tbuckley/cabot-search huggingface dataset:
Intratumoral injection reduces toxicity and antibody-mediated neutralization of immunocytokine in a mouse melanoma model
Authors: Claire C Baniel, Elizabeth G Sumiec, Jacqueline A Hank, Amber M Bates, Amy K Erbe, Alexander A Pieper, Anna G Hoefges, Ravi B Patel, Alexander L Rakhmilevich, Zachary S Morris, Paul M Sondel
Journal: Journal for ImmunoTherapy of Cancer (2020)

Some patients with cancer treated with anticancer monoclonal antibodies (mAbs) develop antidrug antibodies (ADAs) that recognize and bind the therapeutic antibody. This response may neutralize the therapeutic mAb, interfere with mAb effector function or cause toxicities. We investigated the potential influence of ADA to modify the tumor-binding capability of a tumor-reactive 'immunocytokine' (IC), namely, a fusion protein (hu14.18-IL2) consisting of a humanized, tumor-reactive, anti-GD2 mAb genetically linked to interleukin 2. We characterize the role of treatment delivery of IC (intravenous vs intratumoral) on the impact of ADA on therapeutic outcome following IC treatments in an established antimelanoma (MEL) regimen involving radiotherapy (RT) +IC.C57BL/6 mice were injected with human IgG or the hu14.18-IL2 IC to develop a mouse anti-human antibody (MAHA) response (MAHA+). In vitro assays were performed to assess ADA binding to IC using sera from MAHA+ and MAHA- mice. In vivo experiments assessed the levels of IC bound to tumor in MAHA+ and MAHA- mice, and the influence of IC route of delivery on its ability to bind to B78 (GD2+) MEL tumors.MAHA is inducible in C57BL/6 mice. In vitro assays show that MAHA is capable of inhibiting the binding of IC to GD2 antigen on B78 cells, resulting in impaired ADCC mediated by IC. When B78-bearing mice are injected intravenously with IC, less IC binds to B78-MEL tumors in MAHA+ mice than in MAHA- mice. In contrast, when IC is injected intratumorally in tumor-bearing mice, the presence of MAHA does not detectibly impact IC binding to the tumor. Combination therapy with RT+IT-IC showed improved tumor regression compared with RT alone in MAHA+ mice. If given intratumorally, IC could be safely readministered in tumor-bearing MAHA+ mice, while intravenous injections of IC in MAHA+ mice caused severe toxicity. Histamine levels were elevated in MAHA+ mice compared with MAHA- mice after reintroduction of IC.Intratumoral injection may be a means of overcoming ADA neutralization of therapeutic activity of tumor-reactive mAbs or ICs and may reduce systemic toxicity, which could have significant translational relevance.
Combination of Idasanutlin, Venetoclax and Obinutuzumab in Patients with Relapsed or Refractory (R/R) Non-Hodgkin Lymphoma (NHL): Results from a Phase I/II Study
Authors: Manali Kamdar, Bradley Augustson, Young Rok Do, James Edwards, Mark Hertzberg, Amanda Johnston, Jin Seok Kim, Frank P. Kroschinsky, Sonali M. Smith, Don A. Stevens, Annabelle Monnet, Ye Zhao, Yann Nouet, Viktoriya Marinova
Journal: Blood (2020)
Quality indicators for appropriate antimicrobial therapy in the emergency department: a pragmatic Delphi procedure
Authors: Teske Schoffelen, Jeroen Schouten, Jacobien Hoogerwerf, Alejandro Martín Quirós, Larissa May, Jaap Ten Oever, Marlies Hulscher
Journal: Clinical Microbiology and Infection (2020)

ObjectivesAntimicrobial stewardship (AMS) has established its importance for inpatient care. AMS is, however, also urgently needed in emergency departments (ED), where many antimicrobial prescriptions are initiated. It is currently unclear what metrics stewardship teams can use to measure and improve the appropriateness of antimicrobial prescription in the ED. In this study we develop quality indicators (QIs) for antimicrobial use in the ED.MethodsA RAND-modified Delphi procedure was used to develop a set of QIs applicable to adult patients who present at the ED with a potential infection. First, pragmatically using two recent papers of the international expert-group DRIVE-AB, potential ED-specific QIs for appropriate antimicrobial use were retrieved. Thereafter, an international multidisciplinary expert panel appraised these QIs during two questionnaire rounds with a meeting in between.ResultsThirty-three potential QIs were extracted from the DRIVE-AB papers. After appraisal by 13 experts, 22 QIs describing appropriate antimicrobial use in the ED were selected. These indicators provide recommendations within five domains: stewardship prerequisites (six QIs); diagnostics (one QI); empirical treatment (ten QIs); documentation of information (four QIs); and patient discharge (one QI).ConclusionsWe pragmatically developed a set of 22 QIs that can be used by stewardship teams to measure the appropriateness of antimicrobial prescription in the ED. There is probably room for additional QI development to cover all key aspects of AMS in the ED. Measuring QIs can be a first step for stewardship teams to, in collaboration with ED professionals, choose targets for improvement and optimize antimicrobial use.
