tbuckley/cabot-search huggingface dataset:
Azacytidine Sensitizes AML Cells for Effective Elimination By CD123 CAR T-Cells
Authors: Nadia El Khawanky, Amy Hughes, Wenbo Yu, Sanaz Taromi, Jade Clarson, Angel F. Lopez, Michael P. Brown, Justus Duyster, Timothy P. Hughes, Deborah L. White, Agnes S. M. Yong, Robert Zeiser
Journal: Blood (2019)
PD1.03 A Primer on Genetic Counseling on the Thoracic Oncology Unit. Family History of Lung Cancer in Two Independent Populations Tested for BRCA1 &amp; amp;2 and EGFR.
Authors: G. Pacheco-Cuellar, K. Campos-Gomez, J.J. Valdéz-Andrade, S. Campos-Gomez
Journal: Journal of Thoracic Oncology (2019)
Dietary management of maturity-onset diabetes.
Authors: J I Mann, H C Simpson
Journal: BMJ (1980)

nervosa.She was subject to recurrent hypoglycaemia and on one occasion had a grand mal fit.After a joint medicopsychiatric admission she was followed up in both clinics in conjunction.She remained at about 42 kg (standard 50 kg) until just after taking 0 levels at 16; she lost 4 kg in a few weeks, and was subsequently found dead in bed.A few missed periods and fluctuations in weight are commonplace in adolescence.Primary anorexia nervosa is liable to arise when lack of menses and weight loss come specifically to assuage high levels of adolescent anxiety.The combination of the illusion of self control, the safety of emotional regression, -and reaffirmation of parental concern may be rewarding enough to maintain and intensify weight-reducing behaviour.In our second patient the strains of puberty and adolescence were added to the psychological disturbance common in unstable diabetes3-leading to overdose, wristcutting, and finally anorexia nervosa.The reason for her death was un- certain but she did not have autonomic neuropathy, which can predispose to cardio- respiratory arrest in diabetes.4It seems that the association between anorexia nervosa and diabetes mellitus is neither excessively rare nor particularly common, but what would be expected by chance.However, since the secondary forms of anorexia nervosa merge into various neurotic reactions it is probable that a search among diabetics would produce an appreciable number with neurotic be- haviour which included an obsession with weight.
New Paradigms for the Mechanisms of Thrombopoietin Receptor Activation and Dysregulation By the JAK2V617F Mutation
Authors: Stephan Wilmes, Maximillian Hafer, Tess A Stanly, Ignacio Moraga, Joni Vuorio, Chetan Poojari, Vivek Sharma, Sara Löchte, Katiuska Pulgar Prieto, Julie A Tucker, Stevan R Hubbard, K.Christopher Garcia, Ilpo Vattulainen, Ian Hitchcock, Jacob Piehler
Journal: Blood (2019)
Patient Reported Outcomes (PROs) Show Superior Quality of Life (QOL) of Patients with Chronic Myeloid Leukemia (CML) Treated with First Compared to Newer Generations of Tyrosine Kinase Inhibitors (TKIs)
Authors: Adi Shacham, Lena Rosenman, Avi Leader, Giora Sharf, Pia Raanani, Uri Rozovski
Journal: Blood (2019)
Outcomes of Chronic Graft-Versus-Host Disease (cGVHD) Following Matched Sibling Donor (MSD) Versus Umbilical Cord Blood Transplant (UCBT)
Authors: Grigori Okoev, Daniel J. Weisdorf, John E. Wagner, Bruce R. Blazar, Margaret L. MacMillan, Todd E. DeFor, Aleksandr Lazaryan, Najla H El Jurdi, Shernan Holtan, Claudio G Brunstein, Brian C. Betts, Takuto Takahashi, Veronika Bachanova, Erica D. Warlick, Armin Rashidi, Mukta Arora
Journal: Blood (2019)
Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Ceramides
Authors: Varman T. Samuel, Gerald I. Shulman
Journal: New England Journal of Medicine (2019)

Insulin resistance is a precursor to and accelerant of coexisting conditions such as type 2 diabetes, atherosclerosis, and nonalcoholic liver disease. A recent study of mouse models implicates elevated levels of ceramide and their effect on mitochondrial function in the mediation of cellular insulin resistance.
RARE-02. SYMPTOMATIC SALIVARY GLAND-LIKE TUMORS OF THE SELLAR REGION: ADDITIONAL FEATURES AND REVIEW OF THE LITERATURE
Authors: Bette Kleinschmidt-DeMasters, Marc Rosenblum, Janice Kerr, Kevin Lillehei
Journal: Neuro-Oncology (2019)

