tbuckley/cabot-search huggingface dataset:
Abstract 15797: Peri-procedural Use of Novel Anticoagulation Agents During Cardiac Device Implantation
Authors: Jayasree Pillarisetti, Ryan Maybrook, Moustapha Atoui, Tulasi Annapureddy, Mamatha Vodapally, Luigi Di Biase, Carola Gianni, Andrea Natale, Dhanunjaya Lakkireddy
Journal: Circulation (2015)

Introduction: The timing of discontinuation and re-initiation of novel anticoagulant agents (NOACs) such as dabigatran, apixaban and rivaroxaban in the peri-procedural setting is important to minimize the risk of stroke and procedure-related bleeding. Methods: Consecutive patients who were on treatment with either dabigatran, rivaroxaban or apixaban and underwent a cardiac device generator change, upgrade or new implantation procedure at two high volume centers were noted (Group A). Age and gender matched patients on warfarin who underwent similar procedures were collected for controls (Group B). Patients were followed for three months for hematoma and other complications. Results: A total of 185 patients in group A underwent above procedures with new device implant in 50%, device upgrade in 23% and generator change in 25% of patients. There were 61 patients on dabigatran, 90 on rivaroxaban, 34 on apixaban in group A and 185 patients on coumadin in group B. Mean age of the total population was 68±12 years with 71% males and 84% Whites with no differences between groups. There were more patients on dual antiplatelet therapy in group A (10%) compared to group B (1%). Mean INR in Group B was 2.1 pre and post procedure. In 3 patients, NOACs were held for 24 to 48 hours prior to the procedure, while they were continued un-interrupted in the rest of the patients. NOACs were resumed after the procedure within 24 hours in all patients except in one patient. There was no difference noted in the incidence of minor or major hematoma in each of these groups (see table). None of the patients in Group A required evacuation. Two patients in Group B developed infection of the hematoma that prompted extraction of the device. No stroke or bleeding related complications were noted in both groups Conclusion: Uninterrupted use of the NOACs is safe in the peri-procedural setting during implantation of cardiac devices. Our study is the first to compare the three NOACs with warfarin.
Abstract 18578: Long-term Outcome of After Percutaneous Coronary Intervension for Ischemic Heart Disease Caused by Kawasaki Disease
Authors: Yusuke Koteda, Kenji Suda, Takafumi Ueno, Shintarou Kishimoto, Yoshiyuki Kagiyama, Yushirou Yamashita
Journal: Circulation (2016)

Introduction: The most important complication of Kawasaki disease (KD) is the coronary aneurysms and stenosis. Various types of percutaneous coronary intervention (PCI) have been successfully offer...
THU0030 Molecular mechanisms of autophagic memory in pathogenic t cells in human rheumatoid arthritis
Authors: P. Kumar, J.Y. Leong, S. Saidin, B. Paleja, J.V. Loosdregt, C. Chua, T. Arkachaisri, A. Consolaro, M. Gattorno, A. Martini, G.W. Williams, K.D Pischel, M. Lotz, S. Albani
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> One of the key elements of immune pathogenesis of human autoimmune arthritis is the resilience of pathogenic T cells. We have previously described that CD4 +T cells in patients with arthritis have an increased level of autophagy than their healthy equivalents. Here, we sought to explore at epigenetic and transcriptional levels the concept of persisting increased autophagy as the consequence of "autophagic memory", as one of the mechanisms conferring resilience to pathogenic T cells, in particular to a subset of CD4 +T cells (CPL: Circulating Pathogenic-like Lymphocytes), which are significantly more represented in patients with active arthritis and resistant to therapy with biologics <h3>Objectives</h3> To understand molecular mechanism of resilience and persistence in pathogenic T cells in rheumatoid arthritis. <h3>Methods</h3> Autophagy in T cells were analysed using CytoID autophagy detection kit. Jurkat cells pre-starved and control were harvested at various time points, and RNA was extracted for RNA-sequencing and DNA methylation analysis. Illumina paired end sequencing was performed and data was analysed using open source tools in R statistical programming software. CD4 +memory and naive T cells were sorted using flow cytometer for qPCR analysis. The CD4 +memory and naive cells were sorted using Flow cytometer. RNA extracted and converted to cDNA for qPCR analysis of key genes <h3>Results</h3> First, we demonstrated elevated autophagic levels in CD4 +memory T cells when compared to naive CD4 +T cells. Second, we showed that autophagic levels are increased in naive and CD4 +T cells from RA patients compared to healthy controls. Using next generation RNA-sequencing, transcription factor gene regulatory network (TF-GRN) and methylation analyses, we identified MYC as key regulator of autophagic memory in a human T cell line. Transcriptome and network analysis of RNA-seq data from patients' CPLs confirmed MYC as key modulator of autophagy. Importantly, inhibitor of MYC increases autophagy <h3>Conclusions</h3> The present study suggests that autophagic memory is retained both at the transcriptional and epigenetic levels as an integral part of mechanisms of efficient activation and survival of memory T cells. This mechanism is particularly relevant for cells subsets, such as CPLs, which are relevant to the immunopathogenesis of autoimmune diseases, such as arthritis. These studies have a direct translational valency as they identify autophagy and its metabolic controllers as a novel therapeutic target. <h3>Disclosure of Interest</h3> None declared
The TNFRSF members CD27 and OX40 coordinately limit T <sub>H</sub> 17 differentiation in regulatory T cells
Authors: Kelly A. Remedios, Bahar Zirak, Priscila Munoz Sandoval, Margaret M. Lowe, Devi Boda, Evan Henley, Shrishti Bhattrai, Tiffany C. Scharschmidt, Wilson Liao, Haley B. Naik, Michael D. Rosenblum
Journal: Science Immunology (2018)

