tbuckley/cabot-search huggingface dataset:
Abstract 45: HDAC6 Inhibitor Attenuates Autophagy During Chronic Angiotensin-II Induced Hypertrophic Human Cardiomyocytes
Authors: Sheeja Rajasingh, Andras Czirok, Dona G Isai, Saheli Samanta, Zhigang Zhou, Buddhadeb Dawn, Johnson Rajasingh
Journal: Circulation Research (2017)

Introduction: Autophagy is playing a crucial role in cellular functions, and maintaining homeostasis during cardiac hypertrophy, but the mechanism is poorly understood. Studies have shown that pressure overload and chronic ischemia-induced stress leads to an increase in autophagic activity in cardiomyocytes. Reports have demonstrated that STAT3 and Bcl2 participate in the process of autophagy. We plan to study the possible contribution of epigenetic enzymes that mediate transcriptional repression and activation of genes related to autophagy. Here, we have examined the role of histone deacetylase-6 (HDAC6) inhibitor (Tubastatin A- TBSA) in protecting chronic angiotensin II-induced autophagy in human iPSC-derived cardiomyocytes (hiCMCs). Hypothesis: We hypothesize that TBSA treatment mediated protection is through STAT3-Bcl2 signaling in angiotensin II-induced autophagy in hypertrophic hiCMCs. Methods and Results: We have evaluated the TBSA treatment mediated effects in contractility, cell size and mitochondrial membrane potential ( Δ Ψm) in response to angiotensin II-induced autophagy in hiCMCs. Our immunofluorescence data show that treatment with TBSA significantly reduced the number of autophagosomes in angiotensin II-induced hiCMCs ( Fig. A) . Moreover, the flow cytometry data show the fluorescence intensity ratio of red and green in JC1 staining suggest that TBSA restores and maintains the angiotensin II-induced loss of Δ Ψm in hiCMCs ( Fig B, C ). Conclusions: We report for the first time that the role of HDAC6 in regulation of pathological autophagy, thus can acts as a potential therapeutic target for treatment of chronic heart diseases.
The bigger picture
Authors: Sarah Bache
Journal: BMJ (2006)

It was a cold and dreary December night. I was heading back from the library yet again, with a pile of notes in my bag and a head crammed full of facts. Mid revision for fourth year exams is a sobering place to be and I began to wonder why I was there. Was the choice I made six years ago to do medicine still the right one for me? I felt like I needed to step back and think about it. It was then that I decided to organise my seven week option module to do something completely different. …
Abstract 15857: Distance-temperature Relationship and Acute/Chronic Complications of a Novel Linear Cryo Ablation Catheter in Comparison With 2nd Generation Cryoballoon Catheter in a Canine Model
Authors: Atsushi Suzuki, H. Immo Lehmann, Songyun Wang, Kay D Parker, Maryam E Rettmann, Douglas L Packer
Journal: Circulation (2017)

Introduction: A novel linear cryo ablation catheter (LC) for continuous linear lesion creation has been developed. Skepticism about effectiveness of LC has arisen from a lack of comparison with the...
Evaluation of a Peer-to-Peer Data Transparency Intervention for Mohs Micrographic Surgery Overuse
Authors: John G. Albertini, Peiqi Wang, Christine Fahim, Susan Hutfless, Thomas Stasko, Allison T. Vidimos, Barry Leshin, Elizabeth M. Billingsley, Brett M. Coldiron, Richard G. Bennett, Victor J. Marks, Angela Park, Heidi N. Overton, William E. Bruhn, Tim Xu, Aravind Krishnan, Martin A. Makary
Journal: JAMA Dermatology (2019)

