tbuckley/cabot-search huggingface dataset:
Underdiagnosis of Primary Hyperparathyroidism—The Need for a System-Level Fix
Authors: Quan-Yang Duh, Insoo Suh, Marshall L. Stoller
Journal: JAMA Surgery (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
The safety and clinical effects of administering a multiantigen-targeted T cell therapy to patients with multiple myeloma
Authors: Premal D. Lulla, Ifigeneia Tzannou, Spyridoula Vasileiou, George Carrum, Carlos A. Ramos, Rammurti Kamble, Tao Wang, Mengfen Wu, Mrinalini Bilgi, Adrian P. Gee, Shivani Mukhi, Betty Chung, Linghua Wang, Ayumi Watanabe, Manik Kuvalekar, Mira Jeong, Yumei Li, Shamika Ketkar, Matthew French-Kim, Bambi Grilley, Malcolm K. Brenner, Helen E. Heslop, Juan F. Vera, Ann M. Leen
Journal: Science Translational Medicine (2020)

Infusions of autologous T cells specific for multiple tumor antigens were safe and induced responses in some patients with multiple myeloma.
Assessment of Bereaved Caregiver Experiences of Advance Care Planning for Children With Medical Complexity
Authors: Sarah Lord, Clara Moore, Madison Beatty, Eyal Cohen, Adam Rapoport, Jonathan Hellmann, Kathy Netten, Reshma Amin, Julia Orkin
Journal: JAMA Network Open (2020)

<h3>Importance</h3> Advance care planning (ACP) is the process of discussing values and preferences for care to help inform medical decision-making. Children with medical complexity (CMC) often have a shortened life span with an unpredictable clinical course and timing of death; however, there is a paucity of literature that describes the experience of ACP from the perspective of bereaved family caregivers of CMC. <h3>Objective</h3> To explore the experiences of bereaved family caregivers with ACP for CMC. <h3>Design, Setting, and Participants</h3> This qualitative study included 12 interviews with 13 bereaved family caregivers of CMC whose deaths had occurred in the 5 years before study commencement (2013-2018). Participants were recruited at a single tertiary care pediatric center; CMC were treated by the Complex Care or Long-term Ventilation clinic in Toronto, Ontario, Canada. Data were collected from July to October 2018. Thematic analysis with an inductive approach was used. <h3>Exposures</h3> Qualitative interviews were conducted using purposive sampling of bereaved family caregivers using semistructured interviews that were recorded and transcribed. Interviews were conducted until saturation was reached. <h3>Main Outcomes and Measures</h3> Transcripts were analyzed to create themes that characterized caregiver experiences with ACP. <h3>Results</h3> A total of 13 family caregivers were interviewed in 12 interviews, all of whom were parents (12 [92%] women, 1 [8%] man) of a deceased child (aged 7 months to 12 years). Themes were divided in the 3 following categories, which align with the Donabedian model for health service quality: (1) structure of care, (2) ACP process, and (3) end-of-life experience. Notable subthemes for this population included the importance of accounting for parental expertise in the child’s care, recurrent experiences with life-threatening events, relative shock of the timing of death, and the multiple losses that caregivers experienced. <h3>Conclusions and Relevance</h3> In this study, parental experiences revealed that there are key aspects of the structure of the child’s care, process around ACP, and end-of-life care experiences that provide important reflections on ACP that warrant future study.
Incidental Finding of an Ovarian Carcinoid on 11C-Methionine PET/CT
Authors: Daria Maccora, Carmelo Caldarella, Martina Leombroni, Valerio De Stefano, Lucia Leccisotti
Journal: Clinical Nuclear Medicine (2020)

Abstract A 68-year-old woman with a history of multiple myeloma on regular hematological follow-up and with no previous relevant gynecological diseases was found to have an incidental focal uptake by the right ovary at 11 C-methionine PET/CT (C-MET). Transvaginal ultrasound was then performed showing a 2-cm solid right ovarian mass with irregular borders and moderate vascularization at color Doppler examination. Therefore, the patient underwent bilateral salpingectomy, and the final histological results revealed a rare presentation of mature teratoma with insular carcinoid tumor arising from the right ovary.
Spectrum of Cardiac Manifestations in COVID-19
Authors: Yishay Szekely, Yael Lichter, Philippe Taieb, Ariel Banai, Aviram Hochstadt, Ilan Merdler, Amir Gal Oz, Ehud Rothschild, Guy Baruch, Yogev Peri, Yaron Arbel, Yan Topilsky
Journal: Circulation (2020)

