tbuckley/cabot-search huggingface dataset:
FRI0415 BODY MASS INDEX AND STATIC FOOT DISORDERS IN GONARTHROSIC PATIENTS
Authors: K. Maatallah, M. Hfaidh, H. Ferjani, W. Triki, D. Kaffel, W. Hamdi
Journal: Annals of the Rheumatic Diseases (2020)

Background: Several studies have shown that there is a link between body mass index (BMI) and painful foot imputed to a biomechanical change in foot structure [1]. Objectives: Our objective was to study the association between BMI and static foot disorders in gonarthrosic subjects. Methods: It was a prospective descriptive study conducted in the rheumatology department of the Mohamed Kassab Institute of Orthopedics with 60 patients with Gonarthrosis. The socio-demographic data of the patients were studied. BMI was calculated for all patients. Static foot disorders have been studied. Results: Sixty patients were included, 83.3% of whom were female. The average age was 55.2 years [38-78 years]. The disease has been evolving for an average of 6 years [1-13 years]. The lesion was bilateral in 80% of cases, the average body mass index was 30.4 kg / m2 [24-36]. Knee arthritis was classified as stage I, II and III according to the Kellgren and Lawrence classification in 18.5%, 55.6% and 25.9% of patients respectively. The foot examination involved 108 gonarthrosic limbs. Examination of the integuments showed hyperkeratosis in 94.4% of the cases (79.6% calluses and 83.3% callosities). Forefoot deformities were Hallux valgus (HV) in 52.8% of cases and overlapping toes in 18.5% of cases. Pronation deformity using the Foot Posture Index (FPI) was found in 51.9% of cases. Abnormal lowering of navicular bone was noted in 51.9%. The podoscopic impression revealed flat feet in 73.2% of the cases. A statistically significant association was found between BMI and the presence of calluses (31.21 ± 2.897 vs26.83 ± 1.425, p &lt;0.001), with HV (31.37 ± 3.086 vs29.49 ± 2.969, p = 0.002), at the overlap of the toes (33.2 ± 1.361vs29.86 ± 1.130, p &lt;0.001), with the lowering of the navicular bone (31.17 ± 2.885vs29.68 ± 3.304, p = 0.015), FPI (p = 0.003) and flat podoscopic impression (p &lt;0.001). Conclusion: BMI is strongly associated with static feet disorders in gonarthrosic patients by aggravating the postural changes in the foot caused by knee osteoarthritis [2]. Obesity is associated mainly with the existence of flat feet, pronation of the foot, toes deformities and hyperkeratosis. References: [1]Steele JR, Mickle KJ, Munro B. Fat flat frail feet: how does obesity affect the older foot. XXII Congress of the International Society of Biomechanics; 2009 [2]Norton AA, Callaghan JJ, Amendola A, Phisitkul P, Wongsak S, Liu SS, et al. Correlation of knee and hindfoot deformities in advanced knee OA: compensatory hindfoot alignment and where it occurs. Clin Orthop Relat Res. 2015;473(1):166-74 Disclosure of Interests: None declared
Proteomic analysis of nasal mucus samples of healthy patients and patients with chronic rhinosinusitis
Authors: Stephen Shih-Teng Kao, Ahmed Bassiouni, Mahnaz Ramezanpour, John Finnie, Nusha Chegeni, Alex D. Colella, Timothy K. Chataway, Peter-John Wormald, Sarah Vreugde, Alkis James Psaltis
Journal: Journal of Allergy and Clinical Immunology (2020)
Immigrant COVID
Authors: Paul Rousseau
Journal: Annals of Internal Medicine (2020)

