tbuckley/cabot-search huggingface dataset:
AB0280 Gender-differences in cardio-vascular risk factors in patients with inflammatory rmds
Authors: N. Marinez Alberola, C. Fernandez-Carballido, R. Martin Domenech, T. Pedraz Penalva, G. Albert Espi, F. Sivera Mascaró
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and spondyloarthritis (SpA) have an increased risk of cardiovascular events when compared to the general population. This increase is probably due to both the deleterious effects of inflammation and the traditional cardio-vascular risk factors (CVRF). <h3>Objectives</h3> Analyse the differences by gender in the distribution of traditional CVRF in patients with chronic arthritis included in a screening program. <h3>Methods</h3> A program for the detection and management of traditional CVRF in patients with chronic arthritis was implemented following EULAR recommendations. Patients with RA, PsA and SpA followed-up at our department were included in this program. Patients underwent a baseline visit in a nurse-clinic where cardiovascular (CV) risk was assessed. Data on smoking status, diet, exercise, diagnosis of hypertension (HT), diabetes mellitus (DM), hypercholesterolemia (HCh) and prior CV events. The height and weight, the abdominal perimeter and the blood pressure of patients were measured. Results of a blood test previously ordered by the managing physician was recorded. SCORE index was calculated as applied to Spanish population and then modified according to EULAR recommendations. Treatment targets (previously agreed upon by the department of rheumatology) were set; if pharmacological treatment was needed, patients were referred to their rheumatologist or GP. Data are presented of all patients included in this screening program. <h3>Results</h3> The number of patients assessed at the nurse-led clinic for CVRF assessment and with data on gender, is 416. In the table 1 we present the characteristics of these patients grouped by gender <h3>Conclusions</h3> In a similar manner as the general population, there is a greater number of CV events in men than in women. However, the gender-distribution of traditional CVRF is similar except for DM, more common in men. <h3>Disclosure of Interest</h3> None declared
Outcome of Children With Hypodiploid Acute Lymphoblastic Leukemia: A Retrospective Multinational Study
Authors: Ching-Hon Pui, Paola Rebora, Martin Schrappe, Andishe Attarbaschi, Andre Baruchel, Giuseppe Basso, Hélène Cavé, Sarah Elitzur, Katsuyoshi Koh, Hsi-Che Liu, Kajsa Paulsson, Rob Pieters, Lewis B. Silverman, Jan Stary, Ajay Vora, Allen Yeoh, Christine J. Harrison, Maria Grazia Valsecchi
Journal: Journal of Clinical Oncology (2019)

PURPOSE We determined the prognostic factors and utility of allogeneic hematopoietic cell transplantation among children with newly diagnosed hypodiploid acute lymphoblastic leukemia (ALL) treated in contemporary clinical trials. PATIENTS AND METHODS This retrospective study collected data on 306 patients with hypodiploid ALL who were enrolled in the protocols of 16 cooperative study groups or institutions between 1997 and 2013. The clinical and biologic characteristics, early therapeutic responses as determined by minimal residual disease (MRD) assessment, treatment with or without MRD-stratified protocols, and allogeneic transplantation were analyzed for their impact on outcome. RESULTS With a median follow-up of 6.6 years, the 5-year event-free survival rate was 55.1% (95% CI, 49.3% to 61.5%), and the 5-year overall survival rate was 61.2% (95% CI, 55.5% to 67.4%) for the 272 evaluable patients. Negative MRD at the end of remission induction, high hypodiploidy with 44 chromosomes, and treatment in MRD-stratified protocols were associated with a favorable prognosis, with a 5-year event-free survival rate of 75% (95% CI, 66.0% to 85.0%), 74% (95% CI, 61.0% to 89.0%), and 62% (95% CI, 55.0% to 69.0%), respectively. After exclusion of patients with high hypodiploidy with 44 chromosomes and adjustment for waiting time to transplantation and for covariables in a Poisson model, disease-free survival did not differ significantly ( P = .16) between the 42 patients who underwent transplantation and the 186 patients who received chemotherapy only, with an estimated 5-year survival rate of 59% (95% CI, 46.5% to 75.0%) versus 51.5% (95% CI, 44.7% to 59.4%), respectively. Transplantation produced no significant impact on outcome compared with chemotherapy alone, especially among the subgroup of patients who achieved a negative MRD status upon completion of remission induction. CONCLUSION MRD-stratified treatments improved the outcome for children with hypodiploid ALL. Allogeneic transplantation did not significantly improve outcome overall and, in particular, for patients who achieved MRD-negative status after induction.