DETERMINANTS OF QUALITY OF LIFE IN MULTIPLE MYELOMA PATIENTS: CROATIAN EXPERIENCE
Authors: Vibor Milunović, Klara Zalac, Hrvoje Brcić, Romyna Zimak, Karla Mišura Jakobac, Inga Mandac Rogulj, Marin Kursar, Marko Martinović, Delfa Radić Krišto, Slobodanka Ostojić Kolonić
Journal: HemaSphere (2020)
Azacitidine (AZA) with Nivolumab (Nivo), and AZA with Nivo + Ipilimumab (Ipi) in Relapsed/Refractory (R/R) Acute Myeloid Leukemia: Clinical and Immune Biomarkers of Response
Authors: Naval Daver, Sreyashi Basu, Guillermo Garcia-Manero, Hussein A Abbas, Marina Konopleva, Tapan M. Kadia, Courtney D. DiNardo, Gautam Borthakur, Ahmad S. Alotaibi, Naveen Pemmaraju, Elias Jabbour, Sherry A. Pierce, Mark Brandt, Koichi Takahashi, Jing Ning, Steven M. Kornblau, Koji Sasaki, Musa Yilmaz, Ghayas C. Issa, Nicholas J. Short, Jairo A. Matthews, Wilmer Flores, Michael Andreeff, Jorge E. Cortes, Farhad Ravandi, James P Allison, Hagop M. Kantarjian, Padmanee Sharma
Journal: Blood (2020)
Role of Aberrant Spontaneous Neurotransmission in SNAP25-Associated Encephalopathies
Authors: Baris Alten, Qiangjun Zhou, Ok-Ho Shin, Luis Esquivies, Pei-Yi Lin, K. Ian White, Rong Sun, Wendy K. Chung, Lisa M. Monteggia, Axel T. Brunger, Ege T. Kavalali
Journal: Neuron (2020)
Should Epidural Analgesia Be Abandoned for Open Pancreatoduodenectomy?—Reply
Authors: Rosa Klotz, Jan Larmann, Phillip Knebel
Journal: JAMA Surgery (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Idecabtagene Vicleucel (ide-cel, bb2121) Responses Are Characterized By Early and Temporally Consistent Activation and Expansion of CAR T Cells with a T Effector Phenotype
Authors: Nathan Martin, Ethan G. Thompson, Will Brown, Olivia Finney, Julie Rytlewski, Yue Jiang, Dipen Sangurdekar, Julie Wang, Hans Bitter, Ronald J. Hause, Timothy B. Campbell, Kristen Hege, Shari Kaiser
Journal: Blood (2020)
Plasma Short Chain Fatty Acids As a Predictor of Response to Therapy for Life-Threatening Acute Graft-Versus-Host Disease
Authors: Parth Gandhi, Isha Gandhi, Andrea Hoeschen, Wes Mosher, Margaret L. MacMillan, Armin Rashidi, Najla H El Jurdi, Alexander Khoruts, Daniel J. Weisdorf, Bruce R. Blazar, Qing Cao, Brian C. Betts, Angela Panoskaltsis-Mortari, Chi Chen, Shernan G Holtan
Journal: Blood (2020)
A Randomized Study of Pretransplant Conditioning Therapy for AML/MDS with Fludarabine ± Clofarabine and Once Daily IV Busulfan with Allogeneic Hematopoietic Transplantation for AML and MDS
Authors: Borje S. Andersson, Peter Thall, Benigno C. Valdez, Junsheng Ma, Julianne Chen, Sairah Ahmed, Amin M. Alousi, Qaiser Bashir, Stefan O. Ciurea, Alison Gulbis, Chitra Hosing, Roy B. Jones, Jitesh Kawedia, Partow Kebriaei, Steven M. Kornblau, Alan Myers, Betul Oran, Katayoun Rezvani, Nina Shah, Elizabeth J. Shpall, Simrit Parmar, Uday R. Popat, Yago Nieto, Richard E. Champlin
Journal: Blood (2020)
Constipation in Patients With Symptoms of Gastroparesis: Analysis of Symptoms and Gastrointestinal Transit
Authors: Henry P. Parkman, Emily Sharkey, Richard W. McCallum, William L. Hasler, Kenneth L. Koch, Irene Sarosiek, Thomas L. Abell, Braden Kuo, Robert J. Shulman, Madhusudan Grover, Gianrico Farrugia, Ron Schey, James Tonascia, Frank Hamilton, Pankaj J. Pasricha
Journal: Clinical Gastroenterology and Hepatology (2020)
Circulating Omega-3 Fatty Acids and Incident Adverse Events in Patients With Acute Myocardial Infarction
Authors: Iolanda Lázaro, Ferran Rueda, Germán Cediel, Emilio Ortega, Cosme García-García, Aleix Sala-Vila, Antoni Bayés-Genís
Journal: Journal of the American College of Cardiology (2020)

