tbuckley/cabot-search huggingface dataset:
Abstract 18022: Improved Assessment of CAD in Women With Flurpiridaz F-18 PET Myocardial Perfusion Imaging: Results of Subset Analysis of the Flurpiridaz F-18 Phase 3 Study
Authors: Gary V Heller, Jamshid Maddahi, James E Udelson, Robert Beanlands, Juhani Knuuti, Timothy M Bateman, Daniel S Berman, Joel Lazewatsky, Cesare Orlandi
Journal: Circulation (2015)

Background: Coronary artery disease (CAD) is under-diagnosed in women. Flurpiridaz F 18 injection (flurpiridaz) is a PET myocardial perfusion imaging (MPI) tracer in clinical development. We hypothesized flurpiridaz would result in improved CAD detection in women in comparison to SPECT. Methods: This Phase 3 study was designed to assess the diagnostic efficacy of flurpiridaz and SPECT with Tc99m-labeled agents for CAD detection in the same patients. Patients with known or suspected CAD who were either scheduled for or had completed invasive coronary angiography (without intervention) were included. Each patient was studied using both rest/stress flurpiridaz PET MPI and rest/stress Tc-99m labeled SPECT MPI. Images were interpreted by 3 expert readers blinded to all clinical information. Quantitative coronary angiography (QCA) was used with patients considered CAD positive with a stenosis ≥50% in at least one major vessel. Results: 795 subjects were enrolled at 72 clinical sites in US, Canada and Finland. The study included 235 (30%) evaluable female subjects with a mean age of 62.4±10.1 years, body weight of 85.0±21.6 kg, and a BMI of 32.3±7.8 (58.7% with a BMI≥30). The agent was safe and well tolerated. A statistically significant greater sensitivity was seen for flurpiridaz (67.8%) vs SPECT (37.3%, p&lt;0.001). Similar specificity was shown for flurpiridaz (81.3%) vs SPECT (80.1%) (p=0.017 for non-inferiority testing). The diagnostic superiority of flurpiridaz vs SPECT was also demonstrated by ROC analysis (p&lt;0.001). Statistical superiority of flurpiridaz vs SPECT was shown for diagnostic accuracy (p=0.014), image quality (p&lt;0.001), and interpreter certainty (p&lt;0.001), with a significant reduction (~50%) in radiation exposure for flurpiridaz vs SPECT (p&lt;0.001). Conclusions: The results of this Phase 3 trial demonstrate the superiority of flurpiridaz over standard SPECT MPI for the assessment of CAD in women, with lower radiation exposure than standard SPECT.
Treatment of anemia in myelodysplastic syndromes with prolonged administration of erythropoietin or erythropoietin and granulocyte colony-stimulating factor
Authors: Evangelos Terpos, Athina Mougiou, Niki Stavroyianni, Alexandra Kouraklis, Nikolaos Giannakoulas, Nicholas C. Zoumbos, Aria Hatzivassili, Olga Liapi, Maria Vassilaki, Konstantinos L. Bourantas, Evridiki Michalis, Nikolaos I. Anagnostopoulos, Nikolaos P. Laoutaris, Eleni Manioudaki, Maria Protopappa, Vassiliki Bakaloudi, John I. Christakis, Elissavet Grouzi, Nora Athina Viniou
Journal: Blood (2000)
Abstract 15714: Prediction of Sudden Cardiac Death With Automated High-Throughput Analysis of T-Wave Heterogeneity in Standard 12-Lead Electrocardiogram
Authors: Tuomas Kenttä, Bruce D Nearing, Kimmo Porthan, Jani T Tikkanen, Matti Viitasalo, Markku S Nieminen, Veikko Salomaa, Lasse Oikarinen, Heikki V Huikuri, Richard L Verrier
Journal: Circulation (2014)

