tbuckley/cabot-search huggingface dataset:
TCT CONNECT-202 Diagnostic Accuracy of Novel Ultrasonic Flow Ratio in Identifying Hemodynamical Significance of Coronary Stenosis
Authors: Wei Yu, Toru Tanigaki, Daixin Ding, Peng Wu, Haiyan Du, Li Ling, Biao Huang, Guanyu Li, Wei Yang, Su Zhang, Munenori Okubo, Bo Xu, Hitoshi Matsuo, William Wijns, Shengxian Tu
Journal: Journal of the American College of Cardiology (2020)
PTU-097 Long-term effect of obeticholic acid on transient elastography and ast to platelet ratio index in patients with pbc
Authors: GM Hirschfield, A Floreani, PJ Trivedi, R Pencek, A Liberman, T Marmon, L MacConell
Journal: Gut (2017)

Introduction  The AST to Platelet ratio (APRI) and transient elastography (TE) have both been identified as being predictive of adverse outcomes in primary biliary cholangitis (PBC). Obeticholic acid (OCA) is a farnesoid X receptor (FXR) agonist indicated for the treatment of PBC in combination with ursodeoxycholic acid (UDCA) in adults with an inadequate response to UDCA, or as monotherapy in adults unable to tolerate UDCA. Using the randomised, double-blind (DB), placebo (PBO)-controlled Phase 3 study investigating OCA in patients with PBC, along with data from the ongoing open-label extension (OLE) we sought to investigate the effects of OCA on established non-invasive measures of liver fibrosis and outcomes in PBC.  Method  We re-evaluated patients randomised and dosed in OCA 10 mg (n=73), OCA 5–10 mg (n=70, 33 patients titrated from 5 to 10 mg at Month 6), or PBO (n=73) groups during DB treatment. In the OLE, all patients were initially treated with 5 mg OCA with the option to increase to 10 mg (or later decrease) based on response and tolerability every 3 months. Non-invasive measures of liver fibrosis that were assessed were APRI and liver stiffness measurements (LSM) by transient elastography.  Results  APRI was significantly reduced from baseline to DB Month 12 in both OCA–treated groups compared to PBO (p  Conclusion  Both LSM and APRI, as non-invasive measures of liver fibrosis, have been found to be effective in predicting outcome in patients with PBC. DB and OLE treatment with OCA resulted in a mean reduction in liver stiffness and significant improvements in APRI suggesting that with long-term use, OCA has the potential to improve long term outcomes for patients.  Disclosure of Interest  G Hirschfield: None Declared, A Floreani: None Declared, P Trivedi: None Declared, R Pencek Conflict with: Intercept Pharmaceuticals, Inc., Conflict with: Intercept Pharmaceuticals, Inc., A Liberman Conflict with: Intercept Pharmaceuticals, Inc., Conflict with: Intercept Pharmaceuticals, Inc., T Marmon Conflict with: Intercept Pharmaceuticals, Inc., Conflict with: Intercept Pharmaceuticals, Inc., L MacConell Conflict with: Intercept Pharmaceuticals, Inc., Conflict with: Intercept Pharmaceuticals, Inc.
TCT CONNECT-451 Novel Conformable Foam-Based Implant for Left Atrial Appendage Closure: Conformal EFS Experience
Authors: Robert Sommer, Jamie Kim, Molly Szerlip, Mustafa Dohadwala, Sheetal Chandhok, Lissa Sugeng, Chris Cain, Aaron Kaplan, William Gray
Journal: Journal of the American College of Cardiology (2020)
Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia
Authors: Gun-Hoo Park, Haneul Noh, Zhicheng Shao, Peiyan Ni, Yiren Qin, Dongxin Liu, Cameron P. Beaudreault, Joy S. Park, Chiderah P. Abani, James M. Park, Derek T. Le, Sasha Z. Gonzalez, Youxin Guan, Bruce M. Cohen, Donna L. McPhie, Joseph T. Coyle, Thomas A. Lanz, Hualin S. Xi, Changhong Yin, Weihua Huang, Hae-Young Kim, Sangmi Chung
Journal: Nature Neuroscience (2020)
TCT CONNECT-419 Patients With Resistant Hypertension in the Global SYMPLICITY Registry: Antihypertensive Medication Burden and Changes in Blood Pressure out to 3 Years
Authors: Markus Schlaich, Michael Böhm, Giuseppe Mancia, Roland Schmieder, Krzysztof Narkiewicz, Luis Ruilope, Bryan Williams, Cheryl Shen, Felix Mahfoud
Journal: Journal of the American College of Cardiology (2020)
TCT CONNECT-120 Commissural Alignment After Balloon-Expandable TAVR Is Associated With Improved Hemodynamic Outcomes
Authors: Matthias Raschpichler, Nir Flint, Sung-Han Yoon, Chinar Patel, Chetana Singh, Vivek Patel, Michael Borger, Tarun Chakravarty, Raj Makkar
Journal: Journal of the American College of Cardiology (2020)
TCT CONNECT-307 Long-Term Outcomes After Coronary Intervention With Drug Eluting Stents for Unprotected Left Main Coronary Artery Stenosis According to Diabetes Mellitus Status
Authors: Anastasios Roumeliotis, David Power, Adam Reisman, Samantha Sartori, Davide Cao, Zhongjie Zhang, Mauro Chiarito, Rishi Chandiramani, Johny Nicolas, Ridhima Goel, Bimmer Claessen, Joseph Sweeny, George Dangas, Roxana Mehran, Annapoorna Kini, Samin Sharma
Journal: Journal of the American College of Cardiology (2020)
Altered FDG Biodistribution in Subcutaneous White Fat on PET/CT Following l-Asparaginase Chemotherapy
Authors: Colin R. Young, Michal E. Kulon, Anne Marie Boustani, Darko Pucar
Journal: Clinical Nuclear Medicine (2020)

