tbuckley/cabot-search huggingface dataset:
Comparable 3-Year Disease-Free Survival Regardless of Anti-Thymocyte Globulin Inclusion in Pediatric Myeloablative Cord Blood Transplantation for Acute Lymphoblastic Leukemia
Authors: Doris M. Ponce, Rodney Sparapani, Junfang Chen, Vanderson Rocha, Daniel H. Fowler, Mary Eapen, Juliet N. Barker, Miguel-Angel Perales
Journal: Blood (2014)
Characterisation of the metabolomes of epigenetically distinct subgroups of paediatric ependymoma
Authors: Alison Woodward, Salah Abdelrazig, Catharine Ortori, David Barrett, Richard Grundy, Dong-Hyun Kim, Ruman Rahman
Journal: Neuro-Oncology (2019)

Abstract Paediatric ependymoma relapses in up to half of patients, with a five-year survival rate of only 25%. Comprehensive characterisation of the genetic/epigenetic mutation and transcriptome landscape has not yet translated to improved treatments. Metabolomics is a functional genomic approach, offering an opportunity to elucidate aberrant metabolic pathways and new therapeutic avenues. Metabolomics thus far has concentrated on 1H High-resolution Magic Angle Spinning, Magnetic Resonance Spectroscopy and Raman Spectroscopy, where low numbers of metabolites were identified compared to that feasible by Liquid Chromatography tandem Mass Spectrometry (LC-MS/MS). Here we present broader metabolome coverage using LC-MS/MS to separately analyse ependymoma polar and non-polar metabolites, comparing two subgroups from distinct neuro-anatomical compartments with different genetic and epigenetic drivers. We homogenised surgically resected ependymoma tissue from two epigenetic subgroups, posterior fossa A (n=10) and supratentorial RELA fusion (n=5), and extracted polar metabolites and lipids using methanol/water/chloroform 1:1:3. LC-MS/MS using a quadrupole-Orbitrap revealed 167 putative metabolites and 400 putative lipids significantly altered in relative abundance between the two subgroups. The metabolites predominantly mapped onto the taurine and hypotaurine pathway. Grade II and III PF-A tumours could be distinguished by the abundances of 53 metabolites, with three metabolites in the protein-lysine degradation pathway increased in abundance. The study presents a first-in-kind description of the paediatric ependymoma metabolome revealing PF-A and ST-RELA subgroups are metabolically distinct brain tumours and therefore warrant consideration of distinct anti-metabolite therapies. Paediatric ependymoma intra-tumour regions have been collected from 6 surgical resections and ongoing intra-tumour metabolomics/lipidomics integrated with transcriptomics will be discussed.
JAK2V617F and Loss of Ezh2 in Hematopoietic Cells Contribute Synergistically to Myeloproliferative Neoplasm Initiation Potential, and Accelerate Progression of Disease
Authors: Takafumi Shimizu, Hui Hao-Shen, Lucia Kubovcakova, Pontus Lundberg, Stephan Dirnhofer, Stuart H. Orkin, Jean Grisouard, Yukiko Shimizu, Annalisa Pianta, Barbara Szczerba, Ronny Nienhold, Radek C. Skoda
Journal: Blood (2014)
Tacrolimus and Indomethacin Are Safe and Effective at Reducing Pancreatitis After Endoscopic Retrograde Cholangiopancreatography in Patients Who Have Undergone Liver Transplantation
Authors: Nikhil R. Thiruvengadam, Kimberly A. Forde, Vinay Chandrasekhara, Nuzhat A. Ahmad, Gregory G. Ginsberg, Vandana Khungar, Michael L. Kochman
Journal: Clinical Gastroenterology and Hepatology (2019)
Biological Analysis and Prognostic Significance of Proliferative Cellular Compartment in Chronic Lymphocytic Leukemia (CLL).
