tbuckley/cabot-search huggingface dataset:
BENEFICIAL EFFECT OF MULTIPOINT PACING IN CRT PATIENTS BASED ON NON-INVASIVE HEMODYNAMIC ASSESSMENT: DATA OF THE COMPACT-MPP STUDY
Authors: Antonio Curcio, Antonio Ruocco, Giuseppe Santarpia, Salvatore Crispo, Grazia Canciello, Giuseppe Ammirati, Maria Colangelo, Caterina Covello, Daniela Capasso, Antonio Rapacciuolo, Ciro Mauro, Ciro Indolfi
Journal: Journal of the American College of Cardiology (2019)
OBESITY PARADOXICALLY IMPROVES SURVIVAL IN CARDIAC RESYNCHRONIZATION THERAPY (CRT) PATIENTS INDEPENDENT OF EFFECT ON LEFT VENTRICULAR REMODELING AND CRT RESPONSE
Authors: Divyang Patel, Kevin Trulock, Saleem Toro, Nishant Shah, Anirudh Kumar, Adam Grimaldi, Laurie Ann Moennich, Haitham Ahmed, Wai Hong Tang, Eiran Gorodeski, Mark Niebauer, Bruce Wilkoff, Niraj Varma, John Rickard
Journal: Journal of the American College of Cardiology (2019)
EFFECTS OF PATISIRAN, AN RNA INTERFERENCE THERAPEUTIC, ON REGIONAL LEFT VENTRICULAR MYOCARDIAL DEFORMATION IN HEREDITARY TRANSTHYRETIN AMYLOIDOSIS: THE APOLLO STUDY
Authors: Masatoshi Minamisawa, David Adams, Arnt Kristen, Giampaolo Merlini, Michel S. Slama, Angela Dispenzieri, Rodney H. Falk, Verena Karsten, Marianne Sweetser, Jihong Chen, Richard Riese, John Vest, Scott Solomon
Journal: Journal of the American College of Cardiology (2019)
PROGNOSIS OF PATIENT WITH ACUTE HEART FAILURE ACCORDING TO ONE-YEAR CHANGES IN LEFT VENTRICULAR EJECTION FRACTION
Authors: Hyun-Jin Kim, Ju-Hee Lee, Dae In Lee, Kyung-Kuk Hwang, Myeong-Chan Cho, Hae-Young Lee, Hyun-Jai Cho, Jin Oh Choi, Eun Seok Jeon, Min-Seok Kim, Jae-Joong Kim, Sang Eun Lee, Shung Chull Chae, Sang Hong Baek, SeokMin Kang, Dong-Ju Choi, Byung-Su Yoo, Kye Hun Kim
Journal: Journal of the American College of Cardiology (2019)
LONG-TERM OUTCOMES OF ATRIAL SEPTAL STENT IMPLANTATION IN IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION
Authors: Karen Petrosian, Olga Bockeria, Manolis Pursanov, Sergey Gorbachevskiy, Andrey Sobolev, Gulamzhan Dadabaev, Leo Bockeria
Journal: Journal of the American College of Cardiology (2019)
HIGH-SENSITIVITY C-REACTIVE PROTEIN AND HYPERTENSION: COMBINED EFFECTS ON CORONARY SEVERITY AND CARDIOVASCULAR OUTCOMES
Authors: Hui-Hui Liu, Ye-Xuan Cao, Di Sun, Jing-Lu Jin, Hui-Wen Zhang, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Ying Gao, Qiu-Ting Dong, Geng Liu, Qian Dong, Jian-Jun Li
Journal: Journal of the American College of Cardiology (2019)
EPIDEMIOLOGY AND CLINICAL SIGNIFICANCE OF ATRIAL FIBRILLATION IN PATIENTS CIRRHOSIS: A META-ANALYSIS
Authors: Tarun Jacob Bathini, Ronpichai Chokesuwattanaskul, Charat Thongprayoon, Oisin A. O'Corragain, Wisit Cheungpasitporn
Journal: Journal of the American College of Cardiology (2019)
SHORT-CIRCUITING AND OVERSENSING DUE TO INSULATION BREACHES IN A DUAL CONDUCTOR IMPLANTABLE CARDIOVERTER DEFIBRILLATOR LEAD: IMPLICATIONS FOR PATIENT SAFETY AND MANAGEMENT
Authors: Moses Wananu, Jay Sengupta, Larissa Stanberry, Robert Hauser, Raed Abdelhadi
Journal: Journal of the American College of Cardiology (2019)
