tbuckley/cabot-search huggingface dataset:
Letter on ‘Pharmacy‐based interdisciplinary intervention for patients with chronic heart failure: results of the PHARM‐CHF randomized controlled trial’: reply
Authors: Martin Schulz, Nina Griese‐Mammen, Michael Böhm, Ulrich Laufs
Journal: European Journal of Heart Failure (2019)

We thank Dr. Kalmanovich and colleagues for their comments on our randomized controlled trial on improving medication adherence and quality of life of heart failure (HF) patients by a pharmacist-led interdisciplinary approach.1 This study showed that pharmacy care safely improved adherence to HF medications and quality of life. These data extend recent consensus statements of both the Canadian Cardiovascular Society guidelines for the management of HF2 and the German clinical practice guideline on chronic HF3 that acknowledge the available evidence of pharmacist care and interdisciplinary care.4, 5 Topics and tasks include prevention of HF, particularly by improving adherence to antihypertensives, providing medication reviews, assuring appropriate self-medication, and improving both medication safety and adherence.4 We congratulate Kalmanovich et al. to their research plan. Their study will hopefully provide additional randomized evidence for the effects of interdisciplinary care in patients with HF.
Type I interferon suppresses memory Th2 cell cytokine secretion from allergic subjects
Authors: Fenghong Chen, Regina K. Rowe, Michelle A. Gill, J. David Farrar
Journal: Allergy (2019)

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
CA1-projecting subiculum neurons facilitate object–place learning
Authors: Yanjun Sun, Suoqin Jin, Xiaoxiao Lin, Lujia Chen, Xin Qiao, Li Jiang, Pengcheng Zhou, Kevin G. Johnston, Peyman Golshani, Qing Nie, Todd C. Holmes, Douglas A. Nitz, Xiangmin Xu
Journal: Nature Neuroscience (2019)
Potential biomarkers for pseudoprogression in malignant glioma.
Authors: Hiroyuki Momota, Masazumi Fujii, Kazuya Motomura, Atsushi Natsume, Toshihiko Wakabayashi
Journal: Journal of Clinical Oncology (2013)

e13012 Background: Pseudoprogression (psPD) is defined as an increase of enhancing lesions on MRI without a real advancement of the disease, and it occurs in up to 20% of glioma patients who have been treated with temozolomide chemoradiotherapy. However, there are no reliable methods to distinguish psPD from true progression. Methods: To elucidate the utility of immunophenotypic markers in predicting psPD, we retrospectively investigated 21 consecutive patients with malignant glioma operated between August 2007 and December 2010 and treated with temozolomide therapy. Immunostaining for CD44, CD68, EGFR, and p53 was used to determine the immunophenotypic profile of these gliomas. Immunohistochemical scoring was made as follows: weak CD44 staining (1 point), weak CD68 staining (1 point), no strong EGFR staining (1 point), and strong p53 staining (1 point). Results: Fourteen glioblastomas (GBMs), 2 glioblastomas with oligodendroglioma component (GBMOs), and 5 anaplastic oligodendrogliomas (AOs) were included in this study. psPD occurred in 6 patients (3 GBMs, 1 GBMO, and 2AOs). In our scoring system, 2 tumors obtained 4 points and these tumors showed psPD (100%), 5 tumors obtained 3 points and 2 psPDs occured (40%), 5 tumors obtained 2 points and 2 psPDs occured (40%), and 9 tumors obtained 1 or 0 point and no tumors had psPD (0%). Median overall survial time was 36.3 mo in patients with psPD and 18.1 mo in patients without psPD, but there was no significant difference between the groups. Conclusions: Our study demonstrates that psPD can be predicted by simple immunohistochemical scoring method. In this scoring system, the sensitivity for psPD is 100% in patients with high score (4 points), 40% in patients with medium score (2–3 points), and 0% in patients with low score (0–1 point). Careful follow-up is needed after chemoradiation therapy in glioma patients with high to medium score.
Improving grain yield, stress resilience and quality of bread wheat using large-scale genomics
Authors: Philomin Juliana, Jesse Poland, Julio Huerta-Espino, Sandesh Shrestha, José Crossa, Leonardo Crespo-Herrera, Fernando Henrique Toledo, Velu Govindan, Suchismita Mondal, Uttam Kumar, Sridhar Bhavani, Pawan K. Singh, Mandeep S. Randhawa, Xinyao He, Carlos Guzman, Susanne Dreisigacker, Matthew N. Rouse, Yue Jin, Paulino Pérez-Rodríguez, Osval A. Montesinos-López, Daljit Singh, Mohammad Mokhlesur Rahman, Felix Marza, Ravi Prakash Singh
Journal: Nature Genetics (2019)
Concomitant medications and clinical outcomes in idiopathic pulmonary fibrosis
Authors: Michael Kreuter, David J. Lederer, Vincent Cottin, Nicolas Kahn, Brett Ley, Carlo Vancheri, Derek Weycker, Mark Atwood, Klaus-Uwe Kirchgaessler, Christopher J. Ryerson
Journal: European Respiratory Journal (2019)

