FRI0195 Clinical characteristics of 897 chinese ankylosing spondylitis/spondyloarthritis real world cohort: data from a chinese cohort with smart management system for spondyloarthritis (SMSP)
Authors: X. Ji, J. Zhu, J. ZHANG, F. Huang
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> With increasing global popularity of smartphone technology, there is a great opportunity for using mobile phone applications for disease management. Smart Management System for Spondyloarthritis (SpA) (SMSP) created a smart management system for SpA using eHealth technologies in China. <h3>Objectives</h3> The aim of this study was to report major characteristics of Chinese ankylosing spondylitis patients derived from a large, longitudinal and prospective database with SMSP. <h3>Methods</h3> SMSP was designated for multicenter, consecutive, and prospective cohorts, including patients’ mobile terminal, the physician workstation system, and communication system. Patients’ portal was used for self-assessment prior visiting clinics, short message consultation, monitoring symptoms between clinic visits as well as uploading/downloading medical records, while physician’ portal was used for professional assessment at clinic, scheduled visits reminder, sending self-management strategies at intervals and making recommendations and delivering patient-specific guidance to the individual. In this preliminary analysis, all patients fulfilled the modified New York criteria. All data were collected online using SMSP. <h3>Results</h3> From April 2016 to June 2017, data were extracted online from the physician workstation system in 4 rheumatology centres across China. There was a total of 2790 times self-assessment of BASDAI, BASFI performed by patients (median times=3.1, from1 to 14) and a total of 1960 evaluation performed by the physician at the clinic (median times=2.1, from 1 to 10). A total of 897 AS patients (mean age: 30.8±8.8 years, male 82.7%, HLA-B27 positive rate 88.0%) were recruited in this baseline analysis. The median disease duration was 7.1 (0.01 to 39.63) years. A history or current symptoms suggestive of acute anterior uveitis, psoriasis, and inflammatory bowel disease were observed in 17.2%, 2.6%, 7.1% of the patients, respectively. Differences in symptom duration (≤5 years, 5 years to 10 years and &gt;10 years) were analysed. Acute anterior uveitis and inflammatory bowel disease were detected significantly more frequently in patients with symptom duration of &gt;10 years (27.0%, 11.0%, respectively), shown in table 1. According to the ASDAS, at the baseline visit, 20.1% of patients achieved inactive disease, 30.8% with moderate disease activity, 37.3% with high disease activity and 10.6% with very high disease activity. The most commonly used medication was NSAIDs (98.9%). The patients using biological DMARDs possessed a percentage of 15.5%. 12.8% of the patients used etanercept which was the most commonly used biological DMARDs. 64.7% of the patients used conventional synthetic DMARDs. <h3>Conclusions</h3> SMSP is an effective mobile interface to serve AS patients performing self-management as well as to supply physicians with valuable and reliable data with a minimal bias for online data collection and automatic quality controls. This large cohort may improve our knowledge of the characteristics, pathogenesis and natural course in Chinese patients with AS. <h3>Disclosure of Interest</h3> None declared