tbuckley/cabot-search huggingface dataset:
Impact of older age on the locoregional and distant breast cancer recurrence risk: A large population-based study
Authors: A.Z. de Boer, H.C. van der Hulst, W. van der Plas-Krijgsman, N.A. de Glas, P.J. Marang-van de Mheen, S. Siesling, G.-J. Liefers, E. Bastiaannet, J.E.A. Portielje
Journal: Annals of Oncology (2019)

Background: Although previous studies have suggested a higher risk of breast cancer recurrence with increasing age, older patients with early stage breast cancer generally receive less extensive treatment. The aim of this study was to evaluate the impact of older age on risk of locoregional and distant recurrence among patients aged 70 years or older in a large population based cohort. Methods: Patients aged 70 years and older who were diagnosed with early stage breast cancer between 2003 and 2009 and underwent surgery were selected from the Netherlands Cancer Registry. Cumulative incidences of locoregional and distant recurrence according to age categories were calculated using the Cumulative Incidence Competing Risks (CIRC) method. The Fine and Gray model was used to estimate the effect of age on recurrence which was expressed as subdistribution hazard ratio (sHR). A two-step multivariable analysis was performed, the first multivariable model adjusted for patient and tumor characteristics and the second model, the full model, additionally adjusted for treatment characteristics. Results: Overall, 19748 patients were included. During follow-up, 832 of 7799 patients (10.7%) aged 70-74 years, 707 of 4344 patients (16.3%) aged 75-79 years and 927 of 6322 patients (14.7%) aged ≥80 years had a locoregional or distant recurrence. In univariate analysis, age 75-79 years and ≥80 years were associated with a higher risk of locoregional and distant recurrence compared to the reference age group of 70-74 years. After adjustment in the full multivariable model, the risk of distant recurrence remained significantly higher for patients aged 75-79 (sHR: 1.25, 95% CI 1.11-1.41, p = 0.001), but not for patients aged ≥80 years (sHR: 1.04, 95% CI 0.93-1.18, p = 0.483). For locoregional recurrence risk, no significant association with age was found in the multivariable analysis. Conclusions: In this large population based study, patients aged 75-79 years were at increased risk of distant recurrence compared to patients aged 70-74 years. Possible explanations can be suboptimal treatment selection and different treatment response in older patients compared to younger patients. Legal entity responsible for the study: Leiden University Medical Center. Funding: ZonMw. Disclosure: All authors have declared no conflicts of interest.
PREDICTIVE MODEL TO DETERMINE THE NEED OF REPEATING ERCP AFTER ENDOSCOPIC TREATMENT OF BILIARY LEAKS
Authors: JC Silva, J Rodrigues, R Pinho, L Proença, C Fernandes, M Sousa, AC Gomes, J Carvalho
Journal: Endoscopy (2019)

Endoscopic retrograde cholangiopancreatography (ERCP) is the first-line procedure to iatrogenic biliary leaks approach. In patients who have undergone biliary stenting, the timing and optimal method of stent removal (ERCP/esophagogastroduodenoscopy) is controversial. The present study aimed to evaluate ERCP efficacy in biliary leaks treatment and identify patients in whom repetition of ERCP may be unnecessary.
GASTRIC SUBMUCOSAL TUMORS: MOLECULAR MARKERS ASSESSMENT ON EUS-FNA SAMPLES
Authors: IF Cherciu, IM Cazacu, ET Ivan, A Saftoiu
Journal: Endoscopy (2019)

Gastric submucosal lessions might have a benign or malign character. In order to determine the diagnosis of gastric submucosal tumors an important role is played by the endoscopic ultrasound (EUS) assessment. Solely EUS can not help to distinguish specific aspects of the pathology, for instance the degree of malignancy. EUS-guided fine-needle aspiration (EUS-FNA) is more useful in clarifing this distinctions through the use of immunohistochemical staining or genotype analysis. The aim of our study was to conduct a systematic review of literature assessing different molecular markers performed on gastric EUS-FNA samples in order to outline the most widely investigated diagnostic markers which might be further used in the early management of small gastric submucosal tumors. The biomarkers tested on a limited EUS-FNA sample would not only aid the diagnosis but it would allow furthermore a better patients stratification for therapies, hence an immediate clinical impact.
A Systematic Review of <i>In Vitro</i> and <i>In Vivo</i> Radio Frequency Exposure Methods
Authors: Jared W. Hansen, Ellen M. Swartz, Jerika D. Cleveland, Sajid M. Asif, Benjamin Brooks, Benjamin D. Braaten, Daniel L. Ewert
Journal: IEEE Reviews in Biomedical Engineering (2019)

