tbuckley/cabot-search huggingface dataset:
Hypofractionated therapy versus conventional fractionated radiotherapy in elderly patients with glioblastoma multiforme
Authors: H. Elshenshawy, A. Abd El-Razek, H. Bader
Journal: Journal of Clinical Oncology (2007)

12529 Background: To evaluate efficacy of short- course radiotherapy(RT) in elderly (&gt;60years) patients with glioblastoma multiforme(GBM), and compare this biological similar short -course radiotherapy with a standard radiotherapy Methods: Forty-four elderly patients with GBM were randomly assigned after surgery to receive either a short-course of radiotherapy (45 Gy in 15 fractions over 3 weeks ) or standard radiotherapy (60 Gy in 30 fractions over 6weeks) to a target volume described as tumor visible on CT scan and a 2- cm margin . The primary end point was overall survival. Results: The overall response rate and median duration of response were 60%and 8.5 months in short- course RT versus 65% and 8 months in standard RT . Improvement in pretreatment performance status and increase in post- treatment corticosteroid dosage were observed in 50% and 25% in short- course RT versus 40% and 50% in standard RT (P=0.09, P=0.031) respectively. Median survival time was 5.9 months in short-course RT versus 5.6 months in standard RT . Six months, 1-year survival and progression-free survival rates were 40%, 15% and 30% ,10% in short- course RT versus 45%, 10% and 35% , 5% in standard RT , respectively. In both treatment groups, females did significantly better than males, patients with KPS 60–70 did significantly better than those with KPS 50 , patients having tumors 4–5 cm did significantly better than those with tumors 6–8 cm as well as did those with more radical surgery when compared to those with biopsy only. On multivariate analysis , only tumor size and extent of surgery were found to independently influence survival. Acute toxicity was generally assessed as mild in the two treatment groups. While RT -induced brain necrosis appeared only in one patient received short- course RT, but this patient died from tumor recurrence. Conclusions: Hypofractionated RT is feasible and safe treatment for elderly patients with GBM. No significant financial relationships to disclose.
Abstract P118: The Ongoing Experience of Cardiovascular Risk Assessment Implementation in Primary Care of the CUORE Project
Authors: Luigi Palmieri, Serena Vannucchi, Cinzia Lo Noce, Anna Di Lonardo, Daniela Minutoli, Brigid Unim, Tiziana Grisetti, Claudia Meduri, Chiara Donfrancesco
Journal: Circulation (2020)

Background: The Italian National Prevention Plan 2005-2008 included a 10-year cardiovascular risk assessment (10-CR) for the general population aged 35-69 years using the CUORE-Project risk score. GPs were encouraged to collect data on risk factors, perform a 10-CR and send data to the Cardiovascular Risk Observatory (CRO). Aim: The aim of this study is to show updated data of the ongoing surveillance system of the 10-CR in the Italian adult population, a first step to implement primary preventive actions at individual level. Methods: A training plan for GPs was launched by the Ministry of Health. Data were collected using the cuore.exe software, easily and freely downloadable by GPs from the CUORE-Project website (www.cuore.iss.it). The CRO provides a web-platform to analyze and compare data on 10-CR and risk factors at both regional and national level. In the subgroup of persons examined at least twice a year, variations in continuous risk factors mean levels and categorical risk factors prevalence between baseline and follow-up and their 95% confidence intervals (C.I.) were calculated using methods for matched pair samples. Results: By October 2019, about 3,500 GPs downloaded cuore.exe ; about 300,000 CR assessments on about 140,000 persons were sent to CRO. CR mean was 3.1% in women, 8.5% in men; 28% of men and 64% of women were at lower risk (CR&lt;3%), 9.9% of men and 0.4% of women were at high risk (CR≥20%). Twenty-six percent of men and 16% of women were current smokers, 13% of men and 10% of women were diabetic, and 33% of hypertensive men and 35% of hypertensive women were under specific treatment. Among those with at least two risk assessments (31% of the sample), 11% shifted to a lower risk class after one year (14 of men and 7% of women respectively). Systolic blood pressure mean levels decreased by 0.6 mmHg (95%-C.I. 0.3-0.8 mmHg), diastolic blood pressure by 0.5 mmHg (95%-C.I. 0.2-0.7 mmHg), total cholesterol level by 3.1% (95%-C.I. 2.3%-4.0%)6.6 mg/dl6; HDL-cholesterol increased in women by 0.3 mg/dl (95%-C.I. 0.1-0.5 mg/dl). Conclusions: Data demonstrate that 10-CR assessment can be an effective first step to implement preventive actions in primary care. The individual risk score is becoming a useful tool for GPs to assess their patients’ CR and promote primary prevention by focusing attention on the adoption of healthy lifestyles. These encouraging data can be used to support health policy decision processes.
Abstract 337: Cytoglobin Promotes Cardiac Stem Cell Survival Against Oxidative Stress via the Upregulation of the NFkB/iNOS Signal Pathway and Nitric Oxide Production
Authors: Shuning Zhang, Xiuchun Li, Frances L Jourd’heuil, Shunlin Qu, Neil Devijian, Edward Bennett, David Jourd’heuil, Chuanxi Cai
Journal: Circulation Research (2017)

