tbuckley/cabot-search huggingface dataset:
AB1406-HPR Relationship between knee muscle strength, pain and functional outcomes in patients with patellofemoral osteoarthritis
Authors: H Guney Deniz, F. Tan, B. Atilla
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Knee Osteoartritis (OA) is one of the most common musculoskeletal disorders that adversely affect the functional levels of the patients. Traditionally, knee OA is considered as a problem at the medial compartment of the tibiofemoral (TF) joint. However, OA in patellofemoral (PF) joint can be seen around%25 of the patients. Since the biomechanics of PF joint are distinct from TF joint, the functional assessments specific to PF joint should be considered for PFOA patients. <h3>Objectives</h3> The aim of the study was to investigate the relationship between quadriceps femoris strength differences between PFOA patients and control group. Another aim was to define the relationship between pain, knee muscle strength, and functional outcomes in PFOA. <h3>Methods</h3> Twenty-five patients with PFOA (age=52.1 years, BMI=26.2 kg/cm<sup>2</sup>) and 20 age-matched controls (age=54.1 years, BMI=26.1 kg/cm<sup>2</sup>) were included in the study. The patients diagnosed with PFOA if they had a radiographic Kallgren and Lawrence score grade 2 or 3 in the PF joint, which was greater than KL score for the TF compartments. Pain level was measured with Visual Analogue Scale. The quadriceps femoris and hamstring isometric muscle strengths at 20° and 60° of knee flexion were measured with a hand-held dynamometer. The functional levels of the patients were determined with Kujala Patellofemoral Score and Western Ontario McMaster Universities Osteoartritis Index (WOMAC). Student t-test was used for the comparison of quadriceps strength between PFOA and control groups. Spearman correlation test was used to determine the relationship between pain, muscle strength and functional outcomes. <h3>Results</h3> The quadriceps strength at 20° (p=0.03) and 60° (p=0.01) of knee flexion were lower in PFOA group when compared to control group. Hamstring strength at both angles was similar between groups (p&gt;0.05). There were negative correlations between quadriceps muscle strength at 60° knee flexion and pain levels (r=−0.54, p=0.02) and total WOMAC score (r=−0.33, p=0.01). The quadriceps muscle strength at 20° knee flexion was only correlated with Kujala score (r=−0.47, p=0.01). There were no correlations between hamstring strength with pain and functional outcomes (p&gt;0.05). <h3>Conclusions</h3> PFOA patients had significantly lower quadriceps strength than control group. Pain level, quadriceps muscle strength and functional outcomes were associated with each other in patients with PFOA. These findings suggest that interventions that have been designed to reduce pain and to improve function should be specific to the affected compartment in knee OA. <h3>Reference</h3> [1] Hinman RS, Crossley KM. Patellofemoral joint osteoarthritis: an important subgroup of knee osteoarthritis. Rheumatology (Oxford). 2007;46(7):1057–62. <h3>Disclosure of Interest</h3> None declared
AB1070 Variations in the length of musculoskeletal temporary work disabilities in patients included in an early intervention program
Authors: A. Lois Iglesias, C. Bejerano, F.J. de Toro Santos
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Musculoskeletal disorders cause in Spain 23% of temporary work disability (TD) and they are the first cause of permanent work disability (PD). A study of early intervention (early assessment and immediate treatment by a rheumatologist) reduced TD days (39%) and evolution to PD (50%)<sup>1</sup>. Using the "Fit for Work" European coalition led by AbbVie, the program is implemented nationwide. <h3>Objectives</h3> The aim of this study is to analyse the variation in the number of days of sick leave in the patients included in an early intervention program comparing to usual average. <h3>Methods</h3> Observational cross-sectional study of a hospital cohort of outpatients referred during 18 consecutive months. The patients were referred for the first time to the Rheumatology Early Intervention consultation program because of temporary work disabilities due to musculoskeletal disorders. All of them received medical treatment; and underwent joints ultrasound, joint injections and learned exercises when needed. Patients whose disabilities were due to trauma or surgery were not included in the study. <h3>Results</h3> We evaluated 270 patients with a mean age of 48.9 years. 