tbuckley/cabot-search huggingface dataset:
Upregulation of PD-L1 on Myeloma Cells By Immunomodulatory Agents Potentiates the Effect of Durvalumab
Authors: Mariko Ishibashi, Junichi Yamamoto, Takumi Ito, Hiroshi Handa, Koiti Inokuchi, Hidemi Takahashi, Hideto Tamura
Journal: Blood (2018)
AB1057 Brucellar spondylodiscitis: the imaging findings
Authors: O. Saidane, I. Oueslati, R. Tekaya, A. Ben Tekaya, I. Mahmoud, L. Abdelmoula
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Brucellar spondylodiscitis is an important complication of brucellosis that can cause neurologic involvement and spinal deformities if not appropriately treated. Imaging examination is a major key in diagnosis <h3>Objectives</h3> The aim of this study was to report the imaging findings in brucellar spondylodiscitis <h3>Methods</h3> We performed a retrospective study including 27 patients with Brucellar spondylodiscitis over a period of 17 years from 2000 to 2016. Diagnosis was made on clinical presentation, laboratory findings, radiographic evidence and Brucellar seroagglutination tests. All patients underwent X-rays of the involved spine levels. Spinal computed tomography (CT)was carried out in 13 cases and spinal MRI in 24 cases <h3>Results</h3> seventeen men and 10 women aged from 33 to 75 years were included. Plain radiographs showed a disc space narrowing for 26 patients (96,3%) and an irregularity of the vertebral end plate in 16 cases (59,3%). A paravertebral abscess formation was detected for 3 patients. No obvious abnormalities were found in one case. CT scans of most patients revealed signs of spondylodiscitis (92,3%). This examination showed an erosion of the vertebral end plates (69.2%), intervetebral disc space narrowing (61,5%)and bone destruction (38.5%). The severity signs detected on the CTs were the soft tissu thickening (46.2%), abscesses formations (7.4%), epiduritis (30.8%) and one patient had a spinal cord compression. The 24 MRIs realised exhibited a signal abnormality of the vertebral body (95.7%) and the intervertebral disc (47.8%) in addition to disc space narrowing (73.9%) with erosions of the vertebral end plates (56.0%). The contrast enhanced T1-weighted images showed marked enhancement of affected vertebrae and disc (78.3%). Thirteen patients had abscesses formations (56,5%), 17 had epiduritis (73,9%) and 9 patients (31,9%) presented a spinal cord compression on MRI. Brucellar spondylodiscitis involved one spinal level in 23 cases whereas multilevel involvement was found in the 4 others <h3>Conclusions</h3> plain radiographs and spinal CT scans luck sensitivity in diagnosing brucellar spondylodiscitis and spinal MRI remains the referential imaging modality to recognise early bone infection, allowing complete lesion topography and identifying the complications. <h3>Disclosure of Interest</h3> None declared
THU0610 Serum calprotectin levels in behÇet’s disease: relationships between disease activity and clinical parameters
Authors: M. Torgutalp, A.B. Kelesoglu Dincer, E.M. Yayla, E. Uslu Yurteri, E.I. Okatan, G.E. Aydemir Guloksuz, S. Sezer, E. Us, G. Kinikli, M.T. Turgay, A. Ates
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Behçet's disease (BD) is an inflammatory disease with chronic systemicvasculitis. The disease is characterised by attacks of oral and genital ulcers, skin lesions, arthritis, uveitis and deep vein thrombosis. The main histopathologic feature is known to be vascular inflammatory changes. Calprotectin is expressed by granulocytes, monocytes and endothelial cells, and produce an inflammatory response in human microvascular endothelial cells. <h3>Objectives</h3> The aim of this study was to evaluate serum calprotectin levels and their relationships with disease-related variables in patients with BD. <h3>Methods</h3> Forty-eight patients diagnosed with BD according to International Study Group of BD classification criteria and 22 demographically matched healthy control subjects participated in this study. Calprotectin levels were measured in blood samples from patients and controls. The disease durations of the patients were between 1 and 28 years. The Behçet's Disease Current Activity Form (BDCAF), that scores the history of clinical features presenting during four weeks prior to the day of assessment, and <i>Behçet's Syndrome</i> Activity Scale (<i>BSAS)</i> were used for the evaluation of disease activity. <h3>Results</h3> Mean serum calprotectin levels were significantly higher in patients withBD compared to the control group (60.6±43.8, 37.6±37.5, respectively; p=0.037) (Figüre 1). Distribution of age (years; 40.6±12.9, 46.6±11.4, respectively; p=0.075) and sex (male; 62.5%, 45.5%, respectively, p=0.191) between these groups were similar. In the comparison