tbuckley/cabot-search huggingface dataset:
Abstract 18617: Comparative Evaluation of the Diagnostic Accuracy of Dobutamine Stress Echocardiography Strain Imaging to Detect Ischaemia as Assessed by Fractional Flow Reserve and the Instantaneous Wave-free Ratio
Authors: Daniel Cave, Matthew Shun-Shin, James Howard, Graham Cole, Ravi Assomull, Niall Keenan, Gajen Kanaganayagam, Roland Wensal, Joban Sehmi, David Thompson, Nina Bual, Justin Davies, Darrel Francis, Rasha Al-Lamee
Journal: Circulation (2017)

Introduction: Dobutamine stress echocardiography (DSE) is widely used in clinical practice although it remains subjective. Strain imaging by speckle-tracking echocardiography provides an automated ...
Estrogen metabolites, level of E7, and squamous cell carcinoma antigenin the tissue of cervical cancer.
Authors: Elena Frantsiyants, Ekaterina Komarova, Vera Nikitina, Diana Spiridonova, Nataliya Cheryarina
Journal: Journal of Clinical Oncology (2014)

e22236 Background: The role of cofactors in HPV-dependent cancerogenesis is studied actively. It is supposed that the hormonal balance in the organism is upset due to imbalance in the proportion of main metabolites of estrogens – 2- and 16-hydroxiderivates. Methods: The IFA method was used for studying the content of E7 protein, antigen of squamous cell carcinoma, metabolites of estrogens 2-OHE1 and 16-OHE1 in samples of cervical cancer tissue (g
The Economic Case for the Prevention of Mental Illness
Authors: David McDaid, A-La Park, Kristian Wahlbeck
Journal: Annual Review of Public Health (2019)

Poor mental health has profound economic consequences. Given the burden of poor mental health, the economic case for preventing mental illness and promoting better mental health may be very strong, but too often prevention attracts little attention and few resources. This article describes the potential role that can be played by economic evidence alongside experimental trials and observational studies, or through modeling, to substantiate the need for increased investment in prevention. It illustrates areas of action across the life course where there is already a good economic case. It also suggests some further areas of substantive public health concern, with promising effectiveness evidence, that may benefit from economic analysis. Financial and economic barriers to implementation are then presented, and strategies to address the barriers and increase investment in the prevention of mental illness are suggested.
Abstract 19472: Increased Duration Between LVAD Implantation and Orthotopic Heart Transplantation is Associated With Increased Operative Mortality: An Analysis of the Society of Thoracic Surgeons Adult Cardiac Surgery Database
Authors: Babatunde A Yerokun, Mani A Daneshmand, Maria V Grau-Sepulveda, Michael S Mulvihill, Sreekanth Vemulapalli, Alice Wang, Vinod Thourani, Vinay Badhwar, Jeffrey P Jacobs, Peter K Smith, Jacob Schroder, Gorav Ailawadi, Adam DeVore, Chetan B Patel, Carmelo A Milano
Journal: Circulation (2017)

Background: Potential adverse effects of prolonged reduced pulsatility before orthotopic heart transplantation (OHT) are unknown. We hypothesized longer duration of LVAD support before OHT would be...
Myelodysplastic Syndromes with Hypocellular Marrow: Clinical Characteristics and Evaluation of Outcome
Authors: Valeria Santini, Daniela Maria Gioia, Elisa Masiera, Antonella Poloni, Dario Ferrero, Alberto Fragasso, Carlo Finelli, Flavia Salvi, Gianluca Gaidano, Esther Natalie Oliva, Massimo Catarini, Gianni Cametti, Margherita Bonferroni, Paolo Danise, Rodolfo Tassara, Bernardino Allione, Daniela Cilloni, Andrea Castelli, Riccardo Centurioni, Giorgio Ciravegna, Giuseppe Visani, Pellegrino Musto, Enrico Balleari, Emanuela Boveri, Maurilio Ponzoni, Umberto Gianelli, Matteo Giovanni Della Porta
Journal: Blood (2018)
Future trends in risk of death from cutaneous melanoma.
Authors: Philippe Autier, Alice Koechlin, Mathieu Boniol
Journal: Journal of Clinical Oncology (2014)

