tbuckley/cabot-search huggingface dataset:
Incidence and Localization of Vascular Events in a Well Characterized Cohort of 477 Patients with Myeloproliferative Neoplasms
Authors: Aurélie Chauveau, Damien Luque Paz, Ronan Le Calloch, Caroline Buors, Lydie Lecucq, Dominique Mottier, Valérie Ugo, Jean-Christophe Ianotto
Journal: Blood (2014)
The Impact of Center Experience on Results of Reduced Intensity – Allogeneic Hematopoietic Stem Cell Transplantation. A Survey From the Acute Leukemia Working Party (ALWP) of the European Group for Blood and Marrow Transplantation (EBMT)
Authors: Sebastian Giebel, Myriam Labopin, Mohamad Mohty, Didier Blaise, Charles Craddock, Arnon Nagler, Francesco Frassoni, Maria Sadus-Wojciechowska, Vanderson Rocha
Journal: Blood (2010)
Effectiveness of Lenalidomide in Patients with Mantle Cell Lymphoma Who Relapsed/Progressed after or Were Refractory/Intolerant to Ibrutinib: The MCL-004 Study
Authors: Michael Wang, Peter Martin, Tycel Phillips, Andre Goy, Izidore S Lossos, Simon A. Rule, Mehdi Hamadani, Nilanjan Ghosh, Craig B. Reeder, Evelyn Barnett, Marie-Laure Casadebaig Bravo, Stephen J. Schuster
Journal: Blood (2016)
Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to Chemotherapy by Abrogating the TopBP1/ATR-Mediated DNA Damage Response
Authors: Li Ding, Vijay S. Madamsetty, Spencer Kiers, Olga Alekhina, Andrey Ugolkov, John Dube, Yu Zhang, Jin-San Zhang, Enfeng Wang, Shamit K. Dutta, Daniel M. Schmitt, Francis J. Giles, Alan P. Kozikowski, Andrew P. Mazar, Debabrata Mukhopadhyay, Daniel D. Billadeau
Journal: Clinical Cancer Research (2019)

Abstract Purpose: Pancreatic ductal adenocarcinoma (PDAC) is a predominantly fatal common malignancy with inadequate treatment options. Glycogen synthase kinase 3β (GSK-3β) is an emerging target in human malignancies including PDAC. Experimental Design: Pancreatic cancer cell lines and patient-derived xenografts were treated with a novel GSK-3 inhibitor 9-ING-41 alone or in combination with chemotherapy. Activation of the DNA damage response pathway and S-phase arrest induced by gemcitabine were assessed in pancreatic tumor cells with pharmacologic inhibition or siRNA depletion of GSK-3 kinases by immunoblotting, flow cytometry, and immunofluorescence. Results: 9-ING-41 treatment significantly increased pancreatic tumor cell killing when combined with chemotherapy. Inhibition of GSK-3 by 9-ING-41 prevented gemcitabine-induced S-phase arrest suggesting an impact on the ATR-mediated DNA damage response. Both 9-ING-41 and siRNA depletion of GSK-3 kinases impaired the activation of ATR leading to the phosphorylation and activation of Chk1. Mechanistically, depletion or knockdown of GSK-3 kinases resulted in the degradation of the ATR-interacting protein TopBP1, thus limiting the activation of ATR in response to single-strand DNA damage. Conclusions: These data identify a previously unknown role for GSK-3 kinases in the regulation of the TopBP1/ATR/Chk1 DNA damage response pathway. The data also support the inclusion of patients with PDAC in clinical studies of 9-ING-41 alone and in combination with gemcitabine.
