tbuckley/cabot-search huggingface dataset:
Tripartite Motif‐Containing 27 Attenuates Liver Ischemia/Reperfusion Injury by Suppressing Transforming Growth Factor β–Activated Kinase 1 (TAK1) by TAK1 Binding Protein 2/3 Degradation
Authors: San‐Yang Chen, Hua‐Peng Zhang, Jie Li, Ji‐Hua Shi, Hong‐Wei Tang, Yi Zhang, Jia‐Kai Zhang, Pei‐Hao Wen, Zhi‐Hui Wang, Xiao‐Yi Shi, Yu‐Ting He, Bo‐Wen Hu, Han Yang, Wen‐Zhi Guo, Shui‐Jun Zhang
Journal: Hepatology (2020)

Background and Aims Hepatic ischemia‐reperfusion (I/R) injury, which mainly involves inflammatory responses and apoptosis, is a common cause of organ dysfunction in liver transplantation (LT). As a critical mediator of inflammation and apoptosis in various cell types, the role of tripartite motif‐containing (TRIM) 27 in hepatic I/R injury remains worthy of study. Approach and Results This study systemically evaluated the putative role of TRIM27/transforming growth factor β–activated kinase 1 (TAK1)/JNK (c‐Jun N‐terminal kinase)/p38 signaling in hepatic I/R injury. TRIM27 expression was significantly down‐regulated in liver tissue from LT patients, mice subjected to hepatic I/R surgery, and hepatocytes challenged by hypoxia/reoxygenation (H/R) treatment. Subsequently, using global Trim27 knockout mice ( Trim27‐ KO mice) and hepatocyte‐specific Trim27 transgenic mice ( Trim27‐ HTG mice), TRIM27 functions to ameliorate liver damage, reduce the inflammatory response, and prevent cell apoptosis. In parallel in vitro studies, activating TRIM27 also prevented H/R‐induced hepatocyte inflammation and apoptosis. Mechanistically, TRIM27 constitutively interacted with the critical components, TAK1 and TAK1 binding protein 2/3 (TAB2/3), and promoted the degradation of TAB2/3, leading to inactivation of TAK1 and the subsequent suppression of downstream JNK/p38 signaling. Conclusions TRIM27 is a key regulator of hepatic I/R injury by mediating the degradation of TAB2/3 and suppression of downstream TAK1‐JNK/p38 signaling. TRIM27 may be a promising approach to protect the liver against I/R‐mediated hepatocellular damage in transplant recipients.
European Association of Urology Guidelines Office Rapid Reaction Group: An Organisation-wide Collaborative Effort to Adapt the European Association of Urology Guidelines Recommendations to the Coronavirus Disease 2019 Era
Authors: Maria J. Ribal, Philip Cornford, Alberto Briganti, Thomas Knoll, Stavros Gravas, Marek Babjuk, Christopher Harding, Alberto Breda, Axel Bex, Jens J. Rassweiler, Ali S. Gözen, Giovannalberto Pini, Evangelos Liatsikos, Gianluca Giannarini, Alex Mottrie, Ramnath Subramaniam, Nikolaos Sofikitis, Bernardo M.C. Rocco, Li-Ping Xie, J. Alfred Witjes, Nicolas Mottet, Börje Ljungberg, Morgan Rouprêt, Maria P. Laguna, Andrea Salonia, Gernot Bonkat, Bertil F.M. Blok, Christian Türk, Christian Radmayr, Noam D. Kitrey, Daniel S. Engeler, Nicolaas Lumen, Oliver W. Hakenberg, Nick Watkin, Rizwan Hamid, Jonathon Olsburgh, Julie Darraugh, Robert Shepherd, Emma-Jane Smith, Christopher R. Chapple, Arnulf Stenzl, Hendrik Van Poppel, Manfred Wirth, Jens Sønksen, James N’Dow
Journal: European Urology (2020)
18F-FDG PET/CT and Serial Chest CT Findings in a COVID-19 Patient With Dynamic Clinical Characteristics in Different Period
Authors: Chunbao Liu, Jun Zhou, Liang Xia, Xiaojie Cheng, Diyu Lu
Journal: Clinical Nuclear Medicine (2020)

