tbuckley/cabot-search huggingface dataset:
More doctors need to train as expert witnesses, says MPS
Authors: Clare Dyer
Journal: BMJ (2019)

NHS employers should make it easier for doctors to be relieved of clinical duties to act as expert witnesses in court and at medical practitioners tribunal hearings, a leading doctors’ defence body has urged.

This could include modifying employment contracts to give the expert witness role more prominence and to provide greater certainty for doctors wishing to undertake the role, argued the UK Medical Protection Society.

The MPS said that expert evidence as to the expected standard of care could be pivotal …
New Drugs in Multiple Myeloma
Authors: Chutima Kunacheewa, Robert Z. Orlowski
Journal: Annual Review of Medicine (2019)

Multiple myeloma is diagnosed in over 100,000 patients each year worldwide, has an increasing incidence and prevalence in many regions, and follows a relapsing course, making it a significant and growing healthcare challenge. Recent basic, translational, and clinical studies have expanded our therapeutic armamentarium, which now consists of alkylating agents, corticosteroids, deacetylase inhibitors, immunomodulatory agents, monoclonal antibodies, and proteasome inhibitors. New drugs in these categories, and additional agents, including both small and large molecules, as well as cellular therapies, are under development that promise to further expand our capabilities and bring us closer to the cure of this plasma cell dyscrasia.
Transcriptomics Associates Molecular Features with 18F-Fluorocholine PET/CT Imaging Phenotype and Its Potential Relationship to Survival in Hepatocellular Carcinoma
Authors: Sandi A. Kwee, Maarit Tiirikainen, Miles M. Sato, Jared D. Acoba, Runmin Wei, Wei Jia, Loic Le Marchand, Linda L. Wong
Journal: Cancer Research (2019)

Abstract Studies involving transcriptomics have revealed multiple molecular subtypes of hepatocellular carcinoma (HCC). Positron emission tomography/computed tomography (PET/CT) has also identified distinct molecular imaging subtypes, including those with increased and decreased choline metabolism as measured by the tissue uptake of the radiopharmaceutical 18F-fluorocholine. Gene signatures reflecting the molecular heterogeneity of HCC may identify the biological and clinical significance of these imaging subtypes. In this study, 41 patients underwent 18F-fluorocholine PET/CT, followed by tumor resection and gene expression profiling. Over- and underexpressed components of previously published gene signatures were evaluated for enrichment between tumors with high and low 18F-fluorocholine uptake using gene set analysis. Significant gene sets were enumerated by FDR based on phenotype permutation. Associations with overall survival were analyzed by univariate and multivariate proportional hazards regression. Ten gene sets related to HCC were significantly associated with high tumor 18F-fluorocholine uptake at FDR q &amp;lt; 0.05, including those from three different clinical molecular classification systems and two prognostic signatures for HCC that showed predictive value in the study cohort. Tumor avidity for 18F-fluorocholine was associated with favorable characteristics based on these signatures with lower mortality based on survival analysis (HR 0.36; 95% confidence interval, 0.14–0.95). Tumors demonstrating high 18F-fluorocholine uptake were also enriched for genes involved in oxidative phosphorylation, fatty acid metabolism, peroxisome, bile acid metabolism, xenobiotic metabolism, and adipogenesis. These results provide a pathobiological framework to further evaluate 18F-fluorocholine PET/CT as a molecular and prognostic classifier in HCC. Significance: A pathobiological framework for HCC brings together multiple prognostically relevant gene signatures via convergence with 18F-fluorocholine PET/CT imaging phenotype.
A combined immunodeficiency with severe infections, inflammation, and allergy caused by ARPC1B deficiency
Authors: Stefano Volpi, Maria Pia Cicalese, Paul Tuijnenburg, Anton T.J. Tool, Eloy Cuadrado, Marwan Abu-Halaweh, Hamid Ahanchian, Raed Alzyoud, Zeynep Coban Akdemir, Federica Barzaghi, Alexander Blank, Bertrand Boisson, Cristina Bottino, Immacolata Brigida, Roberta Caorsi, Jean-Laurent Casanova, Sabrina Chiesa, Ivan Kingyue Chinn, Gregor Dückers, Anselm Enders, Hans Christian Erichsen, Lisa R. Forbes, Tomasz Gambin, Marco Gattorno, Ehsan Ghayoor Karimiani, Silvia Giliani, Michael S. Gold, Eva-Maria Jacobsen, Machiel H. Jansen, Jovanka R. King, Ronald M. Laxer, James R. Lupski, Emily Mace, Stefania Marcenaro, Reza Maroofian, Alexander B. Meijer, Tim Niehues, Luigi D. Notarangelo, Jordan Orange, Ulrich Pannicke, Chris Pearson, Paolo Picco, Patrick J. Quinn, Ansgar Schulz, Filiz Seeborg, Asbjørg Stray-Pedersen, Hasan Tawamie, Ester M.M. van Leeuwen, Alessandro Aiuti, Rae Yeung, Klaus Schwarz, Taco W. Kuijpers
Journal: Journal of Allergy and Clinical Immunology (2019)
Long-Term Durability of Transcatheter Aortic Valve Prostheses
Authors: Daniel J. Blackman, Smriti Saraf, Philip A. MacCarthy, Aung Myat, Simon G. Anderson, Christopher J. Malkin, Michael S. Cunnington, Kathryn Somers, Paul Brennan, Ganesh Manoharan, Jessica Parker, Omar Aldalati, Stephen J. Brecker, Cameron Dowling, Stephen P. Hoole, Stephen Dorman, Michael Mullen, Simon Kennon, Melanie Jerrum, Pavan Chandrala, David H. Roberts, Justin Tay, Sagar N. Doshi, Peter F. Ludman, Timothy A. Fairbairn, Joanne Crowe, Richard D. Levy, Adrian P. Banning, Neil Ruparelia, Mark S. Spence, David Hildick-Smith
Journal: Journal of the American College of Cardiology (2019)
Prognostic factor analysis in third-line chemotherapy for elderly patients with metastatic gastric cancer.
Authors: Hiroko Hasegawa, Tetsuya Iwasaki, Akio Ishihara, Yuko Sakakibara, Tomohumi Akasaka, Shoichi Nakazuru, Hisashi Ishida, Motohiro Hirao, Eiji Mita
Journal: Journal of Clinical Oncology (2019)

