tbuckley/cabot-search huggingface dataset:
Relationships among health-related quality of life indicators in cancer patients: A pooled study of baseline EORTC QLQ-C30 data from 6,739 patients
Authors: F. Martinelli, C. Quinten, C. Coens, H. Flechtner, C. Gotay, T. Mendoza, D. Osoba, B. Reeve, X. Wang, A. Bottomley
Journal: Journal of Clinical Oncology (2009)

9612 Background: Cancer patients frequently experience multiple and co-occuring problems due to their illness and therapies. Clusters are defined as groups of two or more Health-Related Quality of Life (HRQoL) indicators that occur concurrently and may or may not have a common related cause. The objective of this meta-analysis was to identify how HRQoL indicators cluster among cancer patients. Methods: Retrospective pooling of 29 European Organisation for Research and Treatment of Cancer (EORTC) randomized clinical trials, among 10 cancer sites, yielded baseline EORTC QLQ-C30 HRQoL data for a total of 6739 patients. A cluster analysis was performed to identify clusters among the 15 HRQoL scales, via Ward's method. Cronbach's alpha coefficient (α) was used to measure internal consistency. Dendrograms of the HRQoL indicators were plotted for the overall data and for each cancer site. Results: Three main clusters emerged from the pooled dataset: a physical function-related cluster, consisting of physical and role functioning, fatigue and pain (α = 0.83); a psychological function-related cluster, consisting of emotional and cognitive functioning and insomnia (α = 0.64); and a gastrointestinal cluster, consisting of nausea and vomiting and appetite loss (α = 0.68). The same clusters were found in patients with metastatic and non-metastatic disease. The gastrointestinal cluster was reproduced in all 10 cancer sites. We found that pain was not correlated with the other variables of the physical function cluster for patients with brain, colorectal or pancreatic cancer. For the psychological component cluster, cognitive functioning was not correlated with the other variables of the cluster for breast or pancreatic cancer patients, while insomnia was found not to be correlated with the other variables of the cluster for prostate cancer patients. Conclusions: This study shows that relationships among HRQoL indicators exist and that three major constructs can be found: a physical, a psychological and a gastrointestinal component. Understanding these relationships may aid diagnostic criteria, and assessment, management, and prioritization of symptom care. No significant financial relationships to disclose.
Sustained Low-Density Lipoprotein Cholesterol Lowering With Alirocumab in ODYSSEY OUTCOMES
Authors: Shaun G. Goodman, Philippe Gabriel Steg, Michael Szarek, Deepak L. Bhatt, Vera A. Bittner, Rafael Diaz, Robert A. Harrington, J. Wouter Jukema, Harvey D. White, Andreas M. Zeiher, Gregory G. Schwartz
Journal: Journal of the American College of Cardiology (2020)

In the ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) trial, 18,924 patients with a recent acute coronary syndrome (ACS) not at lipid goals despite maximally tolerated statin therapy were randomized to alirocumab or placebo
Adult T-cell acute lymphoblastic leukemias with IL7R pathway mutations are slow-responders who do not benefit from allogeneic stem-cell transplantation
Authors: Rathana Kim, Nicolas Boissel, Aurore Touzart, Thibaut Leguay, Florian Thonier, Xavier Thomas, Emmanuel Raffoux, Françoise Huguet, Patrick Villarese, Cécile Fourrage, Loïc Passini, Mathilde Hunault, Stéphane Lepretre, Patrice Chevallier, Thorsten Braun, Véronique Lhéritier, Sylvain Chantepie, Sébastien Maury, Martine Escoffre, Emmanuelle Tavernier, Yves Chalandon, Carlos Graux, Elizabeth Macintyre, Norbert Ifrah, Vahid Asnafi, Hervé Dombret, Ludovic Lhermitte
Journal: Leukemia (2020)
Abstract 166: Physiological Effects of Adrenaline in Human Cardiac Arrest With Pulseless Electrical Activity: A Pilot Study
Authors: Magnus Bakke, Alexander Borgen, Anders Norvik, Gunnar W Skjeflo, Unai Irusta, Tomas Dybos Tannvik, Daniel Bergum, Elisabete Aramendi, Trygve Eftestol, Eirik Skogvoll
Journal: Circulation (2019)

