tbuckley/cabot-search huggingface dataset:
TCT-232 Incidence and Prognosis of Chronic Total Occlusions in Noninfarct-Related Artery in Patients With ST-Segment Elevation Myocardial Infarction
Authors: Anthony Main, Ameen Basha, Alain Malebranche, Kevin Bainey, Merril Knudtson, Mouhieddin Traboulsi, Benjamin Tyrrell, Bryan Har
Journal: Journal of the American College of Cardiology (2019)
TCT-354 Evaluation of a New Food and Drug Administration–Approved Optical Coherence Tomography Method for Stent Expansion in an All-Comers Population
Authors: Luis Dallan, Gabriel Tensol Rodrigues Pereira, Elder Zago, Armando Vergara-Martel, Patricia Ely Pizzato, Vladislav Zimin, Anas Fares, Marco Costa, Guilherme Attizzani, Hiram Bezerra
Journal: Journal of the American College of Cardiology (2019)
Measurement of Hyperemic Pullback Pressure Gradients to Characterize Patterns of Coronary Atherosclerosis
Authors: Carlos Collet, Jeroen Sonck, Bert Vandeloo, Takuya Mizukami, Bram Roosens, Stijn Lochy, Jean-Francois Argacha, Danny Schoors, Iginio Colaiori, Giuseppe Di Gioia, Monika Kodeboina, Hiroshi Suzuki, Marcel Van ’t Veer, Jozef Bartunek, Emanuele Barbato, Bernard Cosyns, Bernard De Bruyne
Journal: Journal of the American College of Cardiology (2019)
TCT-726 Infolding of Self-Expanding Transcatheter Aortic Valve: Diagnosis, Management and Outcomes
Authors: Anees Musallam, Toby Rogers, Itsik Ben-Dor, Rebecca Torguson, Cheng Zhang, Nauman Khalid, Yuefeng Chen, Evan Shlofmitz, Jaffar Khan, Micaela Iantorno, Deepakraj Gajanana, James Edelman, Lowell Satler, Ron Waksman
Journal: Journal of the American College of Cardiology (2019)
Diabetes Is Associated With Worse Long-term Outcomes in Young Adults After Myocardial Infarction: The Partners YOUNG-MI Registry
Authors: Sanjay Divakaran, Avinainder Singh, David Biery, Junjie Yang, Ersilia M. DeFilippis, Bradley L. Collins, Mattheus Ramsis, Arman Qamar, Jon Hainer, Josh Klein, Christopher P. Cannon, Donna M. Polk, Jorge Plutzky, Khurram Nasir, James L. Januzzi, Marcelo F. Di Carli, Deepak L. Bhatt, Ron Blankstein
Journal: Diabetes Care (2019)

We sought to determine the prevalence of diabetes and associated cardiovascular outcomes in a contemporary cohort of young individuals presenting with their first myocardial infarction (MI) at age ≤50 years.
TCT-633 Impact of Diabetes on the Outcomes of Chronic Total Occlusion Percutaneous Coronary Interventions: An Updated Systematic Review and Meta-Analysis
Authors: Abdelrahman Ali, Osama Hallak, Marwan Saad, Mohamed Omer, Ayman Elbadawi, Karim Al-Azizi, Islam Elgendy, Michael Megaly
Journal: Journal of the American College of Cardiology (2019)
TCT-585 Prognostic Implications of Coronary Physiologic Indices in Deferred Coronary Artery Lesions With Diabetes Mellitus
Authors: Doyeon Hwang, Jinlong Zhang, Joo Myung Lee, Jae-Jin Kwak, Joon-Hyung Doh, Chang-Wook Nam, Eun-Seok Shin, Tsunekazu Kakuta, Javier Escaned, Bon-Kwon Koo
Journal: Journal of the American College of Cardiology (2019)
Measuring the Quality of Diabetes Care—Reply
Authors: Rozalina G. McCoy, Rene Rodriguez-Gutierrez
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Safety and activity of sunitinib in elderly patients (75 years or more) with metastatic renal cell carcinoma: Results of retrospective study in Paoli-Calmettes Cancer Institute in France.
Authors: Lamia Boulaamane, Frederique Rousseau, Maud Cecile, Cecile Braticevic, Slimane Dermeche, Jochen Walz, Naji Salem, Serge Brunelle, Jeanne Thomassin, Hassan Errihani, Gwenaelle Gravis
Journal: Journal of Clinical Oncology (2013)