Authors: Pau Abrisqueta, Neus Villamor, Ana Muntañola, Carles Codony, Mireia Camós, Eva Calpe, Maria Joao Baptista, Gonzalo Gutiérrez-García, Xavier Calvo, Rita Coutinho, Gabriela Ghita, Carol Moreno, Cristina Lopez, Olga Salamero, Emili Montserrat, Francesc Bosch
Journal: Blood (2009)
Identification of a Subgroup of Biphenotypic Myeloid/T-Cell Acute Leukemias with a CEBPA-Mutant Gene Expression Profile, Frequent CEBPA Promoter Hypermethylation and NOTCH1 Mutations.
Authors: Bas J. Wouters, Irene Louwers, Claudia A.J. Erpelinck-Verschueren, Peter J.M. Valk, Dennis Tielemans, Anton W. Langerak, Daniel G. Tenen, Warren S. Pear, Bob Lowenberg, Ruud Delwel
Journal: Blood (2006)
Profiling Genomic Alterations Of Diffuse Large B-Cell Lymphoma (DLBCL) At Diagnosis, Relapse, and Transformation, Using a Novel Clinical Diagnostic Targeted Sequencing Platform
Authors: Andrew M. Intlekofer, Venkatraman E. Sheshan, Ross L. Levine, Andrew D. Zelenetz, Julie Teruya-Feldstein, Ahmet Dogan, Maria Lia Palomba, Craig H. Moskowitz, Marcel R. M. van den Brink, Kristina M. Knapp, Amanda R. M. Copeland, Janine D. Pichardo, Kristina W. Brennan, Geneva Young, Jie He, Michelle K. Nahas, Roman Yelensky, Geoff A. Otto, Doron Lipson, Philip J. Stephens, Vincent A. Miller, Anas Younes
Journal: Blood (2013)
The future of drug-resistant tuberculosis treatment: learning from the past and the 2019 World Health Organization consolidated guidelines
Authors: José A. Caminero, Alberto L. García-Basteiro, Adrián Rendon, Alberto Piubello, Emanuele Pontali, Giovanni Battista Migliori
Journal: European Respiratory Journal (2019)

The World Health Organization (WHO) recently launched the consolidated guidelines on drug-resistant tuberculosis (DR-TB) treatment [1]. They include a new drug classification to manage rifampicin-resistant (RR) and multidrug-resistant (MDR)-TB, while proposing either a shorter regimen (including injectable drugs) or a longer all-oral one as the recommended treatment options. Efficient diagnostic tools are presently available to diagnose resistance to second-line drugs within a few hours (instead of the weeks previously needed) [2]. Therefore, the challenge for National TB Programmes is now to capture these new recommendations in their national guidelines. The aim of this article is to contribute to the ongoing discussion on RR-/MDR-TB treatment considering the lessons learnt over the past 70 years of anti-TB chemotherapy. Other important topics raised in the 2019 WHO drug-resistant treatment guidelines, such as the treatment of isoniazid-resistant TB or the comparison between the two WHO-approved regimens for MDR-TB, have not been addressed within the constraints of this short editorial. New shorter MDR-TB regimens based on drugs administered orally <http://bit.ly/2Nwg6lv> This article belongs to the scientific activities of the WHO Collaborating Centre for Tuberculosis and Lung Diseases, Tradate, ITA-80, 2017-2020- GBM/RC/LDA and the Global Tuberculosis Network (GTN, Committees on treatment, clinical trials and strategies).