Unresolved issues in treatment outcome definitions for nontuberculous mycobacterial pulmonary disease
Authors: Seong Mi Moon, Byung Woo Jhun, Charles L. Daley, Won-Jung Koh
Journal: European Respiratory Journal (2019)

<b>Evaluation of treatment outcomes after 6 months may be appropriate for NTM pulmonary disease (NTM-PD) patients. Patients with a single positive culture after culture conversion should be carefully followed up to detect recurrence of NTM-PD.</b>http://ow.ly/JrSy30oj3uZ
VASCULAR ENDOTHELIAL FUNCTION AND ARTERIAL STIFFNESS IN HIV-INFECTED PATIENTS WITH AND WITHOUT ABACAVIR REGIMEN
Authors: Roumen Iordanov, Claudia Martinez, Meela Parker, Alex Gonzalez, Dalhila Solorzano, Bonni Lang, Alejandro Chedebeau, Valeria Porras, Rajiv Parmar, Orlando Gomez-Marin, Neil Schneiderman, Ivonne Schulman, Michael Kolber, Barry Hurwitz
Journal: Journal of the American College of Cardiology (2019)
CARDIORESPIRATORY FITNESS IMPROVES THE ACCURACY OF ATHEROSCLEROTIC CARDIOVASCULAR DISEASE POOLED COHORT RISK MODEL
Authors: Alexander Fardman, Gabriel D. Banschick, Razi Rabia, Shlomo Segev, Robert Klempfner, Ehud Grossman, Elad Maor
Journal: Journal of the American College of Cardiology (2019)
CLINICAL EFFICACY OF OCT-GUIDED ROTATIONAL ATHERECTOMY FOR SEVERELY CALCIFIED CORONARY LESION COMPARED TO IVUS-GUIDED ROTATIONAL ATHERECTOMY
Authors: Norihiro Kobayashi, Yoshiaki Ito, Keisuke Hirano, Masahiro Yamawaki, Motoharu Araki
Journal: Journal of the American College of Cardiology (2019)
A REAL-TIME HEMODYNAMIC ICD MEASUREMENT: EVALUATION IN CHRONICALLY IMPLANTED LARGE ANIMALS WITH CONGESTIVE HEART FAILURE
Authors: Lucas Holt, Meagan Oglesby, Andrew Wang, Sandeep Sagar, Zalmen Blanck, Sander Hacker, Gladys Escobar, Danny Escobedo, Devon Klipsic, John Pearce, Jonathan Valvano, Marc Feldman
Journal: Journal of the American College of Cardiology (2019)
IMPACT OF GASTROINTESTINAL BLEEDING ON IN-HOSPITAL OUTCOMES ON PATIENTS WITH PERCUTANEOUS MECHANICAL CIRCULATORY SUPPORT DEVICES: A NATIONWIDE PERSPECTIVE
Authors: Mohit Pahuja, Shruti Mony, Adegbola Oluwole, Harsh Mehta, Omar Chehab, Sagar Ranka, Ishani Shah, Tushar Mishra, Hossam Abubakar, Tomo Ando, Ahmed Yassin, Aman Handa, Luis Afonso
Journal: Journal of the American College of Cardiology (2019)
IMPACT OF CLINICAL PRESENTATION ON THE DETECTION OF VULNERABLE PLAQUE BY NEAR INFRARED SPECTROSCOPY: A LIPID RICH PLAQUE (LRP) STUDY SUB-ANALYSIS
Authors: Evan Shlofmitz, Paige Craig, Hector Garcia Garcia, Varinder Singh, Ziad Ali, William Skinner, Andre Artis, Tim Ten Cate, Rui Wang, Sean Madden, Priti Shah, Quan Zou, James Muller, Carlo Di Mario, Rebecca Torguson, Ron Waksman
Journal: Journal of the American College of Cardiology (2019)
Aspirin alleviates endothelial gap junction dysfunction through inhibition of NLRP3 inflammasome activation in LPS-induced vascular injury
Authors: Xing Zhou, Yanjiao Wu, Lifeng Ye, Yunting Wang, Kaimin Zhang, Lingjun Wang, Yi Huang, Lei Wang, Shaoxiang Xian, Yang Zhang, Yang Chen
Journal: Acta Pharmaceutica Sinica B (2019)

