SAT0350 THE IMPACT OF FIBROMYALGIA ON SLEEP DISTURBANCE AND QUALITY OF LIFE IN PATIENTS WITH ANKYLOSING SPONDYLITIS
Authors: Iryna Shapoval, Mykola Stanislavchuk, Larysa Perebetiuk
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> Sleep disturbance is a very frequent symptom in patients with diseases associated with pain syndrome [1, 2]. Prevalence of sleep disorders in ankylosing spondylitis (AS) patients varies in a range of 35% to 90% [2]. One of the most common comorbid condition in patients with AS is fibromyalgia (FM), that can significantly worsen quality of life and sleep quality in patients with AS. <h3>Objectives</h3> The aim of this study was to evaluate the impact of FM comorbidity on sleep disturbance and quality of life in patients with AS. <h3>Methods</h3> One hundred and nineteen patients with AS according to modified New York criteria (mean age (M±SD) 42.23±11.5 years; 21 women and 98 men) were enrolled in the study. FM was diagnosed based on the 1990 American College of Rheumatology classification criteria. All patients were asked to complete self-report questionnaires, including the Pittsburgh Sleep Quality Index (PSQI) and Ankylosing Spondylitis Quality of Life Questionnaire (ASQoL) to assess sleep disturbance and quality of life. <h3>Results</h3> Of the AS patients, 23 (19.3%) met the criteria for FM. The patients were divided into two groups in terms of having or not having FM. Groups were representative for age and disease duration. Patients with AS and concomitant FM showed significantly increased frequency of sleep disturbance according to the PSQI. Only 26 patients with AS (27%) scored &lt;5 and indicated as "good sleepers", whereas all patients with AS and concomitant FM has poor sleep quality. In group with AS patients mean scores (M±SD) of PSQI were 7.52±3.96 and in group with AS+FM - 11.04±3.5 (<i>P</i>&lt; 0,01). Table 1 shows detailed information on the sleep quality of patients with and without FM. In general, for each of the component scores, patients with AS scored lower than patients with AS+FM, with statistically significantly less severe sleep problems on all domains except for use of sleep medication. Patients with AS and concomitant FM showed poorer quality of life according to ASQoL compared to patients with alone AS (13.8±2.35 vs. 8.6±4.01; p&lt; 0,01). <h3>Conclusion</h3> Sleep disturbance is a frequent condition in patients with AS. Our study results demonstrate the significant impact of FM comorbidity on sleep disturbance and quality of life in patients with AS. <h3>References</h3> [1] Bigatti, S. M., Hernandez, A. M., Cronan, T. A., &amp; Rand, K. L. (2008). Sleep disturbances in fibromyalgia syndrome: relationship to pain and depression. Arthritis Care &amp; Research: Official Journal of the American College of Rheumatology, 59(7), 961-967. [2] Leverment, S., Clarke, E., Wadeley, A. et al. (2017) Prevalence and factors associated with disturbed sleep in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis: a systematic review Rheumatol Int, 37: 257 https://doi.org/10.1007/s00296-016-3589-x <h3>Disclosure of Interests</h3> Iryna Shapoval: None declared, Mykola Stanislavchuk Grant/research support from: AstraZeneca, Celltrion, Galapagos, Genentech, GlaxoSmithKline, Human Genome, Lilly, MedImmune, Pfizer, Roche and UCB, Larysa Perebetiuk: None declared