tbuckley/cabot-search huggingface dataset:
Gut microbiome in rheumatic diseases
Authors: Sergey Moiseev, Vilen Rameev, Ekaterina Karovaikina, Lidia Lysenko (Kozlovskaya)
Journal: Annals of the Rheumatic Diseases (2019)

In a recent study, Deshayes et al used 16S ribosomal RNA gene sequencing to analyse the gut microbiome in patients with familial Mediterranean fever (FMF) complicated or not by AA amyloidosis and in patients with AA amyloidosis of another origin.1 Compared with healthy controls, FMF was associated with decreased α-diversity (ie, microbial richness and evenness) and altered composition of the gut microbiome. Certain operational taxonomy units (OTUs) belonging to the Clostridiales were associated with FMF, whereas two OTUs were overrepresented in AA amyloidosis among FMF patients. The authors suggested that intestinal microorganisms may play a role in the clinical expression and pathogenesis of these diseases. In a similar study, decreased species richness diversity was shown in the microbiome of patients with systemic lupus erythematosus (SLE). Moreover, SLE was associated with intestinal outgrowth of Ruminococcus gnavus of the Lachnospiraceae family that was most pronounced in those with lupus nephritis and correlated with disease activity.2

These and previous studies in spondyloarthritis and rheumatoid arthritis reflect the growing interest of researchers to the role …
Deficiency in Embryonic Stem Cell Marker Reduced Expression 1 Activates Mitogen‐Activated Protein Kinase Kinase 6–Dependent p38 Mitogen‐Activated Protein Kinase Signaling to Drive Hepatocarcinogenesis
Authors: Steve T. Luk, Kai‐Yu Ng, Lei Zhou, Man Tong, Tin‐Lok Wong, Huajian Yu, Chung‐Mau Lo, Kwan Man, Xin‐Yuan Guan, Terence K. Lee, Stephanie Ma
Journal: Hepatology (2019)

Background and Aims Embryonic stem‐cell–related transcription factors are central to the establishment and maintenance of stemness and pluripotency, and their altered expression plays key roles in tumors, including hepatocellular carcinoma (HCC), a malignancy with no effective treatment. Here, we report on the embryonic stem cell marker, reduced expression 1 (REX1; also known as zinc finger protein 42), to be selectively down‐regulated in HCC tumors. Approach and Results Deficiency of REX1 in HCC was attributed to a combination of hypermethylation at its promoter as well as histone modification by methylation and acetylation. Clinically, hypermethylation of REX1 was closely associated with neoplastic transition and advanced tumor stage in humans. Functionally, silencing of REX1 potentiated the tumor‐initiating and metastasis potential of HCC cell lines and xenografted tumors. Lentivirus‐mediated Rex1 ablation in liver of male immunocompetent mice with HCC, induced by hydrodynamic tail vein injection of proto‐oncogenes, enhanced HCC development. Transcriptome profiling studies revealed REX1 deficiency in HCC cells to be enriched with genes implicated in focal adhesion and mitogen‐activated protein kinase (MAPK) signaling. From this lead, we subsequently found REX1 to bind to the promoter region of mitogen‐activated protein kinase kinase 6 (MKK6), thereby obstructing its transcription, resulting in altered p38 MAPK signaling. Conclusions Our work describes a critical repressive function of REX1 in maintenance of HCC cells by regulating MKK6 binding and p38 MAPK signaling. REX1 deficiency induced enhancement of p38 MAPK signaling, leading to F‐actin reorganization and activation of nuclear factor erythroid 2‐related factor 2–mediated oxidative stress response, which collectively contributed to enhanced stemness and metastatic capabilities of HCC cells.
Developing your career as a physician in general internal medicine
Authors: Jacqui Wise
Journal: BMJ (2019)

A career in general internal medicine is varied, challenging, and rewarding. Doctors in the specialty manage a wide range of acute and long term medical conditions and symptoms. They are experts in diagnostic reasoning, dealing with uncertainty, and managing comorbidities. A career in general internal medicine also offers opportunities to subspecialise or to combine clinical work with academic research or a non-clinical role.

