tbuckley/cabot-search huggingface dataset:
Effect of Anti-CD4 Antibody UB-421 on HIV-1 Rebound after Treatment Interruption
Authors: Chang-Yi Wang, Wing-Wai Wong, Hung-Chin Tsai, Yen-Hsu Chen, Be-Sheng Kuo, Shugene Lynn, Jana Blazkova, Katherine E. Clarridge, Hsiao-Wen Su, Chia-Ying Lin, Fan-Chen Tseng, Annie Lai, Fu-Hung Yang, Chen-Han Lin, William Tseng, Hsiao-Yi Lin, Connie L. Finstad, Flossie Wong-Staal, Carl V. Hanson, Tae-Wook Chun, Mei-June Liao
Journal: New England Journal of Medicine (2019)

Administration of a single broadly neutralizing human immunodeficiency virus (HIV)–specific antibody to HIV-infected persons leads to the development of antibody-resistant virus in the absence of antiretroviral therapy (ART). It is possible that monotherapy with UB-421, an antibody that blocks the virus-binding site on human CD4+ T cells, could induce sustained virologic suppression without induction of resistance in HIV-infected persons after analytic treatment interruption.
Response to commentary by Heidari and Arabzadeh on “Worldwide and regional prevalence rates of co-occurrence of insomnia and insomnia symptoms with obstructive sleep apnea: A systematic review and meta-analysis”
Authors: Ye Zhang, Rong Ren, Fei Lei, Junying Zhou, Jihui Zhang, Yun-Kwok Wing, Larry D Sanford, Xiangdong Tang
Journal: Sleep Medicine Reviews (2019)
The impact of molecular subtype approximations on breast-conservation in breast cancer patients: A SEER-database analysis.
Authors: Kai Chen, Liling Zhu, Fengxi Su
Journal: Journal of Clinical Oncology (2015)

e12040 Background: The molecular subtype approximations defined by hormone receptor (HR) and human epithelial growth factor receptor 2 (HER2) status has significant impact on systemic therapy in breast cancer patients. Studies had shown that HER2+ subtype tends to have multifocal/multicentric lesions, extensive intraductal components and positive margins, indicating a lower likelihood of breast conservation in this subtype. However, this has never been confirmed in any population-based studies. In this study, we will use the Surveillance, Epidemiology, and End Results (SEER) database to compare the breast-conversing surgery (BCS) rates across patients with different molecular subtypes. Methods: We searched the SEER database and identified 55,430 T1-2N0-3M0 patients with breast cancer diagnosed between 2010 and 2011. In univariate and multivariate analysis, we used chi-square test and logistic regression to assess the association between molecular subtypes and BCS. Interactions between molecular subtypes and age, AJCC T-stage or AJCC N-stage were also evaluated. Results: Among patients with HR+/HER2-, HR+/HER2+, HR-/HER2+ and HR-/HER2- diseases, there were 63.6% (25,214/39,631), 51.1% (3,101/6,069), 43.4% (1,135/2,617) and 56.5% (4,019/7,113) of them had received BCS (P < 0.01), respectively. Patients with HR+/HER2+ (OR: 0.76; 95%CI 0.72-0.81) or HR-/HER2+ (OR: 0.58; 95%CI 0.53-0.63) disease were significantly less likely to receive BCS than patients with HR+/HER2- disease, after adjustment with AJCC T-stage, AJCC N-stage, age, tumor grade, county type (metropolitan vs. rural) and race. The interaction between molecular subtypes and age was noticed: the variation of the BCS rates across subtypes was smaller in < 40yrs patients (26-34%, P = 0.039) than in > = 40 yrs patients(44-64%, P < 0.001). Conclusions: Our population-based study demonstrated that the BCS rates vary significantly acorss molecular subtypes. Among all subtypes, HR-/HER2+ patients have the lowest BCS rate. Our results are informative for patient consultation in clinical practices.
Annals Story Slam - The Tables Were Turned
Authors: Brittane Parker
Journal: Annals of Internal Medicine (2019)

