tbuckley/cabot-search huggingface dataset:
Abstract 12300: Time-Dependent Changes of Local Vascular Response and Angiographic Peri-Stent Contrast Staining up to Five Years After Zotarolimus-Eluting, Sirolimus-Eluting, and Bare Metal Stent Implantation
Authors: Koji Yamaguchi, Tetsuzo Wakatsuki, Takayuki Ise, Takeshi Tobiume, Syusuke Yagi, Takashi Iwase, Hirotsugu Yamada, Takeshi Soeki, Masataka Sata
Journal: Circulation (2013)

Purpose: We have previously reported local persistent hypercoagulability six months after sirolimus-eluting stent (SES) implantation by measuring plasma prothrombin fragment F1+2 (frF1+2) levels. T...
TCT CONNECT-46 Trends and In-Hospital Outcomes of Percutaneous Coronary Intervention in Non–ST-Segment Elevation Myocardial Infarction and Prior Coronary Artery Bypass Graft
Authors: Suchith Shetty, Aaqib Malik, Wilbert Aronow, Kan Liu, Alexandros Briasoulis
Journal: Journal of the American College of Cardiology (2020)
Selection of Optimal Adjuvant Chemotherapy and Targeted Therapy for Early Breast Cancer: ASCO Guideline Update
Authors: Neelima Denduluri, Mark R. Somerfield, Mariana Chavez-MacGregor, Amy H. Comander, Zoneddy Dayao, Andrea Eisen, Rachel A. Freedman, Ragisha Gopalakrishnan, Stephanie L. Graff, Michael J. Hassett, Tari A. King, Gary H. Lyman, Gillian Rice Maupin, Raquel Nunes, Cheryl L. Perkins, Melinda L. Telli, Maureen E. Trudeau, Antonio C. Wolff, Sharon H. Giordano
Journal: Journal of Clinical Oncology (2020)

The aim of this work is to update key recommendations of the ASCO guideline adaptation of the Cancer Care Ontario guideline on the selection of optimal adjuvant chemotherapy regimens for early breast cancer and adjuvant targeted therapy for breast cancer.An Expert Panel conducted a targeted systematic literature review guided by a signals approach to identify new, potentially practice-changing data that might translate into revised guideline recommendations.The Expert Panel reviewed abstracts from the literature review and identified one article for inclusion that reported results of the phase III, open-label KATHERINE trial. In the KATHERINE trial, patients with stage I to III human epidermal growth factor receptor 2 (HER2)-positive breast cancer with residual invasive disease in the breast or axilla after completing neoadjuvant chemotherapy and HER2-targeted therapy were allocated to adjuvant trastuzumab emtansine (T-DM1; n = 743) or to trastuzumab (n = 743). Invasive disease-free survival was significantly higher in the T-DM1 group than in the trastuzumab arm (hazard ratio, 0.50; 95% CI, 0.39 to 0.64; P < .001), and risk of distant recurrence was lower in patients who received T-DM1 than in patients who received trastuzumab (hazard ratio, 0.60; 95% CI, 0.45 to 0.79). Grade 3 or higher adverse events occurred in 190 patients (25.7%) who received T-DM1 and in 111 patients (15.4%) who received trastuzumab.Patients with HER2-positive breast cancer with pathologic invasive residual disease at surgery after standard preoperative chemotherapy and HER2-targeted therapy should be offered 14 cycles of adjuvant T-DM1, unless there is disease recurrence or unmanageable toxicity. Clinicians may offer any of the available and approved formulations of trastuzumab, including trastuzumab, trastuzumab and hyaluronidase-oysk, and available biosimilars.Additional information can be found at www.asco.org/breast-cancer-guidelines.
TCT CONNECT-344 Transcatheter Mitral Valve Repair or Medical Therapy for Severe Functional Mitral Regurgitation in Women Compared With Men: The COAPT Trial
Authors: Ioanna Kosmidou, JoAnn Lindenfeld, William Abraham, Michael Rinaldi, Samir Kapadia, Vivek Rajagopal, Andreas Brieke, Jason Rogers, Bahira Shahim, Bjorn Redfors, Zixuan Zhang, Michael Mack, Gregg Stone
Journal: Journal of the American College of Cardiology (2020)
A Drug‐Free Therapeutic System for Cancer Therapy by Diselenide‐Based Polymers Themselves
Authors: Chao Wei, Bingyu Liang, Yongsheng Li, Bingkun Yan, Yan Zhou, Yingbin Liu, Meidong Lang
Journal: Advanced Healthcare Materials (2020)