AB0662 Subglottic stenosis in granulomatosis with poliangiitis
Authors: C.E. Pena, F. Giordano, L. Garcia, C. Costi, G. Pendon, A. Vulcano, D. Pereira, M. Garcia
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> The characteristic lesion of laryngotracheal involvement in granulomatosis with polyangiitis (GPA) is subglottic stenosis (SGS), due to active disease or from chronic recurrent inflammation, 8% to 23% during the course of GPA and as initial manifestation in 1% to 6% of cases. <h3>Objectives</h3> Describe clinical features and treatment of patients with SGS <h3>Methods</h3> We retrospectively reviewed the medical records of 46 patients with SGS due to GPA diagnosed at a Rheumatology department (2000–2017). We retrospectively reviewed the medical records of 46 patients with SGS due to GPA diagnosed at a Rheumatology department (2000–2017). <h3>Results</h3> 6/46 patients with GPA diagnosis presented SGS (13%). 83% women, mean age of 37.8 years (DS ±14.8). Mean time between the presentation of the GPA and the diagnosis of SGS:18 months. Most frequent clinical manifestations of SGS: dyspnea (83%), stridor (83%), dysphonia (50%), cough (33%), bronchospasm (16%). One patient presented SGS as initial manifestation of the disease. Mean BVAS:14. Two patients presented such complication with evidence of systemic manifestations. Re stenosis was observed in one patient. Treatment: IV CYC 83%, oral CYC 16%, methylprednisolone (MP) 83%, oral steroids, plasma exchange (16%) in each one. Endoscopic intervention and balloon dilatation33%, and intralesional Mitomycin 16%. <h3>Conclusions</h3> 13% patients with GPA presented SGS, being in the majority of cases associated with other manifestations of the disease. However, 67%had no signs of systemic involvement (localised disease). Local treatment was necessary in only 33% because there was a good response to IS in 67% of the cases. <h3>Reference</h3> [1] G. Horta-Baas, et al. Subglottic stenosis in granulomatosis with polyangiitis (Wegener's granulomatosis): Report of 4 cases.Reumatol Clin. 2016;12(5):267–273. (Surgical interventions and local therapy for Wegener's granulomato) <h3>Disclosure of Interest</h3> None declared
Spirit 2: Final 5 Year Analysis of the UK National Cancer Research Institute Randomized Study Comparing Imatinib with Dasatinib in Patients with Newly Diagnosed Chronic Phase CML
Authors: Stephen O'Brien, Leanne Cork, Valeria Bandeira, Ruth Bescoby, Letizia Foroni, Lynn Alaily, Wendy Osborne, Helen Bell-Gorrod, Nicholas Latimer, Jane Apperley, Corinne Hedgley, Richard Syzdlo, Jennifer Byrne, Christopher Pocock, Bernard Ramsahoye, Thomas Zwingers, James Wason, Mhairi Copland, Richard Clark
Journal: Blood (2018)
Abstract 268: A Convolutional Neural Network for Real-Time Discrimination of Shock-Indicated Rhythms During CPR
Authors: Tetsuo Hatanaka, Hiroshi Kaneko, Aki Nagase, Seishiro Marukawa
Journal: Circulation (2018)

Introduction: An interruption of chest compressions during CPR adversely affects patient outcome. Currently, however, periodical interruptions are unavoidable to assess the ECG rhythms and to give shocks for defibrillation if indicated. Evidence suggests a 5-second interruption immediately before shocks may translate into ~15% reduction of the chance of survival. The objective of this study was to build, train and validate a convolutional neural network (artificial intelligence) for detecting shock-indicated rhythms out of ECG signals corrupted with chest compression artifacts during CPR. Methods: Our convolutional neural network consisted of 7 convolutional layers, 3 pooling layers and 3 fully-connected layers for binary classification (shock-indicated vs non-shock-indicated). The input data set was a spectrogram consisting of 56 frequency-bins by 80 time-segments transformed from a 12.16-seconds ECG signal. From AEDs used for 236 patients with out-of-hospital cardiac arrest, 1,223 annotated ECG strips were extracted. Ventricular fibrillation and wide-QRS ventricular tachycardia with HR&gt;180 beats/min were annotated as shock-indicated, and the others as non-shock-indicated. The total length of the strips was 8:49:57 (hr:min:sec) and 8:02:07 respectively for shock-indicated and non-shock-indicated rhythms. Those strips were converted into 465,102 spectrograms allowing partial overlaps and were fed into the neural network for training. The validation data set was obtained from a separate group of 225 patients, from which annotated ECG strips (total duration of 62:11:28) were extracted, yielding 43,800 spectrograms. Results: After the training, both the sensitivity and specificity of detecting shock-indicated rhythms over the training data set were 99.7% - 100% (varying with training instances). The sensitivity and specificity over the validation data set were 99.3% - 99.7% and 99.3% - 99.5%, respectively. Conclusions: The convolutional neural network has accurately and continuously evaluated the ECG rhythms during CPR, potentially obviating the need for rhythm checks for defibrillation during CPR.
