernatants from unstimulated tenocytes. <h3>Conclusions</h3> We have shown that tendon and PsA synovium stromal cells are able to produce CCL20 and induce T cell recruitment, suggesting a role in the chemotaxis of Th17 cells. The positive feedback observed with IL1β and IL-17A suggests a close relationship between stromal cells and Th17 cells. <h3>References</h3> [1] Frleta M, Siebert S, McInnes IB. Curr. Rheumatol. Rep. 2014;16:414. [2] Millar NL, Murrell GAC, McInnes IB. Nat. Rev. Rheumatol. 2017;13:110–122. [3] Benjamin M, McGonagle D. Adv. Exp. Med. Biol. 2009;649:57–70. [4] Sherlock JP, et al. Nat. Med. 2012;18:1069–1076. <h3>Acknowledgements</h3> Giacomo Cafaro was supported by Partner Fellowship and EULAR Fellowship <h3>Disclosure of Interest</h3> None declared
Environmental Exposures and Depression: Biological Mechanisms and Epidemiological Evidence
Authors: Matilda van den Bosch, Andreas Meyer-Lindenberg
Journal: Annual Review of Public Health (2019)

Mental health and well-being are consistently influenced-directly or indirectly-by multiple environmental exposures. In this review, we have attempted to address some of the most common exposures of the biophysical environment, with a goal of demonstrating how those factors interact with central structures and functions of the brain and thus influence the neurobiology of depression. We emphasize biochemical mechanisms, observational evidence, and areas for future research. Finally, we include aspects of contextual environments-city living, nature, natural disasters, and climate change-and call for improved integration of environmental issues in public health science, policies, and activities. This integration is necessary for reducing the global pandemic of depression.
FRI0236 Associations between comorbidity and urate deposition in subjects with asymptomatic hyperuricemia: a pilot study
Authors: G. Kerr, S. Dowell, A. Wells, R. Haddad, P. DeMarco, J. Joseph, J. Ude, S. Hochberg, J. Huang, D. Nashel
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Hyperuricemia is common and along with comorbidities, is increasing in prevalence. Though often asymptomatic and hence, under diagnosed, it may be associated with subclinical urate deposition. Ultrasound (US) imaging can detect urate deposition in individuals with asymptomatic hyperuricemia (ASU). <h3>Objectives</h3> To evaluate the association of comorbidities with urate deposition via US in ASU. <h3>Methods</h3> ASU was defined as serum urate (sUA) &gt;6 mg/dl; sUA &lt;6 mg/dl served as controls. Demographic (age, gender, BMI), comorbidity (CM – [hypertension (HTN), hyperlipidemia (HLD), diabetes mellitus (DM), cardiovascular (CVD) and renal disease (CKD)], diuretic/aspirin use, dietary data (alcohol, red meat, seafood) were collected. Ultrasonography (US) of joints (knee/MTP), tendons (triceps, quadriceps/patella, Achilles) was performed via standard procedure, OMERACT parameters of urate deposition documented, and images read by an Expert ultrasonographer blinded to sUA category. Correlations between sUA levels and MSK urate deposition with comorbidities, medication and dietary risk factors were analysed by 2-stage multivariable logistic regression model with propensity score weighting. <h3>Results</h3> Of 95 predominantly non-Hispanic Blacks (mean age 59.7 years, BMI ~32 kg/m<sup>2</sup>), ASU subjects (n=71, median sUA=8.0) were older men, with more frequent HTN, CVD, CKD, alcohol ingestion versus controls. In multivariate analyses adjusting for demographic characteristics, BMI, CKD, and alcohol use were positively associated with sUA &gt;6 mg/dl; while HTN, CVD, and CKD were