The application of nanotechnology-based drug delivery systems has resulted in great progresses in cancer therapy. However, current systems ultimately depend on the action of the drug itself and almost all nanocarriers only serve as excipients without any therapeutic efficacy. Herein, a drug-free therapeutic system is put forward, in which synthetic polymers themselves naturally exhibit effective anticancer activity without the loading of additional chemotherapy drugs. Aiming at this goal, amphiphilic poly(diselenide-carbonate) copolymers (PSeSeTMC), consisting of monomethyl ether poly(ethylene glycol) and diselenide-based polycarbonates, are designed and synthesized to build spherical nanoparticles, which show effective and broad-spectrum anticancer activities against multiple cancer cell lines and high selectivity toward cancer cells. Moreover, the anticancer activities can be well controlled by tuning the selenium contents in polymers. Mechanistic investigations indicate that PSeSeTMC can selectively induce cancer cells to express excessive reactive oxygen species, thereby leading to significant cellular apoptosis. In vivo antitumor studies further demonstrate high therapeutic efficacy and low side effects on normal tissue. Overall, this work provides a novel approach for cancer therapy by utilizing carriers themselves. Considering the fabrication process is pretty simple, this diselenide-based polymeric system has great potential in clinical translation.
Machine Learning Healthcare Applications (ML-HCAs) Are No Stand-Alone Systems but Part of an Ecosystem – A Broader Ethical and Health Technology Assessment Approach is Needed
Authors: Helene Gerhards, Karsten Weber, Uta Bittner, Heiner Fangerau
Journal: The American Journal of Bioethics (2020)

This article refers to:Identifying Ethical Considerations for Machine Learning Healthcare Applications
Endogenous interferon γ protects against cholestatic liver injury in mice
Authors: Miguel E. Sewnath, Tom Van Der Poll, Cornelis J. F. Van Noorden, Fiebo J. W. Ten Kate, Dirk J. Gouma
Journal: Hepatology (2002)

Cholestatic patients suffer from high perioperative morbidity and mortality, but the pathophysiology is still unknown. Interferon γ (IFN-γ) may play a role during cholestasis. Therefore, bile duct ligation (BDL) was induced in IFN-γ α-chain receptor—deficient (IFN-γR 1 —/—) and wild-type (IFN-γR 1 +/+) mice. BDL elicited increased IFN-γ messenger RNA and protein levels in the liver. One week after BDL, IFN-γR 1 +/+ mice showed less severe jaundice and liver injury than IFN-γR 1 —/— mice, as reflected by lower bilirubin and liver enzyme levels. In accordance, livers of IFN-γR 1 +/+ mice displayed smaller areas of necrosis by two-thirds than IFN-γR 1 —/— mice on histopathologic examination ( P &lt; 0.05), whereas mitotic activity and proliferating cell nuclear antigen (PCNA) labeling index was more than twice as high in IFN-γR 1 +/+ mice ( P &lt; 0.05). Livers of IFN-γR 1 +/+ mice displayed higher rates of apoptosis as indicated by DNA fragmentation rate, the number of apoptotic bodies, and poly ADP-ribose polymerase (PARP) immunostaining. BDL was not associated with lethality in IFN-γR 1 +/+ mice; IFN-γR 1 —/— mice, however, died from 10 days onward and survival after 2 weeks was 62% (10 of 16). In conclusion, these data suggest that IFN-γ protects against liver injury during extrahepatic cholestasis by stimulation of apoptosis and subsequent proliferation of hepatocytes, leading to elegant removal of damaged hepatocytes, thus preventing necrosis and concomitant inflammatory responses. (Hepatology2002;36:1466-1477).
Differential association of air pollution exposure with neonatal and postneonatal mortality in England and Wales: A cohort study
Authors: Sarah J. Kotecha, W. John Watkins, John Lowe, Jonathan Grigg, Sailesh Kotecha
Journal: PLoS Medicine (2020)