A 13-year-old boy with mediastinal T-cell lymphoblastic lymphoma demonstrated an altered biodistribution with diffuse activity in subcutaneous white adipose tissue and decreased visceral activity on interim posttreatment FDG PET/CT. This altered biodistribution was attributed to administration of the chemotherapeutic enzyme l-asparaginase 3 hours preceding the PET/CT, altering adipocytes amino acid and glucose metabolism. Treatment response assessment was adversely affected by the altered biodistribution, emphasizing the importance of maximizing the time between chemotherapy and PET/CT during successive oncologic treatment cycles. Because adipocytes protect leukemic cells in culture from l-asparaginase, we hypothesize that white adipose tissue-altered biodistribution may be related to l-asparaginase resistance.
Toward allele-specific targeting therapy and pharmacodynamic marker for spinocerebellar ataxia type 3
Authors: Mercedes Prudencio, Hector Garcia-Moreno, Karen R. Jansen-West, Rana Hanna AL-Shaikh, Tania F. Gendron, Michael G. Heckman, Matthew R. Spiegel, Yari Carlomagno, Lillian M. Daughrity, Yuping Song, Judith A. Dunmore, Natalie Byron, Björn Oskarsson, Katharine A. Nicholson, Nathan P. Staff, Sorina Gorcenco, Andreas Puschmann, João Lemos, Cristina Januário, Mark S. LeDoux, Joseph H. Friedman, James Polke, Robin Labrum, Vikram Shakkottai, Hayley S. McLoughlin, Henry L. Paulson, Takuya Konno, Osamu Onodera, Takeshi Ikeuchi, Mari Tada, Akiyoshi Kakita, John D. Fryer, Christin Karremo, Inês Gomes, John N. Caviness, Mark R. Pittelkow, Jan Aasly, Ronald F. Pfeiffer, Venka Veerappan, Eric R. Eggenberger, William D. Freeman, Josephine F. Huang, Ryan J. Uitti, Klaas J. Wierenga, Iris V. Marin Collazo, Philip W. Tipton, Jay A. van Gerpen, Marka van Blitterswijk, Guojun Bu, Zbigniew K. Wszolek, Paola Giunti, Leonard Petrucelli
Journal: Science Translational Medicine (2020)

