tbuckley/cabot-search huggingface dataset:
PB1804 OUTCOME OF AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION IN FIRST COMPLETE REMISSION IN PATIENTS WITH LOW‐RISK PERIPHERAL T‐CELL LYMPHOMAS (PTCLS)
Authors: H. Huang, S. Liu, X. Chen, Z. Jin, D. Wu
Journal: HemaSphere (2019)

Background: Patients with peripheral T cell lymphomas (PTCLs) generally have a poor prognosis with conventional chemotherapy. Consolidation with autologous stem cell transplantation is an option for patients with PTCL. However, whether prospective or retrospective studies on the timing of autologous stem cell transplantation remains controversial. We cannot determine whether autologous stem cell transplantation is necessary in patients with PTCL achieving first complete remission (CR1) following induction chemotherapy, especially in patients with low‐risk group. Therefore, we compare prognosis of low‐risk patients who underwent ASCT in CR1 following induction regimens and patients who underwent observation and waiting during CR1. Aims: We compare progression‐free survival of low‐risk patients who underwent ASCT in CR1 following induction regimens and patients who underwent observation and waiting during CR1. Methods: We completed a retrospective analysis for low‐risk PTCL patients who underwent either observation or up‐front ASCT during CR1 in our center between 1/1/2007 and 12/31/2018. In our study, patients with PTCL age ≤65 years(median age, 52 years) and IPI score 0‐1 were included. Histologic subtypes include PTCL not otherwise specified (PTCL‐NOS), angioimmunoblastic T‐cell lymphoma a(AITL) and anaplastic lymphoma kinase‐negative large cell lymphoma (ALK‐negative ALCL). In addition, patients with cutaneous T cell lymphoma and anaplastic lymphoma kinase‐positive large cell lymphoma (ALK‐positive ALCL) were excluded. The probabilities of PFS was calculated by the Kaplan‐Meier method and compared by a log‐rank test. The estimated lymphoma of relapse was calculated using cumulative incidence. Results: In our center, 42 patients met all inclusion and exclusion criteria. And 29 patients underwent observation and waiting in CR1, 13 patients underwent consolidative ASCT. In low‐risk patients of PTCL, with a median follow‐up of 22 months, estimated 2‐year PFS and 5‐year PFS in the observation group were 57.4% and 46.0%, respectively. Among ASCT recipients, the 2‐year and 5‐year PFS were 67.7% and 54.2%, respectively. When considering incidence of disease relapse, the 1‐year cumulative incidence of relapse in the observation and ASCT groups was 20.3% and 32.3%, respectively. However, there were no difference between observation and ASCT groups. Summary/Conclusion: In conclusion, for low‐risk PTCL patients achieving CR1 following induction therapy, consolidative ASCT does not extend progression‐free survival compared to observation. We favor proceeding to observe and wait because of high toxic of hematopoietic stem cell transplantation. image
Abstract 19986: Cyclic Stretch-induced CRP3/MLP Sensitizes Vascular Smooth Muscle Cells to Apoptosis During Vein Remodeling in Response to Arterialization
Authors: Luciana C Campos, Alessandra S Menegon, Valerio Barauna, Pamela R Mautan, Ayumi A Miyakawa, Jose Krieger
Journal: Circulation (2014)

Introduction: We have demonstrated stretch-induced up-regulation of cysteine- and glycine-rich protein 3/muscle LIM-domain protein (CRP3/MLP) rat and human saphenous veins in response to arterialization. Hypothesis: We developed a KO rat to test the hypothesis that CRP3/MLP is a key modifier of vein remodeling during arterialization. Methods/Results: Under basal conditions, we found no micro-macroscopic gross abnormalities in conduit arterial/vein vessels in KO rats. Upon arterialization of jugular vein for 28 days, CRP3 KO compared to WT rats showed a 3-fold increase of intima layer (Area 103 μm2 - CRP3 KO: 250.9 ± 80.0, WT: 79.7 ± 32.3) and inhibition of early apoptotic event (TUNEL positive cells - CRP3 KO: 0.4 ± 0.7, WT: 30.6 ± 6.8). To gain insight on the increased remodeling response, we investigated CRP3 role on apoptosis. Interestingly, ceramide-induced