SK053, an Inhibitor of Enzymes Involved in Allosteric Disulfide Bonds Formation, Targets Expression of Histone Genes and Induces Differentiation of Human AML Cell
Authors: Justyna Chlebowska, Pawel Gaj, Piotr Stawinski, Michal Lazniewski, Malgorzata Firczuk, Karolina Furs, Radoslaw Sadowski, Szymon Klossowski, Ryszard Ostaszewski, Jakub Golab, Krzysztof Giannopoulos, Rafal Ploski, Dominika Nowis
Journal: Blood (2014)
The Prevotella copri Complex Comprises Four Distinct Clades Underrepresented in Westernized Populations
Authors: Adrian Tett, Kun D. Huang, Francesco Asnicar, Hannah Fehlner-Peach, Edoardo Pasolli, Nicolai Karcher, Federica Armanini, Paolo Manghi, Kevin Bonham, Moreno Zolfo, Francesca De Filippis, Cara Magnabosco, Richard Bonneau, John Lusingu, John Amuasi, Karl Reinhard, Thomas Rattei, Fredrik Boulund, Lars Engstrand, Albert Zink, Maria Carmen Collado, Dan R. Littman, Daniel Eibach, Danilo Ercolini, Omar Rota-Stabelli, Curtis Huttenhower, Frank Maixner, Nicola Segata
Journal: Cell Host & Microbe (2019)

Prevotella copri is a common human gut microbe that has been both positively and negatively associated with host health. In a cross-continent meta-analysis exploiting >6,500 metagenomes, we obtained >1,000 genomes and explored the genetic and population structure of P. copri. P. copri encompasses four distinct clades (>10% inter-clade genetic divergence) that we propose constitute the P. copri complex, and all clades were confirmed by isolate sequencing. These clades are nearly ubiquitous and co-present in non-Westernized populations. Genomic analysis showed substantial functional diversity in the complex with notable differences in carbohydrate metabolism, suggesting that multi-generational dietary modifications may be driving reduced prevalence in Westernized populations. Analysis of ancient metagenomes highlighted patterns of P. copri presence consistent with modern non-Westernized populations and a clade delineation time pre-dating human migratory waves out of Africa. These findings reveal that P. copri exhibits a high diversity that is underrepresented in Western-lifestyle populations.
Evaluation of Graft Versus Host Disease and Relapse Free Survival As Novel Endpoint in Allogeneic Hematopoietic Stem Cell Transplantation: A Retrospective Joint Naples-Paris Study
Authors: Simona Pagliuca, Antonio M Risitano, Sylvie Chevret, Flore Sicre de Fontbrune, Alienor Xhaard, Tereza Coman, David Michonneau, Serena Marotta, Mathilde Ruggiu, Swann Bredin, Regis Peffault de Latour, Gérard Socié, Marie Robin
Journal: Blood (2016)
Changes In Health Status and Quality of Life In Parental Reports of Children with Thalassemia: Year 1 Report of the Thalassemia Longitudinal Cohort Study
Authors: Robert Yamashita, Amy Sobota, Felicia Trachtenberg, Yan Xu, Isaac Odame, Alexis A. Thompson, Patricia Giardina, Dru Haines, Zahra Pakbaz, Dorothy A Kleinert, Charles T. Quinn, Janet L Kwiatkowski, Leann Schilling, Jeanne Boudreaux, Ellis J. Neufeld
Journal: Blood (2010)
T-Cell Acute Lymphoblastic Leukemia Patients with Mutations in IL7Ra or Downstream RAS-MEK or PI3K-AKT Can be Collectively Targeted By Combination of RAS and AKT Inhibitors
Authors: Kirsten Canté-Barrett, Jill AP Spijkers-Hagelstein, Jessica GCAM Buijs-Gladdines, Wilco K Smits, Rogier C Buijsman, Guido JR Zaman, Rob Pieters, Jules PP Meijerink
Journal: Blood (2015)
Heterogeneous Bcl-2 Family Expression In Waldenström Macroglobulinemia Determines Response To Inducers Of Intrinsic Apoptosis
Authors: Brian T Gaudette, Kasyapa S. Chitta, Stephanie Poulain, Kelvin P Lee, Asher Chanan-Khan, Stephen M Ansell, Xavier Leleu, Sagar Lonial, Lawrence H. Boise
Journal: Blood (2013)
Measurable Amount of Active Thrombin Is Bound to Circulating D-Dimers. Is There Any Impact on Diagnosis and Pathophysiology of Thrombosis?