<b>This <i>post hoc</i> exploratory analysis found no clear associations between frequently used concomitant medication combinations and disease progression in 1450 patients with IPF enrolled in phase III trials, but several combinations may require further study.</b>http://bit.ly/2ZzyMXR
Substantial Differences Between Cohorts of Patients Hospitalized With Heart Failure in Canada and the United States—Reply
Authors: Finlay A. McAlister, Erik Youngson
Journal: JAMA Cardiology (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Treatment Escalation and Rise in HbA[subscript 1c] Following Successful Initial Metformin Therapy
Authors: Gregory A. Nichols, Charles M. Alexander, Cynthia J. Girman, Sachin J. Kamal-Bahl, Jonathan B. Brown
Journal: Diabetes Care (2006)

OBJECTIVE:--To describe secondary failure of initial metformin therapy in patients who achieved initial HbA[subscript 1c] (A1C)  8.0% after at least 6 months on metformin. RESULTS:--The best A1C achieved within 1 year of metformin initiation was the most powerful predictor of avoiding secondary failure. Approximately 50% of subjects whose best A1C was 7-7.9% added/switched antihyperglycemic drugs within 36 months, whereas it took >60 months for those in the 6-6.9% A1C category to reach a 50% failure rate. Those who achieved an A1C  8% within 24 months. Only [approximately]25% of subjects in the 6-6.9% category failed by 48 months, and >80% of subjects in the <6% category remained below 8% through 60 months. CONCLUSIONS:--Whether defined by adding/switching to another drug or by reaching an A1C of 8%, secondary failure is inversely associated with the reduction of A1C achieved within the 1st year of metformin monotherapy.
Precipitation and Salmonellosis Incidence in Georgia, USA: Interactions between Extreme Rainfall Events and Antecedent Rainfall Conditions
Authors: Debbie Lee, Howard H. Chang, Stefanie Ebelt Sarnat, Karen Levy
Journal: Environmental Health Perspectives (2019)

The southeastern United States consistently has high salmonellosis incidence, but disease drivers remain unknown. Salmonella is regularly detected in this region's natural environment, leading to numerous exposure opportunities. Rainfall patterns may impact the survival/transport of environmental Salmonella in ways that can affect disease transmission.This study investigated associations between short-term precipitation (extreme rainfall events) and longer-term precipitation (rainfall conditions antecedent to these extreme events) on salmonellosis counts in the state of Georgia in the United States.For the period 1997-2016, negative binomial models estimated associations between weekly county-level extreme rainfall events (≥90th percentile of daily rainfall) and antecedent conditions (8-week precipitation sums, categorized into tertiles) and weekly county-level salmonellosis counts.In Georgia's Coastal Plain counties, extreme and antecedent rainfall were associated with significant differences in salmonellosis counts. In these counties, extreme rainfall was associated with a 5% increase in salmonellosis risk (95% CI: 1%, 10%) compared with weeks with no extreme rainfall. Antecedent dry periods were associated with a 9% risk decrease (95% CI: 5%, 12%), whereas wet periods were associated with a 5% increase (95% CI: 1%, 9%), compared with periods of moderate rainfall. In models considering the interaction between extreme and antecedent rainfall conditions, wet periods were associated with a 13% risk increase (95% CI: 6%, 19%), whereas wet periods followed by extreme events were associated with an 11% increase (95% CI: 5%, 18%). Associations were substantially magnified when analyses were restricted to cases attributed to serovars commonly isolated from wildlife/environment (e.g., Javiana). For example, wet periods followed by extreme rainfall were associated with a 34% risk increase (95% CI: 20%, 49%) in environmental serovar infection.Given the associations of short-term extreme rainfall events and longer-term rainfall conditions on salmonellosis incidence, our findings suggest that avoiding contact with environmental reservoirs of Salmonella following heavy rainfall events, especially during the rainy season, may reduce the risk of salmonellosis. https://doi.org/10.1289/EHP4621.
Abstract 11444: Generation of Induced Pluripotent Stem Cell-Derived Cardiomyocytes From Peripheral Blood Mononuclear Cells of Patients With Atrial Fibrillation
Authors: Sanghamitra Mohanty, Shuying Zhao, Austin Conney, Andrea Natale, Hongran Wang
Journal: Circulation (2018)