Background Many but not all studies suggest an association between air pollution exposure and infant mortality. We sought to investigate whether pollution exposure is differentially associated with all-cause neonatal or postneonatal mortality, or specific causes of infant mortality. Methods and findings We separately investigated the associations of exposure to particulate matter with aerodynamic diameter ≤ 10 μm (PM10), nitrogen dioxide (NO2), and sulphur dioxide (SO2) with all-cause infant, neonatal, and postneonatal mortality, and with specific causes of infant deaths in 7,984,366 live births between 2001 and 2012 in England and Wales. Overall, 51.3% of the live births were male, and there were 36,485 infant deaths (25,110 neonatal deaths and 11,375 postneonatal deaths). We adjusted for the following major confounders: deprivation, birthweight, maternal age, sex, and multiple birth. Adjusted odds ratios (95% CI; p-value) for infant deaths were significantly increased for NO2, PM10, and SO2 (1.066 [1.027, 1.107; p = 0.001], 1.044 [1.007, 1.082; p = 0.017], and 1.190 [1.146, 1.235; p < 0.001], respectively) when highest and lowest pollutant quintiles were compared; however, neonatal mortality was significantly associated with SO2 (1.207 [1.154, 1.262; p < 0.001]) but not significantly associated with NO2 and PM10 (1.044 [0.998, 1.092; p = 0.059] and 1.008 [0.966, 1.052; p = 0.702], respectively). Postneonatal mortality was significantly associated with all pollutants: NO2, 1.108 (1.038, 1.182; p < 0.001); PM10, 1.117 (1.050, 1.188; p < 0.001); and SO2, 1.147 (1.076, 1.224; p < 0.001). Whilst all were similarly associated with endocrine causes of infant deaths (NO2, 2.167 [1.539, 3.052; p < 0.001]; PM10, 1.433 [1.066, 1.926; p = 0.017]; and SO2, 1.558 [1.147, 2.116; p = 0.005]), they were differentially associated with other specific causes: NO2 and PM10 were associated with an increase in infant deaths from congenital malformations of the nervous (NO2, 1.525 [1.179, 1.974; p = 0.001]; PM10, 1.457 [1.150, 1.846; p = 0.002]) and gastrointestinal systems (NO2, 1.214 [1.006, 1.466; p = 0.043]; PM10, 1.312 [1.096, 1.571; p = 0.003]), and NO2 was also associated with deaths from malformations of the respiratory system (1.306 [1.019, 1.675; p = 0.035]). In contrast, SO2 was associated with an increase in infant deaths from perinatal causes (1.214 [1.156, 1.275; p < 0.001]) and from malformations of the circulatory system (1.172 [1.011, 1.358; p = 0.035]). A limitation of this study was that we were not able to study associations of air pollution exposure and infant mortality during the different trimesters of pregnancy. In addition, we were not able to control for all confounding factors such as maternal smoking. Conclusions In this study, we found that NO2, PM10, and SO2 were differentially associated with all-cause mortality and with specific causes of infant, neonatal, and postneonatal mortality.
TCT CONNECT-295 Outcomes With Manta Device for Large-Bore Access Closure After Transcatheter Aortic Valve Replacement
Authors: Michael Megaly, Kevin Buda, Emmanouil Brilakis, Ashish Pershad, Boshra Louka, Marwan Saad, Hesham Abdelaziz, Mahesh Anantha Narayanan, Mubbasher Syed, Amgad Mentias, Jessica Titus, Santiago Garcia
Journal: Journal of the American College of Cardiology (2020)
Influence of patient sex on the effectiveness of sacral neuromodulation: A cohort study from China
Authors: Lingfeng Meng, Zijian Tian, Wei Zhang, Yaoguang Zhang, Jianye Wang, Limin Liao, Qing Ling, Peng Zhang, Zhongqing Wei, Tie Zhong, Zhihui Xu, Wei Wen, Jiayi Li, Deyi Luo
Journal: International Journal of Surgery (2020)
Interaction of the Joining Region in Junctophilin-2 With the L-Type Ca <sup>2+</sup> Channel Is Pivotal for Cardiac Dyad Assembly and Intracellular Ca <sup>2+</sup> Dynamics
Authors: Polina Gross, Jaslyn Johnson, Carlos M. Romero, Deborah M. Eaton, Claire Poulet, Jose Sanchez-Alonso, Carla Lucarelli, Jean Ross, Andrew A. Gibb, Joanne F. Garbincius, Jonathan Lambert, Erdem Varol, Yijun Yang, Markus Wallner, Eric A. Feldsott, Hajime Kubo, Remus M. Berretta, Daohai Yu, Victor Rizzo, John Elrod, Abdelkarim Sabri, Julia Gorelik, Xiongwen Chen, Steven R. Houser
Journal: Circulation Research (2020)

