tbuckley/cabot-search huggingface dataset:
Economic burden of hematologic adverse events (AEs) associated with metastatic colorectal cancer (mCRC) treatment in the United States (US).
Authors: Dominick Latremouille-Viau, Jane Chang, Annie Guerin, Sherry Shi, Ed Wang, Justin Yu, Christopher Ngai
Journal: Journal of Clinical Oncology (2016)

e15008 Background: Hematologic (HEM) AEs are common during treatment (tx) for mCRC and have been associated with a significant economic burden. This study assessed the incremental costs of HEM AEs vs. non-HEM AEs in mCRC patients (pts). Methods: Adult mCRC pts treated with chemotherapy (chemo) or targeted therapies were identified from a US claims database (2009 - 2014). mCRC tx episodes were classified as with HEM AEs (anemia, neutropenia, thrombocytopenia) or with non-HEM AEs (common AEs listed in product labels grouped in 8 system/organ categories) based on AEs occurring during the episode. Healthcare costs (medical + pharmacy; 2014 USD) were measured during each mCRC tx episode and reported on a monthly basis. mCRC tx episodes with HEM AEs were matched by type of tx (monotherapy/combination, chemo, anti-VEGF, and anti-EGFR) and line of tx to those with non-HEM AEs. Costs of mCRC tx episodes with HEM AEs were compared to those with non-HEM AEs, using multivariate regression models. Results: 4,158 mCRC pts with ≥ 1 mCRC tx episodes were identified (mean age = 59 years; 58% male) contributing to a total of 7,534 episodes. Of these, 2,930 mCRC tx episodes with HEM AEs were matched to 2,930 episodes with non-HEM AEs; 91% of episodes with HEM AEs had ≥ 2 AE categories, 59% of episodes with non-HEM AEs had ≥ 2 AE categories (p < .01). On average, monthly costs of mCRC tx episodes with HEM AEs were higher than those with non-HEM AEs ($19,115 vs. $17,209). After adjustment, monthly incremental costs were $2,289 (95% confidence interval [CI]: 1,553 - 3,036) higher for mCRC tx episodes with HEM AEs compared to their matched counterparts (p < .01). This difference was mainly driven by inpatient (IP) costs and outpatient (OP) costs (adjusted monthly incremental costs [95% CIs]: IP = $1,529 [1,126 - 1,985]; OP = $966 [568 - 1,375]; both p < .01). Results should be interpreted as the incremental costs of having HEM AEs along with another AE category as most of mCRC tx episodes with HEM AEs had ≥ 2 AE categories. Conclusions: Pts experiencing HEM AEs during mCRC tx episodes commonly had other type of AEs. mCRC tx episodes with HEM AEs were associated with significantly higher healthcare costs compared to those with non-HEM AEs only.
Effect of endotoxin on COX-2 dependent proliferation of NSCLC cells: Role of CD14, TLRs, and EGFR signaling
Authors: U. Grandel, A. Banat, R. Savai, B. Eul, L. Fink, W. Seeger, F. Grimminger, U. Sibelius, K. Hattar
Journal: Journal of Clinical Oncology (2009)

e22190 Background: Bacterial infections are common in NSCLC and growing evidence indicates that inflammation is contributing to cancer growth. Against this background, we investigated the effect of the bacterial cell wall components LPS on the proliferation of the NSCLC cell line A549. Methods: Proliferation of A549 cells was quantified by MTS-assay. PGE 2 production was analyzed by ELISA and COX-2 mRNA was quantified by RT-PCR. Results: Incubation of A549 cells with LPS induced a time- and dose-dependent proliferation of A549 cells. Pro-proliferative effects of endotoxin could be inhibited by neutralizing antibodies targeting CD14 and TLR4, but not by inhibition of TLR2. Interestingly, interference with COX-2 activity by the specific inhibitor NS-398 strongly attenuated the LPS-induced tumor cell proliferation. In parallel, large amounts of COX-2 dependent PGE 2 were released by LPS-stimulated A549 cells. Moreover, enhanced transcription of COX-2 specific mRNA was detected in LPS-stimulated A549 cells. Interestingly, EGFR signaling was obviously involved in LPS-induced tumor cell proliferation and PGE 2 release, as both effects could be inhibited by the neutralizing EGFR-antibody cetuximab. Conclusions: We conclude that LPS induces COX-2 dependent proliferation of A549 cells in a CD14, TLR4, and EGFR dependant manner. These effects might contribute to pathogen induced tumor proliferation in NSCLC. No significant financial relationships to disclose.
Steroid Pretreatment of Organ Donors to Prevent Postischemic Renal Allograft Failure
Authors: Alexander Kainz, Julia Wilflingseder, Christa Mitterbauer, Maria Haller, Christopher Burghuber, Paul Perco, Robert M. Langer, Georg Heinze, Rainer Oberbauer
Journal: Annals of Internal Medicine (2010)

