tbuckley/cabot-search huggingface dataset:
Abstract 12595: Variation in the Timing of Myocardial Infarctions After Hurricane Katrina: Eight Years After the Storm
Authors: Holly Gonzales, Kanwar Singh, Matthew Peters, Kevin Deandrade, Henry Quevedo, Hassan Baydoun, Muhammad Raja, Sudesh Srivastav, Anand Irimpen
Journal: Circulation (2015)

Introduction: The onset of acute myocardial infarction (AMI) has historically occurred with peaks on weekdays (especially Monday) and mornings, thought to be associated with stressful times of the day and week. AMI incidence increased in New Orleans following Hurricane Katrina with alterations in this chronobiology. The objective of this study is to determine the lasting impact of natural disasters on AMI chronobiology, which is currently unknown. Hypothesis: We hypothesized that the timing of AMI onset would return to pre-Katrina patterns given the amount of time lapsed since the storm. Methods: Single-center, retrospective, observational cohort analysis conducted at Tulane University Health Sciences Center (TUHSC) including symptomatic patients admitted for AMI with elevated troponin I. Exclusions were age &lt; 18 years, hospital transfers, in-hospital AMIs, and inadequate documentation of day and time of symptom onset. There were two cohorts: pre-Katrina, including patients admitted in the 6 years prior to storm landfall (8/29/99 - 8/28/05, n=299), and post-Katrina, including patients admitted in the 8 years after TUHSC re-opened after the storm (2/14/06 - 2/14/14, n=1479). Medical records were reviewed for symptom onset and various demographic, clinical and laboratory data. AMI incidence was defined as the number of AMI admissions divided by total hospital admissions. Results: Post-Katrina AMI incidence decreased on Mondays, weekdays, and mornings, and increased on nights and weekends (p&lt;0.0001, see table). The post-Katrina cohort had a significantly higher prevalence of smoking (53% vs 34%, p&lt;0.01), unemployment (39% vs 7%, p&lt;0.01) and lack of health insurance (25% vs 8%, p&lt;0.01) without significant differences in age or sex. Conclusions: After Hurricane Katrina, the expected morning, weekday, and Monday peaks of AMI onset were eliminated. Traditional patterns of AMI onset may be altered for prolonged periods of time following natural disasters.
Abstract MP74: Hnf1a Variant, Energy-reduced Diets, Weight Loss and Insulin Resistance: The Pounds Lost and Direct Trials
Authors: Tao Huang, Tiange Wang, Yan Zheng, Kerry Ivey, Ronen Durst, Dan Schwarzfuchs, Meir Stampfer, George Bray, Frank Sacks, Iris Shai, Lu Qi
Journal: Circulation (2016)

