tbuckley/cabot-search huggingface dataset:
Abstract 17343: Median Levels and 99th Percentiles of High-Sensitive Troponin T in Different Groups of Chest Pain Patients in the Emergency Department
Authors: Tobias Reichlin, Raphael Twerenbold, Philip Haaf, Miriam Reiter, Julia Meissner, Stefan Osswald, Christian Mueller
Journal: Circulation (2010)

Background: The 99th percentile of troponin in healthy individuals has been defined as decision limit for the diagnosis of acute myocardial infarction (AMI) in current guidelines. The median levels...
Abstract 1997: Reduced Door-to-Balloon Time in ST Elevation Myocardial Infarction as a Consequence of Formalized Data Analysis and Feedback
Authors: Friederike K Keating, Dorothe Ahlersmann, Reinhard Hilgers, Holger Duwald, Rolf Nitsche, Georg Von Knobelsdorff, Karsten Moeller, Karl H Scholz
Journal: Circulation (2007)

Background : Formalized data feedback is one strategy proposed to reduce treatment time in ST elevation myocardial infarction (STEMI). We prospectively evaluated the effect of systematic data analysis and feedback on door-to-balloon time and on components of treatment time in a German semirural hospital network. Methods : Consecutive patients presenting with STEMI over a one-year period (2006) were enrolled (n=114). The 3-hospital network included one hospital with primary percutaneous coronary intervention (PCI) capacity. Protocols were in place to ensure prompt transfer of patients with STEMI to the PCI center and to minimize time to treatment. They included obtaining and transmitting pre-hospital 12-lead ECGs, bypassing non-PCI hospitals, and bypassing the emergency room with direct transfer to the cardiac catheterization laboratory (CCL) when feasible. No changes were made to these treatment protocols during the study period. On a quarterly basis, data on time to treatment and its components, from initial patient contact to balloon inflation, were collected, presented to, and discussed with staff involved in the initial evaluation, transfer, and treatment of the patients. Comparisons between quarters were made with the Gehan and Pearson χ 2 tests. Results : The longest transport distance was 29 miles, and the longest transport time was 47 minutes. Mean (median) door-to-balloon times decreased from 63 (54) minutes during the first quarter to 47 (35), 37 (31), and 36 (26) minutes during the next 3 quarters (p&lt;0.0001). Significant reductions were observed in the time between arrival at the PCI center and arrival in the CCL (p&lt;0.02), and in the time from arrival in the CCL to balloon inflation (p&lt;0.01). There was a nonsignificant increase in the proportion of patients with a transmitted 12-lead ECG (p=0.12). By contrast, the proportion of patients who bypassed the emergency room increased markedly (from 23% during the first quarter to 76% during the 4 th quarter, p= 0.0023). Conclusion : Formalized data feedback can lead to a marked reduction in door-to-balloon times for STEMI. This is in part due to changes in pre-hospital decision making (bypassing the emergency room).
Disparities in Cancer-Related Mortality and Long-Term Survival in Adolescent and Young Adults with Hodgkin Lymphoma: A Population-Level Analysis across the United States
Authors: Justine M. Kahn, Theresa H.M. Keegan, Elysia Alvarez, Lori S Muffly, Helen Parsons, Lena E. Winestone, Archie Bleyer
Journal: Blood (2018)
Volume Replacement Fluid Demarks Benign Insulinoma With 68Ga-DOTA-Exendin-4 PET/CT
Authors: Kwadwo Antwi, Guillaume Nicolas, Melpomeni Fani, Emanuel Christ, Damian Wild
Journal: Clinical Nuclear Medicine (2019)

Insulinomas are often difficult to localize. We present a 47-year-old woman who had recurrent neuroglycopenic symptoms and positive Whipple triad for 28 months. The 14 hours of fasting test confirmed the diagnosis of endogenous hyperinsulinemic hypoglycemia which is highly suspicious for the presence of an insulinoma. Previously performed MRI, endoscopic ultrasound, In-pentetreotide SPECT/CT, and Ga-DOTA-exendin-4 PET/CT did not show any evidence of an insulinoma. Subsequently, Ga-DOTA-exendin-4 PET/CT was repeated with the previous infusion of a colloidal volume replacement fluid (Gelofusine), known to reduce Ga-DOTA-exendin-4 accumulation in the kidneys. Consequently, the insulinoma was unmasked from the left kidney, allowing curative surgery.
Targeted Magnetic Resonance Imaging and Modulation of Hypoxia with Multifunctional Hyaluronic Acid‐MnO<sub>2</sub> Nanoparticles in Glioma
Authors: Chaoping Fu, Xiaohui Duan, Minghui Cao, Shuqi Jiang, Xiaohua Ban, Na Guo, Fang Zhang, Jiaji Mao, Ting Huyan, Jun Shen, Li Ming Zhang
Journal: Advanced Healthcare Materials (2019)

