tbuckley/cabot-search huggingface dataset:
Left- versus right-side metastatic colorectal cancer: Teasing out clinicopathologic drivers of disparity in survival.
Authors: Shehara Ramyalini Mendis, Belinda Lee, Margaret Lee, Rachel Wong, Suzanne Kosmider, Jeremy David Shapiro, Desmond Yip, Simone Anne Steel, Louise M. Nott, Ross Jennens, Lara Rachel Lipton, Matthew E. Burge, Kathryn Maree Field, Sumitra Ananda, Sophie Beck, Hui-Li Wong, Peter Gibbs
Journal: Journal of Clinical Oncology (2019)

623 Background: Patients with metastatic colorectal cancer (mCRC) arising from a right sided colorectal cancer (RC) have an inferior survival versus patients with a left sided colorectal cancer (LC). Previous analyses have suggested that multiple factors contribute. Methods: The Treatment of Recurrent and Advanced Colorectal Cancer (TRACC) Registry has prospectively captured comprehensive data on consecutive mCRC patients since 2009. For this analysis LC were defined as primary tumors at or distal to the splenic flexure and included rectal cancers. We analysed patient, tumor, treatment and outcome data. Results: Of 2306 patients enrolled from July 2009–March 2018, median age 67 years (range 18–100), 1559 (67.6%) had a LC. Patients with a RC were older (median 71 vs 65 years, p &lt; 0.001), more likely to be female (50.2% vs 36.9%, p &lt; 0.001) and to have a Charlson score ≥ 3 (67.5% vs 54.6%, p &lt; 0.001). More common in RC, where tested, were BRAF mutations (22.3% vs 7.2%, p &lt; 0.001) and deficient mismatch repair (6.4% vs 1.5%, p &lt; 0.001), but not RAS mutations. Peritoneal metastases were more frequent in RC (29.7% vs 14.9%, p &lt; 0.001). RC patients were more likely to have their primary tumor resected (77.9% vs 70.6%, p &lt; 0.001) and to receive less first-line chemotherapy (72.2% vs 78.7%, p = 0.001). Progression-free survival on first-line systemic therapy was inferior for RC patients (8.1 vs 10.8 months, HR 1.38, p &lt; 0.001). Median overall survival (OS) for all RC patients was inferior (19.6 vs 27.5 months, HR 1.44, p &lt; 0.001). Primary side remained a significant factor for OS in multivariate analysis. Conclusions: Our data confirms the poor prognosis associated with RC, contributed to by multiple factors. However, primary side remains significant even when adjusting for these, indicating the existence of further as yet undefined differences. [Table: see text]
Very Poor Outcome of Patients with Relapsed/Refractory Aggressive B Cell Lymphoma after Autologous Stem Cell Transplantation (ASCT) or High Dose of Methotrexate and Cytarabine (HD-MTX/ARA-C) Regimens in the Clinical Care Setting
Authors: Nicola Bianchetti, Alessandra Tucci, Alessandro Re, Chiara Pagani, Chiara Cattaneo, Maria Miscio, Fabio Facchetti, Simona Fisogni, Piera Balzarini, Domenico Albano, Giovanni Bosio, Francesco Bertagna, Giuseppe Rossi
Journal: Blood (2018)
PLASMA OMENTIN SIGNIFICANTLY PREDICTS CARDIOVASCULAR EVENTS INDEPENDENTLY FROM THE PRESENCE AND EXTENT OF ANGIOGRAPHICALLY DETERMINED BASELINE CORONARY ARTERY DISEASE
Authors: Christoph Saely, Andreas Leiherer, Axel Muendlein, Alexander Vonbank, Philipp Rein, Kathrin Geiger, Heinz Drexel
Journal: Journal of the American College of Cardiology (2015)
Resolution of Hypoxic Tissue in Cerebellar Hemispheres After Arterial Bypass Surgery in a Patient With Symptomatic Bilateral Vertebral Artery Occlusion
Authors: Kohki Oikawa, Masakazu Kobayashi, Takaaki Beppu, Kazunori Terasaki, Kuniaki Ogasawara
Journal: Clinical Nuclear Medicine (2019)