Neurological symptoms and gastrointestinal symptoms were rare at onset in COVID-19. Here we report a 37-year-old man with vertigo, fever, and diarrhea symptoms as the first manifestation. F-FDG PET/CT spotted multiple ground glass opacity (GGO) lesions in the lungs, with increased tracer uptake in both lung GGOs and the whole colon. Serial CT examinations showed the emersion and dissipation of lung GGOs. We illustrate the symptoms initiation, the laboratory test results, the imaging examination, and the treatment strategy in the duration of COVID-19 with a timeline chart.
Cannabinoids drive Th17 cell differentiation in patients with rheumatic autoimmune diseases
Authors: Konstantin Kotschenreuther, Iris Waqué, Shuaifeng Yan, Anja Meyer, Thom Haak, Julia von Tresckow, Joanna Schiller, Lydia Gloyer, Mara Dittrich-Salamon, David M. Kofler
Journal: Cellular and Molecular Immunology (2020)
Update on Vaccine-Derived Poliovirus Outbreaks — Worldwide, July 2019–February 2020
Authors: Mary M. Alleman, Jaume Jorba, Sharon A. Greene, Ousmane M. Diop, Jane Iber, Graham Tallis, Ajay Goel, Eric Wiesen, Steven G.F. Wassilak, Cara C. Burns
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

Circulating vaccine-derived polioviruses (cVDPVs) can emerge in areas with low poliovirus immunity and cause outbreaks* of paralytic polio (1-5). Among the three types of wild poliovirus, type 2 was declared eradicated in 2015 (1,2). The use of trivalent oral poliovirus vaccine (tOPV; types 1, 2, and 3 Sabin strains) ceased in April 2016 via a 1-month-long, global synchronized switch to bivalent OPV (bOPV; types 1 and 3 Sabin strains) in immunization activities (1-4). Monovalent type 2 OPV (mOPV2; type 2 Sabin strain) is available for cVDPV type 2 (cVDPV2) outbreak response immunization (1-5). The number and geographic breadth of post-switch cVDPV2 outbreaks have exceeded forecasts that trended toward zero outbreaks 4 years after the switch and assumed rapid and effective control of any that occurred (4). New cVDPV2 outbreaks have been seeded by mOPV2 use, by both suboptimal mOPV2 coverage within response zones and recently mOPV2-vaccinated children or contacts traveling outside of response zones, where children born after the global switch are fully susceptible to poliovirus type 2 transmission (2-4). In addition, new emergences can develop by inadvertent exposure to Sabin OPV2-containing vaccine (i.e., residual response mOPV2 or tOPV) (4). This report updates the January 2018-June 2019 report with information on global cVDPV outbreaks during July 2019-February 2020 (as of March 25, 2020)† (2). Among 33 cVDPV outbreaks reported during July 2019-February 2020, 31 (94%) were cVDPV2; 18 (58%) of these followed new emergences. In mid-2020, the Global Polio Eradication Initiative (GPEI) plans to introduce a genetically stabilized, novel OPV type 2 (nOPV2) that has a lower risk for generating VDPV2 than does Sabin mOPV2; if nOPV2 is successful in limiting new VDPV2 emergences, GPEI foresees the replacement of Sabin mOPV2 with nOPV2 for cVDPV2 outbreak responses during 2021 (2,4,6).
Undergraduate Medical Education and the Elective System: Experience with the Duke Curriculum, 1966–1975, <i>edited by James F. Gifford, Jr.; William G. Anlyan, M.D., Ewald W. Busse, M.D., and Thomas D. Kinney, M.D., supervising editors. Durham, N.C., Duke University Press, 1978, 243 pp., $9.75</i>
Authors: Roy Clouse
Journal: American Journal of Psychiatry (1979)
Exercise Tolerance according to the Definition of Airflow Obstruction in Smokers
Authors: J. Alberto Neder, Kathryn M. Milne, Danilo C. Berton, Juan P. de-Torres, Dennis Jensen, Wan C. Tan, Jean Bourbeau, Denis E. O’Donnell, J. Bourbeau, W. C. Tan, D. Jensen, S. D. Aaron, D. D. Sin, K. R. Chapman, F. Maltais, P. Hernandez, D. Marciniuk
Journal: American Journal of Respiratory and Critical Care Medicine (2020)
Radiation Recall Myositis Detected With 18F-FDG PET/CT After a Treatment of Cervical Cancer
Authors: Joanie Lemay, Myriam Bouchard, Étienne Rousseau
Journal: Clinical Nuclear Medicine (2020)

