tbuckley/cabot-search huggingface dataset:
The Evolutionary Forces Shaping Cis- and Trans-Regulation of Gene Expression within a Population of Outcrossing Plants
Authors: Emily B Josephs, Young Wha Lee, Corlett W Wood, Daniel J Schoen, Stephen I Wright, John R Stinchcombe
Journal: Molecular Biology and Evolution (2020)

Abstract Understanding the persistence of genetic variation within populations has long been a goal of evolutionary biology. One promising route toward achieving this goal is using population genetic approaches to describe how selection acts on the loci associated with trait variation. Gene expression provides a model trait for addressing the challenge of the maintenance of variation because it can be measured genome-wide without information about how gene expression affects traits. Previous work has shown that loci affecting the expression of nearby genes (local or cis-eQTLs) are under negative selection, but we lack a clear understanding of the selective forces acting on variants that affect the expression of genes in trans. Here, we identify loci that affect gene expression in trans using genomic and transcriptomic data from one population of the obligately outcrossing plant, Capsella grandiflora. The allele frequencies of trans-eQTLs are consistent with stronger negative selection acting on trans-eQTLs than cis-eQTLs, and stronger negative selection acting on trans-eQTLs associated with the expression of multiple genes. However, despite this general pattern, we still observe the presence of a trans-eQTL at intermediate frequency that affects the expression of a large number of genes in the same coexpression module. Overall, our work highlights the different selective pressures shaping variation in cis- and trans-regulation.
Finally, a Successful Randomized Trial for GVHD
Authors: Nelson Chao
Journal: New England Journal of Medicine (2020)

For the past half century, we have been attempting to understand graft-versus-host disease (GVHD), at times randomly and more recently in a methodical manner. It became clear early on that GVHD, especially acute GVHD (which occurs primarily in the first few months in the course of allogeneic hematopoietic-cell transplantation), is caused by donor T cells recognizing allogeneic host antigens. Immune suppression or selective depletion of these donor T cells has been successful, but GVHD still occurs in 30 to 70% of recipients of allogeneic hematopoietic-cell transplantation.1 Glucocorticoids have been the first-line therapy and are effective in approximately half the patients. . . .
Abstract 12972: Ultrasound of the Spleen Reduces Myocardial Ischemia-Reperfusion Injury by Stimulating a Splenic Anti-inflammatory Pathway
Authors: Yikui Tian, Joseph C Gigliotti, Di Wu, Alexander L Klibanov, Irving L Kron, Zequan Yang
Journal: Circulation (2015)

Background: Accumulating evidence now shows that a cardio-splenic axis plays critical role in post-ischemic reperfusion injury of the heart. Here, we tested a nonpharmacologic, noninvasive, ultrasound-based treatment of the spleen to reduce myocardial ischemia-reperfusion injury in mice. Methods and Results: C57BL6 (B6) mice and IL-10 Knockout (KO) mice underwent 40 min of LAD occlusion followed by 60 min of reperfusion. Ultrasound of the spleen (US-treated, US-T) versus ultrasound of the liver (US-control, US-C) was performed 24 hours before LAD occlusion. The TTC &amp; Blue staining results showed that risk regions of all groups were identical. US-treated mice had significantly smaller myocardial infarct size than the US-control mice (p&lt;0.05). In B6 mice, splenectomy (SPLX) performed 30 min before ischemia reduced infarct size. Acute adoptive transfer of splenocytes (SPAT) from US-control B6 mice performed 25 min before ischemia significantly exacerbated the infarct size in SPLX mice. However, SPAT of the US-treated splenocytes abrogated this exacerbation of the infarct size (Figure). Western blot analysis showed that ultrasound significantly increased the splenic phosphorylation Akt levels at 24 hours after US treatment. Furthermore, splenic ultrasound failed to protect the myocardial ischemia-reperfusion injury in IL-10 KO mice. Conclusions: These results suggested that an ultrasound-based treatment could have therapeutic potential for attenuation of post-ischemic myocardial reperfusion injury, possibly by stimulating a splenic anti-inflammatory effect via an Akt-IL-10 Pathway.
