tbuckley/cabot-search huggingface dataset:
Abstract 20696: Platelet-Lymphocyte Ratio Predicts Long Term Mortality in Patients Undergoing Coronary Angiography
Authors: Yun S Lee, Matthew Peverelle, Rohullah Sultani, John Garlick, Andrew M Wilson
Journal: Circulation (2016)

Introduction: Inflammation and thrombocytosis play an important role in the progression of atherosclerosis and coronary artery disease (CAD). We have previously shown that platelet-lymphocyte ratio (PLR) is an independent predictor of presence of CAD in patients aged 55 years or older. Previous studies demonstrated the association between PLR and cardiovascular prognosis. Hypothesis: We hypothesize that PLR predicts long term mortality in patients undergoing coronary angiography, regardless of presence of CAD. Methods: We followed up 525 patients from the BRAVEHEART cohort who were referred for coronary angiography at our institution for a mean period of 5.0±1.3 years. The primary outcome was all-cause mortality. Patients were classified into tertiles based on their pre-angiogram PLR values ( 145.6). Results: There were 53 deaths over the follow-up period and patients in tertile3 (PLR>145.6) had worse prognosis compared with patients in tertile1 and tertile2 (29, 12 and 12 deaths resp...
Treg Downregulation Was Associated with Augmentation of T Cell Responses Against Immunogenic Antigens and Clinical Responses in Patients with Hematological Malignancies after Donor Lymphocyte Infusion (DLI)
Authors: Jochen Greiner, Marlies Götz, Michael Schmitt, Hartmut Döhner, Markus Wiesneth, Donald Bunjes, Susanne Hofmann
Journal: Blood (2018)
Association between overall survival and adverse events with lenvatinib treatment in patients with hepatocellular carcinoma (REFLECT).
Authors: Max W. Sung, Richard S. Finn, Shukui Qin, Kwang-Hyub Han, Kenji Ikeda, Ann-Lii Cheng, Masatoshi Kudo, Ryosuke Tateishi, Masafumi Ikeda, Valery Breder, Kun-Ming Rau, Yuk Ting Ma, Angel Alsina, Baek-Yeol Ryoo, Zhenggang Ren, Kalgi Mody, Corina E. Dutcus, Toshiyuki Tamai, Kenichi Saito, Fabio Piscaglia
Journal: Journal of Clinical Oncology (2019)

317 Background: In the phase 3 REFLECT study, lenvatinib (LEN) demonstrated a treatment effect on overall survival (OS) by statistical confirmation of non-inferiority to sorafenib (SOR) in patients (pts) with unresectable hepatocellular carcinoma (uHCC), who had not received prior treatment for advanced disease (Kudo M et al, Lancet 2018). Lenvatinib is approved in several major markets for the first line systemic treatment of uHCC. The most common adverse events (AEs) in pts treated with LEN were hypertension and diarrhea. In addition, LEN showed a different AE profile from that of SOR. Pts who received LEN experienced more instances of hypertension, proteinuria, dysphonia, and hypothyroidism than patients who received SOR. Recently, hypertension in LEN-treated pts with differentiated thyroid cancer was shown to be correlated with improved efficacy. Here we report the post hoc analysis exploring whether AEs associated with LEN were correlated with longer OS in REFLECT. Methods: 478 Pts were randomized to receive LEN (12 mg/d for actual body weight ≥ 60 kg or 8 mg/d for actual body weight &lt; 60 kg). Subgroup analyses were conducted based on whether pts treated with LEN experienced any-grade AEs of interest (AEIs). OS was estimated by the Kaplan-Meier method. Results: The AEIs in pts treated with LEN were hypertension (42%), diarrhea (38%), proteinuria (24%), dysphonia (24%), and hypothyroidism (16%). OS was longer in pts who had several AEs of interest than in those who did not (table). Conclusions: In pts treated with LEN, the occurrence of hypertension, diarrhea, proteinuria, or hypothyroidism was generally associated with longer OS in pts with uHCC in this post hoc exploratory analysis. The potential confounding factors at baseline should be further investigated. Clinical trial information: NCT01761266. [Table: see text]
Neoadjuvant chemotherapy versus upfront resection in ampullary adenocarcinoma stratified by stage: A retrospective analysis using the National Cancer Database.
Authors: Shravan Leonard-Murali, Rupen A. Shah, Tommy Ivanics, Xiaoxia Han, Christopher P. Steffes, David S. Kwon
Journal: Journal of Clinical Oncology (2019)

