tbuckley/cabot-search huggingface dataset:
REVIEW OF EOSINOPHILIC ESOPHAGITIS REFERENCE SCORE (EOERS) FOR THE PRIMARY DIAGNOSTIC OF EOSINOPHILIC ESOPHAGITIS IN CHILDREN
Authors: Y Kaminskaya, K Marakhouski, O Pataleta, K Sanfirov
Journal: Endoscopy (2020)

Aims Since 2017 EoERS has been used for detection of eosinophilic esophagitis(EoE) in children. All of them manifestate of dysphagia and disturbances of esophageal transit.
ENDOSCOPIC GRADING OF GASTRIC INTESTINAL METAPLASIA PREDICTS EARLY GASTRIC NEOPLASIA: CAN WE REPLACE HISTOLOGY ASSESSMENT ALSO IN THE WEST?
Authors: P Marcos, G Brito-Gonçalves, D Libânio, I Pita, R Castro, I Sá, M Dinis-Ribeiro, P Pimentel-Nunes
Journal: Endoscopy (2020)

Aims To assess the predictive value of endoscopic grading of gastric intestinal metaplasia (EGGIM), operative link on gastritis assessment (OLGA) and operative link on gastric intestinal metaplasia (OLGIM) for early gastric neoplasia (EGN) and investigate other factors possibly associated with its development.
ENDOSCOPIC RESECTION OF LOW GRADE DYSPLASIA IN BARRETT’S OESOPHAGUS: A RETROSPECTIVE STUDY ABOUT 61 PATIENTS
Authors: Fabrice Caillol, Arthur Falque, Margherita Pizzicannella, Christian Pesenti, Jean Philippe Ratone, Solene Hoibian, Yanis Dahel, Jerome Guiramand, Flora Poizat, Marc Giovannini
Journal: Endoscopy (2020)

Aims Barrett Oesohagus (BO) is a pre-cancerous lesion. ESGE recommends LGD endoscopic treatment. Because of the low rate of stenosis with thermablation, ESGE recommends radiofrequency for LGD in BO. However, pre-operative biopsy for BO are nor reliable. That´s why the policy of our unit is to perform endoscopic resection (ER) of LGD, allowing definitive histology on resection piece. We evaluated in this study this management, comparing pre-operative biopsy and final resection, and evaluating complication rate of ER.
Continuous Dexamethasone Infusion for Seven Hours in Patients with the Cushing Syndrome
Authors: Pieter Biemond, Frank H. de Jong, Steven W. J. Lamberts
Journal: Annals of Internal Medicine (2020)

Abstract Study Objective:To determine the usefulness of the continuous intravenous dexamethasone suppression test in the differential diagnosis of patients with the Cushing syndrome. Design:Compari...
THE GASTROPACK SYSTEM AS A MODEL FOR EGD APPROPRIATENESS IN PATIENTS WITH UPPER GASTROINTESTINAL SYMPTOMS: A COMPARISON WITH THE OPEN ACCESS SYSTEM
Authors: L Ceroni, F Lodato, C Fabbri, P Tubertini, M Biselli, A Gramenzi, MT Migliano, F Ferrara, F Buonfiglioli, R Schiumerini, A Polifemo, A Alberani, A Gazzola, V Cennamo
Journal: Endoscopy (2020)

Aims EGD appropriate use in Open-Access System (OAS) is a relevant issue in Endoscopy due to the significant amount of economic resources and time involved. In Italy, previous data reported a 22.9% rate of inappropriate EGDs according to ASGE guidelines. Inappropriate prescriptions were made more frequently by General Practitioners (GPs)s (29.4%) compared to specialists (12.9%). This study aims to evaluate if the GASTROPACK SYSTEM (GS), a new method to access gastroenterological care, may reduce inappropriate indications to EGD compared to the OAS.
Transactions of Medical Societies.
Authors: Gino Galeotti
Journal: JAMA (1889)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Suppression of Endothelial AGO1 Promotes Adipose Tissue Browning and Improves Metabolic Dysfunction
Authors: Xiaofang Tang, Yifei Miao, Yingjun Luo, Kiran Sriram, Zhijie Qi, Feng-Mao Lin, Yusu Gu, Chih-Hung Lai, Chien-Yi Hsu, Kirk L. Peterson, Kendall Van Keuren-Jensen, Patrick T. Fueger, Gene W. Yeo, Rama Natarajan, Sheng Zhong, Zhen Bouman Chen
Journal: Circulation (2020)

