tbuckley/cabot-search huggingface dataset:
Drug treatment (tx) patterns and survival among patients (pts) with metastatic or recurrent soft tissue sarcoma (m/rSTS) refractory to at least one prior therapy.
Authors: Michael Wagner, Leo Amodu, Mei Sheng Duh, Caroline Korves, Franco Solleza, Andrew Mykletun, Stephanie Manson, Jose Diaz, Maureen P. Neery, George D. Demetri
Journal: Journal of Clinical Oncology (2012)

10061 Background: Limited clinical data on real-world practice patterns are available for care of pts with m/rSTS. This study evaluated drug tx patterns and outcomes in m/rSTS pts following failure of prior chemotherapy based on data from a U.S. referral academic cancer center. Methods: Data from medical records consented for research use were retrospectively reviewed at Dana-Farber Cancer Institute for pts with m/rSTS who were ≥18 years, commenced 2nd-line systemic therapy between 1/1/2000 and 2/4/2011, had confirmed disease progression on or after 1st-line therapy and had ≥3 months of observation. Pts were excluded if they had been diagnosed with gastrointestinal stromal tumor, bone sarcoma or dermatofibrosarcoma protuberans, or had ever been treated with pazopanib. Histologic subtype, tx type and duration, tx modifications (e.g., discontinuation) and reasons for modifications were examined. Overall survival, time to progression and clinician-assessed tumor response were collected. Results: Study pts had leiomyosarcoma (n=50), synovial cell sarcoma (n=7), liposarcoma (n=5) and other histologic subtypes (n=39). These 101 pts received an average 4 lines of tx (maximum=10 lines). Wide variations were noted in each line of tx (Table) with no consistent nor dominant regimens. Median 2nd-line tx duration was 4.1 months (95%CI 2.9-5.0). Among 98 pts who discontinued 2nd-line tx, 72 (73%) did so due to progressive disease, 10 due to “completion” of planned tx, and 6 to adverse events. Median progression-free survival from initiation of 2nd-line tx varied across regimens from 2.0 to 6.5 months (overall median 5.5 months). Conclusions: The wide variation in ≥2nd-line tx confirms there is no single “standard” of care for m/rSTS. The majority of pts discontinued 2nd-line tx due to progressive disease and often received additional lines of tx, indicating frequent physician and pt switching of tx. [Table: see text]
SAT0674 ADIPOKINES AND ENDOTHELIAL DYSFUNCTION IN SYSTEMIC LUPUS ERYTHEMATOSUS
Authors: Ahmed Yamany, Mervat Behiry, Ahmed Fayed, Ahmed Soliman
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> Premature atherosclerosis is clearly described in systemic lupus erythematosus as a main cause of poor outcomes and mortality(1).Pleiotropic adipokines including adiponectin and visfatin are implicated in the inflammatory process of lupus disease that promote cytokines signaling leading accelerated endothelial disruption(2) <h3>Objectives</h3> To evaluate the endothelial dysfunction by measuring serum visfatin,adiponectin,leptin and HOMA-insulin Index as reliable biomarkers of atherosclerosis &amp;estimating the FMD of brachial artery among lupus patients and correlating these parameters with clinical characteristics <h3>Methods</h3> A case-control study in which 150 systemic lupus patients who were fulfilling American College of Rheumatology revised classification were recruited consecutively from Internal Medicine department at Cairo University.They were compared to 90 age &amp; sex matched healthy controls. Patients who were pregnant,smoker,diabetic,those with hepatic and renal dysfunction, hypothyroidism,and familial dyslipidemia were excluded.Adiponectin,leptin,visfatin and HOMAIR were evaluated.Flow mediated dilatation of brachial artery was calculated as the maximum percent increase in artery diameter after cuff release compared to baseline <h3>Results</h3> Data revealed elevated levels of adiponectin,leptin,visfatin and HOMAIR in lupus cases compared to controls with reduced FMD percent.Clinical and laboratory background are summarized in table(1) Table(1) None of adipokines is correlated to age,BMI,Disease duration or activity.An inverse correlation between FMD of the brachial artery and total cholesterol, visfatin, adiponectin, leptin and HOMAIR (r-value=-0.523,- 0.35,-0.27,-0.45,-0.56 respectively)with P&lt;0.05.Adipokines and FMD did not differ regarding clinical presentations specially cardiovascular.Roc curve analyses studied the performance of adipokines.Adiponectin and visfatin are better to predict reduced FMD.Table(2) <h3>Conclusion</h3> Endothelial dysfunction is evident in SLE.Reduced FMD of brachial artery and increased adipokines &amp;HOMAIR are noted.Adiponectin and visfatin could be predictors of atherosclerosis in lupus <h3>References</h3> [1] Nassef S, Essam M, Abdelfattah D, et al. Evaluation of Impact of Interferon-Induced Helicase C Domain-Containing Protein 1 Gene in Egyptian Systemic Lupus Erythematosus Patients and its Relationship With Vascular Manifestations of the Disease. Arch Rheumatol 2018;33(2):181–9. [2] Li H, Zhang T, Leng R, Li X. Emerging role of adipokines in systemic lupus erythematosus. Immunol Res. 2016;64(4):820–30. <h3>Acknowledgement</h3> to all participants in this work <h3>Disclosure of Interests</h3> None declared
Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection
Authors: William H. Hudson, Julia Gensheimer, Masao Hashimoto, Andreas Wieland, Rajesh M. Valanparambil, Peng Li, Jian-Xin Lin, Bogumila T. Konieczny, Se Jin Im, Gordon J. Freeman, Warren J. Leonard, Haydn T. Kissick, Rafi Ahmed
Journal: Immunity (2019)
Abstract 14245: Heart Re-Transplant Recipients Fare Better with Concurrent Kidney Transplantation than with Heart Re-Transplant Alone
Authors: Kimberly Y Lin, Madhura Pradhan, Rebecca Ruebner, Somaly Srey, Robert Shaddy, Beth Kaufman, Peter Abt, J. William Gaynor, Joseph W Rossano
Journal: Circulation (2012)

