tbuckley/cabot-search huggingface dataset:
INNV-05. SOCIAL MEDIA AND “TWEET CHAT ANALYSES” TO INFORM QOL AND PALLIATIVE CARE NEEDS IN PATIENTS WITH PRIMARY BRAIN TUMORS
Authors: Liz Salmi, Shirley Otis-Green, Adam Hayden, Lynne Taylor, Bethany Kwan
Journal: Neuro-Oncology (2019)

Abstract BACKGROUND Despite a standard of care protocol for the treatment of brain cancer, patients often suffer motor and cognitive deficits and chronic exposure to stress and anxiety, detrimental to patient quality of life (QOL). Palliative care addresses patient and care partner (caregiver) QOL needs as a complement to curative treatment, using a team-based, multidisciplinary approach. Elements of palliative care that are highest priority for patients with brain cancer are not known. METHODS A multi-stakeholder group including clinicians, researchers, patients, and care partners convened (hereafter: “stakeholders”), led jointly by a brain cancer patient and health services researcher. The stakeholders identified QOL needs for patients with brain cancer and their care partners, and mapped these needs onto a brain cancer-specific palliative care model. In 2018, patients, researchers, and clinicians participated in two moderated “tweet chats” to test and further inform QOL definitions and palliative care needs (n=79). RESULTS Thematic analysis of tweet chat transcripts revealed patients and care partners were most concerned by: challenging behaviors resulting from tumor and resulting treatment; depression and anxiety; changes in sexuality/intimacy loss; grief over the loss of identity and things one previously enjoyed/was able to do; financial toxicity; changes in close relationships; and dependence on a broader social network. The stakeholders used this work to inform a set of QOL needs and corresponding palliative care elements. Each need was mapped onto a corresponding element for development of a palliative care model. Further research questions were identified to inform further research in this area. CONCLUSIONS Patients with brain cancer have complex QOL needs beyond symptom management. A palliative care model for brain cancer should include a multidisciplinary care team including care partner support and education. In addition to the palliative care physician, additional disciplines may include a social worker, chaplain, mental health professional, and rehabilitative services therapists.
LIC-R2 Values Predict Severity of SCD: Baseline Data from Licnet-S
Authors: Rosario Di Maggio, Angela Vitrano, Carmelo Fidone, Alessandra Quota, Daniela Fiorino, Calogera Gerardi, Saveria Campisi, Lorenzo Tesé, Vincenzo Santoro, Barone Rita, Giangreco Antonino, Paolo Rigano, Lorella Pitrolo, Aurelio Maggio
Journal: Blood (2019)
EPID-04. ASSOCIATION BETWEEN URBANICITY AND SURGICAL TREATMENT AMONG PATIENTS WITH PRIMARY GLIOBLASTOMA IN THE UNITED STATES
Authors: Gino Cioffi, David Cote, Nirav Patil, James Wright, Christina Wright, Andrew Sloan, Quinn Ostrom, Carol Kruchko, Jill Barnholtz-Sloan
Journal: Neuro-Oncology (2019)

Abstract BACKGROUND Glioblastoma (GBM) is the most common malignant brain and other central nervous system (CNS) tumor and also the most fatal. Extent of surgical resection is one of the most significant factors associated with improved survival. Historically, patients living in non-metropolitan counties have limited access to optimal treatment and healthcare services. The aim of this study is to determine if there is an association between urbanicity and surgical treatment patterns among patients with primary GBM. METHODS Cases with histologically-confirmed, primary GBM diagnosed between 2005 and 2015 were obtained from the Central Brain Tumor Registry of the United States (CBTRUS). Site specific surgery codes for brain and CNS defined surgery were grouped as follows: gross total resection (GTR; 30,55), subtotal resection (STR; 21, 40), biopsy only (20) and none (00). Urbanicity was defined using the 2013 USDA Rural Urban Continuum (RUC) Code Definitions (metropolitan: RUC 1–3, non-metropolitan: RUC 4–9). Multivariable logistic regression models were constructed to assess the association between urbanicity and receipt of surgical treatment (GTR/STR vs. biopsy only/none) and extent of resection (GTR vs. STR), adjusted for age at diagnosis, sex, race, U.S. regional division, and primary site of tumor. RESULTS Residence in a metropolitan county was significantly associated with receiving surgical treatment among patients with GBM, with patients residing in non-metropolitan counties 7% less likely to receive surgical treatment (adjusted OR=0.93, 95% CI: 0.89–0.96, P value: &lt; .0001). Among those who received surgical treatment, metropolitan status was not significantly associated with receiving GTR vs. STR (adjusted OR=0.99, 95% CI: 0.94–1.04, P value: 0.620). CONCLUSIONS Among U.S. patients with GBM, urbanicity is associated with receipt of surgical treatment, but among patients who receive surgery, was not associated with extent of resection. These results point to potential differences in access to healthcare for those in non-metropolitan areas that warrant further exploration.
Dose-Dense Rituximab Improves Outcome of Elderly Patients with Poor-Prognosis Diffuse Large B-Cell Lymphoma (DLBCL): Results of the DENSE-R-CHOP-14 Trial of the German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL).
Authors: Michael Pfreundschuh, Samira Zeynalova, Viola Poeschel, Mathias Haenel, Norbert Schmitz, Manfred Hensel, Marcel Reiser, Markus Loeffler, Joerg Schubert
Journal: Blood (2007)
Age-Specific Incidence of Melanoma in the United States
Authors: Kelly G. Paulson, Deepti Gupta, Teresa S. Kim, Joshua R. Veatch, David R. Byrd, Shailender Bhatia, Katherine Wojcik, Aude G. Chapuis, John A. Thompson, Margaret M. Madeleine, Jennifer M. Gardner
Journal: JAMA Dermatology (2019)