Ad Libitum20 October 2020Immigrant COVIDFREEPaul Rousseau, MDPaul Rousseau, MDCharleston, South Carolina (P.R.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M20-4732 Audio Reading - “Immigrant COVID” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads “Immigrant COVID” by Paul Rousseau, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail With fever and cough and gasping breath, he shuffles into the exam room tracing the wall with his hand like a blind man fingering Braille, apologizing that he might have COVID, but the slaughterhouse won't let him work until he's tested, and if he doesn't work, the slaughterhouse notifies the Border Patrol, and yes, he's illegal, five years now, and yes, his wife and three children are also sick, and no, he doesn't have health insurance, and when the swab tickles the back of his throat he coughs and sneezes, and I stumble sideward and ponder the scattered droplets and my family at home. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: Charleston, South Carolina (P.R.)Current Author Address: Paul Rousseau, MD, 1531 Wakendaw Road, Mount Pleasant, SC 29464; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement Audio Reading - “Immigrant COVID” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads “Immigrant COVID” by Paul Rousseau, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 20 October 2020Volume 173, Issue 8Page: 667KeywordsChildrenFeversHealth insurancePharynx ePublished: 4 August 2020 Issue Published: 20 October 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Pulmonary <i>Staphylococcus aureus</i> infection regulates breast cancer cell metastasis via neutrophil extracellular traps (NETs) formation
Authors: Jia‐Long Qi, Jin‐Rong He, Cun‐Bao Liu, Shu‐Mei Jin, Rui‐Yu Gao, Xu Yang, Hong‐Mei Bai, Yan‐Bing Ma
Journal: MedComm (2020)

The formation of neutrophil extracellular traps (NETs) was recently identified as one of the most important processes for the maintenance of host tissue homeostasis in bacterial infection. Meanwhile, pneumonia infection has a poor effect on cancer patients receiving immunotherapy. Whether pneumonia-mediated NETs increase lung metastasis remains unclear. In this study, we identified a critical role for multidrug-resistant Staphylococcus aureus infection-induced NETs in the regulation of cancer cell metastasis. Notably, S. aureus triggered autophagy-dependent NETs formation in vitro and in vivo and increased cancer cell metastasis. Targeting autophagy effectively regulated NETs formation, which contributed to the control of cancer metastasis in vivo. Moreover, the degradation of NETs by DNase I significantly suppresses metastasis in lung. Our work offers novel insight into the mechanisms of metastasis induced by bacterial pneumonia and provides a potential therapeutic strategy for pneumonia-related metastasis.
Abstract 16503: Racial Disparities in Early Subclinical Atherosclerosis: Insights from the FAMILIA Study
Authors: Rodrigo Fernandez-Jimenez, Latifa Benkader, Christine Graziano-Zill, Raquel Diaz-Munoz, Risa Jaslow, Jacqueline Latina, Ana V Soto, Andrea Clarke-Littman, Monali Fatterpekar, Sameer Bansilal, Rajesh Vedanthan, Jason Kovacic, Andrew Kasarskis, Roger J Hajjar, Daniella Kadian-Dodov, Zahi Fayad, Valentin Fuster
Journal: Circulation (2018)

Introduction: African-Americans are at a greater risk of cardiovascular (CV) events. Differential race vulnerability to early subclinical atherosclerosis disease is likely, and yet few studies have...
Deaths and Years of Potential Life Lost From Excessive Alcohol Use — United States, 2011–2015
Authors: Marissa B. Esser, Adam Sherk, Yong Liu, Timothy S. Naimi, Timothy Stockwell, Mandy Stahre, Dafna Kanny, Michael Landen, Richard Saitz, Robert D. Brewer
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