e15506 Background: Actual tolerability of cancer treatment is still poorly documented in elderly patients. Recently some retrospective reviews have been carried out to evaluate tolerability and efficacy of Sunitinib in elderly patients (&gt; 65 years), with metastatic renal cell carcinoma (mRCC) enrolled in clinical trials. Yet data on routine clinical practice are still lacking. Methods: Between January 2009 and May 2012, 17 patients &gt;= 75 years treated with Sunitinib for mRCC were reviewed, to assess toxicity, cause of treatment reduction or discontinuation. Correlation of toxicity with 7 domains comprehensive geriatric assessment (CGA), tumoral response and progression-free survival (PFS) were also analysed. Results: The median age was 79 years, and patients were followed-up until September 2012. The majority of patients were in the MSKCC favourable or intermediate-risk groups. Eleven patients have received Sunitinib in first line. The median dose received was 37.5mg. Grade II-III diarrhea was observed in 6 patients and grade I-II hand-foot syndrome in 9 patients. Treatment was stopped earlier (&lt; 50 days) for 4 pts, due to severe toxicity: hospitalization in intensive care unit, oesophageal ulceration, asthenia and malnutrition. Temporary treatment discontinuation was observed for 3 pts. All patients underwent 7 domains CGA, and were classified according to Balducci scale. Correlation was not found between impairment at CGA with severe toxicity nor with response, but correlation was found between initial dose and treatment discontinuation. Sunitinib at level of 50 mg was associated with early and permanent treatment discontinuation, and initial dose reduction was associated with an acceptable safety profile and long time treatment duration. Response rate was 41.1% for partial response and 41.1% for stable disease. Median PFS was 23.3 months. Conclusions: This is the first retrospective study performed in elderly cancer patients aged over 75 years. There is no evident correlation between CGA impairment and toxicity profile of Sunitinib. Low starting and dose escalation in the absence of severe toxicity could be suggested.
Systematic assessment of complications after robotic-assisted total versus distal gastrectomy for advanced gastric cancer: A retrospective propensity score-matched study using Clavien–Dindo classification
Authors: Wen-Jie Wang, Rui Li, Chang-An Guo, Hong-Tao Li, Jian-Ping Yu, Jing Wang, Zi-Peng Xu, Wei-Kai Chen, Zhi-Jian Ren, Peng-Xian Tao, Ya-Nan Zhang, Chen Wang, Hong-Bin Liu
Journal: International Journal of Surgery (2019)
TCT-510 SYNTAX Score II Application for Prediction of Heart Failure Development in Patients With STEMI Undergoing Primary Percutaneous Coronary Intervention
Authors: Fernando Gómez Peña, Ana Belen Cid Alvarez, Alfredo Redondo Dieguez, Javier Lopez-Pais, Diego Lopez Otero, Ramiro Trillo Nouche
Journal: Journal of the American College of Cardiology (2019)
TCT-607 Optimizing Safety and Efficacy of Lesion Formation for Percutaneous Renal Denervation: Human and Porcine Histological Analysis
Authors: Andrew Sharp, Stefan Tunev, Markus Schlaich, David Lee, Aloke Finn, Robert Melder, Paul Coates, Julie Trudel, David Kandzari
Journal: Journal of the American College of Cardiology (2019)
Differential Glycosylation Between Recombinant Factor VIII Produced in Baby Hamster Kidney and Chinese Hamster Ovary Cells Confers Differences in Immunogenicity in a Humanized Hemophilia Α Mouse Model
Authors: Jesse Lai, Laura L Swystun, Dominique Cartier, Cunjie Zhang, Kate Nesbitt, James Dennis, Christine Hough, David Lillicrap
Journal: Blood (2016)
Campaign group urges GMC to support doctors taking direct action against climate change
Authors: Gareth Iacobucci
Journal: BMJ (2019)

The cofounder of the campaign group Doctors for Extinction Rebellion1 has called on the General Medical Council to support doctors taking direct action against climate change, following a protest in Westminster last week.

