tbuckley/cabot-search huggingface dataset:
TCT CONNECT-319 Risk Stratification of All-Cause Mortality Using Resistive Reserve Ratio in Patients With No Obstructive Coronary Artery Disease
Authors: Takumi Toya, Ali Ahmad, Michel Corban, Ilke Ozcan, Faten Sebaali, Rajiv Gulati, Lilach Lerman, Amir Lerman
Journal: Journal of the American College of Cardiology (2020)
Use of 3D printer for face mask production to protect endoscopy unit personnel in contact with high-risk patients during COVID-19 pandemic
Authors: Federico De Grazia, Stefania Marconi, Marco Bardone, Aurelio Mauro, Gianluca Alaimo, Ferdinando Auricchio, Andrea Pietrabissa, Antonio Di Sabatino
Journal: Endoscopy (2020)

Endoscopy unit personnel are exposed to COVID-19 infection from inhalation of airborne droplets [1] [2]. Peri-endoscopic aerosolized infections have indeed been reported, making upper gastrointestinal endoscopy a high-risk procedure [3] [4]. In the current situation, infection prevention represents the only way to ensure the safety of both endoscopy unit personnel and patients. Whenever possible, patients who are considered at high risk or who have confirmed COVID-19 infection should undergo endoscopy in a negative-pressure room [5]. However, such a dedicated facility is not universally available to all endoscopy units, thus limiting the degree of preventive measures in most centers to protective clothing for endoscopists, specialist nurses, and technicians.
TCT CONNECT-231 Impact of Periprocedural Myocardial Injury on Long-term Cardiovascular Death After Chronic Total Occlusion Percutaneous Coronary Intervention
Authors: Lei Song, Shubin Qiao, Changdong Guan, Tongqiang Zou, Zhongwei Sun, Lihua Xie, Kefei Dou, Yida Tang, Weixian Yang, Yongjian Wu, Bo Xu
Journal: Journal of the American College of Cardiology (2020)
Abstract 13997: Racial Inequities in Hypertension Diagnosis: Non-Whites More Likely to Have Undiagnosed Hypertension
Authors: Kelly Gleason, Katharine Henry, Martha Abshire, Cheryl Dennison Himmelfarb
Journal: Circulation (2019)

Introduction: Despite established guidelines for diagnosis and treatment, almost 20 million adults with hypertension (HTN) in the US remain undiagnosed and untreated. Racial disparities exist in HT...
TCT CONNECT-432 Contrasted Area-Derived Septal Diameter for Alcohol Dose Determination in Alcohol Septal Ablation for HOCM
Authors: Eduardo Arias, Hugo Rodríguez-Zanella, Felix Damas De Los Santos, Gian Manuel Jiménez Rodríguez, Heriberto Ontiveros Mercado, Karen Arratia, Juan Sandoval-Jones, Alejandro Solorzano, Carlos Sandoval Santos, Guering Eid-Lidt
Journal: Journal of the American College of Cardiology (2020)
Accuracy of the Edinburgh Postnatal Depression Scale (EPDS) for screening to detect major depression among pregnant and postpartum women: systematic review and meta-analysis of individual participant data
Authors: Brooke Levis, Zelalem Negeri, Ying Sun, Andrea Benedetti, Brett D Thombs
Journal: BMJ (2020)

Abstract Objective To evaluate the Edinburgh Postnatal Depression Scale (EPDS) for screening to detect major depression in pregnant and postpartum women. Design Individual participant data meta-analysis. Data sources Medline, Medline In-Process and Other Non-Indexed Citations, PsycINFO, and Web of Science (from inception to 3 October 2018). Eligibility criteria for selecting studies Eligible datasets included EPDS scores and major depression classification based on validated diagnostic interviews. Bivariate random effects meta-analysis was used to estimate EPDS sensitivity and specificity compared with semi-structured, fully structured (Mini International Neuropsychiatric Interview (MINI) excluded), and MINI diagnostic interviews separately using individual participant data. One stage meta-regression was used to examine accuracy by reference standard categories and participant characteristics. Results Individual participant data were obtained from 58 of 83 eligible studies (70%; 15 557 of 22 788 eligible participants (68%), 2069 with major depression). Combined sensitivity and specificity was maximised at a cut-off value of 11 or higher across reference standards. Among studies with a semi-structured