Manganese dioxide (MnO2 )-based nanoparticles are a promising tumor microenvironment-responsive nanotheranostic carrier for targeted magnetic resonance imaging (MRI) and for alleviating tumor hypoxia. However, the complexity and potential toxicity of the present common synthesis methods limit their clinical application. Herein, multifunctional hyaluronic acid-MnO2 nanoparticles (HA-MnO2 NPs) are synthesized in a simple way by directly mixing sodium permanganate with HA aqueous solutions, which serve as both a reducing agent and a surface-coating material. The obtained HA-MnO2 NPs show an improved water-dispersibility, fine colloidal stability, low toxicity, and responsiveness to the tumor microenvironment (high H2 O2 and high glutathione, low pH). After intravenous injection, HA-MnO2 NPs exhibit a high imaging sensitivity for detecting rat intracranial glioma with MRI for a prolonged period of up to 3 d. These nanoparticles also effectively alleviate the tumor hypoxia in a rat model of intracranial glioma. The downregulation of VEGF and HIF-1α expression in intracranial glioma validates the sustained attenuation effect of HA-MnO2 NPs on tumor hypoxia. These results show that HA-MnO2 NPs can be used for sensitive, targeted MRI detection of gliomas and simultaneous attenuation of tumor hypoxia.
Effectiveness of Acyclovir Prophylaxis Against Varicella Zoster Virus Infection after Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis
Authors: Yuko Shimosato-Wada, Reo Tanoshima, Kanako Hiratoko, Masanobu Takeuchi, Shinichi Tujimoto, Norio Shiba, Shinya Ito, Takeharu Yamanaka, Shuichi Ito
Journal: Blood (2017)
Preclinical Evaluation of the First in Class BMI1 Inhibitor PTC-028 Confirms Potent Efficacy to Target BMI1-Addiction in Multiple Myeloma
Authors: Arnold Bolomsky, Roy Heusschen, Kathrin Stangelberger, Muller Joséphine, Marla Weetall, Art Branstrom, Niklas Zojer, Jo Caers, Heinz Ludwig
Journal: Blood (2017)
Visualization of early events in mRNA vaccine delivery in non-human primates via PET–CT and near-infrared imaging
Authors: Kevin E. Lindsay, Sushma M. Bhosle, Chiara Zurla, Jared Beyersdorf, Kenneth A. Rogers, Daryll Vanover, Peng Xiao, Mariluz Araínga, Lisa M. Shirreff, Bruno Pitard, Patrick Baumhof, Francois Villinger, Philip J. Santangelo
Journal: Nature Biomedical Engineering (2019)
Abstract 9039: Predictors of High Defibrillation Energy Requirements: Results From the NCDR ICD Registry
Authors: Andrea M Russo, Sana M Al-Khatib, Yongfei Wang, Jeptha Curtis, Greg M Marcus, Jonathan C Hsu, Nitesh Sood, Matthew W Parker, Jeffrey Kluger, Rachel Lampert
Journal: Circulation (2012)

