tbuckley/cabot-search huggingface dataset:
Abstract 12698: Long term Outcomes and Cardiac Surgery in Critically Ill Patients With Infective Endocarditis
Authors: Mariana Mirabel, Romain Sonneville, David Hajage, Emmanuel Novy, Florence Tubach, Michel Wolff, Jean-Louis Trouillet
Journal: Circulation (2013)

Introduction: The aims are to assess long-term outcomes and management of patients admitted to ICU with left-sided IE, and to evaluate the impact of surgery. Methods and Results: Among the 198 pati...
Small Dense Low‐Density Lipoprotein Cholesterol Predicts Cardiovascular Events in Liver Transplant Recipients
Authors: Mohammad Bilal Siddiqui, Tamoore Arshad, Samarth Patel, Emily Lee, Somaya Albhaisi, Arun J. Sanyal, R. Todd Stravitz, Carolyn Driscoll, Richard K. Sterling, Trevor Reichman, Chandra Bhati, Mohammad Shadab Siddiqui
Journal: Hepatology (2019)

Cardiovascular disease (CVD) is an important cause of morbidity and mortality after liver transplantation (LT). Although LT is associated with dyslipidemia, particularly atherogenic lipoprotein subparticles, the impact of these subparticles on CVD-related events is unknown. Therefore, the aim of the current study was to evaluate the impact of small dense (sdLDL-C) low-density lipoprotein (LDL) cholesterol (LDL-C) on CVD events. Prospectively enrolled patients (N = 130) had detailed lipid profile consisting of traditional lipid parameters and sdLDL-C and were followed for CVD events. The primary endpoint was a CVD composite consisting of myocardial infarction (MI), angina, need for coronary revascularization, and cardiac death. Mean age of the cohort was 58 ± 11 years, and the most common etiology of liver disease (LD) was hepatitis C virus (N = 48) and nonalcoholic steatohepatitis (N = 23). A total of 20 CVD events were noted after median follow-up of 45 months. The baseline traditional profile was similar in patients with and without CVD events. A serum LDL-C cutoff of 100 mg/dL was unable to identify individuals at risk of a CVD event (P = 0.86). In contrast, serum concentration of atherogenic sdLDL-C >25 mg/dL was predictive of CVD events with a hazard ratio of 6.376 (95% confidence interval, 2.65, 15.34; P < 0.001). This relationship was independent of diabetes, hypertension, sex, ethnicity, LD, obesity, and statin use. Conclusion: sdLDL-C independently predicted CVD events whereas LDL-C did not. Thus, sdLDL-C may provide a useful clinical tool in risk stratifying and managing patients after LT.
Phase I/II trial testing safety and immunogenicity of the multipeptide IMA950/poly-ICLC vaccine in newly diagnosed adult malignant astrocytoma patients
Authors: Denis Migliorini, Valérie Dutoit, Mathilde Allard, Nicole Grandjean Hallez, Eliana Marinari, Valérie Widmer, Géraldine Philippin, Francesca Corlazzoli, Robin Gustave, Mario Kreutzfeldt, Nathalie Blazek, Joëlle Wasem, Andreas Hottinger, Avinash Koka, Shahan Momjian, Alexander Lobrinus, Doron Merkler, Maria-Isabel Vargas, Paul R Walker, Anna Patrikidou, Pierre-Yves Dietrich
Journal: Neuro-Oncology (2019)