Introduction: During resuscitation from cardiac arrest with Pulseless Electrical Activity (PEA), studies show that adrenaline facilitates return of spontaneous circulation (ROSC) and possibly leads to an isolated increase in the heart rate (HR). In this study, we investigated the immediate effects of adrenaline on ECG characteristics; HR and QRS duration (duration of ventricle depolarization). Method: We studied 19 ECG segments of 300 s duration from emergency defibrillators in 10 adult patients during resuscitation from in-hospital cardiac arrest. Information on the exact timing of adrenaline administration (between 0.5 and 1 mg i.v.) was obtained from the defibrillators or the emergency personnel involved. HR (1/min) and QRS duration (ms) were annotated and registered using an ad-hoc Matlab (Mathworks, Natic, MA) graphical Data Annotator, and interpolated linearly between individual observations. Trends were identified with LOWESS. Results: The plots show the individual observations (red points) along with the trends (blue lines) of HR and QRS Duration during resuscitation, relative to the time of adrenaline administration. We observed a gradual increase in heart rate (peaking at 150 s after adrenaline administration) and a more pronounced narrowing of the QRS (levelling off also at about 150 s). Discussion: In this pilot study, administration of adrenaline was associated with narrowing of the QRS complex, while the relation to heart rate was less apparent. A limitation is that no adjustment for the individual patient’s trajectory was made. However, the results are fairly consistent with earlier studies on out-of-hospital resuscitation, when adrenaline was typically given much later.
比較的保存されたLV収縮を伴う患者における心筋梗塞後の駆出分画へのβ-遮断薬とACE阻害剤のの早期投与 | 文献情報 | J-GLOBAL 科学技術総合リンクセンター
Authors: Atsuchi N, Nakao K, Kobayashi H, Nozaki K, Arai K, Hayashi M, Oka H, Tayama S, Honda T
Journal: Circulation (2002)
Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia
Authors: Juan Tang, Sha Tu, Guoxin Lin, Hui Guo, Chengkai Yan, Qingjun Liu, Ling Huang, Na Tang, Yizhi Xiao, R. Marshall Pope, Murugesan V.S. Rajaram, Amal O. Amer, Brian M. Ahmer, John S. Gunn, Daniel J. Wozniak, Lijian Tao, Vincenzo Coppola, Liwen Zhang, Wallace Y. Langdon, Jordi B. Torrelles, Stanley Lipkowitz, Jian Zhang
Journal: The Journal of Experimental Medicine (2020)

Aberrant NLRP3 inflammasome activation contributes to the development of endotoxemia. The importance of negative regulation of NLRP3 inflammasomes remains poorly understood. Here, we show that the E3 ubiquitin ligase Cbl-b is essential for preventing endotoxemia induced by a sub-lethal dose of LPS via a caspase-11/NLRP3–dependent manner. Further studies show that NLRP3 undergoes both K63- and K48-linked polyubiquitination. Cbl-b binds to the K63-ubiquitin chains attached to the NLRP3 leucine-rich repeat domain (LRR) via its ubiquitin-associated region (UBA) and then targets NLRP3 at K496 for K48-linked ubiquitination and proteasome-mediated degradation. We also identify RNF125 as an additional E3 ubiquitin ligase that initiates K63-linked ubiquitination of the NLRP3 LRR domain. Therefore, NLRP3 is sequentially ubiquitinated by K63- and K48-linked ubiquitination, thus keeping the NLRP3 inflammasomes in check and restraining endotoxemia.
Malpractice Liability and Quality of Care
Authors: William M. Sage, Kristen Underhill
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
COVID-19 Disease due to SARS-CoV-2 (Novel Coronavirus)
Authors: W. Graham Carlos, Charles S. Dela Cruz, Bin Cao, Susan Pasnick, Shazia Jamil
Journal: American Journal of Respiratory and Critical Care Medicine (2020)

"COVID-19 Disease due to SARS-CoV-2 (Novel Coronavirus)." American Journal of Respiratory and Critical Care Medicine, 201(4), pp. P7–P8
The Implications of Early Adversity Even Before Birth
Authors: Charles A. Nelson
Journal: JAMA Network Open (2020)