e20022 Background: Decreasing trends in cutaneous melanoma mortality are reported in many white populations, starting before the recent advent of more efficient treatments. The objective was to foresee future trends in risks of melanoma death in light-skinned populations. Methods: Using data from the WHO mortality database, age-period models were fitted for broad geographical areas so that optimal statistical power was available for long-term trend analysis. Results: In all light-skinned populations, mortality from melanoma is essentially decreasing in subjects less than 50. Less pronounced decreases are observed in subjects 50-69 years. Mortality is leveling off or still increasing in subjects 70 and more. Strong consistent birth cohort effects are present in populations, ie, risks of dying from melanoma started increasing for subjects born at the end of 19th century. Risks peaked for subjects born in 1930-35 in Oceania, 1937-40 in North America, 1939-40 in Nordic countries, 1941-49 in the UK and Ireland, 1944-53 in Western Europe, and 1958-60 in Central Europe. Steady declines in mortality followed peak periods, starting among youngest subjects and then gradually involving older age groups. In Southern Europe, birth years with maximum risk of melanoma death have not yet been reached. In North America, the lifetime risk to die from melanoma of subjects born from 1990 onwards will be as low that of subjects born before 1890. Period effects appeared to have marginal impact on trends, ie, risks of melanoma death were not influenced by some event starting at a given point in time and affecting all age groups simultaneously. Conclusions: The occurrence of fatal melanoma is strongly variable across successive generations, most probably associated with intense exposure to ultraviolet radiation sources in first years of life, a fashion known to have emerged end of the nineteenth century for reaching a maximum around World War Two, for fading away in more recent decades. Hence, even in the absence of effective screening and treatment, death due to melanoma is likely to become an increasingly rare event. This forecast agrees with suggestions of changes in melanoma aggressiveness over time, and decreasing mortality despite continuing rises in the incidence of advanced melanoma.
Attachment measures in middle childhood and adolescence: A systematic review of measurement properties
Authors: Tom Jewell, Tessa Gardner, Karima Susi, Kate Watchorn, Emily Coopey, Mima Simic, Peter Fonagy, Ivan Eisler
Journal: Clinical Psychology Review (2019)

Attachment theory proposes that humans develop representations of self and other in early childhood which are relatively stable across the life-course, and play a key role in psychological adaptation. However, to date, the psychometric properties of attachment measures in middle childhood and adolescence have not been evaluated in a systematic review. A systematic review (PROSPERO ID: CRD42017057772) was conducted using COSMIN criteria. Two researchers independently searched MEDLINE, PsychINFO and Embase databases for relevant articles. Fifty-four studies were included in the review. The methodological quality of studies was typically fair or poor, with only a small number of studies being rated as of good or excellent quality. The measurement properties of attachment measures in this age group were frequently rated as inadequate according to COSMIN criteria. The Child Attachment Interview (CAI) has the best psychometric properties of the interview and projective measures, and the Inventory of Parent and Peer Attachment (IPPA) the best evidence of the self-report measures. Overall, the evidence for the CAI and IPPA included both positive and negative findings relating to adequacy of measurement properties. Attachment measures in middle childhood and adolescence currently have limited evidence for the adequacy of their psychometric properties.
Association between body mass index and all-cause mortality in colorectal cancer patients: A meta-analysis of prospective cohort studies.
Authors: Junga Lee, Justin Y Jeon, Jeffrey A. Meyerhardt, Edward L. Giovannucci, Ji Young Kim, Ji-Hee Min, Minsuk Oh
Journal: Journal of Clinical Oncology (2014)