Feasibility of Population Scale Comprehensive Identification and Analysis of Complex Structural Variations in Cancer Genome Using Nanochannel Array
Authors: Alex Hastie, Ernest Lam, Heng Dai, Warren Andrews, Andy Pang, Thomas Anantharaman, Michael Saghbini, Henry Sadoski, Michael Austin, Todd Dickinson, Xing Yang, Zeljko Dzakula, Michael R. Rossi, Pui Kwok, Xun Xu, Han Cao
Journal: Blood (2014)
The B-Cell Receptor Is Required for Optimal Viability, Growth, and Chemotherapy Resistance of Diffuse Large B-Cell Lymphoma Cell Lines of the Germinal Center B-Cell Subtype
Authors: Ondrej Havranek, Stefan Koehrer, Justin M Comer, Zhiqiang Wang, Jingda Xu, Dipanjan Ghosh, Nicholas Shinners, Luhong Sun, Wencai Ma, Jan A Burger, R Eric Davis
Journal: Blood (2014)
Surface IgM Levels Independently Influence Clinical Behavior and Associate with Altered Phenotype and Genetics in Chronic Lymphocytic Leukemia
Authors: Samantha J Drennan, Annalisa D'Avola, Ian Tracy, Isla Henderson, Marta Larrayoz, Carina Mundy, Andrew S. Duncombe, Andrew J. Davies, Davide Rossi, Fiona M Ross, Laura Chiecchio, Kathleen N. Potter, Jonathan Strefford, Andrew J Steele, Peter W Johnson, Graham Packham, Freda K Stevenson, Francesco Forconi
Journal: Blood (2014)
Treatment of AML Relapse After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) Using Low-Dose Azacitidine (AZA).
Authors: Alexandre Chiattone, Rima M Saliba, Borje S. Andersson, Sergio Giralt, Manish R Sharma, Gabriela Rondon, Partow Kebriaei, Chitra Hosing, Uday Popat, Simrit Parmar, Gheath Alatrash, Qaiser Bashir, Julianne J Chen, Carrie Hai-Lai Yuen, Viviane C. Chiattone, Richard E. Champlin, Marcos De Lima
Journal: Blood (2010)
Elevated Risk of Peripheral Artery Occlusive Disease (PAOD) in Nilotinib Treated Chronic Phase Chronic Myeloid Leukemia (CML) Patients Assessed by Ankle-Brachial-Index (ABI) and Duplex Ultrasonography
Authors: Michaela Schwarz, Theo D. Kim, Tristan Mirault, Peggy Grille, Delphine Rea, Ruhdja Lindhorst, Herve Dombret, Ivo Buschmann, Wilhelm Haverkamp, Bernd Doerken, Philipp le Coutre
Journal: Blood (2012)
Thalidomide and Dexamethasone as Salvage Therapy after First Relapse in Multiple Myeloma: Analysis of Long-Term Outcomes.
Authors: Elena Zamagni, Alessandro Petrucci, Patrizia Tosi, Paola Tacchetti, Lucia Pantani, Annamaria Brioli, Maria Caterina Pallotti, Giulia Perrone, Michele Baccarani, Michele Cavo
Journal: Blood (2009)
Recombinant Human Interleukin-7 (CYT107) Enhances CD4 and CD8 T Cell Recovery Following T-Cell Depleted Allogeneic Hematopoietic Stem Cell Transplant In Patients with Myeloid Malignancies
Authors: Miguel-Angel Perales, Jenna D. Goldberg, Leuren Lechner, Jianda Yuan, Esperanza Papadopoulos, James W. Young, Ann A. Jakubowski, Guenther Koehne, Humilidad Gallardo, Ryan Kendle, Cailian Liu, Teresa Rasalan, Yinyan Xu, Bushra Zaidi, Jedd D Wolchok, Therese Croughs, Michel Morre, Molly Maloy, Glenn Heller, Marcel R.M. van den Brink
Journal: Blood (2010)
Primary lumbar paraganglioma: A single-centre UK experience over 21 years
Authors: Francesco Fiorini, José Pedro Lavrador, Francesco Vergani, Ranjeev Bhangoo, Richard Gullan, Keyoumars Ashkan
Journal: Neuro-Oncology (2019)

Abstract Objectives Paragangliomas are rare neuro-endocrine neoplasms which may occur at multiple anatomical sites, typically the adrenal glands. In the CNS, they can affect the head and neck, and more rarely the lumbar region. Primary lumbar paragangliomas are prominently vascularised lesions which can present variably and pose both diagnostic and surgical challenges. Methods We identified and analysed all cases of lumbar paraganglioma confirmed both surgically and histologically, treated at our regional neurosurgical centre. We collected retrospective clinical, radiological, surgical and histological data. Results We treated 25 patients with confirmed paraganglioma between 1997–2018. This included 19 primary tumours, of which 13 cases of primary lumbar paraganglioma (8 males (61.5%); mean age 51.3 years, range 33.2 – 68.9). Patients presented most frequently with a recent worsening of long-standing lower back pain and sciatica. 7 patients were admitted as emergency cases, including 3 with cauda equina syndrome. The average Ki67 mitotic index was 5.7% (range 1 – 10%). Conclusion We present one of the largest case series of primary lumbar paragangliomas to date to the best of our knowledge. Defining these clinical, radiological, surgical and histological features may be of assistance in recognising and managing this surgical disease.