Excessive alcohol use is a leading cause of preventable death in the United States (1) and costs associated with it, such as those from losses in workplace productivity, health care expenditures, and criminal justice, were $249 billion in 2010 (2). CDC used the Alcohol-Related Disease Impact (ARDI) application* to estimate national and state average annual alcohol-attributable deaths and years of potential life lost (YPLL) during 2011-2015, including deaths from one's own excessive drinking (e.g., liver disease) and from others' drinking (e.g., passengers killed in alcohol-related motor vehicle crashes). This study found an average of 93,296 alcohol-attributable deaths (255 deaths per day) and 2.7 million YPLL (29 years of life lost per death, on average) in the United States each year. Of all alcohol-attributable deaths, 51,078 (54.7%) were caused by chronic conditions, and 52,361 (56.0%) involved adults aged 35-64 years. Age-adjusted alcohol-attributable deaths per 100,000 population ranged from 20.3 in New Jersey and New York to 52.3 in New Mexico. YPLL per 100,000 population ranged from 613.8 in New York to 1,651.7 in New Mexico. Implementation of effective strategies for preventing excessive drinking, including those recommended by the Community Preventive Services Task Force (e.g., increasing alcohol taxes and regulating the number and concentration of alcohol outlets), could reduce alcohol-attributable deaths and YPLL.†.
Phase I trial of rituximab, cladribine, and temsirolimus (RCT) for initial therapy of mantle cell lymphoma
Authors: D.J. Inwards, P.A. Fishkin, B.R. LaPlant, M.T. Drake, P.J. Kurtin, D.A. Nikcevich, D.B. Wender, B.S. Lair, T.E. Witzig
Journal: Annals of Oncology (2018)

Ann Oncol 2014; 25: 2020–2024 (doi: 10.1093/annonc/mdu273) The following funding statement was missing from the original manuscript: ‘Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under Award Numbers U10CA180821 and U10CA180882 (to the Alliance for Clinical Trials in Oncology). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Also supported in part by funds from Wyeth Pharmaceuticals. Wyeth was subsequently purchased by Pfizer Pharmaceuticals.’ This has now been amended in the online version. Phase I trial of rituximab, cladribine, and temsirolimus (RCT) for initial therapy of mantle cell lymphomaAnnals of OncologyVol. 25Issue 10PreviewWe conducted this trial to determine the maximum tolerated dose (MTD) of temsirolimus added to an established regimen comprised of rituximab and cladribine for the initial treatment of mantle cell lymphoma. Full-Text PDF Open Archive
Risk of COVID-19 among front-line health-care workers and the general community: a prospective cohort study
Authors: Long H Nguyen, David A Drew, Mark S Graham, Amit D Joshi, Chuan-Guo Guo, Wenjie Ma, Raaj S Mehta, Erica T Warner, Daniel R Sikavi, Chun-Han Lo, Sohee Kwon, Mingyang Song, Lorelei A Mucci, Meir J Stampfer, Walter C Willett, A Heather Eliassen, Jaime E Hart, Jorge E Chavarro, Janet W Rich-Edwards, Richard Davies, Joan Capdevila, Karla A Lee, Mary Ni Lochlainn, Thomas Varsavsky, Carole H Sudre, M Jorge Cardoso, Jonathan Wolf, Tim D Spector, Sebastien Ourselin, Claire J Steves, Andrew T Chan, Christine M. Albert, Gabriella Andreotti, Bijal Bala, Bijal A. Balasubramanian, Laura E. Beane-Freeman, John S. Brownstein, Fiona J. Bruinsma, Joe Coresh, Rui Costa, Annie N. Cowan, Anusila Deka, Sandra L. Deming-Halverson, Maria Elena Martinez, Michael E. Ernst, Jane C. Figueiredo, Pedro Fortuna, Paul W. Franks, Laura Beane Freeman, Christopher D. Gardner, Irene M. Ghobrial, Christopher A. Haiman, Janet E. Hall, Jae H. Kang, Brenda Kirpach, Karestan C. Koenen, Laura D. Kubzansky, James V. Lacey, Jr, Loic Le Marchand, Xihong Lin, Pam Lutsey, Catherine R. Marinac, Maria Elena Martinez, Roger L. Milne, Anne M. Murray, Denis Nash, Julie R. Palmer, Alpa V. Patel, Eric Pierce, McKaylee M. Robertson, Lynn Rosenberg, Dale P. Sandler, Shepherd H. Schurman, Kara Sewalk, Shreela V. Sharma, Christopher J. Sidey-Gibbons, Liz Slevin, Jordan W.. Smoller, Claire J. Steves, Maarit I. Tiirikainen, Scott T. Weiss, Lynne R. Wilkens, Feng Zhang
Journal: The Lancet Public Health (2020)