The loss of endothelial connective integrity and endothelial barrier dysfunction can lead to increased vascular injury, which is related to the activation of endothelial inflammasomes. There are evidences that low concentrations of aspirin can effectively prevent cardiovascular diseases. We hypothesized that low-dose aspirin could ameliorate endothelial injury by inhibiting the activation of NLRP3 inflammasomes and ultimately prevent cardiovascular diseases. Microvascular endothelial cells were stimulated by lipopolysaccharide (2 μg/mL) and administrated by 0.1-2 mmol/L aspirin. The wild type mice were stimulated with LPS (100 μg/kg/day), and 1 h later treated with aspirin (12.5, 62.5, or 125 mg/kg/day) and dexamethasone (0.0182 mg/kg/day) for 7 days. Plasma and heart were harvested for measurement of ELISA and immunofluorescence analyses. We found that aspirin could inhibit NLRP3 inflammasome formation and activation in vitro in dose-dependent manner and has correlation between the NLRP3 inflammasome and the ROS/TXNIP pathway. We also found that low-concentration aspirin could inhibit the formation and activation of NLRP3 inflammasome and restore the expression of the endothelial tight junction protein zonula occludens-1/2 (ZO1/2). We assume that aspirin can ameliorate the endothelial layer dysfunction by suppressing the activation of NLRP3 inflammasome.
ROLE OF INNATE AND ADAPTIVE IMMUNITY ON ATHEROSCLEROSIS IN SUBJECTS WITH FAMILIAL HYPERCHOLESTEROLEMIA
Authors: Maria Cristina Izar, Waleria Fonzar, Francisco Fonseca, Henrique Fonseca, Tuany P. Silva, Alfredo Eyer, Daniela Teixeira, Maria E.R. Coste, Carolina França, Ieda Longo-Maugéri, Antonio Carvalho, Joao B. Pesquero
Journal: Journal of the American College of Cardiology (2019)
LEFT VENTRICULAR ASSIST DEVICE OUTFLOW GRAFT COMPRESSION: INCIDENCE, CLINICAL CORRELATES, AND OUTCOMES
Authors: Cory Trankle, John Grizzard, Keyur Shah, Leila Rezai Gharai, Franklin Dana, Mohammed Quader, Matthew Kang, Andrew Andreae, Kevin Desai, Zachary Gertz
Journal: Journal of the American College of Cardiology (2019)
EFFECTS OF MACITENTAN ON RIGHT VENTRICULAR REMODELING IN PULMONARY ARTERIAL HYPERTENSION: RESULTS FROM THE REPAIR STUDY INTERIM ANALYSIS
Authors: Stephan Rosenkranz, Nazzareno Galiè, Richard Channick, Emmanuelle Cottreel, David Kiely, Nicolas Martin, Andrew Peacock, Ahmed Tawakol, Adam Torbicki, Anton Vonk Noordegraaf
Journal: Journal of the American College of Cardiology (2019)
SPONTANEOUS RUPTURED AORTIC PLAQUES ARE MORE FREQUENT: NOVEL INSIGHTS FROM ANGIOSCOPY
Authors: Sei Komatsu, Satoru Takahashi, Mitsuhiko Takewa, Tomoki Ohara, Atsushi Hirayama, Chikao Yutani, Kazuhisa Kodama
Journal: Journal of the American College of Cardiology (2019)
ANALYSIS OF TREATMENT STRATEGIES AND SHORT-TERM OUTCOMES FOR CORONARY ARTERY DISEASE IN END-STAGE RENAL DISEASE (ESRD) COMPARED TO NON-ESRD PATIENTS FOLLOWING CARDIAC CATHETERIZATION
Authors: Preetham Reddy Muskula, Hassan Alkhawam, James Ampadu, Maryna Popp, Tarek Helmy
Journal: Journal of the American College of Cardiology (2019)