Peptide vaccines offer the opportunity to elicit glioma-specific T cells with tumor killing ability. Using antigens eluted from the surface of glioblastoma samples, we designed a phase I/II study to test safety and immunogenicity of the IMA950 multipeptide vaccine adjuvanted with poly-ICLC (polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethylcellulose) in human leukocyte antigen A2+ glioma patients.Adult patients with newly diagnosed glioblastoma (n = 16) and grade III astrocytoma (n = 3) were treated with radiochemotherapy followed by IMA950/poly-ICLC vaccination. The first 6 patients received IMA950 (9 major histocompatibility complex [MHC] class I and 2 MHC class II peptides) intradermally and poly-ICLC intramuscularly (i.m.). After protocol amendment, IMA950 and poly-ICLC were mixed and injected subcutaneously (n = 7) or i.m. (n = 6). Primary endpoints were safety and immunogenicity. Secondary endpoints were overall survival, progression-free survival at 6 and 9 months, and vaccine-specific peripheral cluster of differentiation (CD)4 and CD8 T-cell responses.The IMA950/poly-ICLC vaccine was safe and well tolerated. Four patients presented cerebral edema with rapid recovery. For the first 6 patients, vaccine-induced CD8 T-cell responses were restricted to a single peptide and CD4 responses were absent. After optimization of vaccine formulation, we observed multipeptide CD8 and sustained T helper 1 CD4 T-cell responses. For the entire cohort, CD8 T-cell responses to a single or multiple peptides were observed in 63.2% and 36.8% of patients, respectively. Median overall survival was 19 months for glioblastoma patients.We provide, in a clinical trial, using cell surface-presented antigens, insights into optimization of vaccines generating effector T cells for glioma patients.Clinicaltrials.gov NCT01920191.
Abstract 17550: Smoking Cessation in Young Adults Following Myocardial Infarction is Associated With Better Prognosis
Authors: David Biery, Avinainder Singh, Bradley Collins, Julio M Baez, Mary Cawley, Roxanna Rajabi, Monica Eng, Marcelo F Di Carli, Khurram Nasir, Deepak L Bhatt, Ron Blankstein
Journal: Circulation (2017)

Introduction: Smoking rates are declining, but remain high in young adults. We investigated the prevalence of smoking and the benefits of cessation in young individuals under the age of 50 who expe...
Defining Minimal Clinically Important Differences (MCID) in Chronic Cough: Analyses of Objective Cough Counts from a Phase 2 Randomized Controlled Trial
Authors: Allison M. Nguyen, David Muccino, Surinder Birring, Elizabeth D. Bacci, Margaret K. Vernon, Daniel Mines, Jaclyn A. Smith
Journal: Journal of Allergy and Clinical Immunology (2019)
Targeted Therapy for AML Expressing RUNX1 Mutation
Authors: Christopher Peter Mill, Warren Fiskus, Courtney D. DiNardo, Yimin Qian, Kanak Raina, Koichi Takahashi, Tapan Kadia, Dyana T. Saenz, Agnieszka J Nowak, Baohua Sun, Craig M Crews, Kapil N. Bhalla
Journal: Blood (2017)
A man with a painful and swollen left testicle
Authors: William Maynard, Sarah Reid
Journal: BMJ (2019)

A 34 year old man was referred to the emergency department by his general practitioner with a 3 day history of painful swelling of his left testicle and lethargy. He had first noticed the swelling five weeks earlier. He had also noticed an intermittent dull ache over that time but he had not sought medical attention. The patient had no urinary symptoms, history of fevers, vomiting, or weight loss. He had no clinically significant medical or family history, worked as a civil engineer, and was a non-smoker. Observations were within the expected range for all parameters except for pyrexia of 38.2°C. Examination showed an enlarged firm left testicle of approximately 5 × 4 × 4 cm with an irregular superior pole and a thickened tender spermatic cord. Examination of the right testicle and abdomen was normal.

View this table:

Blood test results



Scrotal doppler ultrasound showed a mixed echogenic lesion measuring 4.5 × 3.4 × 3.4 cm containing a cystic component measuring approximately 2 cm and marked hyperaemia in the left testicle. Mid stream and first pass urine samples were sent for urinary and genitourinary bacteriology and the patient was admitted to the urology ward. …
Nrf2 signaling and inflammation are key events in physical plasma-spurred wound healing
Authors: Anke Schmidt, Thomas von Woedtke, Brigitte Vollmar, Sybille Hasse, Sander Bekeschus
Journal: Theranostics (2019)