Abstract INTRODUCTION Sellar symptomatic salivary gland-like tumors (SSGTs) are exceedingly rare, with less than a dozen case reports in the literature. They usually consist of amorphous colloid identical to Rathke cleft cyst (RCC) contents, but additionally the cyst wall contains a large, cohesive collection of benign salivary glands. We report two new examples, one of which represents the first instance of recurrence of symptoms 2 years after first surgery, the second time with cyst confined to infundibular stalk and causing severe gliosis, indicative of mass effect. The second example underscores that SSGT remains poorly recognized, even today amongst experts. METHODS One case each was retrieved from the files of University of Colorado Denver (UCD) and Memorial Sloan Kettering (MSK); the UCD case represents the sole example in 2000+ sellar region masses seen at our institution since 1997. The MSK case had been recently received in consultation. RESULTS Case 1 is a 20-year-old female who presented with 3 weeks of symptoms referable to obstructive hydrocephalus; neuroimaging disclosed a sellar/suprasellar 2.4 x 2.2 x 2.4 cm mass. Following surgical resection, SSGT was diagnosed. She received no adjuvant therapy, but recurrence of headaches and blurred vision 2 years later prompted her return to medical attention. MRI revealed a recurrent cyst confined to the center of a thickened, bulbous infundibular stalk. Second resection yielded amorphous mucin within the cystic and severely-gliotic infundibular stalk, but no salivary-type glands. She has been followed for the last 6 years without tumor recurrence. Case 2 is a 29-year-old female with headache. The lesion was seen initially by a neuropathologist at another institution before it was sent to MSK for consultation and SSGT was diagnosed. CONCLUSION Few pathologists or neuropathologists have encountered SSGT in their practices; case 1 produced recurrence and significant local stalk damage, features not previously reported.
Pulmonary xenon-129 MRI: new opportunities to unravel enigmas in respiratory medicine
Authors: Rachel L. Eddy, Grace Parraga
Journal: European Respiratory Journal (2019)

<b><sup>129</sup>Xe MRI provides rapid, sensitive, non-invasive, high spatial resolution and simultaneous measurements of pulmonary ventilation, tissue microstructure and gas exchange, and is poised for routine clinical assessments in patients with chronic lung disease</b>http://bit.ly/2PKkFcU
Optimizing Phylogenomics with Rapidly Evolving Long Exons: Comparison with Anchored Hybrid Enrichment and Ultraconserved Elements
Authors: Benjamin R Karin, Tony Gamble, Todd R Jackman
Journal: Molecular Biology and Evolution (2019)

Abstract Marker selection has emerged as an important component of phylogenomic study design due to rising concerns of the effects of gene tree estimation error, model misspecification, and data-type differences. Researchers must balance various trade-offs associated with locus length and evolutionary rate among other factors. The most commonly used reduced representation data sets for phylogenomics are ultraconserved elements (UCEs) and Anchored Hybrid Enrichment (AHE). Here, we introduce Rapidly Evolving Long Exon Capture (RELEC), a new set of loci that targets single exons that are both rapidly evolving (evolutionary rate faster than RAG1) and relatively long in length (&amp;gt;1,500 bp), while at the same time avoiding paralogy issues across amniotes. We compare the RELEC data set to UCEs and AHE in squamate reptiles by aligning and analyzing orthologous sequences from 17 squamate genomes, composed of 10 snakes and 7 lizards. The RELEC data set (179 loci) outperforms AHE and UCEs by maximizing per-locus genetic variation while maintaining presence and orthology across a range of evolutionary scales. RELEC markers show higher phylogenetic informativeness than UCE and AHE loci, and RELEC gene trees show greater similarity to the species tree than AHE or UCE gene trees. Furthermore, with fewer loci, RELEC remains computationally tractable for full Bayesian coalescent species tree analyses. We contrast RELEC to and discuss important aspects of comparable methods, and demonstrate how RELEC may be the most effective set of loci for resolving difficult nodes and rapid radiations. We provide several resources for capturing or extracting RELEC loci from other amniote groups.
Analysis of Predictive Factors for Early Response to Ruxolitinib in 266 Patients with Myelofibrosis from the Polish Adult Leukemia Group (PALG) Registry
Authors: Joanna Gora Tybor, Aleksandra Golos, Tomasz Sacha, Krzysztof Lewandowski, Joanna Niesiobedzka-Krezel, Maria Bieniaszewska, Hubert Wysoglad, Olga Grzybowska-Izydorczyk, Ilona Seferynska, Marta Sobas, Maria Czyżewska, Agnieszka Michalska, Waldemar Sawicki, Malwina Mazur, Marek Hus, Ewa Bodzenta, Magdalena Olszewska-Szopa, Elżbieta Patkowska, Wojciech Świstek, Krzysztof Jamroziak
Journal: Blood (2019)
Integration of Genetic, Transcriptomic, and Immune Profiles Reveals Genomically-Distinct Populations in Low-Grade Lymphomas
Authors: Keenan T. Hartert, Kerstin Wenzl, Jordan Krull, Michelle Manske, Vivekananda Sarangi, Melissa C Larson, Theodora Anagnostou, Ellen D. McPhail, Brian K. Link, Stephen M Ansell, James R. Cerhan, Dragan Jevremovic, Anne J Novak
Journal: Blood (2019)
The Guillain-Barrù Syndrome
Authors: Robert E. Crozier, Allan B. Ainley
Journal: New England Journal of Medicine (1955)