Dietary omega-3 eicosapentaenoic acid (EPA) has multiple cardioprotective properties. The proportion of EPA in serum phosphatidylcholine (PC) mirrors dietary EPA intake during previous weeks. Circulating EPA in ST-segment elevation myocardial infarction (STEMI) relates to smaller infarct size and preserved long-term ventricular function.The authors investigated whether serum-PC EPA (proxy for marine omega-3 consumption) levels at the time of STEMI were associated with a lower incidence of major adverse cardiovascular events (MACE), all-cause mortality, and readmission for cardiovascular (CV) causes at 3 years' follow-up. We also explored the association of alpha-linolenic acid (ALA, proxy for vegetable omega-3 intake) with all-cause mortality and MACE.The authors prospectively included 944 consecutive patients with STEMI (mean age 61 years, 209 women) undergoing primary percutaneous coronary intervention. We determined serum-PC fatty acids with gas chromatography.During follow-up, 211 patients had MACE, 108 died, and 130 were readmitted for CV causes. A Cox proportional hazards model adjusted for known clinical predictors showed that serum-PC EPA at the time of STEMI was inversely associated with both incident MACE and CV readmission (hazard ratio [HR]: 0.76; 95% confidence interval [CI]: 0.62 to 0.94, and HR: 0.74; 95% CI: 0.58 to 0.95, respectively, for a 1-standard deviation [SD] increase). Serum-PC ALA was inversely related to all-cause mortality (HR: 0.65; 95% CI: 0.44 to 0.96, for a 1-SD increase).Elevated serum-PC EPA and ALA levels at the time of STEMI were associated with a lower risk of clinical adverse events. Consumption of foods rich in these fatty acids might improve the prognosis of STEMI.
TGF-β induced activation of ERK regulates Smad degradation
Authors: Chris Hough, Jules J. Doré
Journal: Cancer Research (2006)

2697  The Transforming Growth Factor-Beta (TGF-β) family is a collection of structurally related peptides that include Activins, Bone Morphogenic Proteins (BMP), as well as the TGF-β’s. These growth factors are involved in a variety of cellular processes such as apoptosis, differentiation, and proliferation. TGF-β binding to its Serine/Threonine kinase receptor causes the recruitment and subsequent activation of transcription factors known as Smad2 and Smad3. These normally cytoplasmic proteins translocate into the nucleus and either negatively or positively regulate gene expression. TGF-β effects on proliferation depend on the cell type involved, as growth is stimulated in mesenchymal cells but inhibited in epithelial cells. Here we report that in addition to activating the Smad signaling pathway, TGF-β directly induces the phosphorylation of Extracellular Signal Regulated Kinase (Erk) in fibroblasts, but not in epithelial cells. The activation occurs through phosphotidylinositol 3-Kinase (PI3-K). TGF-β triggered Erk activation is dependant on Mek1/2 activity, as Mek inhibition abolishes Erk phosphorylation. However, TGF-β stimulated Erk activation appears to differ from the classical Ras/Raf/Mek/MAPK (mitogen activated protein kinase) signaling pathway in that the inhibition of Ras farnesylation does not inhibit Erk phosphorylation. Furthermore, TGF-β stimulation results in Raf-1 phosphorylation at S338, a site associated with Raf-1 activation. It has been shown that Smad2 and Smad3 contain MAPK/CDK phosphorylation sites. Phosphorylation of these sites is thought to regulate Smad nuclear translocation and/or transcriptional activity. TGF-β stimulated phosphorylation of the MAPK sites within the Smad2 linker region appears to be Erk dependant and occurs predominantly in the nucleus. This phosphorylation event is necessary for nuclear Smad proteasomal degradation as treatment with the proteasome inhibitor MG132 results in elevated phosphorylated Smad protein levels. Together, this data shows a new TGF-β dependant pathway leading to the activation of Erk which interacts with and regulates the classical Smad signaling pathway.
