tbuckley/cabot-search huggingface dataset:
AB1304-HPR KNOWLEDGE OF HIGH SCHOOL STUDENTS ABOUT RHEUMATIC DISEASES: EFFECT OF AN EDUCATIONAL SESSION JOINTLY PROVIDED BY PORTUGUESE EULAR ASSOCIATIONS
Authors: G. Pimentel, A. Marques, R. Ferreira, E. Mateus, A. Pais
Journal: Annals of the Rheumatic Diseases (2020)

Background: International studies have shown that the awareness and knowledge of the general population about rheumatic and musculoskeletal diseases (RMDs) is poor. This is even lower in the young population, which are also affected by these disease but do not have as much awareness campaigns as adult community. Their professors and primary health care professionals may also play here also a key role, promoting early detection of signs and interpretations of symptoms, thus avoiding late health care referrals and diagnosis. (Vlieland, 2016). Objectives: To assess the knowledge of high school Portuguese students about the RMDs and raise awareness for RMDs in young people, their professors, vigilants, and primary care nurses, within the school environment. Methods: A 1-hour educational session about RMDs was planned (with the inputs from members of the Portuguese EULAR Associations) and performed during school activities. The educational session started with a knowledge questionnaire about RMDs in a paper sheet (9 questions; Graph 1), repeated in the end. An interactive session, using slides, interactive questions (Sli.do®), and practical demonstrations to simulate RMD symptoms (e.g. stiffness and functional limitations) was then lead by a rheumatology nurse, with the testimony from a young patient representative. A primary care nurse assisted in order to be engaged and promote future sessions (“autonomously”). Change in knowledge was assessed with Wilcoxon-test and awareness was documented with “word clouds” (using Sli.do®). Results: A total of 75 students participated in four sessions (mode=16 years). Half of students (52%) had never heard about RMDs. Knowledge increased significantly in all questions (p&lt;0.001; Graph 1). Figures 1 and 2 document the most common words representing what defines a RMD and what are the main symptoms, respectively. Conclusion: Our results confirm that awareness and knowledge about RMDs are very low high school students. The single and educational session was very well received by all students, and the the knowledge increased. Post-educational feedback was that students especially liked the testimony of a peer. Other sessions are taking place in primary schools. References: [1]Vlieland, T. P., et al. RMD Open, 2016;2:e000337. doi:10.1136/rmdopen- 2016-000337 Acknowledgments: To European League Against Rheumatism for the founding provided through the campaign “Don’t Delay, Connect Today”. Disclosure of Interests: None declared
Pharmacological Premature Termination Codon Readthrough of ABCB11 in Bile Salt Export Pump Deficiency: An In Vitro Study
Authors: Rachida Amzal, Alice Thébaut, Martine Lapalus, Marion Almes, Brigitte Grosse, Elodie Mareux, Mauricette Collado‐Hilly, Anne Davit‐Spraul, Laure Bidou, Olivier Namy, Emmanuel Jacquemin, Emmanuel Gonzales
Journal: Hepatology (2020)

Progressive familial intrahepatic cholestasis type 2 (PFIC2) is a severe hepatocellular cholestasis due to biallelic mutations in ABCB11 encoding the canalicular bile salt export pump (BSEP). Nonsense mutations are responsible for the most severe phenotypes. The aim was to assess the ability of drugs to induce readthrough of six nonsense mutations (p.Y354X, p.R415X, p.R470X, p.R1057X, p.R1090X, and p.E1302X) identified in patients with PFIC2.The ability of G418, gentamicin, and PTC124 to induce readthrough was studied using a dual gene reporter system in NIH3T3 cells. The ability of gentamicin to induce readthrough and to lead to the expression of a full-length protein was studied in human embryonic kidney 293 (HEK293), HepG2, and Can 10 cells using immunodetection assays. The function of the gentamicin-induced full-length protein was studied by measuring the [3 H]-taurocholate transcellular transport in stable Madin-Darby canine kidney clones co-expressing Na+-taurocholate co-transporting polypeptide (Ntcp). Combinations of gentamicin and chaperone drugs (ursodeoxycholic acid, 4-phenylbutyrate [4-PB]) were investigated. In NIH3T3, aminoglycosides significantly increased the readthrough level of all mutations studied, while PTC124 only slightly increased the readthrough of p.E1302X. Gentamicin induced a readthrough of p.R415X, p.R470X, p.R1057X, and p.R1090X in HEK293 cells. The resulting full-length proteins localized within the cytoplasm, except for BsepR1090X , which was also detected at the plasma membrane of human embryonic kidney HEK293 and at the canalicular membrane of Can 10 and HepG2 cells. Additional treatment with 4-PB and ursodeoxycholic acid significantly increased the canalicular proportion of full-length BsepR1090X protein in Can 10 cells. In Madin-Darby canine kidney clones, gentamicin induced a 40% increase of the BsepR1090X [3 H]-taurocholate transport, which was further increased with additional 4-PB treatment.This study constitutes a proof of concept for readthrough therapy in selected patients with PFIC2 with nonsense mutations.
Identifying optimal cutpoints for quality of life function in patients with advanced cancer
Authors: James F. Grutsch, Christopher G. Lis, Joel Granick, Robert D. Levin, Sybilann Williams, Thom Wodek, Digant Gupta
Journal: Cancer Research (2005)