Chris Newman, a GP in north London and cofounder of Doctors for XR, was one of several doctors who scaled and then glued themselves to the building of the Department for Business, Energy, and Industrial Strategy on 25 September.

The group, which formed earlier this year,2 said they had carried out the act of “peaceful civil disobedience” to deliver an “urgent health warning” about the severity of …
Polygenic Risk Scores for Breast Cancer Risk Prediction: Lessons Learned and Future Opportunities
Authors: Julie R Palmer
Journal: JNCI Journal of the National Cancer Institute (2019)

In this issue of the Journal, Shieh et al. report findings from an assessment of performance of a polygenic risk score (PRS) for breast cancer in Latin American women (Latinas) (1).Study participants were either residents of the Western United States whose genetic ancestry was primarily a mix of Indigenous American and European ancestry or residents of Latin American countries (ie, Mexico, Colombia, and Peru).The PRS was developed based on single nucleotide polymorphisms (SNPs) identified from genome-wide association studies (GWASs) conducted in largely European-ancestry populations.The results indicate that a PRS of approximately 180 SNPs had relatively high discriminatory accuracy, with an area under the curve (AUC) of 0.63 (95% confidence interval [CI] ¼ 0.62-0.64).Importantly, this AUC is identical to the AUC derived in the largest such analysis of European-ancestry women (2).That study included more than 100 000 breast cancer cases and 100 000 controls.For a PRS based on 3082 SNPs, the AUC was 0.630 (95% CI ¼ 0.628-0.651).The consistency of the present report with results from the largest study of European-ancestry women suggests that PRS developed based on GWAS findings from European-ancestry women may be equally useful for Latinas.It will not be necessary to wait years until GWASs of tens of thousands of Latinas with breast cancer have been conducted.Instead, the PRS tested by Shieh et al. can be used for Latinas from the Western United States and Latin America just as existing PRS are used for U.S. women of European ancestry.The findings fill a critical knowledge gap and may have immediate public health impact.Latinas constitute a large and rapidly growing population group, yet commercial laboratories currently do not return PRS results to these women.Given that information from a PRS has the potential to improve stratification for breast cancer screening, it is imperative that Latinas have access to the same PRS feedback as women of European ancestry do.It may not be surprising that a PRS based on SNPs identified in European-ancestry women performs equally well in Latinas,
Effectiveness of complete decongestive therapy (CDT) in managing secondary lymphedema after modified radical mastectomy (MRM).
Authors: Kunal Jain, Mullai Dhinakaran, Kamlakshi Esther Benjamin
Journal: Journal of Clinical Oncology (2012)