Metabolic disorders such as obesity and diabetes mellitus can cause dysfunction of endothelial cells (ECs) and vascular rarefaction in adipose tissues. However, the modulatory role of ECs in adipose tissue function is not fully understood. Other than vascular endothelial growth factor-vascular endothelial growth factor receptor-mediated angiogenic signaling, little is known about the EC-derived signals in adipose tissue regulation. We previously identified Argonaute 1 (AGO1; a key component of microRNA-induced silencing complex) as a crucial regulator in hypoxia-induced angiogenesis. In this study, we intend to determine the AGO1-mediated EC transcriptome, the functional importance of AGO1-regulated endothelial function in vivo, and the relevance to adipose tissue function and obesity.We generated and subjected mice with EC-AGO1 deletion (EC-AGO1-knockout [KO]) and their wild-type littermates to a fast food-mimicking, high-fat high-sucrose diet and profiled the metabolic phenotypes. We used crosslinking immunoprecipitation- and RNA-sequencing to identify the AGO1-mediated mechanisms underlying the observed metabolic phenotype of EC-AGO1-KO. We further leveraged cell cultures and mouse models to validate the functional importance of the identified molecular pathway, for which the translational relevance was explored using human endothelium isolated from healthy donors and donors with obesity/type 2 diabetes mellitus.We identified an antiobesity phenotype of EC-AGO1-KO, evident by lower body weight and body fat, improved insulin sensitivity, and enhanced energy expenditure. At the organ level, we observed the most significant phenotype in the subcutaneous and brown adipose tissues of KO mice, with greater vascularity and enhanced browning and thermogenesis. Mechanistically, EC-AGO1 suppression results in inhibition of thrombospondin-1 (THBS1/TSP1), an antiangiogenic and proinflammatory cytokine that promotes insulin resistance. In EC-AGO1-KO mice, overexpression of TSP1 substantially attenuated the beneficial phenotype. In human endothelium isolated from donors with obesity or type 2 diabetes mellitus, AGO1 and THBS1 are expressed at higher levels than the healthy controls, supporting a pathological role of this pathway.Our study suggests a novel mechanism by which ECs, through the AGO1-TSP1 pathway, control vascularization and function of adipose tissues, insulin sensitivity, and whole-body metabolic state.
A RETROSPECTIVE STUDY TO EVALUATE OPTIMAL PROCEDURE TIME TO PREVENT POST-ERCP PANCREATITIS USING DECISION TREE ANALYSIS
Authors: CM Cho, MK Jung, J Heo, GC Kim, AN Seo
Journal: Endoscopy (2020)

Aims Pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP) is a major concern among procedure-related adverse events. Although several risk factors were identified from previous studies, there was no study for optimal procedure time to prevent post-ERCP pancreatitis (PEP). We reviewed ERCP database to evaluate the association between procedure time and PEP.
In adults with AF who regularly drink alcohol, a 6-month abstinence intervention reduced AF recurrence and burden
Authors: Meghana Gore, Vijaiganesh Nagarajan
Journal: Annals of Internal Medicine (2020)