Wound healing is strongly associated with the presence of a balanced content of reactive species in which oxygen-dependent, redox-sensitive signaling represents an essential step in the healing cascade. Numerous studies have demonstrated that cold physical plasma supports wound healing due to its ability to deliver a beneficial mixture of reactive species directly to the cells. Methods: We described a preclinical proof-of-principle-concept of cold plasma use in a dermal, full-thickness wound model in immunocompetent SKH1 mice. Quantitative PCR, Western blot analysis, immunohistochemistry and immunofluorescence were perfomed to evaluate the expression and cellular translocation of essential targets of Nrf2 and p53 signaling as well as immunomodulatory and angiogenetic factors. Apoptosis and proliferation were detected using TUNEL assay and Ki67 staining, respectively. Cytokine levels in serum were measured using bead-based multiplex cytokine analysis. Epidermal keratinocytes and dermal fibroblasts were isolated from mouse skin to perform functional knockdown experiments. Intravital fluorescence analysis was used to illustrate and quantified microvascular features. Results: Plasma exerted significant effects on wound healing in mice, including the promotion of granulation and reepithelialization as a consequence of the migration of skin cells, the balance of antioxidant and inflammatory response, and the early induction of macrophage and neutrophil recruitment to the wound sites. Moreover, through an early and local plasma-induced p53 inhibition with a concomitant stimulation of proliferation, the upregulation of angiogenetic factors, and an increased outgrowth of new vessels, our findings explain why dermal skin repair is accelerated. The cellular redox homeostasis was maintained and cells were defended from damage by a strong modulation of the nuclear E2-related factor (Nrf2) pathway and redox-sensitive p53 signaling. Conclusions: Although acute wound healing is non-problematic, the pathways highlighted that mainly the activation of Nrf2 signaling is a promising strategy for the clinical use of cold plasma in chronic wound healing.
Assessment of Price Changes of Existing Tumor Necrosis Factor Inhibitors After the Market Entry of Competitors
Authors: Alvaro San-Juan-Rodriguez, Max V. Prokopovich, William H. Shrank, Chester B. Good, Inmaculada Hernandez
Journal: JAMA Internal Medicine (2019)

This study uses wholesale medication acquisition costs and Medicare claims data to assess how prices of existing tumor necrosis factor inhibitors changed in response to the market entry of new tumor necrosis factor inhibitors.
Velocities of Naturally Occurring Myocardial Shear Waves Increase With Age and in Cardiac Amyloidosis
Authors: Aniela Petrescu, Pedro Santos, Marta Orlowska, João Pedrosa, Stéphanie Bézy, Bidisha Chakraborty, Marta Cvijic, Monica Dobrovie, Michel Delforge, Jan D'hooge, Jens-Uwe Voigt
Journal: JACC. Cardiovascular imaging (2019)
No Association of Discontinuing Tumor Necrosis Factor Inhibitors Before Gestational Week Twenty in Well‐Controlled Rheumatoid Arthritis and Juvenile Idiopathic Arthritis With a Disease Worsening in Late Pregnancy
Authors: Frauke Förger, Gretchen Bandoli, Yunjun Luo, Loan Robinson, Diana L. Johnson, Christina D. Chambers
Journal: Arthritis & Rheumatology (2019)

Objective To investigate whether the discontinuation of tumor necrosis factor inhibitors ( TNF i) during pregnancy is associated with any changes of the disease course in women with rheumatoid arthritis ( RA ) and juvenile idiopathic arthritis ( JIA ). Methods Pregnant women with RA and JIA from the US and Canada were enrolled in the Organization of Teratology Information Specialists ( OTIS ) Autoimmune Diseases in Pregnancy Project, a prospective cohort study. Information about medication and disease activity (patient‐reported outcome measures) was collected prior to gestational week 20 and at gestational week 32. Associations between patterns of TNF i continuation or discontinuation and disease activity changes were tested in unadjusted and multivariate analyses. Results Among 490 women (397 with RA , 93 with JIA ) enrolled between 2005 and 2017, 122 (24.9%) discontinued a TNF i before gestational week 20, 201 (41.0%) received a TNF i beyond week 20, and 167 (34.1%) did not receive a TNF i during pregnancy. At the time of enrollment, disease activity was low to minimal in 72.9% of women. TNF i discontinuation was not associated with a clinically important worsening of patient reported outcome measures at the third trimester. Univariate but not multivariate analysis showed that women receiving TNF i beyond week 20 were more likely to experience improved disease activity scores at the third trimester. Conclusion Discontinuing TNF i before gestational week 20 seems feasible in women with RA and JIA who enter pregnancy with well‐controlled disease.
miR-577 Regulates TGF-β Induced Cancer Progression through a SDPR-Modulated Positive-Feedback Loop with ERK-NF-κB in Gastric Cancer
Authors: Yuhao Luo, Jianhua Wu, Qianying Wu, Xiaoyin Li, Jiani Wu, Jingwen Zhang, Xiaoxiang Rong, Jingjun Rao, Yulin Liao, Jianping Bin, Na Huang, Wangjun Liao
Journal: Molecular Therapy (2019)