Web Exclusives7 May 2019Annals Story Slam - The Tables Were TurnedFREEBrittane Parker, MDBrittane Parker, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/W19-0007 SectionsAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Video. Annals Story Slam - The Tables Were Turned "The Tables Were Turned," by Dr. Brittane Parker (Duration 5:26)Building on the popular Annals feature “On Being a Doctor,” storytellers share stories about the experience of doctoring on video.For more videos from and information on Annals Story Slam, visit go.annals.org/StorySlam. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: This article was published at Annals.org on 12 April 2019. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 7 May 2019Volume 170, Issue 9Page: SS1 ePublished: 12 April 2019 Issue Published: 7 May 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.Loading ...
SAT-139-Predictive factors for the development of acute-on-chronic liver failure in a North American cohort of hospitalized patients with cirrhosis and decompensation
Authors: Florence Wong, Rajender Reddy, Puneeta Tandon, Jacqueline O’leary, Guadalupe Garcia-Tsao, Jennifer Lai, Hugo E. Vargas, Scott Biggins, Benedict Maliakkal, Michael Fallon, Ram Subramanian, Paul J. Thuluvath, Patrick S. Kamath, Leroy Thacker, Jasmohan S Bajaj
Journal: Journal of Hepatology (2019)
Abstract 20516: Aldehyde Dehydrogenase 2 Deficiency Promotes Vascular Smooth Muscle Cell Migration, Proliferation and Accelerates Neointima Formation
Authors: Hong Zhu, Nan Hu, Yingmei Zhang, Aijun Sun, Jun Ren
Journal: Circulation (2017)

Objective: Aldehyde dehydrogenase 2 (ALDH2) plays a vital role in cardiac protection following ischemia. Given the high prevalence (~ 40%) of loss-of-function for ALDH2 allele in Eastern Asian, thi...
Characterisation of children hospitalised with pneumonia in central Vietnam: a prospective study
Authors: Phuong T.K. Nguyen, Hoang T. Tran, Dominic A. Fitzgerald, Thach S. Tran, Stephen M. Graham, Ben J. Marais
Journal: European Respiratory Journal (2019)

Pneumonia is the most common reason for paediatric hospital admission in Vietnam. The potential value of using the World Health Organization (WHO) case management approach in Vietnam has not been documented.We performed a prospective descriptive study of all children (2-59 months) admitted with "pneumonia" (as assessed by the admitting clinician) to the Da Nang Hospital for Women and Children to characterise their disease profiles and assess risk factors for an adverse outcome. The disease profile was classified using WHO pneumonia criteria, with tachypnoea or chest indrawing as defining clinical signs. Adverse outcome was defined as death, intensive care unit admission, tertiary care transfer or hospital stay >10 days.Of 4206 admissions, 1758 (41.8%) were classified as "no pneumonia" using WHO criteria and only 252 (6.0%) met revised criteria for "severe pneumonia". The inpatient death rate was low (0.4% of admissions) with most deaths (11 out of 16; 68.8%) occurring in the "severe pneumonia" group. An adverse outcome was recorded in 18.7% of all admissions and 60.7% of the "severe pneumonia" group. Children were hospitalised for a median of 7 days at an average cost of 253 USD per admission. Risk factors for adverse outcome included WHO-classified "severe pneumonia", age <1 year, low birth weight, previous recent admission with an acute respiratory infection and recent tuberculosis exposure. Breastfeeding, day-care attendance and pre-admission antibiotic use were associated with reduced risk.Few hospital admissions met WHO criteria for "severe pneumonia", suggesting potential unnecessary hospitalisation and use of intravenous antibiotics. Better characterisation of the underlying diagnosis requires careful consideration.
PS-123-Biliary tree stem/progenitor cells mediate the regeneration in biliary lining after injury
Authors: Lorenzo Nevi, Vincenzo Cardinale, Wei-Yu Lu, Sabina Di Matteo, Samira Safarikia, Daniele Constantini, Fabio Melandro, Pasquale B. Berloco, Eugenio Gaudio, Stuart Forbes, Domenico Alvaro
Journal: Journal of Hepatology (2019)
Clinical significance of serum hepatocyte growth factor (sHGF) in patients with advanced non-small-cell lung cancer (NSCLC).
Authors: Takahiro Tsuji, Yuichi Sakamori, Hiroaki Ozasa, Hitomi Ajimizu, Yoshitaka Yagi, Hiroki Nagai, Michiaki Mishima, Young Hak Kim
Journal: Journal of Clinical Oncology (2015)