After completing the examinations for membership of the Royal College of Physicians, doctors move into specialty training which can take a further three to six years. Nearly all training in general internal medicine is done in parallel with another specialty, such as acute internal medicine, cardiology, clinical pharmacology and therapeutics, endocrinology and diabetes, gastroenterology, geriatric medicine, infectious diseases, renal medicine, respiratory medicine, or rheumatology.

To gain access to specialty training in general internal medicine it is necessary to apply for one of these …
Outcomes and Factors Impacting Use of Axicabtagene Ciloleucel in Refractory and Relapsed Large B-Cell Lymphoma: An Intent-to-Treat Analysis
Authors: Agrima Mian, Wei Wei, Allison M. Winter, Jack Khouri, Deepa Jagadeesh, Faiz Anwer, Aaron T. Gerds, Robert M. Dean, Ronald Sobecks, Brad Pohlman, Matt Kalaycio, Betty K. Hamilton, Navneet S. Majhail, Brian T. Hill
Journal: Blood (2019)
Review: After PCI with DESs, long- and standard-term DAPT increase some adverse outcomes vs short-term DAPT
Authors: Emilie Belley-Côté, John Eikelboom
Journal: Annals of Internal Medicine (2019)

Source Citation Yin SH, Xu P, Wang B, et al. Duration of dual antiplatelet therapy after percutaneous coronary intervention with drug-eluting stent: systematic review and network meta-analysis. BMJ. 2019;365:l2222. 31253632
STEM-15. RADIATION-INDUCED MODULATION OF NEURODEVELOPMENTAL PATHWAYS IN CLASSICAL GLIOMA STEM CELLS
Authors: Costanza Lo Cascio, Ernesto Luna Melendez, James McNamara, Robert Schultz, An-Chi Tien, Christopher Plaisier, Shwetal Mehta
Journal: Neuro-Oncology (2019)

Abstract The current standard-of-care treatment for GBM is ineffective and fails to significantly prolong survival. Following exposure to aggressive multimodal treatment, GBMs have been shown to frequently shift their biological features upon recurrence, acquiring a more resistant phenotype. However, the temporal dynamics and molecular mechanisms that facilitate GBM recurrence are poorly understood. The objective of our study was to assess the acute response to ionizing radiation in glioma stem cells (GSCs) from the Classical subtype of GBM in vitro and in vivo. We find that Classical GSCs rapidly undergo dramatic molecular and cellular changes in response to single and fractionated doses of ionizing radiation, resulting in a heterogeneous cell population. Ionizing radiation causes a transient decrease in the expression of key stemness genes (e.g., SOX2) followed by drastic morphological changes and a concomitant significant increase in the levels of key cell fate markers expressed in adult quiescent neural stem cells. Radiation-induced alteration of SOX2 levels in Classical GSCs is dependent on intact p53 signaling. GSCs previously exposed to radiation are more radio-resistant upon re-treatment compared to their naïve, untreated counterparts – suggesting that the aforementioned phenotypic shift to a quiescent neural stem cell phenotype promotes treatment resistance. Our results suggest that cell-intrinsic factors dictate how GSCs respond to radiation, and that Classical GSCs are neurodevelopmentally predisposed to shift towards an astrocytic/neural stem cell identity in response to cellular stress.
Domestication of High-Copy Transposons Underlays the Wheat Small RNA Response to an Obligate Pathogen
Authors: Manuel Poretti, Coraline Rosalie Praz, Lukas Meile, Carol Kälin, Luisa Katharina Schaefer, Michael Schläfli, Victoria Widrig, Andrea Sanchez-Vallet, Thomas Wicker, Salim Bourras
Journal: Molecular Biology and Evolution (2019)