Data for front-line health-care workers and risk of COVID-19 are limited. We sought to assess risk of COVID-19 among front-line health-care workers compared with the general community and the effect of personal protective equipment (PPE) on risk.
Long-read-based human genomic structural variation detection with cuteSV
Authors: Tao Jiang, Yongzhuang Liu, Yue Jiang, Junyi Li, Yan Gao, Zhe Cui, Yadong Liu, Bo Liu, Yadong Wang
Journal: Genome biology (2020)

Abstract Long-read sequencing is promising for the comprehensive discovery of structural variations (SVs). However, it is still non-trivial to achieve high yields and performance simultaneously due to the complex SV signatures implied by noisy long reads. We propose cuteSV, a sensitive, fast, and scalable long-read-based SV detection approach. cuteSV uses tailored methods to collect the signatures of various types of SVs and employs a clustering-and-refinement method to implement sensitive SV detection. Benchmarks on simulated and real long-read sequencing datasets demonstrate that cuteSV has higher yields and scaling performance than state-of-the-art tools. cuteSV is available at https://github.com/tjiangHIT/cuteSV .
Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS–CoV-2
Authors: Caroline Diorio, Sarah E. Henrickson, Laura A. Vella, Kevin O. McNerney, Julie Chase, Chakkapong Burudpakdee, Jessica H. Lee, Cristina Jasen, Fran Balamuth, David M. Barrett, Brenda L. Banwell, Kathrin M. Bernt, Allison M. Blatz, Kathleen Chiotos, Brian T. Fisher, Julie C. Fitzgerald, Jeffrey S. Gerber, Kandace Gollomp, Christopher Gray, Stephan A. Grupp, Rebecca M. Harris, Todd J. Kilbaugh, Audrey R. Odom John, Michele Lambert, Emily J. Liebling, Michele E. Paessler, Whitney Petrosa, Charles Phillips, Anne F. Reilly, Neil D. Romberg, Alix Seif, Deborah A. Sesok-Pizzini, Kathleen E. Sullivan, Julie Vardaro, Edward M. Behrens, David T. Teachey, Hamid Bassiri
Journal: Journal of Clinical Investigation (2020)

BACKGROUND. Initial reports from the severe acute respiratory coronavirus 2 (SARS–CoV-2) pandemic described children as being less susceptible to coronavirus disease 2019 (COVID-19) than adults. Subsequently, a severe and novel pediatric disorder termed multisystem inflammatory syndrome in children (MIS-C) emerged. We report on unique hematologic and immunologic parameters that distinguish between COVID-19 and MIS-C and provide insight into pathophysiology.
Abstract 18957: Plaque Vulnerability Assessment by Coronary Artery Remodeling Using 320-Slice Computed Tomography Angiography
Authors: Sadako Motoyama, Masayoshi Sarai, Hideki Kawai, Hiroto Harigaya, Hiroyuki Naruse, Junnichi Ishii, Yukio Ozaki, Jagat Narula
Journal: Circulation (2010)