PolyQ ATXN3 is a pharmacodynamic marker for SCA3, and a SNP associated with the expanded allele may serve to specifically target mutant ATXN3 .
TCT CONNECT-447 Intracardiac Versus Transesophageal Echocardiography for Left Atrial Appendage Occlusion: An Updated Meta-analysis
Authors: Abdullah Al-Abcha, Mark Terence Mujer, Lawrenshey Charles, Manel Boumegouas, Tyler Kemnic, Yehia Saleh
Journal: Journal of the American College of Cardiology (2020)
TCT CONNECT-278 Prevalence and Anatomical Factors Associated to Vascular Remodeling Following Bioresorbable Scaffold Implantation
Authors: Tatsuhiro Fujimura, Mitsuaki Matsumura, Alaide Chieffo-dupe, Marco Ferrone, Antonio Colombo, Gary Mintz, Juan Granada, Akiko Maehara
Journal: Journal of the American College of Cardiology (2020)
Second primary cutaneous melanoma in patients with advanced melanoma treated with anti‐programmed‐death‐receptor‐1 monoclonal antibodies
Authors: E. Charvet, N. Kramkimel, L. Chaplain, A. Gantzer, O. Kassem, C. Longvert, A. Blom, N. Dupin, S. Aractingi, M. Hamon, U. Zimmermann, J.‐F. Emile, P. Sohier, T. Sidibé, P. Saiag, E. Funck‐Brentano
Journal: British Journal of Dermatology (2020)
TCT CONNECT-360 Percutaneous Mitral Valve Edge-to-Edge Repair in Patients With Failed Mitral Annuloplasty Rings
Authors: Divya Ratan Verma, Thomas Waggoner, Tony Gaidici, Marium Muzaffar, Edward Distler, Emrie Tomaiko, Camelle Jones, Ligita Centorino, Timothy Byrne, George Gellert, Arshad Banday, Samuel Unzek, Srikanth Seethala, Aneesh Kalya, Bani Khurana, Sarah Bertram, Deepti Taneja, Rajkumar Sugumaran, Kwan Lee, Mark Goldberg, Samuel Butman, David Biglari, Radha Gopalan, Hursh Naik, Kenith Fang
Journal: Journal of the American College of Cardiology (2020)
Consensus treatment recommendations from the tenth International Workshop for Waldenström Macroglobulinaemia
Authors: Jorge J Castillo, Ranjana H Advani, Andrew R Branagan, Christian Buske, Meletios A Dimopoulos, Shirley D'Sa, Marie José Kersten, Veronique Leblond, Monique C Minnema, Roger G Owen, M Lia Palomba, Dipti Talaulikar, Alessandra Tedeschi, Judith Trotman, Marzia Varettoni, Josephine M Vos, Steven P Treon, Efstathios Kastritis
Journal: The Lancet Haematology (2020)
TCT CONNECT-229 Predicting Technical Success of Chronic Total Occlusion Percutaneous Coronary Intervention: Comparison of 3 Scores
Authors: Judit Karacsonyi, Larissa Stanberry, Khaldoon Alaswad, Oleg Krestyaninov, James Choi, Bavana Rangan, Ilias Nikolakopoulos, Evangelia Vemmou, Imre Ungi, Emmanouil Brilakis
Journal: Journal of the American College of Cardiology (2020)
The Utility of SPECT/CT in Diagnosing Haglund Syndrome With Bone Scintigraphy
Authors: Patrick Martineau, Matthieu Pelletier-Galarneau
Journal: Clinical Nuclear Medicine (2020)

Abstract Haglund syndrome—the combination of Haglund’s deformity, retrocalcaneal bursitis, and achilles tendinopathy—is a common cause of hind foot pain in adults; however, diagnosis on planar scintigraphy can be challenging. We present a case of Haglund syndrome and show the key role that SPECT/CT can play in its diagnosis.
“Floating” method and “lifting up” method: novel techniques of gastric endoscopic submucosal dissection for treating difficult-to-approach lesions
Authors: Shunsuke Yoshii, Yoshito Hayashi, Ryotaro Uema, Yoshiki Tsujii, Hideki Iijima, Tetsuo Takehara
Journal: Endoscopy (2020)

Endoscopic submucosal dissection (ESD) of lesions located on the lesser curvature of the gastric body is challenging because of the difficulty in approaching the lesion [1]. Although using a multibending endoscope or a special attachment device is a good solution in such a situation [2] [3], these devices are often unavailable except in specialty institutions because of their limited applications and relatively high cost. Here, we present novel techniques using an attachment balloon usually used in endoscopic injection sclerotherapy (EIS) ([Video 1]; [Fig. 1]).
Covid-19: Government shelves plans to invest £100bn in mass testing
Authors: Gareth Iacobucci
Journal: BMJ (2020)

