tbuckley/cabot-search huggingface dataset:
Creatine Phosphokinase
Authors: David Halbersleben
Journal: JAMA (1974)

<h3>To the Editor.—</h3> The report of persistently high creatine phosphokinase serum levels and of high levels in single determinations in ten college football players of similar large muscle mass may be of considerable value for study of patients of similar build. Other points to which I call attention are the statements (1) "the only abnormality noted in the electrocardiogram was flattening of the T waves in lead V<sub>6</sub>..." (2) "the electrocardiogram returned to normal on the third day," and (3) "the patient was discharged after the fourth day with a diagnosis of chest wall pain, probably osteochondritis aggravated by acute anxiety." The T waves of the ECG are one
AN ARTICLE CONTRIBUTED TO AN ANNIVERSARY VOLUME IN HONOR OF DOCTOR JOSEPH HERSEY PRATT
Authors: Charles H. Lawrence
Journal: Annals of Internal Medicine (2020)

Excerpt In his paper on tumors of the suprarenal cortex read before the Staff of the Mayo Clinic in 1933, Kepler1cites the following quotation from Rowntree and Ball: We may say that there are var...
10P Prediction of the 21-gene recurrence score by a non-genomic approach in stage I estrogen receptor-positive, HER2-negative breast cancer
Authors: F. Le Du, F. Takeo, M. Park, K.R. Hess, D. Liu, R. Jackson, C. Mylander, M. Rosman, A. Raghavendra, L. Tafra, N.T. Ueno
Journal: Annals of Oncology (2020)
Analytical validation of the Immunoscore and its associated prognostic value in patients with colon cancer
Authors: Florence Marliot, Xiaoyi Chen, Amos Kirilovsky, Thomas Sbarrato, Carine El Sissy, Luciana Batista, Marc Van den Eynde, Nacilla Haicheur-Adjouri, Maria-Gabriela Anitei, Ana-Maria Musina, Viorel Scripcariu, Christine Lagorce-Pagès, Fabienne Hermitte, Jérôme Galon, Jacques Fieschi, Franck Pagès
Journal: Journal for ImmunoTherapy of Cancer (2020)

Background New and fully validated tests need to be brought into clinical practice to improve the estimation of recurrence risk in patients with colon cancer. The aim of this study was to assess the analytical performances of the Immunoscore (IS) and show its contribution to prognosis prediction. Methods Immunohistochemical staining of CD3+ and CD8+ T cells on adjacent sections of colon cancer tissues were quantified in the core of the tumor and its invasive margin with dedicated IS modules integrated into digital pathology software. Staining intensity across samples collected between 1989 and 2016 (n=595) was measured. The accuracy of the IS workflow was established by comparing optical and automatic counts. Analytical precision of the IS was evaluated within individual tumor block on distant sections and between eligible blocks. The IS interlaboratory reproducibility (n=100) and overall assay precision were assessed (n=3). Contribution of the IS to prediction of recurrence based on clinical and molecular parameters was determined (n=538). Results Optical and automatic counts for CD3+ or CD8+ were strongly correlated (r=0.94, p&lt;0.001 and r=0.92, p&lt;0.001, respectively). CD3 and CD8 staining intensities were not altered by the age of the tumor block over a period of 30 years. Neither the position of tested tissue sections within a tumor block nor the selection of the tissue blocks affected the IS. Reproducibility of the IS was not affected by multiple variables (eg, antibody lots, DAB revelation kits, immunohistochemistry automates and operators). Interassay repeatability of the IS was 100% and interlaboratory reproducibility between two testing centers was 93%. Finally, in a case series of patients with stage II–III colon cancer, the relative proportion of variance for time to recurrence was greatest for the IS (53% of prognostic variability) in a model that included IS, T-stage, microsatellite instability status and total number of lymph nodes. Conclusion IS is a robust and validated clinical assay leveraging immune scoring to predict recurrence risk of patient with localized colon cancer. The strong and independent prognostic value of IS should pave the way for it use in clinical practice.
Impact of delayed diagnoses at the time of COVID-19: increased rate of preventable bilateral blindness in giant cell arteritis
Authors: Sara Monti, Paolo Delvino, Elisa Bellis, Alessandra Milanesi, Fabio Brandolino, Carlomaurizio Montecucco
Journal: Annals of the Rheumatic Diseases (2020)