of the calprotectin levels of the patients with or without the components of BD, we found significantly higher levels of calprotectin in patients with oral and genital ulceration versus without these involvements (table 1). Since there were only 2 uveitis patients in this patient group, no calculations were made on uveitis. Serum calprotectin was significantly associated with BDCAF, BSAS, patient's impression of disease activity, clinician's impression of disease activity, ESR (Erythrocyte sedimentation rate) and CRP (C-reactive protein) (table 2). <h3>Conclusions</h3> Our study demonstrated that serum calprotectin levels were significantly higher in patients with BD relative to the control group, and were significantly correlated with disease activity scores. The presence of a newly-developed genital and oral ulceration may be associated with higher levels of calprotectin. It can be concluded that serum calprotectin level seems to be useful marker to monitor disease activity in BD. <h3>Disclosure of Interest</h3> None declared
Eltrombopag for the Treatment of Aplastic Anemia in Europe
Authors: Beatrice Drexler, Matyas Ecsedi, Etienne Lengline, Cora Knol, Paul Bosman, Boris Afanasiev, Alexey A. Maschan, Peter Dreger, Constantijn J.M. Halkes, Agostino Cortelezzi, Bernard Drenou, Gianluca Gaidano, Benedetto Bruno, Daniela Onofrillo, Edoardo Lanino, Drazen Pulanic, Ranka Serventi-Seiwerth, Alice Garnier, Per Ljungman, Francesca Bonifazi, Sabrina Giammarco, Olivier Tournilhac, Pietro Pioltelli, Alicia Rovo, Regis Peffault De Latour, Carlo Dufour, Jakob R. Passweg, for the EBMT SAA Working Party
Journal: Blood (2018)
Diverse roles in UK primary care affect use of tests
Authors: Linus U Onah
Journal: BMJ (2019)

O’Sullivan and colleagues report on the temporal trends of test use in UK primary care,1 but they focus almost exclusively on general practitioners as if they are synonymous with primary care. This is a common mistake, brought into sharper focus by the rapidly changing composition of the general practice workforce.

As at June 2018, there were 27 396 full time equivalent …
When Is Death in a Child’s Best Interest?
Authors: Melissa D. McCradden, James A. Anderson, Michael D. Cusimano
Journal: JAMA Pediatrics (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
ASXL1 alteration cooperates with JAK2V617F to accelerate myelofibrosis
Authors: Ying Guo, Yuan Zhou, Shohei Yamatomo, Hui Yang, Peng Zhang, Shi Chen, Stephen D. Nimer, Zhizhuang Joe Zhao, Mingjiang Xu, Jie Bai, Feng-Chun Yang
Journal: Leukemia (2019)
Myofibroblasts acquire retinoic acid–producing ability during fibroblast-to-myofibroblast transition following kidney injury
Authors: Jin Nakamura, Yuki Sato, Yuichiro Kitai, Shuichi Wajima, Shinya Yamamoto, Akiko Oguchi, Ryo Yamada, Keiichi Kaneko, Makiko Kondo, Eiichiro Uchino, Junichi Tsuchida, Keita Hirano, Kumar Sharma, Kenji Kohno, Motoko Yanagita
Journal: Kidney International (2019)

Tubular injury and interstitial fibrosis are the hallmarks of chronic kidney disease. While recent studies have verified that proximal tubular injury triggers interstitial fibrosis, the impact of fibrosis on tubular injury and regeneration remains poorly understood. We generated a novel mouse model expressing diphtheria toxin receptor on renal fibroblasts to allow for the selective disruption of renal fibroblast function. Administration of diphtheria toxin induced upregulation of the tubular injury marker Ngal and caused tubular proliferation in healthy kidneys, whereas administration of diphtheria toxin attenuated tubular regeneration in fibrotic kidneys. Microarray analysis revealed down-regulation of the retinol biosynthesis pathway in diphtheria toxin-treated kidneys. Healthy proximal tubules expressed retinaldehyde dehydrogenase 2 (RALDH2), a rate-limiting enzyme in retinoic acid biosynthesis. After injury, proximal tubules lost RALDH2 expression, whereas renal fibroblasts acquired strong expression of RALDH2 during the transition to myofibroblasts in several models of kidney injury. The retinoic acid receptor (RAR) RARγ was expressed in proximal tubules both with and without injury, and αB-crystallin, the product of an RAR target gene, was strongly expressed in proximal tubules after injury. Furthermore, BMS493, an inverse agonist of RARs, significantly attenuated tubular proliferation in vitro. In human biopsy tissue from patients with IgA nephropathy, detection of RALDH2 in the interstitium correlated with older age and lower kidney function. These results suggest a role of retinoic acid signaling and cross-talk between fibroblasts and tubular epithelial cells during tubular injury and regeneration, and may suggest a beneficial effect of fibrosis in the early response to injury.