<h3>Background</h3> The published literature provides few insights regarding how to develop or consider the effects of knowledge co-production partnerships in the context of delivery system science. <h3>Objective</h3> To describe how a healthcare organisation–university-based research partnership was developed and used to design, develop and implement a practice-integrated decision support tool for patients with a physician recommendation for colorectal cancer screening. <h3>Design</h3> Instrumental case study. <h3>Participants</h3> Data were ascertained from project documentation records and semistructured questionnaires sent to 16 healthcare organisation leaders and staff, research investigators and research staff members. <h3>Results</h3> Using a logic model framework, we organised the key inputs, processes and outcomes of a healthcare organisation–university-based research partnership. In addition to pragmatic researchers, partnership inputs included a healthcare organisation with a supportive practice environment and an executive-level project sponsor, a mid-level manager to serve as the organisational champion and continual access to organisational employees with relevant technical, policy and system/process knowledge. During programme design and implementation, partnership processes included using project team meetings, standing organisational meetings and one-on-one consultancies to provide platforms for shared learning and problem solving. Decision-making responsibility was shared between the healthcare organisation and research team. We discuss the short-term outcomes of the partnership, including how the partnership affected the current research team’s knowledge and health system initiatives. <h3>Conclusion</h3> Using a logic model framework, we have described how a healthcare organisation–university-based research team partnership was developed. Others interested in developing, implementing and evaluating knowledge co-production partnerships in the context of delivery system science projects can use the experiences to consider ways to develop, implement and evaluate similar co-production partnerships.
Abstract 3074: Benefit of Statin Therapy for Percutaneous Coronary Intervention: A Meta-Analysis
Authors: Girish Mood, Anthony Bavry, Henri Roukoz, Subramanya Prasad, Deepak L Bhatt
Journal: Circulation (2006)

Introduction: The benefit of statin therapy initiated for routine percutaneous coronary intervention (PCI) on adverse cardiovascular outcomes is unknown. Hypothesis: Accordingly, we sought to evalu...
TCT CONNECT-12 A Case Control Study of Percutaneous Coronary Intervention in Spontaneous Coronary Artery Dissection
Authors: Deevia Kotecha, Diluka Premawardhana, Marcos García-Guimaraes, Dario Pellegrini, Jan Ziaullah, Alice Wood, Teresa Bastante Valiente, Angela Maas, Robert-Jan Van Geuns, Fernando Alfonso, David Adlam
Journal: Journal of the American College of Cardiology (2020)
Comment on McIntyre and Moses The Diagnosis and Management of Gestational Diabetes Mellitus in the Context of the COVID-19 Pandemic. Diabetes Care 2020;43:1433–1434
Authors: Basil G. Issa, Lorenz Becker, Kelly Cheer, Anne-Marie Kelly
Journal: Diabetes Care (2020)

