tbuckley/cabot-search huggingface dataset:
The Proteasome Inhibitor BSc2118 Causes Growth Inhibition, Cell Cycle Arrest and Cyclin D1 Degradation in Mantle Cell Lymphoma Cell Lines.
Authors: Christian Jakob, Jan Sterz, Ivana von Metzler, Ulrike Kuckelkorn, Hannes A. Braun, Susanne Rötzer, Martin Kaiser, Ulrike Heider, Jessica Rademacher, Peter M. Kloetzel, Orhan Sezer
Journal: Blood (2007)
JQ1, a c-MYC Inhibitor Targets Hexokinase II and Enhances the Cytotoxic Effects of Chemotherapeutic Agents in Diffuse Large B-Cell Lymphoma (DLBCL)
Authors: Juan J Gu, Matthew J. Barth, Qunling Zhang, Cory Mavis, Francisco J. Hernandez-Ilizaliturri
Journal: Blood (2016)
Multivalent Anti-CD20/Anti-CD22 Bispecific Antibody Fusion Proteins Made by the DNL Method Show Potent Lymphoma Cytotoxicity.
Authors: Edmund A. Rossi, Michele J. Losman, Diane L. Nordstrom, Thomas Cardillo, Meiyu Loo, John Kopinski, Zhengxing Qu, David M. Goldenberg, Chien-Hsing Chang
Journal: Blood (2006)
Is Complicated Celiac Disease or Refractory Sprue an Intestinal Intra-Epithelial Cryptic T-Cell Lymphoma?
Authors: Nicole Brousse, Virginie Verkarre, Natacha Patey-Mariaud de Serre, Christophe Cellier, Nadine Cerf-Bensussan, Eric Delabesse, Elisabeth Macintyre
Journal: Blood (1999)
Reduced Relapse Risk in Acute Myelogenous Leukemia (AML) after Allogeneic Hematopoietic Stem Cell Transplantation (HCT) in Patients Who Experienced CMV Reactivation: Influence of Donor KIR Genotypes
Authors: Anthony Stein, Ketevan Gendzekhadze, Joycelynne Palmer, Ni-Chun Tsai, Sandra H. Thomas, Stephen J. Forman, John A. Zaia, David Senitzer, Ryotaro Nakamura
Journal: Blood (2014)
Effects of tesamorelin on non-alcoholic fatty liver disease in HIV: a randomised, double-blind, multicentre trial
Authors: Takara L Stanley, Lindsay T Fourman, Meghan N Feldpausch, Julia Purdy, Isabel Zheng, Chelsea S Pan, Julia Aepfelbacher, Colleen Buckless, Andrew Tsao, Anela Kellogg, Karen Branch, Hang Lee, Chia-Ying Liu, Kathleen E Corey, Raymond T Chung, Martin Torriani, David E Kleiner, Colleen M Hadigan, Steven K Grinspoon
Journal: The Lancet HIV (2019)
Salmonella enteritidis infections associated with foods purchased from mobile lunch trucks--Alberta, Canada, October 2010-February 2011.