Introduction: Heart re-transplant (HRT) recipients comprise an increasing proportion of heart transplant recipients. Such patients have an increased burden of comorbidities including kidney disease...
Clinical Outcome of Chronic Lymphocytic Leukemia Patients with Sole 13q FISH Detectable Defects: One Versus Two 13q Deletions.
Authors: Daniel L. Van Dyke, Tait D. Shanafelt, Timothy G. Call, Clive S. Zent, Stephanie A. Smoley, Kari G. Rabe, Susan M. Schwager, Jessica C. Sonbert, Neil E. Kay
Journal: Blood (2008)
New government is urged not to stoke “unrealistic expectations” about NHS performance
Authors: Gareth Iacobucci
Journal: BMJ (2019)

The next UK government must be honest with the public about the health and care improvements it can credibly deliver given the huge pressures facing the service, experts have urged.

In a podcast recorded for The BMJ at the King’s Fund ahead of the UK general election1 a panel of experts highlighted that, despite the sizeable cash injection the NHS received this year in the NHS long term plan, the service was still in poor financial health.

With the NHS grappling with chronic staffing shortages, increasing demand, and constrained funding, the panel warned politicians that their promised extra investment might not …
Outbreak of invasive pneumococcal disease among shipyard workers, Turku, Finland, May to November 2019
Authors: Marius Linkevicius, Veronica Cristea, Lotta Siira, Henna Mäkelä, Maija Toropainen, Marjaana Pitkäpaasi, Timothee Dub, Hanna Nohynek, Taneli Puumalainen, Esa Rintala, Merja E. Laaksonen, Thijs Feuth, Juha O. Grönroos, Jutta Peltoniemi, Heikki Frilander, Irmeli Lindström, Jussi Sane
Journal: Eurosurveillance (2019)