We read with interest the article by McIntyre and Moses in the July issue of Diabetes Care (1), which prompted us to look at our data for screening for gestational diabetes mellitus (GDM) in relation to the recently published U.K. Royal College of Obstetricians and Gynaecologists (RCOG) guidelines for maternal medicine during the coronavirus pandemic that include guidance on antenatal care for women with GDM (2). The guidance recommends the use of HbA1c and fasting plasma glucose (FPG) or random plasma glucose (RPG) in a two-step approach at booking and at 28 weeks’ gestation with a recommendation that, at booking, an HbA1c ≥48 mmol/mol or an RPG ≥11.1 mmol/L would be managed as type 2 diabetes in pregnancy and an HbA1c 41–47 mmol/mol or an RPG 9–11 …
TCT CONNECT-95 Association Between Sarcopenia and Mortality After Transcatheter Aortic Valve Replacement
Authors: Colin Neill, William Fearon, Sammy Elmariah, Brian Kim, Samir Kapadia, Dharam Kumbhani, Linda Gillam, Brian Whisenant, Nishath Quader, Alan Zajarias, Frederick Welt, Megan Coylewright, John Carr, Sangeeta Nair, James Terry, Anna Vatterott, Natalie Jackson, Shi Huang, Brian Lindman
Journal: Journal of the American College of Cardiology (2020)
Outcome of Hepatocellular Carcinoma Detected During Surveillance: Comparing USA and Japan
Authors: Hidenori Toyoda, Atsushi Hiraoka, Jocelyn Olivares, Taim Al-Jarrah, Paulina Devlin, Yuji Kaneoka, Atsuyuki Maeda, Adam C. Yopp, Neehar D. Parikh, Amit G. Singal
Journal: Clinical Gastroenterology and Hepatology (2020)
TCT CONNECT-318 Direct Oral Anticoagulants Versus Antiplatelet Therapy in Patients With Peripheral Arterial Disease: Meta-Analysis of Randomized Controlled Trials
Authors: Qais Radaideh, Mohammed Osman, Babikir Kheiri, Ahmad Al-Abdouh, Mahmoud Barbarawi, Ahmad Jabri, Mehul Adhaduk, Ghassan Bachuwa, Jacqueline Tamis-Holland, Nicolas Shammas
Journal: Journal of the American College of Cardiology (2020)
The importance of nutrition in football: perspective of a national team’s doctor
Authors: Tim Meyer
Journal: British Journal of Sports Medicine (2020)

Although football players’ average energy requirements fall below those of pure endurance athletes or sports with more extensive training schedules, football is nevertheless a physically demanding sport. Top-level footballers can spend up to 11 months of the year playing one or more matches a week and train almost daily during that period. Players must be physically well prepared and they must also receive the right amounts of energy and micronutrients to support training. A specific and individualised nutrition plan should be tailored to a player’s needs.

A healthy diet focussing on ‘food first’ may help players to limit the risk of becoming ill or suffering an injury. Consuming appropriate and adequate nutrients (eg, carbohydrates, proteins, etc) before and after matches and high-intensity training sessions can help to support a player’s performance and speed up recovery. Consequently, nutrition plans should be tailored to the amount and type of energy that is required for each training session and competition, as well as any requirements that are imposed by other circumstances (such as travelling and private pressures). In addition to a player’s individual load, a plan can also take account of their …
Association of Infection With Human Papillomavirus and Development of End-Stage Kidney Disease in Taiwan
Authors: Renin Chang, Ming Li Chen, Cheng-Li Lin, Yao-Min Hung, James Cheng-Chung Wei
Journal: JAMA Network Open (2020)