Introduction: Human induced pluripotent stem cells (iPSCs) have attracted considerable attention for disease modeling studies. However, there are rare instances when peripheral blood mononuclear ce...
Altered Motor and Motor Perceptual Cognitive Imagery Task–Related Activation in Diabetic Peripheral Neuropathy: Insights From Functional MRI
Authors: Kavita Venkataraman, Vivian Pun, Abdalla Z. Mohamed, Miyang Luo, Caroline Wong, Fangrong Zong, Eric Y.H. Khoo, E. Shyong Tai, Fatima Nasrallah
Journal: Diabetes Care (2019)

OBJECTIVE To compare central nervous system (CNS) activation in patients with and without diabetic peripheral neuropathy (DPN) during motor and motor imagery tasks and to correlate activation with functional performance. RESEARCH DESIGN AND METHODS Twenty-six participants (13 with DPN, 13 without DPN) underwent functional MRI during three tasks: ankle dorsi plantar flexion (motor task [MT]) and motor imagery tasks of walking on a smooth surface (SMIT) and rough surface (RMIT). Functional assessment included gait analysis, ankle muscle strength, and ankle range of motion. RESULTS The tasks activated the sensorimotor, motor preparation, visual processing, and decision-making regions. Activation was significantly lower in patients with DPN than in those without DPN during MT and SMIT but not RMIT. Poor functional performance in patients with DPN was associated with greater activation in motor preparation regions. CONCLUSIONS In patients with DPN, CNS responses appear muted compared with patients without DPN, but they remain capable of enhancing CNS activation when tasks are more challenging or when functional deficits are substantial.
Association Between Forced Sexual Initiation and Health Outcomes Among US Women
Authors: Laura Hawks, Steffie Woolhandler, David U. Himmelstein, David H. Bor, Adam Gaffney, Danny McCormick
Journal: JAMA Internal Medicine (2019)

