tbuckley/cabot-search huggingface dataset:
Abstract 16352: Patterns of Sedentary Behavior on Exercise and Non-Exercise Days Among Older Adults Referred for Supervised Exercise Therapy for Peripheral Artery Disease
Authors: Mary O Whipple, Erica Schorr, Diane Treat-Jacobson
Journal: Circulation (2018)

Introduction: There is a growing body of evidence supporting the unique effects of both total volume and patterns of sedentary behavior on health outcomes, however these patterns have not been adeq...
Novel use of a cardiac septal occluder to treat a chronic recalcitrant bariatric fistula after Roux-en-Y gastric bypass
Authors: Diogo Turiani Hourneaux de Moura, Igor Braga Ribeiro, Mateus Pereira Funari, Alberto Baptista, Christopher C. Thompson, Eduardo Guimarães Hourneaux de Moura
Journal: Endoscopy (2019)

Although considered the gold standard for the treatment of obesity, bariatric surgeries are not free of complications. Fistulas occur after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy in up to 8.3 % and 7 % of patients, respectively [1] [2]. We describe the first report of the off-label use of the cardiac septal occluder (AMPLATZER Septal Occluder; Abbott, St. Paul, Minnesota, USA) for the treatment of a chronic bariatric fistula ([Video 1]).
Sudden sensorineural hearing loss in adults
Authors: Abdel-Majeed Zedan
Journal: BMJ (2019)

Fishman and Cullen discuss the management of sudden hearing loss in adults.1 Delay in tackling sudden sensorineural, rather than conductive, hearing loss may have medicolegal implications because early intervention is generally considered to be the only chance for possible improvement in hearing loss of undetermined cause. Although no evidence exists that …
Prenatal Developmental Origins of Future Psychopathology: Mechanisms and Pathways
Authors: Catherine Monk, Claudia Lugo-Candelas, Caroline Trumpff
Journal: Annual Review of Clinical Psychology (2019)

The developmental origins of health and disease hypothesis applied to neurodevelopmental outcomes asserts that the fetal origins of future development are relevant to mental health. There is a third pathway for the familial inheritance of risk for psychiatric illness beyond shared genes and the quality of parental care: the impact of pregnant women's distress-defined broadly to include perceived stress, life events, depression, and anxiety-on fetal and infant brain-behavior development. We discuss epidemiological and observational clinical data demonstrating that maternal distress is associated with children's increased risk for psychopathology: For example, high maternal anxiety is associated with a twofold increase in the risk of probable mental disorder in children. We review several biological systems hypothesized to be mechanisms by which maternal distress affects fetal and child brain and behavior development, as well as the clinical implications of studies of the developmental origins of health and disease that focus on maternal distress. Development and parenting begin before birth.
Application of a sequential multiple assignment randomized trial (SMART) design in older patients with chronic lymphocytic leukemia
Authors: A.S. Ruppert, J. Yin, M. Davidian, A.A. Tsiatis, J.C. Byrd, J.A. Woyach, S.J. Mandrekar
Journal: Annals of Oncology (2019)

Ibrutinib therapy is safe and effective in patients with chronic lymphocytic leukemia (CLL). Currently, ibrutinib is administered continuously until disease progression. Combination regimens with ibrutinib are being developed to deepen response which could allow for ibrutinib maintenance (IM) discontinuation. Among untreated older patients with CLL, clinical investigators had the following questions: (i) does ibrutinib + venetoclax + obinutuzumab (IVO) with IM have superior progression-free survival (PFS) compared with ibrutinib + obinutuzumab (IO) with IM, and (ii) does the treatment strategy of IVO + IM for patients without minimal residual disease complete response (MRD- CR) or IVO + IM discontinuation for patients with MRD- CR have superior PFS compared with IO + IM.
Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity
Authors: Lawrence Kazak, Janane F. Rahbani, Bozena Samborska, Gina Z. Lu, Mark P. Jedrychowski, Mathieu Lajoie, Song Zhang, LeeAnn Ramsay, Florence Y. Dou, Danielle Tenen, Edward T. Chouchani, Petras Dzeja, Ian R. Watson, Linus Tsai, Evan D. Rosen, Bruce M. Spiegelman
Journal: Nature Metabolism (2019)
Best Practices for Pain Management
Authors: Rita Rubin
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 17668: Comparative Efficacy of Nebivolol and Metoprolol to Prevent Tachycardia-Induced Cardiomyopathy in a Porcine Model
Authors: Alireza Nazeri, MacArthur A Elayda, Ana Maria Segura, Raymond F Stainback, Vei-Vei Lee, Christina Bove, Luiz Sampaio, Brian Grace, Alex Zade, Ali Massumi, Mehdi Razavi
Journal: Circulation (2013)