<h3>Importance</h3> The association between human papillomavirus (HPV) infection status and the natural process of kidney diseases has been neglected as an area of research. Further studies are needed to clarify factors that may alter the progression of end-stage kidney disease (ESKD). <h3>Objective</h3> To describe the rates of ESKD among patients with and without HPV infection. <h3>Design, Setting, and Participants</h3> In this nationwide, population-based retrospective cohort study, data were collected from the National Health Insurance Research Database of Taiwan. A total of 76 088 individuals with HPV infection were enrolled from January 1, 2000, to December 31, 2012, and compared with a control group of 76 088 individuals who had never been diagnosed with HPV infection (at a 1:1 ratio propensity-score matched by age, sex, index year, and comorbidities) in the context of the risk of developing ESKD. Statistical analysis was performed between November 2019 and July 2020. <h3>Exposures</h3> HPV infection was defined according to the<i>International Classification of Diseases, Ninth Revision, Clinical Modification</i>codes<i>.</i> <h3>Main Outcomes and Measures</h3> The main outcome was ESKD, as recorded in the Catastrophic Illness Patients database. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% CIs, with the control group as a reference. <h3>Results</h3> Of 152 176 individuals (79 652 [52.3%] women; mean [SD] age, 34.4 [19.1] years), 76 088 individuals (50.0%) had HPV and 463 individuals (0.3%) developed ESKD. Incidence of ESKD was lower in individuals with HPV history than in those without HPV history (3.64 per 10 000 person-years vs 4.80 per 10 000 person-years). In the fully adjusted multivariate Cox proportional hazards regression model, individuals with a history of HPV infection had a significant decrease in risk of ESKD (adjusted HR, 0.72; 95% CI, 0.60-0.87) after adjusting for demographic characteristics, comorbidities, and comedications. In the subgroup analysis, individuals ages 50 to 64 years with HPV infection had a statistically significantly lower risk of ESKD compared with individuals ages 50 to 64 years with no HPV infection (adjusted HR, 0.48; 95% CI, 0.34-0.68;<i>P</i> &lt; .001), while there was no significant reduction in risk for the other age groups (ie, 0-19, 20-49, and 65-100 years). <h3>Conclusions and Relevance</h3> In this study, a history of HPV infection was associated with a lower risk of subsequent ESKD. The mechanism behind this protective association remains uncertain. Future studies are required to clarify the possible biological mechanisms.
TCT CONNECT-29 Vasopressors Have Independent Adverse Impact on Survival in Patients With Acute Myocardial Infarction Cardiogenic Shock
Authors: Mir Basir, Angela Taylor, Alejandro Lemor, Sarah Gorgis, Behnam Tehrani, Alexander Truesdell, Aditya Bharadwaj, Brian Kolski, Joseph Gelormini, Josh Todd, David Lasorda, Craig Smith, Robert Riley, Steven Marso, Robert Federici, William O'Neill
Journal: Journal of the American College of Cardiology (2020)
TCT CONNECT-425 Impact of the Use of a Dominant Forearm Artery on the Complications and Efficacy of Transradial and Transulnar Access: A Randomized Trial With Pre-Procedural Ultrasonography
Authors: Pawel Lewandowski, Anna Zuk, Tomasz Slomski, Pawel Maciejewski, Ramotowski Bogumil, Andrzej Budaj
Journal: Journal of the American College of Cardiology (2020)
Multi-transcription factor reporter mice delineate early precursors to the ILC and LTi lineages
Authors: Darshan N. Kasal, Albert Bendelac
Journal: The Journal of Experimental Medicine (2020)

Transcription factor (TF) reporter mice have proved integral to the characterization of murine innate lymphoid cell (ILC) development and function. Here, we implemented a CRISPR/Cas9-generated combinatorial reporter approach for the simultaneous resolution of several key TFs throughout ILC development in both the fetal liver and adult bone marrow. We demonstrate that the Tcf7-expressing early innate lymphoid precursor (EILP) and the common helper ILC precursor (CHILP) both contain a heterogeneous mixture of specified ILC and lymphoid tissue inducer (LTi) precursors with restricted lineage potential rather than a shared precursor. Moreover, the earliest specified precursor to the LTi lineage was identified upstream of these populations, before Tcf7 expression. These findings match dynamic changes in chromatin accessibility associated with the expression of key TFs (i.e., GATA3 and RORγ(t)), highlighting the distinct origins of ILC and LTi lineages at the epigenetic and functional levels, and provide a revised map for ILC development.
TCT CONNECT-296 Use of Endovascular Percutaneous Vascular Closure Device as Compared to Surgical Cutdown for Decannulation in Veno-Arterial Extracorporeal Membrane Oxygenation (VA ECMO)
Authors: Mehul Desai, Liam Ryan, Eric Sarin, Kathleen Petro, Erik Osborn, Daniel Tang, James Lantry, Alan Speir, Ramesh Singh
Journal: Journal of the American College of Cardiology (2020)
Association of Damaging Variants in Genes With Increased Cancer Risk Among Patients With Congenital Heart Disease
Authors: Sarah U. Morton, Akiko Shimamura, Peter E. Newburger, Alexander R. Opotowsky, Daniel Quiat, Alexandre C. Pereira, Sheng Chih Jin, Michelle Gurvitz, Martina Brueckner, Wendy K. Chung, Yufeng Shen, Daniel Bernstein, Bruce D. Gelb, Alessandro Giardini, Elizabeth Goldmuntz, Richard W. Kim, Richard P. Lifton, George A. Porter, Deepak Srivastava, Martin Tristani-Firouzi, Jane W. Newburger, J. G. Seidman, Christine E. Seidman
Journal: JAMA Cardiology (2020)

Patients with congenital heart disease (CHD), the most common birth defect, have increased risks for cancer. Identification of the variables that contribute to cancer risk is essential for recognizing patients with CHD who warrant longitudinal surveillance and early interventions.