Vaccine Safety in Pregnancy: Going Beyond the Perinatal Period
Authors: Anders Hviid
Journal: Annals of Internal Medicine (2020)

Editorials20 October 2020Vaccine Safety in Pregnancy: Going Beyond the Perinatal PeriodAnders Hviid, MSc, DrMedSciAnders Hviid, MSc, DrMedSciStatens Serum Institut and University of Copenhagen, Copenhagen, Denmark (A.H.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M20-5489 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail There is no doubt that vaccination in pregnancy is an important strategy for influenza prevention (1). Influenza infection in pregnancy can pose serious health risks to mother and child. Vaccination in pregnancy not only protects the mother and fetus but also provides protection in infancy directly by transfer of maternal antibodies and indirectly by preventing transmission from the mother. However, despite these benefits, pregnant women have not universally embraced influenza vaccination. Maternal influenza vaccination has gained some traction in relation to the 2009 influenza pandemic and is now widely recommended, but uptake remains at best moderate in most countries (2). ...References1. ACOG committee opinion no. 732: influenza vaccination during pregnancy. . Obstet Gynecol. 2018;131:e109-e114. [PMID: 29578985] doi:10.1097/AOG.0000000000002588 CrossrefMedlineGoogle Scholar2. Jorgensen P, Mereckiene J, Cotter S, et al. How close are countries of the WHO European Region to achieving the goal of vaccinating 75% of key risk groups against influenza? Results from national surveys on seasonal influenza vaccination programmes, 2008/2009 to 2014/2015. Vaccine. 2018;36:442-452. [PMID: 29287683] doi:10.1016/j.vaccine.2017.12.019 CrossrefMedlineGoogle Scholar3. Giles ML, Krishnaswamy S, Macartney K, et al. The safety of inactivated influenza vaccines in pregnancy for birth outcomes: a systematic review. Hum Vaccin Immunother. 2019;15:687-699. [PMID: 30380986] doi:10.1080/21645515.2018.1540807 CrossrefMedlineGoogle Scholar4. Ludvigsson JF, Winell H, Sandin S, et al. Maternal influenza A(H1N1) immunization during pregnancy and risk for autism spectrum disorder in offspring. A cohort study. Ann Intern Med. 2020;173:597-604. doi:10.7326/M20-0167 LinkGoogle Scholar5. Bai D, Yip BHK, Windham GC, et al. Association of genetic and environmental factors with autism in a 5-country cohort. JAMA Psychiatry. 2019. [PMID: 31314057] doi:10.1001/jamapsychiatry.2019.1411 CrossrefMedlineGoogle Scholar6. Walsh LK, Donelle J, Dodds L, et al. Health outcomes of young children born to mothers who received 2009 pandemic H1N1 influenza vaccination during pregnancy: retrospective cohort study. BMJ. 2019;366:l4151. [PMID: 31292120] doi:10.1136/bmj.l4151 CrossrefMedlineGoogle Scholar7. Hviid A, Svanström H, Mølgaard-Nielsen D, et al. Association between pandemic influenza A(H1N1) vaccination in pregnancy and early childhood morbidity in offspring. JAMA Pediatr. 2017;171:239-248. [PMID: 27893898] doi:10.1001/jamapediatrics.2016.4023 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Statens Serum Institut and University of Copenhagen, Copenhagen, Denmark (A.H.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M20-5489.Corresponding Author: Anders Hviid, MSc, DrMedSci, Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark; e-mail, [email protected]dk.This article was published at Annals.org on 1 September 2020. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMaternal Influenza A(H1N1) Immunization During Pregnancy and Risk for Autism Spectrum Disorder in Offspring Jonas F. Ludvigsson , Henric Winell , Sven Sandin , Sven Cnattingius , Olof Stephansson , and Björn Pasternak Metrics Cited byIn utero exposure to influenza vaccine not associated with ASD in children 20 October 2020Volume 173, Issue 8Page: 658-659KeywordsAutismChild healthInfectious diseasesInformation storage and retrievalPerceptionPregnancyPrevention, policy, and public healthSafetySafety studiesVaccines ePublished: 1 September 2020 Issue Published: 20 October 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...