Melanoma is epidemiologically linked to UV exposure, particularly childhood sunburn. Public health campaigns are increasing sun-protective behavior in the United States, but the effect on melanoma incidence is unknown.To examine the incidence of melanoma in the United States and whether any age-specific differences are present.Observational, population-based registry data were extracted on July 3, 2018, from the combined National Program of Cancer Registries-Surveillance Epidemiology and End Results United States Cancer Statistics database for 2001-2015. Deidentified data for 988 103 cases of invasive melanoma, with International Classification of Diseases for Oncology histologic categorization codes 8720 to 8790, were used for analysis. Data analysis was performed from July 1, 2018, to March 1, 2019.The annual rates of melanoma in pediatric, adolescent, young adult, and adult age groups were determined. Analyses were stratified by sex, and incidence rates were age-adjusted to the 2000 US standard population. Annual percentage change (APC) in incidence rate was calculated over the most recent decade for which data were available (2006-2015) using the weighted least squares method.In 2015, 83 362 cases of invasive melanoma were reported in the United States, including 67 in children younger than 10 years, 251 in adolescents (10-19 years), and 1973 in young adults (20-29 years). Between 2006 and 2015, the overall incidence rate increased from 200.1 to 229.1 cases per million person-years. In adults aged 40 years or older, melanoma rates increased by an APC of 1.8% in both men (95% CI, 1.4%-2.1%) and women (95% CI, 1.4%-2.2%). In contrast, clinically and statistically significant decreases were seen in melanoma incidence for adolescents and young adults. Specifically, incidence rates decreased by an APC of -4.4% for male adolescents (95% CI, -1.7% to -7.0%), -5.4% for female adolescents (95% CI, -3.3% to -7.4%), -3.7% for male young adults (95% CI, -2.5% to -4.8%), and -3.6% for female young adults (95% CI, -2.8% to -4.5%). Data on skin pigmentation and sun protection history were unavailable; similar trends were observed with data limited to non-Hispanic whites. Young adult women appeared to have twice the risk of melanoma as young adult men.The incidence of invasive melanoma in the United States appeared to decrease in adolescents and young adults from 2006 to 2015, and this finding contrasted with increases in older populations. These incidence trends suggest that public health efforts may be favorably influencing melanoma incidence in the United States.
Olfactomedin 4 Inhibits Erythroid Differentiation of Leukemic Cell Lines Induced By TGF-β: A Model of Preferential Commitment of Del(13q) Hematopoietic Stem Cells in Immune-Mediated Bone Marrow Failure
Authors: Kohei Thi Hosokawa, Kohei Hosokawa, Tanabe Mikoto, Md Mohiuddin, Takeshi Yoroidaka, Hiroki Mizumaki, Tatsuya Imi, Masaya Ueno, Atsushi Hirao, Shinji Nakao
Journal: Blood (2019)
National Burden Estimates of healthy life lost in India, 2017: an analysis using direct mortality data and indirect disability data
Authors: Geetha R Menon, Lucky Singh, Palak Sharma, Priyanka Yadav, Shweta Sharma, Shrikant Kalaskar, Harpreet Singh, Srividya Adinarayanan, Vasna Joshua, Vaitheeswaran Kulothungan, Jeetendra Yadav, Leah K Watson, Shaza A Fadel, Wilson Suraweera, M Vishnu Vardhana Rao, R S Dhaliwal, Rehana Begum, Prabha Sati, Dean T Jamison, Prabhat Jha
Journal: The Lancet Global Health (2019)