82 Background: Recently, the proportion of elderly patients (pts) with metastatic gastric cancer (mGC) has increased in Japan. Survival benefits of salvage treatment after second-line chemotherapy (CTX) for mGC were shown in several prospective studies. However, the role of salvage treatment in elderly pts remains controversial. Methods: We reviewed 185 pts with mGC who received palliative CTX aged ≥ 70 years at our institution between April 2007 and March 2018. Eligibility criteria were as follows: PS 0-2, refractory to first-line and second-line CTX. The purpose of this study was to evaluate the clinicopathologic factors that affected overall survival for elderly pts with mGC, univariate and multivariate analyses were performed on the baseline factors at the beginning of third-line CTX. Results: Of all, 71 pts were eligible. Median age was 75 years (71-85). Median progression-free survival (PFS) and overall survival (OS) for third-line CTX were 3.2 and 7.5 months, respectively and an overall response rate and disease control rate were 4.2% and 43.7%, respectively. In univariate analysis, the following four factors were identified to have prognostic significance: performance status (PS) (ECOG 0–1 or 2), serum albumin level (&lt; 3.5 or ≥ 3.5 g/dl), serum LDH level (≤ 240 or &gt; 240 IU/l), PFS under second-line CTX (&lt; 3 or ≥ 3 months). Multivariate analysis found three prognostic factors affecting poor survival following third-line CTX: PS of 2 (hazard ratio (HR) 8.89, 95% confidence interval (CI) 3.99–20.2; P = 0.001), serum LDH level &gt; 240 IU/l (HR 2.75, 95% CI 1.48–5.05; P = 0.002) and median PFS under second-line CTX of &lt; 3 months (HR 1.89, 95% CI 1.01–3.43; P = 0.045). A prognostic index was constructed, dividing pts into low- (0 factor), intermediate- (1-2 risk factors), or high- (3 risk factors) risk groups. Median OS for each group were 12.6, 6.0 and 3.0 months, respectively ( P &lt; 0.001). Conclusions: This analysis suggests that some clinicopathologic factors might be helpful in identifying the subgroup of elderly pts most likely to benefit from third-line CTX for metastatic gastric cancer.
Racial Differences in Sudden Cardiac Death
Authors: Di Zhao, Wendy S. Post, Elena Blasco-Colmenares, Alan Cheng, Yiyi Zhang, Rajat Deo, Roberto Pastor-Barriuso, Erin D. Michos, Nona Sotoodehnia, Eliseo Guallar
Journal: Circulation (2019)