Incidence of HLA Loss in a Global Multicentric Cohort of Post-Transplantation Relapses: Results from the Hlaloss Collaborative Study
Authors: Luca Vago, Cristina Toffalori, Müberra Ahci, Vinzenz Lange, Kathrin Lang, Sonia Todaro, Francesca Lorentino, Karin Stempelmann, Andreas Heinold, Friedrich Stoelzel, Miguel Waterhouse, Rainer Claus, Ketevan Gendzekhadze, Masahiro Onozawa, Raynier Devillier, Ruoping Tang, Maayan Ulman, Mi Kwon, Ivana Gojo, Loredana Ruggeri, Annalisa Imovilli, Luca Facchini, Dejan Lazarevic, Maria Teresa Lupo Stanghellini, Jacopo Peccatori, Nina Kristin Steckel, Peter A. Horn, Alessandra Picardi, Sara Manetta, Alessandro Busca, Jose Luis Pinana, Jaime Sanz, Carolina Martínez-Laperche, Stefan O. Ciurea, Leo Luznik, Andrea Velardi, William Arcese, Guillermo Sanz, Massimo Pini, Benedetto Bruno, Guido Kobbe, Monzr Al Malki, Takanori Teshima, Nicolaus Kroeger, Jürgen Finke, Arnon Nagler, Didier Blaise, Mohamad Mohty, Martin Bornhäuser, Dietrich W. Beelen, Alexander H. Schmidt, Fabio Ciceri, Katharina Fleischhauer
Journal: Blood (2018)
SAT0709 Subclinical hepatitis c virus infection in egyptian patients with rheumatologic diseases: a multi-centre study
Authors: S. Mahran, M. Hassanien, D.A. Nigm, A. Moshrif, M. Hasanein, M.Z.A. Abu Rahma, M.I. Risha, M.A. Hanafy, A.H. Shalaby, M. Abdelkareem, H. Hamoud, S. Ghanem, S. Abd-Elsalam, F. El-Nouby, A. fehr, E.F. Kholef, A. O. B.S. Osman, D.G. Mahran
Journal: Annals of the Rheumatic Diseases (2018)

Background  Egypt has the highest prevalence of hepatitis C virus (HCV) in the world. In 2015, the prevalence of HCV RNA was found to be 7.0%.(1 The prevalence of HCV was studied in Rheumatoid arthritis in few studies(,2,3 but to our knowledge, no previous work studied it in other rheumatologic patients.  Objectives  This study aims at detecting the prevalence of subclinical HCV infection in different rheumatologic disease groups in Egypt.  Methods  Consecutive patients with different rheumatologic diseases from seven- geographically different- rheumatology departments were prospectively studied. None of the patients was known to have previous HCV infection. Patients’ serum samples were screened for the presence of anti-HCV antibodies. Patients with positive serology were further evaluated for the presence of HCV ribonucleic acid by reverse transcriptase polymerase chain reaction (RT-PCR).  Results  1454 rheumatic patients (1242 (85.4%) women, 212 (14.5%) men) with mean age[SD] of 43.7 [12.7] years were included in this study. Both anti-HCV serology and HCV RNA were positive in 124 patients (8.5%). Positive PCR for HCV was significantly higher in the age group of 40 to   Conclusions  The detection of subclinical HCV infection in 8.5% of rheumatologic patients in Egypt with significant higher level in the middle age group, draws attention to the importance of screening for HCV in such population for early detection and intervention.  Disclosure of Interest  None declared
Abstract 555: The Universal Clinical Classification of Acute Myocardial Infarction is a Better Predictor of Long Term Outcomes than ST Segment Classification
Authors: Manuel A Gonzalez, Dana Eilen, Rana A Marzouq, Saed Awadallah, Hiren R Patel, Ricky Bloomfield, Justin M Bennett, Heang M Lim, Christopher Porterfield, Amit A Patel, Laura C Gilmore, Summiyah Nasir, Joseph D Babb, John D Rose, Wayne E Cascio
Journal: Circulation (2008)