Background: Defibrillation testing is typically performed at the time of ICD implantation to establish effective arrhythmia termination. Despite technological advancements, including biphasic waveforms and higher output devices, an inadequate safety margin for defibrillation may still occur. The NCDR ICD Registry was examined to evaluate predictors of a high defibrillation requirement (DER) using modern day devices. Methods: Patients who underwent defibrillation testing in the NCDR ICD Registry were examined to determine characteristics associated with a high DER. This included 45,686 initial ICD implantation procedures from April 2010 to December 2010 performed at 1261 facilities. Patient characteristics were compared using chi-square tests for categorical variables and unbalanced t-tests for continuous variables. Multivariable logistic regression was used to assess independent predictors of a "high" DER, which was defined as &gt;25 joules. Results: A high DER was noted in 4.1% of patients undergoing testing. Patients with a high DER were more often younger, male, on dialysis, and were more likely to have a higher NYHA functional class, lower LVEF, higher creatinine, and wider QRS. Patients on antiarrhythmic drugs and those with nonischemic heart disease were more likely to have a high DER. Independent predictors of a high DER included younger age, higher NYHA class, and increased QRS duration. A high DER was associated with longer post-procedure length of stay (1.6 ± 2.9 vs. 2.1 ± 3.8 days, p&lt;0.001) as well as any complication or death prior to hospital discharge (2.6% vs. 4.0%, p&lt;0.001). Conclusions: A high DER was observed in 4.1% of patients and was associated with more complications and mortality. Several clinical predictors of a high DER were identified, potentially enabling the identification of patients most likely to benefit from testing. Additional study is needed to determine if testing predicts long-term outcome of patients with modern day devices.
Bypass Surgery or Stenting for Left Main Coronary Artery Disease in Patients With Diabetes
Authors: Milan Milojevic, Patrick W. Serruys, Joseph F. Sabik, David E. Kandzari, Erick Schampaert, Ad J. van Boven, Ferenc Horkay, Imre Ungi, Samer Mansour, Adrian P. Banning, David P. Taggart, Manel Sabaté, Anthony H. Gershlick, Andrzej Bochenek, Jose Pomar, Nicholas J. Lembo, Nicolas Noiseux, John D. Puskas, Aaron Crowley, Ioanna Kosmidou, Roxana Mehran, Ori Ben-Yehuda, Philippe Généreux, Stuart J. Pocock, Charles A. Simonton, Gregg W. Stone, Arie Pieter Kappetein
Journal: Journal of the American College of Cardiology (2019)
2019 update of the EULAR recommendations for the management of systemic lupus erythematosus
Authors: Antonis Fanouriakis, Myrto Kostopoulou, Alessia Alunno, Martin Aringer, Ingeborg Bajema, John N Boletis, Ricard Cervera, Andrea Doria, Caroline Gordon, Marcello Govoni, Frédéric Houssiau, David Jayne, Marios Kouloumas, Annegret Kuhn, Janni L Larsen, Kirsten Lerstrøm, Gabriella Moroni, Marta Mosca, Matthias Schneider, Josef S Smolen, Elisabet Svenungsson, Vladimir Tesar, Angela Tincani, Anne Troldborg, Ronald van Vollenhoven, Jörg Wenzel, George Bertsias, Dimitrios T Boumpas
Journal: Annals of the Rheumatic Diseases (2019)

Our objective was to update the EULAR recommendations for the management of systemic lupus erythematosus (SLE), based on emerging new evidence. We performed a systematic literature review (01/2007-12/2017), followed by modified Delphi method, to form questions, elicit expert opinions and reach consensus. Treatment in SLE aims at remission or low disease activity and prevention of flares. Hydroxychloroquine is recommended in all patients with lupus, at a dose not exceeding 5 mg/kg real body weight. During chronic maintenance treatment, glucocorticoids (GC) should be minimised to less than 7.5 mg/day (prednisone equivalent) and, when possible, withdrawn. Appropriate initiation of immunomodulatory agents (methotrexate, azathioprine, mycophenolate) can expedite the tapering/discontinuation of GC. In persistently active or flaring extrarenal disease, add-on belimumab should be considered; rituximab (RTX) may be considered in organ-threatening, refractory disease. Updated specific recommendations are also provided for cutaneous, neuropsychiatric, haematological and renal disease. Patients with SLE should be assessed for their antiphospholipid antibody status, infectious and cardiovascular diseases risk profile and preventative strategies be tailored accordingly. The updated recommendations provide physicians and patients with updated consensus guidance on the management of SLE, combining evidence-base and expert-opinion.
Abstract 20716: The Long-Term Impact of Follow-up Care on Hospitalization and Death in Patients With Atrial Fibrillation Who Receive Emergency Care
Authors: Clare L Atzema, Bing Yu, Michael J Schull, Cynthia A Jackevicius, Noah M Ivers, Douglas S Lee, Paula Rochon, Peter C Austin
Journal: Circulation (2017)

Introduction: With the aging of the population, the large number of patients seen in the emergency department for atrial fibrillation (AF) will continue to rise. Currently 11% die within one year of the visit. Objective: To examine the impact of rapid (within 3 days) and early (within 7 days) outpatient follow-up care, versus delayed or no follow-up care, on outcomes in AF patients discharged from an emergency department. Methods: In this retrospective cohort study using comprehensive administrative health data from all 163 emergency departments in the province of Ontario, Canada, we identified patients aged ≥ 18 years who were discharged from an emergency department with a primary diagnosis of AF between April 2007 and March 2014. We used a propensity-score matched landmark analysis to assess the association of rapid and early follow-up care with one-year and 90-day all-cause mortality, cardiovascular hospitalizations, and 30-day return emergency department visits. Logistic regression modelling was used ...
Real-World Data in Relapsed Refractory Myeloma Patients Treated with Pomalidomide, a Multicenter Turkish Experience
Authors: Omur Gokmen Sevindik, Mustafa Pehlivan, Tulin F Tuglular, Serife M Solmaz, Mehmet Hilmi Dogu, Fevzi Yalniz, Ali Ugur Ural, Zafer Serenli Yeğen, Mutlu Arat, Vildan Ozkocaman, Elif G Umit, Handan Haydaroğlu Şahin, Mehmet Sönmez, Mehmet Turgut, Muhit Ozcan, Onder Arslan, Yildiz Aydin, Tayfun Elibol, Aybuke Harmandali Olgun, Banu Bayar, Anil Tombak, Ismet Aydogdu, Güner Hayri Özsan
Journal: Blood (2017)
Psychiatry
Authors: David W. Hodo
Journal: JAMA (2003)

