tbuckley/cabot-search huggingface dataset:
Randomized phase III trial of erlotinib vs. docetaxel in patients with advanced squamous cell non-small cell lung cancer (SqNSCLC) failing first line platinum based doublet chemotherapy stratified by VeriStrat Good vs VeriStrat Poor: The European Thoracic Oncology Platform (ETOP) EMPHASIS trial.
Authors: Solange Peters, Egbert F. Smit, Urania Dafni, Santiago Ponce Aix, Bartomeu Massuti, Oliver Gautschi, Linda Coate, Ana López Martín, Robbert van Heemst, Thierry Berghmans, Peter Meldgaard, Manuel Cobo Dols, Javier Garde Noguera, Irene Claudia Floriani, Marie Kassapian, Yojena Chittazhathu Kurian Kuruvilla, Adriana Gasca-Ruchti, Christoph Zielinski, Vanesa Gregorc, Rolf A. Stahel
Journal: Journal of Clinical Oncology (2015)

8049 Background: Docetaxel (D) or Erlotinib (E) are registered second-line treatments for EGFR wild type NSCLC. Previous studies suggested a predictive value of the serum proteomic VeriStrat test (VS), assigning a good (VSG) or poor (VSP) classification in second-line therapy of patients (pts.) with NSCLC. EMPHASIS aimed at exploring a predictive interaction in SqNSCLC pts. The trial closed prematurely due to low accrual. Methods: EMPHASIS is a randomized phase III multicenter trial exploring the differential activity of second line E vs D on progression-free survival (PFS) in VSG vs VSP SqNSCLC. The expected hazard ratio (HR) of E vs D was 0.675 for the VSG patients (median PFS, E: 4.0 and D: 2.7 mo.), and 1.23 for the VSP patients (median PFS, E: 2.2 and D: 2.7 mo.). A sample size of 500 was needed to achieve 86% power for testing the expected interaction HR of 1.82 at a two-sided p-value of 0.05. Pts were randomized to receive treatment E150 mg p.o. daily or D 75 mg/m2 i.v. on day 1 of each 21 day cycle. Results: From 1/2013 to 1/2014, a total of 80 patients were randomized to the study, with 72.5% categorized as VSG. Median age was 69 years with the majority being male (83%), smokers (94%), and having good performance status (91%). No unexpected serious adverse events (SAEs) were observed in either treatment arm. All pts are off treatment (median time to treatment failure: 2.1 mo.), while 73 progression events (median PFS: 2.7 mo.) and 56 deaths (median OS: 7.1 mo.) were observed. Median PFS for VSG is 4.1 and 1.6 mo. under D and E respectively, and 1.9 and 2.1 mo. for VSP pts (HR = 1.04, interaction p-value = 0.94). Median OS for VSG is 7.8 and 8.4 mo. for D and E and 4.4 and 5.2 mo. for VSP. Conclusions: The final analysis of EMPHASIS did not show a differential activity on PFS of E vs D in SqNSCLC pts stratified by VS status. These results are at variance with trial assumptions and previous studies. In addition to the EMPHASIS results (PFS & OS), we will present a combined PFS/OS analysis with the subgroup of SqNSCLC from the PROSE study. EudraCT number: 2012-001896-35. Clinical trial information: NCT01652469.
Empowering patients to make informed choices
Authors: Kenneth Y-K Wong, Suzanne Wong
Journal: BMJ (2019)

Mathew’s column on giving statins to patients over 75 was thought provoking, but we are concerned that readers may be tempted to withhold lifesaving drugs from older patients without giving ample time and information to empower patients to make an informed choice.1