positively associated with sUA &gt;8 mg/dl. Adjusting for comorbidities, sUA &gt;8 mg/dl was significantly associated with urate deposition at knee (OR=3.20; p=0.03), quadriceps and Achilles tendons (OR=4.14; p&lt;0.01), OR=9.51; p&lt;0.01, respectively) but not at 1 st MTP (OR=2.14; p=0.06). A sUA &gt;6 mg/dl alone, however, did not predict urate deposition. <h3>Conclusions</h3> Presence of HTN, CVD and CKD are associated with higher levels of sUA and increases the risk of urate deposition in ASU patients. Identifying a subset of ASU patients that may benefit from urate lowering therapy requires further stratification and long term follow up for incident gouty arthritis in order to alter current urate lowering treatment guidelines. <h3>Disclosure of Interest</h3> G. Kerr Grant/research support from: Ardea, Grunenthal, Horizon, S. Dowell Grant/research support from: Horizon, A. Wells: None declared, R. Haddad: None declared, P. DeMarco: None declared, J. Joseph: None declared, J. Ude: None declared, S. Hochberg: None declared, J. Huang: None declared, D. Nashel: None declared
Alternative Donor Hematopoietic Stem Cell Transplantation for Sickle Cell Disease in Europe
Authors: Barbara Cappelli, Graziana Maria Scigliuolo, Fernanda Volt, Selim Corbacioglu, Josu de la Fuente, Nathalie Dhedin, Corinne Pondarré, Juergen Foell, Farah O' Boyle, Arjan Lankester, Elisabetta Calore, Stefania Varotto, Marco Zecca, Amal Al-Seraihy, Mahmoud Aljurf, Anders Fasth, Sonia Bonanomi, Maria Carmen Addari, Franco Locatelli, Alina Ferster, Veerle Labarque, Peter Bader, Belinda Pinto Simões, Karina Tozatto-Maio, Vanderson Rocha, Mathieu Kuentz, Hanadi Elayoubi, Annalisa Ruggeri, Francoise Bernaudin, Eliane Gluckman
Journal: Blood (2018)
Unplanned 30-Day Readmission and Predictors of Readmission in Patients with Neutropenic Fever : Insights from National Readmission Database
Authors: Supreet Kaur, Aparna Saha, Mohamed Tausif Siddiqui, Priti Poojary, Parita Ratnani, Sudarsan Kollimuttathuillam, Abhishek Kumar, Michael Maroules
Journal: Blood (2018)
AB1000 Association of serum uric acid level with bone mineral density and osteoporosis in postmenopausal women with rheumatoid arthritis
Authors: J.H. Koh, S.-G. Lee, H.-N. Lee, E. Kim, D.H. Sohn, Y. Kim, G.-T. Kim
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Previous studies have reported that higher serum uric acid (SUA) levels are associated with higher bone mineral density (BMD) in men and postmenopausal women, and lower risk of fragility fracture in men. However, whether this association is also present in patients with rheumatoid arthritis (RA) has not yet been investigated. <h3>Objectives</h3> To examine the association of SUA levels with BMD and osteoporosis in postmenopausal women with RA. <h3>Methods</h3> We retrospectively evaluated 447 postmenopausal female RA patients (mean age 61.1 years) who underwent measurement of L1–4, femoral neck, and total hip BMD using dual energy X-ray absorptiometry, in addition to SUA levels at a university rheumatology centre in South Korea between 2004 and 2017. Osteoporosis was defined as a T-score of ≤−2.5 according to the World Health Organisation classification. <h3>Results</h3> The median (interquartile range) SUV level was 4 (3.3–4.8) mg/dL. The mean (±SD) L1–4, femoral neck, and total hip BMD were 0.93±0.16 g/cm2, 0.75±0.12 g/cm2, and 0.81±0.12 g/cm2, respectively, and the frequencies of osteoporosis in the spine, hip, and either site were 25.6%, 15.9%, and 32.5%, respectively. SUA levels were positively correlated with L1–4 (ρ=0.102, p=0.032), femoral neck (ρ=0.123, p=0.01), and total hip BMD values (ρ=0.146, p=0.002) and