Introduction: Chronic tachycardia is a well-known cause of non-ischemic cardiomyopathy. We hypothesized that nebivolol, a beta-blocker with nitric oxide activity, would be superior to a pure beta-b...
Overlapping Surgery and Perioperative Outcomes
Authors: Edward H. Livingston
Journal: JAMA (2019)

Eric Sun, MD, PhD; Michelle M. Mello, JD, PhD; Chris A. Rishel, MD, PhD; Michelle T. Vaughn, MPH; Sachin Kheterpal, MD, MBA; Leif Saager, Dr Med, MMM; Lee A. Fleisher, MD; Edward J. Damrose, MD; Bassam Kadry, MD; Anupam B. Jena, MD, PhD; for the Multicenter Perioperative Outcomes Group (MPOG)
Efficacy of Maintenance Therapy Following Auto-HSCT Depending on MRD Status in Patients with Multiple Myeloma
Authors: Maxim V. Solovev, Larisa P. Mendeleeva, Maiia V. Firsova, Irina V. Galtseva, Julia Davydova, Eduard G. Gemdzhian, Valery G. Savchenko
Journal: Blood (2018)
Abstract 3347: Characterization of an epithelial micro-pattern within ducts and lobules of the human breast: The topography of estrogen receptor expression
Authors: Rene Villadsen, Agla Fridriksdottir, Jiyoung Kim, Lone Ronnov-Jessen, Ole W. Petersen
Journal: Cancer Research (2011)

Abstract The human breast is a unique organ in that it undergoes most of its development after birth under the control of systemic hormones. The adult human breast undergoes cycles of cell proliferation and apoptosis not only during pregnancy but also within the menstrual cycle throughout the reproductive life of women. These highly dynamic changes are thought to rely on the presence of a mammary stem cell population. Recently, we have succeeded in defining a stem cell hierarcy as well as a stem cell zone located to ducts in the normal human mammary gland. In the present study we have utilized multiparameter cell sortings to isolate two types of progenitors present in the luminal compartment of the mammary gland. One population defines a lineage-restricted progenitor with the capacity of expressing endocrine receptors. The other compartment is enriched for cells with stem cell activity, including the ability to form TDLU-like structures in Matrigel. Further characterization of these populations include testing of expression markers for stem cell activity, lineage-differentiation, anti-apoptotic pathways, as well as finding optimal culture conditions for propagating the cells in vitro. This may lead to identification of those long-term breast resident(s) that accumulate enough genetic hits for clonal expansion and tumor development, i.e. the cellular origin(s) of breast cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3347. doi:10.1158/1538-7445.AM2011-3347
Clinical Features and Comorbidities of Patients With Necrobiosis Lipoidica With or Without Diabetes
Authors: David A. Hashemi, Zoe O. Brown-Joel, Elizabeth Tkachenko, Caroline A. Nelson, Megan H. Noe, Sotonye Imadojemu, Ruth Ann Vleugels, Arash Mostaghimi, Karolyn A. Wanat, Misha Rosenbach
Journal: JAMA Dermatology (2019)