ACP Journal Club19 May 2020In adults with AF who regularly drink alcohol, a 6-month abstinence intervention reduced AF recurrence and burdenMeghana Gore, MD, Vijaiganesh Nagarajan, MD, MRCP, FACP, FACC, FSCAIMeghana Gore, MDMemorial Hermann Hospital, Katy, Texas, USA (M.G.)Search for more papers by this author, Vijaiganesh Nagarajan, MD, MRCP, FACP, FACC, FSCAIUniversity of Texas, Houston, Texas, USA (V.N.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJ202005190-053 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationVoskoboinik A, Kalman JM, De Silva A, et al. Alcohol abstinence in drinkers with atrial fibrillation. N Engl J Med. 2020;382:20-8. https://pubmed.ncbi.nlm.nih.gov/31893513Clinical Impact RatingsGIM/FP/GP: Cardiology: References1 Chugh SS, Havmoeller R, Narayanan K, et al. Worldwide epidemiology of atrial fibrillation: a Global Burden of Disease 2010 Study. Circulation. 2014;129:837-47. [PMID: 24345399] Google Scholar2 Kodama S, Saito K, Tanaka S, et al. Alcohol consumption and risk of atrial fibrillation: a meta-analysis. J Am Coll Cardiol. 2011;57:427-36. [PMID: 21251583] Google Scholar Author, Article, and Disclosure InformationAffiliations: Memorial Hermann Hospital, Katy, Texas, USA (M.G.)University of Texas, Houston, Texas, USA (V.N.)Disclosures: The commentators have disclosed no conflicts of interest. The forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M19-3042.This article was published at Annals.org on -13 May 2020. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 19 May 2020Volume 172, Issue 10Page: JC53KeywordsAlcohol consumptionAlcoholsAtrial fibrillationHeart rateIntent to treat analysisMedical risk factorsNumber needed to treatPacemakersTachycardiaUrine ePublished: 1 May 2020 Issue Published: 19 May 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract 3829: DNA methylation profile in papillary thyroid cancer according to BRAF (V600E) mutation
Authors: Caroline Moraes Beltrami, Mariana Bisarro dos Reis, Mateus Camargo Barros-Filho, Fabio Albuquerque Marchi, Hellen Kuasne, Srikant Ambatipudi, Zdenko Herceg, Luiz Paulo Kowalski, Silvia Regina Rogatto
Journal: Cancer Research (2015)

Abstract Background: Thyroid cancer is an important health burden and the endocrine neoplasia with highest incidence in worldwide. Papillary thyroid cancer (PTC), the most common thyroid malignancy, is frequently associated with BRAF V600E mutation. This mutation occurs in around 45% of PTC cases and it has been associated with aberrant gene methylation. This finding suggests an association between genetic and epigenetic alterations in tumor development. The goal of this study was to evaluate the methylation profile in PTC samples according to BRAF mutation. Patients and Method: Forty-two PTC were included in this study (28 positive for BRAF V600E mutation). Normal and tumoral samples were obtained from patients submitted to total thyroidectomy and radioiodine therapy. The pyrosequencing method was used to detect and quantify the BRAF V600E mutation in tumor samples. The methylation analysis was performed by microarray platform Methylation 450 Human Infinium®BeadChip (Illumina), according to the manufacturer's recommendations. The data were normalized and analyzed using SVA, wateRmelon and LIMMA package. It was considered only probes with Delta-Beta (β) = 0.1 and p value ≤ 0.001. Integrative analyses were performed using expression data generated from previous analysis. The findings were compared with 56 samples from The Cancer Genome Atlas (TCGA). Genes enrichment to biological pathways were performed using Ingenuity Pathway Analysis software. Results: It was identified 404 differentially methylated probes (291 hypomethylated and 113 hypermethylated) of which 195 were validated by TCGA. After the integrative analysis with expression data, nine TOP genes (INF2, TACSTD2, RAB15, TM7SF4, GJB3, CDSN, BHLHE41, GTF2IRD1, CXXC5) were selected with hypomethylation and overexpression. Three of them, BHLHE41, CDSN and INF2, were enriched to cancer and endocrine system disorders pathways (P = 4,47×10−2), highlighting the relevance of these genes in PTC Conclusion: This study point out putative drivers in PTC according to BRAF mutation revealing epigenetic mechanisms that contributes with cell proliferation and aggressiveness in thyroid carcinoma. Citation Format: Caroline Moraes Beltrami, Mariana Bisarro dos Reis, Mateus Camargo Barros-Filho, Fabio Albuquerque Marchi, Hellen Kuasne, Srikant Ambatipudi, Zdenko Herceg, Luiz Paulo Kowalski, Silvia Regina Rogatto. DNA methylation profile in papillary thyroid cancer according to BRAF (V600E) mutation. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3829. doi:10.1158/1538-7445.AM2015-3829
USEFULNESS OF NARROW-BAND IMAGING WITH NEAR-FOCUS MAGNIFICATION FOR DISCRIMINATING THE GASTRIC TUMOR MARGIN BEFORE ENDOSCOPIC RESECTION: A PROSPECTIVE RANDOMIZED MULTICENTER TRIAL
Authors: JY Jang, JW Kim, Y Jung, GH Kim, BW Bang, JC Park, HS Choi, JH Cho, YW Chang
Journal: Endoscopy (2020)