body mass index (ρ=0.231, p&lt;0.001), and negatively correlated with glomerular filtration rate (ρ=−0.363, p&lt;0.001) in Spearman correlation analysis. In multivariable linear regression models adjusted for confounding factors, SUA levels showed a significant positive association with femoral neck BMD (β=0.0099, p=0.015) and total hip BMD (β=0.0118, p=0.01) but not with L1–4 BMD (β=0.0086, p=0.159) as shown in table 1. In addition, multivariable logistic analysis revealed that the third (OR=0.44, p=0.038) and fourth SUA quartiles (OR=0.37, p=0.021) were associated with lower risk of hip osteoporosis, as compared with the first SUA quartile. However, this association was not observed in lumbar spine osteoporosis. <h3>Conclusions</h3> Higher SUA levels were associated with a reduced risk of low BMD and osteoporosis at hip in postmenopausal women with RA, but no significant association between SUA levels and lumbar spine BMD was found. Our data suggests that uric acid may act as a protective factor against hip bone loss in RA patients. <h3>Disclosure of Interest</h3> None declared
Controlled release of corticosteroid with biodegradable nanoparticles for treating experimental autoimmune uveitis
Authors: Lixia Luo, Jin Yang, Yumin Oh, Matthew J. Hartsock, Shiyu Xia, Yoo-Chun Kim, Zheng Ding, Tuo Meng, Charles G. Eberhart, Laura M. Ensign, Jennifer E. Thorne, Walter J. Stark, Elia J. Duh, Qingguo Xu, Justin Hanes
Journal: Journal of Controlled Release (2019)
First-in-Human Study of the EZH1/2 Dual Inhibitor DS-3201b in Patients with Relapsed or Refractory Non-Hodgkin Lymphomas — Preliminary Results
Authors: Dai Maruyama, Kensei Tobinai, Shinichi Makita, Takashi Ishida, Shigeru Kusumoto, Kenji Ishitsuka, Makoto Yoshimitsu, Yoshitaka Imaizumi, Yasushi Sawayama, Shogo Takeuchi, Atae Utsunomiya, Kunihiro Tsukasaki, Sumiaki Fujitani, Kazushi Araki
Journal: Blood (2017)
The Burden of Relapsed/Refractory (R/R) Diffuse Large B-Cell Lymphoma (DLBCL): A Systematic Literature Review (SLR)
Authors: Georg Lenz, Sarah C. Rutherford, Andrew Davies, Pier Luigi Zinzani, Gilles Salles, Jens Hasskarl, Sandra Margunato-Debay, Filipe Rodrigues, Lisette Nientker, Janita Balradj, Cathelijne Alleman
Journal: Blood (2018)
THU0419 Association of inflammatory markers c-reactive protein and erythrocyte sedimentation ratewith pulmonary function tests and european scleroderma study group activity index (ESCSG-AI) in systemic sclerosis – associated interstitial lung disease in follow up study
Authors: O.B. Ovsyannikova, O. Koneva, L. Ananieva
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> inflammatory markers are very important to assess severity and activity of SSc-ILD, but it's role needs further investigation. <h3>Objectives</h3> to assess inflammatory markers of SSc such as hsCRP and ESR and compare with lung function test and EScSG-AI in the long-term follow up study. <h3>Methods</h3> It was a longitudinal study involving 77 pts with SSc-ILD (mean age was 46,2±13,4; 69% have limited subset of the disease; 93% were female). The mean duration of follow up was 58,9±11,4 months. Pts. were investigated with HRCT twice (at first visit and at the end of the study) and according the CT-changes were divided into 3 groups: the 1st group (16 pts) with improvement; 2nd group (39 pts) without any changes and 3rd group (22 pts) with worsening of fibrosis. Other data collected including biological results (high-sensitivity C-reactive protein (hsCRP) and erythrocyte sedimentation rate (ESR)), PFT (forced vital capacity (FVC,% of predicted) and diffusing capacity of the lung for carbon monoxide (DLCO,% of