The #MeToo movement has highlighted how frequently women experience sexual violence. However, to date, no recent studies have assessed the prevalence of forced sex during girls' and women's first sexual encounter or its health consequences.To estimate the prevalence of forced sexual initiation among US women and its association with subsequent reproductive, gynecologic, and general health outcomes.A cross-sectional analysis of the 2011-2017 National Survey of Family Growth was conducted, including a population-based sample of 13 310 US women. The study was conducted from September 2011 to September 2017.Self-reported forced vs voluntary first sexual intercourse.Prevalence of forced sexual initiation, age of woman and partner/assailant at first sexual encounter, and odds ratios (ORs) (adjusted for sociodemographic characteristics) for having an unwanted first pregnancy or abortion, development of painful pelvic conditions, and other reproductive and general health measures.A total of 13 310 women between the ages of 18 and 44 years were included in the study. After survey weights were applied, 6.5% (95% CI, 5.9%-7.1%) of respondents reported experiencing forced sexual initiation, equivalent to 3 351 733 women in this age group nationwide. Age at forced sexual initiation averaged 15.6 (95% CI, 15.3-16.0) years vs 17.4 (95% CI, 17.3-17.5) years for voluntary sexual initiation (P < .001). The mean age of the partner/assailant at first sexual encounter was 6 years older for women with forced vs voluntary sexual initiation (27.0; 95% CI, 24.8-29.2 years vs 21.0; 95% CI, 20.6-21.3 years). Compared with women with voluntary sexual initiation, women with forced sexual initiation were more likely to experience an unwanted first pregnancy (30.1% vs 18.9%; adjusted OR [aOR], 1.9; 95% CI, 1.5-2.4) or an abortion (24.1% vs 17.3%; aOR, 1.5; 95% CI, 1.2-2.0), endometriosis (10.4% vs 6.5%; aOR, 1.6; 95% CI, 1.1-2.3), pelvic inflammatory disease (8.1% vs 3.4%; aOR, 2.2; 95% CI, 1.5-3.4), and problems with ovulation or menstruation (27.0% vs 17.1%; aOR, 1.8; 95% CI, 1.4-2.3). Survivors of forced sexual initiation more frequently reported illicit drug use (2.6% vs 0.7%; aOR, 3.6; 95% CI, 1.8-7.0), fair or poor health (15.5% vs 7.5%; aOR, 2.0; 95% CI, 1.5-2.7), and difficulty completing tasks owing to a physical or mental health condition (9.0% vs 3.2%; aOR, 2.8; 95% CI, 2.0-3.9).Forced sexual initiation in women appears to be common and associated with multiple adverse reproductive and general health outcomes. These findings highlight the possible need for public health measures and sociocultural changes to prevent sexual violence, particularly forced sexual initiation.
Comparative Profiling of Serum Protein Biomarkers in Rheumatoid Arthritis–Associated Interstitial Lung Disease and Idiopathic Pulmonary Fibrosis
Authors: Daniel J. Kass, Mehdi Nouraie, Marilyn K. Glassberg, Nitya Ramreddy, Karen Fernandez, Lisa Harlow, Yingze Zhang, Jean Chen, Gail S. Kerr, Andreas M. Reimold, Bryant R. England, Ted R. Mikuls, Kevin F. Gibson, Paul F. Dellaripa, Ivan O. Rosas, Chester V. Oddis, Dana P. Ascherman
Journal: Arthritis & Rheumatology (2019)

Interstitial lung disease (ILD) is a frequent complication of rheumatoid arthritis (RA), occurring in up to 40% of patients during the course of their disease. Early diagnosis is critical, particularly given the shared clinicoepidemiologic features between advanced rheumatoid arthritis-associated ILD (RA-ILD) and idiopathic pulmonary fibrosis (IPF). This study was undertaken to define the molecular basis of this overlap through comparative profiling of serum proteins in RA-ILD and IPF.Multiplex enzyme-linked immunosorbent assays (ELISAs) were used to profile 45 protein biomarkers encompassing cytokines/chemokines, growth factors, and matrix metalloproteinases (MMPs) in sera obtained from RA patients with ILD and those without, individuals with IPF, and healthy controls. Levels of selected serum proteins were compared between patient subgroups using adjusted linear regression, principal component analysis (PCA), and least absolute shrinkage and selection operator (LASSO) modeling.Multiplex ELISA-based assessment of sera from 2 independent cohorts (Veterans Affairs [VA] and Non-VA) revealed a number of non-overlapping biomarkers distinguishing RA-ILD from RA without ILD (RA-no ILD) in adjusted regression models. Parallel analysis of sera from IPF patients also yielded a discriminatory panel of protein markers in models adjusted for age/sex/smoking, which showed differential overlap with profiles linked to RA-ILD in the VA cohort versus the Non-VA cohort. PCA revealed several distinct functional groups of RA-ILD-associated markers that, in the VA cohort, encompassed proinflammatory cytokines/chemokines as well as 2 different subsets of MMPs. Finally, LASSO regression modeling in the Non-VA and VA cohorts revealed distinct biomarker combinations capable of discriminating RA-ILD from RA-no ILD.Comparative serum protein biomarker profiling represents a viable method for distinguishing RA-ILD from RA-no ILD and identifying population-specific mediators shared with IPF.
Fibroblast Growth Factor 19–Mediated Up‐regulation of SYR‐Related High‐Mobility Group Box 18 Promotes Hepatocellular Carcinoma Metastasis by Transactivating Fibroblast Growth Factor Receptor 4 and Fms‐Related Tyrosine Kinase 4
Authors: Jie Chen, Feng Du, Yunzhi Dang, Xiaowei Li, Meirui Qian, Weibo Feng, Chenyang Qiao, Daiming Fan, Yongzhan Nie, Kaichun Wu, Limin Xia
Journal: Hepatology (2019)

