tbuckley/cabot-search huggingface dataset:
Microvascular Disease in Chronic Thromboembolic Pulmonary Hypertension
Authors: Christian Gerges, Mario Gerges, Richard Friewald, Pierre Fesler, Peter Dorfmüller, Smriti Sharma, Kristof Karlocai, Nika Skoro-Sajer, Johannes Jakowitsch, Bernhard Moser, Shahrokh Taghavi, Walter Klepetko, Irene M. Lang
Journal: Circulation (2020)

Background: Pulmonary endarterectomy (PEA) is the gold standard treatment for patients with operable chronic thromboembolic pulmonary hypertension. However, persistent pulmonary hypertension (PH) after PEA remains a major determinant of poor prognosis. A concomitant small-vessel arteriopathy in addition to major pulmonary artery obstruction has been suggested to play an important role in the development of persistent PH and survival after PEA. One of the greatest unmet needs in the current preoperative evaluation is to assess the presence and severity of small-vessel arteriopathy. Using the pulmonary artery occlusion technique, we sought to assess the presence and degree of small-vessel disease in patients with chronic thromboembolic pulmonary hypertension undergoing PEA to predict postoperative outcome before surgery. Methods: Based on pulmonary artery occlusion waveforms yielding an estimate of the effective capillary pressure, we partitioned pulmonary vascular resistance in larger arterial (upstream resistance [R up ]) and small arterial plus venous components (downstream resistance) in 90 patients before PEA. For validation, lung wedge biopsies were taken from nonobstructed and obstructed lung territories during PEA in 49 cases. Biopsy sites were chosen according to the pulmonary angiogram still frames that were mounted in the operating room. All vessels per specimen were measured in each patient. Percent media (%MT; arteries) and intima thickness (%IT; arteries, veins, and indeterminate vessels) were calculated relative to external vessel diameter. Results: Decreased R up was an independent predictor of persistent PH (odds ratio per 10%, 0.40 [95% CI, 0.23–0.69]; P =0.001) and survival (hazard ratio per 10%, 0.03 [95% CI, 0.00–0.33]; p =0.004). Arterial %MT and %IT of nonobstructed lung territories and venous %IT of obstructed lung territories were significantly increased in patients with persistent PH and nonsurvivors. R up correlated inversely with %MT ( r =–0.72, P &lt;0.001) and %IT ( r =–0.62, P &lt;0.001) of arteries from nonobstructed lung territories and with %IT ( r =–0.44, P =0.024) of veins from obstructed lung territories. Receiver operating characteristic analysis disclosed that R up &lt;66% predicted persistent PH after PEA, whereas R up &lt;60% identified patients with poor prognosis after PEA. Conclusions: Pulmonary artery occlusion waveform analysis with estimation of R up seems to be a valuable technique for assessing the degree of small-vessel disease and postoperative outcome after PEA in chronic thromboembolic pulmonary hypertension.
Phospholipase c beta 1b Depletes Sarcoplasmic Reticulum Calcium Content and Causes Cardiac Contractile Dysfunction
Authors: David R Grubb, Gillian Y Ma, Jieting Luo, Nicola Cooley, Hongwei Qian, Helen Kiriazis, Xiao-Ming Gao, Paul Gregorevic, Xiao-Jun Du, Elizabeth A Woodcock
Journal: Circulation (2013)
<i>JAMA Psychiatry</i>: Best of 2019
Authors: Charles F. Zorumski
Journal: JAMA Psychiatry (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Association Between Maternal Fluoride Exposure and Child IQ
Authors: Declan Waugh
Journal: JAMA Pediatrics (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Pathogen Genomics in Public Health
Authors: Gregory L. Armstrong, Duncan R. MacCannell, Jill Taylor, Heather A. Carleton, Elizabeth B. Neuhaus, Richard S. Bradbury, James E. Posey, Marta Gwinn
Journal: New England Journal of Medicine (2019)

Rapid advances in DNA sequencing technology (“next-generation sequencing”) have inspired optimism about the potential of human genomics for “precision medicine.” Meanwhile, pathogen genomics is already delivering “precision public health” through more effective investigations of outbreaks of foodborne illnesses, better-targeted tuberculosis control, and more timely and granular influenza surveillance to inform the selection of vaccine strains. In this article, we describe how public health agencies have been adopting pathogen genomics to improve their effectiveness in almost all domains of infectious disease. This momentum is likely to continue, given the ongoing development in sequencing and sequencing-related technologies.
CD147 deficiency in T cells prevents thymic involution by inhibiting the EMT process in TECs in the presence of TGFβ
Authors: Ruo Chen, Ke Wang, Zhuan Feng, Ming-Yang Zhang, Jiao Wu, Jie-Jie Geng, Zhi-Nan Chen
Journal: Cellular and Molecular Immunology (2020)