Cardiac stem cells may serve in regenerative medicine to repair the infarcted heart. However, this approach is severely limited by the poor survival of donor cells. We previously showed that preconditioning human cardiac stem cells (hCSCs) with a nitric oxide (NO) donor enhanced cell survival through activation of survival signaling pathways. Recent studies suggest that the mammalian globin cytoglobin (CYGB) regulates NO metabolism and may regulate cell death. Therefore, the goal of the present study was to test the hypothesis that CYGB may serve important pro-survival functions in hCSCs. We found that CYGB is expressed in hCSCs, in the absence of any significant expression of myoglobin (MB), the primary hemoglobin expressed in adult cardiomyocytes. Through molecular approaches aimed at increasing or decreasing CYGB expression in hCSCs, we found that CYGB functions as a pro-survival factor in response to oxidative stress. This was associated with the upregulation of primary antioxidant systems such as peroxiredoxin 1 (PRDX1) and heme oxygenase-1 and anti-apoptotic factors, including BCL2, BCL-XL, and MCL1. Most significantly, we established that CYGB increased the expression of NFкB-dependent genes including iNOS (NOS2) and that iNOS-dependent NO production was required for a feedforward loop that maintains CYGB expression. Our study delineates for the first time a role for a globin in regulating hCSC survival and establishes novel mechanistic insights in the functional role of CYGB. It provides a rationale for the exploration of the CYGB pathway as a novel molecular target that can be used to enhance the effectiveness of stem cell therapy for ischemic heart disease.
Abstract 13202: QI-Focused Interventions Addressing Shared Decision-Making Practices for Patients with Heart Failure
Authors: Javed Butler, Alanna Morris, Nancy Albert, Robert Page, Cherilyn Heggen, Jeffrey D Carter, Laurence Greene, Tamar Sapir
Journal: Circulation (2018)

Introduction: Leading cardiology organizations have called for initiatives that engage patients with heart failure (HF) in shared decision-making (SDM). In a quality improvement (QI) program conduc...
The Synergic Association of hs-CRP and Serum Amyloid P Component in Predicting All-Cause Mortality in Patients With Type 2 Diabetes
Authors: Maria Giovanna Scarale, Massimiliano Copetti, Monia Garofolo, Andrea Fontana, Lucia Salvemini, Salvatore De Cosmo, Olga Lamacchia, Giuseppe Penno, Vincenzo Trischitta, Claudia Menzaghi
Journal: Diabetes Care (2020)

OBJECTIVE Type 2 diabetes is characterized by increased death rate. In order to tackle this dramatic event, it becomes essential to discover novel biomarkers capable of identifying high-risk patients to be exposed to more aggressive preventive and treatment strategies. hs-CRP and serum amyloid P component (SAP) are two acute-phase inflammation proteins, which interact physically and share structural and functional features. We investigated their combined role in associating with and improving prediction of mortality in type 2 diabetes. RESEARCH DESIGN AND METHODS Four cohorts comprising 2,499 patients with diabetes (643 all-cause deaths) were analyzed. The improvement of mortality prediction was addressed using two well-established prediction models, namely, EstimatioN oF mORtality risk in type 2 diabetiC patiEnts (ENFORCE) and Risk Equations for Complications of Type 2 Diabetes (RECODe). RESULTS Both hs-CRP and SAP were independently associated with all-cause mortality (hazard ratios [HRs] [95% CIs]: 1.46 [1.34–1.58] [P &amp;lt; 0.001] and 0.82 [0.76–0.89] [P &amp;lt; 0.001], respectively). Patients with SAP ≤33 mg/L were at increased risk of death versus those with SAP &amp;gt;33 mg/L only if hs-CRP was relatively high (&amp;gt;2 mg/L) (HR 1.96 [95% CI 1.52–2.54] [P &amp;lt; 0.001] and 1.20 [0.91–1.57] [P = 0.20] in hs-CRP &amp;gt;2 and ≤2 mg/L subgroups, respectively; hs-CRP-by-SAP strata interaction P &amp;lt; 0.001). The addition of hs-CRP and SAP significantly (all P &amp;lt; 0.05) improved several discrimination and reclassification measures of both ENFORCE and RECODe all-cause mortality prediction models. CONCLUSIONS In type 2 diabetes, hs-CRP and SAP show opposite and synergic associations with all-cause mortality. The use of both markers, possibly in combination with others yet to be unraveled, might improve the ability to predict the risk of death in the real-life setting.
Abstract P150: Association of Cholesterol Measures With Coronary Heart Disease Risk in Blacks and Whites in the Reasons for Geographic and Racial Differences in Stroke Study (regards)
Authors: Neil Zakai, Jessica Minnier, Monika M Safford, Lisandro Colantonio, Marguerite M Irvin, Sergio Fazio, Mary Cushman, Virginia J Howard, Nathalie Pamir
Journal: Circulation (2020)