e19098 Background: Activation of c-MET through hepatocyte growth factor (HGF) increases tumorgenesis, induces chemoresistance, and is associated with poor prognosis in various solid tumors. However, the clinical value of serum HGF (sHGF) in patients with advanced non-small-cell lung cancer (NSCLC) receiving anticancer agents remains unknown. Methods: We retrospectively investigated the association between the level of sHGF concentration and clinical outcome in 70 patients with NSCLC receiving anticancer treatment. The sHGF levels were evaluated using ELISA at 4 time points: pretreatment, post-treatment (1-2 months after treatment initiation), best tumor response, and disease progression based on RECIST criteria. Positive sHGF was defined as more than 300 pg/ml since the minimum detectable dose of sHGF was 300 pg/ml. Results: The sHGF levels were significantly lower at post-treatment (p = 0.008, Wilcoxon rank-sum test (WRST)) and at best tumor response (p < 0.0001, WRST) than at pretreatment, and significantly higher at disease progression than at best tumor response (p < 0.001, WRST). Positive sHGF at post-treatment was an independent negative prognostic factor of progression-free survival (PFS) in multivariate analysis (median PFS, 245 vs 69 days; hazard ratio [HR], 2.64; 95%CI, 1.32 to 5.29; p = 0.0064), although positive sHGF at pretreatment was not (median PFS, 175 vs 160 days; HR, 0.96; 95% CI, 0.46 to 2.14; p = 0.934). Conclusions: These findings suggest that sHGF may be useful to predict tumor response and may also be a potential biomarker to predict PFS in patients with advanced NSCLC receiving anticancer treatment. Pretreatment Post-treatment Best response Disease progression N 53 53 47 35 sHGF-neg. (%) 16 (30.2%) 33 (62.3%) 39 (83.0%) 16 (45.7%) sHGF-pos. (%) 37 (69.8%) 20 (37.7%) 8 (17.0%) 19 (54.3%)
FRI-258-Sustained virologic response among non-cirrhotic persons who inject drugs: Results from the CanHepC retrospective hepatitis C registry
Authors: Daniel Smyth, Lisa Barrett, Julie Bruneau, Leeanna Bulinckx, Carla Coffin, Brian Conway, Shariq Haider, Samuel Lee, Gisela Macphail, Stefanie Materniak, Heidy Morales, Alnoor Ramji, Kristoffer Stewart, Edward Tam, Duncan Webster
Journal: Journal of Hepatology (2019)
TCTAP A-129 Influence of Sex on Relationship Between Total Anatomical and Physiologic Disease Burden and Their Prognostic Implications in Patients with Coronary Artery Disease
Authors: Chee Hae Kim, Bon-Kwon Koo, Joo Myung Lee, Eun-Seok Shin, Jonghanne Park, Ki Hong Choi, Doyeon Hwang, Tae-Min Rhee, Jinlong Zhang, Jin Ho Choi, Joon Hyung Doh, Chang-Wook Nam, Jian-an Wang, Shaoliang Chen, Shoichi Kuramitsu, Nobuhiro Tanaka, Hitoshi Matsuo, Takashi Akasaka
Journal: Journal of the American College of Cardiology (2019)
THU-047-Recalbration of the CLIF-C ACLF score after weighting by organ and by the presence of TIPS in patients with acute-on-chronic liver failure
Authors: Enric Reverter, Adrià Carpio, Pol Olivas, Adria Juanola, Gerhard Jung, Gabriel Mezzano, Karina Botana, Julieta Santillán, Maria Hernandez-Tejero, Fatima Aziz, Angels Escorsell, Javier Fernandez
Journal: Journal of Hepatology (2019)
Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination
Authors: Linda Hammerich, Thomas U. Marron, Ranjan Upadhyay, Judit Svensson-Arvelund, Maxime Dhainaut, Shafinaz Hussein, Yougen Zhan, Dana Ostrowski, Michael Yellin, Henry Marsh, Andres M. Salazar, Adeeb H. Rahman, Brian D. Brown, Miriam Merad, Joshua D. Brody
Journal: Nature Medicine (2019)
TCTAP C-096 Rotational Atherectomy of Critical Left Main Stenosis and Severely Calcified Right Coronary Artery in NSTE-ACS
Authors: Hou Tee Lu, Kai Ping Ang, Benjamin Leo Cheang Leng, Chu Zhen Quek, Chuey Yan Lee
Journal: Journal of the American College of Cardiology (2019)
MicroRNA (MiRNA) expression profiles in early colon cancer (CC) and lung adenocarcinoma (AC).
Authors: Marcin Tomasz Skrzypski, Michał Marczyk, Maciej Bobowicz, Piotr Czapiewski, Agnieszka Maciejewska, Ryszard Pawlowski, Joanna Polanska, Jacek Jassem
Journal: Journal of Clinical Oncology (2015)