Abstract A 34-year-old woman, after being treated for cervical cancer, presented with severe pain in the inguinal and the upper abdominal region with restriction in range of motion of the trunk 71 days after radiation therapy and 19 days after receiving adjuvant gemcitabine and cisplatin chemotherapy. The 18 F-FDG PET/CT showed complete response to cancer treatment, but also revealed a localized inflammatory process that was delimited by radiation fields rather than anatomical structures, suggesting a radiation recall phenomenon.
Health impact assessment of Philadelphia's 2025 tree canopy cover goals
Authors: Michelle C Kondo, Natalie Mueller, Dexter H Locke, Lara A Roman, David Rojas-Rueda, Leah H Schinasi, Mireia Gascon, Mark J Nieuwenhuijsen
Journal: The Lancet Planetary Health (2020)

BackgroundCities across the world are undertaking ambitious projects to expand tree canopy by increasing the number of trees planted throughout public and private spaces. In epidemiological studies, greenspaces in urban environments have been associated with physical and mental health benefits for city dwellers. Greenworks Philadelphia is a plan to increase tree cover across Philadelphia (PA, USA) by the year 2025. We aimed to assess whether an increase in tree canopy or greenspace in Philadelphia could decrease mortality.MethodsWe did a greenspace health impact assessment to estimate the annual premature mortality burden for adult residents associated with projected changes in tree canopy cover in Philadelphia between 2014 and 2025. Using up-to-date exposure–response functions, we calculated the number of preventable annual premature deaths city-wide, and for areas of lower versus higher socioeconomic status, for each of three tree canopy scenarios: low, moderate and ambitious. The ambitious scenario reflected the city's goal of 30% tree canopy cover in each of the city's neighbourhoods; and low and moderate scenarios were based on the varying levels of plantable space across neighbourhoods.FindingsWe estimated that 403 (95% interval 298–618) premature deaths overall, including 244 (180–373) premature deaths in areas of lower socioeconomic status, could be prevented annually in Philadelphia if the city were able to meet its goal of increasing tree canopy cover to 30%.InterpretationBringing all of Philadelphia, and particularly its poorer neighbourhoods, up to the 30% goal of tree canopy cover is not without challenge. Nevertheless, policies are warranted that value urban greening efforts as health-promoting and cost-saving measures.FundingSpanish Ministry of Science, Innovation and Universities, and Generalitat de Catalunya.
Abstract 16280: Patient-Specific Computational Modeling Identifies Cryptogenic Stroke Patients With the Fibrotic Substrate for Atrial Fibrillation Perpetuation
Authors: Savannah F Bifulco, Sakher Sarairah, Zeinab Birjandian, Caroline H Roney, Steven A Niederer, Christian Mahnkopf, Peter Kühnlein, Marcel Mitlacher, David Tirschwell, Nazem W Akoum, Patrick M Boyle
Journal: Circulation (2019)

Introduction: Sub-clinical atrial fibrillation (AFib) is suspected as the cause of embolic stroke of unknown source (ESUS, i.e., cryptogenic stroke). However, AFib is only detected in ~30% of ESUS ...
Abstract 11505: Increased Mitochondrial Fission Plays a Critical Role in Low Glucose-Induced Endothelial Dysfunction
Authors: Michael J Tanner, Jingli Wang, Rong Ying, Mobin Malik, Amberly Branum, Tisha B Suboc, Allison Coulliard, Michael E Widlansky
Journal: Circulation (2015)