Authors: Jan E. Dyr, Jana Stikarova, Jiri Suttnar, Katerina Kuzelova, Pavel Sacha, Ondrej Kucerka, Jan Louzil, Jaroslav Cermak, Petr Soukup, Peter Salaj, Martin Hajsl, Martin Maly, Roman Kotlin
Journal: Blood (2016)
Differences in Outcomes in Males and Females with Diffuse Large B-Cell Lymphoma with Induction Rituximab and Follicular Lymphoma Treated with Maintenance Rituximab
Authors: Thomas M Habermann, Fangxin Hong, Vicki A. Morrison, Shaker R. Dakhil, James K. Weick, Stanley R. Frankel, Randy D. Gascoyne, Richard I Fisher, Bruce D. Cheson, Edie A. Weller, Brad S. Kahl, Bruce A. Peterson, Howard S Hochster, Sandra J. Horning
Journal: Blood (2012)
Efficacy of Fondaparinux in the Treatment of Heparin-Induced Thrombocytopenia with Venous Thromboembolism: Reduction of Thromboembolic Burden, Normalization of Platelet Count and Disappearance of Anti-Platelet Factor 4/Heparin Antibodies.
Authors: Franco Piovella, Marisa Barone, Chiara Beltrametti, Chiara Piovella, Andrea M. D’Armini, Federico Capra Marzani, Vittorio Arici, Mara De Amici, Stefano L. Barco, Gianluca Castellani, Martin Langer
Journal: Blood (2006)
An International Data Set for the Study of Chronic Myelomonocytic Leukemia (CMML) Validates Modern Prognostic Scoring Systems and Demonstrates a Critical Need for Novel Prognostication Strategies
Authors: Eric Padron, Guillermo Garcia-Manero, Mrinal M. Patnaik, Raphael Itzykson, Terra Lasho, Aziz Nazha, Raajit K. Rampal, Matias Eugenio Sanchez, Elias Jabbour, Najla H Al Ali, Zachary Thompson, Ji-Hyun Lee, Simona Colla, Pierre Fenaux, Hagop M. Kantarjian, Sally Killick, Mikkael A. Sekeres, Alan F List, Francesco Onida, Rami S Komrokji, Ayalew Tefferi, Eric Solary
Journal: Blood (2014)
Clinical Outcome of P-Gemox ( Pegaspargase, Gemcitabine, Oxaliplatin ) for the Patients with Newly Diagnosed Stage III/IV or Relapsed/Refractory Extranodal Natural Killer/T Cell Lymphoma
Authors: Huiqiang Huang, Yan Gao, XiaoXiao Wang, Qingqing Cai, QiChun Cai, Bing Bai, Wei Zhao, Zheng Yan, Wenqi Jiang, Zhongjun Xia, ZhiMing Li
Journal: Blood (2015)
Superiority of Pediatric Chemotherapy over Allogeneic Hematopoietic Cell Transplantation for Philadelphia Chromosome Negative Adult ALL in First Complete Remission: A Combined Analysis of Dana-Farber ALL Consortium and CIBMTR Cohorts
Authors: Matthew D. Seftel, Donna Neuberg, Mei-Jie Zhang, Hai-Lin Wang, Julie Bergeron, Stephen Couban, Daniel J. DeAngelo, Marcos J de Lima, Steven M. Devine, Mary Eapen, Mary M. Horowitz, Marcelo C. Pasquini, J. Douglas Rizzo, Wael Saber, Stephen E. Sallan, Brenda M. Sandmaier, Daniel J. Weisdorf
Journal: Blood (2014)
Revisiting Graft-Versus-Leukemia Effects after Umbilical Cord Blood Transplantation for Acute Myeloid Leukemia : A Report from Eurocord, the Acute Leukemia Working Party and the Cord Blood Committee of the Cellular Therapy &amp; Immunobiology Working Party of the European Society for Blood and Marrow Transplantation
Authors: Frederic Baron, Annalisa Ruggeri, Eric Beohou, Myriam Labopin, Mohamad Mohty, Jaime Sanz, Stéphane Vigouroux, Didier Blaise, Alberto Bosi, Patrice Chevalier, Jan J. Cornelissen, Mauricette Michallet, Jorge Sierra, Dimitrios Karakasis, Bipin N. Savani, Eliane Gluckman, Arnon Nagler
Journal: Blood (2016)
CD40 Pathway Activation Status Predicts Response to CD40 Targeted Therapy in Diffuse Large b-Cell Lymphoma.