Introduction: The universal classification (UC) of AMI aims to facilitate cross-study analysis, yet the long-term outcomes using UC are largely unknown. Hypothesis: We tested the hypothesis that the long-term outcome of patients with AMI is better predicted by UC than ST segment classification. Methods: We conducted a prospective study of 348 consecutive patients with AMI with mean follow-up of 30.6 months. The primary outcome was the major adverse cardiovascular events (MACE) [composite of all causes of mortality, recurrent AMI, and stroke]. Multivariate and survival analysis of MACE was performed. Results: The study population was STEMI=168, NSTEMI=180, Type 1=278, Type 2=55, Type 3=5, Type 4a=2, Type 4b=5, and Type 5=3. During follow-up 80 patients died, 31 had an AMI, and 7 had a stroke. UC correlates with the ST segment classification (p&lt;0.005). MACE free survival was different for Type 1 and Type 2 (p=0.043), but not for STEMI and NSTEMI. There was a positive association between MACE and the quartile of peak Troponin, number of cardiovascular risk factors, and number of vascular beds affected, and an inverse relationship with the utilization of discharge cardiovascular protective medications (all p≤0.01). No such inverse relationship existed for Type 2. Conclusions: UC of AMI is a better long-term predictor of MACE. The quartile of peak Troponin levels, cardiovascular risk factors, and number of vascular beds affected are independent predictors of MACE, while cardiac medications protect against MACE, except in Type 2 patients.
Secular TRends in DiabEtes in India (STRiDE–I): Change in Prevalence in 10 Years Among Urban and Rural Populations in Tamil Nadu
Authors: Arun Nanditha, Chamukuttan Snehalatha, Krishnamoorthy Satheesh, Priscilla Susairaj, Mary Simon, Lakshminarayanan Vijaya, Arun Raghavan, Ramachandran Vinitha, Ambady Ramachandran
Journal: Diabetes Care (2019)

OBJECTIVE The objective of the current study was to assess the secular trends in the prevalence of diabetes, prediabetes, and risk factors from two epidemiological surveys done 10 years apart in three adult populations of different geographic and socioeconomic backgrounds in Tamil Nadu, India. RESEARCH DESIGN AND METHODS This survey was conducted in 2016 using methodology similar to that used in 2006. Persons aged ≥20 years (n = 9,848) were screened for diabetes, prediabetes, and the risk variables. Fasting and 2-h plasma glucose, lipid profile, blood pressure, anthropometry, and socioeconomic and behavioral details were recorded. Comparative analyses of age-standardized prevalence were done. Prevalence ratios (PRs) between 2016 and 2006 of diabetes and also prediabetes were assessed using Poisson regression analyses. RESULTS Prevalence of diabetes increased from 18.6% (95% CI 16.6–20.5) to 21.9 (20.5–23.3) in the city, 16.4 (14.1–18.6) to 20.3 (18.9–21.6) in the town, and 9.2 (8.0–10.5) to 13.4 (11.9–14.8) in the periurban villages (PUVs) (P &amp;lt; 0.0001 in all). The PR showed a nonsignificant 8% rise in diabetes in the city, while significant increases had occurred in the town (39%) and PUVs (34%). Prevalence of prediabetes also increased. Age, family history of diabetes, and waist circumference were common risk determinants among the populations. Though general obesity and abdominal obesity increased, the latter was associated with the increased prevalence. CONCLUSIONS Prevalence of diabetes and prediabetes increased in all locations; the rise was significant only in the town and PUVs. Abdominal obesity is significantly associated with increased trend even among the villagers. Rural populations may be targeted for future public health measures to combat diabetes.