Information on the cardiac manifestations of coronavirus disease 2019 (COVID-19) is scarce. We performed a systematic and comprehensive echocardiographic evaluation of consecutive patients hospitalized with COVID-19 infection.
CHANGE IN MRI STRUCTURAL LESIONS IN THE SACROILIAC JOINT AFTER TWO YEARS OF ETANERCEPT THERAPY IN COMPARISON TO A CONTEMPORARY CONTROL COHORT
Authors: W.P. Maksymowych, M. Dougados, R.G. Lambert, R. Landewe, A. Molto, P. Claudepierre, M. de Hooge, R. Bonin, J.F. Bukowski, H. Jones, I. Logeart, R. Pedersen, A. Szumski, B. Vlahos, D. van der Heijde
Journal: Annals of the Rheumatic Diseases (2017)
Neonatal outcome in 29 pregnant women with COVID-19: A retrospective study in Wuhan, China
Authors: Yan-Ting Wu, Jun Liu, Jing-Jing Xu, Yan-Fen Chen, Wen Yang, Yang Chen, Cheng Li, Yu Wang, Han Liu, Chen Zhang, Ling Jiang, Zhao-Xia Qian, Andrew Kawai, Ben Willem Mol, Cindy-Lee Dennis, Guo-Ping Xiong, Bi-Heng Cheng, Jing Yang, He-Feng Huang
Journal: PLoS Medicine (2020)

As of June 1, 2020, coronavirus disease 2019 (COVID-19) has caused more than 6,000,000 infected persons and 360,000 deaths globally. Previous studies revealed pregnant women with COVID-19 had similar clinical manifestations to nonpregnant women. However, little is known about the outcome of neonates born to infected women.
Bronchial Thermoplasty Induced Airway Smooth Muscle Reduction and Clinical Response in Severe Asthma. The TASMA Randomized Trial
Authors: Annika W. M. Goorsenberg, Julia N. S. d’Hooghe, Karthikan Srikanthan, Nick H. T. ten Hacken, Els J. M. Weersink, Joris J. T. H. Roelofs, Samuel V. Kemp, Elisabeth H. Bel, Pallav L. Shah, Jouke T. Annema, Peter I. Bonta, C. Caneja, J. Hartman, S. Augustijn, M. van de Pol, S. Lone-Latif, O. de Boer, T. Dirksen
Journal: American Journal of Respiratory and Critical Care Medicine (2020)

Rationale: Bronchial thermoplasty (BT) is a bronchoscopic treatment for severe asthma targeting airway smooth muscle (ASM). Observational studies have shown ASM mass reduction after BT, but appropriate control groups are lacking. Furthermore, as treatment response is variable, identifying optimal candidates for BT treatment is important.Objectives: First, to assess the effect of BT on ASM mass, and second, to identify patient characteristics that correlate with BT response.Methods: Patients with severe asthma (n = 40) were randomized to immediate (n = 20) or delayed (n = 20) BT treatment. Before randomization, clinical, functional, blood, and airway biopsy data were collected. In the delayed control group, reassessment, including biopsies, was performed after 6 months of standard clinical care, followed by BT. In both groups, post-BT data including biopsies were obtained after 6 months. ASM mass (% positive desmin or α-smooth muscle actin area in the total biopsy) was calculated with automated digital analysis software. Associations between baseline characteristics and Asthma Control Questionnaire and Asthma Quality of Life Questionnaire (AQLQ) improvement were explored.Measurements and Main Results: Median ASM mass decreased by >50% in the immediate BT group (n = 17) versus no change in the delayed control group (n = 19) (P = 0.0004). In the immediate group, Asthma Control Questionnaire scores improved with -0.79 (interquartile range [IQR], -1.61 to 0.02) compared with 0.09 (IQR, -0.25 to 1.17) in the delayed group (P = 0.006). AQLQ scores improved with 0.83 (IQR, -0.15 to 1.69) versus -0.02 (IQR, -0.77 to 0.75) (P = 0.04). Treatment response in the total group (n = 35) was positively associated with serum IgE and eosinophils but not with baseline ASM mass.Conclusions: ASM mass significantly decreases after BT when compared with a randomized non-BT-treated control group. Treatment response was associated with serum IgE and eosinophil levels but not with ASM mass.
Immunothrombotic Dysregulation in COVID-19 Pneumonia Is Associated With Respiratory Failure and Coagulopathy
Authors: Leo Nicolai, Alexander Leunig, Sophia Brambs, Rainer Kaiser, Tobias Weinberger, Michael Weigand, Maximilian Muenchhoff, Johannes C. Hellmuth, Stephan Ledderose, Heiko Schulz, Clemens Scherer, Martina Rudelius, Michael Zoller, Dominik Höchter, Oliver Keppler, Daniel Teupser, Bernhard Zwißler, Michael von Bergwelt-Baildon, Stefan Kääb, Steffen Massberg, Kami Pekayvaz, Konstantin Stark
Journal: Circulation (2020)