Aims This prospective randomized multicenter study investigated the usefulness of near focus with narrow-band imaging (NF-NBI) for determining gastric tumor margins compared with indigo carmine chromoendoscopy (ICC) before endoscopic submucosal dissection (ESD).
LOW GRADE GASTRIC MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA: CLINICOPATHOLOGICAL FACTORS ASSOCIATED WITH HELICOBACTER PYLORI ERADICATION AND TUMOR REGRESSION
Authors: DH Lee, HI Shim, CM Shin, H Yoon, YS Park, N Kim
Journal: Endoscopy (2020)

Aims Eradication of Helicobacter pylori is widely accepted as the initial therapy for low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma. The aim of this study was to assess the remission and relapse rates of low-grade gastric MALT lymphoma after H. pylori eradication and to identify the clinical factors affecting remission.
Is the Prone Position Helpful During Spontaneous Breathing in Patients With COVID-19?
Authors: Irene Telias, Bhushan H. Katira, Laurent Brochard
Journal: JAMA (2020)

Chiara Sartini, MD; Moreno Tresoldi, MD; Paolo Scarpellini, MD; Andrea Tettamanti, DPT; Francesco Carcò, MD; Giovanni Landoni, MD; Alberto Zangrillo, MD
The Role of the Intestine in the Pathogenesis of Primary Sclerosing Cholangitis: Evidence and Therapeutic Implications
Authors: Gregory Dean, Stephen Hanauer, Josh Levitsky
Journal: Hepatology (2020)

The pathogenesis of primary sclerosing cholangitis (PSC), a progressive biliary tract disease without approved medical therapy, is not well understood. The relationship between PSC and inflammatory bowel disease has inspired theories that intestinal factors may contribute to the development and progression of hepatobiliary fibrosis in PSC. There is evidence from both fecal and mucosa‐associated microbial studies that patients with PSC harbor an abnormal enteric microbiome. These organisms are thought to produce toxic byproducts that stimulate immune‐mediated damage of hepatocytes and the biliary tree. The link between these mechanisms may be related to altered intestinal permeability leading to migration of bacteria or associated toxins to the liver through the portal circulation. In support of these concepts, early trials have demonstrated improved biochemical parameters and symptoms of PSC with oral antibiotics, ostensibly through manipulation of the enteric microbiota. This article reviews the published literature for evidence as well as gaps in knowledge regarding these mechanisms by which intestinal aberrations might drive the development of PSC. We also identify areas of future research that are needed to link and verify these pathways to enhance diagnostic and therapeutic approaches.
Arthroscopic surgery for knee pain
Authors: Teppo L N Järvinen, Gordon H Guyatt
Journal: British Journal of Sports Medicine (2017)

A highly questionable practice without supporting evidence of even moderate quality

With 150 000 knee arthroscopies carried out in the United Kingdom each year, and about five times that number in the United States,1 2 arthroscopic partial meniscectomy—keyhole surgery for middle aged to older adults with knee pain to trim a torn meniscus—is one of the most common surgical procedures. Considering the enormous volume, it is natural to think that there is compelling evidence for the procedure being beneficial. Remarkably, this is not so.