Authors: David Dornan, Bart Burington, Peng Yue, Xiaoyan Shi, Ranjana Advani, Nancy Yu, Jeffrey T Lau, Shang-Fan Yu, Sven De Vos, Stephen M Ansell, Andres Forero-Torres, Zora Modrusan, Hartmut Koeppen, Teddy Yang, Changchun Du, Kristi Elkins, Andrew G. Polson, Rienk Offringa, Nancy Whiting, Allen J. Ebens
Journal: Blood (2009)
Risk Factors of Thromboembolic Events in Multiple Myeloma Treated with IMiDs-Based Therapy While on LMWH Prophylaxis,
Authors: Xavier Leleu, Simona Iacobelli, Alain Barrois, Benjamin Pelle, Liz Clark, Eileen Boyle, Philippe Moreau, Mamoun Dib, Denis Caillot, Dietger Niederwieser, Tamas Masszi, Jean Fontan, Chantal Doyen, Roman Hajek, Francesco Onida, Heinz Ludwig, Theo M. de Witte, Gosta Gahrton, Curly TCM Morris, Laurent Garderet
Journal: Blood (2011)
Comparison of Human Stem Cell Homing after Intravenous or Intra-Femoral Transplantation Using Multimodal In Vivo Imaging of Repopulating Human CD34+ Cells Labeled with Far-Red Fluorescent-Conjugated Nanoparticles.
Authors: Jesper Bonde, David A. Hess, Dustin J. Maxwell, Ryan Lahey, Michael H. Creer, David Piwnica-Worms, Jan A. Nolta
Journal: Blood (2005)
Targeting The PRMT5 Enzyme To Induce γ-Globin Gene Derepression In Sickle Cell Anemia
Authors: Necrisha Roach, Matthew Cannon, Dalia El-Gamal, Payal C Desai, Eric H. Kraut, James E. Bradner, Rosa Lapalombella, Robert A. Baiocchi
Journal: Blood (2013)
Glucocorticoid Therapy Targets Proliferation, Differentiation and Bcl-2 Dependent Survival Signaling in ALL Blasts.
Authors: Peter Rhein, Stefanie Scheid, Richard Ratei, Christian Hagemeier, Karl Seeger, Renate Kirschner-Schwabe, Martin Schrappe, Rainer Spang, Wolf-Dieter Ludwig, Leonid Karawajew
Journal: Blood (2006)
Upregulation of CXCR4 Is Essential for the Migration and Survival of Quiescent CML Progenitor Cells in the Bone Marrow Microenvironment after Imatinib Treatment.
Authors: Yoko Tabe, Linhua Jin, Sergej Konoplev, Lu Hongbo, Shinya Kimura, Mary-Beth Rios, Hagop M. Kantarjian, Michael Andreeff, Marina Konopleva
Journal: Blood (2007)
High Resolution Genome-Wide Analyses Revealed That Bortezomib Selects a Prediagnosis Clone In Relapsed Patients with Multiple Myeloma
Authors: Florence Magrangeas, Hervé Avet-Loiseau, Olivier Decaux, Wilfried Gouraud, jean Luc Harousseau, Kenneth C. Anderson, Philippe Moreau, Nikhil C. Munshi, Stephane Minvielle
Journal: Blood (2010)
Extracellular Vesicle microRNAs from Acute Myeloid Leukemia Are Involved in the Regulation of Adherence Junction in Bone Marrow Microenvironment.