Mohs micrographic surgery (MMS) is a skin cancer treatment that uses staged excisions based on margin status. Wide surgeon-level variation exists in the mean number of staged resections used to treat a tumor, resulting in a cost disparity and question of appropriateness.To evaluate the effectiveness of a behavioral intervention aimed at reducing extreme overuse in MMS, as defined by the specialty society, by confidentially sharing stages-per-case performance data with individual surgeons benchmarked to their peers nationally.This nonrandomized controlled intervention study included 2329 US surgeons who performed MMS procedures from January 1, 2016, to March 31, 2018. Physicians were identified using a 100% capture of Medicare Part B claims. The intervention group included physicians affiliated with the American College of Mohs Surgery, and the control group included physicians not affiliated with the American College of Mohs Surgery.Individualized performance reports were delivered to all outlier surgeons, defined by the specialty society as those with mean stages per case 2 SDs above the mean, and inlier surgeons in the intervention group.The primary outcome was surgeon-level change in mean stages per case between the prenotification (January 2016 to January 2017) and postnotification (March 2017 to March 2018) periods. A multivariable linear regression model was used to evaluate the association of notification with this surgeon-level outcome. The surgeon-level metric of mean stages per case was not risk adjusted. The mean Medicare cost savings associated with changes in practice patterns were calculated.Of the 2329 included surgeons, 1643 (70.5%) were male and 2120 (91.0%) practiced in metropolitan areas. In the intervention group (n = 1045), 53 surgeons (5.1%) were outliers; in the control group (n = 1284), 87 surgeons (6.8%) were outliers. Among the outliers in the intervention group, 44 (83%) demonstrated a reduction in mean stages per case compared with 60 outliers in the control group (69%; difference, 14%; 95% CI of difference, -1 to 27; P = .07). There was a mean stages-per-case reduction of 12.6% among outliers in the intervention group compared with 9.0% among outliers in the control group, and outliers in the intervention group had an adjusted postintervention differential decrease of 0.14 stages per case (95% CI, -0.19 to -0.09; P = .002). The total administrative cost of the intervention program was $150 000, and the estimated reduction in Medicare spending was $11.1 million.Sharing personalized practice pattern data with physicians benchmarked to their peers can reduce overuse of MMS among outlier physicians.
Picture quiz: Head injury and decreased consciousness
Authors: Senthil K Selvanathan, Tony Goldschlager, Jeffrey V Rosenfeld, Rebecca D Udani, Sundip D Udani, Lisa M Jackson
Journal: BMJ (2007)

A 32 year old woman was hit by a car. When the ambulance arrived she was awake and talking, but she seemed confused and said she had a headache. At the emergency department she was still confused and said she had a severe headache. No focal neurological deficits were detected. Radiography of the skull showed a left parietal fracture. Shortly after admission to the ward she vomited and her level of consciousness was recorded using the Glasgow coma scale and was found to be deteriorating. A right extensor plantar response was found on examination. An emergency computed tomogram was taken (fig 1). Fig 1 Emergency axial computed tomogram
E-learning: Is it the end of medical schools?
Authors: Jason O'Neale Roach
Journal: BMJ (2001)

The internet will radically change medical education The next decade may see the emergence of a new type of medical school. It will not be made of bricks and mortar, but based mostly in the hard drives of computers, accessible by thousands of students all over the world. New investment trends are driving this efficient, cheap, and convenient way of delivering information. While patient contact will remain integral to learning medicine, perhaps what will emerge is a way to personalise education, reduce costs for students, and prepare them more thoroughly for contact with patients.

In November 2000 Sir Brian Fender, head of the Higher Education Funding Council for England, called on private sector investors to take a stake in his £200m venture to set up an …
A guide to medical etiquette: deadlines
Authors: David McAllister
Journal: BMJ (2001)

End of term should be a joyous occasion, yet for some reason it is not. Instead people seem belligerent. They are snappish with their families and flatmates, and don't stop to chat with their colleagues. Even as Christmas approaches we see this kind of conduct.

The reason is, of course, that they have essay and report deadlines.

To the casual observer, it is always obvious when a deadline is …
A wake-up call for European medical education
Authors: Sara Carrillo de Albornoz, Tiago Villanueva
Journal: BMJ (2007)

<b>Mariapia Magni</b> is leading a European project that looks at the new challenges facing medical education-Medical Assistance and The rapy in Europe (MATE). She spoke to Sara Carrillo de Albornoz and Tiago Villanueva about the need for a change, and she hopes that governments, universities, and hospitals work together to improve medicine in Europe
When babies die
Authors: Joanna Tymms
Journal: BMJ (2008)

With pain can come strength

Sometimes people experience things that change them in some way, and it can happen within the space of half an hour. It happened to me when I saw a baby die: it was the saddest thing I've ever seen. I left the resuscitation room that night because it was too difficult to stay as his mother cried with such desperation.