Regulatory T cells (Tregs) are closely related to TH17 cells and use aspects of the TH17-differentiation program for optimal immune regulation. In several chronic inflammatory human diseases, Tregs express IL-17A, suggesting that dysregulation of TH17-associated pathways in Tregs may result in either loss of suppressive function and/or conversion into pathogenic cells. The pathways that regulate the TH17 program in Tregs are poorly understood. We have identified two TNF receptor superfamily (TNFRSF) members, CD27 and OX40, that are preferentially expressed by skin-resident Tregs Both CD27 and OX40 signaling suppressed the expression of TH17-associated genes from Tregs in a cell-intrinsic manner in vitro and in vivo. However, only OX40 played a nonredundant role in promoting Treg accumulation. Tregs that lacked both CD27 and OX40 were defective in controlling skin inflammation and expressed high levels of IL-17A, as well as the master TH17 transcription factor, RORγt. Last, we found that CD27 expression was inversely correlated with Treg IL-17 production in skin of patients with psoriasis and hidradenitis suppurativa. Together, our results suggest that TNFRSF members play both redundant and distinct roles in regulating Treg plasticity in tissues.
THU0163 Extra-articular manifestations in rheumatoid arthritis: a comprehensive analysis in a large cohort
Authors: K.R. Bonfiglioli, H. Carriço, L. Mota, A.B. Vargas-Santos, C. Albuquerque, R. Giorgi, S. Radominski, I. Pereira, M.F. Guimarães, M. Bertolo, P. Louzada, M.F. Cunha, C. Brenol, G. Castelar-Pinheiro
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Although Rheumatoid Arthirtis (RA) extra-articular manifestations (ExRA) occurrence have been decreasing over time, they are still a major mortality risk factor for patients, and also a challenge for rheumatologists. <h3>Objectives</h3> To determine the prevalence of ExRA in a large cohort, and its association with several clinical data. <h3>Methods</h3> A cross-sectional and observational study, based on a multi-centric database from a prospective cohort (The REAL – RA in real life in Brazil), in which 11 public rheumatology centres enrolled <sup>RA patients (1987</sup><sup>ARA or 2010</sup> ACR-EULAR). Data collection began in 08–2015, using a single online electronic medical record, and included demographic, socioeconomic, clinical and therapeutic characteristics. <h3>Results</h3> 1116 patients from 11 centres were included: 89% women, age [mean ±SD] 58.2±11.5 year, disease duration 14.5±12.2 year, positive Rheumatoid Factor (RF) in 77%. Regarding ExRA, 334 occurrences (detailed in table 1) were registered in 261 patients, summing for an overall prevalence of 23,4% in our cohort. Comparison among ExRA and No-ExRA groups reveals significant higher age, disease duration, Cinical Disease Activity index (CDAI), Health Assessment Questionnaire (HAQ) and Disease Activity Index (DAS 28) in ExRA group <b>(table 2)</b>. Unexpectedly, some well–known factors associated with ExRA, such as Rheumatoid factor (RF) and tobacco use, were similar among the two groups. <h3>Conclusions</h3> ExRA still shows an expressive occurrence that should not be underestimated. Our findings reinforce that long-term disease, associated with significant disability and persistent inflammatory activity, are the key factors related to ExRA development. Early aggressive treatment with effective therapies should lower the risk and severity of ExRA. <h3>Disclosure of Interest</h3> None declared
Abstract 15891: Association of Left Ventricular Dyssynchrony With Left Atrial Phasic Function: The Multi-Ethnic Study of Atherosclerosis (MESA)
Authors: Henrique Doria de Vasconcellos, Ravi D Sharma, Mohammad R Ostovaneh, Bharath Ambale-Venkatesh, Masamichi Imai, Boaz Rosen, Antoinette S Gomes, Susan Heckbert, Colin Wu, W. Gregory Hundley, David A Bluemke, Joao A Lima
Journal: Circulation (2017)

