tbuckley/cabot-search huggingface dataset:
THU0213 Adherence and persistence to disease modifying anti rheumatic drugs in colombian patients with rheumatoid arthritis
Authors: N. Pertuz-Charris, F.L. Ochoa-Jaramillo, D. Gil-Calderón, M.A. Alzate-Vinasco, V. Vélez-Marín, D. Hernández-Parra, R. Pineda-Tamayo
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Adherence in the treatment of rheumatoid arthritis (RA) ranges 20% to 70% in worldwide population.<sup>1</sup> In Colombia there are no studies comparing adherence and persistence to conventional and biological treatment. <h3>Objectives</h3> To determine adherence and persistence and associated factors to the treatment of conventional disease-modifying anti-rheumatic drugs (cDMARD) and biological DMARD (bDMARD) in patients with RA under real world data. <h3>Methods</h3> We conducted an observational, analytical retrospective cohort study from January 2015 to December 2016. The study population was 552 RA patients older than 18 years who received any cDMARD treatment in monotherapy or combined with two or more cDMARD and bDMARD (Rituximab and Tofacitinib were excluded). Clinical information was obtained from electronic clinical records and Morisky-Green test was performed during the follow-up. Univariate analysis (proportions and medians), bivariate analysis [relative risk (RR)] and multivariate analysis (logistic regression and Kaplan-Meier survival curve) were developed. <h3>Results</h3> Eighty nine percent were women, the median age was 59 years, 50% have ≥12 years of duration of disease. Adherence for cDMARD was 61% and for bDMARD 56%. There was an association between adherence and high degree education level (adjusted RR=2.1; <b>CI: 1.09–4.14</b>) and non-adherence with clinical factors such as high disease activity (adjusted RR=0.41; <b>CI: 0.22–0.75</b>); in the cDMARD group the greatest persistence was leflunomide (mean: 631 days) followed by methotrexate (mean: 526 days) and in the bDMARD group was etanercept (mean 1577 days) and tocilizumab (mean 1064 days). Patients with social support had greater persistence in the treatment with cDMARD (adjusted HR=2.1; <b>CI: 1.11–4.28</b>). <h3>Conclusions</h3> In real world data, education level and disease activity significantly impact adherence level in RA patients. Social support positively impacts the persistence of the treatment of RA patients, which suggest the implementation of care programs taking this aspect into consideration in order to improve outcomes. <h3>Reference</h3> [1] De Klerk E, van der Heijde D, Landewé R, van der Tempel H, Urquhart J, van der Linden S. Patient compliance in rheumatoid arthritis, polymyalgia rheumatica, and gout. J Rheumatol2003;(1):44–54. <h3>Disclosure of Interest</h3> None declared
Rostral and Caudal Ventral Tegmental Area GABAergic Inputs to Different Dorsal Raphe Neurons Participate in Opioid Dependence
Authors: Yue Li, Chun-Yue Li, Wang Xi, Sen Jin, Zuo-Hang Wu, Ping Jiang, Ping Dong, Xiao-Bin He, Fu-Qiang Xu, Shumin Duan, Yu-Dong Zhou, Xiao-Ming Li
Journal: Neuron (2019)
Allogeneic Hematopoietic Stem Cell Transplantation in Older Patients with Acute Myeloid Leukemia: Analysis of the Francophone Society for Stem Cell Transplantation and Cell Therapy
Authors: Regis Peffault De Latour, Matthieu Resche-Rigon, Didier Blaise, Johan Maertens, Patrice Ceballos, Patrice Chevallier, Edouard Forcade, Anne Huynh, Pierre Simon Rohrlich, Helene Labussiere-Wallet, Jacques-Olivier Bay, Yves Chalandon, Gerard Socie, Marie Thérèse Rubio
Journal: Blood (2018)
Adiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium
Authors: Alex R Chang, Morgan E Grams, Shoshana H Ballew, Henk Bilo, Adolfo Correa, Marie Evans, Orlando M Gutierrez, Farhad Hosseinpanah, Kunitoshi Iseki, Timothy Kenealy, Barbara Klein, Florian Kronenberg, Brian J Lee, Yuanying Li, Katsuyuki Miura, Sankar D Navaneethan, Paul J Roderick, Jose M Valdivielso, Frank L J Visseren, Luxia Zhang, Ron T Gansevoort, Stein I Hallan, Andrew S Levey, Kunihiro Matsushita, Varda Shalev, Mark Woodward
Journal: BMJ (2019)