Yao Wu, PhD; Yuan-Chiao Lu, PhD; Marni Jacobs, PhD; Subechhya Pradhan, PhD; Kushal Kapse, MS; Li Zhao, PhD; Nickie Niforatos-Andescavage, MD; Gilbert Vezina, MD; Adré J. du Plessis, MBChB; Catherine Limperopoulos, PhD
How to stop the dying, as well as the killing, in a terrorist attack
Authors: Claire L Park, Matthieu Langlois, E Reed Smith, Matt Pepper, Michael D Christian, Gareth E Davies, Gareth R Grier
Journal: BMJ (2020)

There's a therapeutic vacuum in the "hot zone" of a terror attack. <b>Claire Park and colleagues</b> describe efforts in the UK and beyond to deliver expert medical care to casualties trapped at the centre of an attack
Abstract 18: Trends in Median CPR Duration Over Time in Patients With and Without Return of Spontaneous Circulation
Authors: Katherine M Berg, Michael Donnino, Ari Moskowitz, Mathias J Holmberg, Sebastian Wiberg, Anne V Grossestreuer
Journal: Circulation (2019)

Introduction: Survival after in-hospital cardiac arrest (IHCA) is increasing. In the Get-With-The-Guidelines-Resuscitation (GWTG-R) registry, longer median CPR duration in patients not achieving ROSC is associated with higher survival rates at the hospital level. We analyzed trends over time in median CPR duration by hospital in patients who achieved ROSC and those who did not, and stratified this analysis by age, gender and race. Methods: We included adult IHCA cases in GWTG-R from 2001-2017, excluding data from a given hospital and year if fewer than 5 eligible arrests were recorded. A nonparametric test for trend was done to evaluate median CPR duration over time in those with and without ROSC, in all patients and in groups stratified by age (&lt;60, 61-80 and &gt;80 years), gender, and race (white and black). Linear regression was done to evaluate the amount of change per year. Association with survival was tested using Pearsons correlation. Results: Of 359,107 IHCA events, 31,189 were excluded, leaving 327,918 for analysis. Over time, there was a significant increase in median CPR duration in patients who did not achieve ROSC, and a decrease in those who did attain ROSC.(Fig.) These trends persisted when stratified by gender, race and age. Each year was associated with a decrease in median CPR duration of 0.37 min (95% CI -0.41 to -0.33 min) in those with ROSC and an increase of 0.29 min (95% CI 0.25 to 0.33 min) in those without. There was a small but significant correlation between median CPR duration in those without ROSC and adjusted survival by hospital over time (r=0.224, p&lt;0.0001). Conclusions: In the GWTG-R registry, median duration of CPR is decreasing over time in patients achieving ROSC, but increasing in those not achieving ROSC. The increasing trend in CPR duration in those without ROSC correlates positively with the trend in survival. Whether the increase in median CPR duration in those without ROSC is contributing causally to improvements in survival warrants further study.
Increased antitumor efficacy of PD-1-deficient melanoma-specific human lymphocytes
Authors: Lucine Marotte, Sylvain Simon, Virginie Vignard, Emilie Dupre, Malika Gantier, Jonathan Cruard, Jean-Baptiste Alberge, Melanie Hussong, Cecile Deleine, Jean-Marie Heslan, Jonathan Shaffer, Tiffany Beauvais, Joelle Gaschet, Emmanuel Scotet, Delphine Fradin, Anne Jarry, Tuan Nguyen, Nathalie Labarriere
Journal: Journal for ImmunoTherapy of Cancer (2020)