Introduction: Left ventricular (LV) dyssynchrony is a marker of LV systolic and diastolic dysfunction. Left atrial (LA) function is associated with cardiovascular (CV) diseases including heart fail...
Electrocardiography Screening for Atrial Fibrillation
Authors: Johan Engdahl, Emma Svennberg, Mårten Rosenqvist
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Polatuzumab Vedotin (Pola) Plus Bendamustine (B) with Rituximab (R) or Obinutuzumab (G) in Relapsed/Refractory (R/R) Diffuse Large B-Cell Lymphoma (DLBCL): Updated Results of a Phase (Ph) Ib/II Study
Authors: Laurie H Sehn, Alex F. Herrera, Matthew J Matasar, Manali Kamdar, Sarit Assouline, Mark Hertzberg, Tae Min Kim, Won-Seog Kim, Andrew McMillan, Muhit Özcan, Jamie M Hirata, Elicia Penuel, Ji Cheng, Grace Ku, Christopher R Flowers
Journal: Blood (2018)
Emerging evidence linking the gut microbiome to neurologic disorders
Authors: Jessica A. Griffiths, Sarkis K. Mazmanian
Journal: Genome Medicine (2018)

The gut microbiome contributes to the development and function of the immune, metabolic, and nervous systems. Furthermore, commensal bacteria modulate symptoms and pathology in mouse models of neuropsychiatric and neurodevelopmental diseases. Uncovering mechanisms that are utilized by the microbiome to mediate gut–brain connections may provide novel opportunities to target therapies to the gut in order to treat neurologic disorders.
Molecular Classification of Lymph Node Metastases Subtypes Predict for Survival in Head and Neck Cancer
Authors: Lei Huang, Odile David, Robert J. Cabay, Klara Valyi-Nagy, Virgilia Macias, Rong Zhong, Barry Wenig, Lawrence Feldman, Ralph Weichselbaum, Michael T. Spiotto
Journal: Clinical Cancer Research (2018)

In advanced stage head and neck squamous cell cancers (HNSCC), approximately half of the patients with lymph node metastases (LNM) are not cured. Given the heterogeneous outcomes in these patients, we profiled the expression patterns of LNMs to identify the biological factors associated with patient outcomes.Experimental Design: We performed mRNAseq and miRNAseq on 72 LNMs and 29 matched primary tumors from 34 patients with HNSCC. Clustering identified molecular subtypes in LNMs and in primary tumors. Prediction Analysis of Microarrays algorithm identified a 73-gene classifier that distinguished LNM subtypes. Gene-set enrichment analysis identified pathways upregulated in LNM subtypes.Integrative clustering identified three distinct LNM subtypes: (i) an immune subtype (Group 1), (ii) an invasive subtype (Group 2), and (iii) a metabolic/proliferative subtype (Group 3). Group 2 subtype was associated with significantly worse locoregional control and survival. LNM-specific subtypes were not observed in matched primary tumor specimens. In HNSCCs, breast cancers, and melanomas, a 73-gene classifier identified similar Group 2 LNM subtypes that were associated with worse disease control and survival only when applied to lymph node sites, but not when applied to other primary tumors or metastatic sites. Similarly, previously proposed prognostic classifiers better distinguished patients with worse outcomes when applied to the transcriptional profiles of LNMs, but not the profiles of primary tumors.The transcriptional profiles of LNMs better predict outcomes than transcriptional profiles of primary tumors. The LNMs display site-specific subtypes associated with worse disease control and survival across multiple cancer types.
Low Serum Hepcidin Is Associated With Reduced Short‐Term Survival in Adults With Acute Liver Failure
Authors: Igor Spivak, Jyoti Arora, Caitlyn Meinzer, Valerie Durkalski‐Mauldin, William M. Lee, Christian Trautwein, Robert J. Fontana, Pavel Strnad
Journal: Hepatology (2018)