Background: Macronutrients regulate the gene expression of hepatic nuclear factor 1 alpha (HNF1A) which plays a key role in in the normal function of pancreatic beta cells and development of insulin resistance. Objective: We aimed to determine whether weight loss diets varying in macronutrients modulate the effect of HNF1A genetic variant on weight loss and improvement of insulin resistance. Methods: We analyzed the interaction between a diabetes-associated common variant in the HNF1A gene (rs7957197) and weight-loss diets on body weight and insulin resistance among 722 overweight/obese adults from a 2-year randomized weight-loss trial (POUNDS Lost). We then sought to validate the findings in an independent 2-year weight-loss trial (Dietary Intervention Randomized Controlled Trial; DIRECT), which involved 280 different overweight/obese adults. Results: In the POUNDS LOST, we found fat diet significantly modified the genetic effect of HNF1A such that greater decreases in body weight and waist were observed in participants with the T allele than others among high-fat diet group (P &lt;0.04 for both, P for interaction &lt;0.006, We observed borderline significant interactions for improvement of fasting insulin and insulin resistance (P for interaction=0.07 and 0.06, respectively). We found similar gene-fat interactions in the DIRECT. Conclusions: The consistent findings from two independent randomized intervention trials provide strong evidence that individuals with the HNF1A rs7957197 T allele may experience enhanced weight loss and improved insulin sensitivity as a result of hypocaloric, high-fat diets.
Clinical Parameters Correlate With Endoscopic Activity of Ulcerative Colitis: A Systematic Review
Authors: Sophie Restellini, Che-Yung Chao, Myriam Martel, Alan Barkun, Omar Kherad, Ernest Seidman, Gary Wild, Alain Bitton, Waqqas Afif, Talat Bessissow, Peter L. Lakatos
Journal: Clinical Gastroenterology and Hepatology (2018)
Solid Tumors in Post-Polycythemia Vera and Post-Essential Thrombocythemia Myelofibrosis: A Study on 2220 Patients
Authors: Barbara Mora, Elisa Rumi, Paola Guglielmelli, Daniela Barraco, Margherita Maffioli, Alessandro Rambaldi, Marianna Caramella, Rami S. Komrokji, Jason R. Gotlib, Jean-Jacques Kiladjian, Francisco Cervantes, Timothy Devos, Francesca Palandri, Valerio De Stefano, Marco Ruggeri, Richard T. Silver, Giulia Benevolo, Francesco Albano, Chiara Cavalloni, Daniela Pietra, Tiziano Barbui, Giada Rotunno, Mario Cazzola, Alessandro M. Vannucchi, Toni Giorgino, Francesco Passamonti
Journal: Blood (2018)
Simultaneous Targeting of CD19 and CD22: Phase I Study of AUTO3, a Bicistronic Chimeric Antigen Receptor (CAR) T-Cell Therapy, in Pediatric Patients with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia (r/r B-ALL): Amelia Study
Authors: Persis J Amrolia, Robert Wynn, Rachael Hough, Ajay Vora, Denise Bonney, Paul Veys, Kanchan Rao, Robert Chiesa, Muhammad Al-Hajj, Shaun P Cordoba, Shimobi Onuoha, Ekaterini Kotsopoulou, Nushmia Z Khokhar, Martin Pule, Vijay G R Peddareddigari
Journal: Blood (2018)
Abstract 19577: Diminazene Aceturate Inhibits Apoptotic Cell Death to Protect from Pulmonary Fibrosis and Associated Pulmonary Hypertension
Authors: Vinayak Shenoy, Yanfei Qi, Dipankar Gupta, Michael Katovich, Mohan Raizada
Journal: Circulation (2012)

INTRODUCTION: Studies have demonstrated that Angiotensin-converting enzyme2 (ACE2) plays a protective role against lung fibrosis. In this study, we evaluated the pharmacological actions of a recently identified synthetic activator of ACE2, Diminazene aceturate (DIZE) in the bleomycin model of pulmonary fibrosis (PF). METHODS: PF was induced by a single intratracheal instillation of bleomycin (Bleo, 5U/Kg) in 8 weeks old male Sprague-Dawley rats. Rats were randomized into three groups; Control, Bleo and Bleo+DIZE. DIZE treatment (15mg/Kg, sc) was commenced at the same time as bleomycin administration. After 2-weeks of bleomycin instillation, rats were instrumented to measure right ventricular systolic pressure (RVSP), followed by heart and lung excision to examine cardio-pulmonary remodeling and apoptosis. RESULTS: Bleomycin administration resulted in significant elevation of right ventricular systolic pressure (RVSP; Control: 26+1mmHg; Bleo: 41+2mmHg), signifying development of pulmonary hypertension. In addition, these animals exhibited maladaptive cardiac remodeling in terms of increased myocardial fibrosis (%Fibrosis; Control: 6+0.23; Bleo: 17+0.3) and right ventricular hypertrophy (RVH; Control: 0.26+0.007; Bleo: 0.40+0.03). Co-administration of DIZE significantly attenuated all these parameters (RVSP; 32+0.5mmHg; RVH; 0.30+0.01 and %Fibrosis; 7.2+0.6). A higher Ashcroft score was observed in bleomycin-challenged animals, signifying development of PF, which was prevented by DIZE treatment (Control: 1.2+0.09; Bleo: 6.5+0.06; Bleo+DIZE: 2.8+0.03). The protective effects of DIZE were associated with favorable modulation of the pulmonary renin angiotensin system and decreased pro-inflammatory cytokines. Furthermore, lung sections of bleomycin administered animals showed increased TUNEL staining for apoptosis, which was prevented by DIZE treatment (TUNEL positive index; Con: 0.03+0.005; Bleo: 0.2+0.04; Bleo+DIZE: 0.07+0.003). CONCLUSION: Our studies show that DIZE, an ACE2 activator attenuates bleomycin-induced lung fibrosis and associated cardio-pulmonary pathology, indicating a therapeutic potential of this drug in PF therapy .
Additive manufacturing technology for porous metal implant applications and triple minimal surface structures: A review
Authors: Li Yuan, Songlin Ding, Cuie Wen
Journal: Bioactive Materials (2018)