3613 Background: Studies have reported conflicting results on association between body mass index (BMI) and colorectal cancer-specific mortality and all-cause mortality in colorectal cancer patients. Methods: We performed a meta-analysis of 13 prospective cohort studies to identify the association between BMI (pre-diagnosis BMI or post-diagnosis BMI) and mortality outcome measures. Random-effects meta-analyses were performed to determine the risk ratio (RR) and 95% confidence interval (CIs). The analysis included 52,278 patients followed up over a period ranging from 4.9 to 20 years (median: 9.9 years). Results: We found that pre-diagnosis underweight was associated with increased all-cause mortality (RR: 1.62, 95% CI: 1.18-2.23, p<0.01) and obesity (BMI ≥ 30 kg/m2) was associated with increased colorectal cancer-specific mortality (RR: 1.20, 95% CI: 1.07-1.36, p<0.01) and all-cause mortality (RR: 1.24, 95% CI: 1.12-1.38, p<0.01). On the other hand, post-diagnosis underweight (RR: 1.33, 95% CI: 1.19-1.47, p<0.01) and class II/III obesity (BMI ≥ 35 kg/m2; RR: 1.13, 95%CI: 1.03-1.14, p<0.01) were associated with significantly increased all-cause mortality. When subgroup analysis according to gender was conducted, post-diagnosis obesity was associated with increased all-cause mortality (RR: 1.131, 95% CI: 1.054-1.213, p<0.01) in women only. Conclusions: Being obese prior to diagnosis of CRC was associated with CRC specific mortality and all-cause mortality, while being underweight and obesity after diagnosis was associated with increased all-cause mortality. Maintaining a normal body weight should be recommended to all individuals including colorectal cancer patients. This study was supported by National Research Foundation of Korea (2013 K2A1A2054437).
The association of prechemotherapy neutorphil-lymphocyte ratio with survival in advanced non-small cell lung cancer patients.
Authors: Ankit Mangla, Romy Thekkekara, Udit Yadav, Roozbeh Mohajer, Thomas E. Lad
Journal: Journal of Clinical Oncology (2014)

e19091 Background: Multiple studies have shown that elevated Neutrophil-lymphocyte ratio (NLR) is associated with aggressive disease and advanced stage in various cancers and as such these patients may represent a high-risk population. We aimed to investigate the association of pre-chemotherapy NLR and other cell counts in stage III/IV Non-Small cell lung cancer (NSCLC) patients with overall survival (OS) at 1-year. Methods: 111 patients with NSCLC were identified from tumor registry of which 75 patients with stage III/IV disease were included in the study. All charts were screened retrospectively for demography, histology, stage, cell counts and OS in months. Patients who died without receiving chemotherapy were excluded from the study. The data was analyzed using descriptive statistics and Cox proportional hazard ratios were calculated. Results: The mean age of the study population was 57.56 ± 8.96 yrs with a male preponderance (56%). 60% of patients were african-americans, 18.7% caucasians and 13.3% were hispanics. Adenocarcinoma was the most common histological diagnosis (86.7%). 69.3% had stage IV disease. The median NLR was 3.71(IQR 2.56, 5.33). In univariate cox regression analysis of pre-chemotherapy counts, increasing lymphocyte count decreased the hazard (HR: 0.39; 95%CI 0.19,0.79; p=0.009) and increasing NLR was associated with increased hazard ratio (HR: 1.17;95%CI 1.063,1.280; p=0.001). Total leukocyte count and neutrophil count were not significantly associated with predicting OS. Adjusting for stage in multivariate Cox analysis NLR remained a significant independent factor (HR: 1.18; 95% CI 1.07,1.31; p=0.001). Conclusions: This study concludes that pre-chemotherapy NLR and lymphocyte count may be utilized in predicting 1 year OS in Stage III/IV NSCLC. Prospective studies are needed to confirm the utility of NLR and Lymphocyte count in predicting OS in advanced NSCLC.
Effect of the distribution of lymph node metastases on outcomes for trimodality-eligible patients with esophageal and esophagogastric junction adenocarcinoma (EAC).
Authors: Hironori Shiozaki, Kazuki Sudo, Roopma Wadhwa, Elena Elimova, Rebecca Slack, Hsiang-Chun Chen, Heath D. Skinner, Ritsuko Komaki, Jeffrey H. Lee, Brian Weston, Manoop S. Bhutani, Mariela A. Blum, Dipen M. Maru, Wayne Lewis Hofstetter, Jaffer A. Ajani
Journal: Journal of Clinical Oncology (2014)