It is barely a decade since the publication of the first controlled trial addressing knee arthroscopy using placebo surgery as a comparator.3 Since then a series of rigorous trials, summarised in two recent systematic reviews and meta-analyses, provide compelling evidence that arthroscopic knee surgery offers little benefit for most patients with knee pain.4 5 The latest …
A rapidly deployable individualized system for augmenting ventilator capacity
Authors: Shriya S. Srinivasan, Khalil B. Ramadi, Francesco Vicario, Declan Gwynne, Alison Hayward, David Lagier, Robert Langer, Joseph J. Frassica, Rebecca M. Baron, Giovanni Traverso
Journal: Science Translational Medicine (2020)

A system of valves and sensors provides individualized respiratory support for two individuals from one ventilator, with acute testing in pigs.
ENDOSCOPIC RESECTION OF UPPER GASTROINTESTINAL SUBMUCOSAL TUMOURS: ESD, STER AND ETFR
Authors: H Awadie, S Gupta, IB Yishay, J Yang, NG Burgess, EYT Lee, V Kwan, MJ Bourke
Journal: Endoscopy (2020)

Aims Upper gastrointestinal submucosal tumours (U-SMTs) are infrequent but may contain malignant potential. Some may require removal for treatment and on occasion definitive diagnosis may necessitate complete excision. A range of techniques have been developed to facilitate endoscopic removal and avoid surgical resection, even for lesions involving the muscularis propria (MP). This includes endoscopic submucosal dissection (ESD), submucosal-tunnelling endoscopic resection (STER) and endoscopic full-thickness resection (EFTR).
Should Tests for Chlamydia trachomatis Cervical Infection Be Done During Routine Gynecologic Visits
Authors: Russell S. Phillips, Mark D. Aronson, William C. Taylor, Charles Safran
Journal: Annals of Internal Medicine (2020)

Abstract We used decision analysis to estimate the clinical and economic implications of testing for cervical infection caused byChlamydia trachomatisin women during routine gynecologic visits. We ...
ARTIFICIAL INTELLIGENCE, TRAINED WITH A ROUGH BINARY CLASSIFICATION, CAN SELECT SIGNIFICANT IMAGES OF CAPSULE ENDOSCOPY
Authors: J Park, Y Hwang, YJ Lim, JH Nam, DJ Oh, KB Kim, HJ Song, SH Kim, MK Jung
Journal: Endoscopy (2020)

Aims Since the introduction of computer vision technology using Deep-learning, various acceptable results have been reported for the recognition of small bowel pathologies in capsule endoscopy. However, the results are limitedly dealt with lesions such as erosions, ulcers, and angioectasia, which are easy to apply machine learning technologies. We classified capsule endoscopy images into those with and without significant lesions, and studied whether artificial intelligence, which learned the images of binary classification, can correctly suggest images containing significant lesions.
Abstract 14893: Structural Variant of the Designer Peptide MANP: Differential Actions With cGMP Activation in Cardiorenal Functions
Authors: Shinobu Sugihara, Tomoko Ichiki, Yang Chen, Gail J Harty, Denise M Heublein, Seethalakshimi R Iyer, Brenda K Huntley, S J Sangaralingham, Daniel J McCormick, Alessia Buglioni, John C Burnett
Journal: Circulation (2017)