α-メチルアシル-CoAラセマーゼ(AMACR):代謝酵素,薬物代謝能および癌マーカーP504S | 文献情報 | J-GLOBAL 科学技術総合リンクセンター
Authors: D Lloyd Matthew, Yevglevskis Maksims, Lee Guat Ling, J Wood Pauline, D Threadgill Michael, J Woodman Timothy
Journal: Progress in Lipid Research (2013)
Abstract 15978: The Lifestyle Physical Activity for Sedentary Older Women (LPAW) Study: Primary Outcomes From a Randomized Controlled Clinical Trial
Authors: Leanne L Lefler, Jean C McSweeney, Shelly Y Lensing, Kimberly K Garner, Patricia K Dubbert, Kathy A Packard
Journal: Circulation (2015)

Introduction: Evidence is clear that a physically active lifestyle reduces the human and economic cost of heart disease in a dose-response relationship; but current efforts to increase long-term physical activity (PA) are inadequate. Purpose/hypothesis: To test whether a parsimonious and tailored motivational interviewing (MInt) intervention would increase home-based PA. Methods: We conducted a single-blinded randomized controlled study of sedentary women aged 60 years and older to test a MInt counseling intervention for PA. Lifestyle physical activity was promoted by 2 one-on-one counseling sessions and coaching telephone calls tapering in frequency over 6 months. Women wore Triaxial accelerometers for 7 days to collect data at 0-, 3-, and 6-months to include vector magnitude activity counts, time spent in sedentary, light, moderate and vigorous activity, time spent in lifestyle PA bouts, sedentary time and daily energy expenditure. Results: 123 older women (mean age 69; 64% White; 34% African American) without significant functional or cognitive impairment were randomized to the MInt intervention or PA information/attention control groups. Risk factor profiles designated participants at high-risk for coronary heart disease (70% hypertensive, 48% hyperlipidemic, 25% diabetic, mean BMI 31). At baseline (Time 0) PA was similar; at Time 3 and 6 months the MInt group increased step counts per day (0=3.3K vrs 3.7K; 3=4.2K vrs 3.8K; 6= 4.0K vrs 3.5K) vector magnitude activity counts (0=322K vrs 335K; 3=370K vrs 336K; 6=344K vrs 318K), time in moderate to vigorous activity (0=225 minutes/week vrs 244; 3=288 vrs 247; 6= 261 vrs 225) significantly greater when compared to Control (all with p &lt; .05). PA bouts remained greater and overall sedentary behavior was reduced in the MInt group and maintained over time. Conclusions: The LPAW intervention was successful in improving home-based PA over 6 months and should be tested broadly in other populations.
