tbuckley/cabot-search huggingface dataset:
Asymptomatic Blood Donor with a False Positive HTLV-III Western Blot
Authors: M S Saag, J Britz
Journal: New England Journal of Medicine (1986)

This letter describes a case of a false positive Western blot test for antibodies to human T-lymphotropic virus type III (HTLV-III) in an asymptomatic blood donor.  5 repeat enzyme-linked immunosorbent assays (ELISAs) and 1 Western blot provided positive results in this patient a 34-year old woman from rural Alabama who donated blood in 1985.  On clinical evaluation the patient was asymptomatic and her physical examination was normal.  Her T4:T8 ratio was 2.1:1 with a normal lymphocyte count.  Her husband and son were antibody negative by ELISA.  Both the patient and her husband denied any homosexual extramarital sexual encounters intravenous drug abuse blood transfusions or foreign travel.  More blood was drawn from the patient and sent to 3 laboratories for further testing.  Western blot radioimmunoprecipitation and virus isolation studies were all negative.  ELISAs were then repeated in 2 laboratories again with positive results.  However when an unlicensed procedure that controls for nonspecific reactions with H9 cellular material was used strong reactivity was also noted on the control plate.  Further testing of this sample on an indirect fluorescent antibody test for HTLV-III failed to demonstrate the large cell fluorescent pattern typical of HTLV-III-specific serum but identified antimitochondrial antibodies in the patients serum.  The presence of these antibodies in serum as well as antibodies to nuclear antigens human leukocyte antigens and human T-cell antigens has been correlated with false reactivity on ELISAs.  When patients present with negative clinical histories and positive serologic tests the possibility of false positive test results should be strongly considered.  Needed are improved confirmatory tests as well as access to these tests.
Abstract 17804: In Vivo Serial Assessment of Angiotensin II Receptor Blocker and Statin for Stabilizing High-Risk Plaques Using OCT-NIRF Structural-Molecular Integrative Imaging
Authors: Jae Joong Lee, Hyeong Soo Nam, Hyun-Sang Park, Joon Woo Song, Dong Joo Oh, Kyeongsoon Park, Wang-Yuhl Oh, Hongki Yoo, Jin Won Kim
Journal: Circulation (2017)

Introduction: Although angiotensin II receptor blockers (ARBs) and Statins are known as plaque stabilizers with anti-inflammatory effects, the in vivo evidence is lacking in coronary arteries. In t...
An eye on the dog as the scientist's best friend for translational research in ophthalmology: Focus on the ocular surface
Authors: Lionel Sebbag, Jonathan P. Mochel
Journal: Medicinal Research Reviews (2020)

Preclinical animal studies provide valuable opportunities to better understand human diseases and contribute to major advances in medicine. This review provides a comprehensive overview of ocular parameters in humans and selected animals, with a focus on the ocular surface, detailing species differences in ocular surface anatomy, physiology, tear film dynamics and tear film composition. We describe major pitfalls that tremendously limit the translational potential of traditional laboratory animals (i.e., rabbits, mice, and rats) in ophthalmic research, and highlight the benefits of integrating companion dogs with clinical analogues to human diseases into preclinical pharmacology studies. This One Health approach can help accelerate and improve the framework in which ophthalmic research is translated to the human clinic. Studies can be conducted in canine subjects with naturally occurring or noninvasively induced ocular surface disorders (e.g., dry eye disease, conjunctivitis), reviewed herein, and tear fluid can be easily retrieved from canine eyes for various bioanalytical purposes. In this review, we discuss common tear collection methods, including capillary tubes and Schirmer tear strips, and provide guidelines for tear sampling and extraction to improve the reliability of analyte quantification (drugs, proteins, others).
IRF5 guides monocytes toward an inflammatory CD11c <sup>+</sup> macrophage phenotype and promotes intestinal inflammation
Authors: Alastair L. Corbin, Maria Gomez-Vazquez, Dorothée L. Berthold, Moustafa Attar, Isabelle C. Arnold, Fiona M. Powrie, Stephen N. Sansom, Irina A. Udalova
Journal: Science Immunology (2020)

The transcription factor IRF5 promotes macrophage differentiation in Helicobacter -driven intestinal inflammation in mice.
Homeostasis as a proportional–integral control system
Authors: Lennaert van Veen, Jacob Morra, Adam Palanica, Yan Fossat
Journal: npj Digital Medicine (2020)

