tbuckley/cabot-search huggingface dataset:
Genetic and Response-Based Risk Classification Identifies a Subgroup of NCI High Risk Childhood B-Lymphoblastic Leukemia (HR B-ALL) with Outstanding Outcomes: A Report from the Children's Oncology Group (COG)
Authors: Elizabeth Raetz, Mignon L. Loh, Meenakshi Devidas, Kelly Maloney, Eric C. Larsen, Leonard A. Mattano, Michael J. Borowitz, Brent L Wood, Andrew J. Carroll, Nyla A. Heerema, I-Ming Chen, Alison M. Friedmann, Kirk R. Schultz, Mary V. Relling, Richard C Harvey, Julie Gastier-Foster, Cheryl L. Willman, Naomi J. Winick, Stephen P Hunger, William L. Carroll
Journal: Blood (2015)
Analysis Of 402 Cord Blood Units To Assess Factors Influencing Infused Viable CD34+ Cell Dose: The Critical Determinant Of Engraftment
Authors: Duncan Purtill, Katherine M Smith, Joann Tonon, Katherine L Evans, Marissa N Lubin, Courtney Byam, Doris M Ponce, Andromachi Scaradavou, Cladd E Stevens, Juliet N Barker
Journal: Blood (2013)
the Development and Expansion of Resistant Subclones Precedes Relapse during Ibrutinib Therapy in Patients with CLL
Authors: Jennifer A. Woyach, Daphne Guinn, Amy S. Ruppert, James S. Blachly, Arletta Lozanski, Nyla A. Heerema, Weiqiang Zhao, Joshua Coleman, Daniel Jones, Lynne V. Abruzzo, Amber Gordon, Rose Mantel, Lisa L. Smith, Samantha McWhorter, Melanie Davis, Tzyy-Jye Doong, Fan Ny, Margaret S. Lucas, Weihong Chase, Jeffrey Jones, Joseph M. Flynn, Kami J. Maddocks, Samantha Jaglowski, Leslie A. Andritsos, Farrukh T. Awan, Kristie Blum, Michael R. Grever, Gerard Lozanski, John C. Byrd, Amy J. Johnson
Journal: Blood (2016)
Differences in Alloimmunity to Erythrocytes Between Korea and Japan; Cooperative International Study of Alloimmunity to Antigen Diversity in Asian Populations,
Authors: Harumi Fujihara, Akihiro Takeshita, Dae Won Kim, Kyou Sup Han, So-Yong Kwon, Seog Woon Kwon, Jang Soo Suh, Hiroko Watanabe, Makoto Uchikawa, Shuichi Kino, Kenneth E Nollet, Hitoshi Ohto
Journal: Blood (2011)
Loss of RAF Kinase Inhibitor Protein Is a Frequent Event In Acute Myeloid Leukemia with a Monocytic Phenotype and Cooperates with Mutant RAS In Malignant Transformation
Authors: Armin Zebisch, Albert Woelfler, Karin Hiden, Claudia Bodner, Franz Quehenberger, Astrid Drasche, Daniela Pirkebner, Martina Haller, Oliver Rath, Karen Blyth, Erdogan Taskesen, Walter Kolch, Jakob Troppmair, Heinz Sill
Journal: Blood (2010)
Use of the Dana-Farber/CIBMTR Disease Risk Index (DRI) to Compare Outcomes of T-Replete HLA-Haploidentical Transplants Using Post-Transplant Cyclophosphamide to Matched Sibling and Matched Unrelated Donor Transplants : A Multivariate Analysis of 498 Contemporaneous Allogeneic Transplants from a Single Center
Authors: Asad Bashey, Xu Zhang, Stacey Brown, Katelin Connor, Lawrence E. Morris, H. Kent Holland, Scott R. Solomon
Journal: Blood (2014)
Intratumoral delivery of RIG-I agonist SLR14 induces robust antitumor responses
Authors: Xiaodong Jiang, Viswanathan Muthusamy, Olga Fedorova, Yong Kong, Daniel J. Kim, Marcus Bosenberg, Anna Marie Pyle, Akiko Iwasaki
Journal: The Journal of Experimental Medicine (2019)

Cytosolic nucleic acid–sensing pathways can be triggered to enhance immune response to cancer. In this study, we tested the antitumor activity of a unique RIG-I agonist, stem loop RNA (SLR) 14. In the immunogenic tumor models, we observed significant tumor growth delay and an extended survival in SLR14-treated mice. SLR14 also greatly improved antitumor efficacy of anti-PD1 antibody over single-agent treatment. SLR14 was mainly taken up by CD11b+ myeloid cells in the tumor microenvironment, and many genes associated with immune defense were significantly up-regulated after treatment, accompanied by increase in the number of CD8+ T lymphocytes, NK cells, and CD11b+ cells in SLR14-treated tumors. Strikingly, SLR14 dramatically inhibited nonimmunogenic B16 tumor growth, and the cured mice developed an immune memory. Furthermore, a systemic antitumor response was observed in both bilateral and tumor metastasis models. Collectively, our results demonstrate that SLR14 is a promising therapeutic RIG-I agonist for cancer treatment, either alone or in combination with existing immunotherapies.