Recently, the fabrication methods of orthopedic implants and devices have been greatly developed. Additive manufacturing technology allows the production of complex structures with bio-mimicry features, and has the potential to overcome the limitations of conventional fabrication methods. This review explores open-cellular structural design for porous metal implant applications, in relation to the mechanical properties, biocompatibility, and biodegradability. Several types of additive manufacturing techniques including selective laser sintering, selective laser melting, and electron beam melting, are discussed for different applications. Additive manufacturing through powder bed fusion shows great potential for the fabrication of high-quality porous metal implants. However, the powder bed fusion technique still faces two major challenges: it is high cost and time-consuming. In addition, triply periodic minimal surface (TPMS) structures are also analyzed in this paper, targeting the design of metal implants with an enhanced biomorphic environment.
Detection of Relapse by Tumor Markers Versus Imaging in Children and Adolescents With Nongerminomatous Malignant Germ Cell Tumors: A Report From the Children’s Oncology Group
Authors: Adriana Fonseca, Caihong Xia, Armando J. Lorenzo, Mark Krailo, Thomas A. Olson, Farzana Pashankar, Marcio H. Malogolowkin, James F. Amatruda, Deborah F. Billmire, Carlos Rodriguez-Galindo, A. Lindsay Frazier, Furqan Shaikh
Journal: Journal of Clinical Oncology (2018)

To investigate relapse detection methods among children and adolescents with nongerminomatous malignant germ cell tumors (MGCTs) and to determine whether tumor markers alone might be sufficient for surveillance.We retrospectively reviewed all patients enrolled in a phase III, single-arm trial for low-risk and intermediate-risk MGCTs. The method used to detect relapse was assessed based on case report forms, tumor markers, imaging, and pathology reports. Relapses were classified into one of two categories on the basis of whether they were (1) detectable by tumor marker elevation or (2) not detectable by tumor markers.A total of 302 patients were enrolled, and 284 patients had complete data for review. Seven patients had normal tumor markers at initial diagnosis, and none experienced a relapse. At a median follow-up of 5.3 years, 48 patients (16.9%) had experienced a relapse. After central review, 47 of 48 relapses (98%) were detected by tumor marker elevation. Of the 47 patients, 16 (33.3%) had abnormal tumor markers with normal/unknown imaging, 31 patients (64.6%) had abnormal tumor markers with abnormal imaging, and one patient (2.1%) had abnormal imaging with unknown marker levels at relapse.Tumor marker elevation is a highly sensitive method of relapse surveillance, at least among children and adolescents with tumor marker elevation at initial diagnosis. Eliminating exposure to imaging with ionizing radiation may enhance the safety of relapse surveillance in patients treated for MGCT.
Cognitive Performance in First-Degree Relatives of Individuals With vs Without Major Depressive Disorder
Authors: Lynn E. MacKenzie, Rudolf Uher, Barbara Pavlova
Journal: JAMA Psychiatry (2018)