Background: Blacks have a higher incidence of out-of-hospital sudden cardiac death (SCD) in comparison with whites. However, the racial differences in the cumulative risk of SCD and the reasons for these differences have not been assessed in large-scale community-based cohorts. The objective of this study is to compare the lifetime cumulative risk of SCD among blacks and whites, and to evaluate the risk factors that may explain racial differences in SCD risk in the general population. Methods: This is a cohort study of 3832 blacks and 11 237 whites participating in the Atherosclerosis Risk in Communities Study (ARIC). Race was self-reported. SCD was defined as a sudden pulseless condition from a cardiac cause in a previously stable individual, and SCD cases were adjudicated by an expert committee. Cumulative incidence was computed using competing risk models. Potential mediators included demographic and socioeconomic factors, cardiovascular risk factors, presence of coronary heart disease, and electrocardiographic parameters as time-varying factors. Results: The mean (SD) age was 53.6 (5.8) years for blacks and 54.4 (5.7) years for whites. During 27.4 years of follow-up, 215 blacks and 332 whites experienced SCD. The lifetime cumulative incidence of SCD at age 85 years was 9.6, 6.6, 6.5, and 2.3% for black men, black women, white men, and white women, respectively. The sex-adjusted hazard ratio for SCD comparing blacks with whites was 2.12 (95% CI, 1.79–2.51). The association was attenuated but still statistically significant in fully adjusted models (hazard ratio, 1.38; 95% CI, 1.11–1.71). In mediation analysis, known factors explained 65.3% (95% CI 37.9–92.8%) of the excess risk of SCD in blacks in comparison with whites. The single most important factor explaining this difference was income (50.5%), followed by education (19.1%), hypertension (22.1%), and diabetes mellitus (19.6%). Racial differences were evident in both genders but stronger in women than in men. Conclusions: Blacks had a much higher risk for SCD in comparison with whites, particularly among women. Income, education, and traditional risk factors explained ≈65% of the race difference in SCD. The high burden of SCD and the racial–gender disparities observed in our study represent a major public health and clinical problem.
Evidence for Epitope-Specific T Cell Responses in HIV-Associated Non Neoplastic Lymphadenopathy: High-Throughput Immunogenetic Evidence
Authors: Katerina Gemenetzi, Evangelia Stalika, Andreas Agathangelidis, Fotis Psomopoulos, Elisavet Vlachonikola, Chrysi Galigalidou, Symeon Metallidis, Triantafylia Koletsa, Kostas Stamatopoulos, Maria Papaioannou, Anastasia Hadzidimitriou
Journal: Blood (2018)
Genome-Scale CRISPR Screens Identify Essential Genes for Sensitivity to Natural Killer Cells in Hematological Malignancies
Authors: Olli Dufva, Jay Klievink, Khalid Saeed, Matti Kankainen, Mette Ilander, Tiina Hannunen, Sonja Lagström, Pekka Ellonen, Dean Anthony Lee, Satu Mustjoki
Journal: Blood (2018)
Annals Graphic Medicine - Dr. Mom: Doing It All
Authors: Grace E. Farris
Journal: Annals of Internal Medicine (2019)