New US Myeloma Registry (Connect MM® – The Multiple Myeloma Disease Registry): Features of Newly Diagnosed Patients In 2010
Authors: Brian G. M. Durie, Jatin J. Shah, Rafat Abonour, Cristina Gasperetto, Jayesh Mehta, Chris L. Pashos, Kathleen Toomey, Mohit Narang, Howard Terebelo, Fernando Camacho, Arlene S. Swern, Thomas K. Street, Kristen A. Sullivan, Robert M. Rifkin
Journal: Blood (2010)
Response to: ‘Ultrasonographic damages of major salivary glands are associated with cryoglobulinemic vasculitis and lymphoma in primary Sjogren’s syndrome: are the ultrasonographic features of the salivary glands new prognostic markers in Sjogren's syndrome?’ by Coiffier <i>et al</i>
Authors: Sandrine Jousse-Joulin, Maria Antonietta D'Agostino, Alojzija Hočevar, Esperanza Naredo, Lene Terslev, Sarah Ohrndorf, Annamaria Iagnocco, Wolfgang A Schmidt, Stephanie Finzel, Zarrin Alavi, George A W Bruyn
Journal: Annals of the Rheumatic Diseases (2019)

We thank Dr Coiffier and colleagues for their interesting letter in which they suggest that damages of major salivary glands (SG) might be associated with cryoglobulinemic vasculitis and lymphoma in primary Sjogren’s syndrome. The authors raise the question whether the ultrasonographic (US) features of the salivary glands [our proposed novel ultrasound scoring system] could be used as the new prognostic markers for cryoglobulinemic vasculitis and lymphoma in patients with Sjogren’s syndrome.1

In their recent study of different US scoring systems in 97 sicca syndrome patients, Coiffier et al found three B-cell lymphomas in the primary Sjogren’s syndrome (pSS) group and three, two, and one patient with …
A Refined Clinical Risk Score at Onset of Treatment for Acute Gvhd That Predicts Response to Initial Therapy, Survival and Transplant-Related Mortality
Authors: Margaret L. MacMillan, Marie Robin, Andrew C Harris, Todd E. Defor, Paul J. Martin, Amin Alousi, Vincent T Ho, Javier Bolanos-Meade, James L.M. Ferrara, Richard J. Jones, Mukta Arora, Bruce R. Blazar, Shernan G. Holtan, David Jacobsohn, Marcelo C. Pasquini, Gerard Socie, Joseph H. Antin, John E. Levine, Daniel J. Weisdorf
Journal: Blood (2014)
Recombinant Factor VIIa Reverses the Anticoagulant Effects of Argatroban, Bivalirudin, Fondaparinux, Enoxaparin, and Heparin as Assessed Ex Vivo by Thromboelastography.
Authors: Guy Young, Karyn E. Yonekawa, Peggy Nakagawa, Rachelle Blain, Amy E. Lovejoy, Diane J. Nugent
Journal: Blood (2004)
Single Cell Profiling of B Cell Receptor Signaling and Apoptosis Networks in Chronic Lymphocytic Leukemia: Association with in Vitro Sensitivity to Fludarabine Monophosphate (F-ara-A).
