tbuckley/cabot-search huggingface dataset:
Diagnostic aids developed for lower‐limb cellulitis
Authors: M. Patel, S.I. Lee, R.K. Akyea, D. Grindlay, N. Francis, N.J. Levell, P. Smart, J. Kai, K.S. Thomas
Journal: British Journal of Dermatology (2019)

Cellulitis is a common skin infection seen in the UK, with most cases affecting the lower limbs. However, diagnosing lower limb cellulitis can at first be challenging as there is no diagnostic checklist available in the UK. This study aimed to identify what tools or checklists have been developed to help diagnose lower limb cellulitis. The authors, based in the UK, carried out a review of existing research and found eight studies that looked at patient features, blood tests, scans and an algorithm to help diagnosis. There was variation in the types of tools used, and the quality of the studies. The present study found insufficient evidence to support any current tools or checklists that have been developed to help diagnose lower limb cellulitis. Future work should focus on speaking to patients with cellulitis and health care professionals to better understand what should be included in a diagnostic tool/checklist.
Increased Global Gene Promoter Methylation after Relapse (Rel) of Acute Promyelocytic Leukemia (APL) from All-trans Retinoic Acid (ATRA)-Containing Treatment Is Dissociated from Concurrent Gene Expression Changes.
Authors: Da-Cheng Zhou, Qingping Cui, Haesook Kim, Reid Thompson, John Greally, Eric E. Bouhassira, Robert E. Gallagher
Journal: Blood (2007)
Prognostic Impact of Anti-Apoptotic and Multidrug Resistance Phenotypes in Elderly Acute Myeloid Leukemia Patients.
Authors: María-Belén Vidriales, Lilia E. Suarez, Jose García-Laraña, Raimundo García-Boyero, María-José Moreno, Teresa Bernal, Vicencia Martín Reina, Jose D. González-San Miguel, José J. Pérez, Pascual Fernández-Abellán, Julio García-Suarez, Jesús F. San Miguel, Alberto Orfao
Journal: Blood (2005)
Economic and Health Care Burdens of Hepatitis Delta: A Study of Commercially Insured Adults in the United States
Authors: Mohamed I. Elsaid, You Li, Tina John, Navaneeth Narayanan, Carolyn Catalano, Vinod K. Rustgi
Journal: Hepatology (2019)

The paucity of data regarding the extent of hepatitis delta virus (HDV) associated health care burden in the United States is an important obstacle to assessing the cost-effectiveness of potential intervention strategies. In this study, we characterized the health care use and cost burdens of HDV in the United States using real-world claims data.We conducted a case-control study using the Truven Health MarketScan Commercial Claims databases from 2011-2014. A total of 2,727 HDV cases were matched 1:1 by sociodemographic characteristics and comorbidities to chronic hepatitis B virus (HBV) controls using propensity scores. The HDV group had significantly higher prevalence of substance abuse, sexually transmitted diseases, decompensated cirrhosis, cirrhosis, and hepatitis C virus compared to patients with chronic HBV. First HDV diagnosis was associated with significant increases in the total number of health care claims (25.61 vs. 28.99; P < 0.0001) and total annual health care costs ($19,476 vs. $23,605; P < 0.0001) compared with pre-HDV baseline. The case-control analysis similarly indicated higher total claims (28.99 vs. 25.19; P < 0.0001) and health care costs ($23,605 vs. $18,228; P < 0.0001) in HDV compared with HBV alone. Compared with HBV controls, HDV cases had an adjusted incident rate ratio of 1.16 (95% confidence interval: 1.10, 1.22) times the total number of annual claims and an adjusted incident rate ratio 1.32 (95% confidence interval 1.17, 1.48) times the total annual health care cost.HDV is associated with higher health care use and cost burden than HBV alone, underscoring the need for improved screening and treatment.
Lenalidomide Response in Relapsed/Refractory Aggressive Non-Hodgkin’s Lymphoma Is Related to Tumor Burden and Time from Rituximab Treatment.
Authors: Peter H. Wiernik, Izidore S. Lossos, Joseph M. Tuscano, Glen Justice, Julie M. Vose, Craig E. Cole, Kyle McBride, Kenton Wride, Dennis Pietronigro, Kenichi Takeshita, Annette Ervin-Haynes, Jerome B. Zeldis, Thomas M. Habermann
Journal: Blood (2007)
Особенности фармакотерапии гастроэзофагеальной рефлюксной болезни у беременных
Authors: Yu.S. Breslavets
Journal: GASTROENTEROLOGY (2019)