Introduction: Intensive glucose control in patients with Type 2 Diabetes Mellitus has resulted in increased incidence of hypoglycemia, often with elevated risk of adverse cardiovascular events. Studies of endothelial cells (ECs) and human arterioles exposed to a low glucose (LG) environment suggest the risk is mediated through a dysfunctional endothelium, characterized by greater reactive oxygen species (ROS) production and decreased nitric oxide (NO). Hypothesis: We propose that LG-induced endothelial dysfunction is driven by an imbalance in the fission/fusion process of mitochondrial networks within ECs. Methods: Human ECs were used to quantify mitochondrial fission and evaluate Mdivi-1, a fission inhibitor, following incubation in either LG (40 mg/dL) or normal glucose (NG, 90 mg/dL) physiologic environments for 2 hours. Similarly, human subcutaneous adipose arterioles subjected to either LG or NG, were used to detect ROS with MitoSOX and NO with DAF-2DA, ±Mdivi-1. Arteriole vasoactivity was measured ±Mdivi-1 in a dose-response manner to acetylcholine (Ach). This experiment was repeated employing siRNA to knockdown expression of the primary fission protein, Drp1. Results: More mitochondrial fragmentation was observed in ECs exposed to LG (LG vs NG: 3.2±0.6 vs 2.4 ±0.5, P&lt;0.05) and was attenuated by Mdivi-1 (P&lt;0.05). Vessels displayed increased ROS when exposed to LG (LG vs NG: 119.8±24.5 vs 80.1±21.8, P&lt;0.02) and levels decreased with Mdivi-1 (P=0.005). Available NO decreased in LG treated vessels (LG vs NG: 19.3±2.7 vs 31.7±3.2, P&lt;0.001) and improved with LG+Mdivi-1 (P&lt;0.05). LG exposed vessels displayed impaired endothelial dependent vasodilation and co-incubation with Mdivi-1 rescued the dilation response (LG vs LG+Mdivi-1 at [Ach] x10 -7 to 10 -5 M, P&lt;0.02). Likewise, knockdown of Drp1 also improved vasoactive response in the LG group (LG+scramble vs LG+siDrp1 at [Ach] x10 -7 to 10 -5 M, P&lt;0.003). Conclusion: Human arterioles exposed to LG conditions exhibit a decrease in NO, increased ROS and an impaired vasodilatory response correlating with dynamic mitochondrial changes. The role of the mitochondria in LG-induced endothelial dysfunction appears to be rooted in an increased mitochondrial fission response.
Smart Material Hydrogel Transfer Devices Fabricated with Stimuli‐Responsive Silk‐Elastin‐Like Proteins
Authors: Rachael N. Parker, Dana M. Cairns, Wenyao A. Wu, Kathryn Jordan, Chengchen Guo, Wenwen Huang, Zaira Martin‐Moldes, David L. Kaplan
Journal: Advanced Healthcare Materials (2020)

Abstract Three‐dimensional organoid tissue culture models are a promising approach for the study of biological processes including diseases. Advances in these tissue culture technologies improve in vitro analysis compared to standard 2D cellular approaches and are more representative of the physiological environment. However, a major challenge associated with organoid systems stems from the laborious processing involved in the analysis of large numbers of organoids. Here the design, characterization, and application of silk‐elastin‐like protein‐based smart carrier arrays for processing organoids is presented. Fabrication of hydrogel‐based carrier systems at room temperature result in organized arrays of organoids that maintain tissue culture plate orientation and could be processed simultaneously for histology. The system works by transfer of the organoids to the hydrogel arrays after which the material is subjected to 65 °C to induce hydrogel contraction to secure the organoids, resulting in multisample constructs and allowing for placement on a microscope slide. Histological processing and immunostaining of these arrayed cerebral organoids analyzed within the contracted silk‐elastin‐like proteins (SELP) show retention of native organoid features compared to controls without the hydrogel carrier system, thus avoiding any artifacts. These SELP carriers present a useful approach for improving efficiency of scaled organoid screening and processing.
Increased Prostate-Specific Membrane Antigen Uptake in Neurofibromatosis
Authors: Yingwei Wang, Cheng Zeng, Huipan Liu, Yue Chen, Wei Zhang
Journal: Clinical Nuclear Medicine (2020)