Authors: Erik Evensen, Adam Palazzo, Ying-Wen Huang, Alessandra Cesano, Laura Z. Rassenti, Thomas J. Kipps, Wendy J. Fantl
Journal: Blood (2009)
The Novel HDAC Inhibitor UCL67022 Is Highly Potent in Multiple Myeloma and Non-Hodgkin’s Lymphoma and Is Enhanced by Bortezomib.
Authors: Lenushka Maharaj, Rakesh Popat, Angela Chahwan, Andrew T. Lister, James D. Cavenagh, Brian Middleton, Alf Rioja, Charles Marson, Simon P. Joel
Journal: Blood (2006)
Transfuse Neonates with Cord Blood-Derived Red Blood Cells: A Feasibility Study to Assess Allogeneic Cord Blood Unit Fractionation and Validation
Authors: Maria Bianchi, Luciana Teofili, Carmen Giannantonio, Alessandra Landini, Patrizia Papacci, Maria Fioretti, Costantino Romagnoli, Gina Zini
Journal: Blood (2012)
A Novel STAT3 Inhibitor Has Potent Activity in Preclinical Models of Acute Myeloid Leukemia That Incorporate the Stromal Environment
Authors: Michael J Krueger, Matthew Minus, Wei Liu, Xin Long, Alexandra M. Stevens, Mikhail I. Kolosov, Edward Allan R. Sison, David John Tweardy, Zachary T. Ball, Michele S. Redell
Journal: Blood (2015)
Amplification of AML1 Does Not Impact Early Outcome of Children with Acute Lymphoblastic Leukemia (ALL) Treated with Risk-Directed Chemotherapy: A Report From the Children's Oncology Group (COG).
Authors: Nyla A. Heerema, Andrew J. Carroll, Michael J. Borowitz, Meenakshi Devidas, Eric C. Larson, Mignon Loh, Leonard A. Mattano, Kelly Maloney, Elizabeth Raetz, Brent Wood, Naomi J. Winick, Stephen P Hunger, William L. Carroll
Journal: Blood (2009)
Effect of Related and Unrelated Donor Haemopoietic Stem-Cell Transplantation on Outcome In Adults with High Risk Acute Leukemia: An Intention-to-Treat Analysis at a Single Center Institution
Authors: Maria Teresa Lupo-Stanghellini, Magda Marcatti, Milena Coppola, Barbara Forno, Cinzia Bitetti, Elisa Sala, Andrea Assanelli, Raffaella Greco, Francesca Lunghi, Alessandro Crotta, Michela Tassara, Valeria Calbi, Francesca Matteazzi, Elena Guggiari, Matteo Carrabba, Lionello Camba, Daniela Clerici, Simona Malato, Sarah Marktel, Katharina Fleischhauer, Chiara Bonini, Claudio Bordignon, Consuelo Corti, Massimo Bernardi, Jacopo Peccatori, Fabio Ciceri
Journal: Blood (2010)
Renal Response in Patients (Pts) with Relapsed Refractory Multiple Myeloma (RRMM): Interim Data of a Large Observational, Prospective Study
Authors: Javier de la Rubia, Enrique Morales, Fernando Escalante, Mª Soledad Durán, Manuel Perez Encinas, Merche Gironella, Tomas J Gonzalez-Lopez, Ignacio Español, Josep Sarrà, Elena Cabezudo, Esther Gonzalez, Carmen Calle, Rafael Martinez, Mario Arnao, Yolanda González, José Antonio Márquez, Valentin Cabañas, Joan Blade, Antonio Ruiz Boza, Antonio Garcia
Journal: Blood (2014)
Incidence, Risk Factors and Outcome of Late Onset Noninfectious Pulmonary Complications after Allogeneic Hematopoietic Stem Cell Transplantation: A Prospective Cohort Study
Authors: Anne Bergeron, Sylvie Chevret, Regis Peffault De La Tour, Karine Chagnon, Cedric De Bazelaire, Frédéric Rivière, Marie Robin, Jean Mani, Gwenael Lorillon, Socié Gérard, Abdellatif Tazi
Journal: Blood (2016)