e22062 Background: MiRNAs are short non-coding RNAs that regulate post-transcriptional gene expression and have emerged as potential useful biomarkers and therapeutic targets in various malignancies. We compared miRNA expression between early colon cancer (CC) and lung adenocarcinoma (AC) to find differences in early steps of carcinogenesis of these tumors. Methods: Expression of 752 miRNA was investigated by qRT-PCR in paraffin embedded samples of 113 stage 1 (T1N0/T2N0/T3N0) ACs and 83 stage 1-2a (T2N0/T3N0) CCs. Each tumor block was macrodissected in order to ensure at least 80% of tumor tissue. Geometrical mean of RNU48, RNU44, U6 and 9 other miRNAs selected by NormFinder algorithm was used for normalization of expression. MiRNA expression was compared between both malignancies in respect to the percentage of present expression (Ct value < 40) using Fisher test. Second analysis included miRNAs with most common expression (Ct < 40 in > 85% of the samples in each tumor) using t-test. P-values are reported after Bonferroni correction for multiple comparisons. Results: Expression of 132 miRNAs was different between CC and AC (p < 0.05). The highest differences in expression between CC and AC were detected for miR-205, miR-552, miR-192 and miR-34c-5p. MiR-552 and miR-192* were present in 98% and 100% of CC samples, and in 26% and 41% of AC samples, respectively (p < 0.001). MiR-205 and miR-34c-5p expression was present in 82% and 87% of AC and in 8% and 50% of CC samples, respectively (p < 0.001). Among miRNAs with most common expression ( > 85% of samples in both CC and AC) miR-192 expression was 5-fold higher in CC compared to AC (p = 5,47*e-06). Conclusions: Early stage CC and lung AC show large differences in miRNA expression. MiR-205 expression, earlier shown to be a marker of lung AC, retained its high specificity in comparison to CC.
PS-023-Factors predicting survival in patients with high-risk acute variceal bleeding treated with pre-emptive (Early)-TIPS
Authors: Debora Angrisani, Virginia Hernandez-Gea, Bogdan Procopet, Karel Caca, Alvaro Giraldez-Gallego, Lucio Amitrano, Maria Anna Guardascione, Candid Villanueva, Edilmar Alvarado, Dominique Thabut, Marika Rudler, Luis Ibañez, Rafael Bañares, María-Vega Catalina, Fanny Turon, Agustin Albillos, Javier Martinez, Joan Genesca, Irene Conejo Sosa, Anna Baiges, Bureau christophe, Jean Pierre Vinel, Marie-Angele Robic, Tilman Sauerbruch, Jonel TREBICKA, Beate Appenrodt, Christian Jansen, Elba Llop, José Luis Calleja Panero, Wim Laleman, Frederik Nevens, Jose María Palazon, José Castellote, Susana G. Rodrigues, Lise Lotte Gluud, Carlos Noronha Ferreira, Nuria Cañete, Marcel Tantau, Marta Magaz, Manuel Rodríguez, Arnulf Ferlitsch, Jose Luis Mundi, Henning Grønbæk, Manuel Hernandez-Guerra, José Ferrusquia, Joachim Mössner, Romanno Sassatelli, Alessandra Dell'Era, Marco Senzolo, Juan G ABRALDES, Manuel Romero Gomez, Alexander Zipprich, Angelo Luca, Meritxell Casas, Helena Masnou, Massimo Primignani, Georgina Casanovas, Ferran Torres, Aleksander Krag, Jaime Bosch, Alberto Monescillo, Juan-Carlos GARCIA-PAGAN
Journal: Journal of Hepatology (2019)
THU-393-HCV infection in Canadian immigrants: Characteristics and treatment outcomes of the CANUHC cohort
Authors: Curtis Cooper, Marie-Louise Vachon, Brian Conway, Alexander Wong, Alnoor Ramji, Sergio Borgia, Edward Tam, Lisa Barrett, Daniel Smyth, Heidy Morales, Chrissi Galanakis, Jordan Feld, Samuel Lee
Journal: Journal of Hepatology (2019)
SAT-296-Oxidized LDL is a distinctive biomarker of NASH independently of liver fibrosis in patients with NAFLD
Authors: Rocío Gallego-Durán, Javier Ampuero, Helena Pastor-Ramírez, Jose Antonio Del Campo Castillo, Jesús María Banales, Javier Crespo, Carmelo García-Monzón, Rocío Montero-Vallejo, Alvaro Santos-Laso, María Teresa Arias Loste, Águeda Gónzalez-Rodriguez, Raquel Millan, María del Carmen Rico, Angela Rojas, Antonio Gil-Gomez, Rocio Munoz hernandez, Sheila Gato, Douglas Maya-Miles, Manuel Romero Gomez
Journal: Journal of Hepatology (2019)
Abstract 16421: Follow-Up of Subclinical Rheumatic Heart Disease in Children
Authors: Mariana Mirabel, Thomas Fauchier, Muriel Tafflet, Raoul Bacquelin, Bernard Rouchon, Eloi Marijon, Xavier Jouven
Journal: Circulation (2013)