e19622 Background: Lymphedema of ipsilateral arm is one of the common complications seen after MRM with varying incidence reported in literature ranging from 5% to 56%. Several therapeutic interventions exist to treat this potentially distressing and disabling condition, but no consensus regarding definitive treatment of lymphedema has been reached. Methods: We conducted a single centre, prospective pilot study in patients with secondary lymphedema developed after treatment of breast cancer. These subjects were selected according to predefined criteria with duly signed consent form, from Outpatient Department of Physiotherapy, Christian Medical College and Hospital, Ludhiana. Lymphedema assessment with limb volume measurement was done using modified truncated cone method. A daily intervention program of CDT was implemented consisting of education about skin care, manual lymph drainage techniques, compression garments and exercise for 45 minutes per day for 10 days. The patients were assessed at baseline and on 10 th day. During this10 day supervised therapy in the hospital, patients were also trained to continue this therapy at home. Results: Fifteen patients have been enrolled prospectively in this study between March 2011 and December 2011. The mean age at presentation was 43.5 yrs (range 35-58 yrs). All patients underwent MRM and the mean duration of presentation from the time of MRM to development of lymphedema was 12.5 months (3-24 months). The mean pre-treatment volumes of normal and affected arms were 332.47mL (240-425mL) and 416.62mL (277.6-535.5 mL) respectively (p=0.004). Mean post treatment volume of affected limb at the end of 10 th day was 329.93mL (249-400mL) showing an absolute reduction in mean volume of affected arm by 86.69 mL (p=0.02). Conclusions: Complete decongestive therapy was helpful in significant reduction of secondary lymphedema after MRM in this small patient group. These findings need to be verified in a larger sample size comparing other modalities used in managing lymphedema. CDT needs to be tested in early post-operative setting to assess its role in decreasing incidence of lymphedema after MRM.
NPM1 Mutated AML Can Relapse with Wildtype NPM1 and Evolve with Novel Mutations: Implications for Pathobiology and MRD Monitoring
Authors: Alexander Höllein, Manja Meggendorfer, Annette Fasan, Frank Dicker, Sabine Jeromin, Niroshan Nadarajah, Wolfgang Kern, Claudia Haferlach, Torsten Haferlach
Journal: Blood (2017)
Single-cell transcriptomics reveal polyclonal memory T-cell responses in skin with positive abacavir patch test results
Authors: Alec James Redwood, Francois Rwandamuriye, Abha Chopra, Shay Leary, Ramesh Ram, Wyatt McDonnell, Katherine Konvinse, Katie White, Rebecca Pavlos, David M. Koelle, Simon Mallal, Elizabeth J. Phillips
Journal: Journal of Allergy and Clinical Immunology (2019)
MiR‐31‐5p: A shared regulator of chronic mucus hypersecretion in asthma and chronic obstructive pulmonary disease
Authors: Hataitip Tasena, Ilse M. Boudewijn, Alen Faiz, Wim Timens, Machteld N. Hylkema, Marijn Berg, Nick H. T. ten Hacken, Corry‐Anke Brandsma, Irene H. Heijink, Maarten van den Berge
Journal: Allergy (2019)

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
TCT-590 The Current Status of Intervention for Intermediate Coronary Stenosis in the Korean Percutaneous Coronary Intervention (K-PCI) Registry
Authors: Jin-Ho Kim, Chang-Wook Nam, Bum-Kee Hong, June-Hong Kim, Doo Soo Jeon, Jang Whan Bae, Sang-Hyun Kim, Keon-Woong Moon, Byung-Ryul Cho, None doo Il Kim, Jae-Sik Jang
Journal: Journal of the American College of Cardiology (2019)
Association of Relative Age in the School Year With Diagnosis of Intellectual Disability, Attention-Deficit/Hyperactivity Disorder, and Depression
Authors: Adrian Root, Jeremy P. Brown, Harriet J. Forbes, Krishnan Bhaskaran, Joseph Hayes, Liam Smeeth, Ian J. Douglas
Journal: JAMA Pediatrics (2019)