Many countries, including India, seek locally constructed disease burden estimates comprising mortality and loss of health to aid priority setting for the prevention and treatment of diseases. We created the National Burden Estimates (NBE) to provide transparent and understandable disease burdens at the national and subnational levels, and to identify gaps in knowledge.To calculate the NBE for India, we combined 2017 UN death totals with national and subnational mortality rates for 2010-17 and causes of death from 211 166 verbal autopsy interviews in the Indian Million Death Study for 2010-14. We calculated years of life lost (YLLs) and years lived with disability (YLDs) for 2017 using published YLD-YLL ratios from WHO Global Health Estimates. We grouped causes of death into 45 groups, including ill-defined deaths, and summed YLLs and YLDs to calculate disability-adjusted life-years (DALYs) for these causes in eight age groups covering rural and urban areas and 21 major states of India.In 2017, there were about 9·7 million deaths and 486 million DALYs in India. About three quarters of deaths and DALYs occurred in rural areas. More than a third of national DALYs arose from communicable, maternal, perinatal, and nutritional disorders. DALY rates in rural areas were at least twice those of urban areas for perinatal and nutritional conditions, chronic respiratory diseases, diarrhoea, and fever of unknown origin. DALY rates for ischaemic heart disease were greater in urban areas. Injuries caused 11·4% of DALYs nationally. The top 15 conditions that accounted for the most DALYs were mostly those causing mortality (ischaemic heart disease, perinatal conditions, chronic respiratory diseases, diarrhoea, respiratory infections, cancer, stroke, road traffic accidents, tuberculosis, and liver and alcohol-related conditions), with disability mostly due to a few conditions (nutritional deficiencies, neuropsychiatric conditions, vision and other sensory loss, musculoskeletal disorders, and genitourinary diseases). Every condition that was common in one part of India was uncommon elsewhere, suggesting state-specific priorities for disease control.The NBE method quantifies disease burden using transparent, intuitive, and reproducible methods. It provides a simple, locally operable tool to aid policy makers in priority setting in India and other low-income and middle-income countries. The NBE underlines the need for many more countries to collect nationally representative cause of death data, paired with focused surveys of disability.Ministry of Health and Family Welfare, Government of India.
NCMP-04. OPSOCLONUS-MYOCLONUS SYNDROME ASSOCIATED WITH CONTACTIN-ASSOCIATED PROTEIN-LIKE 2 AUTOANTIBODY IN THE SETTING OF NON-SMALL CELL LUNG CARCINOMA
Authors: Christian Rosenow, Sara Dawit, Katharine Henry, Luca Farrugia, Akanksha Sharma, Marie Grill
Journal: Neuro-Oncology (2019)