Updated Results of the Phase II Trial of Inotuzumab Ozogamicin (INO) Combined with Mini-Hyper-CVD As Salvage Therapy for Relapsed/Refractory (R/R) B-Cell Acute Lymphoblastic Leukemia (B-ALL)
Authors: Rita Assi, Hagop M. Kantarjian, Rita Khouri, Farhad Ravandi, Partow Kebriaei, Nicholas J Short, Deborah A Thomas, Guillermo Garcia-Manero, Richard E Champlin, Tapan Kadia, Jorge E. Cortes, Nitin Jain, Marina Konopleva, Zeev Estrov, Koichi Takahashi, Koji Sasaki, Jovitta Jacob, Ameena Manzoor, Rebecca Garris, Susan M. O'Brien, Elias J. Jabbour
Journal: Blood (2017)
Regional Left Ventricular Myocardial Work Indices and Response to Cardiac Resynchronization Therapy
Authors: Marina V. Kostyukevich, Pieter van der Bijl, Ngoc Mai Vo, Rodolfo P. Lustosa, Stephan M. Pio, Marianne Bootsma, Nina Ajmone Marsan, Victoria Delgado, Jeroen J. Bax
Journal: JACC. Cardiovascular imaging (2020)
Acute inflammatory cardiomyopathy: apparent neutral prognostic impact of immunosuppressive therapy
Authors: Marco Merlo, Piero Gentile, Andrea Ballaben, Jessica Artico, Matteo Castrichini, Aldostefano Porcari, Antonio Cannatà, Andrea Perkan, Rossana Bussani, Gianfranco Sinagra
Journal: European Journal of Heart Failure (2020)
A myeloid neoplasm with <scp><i>FIP1L1‐PDGFRA</i></scp> presenting as acute myeloid leukemia
Authors: Félix L. Cadenas, Beatriz R. Bua, María D. Campelo, Jean‐Baptiste Rieu, Barbara J. Bain
Journal: American Journal of Hematology (2020)

A 30-year-old Spanish woman presented with recurrent respiratory tract infections over several months, together with asthenia, and swelling of the abdomen and legs. On examination, she had hepatosplenomegaly, ascites and edema of both legs. Computed tomography confirmed these observations and, in addition, showed bilateral pleural effusions. Her blood count showed: white cell count 17.45 × 109/L, hemoglobin concentration 96 g/L, mean cell volume 93 fL, and platelet count 99 × 109/L. There was marked eosinophilia (5.2 × 109/L) and mild monocytosis (1.05 × 109/L) with small numbers of granulocyte precursors and 6% blast cells. Eosinophils showed cytological abnormalities including vacuolation, hypogranularity, hypolobation, hyperlobation and basophilic granules in mature eosinophils (images, ×100 objective). Blast cells were medium-sized with a high nucleocytoplasmic ratio and fine azurophilic granules. A bone marrow aspirate showed 25%–30% blast cells and more than 20% eosinophils, these showing similar cytological abnormalities to those in the peripheral blood. Cytogenetic analysis was normal but fluorescence in situ hybridization showed the presence of FIP1L1-PDGFRA. A diagnosis of myeloid neoplasm with PDGFRA rearrangement presenting as acute myeloid leukemia (AML) was made. Subsequent next generation sequencing showed two subclonal mutations in BCORL1 (variant allele frequency 8.4%) and PTPN11 (variant allele frequency 7.4%). The patient was treated with imatinib in an initial does of 400 mg daily for 2 weeks and then 200 mg daily, without chemotherapy, and entered rapid remission. After 4 months on 200 mg daily of imatinib she is well with a normal blood count. Because of their sensitivity to tyrosine kinase inhibitors, the identification of neoplasms with rearrangement of PDGFRA or PDGFRB is of considerable importance. Even patients presenting in blast phase can have a complete hematologic and molecular remission that is sustained.1 Nothing to report.
