tbuckley/cabot-search huggingface dataset:
AB1285-HPR ACCELEROMETRIC ASSESSMENT OF PHYSICAL PERFORMANCE DURING THE SIT-TO-STAND TEST IN PATIENTS WITH KNEE OSTEOARTHRITIS
Authors: S. Fellous, H. Rkain, S. Afilal, J. Moulay Berkchi, T. Fatima Zahrae, A. Ilham, T. Latifa, S. Aboudrar, T. Dakka, L. Errguig, A. Jniene, M. Bakkali, F. Allali
Journal: Annals of the Rheumatic Diseases (2020)

Background: Knee osteoarthritis is a major public health issue that causes chronic pain and functional limitation. Objectives: This study aims to evaluate physical performance in knee osteoarthritis by clinical tests and accelerometer measurements, and investigate the relationship between physical perfomance alteration and clinical parameters. Methods: This is a cross-sectional study, included 40 patients with knee osteoarthritis (100% female, average age 57.6 ± 5.2 years, median evolution time was 36 [24, 69] months, overweight in 82.5% of patients). Clinical evaluation performed with the visual analog scale (VAS), Western Ontario and McMaster Osteoarthritis Index (WOMAC), Lequesne score, Get up and Go (GUG) and Timed up and Go (TUG) tests. The percentage of fat mass was measured using impedencemetry. All subjects were instructed to perform sit-to-stand transfers during 30 secondes. We measured the speed, strength and muscular power of the lower limbs during this test using the Myotest PRO® accelerometer. A correlation analysis was performed in search of factors associated with physical performance alteration. Results: The median speed during the sit-to-stand test was 4.3 [3.1-6.2] cm / sec. The median muscular strength and power during this test were 15.2 [13.6-17.7] Nm / kg and 14.5 [9.9-21.7] W / kg respectively. Body mass index (BMI) correlated negatively with the 3 parameters of physivcal performance mesured by the Myotest PRO® accelerometer (speed, strength and muscle power) during the sit-to-stand test (p&lt;0,05). There was no correlation between those measured parameters of physical performance, pain and functional indices of knee osteoarthritis. Conclusion: Our pilot study assessed the physical performance of the lower limbs in knee osteoarthritis patients, by measuring the speed, strength and muscle power during the the sit-to-stand test. It suggests an association between obesity and physical performance alteration in knee osteoarthritis patients. Disclosure of Interests: None declared
Violence against women in the covid-19 pandemic: we need upstream approaches to break the intergenerational cycle
Authors: Tessa J Roseboom
Journal: BMJ (2020)

The increased levels of violence reported during this pandemic are alarming.1 Not only because of the lasting consequences for the physical and mental health of the women and (unborn) children affected, but also because of the risk of intergenerational transmission.

The environment in which a person develops, from the very earliest stages of life, has a fundamental influence on their growth and development and …
The Influence of Immune Heterogeneity on the Effectiveness of Immune Checkpoint Inhibitors in Multifocal Hepatocellular Carcinomas
Authors: Manling Huang, Minghui He, Yu Guo, Heping Li, Shunli Shen, Yubin Xie, Xiaoxing Li, Han Xiao, Lujing Fang, Dongming Li, Baogang Peng, Lijian Liang, Jun Yu, Ming Kuang, Lixia Xu, Sui Peng
Journal: Clinical Cancer Research (2020)

Abstract Purpose: Immune checkpoint inhibitor therapy is emerging as the promising option for patients with advanced hepatocellular carcinoma. We aimed to investigate the heterogeneity of different tumor nodules of the same patient with multifocal hepatocellular carcinomas in response to immunotherapy and its molecular mechanisms. Experimental Design: We attained 45 surgical tumor samples including 33 small and 12 large nodules from 12 patients with multifocal hepatocellular carcinoma and evaluated genomic and immune heterogeneity among tumors through whole-genome sequencing and RNA sequencing. IHC was performed to validate the expression of immune markers. The responses to anti–programmed cell death protein-1 (PD-1) therapy in patients with multifocal hepatocellular carcinoma were evaluated. Results: The small and large tumors within the same patient presented with similar genomic characteristics, indicating their same genomic origin. We further found the small tumors had higher immune cell infiltration including more CD8+ T cells, M1 macrophages, and monocytes as compared with large tumors. Besides, the expression of interferon signature predictive of response to anti–PD-1 therapy was significantly upregulated in the small tumors. Moreover, the immune pathways were more vigorous along with less active proliferation pathways in the small tumors. In keeping with this, we found that small nodules were more sensitive to anti–PD-1 therapy than large nodules in patients with multifocal hepatocellular carcinoma. Conclusions: The small tumors in patients with multifocal hepatocellular carcinoma had higher immune cell infiltration and upregulation of immune pathways as compared with the large tumors, which can partially explain the different responses of small and large tumors in the same case to anti–PD-1 therapy.
Single-cell transcriptomic analysis of allergen-specific T cells in allergy and asthma
Authors: Grégory Seumois, Ciro Ramírez-Suástegui, Benjamin J. Schmiedel, Shu Liang, Bjoern Peters, Alessandro Sette, Pandurangan Vijayanand
Journal: Science Immunology (2020)