MULTIPARAMETRIC INPUT FROM PET MYOCARDIAL PERFUSION IMAGING IMPROVES DETECTION OF LEFT MAIN AND 3-VESSEL CORONARY ARTERY DISEASE ANGIOGRAPHICALLY: DERIVATION OF ‘PET DIAGNOSTIC SCORE'
Authors: Firas J. Al Badarin, Poghni Peri-Okonny, Bader Madoukh, Laith Derbas, Mohamed Omer, Ashwath Kumar, Ahmed Elkaryoni, John A. Spertus, Arthur McGhie, Krishna Patel, Brett Sperry, Paul Chan, Timothy Bateman
Journal: Journal of the American College of Cardiology (2019)
Abstract 385: Characterization of Cellular Infiltrate in Bioprosthetic Aortic and Mitral Valves
Authors: Sabin J Bozso, Ratnadeep Basu, Benjamin Adams, Gavin Oudit, Darren H Freed, Jayan Nagendran, Michael C Moon, Jeevan Nagendran
Journal: Circulation Research (2018)

Background: Bioprosthetic xenogeneic valves tend to deteriorate over time, termed structural valve deterioration (SVD), leading to valvular dysfunction. Several studies have hypothesized that SVD is a result of a chronic immune-mediated rejection process; however, a paucity of data exists demonstrating this conclusively. Objectives: Demonstrate that valves explanted for SVD contain a significantly greater burden of immune cellular infiltrate compared to normal human heart valves. Methods: Adult patients undergoing bioprosthetic aortic or mitral valve explantation secondary to a diagnosis of SVD were included in this study. A control arm included valves explanted from hearts without valvular disease considered for transplantation that were not utilized. Specimens underwent immunohistochemical staining using standard techniques utilizing the following primary monoclonal antibodies: anti-CD68, anti-CD20, and anti-CD3. Results: Eighteen valves explanted for SVD were analyzed along with 4 control valves. All valves were explanted from male patients with a mean age of 62-years. Overall, 12% (n=1) of patients had diabetes mellitus, 50% (n=4) had hypertension, 12% (n=1) had renal dysfunction and 38% (n=3) were on a lipid-lowering medication. Our results demonstrate that valves developing SVD have a cellular infiltrate containing significantly more immune cells than normal human valves. Specifically, there are significantly more CD3+ T-cells (p&lt;0.05) and CD68+ macrophages (p&lt;0.05) present in the cellular infiltrate of the SVD valves compared to the normal controls. Furthermore, while the cellular infiltrate of the SVD valves contains CD20+ B-cells, plasma cells, and neutrophils, none of these cells are present on the normal control valves (all p-values &lt;0.05). Conclusions: Our data suggest a significantly greater immune cell infiltrate can be found in explanted bioprosthetic valves developing SVD than normal human valves, providing support for the chronic-immune mediated rejection hypothesis. This study will ultimately lead to a better understanding of the immune mechanisms responsible for SVD in bioprosthetic xenograft valves and will contribute to our goal of developing novel therapeutic techniques to mitigate development of SVD.
ETHNIC DIFFERENCES IN 10 YEAR CLINICAL OUTCOMES AFTER DRUG ELUTING STENTING: WHY DO AFRICAN AMERICANS FARE SO POORLY?