HESTER: A Phase II Study Evaluating Efficacy and Safety of Tisagenlecleucel Reinfusion in Pediatric and Young Adult Patients with Acute Lymphoblastic Leukemia Experiencing Loss of B-Cell Aplasia
Authors: Michael W Boyer, Sonali Chaudhury, Kara L Davis, Timothy Alan Driscoll, Stephan A Grupp, Michelle Hermiston, Samuel John, Amy K Keating, Christina Kovacs, Andrea Magley, Gary Douglas Myers, Christine L Phillips, Michael A Pulsipher, Das Purkayastha, Julie-An Talano, Jennifer Willert
Journal: Blood (2020)
High Throughput Genomic Analysis Identifies Low-Risk Smoldering Multiple Myeloma
Authors: Anil Aktas-Samur, Mariateresa Fulciniti, Sanika Derebail, Raphael Szalat, Giovanni Parmigiani, Jill Corre, Herve Avet-Loiseau, Mehmet K. Samur, Nikhil C. Munshi
Journal: Blood (2020)
Novel Insight into Multi-Hit Multiple Myeloma Based on "Two-Hit" Theory of Cancer Causation
Authors: Chenxing Du, Xue-Han Mao, Jiahui Liu, Huishou Fan, Weiwei Sui, Shuhui Deng, Shuhua Yi, Wenyang Huang, Yan Xu, Chengwen Li, Jiawei Zhao, Dehui Zou, Yaozhong Zhao, Jianxiang Wang, Lugui Qiu, Gang An
Journal: Blood (2020)
Mutations in <i>CRBN</i> and Other Cereblon Pathway Genes Are Only Associated with Acquired Resistance to Immunomodulatory Drugs in a Subset of Patients and Cell Line Models
Authors: Amy Barber, John R Jones, Harvey Che, Yann-Vai Le Bihan, Niels Weinhold, Cody Ashby, Brian A Walker, Christopher P. Wardell, Hannah Wang, Martin F. Kaiser, Graham H Jackson, Faith E. Davies, Rajesh Chopra, Gareth Morgan, Charlotte Pawlyn
Journal: Blood (2020)
Clinical Outcomes of Non-Traditional Lenalidomide, Bortezomib, and Dexamethasone Regimens in Multiple Myeloma
Authors: Shawn O. Streeter, Omar Nadeem, Paul G. Richardson, Jacob P. Laubach, Clifton C. Mo, Kimberly Noonan, Mary McKenney, Tina Flaherty, Virginia Dalton, Anil Aktas-Samur, Houry Leblebjian
Journal: Blood (2020)
THU0118 Sequential ep1 and ep4 regulation in a rabbit model of antigen-induced arthritis
Authors: I Diez-Ortego, R Largo, O Sanchez-Pernaute, R Guerrero, MJ Lopez-Armada, I Palacios, J Egido, G Herrero-Beaumont
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> Prostaglandin E2 (PGE2) exerts its actions through the binding of the high affinity receptors EP. There are 4 isoforms of EP receptors with extracellular domains highly conserved, each coupling different intracellular transduction systems. Distribution of EP subtypes in the target tissues is therefore central to the pathways elicited by PGE2. <h3>Objectives</h3> The aim of this work was to study the regulation of EP1 and EP4 receptors in the inflamed synovial tissue. <h3>Methods</h3> We have studied different time periods in a rabbit model of antigen-induced arthritis: 24, 48 and 72 h (acute phase) and 1, 2 and 3 weeks (chronic phase). Knee synovial fluid (SF) volume and white cell count were measured. Total RNA was extracted from the synovial membranes and expression of EP1 and EP4 receptors was studied by RT-PCR techniques. A fraction of synovial tissue was fixed and embedded in paraffin for morphological studies. <h3>Results</h3> At the acute stages of the disease the animals depicted a synovial effusion that peaked at 48 h. The highest white cell infiltration was found at 24 h and was dominated by neuthophils; at 72 h neutrophils and mononuclear cells showed similar concentrations in the SF. Al longer time-periods only half of the cases showed a synovial effusion, of smaller proportion. The acute histopathologic lesions consisted of leakage of