<h3>Importance</h3> Findings of cognitive impairment in major depressive disorder (MDD), including remitted MDD, raise the question whether impaired cognition is part of preexisting vulnerability rather than a consequence of MDD or its treatment. To our knowledge, no meta-analyses have been published on cognitive impairment in first-degree relatives of individuals with MDD. <h3>Objective</h3> To compare cognitive performance between individuals with and without family history of MDD. <h3>Data Sources</h3> Medline/PubMed, PsycINFO, and Embase using combinations of search terms for<i>depression</i>,<i>first-degree relatives</i>, and<i>cognition</i>from January 1, 1980, to July 15, 2018. <h3>Study Selection</h3> Original articles that reported data on cognition in first-degree relatives of individuals with MDD compared with controls with no family history of major mental illness. <h3>Data Extraction and Synthesis</h3> Means and SDs were extracted, and standardized mean differences (SMD) between relatives and controls were calculated for each measure of cognitive performance. The relative-control differences in overall cognition and in specific cognitive domains were synthesized in random-effects meta-analyses with robust variance estimation that allows including multiple correlated measures of cognition within each study. Heterogeneity was quantified with<i>τ</i><sup>2</sup>. Publication bias was assessed with funnel plots and Egger intercept. <h3>Main Outcomes and Measures</h3> Performance on cognitive tests. <h3>Results</h3> Across 284 measures of cognition in 54 nonoverlapping samples including 3246 relatives of people with MDD (mean age 15.38 years, 57.68% females) and 5222 controls (mean age 14.70 years, 55.93% females), relatives of people with MDD performed worse than controls across all measures of cognition (SMD = −0.19; 95% CI, −0.27 to −0.11;<i>P</i> &lt; .001). Domain-specific meta-analyses showed similar size of relative-control difference in most domains of cognition, including Full-Scale IQ (SMD = −0.19), verbal intelligence (SMD = −0.29), perceptual intelligence (SMD = −0.23), memory (SMD = −0.20), academic performance (SMD = −0.40), and language (SMD = −0.29). Study characteristics were not significantly associated with observed between-group differences. There was no evidence of publication bias. <h3>Conclusions and Relevance</h3> A general impairment in cognition is a feature of familial disposition for MDD. Cognition may contribute to early identification of risk for depression and may be examined as potential target for early intervention.
Exploring LAG-3 Expression in Multiple Myeloma Patients Following Autologous Stem Cell Transplant
Authors: Lucas Fabienne, Michael Pennell, Don M. Benson, Yvonne Efebera, Maria Chaudhry, Jennifer A. Woyach, Xiangnan Guan, Zhang Suohui, Christin E Burd, Ashley E. Rosko
Journal: Blood (2018)
Abstract 15819: Ventricular Arrhythmia Following Surgical vs Transcatheter Pulmonary Valve Replacement
Authors: Subeer K Wadia, Gentian Lluri, Jamil A Aboulhosn, Brian L Reemtsen, Hillel Laks, Reshma M Biniwale, Daniel S Levi, Morris Salem, Jeremy P Moore
Journal: Circulation (2017)