Dynamic Noninvasive Genomic Monitoring for Outcome Prediction in Diffuse Large B-Cell Lymphoma
Authors: David M. Kurtz, Florian Scherer, Aaron M. Newman, Alexander F. Lovejoy, Daniel M. Klass, Jacob J. Chabon, Sanjiv Gambhir, Maximilian Diehn, Ash A. Alizadeh
Journal: Blood (2015)
Notch Signaling Pathway in Hematopoietic Stem Cells Is Activated through Interactive Communication with Mesenchymal Stem Cells.
Authors: Yuji Kikuchi, Akihiro Kume, Masashi Urabe, Hiroaki Mizukami, Takahiro Suzuki, Katsutoshi Ozaki, Tadashi Nagai, Keiya Ozawa
Journal: Blood (2007)
hnRNP K Overexpression Drives AML Progression By Altering Pathways Critical for Myeloid Proliferation and Differentiation
Authors: Marisa J Hornbaker, Miguel Gallardo, Xiaorui Zhang, Huaxian Ma, Peter Hu, Joseph D Khoury, Steven M. Kornblau, Carlos E Bueso-Ramos, Sean M. Post
Journal: Blood (2016)
Abstract 12306: Left and Right Ventricular Systolic and Diastolic Functional Reserves are Impaired in Anthracycline-Treated Long-Term Survivors of Childhood Cancers
Authors: Vivian Wing-yi Li, Anthony P Liu, Wilfred H Wong, Karin K Ho, Jeffrey P Yau, Daniel K Cheuk, Yiu-fai Cheung
Journal: Circulation (2017)

Background: Little is known about cardiac functional reserves in childhood cancer survivors. We assessed the left (LV) and right ventricular (RV) functional reserve in anthracycline-treated long-te...
A Novel Synthetic Chemokine Containing D-Amino Acids That Binds to the CXCR4 Receptor and Inhibits HIV-1 Infection.
Authors: Ziwei Huang, Dongxiang Liu, Navid Madani, Santosh Kumar, Won-Tak Choi, Rong Cao, Ying Li, Yigui Gao, Changzhi Dong, Jun Wang, Jing An, Joseph G. Sodroski
Journal: Blood (2004)
Chronic Myelomonocytic Leukemia Is Associated with More Frequent and More Rapid Progression to Acute Myeloid Leukemia and Shorter Survival Than Myelodysplastic Syndrome, but Is Less Frequently Treated: Analysis of Surveillance Epidemiology and End Results Data Linked to Medicare Enrollment Claims
Authors: Dan Zandberg, Ting-Ying Huang, Xuehua Ke, Maria R. Baer, Steven D. Gore, Sheila Weiss Smith, Amy J. Davidoff
Journal: Blood (2011)
Hemochromatosis in Italy in the Last 30 Years. Role of Genetic and Acquired Factors.
Authors: Anna Ludovica Fracanzani, Alberto Piperno, Luca Valenti, Mirella Fraquelli, Sabina Coletti, Alessandra Maraschi, Dario Consonni, Enzo Coviello, Dario Conte, Silvia Fargion
Journal: Blood (2009)
Engraftment of NOD/SCIDγcnull Mice with Multilineage Neoplastic Cells from Patients with Juvenile Myelomonocytic Leukemia.
