Symptom-based stratification of patients with primary Sjögren's syndrome: multi-dimensional characterisation of international observational cohorts and reanalyses of randomised clinical trials
Authors: Jessica R Tarn, Nadia Howard-Tripp, Dennis W Lendrem, Xavier Mariette, Alain Saraux, Valerie Devauchelle-Pensec, Raphaele Seror, Andrew J Skelton, Katherine James, Peter McMeekin, Shereen Al-Ali, Katie L Hackett, B Clare Lendrem, Ben Hargreaves, John Casement, Sheryl Mitchell, Simon J Bowman, Elizabeth Price, Colin T Pease, Paul Emery, Peter Lanyon, John Hunter, Monica Gupta, Michele Bombardieri, Nurhan Sutcliffe, Costantino Pitzalis, John McLaren, Annie Cooper, Marian Regan, Ian Giles, David Isenberg, Vadivelu Saravanan, David Coady, Bhaskar Dasgupta, Neil McHugh, Steven Young-Min, Robert Moots, Nagui Gendi, Mohammed Akil, Bridget Griffiths, Svein J A Johnsen, Katrine B Norheim, Roald Omdal, Deborah Stocken, Colin Everett, Catherine Fernandez, John D Isaacs, Jacques-Eric Gottenberg, Wan-Fai Ng, Valerie Devauchelle-Pensec, Philippe Dieude, Jean Jacques Dubost, Anne-Laure Fauchais, Vincent Goeb, Eric Hachulla, Claire Larroche, Véronique Le Guern, Jacques Morel, Aleth Perdriger, Xavier Puéchal, Stephanie Rist, Damien Sen, Jean Sibilia, Olivier Vittecoq, Joelle Benessiano, Sarah Tubiana, Karine Inamo, Stanie Gaete, Djilali Batouche, Domitille Molinari, Mickael Randrianandrasana, Isabelle Pane, Adeline Abbe, Gabriel Baron, Philippe Ravaud, Jacques-Eric Gottenberg, Philippe Ravaud, Xavier Puéchal, Véronique Le Guern, Jean Sibilia, Claire Larroche, Alain Saraux, Valérie Devauchelle-Pensec, Jacques Morel, Gilles Hayem, Pierre Hatron, Aleth Perdriger, Damien Sene, Charles Zarnitsky, Djilali Batouche, Valérie Furlan, Joelle Benessiano, Elodie Perrodeau, Raphaele Seror, Xavier Mariette, S Brown, N Coy Navarro, C Pitzalis, P Emery, S Pavitt, J Gray, C Hulme, F Hall, R Busch, P Smith, L Dawson, M Bombardieri, W-F Ng, C Pease, E Price, N Sutcliffe, C Woods, S Ruddock, C Everett, C Reynolds, E Skinner, A Poveda-Gallego, J Rout, I Macleod, S Rauz, S Bowman, Wan-Fai Ng, Simon J Bowman, Bridget Griffiths, Frances Hall, Elalaine C Bacaba, Helen Frankland, Robert Moots, Kuntal Chadravarty, Shamin Lamabadusuriya, Michele Bombardieri, Constantino Pitzalis, Nurhan Sutcliffe, Celia Breston, Nagui Gendi, Karen Culfear, Claire Riddell, John Hamburger, Andrea Richards, Saaeh Rauz, Sue Brailsford, Joanne Dasgin, Joanne Logan, Diarmuid Mulherin, Jacqueline Andrews, Pau Emery, Alison McManus, Colin Pease, David Pickles, Alison Booth, Marian Regan, Jon King Kin, Amanda Holt, Theodoros Dimitroulas, Lucy Kadiki, Daljit Kaur, George Kitas, Abdul Khan, Tracey Cosier, None Panthakalam, Kell Mintrim, Mark Lloyd, Lisa Moore, Esther Gordon, Cathy Lawson, Monica Gupta, John Hunter, Lesley Stirton, Gill Ortiz, Elizabeth Price, Suzannah Pelger, Claire Gorman, Balinder Hans, Gavin Clunie, Suzanne Lane, Ginny Rose, Sue Cuckow, Michael Batley, Ruby Einosas, Susan Knight, Deborah Symmons, Beverley Jones, Andrew Carr, Suzanne Edgar, Francisco Figuereido, Heather Foggo, Dennis Lendrem, Iain Macleod, Sheryl Mitchell, Christine Downie, Jessica Tarn, James Locke, Shereen Al-Ali, Sarah Legg, Kamran Mirza, Ben Hargreaves, Laura Hetherington, Adrian Jones, Peter Lanyon, Alice Muir, Paula White, Steven Young-Min, Susan Pugmire, Saravanan Vadivelu, Annie Cooper, Marianne Watkins, Anne Field, Stephen Kaye, Devesh Mewar, Patricia Medcalf, Pamela Tomlinson, Debbie Whiteside, Neil McHugh, John Pauling, Julie James, Andrea Dowden, Mohammed Akil, Jayne McDermott, Olivia Godia, David Coady, Elizabeth Kidd, Lynne Palmer, Charles Li, Sarah Bartrum, De Mead, Bhaskar Dasgupta, Victoria Katsande, Pamela Long, Erin Vermaak, Janet Turner, Usha Chandra, Kirsten MacKay, Stefano Fedele, Ada Ferenkeh-Koroma, Ian Giles, David Isenberg, Helena MaConnell, Nyarko Ahwiren, Stephen Porter, Paul Allcoa, John McLaren
Journal: The Lancet Rheumatology (2019)

Heterogeneity is a major obstacle to developing effective treatments for patients with primary Sjögren's syndrome. We aimed to develop a robust method for stratification, exploiting heterogeneity in patient-reported symptoms, and to relate these differences to pathobiology and therapeutic response.