Severe acute respiratory syndrome corona virus 2 infection causes severe pneumonia (coronavirus disease 2019 [COVID-19]), but the mechanisms of subsequent respiratory failure and complicating renal and myocardial involvement are poorly understood. In addition, a systemic prothrombotic phenotype has been reported in patients with COVID-19.A total of 62 subjects were included in our study (n=38 patients with reverse transcriptase polymerase chain reaction-confirmed COVID-19 and n=24 non-COVID-19 controls). We performed histopathologic assessment of autopsy cases, surface marker-based phenotyping of neutrophils and platelets, and functional assays for platelet, neutrophil functions, and coagulation tests, as well.We provide evidence that organ involvement and prothrombotic features in COVID-19 are linked by immunothrombosis. We show that, in COVID-19, inflammatory microvascular thrombi are present in the lung, kidney, and heart, containing neutrophil extracellular traps associated with platelets and fibrin. Patients with COVID-19 also present with neutrophil-platelet aggregates and a distinct neutrophil and platelet activation pattern in blood, which changes with disease severity. Whereas cases of intermediate severity show an exhausted platelet and hyporeactive neutrophil phenotype, patients severely affected with COVID-19 are characterized by excessive platelet and neutrophil activation in comparison with healthy controls and non-COVID-19 pneumonia. Dysregulated immunothrombosis in severe acute respiratory syndrome corona virus 2 pneumonia is linked to both acute respiratory distress syndrome and systemic hypercoagulability.Taken together, our data point to immunothrombotic dysregulation as a key marker of disease severity in COVID-19. Further work is necessary to determine the role of immunothrombosis in COVID-19.
Correction: Modelled health benefits of a sugar-sweetened beverage tax across different socioeconomic groups in Australia: A cost-effectiveness and equity analysis
Authors: Anita Lal, Ana Maria Mantilla-Herrera, Lennert Veerman, Kathryn Backholer, Gary Sacks, Marjory Moodie, Mohammad Siahpush, Rob Carter, Anna Peeters
Journal: PLoS Medicine (2020)

[This corrects the article DOI: 10.1371/journal.pmed.1002326.].
Training of Male and Female Surgical Residents
Authors: Antonio V. Sterpetti
Journal: JAMA Surgery (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Respiratory Syncytial Virus Vaccination during Pregnancy and Effects in Infants
Authors: Shabir A. Madhi, Fernando P. Polack, Pedro A. Piedra, Flor M. Munoz, Adrian A. Trenholme, Eric A.F. Simões, Geeta K. Swamy, Sapeckshita Agrawal, Khatija Ahmed, Allison August, Abdullah H. Baqui, Anna Calvert, Janice Chen, Iksung Cho, Mark F. Cotton, Clare L. Cutland, Janet A. Englund, Amy Fix, Bernard Gonik, Laura Hammitt, Paul T. Heath, Joanne N. de Jesus, Christine E. Jones, Asma Khalil, David W. Kimberlin, Romina Libster, Conrado J. Llapur, Marilla Lucero, Gonzalo Pérez Marc, Helen S. Marshall, Masebole S. Masenya, Federico Martinón-Torres, Jennifer K. Meece, Terry M. Nolan, Ayman Osman, Kirsten P. Perrett, Joyce S. Plested, Peter C. Richmond, Matthew D. Snape, Julie H. Shakib, Vivek Shinde, Tanya Stoney, D. Nigel Thomas, Alan T. Tita, Michael W. Varner, Manu Vatish, Keith Vrbicky, Judy Wen, Khalequ Zaman, Heather J. Zar, Gregory M. Glenn, Louis F. Fries
Journal: New England Journal of Medicine (2020)

