tbuckley/cabot-search huggingface dataset:
Symptoms and diagnosis of anxiety and depression in atopic dermatitis in U.S. adults
Authors: J.I. Silverberg, J.M. Gelfand, D.J. Margolis, M. Boguniewicz, L. Fonacier, M.H. Grayson, P.Y. Ong, Z.C. Chiesa Fuxench, E.L. Simpson
Journal: British Journal of Dermatology (2019)

The relationship between atopic dermatitis (AD), anxiety and depression in the U.S. adult population is not well established. To determine the relationship of AD and its severity with symptoms and diagnosis of anxiety and depression in U.S. adults. A cross‐sectional, population‐based study of 2893 adults was performed. AD was determined using modified U.K. Diagnostic Criteria. Adults with AD vs. those without AD had higher mean Hospital Anxiety and Depression Scale anxiety (HADS‐A) (7·7 vs. 5·6) and depression (HADS‐D) (6·0 vs. 4·3) scores and higher prevalences of abnormal (≥ 11) HADS‐A (28·6% vs. 15·5%) and HADS‐D (13·5% vs. 9·0%) scores. In multivariable linear and logistic regression models controlling for sociodemographics, AD was associated with significantly higher mean HADS‐A and HADS‐D scores (7·7 and 6·0) and higher odds of abnormal HADS‐A [odds ratio (OR) 2·19, 95% confidence interval (CI) 1·65–2·91] and HADS‐D scores (OR 1·50, 95% CI 1·04–2·17) (P ≤ 0·03 for all). Mean and abnormal HADS‐A and HADS‐D scores were increased in moderate and severe/very severe self‐reported global AD severity, Patient‐Oriented Eczema Measure (POEM), Patient‐Oriented Scoring AD (PO‐SCORAD), PO‐SCORAD itch and sleep (P < 0·0001 for all). All respondents with severe PO‐SCORAD, POEM and PO‐SCORAD itch had borderline or abnormal HADS‐A and HADS‐D scores. Adults with AD vs. those without AD had higher prevalence of self‐reported healthcare‐diagnosed anxiety or depression in the past year (40·0% vs. 17·5%). Many adults with AD who had borderline and/or abnormal HADS‐A or HADS‐D scores reported no diagnosis of anxiety or depression. AD is associated with significantly increased anxiety and depression, which may go undiagnosed. What's already known about this topic? Previous studies found higher rates of anxiety and depression in clinical cohorts of patients with atopic dermatitis. What does this study add? This study found dramatically higher rates of anxiety and depression among adults with atopic dermatitis in the U.S. population, which was primarily driven by atopic dermatitis severity. Anxiety and depression often go undiagnosed in adults with atopic dermatitis.
Abstract P397: Neighborhood Environment Perceptions Associate With Depression Levels and Cardiometabolic Risk: Data From the Washington, DC Cardiovascular Health and Needs Assessment
Authors: Marcus R Andrews, Joniqua N Ceasar, Kosuke Tamura, Valerie Mitchell, Steven Langerman, Billy Collins, Yvonne Baumer, Cristhian Gutierrez Huerta, Amit Dey, Martin Playford, Nehal Mehta, Tiffany Powell-Wiley
Journal: Circulation (2019)

Background: Little is understood about associations between perceived neighborhood characteristics and depression, a known cardiovascular (CV) disease risk factor, in diverse populations. We examined the relationship between neighborhood environment perception (NEP), depression, and CV disease markers within an urban, predominantly African-American (AA) cohort. Methods: We conducted the DC CV Health and Needs Assessment, a health evaluation among adults (n=100) in resource-limited DC communities. We measured overall NEP and factor analysis identified three NEP sub-scores: 1) neighborhood violence; 2) physical environment; and 3) social cohesion (higher score=more favorable NEP). Depression was defined by the revised Center for Epidemiologic Studies Depression Scale (CESD-R, higher score=higher depression likelihood). We leveraged linear regression modeling to examine NEP and depression associations adjusting for race, income, Framingham risk score, and neighborhood deprivation index (NDI). A population subset (n=42) provided blood samples which were tested for levels of IL-1β, IL-18, and CRP by ELISA (Mesoscale Diagnostics, USA). Results: Participants (n= 100; mean age = 59; 99% AA) had a mean CESD-R score=5.8 (SD=8.9) and mean NEP score=56.1 (SD=12.6). In fully adjusted models, more favorable NEP, specifically physical environment and social cohesion, was associated with significantly lower CESD-R scores (Figure). Higher CESD-R scores were positively associated with increasing IL-1β (β= 20.3 p&lt;.01) and IL-18 (β=0.006 p&lt;.01). Conclusions: More favorable perceptions of one’s neighborhood are related to lower depression symptoms in a predominantly AA cohort from Washington, DC resource-limited communities. Additionally, increasing CESD-R score was related to higher pro-inflammatory markers. These results suggest that improving individuals’ neighborhood perceptions may be beneficial in improving the psychological well-being and, ultimately, CV health of urban minority residents.
Effect of tumor infiltrating lymphocytes (TILs) and stromal CD68 on trastuzumab (T) benefit in early stage HER2 positive breast cancer (BC).
Authors: Jacques Raphael, Inna Y Gong, Sharon Nofech-Mozes, John M. S. Bartlett, Houman Nafisi, Sunil Verma
Journal: Journal of Clinical Oncology (2015)