Recently, interest in the effects of radio frequency (RF) on biological systems has increased and is partially due to the advancements and increased implementations of RF into technology. As research in this area has progressed, the reliability and reproducibility of the experiments has not crossed multidisciplinary boundaries. Therefore, as researchers, it is imperative to understand the various exposure systems available as well as the aspects, both electromagnetic and biological, needed to produce a sound exposure experiment. This systematic review examines common RF exposure methods for both in vitro and in vivo studies. For in vitro studies, possible biological limitations are emphasized. The validity of the examined methods, for both in vitro and in vivo, are analyzed by considering the advantages and disadvantages of each. This review offers guidance for researchers to assist in the development of an RF exposure experiment that crosses current multidisciplinary boundaries.
Significant limitations of a systematic review and meta‐analysis of interventions to promote skin self‐examination: reply from the authors
Authors: S.J. Ersser, J. Dyson, A. Muinonen‐Martin
Journal: British Journal of Dermatology (2019)

Linked articles: Coups. Br J Dermatol 2019; 181:640–641. Ersser et al. Br J Dermatol 2019; 180:1339–1347.
Circular RNA ACVR2A suppresses bladder cancer cells proliferation and metastasis through miR-626/EYA4 axis
Authors: Wei Dong, Junming Bi, Hongwei Liu, Dong Yan, Qingqing He, Qianghua Zhou, Qiong Wang, Ruihui Xie, Yinjie Su, Meihua Yang, Tianxin Lin, Jian Huang
Journal: Molecular Cancer (2019)

Circular RNAs (circRNAs) have been considered to mediate occurrence and development of human cancers, generally acting as microRNA (miRNA) sponges to regulate downstream genes expression. However, the aberrant expression profile and dysfunction of circRNAs in human bladder cancer remain to be investigated. The present study aims to elucidate the potential role and molecular mechanism of circACVR2A in regulating the proliferation and metastasis of bladder cancer. circACVR2A (hsa_circ_0001073) was identified by RNA-sequencing and validated by quantitative real-time polymerase chain reaction and agarose gel electrophoresis. The role of circACVR2A in bladder cancer was assessed both in vitro and in vivo. Biotin-coupled probe pull down assay, biotin-coupled microRNA capture, dual-luciferase reporter assay, and fluorescence in situ hybridization were conducted to evaluate the interaction between circACVR2A and microRNAs. The expression of circACVR2A was lower in bladder cancer tissues and cell lines. The down-regulation of circACVR2A was positively correlated with aggressive clinicopathological characteristics, and circACVR2A served as an independent risk factor for overall survival in bladder cancer patients after cystectomy. Our in vivo and in vitro data indicated that circACVR2A suppressed the proliferation, migration and invasion of bladder cancer cells. Mechanistically, we found that circACVR2A could directly interact with miR-626 and act as a miRNA sponge to regulate EYA4 expression. circACVR2A functions as a tumor suppressor to inhibit bladder cancer cell proliferation and metastasis through miR-626/EYA4 axis, suggesting that circACVR2A is a potential prognostic biomarker and therapeutic target for bladder cancer.
RISK FACTORS OF DYSPLASIA AND ADENOCARCINOMA IN BARRETT'S ESOPHAGUS
Authors: R Kallel, M Sabbah, D Trad, A Ouakaa, N Bibani, H Elloumi, D Gargouri
Journal: Endoscopy (2019)

Barrett's esophagus (BE) is a rare lesion that can progress to adenocarcinoma of the lower esophagus Endoscopic and histological monitoring is necessary to detect these lesions early and to propose appropriate management.
Place de l'échografie abdominale dans le bilan initial de la maladie coeliaque
Authors: H Kchir, R Tlili, D Issaoui, A hassine, H Chaabouni, N Maamouri
Journal: Endoscopy (2019)

La maladie coeliaque (MC) est une maladie chronique de l'intestin due à une intolérance au gluten, dont l'atteinte hépatique est l'une de ses plus fréquentes atteintes extra intestinales. Le but de notre étude était d'évaluer l'utilité de l'échografie abdominale (EA) initiale dans la détection des anomalies liées à la MC.
REFRACTORY GAVE TREATED WITH RADIOFREQUENCY ABLATION BY THROUGH-THE-SCOPE CATHETER: THREE CASES OF COMPLETE RESPONSE
Authors: M Maida, G Morreale, G Scarpulla, M Manganaro, S Garufi, S Camilleri
Journal: Endoscopy (2019)