Respiratory syncytial virus (RSV) is the dominant cause of severe lower respiratory tract infection in infants, with the most severe cases concentrated among younger infants.
AB0079 ANGIOPOETIN-LIKE PROTEIN TYPE 3 AS AN INDICATOR OF RHEUMATOID INFLAMMATION AND RESORPTION OF BONE TISSUE IN RHEUMATOID ARTHRITIS
Authors: V. Aleksandrov, A. Aleksandrov
Journal: Annals of the Rheumatic Diseases (2020)

: Objectives: to study the role of type 3 angiopoietin-like protein (ANGPTL3) in the development of osteoporotic processes associated with inflammation in rheumatoid arthritis (RA). Methods: 88 patients with RA were examined (women - 100%, average age - 54.2 ± 12 years old, disease duration - 11.2 ± 8.7 years, positive for rheumatoid factor (RF-IgM) - 72.7%, positive for anti-citrullinated protein antibody (ACPA) - 67%), DAS28 activity: remission - 21.6%, minimal - 11.4%, medium - 59.1%, high - 7.9%.), functional class: 0 - 1.1%, I - 25%, II - 65.9%, III - 8%). The study was conducted on a bone X-ray densitometer LUNAR DPX (GE, USA). Most of the patients (96.6%) were residents of cities, and 67 (76.1%) people lived in the metropolis (number of inhabitants more than 1 million people). The concentration of ANGPTL3 in serum was determined by enzyme immunoassay using a commercial test system “Human Angiopoietin-like Protein 3 ELISA” (“Bio Vendor”). Results: Osteoporosis is found in 52 (59%) people. Increased ANGPTL3 values (&gt; 445 ng / ml) were determined in 80.7% of cases. A significant positive correlation was found between the level of ANGPTL3 and the age of patients (r = 0.23, p = 0.032), the functional class (r = 0.214, p = 0.046), the presence of osteoporosis (r = 0.36, p = 0.039), living in the metropolis (r = 0.214, p = 0.046) and smoking (r = 0.31, p = 0.036), as well as a negative relationship with the duration of walking per day (r = -0.314, p = 0.003) and weekly (r = - 0.319, p = 0.002) was determined. The level of ANGPTL3 correlated with the activity of RA calculated by the DAS28-CRP index (p = 0.037), but not by the DAS28-ESR index (p = 0.135). It is noteworthy that ANGPTL3 is closely related to changes in bone mineral density (BMD) in the femoral neck (BMD Total: r = -0.33, p = 0.042; BMD Troch: r = -0.36, p = 0.038; BMD Wards: r = -0.44, p = 0.009), but not in the spine (L1-L4) (p&gt; 0.05). The lack of connection of ANGPTL3 with ACPA (p = 0.128) may indicate different mechanisms of influence on systemic BMD in patients with established RA. Conclusion: ANGPTL3 can be used as an indicator of pathological processes associated with rheumatoid inflammation and the development of osteoporosis. Living in a metropolis, smoking and low physical exertion has an additional negative effect on resorptive processes in bone tissue in women with active RA. Disclosure of Interests: None declared
Wearable radio-frequency sensing of respiratory rate, respiratory volume, and heart rate
Authors: Pragya Sharma, Xiaonan Hui, Jianlin Zhou, Thomas B. Conroy, Edwin C. Kan
Journal: npj Digital Medicine (2020)

