tbuckley/cabot-search huggingface dataset:
Activin-A Directly Inhibits Vascular Endothelial Cell Growth VIA TGF-b-Dependent Signal Pathway
Authors: H. Kaneda, T. Arao, K. Tanaka, K. Matsumoto, H. Kimura, T. Nagai, Y. Fujita, M.A. De Velasco, Y. Yamada, I. Okamoto, K. Nakagawa, K. Nishio
Journal: Annals of Oncology (2012)
Phase II Trial of Firstline Trial of CBDCA Plus S1 Plus Gefitinib for Patients with Advanced NSCLC Patients Harboring Activating Mutation of the EGFR Gene
Authors: T. Tsuji, M. Tamiya, A. Tamiya, N. Omachi, S. Minomo, K. Asami, K. Okishio, T. Kawaguchi, T. Shiroyama, N. Morishita, H. Suzuki, N. Okamoto, S. Kobayashi, T. Hirashima, S. Atagi
Journal: Annals of Oncology (2012)
Phase I Study of Anti PD-1 Antibody Ono-4538 in Japanese Patients with Advanced Solid Tumors
Authors: N. Yamamoto, H. Nokihara, Y. Yamada, H. Asahina, T. Shibata, Y. Tamura, Y. Seki, K. Honda, Y. Tanabe, H. Wakui, T. Tamura
Journal: Annals of Oncology (2012)
Smoking cessation and weight change in relation to cardiovascular disease incidence and mortality in people with type 2 diabetes: a population-based cohort study
Authors: Gang Liu, Yang Hu, Geng Zong, An Pan, JoAnn E Manson, Kathryn M Rexrode, Eric B Rimm, Frank B Hu, Qi Sun
Journal: The Lancet Diabetes & Endocrinology (2020)
Retrospective analysis of intravenous iron-sucrose therapy in patients undergoing chemotherapy at a tertiary-care center in India.
Authors: Jyoti Bajpai, Sudeep Gupta, Kajal Shah, Jaya Ghosh, Vanita Noronha, Kumar Prabhash, Arti Kanujia
Journal: Journal of Clinical Oncology (2012)

e13068 Background: Cancer patients frequently have anemia as a result of nutritional deficiencies, malignancy or its treatment. Administration of intravenous (IV)-iron is a therapeutic option in cancer patients with iron-deficiency-related-anemia. Methods: This is a single-institution retrospective-study of 399 patients who were undergoing chemotherapy for non-myeloid malignancies from January 2006 to December 2009 and had hemoglobin ≤11 gm/dl. They received two doses of iron-sucrose, 200-300 mg each as short IV- infusion, 3 weeks apart. The data was recorded at baseline and 3-6 weeks after IV-iron administration in all patients. Results: Of 399 patients, 326(81.7%) had non-hematological malignancies. Transferrin-saturation (TSA) was available in 149 patients. The mean (range) baseline hemoglobin, mean-corpuscular-volume (MCV) and TSA were 9.75(8.0-11.3) gm/dl, 82.4(52.5-100.3) fl and 18.38 (5.2-34.0)%, respectively. After 2 doses of IV-iron hemoglobin increased in 340 (85.2%), reduced in 32 (8.0%) and did not change in 27 (6.7%) patients. The mean (range) increase in hemoglobin was 0.7 (-3.2 to +3.2) g/dl in all patients and 0.95 (0.1-3.2) g/dl in 340 patients in whom it increased after IV-iron. The data were analyzed by low (≤ 83 fl) versus normal (&gt;83 fl) MCV and low (≤20%) versus normal (&gt;20%) TSA. Hemoglobin increased more than the mean increment (0.7 g/dl) in 63.8% patients with low MCV compared to 39.2% of patients with normal MCV (p=0.002). Hemoglobin increased more than the mean increment (0.7 g/dl) in 60.4% of patients with low TSA compared to 58.6% with normal TSA (p=0.479). These results suggest that IV iron was more efficacious in patients with low MCV. Two patients (0.005%) developed anaphylactic shock during or shortly after IV-iron administration and 35 (11.7%) had minor side effects. Thirty (7.5%) patients received RBC transfusions during their continued chemotherapy. Conclusions: Intravenous-iron improved hemoglobin during continued chemotherapy in the large majority of cancer patients with anemia and was safe and tolerable. Low MCV might serve as a surrogate for iron-deficiency-microcytic-anemia in developing-world.