Gastric antral vascular ectasia (GAVE), or watermelon stomach, is an uncommon cause of upper gastrointestinal bleeding. One emerging and promising endoscopic treatment for GAVE is radiofrequency ablation (RFA) with focal catheters (e.g.HALO90and HALOULTRA). We present three cases of refractory GAVE treated with radiofrequency ablation with the smaller and more handling through-the-scope (TTS) catheter, with long-term response.
Planning for Retiring From Operating
Authors: Julie Ann Freischlag
Journal: JAMA Surgery (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Etude de concordance intra- et inter-observateur de la mesure du volume tumoral pancréatique par échoendoscopie: application à un protocole de thérapie génique du cancer du pancréas (Etude THERKAPPA)
Authors: L Buscail, A Culetto, FZ Mokrane, B Napoléon, O Meyrignac, B Molinier, C Canivet, E Berard, B Bournet
Journal: Endoscopy (2019)

Nous avons mené un essai de phase 1 de thérapie génique appliquée au cancer du pancréas (Essai Thergap-1) par injection intra-tumorale directe sous échoendoscopie (EE) d'un produit de thérapie génique CYL-02 visant à induire une chimio sensibilisation par la gemcitabine administrée dans les suites de l'injection selon l'AMM (Mol. Therapy 2015;23:779 – 789). L'évaluation de l'effet anti-tumoral a été faite au cours de ce protocole au moyen de la TDM qui seule est reconnue pour apprécier les critères RECIST. Toutefois: a) l'évaluation TDM des adénocarcinomes pancréatiques peut être mise en défaut compte tenu du caractère infiltrant de certaines tumeurs; b) à l'heure du développement des traitements locaux dirigés sous EE cette dernière pourrait être intégrée dans les examens d'évaluation du volume tumoral lors des futurs essais pilotes de traitements innovants des tumeurs pancréatiques. Le but de l'étude THERKAPPA était d'évaluer la concordance intra- et inter-observateur de la mesure sous EE du volume des tumeurs primaires pancréatiques à partir de l'essai Thergap-1.
Technique optimale de la résection endoscopique des polypes diminutifs
Authors: F Aissaoui, M Zakhama, S Ben Amor, I Jemni, A Guediche, W Bouhlel, W Ben Mansour, HL Mohamed, BC Nabil, L Safer
Journal: Endoscopy (2019)

Les sociétés savantes recommandent la polypectomie à l'anse comme technique optimale de résection des polypes sessile et plans de taille ≤5 mm (micro-polypes). Par rapport aux autres techniques, elle assure un moindre risque de complications et permet des taux élevés de résection complète et de tissus adéquats pour l'examen histologique.
Outcomes of Hematopoietic Stem Cell Transplant in Older Patients with Myelodysplastic Syndrome and Co-Existing Myelofibrosis: A Single Center Experience and Review of the Literature
Authors: Abhijit B Saste, Philip Kuriakose, Nalini Janakiraman, Edward Peres, Shatha Y. Farhan
Journal: Blood (2016)
Evolving Issues in the Treatment of Depression
Authors: Ole Köhler-Forsberg, Cristina Cusin, Andrew A. Nierenberg
Journal: JAMA (2019)

This Viewpoint discusses recent evidence documenting benefits of nonpharmacological and drug therapies for major depressive disorder including exercise, Mediterranean diet and structured dietary support, ketamine and esketamine, anti-inflammatory drugs, brexanolone, and psilocybin.
Abstract 14697: Novel Assays for Quantification of Lipoprotein-Associated (PCSK9-apoB, PCSK9-Lp(a)) Proprotein Covertase Subtilisin/Kexin Type 9 (PCKS9)
Authors: Calvin Yeang, Yun-Seok Choi, Sang-Rok Lee, Monica L Bertoia, Eric B Rimm, Xiaohong Yang, Joseph L Witztum, Sotirios Tsimikas
Journal: Circulation (2015)