Abstract According to medical guidelines, the distinction between “healthy” and “unhealthy” patients is commonly based on single, discrete values taken at an isolated point in time (e.g., blood pressure or core temperature). Perhaps a more robust and insightful diagnosis can be obtained by studying the functional interdependence of such indicators and the homeostasis that controls them. This requires quasi-continuous measurements and a procedure to map the data onto a parsimonious control model with a degree of universality. The current research illustrates this approach using glucose homeostasis as a target. Data were obtained from 41 healthy subjects wearing over-the-counter glucose monitors, and projected onto a simple proportional–integral (PI) controller, widely used in engineering applications. The indicators quantifying the control function are clustered for the great majority of subjects, while a few outliers exhibit less responsive homeostasis. Practical implications for healthcare and education are further discussed.
97O PREDIX HER2 trial: Event-free survival and pathologic complete response in clinical subgroups and stromal TILs levels
Authors: T. Hatschek, A. Andersson, J. Bjöhle, A. Bosch, L. Carlsson, A.C. Dreifaldt, Z. Einbeigi, E. Elinder, H. Fredholm, E. Isaksson-Friman, M. Hellström, H. Johansson, T. Lekberg, H. Lindman, I. Zerdes, T. Foukakis, J. Hartman, Y. Brandberg, J. Bergh
Journal: Annals of Oncology (2020)
Dehydropeptidase 1 Promoted Survival and Cell Cycle Progression through Regulation of CREB and P53 Pathways in B-Cell ALL
Authors: Jia-Min Zhang, Shu-Juan Wang, Wen-Yi Lu, Jiao Zhou, Jing Zhang, Xiao-Jun Huang, Kai-Yan Liu, Guorui Ruan
Journal: Blood (2017)
Yehuda Shemariah Kaplan
Authors: Ulla Trend, Leon Kaplan
Journal: BMJ (2020)

Yehuda Shemariah Kaplan was born and raised in Cape Town, South Africa. After graduating he spent his early career in South Africa, working in Cape Town, Johannesburg, Boksburg, and Germiston, covering a wide range of medical disciplines with a focus on general medicine and paediatrics.

Yehuda and his wife, Ruth, were active in the anti-apartheid movement, and in 1963 this forced their urgent departure …
Diseases of the Stomach. A text-book for practitioners and students.
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FRI0236 The effects of low-energy laser and exercise therapy in patients with chronic low back pain: a double-blind controlled trial
Authors: M Karakoç, A Gür, K Nas, R Çevik, AJ Saraç, F Erdoðan, M Karakoç (Çelik)
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> Low back pain is a ubiquitous health, problem and leads to majör problems. Low-energy laser biostimulation can be used to treat low back pain in last years. <h3>Objectives</h3> The aim of this double-blind controlled clinical study is to evaluate the effectiveness laser and combined exercise + laser in patients with chronic low back pain. <h3>Methods</h3> Forty patients with chronic low back pain randomly divided into two groups of 20 patients. 20 patients in the first group received low-energy laser + exercise treatment, other group received low-energy laser treatment alone. The parameters such as pain and muscle strength were assessed in all patients pretreatment and posttreatment. Pain measurement was done using the visual anologue scale. Muscle strength measurement (m. rectus abdominus, oblicus, hip abductors, hip adductors, extensors and internal rotators, knee flexors and extansors, foot flexors and extansors, and dorsal extansors) was done using the manual muscle strength testing. <h3>Results</h3> Both groups demonstrated significant improvements visual analogue scale and rectus abdominus, hip adductors and abductors in posttreatment (p &lt; 0.05), but no relative advantage was found for either group (p &gt; 0.05). <h3>Conclusion</h3> In conclusion, under the conditions of this study, low-energy laser stimulation plus exercise did not provide a significant advantage over exercise alone.
Injectable Hydrogels: Microskin‐Inspired Injectable MSC‐Laden Hydrogels for Scarless Wound Healing with Hair Follicles (Adv. Healthcare Mater. 10/2020)
Authors: Xin Zheng, Zhaozhao Ding, Weinan Cheng, Qiang Lu, Xiangdong Kong, Xiaozhong Zhou, Guozhong Lu, David L. Kaplan
Journal: Advanced Healthcare Materials (2020)