Introduction: Abnormal plasma lipid levels associate with coronary heart disease (CHD) risk. Race interaction for these associations are not established. Hypothesis: We hypothesized that the association of HDL, LDL, and triglyceride with CHD is stronger in whites versus blacks. Methods: The REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort recruited 30,283 black and white individuals aged 45+ from the contiguous U.S. from 2003-7. Participants were followed until December 31, 2016 for CHD events (i.e., myocardial infarction or CHD death), participants with history of CHD at baseline were excluded. Cox regression models were used to assess the association between baseline lipids and incident CHD events adjusting for traditional cardiovascular risk factors. Results: With 23,894 participants (57.8% white and 58.4% female, mean age 64.11± 9.32), over a median 9.9 years of follow-up, 1,487 CHD events occurred (615 among blacks). Overall, higher total Cholesterol, LDL cholesterol, and triglycerides were associated with increased risk of CHD in both blacks and whites with no evidence of a race interaction (Table 1). For HDL, the point estimate was more protective in whites (HR 0.90) than in blacks (HR 0.98), but the interaction was non-significant (p=0.15). However, when HDL was stratified into clinical categories (&lt;40, 40-59, and ≥60), the reduction in point estimates was maintained among whites (HR 1.00, 0.88, and 0.74) but not among blacks (HR 1.00, 1.31, and 1.19) for HDL &lt;40, 40-59, and ≥60 respectively, p-interaction 0.01. Conclusion: Total cholesterol, LDL, and triglycerides predict CHD risk equally in blacks and whites in the REGARDS study, however there is heterogeneity in the protective effect by race, especially when traditional clinical categories are used. In whites, higher HDL is associated with reduced risk, whereas in blacks the association is not maintained. These findings suggest that HDL levels are a more viable metric for white than blacks to predict CHD risk.
IMPROVEMENT IN PATIENT CENTERED OUTCOMES FOLLOWING MITRAL VALVE SURGERY FOR SEVERE ISCHEMIC MITRAL REGURGITATION
Authors: Anuradha (Anu) Lala, Katherine Kirkwood, Alexander Iribarne, Alan Moskowitz, Jessica Overbey, Eric J. Charles, Daniel J. Goldstein, Patrick T. O’Gara, John Puskas, Emilia Bagiella, Wendy Taddei-Peters, Karen O'sullivan, Marissa Miller, Charles Laurin, Gennaro Giustino, Babatunde Yerokun, A. Gillinov, Annetine Gelijns, Michael Acker, Lynne Stevenson
Journal: Journal of the American College of Cardiology (2020)
GENDER AND RACE RELATED CARDIOVASCULAR MORBIDITY AND MORTALITY OF PATIENTS HOSPITALIZED WITH HIV
Authors: Omar Chehab, Mohit Pahuja, Rami Z. Morsi, Hussam Tabja, Jarret Weinberger, Diane Levine, Luis C. Afonso, Aiden Abidov
Journal: Journal of the American College of Cardiology (2020)
Sampling as a resource-rational constraint
Authors: Adam N. Sanborn, Jianqiao Zhu, Jake Spicer, Nick Chater
Journal: Behavioral and Brain Sciences (2020)

