tbuckley/cabot-search huggingface dataset:
SAT0411 Investigations for the diagnosis of septic arthritis in the acute setting. results from a single tertiary centre over 5 years
Authors: P. Shamdasani, D. Liew, C. McMaster, A. Foote, A. Hardidge, R. Buchanan
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Septic arthritis is a rheumatologic emergency associated with significant morbidity and mortality<sup>1</sup>. Timely and accurate diagnosis in the emergency department is essential for early medical and surgical involvement. <h3>Objectives</h3> To examine the predictive value of investigations used to diagnose septic arthritis in the acute setting. <h3>Methods</h3> A retrospective chart review was conducted on all patients referred from the emergency department to the orthopaedic surgery service with a potential diagnosis of septic arthritis between <sup>June 2010</sup> and December 2015 at the Austin Hospital in Melbourne, Australia. Data was collected regarding demographic details, risk factors, pathology results, antibiotic prescribing, joint aspirate and theatre samples. <h3>Results</h3> The study included 126 patients with 132 emergency department presentations involving 141 joints. The median age of patients was 70 (IQR 52.3–79.8); 86 (68.3%) were male. The most common joints involved were the knee (49.6%) and hip (17.7%). In 88 of the 132 presentations (67%), culture of the synovial fluid was positive. 19 of these 88 (22%) culture positive presentations had no classical risk factors for septic arthritis (joint prosthesis, previous septic arthritis, immunosuppressed, previous joint disease, intravenous drug use). 12 of the 88 (13%) culture positive patients had symptoms for longer than 4 weeks on presentation in contrast to 2 of the 44 (5%) in culture negative group. There were 8 presentations with multiple joints involved. None of these presentations were in the culture positive group. There was no evidence of a relationship between WCC and culture status (p=0.56) or CRP and culture status (p=0.64), either singly or when combined. There were 94 joint aspirations performed in 132 presentations. 30 (32%) joint aspirations required ultrasound guidance. 42 (45%) joint aspirations had antibiotics administered prior to sample collection. In the culture positive presentations 25 (28.4%) did not have a joint aspirate performed prior to surgical washout. Crystals were seen in 19 (30.2%) culture positive patients. 26 (29.5%) culture positive presentations had no growth on aspirate culture but had positive theatre cultures. <h3>Conclusions</h3> While septic arthritis is a common emergency presentation, there are few useful non-invasive diagnostic tests. Although risk factors aid in stratifying risk, duration of symptoms and inflammatory markers are poor differentiators. Neither the presence of crystals nor the absence of growth on aspirate culture exclude septic arthritis. <h3>Reference</h3> [1] Gupta M, Sturrock R, Field M. A prospective 2-year study of 75 patients with adult-onset septic arthritis. Rheumatology2001(40):24–30. <h3>Disclosure of Interest</h3> None declared
Racial Disparities in the Utilization of Recommended Supportive Care Among Patients with Multiple Myeloma in the United States
Authors: Smith Giri, Weiwei Zhu, Rong Wang, Amer M. Zeidan, Nikolai A. Podoltsev, Steven D. Gore, Xiaomei Ma, Amy J. Davidoff, Scott F Huntington
Journal: Blood (2018)
AB0977 Correlation of the level of c-reactive protein and bone mineral density in patients with gonarthritis
Authors: T. Tarasenko
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> The results of recent studies also indicate a link between loss of bone mineral density (BMD) and progressive loss of articular cartilage in patients with knee joint osteoarthritis (OA). The presence of correlation of changes in bone tissue and degradation of cartilage in OA is due to the possible presence of common pathogenesis chains, including activation of proinflammatory mediators. <h3>Objectives</h3> Determine the relationship between the level of C-reactive protein (CRP) and the level of BMD in patients with gonarthritis. <h3>Methods</h3> We conducted a cross sectional study including confirmed radiographic knee osteoarthritis according to Kellgren-Lawrence scale, with normal and reduced BMD according to the classification of Report of a WHO Study Group. The structural and