Abstract Plant genomes have evolved several evolutionary mechanisms to tolerate and make use of transposable elements (TEs). Of these, transposon domestication into cis-regulatory and microRNA (miRNA) sequences is proposed to contribute to abiotic/biotic stress adaptation in plants. The wheat genome is derived at 85% from TEs, and contains thousands of miniature inverted-repeat transposable elements (MITEs), whose sequences are particularly prone for domestication into miRNA precursors. In this study, we investigate the contribution of TEs to the wheat small RNA immune response to the lineage-specific, obligate powdery mildew pathogen. We show that MITEs of the Mariner superfamily contribute the largest diversity of miRNAs to the wheat immune response. In particular, MITE precursors of miRNAs are wide-spread over the wheat genome, and highly conserved copies are found in the Lr34 and QPm.tut-4A mildew resistance loci. Our work suggests that transposon domestication is an important evolutionary force driving miRNA functional innovation in wheat immunity.
Abstract 16418: Diurnal Variation of Frequency Domain T Wave Alternans on 24-Hour Ambulatory Electrocardiogram in Subjects Without Heart Disease: Significant Effect of Autonomic Nervous Activity of the Heart
Authors: Bonpei Takase
Journal: Circulation (2018)

Background: T wave alternans (TWA) is a risk stratification predictor for fatal arrhythmia. However, little is known about the diurnal variation of TWA by frequency domain (FD) analysis. Whether TW...
Validation of the Plasmic Score for Predicting ADAMTS13 Activity &lt; 10% in Patients Admitted to Hospitals in Alberta with Suspected Thrombotic Thrombocytopenic Purpura
Authors: Chris Wynick, Joanne Britto, Daniel Sawler, Arabesque Parker, Mohammad Karkhaneh, Dawn Goodyear, Haowei Linda Sun
Journal: Blood (2019)
Next-Generation FVIII Mimetic Shows Superior Effect in a FIX- and Fx-Humanized Mouse Model In Vivo
Authors: Carsten Dan Ley, Thomas Lindebo Holm, Daniel Elenius, Heidi Lindgreen Holmberg, Jais Rose Bjelke, Mette Loftager, Mette B Hermit, Ida Hilden, Stine L Kjellev
Journal: Blood (2019)
Subcutaneous Alemtuzumab Has Activity in Treatment-Naïve Patients with Acquired Aplastic Anemia
Authors: Ana Rita Da Fonseca, Anita Hill, Patricia Eiko Yamakawa, Iara Baldim Rabelo, Andre Domingues Pereira, Vinicius Campos de Molla, Matheus Vescovi Gonçalves, Morag Griffin, Talha Munir, Peter Hillmen, Louise Arnold, Kathryn Riley, Antonio M. Risitano, Phillip Scheinberg, Celso Arrais-Rodrigues
Journal: Blood (2019)
DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation
Authors: Joel Zindel, Paul Kubes
Journal: Annual Review of Pathology Mechanisms of Disease (2019)

Recognizing the importance of leukocyte trafficking in inflammation led to some therapeutic breakthroughs. However, many inflammatory pathologies remain without specific therapy. This review discusses leukocytes in the context of sterile inflammation, a process caused by sterile (non-microbial) molecules, comprising damage-associated molecular patterns (DAMPs). DAMPs bind specific receptors to activate inflammation and start a highly optimized sequence of immune cell recruitment of neutrophils and monocytes to initiate effective tissue repair. When DAMPs are cleared, the recruited leukocytes change from a proinflammatory to a reparative program, a switch that is locally supervised by invariant natural killer T cells. In addition, neutrophils exit the inflammatory site and reverse transmigrate back to the bloodstream. Inflammation persists when the program switch or reverse transmigration fails, or when the coordinated leukocyte effort cannot clear the immunostimulatory molecules. The latter causes inappropriate leukocyte activation, a driver of many pathologies associated with poor lifestyle choices. We discuss lifestyle-associated inflammatory diseases and their corresponding immunostimulatory lifestyle-associated molecular patterns (LAMPs) and distinguish them from DAMPs.
Where Is Cannabis Legalization Leading?
Authors: Richard A. Grucza, Andrew D. Plunk
Journal: JAMA Psychiatry (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Mutated MYD88 Regulates HCK Pro-Survival Signaling through JunB in MYD88 Mutated B-Lymphoma Cells
Authors: Xia Liu, Jiaji G Chen, Manit Munshi, Lian Xu, Amanda Kofides, Nicholas Tsakmaklis, Maria Demos, Maria Luisa Guerrera, Gloria G Chan, Cristina Jimenez, Zachary R Hunter, Christopher Patterson, Kirsten Meid, Andrew Keezer, Jorge J. Castillo, Steven P Treon, Guang Yang
Journal: Blood (2019)
Perinatal Mortality Survey
Authors: T. L. T. Lewis
Journal: BMJ (1962)