Статья посвящена проблеме гастроэзофагеальной рефлюксной болезни (ГЭРБ) у беременных. Освещены особенности механизма развития ГЭРБ у беременных. Проанализован ряд научных исследований разных авторов относительно безопасности лечебных мероприятий у данной категории пациенток. Автор акцентирует внимание на наличии нерешенных вопросов в фармакотерапии ГЭРБ у беременных.
APR-246 Combined with Azacitidine (AZA) in TP53 Mutated Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML). a Phase 2 Study By the Groupe Francophone Des Myélodysplasies (GFM)
Authors: Thomas Cluzeau, Marie Sebert, Ramy Rahmé, Stefania Cuzzubbo, Anouk Walter-petrich, Jacqueline Lehmann che, Pierre Peterlin, Blandine Beve, Habiba Attalah, Fatiha Chermat, Elsa Miekoutima, Odile Beyne-Rauzy, Christian Recher, Aspasia Stamatoullas, Lise Willems, Emmanuel Raffoux, Céline Berthon, Bruno Quesnel, Antoine Carpentier, David A Sallman, Sylvie Chevret, Lionel Ades, Pierre Fenaux
Journal: Blood (2019)
A Review on the State of the Art in Atrial Fibrillation Detection Enabled by Machine Learning
Authors: Ali Rizwan, Ahmed Zoha, Ismail Ben Mabrouk, Hani M. Sabbour, Ameena Saad Al-Sumaiti, Akram Alomainy, Muhammad Ali Imran, Qammer H. Abbasi
Journal: IEEE Reviews in Biomedical Engineering (2020)

Atrial Fibrillation (AF) the most commonly occurring type of cardiac arrhythmia is one of the main causes of morbidity and mortality worldwide. The timely diagnosis of AF is an equally important and challenging task because of its asymptomatic and episodic nature. In this paper, state-of-the-art ECG data-based machine learning models and signal processing techniques applied for auto diagnosis of AF are reviewed. Moreover, key biomarkers of AF on ECG and the common methods and equipment used for the collection of ECG data are discussed. Besides that, the modern wearable and implantable ECG sensing technologies used for gathering AF data are presented briefly. In the end, key challenges associated with the development of auto diagnosis solutions of AF are also highlighted. This is the first review paper of its kind that comprehensively presents a discussion on all these aspects related to AF auto-diagnosis in one place. It is observed that there is a dire need for low energy and low cost but accurate auto diagnosis solutions for the proactive management of AF.
Lysine acetyltransferase 8 is involved in cerebral development and syndromic intellectual disability
Authors: Lin Li, Mohammad Ghorbani, Monika Weisz-Hubshman, Justine Rousseau, Isabelle Thiffault, Rhonda E. Schnur, Catherine Breen, Renske Oegema, Marjan M.M. Weiss, Quinten Waisfisz, Sara Welner, Helen Kingston, Jordan A. Hills, Elles M.J. Boon, Lina Basel-Salmon, Osnat Konen, Hadassa Goldberg-Stern, Lily Bazak, Shay Tzur, Jianliang Jin, Xiuli Bi, Michael Bruccoleri, Kirsty McWalter, Megan T. Cho, Maria Scarano, G. Bradley Schaefer, Susan S. Brooks, Susan Starling Hughes, K.L.I. van Gassen, Johanna M. van Hagen, Tej K. Pandita, Pankaj B. Agrawal, Philippe M. Campeau, Xiang-Jiao Yang
Journal: Journal of Clinical Investigation (2019)