functional status of bone tissue in patients was evaluated using the method of ultrasonic densitometry and DEXA at the beginning of treatment and 12 months. The CRP level was determined at the beginning of the observation and after 1, 3, 6, 9 and 12 months. The two groups were compared on the level of BMD, radiological grade, the level of CRP and WOMAC function after adjusting for significant covariates. Multiple regression analysis was used to identify the independent effects to each specific component for level of CRP on knee osteoarthritis parameters. <h3>Results</h3> One hundred forty women were included. The mean age was 55.28±0.80<sup>37–75</sup> years. Overweight had 86.42% of patients. The body mass index averaged 30.18±0.43<sup>23–37</sup> kg/m2. According to Kellgren-Lawrence classification, 55% of patients had II and 45% of patients – III radiological stage of gonarthritis. 55.7% of knee OA patients had reduced bone mineral density. Multiple regression analysis showed, after adjusting for significant covariates, that the CRP level was significantly higher (p&lt;0.0001) in patients with reduced BMD compared to normal (6.32±1.67 mg/L and 4.74±0.75 mg/L respectively), an average of 33, 3%. <h3>Conclusions</h3> It was found that in patients with gonarthritis with reduced BMD, a higher level of CRP was observed at 33.3%, which was associated with a more severe course of the disease. <h3>Reference</h3> [1] It is recommended to study the severity of the progression and progression of OA to study the level of CRP and mineral density of bone tissue. <h3>Disclosure of Interest</h3> None declared
AB0255 Does menopause affect disease activity of rheumatoid arthritis(RA)? an analysis from the ninja cohort in 2016
Authors: K. Nagahata, S. Tsuzuki, S. Hattori, K. Yomono, S. Suzuki, S. Takenouchi, R. Yokochi, N. Hagino, T. Matsui, S. Tohma
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Early menopause may be a risk of developing RA<sup>1</sup>. Although there are many reports about menopause and the onset of RA, it is not yet clear how the disease activity of RA differs for each generation including menopause. <h3>Objectives</h3> To clarify how disease activity differs for each generation, especially in menopausal period. <h3>Methods</h3> Using the Japanese large RA cohort database (NinJa:National database of Rheumatic Diseases in Japan) of 2016, we divided 12257 RA females into three groups of age (under 44 years old=1, 45 to 55 years old=2, defined as a menopausal group, over 56 years old=3) and analysed them cross-sectionally. We conducted a one-way ANOVA on disease activity indexes such as Tender joint count (TJC), Swollen joint count (SJC), DAS28, HAQ-DI. <h3>Results</h3> Table 1 shows the number of people per group, the duration of disease, the titer of RF/ACPA, and the proportion of drugs used. The average usage of prednisone and the use of biologics was the most common in group 1. In table 2, TJC was the largest in group 2 (p&lt;0.01). Furthermore, the difference between groups seen in TJC tends to be larger than TJC 28. There was no significant difference in SJC (SJC28) between three groups. Other disease activity indicators (ESR, CRP, DAS 28, HAQ-DI) were the largest in group 3 (p&lt;0.01) and the percentage of Boolean remission was also lowest in group 3 (p=0.02). <h3>Conclusions</h3> This study shows that TJC may increase during menopause, unlike other disease activity indicators. Especially in group 2, it is possible that the joints which can't be evaluated at TJC 28 are affecting the results because in TJC, compared with TJC 28, there is a larger group difference. Although further studies are needed, an increase in TJC may reflect menopausal joint symptoms. <h3>Reference</h3> [1] Pikwer M, et al. Ann Rheum Dis. 2012Mar;71(3):378–81. <h3>Disclosure of Interest</h3> None declared
Abstract 19041: Institution of Localized High Frequency Electrical Stimulation Targeting Early Myocardial Infarction: Effects on Left Ventricular Function and Geometry
Authors: Michael C Genau, Paige E Perreault, Eva Romito, Heather Doviak, Christina B Logdon, Stephen Ruble, Shayne Barlow, Francis G Spinale
Journal: Circulation (2016)

Background: Therapeutic strategies that are focused upon transforming an existing myocardial infarction (MI) and thereby altering the course of post-MI remodeling process have not been forthcoming....