Authors: Tomoko Yamamoto, Yoichi Nakamura, Masafumi Ito, Yinyan Xu, Hiroshi Yagasaki, Yoshiro Kamachi, Kazuko Kudo, Seiji Kojima
Journal: Blood (2004)
Development of a new mouse model for coxsackievirus-induced myocarditis by attenuating coxsackievirus B3 virulence in the pancreas
Authors: Sandra Pinkert, Markian Pryshliak, Kathleen Pappritz, Klaus Knoch, Ahmet Hazini, Babette Dieringer, Katrin Schaar, Fengquan Dong, Luisa Hinze, Jie Lin, Dirk Lassner, Robert Klopfleisch, Michele Solimena, Carsten Tschöpe, Ziya Kaya, Muhammad El-Shafeey, Antje Beling, Jens Kurreck, Sophie Van Linthout, Karin Klingel, Henry Fechner
Journal: Cardiovascular Research (2019)

The coxsackievirus B3 (CVB3) mouse myocarditis model is the standard model for investigation of virus-induced myocarditis but the pancreas, rather than the heart, is the most susceptible organ in mouse. The aim of this study was to develop a CVB3 mouse myocarditis model in which animals develop myocarditis while attenuating viral infection of the pancreas and the development of severe pancreatitis.We developed the recombinant CVB3 variant H3N-375TS by inserting target sites (TS) of miR-375, which is specifically expressed in the pancreas, into the 3'UTR of the genome of the pancreo- and cardiotropic CVB3 variant H3. In vitro evaluation showed that H3N-375TS was suppressed in pancreatic miR-375-expressing EndoC-βH1 cells >5 log10, whereas its replication was not suppressed in isolated primary embryonic mouse cardiomyocytes. In vivo, intraperitoneal (i.p.) administration of H3N-375TS to NMRI mice did not result in pancreatic or cardiac infection. In contrast, intravenous (i.v.) administration of H3N-375TS to NMRI and Balb/C mice resulted in myocardial infection and acute and chronic myocarditis, whereas the virus was not detected in the pancreas and the pancreatic tissue was not damaged. Acute myocarditis was characterized by myocardial injury, inflammation with mononuclear cells, induction of proinflammatory cytokines, and detection of replicating H3N-375TS in the heart. Mice with chronic myocarditis showed myocardial fibrosis and persistence of H3N-375TS genomic RNA but no replicating virus in the heart. Moreover, H3N-375TS infected mice showed distinctly less suffering compared with mice that developed pancreatitis and myocarditis after i.p. or i.v application of control virus.In this study, we demonstrate that by use of the miR-375-sensitive CVB3 variant H3N-375TS, CVB3 myocarditis can be established without the animals developing severe systemic infection and pancreatitis. As the H3N-375TS myocarditis model depends on pancreas-attenuated H3N-375TS, it can easily be used in different mouse strains and for various applications.
Outcomes of Chronic Myeloid Leukemia (CML) Patients Who Stopped Second Generation Tyrosine Kinase Inhibitors (2GTKIs) As Second Line Treatment. Results of the CML Spanish National Registry (RELMC)
Authors: J Valentin Garcia-Gutierrez, Begoña Maestro, Luis Felipe Casado, Manuel Perez-Encinas, Isabel Massague, Raquel de Paz, Santiago Osorio, Joaquin Martinez, Guiomar Bautista, Pilar Giraldo, Carmen Burgaleta, Maria Jesús Peñarrubia, Maria José Requena, Carmen Calle, Jose Ángel Hernández-Rivas, Pilar Cano, Juan Luis Steegmann
Journal: Blood (2012)
Dendritic Cell Type 2 Counts on Day 28 in HLA-Matched Related Allogeneic PBSCT Predicts the Incidence of Acute and Chronic GVHD.
Authors: Reena M. Rajasekar, Vikram Mathews, Kavitha M. Lakshmi, Auro Viswabandya, Biju George, Mammen Chandy, Alok Srivastava
Journal: Blood (2006)
Relationship Between Granulocyte JAK2 (V617F) Mutant Allele Burden and Risk of Progression to Myelofibrosis in Polycythemia Vera: a Prospective Study of 338 Patients.