Background: PCSK9 is a major regulator of plasma LDL-C. Monoclonal antibodies to PCSK9 lower LDL-C by 45-65% and Lp(a) by 9-38%. The canonical function of PCSK9 is binding of LDL-receptor (LDLR) via its extracellular EGF-A domain, and subsequently mediating LDLR degradation. However, PCSK9 also weakly associates with plasma lipoproteins, with 20-40% of total plasma PCSK9 found on LDL. However, most LDL particles do not contain PCSK9. Whether PCSK9 also associates with other lipoproteins such as Lp(a) are not well described. Methods: Sensitive and quantitative sandwich-based ELISA assays were developed to measure PCSK9 associated plasma lipoproteins in both mouse and human plasma. For human plasma, commercial rabbit polyclonal antibodies binding to the C-terminal region of PCSK9 (Abgent, ThermoFisher) or REGN727 human monoclonal antibody were bound to microtiter well plates. Plasma was added and monoclonal antibodies MB47 and LPA4, binding to apoB-100 and apo(a) respectively, were used to detect PCSK9-apoB-100 and PCSK9-Lp(a) complexes with a chemiluminescent ELISA. For mouse assays, REGN727 was used as the capture antibody as it detects mouse PCSK9 and monoclonal antibody LF3 was used to detect mouse apoB. Results: PCSK9-apoB and PCSK9-Lp(a) complexes could be detected in both human plasma and in various mouse models expressing apo(a) or Lp(a). The signal to noise ratio was ~20 fold in various clinical samples, including in healthy subjects and in patients with cardiovascular disease. In 536 clinical samples from the Health Professional Follow-Up Study, PCSK9-Lp(a) correlated strongly with Lp(a) (r=0.59, p&lt;0.001, age-adjusted) but not other lipid variables. PCSK9-apoB correlated weakly with PCSK9-Lp(a) (r=0.30, p&lt;0.001, age-adjusted) and LDL-C (r=0.22, p&lt;0.001, age-adjusted). These associations were virtually the same in 526 women in the Nurses’ Health Study. Conclusions: Novel ELISAs were generated to quantitate lipoprotein-associated PCSK9 in transgenic mouse and human plasma, including on apoB and Lp(a). Changes in PCSK9-Lp(a) complexes may provide insights into the Lp(a)-lowering effect of PCSK9 antibodies. Whether these assays will predict CVD outcomes waits to be determined in PCSK9 antibody and epidemiological studies.
A RETROSPECTIVE ANALYSIS TO ASSESS THE IMPORTANCE OF DOING A BILIARY SPHINCTEROTOMY TO INCREASE AND SIMPLIFY CANNULATION SUCCESS RATE OF THE MAIN PANCREATIC DUCT
Authors: P Desai, M Kabrawala, S Nandwani, R Mehta, C Patel, P Kalra, R Prajapati, N Patel
Journal: Endoscopy (2019)

MPD cannulation is the prime requisite for any pancreatic endotherapy during an ERCP. Very few techniques are described for selective pancreatic duct cannulation. When doing primary pancreatic therapy in cases where MPD cannulation is difficult, if we could get the wire into the CBD first, then doing a wide biliary sphincterotomy is shown to increase the success of cannulation of the MPD without using any more sophisticated techniques.
EVALUATING DIGITAL SINGLE-OPERATOR-CHOLANGIOSCOPY FOR THE TREATMENT OF DIFFICULT BILIARY STONES: A RETROSPECTIVE MULTICENTER TRIAL
Authors: A Bokemeyer, F Lenze, D Lang, C Gerges, D Bettenworth, H Schmidt, H Neuhaus, H Ullerich, T Beyna
Journal: Endoscopy (2019)

In patients with difficult biliary stones, standard endoscopic treatment might fail and recently introduced digital single-operator cholangioscopes (SOCs), equipped with an improved imaging quality, might be used as a rescue treatment approach.
NARROW BAND IMAGING CHARACTERISTICS OF POLYPOID GASTRIC LESIONS: A SINGLE CENTER PROSPECTIVE STUDY
Authors: G Esposito, S Angeletti, M Cazzato, G Galli, L Conti, E Lahner, E Di Giulio, B Annibale
Journal: Endoscopy (2019)

Forty pts (F 55%; median age 63 (36 – 85)yrs) presenting at least one GPL were investigated. Gastroscopies were performed by two experienced endoscopists. GPL images were recorded during gastroscopies and GPL were removed for histological examinations. Both endoscopists independently reviewed digital images in a blinded manner and registered endoscopic NBI appearances on a specific check-list previously elaborated. Endoscopists evaluated the mucosal and vascular pattern and could further indicate other features. Disagreement was resolved by discussion. GPL were then categorized in three different groups (HP, adenomas and T1-GC) using the histological exam as gold standard.
RISK OF RECURRENCE AFTER ENDOSCOPIC SUBMUCOSAL DISSECTION FOR ADVANCED COLORECTAL NEOPLASIA: SINGLE CENTER EXPERIENCE
Authors: H Kim, BM Ko, HJ Goong, MS Lee
Journal: Endoscopy (2019)