556 Background: The presence of high TILs has been implicated as a predictor of pathologic complete response (pCR) and decreased recurrence rates in BC patients. However, there is conflicting data for the benefit of T in the adjuvant setting for HER2 positive (HER2+) BC patients with high TILs. In addition, greater numbers of CD68 (+) cells (macrophage marker) in tumor stroma has been shown to be an independent prognosticator for reduced BC specific survival. Methods: Core biopsies from52 Her2+ BC patients treated with neoadjuvant (NAT) chemotherapy with or without T were identified. Two pathologists independently quantified stromal TILs and CD68 ratio (inside the TILs population) using Hematoxylin/Eosin and immunohistochemistry respectively. The association of TILs and CD68 with pCR rates was determined by Mann-Whitney U, Chi-square or Fisher’s exact test. Prognostic significance of TILs and CD68 ratio on pCR rates, disease free survival and overall survival (OS) was assessed by Kaplan-Meier analysis and log-rank test. Results: The median age and follow up for the cohort were 52 and 2.8 years, respectively. In the NAT setting, 40 patients received conventional chemotherapy and T (77%) and 12 patients were treated with chemotherapy alone (23%). Overall the pCR rate in the studied population was 40%. Eight patients (15%) had high levels of TILs ( ≥ 60%) and 20 patients (38%) had low CD68 ratio ( ≤ 60%). A high percentage of TILs was significantly correlated to low CD68 ratio (p < 0.0001). High levels of TILs and low CD68 ratio were each associated with greater pCR rates for the cohort of patients who received NAT T, respectively (p = 0.05, p = 0.03). Furthermore, pCR was predictive of better OS (p = 0.02) for the patients treated with NAT T. However, these associations were no longer significant when we performed the analysis on the whole population (p = 0.09, p = 0.32). Conclusions: Our results show that high levels of TILs are associated with low CD68 ratio, and both are predictors of pCR in patients with HER2+ BC receiving NAT T. Importantly, pCR as determined by CD68 and TILs translated into an OS benefit. TILs and CD68 ratio represent potential prognostic and predictive markers in patients with HER2+ BC.
A cytokine and angiogenic factor (CAF) analysis in plasma in testicular germ cell tumor patients (TGCTs).
Authors: Jozef Mardiak, Dana Cholujova, Igor Jurisica, Paulina Gronesova, Vera Miskovska, Jana Obertova, Patrik Palacka, Jan Rajec, Zuzana Sycova-Mila, Vanda Usakova, Bibiana Vertakova-Krakovska, Michal Chovanec, Daniela Svetlovska, Tomas Salek, Peter Bujdak, Stanislav Spanik, Dalibor Ondrus, Michal Mego
Journal: Journal of Clinical Oncology (2013)