Rationale: Ca 2+ -induced Ca 2+ release (CICR) in normal hearts requires close approximation of L-type calcium channels (LTCCs) within the transverse tubules (T-tubules) and RyR (ryanodine receptors) within the junctional sarcoplasmic reticulum. CICR is disrupted in cardiac hypertrophy and heart failure, which is associated with loss of T-tubules and disruption of cardiac dyads. In these conditions, LTCCs are redistributed from the T-tubules to disrupt CICR. The molecular mechanism responsible for LTCCs recruitment to and from the T-tubules is not well known. JPH (junctophilin) 2 enables close association between T-tubules and the junctional sarcoplasmic reticulum to ensure efficient CICR. JPH2 has a so-called joining region that is located near domains that interact with T-tubular plasma membrane, where LTCCs are housed. The idea that this joining region directly interacts with LTCCs and contributes to LTCC recruitment to T-tubules is unknown. Objective: To determine if the joining region in JPH2 recruits LTCCs to T-tubules through direct molecular interaction in cardiomyocytes to enable efficient CICR. Methods and Results: Modified abundance of JPH2 and redistribution of LTCC were studied in left ventricular hypertrophy in vivo and in cultured adult feline and rat ventricular myocytes. Protein-protein interaction studies showed that the joining region in JPH2 interacts with LTCC-α1C subunit and causes LTCCs distribution to the dyads, where they colocalize with RyRs. A JPH2 with induced mutations in the joining region (mut PG1 JPH2) caused T-tubule remodeling and dyad loss, showing that an interaction between LTCC and JPH2 is crucial for T-tubule stabilization. mut PG1 JPH2 caused asynchronous Ca 2+ -release with impaired excitation-contraction coupling after β-adrenergic stimulation. The disturbed Ca 2+ regulation in mut PG1 JPH2 overexpressing myocytes caused calcium/calmodulin-dependent kinase II activation and altered myocyte bioenergetics. Conclusions: The interaction between LTCC and the joining region in JPH2 facilitates dyad assembly and maintains normal CICR in cardiomyocytes.
TCT CONNECT-4 Surgical EXPLANTation After Transcatheter Aortic Valve Replacement Failure: Midterm Outcomes From the EXPLANT-TAVR International Registry
Authors: Gilbert Tang, Aditya Sengupta, Syed Zaid, Keti Vitanova, Ruediger Lange, Andrea Munsterer, Stephanie Simon, Shinichi Fukuhara, G. Deeb, Jessica Oakley, Pierre Voisine, Siamak Mohammadi, Dimitri Kalavrouziotis, Daniel Doyle, Josep Rodés-Cabau, Eric Dumont, Alberto Alperi, Moritz von Ballmoos, Michael Reardon, Marvin Atkins, Neal Kleiman, Michael Chu, Rodrigo Bagur, Muhanad Algadheeb, Nimesh Desai, Joseph Bavaria, Elizabeth Walsh, Lenard Conradi, Oliver Bhadra, Christian Schults, Lowell Satler, Ron Waksman, Basel Ramlawi, Martin Andreas, Paul Werner, Thomas Modine, Lionel Leroux, Brian Whisenant, John Doty, Newell Robinson, Lin Wang, George Petrossian, Joshua Goldberg, David Spielvogel, Hasan Ahmad, Giuseppe Bruschi, Kashish Goel, Ashish S. Shah, Arnar Geirsson, John Forrest, Kendra Grubb, Sameer Hirji, Pinak Shah, Guido Gelpi, Maral Ouzounian, Marc Ruel, Talal Al-Atassi, Jörg Kempfert, Axel Unbehaun, Svetlana Sonnabend, Walid Ben Ali, Philippe Demers, Reda Ibrahim, Andrea Garatti, Tom Nguyen, Alejandro Pizano, Marco Di Eusanio, Filippo Capestro, Rodrigo Estevez-Loureiro, Michael Salinger, Joshua Rovin, Susan Fisher, Augusto D'Onofrio, Antonio Divirgilio, Francesco Maisano, Maurizio Taramasso, Marco Gennari, Andrea Colli, Paolo Denti, Tsuyoshi Kaneko, Vinayak Bapat
Journal: Journal of the American College of Cardiology (2020)
Machine learning for suicidology: A practical review of exploratory and hypothesis-driven approaches
Authors: Christopher R. Cox, Emma H. Moscardini, Alex S. Cohen, Raymond P. Tucker
Journal: Clinical Psychology Review (2020)