<h3>BACKGROUND AND PURPOSE:</h3> FUS-induced BBB opening is a promising technique for noninvasive and local delivery of drugs into the brain. Here we propose the novel use of a neuronavigation system to guide the FUS-induced BBB opening procedure and investigate its feasibility in vivo in large animals. <h3>MATERIALS AND METHODS:</h3> We developed an interface between the neuronavigator and FUS to allow guidance of the focal energy produced by the FUS transducer. The system was tested in 29 swine by more than 40 sonication procedures and evaluated by MR imaging. Gd-DTPA concentration was quantitated in vivo by MR imaging R1 relaxometry and compared with ICP-OES assay. Brain histology after FUS exposure was investigated using H&amp;E and TUNEL staining. <h3>RESULTS:</h3> Neuronavigation could successfully guide the focal beam, with precision comparable to neurosurgical stereotactic procedures (2.3 ± 0.9 mm). A FUS pressure of 0.43 MPa resulted in consistent BBB opening. Neuronavigation-guided BBB opening increased Gd-DTPA deposition by up to 1.83 mmol/L (a 140% increase). MR relaxometry demonstrated high correlation with ICP-OES measurements (<i>r</i><sup>2</sup> = 0.822), suggesting that Gd-DTPA deposition can be directly measured by imaging. <h3>CONCLUSIONS:</h3> Neuronavigation provides sufficient precision for guiding FUS to temporally and locally open the BBB. Gd-DTPA deposition in the brain can be quantified by MR relaxometry, providing a potential tool for the in vivo quantification of therapeutic agents in CNS disease treatment.
179TiP EMERALD: A randomized, open-label, phase III trial to evaluate the efficacy and safety of elacestrant (RAD1901), a novel oral selective estrogen receptor degrader (SERD), vs investigator’s choice of endocrine therapy for ER+/HER2- advanced breast cancer following CDK4/6 inhibitor therapy
Authors: A. Bardia, J. Lu, V. Kaklamani, J. Jung, A.T. Anderson-Villaluz, M.G. Conlan, F-C. Bidard, J. Cortés, P.G. Aftimos
Journal: Annals of Oncology (2020)
Impact of clinical syndrome acuity on the differential response to two glycoprotein IIb/IIIa inhibitors in patients undergoing coronary stenting: the TARGET trial
Authors: Gregg W. Stone, David J. Moliterno, Michel Bertrand, Franz-Joseph Neumann, Howard C. Herrmann, Eric R. Powers, Cindy L. Grines, David J. Cohen, Eric A. Cohen, Marc Cohen, Marion Piedmonte, Pete M. DiBattiste
Journal: Journal of the American College of Cardiology (2002)
Cutaneous larva migrans: clinical features and management of 44 cases presenting in the returning traveller
Authors: V. Blackwell, F. Vega-Lopez
Journal: British Journal of Dermatology (2008)

Journal Article Cutaneous larva migrans: clinical features and management of 44 cases presenting in the returning traveller Get access V. Blackwell, V. Blackwell Department of Dermatology, Middlesex Hospital and Hospital for Tropical Diseases, University College London Hospitals Trust, Arthur Stanley House, Tottenham Street, London W1P 9PG, U.K. Search for other works by this author on: Oxford Academic Google Scholar F. Vega‐Lopez F. Vega‐Lopez Department of Dermatology, Middlesex Hospital and Hospital for Tropical Diseases, University College London Hospitals Trust, Arthur Stanley House, Tottenham Street, London W1P 9PG, U.K. Dr Francisco Vega‐Lopez. E‐mail: franciscovegalop@cs.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 145, Issue 3, 1 September 2001, Pages 434–437, https://doi.org/10.1111/j.1365-2133.2001.04406.x Published: 01 September 2001
BpForms and BcForms: a toolkit for concretely describing non-canonical polymers and complexes to facilitate global biochemical networks
Authors: Paul F. Lang, Yassmine Chebaro, Xiaoyue Zheng, John A. P. Sekar, Bilal Shaikh, Darren A. Natale, Jonathan R. Karr
Journal: Genome biology (2020)