Background Genome editing offers unique perspectives for optimizing the functional properties of T cells for adoptive cell transfer purposes. So far, PDCD1 editing has been successfully tested mainly in chimeric antigen receptor T (CAR-T) cells and human primary T cells. Nonetheless, for patients with solid tumors, the adoptive transfer of effector memory T cells specific for tumor antigens remains a relevant option, and the use of high avidity T cells deficient for programmed cell death-1 (PD-1) expression is susceptible to improve the therapeutic benefit of these treatments. Methods Here we used the transfection of CAS9/sgRNA ribonucleoproteic complexes to edit PDCD1 gene in human effector memory CD8 + T cells specific for the melanoma antigen Melan-A. We cloned edited T cell populations and validated PDCD1 editing through sequencing and cytometry in each T cell clone, together with T-cell receptor (TCR) chain’s sequencing. We also performed whole transcriptomic analyses on wild-type (WT) and edited T cell clones. Finally, we documented in vitro and in vivo through adoptive transfer in NOD scid gamma (NSG) mice, the antitumor properties of WT and PD-1KO T cell clones, expressing the same TCR. Results Here we demonstrated the feasibility to edit PDCD1 gene in human effector memory melanoma-specific T lymphocytes. We showed that PD-1 expression was dramatically reduced or totally absent on PDCD1 -edited T cell clones. Extensive characterization of a panel of T cell clones expressing the same TCR and exhibiting similar functional avidity demonstrated superior antitumor reactivity against a PD-L1 expressing melanoma cell line. Transcriptomic analysis revealed a downregulation of genes involved in proliferation and DNA replication in PD-1-deficient T cell clones, whereas genes involved in metabolism and cell signaling were upregulated. Finally, we documented the superior ability of PD-1-deficient T cells to significantly delay the growth of a PD-L1 expressing human melanoma tumor in an NSG mouse model. Conclusion The use of such lymphocytes for adoptive cell transfer purposes, associated with other approaches modulating the tumor microenvironment, would be a promising alternative to improve immunotherapy efficacy in solid tumors.
Abstract 218: Therapeutic Hypothermia Alone and Combination With Preconditioning Blunt Inflammation in Experimental Hemorrhagic Shock
Authors: Jianru Shi, Wangde Dai, Juan Carreno, Sharon L Hale, Robert A Kloner
Journal: Circulation (2019)

Background: Recent studies by our group indicate that preconditioning, therapeutic hypothermia (TH) and TH combined with preconditioning improved long-term survival during resuscitation of hemorrhagic shock. The neutrophil-to-lymphocyte ratio (NLR) is a marker of inflammation associated with increased mortality in patients with severe hemorrhage shock. The aim of this study is to evaluate the effects of these three therapies on NLR level in rats with acute hemorrhagic shock. Methods and Results: In the preconditioning study, Sprague Dawley rats (both genders) were randomized to preconditioning (n=26) or control group (n=27); in the hypothermia study, rats were randomized to TH (n=16) or control group (n=15); in a combination study, rats were randomized to TH plus preconditioning (n=11) or control group (n=10). Rats were anesthetized with intraperitoneal Ketamine and xylazine. After heparinizing, hemorrhagic shock was induced by withdrawing blood to a fixed mean blood pressure (MBP) of 30 mmHg for 30 minutes and then shed blood was reinfused. Preconditioning was induced by 4 cycles of inflating small cuffs around the femoral arteries to 200 mmHg for 5 minutes, followed by 5-minute deflation of the cuffs prior to hemorrhagic shock. TH started at 5 minutes after MBP reached 30 mmHg. Core temperature was maintained at ~32 °C until blood volume was fully restored. In the control group, body temperature was maintained at ~ 37°C. Arterial blood samples were collected 1 hour after resuscitation. The NLR is an easily accessible biomarker, which is calculated by dividing the absolute neutrophil count by the absolute lymphocyte count. The NLR was significantly lower in TH group (0.20 ± 0.02) compared with the control group (0.32 ± 0.03; p=0.003). Similarly, the NLR level was significantly decreased in TH plus preconditioning group (0.19 ± 0.02) versus the control group (0.33 ± 0.02; p= 0.001). There was no difference in NLR level between the preconditioning group (0.41 ± 0.04) and the control group (0.41 ± 0.04; p=0.984). Conclusions: NLR is widely recognized inflammation marker associated with poor prognosis in severe hemorrhagic shock. TH alone and TH combined with preconditioning blunt the inflammation by decreasing the NLR level in experimental hemorrhagic shock.
Methodological Flaws in Improving Physician Role Identification via “Doctor” Badges—Reply
Authors: Michael B. Foote, Ersilia M. DeFilippis, Maria A. Yialamas
Journal: JAMA Internal Medicine (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Firgem, A Sequential Folfiri.3 (CPT-11 Plus Folinic Acid Plus 5-FU) Followed by Gemcitabine or Gemcitabine Alone in Patients with Previously Untreated Metastatic Pancreatic Adenocarcinoma: Results of a Randomized Multicenter Ageo Phase II Trial
Authors: I. Trouilloud, A.C. Dupont-Gossard, P. Artru, T. Lecomte, M. Gauthier, T. Aparicio, A. Thirot-Bidault, D. Malka, F. Bonnetain, J. Taieb
Journal: Annals of Oncology (2012)
Practical Guide to Comparative Effectiveness Research Using Observational Data
Authors: Ryan P. Merkow, Todd A. Schwartz, Avery B. Nathens
Journal: JAMA Surgery (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Endoscopic transpapillary biopsy using a self-assembled device: the tunnel technique
Authors: Vincenzo Perri, Beatrice Orlandini, Andrea Tringali, Ivo Boškoski, Guido Costamagna
Journal: Endoscopy (2020)

