AB0627 INTESTINAL BEHCET’S DISEASE: THE CLINICOPATHOLOGY ANALYSIS OF 38 CASES
Authors: Guosheng Wang, LI Xiaomei, LI Xiangpei, LI Chuanying
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background:</h3> Due to the rarity of GI involvement in BD, the diagnosis of intestinal BD relies on a combination of both vasculitis and IBD type characteristics. Histopathology play an important role in differentiation. <h3>Objectives:</h3> To invastigate the clinic features, findings of endoscopy and histopathology of intestinal Behcet's disease. <h3>Methods:</h3> The clinical features, findings of endoscopy and histolopathology of 38 intestinal Behcet's disease were analyzed retrospectively. <h3>Results:</h3> The mean age of 38 cases were 44.1±15.6 years, the mean course were 64.8±90.4 months. Typical clinic manifestations and endoscopic finding existed in 24(63.2%) and 22(57.9%) patients with intestinal Behcet's disease respectively. The most common(33, 86.8%) symptoms were abdominal pain and diarrhea. The sites of intestinal ulcer were seen more often(22, 57.9%) at the ileum, ileocecal area, on the ileocecal valve. Most colonoscopic appearance of ulcers were usually well demarcated, oval or round (28, 73.6%). The suggestive histopathological changes were massive neutrophilic infiltration (20, 52.6%), inflammatory granuloma(14, 36.8%) and vasculitis(8, 21%) especially phlebitis. <h3>Conclusion:</h3> The diagnosis of intestinal Behcet's disease depends on the combination of clinic features, endoscopic appearance and histopathological findings. massive neutrophilic infiltration, inflammatory granuloma and vasculitis point to the possibility of intestinal Behcet's disease. <h3>References</h3> [1] Dong Y, Shi G. The synopsis of the 8th international meeting on BD [J]. Chin Med J, 1999, 38(2):135–136 [2] Davatchi F, assaad Khalil S, Calamia KT, et al. The international Criteria for Behçet's Disease (ICBD) : a collaborative study of 27 countries on the sensitivity and specificity of the new criteria [J]. J Eur acad Dermatol Venereol, 2014, 28 (3):338-347. [3] Cheon JH, Kim ES, Shin SJ, et al. Development and validation of novel diagnostic criteria for intestinal Behçet's disease in Korean patients with ileocolonic ulcers [J]. Am J Gastroenterol, 2009, 104 (10):2492-2499. [4] Valenti S, Gallizzi R, De Vivo D, et al. Intestinal Behçet and Crohn's disease: two sides of the same coin [J]. Pediatric Rheumatology, 2017, 15 (1):33-40. [5] Sakane T, Takeno M, Suzuki N, inaba G. Behcet's disease. N Engl J Med [J]. 1999, 341(17):1284–91. [6] Zhuoli Zhang, Fang He, Yanjun Shi. Behcet's disease seen in China: analysis of 334 cases [J]. Rheumatol int, 2013, 33 (3):645–648 [7] Park J, Cheon JH, Park YE, et al. Risk factors and outcomes of acute lower gastrointestinal bleeding in intestinal Behcet's disease [J]. Int J Colorectal Dis2017, 32(5):745–51. [8] Cheon JH, Kim WH. An update on the diagnosis, treatment, and prognosis of intestinal Behçet's disease [J]. Curr Opin Rheumatol, 2015, 27(1):24–31. [9] Lee SK, Kim BK, Kim TI, et al. Differential diagnosis of intestinal Behcet's disease and Crohn's disease by colonoscopic findings [J]. Endoscopy, 2009, 41(1):9–16. [10] Hayasaki N, Ito M, Suzuki T, et al. Neutrophilic phlebitis is characteristic of intestinal Behcet's disease and simple ulcer syndrome [J]. Histopathology, 2004, 45(4): 377–83. [11] Demirkesen C, Oz B, Göksal S. Behcet's disease: pathology. In: Yazici Y, Yazici H, editors. Behcet's syndrome. New York: Springer; 2010. p. 215–43. <h3>Disclosure of interests:</h3> None declared