We report an outbreak of invasive pneumococcal disease and pneumococcal pneumonia among shipyard workers, in Turku, Southwest Finland. In total, 31 confirmed and six probable cases were identified between 3 May and 28 November 2019. Streptococcus pneumoniae serotypes 12F, 4 and 8 were isolated from blood cultures of 25 cases. Occupational hygiene measures and vaccination of ca 4,000 workers are underway to control the outbreak at the shipyard.
Defibrotide (DF) for the Treatment of Veno-Occlusive Disease (VOD) and Multi-System Organ Failure (MOF) Post SCT: Analysis of Response and Survival According to Degree and Type of MOF.
Authors: Paul G. Richardson, R. J. Soiffer, J. H. Antin, Z. Jin, J. Kurtzberg, P. L. Martin, D. Hockenbery, K. F. Murray, G. B. Vogelsang, A. Chen, A. Krishnan, N. A. Kernan, D. Avigan, T. R. Spitzer, D. Warren, P. Momtaz, C. Revta, L. J. Wei, M. Iacobelli, G. B. McDonald, E. C. Guinan
Journal: Blood (2005)
以工作为基础的学习——bmjlearning．com
Authors: 许群, 乌正赉
Journal: BMJ (2005)

过去医学生和医生大部分都是在课堂上学习，然后参加考试或其他形式的正式评估。一旦取得学位或证书时，他们的学习就到达一个终点。多数医生认为这是“适宜的学习”，而所有其他学习形式多少有点与标准不符。
Premature mortality attributable to socioeconomic inequality in England between 2003 and 2018: an observational study
Authors: Dan Lewer, Wikum Jayatunga, Robert W Aldridge, Chantal Edge, Michael Marmot, Alistair Story, Andrew Hayward
Journal: The Lancet Public Health (2019)

Low socioeconomic position is consistently associated with increased risk of premature death. The aim of this study is to measure the aggregate scale of inequality in premature mortality for the whole population of England.
Incision and snaring: a simple trick to grasp flat colonic lesions
Authors: Benedetto Mangiavillano, Francesco Auriemma, Mario Bianchetti, Roberta Maselli, Alessia Galtieri, Alessandro Repici
Journal: Endoscopy (2019)

Endoscopic mucosal resection (EMR) is, nowadays, a well-standardized therapeutic technique for the treatment of gastrointestinal (GI) neoplasm limited to the mucosal layer. EMR is indicated for the removal of sessile or flat polyps smaller than 2 cm or for piecemeal removal of larger lesions [1]. Compared with EMR, endoscopic submucosal dissection (ESD) results in a higher en bloc resection rate and lower local recurrence rate, yet ESD has high procedure-related complication rates and is more time-consuming [2]. Especially in presence of flat lesions, grasping the lesions can be challenging. A hybrid technique solved this problem, although it is also a time-consuming procedure [3]. When sessile or flat lesions can be removed by EMR, one simple trick for grasping the lesion is, after submucosal injection, to create an incision in the normal mucosa in the fold beyond the proximal edge of the lesion where the tip of the snare will be inserted. Afterwards the scope is withdrawn slowly until the snare is completely open. Then the lesion can be grasped, deflating the bowel, and cut ([Video 1]).
Combination chemotherapy with irinotecan and cisplatin (IP) for advanced large-cell neuroendocrine carcinoma (LCNEC) of the lung: A multicenter phase II study.
Authors: Seiji Niho, Hirotsugu Kenmotsu, Ikuo Sekine, Genichiro Ishii, Yuichi Ishikawa, Masayuki Noguchi, Fumihiro Oshita, Shun-ichi Watanabe, Ryu Nakajima, Hirohito Tada, Kanji Nagai
Journal: Journal of Clinical Oncology (2013)