Abstract Resource rationality is useful for choosing between models with the same cognitive constraints but cannot settle fundamental disagreements about what those constraints are. We argue that sampling is an especially compelling constraint, as optimizing accumulation of evidence or hypotheses minimizes the cost of time, and there are well-established models for doing so which have had tremendous success explaining human behavior.
EPICARDIAL BRIDGING DURING LEFT ATRIAL MACROREENTRANT FLUTTER: ANATOMIC INSIGHTS FROM ULTRA-HIGH DENSITY MAPPING
Authors: Hemal M. Nayak, Raj Patel, Elliot Lee, Agatha Kwasnik, Dalise Shatz, Andrew D. Beaser, Zaid Aziz, Gaurav A. Upadhyay, Michael Broman, Cevher Ozcan, Andrew Chen, Zenith Jameria, Arun Kannan, Roderick Tung
Journal: Journal of the American College of Cardiology (2020)
Record-3: Phase II randomized trial comparing sequential first-line everolimus (EVE) and second-line sunitinib (SUN) versus first-line SUN and second-line EVE in patients with metastatic renal cell carcinoma (mRCC).
Authors: Robert John Motzer, Carlos H. Barrios, Tae Min Kim, Silvia Falcon, Thomas Cosgriff, W. Graydon Harker, Kenneth B. Pittman, Roberto Sabbatini, Sun Young Rha, Thomas W. Flaig, Ray D. Page, Sevil E. Bavbek, J. Thaddeus Beck, Poulam M Patel, Edward Schiff, Alexandra Vaury, Julie Niolat, Sven Gogov, Ozlem Anak, Jennifer Knox
Journal: Journal of Clinical Oncology (2013)

4504 Background: Sequential SUN (tyrosine kinase inhibitor, TKI) until progression of disease (PD) followed by EVE (mTOR inhibitor) is standard therapy for patients with mRCC. This open-label, multicenter, phase II trial compared 1st-line EVE to 1st-line SUN (NCT00903175). Sequential EVE→SUN was also compared with standard SUN→EVE. Methods: Patients with mRCC (clear or non-clear cell) naive to prior systemic therapy were randomized 1:1 to either 1st-line EVE 10 mg/day or SUN 50 mg/day (4 weeks on, 2 weeks off) until PD. Patients then crossed over and continued on the alternate drug until PD. Primary objective was to assess PFS noninferiority of 1st-line EVE to 1st-line SUN; defined as an observed hazard ratio (HR) 1st EVE/SUN ≤1.1. Overall survival (OS), combined 1st-line and 2nd-line PFS, and safety were secondary end points. Results: From10/09 to 6/11, 471 patients enrolled (EVE→SUN, n = 238; SUN→EVE, n = 233). Median age was 62 years, 85.4% had clear-cell RCC, and MSKCC favorable/intermediate/poor risk was 30/56/14%. Median follow-up was 22.7 months. A total of 53.7% of patients who discontinued 1st-line EVE entered into 2nd-line SUN and 51.6% of patients who discontinued 1st-line SUN entered into 2nd-line EVE. Median PFS (95% CI) was 7.9 (5.6-8.2) months for 1st-line EVE and 10.7 (8.2-11.5) months for 1st-line SUN. HR 1st EVE/1st SUN (95% CI) was 1.43 (1.15-1.77). Median OS (95% CI) was 22.4 (19.7-NA) months for EVE→SUN and 32.0 (20.5-NA) months for SUN→EVE; HR EVE-SUN/SUN-EVE (95% CI) was 1.24 (0.94-1.64). A trend in favor of SUN→EVE for OS was observed, but will need to be confirmed with final OS analysis. Additional efficacy results for secondary end points are forthcoming. Common treatment-emergent adverse events for 1st-line EVE vs SUN, respectively, were stomatitis (53% vs 57%), fatigue (45% vs 51%), and diarrhea (38% vs 57%). Conclusions: Noninferiority of PFS for 1st-line EVE compared with SUN was not achieved in this randomized phase II trial of mRCC patients. The treatment paradigm remains SUN→EVE since the sequence achieved optimal clinical benefit. Clinical trial information: NCT00903175.
CHARACTERIZING REASONS FOR READMISSION EARLY, LATE, AND VERY LATE AFTER ACUTE MYOCARDIAL INFARCTION
Authors: Raunak M. Nair, Chetan Huded, Mouin S. Abdallah, Michael Joseph Johnson, Kathleen Kravitz, Jeevanantham Rajeswaran, Moses Anabila, Eugene Blackstone, A. Lincoff, Samir Kapadia, Venu Menon, Umesh Khot
Journal: Journal of the American College of Cardiology (2020)
PREOPERATIVE PULMONARY HYPERTENSION IS ASSOCIATED WITH RISK OF LONG-TERM MAJOR ADVERSE CARDIOVASCULAR EVENTS IN PATIENTS UNDERGOING LIVER TRANSPLANTATION
Authors: Anoop Ninan Koshy, Mark Horrigan, Paul J. Gow, Anees Enayati, Benjamin Cailes, Jefferson Ko, Matthew Peverelle, Laurence Weinberg, Hui-Chen Han, Andrew W. Teh, Omar Farouque
Journal: Journal of the American College of Cardiology (2020)
Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism
Authors: Gurpreet S. Baht, Akshay Bareja, David E. Lee, Rajesh R. Rao, Rong Huang, Janet L. Huebner, David B. Bartlett, Corey R. Hart, Jason R. Gibson, Ian R. Lanza, Virginia B. Kraus, Simon G. Gregory, Bruce M. Spiegelman, James P. White
Journal: Nature Metabolism (2020)
TRADITIONAL INFUSION CATHETER VERSUS ULTRASOUND ASSISTED CATHETER DIRECTED THROMBOLYSIS FOR THE TREATMENT OF SUBMASSIVE PULMONARY EMBOLISM
Authors: Ryan Orgel, Fawzi Ameer, Eric Pauley, Hubert Haywood, Apoorva Gupta, Xuming Dai, Joseph Rossi
Journal: Journal of the American College of Cardiology (2020)
The study of in vivo acute effect of two different delivery modalities of iron oxide core with titanium dioxide shell nanoparticles in rabbits liver tumor.
Authors: Tamer Refaat, Derek West, Samar Elachy, Vamsi Parimi, Jasmine May, Kathleen R. Harris, Andrew C. Larson, Reed A. Omary, Tatjana Paunesku, Gayle Woloschak
Journal: Journal of Clinical Oncology (2013)