Abstract Thymic involution during aging is a major cause of decreased T-cell production and reduced immunity. Here, we show that the loss of CD147 on T cells prevents thymic senescence, resulting in slowed shrinkage of the thymus with age and increased production of naive T cells. This phenotype is the result of slowing of the epithelial–mesenchymal transition (EMT) process in thymic epithelial cells (TECs), which eventually leads to reduced adipocyte accumulation. In an in vitro coculture system, we found that TGFβ is an important factor in the EMT process in TECs and that it can reduce the expression of E-cadherin through p-Smad2/FoxC2 signaling. Moreover, CD147 on T cells can accelerate the decline in E-cadherin expression by interacting with Annexin A2 on TECs. In the presence of TGFβ, Annexin A2 and E-cadherin colocalize on TECs. However, CD147 on T cells competitively binds to Annexin A2 on TECs, leading to the isolation of E-cadherin. Then, the isolated E-cadherin is easily phosphorylated by phosphorylated Src kinase, the phosphorylation of which was induced by TGFβ, and finally, p-E-cadherin is degraded. Thus, in the thymus, the interaction between T cells and TECs contributes to thymic involution with age. In this study, we illuminate the mechanism underlying the triggering of the EMT process in TECs and show that inhibiting TGFβ and/or CD147 may serve as a strategy to hinder age-related thymic involution.
Cognitive control constrains memory attributions
Authors: Colleen M Kelley, Larry L Jacoby
Journal: Behavioral and Brain Sciences (2019)

Cognitive control constrains retrieval processing and so restricts what comes to mind as input to the attribution system. We review evidence that older adults, patients with Alzheimer's disease, and people with traumatic brain injury exert less cognitive control during retrieval, and so are susceptible to memory misattributions in the form of dramatic levels of false remembering.
Molecular profiling of patients with non-small cell lung cancer (NSCLC) using bronchoscopic ultra-micro sampling.
Authors: Yuichi Sakairi, Sakae Itoga, Kenichi Sato, Kazuyuki Matsushita, Shigetoshi Yoshida, Yuichi Takiguchi, Fumio Nomura, Ichiro Yoshino
Journal: Journal of Clinical Oncology (2012)

7046 Background: Genetic information is essential for molecular targeted therapy for personalized medicine, although tissue sampling for genetic analysis remains challenging. In this study, we investigated the utility of bronchoscopic ultra-micro samples compared with conventional histological materials for multiple gene analyses for NSCLC. Methods: Patients with NSCLC proven by on-site cytological examinations during bronchoscopic survey were eligible. Following conventional needle aspiration biopsy by flexible bronchofiberscope (from primary lesion) or convex probe endobronchial ultrasound (from lymph nodes), the used needle was rinsed with 20 ml of saline and this ultra-micro sample (MS) was used for both cytological diagnosis and genetic analysis. DNA and RNA were extracted from each sample. Gene mutations [EGFR (epidermal growth factor receptor), K-ras, BRAF] and anaplastic lymphoma kinase (ALK) fusion genes were examined by high resolution melting analysis and direct sequencing. The results of cytological diagnoses and gene profiles using MS were compared to conventional histological diagnoses. Results: A total of 79 lesions (30 primary and 49 metastatic nodes) from 76 patients were eligible. Adenocarcinoma (N = 46), squamous cell carcinoma (N = 25), and NSCLC (N = 8) were pathologically confirmed in histological lesion cores; however, only 29 malignancies (37%) were detected with MS. DNA and RNA could be extracted from all histological samples and MS. In 35 cases, genetic disorders were identified, including EGFR mutations (N = 12), K-ras mutations (N = 5), BRAF mutation (N = 1), ALK fusion genes (N = 3), and silent mutations (N = 13); these results were identical for both histological samples and MS. Conclusions: Bronchoscopic ultra-micro samples (biopsy needle rinse fluids) are useful for multiple genetic examinations.
Patterns of metastasis and survival in patients with PI3K pathway-driven stage IV squamous cell lung cancers (SQCLC).
Authors: Paul K. Paik, Andre L. Moreira, Lu Wang, Helen H. Won, Adnan Hasanovic, Natasha Rekhtman, Camelia S. Sima, Marc Ladanyi, Michael F. Berger, Mark G. Kris
Journal: Journal of Clinical Oncology (2013)