Introduction: The concept of subclinical RHD emerged from echocardiography screening for Rheumatic Heart Disease (RHD). However, the pathogenicity and prognostic value of this new entity are stil...
FRI-032-Liver transplantation ameliorates chronic fatigue and improves quality of life in patients with primary sclerosing cholangitis
Authors: Marcin Krawczyk, Karolina Wronka, Katarzyna Kotarska, Marta Przedniczek, Maciej K. Janik, Raszeja-Wyszomirska Joanna, Maciej Wójcicki, Piotr Milkiewicz
Journal: Journal of Hepatology (2019)
Detecting Pathological Complete Response in Esophageal Cancer after Neoadjuvant Therapy Based on Imaging Techniques: A Diagnostic Systematic Review and Meta-Analysis
Authors: Didi J.J.M. de Gouw, Bastiaan R. Klarenbeek, Mitchell Driessen, Stefan A.W. Bouwense, Frans van Workum, Jurgen J. Fütterer, Maroeska M. Rovers, Richard P.G. ten Broek, Camiel Rosman
Journal: Journal of Thoracic Oncology (2019)
Abstract 17045: Alternative Splicing of Pyruvate Kinase Indicates Metabolic Shift After Myocardial Infarction
Authors: Allison L Williams, Vedbar Khadka, Abigail Avelar, Mingxin Tang, Ralph Shohet
Journal: Circulation (2017)

Introduction: Alternative splicing of mRNA is an increasingly recognized mechanism for cells to rapidly alter protein function in response to environmental stimuli. Ischemic injury dramatically mod...
Unemployment risk and decreased income 2 and 4 years after thyroid cancer diagnosis: A population based study.
Authors: Beatrice Uziely, Navah Ratzon, Yakir Rottenberg
Journal: Journal of Clinical Oncology (2015)