e15599 Background: We investigated cytokines and angiogenic factors (CAFs) in patients with testicular germ cell tumors (TGCTs). We aimed to link the CAF profile to type of response to chemotherapy and select candidate prognostic and predictive markers for further study. Methods: In the presented study, plasma from 99 patients (pt) with TGCTs treated with first line (95 pt) or salvage (4 pt) chemotherapy was collected. The concentrations of 51 plasma CAFs were measured pre-treatment (n = 80) and on day 22 (n = 60) using multiplex bead arrays (Human Group I and II cytokine panels and TGF beta by Bio-Plex 200 system (Bio-Rad Laboratories, Hercules, CA). We used unsupervised clustering with self-organizing map (SOM) and k-means clustering to analyze CAF expression profiles. Results: Unsupervised clustering with self-organizing maps and k-means identified characteristic plasma cytokine profiles in different subgroups of patients according to response to chemotherapy and other clinical variables. Several cytokines were differentially expressed in patients with favourable and unfavorable response in serum before chemotherapy including IL-1b, IL-15, M-CSF, IL-4, IL-5, b-NGF, IL-10, MCP-3, FGF basic, IL-6, MIP-1a, GM-CSF, IL-17, IL-13, MIP1b, IL-8, SCF, IFN alfa, SCGFb, IL-2RA, IP-10, IL-16, TGFb-3. Similarly, following cytokines were differentially expressed in serum after 1 st cycle of chemotherapy IL-1b, TGFb-3, LIF, TGFb-2, IL-16, IL-18, IL-2RA, MCP-3, IFN alfa, HGF, IL1a, MIF, SCF, IL-3, SCGFb, b-NGF, MIG, CTACK. Conclusions: CAF profiling with unsupervised clustering revealed clinically relevant differences in subgroups of TGCTs patients. We suggest that this platform may provide valuable insights into TGCTs biology, and could help to identify plasma cytokine signature for predicting treatment resistance.
Abstract P276: Subjective versus Objective Measures of Sleep: Results From an Ecological Momentary Assessment Study
Authors: Christopher C Imes, Christopher E Kline, Dara D Mendez, Ran Sun, Yu Yang, Eileen R Chasens, Stephen L Rathbun, Lora E Burke
Journal: Circulation (2019)

Introduction: Reliable and valid measures are essential in research; however, it remains unclear if self-reported sleep measures are concordant with objective measures. Purpose: To examine the associations between subjective and objective sleep duration and awakenings among adults enrolled in a behavioral weight loss study. Methods: Self-report data included responses to the questions “How many hours of sleep did you get?” and “Number of awakenings?” collected each morning by ecological momentary assessment. Objective measures included actigraphic data on sleep duration and awakenings collected for 7 days at 6 and 12 mos. Concordance between measures was examined using linear mixed models predicting self-report measures of sleep from objectively measured sleep. Results: The sample (N = 137) was 89.8% female and 81.8% white with a mean age of 51.5 ± 9.9 yrs. Based on self-report, sleep duration was 417.2 ± 77.7 min./night with 1.7 ± 1.5 awakenings. Based on actigraphy, sleep duration was 413.1 ± 79.5 min./night with 33.0 ± 14.1 awakenings. The fitted model for sleep duration yielded an estimated intercept of 197.3 min. (95% CI, 178.0, 216.6) and slope of 0.54 (95% CI, 0.49, 0.58). In the scatter plot of self-report against objective sleep (Fig 1a), the plotted points were well-scattered about the 45-degree line suggesting that self-report min. of sleep predicted objective min. of sleep. The fitted model for awakenings yielded an estimated intercept of 0.95 awakenings (95% CI, 0.66, 1.2) and slope of 0.02 (95% CI, 0.015, 0.028). In the scatter plot of self-report against objective awakenings (Fig 1b), all of the plotted points fell below the 45-degree line indicating that self-report drastically underestimated actigraphic awakenings. Conclusion: Self-reported sleep duration was a good indicator of objective sleep duration, while self-reported awakenings significantly underestimated actigraphic awakenings. Sleep is multi-dimensional and both subjective and objective measures are needed to capture its various features.
Five versus six fractions per week radiotherapy in squamous cell carcinoma of head and neck in elderly patients.
Authors: Shweta Baral
Journal: Journal of Clinical Oncology (2015)

