tbuckley/cabot-search huggingface dataset:
Prognostic Impact of Natural Killer Cell Count in Follicular Lymphoma and Diffuse Large B-cell Lymphoma Patients Treated with Immunochemotherapy
Authors: Magdalena Klanova, Mikkel Z. Oestergaard, Marek Trněný, Wolfgang Hiddemann, Robert Marcus, Laurie H. Sehn, Umberto Vitolo, Alexandra Bazeos, Valentin Goede, Harald Zeuner, Andrea Knapp, Deniz Sahin, Nathalie Spielewoy, Christopher R. Bolen, Andres Cardona, Christian Klein, Jeffrey M. Venstrom, Tina Nielsen, Günter Fingerle-Rowson
Journal: Clinical Cancer Research (2019)

Abstract Purpose: Natural killer (NK) cells are key effector cells for anti-CD20 monoclonal antibodies (mAb), such as obinutuzumab and rituximab. We assessed whether low pretreatment NK-cell count (NKCC) in peripheral blood or tumor tissue was associated with worse outcome in patients receiving antibody-based therapy. Patients and Methods: Baseline peripheral blood NKCC was assessed by flow cytometry (CD3−CD56+ and/or CD16+ cells) in 1,064 of 1,202 patients with follicular lymphoma treated with obinutuzumab or rituximab plus chemotherapy in the phase III GALLIUM trial (NCT01332968) and 1,287 of 1,418 patients with diffuse large B-cell lymphoma (DLBCL) treated with obinutuzumab or rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (G-CHOP or R-CHOP) in the phase III GOYA trial (NCT01287741). The prognostic value of tumor NK-cell gene expression, as assessed by whole-transcriptome gene expression using TruSeq RNA sequencing, was also analyzed. The association of baseline variables, such as treatment arm, was evaluated using multivariate Cox regression models using a stepwise approach. Results: In this exploratory analysis, low baseline peripheral blood NKCC was associated with shorter progression-free survival (PFS) in both follicular lymphoma [hazard ratio (HR), 1.48; 95% confidence interval (CI), 1.02–2.14; P = 0.04] and DLBCL (HR, 1.36; 95% CI, 1.01–1.83; P = 0.04), and overall survival in follicular lymphoma (HR, 2.20; 95% CI, 1.26–3.86; P = 0.0058). Low tumor NK-cell gene expression was associated with shorter PFS in G-CHOP–treated patients with DLBCL (HR, 1.95; 95% CI, 1.22–3.15; P &amp;lt; 0.01). Conclusions: These findings indicate that the number of NK cells in peripheral blood may affect the outcome of patients with B-cell non-Hodgkin lymphoma receiving anti-CD20–based immunochemotherapy.
15 minute interview: Kata tonic
Authors: Katariina Jarvi
Journal: BMJ (2005)

<b>Zoe Campbell</b> was born and raised in Nottingham. She took up karate at the age of 8. She is the current ladies world karate champion, having won numerous medals along the way. She obtained a first class biochemistry degree at Birmingham University before becoming a postgraduate student at Leicester-Warwick Medical School. She works as a house officer at Walsgrave Hospital, Coventry
Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum Period
Authors: Laura T. Dickens, Adam S. Cifu, Ronald N. Cohen
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Profile: Desert marathon madness
Authors: Karen Hebert
Journal: BMJ (2003)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Profile: Desert marathon madness Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Antinuclear antibodies mitotic patterns and their clinical associations
Authors: Juan F Betancur, José A Gómez-Puerta
Journal: Annals of the Rheumatic Diseases (2019)

Damoiseaux et al 1 recently reported an international consensus on antinuclear antibodies (ANA) based on 28 different patterns in order to harmonise the names and descriptions of the distinct HEp-2 indirect immunofluorescence assay (IIFA) patterns. The expert panel emphasised the clinical–serological relationships between immunofluorescence patterns and the corresponding test recommendations, rather than mechanistically testing antigen specificity (sometimes not commercially available), to provide the correct weight to the HEp2-IIFA pattern.

