Recommendations for Essential Esophageal Physiologic Testing During the COVID-19 Pandemic
Authors: Yeong Yeh Lee, Albert J. Bredenoord, C. Prakash Gyawali
Journal: Clinical Gastroenterology and Hepatology (2020)

The first human case of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was reported in Wuhan, China, in December 2019.1Zhang J. Litvinova M. Wang W. et al.Evolving epidemiology and transmission dynamics of coronavirus disease 2019 outside Hubei province, China: a descriptive and modelling study.Lancet Infect Dis. 2020 Apr 2; ([E-pub ahead of print])Abstract Full Text Full Text PDF Scopus (409) Google Scholar As of April 17, 2020, the World Health Organization estimated that more than 2 million people had been infected in 184 countries around the globe, with 145,000 deaths, with the United States currently most affected. In this unprecedented COVID-19 pandemic, routine clinical services are severely disrupted, with as much healthcare personnel and resources as possible deployed to the frontlines. As countries, regions, and cities have imposed lockdown measures, gastrointestinal motility laboratories have been ordered by hospital authorities to close their services for an indeterminate period of time. Esophageal physiologic testing is among the many clinical procedures that are considered nonemergent, as high-resolution manometry (HRM), pH, and pH impedance studies are performed for non–life-threatening indications. Many physicians, including the authors, are struggling with patients who suffer from refractory undiagnosed gastrointestinal symptoms, who could benefit from esophageal physiologic testing to triage management. How are gastroenterologists managing esophageal symptoms to function under these extraordinary circumstances? Clearly, accepted indications for esophageal physiologic testing2Trudgill N.J. Sifrim D. Sweis R. et al.British Society of Gastroenterology guidelines for oesophageal manometry and oesophageal reflux monitoring.Gut. 2019; 68: 1731-1750Crossref PubMed Scopus (50) Google Scholar,3Savarino E. de Bortoli N. Bellini M. et al.Practice guidelines on the use of esophageal manometry: a GISMAD-SIGE-AIGO medical position statement.Dig Liver Dis. 2016; 48: 1124-1135Abstract Full Text Full Text PDF PubMed Scopus (79) Google Scholar cannot be implemented because guidelines for social distancing impact elective interactions between patients and healthcare providers. In the absence of guidance regarding emergent indications for esophageal physiologic testing in the COVID-19 era, we have developed practical guidelines for triaging patients for safe performance of some of these tests, in settings in which management decisions could be expedited to relieve patient symptoms and prevent complications, while simultaneously shortening hospital stay. Aerosolizing procedures in settings in which the patient's infectious status is unknown can impact healthcare providers performing aerodigestive and gastrointestinal procedures.4Repici A. Maselli R. Colombo M. et al.Coronavirus (COVID-19) outbreak: what the department of endoscopy should know.Gastrointest Endosc. 2020 Mar 14; ([E-pub ahead of print])Abstract Full Text Full Text PDF Scopus (393) Google Scholar While endotracheal intubation, bronchoscopy, and upper endoscopy are anticipated to aerosolize the most, one can anticipate that nasal intubation of manometry and pH/pH impedance catheters will generate coughing, retching, and aerosolization. While there is no conclusive evidence that endoscopy and esophageal physiologic testing transmit viruses such as SARS-CoV-2,5Repici A. Aragona G. Cengia G. et al.Low risk of COVID-19 transmission in GI endoscopy.Gut. 2020 Apr 22; ([E-pub ahead of print])Crossref Scopus (102) Google Scholar these procedures are being severely limited out of an abundance of caution in absence of evidence to the contrary. However, some patients with esophageal symptoms may have obstructive motor disease needing urgent management, while others may be regurgitating in the context of severe reflux and pulmonary disease, and both are at risk for aspiration. In modern healthcare systems in which clinical practice needs exist in a continuum, there is often difficulty in separating what is elective from what is emergent. We have developed a scheme for identifying patients at highest risk for adverse consequences if esophageal physiologic testing is not performed, those that need testing within weeks and cannot wait months, and others that have purely elective indications (Table 1). These recommendations could be useful in triaging patients during the current lockdown but will also be useful in prioritizing testing on the backlog of patients once clinical activities resume. We emphasize that the alternatives offered are not equivalent to the optimal physiologic test indicated (eg, barium esophagogram may overlook spastic achalasia, in contrast to HRM). The use of the listed inferior alternatives should therefore always be balanced against delaying the diagnostic esophageal physiologic test until this can be safely performed.Table 1Triaging Patients for Esophageal Physiologic TestingClinical QualifiersAlternativeEmergent/urgent proceduresHRM in suspected achalasiaSignificant dysphagia, weight loss, regurgitationEndoscopy with intubation and FLIPBarium esophagographyHRM prior to achalasia managementPlans for urgent management (PD or myotomy)Endoscopy with intubation and FLIP/botulinum toxin injectionBarium esophagographyHRM prior to antireflux surgeryLarge hiatus hernia, risk for aspiration, pulmonary disease requiring lung transplantationBarium esophagographySemiurgent proceduresDysphagia with weight loss (transition to an urgent HRM procedure if nutrition is compromised over 2–4 wk)Frequent/daily symptomsImpacting quality of lifeNegative endoscopy/bariumEmpiric management with PPI, soft/liquid dietDysphagia without weight lossFrequent/daily symptomsImpacting quality of lifeNegative endoscopy/bariumEmpiric management with PPI, soft/liquid dietChest painFrequent/daily symptomsImpacting