interview (36 studies, 9066 participants, 1330 with major depression), sensitivity and specificity were 0.85 (95% confidence interval 0.79 to 0.90) and 0.84 (0.79 to 0.88) for a cut-off value of 10 or higher, 0.81 (0.75 to 0.87) and 0.88 (0.85 to 0.91) for a cut-off value of 11 or higher, and 0.66 (0.58 to 0.74) and 0.95 (0.92 to 0.96) for a cut-off value of 13 or higher, respectively. Accuracy was similar across reference standards and subgroups, including for pregnant and postpartum women. Conclusions An EPDS cut-off value of 11 or higher maximised combined sensitivity and specificity; a cut-off value of 13 or higher was less sensitive but more specific. To identify pregnant and postpartum women with higher symptom levels, a cut-off of 13 or higher could be used. Lower cut-off values could be used if the intention is to avoid false negatives and identify most patients who meet diagnostic criteria. Registration PROSPERO (CRD42015024785).
COVID-19 and biologics in severe asthma: data from the Belgian Severe Asthma Registry
Authors: Shane Hanon, Guy Brusselle, Maud Deschampheleire, Renaud Louis, Alain Michils, Rudi Peché, Charles Pilette, Peter Rummens, Daniel Schuermans, Hélène Simonis, Olivier Vandenplas, Florence Schleich
Journal: European Respiratory Journal (2020)

<b>In a cohort of severe asthma patients, a small number of COVID-19 cases was found; none resulted in death or a very severe disease course. Use of biologics for severe allergic or severe eosinophilic asthma was not associated with a higher risk of COVID-19.</b>https://bit.ly/3ndZmyD
TCT CONNECT-216 Effects of the COVID-19 Pandemic on a Population Older Than 75 Years With Previous Percutaneous Coronary Revascularization: Experience in Spain and Portugal
Authors: Jose De la Torre Hernandez, Pilar Carrillo, Jesus Jimenez-Mazuecos, Alfonso Freites Esteves, Juan Gabriel Cordoba Soriano, Alejandro Gutierrez-Barrios, German Calle Perez, Belen Cid Alvarez, Ramiro Trillo, Tamara Garcia Camarero, Armando Perez de Prado, Juan Francisco Oteo Dominguez, Georgina Fuertes Ferre, Victor Alfonso Jimenez Diaz, Iñigo Lozano, Koldobika Garcia San Roman, Raymundo Ocaranza-Sanchez, Gines Martinez Caceres, Juan Sanchis Fores, Sílvio Leal, Xavier Carrillo, Alberto Rodrigues, Mario Sadaba, Imanol Otaegui, Esther Lazaro Fernandez, Jose Antonio Linares Vicente, Francisco J. Morales, Ricardo Santos, Francisco Bosa Ojeda
Journal: Journal of the American College of Cardiology (2020)
Overcoming MET-Dependent Resistance to Selective RET Inhibition in Patients with RET Fusion–Positive Lung Cancer by Combining Selpercatinib with Crizotinib
Authors: Ezra Y. Rosen, Melissa L. Johnson, Sarah E. Clifford, Romel Somwar, Jennifer F. Kherani, Jieun Son, Arrien A. Bertram, Monika A. Davare, Eric Gladstone, Elena V. Ivanova, Dahlia N. Henry, Elaine M. Kelley, Mika Lin, Marina S.D. Milan, Binoj C. Nair, Elizabeth A. Olek, Jenna E. Scanlon, Morana Vojnic, Kevin Ebata, Jaclyn F. Hechtman, Bob T. Li, Lynette M. Sholl, Barry S. Taylor, Marc Ladanyi, Pasi A. Jänne, S. Michael Rothenberg, Alexander Drilon, Geoffrey R. Oxnard
Journal: Clinical Cancer Research (2020)

Abstract Purpose: The RET proto-oncogene encodes a receptor tyrosine kinase that is activated by gene fusion in 1%–2% of non–small cell lung cancers (NSCLC) and rarely in other cancer types. Selpercatinib is a highly selective RET kinase inhibitor that has recently been approved by the FDA in lung and thyroid cancers with activating RET gene fusions and mutations. Molecular mechanisms of acquired resistance to selpercatinib are poorly understood. Patients and Methods: We studied patients treated on the first-in-human clinical trial of selpercatinib (NCT03157129) who were found to have MET amplification associated with resistance to selpercatinib. We validated MET activation as a targetable mediator of resistance to RET-directed therapy, and combined selpercatinib with the MET/ALK/ROS1 inhibitor crizotinib in a series of single patient protocols (SPP). Results: MET amplification was identified in posttreatment biopsies in 4 patients with RET fusion–positive NSCLC treated with selpercatinib. In at least one case, MET amplification was