SAT0394 POSSIBLE POTENTIAL INTERACTIONS BETWEEN OBESITY, QUALITY OF LIFE, PSYCHOLOGICAL STATUS AND CLINICAL PARAMETERS IN PSORIATIC ARTHRITIS
Authors: Kevser Gok, Kemal Nas, Erkan Kilic, Betul Sargin, Sevtap Acer Kasman, Hakan Alkan, Nilay Sahin, Gizem Cengiz, Nihan Cuzdan, Ilknur Albayrak Gezer, Dilek Keskin, Cevriye Mülkoğlu, Hatice Resorku, İsmihan Sunar, Ajda Bal Hasturk, Mehmet Tuncay Duruöz, Okan Kucukakkas, Ozan Volkan Yurdakul, Meltem Alkan Melikoglu, Yildiray Aydin, Figen Ayhan, Hatice Bodur, Mustafa Calis, Erhan Capkin, Gul Devrimsel, Sami Hizmetli, Ayhan Kamanli, Yasar Keskin, Hilal Kocabas, Oznur Kutluk, Nesrin Şen, Omer Faruk Sendur, Ibrahim Tekeoğlu, Murat Toprak, Sena Tolu, Tiraje Tuncer
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background:</h3> Psoriatic arthritis (PsA), a chronic rheumatic disease associated with reduced quality of life. Obesity is an important clinical problem which may interfere with loss of functioning and quality of life. Obesity is usually an overlooked entity in patients with PsA. Several studies were invastigated prevalence and the impact of obesity on disease activity in patients with PsA, however relationship between psychological status and quality of life have not been evaluated comparatively. <h3>Objectives:</h3> To assess the impact of obesity on quality of life, psychological status and clinical parameters in patients with PsA. <h3>Methods:</h3> Patients with PsA were recruited who met CASPAR classification criteria enrolled by Turkish League Against Rheumatism-NETWORK (TLAR-NETWORK) derived from 24 different centers of our country.Patients with BMI ≥30 kg/m<sup>2</sup> were considered obese. Differences among patients with or without obesity were assessed.VAS fatigue, psychological status and health related quality of life measures [SF-36; HAQ; Psoriatic arthritis quality of life (PsAQoL); Hospital Anxiety and Depresson Scale], FACIT-Fatigue, DAS28, BASDAI, BASFI, BASMI, Maastrich Ankylosing Spondylitis Enthesitis <i>Score</i> (MASES) and Psoriasis area severity index (PASI) scores were compered between this groups. <h3>Results:</h3> A total 1130 patients with PsA (36.0% male, 64.0% female) included in this study. In this cohort 37.6% obese and 62.4% non-obese. The presence of peripheral arthritis, enthesitis, dactylitis, uveitis and spine involvement, PASI scores as well as MASES scores were quite similar between patients with and without obesity. Obese patients had significantly higher scores in VAS fatigue and disease activity, poorer QoL and physical functions compared to non-obese patients (p&lt;0.05). Obese patients had high risk for anxiety and depression (p &lt;0.05). <h3>Conclusion:</h3> Obesity associated with the risk of depression and anxiety, fatigue, poorer QoL and higher disease activity.These findings suggest that obesity should be considered while assessing patients with PsA. <h3>References</h3> [1] Li W,Han J,Qureshi AA.Obesity and risk of incident psoriatic arthritis in US women.Ann Rheum Dis.2012Aug;71(8):1267-72. [2] Klingberg E,Bilberg A,Björkman S, et al.Weight loss improves disease activity in patients with psoriatic arthritis and obesity:an interventional study.Arthritis Res Ther.2019Jan11;21(1):17 <h3>Disclosure of Interests:</h3> Kevser Gok: None declared, Kemal Nas: None declared, Erkan Kilic: None declared, Betul Sargin: None declared, Sevtap Acer Kasman: None declared, Hakan Alkan: None declared, Nilay Sahin: None declared, Gizem Cengiz: None declared, Nihan Cuzdan: None declared, Ilknur Albayrak Gezer: None declared, Dilek Keskin: None declared, Cevriye Mülkoğlu: None declared, Hatice Resorku: None declared, İsmihan Sunar: None declared, Ajda Bal Hasturk: None declared, Mehmet Tuncay Duruöz Grant/research support from: Abvie, Speakers bureau: Novartis, AMGEN, Abdi İbrahim, İlko, Okan Kucukakkas: None declared, Ozan Volkan Yurdakul: None declared, Meltem Alkan Melikoglu: None declared, Yildiray Aydin: None declared, Figen Ayhan: None declared, Hatice Bodur: None declared, Mustafa Calis: None declared, Erhan Capkin: None declared, Gul Devrimsel: None declared, SAMI HIZMETLI: None declared, Ayhan Kamanli: None declared, Yasar Keskin: None declared, Hilal Kocabas: None declared, Oznur Kutluk: None declared, Nesrin Şen: None declared, Omer Faruk Sendur: None declared, ibrahim tekeoğlu: None declared, Murat Toprak: None declared, Sena Tolu: None declared, Tiraje Tuncer: None declared