Authors: Lance Honish, Dawn Greenwald, Kristin McIntyre, Wendy Lau, Sarah Nunn, Dale Nelson, Judy MacDonald, Victoria Keegan, Krista Wilkinson
Journal: MMWR Morbidity and Mortality Weekly Report (2013)
Patients with Chronic Lymphocyte Leukemia (CLL) Have Naturally Occurring Antibodies Against the Receptor Tyrosine Kinase (ROR1)
Authors: Mohammad Hojjat-Farsangi, Fariba Mozaffari, Amir Hossein Daneshmanesh, Anders Osterborg, Fazel Shokri, Håkan Mellstedt
Journal: Blood (2011)
Longitudinal analysis of the effect of water hardness on atopic eczema: evidence for gene–environment interaction
Authors: Z.K. Jabbar‐Lopez, J. Craven, K. Logan, D. Greenblatt, T. Marrs, S. Radulovic, W.H.I. McLean, G. Lack, D.P. Strachan, M.R. Perkin, J.L. Peacock, C. Flohr
Journal: British Journal of Dermatology (2019)

Background Several studies have identified an association between water hardness and atopic eczema (AE); however, there is a paucity of longitudinal data in early life. Objectives To examine whether water hardness is associated with an increased risk of AE and skin barrier dysfunction in infants and to assess effect modification by filaggrin (FLG) loss-of-function variants. Methods We performed a longitudinal analysis of data from infants in the Enquiring About Tolerance (EAT) study, who were enrolled at 3 months and followed up until 36 months of age. Results Of 1303 infants enrolled in the EAT study, 91·3% (n = 1189) attended the final clinic visit and 94·0% (n = 1225) of participants' families completed the 36-month questionnaire. In total, 761 (58·4%) developed AE by 36 months. There was no overall association between exposure to harder (> 257 mg L−1 CaCO3) vs. softer (≤ 257 mg L−1 CaCO3) water: adjusted hazard ratio (HR) 1·07, 95% confidence interval (CI) 0·92–1·24. However, there was an increased incidence of AE in infants with FLG mutations exposed to hard water (adjusted HR 2·72, 95% CI 2·03–3·66), and statistically significant interactions between hard water plus FLG and both risk of AE (HR 1·80, 95% CI 1·17–2·78) and transepidermal water loss (0·0081 g m−2 h−1 per mg L−1 CaCO3, 95% CI 0·00028–0·016). Conclusions There is evidence of an interaction between water hardness and FLG mutations in the development of infantile AE. Linked Comment: Arents and Leonardi-Bee. Br J Dermatol 2020; 183:203–204.
Acute Leukemia of Ambiguous Lineage: A Comprehensive Survival Analysis Enables Designing New Treatment Strategies
Authors: Ondrej Hrusak, Valerie De Haas, Ales Luks, Iveta Janotova, Ester Mejstrikova, Kirsten Bleckmann, Anja Moricke, Julie Irving, Benigna Konatkowska, Thomas B. Alexander, Hiroto Inaba, Kjeld Schmiegelow, Simone Stokley, Jorge Gabriel Rossi, Maria Sara Felice, Luciano Dalla-Pozza, Jessa Morales, Michael Dworzak, Barbara Buldini, Giuseppe Basso, Myriam Campbell, Maria Elena Cabrera, Neda Marinov, Sarah Elitzur, Shai Izraeli, Drorit Luria, Tamar Feuerstein, Alexandra Kolenova, Peter Svec, Elena Kreminska, Karen R. Rabin, Sophia Polychronopoulou, Elaine da Costa, Hanne Vibeke Marquart, Antonis Kattamis, Richard Ratei, Dirk Reinhardt, Anthony V Moorman, Martin Schrappe, Jan Stary
Journal: Blood (2016)
Genetic Subtypes of Human Pediatric ALLs Show Gene Expression Differences That Parallel Those Observed in Mouse B1 and B2 Progenitors, Suggesting Divergent Developmental Origins
Authors: Scott C. Kogan, Huimin Geng, Ritu Roy, Encarnacion Montecino-Rodriguez, Coline M Gaillard, Kamir Hiam, Henrik Bengtsson, David Casero, Adam B Olshen, Kenneth Dorshkind
Journal: Blood (2016)
Impact of Single Nucleotide Polymorphisms in Genes Involved in DNA Repair and Drug Metabolism On Survival After Autologous Stem Cell Transplantation in Patients with Multiple Myeloma.