predicted), composite score (EScSG-AI). <h3>Results</h3> there were no significant differences between groups related to sex, frequency of diffuse form and duration disease. Mean levels of hsCRP and ESR didn't change significantly during the follow up. In all pts the mean levels of hsCRP and ESR correlated directly with each other at first visit and at the end of the study (R=0,45 and R=0,4 (p&lt;0,001) accordingly. We compared the mean levels of hsCRP and ESR with mean dates of FVC, DLCO and EScSG-AI score in first visit and the end of follow up. Mean levels of hsCRP inversely correlated with mean dates of DLCO at the first visit and at the end of the study (R=-0,39 and R=-0,42 (p&lt;0,05) accordingly); in groups 2 and 3 (R=-0,34 and R=-0,47 (p&lt;0,05) accordingly) at the end of the study; with mean dates of FVC in all pts and group 2 (R=-0,42 and R=0,47 (p&lt;0,05) accordingly) only at the end of the study; correlated directly with EScSG-AI score in all pts and groups 2,3 (R=0,58 (p&lt;0,0001), R=0,46 (p&lt;0,01) and R=0,77 (p&lt;0,001) accordingly) at the end of the study. While mean levels of ESR inversely correlated with mean dates of DLCO only in all pts and groups 1,2 (R=-0,43, R=-0,66 and R=-0,39 (p&lt;0,05) accordingly) at first visit; correlated directly with EScSG-AI score in all pts. (R=0309 (p&lt;0,01) at the end of the study. Mean levels of hsCRP inversely correlated with DLCO, FVC and directly correlated with EScSG-AI and these correlations were more evident than with mean levels of ESR. <h3>Conclusions</h3> In our group of pts. the hsCRP has proven to be an accurate reflection of disease severity especially in pts with progression of ILD. <h3>Disclosure of Interest</h3> None declared
AB1194 Are there new parameters to be considered in spectral doppler to evaluate the nail bed in psoriasis and psoriasis arthritis?
Authors: J.A. Mendonça, L.N. Pansani, M.B. Mimoto, E.C. Machado, A.C. Bazan
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Other spectral Doppler parameters can assess joint impairment caused by psoriatic arthritis and psoriasis<sup>1</sup>. <h3>Objectives</h3> To detect and compare Doppler velocimetric indexes changes in 3 groups of patients. <h3>Methods</h3> Thirty – eight patients were evaluated: 8 in the control group – healthy (52 nail beds); 15 in the psoriasis group (134 nail beds); and 15 in the group with psoriatic arthritis (147 nail beds). "CASPAR" criteria were used to classify the patients. The ultrasound (US) was performed in all patients using Esaote MyLab 50, with high resolution linear probe with a frequency of 18 mHz, it was positioned longitudinally to the nail bed. <h3>Results</h3> The psoriasis group of patients included 7 males (46.6%) and 8 females (53.4%); 66.6% were white, 33,4% black. Statistically significant: Mean age and SD of the psoriasis, psoriatic arthritis and control groups, respectively: 57.13±14.3 years; 54.66±10.6 years; 24.87±2.03 years (p&lt;0.05). A statistically significant difference was found in the <b>NAPSI</b> variable among all groups <b>(p&lt;0.05)</b>; in the variable <b>PASI</b>, a difference was only found in the control group <b>(p&lt;0.05)</b> (Kruskall-Wallis) (table 2); the <b>A</b> variable between the psoriasis group and control <b>(p&lt;0.001)</b>; between the psoriatic arthritis group and control <b>(p=0.001)</b>, the variable <b>T</b> between the psoriasis and psoriatic arthritis groups <b>(p=0.006)</b> and between the psoriasis and control groups <b>(p=0.001)</b> and the α variable between control and psoriasis groups <b>(p=0.017)</b> (table 1). <b>Spearman and Pearson correlations</b> between US variables