I was warned at the start of my placement in emergency medicine that I might see things that would affect me, but I was not prepared for this. I felt as though a part of me was lost, but with time I've realised that it's been replaced with something that will be beneficial. Having been in a numb state, where I couldn't listen to what a comforting doctor said, has made me realise that compassion can be felt even if the words aren't heard. Perhaps the main component of breaking bad news is the empathy; previously I'd worried about the exact words I'd use.

Doctors can't always win, no matter how unjust losing seems. It's best to experience glimpses of this as a medical student, when there's time to reflect. One day I may be the doctor who needs to put their own emotions to one side to talk to people who will be affected by tragedy for the rest of their lives. The doctor needs to do this and then …
ww.whonamedit.com
Authors: Shivani Misra
Journal: BMJ (2003)

Following on from this month's education article Beyond the name (p276), have you ever wondered who Robert Graves was? Or maybe James Paget caught your interest? Even if you're not that curious, here's a chance to find out all about them, and more. www.whonamedit.com is a biographical dictionary of over 6000 medical eponyms (people after whom something is named). Compiled by a Norwegian group, the site aims to ultimately provide a comprehensive collection of 15 000 eponyms, …
The role of role models
Authors: Irina Haivas
Journal: BMJ (2007)

I come from a developing country where to leave or to stay is an omnipresent topic-from official debates to conversations in the corridors. As we approach graduation, this talk becomes more heated. Often the students who most seriously contemplate leaving the country and who also have the best chance are among the best and most ambitious graduates.

I often asked myself how a developing country can compete for these young professionals. Everyone talks about better payment and training-and I could not argue about the importance of these. But a less obvious part of the solution …
Is It Time for Safeguards in the Adoption of Robotic Surgery?
Authors: Kyle H. Sheetz, Justin B. Dimick
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
One in five students with piercings have complications
Authors: Jamie Wilson
Journal: BMJ (2002)

The largest ever “body art” study has found that a fifth of students with body piercings have excessive bleeding, bacterial infection, and tissue trauma. The research was reported in Mayo Clinic Proceedings (2002;77:29-34) after 454 undergraduates from a New York college completed questionnaires on the subject.

More than half (51%) of the students had piercings outside the traditional domain …
Problem based learning better prepares students for practice
Authors: Karen Hebert
Journal: BMJ (2005)

Medical graduates who have followed a problem based learning (PBL) course report that they have a different set of skills when they start working than students who have followed a traditional course (Medical Education 2005;39: 394-401).

Katinka Prince and colleagues analysed responses from 1159 graduates from one PBL (239) and four non-PBL (917) medical schools in the Netherlands. (At the time of the study there was only one PBL medical school in the Netherlands.) Graduates answered a questionnaire 18 months after graduating.

“We explored graduates' perceptions of how well their training had prepared them for medical practice, particularly in general competencies. We compared the opinions of graduates from PBL and non-PBL schools, because PBL is supposed to enhance general competencies,” Dr Prince explained.

The PBL graduates rated their quality of training, and in turn, their preparation for practice, significantly more highly than their non-PBL counterparts. Non-PBL graduates (83%) ranked their own expert medical knowledge significantly more highly than the PBL graduates (72%). Most PBL graduates (83%) considered that they had competent communication skills in contrast to a minority of non-PBL graduates (41%).

Dr Prince said, “This study showed that PBL graduates gave higher ratings for the connection between school and work and their preparation for practice. We expected this as PBL is supposed to enhance preparation for practice. We found it interesting that the PBL school appeared to provide better preparation with respect to several of the competencies needed in practice—profession specific skills, communication skills, and teamwork.”