Epigenetic integrity is critical for many eukaryotic cellular processes. An important question is how different epigenetic regulators control development and influence disease. Lysine acetyltransferase 8 (KAT8) is critical for acetylation of histone H4 at lysine 16 (H4K16), an evolutionarily conserved epigenetic mark. It is unclear what roles KAT8 plays in cerebral development and human disease. Here, we report that cerebrum-specific knockout mice displayed cerebral hypoplasia in the neocortex and hippocampus, along with improper neural stem and progenitor cell (NSPC) development. Mutant cerebrocortical neuroepithelia exhibited faulty proliferation, aberrant neurogenesis, massive apoptosis, and scant H4K16 propionylation. Mutant NSPCs formed poor neurospheres, and pharmacological KAT8 inhibition abolished neurosphere formation. Moreover, we describe KAT8 variants in 9 patients with intellectual disability, seizures, autism, dysmorphisms, and other anomalies. The variants altered chromobarrel and catalytic domains of KAT8, thereby impairing nucleosomal H4K16 acetylation. Valproate was effective for treating epilepsy in at least 2 of the individuals. This study uncovers a critical role of KAT8 in cerebral and NSPC development, identifies 9 individuals with KAT8 variants, and links deficient H4K16 acylation directly to intellectual disability, epilepsy, and other developmental anomalies.
Degos' Disease With Constrictive Pericarditis:- A Case Report -
Authors: Kazushi Yukiiri, Katsufumi Mizushige, Takashi Ueda, Atsufumi Tomohiro, Kohjiro Tanimoto, Yoshie Matsuoka, Yasuo Kubota, Hirohide Matsuo
Journal: Circulation (2000)

A 47-year-old man with Degos' disease was examined by echocardiography, which showed hypokinesis of the apical left ventricular wall with pericardial effusion. To evaluate the myocardial perfusion and coronary flow reserve, 201Tl scintigraphy and intracoronary Doppler flowmetry were performed. The coronary flow reserve was not decreased nor was there angiographical coronary stenosis, although a pressure study revealed constrictive dysfunction of both ventricles. The constrictive pericarditis might have been induced by pericardial vasculitis, thereby causing the left ventricular wall motion abnormality.
肝、胰、胆系统基础知识（一）——急性胰腺炎
Authors: 黄永辉, 周丽雅
Journal: BMJ (2003)

急性胰腺炎相当常见,年发病率为1～2千万人。80％以上与酒精和胆结石有关,但这两类原因的比率存在着广泛的地区差异。在英国的大多数医疗中心,胆结石为更常见原因,与另一主要病因之比在2:1以上。
A pilot randomized controlled trial of exercise to improve cognitive performance in patients with stable glioma: a proof of concept
Authors: Karin Gehring, Martijn M Stuiver, Eva Visser, Corelien Kloek, Martin van den Bent, Monique Hanse, Cees Tijssen, Geert-Jan Rutten, Martin J B Taphoorn, Neil K Aaronson, Margriet M Sitskoorn
Journal: Neuro-Oncology (2019)