Introduction: Noninvasive identification of patients at risk for sudden cardiac death (SCD) remains a major clinical challenge. Abnormal ventricular repolarization is associated with increased risk of lethal ventricular arrhythmias and SCD. Hypothesis: We investigated the hypothesis that spatial repolarization heterogeneity can identify patients at risk for SCD in general population. Methods: Spatial R-, J- and T-wave heterogeneities (RWH, JWH and TWH, respectively) were automatically analyzed with second central moment technique from standard digital 12-lead ECGs in 5618 adults (46% men; age 50.9±12.5 yrs.) who took part in Health 2000 Study, an epidemiological survey representative of the entire Finnish adult population. During average follow-up of 7.7±1.4 years, a total of 72 SCDs occurred. Thresholds of RWH, JWH and TWH were based on optimal cutoff points from ROC curves. Results: Increased RWH, JWH and TWH (Fig.1) in left precordial leads (V4-V6) were univariately associated with SCD (P&lt;0.001, each). When adjusted with clinical risk markers (age, gender, BMI, systolic blood pressure, cholesterol, heart rate, left ventricular hypertrophy, QRS duration, arterial hypertension, diabetes, coronary heart disease and previous myocardial infarction) JWH and TWH remained as independent predictors of SCD. Increased TWH (≥102μV) was associated with a 1.9-fold adjusted relative risk (95% confidence interval [CI]: 1.2 - 3.1; P=0.011) and increased JWH (≥123μV) with a 2.0-fold adjusted relative risk for SCD (95% CI: 1.2 - 3.3; P=0.004). When both TWH and JWH were above threshold, the adjusted relative risk for SCD was 3.2-fold (95% CI: 1.7 - 6.2; P&lt;0.001). When all heterogeneity measures (RWH, JWH and TWH) were above threshold, the risk for SCD was 3.7-fold (95% CI: 1.6 - 8.6; P=0.003). Conclusions: Automated measurement of spatial J- and T-wave heterogeneity enables analysis of high patient volumes and is able to stratify SCD risk in general population.
Abstract 12131: LMO2 Regulates Endothelial Proliferation, Angiogenesis and Tissue Regeneration
Authors: Shu Meng, Gianfranco Matrone, Wing tak Wong, John Cooke
Journal: Circulation (2016)

Introduction: LIM domain only 2 (LMO2) is a key transcription factor of embryonic angiogenesis. However, its role in adult endothelial function and tissue regeneration is unclear. Methods: In vitro loss- and gain-of-function studies on LMO2 were performed in human umbilical vein endothelial cells (HUVEC) with lentiviral overexpression (OE) or shRNA knock down (KD) of LMO2 respectively. LMO2 gene expression and protein level was examined by RT-PCR and western blot respectively. Cell cycle was examined by PI staining and FACS analysis. Angiogenesis was examined by network formation assay on matrigel. ChIP-PCR was used to examine the LMO2 complex binding to chromatin. Vascular and tissue regeneration was examined by caudal fin regeneration in zebrafish model. Results: LMO2 KD impaired endothelial proliferation and angiogenesis. LMO2 controls the G1/S transition in endothelial cells through transcriptional regulation of CDK2 and CDK4 examined by RT, western blot and ChIP, and also influences the expression of CyclinD1 and Cyclin A1. LMO2 KD downregulated a network of angiogenic genes. Among them, LMO2 regulated TGFβ through binding to the proximal promoter of TGFB1. In a zebrafish model of caudal fin regeneration, lmo2 gene was upregulated at day 5 post resection. In this model, lmo2 KD by vivo-morpholino injection reduced BrdU incorporation in endothelial cells, impaired neoangiogenesis, and substantially delayed caudal fin regeneration. Conclusions: LMO2 is a critical transcription factor regulating adult endothelial proliferation and angiogenesis, and in adult animals regulates vascular and tissue regeneration.
Abstract 16128: Activation of Lung p53 by Non-Receptor Tyrosine Kinase Pyk2 Inhibition Suppresses Pulmonary Arterial Hypertension(PAH)
Authors: Kuniyoshi Fukai, Akihiro Nakamura, Motoki Uchihashi, Satoshi Kaimoto, Makoto Ariyoshi, Yoshifumi Okawa, Atsushi Hoshino, Maki Katamura, Eri Kanai, Satoaki Matoba
Journal: Circulation (2013)

Background: PAH is an idiopathic refractory diseases characterized by uncontrolled vascular remodeling and increasing pulmonary arterial pressure. The therapies have been focused on regulating vaso...
Abstract 13438: Specific Circulating Microparticle Components Secreted in Heart Failure Are New Targets of Ivabradine
Authors: Rafael Ramirez-Carracedo, Marina Pascual, Paula Reventun, Irene Cuadrado, Ignacio Hernandez, Javier Diez, Jose-Luis Zamorano, Marcelo Sanmartin, Marta Saura, Carlos Zaragoza
Journal: Circulation (2017)