CORRESPONDENCE BONALacid levels in four gouty patients with raised levels during two-weekly periods of treatment with triamterene in doses of 150 or 200 mg.daily, and have failed to show any consistent changes.A fifth patient with hyper- uricaemia due to polycythaemia showed no change in urinary uric acid excretion with a dose of 50 mg.daily.When this was increased to 200 mg.daily there was an initial rise in daily excretion from a control level of 275 mg. per 24 hours to 420 mg. on the second day of treatment, but it then fell to control levels despite continued treatment.-Weare, etc.,
Leukocyte function assessed via serial microlitre sampling of peripheral blood from sepsis patients correlates with disease severity
Authors: Bakr Jundi, Hyunryul Ryu, Do-Hyun Lee, Raja-Elie E. Abdulnour, Braden D. Engstrom, Melody G. Duvall, Angelica Higuera, Mayra Pinilla-Vera, Maura E. Benson, Jaemyon Lee, Nandini Krishnamoorthy, Rebecca M. Baron, Jongyoon Han, Joel Voldman, Bruce D. Levy
Journal: Nature Biomedical Engineering (2019)
The UK Experience of Renal Transplantation in AL Amyloidosis
Authors: Oliver C Cohen, Faye Sharpley, Julian Gillmore, Helen Lachmann, Shameem Mahmood, Sajitha Sachchithanantham, Carol Whelan, Ana Martinez De Azcona Naharro, Marianna Fontana, Philip Hawkins, Ashutosh D. Wechalekar
Journal: Blood (2019)
Telomere Elongation and Clinical Improvement in Telomeropathy Patients: A Prospective Clinical Trial of Nandrolone in Telomeropathies
Authors: Diego V Clé, Luiz Fernando Catto, Luiz Guilherme Darrigo, Elvis Valera, Fernanda Gutierrez-Rodrigues, Flavia S. Donaires, André Pinto, Renan C. Albino, Bárbara Santana, Jose Baddini-Martinez, Rodrigo T. Calado
Journal: Blood (2019)
Regional Intra-Arterial Steroid Treatment in 113 Patients with Steroid Resistant or Dependent Graft-Versus-Host Disease
Authors: Michael Y Shapira, Sheth Vipul, Alexander Klimov, Sigal Griesaro, Panagiotis Tsirigotis, Batia Ronit Avni, Reuven Or, Allan Bloom
Journal: Blood (2016)
Phase 1 Results of Anti-PD-Ligand 1 (Durvalumab) &amp; Lenalidomide in Patients with Cutaneous T Cell Lymphoma and Correlation with Programmed Death Ligand 1 Expression and Gene Expression Profile
Authors: Christiane Querfeld, Xiwei Wu, Tracy Stiller, Joycelynne Palmer, James F Sanchez, Xochiquetzal Martinez, Steven Rosen, Jasmine Zain
Journal: Blood (2019)
Acute Myeloid Leukemia (AML) with 9q Aberrations Occuring within a Non-Complex Karyotype Is Highly Associated with CEBPA and NPM1 Mutations - A Joint Analysis of the German-Austrian AML Study Group (AMLSG) and Cancer and Leukemia Group B (CALGB).
Authors: Andrea Corbacioglu, Stefan Fröhling, Peter Paschka, Guido Marcucci, Andreas Anhalt, Katja Urlbauer, Jürgen Krauter, Richard Larson, Krzysztof Mrózek, Amy S. Ruppert, Arnold Ganser, Michael A. Caligiuri, Hartmut Döhner, Richard F. Schlenk, Clara D. Bloomfield, Konstanze Döhner
Journal: Blood (2007)
CUL4B negatively regulates Toll-like receptor-triggered proinflammatory responses by repressing Pten transcription
Authors: Yu Song, Peishan Li, Liping Qin, Zhiliang Xu, Baichun Jiang, Chunhong Ma, Changshun Shao, Yaoqin Gong
Journal: Cellular and Molecular Immunology (2019)
NIMG-19. T1- AND T2-RELAXOMETRY FOR TISSUE CELL DENSITY QUANTIFICATION IN GLIOMA IMAGING: EXPLORATORY STUDY VIA 11C-METHIONINE PET AND VALIDATION VIA STEREOTACTIC TISSUE SAMPLING
Authors: Manabu Kinoshita, Masato Uchikoshi, Souichiro Tateishi, Shohei Miyazaki, Mio Sakai, Tomohiko Ozaki, Katsunori Asai, Yuya Fujita, Takahiro Matsuhashi, Yonehiro Kanemura, Eku Shimosegawa, Jun Hatazawa, Shinichi Nakatsuka, Haruhiko Kishima, Katsuyuki Nakanishi
Journal: Neuro-Oncology (2019)