quality of lifeNegative endoscopy/bariumEmpiric management with PPI, pain modulatorsElective proceduresHRM/reflux monitoring for reflux symptoms prior to antireflux surgery or with incomplete PPI responseElective, can be postponedMedical reflux management, pain modulators, lifestyle measuresHRM in behavioral symptoms/suspected supragastric belching/ruminationElective, can be postponedRemote cognitive and behavioral therapy, diaphragmatic breathingFLIP, functional lumen imaging probe; HRM, high resolution manometry; PD, pneumatic dilation; PPI, proton pump inhibitor. Open table in a new tab FLIP, functional lumen imaging probe; HRM, high resolution manometry; PD, pneumatic dilation; PPI, proton pump inhibitor. Before considering even emergent or urgent motility testing during the pandemic, it is essential to establish that operating procedures in the motility laboratory ensure safe practice for both patients and staff. The SARS-CoV-2 virus remains viable in aerosols for hours and on surfaces for days but is easily killed due to its porous lipid shell.6van Doremalen N. Bushmaker T. Morris D.H. et al.Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1.N Engl J Med. 2020; 382: 1564-1567Crossref PubMed Scopus (6789) Google Scholar Despite viral shedding in stool, risk of fecal transmission remains unclear.7Xiao F. Tang M. Zheng X. et al.Evidence for gastrointestinal infection of SARS-CoV-2.Gastroenterology. 2020; 158: 1831-1833.e3Abstract Full Text Full Text PDF PubMed Scopus (2036) Google Scholar,8Gu J. Han B. Wang J. COVID-19: gastrointestinal manifestations and potential fecal-oral transmission.Gastroenterology. 2020; 158: 1518-1519Abstract Full Text Full Text PDF PubMed Scopus (1056) Google Scholar These viral properties should guide the adjustments made to the structure and function of motility laboratories. Ideally, during the outbreak, the laboratory should have characteristics typical of an airborne infection isolation room (ie, single patient at a time, closed door at all times except during entry or exit, negatively pressured with air exhausted to outside or filtered with a high-efficiency particulate air filter). At the outset, patients need to be triaged as suspected, probable, or confirmed COVID-19, as defined by the World Health Organization.9World Health OrganizationGlobal Surveillance for human infection with coronavirus disease (COVID-19).https://www.who.int/publications-detail/global-surveillance-for-human-infection-with-novel-coronavirus-(2019-ncovDate accessed: April 17, 2020Google Scholar The waiting area should have safe distancing measures in place, with a recommended distance between patients of 1 m. Procedure rooms should be cleaned and disinfected regularly before and after routine use. Reusable laboratory inventory such as HRM catheters should be promptly cleaned and disinfected after use as per manufacturer recommendations and institution guidelines. All disposable items (eg, pH/pH impedance catheters) should not be reused and must be promptly and safely disposed after the procedure. Personal protective equipment (PPE) similar to that recommended for upper endoscopy is reasonable for esophageal physiologic testing.10Sultan S. Lim J.K. Altayar O. et al.AGA Institute rapid recommendations for gastrointestinal procedures during the COVID-19 pandemic.Gastroenterology. 2020 Mar 31; ([E-pub ahead of print])Abstract Full Text Full Text PDF Scopus (237) Google Scholar While this may vary by region, appropriate PPE consists at least of a fluid repellent surgical or N95 mask, full arm-length disposable apron, eye protection, and nonsterile single or double gloves for patients not suspected to have COVID-19, but recommendations have potential to change as insights into disease spread further develop.11Repici A. Pace F. Gabbiadini R. et al.Endoscopy units and the COVID-19 outbreak: a multi-center experience from Italy.Gastroenterology. 2020 Apr 10; ([E-pub ahead of print])Abstract Full Text Full Text PDF Scopus (100) Google Scholar Esophageal manometry should not be performed in highly suspect symptomatic or COVID-19–positive patients. Both donning and doffing of PPE should be carried out in a proper manner.4Repici A. Maselli R. Colombo M. et al.Coronavirus (COVID-19) outbreak: what the department of endoscopy should know.Gastrointest Endosc. 2020 Mar 14; ([E-pub ahead of print])Abstract Full Text Full Text PDF Scopus (393) Google Scholar Optimally, only 1 staff member should interact with the patient and perform the procedure. Prior to nasal intubation, additional protective measures may be applicable including the use of virucidal povidone-iodine 7% gargle or mouthwash.7Xiao F. Tang M. Zheng X. et al.Evidence for gastrointestinal infection of SARS-CoV-2.Gastroenterology. 2020; 158: 1831-1833.e3Abstract Full Text Full Text PDF PubMed Scopus (2036) Google Scholar After the procedure, the procedure area should be thoroughly cleaned and disinfected before the next patient is brought in. Many of the previous recommendations are not evidence-based, but rather are solely reliant on limited available data related to endoscopy, interpreted within the framework of our experience. While we have not specifically discussed anorectal motility studies, these recommendations would also apply, especially because fecal transmission remains a risk.8Gu J. Han B. Wang J. COVID-19: gastrointestinal manifestations and potential fecal-oral transmission.Gastroenterology. 2020; 158: 1518-1519Abstract Full Text Full Text PDF PubMed Scopus (1056) Google Scholar As the acute crisis resolves and motility laboratories open back up for business, we suggest that emergent and urgent procedures are given priority, followed by semiurgent procedures, and finally elective procedures. Of course, how and when reopening will occur remains unknown, and must be adapted to the local context. We hope that more detailed recommendations will become available in the near future from respective specialty societies to guide practitioners not only during, but also following the pandemic.