Abstract Background Patients with glioma often suffer from cognitive deficits. Physical exercise has been effective in ameliorating cognitive deficits in older adults and neurological patients. This pilot randomized controlled trial (RCT) explored the possible impact of an exercise intervention, designed to improve cognitive functioning in glioma patients, regarding cognitive test performance and patient-reported outcomes (PROs). Methods Thirty-four clinically stable patients with World Health Organization grades II/III glioma were randomized to a home-based remotely coached exercise group or an active control group. Patients exercised 3 times per week for 20–45 minutes, with moderate to vigorous intensity, during 6 months. At baseline and immediate follow-up, cognitive performance and PROs were assessed with neuropsychological tests and questionnaires, respectively. Linear regression analyses were used to estimate effect sizes of potential between-group differences in cognitive performance and PROs at 6 months. Results The exercise group (n = 21) had small- to medium-sized better follow-up scores than the control group (n = 11) on several measures of attention and information processing speed, verbal memory, and executive function, whereas the control group showed a slightly better score on a measure of sustained selective attention. The exercise group also demonstrated small- to medium-sized better outcomes on measures of self-reported cognitive symptoms, fatigue, sleep, mood, and mental health–related quality of life. Conclusions This small exploratory RCT in glioma patients provides a proof of concept with respect to improvement of cognitive functioning and PROs after aerobic exercise, and warrants larger exercise trials in brain tumor patients.
Brentuximab Vedotin in First Refractory/Relapsed Classical Hodgkin Lymphoma Patients Treated By Chemotherapy (ICE) before Autologous Transplantation. Final Analysis of Phase II Study
Authors: Aspasia Stamatoullas, Herv Ghesquieres, Lauriane Clement filliatre, Philippe Quittet, Franck Morschhauser, Vincent Ribrag, Veronique Edeline, Pauline Brice
Journal: Blood (2019)
Treatment implications for immunohistochemistry-based diagnoses with low positive predictive value.
Authors: Raji Pillai, Charles Handorf, William David Henner
Journal: Journal of Clinical Oncology (2013)

e22033 Background: In a recent study (Handorf, C. et al., Am. J. Surg. Pathol., in press), the accuracy of tumor diagnoses using immunohistochemistry (IHC) (83%) was directly compared to accuracy of gene expression profiling (GEP) (89%). However, in clinical practice, IHC is more commonly used initially and GEP is used secondarily in difficult-to-diagnose cases. For this reason, it is important to identify which IHC-based diagnoses have a low positive predictive value (PPV) and therefore might benefit from the addition of GEP or other diagnostic procedures. Methods: The direct comparison study included 157 metastatic tumors of known origin that represented 15 possible tumor types. A panel of four board-certified anatomic pathologists was blinded to the primary site and each pathologist used IHC to render final tumor diagnoses. 472 specimen reviews and diagnoses were performed. The fraction correct (PPV) for the diagnoses rendered for each of the 15 tumor types in the study were compared. Results: The PPV for each of the 15 tissue types diagnoses was either: low (gastric, 29%; pancreatic, 31%; non-small cell lung, 55%), moderate (prostate, renal, hepatocellular, ovarian and colorectal, 85-90%) or high (bladder, breast, testicular germ cell, non-Hodgkin’s lymphoma, melanoma, sarcoma and thyroid, 94-100%). Among the 90 diagnoses of tissues with low PPVs (gastric, pancreatic and non-small lung cancer) there were 59 incorrect diagnoses. For 23 of those 59 diagnoses, the actual tumor type is treatable for prolonged survival including: breast (N=11), colorectal (N=6), ovarian (N=3) and prostate (N=3) cancer. Conclusions: The PPV for IHC-based diagnoses of primary site varies substantially depending of the type of tissue diagnosed. Pathologists should consider the likely PPV of their IHC-based diagnoses of primary site when considering the use of GEP or other methods to refine their diagnosis. For many of the IHC-based primary site diagnoses with low PPVs, the correct primary site diagnosis may allow treatment for prolonged survival.
Biomarker-Driven Staging—Are We There Yet?
Authors: Siddhartha Devarakonda, Ramaswamy Govindan
Journal: JAMA Network Open (2019)