AB0729 Quality of life assessment in systemic sclerosispatients treated with autologous stem cell transplantation: a longitudinal study
Authors: A.L.C. Guimaraes, K. Costa-Pereira, J.B. Elias, D.A. Moraes, E.A. Oliveira-Cardoso, J.T. Garcia, M.C. Oliveira, V. Leopoldo, A.F. Zombrilli, T.M. Costa, M. Vasconcelos, M.C. Oliveira
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Autologous Hematopoietic Stem Cell Transplantation (AHSCT) has been explored as a therapeutic option for patients with systemic sclerosis (SSc) that do not respond to conventional treatment. <h3>Objectives</h3> To investigate changes in quality of life of severe and rapidly progressive SSc patients treated with AHSCT. <h3>Methods</h3> This is a longitudinal and comparative study. Patients were evaluated before (n=27), and at 6 (n=27) and 12 months (n=21) after AHSCT. The Generic Questionnaire for Evaluation of Quality of Life Medical Outcomes Study 36 Item Short-Form Health Survey (SF-36) was applied individually, face-to-face, under patient written consent. This questionnaire evaluates eight domains: physical functioning (PF), role-physical (RP), bodily pain (BP), general health (GH), social functioning (SF), vitality (VT), role-emotional (RE) and mental health (MH). Results were transformed into a 0–100 scale, where zero corresponds to a worse health condition and 100 to the best possible score, and submitted to statistical analysis. Significance was defined as p&lt;0.05. <h3>Results</h3> Most participants were females (n=24), with mean age of 33 years (standard deviation, SD=10.33) and mean time from diagnosis of 34.4 months (SD=34.89). Before AHSCT, the mostly impaired aspects were: PF (mean=8.33, SD=18.34), and RP (mean=38.52, SD=21.56), while MH (mean=61.63, SD=15.46) and SF (mean=56.87, SD=27.17) were mostly preserved. At 6 and 12 months post-AHSCT, there was significant improvement of the SF-36 scores in the following domains: PF (6 months, p&lt;0.01, 12 months, p&lt;0.01); RP (6 months, p&lt;0.01, 12 months, p&lt;0.01); BP (6 months, p&lt;0.01, 12 months, p&lt;0.01); GH (6 months, p&lt;0.01, 12 months, p=0.02); VT (6 months, p&lt;0.01, 12 months, p&lt;0.01); MH (6 months, p&lt;0.01, 12 months, p&lt;0.01). The SF domain showed significant increase only at 12 months (p=0.02). The only domain in which there was no significant change was RE. <h3>Conclusions</h3> Increases in the physical components of quality of life are more evident in the initial periods that follow AHSCT, while improvements in mental state, which are also associated with social aspects, are detected on longer follow-up. These data reinforce the relevance of AHSCT upon patient quality of life, signalling the importance of psychotherapeutic evaluations and follow-up. <h3>Disclosure of Interest</h3> None declared
SP0005 Inflammation and cancer: friend or foe
Authors: C.S. Roxburgh
Journal: Annals of the Rheumatic Diseases (2018)

<h3></h3> Cancer associated inflammation and the host immune response are key determinants of progression and outcome in solid malignancies. There is now persuasive evidence that inflammation is key to tumourigenesis via dna damage, stimulation of angiogenesis and proliferation, and inhibition of apoptosis. there have long been suspicions that dysregulated immune and inflammatory responses promote the progression and dissemination of established cancers and there is a heightened risk of cancer development in individuals with chronic inflammatory diseases. the tumour microenvironment is now viewed as a battleground for pro-tumour and anti-tumour responses. We now see an increase array of novel therapeutic targets targeting innate and adaptive components of the immune response to cancer. ONCO-Immunology with immunotherapy are an established part of clinical practice differing from conventional anti-cancer treatments in that the strategies do not principally target cancer cells. This talk will focus on the evidence that inflammation influences malignant progression in gi malignancy discussing novel therapeutic strategies. <h3>Disclosure of Interest</h3> None declared
FRI0713-HPR The patients’ perspectives towards the provision of information during transition to a biosimilar
Authors: J. Kreuk, A. Twisk, J. Meilink, R. Alblas, W. van der Weele, R.C. Hebing, J. Ruwaard, M. l'Ami, Z. Layegh, G. Wolbink
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> In July 2015, at the Amsterdam Rheumatology and Immunology Centre, location Reade, 93% of the patients with rheumatoid arthritis, treated with reference product infliximab switched to the biosimilar infliximab. This transition was needed to enable cost savings. Patients gained information via several ways, where the rheumatology nurses had a central role in informing the patients. Patients' perspectives are warranted to investigate the effect of the transition to the biosimilar. <h3>Objectives</h3> To investigate patients' perspectives towards the provided information regarding the switch to the biosimilar. <h3>Methods</h3> Consecutive patients treated with reference product infliximab were switched to the biosimilar in the period July 2015 to June 2016 at the Amsterdam Rheumatology and immunology Center, Reade. Patients were informed by a letter about the transition to the biosimilar and were subsequently contacted by a nurse or the pharmacist for additional questions and whether they agreed upon the switch. All patients who were switched from the reference product to the biosimilar were approached at the day care to fill in a questionnaire. In this qualitative questionnaire, patients were asked to evaluate the information provision process and how they gained information about the transition to the biosimilar initially. This was done by the nurses of the day care. <h3>Results</h3> All patients who switched to the biosimilar (n=46) filled in the questionnaire, of which 15 patients scored the information provision as excellent (33%), 25 patients as good (54%), 4 patients as reasonable (9%) and 2 patients found the information sufficient (4%). Furthermore, the majority of patients was initially informed by nurses and rheumatologist prior to the letter that was send to all patients. In total, 12 patients were initially informed by rheumatology nurse (26%), 12 patients by the rheumatologist (26%). Four patients were informed via the letter that was send at first (9%) and 3 patients gained the information about the transition otherwise (7%). Fifteen patients gave more than one answer to the question by whom they were informed initially. <h3>Conclusions</h3> Patients were satisfied about the information provision process, there were no patients who experienced the information provision insufficient. Next to the rheumatologist, rheumatology nurses played an important role in informing the patients about the transition. <h3>Disclosure of Interest</h3> J. Kreuk: None declared, A. Twisk: None declared, J. Meilink: None declared, R. Alblas : None declared, W. van der Weele: None declared, R. Hebing : None declared, J.Ruwaard: None declared, M. l9Ami: None declared, Z. Layegh: None declared, G.Wolbink Grant/research support from: Pfizer, Speakers bureau: Abbvie, UCB, BMS,Pfizer
DDRB must recommend above-inflation pay rise, says BMA
Authors: Abi Rimmer
Journal: BMJ (2019)

The BMA has said that its confidence in the independent body that advises the government on doctors’ pay has been eroded by pay rises below the rate of inflation.