Introduction: High resting heart rate (HR) is a risk factor in heart failure (HF) patients with reduced left ventricle ejection fraction. Patients secrete circulating microparticles loaded with sub...
Targeted Alpha Therapy with 212Pb-NNV003 for the Treatment of CD37 Positive B-Cell Chronic Lymphocytic Leukemia (CLL) and Non-Hodgkin Lymphoma (NHL)
Authors: Amal Saidi, Astri Maaland, Julien Torgue, Helen Heyerdahl, Jostein Dahle
Journal: Blood (2018)
Hand Sanitizer Combated Sickness in Day Care Centers
Authors: Anita Slomski
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Case Report: Acetylcholine Spasm Provocation Test By Trans-Radial Artery And Vein Approach
Authors: Shozo Sueda, Hiroaki Kohno, Hirokazu Habara, Kaori Fujimoto
Journal: Clinical Cardiology and Cardiovascular Interventions (2018)

70-year-old man admitted to our hospital because of chest discomfort on effort. Because we inserted the 6 Fr sheath into the wrong radial vein, we replaced the 5 Fr sheath into the radial vein. We inserted the 6 Fr sheath into the radial artery. We performed the acetylcholine and ergonovine spasm provocation tests under the temporary pace maker insertion. After the procedures, we compressed the radial artery and vein with radial band simultaneously. No bleeding or hematoma was found after the removal of radial band. We could perform the acetylcholine test via the radial artery and vein without any complications.
Abstract 18880: Inflammation Imaged With [18F]-FDG PET/CTA is Related to 3D Ultrasound Phenotypes of High-risk Carotid Plaque: Sub-study of the Canadian Atherosclerosis Imaging Network (CAIN-2)
Authors: Myra S Cocker, Aaron Fenster, Robert R Hammond, Siok P Lim, Robert A deKemp, Cheemun Lum, Andrew Hill, Sudhir Nagpal, Grant Stotts, Brittany Warren, Linda Garrard, Jean DaSilva, Jean-Claude Tardif, Rob S Beanlands, J. David Spence
Journal: Circulation (2015)

Background: Inflammation may contribute to plaque instability. [18F]-fluorodeoxyglucose (FDG) uptake imaged with positron emission tomography (PET) and computed tomography (CT) may serve as a biomarker of plaque inflammation. 3-dimensional ultrasound (U/S)-derived total plaque volume (TPV) and vessel wall volume (VWV) are measures of plaque volume and vessel wall thickness that are used for monitoring progression and regression of carotid atherosclerosis. Progression of TPV has been related to cardiovascular events. The volumetric phenotype (TPV and VWV) and extent of the inflammatory burden (FDG uptake) may independently predict carotid plaque vulnerability. However, the interrelationship between FDG uptake and measures of TPV and VWV remains poorly understood. Methods: Thirty-seven patients (67±9 years, 9 female) scheduled for carotid endarterectomy were prospectively recruited for 3D U/S and FDG PET/CT imaging of the left and right internal carotid arteries. Maximum FDG uptake normalized to blood (tissue to blood ratio - TBR) was measured for bilateral carotid plaque. Manual planimetry was used to measure bilateral TPV and VWV. Each 3-D image were evaluated from the bifurcation to the common carotid, and then to the internal and external carotid arteries. Results: Maximum FDG uptake correlated with TPV (r=0.42, p&lt;0.001) and VWV (r=0.30, p=0.015) (Figure 1). FDG uptake was greater in plaque scheduled for endarterectomy (TBR=3.6±1.3 endarterectomy vs. 3.0±1.2 contralateral, p=0.049). There was also a trend for greater TPV at the side of endarterectomy: 799±390mm 3 endarterectomy vs. 672±150mm 3 contralateral (p=0.088). Conclusion: FDG uptake in high-risk carotid plaque is related to TPV and VWV. The inflammatory burden and the volumetric phenotype of plaque may synergistically provide a more robust evaluation of plaque vulnerability. Longitudinal follow-up for the assessment of plaque progression in this study cohort is currently underway.
Functional characterization of MUC17 in pancreatic adenocarcinoma cells
Authors: Wade Junker, Surinder Batra
Journal: Cancer Research (2008)