Greg J. Haro, MD; Bonnie Sheu, MD; Nancy R. Cook, ScD; Gavitt A. Woodard, MD; Michael J. Mann, MD; Johannes R. Kratz, MD
Can BCL2L12 be a promising favorable prognostic biomarker in breast cancer?
Authors: Alexandros Tzovaras, Athina Kladi, Kleita Michaelidou, Nikolaos Tsoukalas, Grecory Tsoukalas, Pantelis Kountourakis, Sofia Stamatopoulou, Georgios Oikonomopoulos, Ioannis Misitzis, Alexandros Ardavanis, Andreas Scorilas
Journal: Journal of Clinical Oncology (2013)

11117 Background: Many genes of the BCL2 family were found to be implicated in breast carcinogenesis and to serve as possible prognostic markers. BCL2-like 12 (BCL2L12) is a new member of BCL2 gene family which was discovered and cloned by members of our group and found to be expressed in the mammary gland. The aim of the study was the quantification and the evaluation of the prognostic value of BCL2L12 in breast cancer. Methods: BCL2L12 mRNA levels were determined in 140 samples (81 cancerous and 59 adjacent non-cancerous) of breast tissue using a highly sensitive quantitative real-time polymerase chain reaction (qRT-PCR) method. Relative quantification analysis was conducted using the comparative C T (2 -ddC T ) method, whereas the association between BCL2L12expression and clinopathological data, disease free survival (DFS) and overall survival (OS) were defined by statistical analysis. Results: Significant relationships between BCL2L12 expression and early TNM stages (P=0.021), absence of metastasis (P&lt;0.001), Estrogen Receptor (ER) positivity (P=0.031) and breast tumors of 2-5cm diameter (P=0.032) were observed. Moreover univariate analysis indicated that BCL2L12 expression is a significant prognostic factor of disease-free survival (DFS) and overall survival (OS), whereas multivariate analysis revealed strong association between BCL2L12 expression and DFS. Conclusions: With regard to breast cancer, patients bearing BCL2L12-positive tumors have significantly longer DFS and OS. These results denote a promising, independent favorable prognostic marker and a significant association of BCL2L12 expression with good outcome.
Detecting neurodegenerative pathology in multiple sclerosis before irreversible brain tissue loss sets in
Authors: Jeroen Van Schependom, Kaat Guldolf, Marie Béatrice D’hooghe, Guy Nagels, Miguel D’haeseleer
Journal: Translational Neurodegeneration (2019)

Multiple sclerosis (MS) is a complex chronic inflammatory and degenerative disorder of the central nervous system. Accelerated brain volume loss, or also termed atrophy, is currently emerging as a popular imaging marker of neurodegeneration in affected patients, but, unfortunately, can only be reliably interpreted at the time when irreversible tissue damage likely has already occurred. Timing of treatment decisions based on brain atrophy may therefore be viewed as suboptimal.This Narrative Review focuses on alternative techniques with the potential of detecting neurodegenerative events in the brain of subjects with MS prior to the atrophic stage. First, metabolic and molecular imaging provide the opportunity to identify early subcellular changes associated with energy dysfunction, which is an assumed core mechanism of axonal degeneration in MS. Second, cerebral hypoperfusion has been observed throughout the entire clinical spectrum of the disorder but it remains an open question whether this serves as an alternative marker of reduced metabolic activity, or exists as an independent contributing process, mediated by endothelin-1 hyperexpression. Third, both metabolic and perfusion alterations may lead to repercussions at the level of network performance and structural connectivity, respectively assessable by functional and diffusion tensor imaging. Fourth and finally, elevated body fluid levels of neurofilaments are gaining interest as a biochemical mirror of axonal damage in a wide range of neurological conditions, with early rises in patients with MS appearing to be predictive of future brain atrophy.Recent findings from the fields of advanced neuroradiology and neurochemistry provide the promising prospect of demonstrating degenerative brain pathology in patients with MS before atrophy has installed. Although the overall level of evidence on the presented topic is still preliminary, this Review may pave the way for further longitudinal and multimodal studies exploring the relationships between the abovementioned measures, possibly leading to novel insights in early disease mechanisms and therapeutic intervention strategies.
Occurrence and Resolution of Anthracycline Cardiotoxicity and Impact on Treatment Outcomes Among Children Treated on the AAML1031 Clinical Trial: A Report from the Children's Oncology Group
Authors: Kelly D Getz, Lillian Sung, Robert B. Gerbing, Todd A. Alonzo, Yimei Li, Yuan-Shung V. Huang, Kasey J Leger, Jessica A. Pollard, Todd M Cooper, Edward Anders Kolb, Alan S Gamis, Richard Aplenc
Journal: Blood (2019)
Elevated Circulating Levels of Thrombospondin-1 in Plasma Are Associated with Increased Circulating Levels of TGFb and Pro-Inflammatory Cytokines in Patients Afflicted with Rheumatoid Arthritis: Utilization of the Multiplexed Protein Profiling on Microarray by Rolling-Circle Amplification Technique.
Authors: Mario C. Rico, Joanne M. Manns, Hien Nguyen, Nicole Beharry, Meera Reddy, Audrey B. Uknis, Raul A. De La Cadena
Journal: Blood (2006)
Swim Bladder as a Novel Biomaterial for Cardiovascular Materials with Anti‐Calcification Properties
Authors: Jing Liu, Binhan Li, Huimin Jing, Yongjian Wu, Deling Kong, Xigang Leng, Zhihong Wang
Journal: Advanced Healthcare Materials (2019)