I (KW) have had numerous conversations with patients saying that ramipril gives …
The Role of VWF, FVIII, ADAMTS13 and Inflammatory Response in the Outcome of Acute Ischemic Stroke Mechanical Thrombectomy Procedure
Authors: Jaromir Gumulec, Václav Procházka, Tomáš Jonszta, Daniel Czerný, Martin Roubec, Jirka Mačák, Petra Kovářová, Ivo Lochman, David Kaspřák, Roman Hajek
Journal: Blood (2017)
A Time-Series Analysis of Firearm Purchasing After Mass Shooting Events in the United States
Authors: Gina Liu, Douglas J. Wiebe
Journal: JAMA Network Open (2019)

<h3>Importance</h3> Increased understanding of public response to mass shootings could guide public health planning regarding firearms. <h3>Objectives</h3> To test the hypothesis that mass shootings are associated with gun purchasing in the United States and to determine factors associated with gun purchasing changes. <h3>Design and Setting</h3> In a cross-sectional study, monthly data on US background checks for all firearm purchases, handgun permits, and long gun permits between November 1, 1998, and April 30, 2016, were obtained from the National Instant Criminal Background Check System. All mass shootings resulting in 5 or more individuals injured or killed during the study period were also identified. Interrupted autoregressive integrated moving average time-series modeling was used to identify events associated with changes in gun purchase volume. Then, logistic regression was used to identify event characteristics associated with changes in gun purchases. Analyses were performed between June 6, 2016, and February 5, 2019. <h3>Exposures</h3> For the time-series analysis, each mass shooting was modeled as an exposure. In the logistic regression, examined factors were the shooter's race/ethnicity, the region in the United States in which a shooting occurred, whether a shooting was school related, fatalities, handgun use, long gun use, automatic or semiautomatic gun use, media coverage level, and state political affiliation. <h3>Main Outcomes and Measures</h3> Identification of major mass shootings significantly associated with changes in gun purchases, and the identification of event-specific factors associated with changes in gun purchases. <h3>Results</h3> Between November 1998 and April 2016, 124 major mass shootings and 233 996 385 total background checks occurred. A total of 26 shootings (21.0%) were associated with increases in gun purchases and 22 shootings (17.7%) were associated with decreases in gun purchasing. Shootings receiving extensive media coverage were associated with handgun purchase increases (odds ratio, 5.28; 95% CI, 1.30-21.41;<i>P</i> = .02). Higher-fatality shootings had an inverse association with handgun purchase decreases (odds ratio, 0.73; 95% CI, 0.53-1.00;<i>P</i> = .049). <h3>Conclusions and Relevance</h3> The findings of this study suggest an association between mass shootings and changes in gun purchases, observed on a comprehensive timescale. Identification of media coverage and fatalities as significant factors underlying this association invites further study into the mechanisms driving gun purchase changes, holding implications for public health response to future gun violence.
Website of the Week: SARS revisited
Authors: Fabian Waechter
Journal: BMJ (2003)

We last looked at internet coverage of severe acute respiratory syndrome (SARS) only four weeks ago (http://bmj.com/cgi/content/full/326/7395/937/a). But since then readers have brought a number of other sites to our attention. With such a fast developing and ever changing subject as the SARS outbreak, the explosion of new sites is not surprising. This is one of the fundamental strengths of the internet, along with highly visible, fast updates, which are unattainable by the print media. But in the case of something like complex health information, the internet also has its weaknesses. One of these is the lack of “editorial” information about the sites that we surf.

Many of the sites on SARS that readers recommended look (and are) very good. It is another strength of the internet that it is not restricted to professional media people or international associations like the World Health Organization. Anybody can put up information. It might as well be you or me. Consequently there is an abundance of private pages about SARS and many of them offer a good selection of information and hyperlinks. However, only a few of them are explicit about the people or organisations behind them (whereas if you go to http://bmj.com/aboutsite you will soon know everything about us).

Sites such as www.sarsnewswire.com or www.urbaniSARS.com are very slick—they look great and contain a lot of useful and well selected information and resources about SARS. However, neither site tells us anything about the people who run them, why they produce them, and, no less important, where in the world they do so.