A 48-year-old man experienced recurrent vertigo refractory to antiplatelet medications. Cerebral angiography showed occlusion of bilateral vertebral arteries with poor collateral circulation. PET using O2 gas showed reduced blood flow and metabolic rate of oxygen and elevated oxygen extraction fraction in bilateral cerebellar hemispheres. Subsequent F-FRP170 (1-(2-F-fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole) PET, which depicts hypoxic but viable tissue, revealed elevated tracer uptake in the same regions. After superficial temporal artery-posterior cerebral artery anastomosis, O-gas PET showed normalization of blood flow, metabolic rate of oxygen, and oxygen extraction fraction in bilateral cerebellar hemispheres. Abnormally elevated F-FRP-170 uptake was also resolved in those regions.
Abstract 19957: Chronic Infusion of Growth Hormone Releasing Hormone Prevents Heart Failure With Preserved Ejection Fraction Phenotype Development in Murine Cardiomyocytes by Reducing Myofilament Sensitivity to Calcium
Authors: Raul A Dulce, Rosemeire M Kanashiro Takeuchi, Lauro M Takeuchi, Alessandro G Salerno, Wayne Balkan, Renzhi Cai, Andrew V Schally, Joshua M Hare
Journal: Circulation (2017)

Introduction: Heart failure with preserved ejection fraction (HFpEF) represents ~50% of heart failure cases and is characterized by impaired relaxation, ventricular stiffening and fibrosis. Growth ...
HBV antiviral immunity: not all CD8 T cells are born equal
Authors: Antonio Bertoletti, Patrick T F Kennedy
Journal: Gut (2019)

In Gut , two compelling papers1 2 provide novel insights into the complexity of HBV-specific T-cell responses through a detailed analysis of whether T-cell immunity targeting different HBV proteins in HBV-infected patients might exhibit distinct features.

CD8 T cells are a major component of antiviral immunity. Through their ability to recognise and target the cells where viral replication occurs, they can block and even terminate the spread of viral infection in the host. Their highly selective recognition is mediated by the T-cell receptor (TCR) which detects HLA-class I/viral peptide complexes on the cell surface. These protein complexes are made by short viral peptides generated by the processing of viral proteins synthesised within the infected cells (called epitopes) non-covalently associated with HLA-class I molecules. The recognition of viral peptide/HLA complexes by the specific TCR activates the CD8 T cells, which can directly lyse the virus-producing cell or secrete cytokines that inhibit virus replication occurring in the targeted cells.3 Since viruses produce different viral proteins, CD8 T cells are armed with distinct TCRs that recognise epitopes derived from different proteins, and this multispecificity of CD8 T cells should provide the host with a greater chance to effectively control the virus infection.

This is a paradigm in HBV infection, where CD8 T cells have been shown to have a crucial role in the sustained viral control4 and where the ability to mount a multispecific CD8 T-cell response against epitopes derived from different HBV proteins is present in patients with self-limited hepatitis B.5 6 Conversely, patients with chronic HBV are characterised by a defect in the number, specificity and function of HBV-specific CD8 T cells (reviewed in Bertoletti and Ferrari7).

Immunological characterisation in HBV-infected patients to date has supported this neat dichotomy of HBV-specific CD8 T-cell response in different …
Real-World Management of Myelofibrosis with Ruxolitinib: Initial Analysis of an Italian Observational Study (ROMEI)
Authors: Massimo Breccia, Paola Guglielmelli, Alessandra Malato, Francesco Mendicino, Giuseppe A. Palumbo, Carmine Selleri, Daniela Cilloni, Patrizio Mazza, Sergio Siragusa, Elisabetta Abruzzese, Roberto Latagliata, Monica Crugnola, Domenico Pastore, Giorgia Micucci, Giulia Benevolo, Mara Morelli, Francesca Palandri, Francesco Passamonti
Journal: Blood (2018)
Activation of the Non-Canonical Estrogen Receptor Gper As a Novel Therapeutic Strategy Against WaldenstrÃ¶m Macroglobulinemia
Authors: Nicola Amodio, Giada Juli, Eugenio Morelli, Maria Angelica Stamato, Maria Eugenia Gallo Cantafio, Cinzia Federico, Katia Todoerti, Emanuela Altomare, Katia Grillone, Marco Rossi, Michele Cea, Antonino Neri, Mariateresa Fulciniti, Nikhil Munshi, Pierosandro Tagliaferri, Pierfrancesco Tassone
Journal: Blood (2018)
Fast and efficient cloning of human IgE, IgG1 and IgG4 antibodies specific for beta-lactoglobulin from cow milk by Polymerase Incomplete Primer Extension (PIPE)
Authors: Christina L. Pranger, Judit F. Singer, Verena K. Koehler, Isabella Pali-Schoell, Alessandro G. Fiocchi, Kristina M. Ilieva, Sophia N. Karagiannis, Erika Jensen-Jarolim
Journal: Journal of Allergy and Clinical Immunology (2019)
VEGFC acts as a double-edged sword in renal cell carcinoma aggressiveness
Authors: Papa Diogop Ndiaye, Maeva Dufies, Sandy Giuliano, Laetitia Douguet, Renaud Grépin, Jérôme Durivault, Philippe Lenormand, Natacha Glisse, Janita Mintcheva, Valérie Vouret-Craviari, Baharia Mograbi, Maud Wurmser, Damien Ambrosetti, Nathalie Rioux-Leclercq, Pascal Maire, Gilles Pagès
Journal: Theranostics (2019)