Abstract Calcification is a major cause of cardiovascular materials failure and deterioration, which leads to the restriction of their wide application. To develop new materials with anti‐calcification capability is an urgent clinical requirement. Herein, a natural material derived from swim bladders as one promising candidate is introduced, which is prepared by decellularization and glutaraldehyde (GA) crosslinking. Data show that the swim bladder is mainly composed of collagen I, glycosaminoglycan (GAG), and elastin, especially rich in elastin, in accordance with higher elastic modulus in comparison to bovine pericardium. Moreover, the calcification of this material is proved dramatically lower than that of bovine pericardium by in vitro calcification assessments and in vivo assay using a rat subcutaneous implantation model. Meanwhile, good cytocompatibility, hemocompatibility, and enzymatic stability are demonstrated by in vitro assays. Further, a small diameter vascular graft using this material is successfully developed by rolling method and in situ implantation assay using a rat abdominal artery replacement model shows great performances in the aspect of higher patency and lower calcification. Taken together, these superior properties of swim bladder‐derived material in anti‐calcification, proper mechanical strength and stability, and excellent hemocompatibility and cytocompatibility endow it a great candidate as cardiovascular biomaterials.
The Role of B Cell-Activating Factor (BAFF) in the Biology of Multiple Myeloma (MM).
Authors: Noopur Raje, Shaji Kumar, Teru Hideshima, Kenji Ishitsuka, Hiroshi Yasui, Yu-Tzu Tai, Norihiko Shiraishi, Tanyel Kizeltepe, Shweta Chhetri, Sonia Vallet, Robert L. Schlossman, Paul G. Richardson, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Blood (2005)
The Emerging Role of Cytidine Deaminase in Human Diseases: A New Opportunity for Therapy?
Authors: Audrey Frances, Pierre Cordelier
Journal: Molecular Therapy (2019)

The recycling activity of cytidine deaminase (CDA) within the pyrimidine salvage pathway is essential to DNA and RNA synthesis. As such, CDA deficiency can lead to replicative stress, notably in Bloom syndrome. Alternatively, CDA also can deaminate cytidine and deoxycytidine analog-based therapies, such as gemcitabine. Thus, CDA overexpression is often associated with lower systemic, chemotherapy-related, adverse effects but also with resistance to treatment. Considering the increasing interest of CDA in cancer chemoresistance, the aims of this review are to describe CDA structure, regulation of expression, and activity, and to report the therapeutic strategies based on CDA expression that recently emerged for tumor treatment.