Authors: Stephen G. Ellis, Leslie Cho, Russell Raymond, Ravi Nair, Conrad Simpfendorfer, Murat Tuzcu, Christopher Bajzer, A. Lincoff, Samir Kapadia
Journal: Journal of the American College of Cardiology (2019)
ASSOCIATION BETWEEN LOW BASELINE TESTOSTERONE LEVELS AND ADVERSE CLINICAL OUTCOMES IN MEN WITH ESTABLISHED CARDIOVASCULAR DISEASE IN THE ATHEROTHROMBOSIS INTERVENTION IN METABOLIC SYNDROME WITH LOW HDL AND HIGH TRIGLYCERIDES AND IMPACT ON GLOBAL HEALTH OUTCOMES TRIAL
Authors: Ruth McBride, William E. Boden, Michael G. Miller, Christopher Harvey, Michael C. Snabes, Jeffrey M. Schmidt, Todd Anderson, Mark McGovern, Patrice Desvigne Nickens, Jerome Fleg, Moti Kashyap, Jeffrey Probstfield
Journal: Journal of the American College of Cardiology (2019)
TWO-YEAR RESULTS AFTER IMPLANTATION OF AN ULTRATHIN, BIORESORBABLE POLYMER SIROLIMUS-ELUTING CORONARY STENT COMPARED TO A THIN, DURABLE POLYMER EVEROLIMUS-ELUTING STENT: HEALTH ECONOMIC EVALUATION
Authors: Soeren Mattke, Mark Hanson, Anissa C. Dallmann, Marc Bentele
Journal: Journal of the American College of Cardiology (2019)
THE INCREMENTAL COST OF ACUTE KIDNEY INJURY AFTER PERCUTANEOUS CORONARY INTERVENTION: IMPLICATIONS FOR PRACTICE IN THE UNITED STATES
Authors: Christian McNeely, John A. Spertus, Jasvindar Singh, Howard Kurz, John House, Nathan Frogge, Samuel Lindner, Hemant Kulkarni, Frederick Masoudi, Amit Amin
Journal: Journal of the American College of Cardiology (2019)
CD19-CAR-T Therapy Followed By Allogeneic Hematopoietic Stem Cell Transplantation in Refractory/Relapsed and High Risk B-Cell Acute Lymphoblastic Leukemia
Authors: Yanli Zhao, Jianping Zhang, Deyan Liu, Min Xiong, Zhijie Wei, Ruijuan Sun, Jiarui Zhou, Yue Lu, Xingyu Cao, Junfang Yang, Xian Zhang, Hui Wang, Hongxing Liu, Peihua Lu, Daopei Lu
Journal: Blood (2018)
Abstract 577: Beclin1 Regulates UVRAG and Rab5-Mediated Endosomal Degradation Pathway
Authors: Mark Lampert, Rita Najor, Leonardo Leon, Asa Gustafsson
Journal: Circulation Research (2018)

Effective cellular quality control is crucial for cellular homeostasis and cardiac health. Defects in the pathways that regulate the removal of damaged proteins and organelles contribute to heart failure. Autophagy is well known for its role in removing protein aggregates and organelles; however, we recently found that the small GTPase Rab5 and early endosomes also participate in Parkin-mediated mitochondrial clearance. Beclin1 is a scaffolding protein which can form distinct PI3K protein complexes to regulate different processes. Here we have investigated the role of Beclin1 in regulating the endosomal degradation pathway in cells. Utilizing Beclin1-deficient mouse embryonic fibroblasts (MEFs), we assessed the effect of Beclin1 deficiency on endosomal activity. We found that the number of Rab5+ early endosomes were decreased, while EGF receptor levels were increased in Beclin1-/- MEFs compared to WT. This suggests that endosomal-mediated degradation is reduced in the absence of Beclin1. Moreover, the constitutively active Rab5Q79L is unable to hydrolyze bound GTP and its overexpression leads to oversized endosomes in WT cells. Interestingly, Rab5Q79L protein was unstable in Beclin1-/- MEFs and failed to induce formation of enlarged endosomes. Beclin1 has also been reported to form a complex with UVRAG, but the exact function of the Beclin1-UVRAG complex is unclear. We found that Beclin1-/- MEFs had significantly decreased UVRAG protein levels. Unexpectedly, restoration of UVRAG, but not Beclin1, restored Rab5Q79L stability in Beclin1-/- MEFs. Endogenous Rab5 levels were unaffected in Beclin1-/- MEFs after UVRAG restoration, indicating that UVRAG is required to stabilize the GTP bound active Rab5. Finally, to examine the function of Beclin1 in myocytes in vivo , we generated inducible cardiac-specific Beclin1 KO mice. Within one week of deleting Beclin1 in the adult heart, we observed significant contractile dysfunction and increased mortality. These mice also had reduced autophagic flux and significantly decreased UVRAG protein levels, but increased IGFR-beta receptor protein levels. Together, these data demonstrate the critical role of Beclin1 in cellular homeostasis as a regulator of not only autophagy but also endosomal activities.