Investigatin of a Disseminated Varicella in Lymphomapatient Treated with Rituximab Combined Chemotherapy
Authors: A. Okamoto, A. Abe, M. Okamoto, Y. Inaguma, M. Kanie, Y. Yamamoto, M. Tsuzuki, Y. Akatsuka, S. Mizuta, T. Yoshikawa, N. Emi
Journal: Annals of Oncology (2012)
Multiple BCL2 mutations cooccurring with Gly101Val emerge in chronic lymphocytic leukemia progression on venetoclax
Authors: Piers Blombery, Ella R. Thompson, Tamia Nguyen, Richard W. Birkinshaw, Jia-nan Gong, Xiangting Chen, Michelle McBean, Rachel Thijssen, Thomas Conway, Mary Ann Anderson, John F. Seymour, David A. Westerman, Peter E. Czabotar, David C. S. Huang, Andrew W. Roberts
Journal: Blood (2020)
Use of Integrative Therapies in Breast Cancer Patients. Health Service Research in a Network of Integrative Oncology
Authors: F. Schad, J. Axtner, A. Happe, A. Voigt, J. Gutsch, G. Spahn, C. Herbstreit, M. Debus, M. Kroez, H. Matthes
Journal: Annals of Oncology (2012)
Dose-Dense Weekly Paclitaxel and Carboplatin Is More Cost-Effective Than Bevacizumab Plus Triweekly Paclitaxel and Carboplatin for the Primary Treatment of Advanced Ovarian Cancer
Authors: K. Harano, T. Shiroiwa, M. Watanabe, K. Suzuki, T. Fukuda, S. Watanabe, N. Katsumata
Journal: Annals of Oncology (2012)
P3.12 Circulating Dna Analysis in The Era of Personalized Cancer Medicine: Application to Kras/Braf Point Mutations Detection in Colorectal Cancer
Authors: S. El Messaoudi, F. Mouliere, M. del Rio, A.S. Guedj, C. Gongora, F.M. Molina, P.J. Lamy, E. Lopez-Crapez, F. Rolet, M. Mathonnet, M. Ychou, D. Pezet, A.R. Thierry
Journal: Annals of Oncology (2012)
Alcohol Use Among Patients With Cancer and Survivors in the United States, 2000–2017
Authors: Nina N. Sanford, David J. Sher, Xiaohan Xu, Chul Ahn, Anthony V. D’Amico, Ayal A. Aizer, Brandon A. Mahal
Journal: Journal of the National Comprehensive Cancer Network (2020)

Background: Alcohol use is an established risk factor for several malignancies and is associated with adverse oncologic outcomes among individuals diagnosed with cancer. The prevalence and patterns of alcohol use among cancer survivors are poorly described. Methods: We used the National Health Interview Survey from 2000 to 2017 to examine alcohol drinking prevalence and patterns among adults reporting a cancer diagnosis. Multivariable logistic regression was used to define the association between demographic and socioeconomic variables and odds of self-reporting as a current drinker, exceeding moderate drinking limits, and engaging in binge drinking. The association between specific cancer type and odds of drinking were assessed. Results: Among 34,080 survey participants with a known cancer diagnosis, 56.5% self-reported as current drinkers, including 34.9% who exceeded moderate drinking limits and 21.0% who engaged in binge drinking. Younger age, smoking history, and more recent survey period were associated with higher odds of current, exceeding moderate, and binge drinking ( P &lt;.001 for all, except P =.008 for excess drinking). Similar associations persisted when the cohort was limited to 20,828 cancer survivors diagnosed ≥5 years before survey administration. Diagnoses of melanoma and cervical, head and neck, and testicular cancers were associated with higher odds of binge drinking ( P &lt;.05 for all) compared with other cancer diagnoses. Conclusions: Most cancer survivors self-report as current alcohol drinkers, including a subset who seem to engage in excessive drinking behaviors. Given that alcohol intake has implications for cancer prevention and is a potentially modifiable risk factor for cancer-specific outcomes, the high prevalence of alcohol use among cancer survivors highlights the need for public health strategies aimed at the reduction of alcohol consumption.