Single-cell transcriptomic analysis of allergen-specific T cells in allergy and asthma reveals new T cell subsets.
Therapeutic Resevoirs: Implantable Therapeutic Reservoir Systems for Diverse Clinical Applications in Large Animal Models (Adv. Healthcare Mater. 11/2020)
Authors: Garry P. Duffy, Scott T. Robinson, Raymond O'Connor, Robert Wylie, Ciaran Mauerhofer, Gabriella Bellavia, Stefania Straino, Francesca Cianfarani, Keegan Mendez, Rachel Beatty, Ruth Levey, Janice O'Sullivan, Liam McDonough, Helena Kelly, Ellen T. Roche, Eimear B. Dolan
Journal: Advanced Healthcare Materials (2020)

In article number 2000305 by Ellen T. Roche, Eimear B. Dolan, and co-workers, a new regenerative reservoir platform (Regenervoir) is described for use in large animal models that are easily translated to human studies, with relevance to cardiac, abdominal, and soft tissue pathologies. Regenervoir incorporates multiple novel design features essential for clinical translation, with a focus on scalability, mechanism of delivery, fixation, and filling/refilling with a therapeutic cargo.
Does bronchoscopy help the diagnosis in COVID-19 infection?
Authors: Josuel Ora, Ermanno Puxeddu, Francesco Cavalli, Federica Maria Giorgino, Andrea Girolami, Marcello Chiocchi, Giaunluigi Sergiacomi, Massimo Federici, Paola Rogliani
Journal: European Respiratory Journal (2020)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent responsible for the recent coronavirus disease 2019 (COVID-19) pandemic. The virus is predominantly spread through large droplets. The clinical features of COVID-19 are varied, ranging from asymptomatic to acute respiratory distress syndrome and multi-organ dysfunction [1]. This study evaluates the real value of using bronchoscopy to exclude the diagnosis of COVID-19 in patients with multiple negative nasal/oropharyngeal swabs <https://bit.ly/2zmSgE8>
Millimeter-thick xenoislet-laden fibers as retrievable transplants mitigate foreign body reactions for long-term glycemic control in diabetic mice
Authors: Takaichi Watanabe, Teru Okitsu, Fumisato Ozawa, Shogo Nagata, Hitomi Matsunari, Hiroshi Nagashima, Masaki Nagaya, Hiroki Teramae, Shoji Takeuchi
Journal: Biomaterials (2020)
AB1359-HPR PERCEPTION ABOUT FIBROMYALGIA AND ITS ACCOMPANYING SYMPTOMS AMONG MEXICAN PHYSICIANS
Authors: R. I. Arvizu-Rivera, N. Escobedo-Zuñiga, I. J. Colunga-Pedraza, G. Serna-Peña, A. Cárdenas
Journal: Annals of the Rheumatic Diseases (2020)