THU0328 Mir-499 polymorphism is associated with susceptibility to psoriatic arthritis – preliminary study
Authors: R. Sokolik, J. Swierkot, M. Iwaszko, M. Kozlowski, L. Korman, P. Wiland, K. Bogunia-Kubik
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Polymorphism within the miR-499 has been reported to be associated with susceptibility to rheumatoid arthritis (RA) in various populations. <h3>Objectives</h3> Our study aimed to find out whether similar association could be observed also in Polish population in both RA and psoriatic arthritis (PsA) patients. <h3>Methods</h3> For this purpose 359 individuals were studied, including 111 RA patients, 86 patients with PsA and 162 healthy blood donors that served as a control group. Genotyping for miR-499 rs3746444 T/C was performed using a LightSNiP assay. <h3>Results</h3> Distribution of the miRNA-499 alleles and genotypes was similar in RA patients and controls. Among RA patients those carrying the CC homozygous genotype presented with lower DAS28 at diagnosis (0.027) but higher CRP levels after 12 weeks of anti-TNF treatment (p=0.042). Interestingly, the TT genotype (rs3746444) was overexpressed in patients with PsA as compared to controls (OR=1.85, p=0.034) but its frequency was not significantly different when compared to RA cases. This polymorphism was also not found to be associated with clinical parameters in PsA patients. <h3>Conclusions</h3> These results show that miR-499 rs3746444 T/C polymorphism may constitute a risk factor for psoriatic arthritis development. <h3>Acknowledgements</h3> This work was supported by the NCN 2016/21/B/NZ5/01901 project. <h3>Disclosure of Interest</h3> None declared
Abstract 15764: Validation of Non-Invasive MRI-based Assessment of Central Blood Pressure in a Population of Repaired Coarctation Patients
Authors: Arna van Engelen, Jorge Mariscal Harana, Torben Schneider, Mateusz Florkow, Peter Charlton, Bram Ruijsink, Hubrecht de Bliek, Israel Valverde, Marietta Charakida, Kuberan Pushparajah, Rene Botnar, Jordi Alastruey
Journal: Circulation (2017)

Introduction: Central blood pressure (CBP) is a highly prognostic cardiovascular risk factor. It can be accurately assessed invasively with catheterization, however, this is costly and has associat...