Abstract INTRODUCTION Opsoclonus–myoclonus syndrome (OMS) is a rare neurological disorder characterized by spontaneous multidirectional saccadic eye movements, myoclonus, and ataxia. It is suspected to be an autoimmune mediated process precipitated by a paraneoplastic or infectious trigger. Among the pediatric population, OMS is often associated with neuroblastoma and anti-Hu antibody. Paraneoplastic syndromes in adults manifesting as OMS are most commonly described in breast, gynecological and small cell lung cancer with associated anti-neuronal antibodies (ANNA-2; anti-Ri). We describe the first case of OMS associated with lung adenocarcinoma and Contactin-associated protein-like 2 (Caspr2) antibody. CASE REPORT: A 46-year-old-woman with history of limited small cell lung cancer (SCLC) status-post chemotherapy with cisplatin and etoposide and prophylactic whole brain radiation, presented with new onset gait instability, nausea, vomiting, vertigo, and opsoclonus. Two months prior to her presentation, a chest computed topography (CT) revealed no evidence of recurrent disease. Brain MRI revealed T2 hyperintensities in the white matter and central pons presumably related to chronic small vessel ischemic changes, unchanged from prior imaging. CSF studies revealed normal cell count, glucose, and protein. Gram stain, culture and meningoencephalitis panel were negative. Her paraneoplastic panel revealed a positive Caspr2 antibody. A repeat CT chest for cancer surveillance revealed a new lung mass. Immunotherapy treatment included plasmapheresis, corticosteroids, and intravenous immunoglobulin therapy. She underwent a biopsy of the new pulmonary lesion and the pathology was consistent with non-small cell lung carcinoma. Her symptoms slowly improved after treatment. Unfortunately, her disease progressed on repeat PET scan despite surgical resection of the lung mass. She ultimately elected for hospice. CONCLUSION We report a novel antibody, Caspr2, occurring in association with paraneoplastic OMS. While SCLC is the most common neoplasm associated with OMS among adults, non-small cell lung carcinoma should be considered. Prompt immunotherapy and neoplasm treatment may result in improvement.
Hematopoietic Recovery after in-Vivo T-Cell Depleted Allogeneic Stem Cell Transplant- Effects of ABO Incompatibility, Rhesus Incompatibility and Acute Gvhd
Authors: Usama Gergis, Naima Ali Al-Mulla, Segovia Javier, Rania Hafez, Adrienne A. Phillips, Sebastian Mayer, Tsiporah B. Shore, Jing-ming Hsu, Ronit Slotky, Ljiljana V. Vasovic, Melissa M. Cushing, Koen van Besien
Journal: Blood (2016)
Outcomes in Patients with Splenic Marginal Zone Lymphoma or Marginal Zone Leukemia/Lymphoma Treated with Immunotherapy, Chemoimmunotherapy, or Chemotherapy.
Authors: Apostolia-Maria Tsimberidou, Daniel Catovsky, Ellen Schlette, Susan O’Brien, Hagop Kantarjian, William G. Wierda, Sijin Wen, Susan Lerner, Michael J. Keating
Journal: Blood (2005)
Impact of pulmonary disease on the prognosis in heart failure with preserved ejection fraction: the TOPCAT trial
Authors: Sergio H.R. Ramalho, Brian L. Claggett, Nancy K. Sweitzer, James C. Fang, Sanjiv J. Shah, Inder S. Anand, Bertram Pitt, Eldrin F. Lewis, Marc A. Pfeffer, Scott D. Solomon, Amil M. Shah
Journal: European Journal of Heart Failure (2019)
Early Intracranial Hemorrhages in Acute Promyelocytic Leukemia: Analysis of Neuroradiological and Clinico-Biological Parameters
Authors: Carmelo Gurnari, Francesca Di Giuliano, Mariadomenica Divona, Alfonso Piciocchi, Laura Cicconi, Adriano Venditti, Maria Ilaria Del Principe, William Arcese, Francesco Lo-Coco, Francesco Garaci, Maria Teresa Voso
Journal: Blood (2019)
Endometrial cancer recurrence: Adjuvant high-dose rate vaginal brachytherapy (HDR) versus HDR with whole pelvic radiation.
Authors: Jeannine A Villella, Thomas Palaia, Eva Chalas, Patricia Patrick, Jonathan A. Haas
Journal: Journal of Clinical Oncology (2012)

e15504 Background: Investigators hypothesize that patients with endometrioid carcinoma of the endometrium treated with adjuvant high-dose-rate vaginal brachytherapy (HDR) alone vs. HDR with whole pelvic radiation (WPXRT) have similar recurrence patterns. Methods: Patients reated with any adjuvant HDR between March 2005 and January 2011 were included retrospectively. Demographic, pathologic and treatment data was extracted from the medical record. These clinical data were compared among subjects receiving HDR only vs. HDR with 4500 cGy whole pelvic radiation using t-tests, Mann-Whitney tests, and chi-square analyses as appropriate. Results: One hundred eighty-six patients received adjuvant HDR. Fifty eight were excluded from analyses (46 based on non-endometrioid histology; 12 lost to follow-up). Among the sample of 128 subjects, 56 were treated with HDR only vs. 72 with HDR and WPXRT (43.8% vs. 56.2%, respectively). Subjects were similar in age, body mass index, and the existence of medical co morbidities. Of the 72 patients receiving HDR and WPXRT, 28 (38.9) were staged IA-IC, 28 (38.9) were staged as IIA-IIB, 11 (15.4%) were staged as IIIA-IIIC, 1 was staged as IVA-IVB (1.4%) and 4 (5.5%) was unstaged at diagnosis. Complications were similar between the groups. A total of 5 subjects experienced a recurrence, 1 who received HDR only vs. 4 who received HDR and WPXRT (1.8% vs. 5.6%, respectively, p=0.27). The subject treated with HDR was diagnosed with a grade 1 endometrioid carcinoma and had recurrence in the lung. Of the 4 subjects treated with HDR and WPXRT, 3 had recurrence in the vaginal cuff and 1 had recurrence in the peri-aortic lymph nodes. Conclusions: Recurrence was low among all subjects and did not differ among those who received HDR therapy only compared to HDR therapy with whole pelvic radiation. Investigators plan to conduct additional studies with a larger sample size to determine whether a difference in recurrence exists while adjusting for disease stage and total treatment dosage. If such confirmatory evidence is found, HDR brachytherapy alone may be a viable alternative to the additional radiation exposure of WPXRT in treating patients with endometrioid carcinoma of the endometrium.
A Clinically-Indolent Variant of Extranodal NK/T Cell Lymphoma with Unique Immunophenotypic Profile and Superior Outcome
Authors: Fabiola Valvert, Elizabeth Solorzano, Edward Briercheck, Marcos Mauricio Siliézar Tala, Yasodha Natkunam, David M. Weinstock, Oscar Silva
Journal: Blood (2019)
BMT CTN Protocol 1506: A Phase 3 Trial of Gilteritinib As Maintenance Therapy after Allogeneic Hematopoietic Stem Cell Transplantation in Patients with FLT3-ITD+ AML
Authors: Mark J. Levis, Mehdi Hamadani, Brent R. Logan, Matt Rosales, David Delgado, Erkut Bahceci, Steven Devine, Mary M. Horowitz, Yi-Bin Chen
Journal: Blood (2019)
Nerve Regeneration: Repairing Transected Peripheral Nerve Using a Biomimetic Nerve Guidance Conduit Containing Intraluminal Sponge Fillers (Adv. Healthcare Mater. 21/2019)
Authors: Yuanjing Hou, Xinyu Wang, Zongrui Zhang, Jing Luo, Zhengwei Cai, Yiyu Wang, Yi Li
Journal: Advanced Healthcare Materials (2019)