apoptosis was restricted to the presence of basal CRP3 expression. Aortic SMCs, with endogenous CRP3 expression, displayed increased apoptosis compared to cells from KO rats (% of dead cells - CTRL - CRP3 KO: 1.8 ± 0.3, WT: 8.3 ± 1.7; Ceramide 100μm- CRP3 KO: 12.4 ± 7.3, WT: 54.8 ± 8.3). Ceramide failed to induce apoptosis in the absence of CRP3 expression in both jugular vein SMC KO and WT under basal conditions. Upon stretch, WT vein SMC displayed increased CRP3 expression (CRP3/GAPDH gene expression -Static: 0; Stretched: 0.4 ± 0.05) that was accompanied by ceramide-induced apoptosis (% of dead cells - Static control: 0.5 ± 0.1; Static ceramide: 0.8 ± 0.1; Stretched control: 0.7 ± 0.6; Stretched ceramide: 11.4 ± 0.1). Similarly, ceramide-induced apoptosis decreased in stretched CRP3-KO jugular (% of dead cells - Static control: 0.4 ± 0.06; Static ceramide: 0.8 ± 0.07; Stretched control: 0.4 ± 0.2; Stretched ceramide: 0.9 ± 0.06). Western blot analysis showed that ceramide stretch-induced apoptosis in SMC is accompanied by decreased pFAK and pAKT, which may lead Bax to translocate to mitochondria, resulting in caspase 3 activation. Conclusion: Taken together, we provide evidence that CRP3/MLP influences vein remodeling in response to arterialization by sensitizing cells to stretch-induced apoptosis.
Preexposure Prophylaxis for the Prevention of HIV Infection
Authors: Roger Chou, Christopher Evans, Adam Hoverman, Christina Sun, Tracy Dana, Christina Bougatsos, Sara Grusing, P. Todd Korthuis
Journal: JAMA (2019)

Effective prevention strategies for HIV infection are an important public health priority. Preexposure prophylaxis (PrEP) involves use of antiretroviral therapy (ART) daily or before and after sex to decrease risk of acquiring HIV infection.To synthesize the evidence on the benefits and harms of PrEP, instruments for predicting incident HIV infection, and PrEP adherence to inform the US Preventive Services Task Force.Ovid MEDLINE, the Cochrane Central Register of Controlled Trials, the Cochrane Database of Systematic Reviews, and EMBASE through June 2018, with surveillance through January 2019.English-language placebo-controlled randomized clinical trials of oral PrEP with tenofovir disoproxil fumarate/emtricitabine or tenofovir disoproxil fumarate monotherapy; studies on the diagnostic accuracy of instruments for predicting incident HIV infection; and studies on PrEP adherence.Dual review of titles and abstracts, full-text articles, study quality, and data abstraction. Data were pooled using the Dersimonian and Laird random-effects model for effects of PrEP on HIV infection, mortality, and harms.HIV acquisition, mortality, and harms; adherence to PrEP; and diagnostic test accuracy and discrimination.Fourteen RCTs (N = 18 837), 8 observational studies (N = 3884), and 7 studies of diagnostic accuracy (N = 32 279) were included. PrEP was associated with decreased risk of HIV infection vs placebo or no PrEP after 4 months to 4 years (11 trials; relative risk [RR], 0.46 [95% CI, 0.33-0.66]; I2 = 67%; absolute risk reduction [ARD], -2.0% [95% CI, -2.8% to -1.2%]). Greater adherence was associated with greater efficacy (RR with adherence ≥70%, 0.27 [95% CI, 0.19-0.39]; I2 = 0%) in 6 trials. PrEP was associated with an increased risk of renal adverse events (12 trials; RR, 1.43 [95% CI, 1.18-1.75]; I2 = 0%; ARD, 0.56% [95% CI, 0.09%-1.04%]) and gastrointestinal adverse events (12 trials; RR, 1.63 [95% CI, 1.26-2.11]; I2 = 43%; ARD, 1.95% [95% CI, 0.48%-3.43%]); most adverse events were mild and reversible. Instruments for predicting incident HIV infection had moderate discrimination (area under the receiver operating characteristic curve, 0.49-0.72) and require further validation. Adherence to PrEP in the United States in men who have sex with men varied widely (22%-90%).In adults at increased risk of HIV infection, PrEP with oral tenofovir disoproxil fumarate monotherapy or tenofovir disoproxil fumarate/emtricitabine was associated with decreased risk of acquiring HIV infection compared with placebo or no PrEP, although effectiveness decreased with suboptimal adherence.