Molecular Profile and FDG-PET/CT Metabolic Tumor Volume Improve Risk Classification at Diagnosis for Patients with Diffuse Large B Cell Lymphoma
Authors: Anne-Ségolène Cottereau, Hélène Lanic, Michel Meignan, Pierre Vera, Hervé Tilly, Fabrice Jardin, Stéphanie Becker
Journal: Blood (2015)
Characteristics and Effectiveness of Rituximab (R) Maintenance Regimens Among US Patients Diagnosed with Follicular Lymphoma (FL) 2004–2007,
Authors: Loretta Nastoupil, Rajni Sinha, Michelle Byrtek, Xiaolei Zhou, Michael Taylor, James R Cerhan, Jonathan Friedberg, Brian K Link, Jamie H. Hirata, Christopher R Flowers
Journal: Blood (2011)
5-Azacytidine Prevents Relapse from Discrete Bone Marrow Sites in Leukemia Xenografts Treated with CD22-Targeting Immunotoxin Moxetumomab Pasudotox
Authors: Fabian Mueller, Tyler Cunningham, Stephanie Stookey, Chin-Hsien Tai, Alan S. Wayne, Ira Pastan
Journal: Blood (2016)
Significance of Clinical Factors As Prognostic Indicators for Mature T-Cell Non-Hodgkin Lymphoma Patients: A Retrospective Analysis of Chinese Cases
Authors: Wanzhuo Xie, Keyue Hu, Fan Xu, De Zhou, Weijia Huang, Li Li, Jingsong He, Jimin Shi, Yi Luo, Jingjing Zhu, Guoqing Wei, Jie Zhang, Maofang Lin, Xiujin Ye, Zhen Cai, He Huang
Journal: Blood (2012)
The Long Noncoding RNA Paupar Modulates PAX6 Regulatory Activities to Promote Alpha Cell Development and Function
Authors: Ruth A. Singer, Luis Arnes, Yi Cui, Jiguang Wang, Yuqian Gao, Michelle A. Guney, Kristin E. Burnum-Johnson, Raul Rabadan, Charles Ansong, Galya Orr, Lori Sussel
Journal: Cell Metabolism (2019)
Resveratrol Enhances NKG2D-Mediated Cytotoxicity Against Leukemia Cells by Upregulating Both NKG2D Receptor on NK Cells As Well As NKG2D Ligands on Target Cells,
Authors: Luis J. Espinoza, Akiyoshi Takami, Katsuya Nakata, Ly Quoc Trung, Kayoko Yamada, Saki Touda, Shinji Nakao
Journal: Blood (2011)
Safety, Feasibility and Efficacy of High Dose Ranimustine (MCNU), Carboplatin, Etoposide, and Cyclophosphamide (MCVC) Therapy Followed by Autologous Stem Cell Transplantation for Malignant Lymphoma.
Authors: Yoshihiro Kameoka, Naoto Takahashi, Kenichi Ishizawa, Kazunori Murai, Yuichi Kato, Hideyoshi Noji, Jugo Ito, Makoto Hirokawa, Katsusi Tajima, Tsutomu Shichishima, Yoji Ishida, Hideo Harigae, Kenichi Sawada
Journal: Blood (2010)
Requirement of the E2F3 Transcription Factor for BCR/ABL Leukemogenesis.
Authors: Anna M. Eiring, Paolo Neviani, Ramasamy Santhanam, Joshua J. Oaks, Ji Suk Chang, Carlo Gambacorti-Passerini, Stefano Volinia, Guido Marcucci, Michael A. Caligiuri, Gustavo W. Leone, Danilo Perrotti
Journal: Blood (2007)
Is Serial Monitoring of Myeloid Mutations Clinically Relevant in Myelodysplastic Syndromes (MDS): A Report on Behalf of the MDS Clinical Research Consortium (CRC)
Authors: Sangmin Lee, John Barnard, Amy E. DeZern, Jaroslaw P Maciejewski, Najla Alali, David P. Steensma, Ellen K. Ritchie, Pinkal Desai, Guillermo Garcia-Manero, Fatima Ali, Nicole Rizzo, Duane C Hassane, Rami S. Komrokji, Mikkael A. Sekeres, Gail J. Roboz
Journal: Blood (2016)
High-Dose Immunosuppressive Therapy (HDIT) for Severe Systemic Sclerosis (SSc): Long-Term Survivors Show Continued Improvement of Function and Skin with Stability in the Lungs.