Web Exclusives5 February 2019Annals Graphic Medicine - Dr. Mom: Doing It AllFREEGrace E. Farris, MDGrace E. Farris, MDMount Sinai School of Medicine, New York, New York (G.E.F.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/G18-0042 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Download figure Download PowerPoint Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: Mount Sinai School of Medicine, New York, New York (G.E.F.)Disclosures: The author has disclosed no conflicts of interest. The form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=G18-0042.Author/Illustrator Information: Grace E. Farris, MD, is an assistant professor of medicine at Icahn School of Medicine at Mount Sinai and chief of hospital medicine at Mount Sinai West hospital in New York, New York. You can view her work at her Web site: www.farrisgrace.com.About Dr. Mom: Dr. Mom explores the challenges and ups and downs of juggling life as a hospitalist and mother. The feature appears monthly in Annals Graphic Medicine at Annals.org. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAnnals Graphic Medicine: Introducing “Dr. Mom” and “Progress Notes”Annals Graphic Medicine: Introducing “Dr. Mom” and “Progress Notes” Metrics 5 February 2019Volume 170, Issue 3Page: W41-W42KeywordsConflicts of interestDisclosureHospital medicineHospitalists ePublished: 5 February 2019 Issue Published: 5 February 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Automated Pixel-Wise Quantitative Myocardial Perfusion Mapping by CMR to Detect Obstructive Coronary Artery Disease and Coronary Microvascular Dysfunction
Authors: Tushar Kotecha, Ana Martinez-Naharro, Michele Boldrini, Daniel Knight, Philip Hawkins, Sundeep Kalra, Deven Patel, Gerry Coghlan, James Moon, Sven Plein, Tim Lockie, Roby Rakhit, Niket Patel, Hui Xue, Peter Kellman, Marianna Fontana
Journal: JACC. Cardiovascular imaging (2019)
Robotic-assisted transanal repair of rectourethral fistula
Authors: Shih-I Tseng, Ching-Wen Huang, Tsung-Yi Huang
Journal: Endoscopy (2019)

Rectourethral fistulas represent an uncommon but severe complication of pelvic surgery, especially after radical prostatectomy, radiation therapy, and accidental intraoperative rectal injury. These fistulas usually present large (> 2 cm), complex, fibrotic tissue, and they are difficult to treat with conservative treatment [1]. Here, we present a new operative technique to successfully treat a patient with rectourethral fistula ([Video 1]).
Donor T Cell Independent Mechanism Is Critical for Mediating Steroid Refractory Gvhd in Murine Models
Authors: Tomomi Toubai, Corrine Rossi, Isao Tawara, Chen Liu, Cynthia Zajac, Katherine Oravecz-Wilson, Dan Peltier, Yaping Sun, Hideaki Fujiwara, Mary Mansour Riwes, Israel Henig, Stephanie Kim, Masahiro Suto, Kenichi Ishizawa, Pavan Reddy
Journal: Blood (2018)
Prognostic Utility of Oxygen-Sensitive Cardiac Magnetic Resonance Imaging in Diabetic and Nondiabetic Chronic Kidney Disease Patients With No Known Coronary Artery Disease
Authors: Ranjit Shah, Susie Parnham, Zach Liang, Rebecca Perry, Craig Bradbrook, Emma Smith, Randall Faull, Richard J. Woodman, Gaetano Nucifora, Jonathan M. Gleadle, Joseph B. Selvanayagam
Journal: JACC. Cardiovascular imaging (2019)
Where do Eritrean migrants get infected with malaria? The importance of considering the migration route
Authors: Philippe Gautret, Martin P Grobusch, Patricia Schlagenhauf
Journal: Eurosurveillance (2019)