4084 Background: In patients with trimodality-eligible EAC, the presence of malignant nodes at baseline portends a poor prognosis. It is difficult to quantify the number of positive lymph nodes using imaging modalities. For clinical staging, distribution of lymph node metastasis on imaging may be a potential surrogate for number and a useful tool to consider prognosis. We hypothesized that the distribution of baseline nodes (above and/or below the diaphragm) will have a correlation with overall and relapse-free survival. Methods: We identified 209 EAC patients with baseline malignant nodes. All patients underwent trimodality therapy. Patients were grouped based on the presence of (A) nodes above the diaphragm, (B) nodes below the diaphragm, and (C) nodes above and below the diaphragm. Survival estimates were calculated using the Kaplan-Meier method. The differences in OS and RFS among patient subgroups were assessed using log-rank tests. Differences were considered significant if the 2-sided p-value was less than 0.05. Results: The patients were primarily Caucasians (91%), males (93%), and had stage III EAC (89%).The median follow-up was 2.2 years (range, 0.4 to 10.8 years). Of the 209 patients, 35% (73) were in group A, 20% (41) were in group B, and 45% (95) in group C. Patients in group C had the worst 5-year overall survival (33%) compared to those patients in groups A (55%) or B (60%; P=0.02). Patients with high histology grade were also at higher risk of relapse and poor survival outcome (P<0.01 for each). Conclusions: The presence of suspicious or confirmed malignant lymph nodes above and below the diaphragm leads to the worst prognosis for EAC patients undergoing trimodality therapy. Therefore, novel therapeutic strategies are needed for these patients.
A Phase II Study of Nivolumab or Ipilimumab with or without Azacitidine for Patients with Myelodysplastic Syndrome (MDS)
Authors: Guillermo Garcia-Manero, Koji Sasaki, Guillermo Montalban-Bravo, Naval G. Daver, Elias J. Jabbour, Yesid Alvarado, Courtney D. DiNardo, Farhad Ravandi, Gautam Borthakur, Prithviraj Bose, Naveen Pemmaraju, Kiran Naqvi, Jorge E. Cortes, Tapan M. Kadia, Marina Y. Konopleva, Simona Colla, Hui Yang, Caitlin R. Rausch, Yvonne Gasior, Carlos E. Bueso-Ramos, Rashmi Kanagal-Shamanna, Keyur P. Patel, Hagop M. Kantarjian
Journal: Blood (2018)
Short Time between Progression after Immunochemotherapy and Initiation of Salvage Therapy (PTI) Is Associated with Inferior Long-Term Outcomes in Patients with Relapsed/Refractory DLBCL
Authors: Matthew J. Maurer, Umar Farooq, Madison M Wahlen, Thomas M. Habermann, Gita Thanarajasingam, Sergei Syrbu, William R. Macon, Patrick Johnston, Ivana Micallef, Luis Porrata, Susan L. Slager, Stephen M. Ansell, Thomas E. Witzig, James R. Cerhan, Grzegorz S. Nowakowski, Carrie A. Thompson, Brian K. Link
Journal: Blood (2018)
Secondary breast cancer following hematologic malignancies.
Authors: Farah Tanveer, Laurie Ann Ford, Eunice S. Wang, Ellis Glenn Levine, Tracey L. O'Connor, Meir Wetzler
Journal: Journal of Clinical Oncology (2014)