Another pitfall, especially for the uninitiated, is the false security of posh domain names. Rare visitors to the internet, perhaps driven by fear of SARS, might go for www.sars.com, a presumably reasonable choice. They will, however, find tabloid style information, funny or rather scary pictures, and definitely no information whatsoever of how, where, or why this important piece of human knowledge was created. And, most importantly, we do not learn who created it. I wonder why.
Correction: Epigenetic Regulation of NAMPT by NAMPT-AS Drives Metastatic Progression in Triple-Negative Breast Cancer
Authors: Hanwen Zhang, Ning Zhang, Ying Liu, Peng Su, Yiran Liang, Yaming Li, Xiaolong Wang, Tong Chen, Xiaojin Song, Yuting Sang, Yi Duan, Jiashu Zhang, Lijuan Wang, Bing Chen, Wenjing Zhao, Haiyang Guo, Zhaojian Liu, Guohong Hu, Qifeng Yang
Journal: Cancer Research (2021)

In the original version of [this article][1] ([1][2]), the authors inadvertently incorporated the incorrect image in the sh8 migration panel in Fig. 5C. Likewise, incorrect images were included in Supplementary Fig. S8C for the MDA-MB-231 invasion and MDA-MB-468 migration panels in the pcDNA3.1+NC
Unbiased Pathogen Detection and Host Gene Profiling for Conjunctivitis
Authors: Prajna Lalitha, Gerami D. Seitzman, Ritesh Kotecha, Armin Hinterwirth, Cindi Chen, Lina Zhong, Milo E. Cummings, Elodie Lebas, Malaya K. Sahoo, Benjamin A. Pinsky, Thomas M. Lietman, Thuy Doan
Journal: Ophthalmology (2019)
Abstract 14465: C1q/TNF-Related Protein-13 (CTRP13) Protects Against Myocardial Injury following Ischemia-Reperfusion via the Phosphatidyl-Inositol 3-Kinase (PI3K) Pathway
Authors: Vanlata Patel, Bee Kang Tan, Raghu Adya, Harpal S Randeva
Journal: Circulation (2013)

Background: C1q/TNF-Related Protein-13 (CTRP13) is a novel insulin sensitizing adipokine by promoting glucose uptake in peripheral tissues. To date, the impact of CTRP13 on the cardiovascular syste...
Single-cell imaging of CAR T cell activity in vivo reveals extensive functional and anatomical heterogeneity
Authors: Marine Cazaux, Capucine L. Grandjean, Fabrice Lemaître, Zacarias Garcia, Richard J. Beck, Idan Milo, Jérémy Postat, Joost B. Beltman, Eleanor J. Cheadle, Philippe Bousso
Journal: The Journal of Experimental Medicine (2019)

CAR T cells represent a potentially curative strategy for B cell malignancies. However, the outcome and dynamics of CAR T cell interactions in distinct anatomical sites are poorly understood. Using intravital imaging, we tracked interactions established by anti-CD19 CAR T cells in B cell lymphoma–bearing mice. Circulating targets trapped CAR T cells in the lungs, reducing their access to lymphoid organs. In the bone marrow, tumor apoptosis was largely due to CAR T cells that engaged, killed, and detached from their targets within 25 min. Notably, not all CAR T cell contacts elicited calcium signaling or killing while interacting with tumors, uncovering extensive functional heterogeneity. Mathematical modeling revealed that direct killing was sufficient for tumor regression. Finally, antigen-loss variants emerged in the bone marrow, but not in lymph nodes, where CAR T cell cytotoxic activity was reduced. Our results identify a previously unappreciated level of diversity in the outcomes of CAR T cell interactions in vivo, with important clinical implications.
The Gout Wars
Authors: Burton Abrams
Journal: Annals of Internal Medicine (2019)