PROMPTED by the apparently increasing interest in the Guillain—Barré syndrome, judging from the literature, we consider it appropriate to review 17 cases of this clinical complex observed at Grasslands Hospital between 1946 and 1953. Of these patients 3 died, and the pertinent autopsy findings are reviewed.Etiology and PathogenesisSince 1859, when Landry made what was probably the first description of this condition, few factual data have come forth to dispel the obscurity surrounding its cause. Specific toxins, viruses and bacteria, as well as dietary deficiencies, heavy-metal poisoning and circulatory disturbances, have been blamed. This symptom complex has been reported . . .
Waldenström Macroglobulinemia in Young Patients Treated in the Modern Era: A Multi-Institutional Italian Study
Authors: Marzia Varettoni, Angela Ferrari, Alessandra Tedeschi, Virginia Valeria Ferretti, Rita Rizzi, Marina Motta, Francesco Piazza, Michele Merli, Giulia Benevolo, Carlo Visco, Luca Laurenti, Vittorio Del Fabro, Antonio Abbadessa, Catherine Klersy, Sara Rattotti, Marina Deodato, Corinna Greco, Andrea Corbingi, Stefano Luminari, Luca Arcaini
Journal: Blood (2019)
A Phase 1b Study Evaluating the Safety and Efficacy of Topical Administration of WP1220, an Inhibitor of STAT3 Activation, in Stage I, II or III Mycosis Fungoides (MF)
Authors: Malgorzata Sokołowska-Wojdyło, Izabela Blazewicz, Berenika Olszweska, Ewa Maria Zak, Walter Klemp, Sandra L Silberman, Waldemar Priebe
Journal: Blood (2019)
NIMG-63. LONGITUDINAL ANALYSIS OF OLIGODENDROGLIOMA GROWTH PATTERN REVEALED SPATIAL HETEROGENEITY AND DIVERSE TREATMENT RESPONSE
Authors: Dieter Heiland, Robin Ohle, Simon Behringer, Juergen Beck, Oliver Schnell
Journal: Neuro-Oncology (2019)

Abstract Oligodendroglioma are defined by a distinct molecular phenotype marked by 1p19q co-deletion and simultaneous presence of an IDH1/2 mutation. These tumors showed a favorable clinical course and long-term survival of around 15 years. Due to the long course of the disease, prospective studies to determine the effectiveness of different therapeutic strategies are difficult, since the percentage of patients with multiple therapies is high. Here we report a computational approach to map the longitudinal growth pattern, to quantify the effect of therapies on tumor growth and to identify similarities and spatial heterogeneity of oligodendroglioma growth. In our study, we included a cohort of 44 histopathologically and molecularly stratified oligodendrogliomas WHO°II (n=23) and WHO°III (n=21). We started our investigation with the longitudinal tumor segmentation. All volumetric data were pinpointed to the times of tumor therapy within all patients. Next, we extracted first-order features of tumor growth and response to chemo- or radiotherapy as well as resection, resulting in a total number of 98 features. An unsupervised cluster was used to identify similarities between patients, which revealed 3 subgroups. The first subgroup contained patients with predominantly frontal oligodendrogliomas marked by increased response to radiotherapy. The second subgroup included temporal oligodendrogliomas with high response rate to PC/PCV chemotherapy and flagged by epilepsy. The third group was heterogeneous with varying growth behaviors. A survival analysis showed a better separation between low- and high-risk patients based on the growth pattern model, in contrast to the WHO grading system. Taken together, our analysis revealed a novel classification of oligodendroglioma based on the longitudinal growth pattern and therapeutical response. We also detected a spatial difference between frontally or temporally localized oligodendrogliomas. We plan to further investigate molecular data that explain these spatial differences, which also may uncover novel therapeutic strategies.
Neuroendocrine Tumors—Less Well Known, Often Misunderstood, and Rapidly Growing in Incidence
Authors: Aman Chauhan, Elise Kohn, Jaydira Del Rivero
Journal: JAMA Oncology (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
High Natural Killer Cell Count at Diagnosis Predicts a Good Response to Immunosuppressive Therapy in Aplastic Anemia
Authors: Atsushi Narita, Hideki Muramatsu, Yinyan Xu, Motoharu Hamada, Daisuke Ichikawa, Eri Nishikawa, Nozomu Kawashima, Yusuke Okuno, Nobuhiro Nishio, Hirohito Yamazaki, Shinji Nakao, Seiji Kojima, Yoshiyuki Takahashi
Journal: Blood (2019)
Ectopic pregnancy and miscarriage: diagnosis and initial management: summary of updated NICE guidance
Authors: Katie Webster, Hilary Eadon, Sarah Fishburn, Geeta Kumar
Journal: BMJ (2019)