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A sequential interferon gamma directed chemotactic cellular immune response determines survival and cardiac function post-myocardial infarction
Authors: Stefanie Finger, Maike Knorr, Michael Molitor, Rebecca Schüler, Venkata Garlapati, Ari Waisman, Moritz Brandt, Thomas Münzel, Tobias Bopp, Sabine Kossmann, Susanne Karbach, Philip Wenzel
Journal: Cardiovascular Research (2019)

Myelomonocytic cells are critical in injury and healing post-myocardial infarction (MI). Mechanisms of regulation, however, are incompletely understood. The aim of the study was to elucidate the role of interferon gamma (IFN-γ) in the orchestrated inflammatory response in a murine model of MI.MI was induced in 8- to 12-week-old male mice (C57BL/6 background) by permanent ligation of the left anterior descending (LAD) coronary artery. Lysozyme M (LysM)+ cell-depleted LysMiDTR transgenic mice displayed a reduced influx of CD45.2+/CD3-/CD11b+/Gr-1high neutrophils into infarcted myocardium 1 day post-MI compared with infarcted controls, paralleled by decreased cardiac mRNA levels of IFN-γ and tumour necrosis factor alpha (TNF-α). Mortality after MI was significantly increased in LysM+ cell-depleted mice within 28 days post-MI. To more specifically address the role of neutrophils, we depleted C57BL/6 mice with a monoclonal anti-Gr-1 antibody and found increased mortality, deteriorated cardiac function as well as decreased cardiac IFN-γ mRNA expression early after MI. Ccl2, Cxcl1, Cx3cl1, and Il12b mRNA were reduced 3 days after MI, as was the amount of CD11b+/Ly-6G-/Ly-6Chigh inflammatory monocytes. LAD-ligated Cramp-/- mice lacking cathelicidin important in neutrophil-dependent monocyte chemotaxis as well as IFNγ-/- and TNFα-/- mice phenocopied Gr-1+ cell-depleted mice, supporting a regulatory role of IFN-γ impacting on both the sequence of inflammatory cell invasion and cardiac outcome early after MI. The use of conditional IFN-γ receptor deficient mice indicated a direct effect of IFN-γ on LysM+ cells in cardiac injury post-MI. Using IFN-γ reporter mice and flow cytometry, we identified cardiac lymphoid cells (CD4+ and CD8+ T cells and natural killer cells) as primary source of this cytokine in the cardiac inflammatory response post-MI.IFN-γ directs a sequential chemotactic cellular immune response and determines survival and cardiac function post-MI.
Frequency of Contact Allergy to Implanted Cardiac Devices
Authors: Matthew Gold, Neel Nath, Cynthia Green, Amber Reck Atwater
Journal: JAMA Dermatology (2019)

and psychiatrists should be involved in the early stages of treatment.The limitation of our study is that we could not measure the actual disease duration between psoriasis and the mental health disorders.However, our study was strengthened by the use of standardized, large-population data to identify an association between psoriasis and mental health disorders.The present results demonstrate that psoriasis is associated with a higher risk for developing mental health disorders; therefore, dermatologists should play a role in detecting mental health disorders in patients with psoriasis, and in assembling a multidisciplinary team of medical professionals to treat these patients.
The A‐B‐C of small‐molecule ABC transport protein modulators: From inhibition to activation—a case study of multidrug resistance‐associated protein 1 (ABCC1)
Authors: Michael Wiese, Sven Marcel Stefan
Journal: Medicinal Research Reviews (2019)