Authors: Peter McSweeney, Daniel Furst, Leslie Crofford, Kevin McDonagh, Keith Sullivan, Mayes Maureen, Nelson Lee, Theodore Gooley, Jan Storek, Leona Holmberg, C.S. Chen, Mark Wener, Julie Lee, Gretchen Henstorf, Muneer Abidi, Philip Mease, Richard Nash
Journal: Blood (2004)
A Biomarker Obtained From Whole Peripheral Blood Predicts Response to Bortezomib: Results of a Multicenter Prospective Clinical Study of Multiple Myeloma in Japan.
Authors: Takashi Watanabe, Masato Mitsuhashi, Morihiko Sagawa, Kenshi Suzuki, Masaki Ri, Masahiro Abe, Ken Ohmachi, Yasunori Nakagawa, Shingen Nakamura, Mizuki Chosa, Shinsuke Iida, Masahiro Kizaki
Journal: Blood (2012)
The p53-MDM2 Antagonist RG7388 Activates p53 and Induces a Predominantly Pro-Apoptotic Gene Expression Signature in Chronic Lymphocytic Leukemia
Authors: Carmela Ciardullo, Laura Woodhouse, Erhan Aptullahoglu, Jonathan P Wallis, Helen J Marr, Scott R Marshall, Nick Bown, Elaine Willmore, John Lunec
Journal: Blood (2016)
Nivolumab + chemotherapy vs chemotherapy in EGFR-mutated NSCLC after 1L or 2L EGFR-TKIs (CheckMate 722)
Authors: Keunchil Park, James Chih-Hsin Yang, Nicolas Girard, Tony Mok, Justin Gainor, Kazuhiko Nakagawa, Yi-Long Wu, Wanning Xu, Rong Yang, Yuichiro Ohe
Journal: Annals of Oncology (2019)
FT-1101: A Structurally Distinct Pan-BET Bromodomain Inhibitor with Activity in Preclinical Models of Hematologic Malignancies
Authors: David S Millan, Monica A Alvarez Morales, Kenneth J Barr, Daniel Cardillo, Alan Collis, Christopher J Dinsmore, Jaime A Escobedo, Kevin P Foley, Torsten Herbertz, Stephen Hubbs, Goss S Kauffman, Katherine J Kayser-Bricker, Mark T Kershaw, George P Luke, Matthew W Martin, Crystal McKinnon, Rachel L Mendes, Kristina R Muskiewicz, Shawn ER Schiller, Patricia Soulard, Adam C Talbot, Duncan Walker, Lili Yao, Grace L Williams
Journal: Blood (2015)
Germline MPLW515R Mutation in a Family with Isolated Thrombocytosis
Authors: Mathias Vilaine, Victor Gourain, Cédric Cleyrat, Delphine Feron, Francois Girodon, Nadine Morineau, Ashot Harutyunyan, Robert Kralovics, Sylvie Hermouet
Journal: Blood (2012)
Interdependency Between TP53 Mutations, Cytogenetics, Genetic Instability and Prognosis in MDS and Secondary AML
Authors: Roxana Schaab, Christina Ganster, Sascha Dierks, Katayoon Shirneshan, Marc Talló Parra, Roman Martin, Ulrich Germing, Uwe Platzbecker, Frank Lange, Nicolaus Kroeger, Konstanze Döhner, Bertram Glass, Maike Nickelsen, Reingard Stuhlmann, Lorenz H. Truemper, Julie Schanz, Ulrike Bacher, Detlef Haase
Journal: Blood (2016)
Three Biomarker Panel at Day 7 and 14 Can Predict Development of Grade II-IV Acute Graft-Versus-Host Disease
Authors: Sophie Paczesny, Thomas Braun, Mark Vander Lugt, Andrew Harris, Bryan Fiema, James Hernandez, Sung Choi, Carrie Kitko, John Magenau, Gregory Yanik, Edward M. Peres, Attaphol Pawarode, Shin Mineishi, Joel Whitfield, Dawn Jones, Daniel Couriel, Pavan Reddy, Samir Hanash, James L.M. Ferrara, John E. Levine
Journal: Blood (2010)
A transcutaneous carbon dioxide monitor is a useful tool with known caveats
Authors: Mauro Maniscalco, Salvatore Fuschillo
Journal: European Respiratory Journal (2019)

<b>Although transcutaneous carbon dioxide measurement cannot completely replace conventional blood gas analysis, transcutaneous carbon dioxide sensors could be used in patients with variable levels of hypercapnia also in an acute setting</b>http://bit.ly/2kliEXx
Human Bone Marrow-Derived Mesenchymal Stem Cells Do Not Undergo Transformation after Long-Term In Vitro Culture and Do Not Exhibit Telomere Maintenance Mechanisms.