Abstract Visualization of non-contrast-enhancing tumor lesions in glioma is one of the most crucial yet challenging issues for patients with this pathology. This study examined the hypothesis that quantitative T1- and T2-relaxometry could reflect glioma tumor load within the brain and could further be used for visualizing non-enhancing heavily tumor-loaded areas. Participants comprised patients with low- or high-grade glioma. Correlation between T1- or T2-relaxation time and 11C-methionine uptake as measured by positron emission tomography (Cohort-1) was investigated followed by comparing T1- or T2-relaxation time with tumor cell density as measured by stereotactic image-guided tissue sampling in a different cohort (Cohort-2). T1-relaxometry was achieved by converting Magnetization Prepared Rapid Gradient Echo (MP2RAGE) images and T2-relaxometry by multi-echo T2-weighted images via Bayesian inference modeling. T1-relaxation time &gt;2000 ms but &lt; 3200 ms or T2-relaxation time &gt;115 ms but &lt; 265 ms were indicative of high 11C-methionine uptake. Stereotactic tissue sampling study confirmed that tissue cell densities obtained from locations with a T1-relaxation time of 2000–3200 ms or a T2-relaxation time of 125–225 ms were significantly higher than those obtained from other locations (p &lt; 0.001 and p = 0.03, respectively). Synthetic tumor load images were successfully reconstructed using T1- and T2-relaxation mapping. T1- and T2-relaxation times both correlated well with tumor cell density in glioma tissues. The ideal ranges for identifying high tumor load tissues were 2000–3200 ms for T1-relaxation time and 115–220 ms for T2-relaxation both measured at 3.0 T.
Managing type 1 diabetes in the active population
Authors: Nicola Keay, Richard M Bracken
Journal: British Journal of Sports Medicine (2019)

Many high-profile athletes participate across a wide range of sports with type 1 diabetes. Team Type 1 encourages and supports those with type 1 diabetes to participate in physical activity, with professional cycling’s Team Novo Nordisk composed entirely of individuals with type 1 diabetes. Type 1 diabetes is likely to present early in an athlete’s career, a time when athletes may present with fatigue due to increased training loads. All physicians need to distinguish between possible causes of fatigue in these athletes.

Type 1 diabetes is an autoimmune condition with T-cell-mediated destruction of the pancreatic β cells of the islets of Langerhans, resulting in failure to produce sufficient insulin. The clinical outcome is an inability to adequately control glucose metabolism. Effective glucose metabolism is crucial in long-duration and high-intensity exercise. Self-administered exogenous insulin is required as a treatment to manage blood glucose.