Concussion Biomarkers
Authors: Breton M. Asken
Journal: JAMA Neurology (2019)

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IMPACT OF OBESITY ON THE OUTCOMES AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Norihiko Kamioka, Hope Caughron, John Lisko, Patricia Keegan, Jose Binongo, Jane Wei, Isida Byku, Lucia Alvarez, Shawn Reginauld, Hima Patel, Aneesha Maini, Bradley Leshnower, Chandan Devireddy, Kreton Mavromatis, James Stewart, Peter Block, Robert Guyton, Kendra Grubb, Adam B. Greenbaum, Vasilis Babaliaros
Journal: Journal of the American College of Cardiology (2019)
Abstract 264: A Complement Pathway is Responsible for Degeneration of Right Ventricular Outflow Tract
Authors: Shogo Ito, Tomohisa Seki, Shinsuke Yuasa, Jin Komuro, Toshiomi Katsuki, Mai Kimura, Yoshikazu Kishino, Dai Kusumoto, Shugo Tohyama, Yoshihiro Fukumoto, Keiichi Fukuda
Journal: Circulation Research (2018)

Backgrounds: Right ventricular outflow tract (RVOT) has a unique role in the pathogenesis of inherited cardiac diseases such as Brugada syndrome and arrhythmogenic right ventricular cardiomyopathy. However, it remains elusive how RVOT plays a role in the pathogenesis. We hypothesized that RVOT would have different character from other parts of the heart and those phenotypes would be regulated by key factors. Methods: Microarray analysis of several parts of adult murine hearts was performed and differentially expressed genes (DEGs) in RVOT were extracted. Pathway analysis was performed using Ingenuity Pathway Analysis (IPA). Potential upstream candidate genes were examined using rat cardiomyocytes in vitro and adult mouse in vivo. Results: As a result of microarray analysis for RVOT, right ventricle, left ventricle and ventricular septum, 995 genes were statistically extracted as DEG in RVOT. IPA analysis revealed that an alternative complement pathway was significantly activated in RVOT. Additionally, complement factor, C3a was shown as a potential upstream gene attributable to these features. Administration of C3a protein to cardiomyocytes resulted in activation of several MAP kinases including ERK via C3a receptor and suppression of oncostatin M signaling. Furthermore, in vivo analysis, administration of C3a receptor antagonist dramatically improved right ventricular function in mouse model of right ventricular overload, pulmonary artery constriction. There results indicated that C3a would regulate the unique phenotypes in RVOT and would be the potent effector to right ventricular heart failure. Conclusion: We revealed that an activated alternative complement pathway has a crucial role in the unique features of RVOT and the pathogenesis of right ventricular heart failure. The blockade of the pathway would be a therapeutic target of RVOT-related diseases.