Transforming growth factor β (TGF-β) drives epithelial-mesenchymal transition (EMT), playing vital roles in cancer metastasis. The crosstalk between microRNAs (miRNAs) and TGF-β are frequently observed and involved in TGF-β-induced EMT. Here, we determine that miR-577 is significantly upregulated in gastric cancer (GC). miR-577 expression is positively correlated with GC metastasis status and poor patient prognosis. Functional assays demonstrate that miR-577 promotes metastasis and chemoresistance by inducing EMT and stemness-like properties. Moreover, TGF-β promotes the expression of miR-577, and miR-577 participates TGF-β-mediated cancer metastasis. Mechanistically, TGF-β activates miR-577 via NF-κB-mediated transcription, and miR-577 enhances TGF-β signaling by targeting the serum deprivation protein response (SDPR), which directly interacts with ERK to inactivate the ERK-NF-κB pathway, hence forming a feedback loop to drive tumor metastasis. A plausible mechanism of EMT induction by the TGF-β network is elucidated. Our findings suggest that the TGF-β-miR-577-SDPR axis may be a potential prognostic marker and therapeutic target against cancer metastasis in GC.
Cleavage of Anti-PF4/H IgG Antibodies By Ides, and Potential Benefit in the Treatment of Heparin-Induced Thrombocytopenia
Authors: Claire Kizlik-Masson, Quentin Deveuve, Yuhang Zhou, Caroline Vayne, Gilles Thibault, Steven Edward McKenzie, Claire Pouplard, Stéphane Loyau, Jérôme Rollin, Yves Gruel
Journal: Blood (2018)
Small-Molecule Inhibition of PRMT5 Induces Translational Stress and p53 in JAK2V617F Mutant Myeloproliferative Neoplasms
Authors: Stefan Sonderegger, Loretta Cerruti, Cedric Tremblay, Emma Toulmin, Jesslyn Saw, Tom Nebl, Katherine M Hannan, Steven W. Lane, Hendrik Falk, Ashwin Unnikrishnan, Paul Stupple, Ian Street, Stephen Jane, Rachel Altura, Benjamin Nicholson, David J. Curtis
Journal: Blood (2018)
Abstract 17676: Microrna-33b Promotes Atherosclerotic Plaque Formation in Apoe-/- Mice
Authors: Tomohiro Nishino, Takahiro Horie, Yasuhide Kuwabara, Tetsushi Nakao, Masataka Nishiga, Yuya Ide, Fumiko Nakazeki, Satoshi Koyama, Masahiro Kimura, Takeshi Kimura, Koh Ono
Journal: Circulation (2017)

Introduction: MicroRNA-33a and b (miR-33a/b) play an important role in regulating HDL-C synthesis and reverse cholesterol transport through post-transcriptional repression of cholesterol efflux genes (e.g. ABCA1). Recently several groups including ours have showed that miR-33a could be a potential target for treatment of atherosclerosis using mouse models. Although in human miR-33a/b are transcribed from an intron of SREBF2/1 with their host genes respectively, a part of miR-33b is lacking from Srebf1 intron in rodents. Thus the precise role of miR-33b on atherosclerosis in vivo remains uncertain. Methods and Results: We have developed miR-33b knock-in (miR-33b+/+) mice and have crossed them with Apoe-/- mice. MiR-33b+/+Apoe-/- mice showed a decrease in serum HDL-C levels with reduced cholesterol efflux capacity compared with miR-33b-/-Apoe-/- mice after being fed with western diet for 12 weeks. Unexpectedly we also found serum cholesterol peak shift from large VLDL-C to small LDL-C and decreased TG level...
Abstract 16698: Rapid Evaluation of Acute Myocardial Infarction Using a Change in High-Sensitivity Cardiac Troponin T Over 1 Hour
Authors: Chaun M Gandolfo, James McCord, Michael P Hudson, Michele Moyer, Robert Christenson, Bernard Cook, Gordon Jacobsen, Richard Nowak
Journal: Circulation (2017)