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not.The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. VEGFC acts as a double-edged sword in renal cell carcinoma aggressivenessPd Ndiaye, M Dufies, S
Neoadjuvant treatment in patients with locally advanced gastric cancer.
Authors: Mahmut Gumus, Serap Kaya, S Eris, Ozkan Alan, Tuba Akin Telli, Ilker Nihat Okten, Ulug Mutlu Gunaydin, Tuba Basoglu Tuylu, Seval Ay, Turkan Ozturk, Ozlem Ercelep, Bilge Aktas, Nalan Akgun Babacan, Faysal Dane, Fulden Perran Yumuk
Journal: Journal of Clinical Oncology (2019)

127 Background: Although neoadjuvant treatment has been standart approach in gastric cancer with the positive results of randomized controlled studies in recent years, neoadjuvant treatment approach rates are far below the expectations in our country. We aimed to evaluate neoadjuvant treatment approaches and results of gastric cancer patients in this retrospective study. Methods: We evaluated characteristics and survival outcomes of 54 patients that were operated after neoadjuvant systemic treatment out of 1,143 gastric cancer patients recorded in our database. Results: The median follow-up was 12 months in this study. 38% of the patients was female and the median age was 61 (24-78). While 46 % of the tumors were located in gastro-esophagial junction and cardia, others were located distally. All of the patients treated with neoadjuvant treatment had positive lymph nodes. While lymphatic and perineural invasion were detected in 67% of the patients, vascular invasion was detected in 39 % of the patients after the operation. While 43 % of the patients had grade 3 tumors, others had grade 1-2 tumors. R0 resection was achieved in 91% of the patients and D2 dissection was done in 82% of the patients. FOLFOX/XELOX, DCF/DCX, EOX/ECF and FLOT were applied as neoadjuvant treatment regimes in 19%, 50%, 21% and 11% of the patients respectively. The median chemotherapy cycle number was 3 applied pre and postoperatively. The disease control rate (response or stable disease) was achieved in 75,9 % of the patients after the neoadjuvant chemotherapy. In 13 patients progressive disease was detected and these patients were not operated. We found the median disease free survival was 25 months and overall survival was 41 months in survival analysis. Three year DFS was 29 % and 3 year OS was 52 %. Conclusions: Neoadjuvant treatment approach is important both to facilitate operation procedure and to evaluate efficacy of systemic treatment. As the survival advantage was shown in a study last year, FLOT regime is expected to be used more commonly. The patients have to be evaluated and the treatment decisions should be made in a multidisiplinary tumor board including surgeon, radiologist, medical oncologist to provide optimal treatment benefit.
Electrocardiographic Findings in Ventricular Paced Rhythm With Hyperkalemia
Authors: Rugheed Ghadban, Haytham Allaham, Mary L. Dohrmann
Journal: JAMA Internal Medicine (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Cannabidiol May Help Normalize Brain Function in Psychosis
Authors: Anita Slomski
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Biocompatible Therapeutic Catheter‐Deliverable Hydrogel for In Situ Tissue Engineering
Authors: Amanda N. Steele, Lyndsay M. Stapleton, Justin M. Farry, Haley J. Lucian, Michael J. Paulsen, Anahita Eskandari, Camille E. Hironaka, Akshara D. Thakore, Hanjay Wang, Anthony C. Yu, Doreen Chan, Eric A. Appel, Yiping Joseph Woo
Journal: Advanced Healthcare Materials (2019)