Endoscopic submucosal dissection (ESD) is known as a curative treatment option for colorectal tumor. A limited number of studies have evaluated the recurrence rates of ESD for advanced colorectal neoplasia. The aim of this study was to evaluate the recurrence rates and risk factors of recurrence after ESD for advanced colorectal neoplasia.
Acute heart failure congestion and perfusion status – impact of the clinical classification on in‐hospital and long‐term outcomes; insights from the ESC‐EORP‐HFA Heart Failure Long‐Term Registry
Authors: Ovidiu Chioncel, Alexandre Mebazaa, Aldo P. Maggioni, Veli‐Pekka Harjola, Giuseppe Rosano, Cecile Laroche, Massimo F. Piepoli, Maria G. Crespo‐Leiro, Mitja Lainscak, Piotr Ponikowski, Gerasimos Filippatos, Frank Ruschitzka, Petar Seferovic, Andrew J.S. Coats, Lars H. Lund
Journal: European Journal of Heart Failure (2019)
Sex Differences in Presentation and Outcome After an Acute Transient or Minor Neurologic Event
Authors: Amy Y. X. Yu, Andrew M. Penn, Mary L. Lesperance, Nicole S. Croteau, Robert F. Balshaw, Kristine Votova, Maximilian B. Bibok, Melanie Penn, Viera Saly, Janka Hegedus, Charlotte Zerna, Evgenia Klourfeld, Lisa Bilston, Zachary M. Hong, Shelagh B. Coutts
Journal: JAMA Neurology (2019)

Sex differences have been described in the presentation, care, and outcomes among people with acute ischemic strokes, but these differences are less understood for minor ischemic cerebrovascular events. The present study hypothesized that, compared with men, women are more likely to report nonfocal symptoms and to receive a stroke mimic diagnosis.To evaluate sex differences in the symptoms, diagnoses, and outcomes of patients with acute transient or minor neurologic events.This prospective cohort study of patients with minor ischemic cerebrovascular events or stroke mimics enrolled at multicenter academic emergency departments in Canada between December 2013 and March 2017 and followed up for 90 days is a substudy of SpecTRA (Spectrometry for Transient Ischemic Attack Rapid Assessment). In total, 1729 consecutive consenting patients with acute transient or minor neurologic symptoms were referred for neurologic evaluation; 66 patients were excluded for protocol violation (n = 46) or diagnosis of transient global amnesia (n = 20).The main exposure was female or male sex.The main outcome was the clinical diagnosis (cerebral ischemia vs stroke mimic). Secondary outcomes were 90-day stroke recurrence and 90-day composite outcome of stroke, myocardial infarction, or death. The association between presenting symptoms (focal vs nonfocal) and clinical diagnosis was also assessed. Research hypotheses were formulated after data collection.Of 1648 patients included, 770 (46.7%) were women, the median (interquartile range) age was 70 (59-80) years, 1509 patients (91.6%) underwent brain magnetic resonance imaging, and 1582 patients (96.0%) completed the 90-day follow-up. Women (522 of 770 [67.8%]) were less likely than men (674 of 878 [76.8%]) to receive a diagnosis of cerebral ischemia (adjusted risk ratio [aRR], 0.88; 95% CI, 0.82-0.95), but the 90-day stroke recurrence outcome (aRR, 0.90; 95% CI, 0.48-1.66) and 90-day composite outcome (aRR, 0.86; 95% CI, 0.54-1.32) were similar for men and women. No significant sex differences were found for presenting symptoms. Compared with patients with no focal neurologic symptoms, those with focal and nonfocal symptoms were more likely to receive a diagnosis of cerebral ischemia (aRR, 1.28; 95% CI, 1.15-1.39), but the risk was highest among patients with focal symptoms only (aRR, 1.45; 95% CI, 1.34-1.53). Sex did not modify these associations.The results of the present study suggest that, despite similar presenting symptoms among men and women, women may be more likely to receive a diagnosis of stroke mimic, but they may not have a lower risk than men of subsequent vascular events, indicating potentially missed opportunities for prevention of vascular events among women.
Sleeping In Doesn’t Mitigate Metabolic Changes Linked to Sleep Deficit
Authors: Rita Rubin
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Arterial subtraction images of gadoxetate-enhanced MRI improve diagnosis of early-stage hepatocellular carcinoma
Authors: Dong Hwan Kim, Sang Hyun Choi, Jae Ho Byun, Ji Hun Kang, Young-Suk Lim, So Jung Lee, So Yeon Kim, Hyung Jin Won, Yong Moon Shin, Pyo-Nyun Kim
Journal: Journal of Hepatology (2019)