clearly evident prior to therapy with selpercatinib. We demonstrate that increased MET expression in RET fusion–positive tumor cells causes resistance to selpercatinib, and this can be overcome by combining selpercatinib with crizotinib. Using SPPs, selpercatinib with crizotinib were given together generating anecdotal evidence of clinical activity and tolerability, with one response lasting 10 months. Conclusions: Through the use of SPPs, we were able to offer combination therapy targeting MET-amplified resistance identified on the first-in-human study of selpercatinib. These data suggest that MET dependence is a recurring and potentially targetable mechanism of resistance to selective RET inhibition in advanced NSCLC.
STAT3-Mediated Astrocyte Reactivity Associated with Brain Metastasis Contributes to Neurovascular Dysfunction
Authors: Manuel Sarmiento Soto, James R. Larkin, Chris Martin, Alexandre A. Khrapitchev, Melissa Maczka, Vasiliki Economopoulos, Helen Scott, Carole Escartin, Gilles Bonvento, Sébastien Serres, Nicola R. Sibson
Journal: Cancer Research (2020)

Astrocytes are thought to play a pivotal role in coupling neural activity and cerebral blood flow. However, it has been shown that astrocytes undergo morphologic changes in response to brain metastasis, switching to a reactive phenotype, which has the potential to significantly compromise cerebrovascular function and contribute to the neurological sequelae associated with brain metastasis. Given that STAT3 is a key regulator of astrocyte reactivity, we aimed here to determine the impact of STAT3-mediated astrocyte reactivity on neurovascular function in brain metastasis. Rat models of brain metastasis and ciliary neurotrophic factor were used to induce astrocyte reactivity. Multimodal imaging, electrophysiology, and IHC were performed to determine the relationship between reactive astrocytes and changes in the cerebrovascular response to electrical and physiological stimuli. Subsequently, the STAT3 pathway in astrocytes was inhibited with WP1066 to determine the role of STAT3-mediated astrocyte reactivity, specifically, in brain metastasis. Astrocyte reactivity associated with brain metastases impaired cerebrovascular responses to stimuli at both the cellular and functional level and disrupted astrocyte-endothelial interactions in both animal models and human brain metastasis samples. Inhibition of STAT3-mediated astrocyte reactivity in rats with brain metastases restored cerebrovascular function, as shown by
Heterobifunctional PEG-grafted black phosphorus quantum dots: “Three-in-One” nano-platforms for mitochondria-targeted photothermal cancer therapy
Authors: Junyang Qi, Yue Xiong, Ke Cheng, Qi Huang, Jingxiu Cao, Fumei He, Lin Mei, Gan Liu, Wenbin Deng
Journal: Asian Journal of Pharmaceutical Sciences (2020)

Black phosphorus (BP) nano-materials, especially BP quantum dots (BPQDs), performs outstanding photothermal antitumor effects, excellent biocompatibility and biodegradability. However, there are several challenges to overcome before offering real benefits, such as poor stability, poor dispersibility as well as difficulty in tailoring other functions. Here, a "three-in-one" mitochondria-targeted BP nano-platform, called as BPQD-PEG-TPP, was designed. In this nano-platform, BPQDs were covalently grafted with a heterobifunctional PEG, in which one end was an aryl diazo group capable of reacting with BPQDs to form a covalent bond and the other end was a mitochondria-targeted triphenylphosphine (TPP) group. In addition to its excellent near-infrared photothermal properties, BPQD-PEG-TPP had much enhanced stability and dispersibility under physiological conditions, efficient mitochondria targeting and promoted ROS production through a photothermal effect. Both in vitro and in vivo experiments demonstrated that BPQD-PEG-TPP performed much superior photothermal cytotoxicity than BPQDs and BPQD-PEG as the mitochondria targeted PTT. Thus this "three-in-one" nanoplatform fabricated through polymer grafting, with excellent stability, dispersibility and negligible side effects, might be a promising strategy for mitochondria-targeted photothermal cancer therapy.