318 Background: Outcomes of a neoadjuvant therapy (NAT) strategy to treat ampullary adenocarcinoma (AAC) are unclear. Upfront resection (UR) (typically pancreaticoduodenectomy) with or without adjuvant therapy (AT) is currently the standard of care. We looked to assess outcomes of NAT followed by radical surgery for AAC. Methods: The NCDB was queried for ampullary carcinoma patients from 2004-2015. Patients with Stage I to III AAC who underwent radical surgery were included, and separated into NAT with surgery and UR groups. Demographic/clinical/pathologic data and their associations to survival were analyzed with univariate and multivariate cox proportional hazard models. Overall survival was estimated from time of diagnosis using Kaplan-Meier curves and compared using log-rank tests (LRT) (see table). Statistical analyses were performed using R version 3.5.1 with significance established at p &lt; 0.05. Results: There was no difference in overall survival between the NAT (n = 47) and UR (n = 1521) groups, either as total groups (LRT p = 0.2), or when stratified by stage (stratified LRT p = 0.5). Rates of AT were higher in the UR group (p = 0.038). Receiving AT was significantly associated with improved survival (hazard ratio (HR) = 0.648), while positive nodal status (HR = 2.06), stage 3 disease (HR = 1.542), age &gt; 65 (HR = 1.494), and male gender (HR = 1.241) were significantly associated with decreased overall survival by multivariate analysis. Conclusions: NAT does not offer a survival advantage over UR either overall or for stage-specific disease. This finding extended even to stage III disease, where NAT would theoretically offer greatest benefit. This study suggests that a NAT strategy is not preferable to UR for treatment of resectable AAC, regardless of stage. Higher powered study of NAT for AAC with controls for AT is warranted before discarding a NAT strategy. [Table: see text]
Clinical and Molecular Characteristics of DDX41-Mutated Patients in a Large Cohort of Sporadic MDS/AML
Authors: Marie Sebert, Marie Passet, Anna Raimbault, Samuel Quentin, Nadia Vasquez, Ramy Rahmé, Emmanuel Raffoux, Flore Sicre De Fontbrune, Regis Peffault De Latour, Raphael Itzykson, Pierre Fenaux, Jean Soulier, Lionel Ades, Emmanuelle Clappier
Journal: Blood (2018)
Education can ‘change the world’: Can clinical education change the trajectory of individuals with back pain?
Authors: Mary O’Keeffe, Peter B O’Sullivan, Kieran O’Sullivan
Journal: British Journal of Sports Medicine (2019)

This fourth and final BJSM editorial spotlighting Lancet ’s 2018 low back pain (LBP) series1 2 focuses on four ways clinicians can provide patients with an invaluable treatment—education. This editorial excludes public education via mass media as that has been covered previously.3

Nelson Mandela asserted that ‘Education is the most powerful weapon you can use to change the world’ and education is recognised as the first line treatment for individuals with LBP.1 2 Education is a low-risk, low-cost intervention—the foundation for managing LBP. At the same time education’s modest effect size means it is not a panacea for the condition. In this editorial we aim to provide BJSM readers with a four-step accelerated and concise summary of how to use the education evidence to treat individuals with back pain.

