Disulfiram Hepatotoxicity
Authors: HOWARD J. EISEN
Journal: Annals of Internal Medicine (1975)

Letters1 November 1975Disulfiram HepatotoxicityHOWARD J. EISEN, M.D., ALLEN L. GINSBERG, M.D.HOWARD J. EISEN, M.D.Search for more papers by this author, ALLEN L. GINSBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-5-673_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptKeeffe and Smith (1) recently reported a case of hepatotoxicity caused by disulfiram. Despite wide use of disulfiram for the treatment of alcoholism, hepatotoxic reactions had not previously been noted. Hepatotoxic reactions may be extremely rare; alternatively, drug-related hepatic disease may have been overlooked because of the high prevalance of alcoholic liver disease in the population treated with disulfiram. We describe a patient who developed severe hepatic dysfunction after two separate exposures to disulfiram.The patient is a 49-year-old black man with a history of chronic alcoholism. He has been in good health and had been hospitalized only once for...References1. KEEFFESMITH EF: Disulfiram hypersensitivity hepatitis. JAMA 230:435-436, 1974 CrossrefMedlineGoogle Scholar2. FEINSTONEKAPIKIANPURCELL SAR: Hepatitis A: detection by immunoelectron microscopy of a virus-like antigen associated with acute illness. Science 182:1026-1028, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Gastroenterology Department of Medicine George Washington University School of Medicine Washington, DC 20037 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDisulfiram: Side Effects and ToxicityClinical characteristics and prognostic markers in disulfiram-induced liver injuryDisulfiram-induced hepatitis. Report of four cases and review of the literatureAn exceptional case of lethal disulfiram-alcohol reactionHepatotoxicity of Diethyldithiocarbamate in RatsDisulfiram treatment of alcoholismDisulfiram Treatment of AlcoholismDisulfiram-Induced Hepatitis: Case Report and Review of the LiteratureCyanamide hepatotoxicity. Incidence and clinicopathological featuresLiver Toxicity Encountered in the Veterans Administration Trial of Disulfiram in AlcoholicsDisulfiram-induced hepatitisPharmacologic Treatment of Chronic AlcoholismDisulfiram-induced hepatitis--report of a case and review of the literature.Letter to the EditorArthritis and carpal tunnel syndrome associated with disulfiram (antabuse) therapyToxic Hepatitis Induced by Disulfiram in a Non-AlcoholicLiver cell injury (bodies similar to Lafora's) in alcoholics treated with disulfiram (Antabuse)Clinical Utilization of Alkaline Phosphatase MeasurementsDisulfiram HepatitisDrug Information Analysis ServiceMONOOXYGENASE CATALYZED ACTIVATION OF THIONO-SULFUR CONTAINING COMPOUNDS TO REACTIVE INTERMEDIATESMiscellaneous drugs 1 November 1975Volume 83, Issue 5Page: 673-675KeywordsAlcoholic liver diseaseAlcoholismDrugsLiver diseases Issue Published: 1 November 1975 PDF DownloadLoading ...