1938  Mucin glycoproteins are implicated in various cancer types and are being actively studied due to their deregulated expression patterns, which can differentiate normal tissues from their malignant counterparts. Of particular interest is our recently characterized mucin 17 (MUC17), a membrane-anchored glycoprotein that is normally expressed in the gastrointestinal tract. We have reported that MUC17 is aberrantly expressed in pancreatic tumor cells and tumor cell lines with no expression detected in the normal pancreas or in benign pancreatitis tissues (Moniaux N., et al. 2006, 281, 23676-23685). Therefore, our working hypothesis is that MUC17 is implicated in the pathogenesis of pancreatic cancer. The MUC17 gene encodes a message of 14.4 Kb. Due to the large size of MUC17, a retroviral system was used to express a stable MUC17-specific RNAi that knocked down expression in the MUC17 expressing AsPC-1 pancreatic adenocarcinoma cell line. Both single colony clones and clonal populations of knock-down cells were assessed alongside parental AsPC-1 or AsPC-1 cells expressing a stable scrambled RNAi sequence. MUC17 knocked down cell lines displayed increased growth kinetics with reduced doubling time. Adhesion to cell culture surface was similar between knock-down and control populations; however, an increased motility was observed in the absence of MUC17 (motility and wound-healing assays). Knock-down and control population cell lines showed similar aggregation in hanging drop aggregation assays. No difference was observed in tests for clonogenic potential or in soft agar assays for tumorigenic potential. Xenotransplantation of the AsPC-1 cell line/model produces tumors with differentiation ranging from well to poorly differentiated adenocarcinomas. In the absence of MUC17, increased tumor weights were observed; however, no statistical difference between clonal populations of parental and knock-down (p=.1967) or scrambled and knock-down (p=.3772) cell lines was detected due to a large variance among tumor weights. In conclusion, our in vitro and in vivo results show that the absence of MUC17 in the AsPC-1 pancreatic model results in a pattern of increased tumorigenic potential. MUC17 expression in pancreatic cancer may therefore be an attempt to prevent tumorigenic growth or could be a surrogate consequence of altered signaling pathways in the cancerous state. The potential for MUC17 to mediate adhesion while conveying outside signals to the intracellular machinery is great. Microarray analysis and mechanistic study of scrambled versus knock-down populations will be performed. Additionally, a pancreas-specific mouse model, in which K-Ras is genetically inactivated and results in pancreatic cancer, is under development. The model will be used to assess the role of the MUC17 mouse homologue mMUC17 (work, in part, was supported by the NIH grants UO1 CA 111294 and T32 CA09476).
Abstract 16986: Mechanism of Atrial Mitral Regurgitation -An Echocardiographic Study-
Authors: Takafumi Nagaura, Atsushi Hayashi, Satoshi Yamaguchi, Tetsuo Kamiyama, Florian Rader, Saibal Kar, Rober J Siegel, Takahiro Shiota
Journal: Circulation (2017)

Introduction: The purpose of this study was to investigate potential causes of mitral regurgitation (MR) in chronic atrial fibrillation using real-time three-dimensional transesophageal echocardiog...
The Language of Suicide
Authors: Phoebe Danziger
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Survival Analysis from the CALGB Study of Lenalidomide Maintenance Therapy in Newly Diagnosed Multiple Myeloma Post-Autologous Stem Cell Transplantation Adjusted for Crossover (Alliance 100104)
Authors: Philip L. McCarthy, Paul Richardson, Vera Suman, Miranda Cooper, Owain Saunders, Sujith Dhanasiri, Sergio Giralt, Kenneth Anderson, Edward Stadtmauer, Sarah A. Holstein
Journal: Blood (2018)
Effect of the Bolsa Familia Programme on the outcome of tuberculosis treatment: a prospective cohort study
Authors: Janaina Gomes Nascimento Oliosi, Barbara Reis-Santos, Rodrigo Leite Locatelli, Carolina Maia Martins Sales, Walter Gomes da Silva Filho, Kerollen Cristina da Silva, Mauro Niskier Sanchez, Kaio Vinicius Freitas de Andrade, Gleide Santos de Araújo, Priya B Shete, Susan Martins Pereira, Lee W Riley, Christian Lienhardt, Ethel Leonor Noia Maciel
Journal: The Lancet Global Health (2018)