64% were women. The most frequently reported diseases were lumbar/sciatic pain (28.5%), shoulder pain (20%), neck pain (8%), knee pain (5.6%) and other arthralgias and tendinopathies (20%). All patients received medical treatment, 38.5% underwent ultrasound examination and 19,2% received joint injections. The pathologies with longest lengths of TD after the first visit to the rheumatologist were lumbar/sciatic pain (mean 40.6 days), neck pain (mean 33 days) and shoulder pain (mean 23.8 days). If we compare this data with the existent control group from San Carlos Hospital (Madrid), we can see a decrease of the days in sick leave of 29,5% in lumbar/sciatic pain (from 57.6 to 40.6 days), 11,7% in neck pain (from 37.4 to 33 days) and 36,3% in shoulder pain (from 37.4 to 23.8 days). <h3>Conclusions</h3> Early intervention by rheumatologists in patients with temporary work disability due to musculoskeletal disorders reduces the length of sick leaves. A quick diagnosis and assessment by specialists can improve the patient outcomes saving costs to health system. <h3>Reference</h3> [1] : Abasolo L, et al. A health system program to reduce work disability related to musculoskeletal disorders. Ann intern Med. 2005Sep 20; 143 (6):404–14. <h3>Disclosure of Interest</h3> None declared
Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity
Authors: Mattias N.D. Svensson, Karen M. Doody, Benjamin J. Schmiedel, Sourya Bhattacharyya, Bharat Panwar, Florian Wiede, Shen Yang, Eugenio Santelli, Dennis J. Wu, Cristiano Sacchetti, Ravindra Gujar, Gregory Seumois, William B. Kiosses, Isabelle Aubry, Gisen Kim, Piotr Mydel, Shimon Sakaguchi, Mitchell Kronenberg, Tony Tiganis, Michel L. Tremblay, Ferhat Ay, Pandurangan Vijayanand, Nunzio Bottini
Journal: Journal of Clinical Investigation (2019)

Genetic variants at the PTPN2 locus, which encodes the tyrosine phosphatase PTPN2, cause reduced gene expression and are linked to rheumatoid arthritis (RA) and other autoimmune diseases. PTPN2 inhibits signaling through the T cell and cytokine receptors, and loss of PTPN2 promotes T cell expansion and CD4- and CD8-driven autoimmunity. However, it remains unknown whether loss of PTPN2 in FoxP3+ regulatory T cells (Tregs) plays a role in autoimmunity. Here we aimed to model human autoimmune-predisposing PTPN2 variants, the presence of which results in a partial loss of PTPN2 expression, in mouse models of RA. We identified that reduced expression of Ptpn2 enhanced the severity of autoimmune arthritis in the T cell-dependent SKG mouse model and demonstrated that this phenotype was mediated through a Treg-intrinsic mechanism. Mechanistically, we found that through dephosphorylation of STAT3, PTPN2 inhibits IL-6-driven pathogenic loss of FoxP3 after Tregs have acquired RORγt expression, at a stage when chromatin accessibility for STAT3-targeted IL-17-associated transcription factors is maximized. We conclude that PTPN2 promotes FoxP3 stability in mouse RORγt+ Tregs and that loss of function of PTPN2 in Tregs contributes to the association between PTPN2 and autoimmunity.
AB0785 Red cell distribution width is a promising marker of pulmonary arterial hypertension in scleroderma-related disorders
Authors: M. Bellan, M. Sguazzotti, C. Piccinino, A. Giubertoni, J. Zanaboni, A. Dimagli, M. Gravellona, P. Marino, M. Pirisi, P.P. Sainaghi