MnFe2O4 nanoparticles accelerate the clearance of mutant huntingtin selectively through ubiquitin-proteasome system
Authors: Li Zhang, Peng-Fei Wei, Yong-Hong Song, Liang Dong, Ya-Dong Wu, Zong-Yao Hao, Song Fan, Sheng Tai, Jia-Lin Meng, Yang Lu, Jingzhe Xue, Chao-Zhao Liang, Long-Ping Wen
Journal: Biomaterials (2019)
AB0902 RHEUMATIC LYME DISEASE SYMPTOMS BASED ON EPIDEMIOLOGICAL DATA IN HIGH ENDEMIC EUROPE AREA
Authors: Agnė Petrulionienė, Daiva Radzišauskienė, Arvydas Ambrozaitis, Saulius Čaplinskas, Algimantas Paulauskas, Algirdas Venalis
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> Lyme disease is a tick born infectious disease caused by different genospecies of Borrelia bacteria (B. burgdorferi sensu strictu (ss), B. afzelii and B. garinii). The signs and symptoms of Lyme disease vary, they usually appear in stages, but the stages can overlap. In early stage skin rash (erythema migrans) appears, which may be accompanied by fever, chills, fatigue, body aches, headache, neck stiffness, and swollen lymph nodes. Later signs and symptoms can be these: joint pain and inflammation, neurological problems or other less common syndromes - heart problems, eye inflammation, and liver inflammation. Lyme disease is very common disease in the world, approximately 300,000 people get Lyme disease each year in the United States (Centers for disease control and prevention US), in Lithuania disease frequency is 101.6 cases per 100 000 population (Center for Communicable Diseases and AIDS, Lithuania, 2016 year). <h3>Objectives</h3> To investigate the frequency of rheumatic symptoms between Lyme diagnosed persons in Lithuania, based on epidemiological data. <h3>Methods</h3> We have analyzed data of Center for Communicable Diseases and Aids of Lithuania about Lyme diagnosed patients from 2014 to 2016 years. <h3>Results</h3> Total number of cases was 7425. 2791 males, 4633 females, age range 1 - 91 years, median age 52 years. 996 patients found out as symptomatic. The rest were either asymptomatic either information about clinical disease manifestation was not known. Among symptomatic patients two rheumatic symptoms were observed: arthralgia (220 cases, 22,1%), 140 females, 80 males, age range 12 – 84 years, median age 58 years, and myalgia (78 cases, 7,8%), 44 females, 34 males, age range 15-80, median age 56. Other symptoms were erythema migrans (75.6%), headache (15.2%), general weakness (12.4%), fever (10, 1%), and head dizziness (6.4%). <h3>Conclusion</h3> In total, almost 30 percentages (29, 91%) of symptoms were rheumatic. To conclude, joint pain and/or muscle pain can lead not only to systemic rheumatic diseases, but to infection diseases as well (for example: Lyme disease). <h3>References</h3> [1] Sergamumo užkrečiamomis ligomis Lietuvoje apžvalga 2016. Užkrečiamų ligų ir AIDS centras. 96-98 pages. http://www.ulac.lt/uploads/downloads/leidiniai/Sergamumo_apzvalga_2016.pdf [2] Franc Strle, Gary P. Wormser, Linden T. Hu, John A. Branda, Joppe W. R. Hovius, Xin Li, and Paul S. Mead. Lyme borreliosis. Nat Rev Dis Primers. 2017 Aug 3;3:17062. doi: 10.1038/nrdp.2017.62. [3] Lyme disease: summary of NICE guidance. BMJ2018;361:k1261. [4] Clinical spectrum of Lyme disease. Cardenas-de la Garza, J.A., De la Cruz-Valadez, E., Ocampo-Candiani, J. et al. Eur J Clin Microbiol Infect Dis (2018). https://doi.org/10.1007/s10096-018-3417-1 <h3>Disclosure of Interests</h3> None declared
Setting goals can help people with early stage dementia improve function
Authors: Rob Cook, Tara Lamont, Rosie Martin
Journal: BMJ (2019)

The studyClare L, Kudlicka A, Oyebode J R, et al. Goal-oriented cognitive rehabilitation for early-stage Alzheimer's and related dementias: the GREAT RCT. Health Technol Assess 2019;23:1-242.The trial was funded by the NIHR Health Technology Assessment Programme (project number11/15/04).To read the full NIHR Signal, go to: https://discover.dc.nihr.ac.uk/content/signal-000767/goal-setting-in-early-stage-dementia-can-improve-function.