Every year the Review Body on Doctors’ and Dentists’ Remuneration (DDRB) makes recommendations to the government on the salaries of doctors working in the NHS. In making those recommendations the …
The Future of Gene Editing — Toward Scientific and Social Consensus
Authors: Lisa Rosenbaum
Journal: New England Journal of Medicine (2019)

Interview with Dr. George Daley on the prospects for using genome editing to prevent genetic diseases. (10:11)Download The news that Chinese scientist He Jiankui had attempted to edit the CCR5 gene in the germline of two embryos led to a swift backlash in the scientific community. But the rogue experiment may inspire broader discussion about the fraught ethical issues involved.
Cooperation between SYK and ZAP70 Kinases As a Driver of Oncogenic BCR-Signaling in B-Cell Malignancies
Authors: Teresa Sadras, Jevon Cutler, Julia Aguade-Gorgorio, Zhengshan Chen, Kadriye Nehir Cosgun, Akhilesh Pandey, Markus Muschen
Journal: Blood (2018)
AB0360 Left atrial dilation is increased in patients with rheumatoid arthritis: a case-control study
Authors: D.A. Galarza-Delgado, J.R. Azpiri-López, I.J. Colunga-Pedraza, J.A. Dávila-Jiménez, E.E. Abundis-Márquez, A.H. Guillén-Lozoya, F.J. Torres-Quintanilla, R.E. Ramos-Cázares, R. Vera-Pineda, J.A. Cárdenas-de la Garza
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease, which mainly affects synovial joints.<sup>1</sup> Heart structural abnormalities are more prevalent in RA-patients than in general population, such as pericarditis, increased left ventricle mass and valvular disease.<sup>2</sup> Left atrial (LA) dilation predicts atrial fibrillation and congestive heart failure. It also increases the risk of developing thromboembolic events.<sup>3</sup> <h3>Objectives</h3> The aim of this study was to determine the prevalence of LA dilation in RA-patients and compare it with matched controls. <h3>Methods</h3> An observational, cross-section, case-control study was designed. Patients who fulfilled 1987 ACR and/or 2010 ACR/EULAR classification criteria for RA, 40–75 years old, with no overlap syndromes or atherosclerotic cardiovascular disease were included. The control group was matched by age, gender and comorbidities. A standard transthoracic echocardiogram was performed by a board-certified cardiologist. LA structure alterations were evaluated according to the American Society of Echocardiography guidelines. <h3>Results</h3> A total of 63 RA-patients and 41 control subjects were included. Demographic characteristics are shown in table 1. LA dilation, defined as a LA indexed volume (LAIV) &gt;34 mL/m<sup>2</sup>, was found in 9 (14.3%) patients of the RA-group, whereas no control subjects presented that condition (p=0.011). Mitral regurgitation was detected in 39 (62%) RA-patients and 7 (17%) control subjects (p&lt;0.001). <h3>Conclusions</h3> LA dilation is more prevalent in RA-patients when compared to matched controls. Prospective studies are needed to evaluate the influence of this condition in cardiovascular outcomes. <h3>References</h3> [1] You S, Cho CS, Lee I, Hood L, Hwang D, Kim WU. A systems approach to rheumatoid arthritis. PloS one2012;7(12):e51508. [2] Corrao S, et al. Heart involvement in rheumatoid arthritis: systematic review and meta-analysis. International Journal of Cardiology2013Sep 1;167(5):2031–8. [3] Foglieni C, et al. Early LA tissue features in patients with chronic mitral regurgitation and sinus rhythm: Alterations of not remodeled left atria. International Journal of Cardiology2016;219:433–438. <h3>Disclosure of Interest</h3> None declared
SAT0296 Patients with diffuse idiopathic skeletal hyperostosis and low back pain – evaluation and rehabilitation
Authors: R. Traistaru, D. Kamal, A.M. Bumbea, C. Kamal, O. Rogoveanu