FRI0514 Anti-neutrophil cytoplasmic antibodies positivity in interstitial lung disease patients
Authors: S. Barsotti, L. Cavagna, F. Ferro, P. Tomietto, A. Pesci, G. Dei, S. Prieto-González, F. Hernández-González, L. Saracino, A. Manfredi, G. Emmi, M.L. Urban, M. Mosca, C. Baldini, R. Neri
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Interstitial lung disease (ILD) is a possible manifestation of several rheumatic diseases. Although lung involvement is common in Anti-neutrophil cytoplasmic antibodies (ANCA) vasculitides (AAV), the presence of ILD is relatively rare. Moreover, a very small subgroup of patients may present ILD along ANCA positivity without other systemic signs of AAV. <h3>Objectives</h3> To describe the phenotypic characteristics of ILD patients with ANCA positivity without a definite diagnosis of AAV. <h3>Methods</h3> ANCA-ILD patients from 7 tertiary care hospitals (6 from Italy, 1 from Spain – 2 rheumatology centres, 4 pneumology centres, 1 internal medicine) were included. The mean follow-up was of 62.6±49.8 months. We collected epidemiologic, demographic, clinical, serological, pulmonary function test (PFT) data and high resolution computed tomography (HRCT) pattern. <h3>Results</h3> 19 patients with ANCA-ILD (M:F=9:10, mean age at diagnosis 66.2±8 years) were enrolled. The mean latency between the first respiratory symptom onset and the diagnosis was 26.4±37.0 months. Sixteen patients (84%) had ANCA-MPO positivity while 3 ANCA-PR3. Antinuclear autoantibodies were positive in 12 patients (63%). Usual interstitial pneumonia was the main HRCT pattern (10, 52.6%), followed by non specific interstitial pneumonia (8, 42%, 1 associated with organising pneumonia), 1 combined pulmonary fibrosis and emphysema. Six patients with ILD-ANCA presented also a non-erosive oligoarticular inflammation (n=6). During the follow-up, the majority of the patients (16/19) did not require oxygen therapy at last evaluation. However, 1 patient required continuous O2, 1 intermittent O2, 1 patient underwent lung transplant due to respiratory failure. Five patients required hospitalisation due to respiratory insufficiency. Two patients died, both for respiratory insufficiency. All patients were treated with glucocorticoids as induction therapy (4 intravenous pulses), combined with an immunosuppressant in 11 cases: cyclophosphamide (3, 15%), azathioprine (6, 31%), mycophenolate (2, 10.5%), methotrexate (1, 5.5%) or rituximab (2, 10.5%). <h3>Conclusions</h3> the observation of ANCA positivity in patients with ILD may open new prospective in the assessment of interstitial lung diseases. Although most of patients had a good prognosis, up to 25% presented unfavourable respiratory outcome. Further prospective studies in larger cohorts and longer follow-up may clarify the prognosis of this particular lung disease and if ILD-ANCA should be classified as a distinct subset or an incomplete form of AAV. <h3>Disclosure of Interest</h3> None declared
IgA hypogammaglobulinemia predicts outcome in chronic lymphocytic leukemia
Authors: G. Reda, R. Cassin, M. Gentile, F. R. Mauro, D. Giannarelli, B. Fattizzo, M. Barbieri, I. Silvestris, S. Fabris, F. Morabito, A. Neri, W. Barcellini, A. Cortelezzi
Journal: Leukemia (2019)
Immune Exclusion-Wnt/CTNNB1 Class Predicts Resistance to Immunotherapies in HCC
Authors: Roser Pinyol, Daniela Sia, Josep M. Llovet
Journal: Clinical Cancer Research (2019)

Next-generation sequencing has provided information on actionable targets and biomarkers of response in oncology. In hepatocellular carcinoma (HCC), Wnt/CTNNB1 mutations characterize the immune-excluded class (cold tumors) and might represent the biomarkers predicting resistance to immune checkpoint inhibitors. Large-scale validation of these data is needed to customize immunotherapy in advanced HCC.See related article by Harding et al., p. 2116.