Purpose: Culprit plaques resulting in acute coronary syndromes are usually large and demonstrate low attenuation (LAP) and positive remodeling (PR) on CT angiography (CTA). When identified in non-A...
Endometrial Cancer Molecular Risk Stratification is Equally Prognostic for Endometrioid Ovarian Carcinoma
Authors: Pauline Krämer, Aline Talhouk, Mary Anne Brett, Derek S. Chiu, Evan S. Cairns, Daniëlla A. Scheunhage, Rory F.L. Hammond, David Farnell, Tayyebeh M. Nazeran, Marcel Grube, Zhouchunyang Xia, Janine Senz, Samuel Leung, Lukas Feil, Jana Pasternak, Katherine Dixon, Andreas Hartkopf, Bernhard Krämer, Sara Brucker, Florian Heitz, Andreas du Bois, Philipp Harter, Felix K.F. Kommoss, Hans-Peter Sinn, Sabine Heublein, Friedrich Kommoss, Hans-Walter Vollert, Ranjit Manchanda, Cornelis D. de Kroon, Hans W. Nijman, Marco de Bruyn, Emily F. Thompson, Ali Bashashati, Jessica N. McAlpine, Naveena Singh, Anna V. Tinker, Annette Staebler, Tjalling Bosse, Stefan Kommoss, Martin Köbel, Michael S. Anglesio
Journal: Clinical Cancer Research (2020)

Abstract Purpose: Endometrioid ovarian carcinoma (ENOC) is generally associated with a more favorable prognosis compared with other ovarian carcinomas. Nonetheless, current patient treatment continues to follow a “one-size-fits-all” approach. Even though tumor staging offers stratification, personalized treatments remain elusive. As ENOC shares many clinical and molecular features with its endometrial counterpart, we sought to investigate The Cancer Genome Atlas–inspired endometrial carcinoma (EC) molecular subtyping in a cohort of ENOC. Experimental Design: IHC and mutation biomarkers were used to segregate 511 ENOC tumors into four EC-inspired molecular subtypes: low-risk POLE mutant (POLEmut), moderate-risk mismatch repair deficient (MMRd), high-risk p53 abnormal (p53abn), and moderate-risk with no specific molecular profile (NSMP). Survival analysis with established clinicopathologic and subtype-specific features was performed. Results: A total of 3.5% of cases were POLEmut, 13.7% MMRd, 9.6% p53abn, and 73.2% NSMP, each showing distinct outcomes (P &amp;lt; 0.001) and survival similar to observations in EC. Median OS was 18.1 years in NSMP, 12.3 years in MMRd, 4.7 years in p53abn, and not reached for POLEmut cases. Subtypes were independent of stage, grade, and residual disease in multivariate analysis. Conclusions: EC-inspired molecular classification provides independent prognostic information in ENOC. Our findings support investigating molecular subtype–specific management recommendations for patients with ENOC; for example, subtypes may provide guidance when fertility-sparing treatment is desired. Similarities between ENOC and EC suggest that patients with ENOC may benefit from management strategies applied to EC and the opportunity to study those in umbrella trials.
The integrin-linked kinase is required for chemokine-triggered high-affinity conformation of the neutrophil β2-integrin LFA-1
Authors: Andreas Margraf, Giulia Germena, Hannes C. A. Drexler, Jan Rossaint, Nadine Ludwig, Barbara Prystaj, Sina Mersmann, Katharina Thomas, Helena Block, Wiebke Gottschlich, Chang Liu, Peter W. Krenn, Hermann Haller, Barbara Heitplatz, Marika Meyer zu Brickwedde, Markus Moser, Dietmar Vestweber, Alexander Zarbock
Journal: Blood (2020)
Natural born talents undiscovered - Response
Authors: Mja Howe, JW Davidson, JA Sloboda
Journal: Behavioral and Brain Sciences (1998)

This Response addresses eight issues raised in the 
commentaries: (1) the question of how innate talents should 
be defined; (2) relationships between the talent account and 
broader views concerning genetic variability; (3) the quality 
of the empirical evidence for and against the talent account; 
(4) the possible involvement of innate influences on specific 
abilities; (5) the possibility of talent-like phenomena in autistic 
savants; (6) alternative explanations of exceptional expertise at 
skills; (7) practical and educational implications of the talent 
account and alternative positions. Finally, (8), we conclude by 
discussing the impact of the commentaries on our own views.
Future role for adoptive T-cell therapy in checkpoint inhibitor-resistant metastatic melanoma
Authors: Troels Holz Borch, Rikke Andersen, Eva Ellebaek, Özcan Met, Marco Donia, Inge Marie Svane
Journal: Journal for ImmunoTherapy of Cancer (2020)