In article number 2000041 by Qiang Lu, Xiaozhong Zhou, Guozhong Lu, and co-workers, microgels composed of aligned silk nanofibers are used to load mesenchymal stem cells (MSCs) to actively modulate the paracrine. The MSCs-laden microgels are blended with injectable silk nanofiber hydrogels to accelerate the wound healing. The synergistic action of MSCs-laden hydrogel systems stimulates angiogenesis and M1-M2 phenotype switching of macrophages, achieving scarless skin regeneration with hair follicles.
Research at the Interface of Primary and Specialty Care
Authors: Clifton R. Gaus
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MxA suppresses TAK1-IKKα/β-NF-κB mediated inflammatory cytokine production to facilitate Mycobacterium tuberculosis infection
Authors: Xinying Zhou, Lijie Zhang, Linmiao Lie, Zelin Zhang, Bo Zhu, Jiahui Yang, Yuchi Gao, Pengfei Li, Yingqi Huang, Hui Xu, Yanfen Li, Xialin Du, Chaoying Zhou, Shengfeng Hu, Qian Wen, Xiao-Ping Zhong, Li Ma
Journal: Journal of Infection (2020)
Phase I Trial of Regulatory T-Cell Donor Lymphocyte Infusion Plus Daily Low-Dose Interleukin-2 for Steroid-Refractory Chronic Graft-Versus-Host Disease
Authors: Sarah Nikiforow, Haesook T Kim, Kyle T Jones, Jeremy Stewart, Heather Garrity, Heather Daley, Shanna Richard, Renee Manduke, Marie Chammas, Carol Reynolds, Andrew Burden, Jennifer Whangbo, Bruce Blazar, Philippe Armand, Vincent T Ho, Edwin Alyea, Corey Cutler, Joseph H. Antin, Robert J. Soiffer, Jerome Ritz, John Koreth
Journal: Blood (2017)
Do Reference Standards Hold Back the Progress of Medicine?
Authors: Paul Glasziou
Journal: Annals of Internal Medicine (2009)

Letters19 May 2009Do Reference Standards Hold Back the Progress of Medicine?Paul Glasziou, MB, BS, PhD, Les Irwig, MB, MCh, PhD, and Jonathan Deeks, PhDPaul Glasziou, MB, BS, PhDFrom University of Oxford, Oxford OX3 7LF, United Kingdom; University of Sydney, Sydney, New South Wales 2006, Australia; and University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.Search for more papers by this author, Les Irwig, MB, MCh, PhDFrom University of Oxford, Oxford OX3 7LF, United Kingdom; University of Sydney, Sydney, New South Wales 2006, Australia; and University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.Search for more papers by this author, and Jonathan Deeks, PhDFrom University of Oxford, Oxford OX3 7LF, United Kingdom; University of Sydney, Sydney, New South Wales 2006, Australia; and University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-10-200905190-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Although we agree with Drs. Smulders and Thijs that researchers and clinicians should pay more attention to the changes in spectrum that may occur with new tests, we think that the ideas of reference standards and diagnosis will remain useful. Some new tests do clearly alter the spectrum of illness, which is why we emphasized the need to consider the clinical consequences of such additional cases. Indeed, we have been particularly concerned about the detection of “inconsequential” disease (that is, test-detected diseases that will have no impact on the patient during his or her lifetime) (1).However, not ...Reference1. Irwig L, Houssami N, Armstrong B, Glasziou P. Evaluating new screening tests for breast cancer [Editorial]. BMJ. 2006;332:678-9. [PMID: 16565097] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Oxford, Oxford OX3 7LF, United Kingdom; University of Sydney, Sydney, New South Wales 2006, Australia; and University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoWhen Should a New Test Become the Current Reference Standard? Paul Glasziou , Les Irwig , and Jonathan J. Deeks Do Reference Standards Hold Back the Progress of Medicine? Yvo M. Smulders and Abel Thijs Metrics 19 May 2009Volume 150, Issue 10Page: 735-736KeywordsConflicts of interestDecision making ePublished: 19 May 2009 Issue Published: 19 May 2009 CopyrightCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Broken handle cord of impacted biliary basket – rescue by cholangioscopy with laser lithotripsy
Authors: Tomislav Bokun, Mario Tadic, Admir Kurtcehajic, Ivica Grgurevic, Milan Kujundzic
Journal: Endoscopy (2020)