Background: Previous studies showed that 93% of rheumatologists consider fibromyalgia (FM) as a clinical entity. However, accompanying symptoms such as fatigue, widespread pain, sleep disturbance and headache are underrecognized among physicians. According to a previous study, most recognized symptoms by general practitioners are fatigue and widespread pain (72.6%), while about thirty percent of physicians recognize sleep disturbance and depression as symptoms. Objectives: To investigate physicians’ point of view of FM accompanying symptoms in northeastern Mexico. Methods: We designed an electronic survey about physicians’ perceived importance of depression, fatigue, widespread pain, sleep disturbances, headache and irritable bowel disease symptoms (pain and cramping) in patients with FM. Questions were answered using a 5-point Likert scale: 1, strongly disagree; 2, disagree; 3, neutral; 4, agree; 5, strongly agree. General practitioners, rheumatologists, neurologists, psychiatrists were included. Results: A total of 236 physicians were included: general practitioners, 149 (59.3%); rheumatologists, 21 (8.9%); neurologists 18 (7.6%); psychiatrists 8 (3.4%), and family physicians, 49 (20.8%). FM was considered a clinical diagnosis by 208 (88.1%) and most physicians think FM is both a physical and psychological condition, 190 (80.5%). Full results on physicians’ perceptions is shown in Table 1. Fatigue was the symptom which most physicians agreed or strongly agreed was important in FM, 219 (92.7%). Disagreement (any degree) was greater regarding abdominal pain/cramping being an important symptom in FM, 52 (22%). Complete results can be seen in Image 1. Table 1. Perceptions’ of physicians about FM. Variable FM is a clinic diagnostic, n (%) 208 (88.1) Unsure FM is a clinical diagnostic, n (%) 12 (5) FM is a physical illness, n (%) 33 (14) FM is a psychological illness, n (%) 11 (4.7) FM is both physical and psychological, n (%) 190 (80.5) FM has a negative impact on quality of life, n (%) 227 (96.2) FM has a negative impact on life expectancy, n (%) 135 (57.2) Conclusion: FM was considered a clinical diagnostic and an illness both physical and psychological by most physicians. Headache and abdominal pain/cramping are symptoms less likely to be perceived as important in patients with FM. References: [1]Perrot S, Choy E, Petersel D, et al. Survey of physician experiences and perceptions about the diagnosis and treatment of fibromyalgia. BMC Health Serv Res. 2012 Oct 10;12:356. [2]Kianmehr N, Haghighi A, Bidari A. Are general practitioners well informed about fibromyalgia? Int J Rheum Dis. 2017 Dec;20(12):1917-1921 Figure 1. Image 1. Perception of accompanying symptoms of fibromyalgia (FM) Disclosure of Interests: None declared
Clinical characteristics and outcomes of patients with COVID-19 and rheumatic disease in China ‘hot spot’ versus in US ‘hot spot’: similarities and differences
Authors: Jun Zhao, Rongrong Pang, Jian Wu, Yanju Guo, Yang Yang, Libo Zhang, Xinyi Xia
Journal: Annals of the Rheumatic Diseases (2020)

Clinical characteristics and outcomes of patients with COVID-19 and rheumatic disease in China 'hot spot' versus in US 'hot spot': similarities and differencesWe read with great interest the article by D'Silva et al concerning clinical characteristics and outcomes of patients with COVID-19 and rheumatic disease. 1 In this study, the authors mentioned that patients with and without rheumatic disease had similar symptoms and laboratory findings, but those with rheumatic disease were more likely to require mechanical ventilation.We analysed our data of 3059 patients with confirmed COVID-19, including 29 cases in combination with rheumatic diseases from Huoshenshan Hospital in Wuhan, which was a 'hot spot' of COVID-19 in China, from 4 February 2020 to 9 April 2020.There were 15 rheumatoid arthritis, 5 systematic lupus erythematosus, 1 Rhupus, 2 myasthenia gravis, 1 Sjögren's syndrome, 1 ankylosing spondylitis, 1 dermatomyositis, 1 autoimmune liver disease and 2 undifferentiated connective tissue disease cases (figure 1).The study population encompassed 4 men and 25 women, with median age of 61 years.Twenty-one patients presented with cough, 21 patients had fatigue, 3 had diarrhoea, 14 had varying degrees of difficulty in breathing and fever was observed in all cases.Along with the results reported by D'Silva et al, the main manifestations and laboratory findings (figure 2) in patients with rheumatic disease were similar to patients with COVID-19 in the general population.Nevertheless, the need for mechanical ventilation was much lower in our study (2/29 vs 7/52).We hypothesised that part of the differences cross studies could be explained by medication and therapeutic strategy of the rheumatic population.First, we note that the proportion of rheumatic diseases (0.95%) in our hospital was relative lower than reported by D'Silva (2.2%).And the most common comorbidity in patients with rheumatic disease was diabetes (6/29) in our study, whereas hypertension (34/52) was the most common in D'Silva's report.It is indeed that different ethnicity, different regional prevalence
Phospholipid membrane-decorated deep-penetrated nanocatalase relieve tumor hypoxia to enhance chemo-photodynamic therapy
Authors: Junjing Yin, Haiqiang Cao, Hong Wang, Kaoxiang Sun, Yaping Li, Zhiwen Zhang
Journal: Acta Pharmaceutica Sinica B (2020)