Proc Amer Assoc Cancer Res, Volume 46, 2005

4197 

Background: Substantial resources have been spent to develop validated quality of life (QoL) tools in cancer. Now QoL research is focusing on utilizing QoL measurements to improve patient outcomes. One potential clinical role for QoL information is to triage patients into good, bad, and uncertain prognosis. Consequently, we used survival analysis to determine if we could transform the continuous scales of QoL data into categorical survival outcomes. Methods: Baseline QoL data were collected from 310 patients treated at our center between 04/01 and 10/03. 2 QoL tools were used: Ferrans and Powers Quality of Life Index (QLI), which has 4 functional domains, and EORTC QLQ-C30, which has 5 functional domains and 9 symptom items. Using the Wilcoxon test, differences in survival were measured in serial increments of 10 points for EORTC and 3 points for QLI (these levels are associated with significant improvement in QoL). Results from Wilcoxon test were plotted as a function of QoL cutoff points. Linear and polynomial solutions were fitted and Wald statistic identified the best fit. Results: Of 310 patients, 180 were females and 130 males, with a median age of 55 years (range 21 - 82). 64.2% had failed prior treatment. Most common cancers were breast (25%), colorectal (23.3%), and lung (17.7%). Statistical analysis indicated that Health and Function Domain (Wald Test P = 0.0194) had two cutpoints at values 10 and 20. We found a statistically significant difference in survival between patients with scores   20, the median survival being 169, 349, and 692 days respectively (p   80 were 450, 413, and 129 days respectively (p < 0.0001). Conclusions: The transformation of a QoL research tool into a clinical management tool is a challenge. As an initial step, we showed that we could convert continuous quality of life scores of the QLI Health and Functioning Domain and the rank ordered fatigue item EORTC QLQ-C30 into categorical survival outcome categories of good, bad, and uncertain. These data suggest that specific QoL domains can be powerful tools to help physicians evaluate their patients’ prognosis and subsequently, facilitate physician/patient thinking on treatment planning.
Optimal International Normalized Ratio Range for Asian Patients on Anticoagulation Therapy
Authors: Lai Heng Lee, Ming Chai Kong, Isabelle Teo, Shun Wei Lim, Jin Shing Hon, Kelly Bee Ling Chng, Sing Lin Tee, Elicia Purnata, Clifton You Xuan Liew, Xin Hui Loh, Cui Mei Fong, Nirmali Ruth Sivapragasam, Yiong Huak Chan, Jiang Ming Fam, Heng Joo Ng, Marcus Eng Hock Ong, David Bruce Matchar
Journal: Blood (2017)
Triamterene, a New Diuretic Drug--II
Authors: W. I. Baba, G. R. Tudhope, G. M. Wilson
Journal: BMJ (1962)

producing an increased excretion of sodium and water but a decrease in potassium excretion.Our findings in normal subjects and in adrenalectomized rats suggested that the diuretic action of triamterene is not due to aldosterone antagonism but probably to a direct action on the renal tubular cells (Baba et al., 1962).The present work describes and compares the various types of responses encountered when hydroflumethiazide, spironolactone, and triamterene were given alone and in combination to patients with chronic salt and water retention.
Asthma exacerbations on benralizumab are largely non‐eosinophilic
Authors: Sophie M. Poznanski, Manali Mukherjee, Nan Zhao, Chynna Huang, Katherine Radford, Ali A. Ashkar, Parameswaran Nair
Journal: Allergy (2020)