TCT CONNECT-77 Body Mass Index and Transcatheter Aortic Valve Replacement With Second-Generation Valves: Is it Really an Obesity Paradox?
Authors: Dillon Gurciullo, Saurav Chatterjee, Puneet Gandotra, Azhar Supariwala, Robert Kalimi, Rajiv Jauhar, Efstathia Mihelis, Luis Gruberg
Journal: Journal of the American College of Cardiology (2020)
TCT CONNECT-433 Catheter-Based Ventricular Restoration in Heart Failure Patients With Reduced LVEF: 3-Month Outcomes
Authors: Ulrich Jorde, Oleg Polonetsky, Alena Kurlianskaya, Petr Neuzil, Vivek Reddy, Azeem Latib, Kendra Grubb, Guilherme Silva, Dean Kereiakes, Satya Shreenivas, Daniel Burkhoff
Journal: Journal of the American College of Cardiology (2020)
TCT CONNECT-277 Slender IDS and Direct RX Sirolimus-Eluting Coronary Stents Utilizing a Novel PEA Bioresorbable Drug Carrier: Imaging Substudy Results From the OPTIMIZE IDE Trial
Authors: Shigeru Saito, Kenji Ando, Atsushi Hirohata, Akihiko Takahashi, Barry Bertolet, Pieter Stella, S. Chiu Wong, Sunil Rao, Dean Kereiakes
Journal: Journal of the American College of Cardiology (2020)
TCT CONNECT-351 Percutaneous Interventions for Recurrent Mitral Regurgitation After Surgical Repair: Decision-Making Algorithm and Long-Term Outcomes for MitraClip
Authors: Joe Aoun, Eleonora Avenatti, Neal Kleiman, Stephen Little, Colin Barker, Madiha Khan, Isaac Tea, G.M. Lawrie, Sachin Goel
Journal: Journal of the American College of Cardiology (2020)
Unbiased Screens Show CD8+ T Cells of COVID-19 Patients Recognize Shared Epitopes in SARS-CoV-2 that Largely Reside outside the Spike Protein
Authors: Andrew P. Ferretti, Tomasz Kula, Yifan Wang, Dalena M.V. Nguyen, Adam Weinheimer, Garrett S. Dunlap, Qikai Xu, Nancy Nabilsi, Candace R. Perullo, Alexander W. Cristofaro, Holly J. Whitton, Amy Virbasius, Kenneth J. Olivier, Lyndsey R. Buckner, Angela T. Alistar, Eric D. Whitman, Sarah A. Bertino, Shrikanta Chattopadhyay, Gavin MacBeath
Journal: Immunity (2020)
TCT CONNECT-381 Predictors of Ischemic and Bleeding Outcomes in High Bleeding Risk Patients Implanted With the SYNERGY Stent—A Post Hoc Analysis From the EVOLVE Short DAPT Study
Authors: Robert Yeh, Dean Kereiakes, Robert Stoler, Robert Feldman, Franz-Josef Neumann, Loukas Boutis, Naeem Tahirkheli, Ralph Toelg, Islam Othman, Bernardo Stein, Stephan Windecker, Harold Dauerman, Matthew Price, Paul Underwood, Dominic Allocco, Ian Meredith, Ajay Kirtane
Journal: Journal of the American College of Cardiology (2020)
TCT CONNECT-19 Base Camp to Everest Summit: Rapid Ascent of Artificial Intelligence Algorithms for ST-Elevation Myocardial Infarction Diagnosis
Authors: Sameer Mehta, Francisco Fernandez, Carlos Villagran, Daniel Vieira, Gladys Pinto, Samantha Quintero, Yogaraja Vijayan, Carmen Sanchez, Daniela Bou Daher, Camila Narváez-Caicedo
Journal: Journal of the American College of Cardiology (2020)
TCT CONNECT-287 Treatment of Patients With Recurrent In-Stent Restenosis Who Failed Intravascular Brachytherapy
Authors: Charan Yerasi, Brian Case, Brian Forrestal, Corey Shea, Cheng Zhang, Itsik Ben-Dor, Lowell Satler, Ron Waksman
Journal: Journal of the American College of Cardiology (2020)
Video consultations in primary and specialist care during the covid-19 pandemic and beyond
Authors: Josip Car, Gerald Choon-Huat Koh, Pin Sym Foong, C Jason Wang
Journal: BMJ (2020)