Transcatheter pulmonary valve replacement (TPVR) has emerged as a practical alternative to surgical pulmonary valve replacement (SPVR). We sought to compare the differences in ventricular arrhythmias (VAs) among congenital heart disease patients following TPVR or SPVR. This was a retrospective study of consecutive patients with repaired congenital heart disease undergoing TPVR or SPVR from 2010 to 2016 at UCLA Medical Center. The primary outcome was a composite of non-intraoperative VA, defined as symptomatic/recurrent non-sustained ventricular tachycardia (NSVT) requiring therapy, sustained ventricular tachycardia (VT), or ventricular fibrillation (VF). VA epochs were classified as 0-1 month (short-term), 1 month-12 months (mid-term), and ≥ 1 year (long-term). Three hundred and three patients (TPVR: n=172 and SPVR: n=131) were included (58% male, mean age 25.4 ± 14.7 years). Over a mean follow-up of 1.45 years, 16 (9%) VA events occurred in the TPVR group (11 NSVT and 5 sustained VT) vs 34 (26%) in the S...
Cognitive Impairment and Depression—Cause, Consequence, or Coincidence?
Authors: D. Chamith Halahakoon, Glyn Lewis, Jonathan P. Roiser
Journal: JAMA Psychiatry (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Adverse Events, Patterns of Tumor Lysis Syndrome Prophylaxis and Management, and Dosing Patterns in a Large Cohort of Venetoclax Treated CLL Patients in Community and Academic Settings
Authors: Lindsey E. Roeker, Christopher P. Fox, Toby A. Eyre, John N. Allan, Stephen J. Schuster, Chadi Nabhan, Brian T. Hill, Nirav N Shah, Frederick Lansigan, Maryam Yazdy, Nicole Lamanna, Bruce Cheson, Arun K Singavi, Catherine C. Coombs, Paul Barr, Alan P Skarbnik, Mazyar Shadman, Hande H. Tuncer, Chaitra S. Ujjani, Allison M. Winter, Joanna Rhodes, Colleen Dorsey, Hannah Morse, John M. Pagel, Annalynn M Williams, Ryan Jacobs, Andre Goy, Sivraj Muralikrishnan, Laurie Pearson, Andrea Sitlinger, Neil Bailey, Anna Schuh, Danielle M. Brander, Amy A Kirkwood, Anthony R Mato
Journal: Blood (2018)
Abstract 13037: Self-Care Questionnaire Detects More Brain Injury in Comparison to Cognitive Screener in Heart Failure
Authors: Mary A Woo, Bhaswati Roy, Gregg C Fonarow, Rajesh Kumar
Journal: Circulation (2016)

Introduction: Heart failure (HF) patients often have poor self-care (SC) and cognitive deficits. Both factors are closely related and require brain control of important skill sets. However, it is unclear if SC or cognition are linked to injury in different brain regions or if SC vs. cognition evaluation differs in the detection of brain damage amounts. Hypothesis: To determine if a measure of SC or cognition detects more brain injury in HF. Methods: Brain diffusion Tensor Imaging (DTI) data were collected from 10 HF (age 56.8±8.1 years; 8 male; LVEF 26.4±11.9% NYHA class II/III) using a 3 Tesla MRI scanner, Self-care was examined with the Self-Care of Heart Failure Inventory (SCHFI), and cognition with the Montreal Cognitive Assessment (MoCA) test. Using DTI data, mean diffusivity (MD; higher values=brain injury) maps were used to examine associations between SCHFI (maintenance and confidence subscales) and MoCA in HF subjects using partial correlation procedures (covariates: age and gender; uncorrected threshold p&lt;0.005). Results: Significant negative correlations between MD and confidence scores emerged in the prefrontal cortex. hippocampus, amygdala, anterior and posterior cingulate, anterior corpus callosum, mid and posterior thalamus, posterior insula, putamen, inferior temporal lobe, and cerebral vermis, and between MD and maintenance scores in the right putamen, external and internal capsule, and right inferior temporal lobe (Figure). Significant negative correlations were observed between MD and MoCA scores in the prefrontal cortex, occipital cortex, cerebellum, and mid-inferior temporal lobe (Figure). Conclusions: HF subjects show more wide-spread and significant correlations between regional MD values/brain injury and SCHFI scores compared to MoCA values. The findings suggest that damage in cognitive and decision-making control sites better correlate with SCHFI over MoCA scores.
Prevalence of Hepatitis C Virus Infection in US States and the District of Columbia, 2013 to 2016
Authors: Eli S. Rosenberg, Elizabeth M. Rosenthal, Eric W. Hall, Laurie Barker, Megan G. Hofmeister, Patrick S. Sullivan, Patricia Dietz, Jonathan Mermin, A. Blythe Ryerson
Journal: JAMA Network Open (2018)