Letters2 April 2019The Gout WarsBurton Abrams, MSBurton Abrams, MSElkins Park, Pennsylvania (B.A.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L19-0039 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I listened with interest to Centor and McLean's podcast (1) about the differences between the American College of Physicians' and American College of Rheumatology's recommendations for the treatment of gout. Both organizations miss a major underlying cause of gout that would greatly affect its treatment.One aspect of gout that is too often overlooked in guidelines and practice is that most flares begin during sleep. The connection between sleep and gout has been known at least since Dr. Thomas Sydenham wrote about it in 1683. Choi and colleagues' 2015 study (2) confirms Dr. Sydenham's observation. This connection ...References1. Centor RM, McLean RM. Annals On Call – The gout wars: when guidelines collide. Ann Intern Med. 2018;169:OC1. [PMID: 30083719]. doi:10.7326/A18-0001 LinkGoogle Scholar2. Choi HK, Niu J, Neogi T, Chen CA, Chaisson C, Hunter D, et al. Nocturnal risk of gout attacks. Arthritis Rheumatol. 2015;67:555-62. [PMID: 25504842] doi:10.1002/art.38917 CrossrefMedlineGoogle Scholar3. Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell J. Kelley's Textbook of Rheumatology. 9th ed. Philadelphia: Elsevier; 2013. Google Scholar4. Cantalejo Moreira M, Veiga Cabello RM, García Díaz V, Racionero Casero MA, Zapatero Gaviria A. Gout, hyperuricaemia, sleep apnoea-hypopnoea syndrome and vascular risk. Rheumatology (Oxford). 2013;52:1619-22. [PMID: 23418048] doi:10.1093/rheumatology/kes418 CrossrefMedlineGoogle Scholar5. Koga S, Ikeda S, Yasunaga T, Nakata T, Maemura K. Effects of nasal continuous positive airway pressure on the glomerular filtration rate in patients with obstructive sleep apnea syndrome. Intern Med. 2013;52:345-9. [PMID: 23370742] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Elkins Park, Pennsylvania (B.A.)Disclosures: The author has disclosed no conflicts of interest. The form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L19-0039. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAnnals On Call - The Gout Wars: When Guidelines Collide Robert M. Centor and Robert M. McLean Metrics 2 April 2019Volume 170, Issue 7Page: 506KeywordsBloodGoutPolysomnographyRenal diseasesRespiratory failureRheumatologySleepSleep apneaStormsUric acid ePublished: 2 April 2019 Issue Published: 2 April 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Image Gallery: <i>In vivo</i> fluorescence‐advanced videodermatoscopy for the characterization of skin melanocytic pigmented lesions
Authors: F. Scarfì, A. Gori, A. Topa, L. Trane, E. Dika, P. Broganelli, D. Massi, V. De Giorgi
Journal: British Journal of Dermatology (2019)
Abstract 18976: Progenitor Cell Ploidy: The Regulator of Regenerative Fate
Authors: KATHLEEN BROUGHTON, Pearl Quijada, Jessica Wang, Megan Monsanto, Natalie Gude, Mark Sussman
Journal: Circulation (2015)