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Covid-19: Testing programme for NHS workers must not discriminate, report warns
Authors: Abi Rimmer
Journal: BMJ (2020)

All NHS workers should be given the same access to covid-19 swab testing to avoid variation in access for different groups, a report on the ethics of testing has said.

In a report published on 21 July, Cambridge University’s Healthcare Improvement Studies (THIS) Institute made a number of recommendations to ensure that the covid-19 swab testing programme for NHS workers was carried out ethically.1

The report said that it was important at …
Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3+ Regulatory T Cells via a miR-342-Dependent Mechanism
Authors: Dongkyun Kim, Quang Tam Nguyen, Juyeun Lee, Sung Hwan Lee, Allison Janocha, Sohee Kim, Hongnga T. Le, Nina Dvorina, Kelly Weiss, Mark J. Cameron, Kewal Asosingh, Serpil C. Erzurum, William M. Baldwin, Ju-Seog Lee, Booki Min
Journal: Immunity (2020)
Identifying Risk Factors for Acute and Chronic Graft-Versus-Host Disease in T-Replete HLA-Haploidentical Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide
Authors: Jimena Baron, Michelle Ridgeway, Xu Zhang, Asad Bashey, Scott R Solomon, H. Kent Holland, Lawrence E Morris, Melhem M Solh
Journal: Blood (2017)
National registry will record patient outcomes from devices implanted during vascular surgery
Authors: Elisabeth Mahase
Journal: BMJ (2020)

The UK National Vascular Registry will now record details of medical devices implanted in patients during abdominal aortic aneurysm repair, as well as long term patient outcomes, the Royal College of Surgeons of England has announced.

The register was first launched in 2013 to supply NHS vascular units with information on their performance.1 But it has now been updated to help identify problems with these medical devices as early as possible and prevent their …
Abstract 15229: Safety of Magnetic Resonance Imaging in Patients With a Watchman Device
Authors: Domenico G Della Rocca, Dhanunjaya Lakkireddy, Sanghamitra Mohanty, Rakesh Gopinathannair, Varuna Gadiyaram, Chintan Trivedi, Veronica N Natale, Alessio Gasperetti, Carola Gianni, Gwen Janczyk, Rodney Horton, Amin Al-Ahmad, Javier Sanchez, David J Burkhardt, G J Gallinghouse, Patrick M Hranitzky, Gaetano Fassini, Luigi Di Biase, Claudio Tondo, Douglas Gibson, Andrea Natale
Journal: Circulation (2018)

Introduction: The Watchman device for left atrial appendage occlusion (LAAO) has proven to be effective for stroke prophylaxis in atrial fibrillation patients. The device is made of nitinol (NiTi),...
Beyond Ventilators and Prematurity: Most Rationing Dilemmas Are Morally Fraught
Authors: Anne Sullivan, Sadath Sayeed, Christy L. Cummings
Journal: The American Journal of Bioethics (2020)

In the target article, “Should Extremely Premature Babies Get Ventilators During the COVID-19 Crisis?” (Haward et al. 2020), the authors highlight the importance of giving fair consideration to pre...
Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma
Authors: Lindsay M. LaFave, Vinay K. Kartha, Sai Ma, Kevin Meli, Isabella Del Priore, Caleb Lareau, Santiago Naranjo, Peter M.K. Westcott, Fabiana M. Duarte, Venkat Sankar, Zachary Chiang, Alison Brack, Travis Law, Haley Hauck, Annalisa Okimoto, Aviv Regev, Jason D. Buenrostro, Tyler Jacks
Journal: Cancer Cell (2020)
Comparison of Unsupervised Home Self-collected Midnasal Swabs With Clinician-Collected Nasopharyngeal Swabs for Detection of SARS-CoV-2 Infection
Authors: Denise J. McCulloch, Ashley E. Kim, Naomi C. Wilcox, Jennifer K. Logue, Alex L. Greninger, Janet A. Englund, Helen Y. Chu
Journal: JAMA Network Open (2020)