Diarrhea Is Associated With Prolonged Symptoms and Viral Carriage in Corona Virus Disease 2019
Authors: Xiao-Shan Wei, Xu Wang, Yi-Ran Niu, Lin-Lin Ye, Wen-Bei Peng, Zi-Hao Wang, Wei-Bing Yang, Bo-Han Yang, Jian-Chu Zhang, Wan-Li Ma, Xiao-Rong Wang, Qiong Zhou
Journal: Clinical Gastroenterology and Hepatology (2020)
In patients with no indication for anticoagulation after TAVR, rivaroxaban increased adverse events vs antiplatelets
Authors: Wern Yew Ding, Mark Field, Gregory Y.H. Lip
Journal: Annals of Internal Medicine (2020)

ACP Journal Club21 April 2020In patients with no indication for anticoagulation after TAVR, rivaroxaban increased adverse events vs antiplateletsWern Yew Ding, MBChB, Mark Field, DPhil (Oxon), FRCS (C-Th), Gregory Y.H. Lip, MDWern Yew Ding, MBChBUniversity of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, England, UK (W.Y.D., M.F., G.Y.L.)Search for more papers by this author, Mark Field, DPhil (Oxon), FRCS (C-Th)University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, England, UK (W.Y.D., M.F., G.Y.L.)Search for more papers by this author, Gregory Y.H. Lip, MDUniversity of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, England, UK (W.Y.D., M.F., G.Y.L.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJ202004210-040 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationDangas GD, Tijssen JGP, Wöhrle J, et al. A controlled trial of rivaroxaban after transcatheter aortic-valve replacement. N Engl J Med. 2020;382:120-9. https://pubmed.ncbi.nlm.nih.gov/31733180Clinical Impact RatingsCardiology: Reference1 Siddamsetti S, Balasubramanian S, Yandrapalli S, et al. Meta-analysis comparing dual antiplatelet therapy versus single antiplatelet therapy following transcatheter aortic valve implantation. Am J Cardiol. 2018;122:1401-8. [PMID: 30340696] Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, England, UK (W.Y.D., M.F., G.Y.L.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M19-3041.This article was published at Annals.org on 7 April 2020. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 21 April 2020Volume 172, Issue 8Page: JC40KeywordsAntiplatelet therapyAortic valve replacementAspirinAtrial fibrillationHazard ratioHemorrhageMortalityMyocardial infarctionSafetyVitamin K ePublished: 21 April 2020 Issue Published: 21 April 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Hematopoietic cell transplantation utilization and outcomes for primary plasma cell leukemia in the current era
Authors: Binod Dhakal, Sagar Patel, Saulius Girnius, Lohith Bachegowda, Raphael Fraser, Omar Davila, Abraham S. Kanate, Amer Assal, Amr Hanbali, Asad Bashey, Attaphol Pawarode, César O. Freytes, Cindy Lee, David Vesole, Robert Frank Cornell, Gerhard C. Hildebrandt, Hemant S. Murthy, Hillard M. Lazarus, Jan Cerny, Jean A. Yared, Jeffrey Schriber, Jesus Berdeja, Keith Stockerl-Goldstein, Kenneth Meehan, Leona Holmberg, Melhem Solh, Miguel Angel Diaz, Mohamed A. Kharfan-Dabaja, Nosha Farhadfar, Qaiser Bashir, Reinhold Munker, Richard F. Olsson, Robert P. Gale, Ruthlee-Lu Bayer, Sachiko Seo, Saurabh Chhabra, Shahrukh Hashmi, Sherif M. Badawy, Taiga Nishihori, Wilson Gonsalves, Yago Nieto, Yvonne Efebera, Shaji Kumar, Nina Shah, Muzaffar Qazilbash, Parameswaran Hari, Anita D’Souza
Journal: Leukemia (2020)
Role of Consolidation Therapy in the Treatment of Patients up to 60 Years with High Risk AML.