Abstract Non-canonical residues, caps, crosslinks, and nicks are important to many functions of DNAs, RNAs, proteins, and complexes. However, we do not fully understand how networks of such non-canonical macromolecules generate behavior. One barrier is our limited formats for describing macromolecules. To overcome this barrier, we develop BpForms and BcForms , a toolkit for representing the primary structure of macromolecules as combinations of residues, caps, crosslinks, and nicks. The toolkit can help omics researchers perform quality control and exchange information about macromolecules, help systems biologists assemble global models of cells that encompass processes such as post-translational modification, and help bioengineers design cells.
Abstract 11226: Dexmedetomidine Reduces Circulating Microparticles-induced Chemotaxis of Neutrophils Through Foxo3a Pathway
Authors: Jingsong Ou, Cai Yun Chen, Hao-Xiang Yuan, Yu-Quan Li, Yan Li, Zhijun Ou, Kang-Qing Xu
Journal: Circulation (2019)

Introduction: We have previously reported that circulating microparticles (MPs) from before and after valvular heart diseases surgery can inhibit endothelium-dependent vasodilation. However, the ef...
6P Circulating tumour cells (CTCs) as biomarkers of resistance to the CDK4/6 inhibitor (CDK4/6i) palbociclib (P) in patients (pts) with ER+/HER2-negative advanced breast cancer (ABC)
Authors: F. Galardi, C. Biagioni, F. De Luca, G. Curigliano, A.M. Minisini, M. Bonechi, E. Moretti, E. Risi, I. Migliaccio, A. McCartney, M. Benelli, D. Romagnoli, V. Conti, L. Biganzoli, A. Di Leo, L. Malorni
Journal: Annals of Oncology (2020)
Somatic Symptom Disorder and the Physician’s Role
Authors: Claire R. Galvin, Astrid M. De Souza, Kathryn R. Armstrong
Journal: JAMA Pediatrics (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
A single-cell approach to engineer CD8+ T cells targeting cytomegalovirus
Authors: Fei Wang, Qumiao Xu, Zhenkun Zhuang, Ziyi Li, Qianqian Gao, Yaling Huang, Yonglun Luo, Xiuqing Zhang, Linnan Zhu, Cheng-chi Chao
Journal: Cellular and Molecular Immunology (2020)
Accuracy of Two-Dimensional Shear Wave Elastography and Attenuation Imaging for Evaluation of Patients With Nonalcoholic Steatohepatitis
Authors: Dong Ho Lee, Eun Ju Cho, Jae Seok Bae, Jae Young Lee, Su Jong Yu, Haeryoung Kim, Kyung Bun Lee, Joon Koo Han, Byung Ihn Choi
Journal: Clinical Gastroenterology and Hepatology (2020)
Clinical decision making: from theory to practice. The individual vs society. Resolving the conflict
Authors: D M Eddy
Journal: JAMA (1991)

AN INDIVIDUAL can be in conflict with society whenever the individual uses a disproportionate amount of a health care service without paying for it.<sup>1</sup>This either forces others to cover the cost of replacing the service or, if the cost is not repaid and the service is not replaced, deprives others of the benefits of the service. The first causes others financial harm. The second causes harm to their health. In either case, the "others" are what we call "society." If the individual is incapable of paying, and if the service is considered essential,<sup>2</sup>then the use of such a service is considered acceptable; it is viewed as part of society's obligation to individuals in need. However, as the individual's ability to pay increases, as the benefit provided by the service decreases, and as the cost of the service increases, the conflict grows. <h3>The Source of the Conflict</h3>
Obstetrics in General Practice: Antenatal Care--2
Authors: C. J. Dewhurst
Journal: BMJ (1964)

The previous article on antenatal care surveyed the problem in general and dealt in detail with the patient's first visit.At this visit the diagnosis of pregnancy, selection of the most appro- priate place for the confinement, and the general advice to be given-to the patient were all discussed.In this article we shall consider antenatal care under the second and third headingsvisits up to 32 weeks, and the last two months of pregnancy.Visits up to 32 Weeks As I mentioned in the first article, it is customary for a patient to be asked to attend monthly until the 28th week, fortnightly until the 36th week, and weekly thereafter until she is delivered.In cases in which there is no specific abnormality we will chiefly be concerned during this time with the prevention of toxaemia of pregnancy and anaemia as well as with any problems the patient may have.Toxaemia of pregnancy is the principal cause of maternal death at present.The second most common cause is haemor- rhage, which is always more serious in the anaemic patient.
Beyond the Bench: Keeping Migrant Families Safe
Authors: Kimberly G. Thigpen
Journal: Environmental Health Perspectives (2004)

For the thousands of migrant farmworkers who come to the United States in search of jobs, this country may seem like the land of opportunity. For their children, however, it also offers the opportunity for serious injury or even death from exposure to household toxicants that parents may not be aware of or have the language ability to recognize as a hazard. A program of the Community Outreach and Education Program at the University of California, Davis, Center for Environmental Health Sciences is seeking to provide migrant families in Northern California with the skills to protect their children from accidental poisonings.