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Diffuse Idiopathic Skeletal Hyperostosis (DISH) generally occurs in people between the ages of 50 and 60, more often in men than women. Physical therapy and kinetic program may help delay the loss of motion in affected joints and control the low back pain (LBP). In most cases of DISH with LBP, certain muscles of the back that stabilise the spine are reflexively inhibited and do not spontaneously recover even if patients are pain free with a return to normal activity levels. <h3>Objectives</h3> In our observational study we evaluated the role of rehabilitation program in quality of life and assessed the thickness of the erector spinae (ES) muscle in these patients and to evaluate the correlation between thickness difference in three different trunk postures and functional parameters. <h3>Methods</h3> 38 male patients (61.5 years mean age) with DISH and LBP were enrolled in this study. Frontal (AP) and lateral lumbosacral regions were radiological evaluated. Clinical and functional parameters were collected by a physiotherapist, that applied rehabilitation program (12 sessions of TENS, interferential current, ultrasound, aerobic training) and an US examination was performed by a physiatrist within 72 hours of the clinical examination. We performed ultrasonography to measure the thickness of the ES muscle at L4 and L5 level in maximum flexion, neutral posture, and maximum extension. All collected clinical and imagistic data were statistical analysed, pre-post rehabilitation. <h3>Results</h3> Multivariate analysis showed that thickness differences between flexed and neutral, and flexed and extended maximally positions were correlated statistically with functional parameters (VAS and The Roland-Morris Disability Questionnaire score). We obtained a significant improvement in VAS (p&lt;0,01) and Disability Questionnaire score (p&lt;0,05) after supervised rehabilitation program. <h3>Conclusions</h3> Although ossification in DISH generally affects the ligament of the spine, pain is more likely to arise in correlation with the erector vertebral muscle status. Visual observation of the image during contraction indicates that US may be a valuable biofeedback tool. Kinetic program (regular exercises that strengthen spine, walking and global stretching), avoiding sitting position for long periods of time, sleep on a correct mattress and optimal daily activities are the most important recommendations for all patients with DISH. <h3>Disclosure of Interest</h3> None declared
Abstract 11150: CXCR4 Overexpressing Mesenchymal Stem Cells (MSCCR4) Enhance Their Differentiation into Endothelial Cells via STAT3 Pathway
Authors: Jialiang Liang, Wei Huang, Yuhua Wang, Kai Kang, Zili Wen, Atif Ashraf, Ronald W Millard, Meifeng Xu, Muhammad Ashraf, Yigang Wang
Journal: Circulation (2012)

Background: Our previous studies indicated that MSCCR4 transplantation enhanced angiogenesis after myocardial infarction (MI). In this study we sought to identify the mechanism(s) by which this res...
Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers
Authors: Chao Liu, Junxiang Zhao, Fei Tian, Lili Cai, Wei Zhang, Qiang Feng, Jianqiao Chang, Fangning Wan, Yunjie Yang, Bo Dai, Yulong Cong, Baoquan Ding, Jiashu Sun, Weihong Tan
Journal: Nature Biomedical Engineering (2019)
Combined Infusion of CD19 and Bcma-Specific Chimeric Antigen Receptor T Cells for RRMM: Initial Safety and Efficacy Report from a Clinical Pilot Study
Authors: Lingzhi Yan, Jingjing Shang, Liqing Kang, Xiaolan Shi, Jin Zhou, Song Jin, Weiqin Yao, Ying Yao, Guanghua Chen, Ziling Zhu, Huirong Chang, Depei Wu, Lei Yu, Chengcheng Fu
Journal: Blood (2017)
Genomic and Immune Profiles of Multiple Myeloma Revealed By Whole Genome and Transcriptome Sequencing
Authors: Christopher J. Yoon, Hyojin Song, Seulki Song, Hyejoo Park, Dong-Yeop Shin, Junshik Hong, Inho Kim, Hyun Jung Lee, Byung-Su Kim, Jung Lim Lee, Sung-Soo Yoon, Young Seok Ju, Youngil Koh
Journal: Blood (2018)