8037 Background: LCNEC and small cell lung cancer (SCLC) are recognized as high-grade neuroendocrine carcinoma of the lung. A differential diagnosis between LCNEC and SCLC using a tiny biopsy specimen is frequently difficult. Consequently, prospective clinical trials examining chemotherapy for advanced LCNEC have seldom been reported. We conducted a phase II study of combination chemotherapy with IP in patients (pts) with advanced LCNEC. Methods: The eligibility criteria included a chemotherapy-naïve status, a histological diagnosis of advanced LCNEC, an age of 20-75 years, and an ECOG PS of 0-1. Pts received I (60 mg/m 2 , days 1, 8, and 15) and P (60 mg/m 2 , day 1) every 4 weeks for up to 4 cycles. The primary endpoint was the response rate (RR). The sample size was determined to be 44, with a one-sided alpha of 0.1, a beta of 0.2, and expected and threshold values for the primary endpoint of 50% and 30%. Results: 44 pts from 11 institutes were enrolled between Jan 2005 and Nov 2011. The median age was 62.5 years; 21 pts had a PS of 0, and 35 pts were male. 5 pts had stage IIIB, 28 had stage IV, and 11 had recurrences after surgical resection. The RR was 54.5% (95% CI, 38.8-69.6). Grade 3 or 4 neutropenia was observed in 24 pts, but only 3 pts experienced febrile neutropenia. Other toxicities were mild and manageable. The median progression-free survival (PFS) was 5.9 months (95%CI, 5.5-6.3), and the median survival time (MST) was 15.1 months (95%CI, 11.2-19.0). Pathological specimens for a pre-planned central review were available for 41 pts. 30 pts were diagnosed as having LCNEC, whereas 10 pts were diagnosed as having SCLC, and 1 patient was diagnosed as having non-SCLC with a neuroendocrine morphology. Subgroup analyses were shown in the Table. Conclusions: Combination chemotherapy with IP was active in pts with advanced LCNEC, but the RR and the overall survival period in pts with LCNEC seemed to be inferior to those in pts with SCLC. Clinical trial information: UMIN000004796. [Table: see text]
Bcr-Abl Inhibitors Induce Expression of HoxA10, Playing a Role as an Inhibitor of the Proliferation through PI3K/PKB Pathway in Chronic Myelogenous Leukemia Cells.
Authors: Yuya Sugimoto, Satoki Nakamura, Takaaki Ono, Miki Kobayashi, Naohi Sahara, Kaori Shinjo, Kazuyuki Shigeno, Kazunori Ohnishi
Journal: Blood (2006)
Probiotic bacteria as modulators of cellular senescence: emerging concepts and opportunities
Authors: Rohit Sharma, Yogendra Padwad
Journal: Gut Microbes (2019)

Probiotic bacteria are increasingly gaining importance in human nutrition owing to their multifaceted health beneficial effects. Studies have also shown that probiotic supplementation is useful in mitigating age-associated oxi-inflammatory stress, immunosenescence, and gut dysbiosis thereby promoting health and longevity. However, our current understanding of the process of aging suggests a strong interrelationship between the accumulation of senescent cells and the development of aging phenotype, including the predisposition to age-related disorders. The present review studies the documented pro-longevity effects of probiotics and highlights how these beneficial attributes of probiotics could be related to the mitigation of cellular senescence. We present a perspective that to fully understand and comprehend the anti-aging characteristics of probiotic bacteria; it is imperative that probiotics or their synbiotic amalgamation with plant polyphenols, be studied under the purview of cellular senescence, that may ultimately help devise probiotic-based anti-senescence strategies.
VACStent: a new option for endoscopic vacuum therapy in patients with esophageal anastomotic leaks after upper gastrointestinal surgery
Authors: Seung-Hun Chon, Isabel Bartella, Martin Bürger, Isabel Rieck, Tobias Goeser, Wolfgang Schröder, Christiane Josephine Bruns
Journal: Endoscopy (2019)

Esophageal anastomotic leaks remain a life-threatening postoperative complication of upper gastrointestinal surgery. In Germany, self-expandable metal stents (SEMS) and endoscopic vacuum therapy (EVT) are established endoscopic treatment options [1] [2], but no evidence points to the superiority of either of these [3]. Consequently, new approaches aim to combine both procedures [4] [5].
Abstract 12583: The Predictive Utility of Circulating C-Type Natriuretic Peptide for Myocardial Infarction and Heart Failure in the General Population
Authors: S. J Sangaralingham, Paul M McKie, Tomoko Ichiki, Christopher G Scott, Denise M Heublein, Horng H Chen, Richard J Rodeheffer, John C Burnett
Journal: Circulation (2013)