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> The early identification of those Systemic Sclerosis (SSc) patients harbouring Pulmonary Arterial Hypertension (PAH) is a mainstay in the management of SSc. Novel biomarkers might improve the specificity of screening algorithms currently available. <h3>Objectives</h3> In this study we aimed to test the potential diagnostic value of Red cell distribution width (RDW), which has been previously described as a potential prognostic marker in thromboembolic and idiopathic PAH. <h3>Methods</h3> We prospectively recruited 118 patients affected by Scleroderma related disorders (Mixed connective tissue disease N. 7, 5.9%; SSc N. 93, 78.8%; Scleroderma overlap syndromes N. 11, 9.3%, undifferentiated connective tissue diseases N. 7, 5.9%) in a PAH outpatient clinic of a University Hospital. All patients underwent an extensive clinical and laboratory evaluation and an echocardiographic examination; a right heart catheterization was performed in 13 patients according to clinical indication. <h3>Results</h3> According to echocardiography and right heart catheterization, 14/118 patients were diagnosed with PAH. Patients affected by PAH had a higher RDW (15 [13.4–18.9] vs. 13.9 [12.1–19.1]; p=0.005), despite similar haemoglobin levels between groups. Patients affected by PAH also showed a higher BNP plasma concentration (245.6 [81.6–494.3] vs. 60.3 [50.3–77.4]; p=0.0001) and lower platelets count [206 188–243 × 10<sup>3</sup>/µl vs 240 [198–299] × 10<sup>3</sup>/µ; p=0.04]. RDW was also directly related to ultrasound-assessed Pulmonary Artery Pressure (PAPs) (ρ=0.20; p=0.03) and DLCO corrected for haemoglobin (ρ=−0.30; p=0.001); finally, RDW was related to the mean PAP measured by right heart catheterization (ρ=0.65; p=0.015). <h3>Conclusions</h3> RDW is an inexpensive, potentially useful marker in the detection of SSc-related PAH; its inclusion in screening algorithms could be considered to further improve their diagnostic performance. <h3>Disclosure of Interest</h3> None declared
Superior Risk Stratification With Coronary Computed Tomography Angiography Using a Comprehensive Atherosclerotic Risk Score
Authors: Alexander R. van Rosendael, Leslee J. Shaw, Joe X. Xie, Aukelien C. Dimitriu-Leen, Jeff M. Smit, Arthur J. Scholte, Jacob M. van Werkhoven, Tracy Q. Callister, Augustin DeLago, Daniel S. Berman, Martin Hadamitzky, Jeorg Hausleiter, Mouaz H. Al-Mallah, Matthew J. Budoff, Philipp A. Kaufmann, Gilbert Raff, Kavitha Chinnaiyan, Filippo Cademartiri, Erica Maffei, Todd C. Villines, Yong-Jin Kim, Gudrun Feuchtner, Fay Y. Lin, Erica C. Jones, Gianluca Pontone, Daniele Andreini, Hugo Marques, Ronen Rubinshtein, Stephan Achenbach, Allison Dunning, Millie Gomez, Niree Hindoyan, Heidi Gransar, Jonathon Leipsic, Jagat Narula, James K. Min, Jeroen J. Bax
Journal: JACC. Cardiovascular imaging (2019)
AB1418-HPR Low back pain and influence on the functional disability of the elderly population of manaus – amazonas, brazil: a cross – sectional study
Authors: I.M.B Souza, R.D.S P.Rodrigues, J.W.C. da Silva, L.R. Merini, S.L.K. Yuan, A.P. Marques
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Low back pain (LBP) is the primary cause of disability and absenteeism in the workplace, it is a complex multidimensional phenomenon with staggering social costs. These symptoms reduce functional capacity and limit both physical and psychosocial aspects of elderly life. <h3>Objectives</h3> To identify the influence of LBP on the functional disability in elderly subjects. <h3>Methods</h3> The study was approved by Research Ethics Committee of Medical School at University of Sao Paulo, Protocol.CAAE.56709716.5.1001.0065. This a cross-secional study, 700 community-dwelling elderly participated, both genders,≥60 years old, and functional disability was measured using the Rolland Morris Disability Questionnaire – Brazil version (RMDQ–BR). <h3>Results</h3> The punctual prevalence of LBP was 42.09%, age 68.61±6.06 years old, women 78.14%, and the functional disability score assessment was 11.26±6.07. About responses frequently items (RMDQ-BR) were: I change position frequently to try to get my back comfortable (84%); I avoid heavy jobs around the house because of my back (75%); Because of my back, I try not to bend or kneel down (73%); Because of my back, I go upstairs more slowly than usual (62%); I walk more slowly than usual because of my back. (57%); Because of my back, I use a handrail to get upstairs (55%). <h3>Conclusions</h3> The data demonstrates that there is a relationship between DL and functional disability in the elderly. It has been verified that the constant change to the maintenance of the posture, the decrease of the walking speed, to climb stairs with assistance, and the accomplishment of the activities of the daily that require movements of flexion trunk or knee have been reported to be difficult to perform. These data may be useful in the development of preventive strategies by health professionals that aim to encourage changes in routine care of daily living activities. <h3>References</h3> [1] Hicks GE, Gaines JM, Shardell M, et al<i>.