We appreciate the great effort made by these experts. However, we found that both in the original manuscript and the online supplementary material, limited mention was made of mitotic patterns and their possible clinical associations (with the exception of the …
A guide to medical etiquette: attire
Authors: David McAllister
Journal: BMJ (2000)

Like clowns, medical students really need a costume on to act the part of a doctor. I know that my communication skills improve tenfold when I am wearing my standard Marks and Spencer issue GP suede shoes.

However, many students don't get the costume right, and things just don't gel with patients. To remedy the situation, I have produced a guide on what to wear for the men and boys among you. I will be happy to …
“The Human Body” - the IMAX version
Authors: Navin Chohan
Journal: BMJ (2001)

The now ubiquitous Professor Robert Winston became a household commodity when he narrated The Human Body, the show that literally took viewers into parts that others could not reach. Where else could you see inside a full stomach or watch blood cells flowing in arteries? These were amazing images to medics and the viewing public alike.

Now the “incredible story of life” is back “on a screen the height of five double decker buses.” Yes, The Human Body has now made it to the massive IMAX format and, it has to be said, the result is quite impressive.



This release represents the end of a three year collaboration between the BBC, the Science Museum in London, …
Career focus: Applying for preregistration posts in Scotland
Authors: Amina Hussain
Journal: BMJ (2000)

Applying for preregistration posts in Scotland Amina Hussain reports on a new preregistration house officer allocation scheme that has just completed its first year of operation in Scotland. Traditionally, Scottish medical students were left to make their own arrangements for preregistration posts with the individual consultants they had come to know, or they were entered into regional matching schemes. Postgraduate departments often had little to do with the allocation of places and merely dispatched contracts once informed to do so by consultants.

There has always been a mismatch in the supply of and demand for medical graduates within the various regions of Scotland. Traditionally, this would result in the most popular posts in a region being filled by the local medical graduates who knew the consultants, while the least popular were filled by the “overflow” of students from regions where there weren't enough posts for the local graduates. Increasingly, panic stricken students were approaching consultants earlier and earlier in their academic careers to negotiate their preferred house officer posts. Consultants felt under strain at having to conduct so many exploratory discussions and to remember preliminary “deals” made as long ago as when students were only in their third year of medical school.



The problem was most acute in regions where there were not enough posts for local graduates, like the north east of Scotland. It has always been a “net exporter” of graduates, whereas the west coast has always been a “net importer.” Overall, there are enough house officer posts in Scotland to match the number of Scottish medical graduates. In some instances, however, medical graduates from other EU countries were filling remaining posts, usually in the west coast, before their Scottish counterparts even knew that the vacancies existed. This meant that some Scottish graduates, especially from the north east, …
Abstract 19312: Degeneration of Tunica Media in Acute Type-a Aortic Dissection From X-ray Phase-contrast Tomography
Authors: Koki Yokawa, Takuro Tsukube, Naoki Yagi, Masato Hoshino, Yutaka Nakashima, Kazunori Nakagawa, Yutaka Okita
Journal: Circulation (2017)

Objectives: Synchrotron radiation (SR)-based X-ray phase-contrast tomography (XPCT) has proven innovative modality for analysing 3D morphology and is useful for understanding the pathophysiology of...
Personal View: Hard Times
Authors: Navin Chohan
Journal: BMJ (2000)

At the end of 1997 I wound up in hospital with a rather serious illness and lost four weeks of teaching time. Then, in late November I was discharged only to be greeted with the news that my mother had developed end stage liver cancer.

I guess I had been kind of expectantly waiting for the moment when her condition would become terminal-my mother had developed breast cancer with complications some five years earlier, and even with more than two years' medical training, the diagnosis of end stage cancer still knocked me sideways. While I reeled from the double blow I had suffered I prepared for my return to academic work at college and, when the time came, I duly ploughed in with junior firms.