Authors: Francesco Passamonti, Elisa Rumi, Daniela Pietra, Chiara Elena, Emanuela Boveri, Luca Arcaini, Cesare Astori, Sabrina Boggi, Cristiana Pascutto, Mario Lazzarino, Mario Cazzola
Journal: Blood (2009)
Autophagy Collaborates with Ubiquitination to Down-Regulate Oncoprotein E2A/Pbx1 in B Cell Acute Lymphoblastic Leukemia
Authors: Suping Zhang, Lin Song, Na Yuan, Weiwei Lin, Yan Cao, Fei Xu, Yixuan Fang, Zheng Wang, Xin Li, Zhijian Wang, Jinyang Cai, Wenli Zhao, Shaoyan Hu, Suning Chen, Xinliang Mao, Jianrong Wang
Journal: Blood (2014)
Multicenter Phase 1b Dose-Escalation Study of Ibrutinib and Lenalidomide Combined with Dose-Adjusted EPOCH-R in Patients with Relapsed/Refractory DLBCL
Authors: Wyndham H. Wilson, Leslie L. Popplewell, Tycel Phillips, Amy S. Kimball, Saurabh Chhabra, Jerry Ping, Jutta Neuenburg, Nora Cavazos, Louis M Staudt, Sven de Vos
Journal: Blood (2015)
Boost of Immune Responses Against NY-ESO-1 Following Local Radiation Therapy in Patients with Multiple Myeloma: A Potential Contribution to Tumor Immunosurveillance
Authors: Miriam Alb, Jörg Tamihardja, Erdwine Klinker, Martin Schreder, Stefan Knop, Hermann Einsele, Thomas Hünig, Andreas Rosenwald, Michael Flentje, Stephan Mielke
Journal: Blood (2016)
Identification of Patients At High Risk for Recurrent Venous Thromboembolism by Whole Blood Gene Expression Analysis
Authors: Thomas L. Ortel, Michele Beckman, W Craig Hooper, Deborah A Lewis, Jen-Tsan A. Chi, Kristy M. Kenney, Christine De Staercke, John A. Heit, Stephan Moll, Claire S. Philipp, Marilyn J. Manco-Johnson
Journal: Blood (2011)
Reports of Lactic Acidosis Attributed to Metformin, 2015–2018
Authors: James H. Flory, Sean Hennessy, Clifford J. Bailey, Silvio E. Inzucchi
Journal: Diabetes Care (2019)

OBJECTIVE In 2016, the U.S. Food and Drug Administration (FDA) revised metformin’s label to permit use in patients with mild-moderate chronic kidney disease. We sought to determine whether this change was associated with increased reports of metformin-associated lactic acidosis (MALA) to the FDA’s Adverse Event Reporting System (FAERS). RESEARCH DESIGN AND METHODS Publicly available FAERS reports were analyzed. RESULTS MALA reports increased from 521 in 2015 to 1,939 in 2018. After restriction to U.S. reports, absolute and relative increase in MALA reports was less, from 111 to 243. The proportionate reporting ratio (PRR), a measure adjusted for rates of other adverse event reports, was stable. CONCLUSIONS The increased reports deserve attention, but the PRR’s stability and FAERS’s known limitations, including lack of a denominator or control group, do not permit the conclusion that U.S. MALA rates have increased. Further study with more robust data sources is needed.
New Tests to Assess Lung Function
Authors: Peter T. Macklem, J. Milic-Emili
Journal: New England Journal of Medicine (1975)

ALTHOUGH a good number of lung-function tests are now performed routinely in most hospitals, the clinical assessment of abnormalities in the regulation of respiration is in general limited to measurements of arterial carbon dioxide and oxygen tension. The last fyears however, have seen an explosion of interest in regulation of breathing, with a welcome clinical orientation to the subject. Indeed, clinically applicable, simple and rapid methods for measuring the ventilatory response to carbon dioxide and hypoxia have recently been described.Measurement of Ventilatory Response to Carbon Dioxide by RebreathingIn 1966, Read1 developed a rebreathing technic for measuring the ventilatory . . .