Acute renal failure (ARF) requiring dialysis is common among recipients of renal allografts from deceased donors. This multicenter trial randomly assigned deceased donors to intravenous infusion of...
Inhibition of Mechanosensitive MicroRNA, mir-712 Decreases Endothelial Dysfunction and Atherosclerosis
Authors: Sandeep Kumar, Dong J. Son, Wakako Takabe, Chanwoo Kim, Chih W. Ni, Noah Alberts-Grill, Sang O. Kim, Wan Kyu Kim, Jai Woong Seo, Katherine Ferrara, Hanjoong Jo
Journal: Circulation (2019)
Emotional Factors in Skin Disease
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An observational study of the lung clearance index throughout childhood in cystic fibrosis: early years matter
Authors: Gwyneth Davies, Sanja Stanojevic, Emma Raywood, Julie A. Duncan, Janet Stocks, Sooky Lum, Andrew Bush, Laura Viviani, Angie Wade, Alistair Calder, Catherine M. Owens, Christophe Goubau, Siobhán B. Carr, Cara J. Bossley, Caroline Pao, Paul Aurora
Journal: European Respiratory Journal (2020)

<b>Lung clearance index (LCI) in the early years was associated with LCI during adolescence in children with cystic fibrosis. Pre-school LCI may help to identify children in whom treatment could be intensified.</b>https://bit.ly/2yKyMbM
18F-FDG PET/CT Imaging of Vasculitis Complicated With Relapsing Polychondritis
Authors: Hiroki Kamada, Kentaro Takanami, Yoshitaka Toyama, Mioko Saito, Kei Takase
Journal: Clinical Nuclear Medicine (2020)

We present a case of a 38-year-old woman who complained with cough, fever, and back pain with a weight loss. F-FDG PET/CT to search fever origin revealed uptake in the tracheobronchial and the left auricular cartilage and wall of the thoracic aorta. She underwent biopsy of the left auricle and was diagnosed with relapsing polychondritis (RP) complicating vasculitis. After steroid therapy, FDG PET/CT demonstrated regression of inflammation, showing decreases in the uptakes. Vasculitis should be considered in case of RP with systemic manifestations. Our case demonstrated the utility of FDG PET/CT in evaluation of RP lesions including aortitis.
Clinical and pathological associations with allelic loss in colorectal carcinoma [corrected]
Authors: S E Kern, E R Fearon, K W Tersmette, J P Enterline, M Leppert, Y Nakamura, R White, B Vogelstein, S R Hamilton
Journal: JAMA (1989)

Clinical and pathological associations with molecular genetic alterations were studied in colorectal carcinomas from 83 patients. Fractional allelic loss, a measure of allelic deletions throughout the genome, and allelic deletions of specific chromosomal arms (the short arm of 17 and long arm of 18) each provided independent prognostic information by multivariate analysis when considered individually with Dukes' classification. Distant metastasis was significantly associated with high fractional allelic loss and with deletions of 17p and 18q. Mutations of ras proto-oncogenes and deletions of 5q had no prognostic importance. Statistically significant associations were also found between allelic losses and a family history of cancer, left-sided tumor location, and absence of extracellular tumor mucin. Allelic deletion analysis thus identified subsets of colorectal carcinoma with increased predilection for distant metastasis and cancer-related death. Further studies may define a subset of genetic alterations that can be used clinically to help assess prognosis.
Faster, sharper, more precise: Automated Cluster-FLIM in preclinical testing directly identifies the intracellular fate of theranostics in live cells and tissue
Authors: Robert Brodwolf, Pierre Volz-Rakebrand, Johannes Stellmacher, Christopher Wolff, Michael Unbehauen, Rainer Haag, Monika Schäfer-Korting, Christian Zoschke, Ulrike Alexiev
Journal: Theranostics (2020)