e17001 Background: Concomitant accelerated radio-chemotherapy was compared with conventional radio-chemotherapy in elderly patients with squamous cell carcinoma of head and neck with the hypothesis that acceleration of radiation by one week without dose reduction will have better loco-regional control and acceptable toxicities. Methods: In this study, 36 patients, median age of 65 years with diagnosis of squamous cell carcinoma of head and neck were enrolled. Patients were equally divided into two arms, one with accelerated fractionation (six fractions per week) and other with conventional fractionation. Planned radiotherapy dose was 66-70 Gy and both groups received concomitant chemotherapy Cisplatin weekly (40 mg/m2) with radiation if indicated. In accelerated fractionation group sixth fraction of radiotherapy was given on weekends. Acute toxicities were noted and loco-regional control was analyzed 8 weeks after completion of treatment. Results: 95%of enrolled patients received planned treatment. Median dose of radiation in both arms was 70 Gy (10-76 Gy). 2 patients in accelerated group defaulted treatment, one after 10 Gy and other after 18 Gy. Median duration of treatment in accelerated group was 52 days (41-74 days) and conventional group was 58 days (50-72 days). Treatment interruptions were longer in accelerated group with a median 7 days (2-30 days) versus median 6 days (2-19 days) in conventional group. Loco-regional control with complete remission was better in accelerated fractionation group (66.6% vs 41.1%, p = 0.12). Acute grade III and IV toxicities were significantly higher in accelerated group , odynophagia (61.1% vs 16.6%,p = 0.008), mucositis (72.2% vs 22.2%, p = 0.003) and other toxicities xerostemia (55.5% vs 22.2%, p = 0.043), dermatitis (22.2 vs 5.5%, p = 0.169), dysphagia (61.1% vs 33.3%, p = 0.091) were also higher but not statistically significant. Conclusions: In elderly patients, concomitant accelerated radiotherapy is more effective as compared with concomitant conventional fractionation in terms of complete remission rate but at a cost of significantly high rate of acute toxicities leading to increase treatment interruptions and treatment related morbidities.
HER2/neu-directed therapy for biliary tract cancer.
Authors: Humaid Obaid Al-Shamsi, Christian Daniel Barrera, Rakesh Surapaneni, HyunSeon Kang, Rachna T. Shroff, Filip Janku, Sunil Krishnan, Mingxin Zuo, Robert A. Wolff, Ahmed Omar Kaseb, Melanie B. Thomas, Abby B. Siegel, Milind M. Javle
Journal: Journal of Clinical Oncology (2015)

e15137 Background: Biliary cancers are highly aggressive tumors that are often diagnosed an advanced disease stage and have a poor outcome with systemic therapy. Recent efforts towards molecular characterization have identified a subset of biliary patients that have HER2/neu amplification or mutation. HER2/neu amplification is associated with response to HER2/neu-directed therapy in breast and gastric cancer. However, the efficacy of HER2/neu targeted therapy in biliary cancers is unknown. Methods: We retrospectively reviewed cases of advanced gallbladder cancer and cholangiocarcinoma with HER2/neu genetic aberrations or protein overexpression who received HER2/neu-directed therapy between 2007-2014. Clinical data were retrieved from medical records; and imaging studies were independently reviewed. Results: Nine patients with gallbladder cancer and 5 patients with cholangiocarcinoma had received HER2/neu-directed therapy (trastuzumab, lapatinib or pertuzumab) during the study period. In the gallbladder cancer group, HER2/neu gene amplification or overexpression was detected in 8 cases. These patients experienced disease stability (n = 3), partial response (n = 4) or complete response (n = 1) with HER2/neu-directed therapy. One patient had HER2/neu mutation and experienced a mixed response after lapatinib therapy. The duration of response varied from 8+ to 168 weeks (median 40 weeks) and 3 patients are still on therapy. One patient developed HER2/neu amplification as a secondary event after FGFR-directed therapy for FGF3-TACC3 gene fusion. The cholangiocarcinoma cases treated in this series had a higher proportion of HER2/neu mutations and no radiological responses were seen in these patients despite HER2/neu-directed therapy. Conclusions: HER2/neu blockade is a promising treatment strategy for gallbladder cancer patients with gene amplification and deserves further exploration in a multi-center study.
Abstract P183: The Multiple Measurements of Urinary Sodium-to-Potassium Ratio Strongly Related With Home Hypertension: the Tohoku Medical Megabank Project Cohort Study
Authors: Mana Kogure, Takumi Hirata, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Ken Miyagawa, Hiroshi Koshimizu, Taku Obara, Hirohito Metoki, Akira Uruno, Masahiro Kikuya, Junichi Sugawara, Shinichi Kuriyama, Atsushi Hozawa
Journal: Circulation (2019)