The liver has an important role in iron homeostasis through the synthesis of the serum transporter transferrin and the iron hormone hepcidin. The aim of this study was to analyze parameters of iron metabolism in a multicenter cohort of adult patients with acute liver failure (ALF) and in an acetaminophen (APAP)‐induced ALF mouse model. A representative subset of 121 adults with ALF (including 66 APAP‐related patients) had baseline serum samples tested for ferritin, transferrin, iron, and hepcidin. Outcomes at 3 weeks after enrollment were categorized as spontaneous survivor (SS) versus death/transplantation (NSS). Mice were assessed before (controls) and 4 and 18 hours after injection of 300 mg/kg APAP. Patients with ALF as well as APAP‐treated mice displayed increased ferritin and diminished serum hepcidin and hepcidin/ferritin ratio. SS had lower iron (29.1% vs. 34.5 µmol/L; P < 0.05) and transferrin saturation (60.9% vs. 79.1%; P < 0.01), but higher hepcidin levels (8.2 vs. 2.7 ng/mL; P < 0.001) and hepcidin/ferritin ratio (0.0047 vs. 0.0009; P < 0.001) than NSS. In a multivariate analysis, a log‐transformed hepcidin‐containing model displayed similar prognostic power as the established Acute Liver Failure Study Group index (C‐statistic 0.87 vs. 0.85) and was better than Model for End‐Stage Liver Disease score (C‐statistic 0.76). In mice, hepcidin levels inversely correlated with the surrogate of liver injury. Conclusion: Our findings demonstrate that several serum iron parameters significantly associate with 3‐week outcomes in adults with ALF. Among them, hepcidin decreases early during experimental APAP‐induced ALF, is an independent predictor and might be a useful component of future prognostic scores.
Abstract 14561: The Role of Symptoms in Adherence to mHealth ECG Monitoring for Atrial Fibrillation
Authors: Meghan Reading, Angelo B Biviano, Lindsey Mitrani, Kathleen T Hickey
Journal: Circulation (2017)

Introduction: Mobile health (mHealth) ECG technology via a smartphone can capture a real time ECG recording and accurately document AF. However, AF is often asymptomatic or individuals may not be a...
Activation of Peroxisome Proliferator-Activated Receptors α and δ Synergizes with Inflammatory Signals to Enhance Adoptive Cell Therapy
Authors: Samuel D. Saibil, Michael St. Paul, Robert C. Laister, Carlos R. Garcia-Batres, Kavita Israni-Winger, Alisha R. Elford, Natasha Grimshaw, Céline Robert-Tissot, Dominic G. Roy, Russell G. Jones, Linh T. Nguyen, Pamela S. Ohashi
Journal: Cancer Research (2018)