Hydrogels have emerged as a diverse class of biomaterials offering a broad range of biomedical applications. Specifically, injectable hydrogels are advantageous for minimally invasive delivery of various therapeutics and have great potential to treat a number of diseases. However, most current injectable hydrogels are limited by difficult and time-consuming fabrication techniques and are unable to be delivered through long, narrow catheters, preventing extensive clinical translation. Here, the development of an easily-scaled, catheter-injectable hydrogel utilizing a polymer-nanoparticle crosslinking mechanism is reported, which exhibits notable shear-thinning and self-healing behavior. Gelation of the hydrogel occurs immediately upon mixing the biochemically modified hyaluronic acid polymer with biodegradable nanoparticles and can be easily injected through a high-gauge syringe due to the dynamic nature of the strong, yet reversible crosslinks. Furthermore, the ability to deliver this novel hydrogel through a long, narrow, physiologically-relevant catheter affixed with a 28-G needle is highlighted, with hydrogel mechanics unchanged after delivery. Due to the composition of the gel, it is demonstrated that therapeutics can be differentially released with distinct elution profiles, allowing precise control over drug delivery. Finally, the cell-signaling and biocompatibility properties of this innovative hydrogel are demonstrated, revealing its wide range of therapeutic applications.
A multi-institutional study assessing prevalence of deleterious germline mutations in pancreatic cancer.
Authors: Meena Sadaps, Pauline Funchain, Brandie Heald, Robert Huether, Jason Pitt, Kevin White, Alok A. Khorana, Davendra Sohal
Journal: Journal of Clinical Oncology (2019)

280 Background: Pancreatic cancer is being increasingly associated with germline implications. Some large single-center studies have reported results ranging from 3.9% to 19.8% of patients found to have germline variants [Shindo, JCO 2017; Lowery, JNCI 2018]. Due to this wide range, we aim to further delineate prevalence of deleterious germline mutations in pancreatic cancer using a multi-institutional data set. We also aim to analyze predictive factors such as mutant allele frequency (MAF, in %) in germline versus somatic calls. Methods: We sequenced 23 genes in DNA prepared from clinical tissue and blood specimens submitted to Tempus Labs. Germline variants and somatic variants were processed separately. Germline variants were determined to be deleterious through the sum effect of a combination of in silico predictors, population databases, and internal evaluations. Tumor-normal comparisons were used to define somatic versus germline, and MAFs were calculated for each. Results: A total of 234 patient samples from 17 institutions were analyzed. Of these, 12 (5.1%) had predicted deleterious germline variants involving 8 different genes: BRCA1 (n = 3), CHEK2 (n = 3), ATM (n = 1), MLH1 (n = 1), MUTYH (n = 1), PALB2 (n = 1), SMAD4 (n = 1), TP53 (n = 1). For most somatic alterations, the MAFs were found to be greater than the germline deleterious alterations, with the latter approaching ~50% in most cases (Table). Conclusions: This multi-institutional study identifies 5% of patients with pancreatic cancer to have deleterious germline alterations. Somatic variant testing, particularly when paired with germline, can be used as a screening method for genetic counseling referrals, especially with MAF analyses of paired tumor-normal samples. [Table: see text]
Baseline characteristics and clinical symptoms related to respiratory viruses identified among patients presenting with influenza-like illness in primary care
Authors: C. Souty, S. Masse, M. Valette, S. Behillil, I. Bonmarin, C. Pino, C. Turbelin, L. Capai, A.M. Vilcu, B. Lina, S. van der Werf, T. Blanchon, A. Falchi, T. Hanslik
Journal: Clinical Microbiology and Infection (2019)
Abstract 16014: Gender Differences in Characteristics, Treatment and Outcomes in a Regional System of Cardiac Arrest Care
Authors: Nichole Bosson, Andrea Fang, Amy H Kaji, Joseph L Thomas, James T Niemann
Journal: Circulation (2015)