Repair of segmental nerve defects remains a troublesome issue in the clinic. In article number 1900913 by Xinyu Wang and co-workers, an innovative nerve guide conduit (ISF-NGC) is constructed by combining a nanofibrous external conduit and intraluminal sponge fillers. The ISF-NGC provides extracellular matrix (ECM)-like architecture for axonal regrowth and effectively facilitates nerve regeneration.
A proposal for changes to the European Union syphilis surveillance case definition using evidence from evaluations in Ireland
Authors: Naomi Petty-Saphon, Melissa Brady, Gillian Cullen, Fionnuala Cooney, Phil Downes, Sarah Doyle, Paul Holder, Fiona Lyons, Derval Igoe
Journal: Eurosurveillance (2019)

Syphilis remains a disease of public health importance, with considerable health effects if not treated. Concurrent infection with syphilis and untreated HIV facilitates HIV transmission. The incidence of syphilis in Europe has been increasing, particularly among men who have sex with men (MSM) and in MSM with HIV. However, there is heterogeneity among countries in the case definition used for syphilis and in reported syphilis notification rates. In Ireland, we have undertaken a number of refinements of the national syphilis surveillance system since 2014, including refinement of the laboratory thresholds for notification (rapid plasma reagin 1:16 and/or positive IgM). This article outlines the steps taken and some of the challenges we faced. Our current case definition now accurately reflects the epidemiology of syphilis in Ireland and our current surveillance provides timely information for action, while not reducing the sensitivity of the system too much. For countries where surveillance is driven mainly by laboratory reporting and where obtaining clinical details is challenging, these thresholds for notification may be a pragmatic solution.
99mTc-Labeled Native RBC Scintigraphy in Distinguishing Polysplenia From Abdominal Masses in a Patient With Situs Inversus Totalis
Authors: Peipei Wang, Hongli Jing, Fang Li, Zhenghua Wang, Li Huo
Journal: Clinical Nuclear Medicine (2019)

A 39-year-old previously healthy woman presented possible hematuria. An ultrasound examination showed right adrenal mass and suggested pheochromocytoma. A Tc-HYNIC-TOC SPECT/CT was performed, which incidentally detected situs inversus totalis and suspicion of polysplenia without definite normal spleen in the right upper abdomen. In order to differentiate the polysplenia from other etiologies, a heat-damaged Tc RBC scintigraphy was performed. The images showed significant activity in the multiple soft tissue nodules in the posterior right abdomen, consistent with ectopic polysplenia.
The Role of Decreased TIM-3 Expression of Natural Killer Cells in the Immune Pathogenesis of Severe Aplastic Anemia
Authors: Rong Fu, Shaoxue Ding, Chunyan Liu, Bingnan Liu, Hui Liu, Liu Zhaoyun, Tong Chen, Tian Zhang, Zonghong Shao, Ting Wang
Journal: Blood (2019)