Preview this article: Where do Eritrean migrants get infected with malaria? The importance of considering the migration route, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/24/6/eurosurv-24-6-7-1.gif
Impact of Myeloablative Total Body Irradiation Versus Chemotherapy on Late Effects and Survival Among Adolescent and Young Adult Survivors of Hematopoietic Cell Transplantation for Acute Leukemia: A Center for International Blood and Marrow Transplant Research (CIBMTR) Analysis
Authors: Catherine J. Lee, Soyoung Kim, Heather R. Tecca, Ruta Brazauskas, Minoo Battiwalla, David K. Buchbinder, Mary E. D. Flowers, Rachel Phelan, Bronwen E. Shaw, Lori S Muffly
Journal: Blood (2018)
Preliminary Safety and Efficacy Results with an Intermittent Schedule of the PI3kδ Inhibitor ME-401 Alone or in Combination with Rituximab for B-Cell Malignancies
Authors: Andrew D. Zelenetz, Jacob D. Soumerai, Deepa Jagadeesh, Nishitha Reddy, Anastasios Stathis, Adam S. Asch, Huda S. Salman, Vaishalee P. Kenkre, Haresh Jhangiani, Alexia Iasonos, Patel Krish, Richard G Ghalie, John M. Pagel
Journal: Blood (2018)
The developmental stage of the hematopoietic niche regulates lineage in <i>MLL-</i>rearranged leukemia
Authors: R. Grant Rowe, Edroaldo Lummertz da Rocha, Patricia Sousa, Pavlos Missios, Michael Morse, William Marion, Alena Yermalovich, Jessica Barragan, Ronald Mathieu, Deepak Kumar Jha, Mark D. Fleming, Trista E. North, George Q. Daley
Journal: The Journal of Experimental Medicine (2019)

Leukemia phenotypes vary with age of onset. Delineating mechanisms of age specificity in leukemia could improve disease models and uncover new therapeutic approaches. Here, we used heterochronic transplantation of leukemia driven by MLL/KMT2A translocations to investigate the contribution of the age of the hematopoietic microenvironment to age-specific leukemia phenotypes. When driven by MLL-AF9, leukemia cells in the adult microenvironment sustained a myeloid phenotype, whereas the neonatal microenvironment supported genesis of mixed early B cell/myeloid leukemia. In MLL-ENL leukemia, the neonatal microenvironment potentiated B-lymphoid differentiation compared with the adult. Ccl5 elaborated from adult marrow stroma inhibited B-lymphoid differentiation of leukemia cells, illuminating a mechanism of age-specific lineage commitment. Our study illustrates the contribution of the developmental stage of the hematopoietic microenvironment in defining the age specificity of leukemia.
Nasal Periostin Levels and Acute Symptoms in Asthmatics during Viral-induced Exacerbations
Authors: Sarah Pham, Olga Hardin, Darrell L. Dinwiddie, Sudeepa Bhattacharyya, Ashley Stoner, John C. Kincaid, Catherine Kirkpatrick, Claire Putt, Joshua L. Kennedy
Journal: Journal of Allergy and Clinical Immunology (2019)
A Novel Anti-IgM/HLA-DR Bispecific Antibody for Treatment of Refractory B Cell Malignancies
Authors: Takahiro Ohashi, Hitoshi Miyashita, Yuko Nagata, Satoko Tatebe, Hayuma Otsuka, Hirokazu Suzuki, Tetsuo Sasaki, Jumpei Enami, Yasukatsu Tsukada, Keiko Fukushima
Journal: Blood (2018)
Comparative Effectiveness of Busulfan/Cyclophosphamide Versus Busulfan/Fludarabine Myeloablative Conditioning for Allogeneic Hematopoietic Cell Transplantation in Acute Myeloid Leukemia
Authors: Sagar S. Patel, Lisa Rybicki, Arden Emrick, Victoria Winslow, Jamie Starn, Jamie Elberson, Brittany Hodgeman, Brad Pohlman, Brian J. Bolwell, Aaron T. Gerds, Betty K. Hamilton, Rabi Hanna, Matt Kalaycio, Navneet S. Majhail, Ronald Sobecks
Journal: Blood (2018)
Abstract 14631: Increased Cardiac Uptake of Ketone Bodies and Free Fatty Acids in Human Heart Failure and Hypertrophic Left Ventricular Remodeling
Authors: Gabor Voros, Joris Ector, Christophe Garweg, Walter Droogne, Johan Van Cleemput, Stefan Janssens, Pieter Vermeersch
Journal: Circulation (2017)

Deranged fuel supply and energy metabolism contribute to the pathophysiology of heart failure. Recent animal studies showed diminished free fatty acid (FFA) oxidation in experimental heart failure ...
GP partner is struck off for dishonesty in research
Authors: Clare Dyer
Journal: BMJ (2019)

A GP partner who conducted clinical trials for pharmaceutical companies has been struck off the medical register for enrolling ineligible patients, dishonestly altering medical records, and attempting to divert payment meant for the contract research company into his private account.