Abstract Objective To evaluate the associations between adiposity measures (body mass index, waist circumference, and waist-to-height ratio) with decline in glomerular filtration rate (GFR) and with all cause mortality. Design Individual participant data meta-analysis. Setting Cohorts from 40 countries with data collected between 1970 and 2017. Participants Adults in 39 general population cohorts (n=5 459 014), of which 21 (n=594 496) had data on waist circumference; six cohorts with high cardiovascular risk (n=84 417); and 18 cohorts with chronic kidney disease (n=91 607). Main outcome measures GFR decline (estimated GFR decline ≥40%, initiation of kidney replacement therapy or estimated GFR &lt;10 mL/min/1.73 m 2 ) and all cause mortality. Results Over a mean follow-up of eight years, 246 607 (5.6%) individuals in the general population cohorts had GFR decline (18 118 (0.4%) end stage kidney disease events) and 782 329 (14.7%) died. Adjusting for age, sex, race, and current smoking, the hazard ratios for GFR decline comparing body mass indices 30, 35, and 40 with body mass index 25 were 1.18 (95% confidence interval 1.09 to 1.27), 1.69 (1.51 to 1.89), and 2.02 (1.80 to 2.27), respectively. Results were similar in all subgroups of estimated GFR. Associations weakened after adjustment for additional comorbidities, with respective hazard ratios of 1.03 (0.95 to 1.11), 1.28 (1.14 to 1.44), and 1.46 (1.28 to 1.67). The association between body mass index and death was J shaped, with the lowest risk at body mass index of 25. In the cohorts with high cardiovascular risk and chronic kidney disease (mean follow-up of six and four years, respectively), risk associations between higher body mass index and GFR decline were weaker than in the general population, and the association between body mass index and death was also J shaped, with the lowest risk between body mass index 25 and 30. In all cohort types, associations between higher waist circumference and higher waist-to-height ratio with GFR decline were similar to that of body mass index; however, increased risk of death was not associated with lower waist circumference or waist-to-height ratio, as was seen with body mass index. Conclusions Elevated body mass index, waist circumference, and waist-to-height ratio are independent risk factors for GFR decline and death in individuals who have normal or reduced levels of estimated GFR.
Abstract P097: Trajectories of Childhood Blood Pressure and Adult Left Ventricular Hypertrophy: The Bogalusa Heart Study
Authors: Tao Zhang, Shengxu Li, Lydia Bazzano, Jiang He, Paul Whelton, Wei Chen
Journal: Circulation (2018)

Background: Childhood blood pressure (BP) levels predict adult left ventricular hypertrophy (LVH). However, information is limited on the association between childhood BP trajectory and adult LVH. This longitudinal study aims to characterize longitudinal BP trajectories from childhood and examine the impact of level-independent childhood BP trajectories on adult LVH and remodeling patterns. Methods: The longitudinal cohort consisted of 1,154 adults (787 whites and 367 blacks) who had repeated measurements of BP 4-15 times from childhood (4-19 years) to adulthood (20-51 years) and assessment of echocardiographic LV dimensions in adulthood. Model-estimated levels and linear slopes of BP at childhood age points were calculated in one-year intervals using the growth curve parameters and their first derivatives, respectively. Results: Linear and nonlinear curve parameters differed significantly between race-sex groups. BP showed race and sex differences from age 15 years onwards. Adults with LVH had higher long-term BP levels than normal adults in race-sex groups. Linear and nonlinear slope parameters of BP differed consistently, significantly between LVH and normal groups. Level-independent linear slopes of systolic BP showed significantly negative associations (odds ratio=0.75~0.82, p=0.001~0.015) during pre-puberty period of 4-9 years but significantly positive associations (odd ratio=1.29~1.46, p=0.001~0.008) during the puberty period of 13-19 years with adult LVH, adjusting for covariates (see the figure below). These associations were consistent across race-sex groups. Of note, the association of childhood BP linear slopes with concentric LVH was significantly stronger than that with eccentric LVH during the puberty period of 12-19 years. Conclusions: These observations indicate that the impact of BP trajectories on adult LVH and geometric patterns originates in childhood. Puberty is a crucial period for the development of LVH in later life, which has implications for early prevention.