Introduction: A 0/1 hour rule-in/rule-out acute myocardial infarction (AMI) algorithm using a change in high sensitivity cardiac troponin T (hs-cTnT) has been reported in non-United States (US) studies, but has not been well-studied in the US. The algorithm is supported by the 2015 European Society of Cardiology (ESC) guidelines. Additionally, how the algorithm performs in regards to type 1 and type 2 AMI has not been described. Hypothesis: The purpose of this study was to apply the established algorithm to patients presenting to a US Emergency Department with suspected AMI to determine its clinical usefulness. Methods: Patients with symptoms suspicious of AMI that led the clinician to order serial cardiac markers at a single US urban center were enrolled. Patients with ECG findings that led to immediate reperfusion therapy were excluded. Baseline and 60-minute blood samples were obtained for hs-cTnT (Roche Diagnostics). AMI diagnosis was independently adjudicated by 2 physicians after review of all tests...
Pembrolizumab plus trastuzumab in trastuzumab-resistant, advanced, HER2-positive breast cancer (PANACEA): a single-arm, multicentre, phase 1b–2 trial
Authors: Sherene Loi, Anita Giobbie-Hurder, Andrea Gombos, Thomas Bachelot, Rina Hui, Giuseppe Curigliano, Mario Campone, Laura Biganzoli, Hervé Bonnefoi, Guy Jerusalem, Rupert Bartsch, Manuela Rabaglio-Poretti, Roswitha Kammler, Rudolf Maibach, Mark J Smyth, Angelo Di Leo, Marco Colleoni, Giuseppe Viale, Meredith M Regan, Fabrice André, Debora Fumagalli, Richard D Gelber, Theodora Goulioti, Anita Hiltbrunner, Rita Hui, Heidi Roschitzki, Barbara Ruepp, Fran Boyle, Rolf Stahel, Stefan Aebi, Alan S Coates, Aron Goldhirsch, Per Karlsson, Ingrid Kössler, Stamatina Fournarakou, Adriana Gasca, Rita Pfister, Sabrina Ribeli-Hofmann, Magdelena Weber, Daniela Celotto, Carmen Comune, Michela Frapolli, Magdalena Sánchez-Hohl, Hui Huang, Caitlin Mahoney, Karen Price, Karolyn Scott, Holly Shaw, Susan Fischer, Monica Greco, Colleen King, Stefania Andrighetto, Martine Piccart-Gebhart, Heather Findlay, Michelle Jenkins, Vassiliki Karantza, Jaime Mejia, Patrick Schneier
Journal: The Lancet Oncology (2019)
Who Is the Best Donor for the Second Transplant?: HLA Discrepancy between Graft and Host Rather Than That Graft and First Donor May Impact the Second Transplant Outcome from the JSHCT
Authors: Yoshinobu Maeda, Tomotaka Ugai, Eisei Kondo, Kazuhiro Ikegame, Makoto Murata, Naoyuki Uchida, Toshihiro Miyamoto, Satoshi Takahashi, Kazuteru Ohashi, Hirohisa Nakamae, Makoto Hirokawa, Tatsuo Ichinohe, Yoshiko Atsuta, Yoshinobu Kanda, Junya Kanda
Journal: Blood (2018)
Patient and disease characteristics of colorectal cancer in a cohort of young patients.
Authors: Wissam Hanayneh, Thomas J. George, Thomas Read, Sanda Tan, Atif Iqbal, Carmen Joseph Allegra, Hiral D. Parekh
Journal: Journal of Clinical Oncology (2019)