Personalized cell therapy targeting tumor antigens with expanded tumor-infiltrating lymphocytes (TILs) has shown great promise in metastatic melanoma (MM) since the 90s. However, MM was first-in line to benefit from the wave of checkpoint inhibitors (CPI), which shifted the focus of immunotherapy almost fully to immune CPI. Still, the majority of patients fail to benefit from CPI treatment, raising the intriguing question on how TIL therapy may fit into the changing landscape of melanoma treatment. We took advantage of data from a unique cohort of patients with MM treated with T-cell therapy in consecutive clinical trials at our institution across the last 10 years. Based on detailed data on patient characteristics, pre-TIL and post-TIL treatments and long-term follow-up, we were able to address the important issue of how TIL therapy can be positioned in the current CPI era. We found that previous progression on anticytotoxic T-lymphocyte-associated protein 4 do not seem to harm neither rate nor duration of response to TIL therapy. Importantly, even in the hard-to-treat population of patients who progressed on antiprogrammed cell death protein 1 (anti-PD-1), an objective response rate of 32% was achieved, including durable responses. Yet, median progression-free survival was reduced in this anti-PD-1 refractory population. Trial registration number: ClinicalTrials.gov ID: NCT00937625 , NCT02379195 and NCT02354690 .
Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to Diabetes Incidence Among American Young Adults: A 30-Year Follow-up Study
Authors: Jie Zhu, Cheng Chen, Liping Lu, Kefeng Yang, Jared Reis, Ka He
Journal: Diabetes Care (2020)

OBJECTIVE To prospectively examine intakes of folate, vitamin B6, and vitamin B12 in relation to diabetes incidence in a large U.S. cohort. RESEARCH DESIGN AND METHODS A total of 4,704 American adults aged 18–30 years and without diabetes were enrolled in 1985–1986 and monitored until 2015–2016 in the Coronary Artery Risk Development in Young Adults (CARDIA) study. Dietary assessment was conducted by a validated dietary history questionnaire at baseline, in 1992–1993, and in 2005–2006. The cumulative average intakes of folate, vitamin B6, and vitamin B12 were used in the analyses. Incident diabetes was ascertained by plasma glucose levels, oral glucose tolerance tests, hemoglobin A1c concentrations, and/or antidiabetic medications. RESULTS During 30 years (mean 20.5 ± 8.9) of follow-up, 655 incident cases of diabetes occurred. Intake of folate, but not vitamin B6 or vitamin B12, was inversely associated with diabetes incidence after adjustment for potential confounders. Compared with the lowest quintile of total folate intake, the multivariable-adjusted hazard ratios (95% CI) in quintiles 2–5 were 0.85 (0.67–1.08), 0.78 (0.60–1.02), 0.82 (0.62–1.09), and 0.70 (0.51–0.97; Ptrend = 0.02). Higher folate intake was also associated with lower plasma homocysteine (Ptrend &amp;lt; 0.01) and insulin (Ptrend &amp;lt; 0.01). Among supplement users, folate intake was inversely associated with serum C-reactive protein levels (Ptrend &amp;lt; 0.01). CONCLUSIONS Intake of folate in young adulthood was inversely associated with diabetes incidence in midlife among Americans. The observed association may be partially explained by mechanisms related to homocysteine level, insulin sensitivity, and systemic inflammation.
Abstract 12574: Mindfulness and Lifestyle Medicine Lowers Blood Pressure in Hypertension
Authors: Eunjoo An, Mary-Lynn Brecht, Lynn V Doering, Michael R Irwin, Karol E Watson, Paul M Macey
Journal: Circulation (2019)

Introduction: HTN is the leading modifiable cardiovascular risk factor affecting 103 million adults in the US. A healthy diet and regular physical activity are key components in lifestyle medicine ...