### What you need to know

Miscarriage and ectopic pregnancy have an adverse effect on the quality of life of many women, with early pregnancy loss accounting for over 50 000 hospital admissions in the UK annually.1 Ectopic pregnancy (where the pregnancy implants outside the endometrial cavity, most commonly within the fallopian tube) occurs in approximately 11 per 1000 pregnancies.2 Unfortunately, women still die during early pregnancy, with four maternal deaths reported in the UK between 2013 and 2015.3 However, the case fatality rate has decreased over recent years,2 suggesting that earlier diagnosis and treatment has made an impact. Accurate diagnosis and effective management of early pregnancy loss is therefore vital to avoid women dying unnecessarily, and to reduce the incidence of associated physical and psychological morbidity.

This article summarises the updated recommendations from the National Institute for Health and Care Excellence (NICE) on the diagnosis and management of tubal ectopic pregnancy and miscarriage in early pregnancy (up to 13 completed weeks of pregnancy).4

In addition to these updated recommendations, the guideline also contains recommendations on providing …
The Lost or Absence of MRD&lt;0.1% at Any Time after 2 Cycles of Consolidation Chemotherapy in CBFB-MYH11-Positive Acute Myeloid Leukemia Indicates Poor Prognosis
Authors: Wenbing Duan, Jinsong Jia, Jing Wang, Xiaohong Liu, Lizhong Gong, Qian Jiang, Ting Zhao, Yu Wang, Xiaohui Zhang, Lanping Xu, Yanrong Liu, Yazhen Qin, Xiaojun Huang, Hao Jiang
Journal: Blood (2019)
Inhibition of mTOR Signaling Enhances Maturation of Cardiomyocytes Derived From Human-Induced Pluripotent Stem Cells via p53-Induced Quiescence
Authors: Jessica C. Garbern, Aharon Helman, Rebecca Sereda, Mohsen Sarikhani, Aishah Ahmed, Gabriela O. Escalante, Roza Ogurlu, Sean L. Kim, John F. Zimmerman, Alexander Cho, Luke MacQueen, Vassilios J. Bezzerides, Kevin Kit Parker, Douglas A. Melton, Richard T. Lee
Journal: Circulation (2019)