AB0544 Role of anti-neuronal antibodies (A-NA) in epilepsy lupus patients
Authors: C. Mazzuca, A. Rigon, F. Basta, A. Taccone, M. Tombini, R. Iorio, M. Infantino, A. Afeltra
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Epilepsy may occur before, during or after SLE diagnosis, with a prevalence of 6.7%–14%. Recent works showed that a significant proportion of patients with not responding to antiepileptic drugs (AED)-resistant epilepsy harbour neural-specific autoantibodies. The detection of these antibodies may predict a favourable response to immunotherapy (75% of patients).<sup>1</sup> A small number of recent studies have described the existence of antibodies directed against a-NA in neuropsychiatrics SLE (NPSLE), and data are contrasting.<sup>2</sup> <h3>Objectives</h3> Evaluate the clinical features of epilepsy in patients with SLE. Evaluate any clinical-instrumental differences in epilepsy in patients diagnosed with epilepsy prior to many years of SLE. Evaluate antibodies associated with neurological phenotypes. <h3>Methods</h3> We retrospectively evaluated a SLE cohort for epileptic seizures. We single out 11 epileptic SLE patients (about 10%). A control group of 10 SLE patients with no NPSLE was matched for sex and age. Sera patients were tested for: ANA, a-ds-DNA, a-ENA, LAC, anticardiolipin IgG and IgM, anti-β2-glycoprotein IgG and IgM, a-nucleosomes, a-ribosomal. All sera were evaluated for the presence of autoantibodies directed to neural antigens by indirect immunofluorescence on frozen sections of mouse brain, cell-based assays (a-NA, a-NMDA). <h3>Results</h3> In our cohort of SLE patients with epilepsy we confirm the association between SLE and epilepsy of the mesial temporal lobe (MTLE). Six patients had epilepsy at least 5 years prior to SLE diagnosis (average 11.6 years)., the presence of minor symptoms suggestive of SLE (eg arthralgia, rash.) was reported many years before immunological diagnosis. Moreover seizure frequency was achieved when they started immunosuppressive drugs. Anti-NA antibodies were present in 6/11 (54%) of patients with SLE/epilepsy compared with 2/10 (20%) of the control group (p=0.05). We obtained specificity 0.80 (95% CI 0.44–0.97), and sensitivity 0.54 (95% CI 0.23–0.82). Among the other antibodies studied, we have not found any statistically significant difference between the two groups. <h3>Conclusions</h3> Anti-NA antibodies could be a useful biomarker of NPSLE, allowing a more precocious diagnosis and therefore a more early therapeutic intervention with improvement of long-term prognosis and quality of life. <h3>References</h3> [1] Iorio R, et al. 2015Eur J Neurol [2] Kampylafka EI, et al. 2016Lupus <h3>Disclosure of Interest</h3> None declared
SAT0491 Clinical features and complications in a large international cohort of antimda5 patients: a challenge for the future
Authors: F. Locatelli, S. Castaneda, G. Zanframundo, A. Meyer, F. Iannone, M. Giannini, S. Prieto Gonzalez, C. Scire, M. Govoni, C. Montecucco, F. Furini, J. Vega, H. Lorenz, G. Emmi, I. Villa Blanco, S. Barsotti, R. Neri, M. Mosca, A. Pesci, G. Dei, M.F. Moraes-Fontes, D. Cammelli, P. Parronchi, B. Biagioni, A. Mathieu, M. Piga, C. Nannini, R. Gerli, E. Bartoloni Bocci, J.E. Fonseca, R. Marques, F. Romero Bueno, L. Damian, M. Belliato, S. De Vita, L. Quartuccio, F. Maurier, J. Cifrian, G. Zampogna, A. Mera Varela, N. Perez Gomez, P. Da Silva, C.J. Matos Costa, J. Rojas-Serrano, L. Vazquez, U. Schneider, E. Feist, I. Cavazzana, F. Franceschini, G. Cagnotto, I. Chiapparoli, S. Bellando-Randone, M. Matucci-Cerinic, R. Caporali, M.A. Gonzalez-Gay, L. Cavagna