Fluorescence microscopy is widely used for high content screening in 2D cell cultures and 3D models.In particular, 3D tissue models are gaining major relevance in modern drug development.Enabling direct multiparametric evaluation of complex samples, fluorescence lifetime imaging (FLIM) adds a further level to intensity imaging by the sensitivity of the fluorescence lifetime to the microenvironment.However, the use of FLIM is limited amongst others by the acquisition of sufficient photon numbers without phototoxic effects in live cells.Herein, we developed a new cluster-based analysis method to enhance insight, and significantly speed up analysis and measurement time for the accurate translation of fluorescence lifetime information into pharmacological pathways.Methods: We applied a fluorescently-labeled dendritic core-multishell nanocarrier and its cargo Bodipy as molecules of interest (MOI) to human cells and reconstructed human tissue.Following the sensitivity and specificity assessment of the fitting-free Cluster-FLIM analysis of data in silico and in vitro, we evaluated the dynamics of cellular molecule uptake and intracellular interactions.For 3D live tissue investigations, we applied multiphoton (mp) FLIM.Owing to Cluster-FLIM's statistics-based fitting-free analysis, we utilized this approach for automatization.Results: To discriminate the fluorescence lifetime signatures of 5 different fluorescence species in a single color channel, the Cluster-FLIM method requires only 170, respectively, 90 counts per pixel to obtain 95% sensitivity (hit rate) and 95% specificity (correct rejection rate).Cluster-FLIM revealed cellular interactions of MOIs, representing their spatiotemporal intracellular fate.In a setting of an automated workflow, the assessment of lysosomal trapping of the MOI revealed relevant differences between normal and tumor cells, as well as between 2D and 3D models. Conclusion:The automated Cluster-FLIM tool is fitting-free, providing images with enhanced information, contrast, and spatial resolution at short exposure times and low fluorophore concentrations.Thereby, Cluster-FLIM increases the applicability of FLIM in high content analysis of target molecules in drug development and beyond.
Pannexin 1 channels in renin-expressing cells influence renin secretion and blood pressure homeostasis
Authors: Leon J. DeLalio, Ester Masati, Suresh Mendu, Claire A. Ruddiman, Yang Yang, Scott R. Johnstone, Jenna A. Milstein, T.C. Stevenson Keller, Rachel B. Weaver, Nick A. Guagliardo, Angela K. Best, Kodi S. Ravichandran, Douglas A. Bayliss, Maria Luisa S. Sequeira-Lopez, Swapnil N. Sonkusare, Xiaohong H. Shu, Bimal Desai, Paula Q. Barrett, Thu H. Le, R. Ariel Gomez, Brant E. Isakson
Journal: Kidney International (2020)
Multilevel genome typing: genomics-guided scalable resolution typing of microbial pathogens
Authors: Michael Payne, Sandeep Kaur, Qinning Wang, Daneeta Hennessy, Lijuan Luo, Sophie Octavia, Mark M. Tanaka, Vitali Sintchenko, Ruiting Lan
Journal: Eurosurveillance (2020)

Background Both long- and short-term epidemiology are fundamental to disease control and require accurate bacterial typing. Genomic data resulting from implementation of whole genome sequencing in many public health laboratories can potentially provide highly sensitive and accurate descriptions of strain relatedness. Previous typing efforts using these data have mainly focussed on outbreak detection. Aim We aimed to develop multilevel genome typing (MGT), using consecutive multilocus sequence typing (MLST) schemes of increasing sizes, stepping up from seven-gene MLST to core genome MLST, to allow examination of genetic relatedness at multiple resolution levels. Methods The system was applied to Salmonella enterica serovar Typhimurium. The MLST scheme used at each step (MGT level), defined a given MGT-level specific sequence type (ST). The list of STs generated from all of these increasing MGT levels, was named a genome type (GT). Using MGT, we typed 9,096 previously characterised isolates with publicly available data. Results Our approach could identify previously described S. Typhimurium populations, such as the DT104 multidrug resistance lineage (GT 19-2-11) and two invasive lineages of African isolates (GT 313-2-3 and 313-2-752). Further, we showed that MGT-derived clusters can accurately distinguish five outbreaks from each other and five background isolates. Conclusion MGT provides a universal and stable nomenclature at multiple resolutions for S . Typhimurium strains and could be implemented as an internationally standardised strain identification system. While established so far only for S. Typhimurium, the results here suggest that MGT could form the basis for typing systems in other similar microorganisms.
Lingual Thyroid
Authors: STEVEN M. SNYDER
Journal: Annals of Internal Medicine (1974)