Introduction: M-atrial natriuretic peptide (MANP) is a novel Mayo Clinic engineered guanylyl cyclase A (GC-A) receptor and 3’,5’-cyclic guanosine monophosphate (cGMP) activating peptide based on th...
PREVALENCE AND RISK FACTORS FOR PRENEOPLASTIC AND NEOPLASTIC LESIONS OF THE COLON AND RECTUM IN PATIENTS UNDER 50 REFERRED FOR COLONOSCOPY
Authors: S Agazzi, MV Lenti, C Klersy, E Strada, L Pozzi, L Rovedatti, S Costa, M Costetti, M Bardone, A Mauro, F De Grazia, A Di Sabatino
Journal: Endoscopy (2020)

Aims The American Cancer Society reduced the age of CRC screening from 50 to 45 years in 2018 in response to a recent increase in early onset-CRC1. Our primary aim was to analyse the prevalence of colorectal preneoplastic and neoplastic lesions in patients under 50 referred for colonoscopy in our center. The secondary aim was to identify possible risk factors for the development of these lesions.
Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90
Authors: Kamalika Moulick, Huazhong He, Danuta Zatorska, Joungnam Kim, Julia Aguirre, Nian Wu, Yuhong She, Robert Immormino, Daniel Gewirth, Gabriela Chiosis
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4733 

Hsp90 is a chaperone protein that allows cancer cells to tolerate the many components of dysregulated pathways. Its inactivation may result in targeting multiple molecular alterations and thus, in reverting the transformed phenotype. The PU-class, a purine-scaffold Hsp90 inhibitor series designed by our laboratory has been reported to be potent and selective against Hsp90 both in vitro and in vivo models of cancer. Here, a series of this class was synthesized and evaluated as inhibitors of the chaperone. The structure-activity relationship and selectivity for tumor Hsp90 of compounds within the series is presented. The study identifies water soluble derivatives (> 5 mM in PBS pH 7.4) of nanomolar potency (IC50 ∼ 50 nM) in cellular and animal models of cancer. Binding affinities of these compounds for Hsp90 correlate well with their biological activities. When administered in vivo to mice bearing MDA-MB-468 human breast cancer xenografted tumors, these agents result in pharmacologically relevant concentrations and accordingly, in modulation of Hsp90-client proteins in tumors.
Immunogenicity and Tolerability of Recombinant Serogroup B Meningococcal Vaccine Administered With or Without Routine Infant Vaccinations According to Different Immunization Schedules
Authors: N Gossger, Snape, Yu L-M., A Finn, G Bona, S Esposito, N Principi, J Diez-Domingo, E Sokal, B Becker, D Kieninger, R Prymula, P Dull, E Ypma, D Toneatto, A Kimura, A J Pollard
Journal: JAMA (2012)
Removing the handle of the Broad Street pump: measures to slow the spread of covid-19 in primary care teams
Authors: Simon de Lusignan, Tamsin Carlyon, Ajit Lalvani
Journal: BMJ (2020)

John Snow removed the handle of the Broad Street pump to halt a cholera epidemic. His approach was not to find the organism but to block transmission.1 One way to contain covid-19 is to assess patients remotely,2 but what about transmission within primary care teams? Research reporting the effectiveness of strict infection control measures34 and about the aerosol and surface stability of SARS-CoV-2 provide5 the basis for measures to reduce transmission in general practices. 

We have …
ANALYSIS OF POST-ERCP PANCREATITIS RATES IN THE HUNGARIAN ERCP REGISTRY
Authors: D Pécsi, L Szakó, I Altorjay, L Czakó, S Gódi, T Gyökeres, Z Szepes, Á Vincze
Journal: Endoscopy (2020)

Aims Endoscopic retrograde cholangiopancreatography (ERCP) is one of the most frequently applied advanced endoscopic technique for therapeutic purposes. However, it comes with a significant risk of adverse events. We aimed to analyse the post-ERCP pancreatitis rates in the Hungarian ERCP registry.