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Anti-MDA5 antibodies are a known set of antibodies observed mainly in dermatomyositis, typically associated with cutaneous involvement, presence and often rapid progression (RP) of interstitial lung disease (ILD) and amyopathic muscle involvement. Despite the increased attention, described cohorts involves only a limited number of cases <h3>Objectives</h3> to define clinical characteristics of a large cohort of anti-MDA5 antibodies positive patients <h3>Methods</h3> Retrospective assessment of anti-MDA5 positive patients from centres referring to our group <h3>Results</h3> 82 anti-MDA5 positive cases (56 females) were collected. In median: onset age was 44 Y (IQR 22.57), diagnostic delay 4 Mo (IQR 1–10), follow-up 13 Mo (IQR 3–43). Fifty-three patients had ILD, that was RP in 24 cases (15 at ILD onset, 9 after ILD onset). Fifthteen ILD patients were admitted in Intensive Care Unit (ICU): 4 were treated with Extracorporeal-Membrane-Oxygenation, 7 with mechanical-invasive and 2 with mechanical-non-invasive ventilation. Forthy-nine patients had muscle involvement (39 symptomatic), 42 arthritis, 54 cutaneous involvement, 9 history of malignancy. Twelve patients died (ILD=7, ILD and sepsis=3, neoplasia=1, not specified=1), 7 of those in ICU <h3>Conclusions</h3> In our cohort, ILD was the most frequent finding. A RP of ILD was common, occurring also in ILD with symptomatic/chronic onset. The low rate of survival in ICU raised the problem of follow up and early treatment of ILD. In our cohort arthritis was common and muscle involvement mainly symptomatic. Finally, the high percentage of observed malignancies suggests a careful neoplastic screening and follow up <h3>Reference</h3> [1] Labrador-Horrillo M, et al. J Immunol Res2014;2014:290797. <h3>Disclosure of Interest</h3> None declared
The Role of Innate Immune Cells in Nonalcoholic Steatohepatitis
Authors: Jingjing Cai, Xiao‐Jing Zhang, Hongliang Li
Journal: Hepatology (2019)

Inflammation and metabolic dysfunction are hallmarks of nonalcoholic steatohepatitis (NASH), which is one of the fastest‐growing liver diseases worldwide. Emerging evidence indicates that innate immune mechanisms are pivotal drivers of inflammation and other pathological manifestations observed in NASH, such as hepatosteatosis, insulin resistance (IR), and fibrosis. This robust innate immune reaction is intrinsic to the liver, which is an important immunological organ that contains a coordinated network of innate immune cells, including Kupffer cells (KCs), dendritic cells (DCs), and lymphocytes. Hepatocytes and liver sinusoidal endothelial cells (LSECs) are not formally innate immune cells, but they take on immune cell function when stressed. These cells can sense excess metabolites and bacterial products and translate those signals into immune responses and pathological hepatic changes during the development of NASH. In this review, we take a historical perspective in describing decades of research that aimed to identify the key molecular and cellular players in the innate immune system in the setting of NASH. Furthermore, we summarize the innate immune cells that are involved in the progression of NASH and illustrate how they sense disturbances in circulating metabolic factors by innate immune receptors and subsequently initiate the intercellular signaling cascades that lead to persistent inflammation and progression of hepatic complications.
Abstract 15482: Medin Amyloid Protein-Induced Human Leptomeningeal Arteriole Endothelial Dysfunction and Pro-Inflammatory Signaling are Reversed by Monosialoganglioside Nanoliposomes
Authors: Seth Truran, Nina Karamanova, Jillian Madine, Hannah Davies, Diana Guzman-Villanueva, Geidy Serrano, Daniel A Franco, Thomas Beach, Volkmar Weissig, Raymond Q Migrino
Journal: Circulation (2017)

Background: Medin is a 50 amino acid peptide that forms amyloid deposits in the vasculature. It is the most common human amyloid protein and was reported to be present in almost all tested patients...