<h3>Importance</h3> Necrobiosis lipoidica (NL) is a rare granulomatous condition. Current knowledge of its key features is based on a limited number of studies and case reports, leading to wide variability in the characterization of its defining features, with limited comparison of patients with or without diabetes. <h3>Objective</h3> To evaluate the epidemiologic characteristics, clinical features, and disease associations of NL in patients with or without type 1 or 2 diabetes. <h3>Design, Setting, and Participants</h3> This multicenter retrospective review included 236 patients aged 15 to 84 years who were evaluated and received a diagnosis of NL at the University of Pennsylvania Health System between January 1, 2008, and July 15, 2018; University of Iowa Hospitals and Clinics between January 1, 2000, and June 15, 2018; and Brigham and Women's Hospital and Massachusetts General Hospital between January 1, 2000, and February 15, 2018. <h3>Main Outcomes and Measures</h3> Patient demographics, clinical features, medical comorbidities, and biopsy status. <h3>Results</h3> Of the 236 patients with NL, 200 were women and 36 were men, and 182 were white, with a median age at presentation of 50.0 years (interquartile range, 33.0-59.0 years). The diagnosis was biopsy proven in 156 patients (66.1%). Of the 230 patients with location specified, 225 (97.8%) had NL on the lower legs. A total of 138 patients with NL (58.5%; 95% CI, 52.7%-65.3%) had diabetes. The median hemoglobin A<sub>1c</sub>for patients with diabetes was 8.00% (interquartile range, 6.68%-9.50%) (to convert hemoglobin A<sub>1c</sub>to proportion of total hemoglobin, multiply by 0.01). Patients with diabetes were significantly younger than patients without diabetes (median age, 45.0 vs 52.0 years;<i>P</i> = .005), and slightly less likely to be female (112 of 138 [81.2%] vs 87 of 96 [90.6%];<i>P</i> = .046), but lesion characteristics were otherwise comparable. Other notable comorbidities included obesity in 95 of 184 patients (51.6%; 95% CI, 44.4%-58.9%), hypertension in 104 of 230 patients (45.2%), dyslipidemia in 98 of 225 patients (43.6%), and thyroid disease in 56 of 229 patients (24.5%). <h3>Conclusions and Relevance</h3> This study of NL supports its associations with diabetes as well as obesity, hypertension, dyslipidemia, and thyroid disease. Younger age and female sex were observed more frequently in patients with diabetes. Otherwise, NL lesions in patients with or without diabetes shared many clinical features, suggesting that risk factors outside of elevated blood glucose may play an important role in the disease. Future studies should evaluate these associations with the goal of further elucidating NL's underlying pathophysiologic characteristics.
The Inflammatory Bowel Disease Yearbook 2003.
Authors: D van Heel
Journal: Gut (2004)

Edited by C Bernstein. London: Remedica Publishing Ltd, 2003, £60.00, pp 179. ISBN ISBN 1-901346-57-9

This is the first in a planned yearly series of updates on the latest topics in inflammatory bowel disease clinical practice and research. I was initially sceptical that the hard backed book format could provide a reasonably current overview but was pleasantly …
Timing of Renal Replacement Therapy for Severe Acute Kidney Injury in Critically Ill Patients
Authors: Stéphane Gaudry, Jean-Pierre Quenot, Alexandre Hertig, Saber Davide Barbar, David Hajage, Jean-Damien Ricard, Didier Dreyfuss
Journal: American Journal of Respiratory and Critical Care Medicine (2019)

Acute kidney injury (AKI) affects many ICU patients and is responsible for increased morbidity and mortality. Although lifesaving in many situations, renal replacement therapy (RRT) may be associated with complications, and the appropriate timing of its initiation is still the subject of intense debate. An early initiation strategy can prevent some metabolic complications, whereas a delayed one may allow for renal function recovery in some patients without need for this costly and potentially dangerous technique. For years, most of the knowledge on this issue stemmed from observational studies or small randomized controlled trials. Recent randomized controlled trials have indicated that a watchful waiting strategy (in the absence of life-threatening conditions such as severe hyperkalemia or pulmonary edema) during severe AKI allowed many patients to escape RRT and did not seem to adversely affect survival compared with a strategy of immediate RRT. In addition, data suggest that a delayed strategy may reduce the rate of complications (such as catheter infection) and favor renal function recovery. Ongoing studies will have to both confirm these conclusions and clarify to what extent the delay in initiating RRT can be prolonged. Pending those results, the bulk of evidence suggests that, in the absence of potential severe complications of AKI, delaying RRT is a valid and safe strategy that may also allow for considerable cost savings.
Advances in ultrasound diagnosis in chronic liver diseases
Authors: Hitoshi Maruyama, Naoya Kato
Journal: Clinical and Molecular Hepatology (2019)