Introduction: Recently, the balance between sodium and potassium intake, i.e. sodium-to-potassium (Na/K) ratio, has received a lot of attention for prevention of hypertension. Previous studies reported that the positive association between 24-hour urinary Na/K (uNa/K) ratio and hypertension. However, no studies have evaluated the relationship between uNa/K ratio measured by casual urine measurement and home hypertension in large populations. We aimed to clarify whether casual uNa/K ratio using the self-monitoring device was associated with home hypertension in general population. In addition, we assessed whether multiple days measurement of uNa/K ratio by casual urine increase the accuracy of the prediction of home hypertension compared with casual urine collected in a single day. Hypothesis: We assessed the hypothesis that multiple measurement of uNa/K ratio was positively associated with home hypertension, and increase the prediction of home hypertension compared with a single measurement. Methods: The subjects were over 20 years old who participated in The Tohoku Medical Megabank Project Cohort Study. Of these participants, we targeted 2,551 subjects who borrowed home blood pressure monitors (HEM-7080IC) and uNa/K ratio monitors (HEU-001F) for continuous 10 days. To assess the relationship between casual uNa/K ratio and home hypertension, we performed multiple logistic regression analyses and calculated aOR with 95% CI. We included covariate factors as age, sex, BMI and drinking status. In addition, to compare the prediction of home hypertension in multiple measurement with that in a single measurement, we calculated area under the ROC curve (AUROC) of uNa/K ratio. Home hypertension was defined as a SBP ≥ 135 mmHg and/or a DBP ≥ 85 mmHg. Results: Among 849 subjects had home hypertension (33.3%). Although uNa/K ratio was even positively associated with home hypertension by a single day (P for trend &lt;0.01, aOR of home hypertension increase per quartile =1.11), the relationship between uNa/K ratio of multiple measurement and home hypertension was more robust (aOR of more than 5 days: 1.23 to 1.25). Similarly, AUROC of uNa/K ratio measurement for home hypertension in 5 days was larger than that in a single day. Conclusions: In conclusion, even single measurement of uNa/K ratio was positively associated with hypertension, the multiple measurement of uNa/K ratio strongly related with home hypertension. We suggested that multiple measurement of uNa/K ratio is desirable for assessing home hypertension because long term measurement of uNa/K ratio might reflect participants’ dietary balance of Na/K ratio.
Kindlin-2 Is Essential for Preserving Integrity of the Developing Heart and Preventing Ventricular Rupture
Authors: Zhiyuan Zhang, Yongxin Mu, Jianlin Zhang, Yangzhao Zhou, Paola Cattaneo, Jennifer Veevers, Angela K. Peter, Ana Maria Manso, Kirk U. Knowlton, Xinmin Zhou, Sylvia M. Evans, Robert S. Ross, Ju Chen
Journal: Circulation (2019)
Long-term outcomes for radiotherapy alone verse combined chemoradiotherapy for patients with stage II nasopharyngeal carcinoma in the era of intensity-modulated radiotherapy.
Authors: Man Hu, Fan Pingping, Fan Bingjie, Zhang Guoli, Liu Xijun, Yu Jinming
Journal: Journal of Clinical Oncology (2015)

6054 Background: The use of chemotherapy (CT) in the treatment of stage II nasopharyngeal carcinoma (NPC) is controversial. And the reports especially about intensity-modulated radiotherapy (IMRT) have been limited. The purpose of this study is to evaluate the long-term survival outcomes for stage II NPC treated with radiotherapy alone verse combined chemoradiotherapyin the era of IMRT. Methods: We reviewed records between January 2002 and December 2013 and identified 182 patients who were histologically diagnosed as stage II NPC received RT with or without CT in Shandong Tumor Hospital. Among these patients, 52 were restaged T2N0M0 and the other 130 were restaged T1-2N1M0. One hundred and fifty-nine (38 in T2N0M0 and 121 in T1-2N1M0) received RT with CT (RT/CT) and 23 (14 in T2N0M0 and 9 in T1-2N1M0) underwent RT alone. The overall survival (OS), progression-free survival (PFS), locoregional failure-free survival (LRFF), and disease metastasis-free survival (DMF) were calculated with Kaplan-Meier method. Results: With a median follow-up of 63.6 months (range 9.4 to 145.7), the 3-year, 5-year and 10-year OS of all stage II patients were 93.2%, 87.5% and 65.4%. For patients with staged T2N0M0, the corresponding rates were 92.3%, 89.9%, 82.6% and for those with T1-2N1M0, they were 93.6%, 86.6%, and 63.2%, respectively. No significant difference in OS, PFS, LRFF and DMF were observed between RT/CT group and RT alone group (p = 0.217, 0.768, 0.340 and 0.415, respectively). All locoregional recurrence occurred in the first 3 years and all distant metastases were developed in patients staged T1-2N1M0, referring more aggressive therapy such as chemotherapy may be indicated for these patients. Conclusions: This is the largest cohort of patients with stage II NPC in the era of IMRT with long follow-up. Chemotherapy showed no additional benefit for patients with stage II NPC. Patients staged T2N0M0 had an excellent outcome treated with RT alone. And for those staged T1-2N1M0 who had a higher risk for distant metastasis, additional chemotherapy may be perferred.