Traditional clinical training prepares us to ask people with LBP a series of questions to help pinpoint the pain ‘source’ to guide management. However, we are usually unable to identify any one source or pain generator, and instead LBP involves a complex interplay of multiple factors.4 Therefore, gathering …
Age of Initiation of Cervical Cancer Screening
Authors: James A. Dickinson
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Retrospective Analysis of Modified Hyper-CVAD Therapy Combined with Proteasome Inhibition for Patients with Multiple Myeloma and Renal Insufficiency or Renal Failure
Authors: Derek Galligan, Rupa Narayan, Sarah Kim, Ann Lazar, Marisela Tan, Richard Fong, Mimi Lo, Nina Shah, Shagun Arora, Sandy W. Wong, Thomas G. Martin, Jeffrey Lee Wolf
Journal: Blood (2018)
Overall Quality of Care Predicts the Variability of Key Risk Factors for Complications in Type 2 Diabetes: An Observational, Longitudinal Retrospective Study
Authors: Antonio Ceriello, Maria Chiara Rossi, Salvatore De Cosmo, Giuseppe Lucisano, Roberto Pontremoli, Paola Fioretto, Carlo Giorda, Antonio Pacilli, Francesca Viazzi, Giuseppina Russo, Antonio Nicolucci
Journal: Diabetes Care (2019)

OBJECTIVE An association between variability in clinical parameters (HbA1c, blood pressure, cholesterol, and uric acid) and risk of complications in type 2 diabetes has been reported. In this analysis, we investigated to what extent such variability is associated with overall quality of care. RESEARCH DESIGN AND METHODS The quality of care summary score (Q-score) represents a validated, overall quality of care indicator ranging between 0 and 40; the higher the score, the better the quality of care provided by the diabetes center. We identified patients with five or more measurements of clinical parameters after the assessment of the Q-score. Multiple linear regression analyses assessed the role of the Q-score in predicting the variability of the different parameters. RESULTS Overall, 273,888 patients were analyzed. The variability of all the parameters systematically increased with decreasing Q-score values. At multivariate linear regression analysis, compared with a Q-score &amp;gt;25, a score &amp;lt;15 was associated with a significantly larger variation in HbA1c, blood pressure, uric acid, total cholesterol, and LDL cholesterol and a lower variation in HDL cholesterol. The analysis of standardized β coefficients show that the Q-score has a larger impact on the variability of HbA1c (0.34; P &amp;lt; 0.0001), systolic blood pressure (0.21; P &amp;lt; 0.0001), total cholesterol (0.21; P &amp;lt; 0.0001), and LDL cholesterol (0.20; P &amp;lt; 0.0001). CONCLUSIONS The variability of risk factors for diabetic complications is associated with quality of care. Quality of care improvement initiatives should be targeted to increase the achievement of the recommended target while reducing such variability.
Autoimmune seizures and epilepsy
Authors: Christian Geis, Jesus Planagumà, Mar Carreño, Francesc Graus, Josep Dalmau
Journal: Journal of Clinical Investigation (2019)

The rapid expansion in the number of encephalitis disorders associated with autoantibodies against neuronal proteins has led to an incremental increase in use of the term "autoimmune epilepsy," yet has occurred with limited attention to the physiopathology of each disease and genuine propensity to develop epilepsy. Indeed, most autoimmune encephalitides present with seizures, but the probability of evolving to epilepsy is relatively small. The risk of epilepsy is higher for disorders in which the antigens are intracellular (often T cell–mediated) compared with disorders in which the antigens are on the cell surface (antibody-mediated). Most autoantibodies against neuronal surface antigens show robust effects on the target proteins, resulting in hyperexcitability and impairment of synaptic function and plasticity. Here, we trace the evolution of the concept of autoimmune epilepsy and examine common inflammatory pathways that might lead to epilepsy. Then, we focus on several antibody-mediated encephalitis disorders that associate with seizures and review the synaptic alterations caused by patients' antibodies, with emphasis on those that have been modeled in animals (e.g., antibodies against NMDA, AMPA receptors, LGI1 protein) or in cultured neurons (e.g., antibodies against the GABAb receptor).
Impact of Clinical Versus Biochemical Progression on Post-Progression Survival in Multiple Myeloma
Authors: Rajshekhar Chakraborty, Hien D. Liu, Lisa Rybicki, Robert M. Dean, Beth M. Faiman, Matt Kalaycio, Jack Khouri, Christy J. Samaras, Navneet S. Majhail, Jason Valent
Journal: Blood (2018)
Tissue Engineering: Functionalization of PLLA with Polymer Brushes to Trigger the Assembly of Fibronectin into Nanonetworks (Adv. Healthcare Mater. 3/2019)
Authors: Mark Robert Sprott, Gloria Gallego‐Ferrer, Matthew J. Dalby, Manuel Salmerón‐Sánchez, Marco Cantini
Journal: Advanced Healthcare Materials (2019)