A 51-year-old man with 30-year neurofibromatosis and 2-month elevated prostate-specific antigen and back pain underwent a Ga-prostate-specific membrane antigen (PSMA) PET/CT scan for possible prostate cancer. Prostate-specific membrane antigen PET/CT imaging showed no abnormal uptake of the prostate. However, in addition to PSMA uptake in his left lung, thorax, and right ilium, which was confirmed being a lung squamous cell carcinoma by a lung biopsy, widespread uptake was also observed in his skin fibroma lesions. This case demonstrates that benign neurofibromatosis could have uptake of PSMA.
Tumor CD155 Expression Is Associated with Resistance to Anti-PD1 Immunotherapy in Metastatic Melanoma
Authors: Ailin Lepletier, Jason Madore, Jake S. O'Donnell, Rebecca L. Johnston, Xian-Yang Li, Elizabeth McDonald, Elizabeth Ahern, Anna Kuchel, Melissa Eastgate, Sally-Ann Pearson, Domenico Mallardo, Paolo A. Ascierto, Daniela Massi, Barbara Merelli, Mario Mandala, James S. Wilmott, Alexander M. Menzies, Charles Leduc, John Stagg, Bertrand Routy, Georgina V. Long, Richard A. Scolyer, Tobias Bald, Nicola Waddell, William C. Dougall, Michele W.L. Teng, Mark J. Smyth
Journal: Clinical Cancer Research (2020)

Resistance to anti-PD1-based immune checkpoint blockade (ICB) remains a problem for the treatment of metastatic melanoma. Tumor cells as well as host myeloid cells can express the immune checkpoint ligand CD155 to regulate immune cell function. However, the effect of tumor CD155 on the immune context of human melanoma has not been well described. This observational study characterizes tumor CD155 ligand expression by metastatic melanoma tumors and correlates results with differences in immune cell features and response to ICB.Pretreatment tumor specimens, from 155 patients with metastatic melanoma treated with ICB and from 50 patients treated with BRAF/MEK-directed targeted therapy, were assessed for CD155 expression by IHC. Intratumor T-cell features were analyzed using multiplex-immunohistofluorescence for CD8, PD1, and SOX10. Correlations were made between CD155 tumor level and bulk tumor RNA sequencing results, as well as clinical RECIST response and progression-free survival.High pretreatment CD155 tumor levels correlated with high parenchymal PD1+CD8+/CD8+ T-cell ratios (PD1tR) and poor response to anti-PD1 therapy. In PDL1 negative tumors, high CD155 tumor expression was associated with patients who had poor response to combination anti-PD1/CTLA4 therapy.Our findings are the first to suggest that tumor CD155 supports an increase in the fraction of PD1+CD8+ T cells in anti-PD1 refractory melanoma tumors and, further, that targeting the CD155 pathway might improve response to anti-PD1 therapy for patients with metastatic melanoma.
The Risks of Prescribing Hydroxychloroquine for Treatment of COVID-19—First, Do No Harm
Authors: Colette DeJong, Robert M. Wachter
Journal: JAMA Internal Medicine (2020)

Michael Liu, AB; Theodore L. Caputi, MPH; Mark Dredze, PhD; Aaron S. Kesselheim, MD, JD, MPH; John W. Ayers, PhD, MA
Clinical Progression of Chronic Lymphocytic Leukemia (CLL) Is Characterized By a Progressive Increase of the Exhausted T-Cell Phenotype and Immunosuppression Induced By Leukemic Cells
Authors: Isabel Jiménez, Sabela Bobillo, Pau Abrisqueta, Bárbara Tazón, Carles Palacio, Juan C Nieto, Júlia Carabia, Maria Jose Terol, Jose Garcia-Marco, Joan Boix, Magdalena Munuera, Lluis Puigdefàbregas, Elisa Roldán, Marta Crespo, Francesc Bosch
Journal: Blood (2017)
Withdrawal of low-dose prednisone in inactive SLE patients: Is there another alternative?
Authors: José Mario Sabio
Journal: Annals of the Rheumatic Diseases (2020)