Abstract Many health diagnostic systems demand noninvasive sensing of respiratory rate, respiratory volume, and heart rate with high user comfort. Previous methods often require multiple sensors, including skin-touch electrodes, tension belts, or nearby off-the-body readers, and hence are uncomfortable or inconvenient. This paper presents an over-clothing wearable radio-frequency sensor study, conducted on 20 healthy participants (14 females) performing voluntary breathing exercises in various postures. Two prototype sensors were placed on the participants, one close to the heart and the other below the xiphoid process to couple to the motion from heart, lungs and diaphragm, by the near-field coherent sensing principle. We can achieve a satisfactory correlation of our sensor with the reference devices for the three vital signs: heart rate ( r = 0.95), respiratory rate ( r = 0.93) and respiratory volume ( r = 0.84). We also detected voluntary breath-hold periods with an accuracy of 96%. Further, the participants performed a breathing exercise by contracting abdomen inwards while holding breath, leading to paradoxical outward thorax motion under the isovolumetric condition, which was detected with an accuracy of 83%.
Increased risk of SARS-CoV-2 infection in staff working across different care homes: enhanced CoVID-19 outbreak investigations in London care Homes
Authors: Shamez N Ladhani, J. Yimmy Chow, Roshni Janarthanan, Jonathan Fok, Emma Crawley-Boevey, Amoolya Vusirikala, Elena Fernandez, Marina Sanchez Perez, Suzanne Tang, Kate Dun-Campbell, Edward Wynne-Evans, Anita Bell, Bharat Patel, Zahin Amin-Chowdhury, Felicity Aiano, Karthik Paranthaman, Thomas Ma, Maria Saavedra-Campos, Richard Myers, Joanna Ellis, Angie Lackenby, Robin Gopal, Monika Patel, Meera Chand, Kevin Brown, Susan Hopkins, CoG Consortium, Nandini Shetty, Maria Zambon, Mary E Ramsay
Journal: Journal of Infection (2020)
Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217
Authors: Jason J. Northey, Alexander S. Barrett, Irene Acerbi, Mary-Kate Hayward, Stephanie Talamantes, Ivory S. Dean, Janna K. Mouw, Suzanne M. Ponik, Jonathon N. Lakins, Po-Jui Huang, Junmin Wu, Quanming Shi, Susan Samson, Patricia J. Keely, Rita A. Mukhtar, Jan T. Liphardt, John A. Shepherd, E. Shelley Hwang, Yunn-Yi Chen, Kirk C. Hansen, Laurie E. Littlepage, Valerie M. Weaver
Journal: Journal of Clinical Investigation (2020)

Women with dense breasts have an increased lifetime risk of malignancy that has been attributed to a higher epithelial density. Quantitative proteomics, collagen analysis, and mechanical measurements in normal tissue revealed that stroma in the high-density breast contains more oriented, fibrillar collagen that is stiffer and correlates with higher epithelial cell density. microRNA (miR) profiling of breast tissue identified miR-203 as a matrix stiffness-repressed transcript that is downregulated by collagen density and reduced in the breast epithelium of women with high mammographic density. Culture studies demonstrated that ZNF217 mediates a matrix stiffness- and collagen density-induced increase in Akt activity and mammary epithelial cell proliferation. Manipulation of the epithelium in a mouse model of mammographic density supported a causal relationship between stromal stiffness, reduced miR-203, higher levels of the murine homolog Zfp217, and increased Akt activity and mammary epithelial proliferation. ZNF217 was also increased in the normal breast epithelium of women with high mammographic density, correlated positively with epithelial proliferation and density, and inversely with miR-203. The findings identify ZNF217 as a potential target toward which preexisting therapies, such as the Akt inhibitor triciribine, could be used as a chemopreventive agent to reduce cancer risk in women with high mammographic density.
2008 Charles T. Dotter Memorial Lecture—More Surprises From the Healthy Donut
Authors: Geoffrey Rubin
Journal: Circulation (2008)

In 1990, magnetic resonance imaging (MRI) techniques for imaging the cardiovascular system were ascendant, generating considerable enthusiasm throughout the imaging community. Simultaneously, computed tomography (CT) was considered to play a minimal role in cardiovascular imaging. However, the introduction of spiral CT and subsequent birth of CT angiography (CTA) in 1991 transformed the field by offering greater spatial detail, more reliable image quality, and a less complex workflow than MRI. In 1998, multidetector-row CT (MDCT) revolutionized CTA by allowing high spatial resolution imaging of large vascular territories, including “whole-body” three-dimensional angiograms in less than 20 seconds. The volumetric acquisitions of CTA allowed the analysis of the arterial wall, juxta-arterial structures, and the arterial lumen, while revealing limitations of intra-arterial angiography, the previously undisputed standard for vascular imaging. MDCT also provided key breakthroughs for improving the temporal resolution of CT, enabling cardiac and coronary CTA to be performed on widely available scanning platforms. Throughout the current decade, CT advances have followed a near exponential trajectory, and the question “Can we reliably perform coronary CTA?” has been replaced by “What impact does management based on CT findings have on patient outcomes?” In just 2 years, an unprecedented diversity in novel CT technology has emerged, including multiple x-ray sources, wide-area detectors, and energy-discriminating detectors that promise extraordinary advances in the assessment of tissue composition, fine detail visualization, tissue perfusion, functional characterization, artifact suppression, and radiation dose minimization. Together, we will explore the past, present, and future of CT in the diagnosis and characterization of cardiovascular health and disease.