e22204 Background: To compare intravenous (IV) versus fluoroscopy-guided transarterial intra-catheter (IC) delivery of iron oxide core with titanium dioxide shell nanoparticles (NPs) in vivo in VX2 model of liver cancer in rabbits and detect the NPs distribution and effect of NPs presence on the target tumor and other rabbit’s organs. Methods: After obtaining the IACUC approval, liver tumors were obtained by implantation of tumor tissue obtained from a hind limb VX2 tumor of donor rabbits. NPs were delivered either IV or IC. After rabbit termination, 2 hours post NPs injection, tumor, liver, kidney, lung and spleen were harvested, split in half and a part of it was frozen while the remainder was formalin fixed and paraffin embedded. To assess the NPs distribution in 2D we stained 5um thick paraffin tissue sections using Dopamine-Biotin-DHS histochemical (HC) staining followed by Nanozoomer microscopy analysis. H and E staining, TUNEL assay and Ki67 immunohistochemistry were also done. X-ray Fluorescence Microscopy (XFM) was used to quantify the NPs. Frozen tissue was used for bulk NPs concentration analysis using Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Results: This study included ten rabbits; 3 rabbits had IV NPs injections, 3 had IC NPs injection, 2 control and 2 donors. ICP-MS analysis showed statistically significant higher NPs concentration in tumors of IC arm vs. IV arm (p= 0.0356), while there was higher concentration of NPs in liver (p=0.00077) and spleen (p = 0.01356) of IV vs. IC arms but no difference in kidneys or lungs. These findings were consistent with results from HC and XFM analyses. HC 2D analysis of NPs distribution showed that the RES have taken up the NPs non-specifically. There were no statistically significant differences between the treatment groups regarding the Ki67 proliferation or the TUNEL apoptosis indices or when control rabbits were compared to NPs treated rabbits. Conclusions: Both IV and IC NPs injection are feasible modalities for delivering NPs to tumors with acceptable acute systemic effects and comparable tumor effect. IV delivery increased sequestration of the NPs by RES and their accumulation in spleen and liver.
Not All Hypertension Is a Lifelong Disease
Authors: Shumin Yang, Jinbo Hu, Qifu Li
Journal: JAMA Internal Medicine (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Contrast-Associated Acute Kidney Injury and Serious Adverse Outcomes Following Angiography
Authors: Steven D. Weisbord, Paul M. Palevsky, James S. Kaufman, Hongsheng Wu, Maria Androsenko, Ryan E. Ferguson, Chirag R. Parikh, Deepak L. Bhatt, Martin Gallagher
Journal: Journal of the American College of Cardiology (2020)
Isolated Pancreatic Metastasis From Squamous Cell Lung Cancer Mimicking Primary Pancreatic Ductal Adenocarcinoma on FDG PET/CT
Authors: Wei Zhou, Hui Dong, Aisheng Dong
Journal: Clinical Nuclear Medicine (2020)

Isolated pancreatic metastasis from lung cancer is rare. We present a case of isolated pancreatic metastasis from squamous cell lung cancer. The pancreatic tumor showed hypovascularity on enhanced MRI and intense FDG uptake on FDG PET/CT mimicking primary pancreatic ductal adenocarcinoma. This case indicates pancreatic metastasis should be considered as a differential diagnosis in patients with a history of extrapancreatic cancer and hypermetabolic pancreatic lesion.