tbuckley/cabot-search huggingface dataset:
AB1120 DIAGNOSTIC ROLE OF NEUROMUSCULAR ULTRASOUND IN CUBITAL TUNNEL SYNDROME
Authors: Fatma Ali, Mona Nasr, Ahmed Hafez, Adham Khalil
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> Cubital tunnel syndrome (CuTS) is the second most common compressive neuropathy of the upper limb following carpal tunnel syndrome and is the most common site for entrapment for the ulnar nerve <h3>Objectives</h3> Our aim is to evaluate the role of ultrasonography (US) as a diagnostic tool for Cubital tunnel syndrome (CuTS) in comparison with nerve conduction study (NCS). Methods: twenty elbows with CuTS and twenty asymptomatic controls were assessed by NCS and underwent ultrasonography of elbows. Data from patients and controls were compared to determine the diagnostic relations in patients with CuTS and the grade of severity <h3>Results</h3> There was a high degree of correlation between NCS of the ulnar nerve, clinical parameters and variable US measurements. The CSA of the ulnar nerve was the most sensitive parameter and a cut-off point of 9.5 mm<sup>2</sup> behind medial epicondyle was found to be 100% sensitive and 80% specific. The ulnar nerve ratios (UNR) had a diagnostic accuracy of 95% with 85% specificity. <h3>Conclusion</h3> Ultrasonographic measurements of the ulnar nerve CSA and UNR have a comparable diagnostic value as a non-invasive and an alternative modality for the evaluation of CuTS <h3>References</h3> [1] Simon N, Ralph J, Poncelet A, Engstrom J, Chin C, Kliot M. A comparison of ultrasonographic and electrophysiologic inchingin ulnar neuropathy at the elbow. Clin Neurophysiol. 2015;126(2):391-398. [2] Omejec G, Podnar S. Normative values for short-segment nerve conduction studies and ultrasonography of the ulnar nerve at the elbow. Muscle nerve. 2015;51(3):370-377. [3] Yoon J, Walker F, Cartwright M. Ultrasonographic swelling ratio in the diagnosis of ulnar neuropathy at the elbow. Muscle nerve. 2008;38(4):1231-1235. [4] Bayrak A, Bayrak I, Turker H, Elmali M, Nural M. Ultrasonography in patients with ulnar neuropathy at the elbow: Comparison of cross-sectional area and swelling ratio with electrophysiological severity. Muscle nerve. 2010;41(5):661-666. <h3>Disclosure of Interests</h3> None declared
Abstract 16315: Association Between Diabetes and Health Status Outcomes in Young Women and Men After Acute Myocardial Infarction: Results From the VIRGO Study
Authors: Qinglan Ding, Marjorie Funk, Erica S Spatz, Robin Whittemore, Haiqun Lin, Kasia J Lipska, Rachel P Dreyer, John A Spertus, Harlan M Krumholz
Journal: Circulation (2018)

Introduction: Diabetes increases the risk of mortality after acute myocardial infarction (AMI). However, little is known about the association of diabetes and health status outcomes (symptoms, func...
PB2105 RESULTS OF BONE DENSITOMETRY IN PATIENTS WITH MULTIPLE MYELOMA DURING TREATMENT
Authors: A. Sergey, V. Troyan, K. Sergey, O. Rukavitsyn
Journal: HemaSphere (2019)

Background: Multiple myeloma is a malignant tumor consisting of plasma cells, with infiltration which increases bone resorption, increases the activity of osteoclasts, changes bone mineral density in the form of osteopenia and osteoporosis Aims: to evaluate and compare bone density over time in patients with multiple myeloma after high‐dose chemotherapy with autotransplantation of hematopoietic stem cells. Methods Prior to treatment, all patients (n = 64) were densitometry of the spine, both hip joints in a direct projection and repeated after 7‐12 months (m = 10). The results were evaluated by the T‐test in the values of standard deviations (SD): norm (+ 2.5SD&gt; ‐1SD); osteopenia (&lt;‐1SD&gt; ‐2.5SD); osteoporosis &lt;‐2.5SD. The results of densitometry in patients with multiple myeloma were compared before and after high‐dose chemotherapy with autotransplantation of hematopoietic stem cells, and patients who received standard chemotherapy. Results: Before treatment, the data of densitometry in the group of patients with chemotherapy (n = 35): in 12 (34.2%) patients the norm (‐0.425 ± 0.078SD); 18 (54.4%) patients had osteopenia (‐1.633 ± 0.056 SD); in 5 (14.2%) osteoporosis (‐2.62 ± 0.033 SD). In the group of patients with stem cell transplantation (n = 29), the following results were obtained: the norm (‐0.4 ± 0.145 SD) in 8 (27.5%) people; osteopenia (‐1.831 ± 0.071 SD) ‐ in 16 (55.1%) patients; osteoporosis (‐2.68 ± 0.033 SD) ‐ in 5 (17.4%) people. In the statistical analysis, the median MTF of both groups was m = ‐1.6SD. After the treatment, 10–12 months later, in the control group with chemotherapy (n = 35), the changes were less pronounced: the norm (–0.467 ± 0.077 SD) in 12 (34.2%) patients; in 18 (54.4%) patients with osteopenia (‐1.472 ± 0.056 SD); osteoporosis (‐2.7 ± 0.063 SD) in 5 (14.2%) people. In the group of patients with transplantation after the treatment, the indicators were as follows: T‐criterion is within normal limits (–0.137 ± 0.135 SD); osteopenia (‐1.83 ± 0.071 SD) osteoporosis (‐2.64 ± 0.022 SD). When analyzing the changes in the density level in each specific patient before and after treatment using the Student's t‐criterion, it turned out that in the group with high‐dose chemotherapy, the dynamics of the increase in the density level were significantly better in the groups of patients with initially normal and osteoporotic groups (= 5.77; (p &lt;0.001) and t = 2.45; (p &lt;0.01), respectively, in the studied groups). Summary/Conclusion: After high‐dose chemotherapy with autotransplantation of hematopoietic stem cells, the mineral density of bone tissue increases significantly, which can be assessed by densitometric studies.
Sequence and Structural Diversity of Mouse Y Chromosomes
Authors: Andrew P Morgan, Fernando Pardo-Manuel de Villena
Journal: Molecular Biology and Evolution (2017)

Over the 180 My since their origin, the sex chromosomes of mammals have evolved a gene repertoire highly specialized for function in the male germline. The mouse Y chromosome is unique among mammalian Y chromosomes characterized to date in that it is large, gene-rich and euchromatic. Yet, little is known about its diversity in natural populations. Here, we take advantage of published whole-genome sequencing data to survey the diversity of sequence and copy number of sex-linked genes in three subspecies of house mice. Copy number of genes on the repetitive long arm of both sex chromosomes is highly variable, but sequence diversity in nonrepetitive regions is decreased relative to expectations based on autosomes. We use simulations and theory to show that this reduction in sex-linked diversity is incompatible with neutral demographic processes alone, but is consistent with recent positive selection on genes active during spermatogenesis. Our results support the hypothesis that the mouse sex chromosomes are engaged in ongoing intragenomic conflict.
The role of mobile health technologies in allergy care: An EAACI position paper
Authors: Paolo Maria Matricardi, Stephanie Dramburg, Alberto Alvarez‐Perea, Darío Antolín‐Amérigo, Christian Apfelbacher, Marina Atanaskovic‐Markovic, Uwe Berger, Michael S. Blaiss, Simon Blank, Elisa Boni, Matteo Bonini, Jean Bousquet, Knut Brockow, Jeroen Buters, Victoria Cardona, Jean‐Christoph Caubet, Özlem Cavkaytar, Tania Elliott, Ignacio Esteban‐Gorgojo, Joao A. Fonseca, James Gardner, Philippe Gevaert, Ileana Ghiordanescu, Peter Hellings, Karin Hoffmann‐Sommergruber, A. Fusun Kalpaklioglu, Farid Marmouz, Ángela Meijide Calderón, Ralph Mösges, Alla Nakonechna, Markus Ollert, José Oteros, Giovanni Pajno, Catalina Panaitescu, Daniel Perez‐Formigo, Oliver Pfaar, Constantinos Pitsios, Michael Rudenko, Dermot Ryan, Silvia Sánchez‐García, Jennifer Shih, Salvatore Tripodi, Lauri‐Ann Van der Poel, Harmieke van Os‐Medendorp, Gilda Varricchi, Jörn Wittmann, Margitta Worm, Ioana Agache
Journal: Allergy (2019)

Abstract Mobile health (mHealth) uses mobile communication devices such as smartphones and tablet computers to support and improve health‐related services, data and information flow, patient self‐management, surveillance, and disease management from the moment of first diagnosis to an optimized treatment. The European Academy of Allergy and Clinical Immunology created a task force to assess the state of the art and future potential of mHealth in allergology. The task force endorsed the “Be He@lthy, Be Mobile” WHO initiative and debated the quality, usability, efficiency, advantages, limitations, and risks of mobile solutions for allergic diseases. The results are summarized in this position paper, analyzing also the regulatory background with regard to the “General Data Protection Regulation” and Medical Directives of the European Community. The task force assessed the design, user engagement, content, potential of inducing behavioral change, credibility/accountability, and privacy policies of mHealth products. The perspectives of healthcare professionals and allergic patients are discussed, underlining the need of thorough investigation for an effective design of mHealth technologies as auxiliary tools to improve quality of care. Within the context of precision medicine, these could facilitate the change in perspective from clinician‐ to patient‐centered care. The current and future potential of mHealth is then examined for specific areas of allergology, including allergic rhinitis, aerobiology, allergen immunotherapy, asthma, dermatological diseases, food allergies, anaphylaxis, insect venom, and drug allergy. The impact of mobile technologies and associated big data sets are outlined. Facts and recommendations for future mHealth initiatives within EAACI are listed.
OP0256 IN MEDIUM TO LONG-TERM JUVENILE DERMATOMYOSITIS, PROINFLAMMATORY AND PROFIBROTIC CYTOKINES ARE DIFFERENTLY ASSOCIATED WITH PULMONARY INVOLVEMENT IN ACTIVE VS INACTIVE DISEASE
Authors: Henriette Marstein, Thomas Schwartz, Trond M Aaløkken, May Britt Lund, Berit Flatø, Ivar Sjaastad, Helga Sanner
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> Knowledge about associations between cytokines and lung involvement in juvenile dermatomyositis (JDM) is scarce. <h3>Objectives</h3> To examine associations between cytokines and pulmonary involvement in JDM assessed after medium to long-term follow-up. <h3>Methods</h3> 58 JDM patients examined median 17y after disease onset were stratified in active and inactive disease by the updated PRINTO criteria (Ref 1). Serum levels of cytokines were analyzed by Luminex or ELISA. Pulmonary function tests (PFT) included forced vital capacity (FVC), total lung capacity (TLC) and diffusing capacity for carbon monoxide (DLCO) (hgb adjusted). PFT variables are expressed as% of predicted. High resolution computed tomography (HRCT) scans were scored for interstitial lung disease (ILD), calcinosis in chest wall and airway disease. Associations between lung involvement and cytokines are presented as Spearman's correlation coefficient (r<sub>s</sub>). <h3>Results</h3> No significant differences were found between active and inactive patients in tbl.?1. Associations between cytokines and PFT/HRCT findings Numbers are r<sub>s</sub>, all p's &lt; 0.05 In patients total, TGFb1 and PDGF correlated with TLC and FVC (- 0.38 - -0.30). For TGFb1 correlations with TLC and FVC were - 0.62 and -0.59 in the inactive group, whereas PDGF correlated with FVC in the active group (- 0.48). IP-10 correlated with TLC in active patients only (- 0.35). In patients total and active patients, eotaxin correlated with DLCO% (0.39 and 0.52). In inactive patients, MIP1b correlated with DLCO% (0.47). In patients total, IP-10 correlated with any HRCT finding and airways disease (0.37 and 0.44); which were also present in active patients (0.34 and 0.61). In patients total, MCP-1 correlated with any HRCT finding and calcinosis (0.34 and 0.40); in active patients MCP-1 and calcinosis correlated (0.34). Eotaxin correlated with ILD in both patients total and active patients (0.37 and 0.38). The following cytokines correlated with HRCT findings in inactive patients only; IL-17 with any HRCT findings and ILD (0.61 and 0.52), MIP1a with any HRCT findings (0.63) and IL-5 with ILD (-0.42). <h3>Conclusion</h3> In JDM, lung involvement was associated with mainly proinflammatory cytokines in active and profibrotic/proinflammatory cytokines in inactive patients. The association between higher eotaxin and better gas diffusion was interesting, since we have previously demonstrated an association between higher eotaxin and cardiac dysfunction (Ref 2). <h3>References</h3> [1] Almeida, A&amp;R 2015;67(9) [2] Schwartz, Rheumatology, 2014;53(12) <h3>Disclosure of Interests</h3> None declared
Abstract 19396: Diuretic Use Guided by a Wireless Implanted Pulmonary Artery Pressure Monitoring System in NYHA Class III Heart Failure Patients: Observations from the CHAMPION Trial
Authors: Maria Rosa Costanzo, Philip B Adamson, William T Abraham, Bradley Jeffries, Susan Neville, Pam Cowart, John Henderson, Jay S Jadav
Journal: Circulation (2012)

Introduction: Optimal diuretic dosing strategies for the treatment of chronic heart failure (HF) have not been established. The range of effective diuretic doses varies widely from patient to patient and within patient from time to time. Knowledge of wirelessly measured Pulmonary Artery Pressure (w-PAP) can provide immediate feedback on treatment response and thus may help identify an optimal diuretic strategy. Methods: Retrospective analysis of CHAMPION trial data to determine if adjustments of diuretic therapy in response to w-PAP are associated with reduced HF hospitalization rates. Results: In the CHAMPION trial 270 patients were assigned to w-PAP and 280 to usual care (UC). At baseline w-PAP and UC groups were similar in percentage of patients receiving diuretics (91.9% and 94.2%) and diuretics doses. Over a 6 month follow up period loop diuretics were more frequently adjusted in the w-PAP than in the UC group (1267 vs. 498 times; p&lt;0.0001). In the w-PAP group 629 diuretic adjustments (49.8%) in 155 patients (57.4%) resulted from detection of increases in PAP and 107 diuretic changes (75.4%) in 46 patients (17%) occurred after detection of declining PAP. Compared to baseline, 6 months daily loop diuretic dose increased from 96.8 mg to 122.7 mg in the w-PAP group and 98.0 mg to 112.4 in the UC group. Despite more frequent diuretic adjustments in the w-PAP than in the UC group, mean daily loop diuretic dose changes were similar between groups (25.9 mg vs. 14.3 mg; p=0.1214). The 89 w-PAP patients with increased loop diuretic dose had a lower rate of HF hospitalizations than the 68 UC patients with similarly increased diuretic doses (0.32 vs. 0.70; p= 0.0014. In contrast HF hospitalization rates were similar in the 134 w-PAP and 173 UC patients without diuretic dose change (0.28 vs.0.27). Conclusions: Utilization of w-PAP permits physicians to effectively increase and decrease diuretic doses and reduce HF hospitalizations rates. Such adjustments in diuretic doses without knowledge of w-PAP are associated with a high 6-month rate of HF hospitalizations.
Some Prompt and Delayed Effects of X Rays on Growth of Human Amnion Cells (Strain FL) in Tissue Culture
Authors: Henry I. Kohn, Jørgen E. Fogh
Journal: JNCI Journal of the National Cancer Institute (1959)

Journal Article Some Prompt and Delayed Effects of X Rays on Growth of Human Amnion Cells (Strain FL) in Tissue Culture Get access Henry I. Kohn, Henry I. Kohn Radiological Laboratory4University of California School of Medicine, San Francisco, California, and Virus Laboratory,5University of California, Berkeley, California Search for other works by this author on: Oxford Academic PubMed Google Scholar Jørgen E. Fogh Jørgen E. Fogh Radiological Laboratory4University of California School of Medicine, San Francisco, California, and Virus Laboratory,5University of California, Berkeley, California Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 23, Issue 2, August 1959, Pages 293–304, https://doi.org/10.1093/jnci/23.2.293 Published: 01 August 1959 Article history Received: 25 January 1959 Published: 01 August 1959
Cultural Innovations Influence Patterns of Genetic Diversity in Northwestern Amazonia
Authors: Leonardo Arias, Roland Schröder, Alexander Hübner, Guillermo Barreto, Mark Stoneking, Brigitte Pakendorf
Journal: Molecular Biology and Evolution (2018)

Human populations often exhibit contrasting patterns of genetic diversity in the mtDNA and the nonrecombining portion of the Y-chromosome (NRY), which reflect sex-specific cultural behaviors and population histories. Here, we sequenced 2.3 Mb of the NRY from 284 individuals representing more than 30 Native American groups from Northwestern Amazonia (NWA) and compared these data to previously generated mtDNA genomes from the same groups, to investigate the impact of cultural practices on genetic diversity and gain new insights about NWA population history. Relevant cultural practices in NWA include postmarital residential rules and linguistic exogamy, a marital practice in which men are required to marry women speaking a different language. We identified 2,969 SNPs in the NRY sequences, only 925 of which were previously described. The NRY and mtDNA data showed different sex-specific demographic histories: female effective population size has been larger than that of males through time, which might reflect larger variance in male reproductive success. Both markers show an increase in lineage diversification beginning ∼5,000 years ago, which may reflect the intensification of agriculture, technological innovations, and the expansion of regional trade networks documented in the archaeological evidence. Furthermore, we find similar excesses of NRY versus mtDNA between-population divergence at both the local and continental scale, suggesting long-term stability of female versus male migration. We also find evidence of the impact of sociocultural practices on diversity patterns. Finally, our study highlights the importance of analyzing high-resolution mtDNA and NRY sequences to reconstruct demographic history, since this can differ considerably between sexes.
PS1347 PHF19 INDUCES EZH2 PHOSPHORYLATION AND PROMOTES DRUG RESISTANCE IN MULTIPLE MYELOMA
Authors: C.‐X. Du, T.‐T. Yu, L.‐T. Liu, J. Xu, Z.‐Q. Li, Z. Yu, F.‐H. Zhan, X.‐K. Ma, L.‐G. Qiu, M. Hao
Journal: HemaSphere (2019)

Background: Multiple myeloma (MM) is a plasma cell malignancy characterized by consecutive progression and increased invasion. It is becoming increasingly evident that tumor development and the acquisition of drug resistance involves the alteration of epigenetic regulation. PcG (polycomb group) proteins are key to epigenetic repression through two main complexes, PRC1 (Polycomb repressive complex 1) and PRC2. PHF19, also known as PCL3, combines with histone methyltransferase EZH2 (Enhancer of Zeste 2) and participates in the formation of PRC2 complex. Our study is the first report that depicts the role of PHF19 in the drug resistance of MM, providing new therapeutic choices for these patients. Aims: To disclose the role of PHF19 in promoting drug resistance of multiple myeloma and explore the therapeutic strategy based on the mechanism research. Methods: RNA‐seq data from 351 newly‐diagnosed patients, 44 MGUS, 12 SMM and 22 healthy plasma cells reported the role of PHF19 as an independent risk predictor for survival. We then studied the functional role of PHF19 by overexpression or shRNA knockdown in ARP1 and OCI‐My5 MM cell lines, conducting cell proliferation counting, Annexin V/7AAD assay for apoptosis, and mouse xenograft experiments. Gene expression profile was performed in ARP1 MM cell line. Western blot was used to investigate the expression of the potential targets of PHF19. Dual luciferase assay was used to reveal the relation between miR‐15a and PHF19 mRNA. Results: PHF19 was associated to high‐risk and dismal outcome of MM patients. It promoted cell growth and resistance to bortezomib both in vitro and in vivo. PHF19 activated the bypass of canonical PRC2 function by recruiting AKT to phosphorylate EZH2, which released the expression of HIF‐1α, Bcl‐xL and Mcl‐1. PI3K inhibitor LY294002 reversed the upregulation of the mentioned pro‐survival proteins. miR‐15a bound to 3’UTR of PHF19 mRNA to negatively regulate its expression. Summary/Conclusion: PHF19 is correlated to disease progression and drug resistance of MM. In vitro and in vivo experiments reveal PHF19 significantly promotes cell survival and inhibites apoptotic activity. PI3K/AKT signaling pathway is highly involved in the function of PHF19, indicating inhibition of PI3K/AKT may be an effective strategy to treat those patients with high level of PHF19.
Differential expression of Plg-RKT and its effects on migration of proinflammatory monocyte and macrophage subsets
Authors: Barbara Thaler, Nagyung Baik, Philipp J. Hohensinner, Johanna Baumgartner, Adelheid Panzenböck, Stefan Stojkovic, Svitlana Demyanets, Ihor Huk, Gersina Rega-Kaun, Christoph Kaun, Manfred Prager, Michael B. Fischer, Kurt Huber, Walter S. Speidl, Robert J. Parmer, Lindsey A. Miles, Johann Wojta
Journal: Blood (2019)
AB0572 INVASIVE MYCOSES IN PATIENTS WITH CONNECTIVE TISSUE DISEASE FROM SOUTHERN CHINA: CLINICAL FEATURES AND ASSOCIATED FACTORS
Authors: Dongying Chen, zhongping zhan
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> Invasive fungal disease (IFD) was well studied in patients with AIDS and organ transplant recipients. A few researches illustrated that patients with connective tissue disease (CTD) were also predisposed to IFD. However, few researches were designed to focus on invasive mycosis (IM) in patients with CTD. <h3>Objectives</h3> To investigate the clinical features and associated factors of IM in patients with CTD from Southern China. <h3>Methods</h3> A retrospective study CTD was performed. Demographic and clinical data were recorded. Associated factors were analyzed by logistic regression analysis. <h3>Results</h3> A total of 32 patients with CTD were included. The incidence of IM was 0.5% in patients with CTD (32/6911) and the highest in patients with ANCA-associated vasculitis (AAV) (7/480, 1.5%). Molds were isolated in 20 sputum specimens (20/29, 69.0%). <i>Aspergillus</i> spp. (81.3%) were the leading strain. Positivity of serum G-test and GM-test was 47.8% (11/23) and 34.6% (9/26), respectively. GM-test was positive in BALF from seven patients. Lung was commonly involved (30/32, 93.8%). Pulmonary nodules (46.7%) and cavitary lesions (36.7%) were common. Ten patients died (31.3%), including three with AAV (42.9%) and seven with SLE (36.8%). Multivariate logistic regression analysis showed that lymphopenia [odds ratio (OR) =3.28, 95% confidential interval (CI) 1.29-8.38, <i>P</i>=0.01] and median-to-high dose of glucocorticoid (GC) [OR=3.40, 95% CI 1.04-11.13, <i>P</i>=0.04] was associated with IM in patients with CTD. Patients with lymphopenia experienced higher risk of co-infection (50.0% <i>vs</i> 0%, <i>P</i>=0.01) and mortality (45.5% <i>vs</i> 0%, <i>P</i>=0.01) compared with patients with normal lymphocyte count. <h3>Conclusion</h3> IM tended to develop in patients with AAV, resulting in high mortality. Sputum culture could be an effective and non-invasive method to diagnose IM. Lymphopenia, and median-to-high dose of GC are associated with IM in patients with CTD. Acknowledgement: no <h3>Disclosure of Interests</h3> None declared