Over the following months my mother's health got worse and I was having to return home a lot to be with my family. By the beginning of March she was gravely ill and she was admitted to Hammersmith Hospital in London. I started travelling regularly across London, from Mile End in …
Cold snare piecemeal endoscopic mucosal resection of a very large duodenal adenoma
Authors: Siddharth B. Javia, Krishnavel Chathadi
Journal: Endoscopy (2019)

An 83-year-old woman was referred for the management of an incidentally found large duodenal polyp. The polyp was biopsied by the referring physician and was found to be a tubulovillous adenoma. The patient was scheduled for esophagogastroduodenoscopy with endoscopic mucosal resection (EMR).
Minerva: October 2002
Authors: S P Moule, J Heron, A H Goldstone, K M Ardeshna, J M R Goulding, E Phillips, N Johnson
Journal: BMJ (2002)

Entering the unresolved debate between alcohol consumption and bladder cancer, epidemiologists analysed data from an Italian case-control study and concluded that even in populations that drink a lot (in this case, wine) there is no significant association between the two. Its possible that confounding factors such as smoking, coffee drinking, and occupation (allowed for in this analysis) may have given rise to earlier inconsistent results ( Journal of Clinical Epidemiology 2002;55:637-41).

Summer sunburn seems to be the norm among American teenagers despite high sunscreen use. With 72% of teenagers experiencing at least one sunburn during the summer, public health campaigns should probably be paying more attention to getting the message across about hat wearing, protective clothing, and avoiding peak exposure times in the war against skin cancer ( Pediatrics 2002;110:27-35).

Minervas concentration usually wanes during the afternoon, and she has to turn to coffee. A Swedish team has discovered that a protein called DARPP-32 is critical to the action of caffeine. Low doses of caffeine …
Sarcopenia in Cirrhosis: Looking Beyond the Skeletal Muscle Loss to See the Systemic Disease
Authors: Rahima A. Bhanji, Aldo J. Montano‐Loza, Kymberly D. Watt
Journal: Hepatology (2019)

Sarcopenia is a common complication of cirrhosis and is defined as a progressive and generalized loss of skeletal muscle mass, strength, and function. Sarcopenia is associated with poor prognosis and increased mortality. How sarcopenia and muscle wasting relate to such poor outcomes requires looking beyond the overt muscle loss and at this entity as a systemic disease that affects muscles of vital organs including cardiac and respiratory muscles. This review explores the pathophysiological pathways and mechanisms that culminate in poor outcomes associated with sarcopenia. This provides a launching pad to identify potential targets for therapeutic intervention and optimization to improve patient outcomes.
Abstract 19293: Intra-Atrial Dyssynchrony Using Two Long-Axis Views to Quantify Tissue Remodeling in Patients With Atrial Fibrillation
Authors: Luisa C Ciuffo, Susumu Tao, Esra G Ipek, Tarek Zghaib, Muhammad Balouch, Joao Lima, Saman Nazarian, David Spragg, Joseph Marine, Ronald Berger, Hugh Calkins
Journal: Circulation (2017)

Introduction: Recent studies suggest that left atrial (LA) late gadolinium enhancement (LGE) can quantify the underlying tissue remodeling that harbors atrial fibrillation (AF). However, quantifica...
Surgical emergencies: Ear, nose, and throat emergencies
Authors: Nigel Beasley, Ashok Handa, Adam Jones, Kevin Turner
Journal: BMJ (2000)

Nigel Beasley , Ashok Handa , Adam Jones , and Kevin Turner explain how to deal with some ENT emergencies Loss of the airway is a frightening event for a patient, but the treatment options are relatively simple: unblock the airway or bypass the obstruction. The tricky part is recognising that a patient in severe respiratory distress has stridor and is not asthmatic. Two other conditions which can cause concern are severe persistent epistaxis, which may result in haemodynamic shock, and otalgia caused by the potentially serious intracranial complications of acute mastoiditis. Coloured scanning electron micrograph of a section through the human inner ear showing the spiral organ of Corti (DR G ORAN BREDBERG/SCIENCE PHOTO LIBRARY (MAGNIFICATION ×830 at 6×7cm)) The most obvious cause of upper airway obstruction is an inhaled foreign body. This can be dislodged by suddenly increasing the intrathoracic pressure and forcing the obstruction out like a cork from a bottle. This is done by using Heimlich's manoeuvre: stand behind the patient and grasp him or her around the upper abdomen; an upward thrust in the epigastric region may dislodge the offending article. Telling the difference between stridor and other causes of severe respiratory distress, including asthma and cardiac failure, is sometimes difficult. Obstruction of the upper airway results in an inspiratory or biphasic (inspiratory and expiratory) wheeze, whereas obstruction of the lower airway usually gives an expiratory wheeze. A patient with stridor will be making a great effort to breathe, have intercostal recession, tracheal tug (where the trachea seems to descend on inspiration), and little or no voice. #### Top tips #### Questions and answers
Medicine for finals - a study day
Authors: Jessica Westall
Journal: BMJ (2001)