DeepCpG: accurate prediction of single-cell DNA methylation states using deep learning
Authors: Christof Angermueller, Heather J. Lee, Wolf Reik, Oliver Stegle
Journal: Genome biology (2017)

Recent technological advances have enabled DNA methylation to be assayed at single-cell resolution. However, current protocols are limited by incomplete CpG coverage and hence methods to predict missing methylation states are critical to enable genome-wide analyses. We report DeepCpG, a computational approach based on deep neural networks to predict methylation states in single cells. We evaluate DeepCpG on single-cell methylation data from five cell types generated using alternative sequencing protocols. DeepCpG yields substantially more accurate predictions than previous methods. Additionally, we show that the model parameters can be interpreted, thereby providing insights into how sequence composition affects methylation variability.
Abstract 21008: Effects of Coronary Artery Revascularization With Biofreedom Stent Before Elective Surgery
Authors: Kyu Kim, Ji Yong Jang, Ae-Young Her, Sung-Jin Hong, Chul Min Ahn, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeon-Ki Hong, Yangsoo Jang, Byeong-Keuk Kim
Journal: Circulation (2017)

Introduction: The role of Biofreedom (polymer-free drug coated) stenting compared to coronary artery bypass graft (CABG) for coronary artery revascularization before elective surgery is unclear. Hypothesis: Biofreedom stent might be associated with better outcomes than CABG. Methods: Between January 2016 and Mar 2017, a total of 21 patients underwent percutaneous coronary intervention with Biofreedom stents before elective surgery (Biofreedom group) and 19 patients underwent CABG in the retrospective, multicenter cohort and we compared clinical outcomes between the Biofreedom group and CABG group. Primary outcomes were the period of planned operation after revascularization and the occurrence of the composite clinical endpoints (including death from any causes, myocardial infarction, stent thrombosis, stroke, any revascularization, or major bleeding). Results: During follow-up (mean 276.2± 134.3 days), all patients of Biofreedom group underwent planned surgery without delay, but 73.7% of patients in CABG group underwent surgery (p=0.04). Comparing the time to planned surgery, the Biofreedom group showed a greater incidence of performing surgery within 45 days than with CABG (72.7 vs. 31.6%, p=0.02). The Biofreedom group maintained a shorter duration of dual antiplatelet therapy (DAPT) (32.0 ± 10.0 vs 97.8 ± 88.3, p=0.005). During the entire treatment period, incidence of major bleeding after revascularization was significantly lower in Biofreedom group than CABG group (0% vs. 36.8%, p=0.007). There were no occurrence of death or stent thrombosis in the Biofreedom group. The Biofreedom group showed a significantly lower occurrence of primary outcome (7.2% versus 54.8%, HR 0.11, 95% CI 0.01 to 0.93, p=0.01, mainly due to the lower incidence of major bleeding after intervention). However, the statistical significance was not reached when only the perioperative period was observed. Conclusions: Biofreedom stent was associated with higher rate of performing planned surgery, shorter DAPT duration and lower incidence of major bleeding without increasing the risks of major cardiac event after surgery. In patients requiring coronary artery revascularization prior to elective surgery, Biofreedom stent might be a good treatment option.