Integrating HCV testing with HIV programs improves hepatitis C outcomes in people who inject drugs: A cluster-randomized trial
Authors: Sunil Suhas Solomon, Thomas C. Quinn, Suniti Solomon, Allison M. McFall, Aylur K. Srikrishnan, Vinita Verma, Muniratnam S. Kumar, Oliver Laeyendecker, David D. Celentano, Syed H. Iqbal, Santhanam Anand, Canjeevaram K. Vasudevan, Shanmugam Saravanan, David L. Thomas, Kuldeep Singh Sachdeva, Gregory M. Lucas, Shruti H. Mehta
Journal: Journal of Hepatology (2019)
FLT3-ITD Internal Tandem Duplication Confers Poor Prognosis In Patients With Acute Promyelocytic Leukemia Treated With The AIDA Protocols. Long-Term Follow-Up Analysis
Authors: Massimo Breccia, Giuseppina Loglisci, Maria Giovanna Loglisci, Roberto Ricci, Daniela Diverio, Roberto Latagliata, Robin Foà, Francesco Lo Coco
Journal: Blood (2013)
Adolescents and Young Adults (AYA) with Acute Myeloid Leukemia (AML) Have Increased Treatment-Related Mortality with Similar Outcomes -- a Report from the Children's Oncology Group Trials AAML03P1 and AAML0531
Authors: Keith J. August, Richard Aplenc, Lillian Sung, Susana C. Raimondi, Betsy A. Hirsch, John T. Horan, Todd A. Alonzo, Robert B. Gerbing, Yi-Cheng Jim Wang, Samir Kahwash, Amy Heerema-McKenney, Soheil Meshinchi, Alan S. Gamis
Journal: Blood (2014)
Antitumor effect of immune checkpoint inhibitor for subsequent therapy
Authors: Shigeru Tanaka, Masaru Kondou, Norihiro Takahara, Eiichi Maruyama, Shuuhei Hayashi, Nobuaki Mukouyama, Hidehito Tanaka, Shouei You, Shin Yamada, Satoshi Katsuno, Yuuta Kashiwagi, Masataka Tamura, Gyo Asai
Journal: Annals of Oncology (2019)
CYP3A-Mediated Drug Interaction Profile of Bruton Tyrosine Kinase Inhibitor, Acalabrutinib
Authors: Raquel Izumi, Paul G. Pearson, Ahmed Hamdy, Sara Rodriquez, Yolanda Y.L. Yang, Roger G. Ulrich, Terry Podoll, Marilee Andrew, Cecile M. Krejsa, Tim Ingallinera, J. Greg Slatter
Journal: Blood (2017)
Predictive Factors of Severe Sepsis and Septic Shock in Patients with Hematological Malignancies and Pseudomonas Infections.
Authors: Ramzi Jeddi, Hèla Ghédira, Ramzi ben Amor, Lamia Aissaoui, Karima Kacem, Walid Bouterâa, Yosr ben Abdennebi, Raihane ben Lakhal, Amel Turki, Hèla ben Abid, Zaher Belhadjali, Balkis Meddeb
Journal: Blood (2009)
Adhesion Of Acute Myeloid Leukemia Blasts To E-Selectin In The Vascular Niche Enhances Their Survival By Mechanisms Such As Wnt Activation
Authors: Sylvia Chien, Siraj U. Haq, Matthew Pawlus, Randall T. Moon, Elihu H. Estey, Frederick R. Appelbaum, Megan Othus, John L. Magnani, Pamela S. Becker
Journal: Blood (2013)
2-O, 3-O-Desulfated Heparin (ODSH) Mitigates Chemotherapy-Induced Thrombocytopenia (CIT) by Blocking the Negative Paracrine Effect of Platelet Factor 4 (PF4) On Megakaryopoiesis
Authors: Michele Lambert, Samriddhi S Sharma, Liqing Xiao, Stephen Marcus, Mortimer Poncz
Journal: Blood (2012)
Myeloid Derived Suppressor Cell Mediated AMPK Activation Regulates Multiple Myeloma Cell Survival
Authors: Kim De Veirman, Jo A. Van Ginderachter, Ivan Van Riet, Nathan De Beule, Susanne Lub, Eline Menu, Elke De Bruyne, Karin Vanderkerken, Els Van Valckenborgh
Journal: Blood (2014)
Co-Morbidity Score at the Time of Transplant Determines Prognosis in Older Patients Who Develop Acute Graft-Vs.-Host Disease (GVHD).