Authors: Jürgen Krauter, Gerhard Heil, Dieter Hoelzer, Oliver Ottmann, Hans Martin, Michael Lübbert, Jürgen Finke, Wolf Heit, Walter Fiedler, Lothar Kanz, Peter Brossart, Günter Schlimok, Hartmut Kirchner, Aruna Raghavachar, Wolfram Brugger, Arnold Ganser
Journal: Blood (2005)
Depletion of Host CD122+ Cells Facilitates Widespread Skeletal Multiple Myeloma Engraftment in NOD/SCID Recipients
Authors: Lisa M Freeman, Eugene Petcu, Robert Smith, Ali Salajegheh, Peter Diamond, Andrew Christopher William Zannettino, Andreas Evdokiou, John Luff, Dalia Khalil, Frank Vari, Lawrence Catley, Derek Hart, Slavica Vuckovic
Journal: Blood (2008)
EAN/ERS/ESO/ESRS statement on the impact of sleep disorders on risk and outcome of stroke
Authors: Claudio L.A. Bassetti, Winfried Randerath, Luca Vignatelli, Luigi Ferini-Strambi, Anne-Kathrin Brill, Maria R. Bonsignore, Ludger Grote, Poul Jennum, Didier Leys, Jens Minnerup, Lino Nobili, Thomy Tonia, Rebecca Morgan, Joel Kerry, Renata Riha, Walter T. McNicholas, Vasileios Papavasileiou
Journal: European Respiratory Journal (2020)

Sleep disorders are highly prevalent in the general population and may be linked in a bidirectional fashion to stroke, which is one of the leading causes of morbidity and mortality. Four major scientific societies established a task force of experts in neurology, stroke, respiratory medicine, sleep medicine and methodology, to critically evaluate the evidence regarding potential links and the impact of therapy. 13 research questions were evaluated in a systematic literature search using a stepwise hierarchical approach: first, systematic reviews and meta-analyses; second, primary studies post-dating the systematic reviews/meta-analyses. A total of 445 studies were evaluated and 88 included. Statements were generated regarding current evidence and clinical practice. Severe obstructive sleep apnoea (OSA) doubles the risk for incident stroke, especially in young to middle-aged patients. Continuous positive airway pressure (CPAP) may reduce stroke risk, especially in treatment-compliant patients. The prevalence of OSA is high in stroke patients and can be assessed by polygraphy. Severe OSA is a risk factor for recurrence of stroke and may be associated with stroke mortality, while CPAP may improve stroke outcome. It is not clear if insomnia increases stroke risk, while pharmacotherapy of insomnia may increase it. Periodic limb movements in sleep (PLMS), but not restless limb syndrome (RLS), may be associated with an increased risk of stroke. Preliminary data suggest a high frequency of post-stroke insomnia and RLS and their association with a less favourable stroke outcome, while treatment data are scarce. Overall, the evidence base is best for OSA relationship with stroke and supports active diagnosis and therapy. Research gaps remain especially regarding insomnia and RLS/PLMS relationships with stroke.
Enhancing the magnetic relaxivity of MRI contrast agents via the localized superacid microenvironment of graphene quantum dots
Authors: Yongqiang Li, Hui Dong, Quan Tao, Caichao Ye, Mengmeng Yu, Jipeng Li, Huifang Zhou, Siwei Yang, Guqiao Ding, Xiaoming Xie
Journal: Biomaterials (2020)
Guillain–Barré Syndrome Associated with SARS-CoV-2
Authors: Gianpaolo Toscano, Francesco Palmerini, Sabrina Ravaglia, Luigi Ruiz, Paolo Invernizzi, M. Giovanna Cuzzoni, Diego Franciotta, Fausto Baldanti, Rossana Daturi, Paolo Postorino, Anna Cavallini, Giuseppe Micieli
Journal: New England Journal of Medicine (2020)

Guillain–Barre Syndrome with Covid-19 Five patients who had Guillain–Barre syndrome 5 to 10 days after the onset of Covid-19 are described. Three had severe weakness and an axonal pattern on electr...
Rapid identification and isolation of neuraminidase inhibitors from mockstrawberry (Duchesnea indica Andr.) based on ligand fishing combined with HR-ESI-Q-TOF-MS
Authors: Sifan Luo, Linbo Guo, Caimin Sheng, Yumei Zhao, Ling Chen, Chufang Li, Zhengjin Jiang, Haiyan Tian
Journal: Acta Pharmaceutica Sinica B (2020)

Neuraminidase inhibitors (NAIs) are the mainstay antiviral drugs against influenza infection. In this study, a ligand fishing protocol was developed to screen NAIs using neuraminidase immobilized magnetic beads (NA-MB). After verifying the feasibility of NA-MB with an artificial mixture including NA inhibitors and non-inhibitors, the developed ligand fishing protocol was applied to screen NAIs from the crude extracts of Duchesnea indica Andr. Twenty-four NA binding compounds were identified from the normal butanol (n-BuOH) extract of D. indica as potential NAIs by high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF-MS) assisted with Compound Structure Identification (CSI):FingerID, including 12 ellagitannins, 4 brevifolin derivatives, 3 ellagic acid derivatives, and 4 flavonoids. Among them, 9 compounds were isolated and tested for in vitro NA inhibitory activities against NA from Clostridium perfringens, and from oseltamivir sensitive and resistant influenza A virus strains. The results indicate that compound B23 has the NA inhibitory activities in both the oseltamivir sensitive and resistant viral NA, with half maximal inhibitory concentration (IC50) values of 197.9 and 125.4 μmol/L, respectively. Moreover, B23 can obviously reduce the replication of oseltamivir sensitive and resistant viruses in Madin-Darby canine kidney (MDCK) cells at the concentrations of 40 and 200 μmol/L.