Social protection interventions might improve tuberculosis outcomes and could help to control the epidemic in Brazil. The aim of this study was to evaluate the independent effect of the Bolsa Familia Programme (BFP) on tuberculosis treatment outcomes in Brazil.We prospectively recruited and followed up individuals (aged ≥18 years) who initiated tuberculosis treatment at 42 health-care centres across seven cities in Brazil, between March 1, 2014, and April 30, 2017. Patients were interviewed at health-care centres and information about individual characteristics, socioeconomic status, living conditions, lifestyle, and comorbidities was recorded. Patients were separated into two groups according to BFP beneficiary status: BFP (exposed) or non-BFP (not exposed). Treatment outcome (cure, dropout, death, or development of drug-resistant tuberculosis or treatment failure) was recorded after 6 months of therapy. Pearson's χ2 test and ANOVA were used to compare tuberculosis treatment outcomes between the two groups, and we estimated the propensity score of being a beneficiary of the BFP using a logit model. We used multinomial regression models to evaluate the effect of the BFP on tuberculosis treatment outcomes.1239 individuals were included in the study, of whom 196 (16%) were beneficiaries of the BFP and 1043 (84%) were not. After 6 months of treatment, 912 (87%) of 1043 patients in the non-BFP group and 173 (88%) of 196 patients in the BFP group were cured of tuberculosis, 103 (10%) patients in the non-BFP group and 17 (9%) patients in the BFP group had dropped out, and 25 (3%) patients in the non-BFP group and six (3%) patients in the BFP group had died. Three (<1%) of 1043 patients in the non-BFP group developed drug-resistant tuberculosis. Being a BFP beneficiary had a positive effect for cure (average effect 0·076 [95% CI 0·037 to 0·11]) and a negative effect for dropout (-0·070 [-0·105 to 0·036]) and death (-0·002 [-0·021 to 0·017]).BFP alone had a direct effect on tuberculosis treatment outcome and could greatly contribute to the goals of the WHO End TB Strategy.Brazilian National Council for Scientific and Technological Development (CNPq) and Brazilian Ministry of Health Department of Science and Technology (DECIT).
Epigenetic Silencing of miRNA-338-5p and miRNA-421 Drives SPINK1-Positive Prostate Cancer
Authors: Vipul Bhatia, Anjali Yadav, Ritika Tiwari, Shivansh Nigam, Sakshi Goel, Shannon Carskadon, Nilesh Gupta, Apul Goel, Nallasivam Palanisamy, Bushra Ateeq
Journal: Clinical Cancer Research (2018)

Serine peptidase inhibitor, Kazal type-1 (SPINK1) overexpression defines the second most recurrent and aggressive prostate cancer subtype. However, the underlying molecular mechanism and pathobiology of SPINK1 in prostate cancer remains largely unknown.miRNA prediction tools were employed to examine the SPINK1-3'UTR for miRNA binding. Luciferase reporter assays were performed to confirm the SPINK1-3'UTR binding of shortlisted miR-338-5p/miR-421. Furthermore, miR-338-5p/-421-overexpressing cancer cells (SPINK1-positive) were evaluated for oncogenic properties using cell-based functional assays and a mouse xenograft model. Global gene expression profiling was performed to unravel the biological pathways altered by miR-338-5p/-421. IHC and RNA in situ hybridization were carried out on prostate cancer patients' tissue microarray for SPINK1 and EZH2 expression, respectively. Chromatin immunoprecipitation assay was performed to examine EZH2 occupancy on the miR-338-5p/-421-regulatory regions. Bisulfite sequencing and methylated DNA immunoprecipitation were performed on prostate cancer cell lines and patients' specimens.We established a critical role of miRNA-338-5p/-421 in posttranscriptional regulation of SPINK1. Ectopic expression of miRNA-338-5p/-421 in SPINK1-positive cells abrogates oncogenic properties including cell-cycle progression, stemness, and drug resistance, and shows reduced tumor burden and distant metastases in a mouse model. Importantly, we show that patients with SPINK1-positive prostate cancer exhibit increased EZH2 expression, suggesting its role in epigenetic silencing of miRNA-338-5p/-421. Furthermore, presence of CpG dinucleotide DNA methylation marks on the regulatory regions of miR-338-5p/-421 in SPINK1-positive prostate cancer cells and patients' specimens confirms epigenetic silencing.Our findings revealed that miRNA-338-5p/-421 are epigenetically silenced in SPINK1-positive prostate cancer, although restoring the expression of these miRNAs using epigenetic drugs or synthetic mimics could abrogate SPINK1-mediated oncogenesis.See related commentary by Bjartell, p. 2679.