Memory CD8+ T cells (Tmem) are superior mediators of adoptive cell therapy (ACT) compared with effector CD8+ T cells (Teff) due to increased persistence in vivo. Underpinning Tmem survival is a shift in cellular metabolism away from aerobic glycolysis towards fatty acid oxidation (FAO). Here we investigated the impact of the peroxisome proliferator-activated receptor (PPAR) agonist GW501516 (GW), an agent known to boost FAO in other tissues, on CD8+ T-cell metabolism, function, and efficacy in a murine ACT model. Via activation of both PPARα and PPARδ/β, GW treatment increased expression of carnitine palmitoyl transferase 1a, the rate-limiting enzyme of FAO, in activated CD8+ T cells. Using a metabolomics approach, we demonstrated that GW increased the abundance of multiple different acylcarnitines, consistent with enhanced FAO. T cells activated in the presence of GW and inflammatory signals, either mature dendritic cells or IL12, also demonstrated enhanced production of IFNγ and expression of T-bet. Despite high expression of T-bet, a characteristic of short-lived effector cells, GW-treated cells demonstrated enhanced persistence in vivo and superior efficacy in a model of ACT. Collectively, these data identify combined PPARα and PPARδ/β agonists as attractive candidates for further studies and rapid translation into clinical trials of ACT. SIGNIFICANCE: Dual activation of peroxisome proliferator-activated receptors α and δ improves the efficacy of adoptive cell therapy by reprogramming T-cell metabolism and cytokine expression.
FRI0574 Radiofrequency echographic multi spectrometry (REMS) for the non-ionising diagnosis of osteoporosis at femoral neck: results of a multicenter clinical study comparing rems and dxa
Authors: L. Cavalli, G. Arioli, G. Bianchi, C. Caffarelli, M. Matucci Cerinic, L. Cianferotti, F. Conversano, M. Di Paola, D. Gatti, G. Girasole, A. Giusti, S. Gonnelli, M. Manfredini, M. Muratore, R. Nuti, P. Pisani, E. Quarta, M. Rossini, O. Viapiana, M.L. Brandi
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Radiofrequency Echographic Multi Spectrometry (REMS) is an innovative densitometric technique able to automatically provide BMD values, which it has been shown to highly correlate with BMD obtained by DXA.<sup>1</sup> <h3>Objectives</h3> To evaluate the accuracy of REMS measurements in postmenopausal women's femoral neck health assessment versus DXA results in a multicenter clinical study. <h3>Methods</h3> In seven Italian referral centres for osteoporosis management, 1659 postmenopausal women (51–70 years old) were enrolled. Both DXA and REMS examinations were performed on each patient at femoral neck, in the strictest adherence to the corresponding guidelines. After excluding the scans affecting by errors, the REMS diagnostic accuracy was evaluated by assessing sensibility and specificity in the discrimination between "osteoporotic" and "healthy" patients; the degree of correlation between DXA-BMD and REMS-BMD was quantified through Pearson's correlation coefficient (r) evaluation. In addition, the agreement between DXA-BMD and REMS-BMD was measured calculating the root mean square error (<i>RMSE</i>). <h3>Results</h3> A strong correlation (r=0.94, p&lt;0.001) was detected between BMD obtained by DXA and REMS – estimated BMD at femoral neck, with a low residual error (<i>RMSE</i>=0.034 g/cm<sup>2</sup>). In addition to this, REMS resulted to have a high capability to discriminate osteoporotic from healthy patients (sensibility=94.4%, specificity=95.6%). <h3>Conclusions</h3> Thanks to its high capability to identify osteoporotic patients, and the strong correlation with DXA parameters, REMS has been shown to be an accurate non-ionising approach to detect osteoporosis at femoral neck. <h3>Reference</h3> [1] Casciaro S, et al. UMB2016;42:1337–56. <h3>Disclosure of Interest</h3> None declared
Abstract 15943: Left Ventricular Regional Longitudinal Displacement Assessed by Tissue Doppler Imaging is a Powerful Predictor of All-cause Mortality in Patients With Systolic Heart Failure
Authors: Morten Sengeløv, Peter Godsk Jørgensen, Niels Eske Bruun, Flemming Javier Olsen, Thomas Fritz Hansen, Jan Skov Jensen, Tor Biering-Sørensen
Journal: Circulation (2015)

Objective: Tissue tracking (TT), obtained by tissue Doppler imaging (TDI), can be utilized to assess the mitral annular longitudinal displacement (LD) during systole. However, the prognostic utility of regional LD in patients with heart failure with reduced ejection fraction (HFrEF) is unknown. Methods: Transthoracic echocardiographic examinations from 911 patients with HFrEF were retrieved from a heart failure clinic’s database. The exams were performed from 2005 to 2013. The echocardiographic images were subsequently analyzed obtaining conventional echocardiographic measurements. Regional LD was obtained from the three apical TDI projections with sampling at six mitral annular sites located at the anterior, lateral, posterior, inferior, septal and anteroseptal myocardial walls. Results: During a median follow-up period of 40 months 150 (16.4 %) patients died. Patients that died had significantly lower LVEF (23.3% vs 28.3%, p&lt;0.001) and lower regional LD in all six mitral annular sites (Figure). Many conventional echocardiographic parameters presented as predictors of mortality (LVEF, LVMI, LAVI, E, E/e’, deceleration time and TAPSE). However, only LD at the septal and inferior annular sites remained independent predictors of mortality in cox proportional-hazards models after adjusting for age, gender, BMI, total cholesterol, heart rate, atrial fibrillation, non-independent diabetes mellitus and the aforementioned conventional echocardiographic predictors (Figure). In addition, the septal and the inferior sites had the highest Harrell’s C-statistic of all the echocardiographic predictors (0.70 and 72, respectively). Conclusion: In patients with severe heart failure, septal and inferior LD are independent predictors of all-cause mortality. Furthermore, septal and inferior LD proved to be superior prognosticators when compared to all the conventional echocardiographic parameters.