Authors: Carlos Fernández de Larrea, Alfons Navarro, Natalia Tovar, Fabiola Pedrosa, Tania Díaz, María Teresa Cibeira, Laura Magnano, Laura Rosiñol, Montserrat Rovira, María Rozman, Mariano Monzó, Joan Blade
Journal: Blood (2012)
Increase of Regulatory γδ T Cells Reduces the Incidence of Acute Graft-Versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation
Authors: Li Gao, Li Xuan, Xiuli Wu, Zhiping Fan, Fen Huang, Zhangshan Yi, Yangqiu Li, Qifa Liu
Journal: Blood (2016)
Transition out of HSC Dormancy By a Continuous Upregulation of Metabolism Is Controlled Via Dietary Vitamin A/ Retinoic Acid Signaling
Authors: Nina Cabezas-Wallscheid, Florian Buettner, Daniel Klimmeck, Pia Sommerkamp, Luisa Ladel, Frederic B Thalheimer, Simon Renders, Daniel Pastor, Leticia Roma, Petra Zeisberger, Adriana Przybylla, Roberta Scognamiglio, Sandro Altamura, Carolina M. Florian, Malak Fawaz, Dominik Vonficht, Paul Collier, Dinko Pavlinik, Hartmut Geiger, Timm Schröder, Vladimir Benes, Tobias P. Dick, Michael A Rieger, Oliver Stegle, Andreas Trumpp
Journal: Blood (2016)
Extracorporeal Photopheresis (ECP) As Part of Combined Effective Immunotherapy Treatment of Graft-Versus-Host Disease
Authors: Tatyana Bykova, Andrey Kozlov, Maria Estrina, Natalia V Stancheva, Elena V Semenova, Ludmila S Zubarovskaya, Boris V Afanasyev, Axel R. Zander
Journal: Blood (2012)
Asparaginase-Associated Myelosuppression and Effects on Dosing of Other Chemotherapeutic Agents In Children and Adolescents with Acute Lymphoblastic Leukemia
Authors: Reid Merryman, William J. Gostic, Kristen E. Stevenson, Donna Neuberg, Jane O'Brien, Stephen E. Sallan, Lewis B. Silverman
Journal: Blood (2010)
Denosumab for Treatment of Hypercalcemia of Malignancy in Patients with Solid Tumors or Hematological Malignancies Refractory to IV Bisphosphonates: A Single-Arm Multicenter Study
Authors: Mimi I Hu, Rasim Gucalp, Karl Insogna, Ilya Glezerman, Sophie Leboulleux, Waldemar Misiorowski, Bennett Yu, Wendy Ying, Howard S. Yeh
Journal: Blood (2011)
Regarding epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux
Authors: Jeanne-Marie Perotin, Ratko Djukanovic, Donna E. Davies
Journal: European Respiratory Journal (2019)

We thank C. Ward and Z.J. Kharaba for their interesting comments on the OGP endotype of severe asthma that we recently described [1]. OGP phenotype is not characterised by obstructive sleep apnoea <http://bit.ly/2kv2CKE>
Prophylaxis in Patients with Hemophilia a and Its Impact on Quality of Life Using the Specific Index Haem-a-Qol at a Hospital in Paraguay
Authors: Cristobal A Frutos, Barbara Konkle, Jorge Batista, Silvia Brizuela, Elvira Enciso, Gustavo Fernandez, Adolfo Gaona, Helga Martinez, Alma M Poisson, Marlene Rivarola
Journal: Blood (2016)
Abstract 15552: Insulin-Like Growth Factor-1 is Lower in Acute Stroke but is Not Related to Recovery
Authors: Anna E Mattlage, Michael Rippee, Janice Sandt, Sandra A Billinger
Journal: Circulation (2015)

Purpose: Insulin-like growth factor 1 (IGF1) sampled within ten days of stroke has resulted in inconsistent findings. When compared to control participants, one study found elevated levels of IGF1 while another reported lower values. Despite these reported differences, there is evidence to suggest that IGF1 may have a neuroprotective effect and may be related to admitting stroke severity and functional independence at one month post-stroke. The possibility exists that a large sampling window and no consideration for insulin-like growth factor binding protein 3 (IGFBP3), may account for the differing results. The purpose of this study was to: 1) determine the difference in IGF1, IGFBP3, and IGF1 ratio in individuals with acute stroke and controls; and 2) determine the relationship of IGF1, IGFBP3, and IGF1 ratio to admission stroke severity and functional independence at one month post stroke. Methods: Blood was collected from 12 individuals with a diagnosis of acute stroke (4 males; 63.9 + 8.4 years) between 7:30 and 9:00 am, after an overnight fast, and within 72 hours of hospital admission. Blood was obtained from 12 age and gender matched healthy controls (4 males; 64.8 + 9.8 years) after an overnight fast during similar hours. Plasma was obtained from blood samples, aliquoted, and frozen within 1 hour of collection. IGF1 and IGFBP3 were quantified using standard procedure ELISAs (Alpco, Salem, NH). Admission NIH Stroke Scale and the modified Rankin Scale (mRS) at one month post stroke was obtained from the electronic medical record. Results: IGF1 (stroke: 113 ng/mL; control: 123 ng/mL, p = .59) and IGFBP3 (stroke: 2350 ng/mL; control: 2593 ng/mL, p = .33) were lower in the acute stroke patients, but not significantly. IGF1 ratio was not different (stroke: .06; control: 05; p = .55) in acute stroke compared to controls. There were no significant relationships between any IGF marker and stroke severity (p &gt; 0.50), nor mRS (p &gt; 0.50). Conclusion: We report that IGF1 and IGFBP3 is lower in acute stroke patients. A single time point of IGF1 and IGFBP3 during acute stroke may not demonstrate a neuroprotective relationship to stroke recovery. Future work should examine percent change in the IGF family to determine whether this may be a more valuable biomarker of stroke recovery.