SAT0416 Life-threatening primary sjÖgren syndrome: clinical characterisation and outcomes in 1535 patients (GEAS-SS REGISTRY)
Authors: S. Retamozo, A. Flores-Chávez, B. Kostov, R. Solans, G. Fraile, B. Maure, C. Feijoo, F.J. Rascón, R. Pérez-Alvarez, M. Zamora, A. García-Pérez, M. Lopez-Dupla, M.Á. Duarte Millán, M. Ripoll, E. Fonseca, P. Guisado-Vasco, B. Pinilla, G. de la Red, S. Rodríguez Rodríguez, M.J. Soto-Cárdenas, P. Fanlo, C. Morcillo, M. Ramos-Casals, P. Brito-Zerón
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Objectives</h3> To analyse the clinical features and outcomes of patients presenting with life-threatening systemic disease in a large cohort of Spanish patients with primary Sjogren syndrome (SjS). <h3>Methods</h3> The GEAS-SS multicenter registry was formed in 2005 with the aim of collecting a large series of Spanish patients with primary SS. By January 2018, the database included 1535 consecutive patients fulfilling the 2002/2016 criteria. Life-threatening systemic disease was defined as an activity level scored as “High” in at least one ESSDAI domain. <h3>Results</h3> 209 (14%) were classified as presenting with a life-threatening systemic disease: 194 presented one ESSDAI domain classified as high, 14 two domains and only one presented three high activity domains. The high-ESSDAI domains included lymphadenopathy in 78 (37%) cases, CNS in 28 (13%), PNS in 25 (12%), pulmonary in 25 (12%), renal in 22 (10%), cutaneous in 18 (9%), articular in 18 (9%), haematological in 7 (3%) and muscular in 4 (2%); the most frequent clinical presentations in each domain were, respectively, parotid lymphoma (n=41), focal neurological deficit (n=20), ganglionopathy (n=11), usual interstitial pneumonitis (n=9), renal failure (n=11), ulcerated cutaneous vasculitis (n=9), symmetric polyarthritis (m=17), severe thrombocytopenia (n=3) and severe myositis (n=3). With respect to therapeutic approach, 144 (69%) required glucocorticoids, 65 (31%) immunosuppressive agents and 42 (20%) biological therapies. During the follow-up, 36 (17%) patients died, mainly due to lymphoma (n=16), pulmonary fibrosis (n=5), end-stage renal failure (n=4), CNS progressive disease (n=3) and systemic vasculitis (n=3). <h3>Conclusions</h3> A 14% of patients with primary SjS develop a potentially life-threatening systemic disease (mainly lymphoma, but also severe internal organ involvements including nervous system, the lungs and the kidneys). This subset of patients requires intensive therapeutic management with a mortality rate of nearly 20% of cases. <h3>Disclosure of Interest</h3> None declared
THU0279 Gender difference in psychological status and sleep quality in the patients with ankylosing spondylitis
Authors: Y. Jiang, Q. Lv, J. Qi, D. Huang, X. Zhang, M. Yang, Y. Zhang, J. Gu
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Ankylosing spondylitis (AS) is a chronic inflammatory disease which mainly involves the spine and sacroiliac joints. Anxiety and depression, are common among people with arthritis and interplay independently and synergistically with clinical outcomes such as pain and disability.<sup><sup>1</sup></sup> Psychological variables can be found either within the body functions or within the personal factors.<sup><sup>2</sup></sup> Meanwhile, AS patients may suffer from various sleep problems. Pain intensity, anxiety, and depression correlated significantly with poorer sleep quality.<sup><sup>3</sup></sup> Whether gender difference exists in psychological status and sleep disturbance in AS patients remains unknown. <h3>Objectives</h3> Our aim was to investigate the prevalence of psychological disorders and sleep disturbance in Chinese patients with AS and then to explore gender difference in psychological status and sleep quality in the patients with AS. <h3>Methods</h3> Patients fulfilling modified New York criteria were enrolled from several rheumatology centres in China. Participants were required to complete a set of questionnaires and examinations, including demographic and clinical information, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), Zung self-rating anxiety scale (SAS), Zung self-rating depression scale (SDS) and the Pittsburgh Sleep Quality Index questionnaire (PSQI). Independent T test was performed to compare patients with different gender. <h3>Results</h3> Totally 3117 patients were included in the study. 2501 were males, and mean age were 27.20±9.13 years. While 616 were female patients' whose mean age were 28.84±9.21 years. 32.3% of the patients had anxiety. 62.2% had depression according to SDS. 63.4% had sleep disturbance. Male patients had an earlier age of disease onset than females (p&lt;0.01). Although female patients had a shorter disease duration, they had higher scores of SAS and SDS (p&lt;0.05). There was no significant difference in sleep quality between male and female patients. <h3>Conclusions</h3> A large number of AS patients were found to have anxiety, depression, sleep disturbance. Male AS patients tend to have an earlier age of disease onset, while female patients are more likely to have psychological disorders. Clinicians should take these factors into account during the assessment of the patients. <h3>References</h3> [1] McWilliams L A, Cox BJ and Enns MW. Mood and anxiety disorders associated with chronic pain: an examination in a nationally representative sample. PAIN2003;106:127–33. [2] Boonen A. Towards a better understanding of the role of psychological variables in arthritis outcome research. Arthritis Res Ther2010;12:106. [3] Sayar K, Arikan M, and Yontem T. Sleep quality in chronic pain patients. Can J Psychiatry2002;47:844–8. <h3>Disclosure of Interest</h3> None declared
