tbuckley/cabot-search huggingface dataset:
Association of Number of Indoor Tanning Salons With Neighborhoods With Higher Concentrations of Male-Male Partnered Households
Authors: Rebecca Chen, J. Aaron Hipp, Lily Morrison, Lisa Henriksen, Susan M. Swetter, Eleni Linos
Journal: JAMA Network Open (2019)

<h3>Importance</h3> Both indoor tanning and skin cancer are more common among sexual-minority men, defined as gay and bisexual men, than among heterosexual men. Convenient access to indoor tanning salons may influence use patterns. <h3>Objective</h3> To investigate whether indoor tanning salons are disproportionately located in areas with higher concentrations of gay men. <h3>Design, Setting, and Participants</h3> This cross-sectional study used geographic information systems to integrate census data and business location data obtained from ArcGIS and Google Maps for the 10 US cities with the largest lesbian, gay, bisexual, and transgender populations in 2010, ie, Los Angeles, California; Chicago, Illinois; San Francisco, California; Seattle, Washington; San Diego, California; Dallas, Texas; Phoenix, Arizona; Washington, DC; Portland, Oregon; and Denver, Colorado. The association of indoor tanning salon locations with proportions of gay men, using the concentration of male-male partnered households as a proxy measure for the latter, was examined. Data analysis was performed in October 2018. <h3>Exposures</h3> Census tracts with at least 1%, 5%, or 10% male-male partnered households, adjusting for median household income, percentage young women, and percentage non-Hispanic white residents. <h3>Main Outcomes and Measures</h3> Presence of 1 or more indoor tanning salons within census tracts. <h3>Results</h3> Across the 10 cities and 4091 census tracts in this study, there were 482 823 unmarried partnered households, of which 35 164 (7.3%) were male-male. The median (interquartile range) percentage of male-male partnered households per census tract was 0% (0%-10.6%). Odds of indoor tanning salon presence in areas with at least 10% male-male households were more than twice those of areas with less than 10% male-male households (odds ratio, 2.17; 95% CI, 1.59-2.97). When sensitivity analyses using a 1-mile euclidian buffer around each tanning salon were conducted, this association remained significant (odds ratio, 2.48; 95% CI, 2.14-2.88). After adjusting for median household income, percentage young women, and percentage non-Hispanic white residents, the odds of an indoor tanning salon being within 1 mile of a census tract with at least 10% male-male households remained twice that of census tracts with less than 10% male-male households (odds ratio, 2.00; 95% CI, 1.71-2.35). <h3>Conclusions and Relevance</h3> In this study, indoor tanning salons were more likely to be located near neighborhoods with higher concentrations of male-male partnered households, possibly contributing to the disproportionate use of indoor tanning by sexual-minority men.
Pulmonary tumour-draining vein exosomal lincRNA-p21 levels impacts non-small cell lung cancer prognosis
Authors: J.J. Castellano, A. Navarro, L. Molins, J. Canals, R. Marrades, N. Viñolas, J. Moises, M. Casadevall, Y. Li, B. Han, D. Martinez, J. Martin, A. Garisoain, C. Muñoz, J. Ramirez, M. Monzo
Journal: Annals of Oncology (2019)
The Role of the Microenvironment for CLL Proliferation and Survival: Gene Expression Profiling of Leukemic Cells Derived from Blood, Bone Marrow and Lymph Nodes Reveals the B-Cell Receptor and NF κB as Dominant Signaling Pathways
Authors: Yair Herishanu, Berengere Vire, Delong Liu, Federica Gibellini, Gerald E Marti, Therese White, Ndegwa Njuguna, Nalini Raghavachari, Poching Liu, Stefania Pittaluga, Peter J Munson, Wyndham H. Wilson, Adrian Wiestner
Journal: Blood (2008)
Lenvatinib (LEN) and pembrolizumab (PEMBRO) in advanced endometrial cancer (EC)