Human Atheromatous Plaques Stimulate Thrombus Formation by Activating Platelet Glycoprotein VI.
Authors: Armin J. Reininger, Richard Brandl, Sandra Penz, Pankaj Goyal, Tamer Rabie, Enno Rother, Christine Goetz, Bernd Engelmann, Richard Farndale, Bernhard Nieswandt, Wolfgang Siess
Journal: Blood (2004)
Expanded Access Program (EAP) for Lenalidomide (Revlimid®) Plus Dexamethasone in over 1400 Subjects with Relapsed or Refractory Multiple Myeloma.
Authors: Christine Chen, Donna E. Reece, David Siegel, Ruben Niesvizky, Ralph Vincent Boccia, Edward A. Stadtmauer, Rafat Abonour, David Irwin, Jonathan Polikoff, Shaji Kumar, Richard A. Gams, Laurie Kenvin, Dale McElveen, Angela Hu, Dennis Pietronigro, Robert D. Knight, Jerome B. Zeldis
Journal: Blood (2006)
Role of Allogeneic Stem Cell Transplantation in Lymphoplasmacytic Lymphoma. Analysis of 61 Cases from the European Bone Marrow Registry (EBMT).
Authors: Charalampia A. Kyriakou, Anthony H. Goldstone, Anna Sureda, Kwee Yong, Goli Taghipour, Carmen Ruiz de Elvira, David C. Linch, Stephen Mackinnon, Norbert Schmitz
Journal: Blood (2004)
Identification of Multiple HLA Class II Epitopes of Aspergillus Fumigatus by Generation of CD4+ T Cell Clones Recognizing the A. Fumigatus proteins Crf1 and Catalase1
Authors: Hetty Jolink, Els van Oorschot, Ed J Kuijper, Jan Willem Drijfhout, Jaap T van Dissel, J.H.Frederik Falkenburg, Mirjam H.M. Heemskerk
Journal: Blood (2010)
Chimeric Antigen Receptor Modified T Cells Directed Against CD19 (CTL019 cells) Have Long-Term Persistence and Induce Durable Responses In Relapsed, Refractory CLL
Authors: David L. Porter, Michael Kalos, Noelle V. Frey, Stephan A. Grupp, Alison W. Loren, Christina Jemison, Joan Gilmore, Holly McConville, James Capobianchi, Lester Lledo, Anne Chew, Zhaohui Zheng, Bruce L. Levine, Carl H. June
Journal: Blood (2013)
Mutant Splicing Factor 3b Subunit 1 (SF3B1) Causes Dysregulated Erythropoiesis and a Stem Cell Disadvantage
Authors: Esther A. Obeng, Marie E. McConkey, Dean Campagna, Rebekka K. Schneider, Michelle C. Chen, Paul J Schmidt, Ann Mullally, Mark D. Fleming, Benjamin L. Ebert
Journal: Blood (2014)
Clinical, Cellular and Molecular Differences Between Newly Diagnosed and Relapsed Patients with Acute Promyelocytic Leukemia: Insights Into Mechanisms of Resistance
Authors: Ezhilarasi Chendamarai, Ansu Abu Alex, Saravanan Ganesan, Vandana Kamath, Sukesh C Nair, Nancy Beryl Janet, Vivi M Srivastava, Kavitha M Lakshmi, Poonkuzhali Balasubramanian, Rayaz Ahmed, Aby Abraham, Auro Viswabandya, Biju George, Alok Srivastava, Vikram Mathews
Journal: Blood (2012)
Signal detection of chemotherapy-related cardiac dysfunction on small molecule tyrosine kinase inhibitors
Authors: Takahito Mizuno, Takamasa Sakai, Kouichi Tanabe, Koji Kozaki, Takumi Umemura, Mari Hotta, Tomohiro Kajiguchi, Tomoki Kimura, Sigehiro Takami, Fumiko Ohtsu
Journal: Annals of Oncology (2019)
Persistently Increased Creatine Kinase Levels in Patients with Chronic Myeloid Leukemia Treated with Imatinib Correlate with Major Cytogenetic Remission.