The Safety Literacy for Migrant Farm Worker Families: Childhood Poison Prevention project uses a variety of means to reach and educate migrant families. The centerpiece of the program is training conducted in Spanish at migrant housing centers, in which parents and staff are taught how to read and interpret safety warnings and emergency first aid instructions. These classes cover basic safety information on over-the-counter medicines and vitamins, household and personal care products (such as bleach, cleansers, and bug sprays), plants and other environmental toxicants, and pesticides used in the home or at work. Participants are also taught how to read labels, what to do in case of poisoning, and how to use 9-1-1 and poison control centers. Participants receive a variety of printed safety resources in Spanish such as booklets, posters, and stickers, and each trainee is given four safety latches to secure chemicals stored in their homes.

To date, classes have been provided at five Head Start/Early Head Start child development centers in Yolo County, and at a series of parenting sessions organized by Yolo Connections, an umbrella agency whose mission is to promote volunteerism, mentoring, and community partnership. The poison prevention training has also been presented at the annual California Office of Migrant Services conference to 83 staff members representing all 26 migrant housing centers in California.

Center staff have also developed safety materials for posting and distribution in target camps that illustrate the proper use and storage of toxic household substances, as well as emergency first aid techniques. The materials are distributed to Head Start, parenting classes, and migrant camps through collaboration with the California Poison Control Center, the California Office of Migrant Services, and the nonprofit California Human Development Corporation.

The Safety Literacy for Migrant Farm Worker Families program goes beyond education to preventive action through the distribution and installation of child-proof locks in migrant housing. By the 2004 harvest season, more than 1,000 safety latches will have been purchased by the project and installed in migrant camps throughout Yolo County. More information on the project can be found at the center’s website at http://www.envtox.ucdavis.edu/cehs/.
Letter: Acute carbamazepine encephalopathy
Authors: M. Salcman
Journal: JAMA (1975)

<h3>To the Editor.—</h3> We are presenting a case of encephalopathy secondary to a massive overdose of carbamazepine (Tegretol). The clinical picture is nonspecific and may be confused with the postictal state in those patients who have access to this anticonvulsant. <h3>Report of a Case.—</h3> A 16-year-old boy was brought to the Neurological Institute after having failed to recover from a presumed psychomotor seizure. The patient had suffered three previous episodes in the preceding year and therapy had recently been started with carbamazepine, 200 mg twice daily. On admission, the patient was seen in profound stupor. He neither responded to speech nor made spontaneous vocalizations. Minimal painful stimuli would elicit semipurposeful movements of the extremities. Strength, tone, and deep tendon reflexes appeared to be unimpaired. Examination of the cranial nerves showed normal fundi, brisk corneal reflexes, and normal pupillary responses. Nevertheless, biplanar disconjugate gaze (skew deviation) and an absent response to
Human and mouse studies establish TBX6 in Mendelian CAKUT and as a potential driver of kidney defects associated with the 16p11.2 microdeletion syndrome
Authors: Nan Yang, Nan Wu, Shuangshuang Dong, Ling Zhang, Yanxue Zhao, Weisheng Chen, Renqian Du, Chengcheng Song, Xiaojun Ren, Jiaqi Liu, Davut Pehlivan, Zhenlei Liu, Jia Rao, Chunyan Wang, Sen Zhao, Amy M. Breman, Huadan Xue, Hao Sun, Jianxiong Shen, Shuyang Zhang, Jennifer E. Posey, Hong Xu, Li Jin, Jianguo Zhang, Pengfei Liu, Simone Sanna-Cherchi, Guixing Qiu, Zhihong Wu, James R. Lupski, Feng Zhang
Journal: Kidney International (2020)
Avoiding health worker infection and containing the coronavirus disease 2019 pandemic: Perspectives from the frontline in Wuhan
Authors: Ling-hua Tang, Shan Tang, Xiao-liang Chen, Shi Zhang, Yong Xiong, Rong Chen, Wei Li, Hui-min Liu, Zhong-yuan Xia, Qing-tao Meng
Journal: International Journal of Surgery (2020)
Long-term outcome of a randomised controlled trial comparing tacrolimus with mycophenolate mofetil as induction therapy for active lupus nephritis
Authors: Chi Chiu Mok, Ling Yin Ho, Shirley King Yee Ying, Man Chi Leung, Chi Hung To, Woon Leung Ng
Journal: Annals of the Rheumatic Diseases (2020)