This diagnostic study compares unsupervised home self-collected midnasal swabs vs clinician-collected nasopharyngeal swabs for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Ventilator Allocation for Pediatrics during COVID-19 – How We Avoided Drawing Lots for Tots
Authors: Neil D. Fernandes, Kelly Gardner, John J. Paris, Brian M. Cummings
Journal: The American Journal of Bioethics (2020)

It took millennia for the medical community to recognize that the Hippocratic insistence on “the physician knows best” was an inadequate approach to medicine. During a pandemic of unprecedented pro...
A Phase II Study of Abemaciclib in Patients with Brain Metastases Secondary to Hormone Receptor–Positive Breast Cancer
Authors: Sara M. Tolaney, Solmaz Sahebjam, Emilie Le Rhun, Thomas Bachelot, Peter Kabos, Ahmad Awada, Denise Yardley, Arlene Chan, Pierfranco Conte, Véronique Diéras, Nancy U. Lin, Melissa Bear, Sonya C. Chapman, Zhengyu Yang, Yanyun Chen, Carey K. Anders
Journal: Clinical Cancer Research (2020)

The primary objective was to evaluate intracranial objective response rate (iORR) in patients receiving abemaciclib with brain or leptomeningeal metastases (LM) secondary to hormone receptor-positive (HR+) metastatic breast cancer (MBC). Secondary objectives evaluated extracranial response, abemaciclib pharmacokinetics, brain metastases tissue exposure, and safety.This nonrandomized, phase II study (NCT02308020) enrolled patients in tumor subtype-specific cohorts A-D: A (HR+, HER2- MBC), B (HR+, HER2+ MBC), C (HR+ MBC LM), and D (brain metastases surgical resection). Abemaciclib 200 mg was administered twice daily as monotherapy or with endocrine therapy, or 150 mg twice daily with trastuzumab. Cohorts A and B used a Simon two-stage design.In cohort A (n = 58), 3 patients were confirmed responders resulting in an iORR of 5.2% [95% confidence interval (CI), 0.0-10.9], and the intracranial clinical benefit rate (iCBR) was 24% (95% CI, 13.1-35.2). Median overall survival (OS) was 12.5 months (95% CI, 9.3-16.4). A volumetric decrease in target intracranial lesions was experienced by 38% of patients. In cohort B (n = 27), there were no confirmed intracranial responses. An iCBR of 11% (95% CI, 0.0-23.0) was observed. Median OS was 10.1 months (95% CI, 4.2-14.3). A volumetric decrease in target intracranial lesions was experienced by 22% of patients. In cohort C (n = 10), one confirmed complete parenchymal response was observed. In cohort D (n = 9), unbound brain metastases concentrations of total active abemaciclib analytes were 96- [cyclin-dependent kinase 4 (CDK4)] and 19-fold (CDK6) above in vitro IC50. Safety was consistent with prior studies.This study did not meet its primary endpoint. Abemaciclib was associated with an iCBR of 24% in patients with heavily pretreated HR+, HER2- MBC. Abemaciclib achieved therapeutic concentrations in brain metastases tissue, far exceeding those necessary for CDK4 and CDK6 inhibition. Further studies are warranted, including assessing novel abemaciclib-based combinations.
Urine steroid metabolomics for the differential diagnosis of adrenal incidentalomas in the EURINE-ACT study: a prospective test validation study