Endoscopic retrograde cholangiopancreatography (ERCP) is the gold standard procedure for the treatment of bile duct stones, and most stones are successfully removed with accessories such as biliary baskets or extraction balloons. Impaction of a biliary basket is not an uncommon complication of this procedure, being reported in 0.8 % – 5.9 % of cases. Mechanical lithotripsy usually solves the problem by crushing the stone, followed by extraction of the stone fragments. However, on rare occasions, fracture of the basket occurs during mechanical lithotripsy, and this can pose a special management problem, depending on where the breakage occurs [1] [2] [3]. We report the successful management of an impacted biliary basket after breakage of the basket handle cord during extra-endoscopic mechanical lithotripsy.
BBB-penetrating codelivery liposomes treat brain metastasis of non-small cell lung cancer with EGFR<sup>T790M</sup> mutation
Authors: Weimin Yin, Yuge Zhao, Xuejia Kang, Pengfei Zhao, Xuhong Fu, Xiaopeng Mo, Yakun Wan, Yongzhuo Huang
Journal: Theranostics (2020)

EGFR TKI therapy has become a first-line regimen for non-small cell lung cancer (NSCLC) patients with EGRF mutations. However, there are two big challenges against effective therapy--the secondary EGFR mutation-associated TKI resistance and brain metastasis (BMs) of lung cancer. The BMs is a major cause of death for advanced NSCLC patients, and the treatment of BMs with TKI resistance remains difficult. Methods: Tumor-associated macrophages (TAM) is a promising drug target for inhibiting tumor growth, overcoming drug resistance, and anti-metastasis. TAM also plays an essential role in regulating tumor microenvironment. We developed a dual-targeting liposomal system with modification of anti-PD-L1 nanobody and transferrin receptor (TfR)-binding peptide T12 for codelivery of simvastatin/gefitinib to treat BMs of NSCLC. Results: The dual-targeting liposomes could efficiently penetrate the blood-brain barrier (BBB) and enter the BMs, acting on TAM repolarization and reversal of EGFRT790M-associated drug resistance. The treatment mechanisms were related to the elevating ROS and the suppression of the EGFR/Akt/Erk signaling pathway. Conclusion: The dual-targeting liposomal codelivery system offers a promising strategy for treating the advanced EGFRT790M NSCLC patients with BMs.
Modulating the Selectivity and Stealth Properties of Ellipsoidal Polymersomes through a Multivalent Peptide Ligand Display
Authors: Kristel C. Tjandra, Chelsea R. Forest, Chin Ken Wong, Sheilajen Alcantara, Hannah G. Kelly, Yi Ju, Martina H. Stenzel, Joshua A. McCarroll, Maria Kavallaris, Frank Caruso, Stephen J. Kent, Pall Thordarson
Journal: Advanced Healthcare Materials (2020)

Abstract There is a need for improved nanomaterials to simultaneously target cancer cells and avoid non‐specific clearance by phagocytes. An ellipsoidal polymersome system is developed with a unique tunable size and shape property. These particles are functionalized with in‐house phage‐display cell‐targeting peptide to target a medulloblastoma cell line in vitro. Particle association with medulloblastoma cells is modulated by tuning the peptide ligand density on the particles. These polymersomes has low levels of association with primary human blood phagocytes. The stealth properties of the polymersomes are further improved by including the peptide targeting moiety, an effect that is likely driven by the peptide protecting the particles from binding blood plasma proteins. Overall, this ellipsoidal polymersome system provides a promising platform to explore tumor cell targeting in vivo.
Differential Methotrexate Resistance in Childhood T- Versus Common/PreB-Acute Lymphoblastic Leukemia Can Be Measured by an In Situ Thymidylate Synthase Inhibition Assay, But Not by the MTT Assay
Authors: Marianne G. Rots, Rob Pieters, Gert-Jan L. Kaspers, Christina H. van Zantwijk, Paul Noordhuis, Rob Mauritz, Anjo J.P. Veerman, Gerrit Jansen, Godefridus J. Peters
Journal: Blood (1999)
Prognostic Significance of Immune Cell Populations Identified by Machine Learning in Colorectal Cancer Using Routine Hematoxylin and Eosin–Stained Sections
Authors: Juha P. Väyrynen, Mai Chan Lau, Koichiro Haruki, Sara A. Väyrynen, Andressa Dias Costa, Jennifer Borowsky, Melissa Zhao, Kenji Fujiyoshi, Kota Arima, Tyler S. Twombly, Junko Kishikawa, Simeng Gu, Saina Aminmozaffari, Shanshan Shi, Yoshifumi Baba, Naohiko Akimoto, Tomotaka Ugai, Annacarolina Da Silva, Mingyang Song, Kana Wu, Andrew T. Chan, Reiko Nishihara, Charles S. Fuchs, Jeffrey A. Meyerhardt, Marios Giannakis, Shuji Ogino, Jonathan A. Nowak
Journal: Clinical Cancer Research (2020)