Medical finals make everyone go a bit loopy-it's mostly harmless forgetfulness, an inability to hold conversations with non-medics, and either a total lack of sense of humour or finding medical references inappropriately funny. My affliction takes the form of a ravenous search for new sources of knowledge. I scour bookshops, looking for the medical textbook that is going to deliver me from the need to revise. I look for a book that contains secret medical knowledge censured from the textbooks I already own-the one book that is going to make it all seem clear.

I don't think I'm alone in this madness. As proved by a look round the lecture theatre on the study day “Medicine for finals,” there are more than 100 of us willing to part with more money than a big glossy textbook of medicine would cost, looking for an easy way to pass finals. At the beginning of the day, Dr Robert Clarke introduced himself as working part time in medical education, part time in general practice. “And yes,” I thought …
Scottish PRHO job allocation scheme fails applicants
Authors: Elspeth Isbister
Journal: BMJ (2002)

Final year medical students in Scotland are having to undergo unnecessary interviews for preregistration house officer (PRHO) jobs because of a failure in the Scottish PRHO allocation scheme.

The allocation scheme fills the majority of PRHO placements in Scotland. It uses a sophisticated computer system that allocates medical students to clinical units throughout Scotland, based on submitted preferences (1-3) of both the medical student applicant and the employing hospital units.

Students have been interviewed for posts in hospitals where the post had been made non-compliant and …
Global Snapshots: Cuba - a triumph of public health
Authors: Charlotte Chamberlain
Journal: BMJ (2003)

The James Bond film Die Another Day once again brought the eminence of Cuba's healthcare system into the spotlight. The prestigious fictional Cuban clinic featured in the film is depicted as executing groundbreaking gene therapy. Fiction, yes, but just how close is this to the truth? Cuba, many believe, has accomplished mission impossible. Despite the collapse of the Soviet Union, its prime financier, and the stringent restrictions of a US embargo, Cuba has triumphed: While Cuba's primary health care lacks equipment that British general practitioners take for …
Medical schools teach with humiliation and disrespect
Authors: Ahmed Kassem
Journal: BMJ (2004)

Medical students are subjected to humiliation and say that medicine is defined by competition rather than cooperation, a study in the BMJ has found (2004;329:770-3).

Heidi Lempp, senior qualitative researcher at Guy's, King's, and Thomas' Medical School, and Clive Seale, professor of sociology at Brunel University, interviewed 36 students in years one to five at an unnamed UK medical school.

The researches wanted to investigate how medical students are affected by the “hidden curriculum”--the “processes, pressures, and constraints which fall outside the formal curriculum, and which are often unarticulated or unexplored.”

Dr Lempp told Student BMJ , “I have noticed a clear and observable alteration in the attitudes and behaviours of medical students during the period of medical studies, changes that could not solely be explained by their personal maturity or academic content of the course.”

Two thirds of students (25) described the haphazard nature of teaching by clinical staff, who often disregarded the timetable. Twenty students indicated that unscheduled changes to teaching sessions were common and wasted time.