8022 Background: The majority of actionable drivers in SQCLCs occur in the PI3K (30%) and FGFR1 (20%) pathways. The biologic behaviors and natural histories of these oncogenic subtypes are not well characterized. Methods: As of October 2011, all patients with SQCLCs at MSK have undergone prospective, multiplex testing of their FFPE tumors for FGFR1 amplification (FISH), PIK3CA mutations (Sequenom), PTEN loss (IHC), and PTEN mutations (exon sequencing), among others. Patient characteristics, outcomes, and metastatic sites were identified. Survival probabilities were estimated using the Kaplan-Meier method. Group comparisons were performed with log-rank tests and Cox proportional hazards methods. Results: 68 stage IV SQCLC patients were analyzed. 39 had tissue sufficient for next-gen sequencing. Genotypes were: FGFR1 amplified (16%); PTEN loss (24%), PIK3CA mutant (7%), PTEN mutant (13%). Events were non-overlapping save for 2 cases with PTENnonsense mutations and PTEN loss. The sole significant clinical difference (KPS, age, sex, lines of tx) was sex (women in PI3K group 52% vs. in others 23%, p=0.02). Metastatic patterns vs. other are shown in the Table. Median OS for PI3K vs. other: 10mo (95%CI:6.5-14.3) vs. 14mo (95%CI:9.6-36.7), p=0.02. Median OS for FGFR1 vs. others: 19mo (95%CI:9-NR) vs. 10mo (95%CI:6.5-14.3), p=0.3. Multivariate analysis for OS: PI3K vs. other, HR death=2.3 (95%CI:1.1-4.8, p=0.03); Age ≥65, HR=1.3 (95%CI:0.6-2.9, p=0.6); KPS≥70, HR=0.5 (95%CI:0.2-1.7, p=0.3); Male sex, HR=0.7 (95%CI:0.3-1.4, p=0.3). Conclusions: Patients with stage IV PI3K-aberrant SQCLCs have poorer survival compared to other patients with SQCLCs. Brain metastases occurred exclusively in patients with PI3K-aberrant tumors. These data suggest that PI3K pathway activation confers a distinct biology, and that targeting this in SQCLC patients with brain metastases may be an effective therapeutic strategy. [Table: see text]
Salmonella-Driven Polarization of Granuloma Macrophages Antagonizes TNF-Mediated Pathogen Restriction during Persistent Infection
Authors: Trung H.M. Pham, Susan M. Brewer, Teresa Thurston, Liliana M. Massis, Jared Honeycutt, Kyler Lugo, Amanda R. Jacobson, Jose G. Vilches-Moure, Meagan Hamblin, Sophie Helaine, Denise M. Monack
Journal: Cell Host & Microbe (2019)
Vasodilatory Actions of Glucagon-Like Peptide 1 Are Preserved in Skeletal and Cardiac Muscle Microvasculature but Not in Conduit Artery in Obese Humans With Vascular Insulin Resistance
Authors: Nasui Wang, Alvin W.K. Tan, Linda A. Jahn, Lee Hartline, James T. Patrie, Shaoda Lin, Eugene J. Barrett, Kevin W. Aylor, Zhenqi Liu
Journal: Diabetes Care (2019)

OBJECTIVE Obesity is associated with microvascular insulin resistance, which is characterized by impaired insulin-mediated microvascular recruitment. Glucagon-like peptide 1 (GLP-1) recruits skeletal and cardiac muscle microvasculature, and this action is preserved in insulin-resistant rodents. We aimed to examine whether GLP-1 recruits microvasculature and improves the action of insulin in obese humans. RESEARCH DESIGN AND METHODS Fifteen obese adults received intravenous infusion of either saline or GLP-1 (1.2 pmol/kg/min) for 150 min with or without a euglycemic insulin clamp (1 mU/kg/min) superimposed over the last 120 min. Skeletal and cardiac muscle microvascular blood volume (MBV), flow velocity and blood flow, brachial artery diameter and blood flow, and pulse wave velocity (PWV) were determined. RESULTS Insulin failed to change MBV or flow in either skeletal or cardiac muscle, confirming the presence of microvascular insulin resistance. GLP-1 infusion alone increased MBV by ∼30% and ∼40% in skeletal and cardiac muscle, respectively, with no change in flow velocity, leading to a significant increase in microvascular blood flow in both skeletal and cardiac muscle. Superimposition of insulin to GLP-1 infusion did not further increase MBV or flow in either skeletal or cardiac muscle but raised the steady-state glucose infusion rate by ∼20%. Insulin, GLP-1, and GLP-1 + insulin infusion did not alter brachial artery diameter and blood flow or PWV. The vasodilatory actions of GLP-1 are preserved in both skeletal and cardiac muscle microvasculature, which may contribute to improving metabolic insulin responses and cardiovascular outcomes. CONCLUSIONS In obese humans with microvascular insulin resistance, GLP-1’s vasodilatory actions are preserved in both skeletal and cardiac muscle microvasculature, which may contribute to improving metabolic insulin responses and cardiovascular outcomes.
Abstract 240: Smartphone Application to Provide Real-Time Cardiopulmonary Resuscitation Quality Feedback
Authors: Emily Stumpf, Ravi Ambati, Raj Shekhar, Steven Staffa, David Zurakowski, Pranava Sinha
Journal: Circulation (2019)