plasma elements with prominent neutrophil invasion. At 72 h lining hyperplasia developed and there was a switch to mononuclear cell infiltration at the subintima. At further stages, fibrotic changes and increases vascularisation were also found. EP1 receptor expression was up-regulated at every point of study, when compared to controls. EP1 expression increased in a time dependent fashion, peaking at 2 weeks (14-fold vs. control). On the other hand, healthy controls expressed moderate EP4 levels, which were dramatically reduced at the acute stage of the disease (90% reduction at 72 h). At the latest periods studied, there was a normalisation and even slight up-regulation of EP4 expression. <h3>Conclusion</h3> Our data may suggest that EP1 receptor mediates some of the PGE2 actions in experimental arthritis. This actions do not only include plasma leakage and activation of early inflammatory mediators, as EP1 up-regulation continues to increse when these typical features of acute arthritis are no longer evident. EP4 down-regulation at the early stages of the disease may suggest that this molecule do not participate in oedema and neutrophil activation induced by PGE2 in this experimental model. Restoring of the balance between PGE2 receptors in arthritis could be of help for the control of the inflammatory reaction.
Multi-Center Phase II Study of Oral Azacitidine (CC-486) Plus CHOP As Initial Treatment for Peripheral T-Cell Lymphoma (PTCL)
Authors: Jia Ruan, Alison J. Moskowitz, Neha Mehta-Shah, Lubomir Sokol, Zhengming Chen, Riyaad Rahim, Wei Song, Koen Van Besien, Steven M. Horwitz, Sarah C. Rutherford, Morton Coleman, Ari Melnick, Giorgio Inghirami, Leandro Cerchietti, John P. Leonard, Peter Martin
Journal: Blood (2020)
Inhibition of HIF-1a By PX-478 Normalizes Blood Vessels, Improves Drug Delivery and Suppresses Progression and Dissemination in Multiple Myeloma
Authors: Barbara Muz, Katherine Wasden, Kinan Alhallak, Amanda Jeske, Feda Azab, Jennifer Sun, Justin King, Daniel R. Kohnen, Ravi Vij, Abdel Kareem Azab
Journal: Blood (2020)
Apollo: Phase 3 Randomized Study of Subcutaneous Daratumumab Plus Pomalidomide and Dexamethasone (D-Pd) Versus Pomalidomide and Dexamethasone (Pd) Alone in Patients (Pts) with Relapsed/Refractory Multiple Myeloma (RRMM)
Authors: Meletios A. Dimopoulos, Evangelos Terpos, Mario Boccadoro, Sosana Delimpasi, Meral Beksac, Eirini Katodritou, Philippe Moreau, Luca Baldini, Argiris Symeonidis, Jelena Bila, Albert Oriol, Maria-Victoria Mateos, Hermann Einsele, Ioannis Orfanidis, Tahamtan Ahmadi, Jon Ukropec, Tobias Kampfenkel, Jordan Schecter, Yanping Qiu, Himal Amin, Jessica Vermeulen, Robin Carson, Pieter Sonneveld
Journal: Blood (2020)
Genetic Heterogeneity of KLF1, a Master Regulator of Erythropoiesis, Revealed an Autosomal Recessive Ψβ-Thalassemia and a Very Strong Promoter In Vivo
Authors: Laura Grech, Joseph Borg, Ruth Galdies, Carmen Attard, Christian A. Scerri, Sjaak Philipsen, Alexander E. Felice
Journal: Blood (2020)
Clinically extremely vulnerable adults should not leave home for work, says new advice
Authors: Zosia Kmietowicz
Journal: BMJ (2020)

extremely vulnerable adults should not leave home for work, says new advice Zosia KmietowiczPeople in England who are clinically extremely vulnerable will receive a letter this week urging them to stay at home as much as possible, including not going to work if they cannot work at home, and only to leave the house to exercise outdoors or to attend health appointments.