A third year student who participated in the study said, “Obviously the people who are teaching have another job--it's not their only job to teach you--but it's when you turn …
Identification of new promising germline variants in melanoma-prone patients
Authors: Felipe Fidalgo, Luciana Facure, Bruna Barros, Renan Valieris, Giovana Torrezan, Bianca de Sá, Amanda Nóbrega, Maria Isabel Achatz, João Duprat, Carla Rosenberg, Sandro Souza, Ana Krepischi, Dirce Maria Carraro
Journal: Clinical Cancer Research (2018)
The Elusive Magic Mullet. The Search for the Perfect Drug
Authors: Andrew Coulton
Journal: BMJ (2000)

I wonder, what sort of books do you like to read? Textbooks perhaps? Well, probably not. Or novels? Books to transport you into fiction land, removed from exams, hard work, and indeed, those textbooks.

As new drugs are forever being sought, John Mann has written an account of the discoveries of the past that have brought us to the pharmacological understanding of the present day. He narrates a chronology of significant breakthroughs in drug treatments, from the 16th century physician Paracelcus and his rather toxic treatments for …
The VIP (very important patient)
Authors: Liam P Scott
Journal: BMJ (2006)

My shoulder had been in agony for several days. Having recently started my revision for the impending clinical exams, I was aware that this was probably not a symptom I could ignore any longer. I slipped away from the ward where I had been examining patients and went downstairs to the emergency department. The most senior consultant saw me straight away.

I had barely begun to give him my history of sudden onset, pleuritic shoulder pain when he started listening to my chest, looking concerned. “Don't worry,” he said, sounding more sympathetic than I had ever …
Our attitudes towards patients
Authors: Teresa Pun
Journal: BMJ (2006)

The lecturer was trying to make a point: “The hand that writes the opiate writes the laxative. You may not think that constipation is such a big deal, but wait until you're on the wards next year guess who gets to do the digital disimpactions?” He left the podium amid laughter and groans. No one wanted to be the clerk stuck with that task.

The next lecturer was a nurse: “It's 10 times worse for the patient. I don't think you realise how painful and humiliating it is for a patient to have to go through something like that.” …
15 minute interview: CAPD of good hope
Authors: Olubimpe Ayeni
Journal: BMJ (2005)

Ashok Muzumdar, a semiretired specialist in rehabilitation medicine, has been gradually losing his vision over the past 20 years. Now he can see only outlines and can't appreciate detail. He founded the Canadian Association of Physicians with Disabilities (CAPD) in August 2000, and, at that time, it was the first association of its kind in the world to represent disabled doctors. The CAPD now has 72 members across Canada, with different physical and mental disabilities, and it is an affiliated society of the Canadian Medical Association (CMA).

After graduating from the University of Indore, India, in 1964, Ashok moved to England to train before finally settling in Canada. In 1985 he became the director and head of the department of physical medicine and rehabilitation at the Queen Elizabeth Hospital in Charlottetown, Prince Edward Island.

I had called a [telephone] number a couple of times but was told that it was out of service. When I asked my secretary to call, I was surprised that she was able to get through. I then realised that I had read …
Should medical students attempt to get consent?
Authors: Alexander S J Shaw
Journal: BMJ (2005)

BURGER/PHANIE/REX



Medical students often help out in theatre, but may not attempt to get a patient's consent first. This is a lawsuit waiting to happen, says Alexander S J Shaw

Medical law is difficult to understand without an appreciation and full understanding of the scale and importance of consent. Through spending time on the wards and in the theatres, medical students learn the need and legal importance of consent. I wonder whether we truly know the laws of consent, however. I would go as far as to ask whether all doctors do. The true breadth of the term “consent” is not fully appreciated and has become yet another automatism in the profession.

Many situations arise for which doctors and medical students are required to get consent. In clerking and performing procedures on conscious patients, it is obvious that we need to get informed consent. But at other times, consent is neglected. We learn and seem to appreciate that without consent any procedure or examination is deemed as battery and assault—a prosecutable offence. Consent therefore legitimises an otherwise unlawful act. But we still fail to extend the act of gaining consent …
Dynamic regulation of MTHFR MRNA expression and C677t genotype in individuals submitted to CABG: evidence for a role of homocysteine metabolism after coronary surgery
Authors: Alexandre C. Pereira, Ayumi A. Miyakawa, Neuza H. Lopes, Paulo R. Soares, Luís Alberto Oliveira Dallan, Whady Hueb, José Eduardo Krieger
Journal: Circulation (2004)