Endoscopic transpapillary biopsy under fluoroscopic control is a well-established method for tissue sampling in the case of biliary stenosis during endoscopic retrograde cholangiopancreatography (ERCP). Nevertheless, some adverse events and technical challenges, especially in proximal strictures, have been reported [1]. Cholangioscopy-guided biopsy remains an expensive, niche technique with small-sized forceps, making histological analysis difficult [2]. Finding a safe, cost-effective technique for histology remains a challenge. Herein we report a new technique for transpapillary biopsy using a biliary dilation catheter.
Art in Endoscopy: “Pretty Pink”
Authors: Jeroen de Groof, Jacques Bergman
Journal: Endoscopy (2020)

In this image, we clearly see a vertical demarcation line of a neoplastic lesion in a Barrett’s esophagus, visualized in linked color imaging in magnification mode. This optical chromoscopy technique is integrated into the Fujifilm ELUXEO 7000 endoscopy system and has been developed to enhance color differences in the mucosa, focusing on increased discrimination of red colors.
Glutathione-responsive disassembly of disulfide dicyanine for tumor imaging with reduction in background signal intensity
Authors: Shanyan Mo, Xiaoting Zhang, Sadaf Hameed, Yiming Zhou, Zhifei Dai
Journal: Theranostics (2020)

Near-infrared (NIR) fluorescence imaging has been proved as an effective modality in identifying the tumor border and distinguishing the tumor cells from healthy tissue during the oncological surgery. Developing NIR fluorescent probes with high tumor to background (T/B) signal is essential for the complete debulking of the tumor, which will prolong the survival rate of tumor patients. However, the nonspecific binding and "always-on" properties of the conventional fluorescent probes leads to high background signals and poor specificity. Method: To address this problem, glutathione (GSH)-responsive, two disulfide-bonded dicyanine dyes (ss-diCy5 and ss-diNH800CW) were synthesized. As synthesized dyes are quenched under normal physiological conditions, however, once reached to the tumor site, these dyes are capable of emitting strong fluorescence signals primarily because of the cleavage of the disulfide bond in the tumor microenvironment with high GSH concentration. Besides, the GSH-responsive behavior of these dyes was monitored using the UV-vis and fluorescence spectroscopy. The diagnostic accuracy of the aforementioned dyes was also tested both in tumor cells and 4T1-bearing mice. Results: The fluorescence signal intensity of disulfide dicyanine dyes was quenched up to 89% compared to the mono cyanine dyes, thus providing a very low fluorescence background. However, when the disulfide dicyanine dye reaches the tumor site, the dicyanine is cleaved by GSH into two mono-dyes with high fluorescence strength, thus producing strong fluorescent signals upon excitation. The fluorescent signal of the dicyanine was enhanced by up to 27-fold after interacting with the GSH solution. In vivo xenografts tumor studies further revealed that the fluorescence signals of aforementioned dyes can be quickly recovered in the solid tumor. Conclusion: In summary, the disulfide dicyanines dyes can provide a promising platform for specific tumor-activatable fluorescence imaging with improved T/B value.