IMPORTANCEInfection with hepatitis C virus (HCV) is a major cause of morbidity and mortality in the United States, and incidence has increased rapidly in recent years, likely owing to increased injection drug use.Current estimates of prevalence at the state level are needed to guide prevention and care efforts but are not available through existing disease surveillance systems.OBJECTIVE To estimate the prevalence of current HCV infection among adults in each US state and the District of Columbia during the years 2013 to 2016.DESIGN, SETTING, AND PARTICIPANTS This survey study used a statistical model to allocate nationally representative HCV prevalence from the National Health and Nutrition Examination Survey (NHANES) according to the spatial demographics and distributions of HCV mortality and narcotic overdose mortality in all National Vital Statistics System death records from 1999 to 2016.Additional literature review and analyses estimated state-level HCV infections among populations not included in the National Health and Nutrition Examination Survey sampling frame.EXPOSURES State, accounting for birth cohort, biological sex, race/ethnicity, federal poverty level, and year.MAIN OUTCOMES AND MEASURES State-level prevalence estimates of current HCV RNA.RESULTS In this study, the estimated national prevalence of HCV from 2013 to 2016 was 0.84% (95% CI, 0.75%-0.96%)among adults in the noninstitutionalized US population represented in the NHANES sampling frame, corresponding to 2 035 100 (95% CI, 1 803 600-2 318 000) persons with current infection; accounting for populations not included in NHANES, there were 231 600 additional persons with HCV, adjusting prevalence to 0.93%.Nine states contained 51.9% of all persons living with HCV infection (California [318 900], Texas [202 500], Florida [151 000], New York [116 000], Pennsylvania [93 900], Ohio [89 600], Michigan [69 100], Tennessee [69 100], and North Carolina[66 400]); 5 of these states were in Appalachia.Jurisdiction-level median (range) HCV RNA prevalence was 0.88% (0.45%-2.34%).Of 13 states in the western United States, 10 were above this median.Three of 10 states with the highest HCV prevalence were in Appalachia. CONCLUSIONS AND RELEVANCEUsing extensive national survey and vital statistics data from an 18-year period, this study found higher prevalence of HCV in the West and Appalachian states for 2013 to 2016 compared with other areas.These estimates can guide state prevention and treatment efforts.
Lower airway microbiota associates with inflammatory phenotype in severe preschool wheeze
Authors: Polly F.M. Robinson, Céline Pattaroni, James Cook, Lisa Gregory, Aldara Martin Alonso, Louise J. Fleming, Clare M. Lloyd, Andrew Bush, Benjamin J. Marsland, Sejal Saglani
Journal: Journal of Allergy and Clinical Immunology (2018)

Acute wheeze in preschool children accounts for more than 75% of pediatric health care attendances for wheeze/asthma in the United Kingdom.1 The high morbidity suggests current therapeutic strategies are failing. Preschool wheezers are heterogeneous; many have a disease course clinically distinct from that of childhood type 2–mediated allergic asthma.2 However, the pathologic mechanisms underpinning preschool wheeze are poorly understood. Treatment is currently determined by clinical phenotype.1 Episodic viral wheezers (EVWs) are predominantly prescribed intermittent therapies, and multiple-trigger wheezers (MTWs) are predominantly prescribed maintenance inhaled corticosteroids.
Royal colleges call for end to charges for overseas patients
Authors: Abi Rimmer
Journal: BMJ (2018)

Senior doctors have warned that charging overseas patients to use the NHS is acting as a barrier to care with implications for wider public health.

The Royal Colleges of Physicians, Paediatrics and Child Health, and Obstetricians and Gynaecologists and the Faculty of Public Health have called on the Department of Health and Social Care for England to suspend charges for overseas patients, pending a review of their effect.

In 2017 the government …