Authors: V. Makker, M.H. Taylor, C. Aghajanian, A. Oaknin, J. Mier, A.L. Cohn, M Romeo Marin, R Bratos Lorenzo, M.S. Brose, C. DiSimone, M.J. Messing, D.E. Stepan, C.E. Dutcus, J. Wu, E.V. Schmidt, R.J. Orlowski, P. Sachdev, R. Shumaker, A Casado Herraez
Journal: Annals of Oncology (2019)
Are immune checkpoint inhibitors a valid option for papillary renal cell carcinoma? Transcriptomic characterization of the immune infiltrate
Authors: M. De Vries-brilland, E. Menand, V. Seegers, J. Dauvé, C. Passot, J.-M. Marion, P. Chauvet, A. Morel, M. Gross-Goupil, A. Ravaud, E. Boughalem, B. Escudier, L. Albiges
Journal: Annals of Oncology (2019)
Comparison of intratumoral docetaxel exposure in cancer patients between nanoparticle entrapped docetaxel (CPC634) and conventional docetaxel (Cd): The CriTax study
Authors: R.A.G. Van Eerden, F. Atrafi, M.A.M. vanHylckama Vlieg, E. Oomen-de Hoop, P. de Bruijn, A. Moelker, M.P. Lolkema, C.J.F. Rijcken, R. Hanssen, F.A. Eskens, R.H.J. Mathijssen, S.L. Koolen
Journal: Annals of Oncology (2019)
Ebola treatments: trials stopped early for benefit tend to overestimate the effects of the intervention
Authors: David L Streiner
Journal: BMJ (2019)

A recent news item in The BMJ 1 reported that a trial of the antiviral vaccines mAB114 and REGN-EB3 was ended prematurely because it met early stopping criteria for effectiveness. This is encouraging for patients with Ebola, given its high mortality rate, and it is understandable that healthcare workers would want to get these drugs to patients as rapidly …
Obesity Independently Predicts Event Free Survival (EFS) in Adults with BCR-ABL-Negative Acute Lymphoblastic Leukemia (ALL). A Retrospective Analysis of Two GIMEMA Studies.
Authors: Anna Butturini, Marco Vignetti, Stefania Gubbiotti, Giovanna Meloni, Monica Recchia, Francesco Di Raimondo, Enrica Morra, Salvatore Palmieri, Francesco Fabbiano, Vincenzo Liso, Giovanni Pizzolo, Filippo Marmont, Nicola Cantore, Nicola Cascavilla, Mario Luppi, Andrea Camera, F. Ronco, F. Sora, Antonio Peta, Antonio Tabilio, Roberto Foa, Franco Mandelli
Journal: Blood (2005)
A systemic inflammation response index (SIRI) correlates with survival and could be a predictive factor for mFOLFIRINOX in metastatic pancreatic cancer (PC)
Authors: V.E. Pacheco-Barcia, R. Mondejar, T. France, J. Asselah, O. Donnay, G. Zogopoulos, N. Bouganim, K. Guo, E. Martin, T. Alcindor, R. Colomer Bosch
Journal: Annals of Oncology (2019)
Live biobank of patient-derived organoids from Thai colorectal cancer patients enables clinical outcome prediction
Authors: P. Tanjak, S. Rung in, O. Acharayothin, A. Mongkhonsupphawan, W. Chadbunchachai, A. Pongpaibul, W.V. Chalermwai, N. Kunapinun, D. Lohsiriwat, A. Trakarnsanga, V. Lohsiriwat, C. Iramaneerat, S. Prapasrivorakul, I. Chowchankit, K. Korphaisarn, S. Jirawatnotai, V. Chinswangwatanakul, W. Riansuwan, S. Sampattavanich
Journal: Annals of Oncology (2019)
Locally instructed CXCR4hi neutrophils trigger environment-driven allergic asthma through the release of neutrophil extracellular traps
Authors: Coraline Radermecker, Catherine Sabatel, Céline Vanwinge, Cecilia Ruscitti, Pauline Maréchal, Fabienne Perin, Joey Schyns, Natacha Rocks, Marie Toussaint, Didier Cataldo, Sebastian L Johnston, Fabrice Bureau, Thomas Marichal
Journal: Nature Immunology (2019)
Multiplex chromogenic Immunohistochemistry (IHC) for spatial analysis of checkpoint-positive tumour infiltrating lymphocytes (TILs)
Authors: S. Ely, G. Lee, L. Menard, J. Yan, P. Fischer, B. Kakrecha, D. Locke, P. Patah, K. Urbanska
Journal: Annals of Oncology (2019)
Precision medicine: Preliminary results from the initiative for molecular profiling and advanced cancer therapy 2 (IMPACT 2) study
Authors: A.M. Tsimberidou, D.S. Hong, S. Fu, D. Karp, S.A. Piha-Paul, M. Kies, V. Ravi, V. Subbiah, S. Patel, S.-M. Tu, F. Janku, J. Heymach, A. Johnson, J. Zhang, D.A. Berry, D. Vining, A. Futreal, V.A. Miller, F. Meric-Bernstam, L. Zhao