Current differentiation protocols to produce cardiomyocytes from human induced pluripotent stem cells (iPSCs) are capable of generating highly pure cardiomyocyte populations as determined by expression of cardiac troponin T. However, these cardiomyocytes remain immature, more closely resembling the fetal state, with a lower maximum contractile force, slower upstroke velocity, and immature mitochondrial function compared with adult cardiomyocytes. Immaturity of iPSC-derived cardiomyocytes may be a significant barrier to clinical translation of cardiomyocyte cell therapies for heart disease. During development, cardiomyocytes undergo a shift from a proliferative state in the fetus to a more mature but quiescent state after birth. The mechanistic target of rapamycin (mTOR)-signaling pathway plays a key role in nutrient sensing and growth. We hypothesized that transient inhibition of the mTOR-signaling pathway could lead cardiomyocytes to a quiescent state and enhance cardiomyocyte maturation.Cardiomyocytes were differentiated from 3 human iPSC lines using small molecules to modulate the Wnt pathway. Torin1 (0 to 200 nmol/L) was used to inhibit the mTOR pathway at various time points. We quantified contractile, metabolic, and electrophysiological properties of matured iPSC-derived cardiomyocytes. We utilized the small molecule inhibitor, pifithrin-α, to inhibit p53 signaling, and nutlin-3a, a small molecule inhibitor of MDM2 (mouse double minute 2 homolog) to upregulate and increase activation of p53.Torin1 (200 nmol/L) increased the percentage of quiescent cells (G0 phase) from 24% to 48% compared with vehicle control (P<0.05). Torin1 significantly increased expression of selected sarcomere proteins (including TNNI3 [troponin I, cardiac muscle]) and ion channels (including Kir2.1) in a dose-dependent manner when Torin1 was initiated after onset of cardiomyocyte beating. Torin1-treated cells had an increased relative maximum force of contraction, increased maximum oxygen consumption rate, decreased peak rise time, and increased downstroke velocity. Torin1 treatment increased protein expression of p53, and these effects were inhibited by pifithrin-α. In contrast, nutlin-3a independently upregulated p53, led to an increase in TNNI3 expression and worked synergistically with Torin1 to further increase expression of both p53 and TNNI3.Transient treatment of human iPSC-derived cardiomyocytes with Torin1 shifts cells to a quiescent state and enhances cardiomyocyte maturity.
Flow Cytometric Immunophenotyping Distinguishes Lymphoplasmacytic Lymphoma from Marginal Zone Lymphoma
Authors: Shi Hui Clarice Choong, Wee-Joo Chng, Sanjay De Mel, Te-Chih Liu, Bei Jenny Li, Li Mei Michelle Poon, Shir Ying Lee, Hoon Chung Tae, Rebecca Teng, Seok Wei Stephrene Chan
Journal: Blood (2019)
A Phase I Study of CC-90002, a Monoclonal Antibody Targeting CD47, in Patients with Relapsed and/or Refractory (R/R) Acute Myeloid Leukemia (AML) and High-Risk Myelodysplastic Syndromes (MDS): Final Results
Authors: Amer M. Zeidan, Daniel J. DeAngelo, Jeanne M. Palmer, Christopher S. Seet, Martin S. Tallman, Xin Wei, Ying Fei Li, Nanette Hock, Michael R. Burgess, Kristen Hege, Wendy Stock
Journal: Blood (2019)
Molecular characterization of highly tumorigenic cell lines used in a xenograph model to investigate cellular therapy for the treatment of refractory ovarian cancer
Authors: S. B. Ingersoll, P. Yue, S. Ahmad, J. Turkson, J. R. Edwards, R. W. Holloway
Journal: Journal of Clinical Oncology (2009)

e16516 Background: Because current therapies for ovarian cancer (OC) have little impact on the long-term survival, there is a compelling need to develop innovative strategies. Our aim was to characterize OC cell lines which can be utilized to test cellular therapy in combination with cytokines or chemotherapies to elicit a graph versus tumor response to treat refractory OC patients. Methods: SKOV-3-RFP, a red fluorescent protein (RFP) expressing line, was passaged through nude mice to create more tumorigenic lines compared to parental SKOV-3 cells. Three SKOV-3-derived lines were established and characterized for IFNα-2b sensitivity, E-cadherinand CCN1gene expression, and STAT3 activation. The cells were grown in the presence of IFNα-2b to determine proliferative effects. Tumors were harvested when mice became moribund; ascitic fluid (AF) and solid tumor (ST) tissue were snap-frozen. Expression of E-cadherinand CCN1, which have been implicated to play role(s) in OC pathobiology, were analyzed in ST harvested from the mice and from SKOV3-derived lines (SKOV3-RFP, AF1, AF2, and AF3). We investigated the activation status in the SKOV3-derived cells of STAT3, which has been associated with malignant transformation and tumor progression. Results: Parental SKOV3-RFP cells when injected at a dose of 5x10 6 gave a tumor incidence of 4/6 in 14 weeks. AF1 and AF2, when injected at a dose of 1x10 6 resulted in 100% tumor incidence in 5-weeks (n = 5). These two lines were also more resistant to IFNα-2b compared to RFP. All SKOV3-derived lines and ST expressed E-cadherin by RT-PCR. None of the SKOV3-derived lines expressed CCN1; however, one of the two AF1 ST tested expressed CCN1. Both AF2 ST evaluated showed weak expression of CCN1. In vitro DNA-binding with electrophoretic mobility shift assay (EMSA), showed AF1 and AF3 cells harbor constitutively-active STAT3, whereas the RFP line does not. Conclusions: The SKOV3-derived lines that we developed will be a better model to test novel OC treatment regiments because these lines exhibit increased resistance to IFNα-2b, are more tumorigenic in a xenograph model, show aberrant STAT3 activation, and tumors harvested from these lines express genes that make these lines more aggressive. No significant financial relationships to disclose.