Background: C-type natriuretic peptide (CNP) is an endothelial cell derived 22 amino acid peptide. Previous studies have reported that CNP is a coronary vasodilator as well as possesses anti-athero...
Abstract 16896: Exercise Pulmonary Capillary Wedge Pressure Patterns in Patients With Normal Resting Left-sided Filling Pressures Predict Heart Failure Outcomes
Authors: Aaron S Eisman, Ravi V Shah, Bishnu P Dhakal, Stephanie M Meller, Paul P Pappagianopoulos, Ashley E Dress, Rajeev Malhotra, Rory B Weiner, Aaron L Baggish, Gregory D Lewis
Journal: Circulation (2015)

Introduction: Serial measurements of pulmonary capillary wedge pressure (PCWP) during exercise testing may help to improve hemodynamic (HD) classification of heart failure with preserved ejection fraction (HFpEF). However, the physiologic and prognostic significance of exercise PCWP patterns is largely unknown. Hypothesis: An elevated PCWP increment relative to cardiac output (CO) augmentation during exercise will independently predict exercise capacity and outcomes in patients with dyspnea on exertion and normal resting PCWP (DOE-nlrW). Methods: In a single center cohort of 175 patients referred for cardiopulmonary exercise testing (CPET) with invasive HD monitoring (n = 33 normal controls, n = 32 HFpEF with resting PCWP ≥ 15, and n = 110 consecutive patients with DOE-nlrW and LVEF &gt; 0.45) 1,929 PCWP-CO points during exercise were measured. Median follow-up was 3.2 years and events consisted of HF hospitalization, CV death, or future RHC with resting PCWP ≥ 15 mmHg. Results: PCWP-CO slope of 1.2±0.4 mmHg/L/min in controls was used to establish the upper limit (mean + 2SDev) of normal of 2mmHg/L/min. HFpEF patients had a PCWP-CO slope of 3.6±1.8 mmHg/L/min. In the DOE-nlrW cohort, patients achieved a mean peak VO2 of 17±6 ml/kg/min (74±19 % predicted), mean PCWP-CO was 2.1±1.3 mmHg/L/min (Figure) with 45 of 110 patients having elevated PCWP-CO. PCWP-CO but not resting PCWP was related to peak VO2 in univariable (rho = -0.51, p &lt; 0.01) and multi-variable linear regression adjusted for age, sex, hypertension, beta blocker use, diabetes, and resting PCWP (ß = -0.17, p = 0.03). Increased PCWP-CO also predicted worse event-free survival in univariable Cox regression (HR 1.67, p &lt; 0.01) and after adjustment for age, sex, BMI, and resting PCWP (HR 1.56, p = 0.03). Conclusions: Elevated PCWP-CO during exercise ( &gt; 2mmHg/L/min) is common in DOE-nlrW and predicts exercise capacity as well as outcomes, suggesting that assessment of exercise HD may help to refine early HFpEF diagnosis.
Phase II Clinical Study of Bortezomib (VELCADE®) in Patients (pts) with Relapsed / Refractory Non-Hodgkin’s Lymphoma (NHL) and Hodgkin’s Disease (HD).
Authors: Sandra J. Strauss, Lenushka Maharaj, Jim Stec, Anthony Boral, Elizabeth Trehu, David Schenkein, Simon P. Joel, T. Andrew Lister
Journal: Blood (2004)
Active Oral Regimen for Elderly Adults with Newly Diagnosed Acute Myelogenous Leukemia (AML): Phase I Trial of Oral Tipifarnib (T) Combined with Oral Etoposide (E) for Adults ≥Age 70 Who Are Not Candidates for Traditional Cytotoxic Chemotherapy (TCC).
Authors: Judith E. Karp, Eric J. Feldman, Lawrence Morris, Jacqueline Greer, Valerie Ironside, B. Douglas Smith, Ellen Ritchie, Steven D. Gore, Mark J. Levis, Scott H. Kaufmann, Sami Malek, John J. Wright
Journal: Blood (2006)
Examination of the early learning curve for transcatheter closure of patent ductus arteriosus using the rashkind occluder
Authors: D. T. Gray, A. M. Walker, D. C. Fyler, T. C. Chalmers
Journal: Circulation (1994)