Blackpool GP Jerome Kerrane worked as a principal investigator for Fylde Coast Clinical Research, a private company that shared the premises and computer system of his practice, Layton Medical Centre. The practice had been involved in medical research since the 1980s.

Kerrane left the practice and the research company in 2015 and the partner who took over his work uncovered a string of patients who had been enrolled in trials although they failed to meet the criteria …
Recurrent Mutations in EGR2 Direct Specific Epigenetic Reconfiguration in Chronic Lymphocytic Leukemia
Authors: Christoph Weigel, Yassen Assenov, Charles Imbusch, Qi Wang, Renée Beekman, Brian Giacopelli, Yue-zhong Wu, David Brocks, Weichenhan Dieter, Popanda Odilia, Peter Schmezer, Benedikt Brors, Daniel Mertens, Karsten Rippe, Laura Z. Rassenti, Thomas J. Kipps, Jennifer A. Woyach, James S. Blachly, Elias Campo, Thorsten Zenz, John C. Byrd, José I. Martin-Subero, Christoph Plass, Christopher C. Oakes
Journal: Blood (2018)
Stimulating Oxidative DNA-Base Excision Repair in Mice Subjected to Klebsiella pneumoniae–induced Acute Respiratory Distress Syndrome (ARDS) Improves Genomic Integrity of Topoisomerase and Facilitates Innate Lung Inflammation
Authors: Cleavon J. Covington, Koa Hosoki, Jian Sha, Anirban Chakraborty, Nisha Tapryal, Julia Tripple, Victor Cardenas, Sarah Ainsworth, Tapas Hazra, Ashok Chopra, Sanjiv Sur
Journal: Journal of Allergy and Clinical Immunology (2019)
Activated protein C binds to A 50-55 KD receptor on human monocytes and inhibits cytokine production, mitogen responses and calcium signalling
Authors: W. W. Hancock, S. Grey, H. Hau, E. Akalin, A. Tsuchida, C. L. Orthner, H. Salem, M. H. Sayegh
Journal: Journal of the American Society of Nephrology (1994)
Tick-tock hedgehog-mutual crosstalk with liver circadian clock promotes liver steatosis
Authors: Eugenia Marbach-Breitrück, Madlen Matz-Soja, Ute Abraham, Wolfgang Schmidt-Heck, Susanne Sales, Christiane Rennert, Matthias Kern, Susanne Aleithe, Luise Spormann, Carlo Thiel, Raffaele Gerlini, Katrin Arnold, Nora Klöting, Reinhard Guthke, Damjana Rozman, Raffaele Teperino, Andrej Shevchenko, Achim Kramer, Rolf Gebhardt
Journal: Journal of Hepatology (2019)
DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns
Authors: Ksenia Skvortsova, Etienne Masle-Farquhar, Phuc-Loi Luu, Jenny Z. Song, Wenjia Qu, Elena Zotenko, Cathryn M. Gould, Qian Du, Timothy J. Peters, Yolanda Colino-Sanguino, Ruth Pidsley, Shalima S. Nair, Amanda Khoury, Grady C. Smith, Lisa A. Miosge, Joanne H. Reed, James G. Kench, Mark A. Rubin, Lisa Horvath, Ozren Bogdanovic, Sue Mei Lim, Jose M. Polo, Christopher C. Goodnow, Clare Stirzaker, Susan J. Clark
Journal: Cancer Cell (2019)
Abstract 1286: Increased K+ Flux into Mitochondria Confers Cardioprotection from Hypoxia
Authors: Marko Ljubkovic, Jasna Marinovic, Zeljko J Bosnjak, Martin Bienengreaber
Journal: Circulation (2006)

Increased mitochondrial K+ influx through various types of mitochondrial K+ channels has been implicated in cardioprotection during stress conditions. However, current evidence for this protective ...