Comments1 May 1974Lingual ThyroidSTEVEN M. SNYDER, M.D.STEVEN M. SNYDER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-5-675_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: After reading the August 1973 paper (Ann Intern Med 29:205-210) by Neinas and colleagues on the lingual thyroid, I wish to report other unusual findings in a patient with a lingual thyroid.The patient, a 67-year-old white man, has a large area of calcification in his lingual thyroid (Figure 1), and, in addition, a surgically-proved and treated Zenker's diverticulum. He has had an idiopathic enlargement of the sella turcica for at least 7 years. Two pneumoencephalograms have failed to show air in the sella, and a past craniotomy at another hospital did not show suspected suprasellar extension... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Endocrinology and Nuclear Medicine Veterans Administration Hospital San Francisco, California 94121 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1974Volume 80, Issue 5Page: 675-675KeywordsThyroid ePublished: 1 December 2008 Issue Published: 1 May 1974 PDF downloadLoading ...
Capecitabine (X) plus gemcitabine (G) as first-line treatment in patients (pts) with locally advanced/metastatic pancreatic cancer: preliminary results from an open-label, multicenter phase II study
Authors: Hong Suk Song, Young Rok Do, Heung Moon Chang, Min Hee Ryu, Kyung Hee Lee, Yeul Hong Kim, Dae Sik Hong, Jae Yong Cho, Kyoung Eun Lee, Si Young Kim
Journal: Annals of Oncology (2018)
Peroral endoscopic myotomy with simultaneous submucosal and muscle dissection in spastic esophageal disorder
Authors: Mann Yie Thian, Shinwa Tanaka, Hirofumi Abe, Hiroya Sakaguchi, Nobuaki Ikezawa, Takashi Toyonaga, Yuzo Kodoma
Journal: Endoscopy (2020)

Peroral endoscopy myotomy (POEM) is widely known as a treatment modality for achalasia and its use has been expanding to other spastic esophageal motility disorders [1] [2]. POEM with simultaneous submucosal and muscle dissection (POEM-SSMD) has been described for achalasia with severe adhesions in the submucosa of the cardia [3]. We present a challenging case, in which tunneling within the submucosa alone before the myotomy was not possible owing to spastic contractions in the mid-esophagus.
The emerging roles of vacuolar-type ATPase-dependent Lysosomal acidification in neurodegenerative diseases
Authors: Qiaoyun Song, Bo Meng, Haidong Xu, Zixu Mao
Journal: Translational Neurodegeneration (2020)

Abstract Background Lysosomes digest extracellular material from the endocytic pathway and intracellular material from the autophagic pathway. This process is performed by the resident hydrolytic enzymes activated by the highly acidic pH within the lysosomal lumen. Lysosome pH gradients are mainly maintained by the vacuolar (H + ) ATPase (or V-ATPase), which pumps protons into lysosomal lumen by consuming ATP. Dysfunction of V-ATPase affects lysosomal acidification, which disrupts the clearance of substrates and leads to many disorders, including neurodegenerative diseases. Main body As a large multi-subunit complex, the V-ATPase is composed of an integral membrane V0 domain involved in proton translocation and a peripheral V1 domain catalyzing ATP hydrolysis. The canonical functions of V-ATPase rely on its H + -pumping ability in multiple vesicle organelles to regulate endocytic traffic, protein processing and degradation, synaptic vesicle loading, and coupled transport. The other non-canonical effects of the V-ATPase that are not readily attributable to its proton-pumping activity include membrane fusion, pH sensing, amino-acid-induced activation of mTORC1, and scaffolding for protein-protein interaction. In response to various stimuli, V-ATPase complex can reversibly dissociate into V1 and V0 domains and thus close ATP-dependent proton transport. Dysregulation of pH and lysosomal dysfunction have been linked to many human diseases, including neurodegenerative disorders such as Alzheimer disease, Parkinson’s disease, amyotrophic lateral sclerosis as well as neurodegenerative lysosomal storage disorders. Conclusion V-ATPase complex is a universal proton pump and plays an important role in lysosome acidification in all types of cells. Since V-ATPase dysfunction contributes to the pathogenesis of multiple neurodegenerative diseases, further understanding the mechanisms that regulate the canonical and non-canonical functions of V-ATPase will reveal molecular details of disease process and help assess V-ATPase or molecules related to its regulation as therapeutic targets.
Reflux symptoms and oesophageal acidification in treated achalasia patients are often not reflux related
Authors: Fraukje A Ponds, Jacobus M Oors, André J P M Smout, Albert J Bredenoord
Journal: Gut (2020)