Preclinical and Translational Support for Clinical Development of Iberdomide in Combination with Proteasome Inhibitors: Mechanism of Synergy in Clinical Trial CC-220-MM-001
Authors: Michael Amatangelo, Chad Bjorklund, Jian Kang, Archana Mukhopadhyay, María Dolores Jiménez Nuñez, Lilly Wong, William Pierceall, Sagar Lonial, Niels W.C.J. van de Donk, Rakesh Popat, Sundar Jagannath, Jeffrey Zonder, Monique C. Minnema, Albert Oriol, Jeremy Larsen, Ashraf Z. Badros, Paula Rodriguez-Otero, Pieter Sonneveld, Tuong Vi Nguyen, Kevin Hong, April Sorrell, Anjan Thakurta
Journal: Blood (2020)
Abstract PO-030: Characterizing mechanisms for inhibiting metastasis in triple negative breast cancer
Authors: Dongbo Yang, Christopher Dann, Sebastian Pott, Marsha Rosner
Journal: Cancer Research (2020)

Abstract Tumor cell heterogeneity has been strongly implicated in metastatic progression of solid tumors such as breast cancer, leading to resistance and recurrence. We hypothesize that inhibiting metastasis will reduce tumor cell heterogeneity and thereby increase therapeutic sensitivity. To test this hypothesis, we expressed the metastasis suppressor Raf Kinase Inhibitory Protein (RKIP or PEBP1) in triple-negative breast cancer (TNBC) cells as a means of comparing the variation in gene expression between individual cells in metastatic versus non-metastatic tumors. Xenograft tumors with or without exogenous RKIP expression were dissociated into single cell suspensions. We removed mouse as well as dead cells, and the remaining cells were loaded onto a Fluidigm C1 high-throughput chip for separation and library preparation. For each condition we performed three independent experiments yielding a total of 1569 cells. We performed controls to ensure that differences were not due to batch effects, cell cycle stage or sample quality. Clustering of single cells across all samples indicated that gene expression profiles are similar, confirming reproducibility. Gene ontology analysis of differentially expressed genes between cells with and without RKIP overexpression reveals gene sets that are important in tumor cell transitions from metastatic to non-metastatic states. These data will allow us to specifically test whether metastatic tumors are more heterogeneous than non-metastatic tumors in TNBC. Citation Format: Dongbo Yang, Christopher Dann, Sebastian Pott, Marsha Rosner. Characterizing mechanisms for inhibiting metastasis in triple negative breast cancer [abstract]. In: Proceedings of the AACR Virtual Special Conference on Tumor Heterogeneity: From Single Cells to Clinical Impact; 2020 Sep 17-18. Philadelphia (PA): AACR; Cancer Res 2020;80(21 Suppl):Abstract nr PO-030.
Ibrutinib Maintenance (I-M) Following Intensive Induction in Mantle Cell Lymphoma (MCL): Efficacy, Safety and Changes in Minimal Residual Disease
Authors: Reem Karmali, Jeremy S Abramson, Deborah M. Stephens, Jeffrey A Barnes, Jason Kaplan, Jane N. Winter, Shuo Ma, Juehua Gao, Adam M Petrich, Ephraim Hochberg, Ronald Takvorian, Frank Kuhr, Valerie Nelson, Leo I. Gordon, Barbara Pro
Journal: Blood (2020)
Abstract 14613: Preferential Release of Nerve Growth Factor by the Left Atrial Appendage - A New Mechanism Underlying Autonomic Nerve Remodeling in Persistent Atrial Fibrillation?
Authors: Anna Pfenniger, Shin Yoo, Wenwei Zhang, Amy Burrell, David A Johnson, Georg Gussak, Lisa Wren, Mehul Gilani, Bradley P Knight, Rod S Passman, Rishi Arora
Journal: Circulation (2019)

Introduction: Persistent atrial fibrillation (peAF) is accompanied by left atrial sympathetic and parasympathetic hyperinnervation. Although nerve growth factor (NGF) is a key factor for cardiac au...