e18014 Background: Hematological malignancies (HM) are treated by chemotherapy, radiotherapy or combination of both. The risk of developing a second malignancy after Hodgkin disease (HD) treatment is high and breast cancer (BC) is the most common malignancy in these patients (pts). However, the incidence of secondary BC after other HM is unclear. We aimed to characterize BC occurring in pts following HM, excluding HD, and to determine if these cancers share any common characteristics. Methods: Pts with diagnosis of HM, excluding HD, and BC using ICD-9 codes were accessed. Institutional review board approval was obtained. Results: There were 14 pts; all Caucasian female. Median age at time of HM diagnosis was 60 (range 42-83) years. Median age at time of BC diagnosis was 67.5 (range 53-86) years. The median time from HM to BC was 7.55 (range 0.2-20) years. The HM included acute myeloid leukemia (6), myelodysplastic syndrome (3), chronic lymphocytic leukemia (CLL; 4) and one with two malignancies: Waldenström macroglobulinemia and CLL. The BC characteristics are shown in the Table. Two of the 14 pts had ductal carcinoma in situ, and BC characteristics were not defined for these two pts. Five pts died at a median of 1.8 (range 0.3-9.5) years and the rest are alive at a median of 6 (range 2-13) years from diagnosis of BC. Interestingly, ten pts had a family history of cancer of which five were positive for BC. Further, five of the pts had additional malignancies including malignant melanoma plus basal cell cancer (1), renal cell plus lung cancer (1), uterine cancer (2) and ovarian cancer (1). Conclusions: Secondary BC pts seem to have more frequent familial cancers and association with other malignancies suggesting a genetic defect. Breast cancer characteristics. Characteristics Patients (N=12) Number % Histology Invasive ductal 11 92 Adenocarcinoma 1 8 Grade 3 4 33 2 6 50 1 2 17 HER2/neu Positive 1 8 Negative 11 92 Hormone receptor ER/PR+ 10 84 ER+/PR- 1 8 ER/PR- 1 8 Clinical stage I 6 50 II 3 25 III 1 8 IV 2 17 Abbreviations: ER, estrogen receptor; N/A, not available; PR, progesterone receptor.
Treatment satisfaction in atopic dermatitis relates to patient‐reported severity: A cross‐sectional study
Authors: T. Nakahara, H. Fujita, K. Arima, Y. Taguchi, S. Motoyama, M. Furue
Journal: Allergy (2018)

TN and MF have nothing to disclose. HF, KA, and SM are employees and may be stockholders of Sanofi K.K. YT is an employee and may be a stockholder of Sanofi K.K., and she is also a councilor of ISPOR (International Society for Pharmacoeconomics and Outcomes Research) Japan. This study was funded by Sanofi K.K. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Dual ATP and pH responsive ZIF-90 nanosystem with favorable biocompatibility and facile post-modification improves therapeutic outcomes of triple negative breast cancer in vivo
Authors: Zhenqi Jiang, Yinjie Wang, Li Sun, Bo Yuan, Yuchen Tian, Lingchao Xiang, Yanying Li, Yong Li, Juan Li, Aiguo Wu
Journal: Biomaterials (2019)
Abstract 14558: Cardiac Resynchronization Therapy Defibrillators: Pre and Postmarket Experience
Authors: Naomi D Herz, David G Strauss, Mary E Ritchey, Zak Loring, Samantha B Jacobs, Henry Silverman, Christopher M Worrall, Jeffrey Kelman, Ileana L Piña, Daniel A Caños
Journal: Circulation (2012)