Authors: Irina Bancos, Angela E Taylor, Vasileios Chortis, Alice J Sitch, Carl Jenkinson, Caroline J Davidge-Pitts, Katharina Lang, Stylianos Tsagarakis, Magdalena Macech, Anna Riester, Timo Deutschbein, Ivana D Pupovac, Tina Kienitz, Alessandro Prete, Thomas G Papathomas, Lorna C Gilligan, Cristian Bancos, Giuseppe Reimondo, Magalie Haissaguerre, Ljiljana Marina, Marianne A Grytaas, Ahmed Sajwani, Katharina Langton, Hannah E Ivison, Cedric H L Shackleton, Dana Erickson, Miriam Asia, Sotiria Palimeri, Agnieszka Kondracka, Ariadni Spyroglou, Cristina L Ronchi, Bojana Simunov, Danae A Delivanis, Robert P Sutcliffe, Ioanna Tsirou, Tomasz Bednarczuk, Martin Reincke, Stephanie Burger-Stritt, Richard A Feelders, Letizia Canu, Harm R Haak, Graeme Eisenhofer, M Conall Dennedy, Grethe A Ueland, Miomira Ivovic, Antoine Tabarin, Massimo Terzolo, Marcus Quinkler, Darko Kastelan, Martin Fassnacht, Felix Beuschlein, Urszula Ambroziak, Dimitra A Vassiliadi, Michael W O'Reilly, William F Young, Michael Biehl, Jonathan J Deeks, Wiebke Arlt, Stephan Glöckner, Richard O. Sinnott, Anthony Stell, Maria C. Fragoso, Darko Kastelan, Ivana D. Pupovac, Bojana Simunov, Sarah Cazenave, Magalie Haissaguerre, Antoine Tabarin, Jérôme Bertherat, Rossella Libé, Tina Kienitz, Marcus Quinkler, Katharina Langton, Graeme Eisenhofer, Felix Beuschlein, Christina Brugger, Martin Reincke, Anna Riester, Ariadni Spyroglou, Stephanie Burger-Stritt, Timo Deutschbein, Martin Fassnacht, Stefanie Hahner, Matthias Kroiss, Cristina L. Ronchi, Sotiria Palimeri, Stylianos Tsagarakis, Ioanna Tsirou, Dimitra A. Vassiliadi, Vittoria Basile, Elisa Ingargiola, Giuseppe Reimondo, Massimo Terzolo, Letizia Canu, Massimo Mannelli, Hester Ettaieb, Harm R. Haak, Thomas M. Kerkhofs, Michael Biehl, Richard A. Feelders, Johannes Hofland, Leo J. Hofland, Marianne A. Grytaas, Eystein S. Husebye, Grethe A. Ueland, Urszula Ambroziak, Tomasz Bednarczuk, Agnieszka Kondracka, Magdalena Macech, Malgorzata Zawierucha, Isabel Paiva, M. Conall Dennedy, Ahmed Sajwani, Mark Sherlock, Rachel K. Crowley, Miomira Ivovic, Ljiljana Marina, Jonathan J. Deeks, Alice J. Sitch, Wiebke Arlt, Irina Bancos, Vasileios Chortis, Lorna C. Giligan, Beverly A. Hughes, Katharina Lang, Hannah E. Ivison, Carl Jenkinson, Konstantinos Manolopoulos, Donna M. O'Neil, Michael W. O'Reilly, Thomas G. Papathomas, Alessandro Prete, Cedric H.L. Shackleton, Angela E. Taylor, Miriam Asia, Robert P. Sutcliffe, Peter Guest, Kassiani Skordilis, Cristian Bancos, Alice Chang, Caroline J. Davidge-Pitts, Danae A. Delivanis, Dana Erickson, Neena Natt, Todd B. Nippoldt, Melinda Thomas, William F. Young Jr.
Journal: The Lancet Diabetes & Endocrinology (2020)

Cross-sectional imaging regularly results in incidental discovery of adrenal tumours, requiring exclusion of adrenocortical carcinoma (ACC). However, differentiation is hampered by poor specificity of imaging characteristics. We aimed to validate a urine steroid metabolomics approach, using steroid profiling as the diagnostic basis for ACC.
Success of Antibiotic Therapy vs Laparoscopic Appendectomy for Uncomplicated Appendicitis in Children
Authors: Edward H. Livingston
Journal: JAMA (2020)