</i>Associations of back and leg pain with health status and functional capacity of older adults: Findings from the retirement community back pain study. Arthrit Rheum-Arthr.2008Sep 15;59(9):1306–13. [2] Pereira LV, de Vasconcelos PP, Souza LAF, et al<i>.</i>Prevalence and intensity of chronic pain and self-perceived health among elderly people: a population-based study. Rev Lat-Am Enferm. 2014Jul-Aug;22(4):662–9. [3] Nusbaum L, Natour J, et al. Translation, adaptation and validation of the Roland-Morris questionnaire–Brazil Roland-Morris. Braz J Med Biol Res. 2001;34:203–10. <h3>Acknowledgements</h3> To Capes for the scholarship. <h3>Disclosure of Interest</h3> None declared
THU0427 Comparable cardiovascular disease and neoplasm rates but higher frequency of depression in systemic sclerosis versus rheumatoid arthritis: a multicentre comparative study of comorbidities
Authors: S. Panopoulos, M.G. Tektonidou, A. Drosos, S.-N. Liossis, T. Dimitroulas, L. Sakkas, D. Boumpas, P. Voulgari, D. Daoussis, K. Thomas, G. Georgiopoulos, G. Vosvotekas, D. Vassilopoulos, P.P. Sfikakis
Journal: Annals of the Rheumatic Diseases (2018)

images analysis led to classification of pulmonary segments as "negative" (normal morphology) and "positive" (GGO).Furthermore, the "Warrick score" was used as a staging tool for SSc-ILD.Mean Standardised Uptake Value (mSUV) of segmental parechima was normalised (nmSUV) by comparison with the values of selected control subjets.Results: No SSc patient was affected by cancer.Three patients had a Warrick Score >0, while 4 patients did not had any lung involvement (Warrick Score=0).The 3 patients with a Warrick Score >0 had also skin involvement with a median mRSS 6 (2-7) and pathological lung FDG uptake.In "positive" segments of SSc patients, nmSUV was significantly higher than in the lung segments of the control population (mean estimation 1.53; C.I. 1.42-1.65,p<0.0001).In "negative" segments of SSc patients, with a Warrick score >0, the nmSUV was significantly higher than in segments of the control population (mean estimation 1.29; C.I. 1.22-1.37,p<0.0001).Lung segments with GGO showed an nmSUV higher (21%) than "negative" segments (C.I. 0.13-0.28,p<0.0001) of patients with Warrick score >0."Negative" lung segments of patients with Warrick Score >0 showed a 32% higher 18F-FDG uptake than "negative" lung segments of patients with Warrick Score=0.(C.I. 0.17-0.48,p<0.0001).(figure 1) Abstract THU0425 -Figure 1. a) Differences in 18F-FDG uptake between "positive" segments of Warrick score >0 SSc patients, "negative" segments of Warrick score >0 SSc patients and "negative" segments of Warrick score=0 SSc patients vs attended normalised control value (=1); b) Differences in 18F-FDG uptake between "positive" lung segments of SSc patients with Warrick score>0 vs "negative" segments of the same patients; c) Differences in 18F-FDG uptake "negative" lung segments of patients with Warrick Score>0 vs "negative" lung segments of patients with Warrick Score=0 Conclusions: Morphologically "positive" GGO segments show an increased 18F-FDG uptake suggesting the existence of a metabolically active (inflammatory) GGO.However, in patients with GGO, negative lung segments showed a higher nmSUV than negative lung segments in patients without GGO.This may suggest that PET/CT may disclose an underlying inflammatory process, which cannot yet be evidenced by HRCT.Further studies on a larger population are warranted to confirm these data and possibly provide a prognostic significance of PET/CT positivity in SSc patients.