e20618 Background: Thyroid cancer is a disease of relatively young patients with a high cure rate. On the other hand, high rates of fatigue remain even after a long period following diagnosis. The aim of the project was to clarify the association between unemployment risk and decreasing income change at 2 and 4 years after diagnosis of thyroid cancer. Methods: A historical prospective study was designed, with cohort inception and baseline measurement of people participating in the Israeli Central Bureau of Statistics 1995 National Census, and follow up until 2011. Cancer incidence and employment status were ascertained through the Israel Cancer Registry and Tax Authority, respectively. A matched group in a ratio of 4:1 according to age and ethnicity was sampled from the population in the census. Binary logistic regression analyses were used to assess hazard ratios for study’s outcomes, while controlling for age, sex, ethnicity, education years, socioeconomic position and status of employment at 2 years prior to diagnosis. Results: A total of 481 cases of thyroid cancer and 1459 non-cancer healthy controls in the matched group were included in the study after excluding persons who died during the study period. The mean age was 43.3 years in the group of thyroid cancer and 46.5 years in the match group (p = 0.9). A positive significant association between thyroid cancer and risk of unemployment 2 years after diagnosis (HR = 1.41, 95%CI: 1.07-1.86), decreased income 2 years after diagnosis (HR = 1.55, 95%CI: 1.20-2.01) and at 4 years after diagnosis (HR = 1.66, 95%CI: 1.28-2.15) were found after controlling for potential confounders. In contrast, the association between thyroid cancer and unemployment 4 years after diagnosis was found to weaken and actually lose significance (HR = 1.27, 95%CI: 0.97-1.66). Conclusions: Thyroid cancer survivorship is associated with subsequent unemployment at 2 years and decreased income at 2 and 4 years, while income decreasing may be a marker for shifting to part time work rather than full return for work. On a more practical note, the clinical ramifications of our findings suggest that intervention in order to enhance return to full work is required at this population.
Role of neck dissection or radiotherapy in breast cancer patients with supraclavicular nodal metastasis.
Authors: Ting-Shuo Huang, Shih Che Shen, Yung-Chang Lin, Chi-Chang Yu, Hsien-Kun Chang, Yi-Ting Huang, Shir-Hwa Ueng, Shin-Cheh Chen
Journal: Journal of Clinical Oncology (2015)

e12041 Background: To investigate the efficacy of local control modalities, including modified neck dissection (ND) and radiotherapy (RT) in addition to systemic chemotherapy (CT) in terms of distant metastasis-free survival (DMFS) and overall survival (OS) in breast cancer patients with isolated supraclavicular neck lymph node metastasis (SLNM) after primary surgery. Methods: Between 1990 and 2006, 6878 consecutive women who underwent surgery for primary breast cancer in a single institute were identified. Eighty-eight patients presented with isolated SLNM without distant metastasis. Primary outcomes were DMFS (duration from neck relapse to distant metastasis) and OS (duration from neck relapse to death). For causal inference, we conducted inverse probability treatment weighting based on a structural causal model to adjust confoudnings and the marginal structural Cox model to estimate causal effects. Results: Of 88 (1.3%) patients with SLNM, all received salvage CT, while 36 patients received ND before CT, 25 received RT after CT and 27 received CT alone. The median follow-up was 43.5 months. During follow-up, 69 patients were found to have distant metastasis, and 68 patients died. According to the marginal structure Cox model (using relapse within 2 years as the effect modifier), DMFS and OS were significantly better in the ND+CT and RT+CT groups than in the CT group among patients with relapse after 2 years (hazard ratios [HRs] for DMFS = 0.24 (0.11–0.54) for ND+CT versus CT and 0.24 (0.08–0.71) for RT+CT versus CT; HRs for OS = 0.33 (0.15–0.72) for ND+CT versus CT and 0.33 (0.12–0.93) for RT+CT versus CT). However, for patients who relapsed within two years, treatment with ND+CT or RT+CT did not significantly improve DMFS (HR = 0.58 [0.22–1.50] and 0.72 [0.15–3.50], respectively) or OS (HR = 1.09 [0.51–2.30] and 0.95 [0.25–3.69], respectively) compared to treatment with CT alone. Conclusions: Our long-term follow-up study demonstrated that local control (both ND and RT) significantly improved DMFS and OS among selected patients with SLNM. It suggests that not all patients with SLNM after surgery should be categorized as distant metastasis. Further studies are needed to confirm our findings.