The study showed, however, that most graduates (46% PBL and 34% non-PBL) report a lack of training in computer work, planning and organisation skills, and leadership skills at medical school. Most graduates (53% PBL and 58% non-PBL) agreed that although they had attained most of their knowledge during medical school, they had learnt …
The nonsteroidal FXR agonist cilofexor (GS-9674) improves markers of cholestasis and liver injury in patients with PSC.
Authors: Michael Trauner, Aliya Gulamhusein, Bilal Hameed, Stephen Caldwell, Mitchell L Shiffman, Charles Landis, Bertus Eksteen, Kosh Agarwal, Andrew Muir, Simon Rushbrook, Xiaomin Lu, Jun Xu, Jen-Chieh Chuang, Andrew N Billin, Chuhan Chung, Georgia Li, G Mani Subramanian, Robert P Myers, Christopher L Bowlus, Kris Kowdley
Journal: Hepatology (2019)
Police end strike at university in Mexico City
Authors: Sian Knight
Journal: BMJ (2000)

The nine month sit-in at the National Autonomous University of Mexico has ended as more than 2200 police tore down barricades, took possession of the main campus in Mexico City, and arrested 632 students. The university is Latin America's largest educational institution, with a population of 270 000, and the site of Mexico's leading medical and law schools. The students' prolonged strike started in response to plans to increase fees from a nominal payment of around two US cents to US$70 (£43). This month's police action came a week after hundreds of students, angry at the disruption of …
Androgen Receptor Burden and Poor Response to Abiraterone or Enzalutamide in <i>TP53</i> Wild-Type Metastatic Castration-Resistant Prostate Cancer
Authors: Bram De Laere, Prabhakar Rajan, Henrik Grönberg, Luc Dirix, Johan Lindberg
Journal: JAMA Oncology (2019)

This post hoc analysis of a multi-institution cohort study assesses the association between androgen receptor perturbation and poorer outcome in patients with TP53 wild-type metastatic castration-resistant prostate cancer who are receiving abiraterone or enzalutamide.
Kitemarks won't cure ‘Cyberchondriacs’
Authors: Nadeeja Koralage
Journal: BMJ (2004)

My first experience of “internet print out syndrome” was in a suburban general practitioner's surgery. The syndrome seemed to affect essentially healthy people who wanted to go to the doctor to have a lengthy discussion about minor symptoms. Perhaps they had undergone early retirement and were now so bored that they were desperate to have an excuse to chat with a doctor. And if they got a prescription out of it, that was a bonus-they got a chat with a pharmacist too. These “cyberchondriacs” tended to be financially comfortable enough to believe that good health was …
My father is the wise man of the village
Authors: Andrew Moscrop
Journal: BMJ (2002)

“My father is the wise man of the village”—large, in buzzing red neon striplight, currently confronts visitors to Edinburghs Fruitmarket Gallery. Artist Kate Gray took the statement from the thought filled sketchbooks of psychiatric patient Nicky Barrett. The resulting work, in neon, unashamedly presents Nickys private world of thoughts to the public and lends its title to the products of FUSION.



The two year FUSION programme enabled established artists to work within hospitals in the Edinburgh and Lothians region. It comprised two projects: Commissions, in which eight artists produced works specific to several specialised hospital departments in the region; and Collaborations, in …
State-Specific Severe Joint Pain and Physical Inactivity Among Adults with Arthritis — United States, 2017
Authors: Dana Guglielmo, Louise B. Murphy, Michael A. Boring, Kristina A. Theis, Charles G. Helmick, Jennifer M. Hootman, Erica L. Odom, Susan A. Carlson, Yong Liu, Hua Lu, Janet B. Croft
Journal: MMWR Morbidity and Mortality Weekly Report (2019)