Chronic liver disease is a major disorder worldwide. A better understanding of anatomy, blood flow, and pathophysiology may be a key issue for their proper management. Ultrasound (US) is a simple and non-invasive diagnostic tool in the abdominal field. Doppler mode offers real-time hemodynamic evaluation, and the contrast-enhanced US is one of the most frequently used modalities for the detailed assessment. Further development in digital technology enables threedimensional (3D) visualization of target images with high resolution. This article reviews the wide ranges of application in the abdominal US and describes the recent progress in the diagnosis of chronic liver diseases.
Impact of Intended and Relative Dose Intensity of RCHOP in a Large, Consecutive Cohort of Elderly DLBCL Patients: No Difference in DFS for 70-80 Years Versus &gt;80 Years and Idi Independently Predicts Survival
Authors: Toby A. Eyre, Nicolas Martinez-Calle, Catherine Hildyard, David W. Eyre, Hannah Plaschkes, Jonathan Griffith, Julia Wolf, Chris P Fox, Andrew McMillan, Mark Bishton, Graham P. Collins, Chris Hatton
Journal: Blood (2018)
Adverse Drug Reactions to Guideline-Recommended Heart Failure Drugs in Women
Authors: Sophie H. Bots, Floor Groepenhoff, Anouk L.M. Eikendal, Cara Tannenbaum, Paula A. Rochon, Vera Regitz-Zagrosek, Virginia M. Miller, Danielle Day, Folkert W. Asselbergs, Hester M. den Ruijter
Journal: JACC Heart Failure (2019)

This study sought to summarize all available evidence on sex differences in adverse drug reactions (ADRs) to heart failure (HF) medication. Women are more likely to experience ADRs than men, and these reactions may negatively affect women’s immediate and long-term health. HF in particular is associated with increased ADR risk because of the high number of comorbidities and older age. However, little is known about ADRs in women with HF who are treated with guideline-recommended drugs. A systematic search of PubMed and EMBASE was performed to collect all available information on ADRs to angiotensin-converting enzyme inhibitors, β-blockers, angiotensin II receptor blockers, mineralocorticoid receptor antagonists, ivabradine, and digoxin in both women and men with HF. The search identified 155 eligible records, of which only 11 (7%) reported ADR data for women and men separately. Sex-stratified reporting of ADRs did not increase over the last decades. Six of the 11 studies did not report sex differences. Three studies reported a higher risk of angiotensin-converting enzyme inhibitor–related ADRs in women, 1 study showed higher digoxin-related mortality risk for women, and 1 study reported a higher risk of mineralocorticoid receptor antagonist–related ADRs in men. No sex differences in ADRs were reported for angiotensin II receptor blockers and β-blockers. Sex-stratified data were not available for ivabradine. These results underline the scarcity of ADR data stratified by sex. The study investigators call for a change in standard scientific practice toward reporting of ADR data for women and men separately.
Introduction: Reviews in Environmental Health, 1997
Authors: Thomas J. Goehl
Journal: Environmental Health Perspectives (1997)