Authors: Haifa K. Al-Ali, Rainer Krahl, Mathias Orth, Silke Perlowski, Sandra Otto, Michael W. Deininger, Dietger Niederwieser
Journal: Blood (2004)
Genome-Wide CRISPR/Cas9 Screen Reveals That the Dcps Scavenger Decapping Enzyme Is Essential for AML Cell Survival
Authors: Takuji Yamauchi, Takeshi Masuda, Matthew C. Canver, Michael Seiler, Mohammad Shboul, Manami Maeda, Vivien Schoonenberg, Mitchel A. Cole, Claudio Macias-Trevino, Yuichiro Semba, Yuichi Ishikawa, Michitaka Nakano, Fumio Arai, Stuart Orkin, Bruno Reversade, Silvia Buonamici, Luca Pinello, Koichi Akashi, Daniel E. Bauer, Takahiro Maeda
Journal: Blood (2017)
A Phase 2/3 Multicenter, Randomized Study Comparing the Efficacy and Safety of Lenalidomide Versus Investigator’s Choice in Relapsed/Refractory DLBCL
Authors: Myron S. Czuczman, Andrew Davies, Kim M Linton, Nina Wagner-Johnston, Randy D. Gascoyne, David A. Eberhard, Gilles Salles, Thomas E. Witzig, Pier Luigi Zinzani, George W. Wright, Louis M. Staudt, Jacqueline Repici, Dale Song, Oliver Manzke, Ian D Lewis
Journal: Blood (2014)
Targeting NF-κB and Induction of Apoptosis by Dehydroxymethylepoxyquinomicin (DHMEQ) in Multiple Myeloma Cells.
Authors: Yoshitaka Miyakawa, Kanoko Kohmura, Kaori Saito, Hiroshi Yoshida, Asako Ikejima, Yutaka Hattori, Yasuyuki Ohnishi, Masato Nakamura, Yasuo Ikeda, Kazuo Umezawa, Masahiro Kizaki
Journal: Blood (2004)
Ageing workforce: sustaining the “longevity dividend”
Authors: Desmond J O’Neill
Journal: BMJ (2019)

An aspect often missed in discourse on ageing and the workforce,1 is the benefit of maturity to the workplace.2 The exemplar is Captain Chesley Sullenberger: despite slower reaction times than younger pilots, his experience and maturity were critical to the safe landing of his disabled airliner on the Hudson river. This “longevity dividend” is replicated …
Dasatinib (SPRYCEL®) in Patients (pts) with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Who Are Imatinib-Resistant (im-r) or -Intolerant (im-i): Updated Results from the CA180-015 ‘START-L’ Study.
Authors: Herve Dombret, O.G. Ottmann, G. Rosti, B. Simonsson, R.A. Larson, A. Gollerkeri, A. Apanovitch, J. Radich, Steven Coutre
Journal: Blood (2006)
A Comparison Between Next-Generation Sequencing and ASO-qPCR For Minimal Residual Disease Detection In Multiple Myeloma: The Clinical Value In ASCT Setting
Authors: Hiroyuki Takamatsu, Ryoichi Mura, Jianbiao Zheng, Martin Moorhead, Terasaki Yasushi, Yoshida Takashi, Malek Faham, Shinji Nakao
Journal: Blood (2013)
Microenvironment Regulation of IL23R/IL-23 Axis Drives Chronic Lymphocytic Leukemia (CLL) Progression
Authors: Fortunato Morabito, Giovanna Cutrona, Anna Grazia Recchia, Marina Fabbi, Silvano Ferrini, Massimo Gentile, Ernesto Vigna, Monica Colombo, Carlotta Massucco, Sabrina Bossio, Laura De Stefano, Ugo Consoli, Iolanda D. Vincelli, Caterina Musolino, Stefano Molica, Antonino Neri, Claudio Tripodo, Manlio Ferrarini
Journal: Blood (2015)
Multicenter Experience of High Dose Chemotherapy (HDCT)+Autologous Stem Cell Transplantation (ASCT) in Multiple Sclerosis (MS) Patients.