COMBINATION OF EXERCISE AND CALORIES RESTRICTION EXERTS GREATER EFFICACY ON CARDIOPROTECTION THAN MONOTHERAPY IN OBESE-INSULIN RESISTANT RATS THROUGH THE IMPROVEMENT OF CARDIAC CALCIUM REGULATION
Authors: Siripong Palee, Wanitchaya Minta, Duangkamol Mantor, Wissuta Sutham, Thidarat Jaiwongkam, Sasiwan Kerdphoo, Wasana Pratchayasakul, Siriporn Chattipakorn, Nipon Chattipakorn
Journal: Journal of the American College of Cardiology (2019)
Nonproteinuric Versus Proteinuric Phenotypes in Diabetic Kidney Disease: A Propensity Score–Matched Analysis of a Nationwide, Biopsy-Based Cohort Study
Authors: Masayuki Yamanouchi, Kengo Furuichi, Junichi Hoshino, Tadashi Toyama, Akinori Hara, Miho Shimizu, Keiichi Kinowaki, Takeshi Fujii, Kenichi Ohashi, Yukio Yuzawa, Hiroshi Kitamura, Yoshiki Suzuki, Hiroshi Sato, Noriko Uesugi, Satoshi Hisano, Yoshihiko Ueda, Shinichi Nishi, Hitoshi Yokoyama, Tomoya Nishino, Kenichi Samejima, Kentaro Kohagura, Yugo Shibagaki, Koki Mise, Hirofumi Makino, Seiichi Matsuo, Yoshifumi Ubara, Takashi Wada
Journal: Diabetes Care (2019)

OBJECTIVE Clinicopathological characteristics, renal prognosis, and mortality in patients with type 2 diabetes and reduced renal function without overt proteinuria are scarce. RESEARCH DESIGN AND METHODS We retrospectively assessed 526 patients with type 2 diabetes and reduced renal function (estimated glomerular filtration rate [eGFR] &amp;lt;60 mL/min/1.73 m2), who underwent clinical renal biopsy and had follow-up data, from Japan’s nationwide multicenter renal biopsy registry. For comparative analyses, we derived one-to-two cohorts of those without proteinuria versus those with proteinuria using propensity score–matching methods addressing the imbalances of age, sex, diabetes duration, and baseline eGFR. The primary end point was progression of chronic kidney disease (CKD) defined as new-onset end-stage renal disease, decrease of eGFR by ≥50%, or doubling of serum creatinine. The secondary end point was all-cause mortality. RESULTS Eighty-two patients with nonproteinuria (urine albumin-to-creatinine ratio [UACR] &amp;lt;300 mg/g) had lower systolic blood pressure and less severe pathological lesions compared with 164 propensity score–matched patients with proteinuria (UACR ≥300 mg/g). After a median follow-up of 1.9 years (interquartile range 0.9–5.0 years) from the date of renal biopsy, the 5-year CKD progression-free survival was 86.6% (95% CI 72.5–93.8) for the nonproteinuric group and 30.3% (95% CI 22.4–38.6) for the proteinuric group (log-rank test P &amp;lt; 0.001). The lower renal risk was consistent across all subgroup analyses. The all-cause mortality was also lower in the nonproteinuric group (log-rank test P = 0.005). CONCLUSIONS Patients with nonproteinuric diabetic kidney disease had better-controlled blood pressure and fewer typical morphological changes and were at lower risk of CKD progression and all-cause mortality.
ASSOCIATION BETWEEN CARDIOLOGY VISIT AND EVIDENCE-BASED STATIN PRESCRIPTION AND STATIN ADHERENCE PATTERNS: FINDINGS FROM THE VETERANS AFFAIRS NATIONAL DATABASE
Authors: Hasan Rehman, Sarah Ahmed, Julia Akeroyd, Khurram Nasir, Mahboob Alam, Dhruv Mahtta, Salim Virani
Journal: Journal of the American College of Cardiology (2019)
PROGNOSTIC PREDICTION OF CARDIOPULMONARY EXERCISE TEST PARAMETERS IN HEART FAILURE PATIENTS WITH ATRIAL FIBRILLATION
Authors: António Amadeu Valentim Gonçalves, Tiago Pereira-da-Silva, Rui Soares, Joana Feliciano, Rita Ilhão Moreira, Rui Cruz Ferreira
Journal: Journal of the American College of Cardiology (2019)