Introduction In collaboration with the CMS SafeRx Project, FDA aims to build and implement an active surveillance system with administrative and insurance claims data to monitor FDA-regulated produ...
Outcomes for Initial Patient Cohorts with up to 33 Months of Follow-up in the Hgb-206 Phase 1 Trial
Authors: Julie Kanter, John F. Tisdale, Janet L. Kwiatkowski, Lakshmanan Krishnamurti, Markus Y. Mapara, Manfred Schmidt, Alexandra L. Miller, Francis J. Pierciey, Weiliang Shi, Jean-Antoine Ribeil, Mark C. Walters, Alexis A. Thompson
Journal: Blood (2018)
CRISPR/Cas9 Gene-Edited Hematopoietic Stem Cell Therapy for Sickle Cell Disease
Authors: Vionnie W. C. Yu, Yi Liu, Matthew Curran, Pu Zhang, Jennifer Snead, Christian Schmedt, Yi Yang, Victor Guosheng Lin, William R Tschantz, Lisa Quinn, Carsten Russ, Scott Clarkson, Amy Janiak, Morag Stewart, Yanick Mulumba, Reynald Lescarbeau, Brad Murray, Jessica Seitzer, Walter Strapps, Hon-Ren Huang, Kevin Sloan, Craig S Mickanin, Lloyd Klickstein, Susan Stevenson
Journal: Blood (2017)
Incidence of melanoma and outcomes of longitudinal melanonychia in a cohort of cases referred to a London dermatology department
Authors: Z. Jiyad, V. Akhras
Journal: British Journal of Dermatology (2019)

Longitudinal melanonychia is a pigmented longitudinal band on the nail plate and may occur due to melanocyte activation, nail matrix nevus, lentigo or subungual melanoma.1 In a racially diverse community, melanonychia is a relatively common presenting complaint. However, despite this, little is known about the incidence of melanoma in longitudinal melanonychia, as well as variations in management approaches.
Association of Diabetes With Central Corneal Thickness Among a Multiethnic Asian Population
Authors: Xiao-Yang Luo, Wei Dai, Miao-Li Chee, Yijin Tao, Jacqueline Chua, Nicholas Y. Q. Tan, Yih-Chung Tham, Tin Aung, Tien Yin Wong, Ching-Yu Cheng
Journal: JAMA Network Open (2019)

Thicker or thinner central corneas may lead to either overestimation or underestimation of intraocular pressure, which is the most important causal and treatable risk factor for glaucoma. However, the findings on the associations between diabetes, random glucose, and glycated hemoglobin A1c (HbA1c) with central corneal thickness (CCT) are conflicting.To evaluate the associations between diabetes, random glucose, and HbA1c with CCT in a multiethnic Asian population.Cross-sectional analysis of the Singapore Epidemiology of Eye Diseases (SEED) Study conducted from 2004 to 2011. A total of 10 033 Chinese, Malay, and Indian individuals 40 years or older residing in Singapore were recruited. Participants with incomplete information on diabetes status (448 participants), prior refractive or cataract surgery (1940 eyes), and corneal edema or dystrophy (29 eyes) were excluded. A meta-analysis was conducted to estimate the overall association of diabetes with CCT.Standardized clinical examinations and interviewer-administered questionnaire to collect information about demographic, systemic, and ocular factors.Measurement of CCT using ultrasound pachymetry.A total of 8846 adults (mean [SD] age, 57.9 [9.9] years; 4447 women [50.3%]) (17 201 eyes) were included in the final analyses. The CCT profile was similar among participants with and without diabetes (mean [SD] CCT, 545.3 [33.7] μm vs 544.8 [33.9] μm; P = .39). Following adjustments of age, sex, ethnicity, corneal curvature, axial length, and body mass index, CCT was a mean (SD) of 4.9 (0.8) μm (95% CI, 3.3-6.5 μm) thicker in patients with diabetes than those without diabetes. Multivariable analyses also showed that thicker CCT was associated with higher random glucose (per 10 mg/dL [to convert to mmol/L, multiply by 0.0555], β = 0.3; 95% CI, 0.2-0.4) and higher HbA1c (per percentage, β = 1.5; 95% CI, 1.0-2.1) (all P < .001). These associations were significant in the subgroup with diabetes but not in the subgroup without diabetes. A meta-analysis including 12 previous population- and clinical-based studies showed that CCT was 12.8 μm (95% CI, 8.2-17.5 μm) thicker in eyes of patients with diabetes.These findings suggest that diabetes and hyperglycemia were associated with thicker CCT. This study provides useful information on the interpretation of intraocular pressure in patients with diabetes.