Authors: Yury L. Shevchenko, Andrei A. Novik, Alexey N. Kuznetcov, Boris V. Afanasiev, Igor A. Lisukov, Oleg A. Rykavicin, Alexandr A. Myasnikov, Tatiana I. Ionova, Sergey V. Shamanski, Andrey D. Kulagin, Olga A. Malysheva, Nikolay I. Baziy, Vladimir Y. Melnichenko, Denis A. Fedorenko, Inna V. Vereschagina, Andrey E. Zdorov, Anton V. Kishtovich, Roman A. Ivanov, Yury N. Fedotov, Gary I. Gorodokin
Journal: Blood (2006)
Blastic Plasmacytoid Dendritic Cell Neoplasm: Report of Three Cases.
Authors: Paola Carluccio, Mario Delia, Anna Mestice, Domenico Pastore, Alessandra Ricco, Annamaria Giordano, Tommasina Perrone, Francesco Gaudio, Vincenzo Liso, Giorgina Specchia
Journal: Blood (2009)
Nilotinib Is Safe and Effective in Accelerated Phase Chronic Myelogenous Leukemia (CML-AP) Patients with Imatinib Resistance or Intolerance.
Authors: Philipp le Coutre, Francis J. Giles, Jane Apperley, Oliver G. Ottmann, Norbert Gattermann, Stephen G. O’Brien, Kazimierz Kuliczkowski, Richard A. Larson, Dong-Wook Kim, Ariful Haque, Neil Gallagher, Michele Baccarani, Hagop M. Kantarjian
Journal: Blood (2007)
A Comprehensive Genomic Approach Using Gain of Function Cell Models, Patient Specimens and ChIP-on-CHIP Technologies Identifies PLZF-RARα Target Genes with Potential Roles in t(11;17) Associated APL.
Authors: Jonathan D. Licht, Kim L. Rice, Itsaso Hormaeche, Julia Meyer, Ken I. Mills, David Grimwade
Journal: Blood (2007)
AML Specific Targeted Drugs Identified By Drug Sensitivity and Resistance Testing: Comparison of Ex Vivo Patient Cells with in Vitro Cell Lines
Authors: Disha Malani, Astrid Murumägi, Bhagwan Yadav, Tea Pemovska, John Patrick Mpindi, Mika Kontro, Tero Aittokallio, Caroline A Heckman, Kimmo Porkka, Krister Wennerberg, Maija Wolf, Olli Kallioniemi
Journal: Blood (2014)
A Genome Wide shRNA Screen In Primary Human AML Cells Identifies ROCK1 As a Novel Therapeutic Target
Authors: Martin Wermke, Aylin Camgoz, Maciej Paszkowski-Rogacz, Sebastian Thieme, Malte von Bonin, Andreas Dahl, Mirko Theis, Gerhard Ehninger, Sebastian Brenner, Martin Bornhäuser, Frank Buchholz
Journal: Blood (2013)
Activation of Oxidative Stress and Down-Regulation of Nuclear Factor Erythroid 2-Related Factor May Be Responsible for Disulfiram/Copper Complex Induced Apoptosis in Lymphoid Malignancy Cell Lines
Authors: Feili Chen, Jie Zha, Yanyan Zhang, Pengcheng Shi, Xutao Guo, Shiyun Wang, Weiguang Wang, Bing Xu
Journal: Blood (2012)
Acute Myeloblastic Leukemia Relapse after Allogeneic Stem Cell Transplantation
Authors: Mediavilla Clémence, Stéphane Vigouroux, Reza Tabrizi, Laurence Clement, Anne Banos, Pascal Turlure, Xavier Lafarge, Pierre-Yves Dumas, Thibaut Leguay, Arnaud Pigneux, Noel Milpied, Edouard Forcade
Journal: Blood (2018)
Treatment patterns in metastatic colorectal cancer (mCRC) in Slovakia.