Young relative age within the school year has previously been associated with attention-deficit/hyperactivity disorder (ADHD) diagnosis and, based on limited evidence, diagnosis of intellectual disability. No study to date has examined the association between relative age and diagnosis of depression.
Early Thrombotic Events Following Splenectomy for Myelofibrosis: Incidence, Risk Factors and Effect of Pre-Emptive Anticoagulant Therapy
Authors: Mythri Mudireddy, Naseema Gangat, Terra L. Lasho, Christy Finke, Curtis A. Hanson, Rhett P. Ketterling, Aneel A. Ashrani, Animesh Pardanani, David M. Nagorney, Ayalew Tefferi
Journal: Blood (2017)
Low-Dose ATG Combined with Facybu Conditioning Regimen Followed By Single Unrelated Cord Blood Transplantation in Hematological Malignancies
Authors: Yating Jiang, Xiaofan Li, Jiafu Huang, Zheng Jing, Haiying Fu, Jianda Hu, Yuanzhong Chen, Nainong Li
Journal: Blood (2017)
TCT-765 Anatomic Correlates of Residual Left-to-Right Shunt After Suture-Based Percutaneous Closure of Patent Foramen Ovale
Authors: Achille Gaspardone, Gaetano Gioffrè, Fabiana Piccioni, Maria Iamele, Emanuela D’Ascoli, Antonella De Santis, Fabrizio D’Errico, Francesco Summaria, Alessio Stanzione, Maria Benedetta Giannico, Mauro Polzoni, Gregory Sgueglia
Journal: Journal of the American College of Cardiology (2019)
Changes in Serum B-Cell Maturation Antigen Levels Rapidly Indicate Changes in Clinical Status Among Multiple Myeloma Patients Undergoing New Treatments
Authors: Sean Bujarski, Kyle Udd, Camilia Soof, Haiming Chen, Mingjie Li, Eric Sanchez, Joshua Stern, Cathy S Wang, Marsiye Emamy-Sadr, Regina Swift, Ashkon Rahbari, Saurabh Patil, James R Berenson
Journal: Blood (2017)
Mismatched related vs matched unrelated donors in TCRαβ/CD19-depleted HSCT for primary immunodeficiencies
Authors: Alexandra Laberko, Elvira Sultanova, Elena Gutovskaya, Irina Shipitsina, Larisa Shelikhova, Elena Kurnikova, Yakov Muzalevskii, Alexei Kazachenok, Dmitriy Pershin, Kirill Voronin, Anna Shcherbina, Michael Maschan, Alexey Maschan, Dmitry Balashov
Journal: Blood (2019)
TCT-93 Results From the Early Feasibility Study of Cardioband Tricuspid System for Functional Tricuspid Regurgitation
Authors: William Gray, Scott Lim, Susheel Kodali, Rebecca Hahn, Robert Smith, Paul Grayburn, Mackram Eleid, Robert Kipperman, Sandra Abramson, Dale Fowler, Sorin Pislaru, Konstantinos Koulogiannis, Jyothy Puthumana, Charles Davidson
Journal: Journal of the American College of Cardiology (2019)
Immediate impact of minimum unit pricing on alcohol purchases in Scotland: controlled interrupted time series analysis for 2015-18
Authors: Amy O’Donnell, Peter Anderson, Eva Jané-Llopis, Jakob Manthey, Eileen Kaner, Jürgen Rehm
Journal: BMJ (2019)

To assess the immediate impact of the introduction of minimum unit pricing in Scotland on household alcohol purchases.Controlled interrupted time series analysis.Purchase data from Kantar Worldpanel's household shopping panel for 2015-18.5325 Scottish households, 54 807 English households as controls, and 10 040 households in northern England to control for potential cross border effects.Introduction of a minimum price of 50p (€0.55; $0.61) per UK unit (6.25p per gram) for the sale of alcohol in Scotland on 1 May 2018.Price per gram of alcohol, number of grams of alcohol purchased from off-trade by households, and weekly household expenditure on alcohol.The introduction of minimum unit pricing in Scotland was associated with an increase in purchase price of 0.64p per gram of alcohol (95% confidence interval 0.54 to 0.75), a reduction in weekly purchases of 9.5 g of alcohol per adult per household (5.1 to 13.9), and a non-significant increase in weekly expenditure on alcohol per household of 61p (-5 to 127). The increase in purchase price was higher in lower income households and in households that purchased the largest amount of alcohol. The reduction in purchased grams of alcohol was greater in lower income households and only occurred in the top fifth of households by income that purchased the greatest amount of alcohol, where the reduction was 15 g of alcohol per week (6 to 24). Changes in weekly expenditure were not systematically related to household income but increased with increasing household purchases.In terms of immediate impact, the introduction of minimum unit pricing appears to have been successful in reducing the amount of alcohol purchased by households in Scotland. The action was targeted, in that reductions of purchased alcohol only occurred in the households that bought the most alcohol.
Genome-Wide Analysis of Left Ventricular Image-Derived Phenotypes Identifies Fourteen Loci Associated With Cardiac Morphogenesis and Heart Failure Development
Authors: Nay Aung, Jose D. Vargas, Chaojie Yang, Claudia P. Cabrera, Helen R. Warren, Kenneth Fung, Evan Tzanis, Michael R. Barnes, Jerome I. Rotter, Kent D. Taylor, Ani W. Manichaikul, Joao A.C. Lima, David A. Bluemke, Stefan K. Piechnik, Stefan Neubauer, Patricia B. Munroe, Steffen E. Petersen
Journal: Circulation (2019)