An estimated 54.4 million (approximately one in four) U.S. adults have doctor-diagnosed arthritis (arthritis) (1). Severe joint pain and physical inactivity are common among adults with arthritis and are linked to adverse mental and physical health effects and limitations (2,3). CDC analyzed 2017 Behavioral Risk Factor Surveillance System (BRFSS) data to estimate current state-specific prevalence of arthritis and, among adults with arthritis, the prevalences of severe joint pain and physical inactivity. In 2017, the median age-standardized state prevalence of arthritis among adults aged ≥18 years was 22.8% (range = 15.7% [District of Columbia] to 34.6% [West Virginia]) and was generally highest in Appalachia and Lower Mississippi Valley regions.* Among adults with arthritis, age-standardized, state-specific prevalences of both severe joint pain (median = 30.3%; range = 20.8% [Colorado] to 45.2% [Mississippi]) and physical inactivity (median = 33.7%; range = 23.2% [Colorado] to 44.4% [Kentucky]) were highest in southeastern states. Physical inactivity prevalence among those with severe joint pain (47.0%) was higher than that among those with moderate (31.8%) or no/mild joint pain (22.6%). Self-management strategies such as maintaining a healthy weight or being physically active can reduce arthritis pain and prevent or delay arthritis-related disability. Evidence-based physical activity and self-management education programs are available that can improve quality of life among adults with arthritis.
A guide to medical etiquette: radiology
Authors: David McAllister
Journal: BMJ (2001)

At your interview for medical school (if you were interviewed) when you said why you wanted to be a doctor (if you were asked) it may be that you said, “I want to work in dark rooms away from patients starting at bright shiny boxes.” However, I guess that few of you said any such thing. None the less, people change, aspirations grow, and no doubt some of you will become radiologists.

Radiology is a modern specialty. Modern in …
Heterogeneity in Major Depressive Disorder: Lessons From Developmental Research on Irritability
Authors: Daniel S. Pine
Journal: American Journal of Psychiatry (2019)

Clinical heterogeneity thwarts efforts to understand the pathophysiology, course, and treatment of most, if not all, mental disorders.However, such effects create unique difficulties for research on major depressive disorder due to the high levels of clinical heterogeneity found in this condition.In this issue of the Journal, Jha and colleagues (1) address this problem by examining levels of irritability as a clinical moderator of treatment outcome.Among adults with major depressive disorder, the authors assessed irritability as a predictor of response to pharmacological treatment delivered within the context of a clinical trial.Jha and colleagues showed that changes in irritability occurring during the early phase of treatment predicted the later response of depressive symptoms to antidepressant medications.These findings suggest that elevated symptoms of irritability and their early change with treatment may help to identify a unique clinical subgroup of depressed adults, manifesting a distinct therapeutic profile.Although such findings are clearly novel, other aspects of Jha and colleagues' work are notable.For example, the authors grounded their analyses in "real-world" samples assessed with methods designed to directly inform clinical practice.They employed assessment techniques that require relatively little training to be used effectively by clinicians, and they used these techniques as part of a measurement-based care approach, which also can be readily taken up by clinicians actively delivering care.Moreover, the data were acquired in two large, independent cohorts.The methods in each cohort were similar enough to allow meaningful comparisons but different enough to provide insights on generalizability.The comparability of findings in the two cohorts further speaks to their importance.
The Tuberculosis Survival Handbook
Authors: Amy McLaughlin
Journal: BMJ (1999)

We have all heard the statistics about tuberculosis, as one of the world's biggest killers, its re-emergence in the light of HIV and AIDS, and the problems of multidrug resistance. However, We are, however, inclined to doubt the relevance of this disease to us in clinical practice in the United Kingdom, and few of us would realise what a patient diagnosed with tuberculosis …
The face of 32000 students
Authors: Nadeeja Koralage
Journal: BMJ (2006)

Kirsty Lloyd trained professionally as a dancer for 10 years, starting at the age of 11. Now aged 32, she9s an intercalating medical student at Leicester University and head of the BMA9s Medical Students Committee, representing the United Kingdom9s 32 000 medical students. <b>Nadeeja Koralage</b> finds out how she got there
Learning from patients
Authors: Fiona Price-Kuehne
Journal: BMJ (2008)

Emery's Elements of Medical Genetics, includes sections on the principles of human genetics.



“Damn it!” said the medical student as he marched down the corridor without so much as a smile. It seemed that my status as an ill, 15 year old patient had just been reduced to a missed opportunity. He needed my notes for his case study. Instead of helping with my emergency transfer to a specialist hospital, the student was more bothered about meeting his deadline.

Aged only 15, I was not your typical patient with Wegener's granulomatosis. At first the doctors puzzled over …