Phase I Safety and Tolerability of Once Daily Oral Afatinib (A) in Combination with Docetaxel (D) in Patients (PTS) with Relapsed or Refractory Advanced Solid Tumours
Authors: H. Senellart, J. Bennouna, N. Isambert, H. De Mont-Serrat, P. Squiban, I. Tschoepe, J. Delord
Journal: Annals of Oncology (2012)
Phase II Study of 1st-Line Combined Chemotherapy Bevacizumab with Modified Rpmi Regimen for Elderly or Frail Patients with Unresectable or Metastatic Colorectal Cancer (OGSG0802)
Authors: M. Yoshida, T. Kato, S. Iwamoto, Y. Miyake, M. Nakamura, T. Sato, D. Sakai, M. Matsuoka, T. Otsuji, H. Furukawa
Journal: Annals of Oncology (2012)
Small Bowel Adenocarcinoma Phenotype According to the Primary Localisation
Authors: T. Aparicio, M. Svrcek, A. Laforest, A. Zaanan, P. Afchain, E. Mitry, J. Taieb, F. Di Fiore, J. Gornet, P. Laurent-Puig
Journal: Annals of Oncology (2012)
Abstract 24: Association Between Serum Lactate During Cardiopulmonary Resuscitation and Survival in Adult Out-Of-Hospital Cardiac Arrest: A Multicenter Cohort Study (The Critical Study in Osaka, Japan)
Authors: Norihiro Nishioka, Daisuke Kobayashi, Junichi Izawa, Takeyuki Kiguchi, Tetsuhisa Kitamura, Takashi Kawamura, Taku Iwami
Journal: Circulation (2019)

Background: Serum lactate reflects hypoxic insult in many conditions, but its role as prognostic markers after cardiac arrest is still controversial. This study aimed to investigate the association between serum lactate levels during cardiopulmonary resuscitation (CPR) and survival in patients with out-of-hospital cardiac arrest (OHCA). Methods: This study analyzed the data of the Osaka Comprehensive Registry of Intensive Care for OHCA Survival, a prospective multicenter observational study of 14 participating institutions in Osaka Prefecture, Japan. We enrolled consecutive patients aged ≥18 years who were transported to the hospital with ongoing CPR from 2013 to 2016. Based on the serum lactate levels, OHCA patients were divided into 4 quartiles: Q1 (lactate ≤10.6 mEq/L), Q2 (10.6&lt; lactate ≤14.1 mEq/L), Q3 (14.1&lt; lactate ≤18.0 mEq/L) and Q4 (lactate &gt;18.0 mEq/L). The relationships between serum lactate level before return of spontaneous circulation (ROSC) and 1-month survival were assessed. Results: A total of 3,674 OHCA patients were included in the analysis. Overall 1-month survival was 2.3% (88/3,674). The Q1 group had the highest 1-month survival (4.6% [42/921]), followed by Q2 (2.7% [25/920]), Q3 (1.1% [11/966]) and Q4 (0.6% [5/867]), respectively (p for trend &lt; 0.001). In the multivariable logistic regression analysis, the proportion of 1-month survival in the Q4 group was significantly lower, compared with that in the Q1 group (adjusted odds ratio 0.23; 95% confidence interval 0.09 to 0.60). The adjusted proportion of 1-month survival decreased in a stepwise manner across increasing quartiles (p for trend &lt;0.001). In a subgroup analysis by initial rhythm, there was a significant interaction (p=0.003) between the rhythms: 1-month survival of OHCA patients presented with a non-shockable rhythm decreased when the lactate levels increased (p for trend &lt; 0.001), but in patients with a shockable rhythm the similar trend was not observed (p for trend = 0.574). Conclusions: The high serum lactate level before ROSC significantly associated with the worse 1-month survival after OHCA. Serum lactate may be one of the effective prognostic indications for OHCA during CPR, especially with non-shockable initial rhythm.