Authors: Tomas Salek, Peter Pichna
Journal: Journal of Clinical Oncology (2013)

e14700 Background: CRC is one of the most frequent malignant diseases in Slovakia. Slovakia with approximately 5 million inhabitants is country with the highest incidence of CRC in Europe, and there is a focus on CRC treatment within Slovak healthcare system. Methods: Between March 2012 and June 2012 we made a survey in the vast majority of hospital medical oncology departments and outpatient cancer clinics /93 facilities- it comprises approximately 95 % of Slovak departments and clinics treating metastatic CRC/. Data obtained during this 4months period were then multiplied by 3, and that gave us the approximate yearly data. (We reviewed data from 532 patients during four months period.) Results: 670 newly diagnosed mCRC patients (pts) (38%) were treated with chemotherapy alone in the first line, 867 pts (48%) with chemotherapy plus biologics and 231 pts (13%) were treated with best supportive care only. 87% of our newly diagnosed mCRC pts were treated with first line therapy, 37% with second line therapy and 25% with third and later lines of treatment. 42% of pts had KRAS status examined with following results: 44% KRAS wild type, 50.4% KRAS mutated and 5.6% status unknown. Conclusions: We conclude that in Slovakia we have similar patterns of mCRC treatment like in other Middle European countries and high percentage of pts in the first line is treated with biologic therapy.
Osteoblast Differentiation of Stromal Cells Induced By Leukemic Cells
Authors: Saravanan Ganesan, Hamenth Kumar Palani, Vairavan Lakshmanan, Nithya Balasundaram, Ansu Abu Alex, Sachin David, Biju George, Poonkuzhali Balasubramanian, Neha Vyas, Dasaradhi Palakodeti, Vikram Mathews
Journal: Blood (2016)
An Animal Model for Assessing Cardiovascular Cell Therapy with Human Bone Marrow Stem Cells
Authors: Cristina Touriño, Mariana Di Doménico, Carlos Rodríguez, Sebastián Adó, Rodolfo Ferrando, Carmen Bolatto, Gabriel Anesetti, Milka Radmilovich, Ana Mariño, Ana Panuncio, Alejandro Benech, Verónica Di Mauro, Gabriel Lorier
Journal: Blood (2010)
Graft-Specific HLA-Antibodies Do Not Influence Unit Dominance and Do Not Prevent High Rates of Sustained Donor Engraftment in Recipients of Double-Unit Cord Blood Transplantation
Authors: Parastoo B Dahi, Jonathan Barone, Susan Hsu, Courtney Byam, Marissa N Lubin, Katherine L Evans, Doris M Ponce, Sergio A. Giralt, Nancy A. Kernan, Andromachi Scaradavou, Juliet N Barker
Journal: Blood (2012)
The Prognostic Value of Interim PET Scan in Patients with Classical Hodgkin Lymphoma
Authors: Yasuhiro Oki, Hubert Chuang, Beth Chasen, Tinsu Pan, Michelle A. Fanale, Bouthaina S. Dabaja, Nathan H Fowler, Jorge Enrique E Romaguera, Luis E Fayad, Fredrick B Hagemeister, Alma Rodriguez, Sattva S. Neelapu, Felipe Samaniego, Larry W Kwak, Anas Younes
Journal: Blood (2012)
PD-1 Inhibits TCR Proximal Signaling By Sequestering SHP-2 Phosphatase and Facilitating Csk-Mediated Inhibitory Phosphorylation of Lck
Authors: Kankana Bardhan, Nikolaos Patsoukis, Duygu Sari, Theodore Anagnostou, Pranam Chatterjee, Gordon J. Freeman, Lequn Li, Vassiliki A. Boussiotis
Journal: Blood (2015)
Alterations of the Bone Marrow Stromal Microenvironment in Adult Patients with Leukemia before and after the Treatment
Authors: Tamara Sorokina, Irina Shipounova, Alexey Bigildeev, Nina I. Drize, Larisa A. Kuzmina, Elena N. Parovichnikova, Valery G Savchenko
Journal: Blood (2016)
Long-Term Follow-up of Ongoing Patients in 2 Studies of Omacetaxine Mepesuccinate for Chronic Myeloid Leukemia.
Authors: Hagop M. Kantarjian, Jeffrey H. Lipton, Michele Baccarani, Franck E. Nicolini, Meir Wetzler, Luke Akard, Laurence Legros, Krzysztof Warzocha, Adam Craig, Jorge E. Cortes
Journal: Blood (2012)
Enrichment of Mononuclear Cells From Cryopreserved Cord Blood Units Using the Purecell” Select System.
Authors: Bryan P Spencer, Indreshpal Kaur, Patrick Fong, Safa Karandish, Nirmali Ponweera, Omar Baez, Elizabeth J Shpall, Richard E Champlin, John D McMannis
Journal: Blood (2009)