Cellular therapy is an emerging interventional strategy to treat heart failure and has demonstrated tremendous potential in recent years. Use of endogenous stem cells found within the heart, cardiac progenitor cells (CPC), has prompted intense basic research in multiple experimental animal models as well as clinical trials in heart failure patients. Scientifically, the field continues to unravel mechanisms of CPC involvement in remodeling and repair of the heart under both normal and pathologic conditions. Research has been primarily performed in mouse models, which represent the fundamental experimental platform for a vast array of regenerative medicine research. Given the importance of mouse models for stem cell research, understanding fundamental differences between mouse and human stem cell biology are essential. Our findings show that adult murine CPCs contain tetraploid (4n) chromosome content in contrast to the normally expected diploid (2n) chromosome content as found in human CPCs by karyotype analyses. To expand the significance of this finding, CPCs were isolated from standard lab mice (FVB and C57), human telomere-length equivalent mice (CAST and SPRET) and an early onset senescence mouse (SAMP6), which revealed mononuclear tetraploid content as characterized through a combination of flow cytometry and confocal microscopy analysis using antibodies and fluorescence in situ hybridization (FISH) techniques. In comparison, isolated murine ckit+ bone marrow stem cells possess mononuclear diploid content through similar analysis. The ploidy content of endogenous murine and human CPCs was investigated in situ with heart tissue sections with comparable ploidy determinations to that of cultured CPCs. Furthermore, the unique tetraploid content of CPCs within the murine heart is reinforced by comparison with ckit+ progenitor cells of secondary tissues (intestine and bone) that exhibit diploid chromosome content. These studies reveal a fundamental difference between human and murine CPCs that is essential for functional regenerative potential since regenerative tissues commonly are polyploid. Future directions will focus on defining the advantage of polyploidy in mediating regeneration.
Correction to: Incidence, mortality, and temporal patterns of oropharyngeal cancer in China: a population‐based study
Authors: Jie Liu, Xu‐li Yang, Si‐Wei Zhang, Li‐Ping Zhu, Wan‐Qing Chen
Journal: Cancer Communications (2019)

In the original publication of this article [1], the number of death cases in ‘Materials and methods’ section is incorrect.
Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties
Authors: Xiangqian Kong, Jie Chen, Wenbing Xie, Stephen M. Brown, Yi Cai, Kaichun Wu, Daiming Fan, Yongzhan Nie, Srinivasan Yegnasubramanian, Rochelle L. Tiedemann, Yong Tao, Ray-Whay Chiu Yen, Michael J. Topper, Cynthia A. Zahnow, Hariharan Easwaran, Scott B. Rothbart, Limin Xia, Stephen B. Baylin
Journal: Cancer Cell (2019)
Rwanda launches a 5-year national hepatitis C elimination plan: A landmark in sub-Saharan Africa
Authors: Grace Umutesi, Fabienne Shumbusho, Fredrick Kateera, Janvier Serumondo, Jules Kabahizi, Emmanuel Musabeyezu, Alida Ngwije, Neil Gupta, Sabin Nsanzimana
Journal: Journal of Hepatology (2019)
Outbreak of Cyanide Poisoning Caused by Consumption of Cassava Flour — Kasese District, Uganda, September 2017
Authors: Phoebe H. Alitubeera, Patricia Eyu, Benon Kwesiga, Alex R. Ario, Bao-Ping Zhu
Journal: MMWR Morbidity and Mortality Weekly Report (2019)

Cassava (Manihot esculenta), an edible tuberous root that is resistant to drought, diseases, and pests, is a major source of carbohydrates in tropical areas, the second most widely grown and consumed food in Uganda after bananas, and a staple in the diet for approximately 57% of the Uganda population (Figure 1) (1).On September 5, 2017, a funeral was held in Kasese District in western Uganda.Following the funeral, 33 persons with symptoms that included diarrhea, vomiting, and abdominal pains were admitted to Bwera Hospital in Kasese District.On September 8, the Uganda Ministry of Health received notification from the Kasese District health team regarding this outbreak of suspected food poisoning.An investigation to determine the cause of the outbreak and recommend control measures revealed that the outbreak resulted from consumption of a cassava dish made by combining hot water with cassava flour.The implicated batch of cassava flour was traced back to a single wholesaler and found to contain high cyanogenic content.Informed by the investigation findings, police confiscated all cassava flour from retailers identified as the patients' source of the flour.Health education about cyanide poisoning from cassava and the need to adequately process cassava to reduce cyanogenic content was conducted by public health officials.
Interactions Among Dietary Fat, Protein, and Cholesterol in Atherosclerosis-Susceptible Pigeons
Authors: HUGH B. LOFDAND, THOMAS B. CLARKSON, HAROLD O. GOODMAN
Journal: Circulation Research (1961)