Journal: Annals of Oncology (2019)
Applicability of lung immune prognostic index (LIPI) to predict efficacy of first-line pembrolizumab in advanced non-small cell lung cancer (NSCLC)
Authors: X. Mielgo Rubio, A. Gomez Rueda, M. Antoñanzas, S. Falagan, J.A. Núñez, A.M. Sánchez Peña, I. Gómez-Barreda, E. Martinez Moreno, S. Cerezo Gonzalez, L. Cabezón Gutiérrez, J.M. Sanchez Torres, B.E. Jimenez Munarriz, R. Cervera, C. Pangua Mendez, A. Calles Blanco, A. Lopez Martin, R. López Castro, M.J. Sotelo Lezama, E. Pérez Fernández, P. Cruz
Journal: Annals of Oncology (2019)
Interleukin-6 as a predictive marker for early response to induction chemotherapy in acute myeloblastic leukaemia
Authors: S.M. Khallaf, Z.A.A. Abdelhafez, T.S. Ahmed, M.A.A. Abdou, S.M. Mansour, M.M. Salah Eldeen
Journal: Annals of Oncology (2019)
Can we improve patient selection for phase I clinical trials (phI1) based on immuno-oncology score prognostic index (VIO)?
Authors: I. Matos Garcia, C. Hierro, J. Martin-Liberal, C. VIAPLANA, A. Azaro, I. Brana, M. Vieito Villar, O. Saavedra, I. Gardeazabal, J. Ros, P. Prieto, R. Berché, E. Muñoz-Couselo, M. Oliveira, E. Elez Fernández, E. Felip, J. Carles, J. Tabernero, R. Dienstmann, E. Garralda
Journal: Annals of Oncology (2019)
Abstract #676: A novel daunorubicin derivative that overcomes MDR1- and MRP1-mediated drug resistance
Authors: Jeffrey Wang, Anh-Nhan Pham, Sravan Penchala, Ying Huang
Journal: Cancer Research (2009)

A major problem with anthracyclines, considered to be the most effective type of anticancer drugs, is the emergence of drug resistance. The well-characterized resistant mechanisms for anthracyclines include overexpression of efflux drug transporters such as multidrug resistance genes (MDR1, ABCB1, or P-glycoprotein) and multidrug resistance-associated proteins (MRP1, or ABCC1), which actively export drugs from the cells and thereby reduce intracellular drug accumulation. We hypothesize that direct modifications on the sugar moiety of anthracyclines would circumvent MDR1 and MRP1 efflux, increase drug concentration in cancer cells, and thus overcome transporter-mediated drug resistance. Several daunorubicin (DNR) derivatives were synthesized and characterized. Compared with the parent compound, one of the derivatives W10250 exhibited higher anticancer activity in both drug-sensitive leukemia cells HL-60 and K562 (MDR1(-) and MRP1(-)) and drug-resistant cells HL-60/ADR (MDR1(-)/MRP1(+)) and K562/DOX (MDR1(+)/MRP1(-)). The IC 50  for W10250 growth inhibition of K562 cells is 5-fold lower than that for DNR (0.02 vs. 0.10 µM), while the IC 50  for W10250 growth inhibition of K562/DOX cells is 250-fold lower than that for DNR (0.034 vs. 8.5 µM). The IC 50  for W10250 growth inhibition of HL-60 cells is 15-fold lower than that for DNR (0.001 vs. 0.015 µM), while the IC 50  for W10250 growth inhibition of HL-60/ADR cells is 3300-fold lower than that for DNR (0.002 vs. 6.6 µM). Drug uptake analysis using FACS assay demonstrated that W10250 abolished MDR1 and MRP1-mediated drug efflux and accumulated high intracellular concentration in the drug-resistance cells HL-60/ADR and K562/DOX. Inhibition of MDR1 and MRP1 by cyclosporine A and MK-571, respectively, supported the notion that this derivative is not a substrate for MDR1 and MRP1. DNR at 50 nM induced G2/M arrest in K562 cells through a well-documented topoisomerase II dependent mechanism, while 50 nM WL250 did not cause G2/M arrest but induced apoptosis, indicating a novel mechanism of action. These data suggest that specific sugar modification of anthracyclines abolish MDR1- and MRP1-mediated drug efflux, increase intracellular drug accumulation, and thus overcome both MDR1- and MRP1-mediated drug resistance in cancer therapy.   Citation Information:  In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 676.