supplement containing review papers that cover the broad field of environmental health.The objectives of the supplement are to summarize new developments in environmentally relevant areas, to provide a perspective for these new findings, and to provide sufficient background information for those not familiar with the specific topic.While it is imperative to have specialists in the various disciplines, it is critical that scientists not lose sight of the broader picture.In this annual review issue we continue to provide informa- tion that encourages our readers to reach beyond their own scientific
Therapeutic Targeting of the Ubiquitin Conjugating Enzyme UBE2N in Myeloid Malignancies
Authors: Laura Barreyro, Avery Sampson, Kathleen Hueneman, Lyndsey C Bolanos, Mario Pujato, Somchai Chutipongtanate, Michael Wyder, Wendy Haffey, Kwangmin Choi, Yaseswini Neelamraju, Molly A Smith, Madeline Niederkorn, Vighnesh Ramesh, Tomoya Muto, Eric O'Brien, Cem Meydan, Susanne Christie, Xiaona Liu, Francine Garret-Bakelman, Boris Bartholdy, Britta Will, Matthew T. Weirauch, Zartash Gul, Stephen Medlin, John Peter Perentesis, Kenneth D Greis, William Seibel, Daniel T. Starczynowski
Journal: Blood (2018)
Prenatal vitamins in early pregnancy may lower risk of autism in high risk families
Authors: Susan Mayor
Journal: BMJ (2019)

Mothers of children with autism spectrum disorder (ASD) who take prenatal vitamins in the first month of pregnancy have a lower risk of having another child with the condition than high risk women not taking the vitamins, a small prospective cohort study has reported.1

“This study is the first to our knowledge to suggest that maternal prenatal vitamin intake during the first month of pregnancy may reduce ASD recurrence by half in younger siblings of children with ASD in high risk families,” said the researchers, led by Rebecca Schmidt of the University of California, USA.

But they warned that further research is needed …
Genetic Analysis of B-Cell Acute Lymphoblastic Leukemia Dissemination to the Central Nervous System Identifies Clonal Selection and Therapeutic Vulnerability
Authors: Robert Vanner, Stephanie M. Dobson, Ildiko Grandal, Olga I. Gan, Jessica McLeod, James Kennedy, Veronique Voisin, Cynthia Guidos, Jayne S. Danska, Esme Waanders, Mark D. Minden, Charles G. Mullighan, John E. Dick
Journal: Blood (2018)
Abstract A45: Targeting eIF4A dependent translation as therapeutics in pancreatic cancer
Authors: Kamini Singh, Nicolas Lecomte, Stefan Stark, Antonija Burčul, Grbovic-Huezo Olivera, Adrien Grimont, Agnes Viale, Prathibha Mohan, Man Jiang, Elisa Destanchia, Askan Gokce, Gunnar Rätsch, Steve D. Leach, Hans-Guido Wendel
Journal: Cancer Research (2017)

Abstract RNA translation is activated in aggressive pancreatic cancer and at the same time is also refractory to mTOR inhibition. We have used a translation inhibitor for eIF4A, RNA helicase that is downstream of mTOR signaling and can be functionally targeted in pancreatic cancer. We establish that Silvestrol and its analog CR-31B showed potent anti-tumor activity in pancreatic cancer cell lines in vitro and in vivo. Silvestrol/CR-31B reduced pancreatic cancer cells and organoids growth derived from mouse model of pancreatic cancer and human patient samples in vitro. Further we identify the genome wide translational targets of Silvestrol in pancreatic cancer cell line that lacks response to mTOR signaling through loss of EIF4EBP1. Silvestrol down regulate translation of many key oncogenes and others cellular factors involved in oncogenic signaling specific to pancreatic cancer. Silvestrol targets were also enriched for G-quadruplex structure in their 5' UTR. With this study we establish a new mechanism of targeting pancreatic cancer cells through translation inhibition and identify newer proteins as therapeutic targets that are regulated independent of mTOR signaling. Citation Format: Kamini Singh, Nicolas Lecomte, Stefan Stark, Antonija Burčul, Grbovic-Huezo Olivera, Adrien Grimont, Agnes Viale, Prathibha Mohan, Man Jiang, Elisa Destanchia, Askan Gokce, Gunnar Rätsch, Steve D. Leach, Hans-Guido Wendel. Targeting eIF4A dependent translation as therapeutics in pancreatic cancer. [abstract]. In: Proceedings of the AACR Special Conference on Translational Control of Cancer: A New Frontier in Cancer Biology and Therapy; 2016 Oct 27-30; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2017;77(6 Suppl):Abstract nr A45.