Peptide-based targeting of immunosuppressive cells in cancer
Authors: Noah T. Trac, Eun Ji Chung
Journal: Bioactive Materials (2020)

Cancer progression is marked by the infiltration of immunosuppressive cells, such as tumor-associated macrophages (TAMs), regulatory T lymphocytes (Tregs), and myeloid-derived suppressor cells (MDSCs). These cells play a key role in abrogating the cytotoxic T lymphocyte-mediated (CTL) immune response, allowing tumor growth to proceed unabated. Furthermore, targeting these immunosuppressive cells through the use of peptides and peptide-based nanomedicine has shown promising results. Here we review the origins and functions of immunosuppressive cells in cancer progression, peptide-based systems used in their targeting, and explore future avenues of research regarding cancer immunotherapy. The success of these studies demonstrates the importance of the tumor immune microenvironment in the propagation of cancer and the potential of peptide-based nanomaterials as immunomodulatory agents.
Comparative Efficacy of Sunitinib Versus Sorafenib as the First-Line Treatment for Patients with Metastatic Renal Cell Carcinoma
Authors: S.J. Park, J. Lee, I. Park, K. Park, J. Ahn, D.H. Lee, C. Song, J.H. Hong, C. Kim, H. Ahn
Journal: Annals of Oncology (2012)
Abstract 480: Feasibility of an Augmented Reality Cardiopulmonary Resuscitation Training System for Health Care Providers
Authors: Steve Balian, Shaun McGovern, Benjamin Abella, Audrey Blewer, Marion Leary
Journal: Circulation (2019)

Introduction: Augmented reality (AR) has the potential to offer a novel approach to CPR training that supplements conventional training methods with gamification and a more interactive learning experience. This is done through computer-generated imagery superimposed on users’ view of the real environment to simulate interactive training scenarios. Objective: We sought to test the feasibility of an AR CPR training system (CPReality) for health care providers (HCPs). Methods: In this feasibility trial, a CPR training manikin was integrated with a commercial AR device (Microsoft HoloLens) to provide participants with real-time audio-visual feedback via a holographic overlay of blood flow to vital organs dependent on CC quality. In this system, higher quality CC visually improved virtual blood circulation. HCPs performed a 2-minute cycle of hands-only CPR using only the AR system, and CC parameters were recorded. Descriptive data on participants’ demographics, CC quality, and satisfaction with the training environment were reported. Results: Between 10/2019-11/2019, we enrolled a convenience sample of 51 HCPs. The median age of participants was 31 years (IQR 27-41), 71% (36/51) were female, and 67% (34/51) were registered nurses. CC rates (mean 126 ± 12.9 cpm), depths (median 53 mm, IQR 46-58), and percent with complete recoil (median 80%, IQR 12-100) were consistent with guideline recommendations for good quality CPR. Participants were predominantly satisfied with the system, with 82% perceiving the experience as realistic, 98% recognizing the visualizations as helpful for training, and 94% willing to use the application in future CPR training. Conclusions: As AR is increasingly applied in the healthcare setting, integration in CPR training offers a novel and promising educational approach. In this convenience sample of trained HCPs, high quality CC delivery was feasible using the AR CPR training system which was received favorably by most participants.