What you need to know• Video consultations in healthcare present an approximation of face-to-face interaction and are a "visual upgrade" of widely used telephone consultations • Evidence for the effectiveness of video consultations is scarce, but points towards effectiveness, safety, and high satisfaction in patients and healthcare providers • Be prepared to switch from a video to a telephone or in-person consultation, depending on technical, patient, or clinical factorsEven before the covid-19 pandemic, virtual consultations (also called telemedicine consultations) were on the rise, with many healthcare systems advocating a digital-first approach. 1 -7 At the start of the pandemic, many GPs and specialists turned to video consultations to reduce patient flow through healthcare facilities and limit infectious exposures. 8 -16 Video and telephone consultations also enable clinicians who are well but have to self-isolate, or who fall into high risk groups and require shielding, to continue providing medical care. 17 -19 The scope for video consultations for long term conditions is wide and includes management of diabetes, hypertension, asthma, stroke, psychiatric illnesses, cancers, and chronic pain. 20 -22 Video consultations can also be used for triage and management of a wide range of acute conditions, including, for example, emergency eye care triage. 23 -25 This practice pointer summarises the evidence on the use of video consultations in healthcare and offers practical recommendations for video consulting in primary care and outpatient settings.
TCT CONNECT-92 Initial Single-Center Experience With Transfemoral Transcatheter Aortic Valve Replacement in Patients With Symptomatic Severe Aortic Regurgitation
Authors: Shawn Gogia, Torsten Vahl, Omar Khalique, Nadira Hamid, Sarah Borden, Christine Chung, Vivian Ng, Amisha Patel, Isaac George, Rebecca Hahn, Martin Leon, Susheel Kodali
Journal: Journal of the American College of Cardiology (2020)
Rapid Adaptation of HIV Treatment Programs in Response to COVID-19 — Namibia, 2020
Authors: Steven Y. Hong, Laimi S.N. Ashipala, Leonard Bikinesi, Ndapewa Hamunime, Jacques W.N. Kamangu, Ashley Boylan, Edwin Sithole, Ismelda C. Pietersen, Gram Mutandi, Catherine McLean, Eric J. Dziuban
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

Namibia is an upper-middle income country in southern Africa, with a population of approximately 2.5 million (1). On March 13, 2020, the first two cases of coronavirus disease 2019 (COVID-19) in Namibia were identified among recently arrived international travelers. On March 17, Namibia's president declared a state of emergency, which introduced measures such as closing of all international borders, enactment of regional travel restrictions, closing of schools, suspension of gatherings, and implementation of physical distancing measures across the country. As of October 19, 2020, Namibia had reported 12,326 laboratory-confirmed COVID-19 cases and 131 COVID-19-associated deaths. CDC, through its Namibia country office, as part of ongoing assistance from the U.S. President's Emergency Plan for AIDS Relief (PEPFAR) provided technical assistance to the Ministry of Health and Social Services (MoHSS) for rapid coordination of the national human immunodeficiency virus (HIV) treatment program with the national COVID-19 response.