Authors: Maria Ester Bernardo, Angela Cometa, Raffaella Villa, Francesca Novara, Antonia Moretta, Antonia Avanzini, Rita Maccario, Maria Grazia Daidone, Nadia Zaffaroni, Orsetta Zuffardi, Franco Locatelli
Journal: Blood (2007)
Hyperkalemia and Treatment With RAAS Inhibitors During Acute Heart Failure Hospitalizations and Their Association With Mortality
Authors: Joost C. Beusekamp, Jasper Tromp, John G.F. Cleland, Michael M. Givertz, Marco Metra, Christopher M. O’Connor, John R. Teerlink, Piotr Ponikowski, Wouter Ouwerkerk, Dirk J. van Veldhuisen, Adriaan A. Voors, Peter van der Meer
Journal: JACC Heart Failure (2019)
Increased Copy Number of Interleukin-6 Receptor Gene Is Associated with Adverse Survival In Multiple Myeloma Patients Treated with Autologous Stem Cell Transplantation
Authors: Seon Young Kim, Hyun Jung Min, Hyun Kyung Park, Bora Oh, Tae Young Kim, Hyun Kyung Kim, Inho Kim, Sung-Soo Yoon, Seonyang Park, Byoung Kook Kim, Dong Soon Lee
Journal: Blood (2010)
Abstract 11141: Long-term Clinical Outcomes after Endovascular Therapy for Patients with Critical Limb Ischemia due to Isolated Below the Knee Lesions
Authors: Osamu Iida, Yoshimitsu Soga, Keisuke Hirano, Daizo Kawasaki, Kenji Suzuki, Yusuke Miyashita, Shinsuke Nanto, Masaaki Uematsu
Journal: Circulation (2011)

Background: Long-term clinical outcomes after endovascular therapy (EVT) for patients with critical limb ischemia (CLI) due to isolated below the knee (BTK) lesions have not yet been systematically...
Hippo Pathway (HP) Activity In Acute Myelogenous Leukemia (AML): Different Prognostic Implications Of TAZ versus YAP Inactivation By Phosphorylation
Authors: Steven M. Kornblau, Chenyu W Hu, Yi Hua Qiu, Suk Young Yoo, Nianxiang Zhang, Tapan M. Kadia, Alessandra Ferrajoli, Kevin R. Coombes, Amina A Qutub
Journal: Blood (2013)
P16.21 Medulloblastoma in adult: a case report and literature review
Authors: L. Santos Cardoso, R. Malcata Nogueira
Journal: Neuro-Oncology (2017)

Introduction: Medulloblastoma is an embryonic tumor mainly located at the level of structures derived from the myelencephalon. It is the most common malignant tumor in children with a prevalence of 15-20% of intracranial tumors. In adult constitutes less than 1% of encephalic tumors. Method: The authors report a case of a 34 years old woman, who started complaining of occipital headache with morning predominance that prompted several visits to general emergency, with no other focal neurological signs. The clinical and imagiological investigation revealed a left cerebellar hemisphere lesion with about 40 mm larger diameter, heterogeneous signal capture T2, with apparent implantation base on the tentorium and edema that determinated partial collapse of the IV ventricle. Meningioma, pilocytic astrocytoma, glioma, cerebellar abscess, hemangioblastoma and metastasis were considered in the diferential diagnosis. The patient underwent total excision of well-defined contours lesion with lower tentorial insertion. Results: Pathological examination was consistent with medulloblastoma with neuronal and glial differentiation, IV grade (WHO classification). Postoperatively she presented loca haematoma with associated edema, conditioning acute hydrocephalus. The patient was reoperated with hematoma drainage and placement of external ventricular drainage. She has a follow-up of 2 years, with no evidence of recurrence or tumor dissemination. Karnofski performance score of 100% Conclusions: Although Medulloblastoma is a relatively rare brain lesion it should be considered in the differential diagnosis of posterior fossa tumors. The diagnosis is histological only and in cases of a high grade lesions maximum excision is indicated, once complete recession is the strongest good prognostic factor in this pathology.