Authors: Masahiro Yoshida, Masayoshi Kobune, Shogo Miura, Soushi Ibata, Satoshi Iyama, Tsutomu Sato, Kazuyuki Murase, Kohichi Takada, Kaoru Ono, Akari Hashimoto, Ayumi Tatekoshi, Yusuke Kamihara, Yusuke Sugama, Shohei Kikuchi, Hiroshi Ikeda, Hiroto Horiguchi, Yutaka Kawano, Koji Miyanishi, Hiroyuki Kuroda, Masahiro Maeda, Junji Kato
Journal: Blood (2016)
SIRT6 Inhibition As a Novel Approach for Treating Acute Myeloid Leukemia
Authors: Michele Cea, Antonia Cagnetta, Debora Soncini, Paola Minetto, Davide Lovera, Fabio Guolo, Nicoletta Colombo, Filippo Ballerini, Marino Clavio, Maurizio Miglino, Marco Gobbi, Roberto M Lemoli
Journal: Blood (2016)
Cooperation Between Aid and the Rag1/Rag2 V(D)J Recombinase Drives Clonal Evolution of Childhood Acute Lymphoblastic Leukemia
Authors: Srividya Swaminathan, Lars Klemm, Anthony M. Ford, Klaus Schwarz, Rafael Casellas, Lothar Hennighausen, Huimin Geng, David G. Schatz, Michael R. Lieber, Mel Greaves, Markus Muschen
Journal: Blood (2012)
TRAIL/ DR5 Interactions Are Important for Thymic Damage After Allogeneic Bone Marrow Transplantation.
Authors: Il-Kang Na, Sydney X Lu, Nury L. Yim, Gabrielle L. Goldberg, Jennifer Tsai, Uttam K. Rao, Odette M. Smith, Christopher King, David Suh, Daniel Hirschhorn-Cymerman, Maria Lia Palomba, Olaf Penack, Amanda M. Holland, Robert R. Jenq, Arnab Ghosh, Hien Tran, Taha Merghoub, Chen Liu, Greg Sempowski, Melissa Ventevogel, Nicole Beauchemin, Bruce Furie, Marcel R.M. van den Brink
Journal: Blood (2009)
Evidence for an Enhanced Fibrinolytic Capacity in Liver Cirrhosis Measured with a New Global Fibrinolysis Test in Whole Blood.
Authors: Frank W.G. Leebeek, Edith L. Kock, Ana H. Guimaraes, Sarwa D. Murad, Harry L. Janssen, Dingemans C. Rijken
Journal: Blood (2006)
The Prognostic Value of Serum APRIL Levels in Patients with Chronic Lymphocytic Leukemia
Authors: Sinem Nihal Esatoglu, Dilek Keskin, Muge Kutnu, Tugrul Elverdi, Ayse Salihoglu, Ahmet Emre Eskazan, Muhlis Cem AR, Seniz Ongoren Aydin, Zafer Baslar, Yildiz Aydin, Hanife Uzun, Teoman Soysal
Journal: Blood (2014)
Primary Mediastinal Large B-Cell Lymphoma (PMBL) Outcome May Be Significantly Improved by the Addition of Rituximab to Dose-Adjusted (DA)-EPOCH and Obviates the Need for Radiation: Results from a Prospective Study of 44 Patients.
Authors: Kieron Dunleavy, Stefania Pittaluga, John Janik, Nicole Grant, Margaret Shovlin, Seth Steinberg, Mark Raffeld, Louis Staudt, Elaine S. Jaffe, Wyndham H. Wilson
Journal: Blood (2006)
A CK2-Dependent Mechanism for PML Degradation upon Cellular and Oncogenic Stress.