Introduction: Gender differences have been noted in outcomes from out-of-hospital cardiac arrest (OHCA) but remain poorly defined. The purpose of this study was to evaluate gender differences in OHCA characteristics, interventions, and outcomes. Methods: This is a retrospective analysis of registry data from a regionalized cardiac arrest system. Patients treated for OHCA with return of spontaneous circulation (ROSC) are transported to the nearest cardiac arrest receiving center with percutaneous coronary intervention (PCI) capability and therapeutic hypothermia protocols. Outcomes are reported to a single registry, from which all adult patients were identified from 2011 through 2014. The characteristics, treatment interventions, and outcomes were evaluated by gender and then further stratified by ECG presence of STEMI and initial rhythm. The adjusted odds ratio (OR) for survival with good neurologic outcome (defined as cerebral perfusion category (CPC) 1 or 2) was calculated for women compared to men. Results: There were 5174 OHCA in the registry, 3080 males and 2094 females. Women were older, median 71 years (inter-quartile range (IQR) 59-82) vs 66 (IQR 55-78) and, despite similar frequency of witnessed arrest, were less likely to present with a shockable rhythm (22% vs 35%, Risk Difference (RD) 13% 95%CI 11-15%) compared to men. Women were also less likely to have STEMI on the ECG (23% vs 32%, RD 13% 95%CI 7-11%) receive catheterization (11% vs 25%, RD 14% 95%CI 12-16%), PCI (5% vs 14%, RD 9% 95%CI 7-11%) or TH (33% vs 40%, RD 7% 95%CI 4-10%). Women had decreased survival to hospital discharge (33% vs 40%, RD 7% 95%CI 4-10%) and a lower proportion with good neurologic outcome (16% vs 24%, RD 8% 95%CI 6-10%). The differences persisted with stratification by STEMI or initial rhythm. However, after adjustment for age, arrest characteristics (initial rhythm, witness, bystander CPR), interventions (catheterization, PCI, and TH) and interaction between gender and treatment, female gender was not associated with decreased survival with good neurologic outcome, OR 0.9, 95%CI 0.7-1.1. Conclusion: Gender-related differences in OHCA characteristics and treatment (including PCI, catheterization, and TH) are independent predictors of outcome disparities.
A nonhuman primate model of inherited retinal disease
Authors: Ala Moshiri, Rui Chen, Soohyun Kim, R. Alan Harris, Yumei Li, Muthuswamy Raveendran, Sarah Davis, Qingnan Liang, Ori Pomerantz, Jun Wang, Laura Garzel, Ashley Cameron, Glenn Yiu, J. Timothy Stout, Yijun Huang, Christopher J. Murphy, Jeffrey Roberts, Kota N. Gopalakrishna, Kimberly Boyd, Nikolai O. Artemyev, Jeffrey Rogers, Sara M. Thomasy
Journal: Journal of Clinical Investigation (2019)

Inherited retinal degenerations are a common cause of untreatable blindness worldwide, with retinitis pigmentosa and cone dystrophy affecting approximately 1 in 3500 and 1 in 10,000 individuals, respectively. A major limitation to the development of effective therapies is the lack of availability of animal models that fully replicate the human condition. Particularly for cone disorders, rodent, canine, and feline models with no true macula have substantive limitations. By contrast, the cone-rich macula of a nonhuman primate (NHP) closely mirrors that of the human retina. Consequently, well-defined NHP models of heritable retinal diseases, particularly cone disorders that are predictive of human conditions, are necessary to more efficiently advance new therapies for patients. We have identified 4 related NHPs at the California National Primate Research Center with visual impairment and findings from clinical ophthalmic examination, advanced retinal imaging, and electrophysiology consistent with achromatopsia. Genetic sequencing confirmed a homozygous R565Q missense mutation in the catalytic domain of PDE6C, a cone-specific phototransduction enzyme associated with achromatopsia in humans. Biochemical studies demonstrate that the mutant mRNA is translated into a stable protein that displays normal cellular localization but is unable to hydrolyze cyclic GMP (cGMP). This NHP model of a cone disorder will not only serve as a therapeutic testing ground for achromatopsia gene replacement, but also for optimization of gene editing in the macula and of cone cell replacement in general.