per group, psoriasis, psoriatic arthritis and control were: <b>RIxPI</b> r=0.744 <b>(p&lt;0.001)</b>, <b>PD (power Doppler)xT</b> r=0.301 <b>(p&lt;0.001)</b>, <b>RIxPI</b> r=0.914 <b>(p&lt;0.001)</b>, <b>PIxA</b> r=0.46 <b>(p&lt;0.001); RIxPI</b> r=0.889 <b>(p&lt;0.001)</b>, <b>PDxT</b> r=0.490 <b>(p&lt;0.001)</b> respectively. <h3>Conclusions</h3> There are other parameters in spectral Doppler to be validated in order to characterise changes in nail beds. <h3>Reference</h3> [1] Mendonça JA. High Specificity of Spectral Nail Assessment in Psoriatic Arthritis Patients [abstract].Arthritis Rheumatol. 2015;67(suppl 10). <h3>Disclosure of Interest</h3> None declared
AB0596 The immune complexes of igg/igm bound to b-2-glycoprotein i are associated with livedo reticularis, thrombocytopenia and sicca in aps patients
Authors: D. Pérez, L. Stojanovich, L. Naranjo, N. Stanisavljevic, G. Bogdanovic, M. Serrano, A. Serrano
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Several manifestations strongly associated with APS have been excluded as classification criteria.<sup>1 2</sup> <h3>Objectives</h3> The aim of this study was to investigate correlation between circulating immune-complexes of IgG or IgM antibodies bound to B2GPI (B2G-CIC and B2M-CIC) and clinical manifestations in Serbian cohort of APS patients. <h3>Methods</h3> A total of 57 patients with APS were evaluated: 35 with PAPS and 22 patients with SAPS. Mean age was 47.6±1.6 years; 36 (63.2%) were women. All patients have met the 2006 revised Sydney criteria for APSQuantification of B2G-CIC and B2M-CIC levels was performed as previously, for detect B2G-CIC was used anti-human IgG HRP-conjugate and for B2M-CIC human IgM HRP- conjugate, both from INOVA (INOVA Diagnostics Inc., San Diego, CA, USA). <h3>Results</h3> In our cohort Serbian APS patients the prevalence of CIC was 19.29% (11/57); 8 patients with B2M-CIC and the remain 3 patients with B2G-CIC. Livedo reticularis was diagnosed with higher prevalence in patients with CIC compared with patients without CIC; 63.6% and 23.9%, respectively (OR: 5.57, p=0.01). In patients with CIC, thrombocytopenia and leukopenia were more prominent; 54.4% vs 17.4% (OR: 5.70, p=0.01) and 45.5% vs 13.0% (OR: 5.56, p=0.01), respectively. Ophthalmic sicca was more prevalent in patients with CIC; 54.4% vs 8.7% (OR: 12.6, p&lt;0.001). Although complement consumption was more frequent in patients with CIC (figure 1). Figure 1 Mean levels of C3 (A) and C4 (B) complement in groups. Mean levels of C3 (115.6±9.2 mg/dL and 140.9±4.3 mg/dL, group-1 and group-2 respectively) and mean levels of C4 (140.9±4.3 mg/dL and 30.8±1.6 mg/dL, group-1 and group-2, respectively). <h3>Conclusions</h3> B2G-CIC and B2M-CIC are strongly associated with clinical manifestations related to APS. Widening the APS spectrum is indispensable to better understand this syndrome. <h3>References</h3> [1] Stojanovich L, Kontic M, Djokovic A, Marisavljevic D, Ilijevski N, Stanisavljevic N, et al. Association between systemic non-criteria APS manifestations and antibody type and level: results from the Serbian national cohort study. Clin Exp Rheumatol. 2013 Mar-Apr;31(2):234–42. [2] Stojanovich L, Markovic O, Marisavljevic D, Elezovic I, Ilijevski N, Stanisavljevic N. Influence of antiphospholipid antibody levels and type on thrombotic manifestations: results from the Serbian National Cohort Study. Lupus. 2012Mar;21(3):338–45. <h3>Acknowledgements</h3> This work was supported by research grant number 175041, and TR 32040 for 2011–2018, issued by the Ministry of Science of the Republic of Serbia. <h3>Disclosure of Interest</h3> None declared