In article number 1801469 by Manuel Salmerón-Sánchez, Marco Cantini, and co-workers, functional poly(ethyl acrylate) brushes grafted on a biodegradable poly lactic acid scaffold, via surface-initiated atomic transfer radical polymerization, trigger the formation of fibronectin nanonetworks that target cell adhesion and differentiation for application in regenerative medicine. The cover image was prepared by Mark Robert Sprott and Sara Trujillo.
Abstract 19128: Acute Changes in Left Ventricular Contractility Following Mitraclip Implantation Depend on Left Atrial Volume
Authors: Kristina M Dahlem, Julia Winkelmann, Michael Huntgeburth, Henrik ten Freyhaus, Roman Pfister, Stephan Baldus, Volker Rudolph
Journal: Circulation (2014)

Background: The acute hemodynamic changes following elimination of mitral regurgitation is a much discussed issue, particularly in patients with severely compromised left ventricular function where the incompetent mitral valve was regarded as a pop-off valve. Herein, we investigated the acute changes of ventricular contractility in relation to left atrial volume. Methods and results: Echocardiographic left atrial and left ventricular longitudinal strain measurements before and 3 days after the procedure were performed in 19 patients (mean age: 77.9±7.9, 47% female, 73,7% functional mitral valve regurgitation, 26,3% degenerative mitral valve regurgitation) undergoing MitraClip implantation at our institution. Procedural success with reduction in MR to grade 2+ or less was achieved in all patients. Overall there was no significant change in left atrial or ventricular global or regional longitudinal strain after the procedure. However, a strong correlation was observed between worsening in left ventricular strain and left atrial volume (r: -0.72, p&lt;0.01), i.e. there was a greater reduction in left ventricular contractility after clip implantation in patients with larger left atrial volumes. Multivariate, linear regression analyses revealed that left atrial volume predicted the change of left ventricular longitudinal strain following MitraClip implantation (r2: -0.07, p&lt;0.01) independently of left ventricular ejection fraction (r2: -0.05, p=0.40), mitral regurgitant volume (r2: -0.09, p=0.09) and left atrial strain (r2: -0.03, p=0.85). Discussion: Our data suggest that enlarged left atria act as a low-resistance reservoir in mitral regurgitation. As a consequence elimination of mitral regurgitation in these patients leads to worsening of left ventricular contractility whereas in smaller atria left ventricular contractility is not negatively affected by elimination of MR.
Soluble Fibers Improve Metabolic Syndrome but May Cause Liver Disease and Hepatocellular Carcinoma
Authors: Wen Wen, Robert F. Schwabe
Journal: Hepatology (2019)

Wen, Wen Ph.D.1; Schwabe, Robert F. M.D.1,2Editor(s): Corey, Kathleen E.3; Malhi, Harmeet4 Author Information
Delivering the Thinking Healthy Programme for perinatal depression through volunteer peers: a cluster randomised controlled trial in Pakistan
Authors: Siham Sikander, Ikhlaq Ahmad, Najia Atif, Ahmed Zaidi, Fiona Vanobberghen, Helen A Weiss, Anum Nisar, Hanani Tabana, Qurat Ul Ain, Amina Bibi, Samina Bilal, Tayyiba Bibi, Rakshanda Liaqat, Maria Sharif, Shaffaq Zulfiqar, Daniela C Fuhr, LeShawndra N Price, Vikram Patel, Atif Rahman
Journal: The Lancet Psychiatry (2019)
Environmental exposures and mechanisms in allergy and asthma development
Authors: Liza Bronner Murrison, Eric B. Brandt, Jocelyn Biagini Myers, Gurjit K. Khurana Hershey
Journal: Journal of Clinical Investigation (2019)