AB0313 THE PREDICTORS OF UNDIAGNOSED DYSGLYCAEMIA IN PATIENTSWITH ESTABLISHED RHEUMATOID ARTHRITIS
Authors: Hazlyna Baharuddin, Nur Aini Eddy Warman, Azmillah Rosman, Thuhairah Abdul Rahman, Nurhuda Ismail, Rohana Abdul Ghani
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> Rheumatoid arthritis (RA) is a chronic inflammatory disease with an increased risk of diabetes and insulin resistance.<sup>1, 2</sup> The prevalence of type 2 diabetes mellitus (T2DM) were demonstrated to be 10.4% as compared to only 7.6% in 1:4 controls matched for age, sex and geographical region, with an odds ratio of 1.4.<sup>3</sup> <h3>Objectives</h3> To determine the prevalence of dysglycaemia (T2DM, impaired fasting glucose (IFG) and impaired glucose tolerance (IGT)) and the factors associated with dysglycaemia in patients with established RA. <h3>Methods</h3> This is a cross-sectional study conducted in a rheumatology centre in Malaysia. Patients with established RA aged 30 years or more were included. Exclusion criteria were overlap syndrome, pre-existing diabetes or pre-diabetes, pregnant and within 6 weeks of post-partum period. An oral glucose tolerance test (OGTT) was performed for all patients. Comparison of various factors between dysglycaemia and normoglycaemia were analysed. Multivariate analysis was performed using logistic regression analysis to ascertain the true effects of significant factors found on univariate analysis. <h3>Results</h3> The mean age of patients was 57.2 ± 8.1 years and 87.7% were female. Of 155 patients included in this study, 55 (35.5%) were found to have dysglycaemia; 40 (72.7%) had IGT, 11 (20%) had T2DM, 3 had IFG and IGT (5.5%) and 1 had IFG (1.8%). Significant factors between dysglycaemia and normoglycaemia is tabulated in Table 1. The predictors of dysglycaemia were previous or current smoker (OR 4.28, 95% CI 1.02 – 17.90) and raised triglycerides (OR 3.29, 95% CI 1.29 – 8.37). <h3>Conclusion</h3> One third of 155 patients had dysglycaemia and majority had IGT. The predictors of dysglycaemia in patients with established RA aged 30 years and more, were previous or current smoker and raised triglycerides. <h3>References</h3> [1] Su C-C, Chen I-C, Young F-N, Lian I-B. Risk of diabetes in patients with rheumatoid arthritis: a 12-year retrospective cohort study. The Journal of rheumatology. 2013;40(9):1513-8. [2] Ursini F, Russo E, D'Angelo S, Arturi F, Hribal ML, D'Antona L, et al. Prevalence of undiagnosed diabetes in rheumatoid arthritis: an OGTT study. Medicine. 2016;95(7):e2552 [3] Han C, Robinson DW, Hackett MV, Paramore LC, Fraeman KH, Bala MV. Cardiovascular disease and risk factors in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. The Journal of rheumatology. 2006;33(11):2167-72. <h3>Acknowledgement</h3> We would like to thank the Rheumatology team in Hospital Selayang and the Director General of Ministry of Health Malaysia for allowing us to conduct this study in Hospital Selayang. <h3>Disclosure of Interests</h3> None declared
AB0553 STUDY OF ANXIETY AND DEPRESSION IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)
Authors: Marta Rojas-Giménez, Stack John, James Galloway, Natalia Mena-Vázquez, Clara Fuego-Varela, Antonio Fernandez-Nebro
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Objectives:</h3> To study the prevalence of anxiety and depression in a cohort of patients with SLE at King's College Hospital in London,as well as its relationship with characteristics of disease and treatments <h3>Methods:</h3> Cross-sectional study of a cohort of patients with SLE.All patients with SLE who had been included in the IMPARTs project(Integrating Mental and Physical healthcare:Research,Training and Services)were recruited between 2012-2016.All patients filled out the following questionnaires on a tablet device:PHQ9(Patient Health Questionnaire)(Scores of 10 or more have an sensitivity and specifity close to 90% for major depression) and GAD-7(7-item Generalized Anxiety Disorder)(Scores of 10 or more have an sensitivity and specifity close to 89% and 82% for GAD).Variables:demographic, duration of the disease(months)and the profile of autoantibodies.Previous history of depression or anxiety. SLEDAI,treatments,ESR, CPR,C3 and C4.Statistical analysis:descriptive, bivariate using T-Student and χ2. <h3>Results:</h3> A total of 129 patients with SLE were included. Clinical characteristics in Table 1. 