AB0913 To determine the association between plaque and non plaque psoriasis with their joint manifestation in psoriatic arthritis patient – a single centre experience in malaysia
Authors: C.R. Ng, L. Selvarajah, Y.L. Loh
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Psoriatic arthritis (PsA) which is a member of the spondyloarthritides includes spinal and peripheral joint involvement. It affects women and men equally. The clinical patterns of PsA were classified into 5 groups according to Moll and Wright..<sup>1</sup> Psoriasis is a common chronic inflammatory skin disease and chronic plaque psoriasis is the commonest form. <h3>Objectives</h3> To study the relationship between plaque and non-plaque psoriasis with their joint manifestation and to describe the demographic characteristics of PsA patients. <h3>Methods</h3> This was a restrospective study. The electronic medical records of all PsA patients under rheumatology clinic Hospital Sultan Ismail followed up from 1/1/2009 to 31/12/2017 were reviewed. Data on demography, type of skin disease, joint manifestation, past medical history, fasting serum lipid and body mass index were obtained and analysed. <h3>Results</h3> We identified 163 patients, 84 were male patients with male to female ratio of 1.06. The Malays (84/163) were the majority being affected, followed by the Chinese (46/163), Indians (30/163) and others (3/163). The patients were divided into plaque psoriasis (140/163) and non-plaque psoriasis (23/163). The commonest joint involvement in the study was peripheral joint involvement (121/163), axial involvement (22/163) and both axial and peripheral joint involvement (20/163). The peripheral joint involvement was categorised as polyarthritis (67/121), followed by oligoarthritis (47/121), distal interphalangeal arthritis (4/121) and arthritis mutilans (3/121). In the study, we divided the patients into plaque psoriasis [peripheral joint involvement (102/140); axial involvement (16/140); both (18/140)] and non-plaque psoriasis [peripheral joint involvement (15/23); axial involvement (6/23); both (2/23)] and analysed the results by using the SPSS logistic regression. It showed no significant association between type of skin psoriasis with its joint manifestation. (p&gt;0.05). Amongst the 163 patients, 68/163 (42%) had hypertension, 50/163 (31%) had diabetes mellitus, 32/163 (20%) had hypercholesterolemia, 12/163 have ischaemic heart disease, 1 patient had congestive heart disease, 3 had breast cancer, 1 had hepatocellular carcinoma and 2 have chronic kidney disease and cerebral vascular disease respectively. The fasting serum lipid (FSL) was taken for 140 of them (23 patients no data available) and it was noted in 64/140 (without background history of hypercholesterolemia was noted to have FSL≥5.18 mmol/L). 37/64 have borderline high total cholesterol (5.18 mmol/L –&lt;6.2 mmol/L) and 27/64 have high total cholesterol (≥6.2 mmol/L) according to ATP iii cholesterol classification..<sup>2</sup> 43% (61/142 patients) had body mass index in the overweight group, 29% (41/142 patients) in the obese group and 25% (36/142 patients) in normal group according to WHO classification.<sup>3</sup> <h3>Conclusions</h3> There was no association between types of skin psoriasis with their joint manifestation. There was a significant number of patients who had deranged fasting serum lipid and majority of them have BMI in the overweight and obese group. <h3>References</h3> [1] Psoriatic arthritis. Wright V, Moll JM. Bull Rheum Dis. 1971;21(5):627. [2] ATP iii report on high blood cholesterol [3] WHO Classification of Body Mass Index, 2004. <h3>Disclosure of Interest</h3> None declared