Abstract Purpose: Although high T-cell density is a well-established favorable prognostic factor in colorectal cancer, the prognostic significance of tumor-associated plasma cells, neutrophils, and eosinophils is less well-defined. Experimental Design: We computationally processed digital images of hematoxylin and eosin (H&amp;E)–stained sections to identify lymphocytes, plasma cells, neutrophils, and eosinophils in tumor intraepithelial and stromal areas of 934 colorectal cancers in two prospective cohort studies. Multivariable Cox proportional hazards regression was used to compute mortality HR according to cell density quartiles. The spatial patterns of immune cell infiltration were studied using the GTumor:Immune cell function, which estimates the likelihood of any tumor cell in a sample having at least one neighboring immune cell of the specified type within a certain radius. Validation studies were performed on an independent cohort of 570 colorectal cancers. Results: Immune cell densities measured by the automated classifier demonstrated high correlation with densities both from manual counts and those obtained from an independently trained automated classifier (Spearman's ρ 0.71–0.96). High densities of stromal lymphocytes and eosinophils were associated with better cancer-specific survival [Ptrend &amp;lt; 0.001; multivariable HR (4th vs 1st quartile of eosinophils), 0.49; 95% confidence interval, 0.34–0.71]. High GTumor:Lymphocyte area under the curve (AUC0,20μm; Ptrend = 0.002) and high GTumor:Eosinophil AUC0,20μm (Ptrend &amp;lt; 0.001) also showed associations with better cancer-specific survival. High stromal eosinophil density was also associated with better cancer-specific survival in the validation cohort (Ptrend &amp;lt; 0.001). Conclusions: These findings highlight the potential for machine learning assessment of H&amp;E-stained sections to provide robust, quantitative tumor-immune biomarkers for precision medicine.
ANCA autoantigen gene expression highlights neutrophil heterogeneity where expression in normal-density neutrophils correlates with ANCA-induced activation
Authors: Britta E. Jones, Carolina A. Herrera, Christian Agosto-Burgos, Joshua Starmer, William A. Bass, Caroline J. Poulton, Lauren Blazek, Candace D. Henderson, Yichun Hu, Susan L. Hogan, Peiqi Hu, Hong Xiao, Eveline Y. Wu, Dhruti P. Chen, J. Charles Jennette, Meghan E. Free, Ronald J. Falk, Dominic J. Ciavatta
Journal: Kidney International (2020)
Abstract 14565: Hemolysis-mediated Lung Vascular Permeability Contributes to the Development of Pulmonary Hypertension
Authors: Olga Rafikova, Elissa R Williams, Matthew L McBride, Paul Langlais, Lawrence Mandarino, Evgeny Zemskov, Ankit A Desai, Ruslan Rafikov
Journal: Circulation (2017)

Introduction: There is a great disparity between the prevalence of Pulmonary Arterial Hypertension (PAH) in the general population (0.005%) and patients with hemolytic anemias: up to 32% in sickle ...
Depression and Suicidal Ideation Among HIV-Infected Adults Receiving Efavirenz Versus Nevirapine in Uganda
Authors: Jonathan L. Chang, Alexander C. Tsai, Nicholas Musinguzi, Jessica E. Haberer, Yap Boum, Conrad Muzoora, Mwebesa Bwana, Jeffrey N. Martin, Peter W. Hunt, David R. Bangsberg, Mark J. Siedner
Journal: Annals of Internal Medicine (2018)

Some studies have found an association between efavirenz use and neuropsychiatric adverse outcomes in patients with HIV infection, but data from sub-Saharan Africa, where the drug is still widely u...