Introduction: Quality of cardiopulmonary resuscitation (CPR) contributes significantly to morbidity and mortality in both in-hospital and out-of-hospital cardiac arrest. Key parameters that determine the CPR quality are compression rate, compression depth, duration of interruptions, chest recoil factor and respiratory rate. Several studies have demonstrated that real-time audiovisual feedback improves CPR quality in both bystanders and hospital staff. This study aims to develop and validate a smart device (phones and wearable technology) application to provide real-time audiovisual and haptic feedback to optimize CPR quality, by calculating aforementioned chest compression parameters. Hypothesis: A mobile application using acceleration sensor data from smart devices can provide accurate real time CPR quality feedback. Methods: A mobile application was developed to track the compression depth, compression rate and pause duration in real time using the data captured from the on-device accelerometer. The mobile device was placed on an adult manikin’s chest along the midline close to the point of compressions. Data from the application was compared directly to data obtained from a validated clinical standard CPR quality tool. Results: CPR quality parameters were obtained from the app and the standard for 60, 10-second-long sessions. Bland-Altman plot analysis for compression depth showed agreement between the app measurements and standard within +/-3.5mm (Figure 1). The intraclass correlation for agreement in the measurement of compression count was 0.92 (95% CI: 0.88-0.95), indicative of very strong agreement. Conclusions: Smart device (phones and wearable technology) applications using acceleration sensor data can accurately provide real-time CPR quality feedback. With further development and validation they can provide a ubiquitous CPR feedback tool valuable for out of hospital arrests and in under-privileged areas worldwide.
Huntington’s Disease Pathogenesis Is Modified In Vivo by Alfy/Wdfy3 and Selective Macroautophagy
Authors: Leora M. Fox, Kiryung Kim, Christopher W. Johnson, Shawei Chen, Katherine R. Croce, Matheus B. Victor, Evelien Eenjes, Joan R. Bosco, Lisa K. Randolph, Ioannis Dragatsis, Joanna M. Dragich, Andrew S. Yoo, Ai Yamamoto
Journal: Neuron (2019)
Achieving complete remission in CLL patients treated with ibrutinib: clinical significance and predictive factors
Authors: Paolo Strati, Ellen J. Schlette, Luisa M. Solis Soto, Daniela E. Duenas, Mariela Sivina, Ekaterina Kim, Michael J. Keating, William G. Wierda, Alessandra Ferrajoli, Hagop Kantarjian, Zeev Estrov, Nitin Jain, Philip A. Thompson, Ignacio I. Wistuba, Jan A. Burger
Journal: Blood (2020)
Abstract 10004: Prediction of Fat and Fibrotic Invasion in the Left Ventricular Myocardium Using Four-dimensional Cardiac Computed Tomography in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy
Authors: Nobusada Funabashi, Yoshio Kobayashi
Journal: Circulation (2019)

Introduction: Arrhythmogenic right ventricular (RV) cardiomyopathy (ARVC) is a genetic heart muscle disorder with an increased risk of critical ventricular arrhythmias but its prediction is unclear...
Toward a Speech Neuroprosthesis
Authors: Edward F. Chang, Gopala K. Anumanchipalli
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Spectrum, Long-Term Outcomes and Predictors of Relapse after Imatinib Discontinuation in FIP1L1-Pdgfra-Associated Chronic Eosinophilic Leukemia: Data from 150 Patients
Authors: Julien Rohmer, Matthieu Groh, Julie Trichereau, Kewin Panel, Claude Preudhomme, Fanny Legrand, Felix Ackermann, Amélie Couteau-Chardon, Mikael Ebbo, Olivier Fain, Lionel Galicier, Mohamed Hamidou, Mathilde Hunault, Etienne Lengline, Catherine Mohr, Franck E Nicolini, Jerome Rey, Louis Terriou, Chafika Morati Hafsaoui, Suzanne Tavitian, Irene Machelart, Katayoun Jondeau, Bertrand Arnulf, Jean-Christophe Ianotto, Jean-Marc Zini, Viviane Dubruille, Francoise Huguet, Borhane Slama, Fabrice Jardin, Didier Adiko, Elise Toussaint, Aurelien Guffroy, Faustine Lhomme, Nathalie Grardel, Cyrielle Gesquieres, Guillaume Lefèvre, Jean Emmanuel Kahn
Journal: Blood (2019)
Highlighting the Need for Action Regarding Persistent Sex Bias in Research—Reply
Authors: Timothy S. Anderson, Michael A. Steinman
Journal: JAMA Internal Medicine (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal