tbuckley/cabot-search huggingface dataset:
Clinical Entity and Outcomes of Therapy-Related Chronic Myeloid Leukemia in the Era of Tyrosine Kinase Inhibitors: Surveillance By the Chronic Myeloid Leukemia Cooperative Study Group
Authors: Noriyoshi Iriyama, Tomoiku Takaku, Eriko Sato, Maho Ishikawa, Tomonori Nakazato, Kei-Ji Sugimoto, Hiroyuki Fujita, Michihide Tokuhira, Tatsuya Kawaguchi
Journal: Blood (2016)
In Chronic Lymphocytic Leukemia ΔCT7544-7545 Mutant NOTCH1 Maintains Transcription Factor Activity with Longer Lasting Effects Due to Slower Degradation
Authors: Jennifer Edelmann, Tetyana Klymenko, Chen Lu, Emma Vilventhraraja, Sven Estenfelder, Eugen Tausch, Stephen A Beers, Stephan Stilgenbauer, Mark S Cragg, Andrejs Ivanov, John Gribben
Journal: Blood (2016)
Impact of Ethnicity and Socioeconomic Status on Outcome of Unrelated Donor (URD) Hematopoietic Cell Transplantation (HcT).
Authors: K. Scott Baker, Anna Hassebroek, Karen Ballen, Carolyn Bigelow, Haydar Frangoul, Cheryl Hardy, Stephanie Lee, Galen Switzer, J. Douglas Rizzo, John P. Klein, Navneet Majhail, Stella Davies
Journal: Blood (2007)
Incidence and Risk Factors for Central Venous Catheter-Related Venous Thromboembolism in Breast Cancer Patients Under Neoadjuvant Chemotherapy: the Caveccas (Catheter Veineux Central et Cancer du Sein) Study
Authors: Philippe Debourdeau, Marc Espié, Sylvie Chevret, Joseph Gligorov, Antoine Elias, Pierre Francois Dupré, Joel Le Long, Sandrine Lavau-Denes, Marie-Antoinette Sevestre, Laurent Bastit, Issa Kalidi, Corinne Frere, Dominique Farge
Journal: Blood (2016)
Models of the Gut for Analyzing the Impact of Food and Drugs
Authors: Chiara Anna Maria Fois, Thi Yen Loan Le, Aaron Schindeler, Sina Naficy, Dale David McClure, Mark Norman Read, Peter Valtchev, Ali Khademhosseini, Fariba Dehghani
Journal: Advanced Healthcare Materials (2019)

Models of the human gastrointestinal tract (GIT) can be powerful tools for examining the biological interactions of food products and pharmaceuticals. This can be done under normal healthy conditions or using models of disease-many of which have no curative therapy. This report outlines the field of gastrointestinal modeling, with a particular focus on the intestine. Traditional in vivo animal models are compared to a range of in vitro models. In vitro systems are elaborated over time, recently culminating with microfluidic intestines-on-chips (IsOC) and 3D bioengineered models. Macroscale models are also reviewed for their important contribution in the microbiota studies. Lastly, it is discussed how in silico approaches may have utility in predicting and interpreting experimental data. The various advantages and limitations of the different systems are contrasted. It is posited that only through complementary use of these models will salient research questions be able to be addressed.
A Phase 2 Study of Panobinostat (PAN) in Combination with Bortezomib (BTZ) in Patients with Relapsed/Refractory Peripheral T-Cell Lymphoma (PTCL) or NK/T-Cell Lymphoma (NKL)
Authors: Yeow-Tee Goh, William YK Hwang, Colin Phipps Diong, Yap chun Hsien, Kevin Tay, Soon Thye Lim, Yuh Shan Lee, Soo Chin Ng, S Fadilah, Won Seog Kim, Daryl Tan
Journal: Blood (2014)
Role of diffusional kurtosis imaging in grading of brain gliomas: A diagnostic test accuracy systematic review and meta-analysis
Authors: Gehad Abdalla, Eser Sanverdi, Pedro M Machado, Joey S W Kwong, Jasmina Panovska-Griffiths, Antonio Rojas-Garcia, Daisuke Yoneoka, Tarek Yousry, Sotirios Bisdas
Journal: Neuro-Oncology (2019)

Abstract Aim and objectives We aim to illustrate the diagnostic performance of diffusional kurtosis imaging (DKI) in the diagnosis of gliomas. Methods and materials A review protocol was developed according to the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols (PRISMA-P), registered in the international prospective register of systematic reviews, PROSPERO and published. Literature search in 4 databases was performed using the keywords “glioma” and “diffusional kurtosis”.After applying a robust inclusion/exclusion criteria, included articles were independently evaluated according to the QUADAS-2 tool.Data extraction was done in a pre-designed pro forma.Reported sensitivities and specificities were used to construct 2x2 tables and paired forest plots using the Review Manager (RevMan®) software.Random-effect model was pursued using the hierarchical summary receiver operator characteristics. Results Initially, 216 hits were retrieved. Considering duplicates and inclusion criteria; 23 articles were eligible for full-text reading. Ultimately, 19 studies were deemed to be eligible for final inclusion. Quality assessment revealed 9 studies with low risk of bias in the 4 domains. Using a bivariate random-effect model for data synthesis; summary ROC curve showed pooled area under the curve (AUC) of 0.92 and estimated sensitivity of 0.87 (95% CI: 0.78 - 0.92) in high/low grade gliomas’ differentiation.A mean difference in Mean Kurtosis (MK) value between HGG and LGG of 0.22 [95% CI: 0.25 - 0.19] was illustrated (p value = 0.0014) and a moderate degree of heterogeneity (I²= 73.8%). Conclusion DKI shows good diagnostic accuracy in high/low grade gliomas’ differentiation; which might qualify it to be part of the routine clinical practice, however; further evidence is deemed for technique standardization.
Bone Marrow Mesenchymal Stem Cell (BM-MSC) Release Microvesicles/Exosomes That Incorporate Into Hematopoietic Cells From MDS Patients and May Modify Their Behaviour
Authors: Sandra Muntión, Post Doc Fellowship, Teresa Ramos, Bruno Paiva, Beatriz Roson, Maria Eugenia Sarasquete, Maria Diez-Campelo, Maria Teresa Rejas, Marcos González, Jesus F San Miguel, Fermin Sanchez-Guijo, Maria-Consuelo del Cañizo
Journal: Blood (2013)
A Novel Role of Histone Deacetylase 11 (HDAC11) in the Regulation of IL-10 Production and Immune Tolerance Mediated by Antigen-Presenting Cells.
Authors: Hongwei Wang, Fengdong Cheng, D. Nguyen, I. Suarez, K. Wright, A.P. Atadja, E. Seto, K. Bhalla, A. Villagra, E.M. Sotomayor
Journal: Blood (2007)
Type II Inhibition of JAK2 with NVP-CHZ868 Reverses Type I JAK Inhibitor Persistence and Demonstrates Increased Efficacy in MPN Models
Authors: Sara C Meyer, Matthew D Keller, Priya Koppikar, Olga A Guryanova, Maria Kleppe, Anna Sophia McKenney, William R Sellers, Francesco Hofmann, Fabienne Baffert, Christoph Gaul, Thomas Radimerski, Ross L Levine
Journal: Blood (2014)
Incidence of Autoimmune Cytopenias (AIC) in Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma (CLL/SLL) Patients (pts) Treated with Ibrutinib
Authors: Kerry A. Rogers, Jennifer A. Woyach, Leslie A. Andritsos, Farrukh Awan, Kristie A. Blum, Joseph M Flynn, Samantha Jaglowski, Gerard Lozanski, Kami J. Maddocks, John C. Byrd, Jeffrey A. Jones
Journal: Blood (2014)
Phase I Study of CD8 Memory T-Cell Donor Lymphocyte Infusion for Relapse of Hematologic Malignancies Following Matched Related Donor Allogeneic Hematopoietic Cell Transplantation
Authors: Lori S. Muffly, Kevin Sheehan, Randall Armstrong, Keri Tate, Cynthia Tudisco, Andrew R. Rezvani, David Miklos, Sally Arai, Judith Shizuru, Laura Johnston, Everett Meyer, Wen-Kai Weng, Ginna G. Laport, Robert S Negrin, Sam Strober, Robert Lowsky
Journal: Blood (2016)
Osteopontin - A New Angiogenic Factor Which Correlates with Circulating Endothelial Cells in Acute Myeloid Leukemia.
Authors: Agnieszka Wierzbowska, Magdalena Czemerska, Anna Krawczyńska, Agnieszka Pluta, Anna Szmigielska, Anna Wolska, Tadeusz Robak
Journal: Blood (2009)
Re: Lorenzo Marconi, Thomas Stonier, Rafael Tourinho-Barbosa, et al. Robot-assisted Radical Prostatectomy After Focal Therapy: Oncological, Functional Outcomes and Predictors of Recurrence. Eur Urol 2019;76:27–30
Authors: Giancarlo Marra, Roland Van Velthoven, Massimo Valerio
Journal: European Urology (2019)
Autologous Hematopoietic Stem Cell Transplantation Overcomes Primary Refractory Disease in Multiple Myeloma Patients Treated with Novel Agents
Authors: Gunjan L Shah, Meier Hsu, Sean Devlin, David J Chung, Hani Hassoun, Guenther Koehne, Neha S Korde, Nikoletta Lendvai, Alexander M. Lesokhin, Ola Landgren, Heather Landau, Sergio A. Giralt
Journal: Blood (2015)
DNA-Microarray for Simultaneous Detection of Herpesviruses and Adenovirus in Patients Undergoing Allogeneic Stem Cell Transplantation.
Authors: Anette K. Ditzen, Anke Rutzka, Markus Stichling, Rene Mueller, Ralf Ehricht, Thomas Illmer, Martin Bornhaeuser, Enno Jacobs, Jacques Rohayem
Journal: Blood (2006)
Erythroblasts From Polycythemia Vera Patients Express the Dominant negative β Isoform of the Glucocorticoid Receptor.
Authors: Lilian Varricchio, Antonella Di Noia, Elena Alfani, Emilia Stellacci, Angela Battistini, Angela di Baldassarre, Giovanni Migliaccio, Alessandro M. Vannucchi, Damiano Rondelli, Ronald Hoffman, Anna Rita Migliaccio
Journal: Blood (2009)
KPT-SINE, a Potent, Small Molecule Inhibitor of CRM1-Dependent Nuclear-Cytoplasmic Shuttling, with Potent Activity Against T-ALL and AML
Authors: Julia Etchin, Alex Kentsis, Takaomi Sanda, Andrew L. Kung, Richard M. Stone, Dilara McCauley, Michael Kauffman, Sharon Shacham, Thomas Look
Journal: Blood (2011)
Relationship Between Patient-Reported Outcomes (PROs) and Health-Related Quality of Life (HRQoL) and Efficacy in Patients with Myelofibrosis in the Phase III Persist-1 Trial of Pacritinib Vs. Best Available Therapy (BAT)
Authors: Ruben A. Mesa, Claire N. Harrison, Francisco Cervantes, James P. Dean, Lixia Wang, Tanya Granston, Yoojung Yang, Alessandro M. Vannucchi, Adam Mead
Journal: Blood (2015)
Follow-Up Results of a Prospective, Multicenter, Open-Label Study of Oral Fludarabine Phosphate in Patients with Previously Untreated B-CLL.
Authors: Jean-Francois Rossi, A. Van Hoof, K. De Boeck, S. A. Johnson, D. Bron, C. Foussard, T. A. Lister, M. H.H. Kramer, T. J. Littlewood, R. E. Marcus, E. Deconinck, O. Guibon, M. Montillo, S. M. Tollerfield
Journal: Blood (2005)
An uncommon etiology of pancreatitis after endoscopic ultrasound-guided fine needle aspiration
Authors: Osvaldo Burattini, Giuseppe Losurdo, Stefania Marangi, Margherita Curlo, Mauro Mastronardi, Pietro Giorgio, Antonio Pisani
Journal: Endoscopy (2019)

An 82-year-old man was referred to our unit with a pancreatic mass. A computed tomography scan had demonstrated a 6-cm solid lesion in the body-tail region of the pancreas, with local lymph node involvement, highly suggestive of malignancy ([Fig. 1]). Endoscopic ultrasound (EUS) was then performed (Olympus GF-UCT 180; Olympus Medical, Tokyo, Japan). The solid mass, located at the distal pancreatic body ([Fig. 2]) showed irregular margins and splenic vein infiltration. Fine needle aspiration (FNA) using a 19-gauge needle (Olympus EZ Shot 3 plus) was performed for four passes, with a final histopathological diagnosis of “mucinous adenocarcinoma.”
Molecular Characterization of SRSF2 Mutation Identifies a Clinically Relevant Lncrna (MALAT1) in Chronic Myelomonocytic Leukemia (CMML)
Authors: Maria E. Balasis, Jane Merelvede, Sateesh Kunigal, Xiaoyi Ren, Yan Ma, Qing Zhang, Jeff Painter, Nathalie M. Droin, Joseph Johnson, Sean Yoder, Rami S. Komrokji, Ling Zhang, Sheng Wei, Torsten Haferlach, Robert MacLeod, Alan F. List, Eric Solary, P.K. Epling-Burnette, Eric Padron
Journal: Blood (2015)
Next-Generation Sequencing (NGS) in CMML, MDS and AML Detects Molecular Mutations in Oncogenes and Allows the Identification of Balanced Chromosomal Abnormalities with Extraordinary Sensitivity and Specificity.
Authors: Vera Grossmann, Alexander Kohlmann, Claudia Haferlach, Hans-Ulrich Klein, Martin Dugas, Frank Dicker, Beray Kazak, Sonja Schindela, Susanne Schnittger, Wolfgang Kern, Torsten Haferlach
Journal: Blood (2009)
Immunomodulation of Both Donors and Recipients with Atorvastatin As a Strategy for the Prevention of Acute Graft-Versus-Host Disease (aGVHD): Results of Two Parallel Prospective Trials in Recipients of Matched Sibling Allogeneic Hematopoietic Cell Transplantation (alloHCT)
Authors: Mehdi Hamadani, Michael Craig, Scot Remick, Laura Gibson, William Petros, Jame Abraham, Aaron Cumpston, Pamela Bunner, Soumit Basu, William Tse, Carrie Hennelly, Sumithira Vasu, Rebecca B Klisovic, William Blum, Samantha M. Jaglowski, Don M. Benson, Leslie A Andritsos, Sam Penza, Craig C. Hofmeister, Susan Geyer, Steven M. Devine, Yvonne A Efebera
Journal: Blood (2012)
Azacytidine Compromises NK-Cell Activity in AML and MDS Patients Undergoing MRD-Based Pre-Emptive Treatment After Allogeneic Stem Cell Transplantation
Authors: Katja Sockel, Claudia Schönefeldt, Sieghart Sopper, Martin Wermke, Marc Schmitz, Gerhard Ehninger, Martin Bornhäuser, Dominik Wolf, Uwe Platzbecker
Journal: Blood (2012)
Initial Remission Duration of Less Than 1 Year Is No Longer An Adverse Prognostic Factor for Patients with Relapsed HL Undergoing High Dose Therapy and Autologous Stem Cell Transplant: Results of a Combined Analysis From Two Large Transplant Centers.
Authors: Alison J. Moskowitz, John Sweetenham, Brian J. Bolwell, Jocelyn C Maragulia, Jill M Vanak, Craig H Moskowitz, Stephen Smith
Journal: Blood (2009)
Allogeneic Hematopoietic Stem Cell Transplantation for Multiple Myeloma: Evolution and Outcomes over More Than Two Decades within EBMT Centers
Authors: Mauricette Michallet, Mohamad Sobh, Simona Iacobelli, Anja van Biezen, Peter Dreger, Eefke Petersen, Nicolaas PM Schaap, Giuseppe Bandini, Liisa Volin, Ellen Meijer, Dietger Niederwieser, Hermann Einsele, Didier Blaise, Reza Tabrizi, Laure Vincent, Jurgen Finke, Donald Bunjes, Jan J. Cornelissen, Gosta Gahrton, Laurent Garderet, Nicolaus Kroger
Journal: Blood (2014)
Alloimmune Effect May Improve Survival of De Novo Myelodysplastic Syndrome After allogeneic hematopoietic cell transplantaion: A Single Center Analysis of 115 Patients
Authors: Nobuhiro Hiramoto, Kinuko Tajima, Saiko Kurosawa, Takuya Yamashita, Kenji Okinaka, Noriyuki Morikawa, Kohei Tada, Takashi Tanaka, Ryosuke Ueda, Yujin Kobayashi, Akihito Shinohara, Sung-Won Kim, Shin-ichiro Mori, Yuji Heike, Takahiro Fukuda
Journal: Blood (2011)
Efficacy, Safety and Long Term Results of Prophylactic and Preemptive Donor Lymphocyte Infusion after Allogeneic Stem Cell Transplantation for Acute Leukemia: A Registry-Based Evaluation on 343 Patients By the Acute Leukemia Working Party of EBMT
Authors: Christoph Schmid, Myriam Labopin, Hendrik Veelken, Nicolaas P.M. Schaap, Michael Schleuning, Michael Stadler, Juergen Finke, Yves Beguin, Matthew Collin, Per T. Ljungman, Gesine Bug, Didier Blaise, Johanna Tischer, Adrian Bloor, Boris Afanasyev, Sebastian Giebel, Norbert Claude Gorin, Jordi Esteve, Fabio Ciceri, Bipin N. Savani, Frederic Baron, Audrey Mailhol, Arnon Nagler, Mohamad Mohty
Journal: Blood (2015)
Characteristics and prognosis of leptomeningeal metastasis in patients with breast cancer
Authors: Yurina Maeshima, Yoshinori Ito, Tomoko Shibayama, Mari Hosonaga, Makiko Ono, Kokoro Kobayashi, Takayuki Kobayashi, Takayuki Ueno, Masahiko Oguchi, Syunji Takahashi, Shinji Ohno
Journal: Annals of Oncology (2019)
Myeloid Blastic Transformation of Myeloproliferative Neoplasms – A Review of 113 Cases.
Authors: Syed Noor, Wei Tan, Gregory Wilding, Laurie Ann Ford, Maurice Barcos, Sheila N.J. Sait, AnneMarie W. Block, James E. Thompson, Eunice S. Wang, Meir Wetzler
Journal: Blood (2009)
An Engineered Cell Surface Polypeptide for Selection, Tracking and Ablation of Genetically Modified Hematopoietically Derived Cells Based on Human EGFR.
Authors: Xiuli Wang, Wen-Chung Chang, ChingLam W Wong, David Colcher, Mark Sherman, Julie R Ostberg, Stanley R. Riddell, Stephen Forman, Michael C Jensen
Journal: Blood (2010)
Safety and Efficacy of Enoxaparin Prophylaxis in Adults Receiving Peg-Asparaginase Containing Induction Regimens for Acute Lymphoblastic Leukemia (ALL)
Authors: Jayadev Manikkam Umakanthan, Lori J. Maness, Jiangtao Luo, Avyakta Kallam, James O. Armitage, Philip Bierman, Julie M. Vose, R. Gregory Bociek, Matthew Lunning, Krishna Gundabolu, Vijaya R. Bhatt
Journal: Blood (2016)
Melphalan and Dexamethasone Plus Bortezomib Induces Hematologic and Organ Responses in AL-Amyloidosis with Tolerable Neurotoxicity.
Authors: Jeffrey A Zonder, Vaishali Sanchorawala, Rachel M. Snyder, Jeffrey Matous, Howard Terebelo, Nalini Janakiraman, Markus Y Mapara, Silvana Lalo, Nishant Tageja, Craig Webb, David Monsma, Catherine Sellers, Judith Abrams, Cristina Gasparetto
Journal: Blood (2009)
Decitabine Improves Response Rate and Prolongs Progression Free Survival in Older Patients with Newly Diagnosed Acute Myeloid Leukemia with Monosomal Karyotype: A Subgroup Analysis of the Daco-16 Trial
Authors: Agnieszka Wierzbowska, Ewa Wawrzyniak, Agnieszka Pluta, Tadeusz Robak, Grzegorz J. Mazur, Anna Dmoszynska, Jaroslav Cermak, Albert Oriol, Farhad Ravandi, Hagop M. Kantarjian
Journal: Blood (2015)
Adoptive Immunotherapy with Tregs Prevents GvHD and Favours Immune Reconstitution After HLA Haploidentical Transplants for Hematological Malignancies.
Authors: Mauro Di Ianni, Franca Falzetti, Alessandra Carotti, Adelmo Terenzi, Elisabetta Bonifacio, Yair Reisner, Andrea Velardi, Franco Aversa, Massimo F Martelli
Journal: Blood (2009)
Intrinsic Requirement of MicroRNA In Hox-Based Leukemia Initiating Cell Maintenance
Authors: Aditya Chaubey, Chinavenmeni Subramani Velu, Shane Horman, Anil Jegga, Monica L. Guzman, Nancy Zeleznik-Le, Craig T. Jordan, Martin Carroll, Brian Gebelein, H. Leighton Grimes
Journal: Blood (2010)
Clinical Significance of FLT3/ITD and NPM1 Mutation in Acute Myeloid Leukemia (AML).
Authors: Rikio Suzuki, Makoto Onizuka, Masako Shimada, Yasunobu Iwaki, Hiroshi Kawada, Yoshiaki Ogawa, Tomomitsu Hotta, Kiyoshi Ando
Journal: Blood (2006)
Nivolumab for poor performance status patients : retrospective analysis
Authors: Toshihiko Matsumoto, Shogo Kimura, Hitomi Himei, Ukyo Okazaki, Yusuke Kurioka, Takao Tsuduki, Shijiro Takagi, Masahiro Takatani, Takanori Watanabe, Hirofumi Morishita
Journal: Annals of Oncology (2019)
Ofatumumab (OFA) Is a Novel Anti-CD20 Monoclonal Antibody (mAb) with Improved Anti-Tumor Activity in Vitro and in Vivo in Mantle Cell Lymphoma (MCL) Pre-Clinical Models.
Authors: Matthew J. Barth, Gopichand Pendurti, Ping-Chiao Tsai, Cory Mavis, Pavel Klener, Myron S. Czuczman, Francisco Hernandez-Ilizaliturri
Journal: Blood (2012)
Comparative Analysis of Hematopoiesis Supporting Capacity and Matrix Remodeling of Bone Marrow Stromal Cells Isolated From Patients with Myeloproliferative Neoplasms.
Authors: Rebekka K Schneider, Isabelle Leisten, Susanne Ziegler, Anne Schumacher, Dirk Fahrenkamp, Gerhard Mueller-Newen, Martina Crysandt, Edgar Jost, Ruth Knuechel, Tim H Brümmendorf, Patrick Ziegler
Journal: Blood (2012)
Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells
Authors: Eric H. Ma, Mark J. Verway, Radia M. Johnson, Dominic G. Roy, Mya Steadman, Sebastian Hayes, Kelsey S. Williams, Ryan D. Sheldon, Bozena Samborska, Penelope A. Kosinski, Hyeryun Kim, Takla Griss, Brandon Faubert, Stephanie A. Condotta, Connie M. Krawczyk, Ralph J. DeBerardinis, Kelly M. Stewart, Martin J. Richer, Victor Chubukov, Thomas P. Roddy, Russell G. Jones
Journal: Immunity (2019)
Cyclin-Dependent Kinase 4/6 Inhibitor Abemaciclib Exerts Dose-Dependent Cytostatic and Cytocidal Effects on Multiple Myeloma Cells Via Autophagy
Authors: Noriyoshi Iriyama, Hirotsugu Hino, Shota Moriya, Masaki Hiramoto, Yoshihiro Hatta, Masami Takei
Journal: Blood (2016)
Cytokine and T-Cell Phenotypic Changes Upon In Vivo Ibrutinib Therapy For CLL – Targeting Both CLL Cells and The Tumor-Microenvironment
Authors: Carsten U Niemann, Angelique Biancotto, Betty Y. Chang, Joseph J. Buggy, J. Philip McCoy, Mohammed Farooqui, Adrian Wiestner
Journal: Blood (2013)
Proliferation and Activation Patterns of Naïve, Memory and Regulatory T Cells in Patients with Multiple Myeloma During Thalidomide, Interferon-α and Bortezomib Maintenance Therapy.
Authors: Michael Hundemer, Isabelle Herth, Tobias Meissner, Dirk Hose, Anthony D Ho, Kai Neben, Hartmut Goldschmidt, Mathias Witzens-Harig
Journal: Blood (2009)
Efficacy of early controlled motion of the ankle compared with immobilisation in non-operative treatment of patients with an acute Achilles tendon rupture: an assessor-blinded, randomised controlled trial
Authors: Kristoffer Weisskirchner Barfod, Maria Swennergren Hansen, Per Hölmich, Morten Tange Kristensen, Anders Troelsen
Journal: British Journal of Sports Medicine (2019)

Background Early controlled motion (ECM) of the ankle is widely used in the non-operative treatment of acute Achilles tendon rupture, although its safety and efficacy have not been investigated properly in a randomised set-up. Purpose/Aim of the study To investigate if ECM of the ankle was superior to immobilisation in the treatment of acute Achilles tendon rupture. Materials and methods This was an assessor-blinded, randomised controlled trial with patients allocated in a 1:1 ratio to one of two parallel groups. Patients aged 18–70 years were eligible for inclusion. The ECM group performed movements of the ankle five times a day from week 3 to week 8 after rupture. The control group was immobilised for 8 weeks. The primary outcome was the Achilles tendon Total Rupture Score (ATRS) evaluated at 1-year postinjury. The secondary outcomes were heel-rise work test (HRW), Achilles tendon elongation and rate of rerupture. Analysis was conducted as intention-to-treat using inverse probability weighting. Findings/Results 189 patients were assessed for eligibility and 130 were included from February 2014 to December 2016. There were 64 patients in the ECM group and 58 in the immobilisation group. There were no statistically significant differences (p&gt;0.3) between the ECM and the immobilisation groups at 1 year: mean (SD) ATRS was 74 (18) and 75 (18), respectively. HRW was 60% (21) and 60% (21) of the uninjured limb, and elongation was 18 mm (13) and 16 mm (11), respectively. Correspondingly, there were six and seven reruptures. Conclusions ECM revealed no benefit compared with immobilisation in any of the investigated outcomes. Trial registration number NCT02015364
Successful Treatment of Thrombocytopenia with Staphylococcal Protein A (PRTX-100) in a Murine Model of Immune Thrombocytopenia (ITP)
Authors: John W. Semple, Edwin R. Speck, Rukhsana Aslam, Michael Kim, Anne Zufferey, Heyu Ni, Michelle Catalina, Richard Francovitch
Journal: Blood (2015)