Hypoxia is a serious impediment to current treatments of many malignant tumors. Catalase, an antioxidant enzyme, is capable of decomposing endogenous hydrogen peroxide (H2O2) into oxygen for tumor reoxygenation, but suffered from in vivo instability and limited delivery to deep interior hypoxic regions in tumor. Herein, a deep-penetrated nanocatalase-loading DiIC18 (5, DiD) and soravtansine (Cat@PDS) were provided by coating catalase nanoparticles with PEGylated phospholipids membrane, stimulating the structure and function of erythrocytes to relieve tumor hypoxia for enhanced chemo-photodynamic therapy. After intravenous administration, Cat@PDS preferentially accumulated at tumor sites, flexibly penetrated into the interior regions of tumor mass and remarkably relieved the hypoxic status in tumor. Notably, the Cat@PDS + laser treatment produced striking inhibition of tumor growth and resulted in a 97.2% suppression of lung metastasis. Thus, the phospholipids membrane-coated nanocatalase system represents an encouraging nanoplatform to relieve tumor hypoxia and synergize the chemo-photodynamic cancer therapy.
Abstract IA02: The Treehouse Childhood Cancer Initiative
Authors: David Haussler
Journal: Clinical Cancer Research (2020)

Abstract Each year over 4,000 children with cancer in the US lack adequate treatment options for their disease, underscoring the urgent need for new therapeutic targets and new therapies. Cancer genomic investigations focusing on the identification of recurrent DNA changes in tumors that could be targeted by therapies have been disappointing in the majority of pediatric cancers, as these diseases have lower rates of somatic mutation compared to adult cancers. To address this challenge, the UC Santa Cruz Genomics Institute launched the Treehouse Childhood Cancer Initiative, an innovative program that identifies novel therapeutic targets for difficult-to-treat pediatric cancers through leveraging the power of large, shared tumor RNA-sequencing datasets. Treehouse partners with pediatric cancer hospitals, including Lucille Packard Children’s Hospital at Stanford, UCSF Benioff Children’s Hospital, Children’s Hospital of Orange County, Nationwide Children’s Hospital, and British Columbia Children’s Hospital, to investigate whether the comparative RNA-seq approach is feasible and useful when applied to patients prospectively. A preliminary analysis of 126 patients from four hospitals showed that comparative RNA-seq analysis can identify druggable targets for over 74.3% of difficult-to-treat pediatric cancer patients, while state-of-the-art DNA analysis finds potential therapeutic options for only 45.9% of patients. Current work focuses on determining the clinical utility of the Treehouse approach. Citation Format: David Haussler. The Treehouse Childhood Cancer Initiative [abstract]. In: Proceedings of the AACR Special Conference on Advancing Precision Medicine Drug Development: Incorporation of Real-World Data and Other Novel Strategies; Jan 9-12, 2020; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2020;26(12_Suppl_1):Abstract nr IA02.
Clinical characteristics of COVID-19 in 104 people with SARS-CoV-2 infection on the Diamond Princess cruise ship: a retrospective analysis
Authors: Sakiko Tabata, Kazuo Imai, Shuichi Kawano, Mayu Ikeda, Tatsuya Kodama, Kazuyasu Miyoshi, Hirofumi Obinata, Satoshi Mimura, Tsutomu Kodera, Manabu Kitagaki, Michiya Sato, Satoshi Suzuki, Toshimitsu Ito, Yasuhide Uwabe, Kaku Tamura
Journal: The Lancet Infectious Diseases (2020)
Bright future for endoscopy: the new frontier of gastric cancer secondary prevention
Authors: Jan Bornschein, Massimo Rugge
Journal: Gut (2020)

‘Can we replace histology assessment (of gastritis) also in the West?’ is the question that Marcos et al ask readers of their interesting study conducted at the Portuguese Oncology Institute in Porto.1 The study further examines the clinical value of the group’s promising approach to the endoscopic grading of gastric intestinal metaplasia (EGGIM) to facilitate the direct stratification of gastritis patients by their individual gastric cancer (GC) risk. The aim is to establish an endoscopy-based rationale for further endoscopic surveillance of patients at higher risk of GC. The authors conclude that endoscopy can reliably stratify GC risk. This would simplify everyday practice in terms of the GC risk assessment and management of patients with preneoplastic conditions, that is, glandular atrophy and intestinal metaplasia (IM).