AB0402 Recent onset rheumatoid arthritis have and increased left anterior descending coronary artery wall thickness: evidence of subclinical coronary artery disease
Authors: S. Hannawi, I. Al Salmi, H. Hannawi
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Rheumatoid arthritis (RA) is associated with increased cardiovascular disease (CVD). Using different methods, presence of sub-clinical atherosclerosis changes have been reported in RA. As no previous study has measured left anterior descending (LAD) coronary artery thickness in RA <h3>Objectives</h3> this study aimed to investigates atherosclerotic changes of coronary artery in early RA of 12 months of symptom onset. <h3>Methods</h3> 15 RA patients and 20 control subjects who matched 10 RA participants were included in the study. Demographic details, RA characteristics, and laboratory values of 15 RA patients at first presentation. None of the patients or the control participants had previous CVD/cerebrovascular events or diabetes and matched 10 of the RA group for age and sex. LAD coronary artery wall thickness compared between RA and their matched control. Among early RA patients, Correlation was assessed between LAD coronary artery wall thickness and the demographic features, RA activity features, and cardiovascular risk factors. <h3>Results</h3> Within early RA, LAD coronary artery wall thickness was related to Disease Activity Score (p=0.025, β-coefficient 0.066, CI:0.010–0.122) and to the patient global assessment of disease activity at RA onset (p=0.006, β-coefficient 0.003, CI:0.001–0.005)), in a positive linear relationship. LAD wall thickness was thicker among RA patients with rheumatoid factor (RF) positive (p=0.015, CI:0.53–0.66). LAD coronary artery wall thickness was increased in early RA compare to controls (0.61±0.04 mm (CI:0.52–0.70); and 0.48±0.08 mm (CI:0.44–0.51) respectively, p=0.001. <h3>Conclusions</h3> Early RA patients have increased coronary arteries atherosclerotic burden compared to controls matched for age, and sex. Rheumatoid factor positivity, high Disease Activity Score and Patient Global Assessment of disease activity were associated with coronary wall thickness. <h3>Disclosure of Interest</h3> None declared
Abstract 18106: Community-Based Analysis of Sudden Cardiac Death in Young Adults Age 18-34, in a Large US Population
Authors: Kyndaron Reinier, Carmen Teodorescu, Audrey Uy-Evanado, Harpriya Chugh, Ronald Mariani, Jo Ayala, Katherine Jerger, Gregory Nichols, Karen Gunson, Jonathan Jui, Sumeet S Chugh
Journal: Circulation (2012)

Introduction: Sudden cardiac death in young adults is rare and since existing studies have few subjects, there is a lack of detailed information. We hypothesized that analysis from a large community-based investigation would provide novel mechanistic information. Methods: In an ongoing, community-based study of prospectively-identified SCD cases in the Northwest US (2002 - 2011), cases aged 18 - 34 were compared with patients aged 35 - 59, and 60 or older. All cases were adjudicated by review of arrest circumstances and physician records. Cases with non-cardiac causes of SCD and terminal illnesses were excluded. Clinical history prior to arrest across the three age groups was compared using χ2 tests. Results: Patients aged 18-34 (n=134, 59% male) made up 5% of the total 2740 cases ascertained, while patients aged 35-59 made up 36% (n=996, 75% male) and patients 60 or older made up 59% (n=1610, 62% male). Young patients were less likely to have physician records available for review (51% vs. 59% and 69%, r...
Abstract 15931: Fighting CAVD: Secreted Klotho Protects Osteoclastogenesis via Regulation of Canonical NF-κB (P65) Pathway and RANK-RANKL/OPG Axis
Authors: Jianglei Chen, Kai Chen, Yi Lin, Zhongjie Sun
Journal: Circulation (2017)

Background: Aortic valve calcification and aortic stenosis is one of the most prevalent forms of cardiovascular disease in the developed countries. Currently there is no effective therapeutic treat...
Efficacy of Mogamulizumab By Prior Systemic Therapy in Patients with Previously Treated Cutaneous T-Cell Lymphoma: Post Hoc Analysis from the Phase 3 Mavoric Study
Authors: Pier Luigi Zinzani, Steven M. Horwitz, Youn H. Kim, Alison J. Moskowitz, Pierluigi Porcu, Julia Scarisbrick, Mollie Leoni, Karen Dwyer, Wei Sun, Elena Nikonova, Martine Bagot
Journal: Blood (2018)
Association of Transvaginal Mesh Complications With the Risk of New-Onset Depression or Self-harm in Women With a Midurethral Sling
Authors: Blayne Welk, Jennifer Reid, Erin Kelly, You Maria Wu
Journal: JAMA Surgery (2019)

This study evaluates 12 years’ worth of clinical data on transvaginal mesh complications and depression or self-harm in women who received a midurethral mesh sling.