Machine learning is being used to discover models to predict the progression from suicidal ideation to action in clinical populations. While quantifiable improvements in prediction accuracy have been achieved over theory-driven efforts, models discovered through machine learning continue to fall short of clinical relevance. Thus, the value of machine learning for reaching this objective is hotly contested. We agree that machine learning, treated as a "black box" approach antithetical to theory-building, will not discover clinically relevant models of suicide. However, such models may be developed through deliberate synthesis of data- and theory-driven approaches. By providing an accessible overview of essential concepts and common methods, we highlight how generalizable models and scientific insight may be obtained by incorporating prior knowledge and expectations to machine learning research, drawing examples from suicidology. We then discuss challenges investigators will face when using machine learning to discover models of low prevalence outcomes, such as suicide.
Clinicians use courses and conversations to change practice, not journal articles: is it time for journals to peer-review courses to stay relevant?
Authors: Rod Whiteley, Christopher Napier, Nicol van Dyk, Christian J Barton, Tim Mitchell, Darren Beales, Vasileios Korakakis
Journal: British Journal of Sports Medicine (2020)

Academic publishing is rolling in profits1 but universities and governments are fighting back against access fees adding to threats to the business that include Plan S and Sci-Hub. Clinical scientific journals were the practitioner’s link to research findings with peer review providing quality assurance. The rise of predatory journals makes it even harder for busy clinicians to sift and appraise the ever-increasing sea of available evidence in these journals.

In an effort to uncover what actually influences practice in 2020 we surveyed over 2000 sports and musculoskeletal physiotherapists on the source of the most recent change in their clinical practice. Specifically, we asked the simple question: ‘Think about the most recent aspect of your clinical practice that you changed. How did you learn about this?’ Scientific publications are not commonly used as primary sources of information to make changes to clinical practice—about 90% of respondents cited other sources (figure 1). The largest categories of responses were ‘interactions with colleagues’ and ‘attending private education short courses’ which comprised about half of all responses (the interested reader is invited to investigate these findings further …
TCT CONNECT-164 Intravascular Lithotripsy in Calcified Coronary Lesions: A Real-World Observational, European Multicenter Study
Authors: Amir Aziz, Sandeep Basavarajaiah, Gurbir Bhatia, Anirban Choudhury, Ahmed Hailan, Subramanya Upadhyaya, Leong Lee, Luca Testa, Bernardo Cortese
Journal: Journal of the American College of Cardiology (2020)
Geographic Variation in Process and Outcomes of Care for Patients With Acute Myocardial Infarction in China From 2001 to 2015
Authors: Qi Zhong, Yan Gao, Xin Zheng, Jiyan Chen, Frederick A. Masoudi, Yuan Lu, Yingqing Feng, Shuang Hu, Qiuli Zhang, Cheng Huang, Yun Wang, Harlan M. Krumholz, Xi Li, Yingling Zhou
Journal: JAMA Network Open (2020)