In a 3x 2x 2 factorially designed experiment, White Carneau pigeons were kept nine months on diets containing three levels of protein (5 per cent, 15 per cent, and 30 per cent casein) and two types of dietary fat (10 per cent oil or 10 per cent hydrogenated coconut oil). Identical groups received, in addition, 0.25 per cent cholesterol. Analysis for serum cholesterol, and for cholesterol, total lipids, and phospholipids in the aorta, and measurements of atherosclerotic index were carried out. The data were subjected to statistical evaluation by analysis of variance. The addition of cholesterol to the diets elevated the level of cholesterol in the serum and the aorta and increased the severity of atherosclerosis. A significant interaction was found to exist between the type of fat in the diet and the presence or absence of cholesterol. Among cholesterol-fed birds only, corn oil exerted a significant cholesterol-lowering action. Suggestive evidence was obtained for the concept that the severity of atherosclerosis is influenced by the type of dietary fat, the level of protein, and the presence or absence of cholesterol in the diet, and that bio-logical interactions exist among these dietary variables.
Correction to: 33rd Annual Meeting &amp; Pre-Conference Programs of the Society for Immunotherapy of Cancer (SITC 2018)
Authors: Sneha Berry, Nicolas Giraldo, Peter Nguyen, Benjamin Green, Haiying Xu, Aleksandra Ogurtsova, Abha Soni, Farah Succaria, Daphne Wang, Charles Roberts, Julie Stein, Elizabeth Engle, Drew Pardoll, Robert Anders, Tricia Cottrell, Janis M. Taube, Ben Tran, Mark Voskoboynik, James Kuo, Yung-Lue Bang, Hyun-Cheo Chung, Myung-Ju Ahn, Sang-We Kim, Ayesh Perera, Daniel Freeman, Ikbel Achour, Raffaella Faggioni, Feng Xiao, Charles Ferte, Charlotte Lemech, Funda Meric-Bernstam, Theresa Werner, Stephen Hodi, Wells Messersmith, Nancy Lewis, Craig Talluto, Mirek Dostalek, Aiyang Tao, Sarah McWhirter, Damian Trujillo, Jason Luke, Chunxiao Xu, None BoMarelli, Jin Qi, Guozhong Qin, Huakui Yu, Molly Jenkins, Kin-Ming Lo, Joern-Peter Halle, Yan Lan, Matthew Taylor, Nicholas Vogelzang, Allen Cohn, Daniel Stepan, Robert Shumaker, Corina Dutcus, Matthew Guo, Emmett Schmidt, Drew Rasco, Marcia Brose, Nicholas Vogelzang, Christopher Di Simone, Sharad Jain, Donald Richards, Carlos Encarnacion, Drew Rasco, Robert Shumaker, Corina Dutcus, Daniel Stepan, Matthew Guo, Emmett Schmidt, Matthew Taylor, Nicholas Vogelzang, Carlos Encarnacion, Allen Cohn, Christopher Di Simone, Drew Rasco, Donald Richards, Matthew Taylor, Corina Dutcus, Daniel Stepan, Robert Shumaker, Matthew Guo, Emmett Schmidt, James Mier, Jeongshin An, Yeun-yeoul Yang, Won-Hee Lee, Jinho Yang, Jong-kyu Kim, Hyun Goo Kim, Se Hyun Paek, Jun Woo Lee, Joohyun Woo, Jong Bin Kim, Hyungju Kwon, Woosung Lim, Nam Sun Paik, Yoon-Keun Kim, Byung-In Moon, Filip Janku, David Tan, Juan Martin-Liberal, Shunji Takahashi, Ravit Geva, Ayca Gucalp, Xueying Chen, Kulandayan Subramanian, Jennifer Mataraza, Jennifer Wheler, Philippe Bedard
Journal: Journal for ImmunoTherapy of Cancer (2019)

After publication of this supplement [1, 2], it was brought to our attention that due to an error authors were missing in the following abstracts. This has now been included in this correction.