Authors: Pier P. Scaglioni, Thomas M. Yung, Lu F. Cai, Hediye Erdjument-Bromage, Andrew J. Kaufman, Bhuvanesh Singh, Julie Teruya-Feldstein, Paul Tempst, Pier Paolo Pandolfi
Journal: Blood (2006)
Combined Donor and Recipient Non-HLA Genotypes Show Evidence of Genome Wide Association with Transplant Related Mortality (TRM) after HLA-Matched Unrelated Donor Blood and Marrow Transplantation (URD-BMT) (DISCOVeRY-BMT study)
Authors: Lara E. Sucheston-Campbell, Leah Preus, Marcelo C. Pasquini, Philip L. McCarthy, Kenan Onel, Xiaochun Zhu, Stephen R. Spellman, Christopher Haiman, Daniel O. Stram, Loreall Pooler, Xin Sheng, Qianqian Zhu, Li Yan, Qian Liu, Qiang Hu, Song Liu, Alyssa I. Clay, Sebastiano Battaglia, David Tritchler, Theresa Hahn
Journal: Blood (2015)
ZFN-Mediated Gene Targeting at the Albumin Locus in Liver Results in Therapeutic Levels of Human FIX in Mice and Non-Human Primates
Authors: Thomas Wechsler, Kathleen E. Meyer, S. Kaye Spratt, Judith Greengard, Yolanda Santiago, Scott Sproul, Richard Surosky, David E. Paschon, Nathalie Dubois-Stringfellow, Dale Genji Ando, Geoff Nichol, Edward J. Rebar, Michael C. Holmes
Journal: Blood (2015)
Effects of Intensive Versus Standard Ambulatory Blood Pressure Control on Cerebrovascular Outcomes in Older People (INFINITY)
Authors: William B. White, Dorothy B. Wakefield, Nicola Moscufo, Charles R.G. Guttmann, Richard F. Kaplan, Richard W. Bohannon, Douglas Fellows, Charles B. Hall, Leslie Wolfson
Journal: Circulation (2019)

Subcortical microvascular disease represented by brain white matter hyperintensity on magnetic resonance imaging is associated with functional decline in older people with hypertension. The effects of 2 levels of 24-hour average systolic blood pressure (BP) on mobility, white matter disease progression, and cognitive function over 3 years were studied.This trial was a prospective, randomized, blinded end-points study in patients ≥75 years of age with systolic hypertension and magnetic resonance imaging evidence of white matter hyperintensity lesions. Patients were randomized to a 24-hour mean systolic BP of ≤130 mm Hg (intensive treatment) versus ≤145 mm Hg (standard treatment) with antihypertensive therapies. Primary study outcomes were changes in mobility (gait speed) and accrual of white matter hyperintensity volume after 3 years. Changes in cognitive function (executive processing) and adverse events were also evaluated.In 199 randomized patients, the mean age of the cohort was 80.5 years, and 54% were women; the average 24-hour systolic BP was 149 mm Hg. Goal BPs were achieved after a median treatment period of 3 to 4 months; at that time, the mean 24-hour systolic BP was 127.7 mm Hg in the intensive treatment group and 144.0 mm Hg in the standard treatment group for an average difference of 16.3 mm Hg. Changes in gait speed were not different between treatment groups (0.40±2.0 versus 0.42±2.7 s in the intensive treatment and standard treatment groups, respectively; P=0.91), whereas changes from baseline in white matter hyperintensity volumes were smaller (0.29%) in the intensive treatment group compared with the standard treatment group (0.48%; P=0.03). Cognitive outcomes also were not different between the treatment groups. Major adverse cardiovascular events were higher in the standard treatment group compared with the intensive treatment group (17 versus 4 patients; P=0.01). Falls, with or without injury, and syncope were comparable in the treatment groups.Intensive lowering of ambulatory BP reduction in older patients with hypertension did not result in differences in mobility outcomes but was associated with a reduction in accrual of subcortical white matter disease. Over periods >3 years, a reduction in the accumulation of white matter disease may be a factor in conserving function.URL: https://www.clinicaltrials.gov. Unique identifier: NCT01650402.
Impact of FLT3 Internal Tandem Duplication (FLT3/ITD) on the Outcome of HLA-Identical Sibling Hematopoietic Transplantation for Adult Acute Myeloid Leukemia (AML) in First Remission: Substantial Probability of Leukemia-Free Survival Despite Increased Relapse Risk. A Retrospective Analysis of the EBMT-ALWP.
Authors: Salut Brunet, Myriam Labopin, Jan J. Cornelissen, Gérard Socié, Ana Paola Iori, Leo F. Verdonck, Tapani Ruutu, Alois Gratwohl, Jean-Luc Harousseau, Jorge Sierra, Vanderson Rocha
Journal: Blood (2007)