TCT CONNECT-339 Symptomatic Improvement Is Predictive for Improved Long-Term Survival After Transcatheter Mitral Valve Edge-to-Edge Repair
Authors: Martin Geyer, Karsten Keller, Michaela Hell, Tobias Ruf, Felix Kreidel, Alexander Tamm, Aniela Petrescu, Sonja Born, Kevin Bachmann, Andres Beiras-Fernandez, Eberhard Schulz, Thomas Münzel, Ralph Stephan von Bardeleben
Journal: Journal of the American College of Cardiology (2020)
A blinded, multirater and multi-institutional study evaluating the Objective Structured Assessment of Technical Skills (OSATS) tool in dermatology education
Authors: Kristina Navrazhina, None Murad Alam, Rebecca Tung, Brienne D. Cressey, Ashley Decker, David Surprenant, Cindy E. Parra, Emily Poon, Wendy Kim, Kira Minkis
Journal: Journal of the American Academy of Dermatology (2020)
TCT CONNECT-444 Feasibility and Safety of Left Atrial Appendage (LAA) Occlusion in Presence of LAA Thrombus: The TRAPEUR Registry (Thrombus Trapping European Registry)
Authors: Frederic Sebag, Roberto Galea, Antoine Lepillier, Ghassan Moubarak, Arthur Darmon, Lorenz Raber, Nicolas Amabile
Journal: Journal of the American College of Cardiology (2020)
The effect of ethanol on asialoglycoprotein receptor-mediated phagocytosis of apoptotic cells by rat hepatocytes
Authors: Benita L. McVicker, Dean J. Tuma, Jacy A. Kubik, Agnes M. Hindemith, Cheryl R. Baldwin, Carol A. Casey
Journal: Hepatology (2002)

Apoptotic cell death is a well-defined process that is controlled by intrinsic cellular mechanisms followed by the generation of apoptotic bodies and their subsequent rapid elimination through the action of phagocytic cells. Within the liver, the asialoglycoprotein receptor (ASGP-R) has been shown to be involved in the phagocytosis of apoptotic hepatocytes, as well as altered cellular endocytic events after ethanol administration. The goal of the present study was to further clarify the capacity of ASGP-R to phagocytose apoptotic cells in relationship to the damaging events that occur with alcohol consumption. For these experiments, we used an in vitro suspension assay coupled with flow cytometry to measure apoptotic cell engulfment by rat hepatocytes after chronic ethanol administration. The results of this assay indicated that the phagocytosis of apoptotic cells was decreased significantly (30% to 42%, P &lt; 0.05) in the presence of antibody specific for ASGP-R as well as the introduction of competing sugars in the media. In addition, uptake of apoptotic cells was impaired by 40% to 60% ( P &lt; 0.05) in cells obtained from ethanol-fed animals as compared with controls. In conclusion, the ASGP-R is involved in the recognition and uptake of apoptotic cells and this process is altered significantly by ethanol treatment. These findings may play a role in a better understanding of the clinical manifestations of alcohol-induced liver injury as altered uptake of apoptotic cells via ASGP-R may result in the release of proinflammatory mediators, the introduction of autoimmune responses, and inflammatory injury to the tissue. (Hepatology2002;36:1478-1487).
TCT CONNECT-423 Effect of Combined Renal Denervation and Pulmonary Vein Isolation in Atrial Fibrillation Recurrence in Drug-Resistant Hypertension: A Meta-Analysis
Authors: Jairus Adrian Flores, Mark Terence Mujer, Bin Rashid Chin, Christopher Garces, Ardy Fenando, Ahmad Elshafie, Osama Mosalem, Samanjit Kandola, Si Yuan Khor, Kai Chen
Journal: Journal of the American College of Cardiology (2020)