<h3>Importance</h3> Variations across regions for managing acute myocardial infarction (AMI) in China are little understood. <h3>Objective</h3> To evaluate geographic variation and its change with time in treatment process and outcomes for patients with AMI. <h3>Design, Setting, and Participants</h3> This cross-sectional study used data from the Patient-Centered Evaluative Assessment of Cardiac Events–Retrospective AMI project in 2001, 2006, 2011, and 2015 in 153 randomly selected hospitals across China. Patients were hospitalized for AMI. Data were analyzed from October 1 to October 31, 2019. <h3>Exposures</h3> Hospitalization in 3 geographic regions (Eastern, Central, and Western) stratified according to China's official definition. <h3>Main Outcomes and Measures</h3> Process of care measures included reperfusion therapies, aspirin, clopidogrel, β-blockers, angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, and statins. Therapy use was analyzed among patients who were clinically eligible without contraindications (considered as ideal candidates for treatments). Outcome measures included in-hospital mortality and 5-day mortality. Mixed models were used to assess the regional disparities and time-region interactions in those measures, adjusting for patient characteristics. <h3>Results</h3> In 153 hospitals across China, 27 046 patient hospitalizations for AMI were sampled. There was a significant difference across regions in process of care and the odds ratio (OR) of delivering any 1 of the 6 treatments to an ideal patient was 0.83 (95% CI, 0.76-0.91;<i>P</i> &lt; .001) for the lowest region compared with the highest region. The variation between the 2 higher regions narrowed (time-by-Eastern region interaction: OR, 0.83; 95% CI, 0.76-0.91;<i>P</i> &lt; .001). The region with the highest in-hospital mortality had 1.46 times greater in-hospital mortality (95% CI, 1.07-2.00;<i>P</i> &lt; .001) than the lowest region and the region with the highest 5-day mortality had 1.52 times greater 5-day mortality (95% CI, 1.09-2.11;<i>P</i> = .04) than the lowest region. The geographic variation in mortality did not change over time. <h3>Conclusions and Relevance</h3> In this study, significant geographic variations in process of care and outcomes were found to persist in China; further targeted and region-based approaches to AMI management are warranted.
TCT CONNECT-122 The Relationship Between Hospital Joint Commission Comprehensive Stroke Center Certification (CSCC) and Stroke Reporting in the National TVT Registry: The Michigan TAVR (MI TAVR) Collaborative Experience
Authors: Paul Grossman, Devraj Sukul, Milan Seth, Francis Shannon, Stanley Chetcuti, G. Michael Deeb
Journal: Journal of the American College of Cardiology (2020)
ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices: Summary Article
Authors: Gabriel Gregoratos, Jonathan Abrams, Andrew E. Epstein, Roger A. Freedman, David L. Hayes, Mark A. Hlatky, Richard E. Kerber, Gerald V. Naccarelli, Mark H. Schoenfeld, Michael J. Silka, Stephen L. Winters, Raymond J. Gibbons, Elliott M. Antman, Joseph S. Alpert, Gabriel Gregoratos, Loren F. Hiratzka, David P. Faxon, Alice K. Jacobs, Valentin Fuster, Sidney C. Smith
Journal: Circulation (2002)
Additional Concerns Regarding Children With Coronavirus Disease 2019
Authors: Petra Zimmermann, Florian Goetzinger, Nicole Ritz
Journal: JAMA Pediatrics (2020)

Riccardo Castagnoli, MD; Martina Votto, MD; Amelia Licari, MD; Ilaria Brambilla, MD, PhD; Raffaele Bruno, MD; Stefano Perlini, MD; Francesca Rovida, PhD; Fausto Baldanti, MD; Gian Luigi Marseglia, MD