Results of phase I clinical trial of high doses of seleno-l-methionine (SLM) in sequential combination with axitinib in previously treated and relapsed clear cell renal carcinoma (ccRCC) patients
Authors: Y. Zakharia, R. Garje, J. Brown, K. Nepple, A. Bellizzi, J. Bonner, D. Parr, J. Born, J. Sieren, J. Park, M. Milhem, Y. Rustum
Journal: Annals of Oncology (2019)
Exosomes from nicotine-stimulated macrophages accelerate atherosclerosis through miR-21-3p/PTEN-mediated VSMC migration and proliferation
Authors: Jumo Zhu, Bei Liu, Zhiyan Wang, Di Wang, Huaner Ni, Lili Zhang, Yi Wang
Journal: Theranostics (2019)

Rationale: During the development of atherosclerosis, macrophages secrete exosomes that regulate vascular smooth muscle cells (VSMCs); however, whether nicotine, a major constituent of cigarettes, can modulate this communication in the context of atherogenesis remains to be further studied. In this study, we hypothesized that nicotine induces macrophages to secrete atherogenic exosomes containing microRNAs (miRNAs) to mediate cell-to-cell crosstalk and encourage proatherogenic phenotypes of VSMCs. Methods: In an in vivo study, nicotine was administered subcutaneously to 8-week-old male ApoE-/- mice fed a high-fat diet (HFD) for 12 weeks. Oil red O and hematoxylin and eosin (HE) were used to stain atherosclerotic lesions. Lesion macrophages, VSMCs and exosomes were stained for CD68, α-smooth muscle actin (α-SMA) and CD9, and plaque exosomes were observed by transmission electron microscopy (TEM). Exosomes derived from control macrophages (M-Exos) and from nicotine-treated macrophages (NM-Exos) were isolated by ultracentrifugation, purified by sucrose density gradient centrifugation and characterized based on specific morphology and surface markers. The IVIS® Spectrum in vivo imaging system showed the biodistribution of NM-Exos and M-Exos in circulation. Chitosan hydrogel-incorporated exosomes were applied to simulate exosome secretion in situ. Scratch wound assay, transwell assay and EdU staining were conducted to assess the effects of NM-Exos on the migration and proliferation of mouse VSMCs. RNA-seq was performed to determine the miRNA profiles of M-Exos and NM-Exos. Quantitative real-time PCR (qRT-PCR) analysis was conducted to detect the expression levels of miRNAs and mRNAs. The roles of the candidate miRNA and its target gene were assessed using specific RNA inhibitors, siRNAs and miRNA mimics. Western blotting was used to detect candidate protein expression levels. A dual-luciferase reporting system was utilized to confirm the binding of a specific miRNA to its target gene. Results: Nicotine induced atherosclerotic lesion progression and resulted in plaque exosome retention in vivo. The biodistribution of NM-Exos showed that plaque-resident exosomes might be secreted in situ. VSMCs cocultured in vitro with nicotine-stimulated macrophages presented an increased capacity for migration and proliferation, which was exosome-dependent. In addition, isolated NM-Exos helped promote VSMC migration and proliferation. miRNA profiling showed that miR-21-3p was enriched in NM-Exos, and this miRNA was shown to play a key role in regulating NM-Exos-induced effects by directly targeting phosphatase and tension homologue (PTEN). Conclusion: Exosomal miR-21-3p from nicotine-treated macrophages may accelerate the development of atherosclerosis by increasing VSMC migration and proliferation through its target PTEN.