513 Background: Despite effective screening for colorectal cancer (CRC), the incidence has been steadily rising in younger patients; the etiology for this phenomenon remains elusive. Methods: CRC patients diagnosed at &lt; 50 years of age (UF institutional registry 2000-2017) constituted the IRB approved study cohort. Results: Young CRC patients (n = 286) comprised 16% of total CRC patients (n = 1806) treated at our institution. (See table for demographics and tumor characteristics.) The median age at diagnosis was 45 years (range 17-50) with two-thirds diagnosed at age 40-50 (n-212, 74%) and 182 patients (63.6%) had a history of tobacco and/or alcohol use. The majority of patients (73.1%) had a left-sided tumor and 35% (n = 99) had stage 4 disease at presentation. The median time to diagnosis from onset of first symptoms was 90 days. DNA mismatch repair gene deficiencies (dMMR) and/or microsatellite instability (MSI) was tested in 172 patients (60.1%); 18 (10.5%) had MSI-H or dMMR tumors and 11 of those had confirmed Lynch syndrome through. Next generation sequencing (NGS, n = 71) or mutational analysis (n =79) was performed on 52.4%; most common mutation was KRAS (40.7%, n = 61) followed by TP53 (7.33%; n = 11) and PIK3CA (5.33%; n = 8). BRAF V600E was seen in five patients and another two had BRAF variant. Conclusions: Our results reveal that the majority of younger CRC were 40-50 years age group with a female preponderance. Advanced disease at diagnosis and longer median time to diagnosis should prompt educational efforts regarding appropriate screening and timely diagnostic investigation in this patient cohort. [Table: see text]
A phase II/III randomized study to compare the efficacy and safety of rigosertib plus gemcitabine versus gemcitabine alone in patients with previously untreated metastatic pancreatic cancer
Authors: B.H. O'Neil, A.J. Scott, W.W. Ma, S.J. Cohen, D.L. Aisner, A.R. Menter, M.A. Tejani, J.K. Cho, J. Granfortuna, A.L. Coveler, O.O. Olowokure, J.C. Baranda, M. Cusnir, P. Phillip, J. Boles, R. Nazemzadeh, M. Rarick, D.J. Cohen, J. Radford, L. Fehrenbacher, R. Bajaj, V. Bathini, P. Fanta, J. Berlin, A.J. McRee, R. Maguire, F. Wilhelm, M. Maniar, A. Jimeno, C.L. Gomes, W.A. Messersmith
Journal: Annals of Oncology (2016)
Proliferation control of specific-effector T cells and T-Regulatory cells by Tim-3 and Galectin-9 in Drug-Induced Maculopapular Exanthema
Authors: Tahia D. Fernandez, Maria Francisca Palomares, Ruben Fernandez-Santamaria, Alba Rodriguez-Nogales, Maria Jose Rodriguez, Ana Molina Bueno, María Isabel Montañez, Jose Julio Laguna, M.J. Torres, Cristobalina Mayorga
Journal: Journal of Allergy and Clinical Immunology (2019)
Environmental risks and non-communicable diseases
Authors: Annette Prüss-Ustün, Emilie van Deventer, Pierpaolo Mudu, Diarmid Campbell-Lendrum, Carolyn Vickers, Ivan Ivanov, Francesco Forastiere, Sophie Gumy, Carlos Dora, Heather Adair-Rohani, Maria Neira
Journal: BMJ (2019)

Annette Pruss-Ustun and colleagues consider the role of air pollution and other environmental risks in non-communicable diseases and actions to reduce them
Abstract 12188: Utilization Rates of Primary Prevention Implantable Cardioverter-Defibrillators: A 2012 Calculation for a Midwestern Health Referral Region
Authors: Allen Hoang, Changyu Shen, James Zheng, Stanley Taylor, Marc Rosenman, Alfred Buxton, Peng-Sheng Chen
Journal: Circulation (2013)

Background: Database studies suggest that utilization rates (UR) of implantable cardioverter-defibrillators (ICD) for primary prevention of sudden cardiac death (PPSCD) are highly variable, with racial and gender discrepancies previously observed. However, because rates vary by referral regions and few studies have utilized comprehensive review of source documents (charts), the ICD UR in the community remains unclear. We sought to establish the ICD UR in central Indiana. Methods and Results: We queried electronic medical records for patients with left ventricular ejection fraction (LVEF) ≤ 0.35 between June 2011 and May 2012, which returned 1863 unique patients. The ICD UR is defined by x/(x+y), where x=PPSCD ICD’s utilized and y=patients with Class I indication but without ICD implantation during the same time period. We found 1672 without (Cohort A) and 191 with (Cohort B) procedure code 37.94 (Implantation or replacement of ICD). To identify those patients eligible for ICD, we manually reviewed a strat...
Multi-Omics of Aurora Inhibition Induced Polyploidy Reveals Mechanisms of Disease Relapse in MYC/BCL2-Addicted High Grade B-Cell Lymphoma
Authors: Shariful Islam, Andrew Paek, Michael Hammer, Savithri Rangarajan, Robert Ruijtenbeek, Laurence Cooke, Eric Weterings, Daruka Mahadevan
Journal: Blood (2018)
Sequential Brentuximab Vedotin (Bv) before and after Adriamycin, Vinblastine, and Dacarbazine (Bv-AVD) for Older Patients with Untreated Classical Hodgkin Lymphoma (cHL): Final Results from a Multicenter Phase II Study
Authors: Andrew M Evens, Ranjana H. Advani, Michelle A. Fanale, Sonali M. Smith, Irene Helenowski, Borko Jovanovic, R. Gregory Bociek, Andreas Klein, Jane N. Winter, Leo I. Gordon, Paul A. Hamlin
Journal: Blood (2017)