38 patients (29.5%)had some degree of major depression and 27(20.9%)generalized anxiety disorder(Table 2).The prevalence of major depression was higher in patients with anti RO52(42.3%vs23.8%, p=0.06),with generalized anxiety (81.5%vs 15.7%,p&lt;0.001)and in patients with black(35.2%vs 17.1%,p=0.03).The prevalence of generalized anxiety was higher in smokers(35%vs18.3%,p=0.09),patients receiving antidepressant treatment(57.1%vs13.9%, p&lt;0.001)and patients taking azathioprine(36.8%vs18.2%,p=0.06).The prevalence of both major was higher in those who had higher fatigue and VAS higher(mean67.1s44.8 and 60.8vs32.3 in major depression, respectively; p&lt;0.001) (65.3 vs 48.1 and 60.74 vs 35.4 in generalized anxiety respectively, p&lt;0.001).The SLEDAI,ESR, duration of the disease and age were associated with generalized anxiety in a non-significant way.CRP,ESR and the duration of the disease were higher in patients with major depression <h3>Conclusion:</h3> The prevalence of anxiety and depression in our group of patients was high,both related, as well as with the perception of pain and fatigue.A correct assessment of these manifestations and early treatment could help improve the quality of life of patients <h3>Disclosure of Interests:</h3> None declared
A Library for Internists II
Authors: RICHARD ALLYN
Journal: Annals of Internal Medicine (1976)

The Literature of Medicine1 March 1976A Library for Internists IIRecommended by the American College of PhysiciansRICHARD ALLYN, M.D., F.A.C.P.RICHARD ALLYN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-3-346 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe american college of physicians has responded to numerous requests for a new version of the highly successful "A Library for Internists" published in August 1973 (1) and presents here a new and current comprehensive list of the books and journals judged to be most useful for internists. The survey is again based on the premise that recommendations made by many authorities in each field will be a more reliable guide to the most useful books and journals on that field than recommendations made by only a few persons (2, 3).Many of the basic principles having to do with...References1. ALLYNSTEARNS RN: A library for internists. Ann Intern Med 79:293-322, 1973 LinkGoogle Scholar2. BRANDON A: Selected list of books and journals for the small medical library. Bull Med Libr Assoc 63:149-172, 1975 MedlineGoogle Scholar3. WESTWENDERMAY KRR: Books in clinical practice 1971-1975. Postgrad Med 56:60-81, 1974 CrossrefMedlineGoogle Scholar4. STEARNSRATCLIFF NW: A core medical library for practitioners in community hospitals. N Engl J Med 280:474-480, 1969 CrossrefMedlineGoogle Scholar5. Committed Selection: Abridged Index Medicus (editorial). N Engl J Med 282:220-221, 1970 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Springfield, Illinois▸Dr. Allyn is Chairman, Subcommittee on A Library for Internists, American College of Physicians Medical Practice Committee, Philadelphia, Pennsylvania, and Clinical Professor of Medicine, Southern Illinois University School of Medicine, Springfield, Illinois. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA Library for Internists VII Recommendations from the American College of PhysiciansKenneth M. Ludmerer, MDA Library for Internists VI Recommendations from the American College of PhysiciansEdward J. Huth, M.D., EditorA Library for Internists V Recommended by the American College of PhysiciansC. S. LEWIS Jr., M.D.A Library for Internists IV Recommended by the American College of PhysiciansRICHARD ALLYN, M.D.A Library for Internists III Recommended by the American College of PhysiciansRICHARD ALLYN, M.D. 1 March 1976Volume 84, Issue 3Page: 346-348KeywordsData managementLibraries ePublished: 1 December 2008 Issue Published: 1 March 1976 PDF downloadLoading ...