The genetic basis of left ventricular (LV) image-derived phenotypes, which play a vital role in the diagnosis, management, and risk stratification of cardiovascular diseases, is unclear at present.The LV parameters were measured from the cardiovascular magnetic resonance studies of the UK Biobank. Genotyping was done using Affymetrix arrays, augmented by imputation. We performed genome-wide association studies of 6 LV traits-LV end-diastolic volume, LV end-systolic volume, LV stroke volume, LV ejection fraction, LV mass, and LV mass to end-diastolic volume ratio. The replication analysis was performed in the MESA study (Multi-Ethnic Study of Atherosclerosis). We identified the candidate genes at genome-wide significant loci based on the evidence from extensive bioinformatic analyses. Polygenic risk scores were constructed from the summary statistics of LV genome-wide association studies to predict the heart failure events.The study comprised 16 923 European UK Biobank participants (mean age 62.5 years; 45.8% men) without prevalent myocardial infarction or heart failure. We discovered 14 genome-wide significant loci (3 loci each for LV end-diastolic volume, LV end-systolic volume, and LV mass to end-diastolic volume ratio; 4 loci for LV ejection fraction, and 1 locus for LV mass) at a stringent P<1×10-8. Three loci were replicated at Bonferroni significance and 7 loci at nominal significance (P<0.05 with concordant direction of effect) in the MESA study (n=4383). Follow-up bioinformatic analyses identified 28 candidate genes that were enriched in the cardiac developmental pathways and regulation of the LV contractile mechanism. Eight genes (TTN, BAG3, GRK5, HSPB7, MTSS1, ALPK3, NMB, and MMP11) supported by at least 2 independent lines of in silico evidence were implicated in the cardiac morphogenesis and heart failure development. The polygenic risk scores of LV phenotypes were predictive of heart failure in a holdout UK Biobank sample of 3106 cases and 224 134 controls (odds ratio 1.41, 95% CI 1.26 - 1.58, for the top quintile versus the bottom quintile of the LV end-systolic volume risk score).We report 14 genetic loci and indicate several candidate genes that not only enhance our understanding of the genetic architecture of prognostically important LV phenotypes but also shed light on potential novel therapeutic targets for LV remodeling.
TCT-458 In-Hospital Outcomes of Transcatheter Mitral Valve Repair in Rheumatic Mitral Valve Disease
Authors: Ayman Elbadawi, Omar Al-Taweel, Mohamed Omer, Murtaza Mazhar, Gbolahan Ogunbayo, Mohamed Hamed, Islam Elgendy
Journal: Journal of the American College of Cardiology (2019)
Single-cell transcriptomic profiling of the aging mouse brain
Authors: Methodios Ximerakis, Scott L. Lipnick, Brendan T. Innes, Sean K. Simmons, Xian Adiconis, Danielle Dionne, Brittany A. Mayweather, Lan Nguyen, Zachary Niziolek, Ceren Ozek, Vincent L. Butty, Ruth Isserlin, Sean M. Buchanan, Stuart S. Levine, Aviv Regev, Gary D. Bader, Joshua Z. Levin, Lee L. Rubin
Journal: Nature Neuroscience (2019)
Modulating Hedgehog Signaling Reduces MAPK, TGF-β, and Marrow Fibrosis in a Transgenic Mouse Model of JAK2V617F Associated Myeloproliferative Disease
Authors: Parvesh Chaudhry, Mohan Singh, Imran Siddiqi, Casey L. O'Connell, Zhizhuang Joe Zhao, Akil Merchant
Journal: Blood (2017)