Peter C. Minneci, MD, MHSc; Erinn M. Hade, PhD; Amy E. Lawrence, MD; Yuri V. Sebastião, PhD; Jacqueline M. Saito, MD; Grace Z. Mak, MD; Christa Fox, MSN; Ronald B. Hirschl, MD; Samir Gadepalli, MD, MBA; Michael A. Helmrath, MD; Jonathan E. Kohler, MD; Charles M. Leys, MD; Thomas T. Sato, MD; Dave R. Lal, MD; Matthew P. Landman, MD; Rashmi Kabre, MD; Mary E. Fallat, MD; Jennifer N. Cooper, PhD; Katherine J. Deans, MD, MHSc; for the Midwest Pediatric Surgery Consortium
Cystic Fibrosis Lung Transplant Recipients Have Suppressed Airway Interferon Responses during Pseudomonas Infection
Authors: Daniel T. Dugger, Monica Fung, Lorna Zlock, Saharai Caldera, Louis Sharp, Steven R. Hays, Jonathan P. Singer, Lorriana E. Leard, Jefferey A. Golden, Rupal J. Shah, Jasleen Kukreja, Erin Gordon, Walter Finkbeiner, Mary Ellen Kleinhenz, Chaz Langelier, John R. Greenland
Journal: Cell Reports Medicine (2020)

Lung transplantation can be lifesaving in end-stage cystic fibrosis (CF), but long-term survival is limited by chronic lung allograft dysfunction (CLAD). Persistent upper airway Pseudomonas aeruginosa (PsA) colonization can seed the allograft. While de novo PsA infection is associated with CLAD in non-CF recipients, this association is less clear for CF recipients experiencing PsA recolonization. Here, we evaluate host and pathogen contributions to this phenomenon. In the context of PsA infection, brushings from the airways of CF recipients demonstrate type 1 interferon gene suppression. Airway epithelial cell (AEC) cultures demonstrate similar findings in the absence of pathogens or immune cells, contrasting with the pre-transplant CF AEC phenotype. Type 1 interferon promoters are relatively hypermethylated in CF AECs. CF subjects in this cohort have more mucoid PsA, while non-CF PsA subjects have decreased microbiome α diversity. Peri-transplant protocols may benefit from consideration of this host and microbiome equilibrium.
Neutrophil activation in Alzheimer’s disease and mild cognitive impairment: A systematic review and meta-analysis of protein markers in blood and cerebrospinal fluid
Authors: Che-Yuan Wu, Kritleen K. Bawa, Michael Ouk, Nathan Leung, Di Yu, Krista L. Lanctôt, Nathan Herrmann, Maureen Pakosh, Walter Swardfager
Journal: Ageing Research Reviews (2020)
THU0152 THE ADVANTAGES OF DISTANCE BLOOD PRESSURE MONITORING IN PATIENTS WITH RHEUMATOID ARTHRITIS
Authors: I. Starodubtseva, J. Sharapova
Journal: Annals of the Rheumatic Diseases (2020)

Background: Cardiovascular complications are very common in patients with rheumatoid arthritis (RA). The monitoring of the course of RA and comorbid conditions is the key aspect of the prevention of early mortality. Objectives: To evaluate the effectiveness of the use of distance monitoring of blood pressure (BP) in patients with rheumatoid arthritis (RA) with comorbid arterial hypertension (AH). Methods: 200 RA patients with AH (SBP – systolic 162.1 ± 7.3, DBP - diastolic 94.9 ± 9.2) are included in the trial, of which 8% are men. The average age was 54.0 ± 13.0. Patients were divided into 2 groups. Patients of group 1 (n=100) independently measured BP twice a day and entered the SBP and DBP results on self-control diaries in electronic form, or transmitted data from the tonometer via the installed mobile application. Pts of group 2 (n=100) were consulted on the first visit and in 3 months with further recommendations of monitoring and treatment of RA and AH. Results: Activity on DAS 28 (CRP), pain on VAS (mm), level of cholesterol, age and prednisolone use significant moderate correlated (p&lt;0.01) with the level of SBP. In 6 months the average level of SBP and DBP were 131.4 ± 8.2 and 82.6 ± 5.1 mm Hg in group 1 respectively. In group 1 80% of pts achieved target BP in comparison with 50% of pts in group 2. The frequency of prescribing of two-component and three-component antihypertensive therapy increased in 1.8 and 1.9 times in 1 group; in 1.4 and 1.3 times respectively. Conclusion: Distance BP monitoring in patients with RA with the use of BP monitors with the function of remote data transmission lets to achieve target BP and hereby, reduce the incidence of adverse cardiovascular complications Disclosure of Interests: None declared