The physiological response to exercise is a progressive decrease in insulin and increase in the pancreatic α-cell-derived antagonist hormone glucagon, while exercise also increases insulin sensitivity (increased ‘sensitivity’ means that for a given dose, there is a more pronounced effect—insulin does its job ‘better’). In addition, there is an exercise-induced rise in sympathoadrenal hormones …
DYRK1A Is Regulated By Oncogenic KMT2A and Required for Survival of KMT2A-Rearranged Acute Lymphoblastic Leukemia
Authors: Christian Hurtz, Gerald Wertheim, Rahul S. Bhansali, Anne Lehman, Grace Jeschke, John D. Crispino, Thierry Besson, Sarah K. Tasian, Martin Carroll
Journal: Blood (2019)
Profiling the Immune Tumor Microenvironment of Newly Diagnosed Diffuse Large B Cell Lymphoma Identifies Three Major Immune Infiltration Patterns
Authors: C. Chris Huang, Yumi Nakayama, Matthew Stokes, Fadi Towfic, chung-Wein Lee, Yan Ren, Mathieu Marella, Maria Wang, Patrick R. Hagner, Suzana Couto, Kathryn Newhall, Anita K Gandhi
Journal: Blood (2019)
Modulating the tumor microenvironment with new therapeutic nanoparticles: A promising paradigm for tumor treatment
Authors: Yinlong Zhang, Shih‐Hsin Ho, Bozhao Li, Guangjun Nie, Suping Li
Journal: Medicinal Research Reviews (2019)

Abstract To better make nanomedicine entering the clinic, developing new rationally designed nanotherapeutics with a deeper understanding of tumor biology is required. The tumor microenvironment is similar to the inflammatory response in a healing wound, the milieu of which promotes tumor cell invasion and metastasis. Successful targeting of the microenvironmental components with effective nanotherapeutics to modulate the tumor microvessels or restore the homeostatic mechanisms in the tumor stroma will offer new hope for cancer treatment. We here highlight the progress in constructing nanotherapeutics to target or modulate the tumor microenvironment. We discuss the factors necessary for nanomedicines to become a new paradigm in cancer therapy, including the selection of drugs and therapeutic targets, controllable synthesis, and tempo‐spatial drug release.
The Effect of Apoptosis Inhibitor Blockade Agents on the Third Generation CD19 CAR T Cells
Authors: Mingya Yang, Lei Wang, Ming Ni, Maria-Luisa Schubert, Brigitte Neuber, Angela Hückelhoven-Krauss, Ruben A. Gößmann, Christian Kleist, Volker Eckstein, Carsten Müller-Tidow, Peter Dreger, Michael Schmitt, Anita Schmitt
Journal: Blood (2019)
Allogeneic Blood Stem Cell Transplantation in Patients with Hematologic Diseases after Conditioning with Treosulfan and Fludarabine.
Authors: Jochen Casper, Stefan Wilhelm, Beate Steiner, Daniel Wolff, Norbert Grobe, Detlev Haehling, Gernot Hartung, Inken Hilgendorf, Andreas Lueck, Christian Junghanss, Christoph Kahl, Uwe Pichlmeier, Mathias Freund
Journal: Blood (2005)
Metaphase Cytogenetics for Risk Stratification in Newly Diagnosed Multiple Myeloma
Authors: Patrick Mellors, Moritz Binder, Rhett P. Ketterling, Patricia Griepp, Linda B Baughn, Francis K. Buadi, Martha Q. Lacy, Morie A. Gertz, Angela Dispenzieri, Suzanne Haymann, Prashant Kapoor, Wilson I Gonsalves, Yi Lisa Hwa, Amie Fonder, Miriam A. Hobbs, Taxiarchis Kourelis, Rahma M Warsame, John A. Lust, Nelson Leung, Ronald S. Go, Robert A. Kyle, S. Vincent Rajkumar, Shaji K. Kumar
Journal: Blood (2019)
Pre-Diagnosis Plasma Immune Markers and Risk of Non-Hodgkin Lymphoma and Its Major Histologic Subtypes: A Prospective Analysis in Two Large Cohorts
Authors: Brenda M. Birmann, Mara M. Epstein, Elizabeth C. Breen, Kimberly A. Bertrand, Francine Laden, Bernard A. Rosner, Edward Giovannucci, Larry I. Magpantay, Otoniel Martinez-Maza
Journal: Blood (2014)