I read with great interest, the recently published article in your journal titled ‘Withdrawal of low-dose prednisone in systemic lupus erythematosus (SLE) patients with a clinically quiescent disease for more than 1 year: a randomised clinical trial’ by Mathian et al .1 In this article, the authors conclude that the maintenance of long-term 5 mg prednisone in SLE patients with inactive disease prevents relapses. In the recent update of European League Against Rheumatism (EULAR) recommendations for the management of SLE,2 the experts say that the …
Abstract 11910: In vivo Release Pattern of Cardiac Troponin I in Non-ST Elevation Myocardial Infarction: Insights From an Intracardiac and Multi-Site Sampling Study
Authors: Sander A Damen, Etienne Cramer, Harry Suryapranata, Freek W Verheugt, Wim R Aengevaeren, Ton J Oude Ophuis, Helmut Gehlmann, Hendrik-Jan Dieker, Alan H Wu, Xander M van Wijk, Marc Brouwer
Journal: Circulation (2018)

Background: Use of disease specific cardiac troponin I (cTnI) forms have been suggested as the next step to improve cTnI assay specificity. Current knowledge on serum cTnI composition is only based...
Engineering the Live-Attenuated Polio Vaccine to Prevent Reversion to Virulence
Authors: Ming Te Yeh, Erika Bujaki, Patrick T. Dolan, Matthew Smith, Rahnuma Wahid, John Konz, Amy J. Weiner, Ananda S. Bandyopadhyay, Pierre Van Damme, Ilse De Coster, Hilde Revets, Andrew Macadam, Raul Andino
Journal: Cell Host & Microbe (2020)

The live-attenuated oral poliovirus vaccine (OPV or Sabin vaccine) replicates in gut-associated tissues, eliciting mucosa and systemic immunity. OPV protects from disease and limits poliovirus spread. Accordingly, vaccination with OPV is the primary strategy used to end the circulation of all polioviruses. However, the ability of OPV to regain replication fitness and establish new epidemics represents a significant risk of polio re-emergence should immunization cease. Here, we report the development of a poliovirus type 2 vaccine strain (nOPV2) that is genetically more stable and less likely to regain virulence than the original Sabin2 strain. We introduced modifications within at the 5' untranslated region of the Sabin2 genome to stabilize attenuation determinants, 2C coding region to prevent recombination, and 3D polymerase to limit viral adaptability. Prior work established that nOPV2 is immunogenic in preclinical and clinical studies, and thus may enable complete poliovirus eradication.
Association of Viewing the Films <i>Joker</i> or <i>Terminator: Dark Fate </i>With Prejudice Toward Individuals With Mental Illness
Authors: Damian Scarf, Hannah Zimmerman, Taylor Winter, Hannah Boden, Sarah Graham, Benjamin C. Riordan, John A. Hunter
Journal: JAMA Network Open (2020)

This survey study assesses the association of viewing the film Joker with level of prejudice toward individuals with mental illness.
Group 1 allergens, transported by mold spores, induce asthma exacerbation in a mouse model
Authors: Guadalupe Hernández‐Ramírez, Diego Pazos‐Castro, Elisa Gómez Torrijos, Alma Yuste Montalvo, Alejandro Romero‐Sahagun, Zulema González‐Klein, Lucia Jimeno‐Nogales, Maria M. Escribese, Alba Extremera Ortega, Emilio Nuñez‐Borque, Loreto Bustamante Orvay, Vanesa Esteban, Francisco Feo Brito, Domingo Barber, Jaime Tome‐Amat, María Garrido‐Arandia, Araceli Díaz‐Perales
Journal: Allergy (2020)

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Early subclinical tubulitis and interstitial inflammation in kidney transplantation have adverse clinical implications
Authors: Rajil B. Mehta, Srijan Tandukar, Dana Jorgensen, Parmjeet Randhawa, Puneet Sood, Chethan Puttarajappa, Adriana Zeevi, Amit D. Tevar, Sundaram Hariharan
Journal: Kidney International (2020)
Prognostic Value of Right Ventricular Longitudinal Strain in Patients With COVID-19
Authors: Yuman Li, He Li, Shuangshuang Zhu, Yuji Xie, Bin Wang, Lin He, Danqing Zhang, Yongxing Zhang, Hongliang Yuan, Chun Wu, Wei Sun, Yanting Zhang, Meng Li, Li Cui, Yu Cai, Jing Wang, Yali Yang, Qing Lv, Li Zhang, Mingxing Xie
Journal: JACC. Cardiovascular imaging (2020)