Any patient-centred cancer prevention should include a set of variables that can be classified according to their invasiveness, reliability and cost. In the setting of GC prevention, there are some firmly established clinicopathological variables: (1) country-specific epidemiology and the socioeconomic setting; (2) feasibility of testing and treating Helicobacter pylori , the leading causative agent; (3) the use of reliable biomarkers (including the so-called ‘gastric serology’ or assessment of serum pepsinogens, and more sophisticated molecular markers); (4) endoscopy (as the main source of …
Inosine is an alternative carbon source for CD8+-T-cell function under glucose restriction
Authors: Tingting Wang, J. N. Rashida Gnanaprakasam, Xuyong Chen, Siwen Kang, Xuequn Xu, Hua Sun, Lingling Liu, Hayley Rodgers, Ethan Miller, Teresa A. Cassel, Qiushi Sun, Sara Vicente-Muñoz, Marc O. Warmoes, Penghui Lin, Zayda Lizbeth Piedra-Quintero, Mireia Guerau-de-Arellano, Kevin A. Cassady, Song Guo Zheng, Jun Yang, Andrew N. Lane, Xiaotong Song, Teresa W.-M. Fan, Ruoning Wang
Journal: Nature Metabolism (2020)

T cells undergo metabolic rewiring to meet their bioenergetic, biosynthetic and redox demands following antigen stimulation. To fulfil these needs, effector T cells must adapt to fluctuations in environmental nutrient levels at sites of infection and inflammation. Here, we show that effector T cells can utilize inosine, as an alternative substrate, to support cell growth and function in the absence of glucose in vitro. T cells metabolize inosine into hypoxanthine and phosphorylated ribose by purine nucleoside phosphorylase. We demonstrate that the ribose subunit of inosine can enter into central metabolic pathways to provide ATP and biosynthetic precursors, and that cancer cells display diverse capacities to utilize inosine as a carbon source. Moreover, the supplementation with inosine enhances the anti-tumour efficacy of immune checkpoint blockade and adoptive T-cell transfer in solid tumours that are defective in metabolizing inosine, reflecting the capability of inosine to relieve tumour-imposed metabolic restrictions on T cells.
THU0646-HPR EXPLORING THE ROLE OF NURSE IN RHEUMATIC CARE AND FEASIBILITY OF ENHANCING TREAT TO TARGET STRATEGIES IN JAPAN.
Authors: M. Fusama, M. Uda, H. Matsumura, Y. Van Eijk-Hustings, S. Oliver, H. Nakahara
Journal: Annals of the Rheumatic Diseases (2020)

Background: The role of rheumatology nurses is considered important for the implementation of T2T [1]. For nurses’ contribution to implementation of the T2T strategy, it is necessary to explore the nurses’ opinion on their roles in real clinical practice. Objectives: The aim of this study is to evaluate what is required for nurses to implement T2T in real clinical practice in Japan. Methods: Registered nurses engaged in rheumatic care in clinical practice in Japan were enrolled. Focus group interviews were conducted exploring ‘What is necessary for RA nurses to implement T2T’using semi-structured interviews. Data analysis was used with Krippendorff’s content analysis method. Results: 24 nurses (all females) from 10 hospitals were enrolled in this study. The results of the qualitative analysis were categorized in 10 main categories, derived from 37 subcategories based on 64 different codes: (1) provide basic knowledge of RA, (2) provide knowledge of RA drugs, (3) provide knowledge and skills of self-monitoring, (4) enhance self-efficacy and support self-management, (5) support decision-making, (6) psychological and social support, (7) understand the diversity and feelings of patients and their families, (8) support based on individual needs, (9) ensure continuing educational opportunities for nurses to enable the provision of high quality care, (10) collaborate with multidisciplinary teams. These categories are mostly covered in the contents of the 2018 updated EULAR recommendations for the role of nurses except “evidence-based rheumatic care”, “telehealth” and “comprehensive participation in disease management”. Conclusion: These findings indicate the areas of exploration including further educational and training needs, attitudes and the professional scope for nurses to extend their roles to provide greater value to patient care. In Japan, evidence-based RA nursing and telehealth systems have not yet been established. In addition, therapeutic intervention by nurses and nurse-led clinic are not permitted. Our results might reflect this situation and possibly elucidates the gap between EULAR’s evidence-based recommendations and opinions of Japanese nurses working in daily clinical practice. As evidence-based nursing is considered to be crucial from both cost-effectiveness and improvement of patients QOL, this result also might shed light on what we need for future better rheumatic nursing in Japan. References: [1]van Eijk- Hustings Y, et al. Ann Rheum Dis 2012;71: 13–19. Disclosure of Interests: MIE FUSAMA: None declared, Miyabi Uda: None declared, Harumi Matsumura: None declared, Yvonne van Eijk-Hustings Grant/research support from: grand from sanofi and UCB, Consultant of: fee from amgen, Susan Oliver: None declared, Hideko Nakahara: None declared