Intergroup collaboration in ovarian cancer: a giant step forward
Authors: M.J. Piccart, G.C.E. Stuart, J. Cassidy, K. Bertelsen, M.K.B. Parmar, E.A. Eisenhauer, S.B. Kaye, C. Tropé, K. Swenerton, P. Harper, J.B. Vermorken
Journal: Annals of Oncology (1999)
Automatic, computer-aided determination of endoscopic and histological inflammation in patients with mild to moderate ulcerative colitis based on red density
Authors: Peter Bossuyt, Hiroshi Nakase, Séverine Vermeire, Gert de Hertogh, Tom Eelbode, Marc Ferrante, Tadashi Hasegawa, Hilde Willekens, Yousuke Ikemoto, Takao Makino, Raf Bisschops
Journal: Gut (2020)

Background The objective evaluation of endoscopic disease activity is key in ulcerative colitis (UC). A composite of endoscopic and histological factors is the goal in UC treatment. We aimed to develop an operator-independent computer-based tool to determine UC activity based on endoscopic images. Methods First, we built a computer algorithm using data from 29 consecutive patients with UC and 6 healthy controls (construction cohort). The algorithm (red density: RD) was based on the red channel of the red-green-blue pixel values and pattern recognition from endoscopic images. The algorithm was refined in sequential steps to optimise correlation with endoscopic and histological disease activity. In a second phase, the operating properties were tested in patients with UC flares requiring treatment escalation. To validate the algorithm, we tested the correlation between RD score and clinical, endoscopic and histological features in a validation cohort. Results We constructed the algorithm based on the integration of pixel colour data from the redness colour map along with vascular pattern detection. These data were linked with Robarts histological index (RHI) in a multiple regression analysis. In the construction cohort, RD correlated with RHI (r=0.74, p&lt;0.0001), Mayo endoscopic subscores (r=0.76, p&lt;0.0001) and UC Endoscopic Index of Severity scores (r=0.74, p&lt;0.0001). The RD sensitivity to change had a standardised effect size of 1.16. In the validation set, RD correlated with RHI (r=0.65, p=0.00002). Conclusions RD provides an objective computer-based score that accurately assesses disease activity in UC. In a validation study, RD correlated with endoscopic and histological disease activity.
BMX Represses Thrombin-PAR1–Mediated Endothelial Permeability and Vascular Leakage During Early Sepsis
Authors: Zhao Li, Mingzhu Yin, Haifeng Zhang, Weiming Ni, Richard W. Pierce, Huanjiao Jenny Zhou, Wang Min
Journal: Circulation Research (2020)

Rationale: BMX (bone marrow kinase on the X chromosome) is highly expressed in the arterial endothelium from the embryonic stage to the adult stage in mice. It is also expressed in microvessels and the lymphatics in response to pathological stimuli. However, its role in endothelial permeability and sepsis remains unknown. Objective: We aimed to delineate the function of BMX in thrombin-mediated endothelial permeability and the vascular leakage that occurs with sepsis in cecal ligation and puncture models. Methods and Results: The cecal ligation and puncture model was applied to WT (wild type) and BMX-KO (BMX global knockout) mice to induce sepsis. Meanwhile, the electric cell-substrate impedance sensing assay was used to detect transendothelial electrical resistance in vitro and, the modified Miles assay was used to evaluate vascular leakage in vivo. We showed that BMX loss caused lung injury and inflammation in early cecal ligation and puncture–induced sepsis. Disruption of BMX increased thrombin-mediated permeability in mice and cultured endothelial cells by 2- to 3-fold. The expression of BMX in macrophages, neutrophils, platelets, and lung epithelial cells was undetectable compared with that in endothelial cells, indicating that endothelium dysfunction, rather than leukocyte and platelet dysfunction, was involved in vascular permeability and sepsis. Mechanistically, biochemical and cellular analyses demonstrated that BMX specifically repressed thrombin-PAR1 (protease-activated receptor-1) signaling in endothelial cells by directly phosphorylating PAR1 and promoting its internalization and deactivation. Importantly, pretreatment with the selective PAR1 antagonist SCH79797 rescued BMX loss-mediated endothelial permeability and pulmonary leakage in early cecal ligation and puncture–induced sepsis. Conclusions: Acting as a negative regulator of PAR1, BMX promotes PAR1 internalization and signal inactivation through PAR1 phosphorylation. Moreover, BMX-mediated PAR1 internalization attenuates endothelial permeability to protect vascular leakage during early sepsis.
Intratumoral expression of IL-7 and IL-12 using an oncolytic virus increases systemic sensitivity to immune checkpoint blockade
Authors: Shinsuke Nakao, Yukinori Arai, Mamoru Tasaki, Midori Yamashita, Ryuji Murakami, Tatsuya Kawase, Nobuaki Amino, Motomu Nakatake, Hajime Kurosaki, Masamichi Mori, Masahiro Takeuchi, Takafumi Nakamura
Journal: Science Translational Medicine (2020)

Oncolytic vaccinia virus encoding IL-7 and IL-12 facilitates immune checkpoint blockade in treatment-resistant solid tumors.