Background and Aims The poor prognosis of patients with hepatocellular carcinoma (HCC) is mainly attributed to its high rate of metastasis and recurrence. However, the molecular mechanisms underlying HCC metastasis need to be elucidated. The SRY‐related high‐mobility group box (SOX) family proteins, which are a group of highly conserved transcription factors, play important roles in cancer initiation and progression. Here, we report on a role of SOX18, a member of the SOX family, in promoting HCC invasion and metastasis. Approach and Results The elevated expression of SOX18 was positively correlated with poor tumor differentiation, higher tumor‐node‐metastasis (TNM) stage, and poor prognosis. Overexpression of SOX18 promoted HCC metastasis by up‐regulating metastasis‐related genes, including fibroblast growth factor receptor 4 (FGFR4) and fms‐related tyrosine kinase 4 (FLT4). Knockdown of both FGFR4 and FLT4 significantly decreased SOX18‐mediated HCC invasion and metastasis, whereas the stable overexpression of FGFR4 and FLT4 reversed the decrease in cell invasion and metastasis that was induced by inhibition of SOX18. Fibroblast growth factor 19 (FGF19), which is the ligand of FGFR4, up‐regulated SOX18 expression. A mechanistic investigation indicated that the up‐regulation of SOX18 that was mediated by the FGF19‐FGFR4 pathway relied on the phosphorylated (p)‐fibroblast growth factor receptor substrate 2/p‐glycogen synthase kinase 3 beta/β‐catenin pathway. SOX18 knockdown significantly reduced FGF19‐enhanced HCC invasion and metastasis. Furthermore, BLU9931, a specific FGFR4 inhibitor, significantly reduced SOX18‐mediated HCC invasion and metastasis. In human HCC tissues, SOX18 expression was positively correlated with FGF19, FGFR4, and FLT4 expression, and patients that coexpressed FGF19/SOX18, SOX18/FGFR4, or SOX18/FLT4 had the worst prognosis. Conclusions We defined a FGF19‐SOX18‐FGFR4 positive feedback loop that played a pivotal role in HCC metastasis, and targeting this pathway may be a promising therapeutic option for the clinical management of HCC.
Global Effect of Childhood Cancers
Authors: Bridget Kuehn
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The prognostic significance of Cerb-B2 determination in gastric cancer.
Authors: Antonio CALDEIRA Fradique
Journal: Journal of Clinical Oncology (2012)

e14713 Background: The Cerb-B2/HER2 marker, is a glycoprotein encoded by the ERBB2 oncogene, belongs to the family of epidermal growth factor receptors (EGFR), which has based its application on tests of new therapeutic modalities (target therapy). Apart from this interest has been invoked its value as a marker of tumor aggressiveness, due to his role as a regulator of cell proliferation and migration and consequent invasiveness and metastization. However, the results as to the meaning prognosis of this molecular marker are controversial and with variations depending on the geographical zone. Results: From a total of 50 pts. with advanced resectable gastric cancer that underwent surgery with D2 lymphadenectomy, 38 pts. had a total gastrectomy, and 12 pts. had subtotal gastrectomy. A mean of 35.7 lymph nodes/pt were resected at surgery. In 68% of pts. positive lymph node metastases were present. Tumor HER2-neu overexpression was observed in 16 pts (32%), several other parameters of tumor aggressiveness were also present, without any statistical significance or relevance. Methods: To determine if the Cerb-B2 played a prognostic role in gastric cancer, a total of 50 pts. with advanced resectable gastric cancer, were submitted to gastrectomy with D2 lymphadenectomy. In all cases assessment for tumor HER2-neu overexpression was performed using immunohistochemistry (IHC). FISH was used as a confirmation method in tumors with 2+ expression by IHC. A correlation was made between the tumor HER2-neu expression and the following parameters: tumor location, size, histological type, depth of invasion, lymph node metastases and clinical staging. Results: From a total of 50 pts. with advanced resectable gastric cancer that underwent surgery with D2 lymphadenectomy, 38 pts. had a total gastrectomy, and 12 pts. had subtotal gastrectomy. A mean of 35.7 lymph nodes/pt were resected at surgery. In 68% of pts. positive lymph node metastases were present.Tumor HER2-neu overexpression was observed in 16 pts (32%), several other parameters of tumor aggressiveness were also present, without any statistical significance or relevance. Conclusions: The determination of Cerb-B2 / HER2 expression has not shown prognostic significance in this study.