Prevalence of venous thromboembolism based on intensive screening for patients with advanced solid tumor in prospective observational study
Authors: S. Omori, H. Kenmotsu, A. Notsu, K. Mori, T. Tsushima, Y. Satake, Y. Miki, M. Abe, M. Ogiku, T. Nakamura, M. Takagi, H. Ochiai, H. Yasui, T. Takahashi
Journal: Annals of Oncology (2019)
THE PROBABILITY OF FINDING SIGNIFICANT OBSTRUCTIVE CORONARY ARTERY DISEASE BY CORONARY CT ANGIOGRAPHY IN SMOKERS VERSUS NONSMOKERS BELOW AGE 60 IN A LARGE, MULTI-PHYSICIAN OUTPATIENT CARDIOLOGY PRIVATE PRACTICE
Authors: Yesh Dhruva, Ronak Agarwal, Rajiv Agarwal
Journal: Journal of the American College of Cardiology (2019)
Prognostic factors for non-small cell lung cancer patients with driver mutation negative and brain metastases (HOT 1701)
Authors: Y. Ohhara, T. Kojima, O. Honjo, N. Yamada, T. Sato, M. Kunisaki, K. Takamura, T. Takashina, N. Sukoh, H. Tanaka, Y. Kawai, Y. Fujita, F. Sugaya, F. Hommura, T. Harada, H. Ryoichi, I. Kinoshita, T. Amano, S. Oizumi, H.D. Akita
Journal: Annals of Oncology (2019)
A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell–Intrinsic Transcriptional MSI Traits
Authors: Simona Corso, Claudio Isella, Sara E. Bellomo, Maria Apicella, Stefania Durando, Cristina Migliore, Stefano Ughetto, Laura D’Errico, Silvia Menegon, Daniel Moya-Rull, Marilisa Cargnelutti, Tânia Capelôa, Daniela Conticelli, Jessica Giordano, Tiziana Venesio, Antonella Balsamo, Caterina Marchiò, Maurizio Degiuli, Rossella Reddavid, Uberto Fumagalli, Stefano De Pascale, Giovanni Sgroi, Emanuele Rausa, Gian Luca Baiocchi, Sarah Molfino, Filippo Pietrantonio, Federica Morano, Salvatore Siena, Andrea Sartore-Bianchi, Maria Bencivenga, Valentina Mengardo, Riccardo Rosati, Daniele Marrelli, Paolo Morgagni, Stefano Rausei, Giovanni Pallabazzer, Michele De Simone, Dario Ribero, Silvia Marsoni, Antonino Sottile, Enzo Medico, Paola Cassoni, Anna Sapino, Eirini Pectasides, Aaron R. Thorner, Anwesha Nag, Samantha D. Drinan, Bruce M. Wollison, Adam J. Bass, Silvia Giordano
Journal: Cancer Research (2019)

Abstract Gastric cancer is the world's third leading cause of cancer mortality. In spite of significant therapeutic improvements, the clinical outcome for patients with advanced gastric cancer is poor; thus, the identification and validation of novel targets is extremely important from a clinical point of view. We generated a wide, multilevel platform of gastric cancer models, comprising 100 patient-derived xenografts (PDX), primary cell lines, and organoids. Samples were classified according to their histology, microsatellite stability, Epstein–Barr virus status, and molecular profile. This PDX platform is the widest in an academic institution, and it includes all the gastric cancer histologic and molecular types identified by The Cancer Genome Atlas. PDX histopathologic features were consistent with those of patients' primary tumors and were maintained throughout passages in mice. Factors modulating grafting rate were histology, TNM stage, copy number gain of tyrosine kinases/KRAS genes, and microsatellite stability status. PDX and PDX-derived cells/organoids demonstrated potential usefulness to study targeted therapy response. Finally, PDX transcriptomic analysis identified a cancer cell–intrinsic microsatellite instability (MSI) signature, which was efficiently exported to gastric cancer, allowing the identification, among microsatellite stable (MSS) patients, of a subset of MSI-like tumors with common molecular aspects and significant better prognosis. In conclusion, we generated a wide gastric cancer PDX platform, whose exploitation will help identify and validate novel “druggable” targets and optimize therapeutic strategies. Moreover, transcriptomic analysis of gastric cancer PDXs allowed the identification of a cancer cell–intrinsic MSI signature, recognizing a subset of MSS patients with MSI transcriptional traits, endowed with better prognosis. Significance: This study reports a multilevel platform of gastric cancer PDXs and identifies a MSI gastric signature that could contribute to the advancement of precision medicine in gastric cancer.