Baseline Plasma Biomarker Signature is Associated with Improved Survival in Advanced nsclc Patients on Linifanib
Authors: E.M. Mc Keegan, P.J. Ansell, G. Davis, S. Chan, R.K. Chandran, S. Gawel, M.D. McKee, J.L. Ricker, D.M. Carlson, V. Devanarayan
Journal: Annals of Oncology (2012)
Natural History of Bone Metastasis in Gastric Cancer: Results of an Italian Multicenter Survey
Authors: N. Silvestris, S. Leo, T. Di Palma, F. De Vita, T. Gamucci, S. Barni, R. Ferrara, C. Mazzara, G. Numico, G. Colucci
Journal: Annals of Oncology (2012)
On believing that time does not flow, but thinking that it seems to
Authors: Kristie Miller, Alex O. Holcombe, Andrew J. Latham
Journal: Behavioral and Brain Sciences (2019)

Hoerl & McCormack (H&M) posit two systems - the temporal updating system and the temporal reasoning system - and suggest that they explain an inherent contradiction in people's naïve theory of time. We suggest there is no contradiction. Something does, however, require explanation: the tension between certain sophisticated beliefs about time, and certain phenomenological states or beliefs about those phenomenological states. The temporal updating mechanism posited by H&M may contribute to this tension.
Kras Status as Predictive Marker of Response and Time to Progression in EGFR Wild-Type Stage IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC) Patients Treated with Platin-Docetaxel-Bevacizumab
Authors: M. Domine, F. Rojo, Y. Izarzugaza, S. Zazo, F. Lobo, M. Fernandez Aceñero, J. Madoz, V. Casado, G. Rubio, J. Garcia-Foncillas
Journal: Annals of Oncology (2012)
The American Thoracic Society/European Respiratory Society 2019 Spirometry Statement and Occupational Spirometry Testing in the United States
Authors: Mary C. Townsend
Journal: American Journal of Respiratory and Critical Care Medicine (2020)

In conclusion, we agree that preterm-born subjects are not in a state of pending right heart failure, but they do show significant RV-PA uncoupling due to a combination of ventricular dysfunction and elevated RV afterload revealed by our analysis.We previously demonstrated the clinical relevance of this uncoupling by reporting reduced exercise tolerance in the subjects included in the current analysis (9).Furthermore, should these subjects follow the trajectory of progressive RV dysfunction identified in our animal model (10,11), careful clinical monitoring is warranted.Finally, we urge users of the gold-standard multibeat Ees/Ea ratio, as well as various singlebeat methods, to consider LV function in their physiological and clinical interpretations of RV-PA coupling.
Radiographic Parameters in Predicting Outcome of Patients with Hepatocellular Carcinoma (HCC) Treated with YTTRIUM-90 Microsphere Radioembolization (SIRT)
Authors: M. Salem, N. Jain, S. Taylor, G. Dyson, J. Beebe-Dimmer, I.P. Le, M. Choi, A.F. Shields, J.J. Critchfield, P.A. Philip
Journal: Annals of Oncology (2012)
P-0282 Facing Rectal Cancer Under the Age of 50: Analysis of 140 Patients Discussed in an Multidisciplinary Team (Co-Recto) in Argentina
Authors: Soledad Iseas, Marina Antelo, Mario Barugel, Ariel Aguilo, Marcela Carballido, Guillermo Mendez, Adriana Dieguez, Fabio Leiro, Martin Eleta, Mariana Coraglio, Juan Virginillo, Claudio Mospane, Enrique Roca
Journal: Annals of Oncology (2012)
INNO-206 is an Active Drug for Relapsed Advanced Soft Tissue Sarcoma
Authors: S. Chawla, V.S. Chua, A. Hendifar, D. Quon, S. Negre, K.N. Ganjoo, K. Sankhala, Y. Lavinski, S. Wieland, D. Levitt
Journal: Annals of Oncology (2012)