Participation of the ATR/CHK1 pathway in replicative stress targeted therapy of high-grade ovarian cancer
Authors: Patrycja Gralewska, Arkadiusz Gajek, Agnieszka Marczak, Aneta Rogalska
Journal: Journal of Hematology & Oncology (2020)

Abstract Ovarian cancer is one of the most lethal gynecologic malignancies reported throughout the world. The initial, standard-of-care, adjuvant chemotherapy in epithelial ovarian cancer is usually a platinum drug, such as cisplatin or carboplatin, combined with a taxane. However, despite surgical removal of the tumor and initial high response rates to first-line chemotherapy, around 80% of women will develop cancer recurrence. Effective strategies, including chemotherapy and new research models, are necessary to improve the prognosis. The replication stress response (RSR) is characteristic of the development of tumors, including ovarian cancer. Hence, RSR pathway and DNA repair proteins have emerged as a new area for anticancer drug development. Although clinical trials have shown poly (ADP-ribose) polymerase inhibitors (PARPi) response rates of around 40% in women who carry a mutation in the BRCA1/2 genes, PARPi is responsible for tumor suppression, but not for complete tumor regression. Recent reports suggest that cells with impaired homologous recombination (HR) activities due to mutations in TP53 gene or specific DNA repair proteins are specifically sensitive to ataxia telangiectasia and Rad3-related protein (ATR) inhibitors. Replication stress activates DNA repair checkpoint proteins (ATR, CHK1), which prevent further DNA damage. This review describes the use of DNA repair checkpoint inhibitors as single agents and strategies combining these inhibitors with DNA-damaging compounds for ovarian cancer therapy, as well as the new platforms used for optimizing ovarian cancer therapy.
Treatment of High Risk DLBCL with DA-R-EPOCH in Those Unable to Tolerate Intensive Chemotherapy: Well-Tolerated and Effective, but Inadequate in Double/Triple Hit or Expressing DLBCL
Authors: Lori A. Leslie, Sejal Kothadia, Ewelina Protomastro, Patricia J Greenberg, Tracy Andrews, Ann McNeill, Hoshiyuki Iida, Alan P Skarbnik, Xiao Yang, Pritish K. Bhattacharyya, Kar Fai Chow, Stuart L. Goldberg, Andrew L. Pecora, Tatyana A Feldman, Andre Goy
Journal: Blood (2017)
Risk factors for severe COVID-19: Evidence from 167 hospitalized patients in Anhui, China
Authors: Yuan-Yuan Wei, Rui-Rui Wang, Da-Wei Zhang, You-Hui Tu, Chang-Shan Chen, Shuang Ji, Chun-Xi Li, Xiu-Yong Li, Meng-Xi Zhou, Wen-Sheng Cao, Ming-Feng Han, Guang-He Fei
Journal: Journal of Infection (2020)
Increased Procoagulant Cell-Derived Microparticles (MP) in Splenectomized Patients with ITP: New Prediisposing Factors for Thrombosis.
Authors: Vincenzo Fontana, Wenche Jy, Pamela Dudkiewicz, Miriam Yaniz, Carlos J. Bidot, Joaquin J. Jimenez, Yeon S. Ahn
Journal: Blood (2005)