Environmental exposures interplay with human host factors to promote the development and progression of allergic diseases. The worldwide prevalence of allergic disease is rising as a result of complex gene-environment interactions that shape the immune system and host response. Research shows an association between the rise of allergic diseases and increasingly modern Westernized lifestyles, which are characterized by increased urbanization, time spent indoors, and antibiotic usage. These environmental changes result in increased exposure to air and traffic pollution, fungi, infectious agents, tobacco smoke, and other early-life and lifelong risk factors for the development and exacerbation of asthma and allergic diseases. It is increasingly recognized that the timing, load, and route of allergen exposure affect allergic disease phenotypes and development. Still, our ability to prevent allergic diseases is hindered by gaps in understanding of the underlying mechanisms and interaction of environmental, viral, and allergen exposures with immune pathways that impact disease development. This Review highlights epidemiologic and mechanistic evidence linking environmental exposures to the development and exacerbation of allergic airway responses.
Abstract IA03: Translating genomic risk into an early detection strategy for sarcoma
Authors: Mark Pinese, Mandy Ballinger, David Thomas
Journal: Clinical Cancer Research (2018)

Abstract Sarcomas are a heterogeneous and rare group of cancers that particularly afflict younger populations. We have developed the International Sarcoma Kindred Study (ISKS) to understand the genetic basis of sarcomas as a population. The ISKS has recruited almost 2,300 families from 21 centers in 7 countries, and has clinical information on over 71,000 relatives of affected probands. Using a 72-cancer gene panel, we identified enrichment of monogenic and polygenic variation amongst sarcoma patients, and which correlated with age at first cancer diagnosis. We identified that 6-8% of subjects unselected for family history carried apparently pathogenic alleles in dominant cancer genes, and that 25% of subject carry variants of potential therapeutic significance. The correlation with family patterns or classic cancer phenotypes was inconsistent. However, panel tests are limited by both exonic gene content, and cannot capture many kinds of structural variation. We report here the initial results of whole genome sequencing on over 1,100 sarcoma probands, and case:control and age-of-onset analyses to exhaustively map sarcoma-associated rare and common germline genetic variation. Citation Format: Mark Pinese, Mandy Ballinger, David Thomas, for the International Sarcoma Kindred Study. Translating genomic risk into an early detection strategy for sarcoma [abstract]. In: Proceedings of the AACR Conference on Advances in Sarcomas: From Basic Science to Clinical Translation; May 16-19, 2017; Philadelphia, PA. Philadelphia (PA): AACR; Clin Cancer Res 2018;24(2_Suppl):Abstract nr IA03.
Abstract 17653: Primary Percutaneous Coronary Intervention at Centers With and Without On-site Surgical Support
Authors: Majed Afana, Hitinder S Gurm, Milan Seth, Kathleen M Frazier, Sheryl Fielding, Gerald C Koenig
Journal: Circulation (2017)

Introduction: Primary percutaneous coronary intervention (PPCI) is increasingly performed nationally at sites without on-site cardiac surgery; however, recent guidelines only provide a Class IIa re...
Further Consideration of the Pigmented Lesion Assay—Reply
Authors: Daniel M. Siegel, John Hornberger
Journal: JAMA Dermatology (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Novel Mechanism of Post-Transcriptional Regulation of PD-L1 Expression By 3'-UTR Binding Proteins
Authors: Yasunori Kogure, Keisuke Kataoka, Shungo Adachi, Yosaku Watatani, Ayana Kon, Kenichi Yoshida, Masahiro Nakagawa, Tomohisa Hatta, Tohru Natsume, Seishi Ogawa
Journal: Blood (2017)