Association Between Invasive Lobular Breast Cancer and Mutations in the Mismatch Repair Gene <i>MSH6</i>
Authors: D. Gareth Evans, Sacha J. Howell, Juha Peltonen
Journal: JAMA Oncology (2019)

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AB1179 Musculoskeletal pattern of 18f-fdg uptake in patients with polymyalgia rheumatica
Authors: D. Prieto-Peña, J. Loricera, I. Martínez-Rodríguez, J. Banzo, M. Calderón-Goercke, V. Calvo-Río, C. González-Vela, M. González-Gay, J. Hernández, R. Blanco
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Polymyalgia rheumatica (PMR) is a common inflammatory rheumatic disease of the elderly whose diagnosis is usually based on clinical and ultrasound findings. Recently, <sup>18</sup>F-FDG PET/CT has been proposed as a promising one-step tool for assessing extent and severity of PMR. However, the pattern of <sup>18</sup>F-FDG uptake in PMR is not well established and there is a lack of imaging guidelines. <h3>Objectives</h3> Our aim was to describe the musculoskeletal pattern of <sup>18</sup>F-FDG uptake in PMR patients and assess if there were any differences between classic and atypical PMR. <h3>Methods</h3> Retrospective study of 75 patients with PMR and their respective PET/CT scans from a referral centre. We considered two groups: <b>a)</b> Classic PMR: patients who fulfilled the 2012 EULAR/ACR criteria; and <b>b)</b> Atypical PMR: patients with symptoms resembling PMR but did not fulfil the 2012 EULAR/ACR criteria. Distributions of categorical variables were compared by Pearson Chi2 or Fisher exact test as appropriate. <h3>Results</h3> We evaluated 75 patients (27 men and 48 women) with a mean age ±SD of 68.2±10.7 years. A PET/CT was performed in all of them. Forty-two (56%) patients classic PMR and 33 (44%) atypical PMR. FDG-PET uptake was observed in the following musculoskeletal regions: in shoulders (n=45), sternoclavicular joints (n=33), hips (n=32), cervical interspinous bursae (n=8), lumbar interspinous bursae (n=29), pubic symphysis (n=4), subtrochanteric bursae (n=20), ischial tuberosities (n=19) and knees (n=33). The comparative study between both groups is shown in the <b>TABLE</b>, without observing any statistical significance. <h3>Conclusions</h3> In patients with PMR, <sup>18</sup>F-FDG uptake seems to be more frequent in shoulders, sternoclavicular joints, hips and knees. In addition, <sup>18</sup>FDG uptake can be also detected in lumbar interspinous bursae and less frequently in subtrochanteric bursae, ischial tuberosities, cervical interspinous bursae and pubic symphysis. No differences between classic and atypical PMR patients were seen. <h3>Disclosure of Interest</h3> None declared
AB0233 Clinical and functional efficiency of large joins replacement in patients with high activity of rheumatoid arthritis
Authors: I. Akhtyamov, S. Lapshina, S. Ardashev, I. Gilmutdinov, L. Myasoutova
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> The synovium in rheumatoid arthritis (RA) produces a variety of cytokines that cause the destruction of articular cartilage, determining, in some cases, the need for replacement of the joint. Inflammatory substrate within the joint can be a source of high activity of RA. At the same time usually patients are taken to surgery only in the period of minimal activity of the disease. <h3>Objectives</h3> To evaluate the results of knee and hip joints replacement in patients with high RA activity and the quality of life of patients during the first year after the operation. <h3>Methods</h3> Replacement of knee and hip joints was performed in 36 patients (mean age 55.8±9.4 years) with high RA activity DAS28 (mean 5.53±0.67). At the time of surgery, the duration of the disease was 11.86±4.92 years, RF positive in 27 (75%) pts. At baseline, 30 (83.3%) patients were treated with DMARDs (methotrexate-25 (69.4%), leflunomide-3 (8.3%), sulfasalazine 2 (5.6%)), steroids (prednisolone in an average dose of 4.2±4.3 mg per day) −16 (44.4%) people, of whom, in combination with DMARDs – 8 (22.2%). The volume of therapy did not change after the operation. Biologics (infliximab, adalimumab, rituximab, etanercept) before surgery were given to 7 (19.4%) patients. Before the operation, after it, after 6 and 12 months, pain in the joints (VAS), activity of the disease – DAS28, functional capacity by the HAQ index was estimated. <h3>Results</h3> Reduction of VAS was observed already in the first month after surgery (47.3±18.6 mm), initially it was 72.6±14.2 mm, after 6 months it decreased 1.5 times to 48.7±11, 2 mm (p&lt;0.05), after 12 months – up to 29.8±10.3 mm (p&lt;0.05). After 6 months after surgery, the activity of the disease decreased reliably (p&lt;0.05) with DAS28 from 5.53±0.67 to 3.84±0.56; to 12 months DAS28- 3,24±0,61. Positive dynamics of functional ability was recorded according to the HAQ index: 1.74±0.25 before the operation, 1.64±0.28 in a month after, and 1.22±0.28 after 6 months (p&lt;0.05), after 1 year – 1,03±0,18 (p&lt;0,05). Complications after operations were not recorded. <h3>Conclusions</h3> Joints replacement in patients with high RA activity can be justified and effective in improving the functional ability and pain relief. Removal of pathologically altered joint tissues helps to reduce the activity of RA as a whole. <h3>Disclosure of Interest</h3> None declared
The Risk of Venous Thromboembolism Is High in Chronic Lymphocytic Leukemia Because of Additional Cancers: A Danish National Cohort Study
Authors: Inger Lise Gade, Signe Juul Riddersholm, Ilse Christiansen, Christian Torp-Pedersen, Søren Risom Kristensen, Marianne Tang Severinsen
Journal: Blood (2018)