Overexpression of Cysteine and Glycine-Rich Protein 2 in Bone Marrow As a Novel Biomarker in Adult B-Cell Acute Lymphoblastic Leukemia
Authors: Shu-Juan Wang, Wei-Min Wang, Wen-Yi Lu, Ya-Zhen Qin, Yue-Yun Lai, Yan-Rong Liu, Xiao-Jun Huang, Kai-Yan Liu, Guo-Rui Ruan
Journal: Blood (2016)
The Histone Deacetylase Inhibitor Panobinostat (LBH-589) Exerts Anti-Leukaemic Activity in a MLL-Rearranged ALL Xenograft Mouse Model
Authors: Patricia Garrido Castro, Eddy HJ Van Roon, Sandra S Mimoso Pinhancos, Pauline Schneider, Mark JB Kerstjens, Merel Willekes, Rob Pieters, Ronald Stam
Journal: Blood (2014)
A Phase I Study Using Single Agent Birinapant in Patients with Relapsed Myelodysplastic Syndrome and Acute Myelogenous Leukemia
Authors: Noelle V. Frey, Selina Luger, James Mangan, Alexis Zebrowski, Alison W. Loren, Hans Minderman, John Baird, David L Porter, Elizabeth O. Hexner, Anita J. Kumar, Marlise R. Luskin, Alexander E Perl, Martin Carroll
Journal: Blood (2014)
Lower Ferritin Concentrations Are Associated with Decreased Hemolysis in Sickle Cell Disease Children without Iron Overload.
Authors: Oswaldo L Castro, Mehdi Nouraie, Lori Luchtman-Jones, Xiaomei Niu, Caterina Minniti, Andrew D. Campbell, Sohail R Rana, Gregory J. Kato, Mark Gladwin, Victor R. Gordeuk
Journal: Blood (2009)
Effect of diet-induced obesity on the efficacy of colon cancer treatment in mice.
Authors: Michael W Greene, Nischala Ammannagari, Erin Gillaspie, Christine M. Burrington, Melissa J Horsman, Anush V. Patel
Journal: Journal of Clinical Oncology (2013)

e14632 Background: Obesity has reached epidemic proportions globally. Colon cancer is one of the leading causes of cancer related deaths in United States and obesity is associated with one-third of incidence of colon cancer. Obesity is also associated with a worse prognosis of colon cancer. However, the mechanistic details are unknown and animal models to investigate human colon cancer in the setting of obesity are lacking. Therefore, we developed a diet-induced animal model of obesity to determine whether obesity alters the efficacy of a standard colon cancer therapeutic, 5-Fluorouracil, in mice with human colon cancer xenografts. Methods: Male Rag1 mice were placed on a High Fat Western Diet (HFWD) or a Low Fat Western Diet (LFWD) for up to 12 weeks. Body weight, biochemical parameters, and glucose and insulin tolerance were measured. To determine the efficacy of 5-Fluorouracil on human colon cancer xenograft growth, Rag1 mice were fed a LFWD or HFWD for 8 weeks and then implanted with tissue-isolated HT-29 human colon cancer tumors. After 3 weeks of tumor growth, the mice were randomly assigned to a drug (5-Flurouracil 40 mg/kg) or control (normal saline) treatment group. Tumor growth was monitored for 14 days. Results: Significant differences in body weight, and glucose and insulin tolerance were observed in the four week HFWD fed mice. Obesity, glucose intolerance, and insulin resistance were more pronounced in 8 and 12 week fed HFWD mice. Estimated HT-29 human colon cancer tumor growth was significantly greater in obese HFWD fed mice compared to lean LFWD fed mice. Treatment with 5-Fluorouracil significantly reduced HT-29 human colon cancer tumor growth in lean LFWD fed mice but was without effect in obese HFWD fed mice. Conclusions: In conclusion, our findings demonstrate that diet induced obesity impairs the efficacy of 5-Fluorouracil in an obese animal model of human colon cancer. Given that obesity is growing exponentially worldwide, more studies to understand the mechanistic links between obesity and various cancers are required.