Several mechanisms of pharmacokinetic, metabolic, and regulatory nature have been elucidated to take part or act in concert in the phenomenon of multidrug resistance (MDR). MDR is characterized by cross-resistance of cells against chemotherapeutic agents, which are used for treatment of e.g., cancer, bacterial infections, or human immunodeficiency virus (HIV) infections. One group of proteins that combines all three stated aspects-the metabolism and distribution of drugs as well as their own regulation-is adenosine triphosphate-binding cassette (ABC) transporters. These efflux pumps use the energy of adenosine triphosphate hydrolysis for drug translocation from the membrane and the cytosol to the extracellular space, often with cotransport of a cosubstrate. Multidrug resistance-associated protein 1 (MRP1, ABCC1) had been discovered as one major key player in cancer-related MDR. The xenobiotic substrates include anthracyclines, vinca alkaloids, podophyllotoxins, as well as glutathione (GSH)-adducts of certain cytostatics. Contrary to other transport proteins involved in cancer-related MDR the activity of MRP1 is related to the GSH content of cells. A modern strategy to overcome MRP1-associated MDR is besides its inhibition the activation of GSH efflux, enforcing cell death due to cellular stress. In addition, it has recently been found that MRP1 contributes to the β-amyloid protein clearance in Alzheimer's disease (AD). Collectively, transport activation of MRP1 is of therapeutic value, and furthermore helps to elucidate the transport protein function and the mechanisms behind it. This review is meant to summarize the known concepts of MRP1 activation, which might contribute to a further understanding of MRP1 in particular and ABC transporters in general.
Deep learning enables robust assessment and selection of human blastocysts after in vitro fertilization
Authors: Pegah Khosravi, Ehsan Kazemi, Qiansheng Zhan, Jonas E. Malmsten, Marco Toschi, Pantelis Zisimopoulos, Alexandros Sigaras, Stuart Lavery, Lee A. D. Cooper, Cristina Hickman, Marcos Meseguer, Zev Rosenwaks, Olivier Elemento, Nikica Zaninovic, Iman Hajirasouliha
Journal: npj Digital Medicine (2019)

Visual morphology assessment is routinely used for evaluating of embryo quality and selecting human blastocysts for transfer after in vitro fertilization (IVF). However, the assessment produces different results between embryologists and as a result, the success rate of IVF remains low. To overcome uncertainties in embryo quality, multiple embryos are often implanted resulting in undesired multiple pregnancies and complications. Unlike in other imaging fields, human embryology and IVF have not yet leveraged artificial intelligence (AI) for unbiased, automated embryo assessment. We postulated that an AI approach trained on thousands of embryos can reliably predict embryo quality without human intervention. We implemented an AI approach based on deep neural networks (DNNs) to select highest quality embryos using a large collection of human embryo time-lapse images (about 50,000 images) from a high-volume fertility center in the United States. We developed a framework (STORK) based on Google's Inception model. STORK predicts blastocyst quality with an AUC of >0.98 and generalizes well to images from other clinics outside the US and outperforms individual embryologists. Using clinical data for 2182 embryos, we created a decision tree to integrate embryo quality and patient age to identify scenarios associated with pregnancy likelihood. Our analysis shows that the chance of pregnancy based on individual embryos varies from 13.8% (age ≥41 and poor-quality) to 66.3% (age <37 and good-quality) depending on automated blastocyst quality assessment and patient age. In conclusion, our AI-driven approach provides a reproducible way to assess embryo quality and uncovers new, potentially personalized strategies to select embryos.
An international Delphi survey helped develop consensus-based core outcome domains for trials in peritoneal dialysis
Authors: Karine E. Manera, Allison Tong, Jonathan C. Craig, Jenny Shen, Shilpa Jesudason, Yeoungjee Cho, Benedicte Sautenet, Armando Teixeira-Pinto, Martin Howell, Angela Yee-Moon Wang, Edwina A. Brown, Gillian Brunier, Jeffrey Perl, Jie Dong, Martin Wilkie, Rajnish Mehrotra, Roberto Pecoits-Filho, Saraladevi Naicker, Tony Dunning, Nicole Scholes-Robertson, David W. Johnson
Journal: Kidney International (2019)
Level of pancreatic division and postoperative pancreatic fistula after distal pancreatectomy: A retrospective case-control study of 157 patients with non-pancreatic ductal adenocarcinoma lesions
Authors: Marta Silvestri, Antoine Coignac, Julien Delicque, Astrid Herrero, Fréderic Borie, Boris Guiu, Jean-Michel Fabre, Regis Souche
Journal: International Journal of Surgery (2019)
Characterisation of nasal devices for delivery of insulin to the brain and evaluation in humans using functional magnetic resonance imaging
Authors: Jed Wingrove, Magda Swedrowska, Regina Scherließ, Mark Parry, Mervin Ramjeeawon, David Taylor, Gregoire Gauthier, Louise Brown, Stephanie Amiel, Fernando Zelaya, Ben Forbes
Journal: Journal of Controlled Release (2019)