Clonal Hematopoiesis and Atherosclerosis
Authors: Bruno Cassinat, Claire Harrison, Jean-Jacques Kiladjian
Journal: New England Journal of Medicine (2017)

Jaiswal et al. report the results of four case–control studies that confirm a near doubling in the risk of coronary heart disease in patients with CHIP,1 a finding that was first reported in the Journal in 2014.2 The authors postulate that two mechanisms may be involved: the promotion of inflammatory responses, as supported in a study involving Tet2 knockout mice, and an increase in the number of myeloid cells, a finding that appears to be more relevant for patients with JAK2 mutations, which confer a much larger risk than the more common DNMT3A, TET2, and ASXL1 mutations, in which blood counts remain normal. However, the authors do not provide data relating to red-cell distribution width, which is the only blood-cell index that has been shown to have a significant association with CHIP2 and which has been associated with an unexplained increase in all-cause mortality in an aging population. 3,4 In understanding how CHIP promotes atherosclerosis, it is important to explore the causal relationship between clonal hematopoiesis and red-cell anisocytosis to determine whether these are independent or associated risk factors for cardiovascular disease.
Specific macrophage populations promote both cardiac scar deposition and subsequent resolution in adult zebrafish
Authors: Laura Bevan, Zhi Wei Lim, Byrappa Venkatesh, Paul R Riley, Paul Martin, Rebecca J Richardson
Journal: Cardiovascular Research (2019)

A robust inflammatory response to tissue injury is a necessary part of the repair process but the deposition of scar tissue is a direct downstream consequence of this response in many tissues including the heart. Adult zebrafish not only possess the capacity to regenerate lost cardiomyocytes but also to remodel and resolve an extracellular scar within tissues such as the heart, but this scar resolution process remains poorly understood. This study aims to characterize the scarring and inflammatory responses to cardiac damage in adult zebrafish in full and investigate the role of different inflammatory subsets specifically in scarring and scar removal.Using stable transgenic lines, whole organ imaging and genetic and pharmacological interventions, we demonstrate that multiple inflammatory cell lineages respond to cardiac injury in adult zebrafish. In particular, macrophage subsets (tnfα+ and tnfα-) play prominent roles with manipulation of different phenotypes suggesting that pro-inflammatory (tnfα+) macrophages promote scar deposition following cardiac injury whereas tnfα- macrophages facilitate scar removal during regeneration. Detailed analysis of these specific macrophage subsets reveals crucial roles for Csf1ra in promoting pro-inflammatory macrophage-mediated scar deposition. Additionally, the multifunctional cytokine Osteopontin (Opn) (spp1) is important for initial scar deposition but also for resolution of the inflammatory response and in late-stage ventricular collagen remodelling.This study demonstrates the importance of a correctly balanced inflammatory response to facilitate scar deposition during repair but also to allow subsequent scar resolution, and full cardiac regeneration, to occur. We have identified Opn as having both pro-fibrotic but also potentially pro-regenerative roles in the adult zebrafish heart, driving Collagen deposition but also controlling inflammatory cell resolution.
Sensitization of cholangiocarcinoma to chemotherapy by SOX17- induced down-regulation of drug export pumps ABCC3 and AGCG2
Authors: E. Lozano, O. Briz, M. Asensio, L. Perez-Silva, M. Monte, M. Perez, E. Herraez, M. Romero, M. Serrano, R. Macias, L. Bujanda, J. Banales, J. Marin
Journal: Journal of Hepatology (2018)
Incidence of vascular thromboembolism events in cancer patients receiving immunotherapy: A single institution experience
Authors: L. Gutiérrez Sainz, V. Martínez-Marin, D. Viñal Lozano, D. Martínez Pérez, J. Pedregosa Barbas, J.A. García Cuesta, J. Villamayor Sánchez, P. Zamora, A. Pinto Marin, B. Castelo, A. Redondo, A. Gallego Martínez, P. Cruz, O. Higuera Gomez, A. Custodio, D. Sánchez Cabrero, J. De Castro Carpeno, E. Espinosa, J. Feliu Batlle
Journal: Annals of Oncology (2019)