Authors: Amin M Alousi, Gabriela Rondon, Grace-Julia Okoroji, Uday Popat, Leandro De Padua Silva, Sharon Hymes, Joyce Neumann, Nicole M Brunelle, Partow Kebriaei, Chitra Hosing, Issa F Khouri, Elizabeth J Shpall, Muzaffar H Qazilbash, Sergio Giralt, Richard Champlin, Rima M Saliba
Journal: Blood (2009)
Low serum IgA and airway injury in World Trade Center-exposed firefighters: a 17-year longitudinal study
Authors: Barbara Putman, Lies Lahousse, Rachel Zeig-Owens, Ankura Singh, Charles B Hall, Yang Liu, Theresa Schwartz, David Goldfarb, Mayris P Webber, David J Prezant, Michael D Weiden
Journal: Thorax (2019)

Serum IgA ≤70 mg/dL (low IgA) is associated with exacerbations of chronic obstructive pulmonary disease. The association of low IgA with longitudinal lung function is poorly defined. This study included 917 World Trade Center (WTC)-exposed firefighters with longitudinal spirometry measured between September 2001 and September 2018 and IgA measured between October 2001 and March 2002. Low IgA, compared with IgA >70 mg/dL, was associated with lower forced expiratory volume in 1 s (FEV1) % predicted in the year following 11 September 2001 (94.1% vs 98.6%, p<0.001), increased risk of FEV1/FVC <0.70 (HR 3.8, 95% CI 1.6 to 8.8) and increased antibiotic treatment (22.5/100 vs 11.6/100 person-years, p=0.002). Following WTC exposure, early IgA ≤70 mg/dL was associated with worse lung function and increased antibiotic treatment.
Efficient Delivery of Antiapoptotic Signals from Marrow Stromal Cells to Acute Lymphoblastic Leukemia Cells Is Associated with Differential Expression of Genes Related to the Membrane and to Regulation of Apoptosis and Is Dependent in Part on Gap Junction Function
Authors: Craig A. Mullen, Sana Usmani, Leti Nunez, Olena Tkachenko
Journal: Blood (2016)
Flow Cytometric Response Monitoring in MDS with Del(5q) Using a Simple 5-Parameter-Score - an Elnet Imds-Flow Experience
Authors: Uta Oelschlaegel, Theresia M. Westers, Brigitte Mohr, Ulrika Johansson, Dolores Subira, Gerhard Ehninger, Martin Bornhäuser, Arjan A van de Loosdrecht, Uwe Platzbecker
Journal: Blood (2016)
NUP98-HOXA9 drives High-Risk Myeloid Disease in Zebrafish – An In Vivo platform to Study Interacting Genes and Perform Drug Discovery,
Authors: A. Michael Forrester, Andrew J Coombs, Eileen R McBride, Ian Chute, Daniel Leger, Stephen Lewis, Clemens Grabher, Thomas Look, Jason N Berman
Journal: Blood (2011)
Radioimmunotherapy for Myeloablation Before SCT in Paediatric Patients with Malignant and Non-Malignant Diseases.
Authors: Ansgar S. Schulz, Susanne Gatz, Catharina Schuetz, Norbert Blumstein, Gerhard Glatting, Thomas Kull, Sven Reske, Klaus-Michael Debatin, Wilhelm Friedrich
Journal: Blood (2007)
TP53 Positively Regulates Cell Death through TRAILR2 (DR5) but Negatively through TRAILR1 (DR4) In Myeloma Cells
Authors: Sylvanie Surget, Patricia Gomez-Bougie, David Chiron, Robin Humphreys, Philippe Moreau, Steven Le Gouill, Jean-Luc Harousseau, Regis Bataille, Martine Amiot, Catherine Pellat-Deceunynck
Journal: Blood (2010)
Targeting The Protective Microenvironment In Multiple Myeloma (MM): An Analysis Of The CXCL12/CXCR4-Axis and Its Inhibitors AMD3100 and Nox-A12 Combined With Antimyeloma Substances, Such As Pomalidomide and Carfilzomib
Authors: Anna Simon, Dagmar Wider, Marie Follo, Johannes Waldschmidt, Martina Kleber, Ralph Waesch, Monika Engelhardt
Journal: Blood (2013)