AB0432 Biologic dmards treatment retention in patients with rheumatoid arthritis according to the moscow arthritis registry (MERA)
Authors: E. Koltsova, E. Zhilyaev, G. Lukina, E. Shmidt
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Retention on treatment is a good index of efficacy and safety of treatment used in the real clinical practice. These data may be useful to planning the treatment among some years.<sup>1 2</sup> <h3>Objectives</h3> To compare the drug survival of biological therapies. <h3>Methods</h3> We followed rheumatoid arthritis patients treated with biologics DMARD and registered in MERA 2012–January 2018. All patients had more than one visit in the registry. <h3>Results</h3> We analysed 799 patients (mean age 57,3±13, mean diseases duration 15,6±10,3 years). The average time until a change of treatment for infliximab was 399 days – the shortest treatment duration. Abatacept (median survival – 2922 days) demonstrated significant superiority over adalimumab (1339 days) (p&lt;0.001), infliximab (399 days) (p&lt;0.001), rituximab (2557 days) (p=0.004) and etanercept (1492 days) (p=0.035) when they was used as the first biologic drug. Among second-line therapy, the longest treatment survival has etanercept (3435 days), the shortest – infliximab (212 days). <h3>Conclusions</h3> The results of the trial show the differences in treatment survival of some biologics. It can be reasonable to take these significant differences into consideration by the long-term planning of the biologic treatment of rheumatoid arthritis patients. <h3>References</h3> [1] Virginia Martinez-Santana, et al. Comparison of drug survival rates for tumor necrosis factor antagonists in rheumatoid arthritis. Patient Prefer Adherence2013;7:719–727. [2] Du Pan SM. Arthritis Rheum. Comparison of drug retention rates and causes of drug discontinuation between anti-tumor necrosis factor agents in rheumatoid arthritis2009. <h3>Disclosure of Interest</h3> None declared
AB1238 The self-management model in the agenda of successive consultations in rheumatology
Authors: D. Castro Corredor
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> The rheumatology service of Ciudad Real Hospital, located in an autonomous community of that same name that is nearly in the centre of Spain, implemented a self-management model of successive appointments more than 10 years ago. Since then, the physicians of the department schedule follow-up visits for their patients depending on the disease, its course and ancillary tests. <h3>Objectives</h3> The purpose of this study is to evaluate and compare the self-management model for successive appointments in the rheumatology service of Ciudad Real Hospital versus the model of external appointment management implemented in 8 of the hospital's 15 medical services. <h3>Methods</h3> A comparative and multivariate analysis was performed to identify variables with statistically significant differences, in terms of activity and/or performance indicators and quality perceived by users. The comparison involved the self-management model for successive appointments employed in the rheumatology service of Ciudad Real Hospital and the model for external appointment management used in 8 hospital medical services between January 1 and May 31, 2016. <h3>Results</h3> In a database with more than 1 00 000 records of appointments involving the set of services included in the study, the mean waiting time and the numbers of non-appearances and rescheduling of follow-up visits in the rheumatology department were significantly lower than in the other services. The number of individuals treated in outpatient rheumatology services was 7,768, and a total of 280 patients were surveyed (response rate 63.21%). They showed great overall satisfaction, and the incidence rate of claims was low. <h3>Conclusions</h3> Our results show that the self-management model of scheduling appointments has better results in terms of activity indicators and in quality perceived by users, despite the intense activity. Thus, this study could be fundamental for decision making in the management of health care organisations. <h3>References</h3> [1] Pérez JJ, García J, Tejedor M. Gestión clínica: conceptos y metodología de implantación. Rev Calidad Asistencial. 2002;17:305–11. [2] Anguita-Guimet A, Ortiz-Molina J, Sitjar-Martínez de Sas S, Sisó-Almirall A, Menacho-Pascual I, Sebastián-Montal L. Nuevo modelo de autogestión profesional en atención primaria. Semergen. 2012;38:79–86, http://dx.doi.org/10.1016/j.semerg.2011.07.003. <h3>Acknowledgements</h3> The authors want to express their gratitude to all the services involved in this study, since without their collaboration all this would not have been possible at the time of the collection, categorization and analysis of data, as well as the interpretation of these and the application in a the near future for a better organisation of the health system. <h3>Disclosure of Interest</h3> None declared