After treatment, achalasia patients often develop reflux symptoms. Aim of this case-control study was to investigate mechanisms underlying reflux symptoms in treated achalasia patients by analysing oesophageal function, acidification patterns and symptom perception.Forty treated achalasia patients (mean age 52.9 years; 27 (68%) men) were included, 20 patients with reflux symptoms (RS+; Gastro-Oesophageal Reflux Disease Questionnaire (GORDQ) ≥8) and 20 without reflux symptoms (RS-: GORDQ <8). Patients underwent measurements of oesophagogastric junction distensibility, high-resolution manometry, timed barium oesophagogram, 24 hours pH-impedance monitoring off acid-suppression and oesophageal perception for acid perfusion and distension. Presence of oesophagitis was assessed endoscopically.Total acid exposure time during 24 hours pH-impedance was not significantly different between patients with (RS+) and without (RS-) reflux symptoms. In RS+ patients, acid fermentation was higher than in RS- patients (RS+: mean 6.6% (95% CI 2.96% to 10.2%) vs RS-: 1.8% (95% CI -0.45% to 4.1%, p=0.03) as well as acid reflux with delayed clearance (RS+: 6% (95% CI 0.94% to 11%) vs RS-: 3.4% (95% CI -0.34% to 7.18%), p=0.051). Reflux symptoms were not related to acid in both groups, reflected by a low Symptom Index. RS+ patients were highly hypersensitive to acid, with a much shorter time to heartburn perception (RS+: 4 (2-6) vs RS-:30 (14-30) min, p<0.001) and a much higher symptom intensity (RS+: 7 (4.8-9) vs RS-: 0.5 (0-4.5) Visual Analogue Scale, p<0.001) during acid perfusion. They also had a lower threshold for mechanical stimulation.Reflux symptoms in treated achalasia are rarely caused by gastro-oesophageal reflux and most instances of oesophageal acidification are not reflux related. Instead, achalasia patients with post-treatment reflux symptoms demonstrate oesophageal hypersensitivity to chemical and mechanical stimuli, which may determine symptom generation.
LBA1 Interim results of a phase I/Ib study of LSZ102, an oral selective estrogen receptor degrader (SERD), in combination with ribociclib (RIB) or alpelisib (ALP) in patients with ER+ breast cancer (BC) who had progressed after endocrine therapy (ET)
Authors: K. Jhaveri, D. Juric, Y-S. Yap, S. Cresta, R. Layman, F. Duhoux, C. Terret, S. De Vita, N. Kundamal, W. He, A. Balbin, Q. Sheng, A. Crystal, G. Curigliano
Journal: Annals of Oncology (2020)
Abstract 12696: Safety and Clinical Effectiveness of Left Atrial Appendage Occlusion in Patients With Chronic Kidney Disease
Authors: Domenico G Della Rocca, Alessio Gasperetti, Gaetano Fassini, Sanghamitra Mohanty, Chintan Trivedi, Veronica N Natale, Rodney Horton, Carola Gianni, Amin Al-Ahmad, John D Burkhardt, Fahim A Choudhury, Mustafa A Moheeth, G. Joseph Gallinghouse, Patrick Hranitzky, Javier E Sanchez, Prasant Mohanty, Luigi Di Biase, Claudio Tondo, Andrea Natale
Journal: Circulation (2018)

Introduction: Left atrial appendage occlusion (LAAO) might be particularly attractive in CKD patients, owing to a high risk of thromboembolic (TE) events and an even higher risk of bleeding. Hypoth...
Covid-19 care before, during, and beyond the hospital
Authors: Alicia L Rauh, Jeffrey A Linder
Journal: BMJ (2020)

The extraction procedure and the effects of sodium hydroxide concentration, time, and temperature of extraction on protein extractability from wine lees were evaluated. An optimum was found for disintegrated wine lees after extraction for 30 minutes at 50°C with 0.8% sodium hydroxide at pH 12.5. The Kjeldahl protein obtained by acid precipitation (pH 3.5) of the alkaline extract represented 45% of total wine-lees protein.
Abstract 12332: Diagnostic Accuracy of a Novel Stress Echocardiography Pattern for Myocardial Bridge in Patients With Angina and No Obstructive Coronary Artery Disease - a Retrospective and Prospective Validation Cohort Study
Authors: Vedant S Pargaonkar, Ian S Rogers, Jessica Su, Signe Helene Forsdahl, Donald Schreiber, Frandics P Chan, Hans-Christoph Becker, Dominik Fleischmann, Jennifer A Tremmel, Ingela Schnittger
Journal: Circulation (2018)

Background: A subset of patients with angina in the absence of obstructive coronary artery disease (CAD) may have a myocardial bridge (MB) as a cause of their symptoms. We previously reported a nov...