background Results of transcatheter implantation of the Rashkind double umbrella occluder for treatment of patent ductus arteriosus (PDA) have improved over time. We evaluated factors associated with changes in outcomes seen in the early clinical experience with this device. Methods and Results We reviewed records of otherwise healthy pediatric patients undergoing occluder implantation for isolated PDA between 1982 and 1987 at six major US and Canadian referral centers. Logistic regression was used to assess the impact of ductal size, patient age and weight, calendar time, prior intrainstitutional occluder experience, and residual center effects on closure rates. There were no study deaths
Pro-Oxidative and Proinflammatory Effects After Traveling From Los Angeles to Beijing
Authors: Yan Lin, Gajalakshmi Ramanathan, Yifang Zhu, Fen Yin, Nolan D. Rea, Xinchen Lu, Chi-Hong Tseng, Kym F. Faull, Alexander J. Yoon, Michael Jerrett, Tong Zhu, Xinghua Qiu, Jesus A. Araujo
Journal: Circulation (2019)

Exposure to air pollution increases cardiovascular morbidity and mortality. Preventing chronic cardiovascular diseases caused by air pollution relies on detecting the early effects of pollutants on the risk of cardiovascular disease development, which is limited by the lack of sensitive biomarkers. We have previously identified promising biomarkers in experimental animals but comparable evidence in humans is lacking.Air pollution is substantially worse in Beijing than in Los Angeles. We collected urine and blood samples from 26 nonsmoking, healthy adult residents of Los Angeles (mean age, 23.8 years; 14 women) before, during, and after spending 10 weeks in Beijing during the summers of 2014 and 2015. We assessed a panel of circulating biomarkers indicative of lipid peroxidation and inflammation. Personal exposure to polycyclic aromatic hydrocarbons (PAHs), a group of combustion-originated air pollutants, was assessed by urinary PAH metabolite levels.Urinary concentrations of 4 PAH metabolites were 176% (95% CI, 103% to 276%) to 800% (95% CI, 509% to 1780%) greater in Beijing than in Los Angeles. Concentrations of 6 lipid peroxidation biomarkers were also increased in Beijing, among which 5-, 12-, and 15-hydroxyeicosatetraenoic acid and 9- and 13-hydroxyoctadecadienoic acid levels reached statistical significance (false discovery rate <5%), but not 8-isoprostane (20.8%; 95% CI, -5.0% to 53.6%). The antioxidative activities of paraoxonase (-9.8%; 95% CI, -14.0% to -5.3%) and arylesterase (-14.5%; 95% CI, -22.3% to -5.8%) were lower and proinflammatory C-reactive protein (101%; 95% CI, 3.3% to 291%) and fibrinogen (48.3%; 95% CI, 4.9% to 110%) concentrations were higher in Beijing. Changes in all these biomarkers were reversed, at least partially, after study participants returned to Los Angeles. Changes in most outcomes were associated with urinary PAH metabolites (P<0.05).Traveling from a less-polluted to a more-polluted city induces systemic pro-oxidative and proinflammatory effects. Changes in the levels of 5-, 12-, and 15-hydroxyeicosatetraenoic acid and 9- and 13-hydroxyoctadecadienoic acid as well as paraoxonase and arylesterase activities in the blood, in association with exposures to PAH metabolites, might have important implications in preventive medicine as indicators of increased cardiovascular risk caused by air pollution exposure.
進行非小細胞肺癌(NSCLC)における少量の生検材料を用いた全ゲノム増幅法によるEGFR、K-ras、p53およびc-MET遺伝子変異の予後因子としての評価
Authors: Elaine H. Lim
Journal: Journal of Thoracic Oncology (2009)