To report the 10-year outcome of lupus nephritis (LN) treated with mycophenolate mofetil (MMF) or tacrolimus (TAC) induction in a randomised controlled trial.Patients with active LN were treated with MMF or TAC combined with high-dose prednisolone. Responders were switched to azathioprine (AZA) at month 6. Clinical outcomes at 10 years (renal flares, renal function decline and mortality) were assessed. Factors affecting prognosis were studied by Cox regression. Urine protein-to-creatinine ratio (uPCr) and estimated glomerular filtration rate (eGFR) at different time points were evaluated for their prediction of a poor prognosis by receiver operating characteristic (ROC) analysis.150 patients were studied (age 35.5±12.8 years). Complete renal response rate was similar between MMF (59%) and TAC-treated patients (62%; p=0.71). AZA maintenance was given to 79% patients. After 118.2±42 months, proteinuric and nephritic renal ﬂares occurred in 34% and 37% of the MMF, and 53% and 30% of the TAC groups of patients, respectively (p=0.49). The cumulative incidence of a composite outcome of ↓eGFR ≥30%, chronic kidney disease stage 4/5 or death at 10 years was 33% in both groups (p=0.90). Factors independently associated with a poor renal prognosis were first-time LN (HR 0.12 (0.031 to 0.39); p=0.01), eGFR (HR 0.98 (0.96 to 0.99); p=0.008) and no response at month 6 (HR 5.18 (1.40 to 19.1); p=0.01). ROC analysis revealed an uPCr >0.75 and eGFR of <80 mL/min at month 18 best predicted a poor renal prognosis.Long-term data confirmed non-inferiority of TAC to MMF as induction therapy of LN. An uPCr≤0.75 and eGFR of ≥80 mL/min at month 18 best predicted a favourable 10-year outcome and may be suitable targets for induction/consolidation therapy.NCT00371319.
Denise Coia: mental health champion and chair of the Royal College of Psychiatrists in Scotland
Authors: Penny Warren
Journal: BMJ (2020)

Credit: Healthcare Improvement Scotland

In 1987 Denise Coia became a consultant clinical psychiatrist in the deprived Gorbals area of south Glasgow. Passionate about mental health, she was determined to transform its Cinderella status and put it on the same footing as cancer or orthopaedic surgery. She spent the next 30 years working in Glasgow and spearheaded numerous initiatives to raise standards in Scotland and beyond. The chair of the Royal College of Psychiatrists in Scotland, John Crichton, said, “Denise’s extraordinary contribution to psychiatry, as well as to the wider medical profession, can only be described as unmatched.”

A much loved only child, Coia was born in 1952 and brought up in Milngavie on the outskirts of Glasgow. Her father, Joe, and her glamorous mother, Jill, were of Italian and Welsh descent, respectively, and ran the local fish and chip restaurant, where Coia would sometimes take schoolfriends back for tea. She went to Notre Dame School for Girls, where she enjoyed singing and tennis, and, rather to the surprise of some, opted to study medicine.

Coia attended the …
Mitigating the psychological effects of social isolation during the covid-19 pandemic
Authors: Mohammad S Razai, Pippa Oakeshott, Hadyn Kankam, Sandro Galea, Helen Stokes-Lampard
Journal: BMJ (2020)

What you need to know• Primary care could provide unique relationship-based continuity of care to patients with psychological effects from social isolation during the current covid-19 pandemic• Such patients could be identified with existing simple and validated screening tools PRACTICE
Resolution of NASH and hepatic fibrosis by the GLP-1R and GCGR dual-agonist cotadutide via modulating mitochondrial function and lipogenesis
Authors: Michelle L. Boland, Rhianna C. Laker, Karly Mather, Arkadiusz Nawrocki, Stephanie Oldham, Brandon B. Boland, Hilary Lewis, James Conway, Jacqueline Naylor, Silvia Guionaud, Michael Feigh, Sanne S. Veidal, Louise Lantier, Owen P. McGuinness, Joseph Grimsby, Cristina M. Rondinone, Lutz Jermutus, Martin R. Larsen, James L. Trevaskis, Christopher J. Rhodes
Journal: Nature Metabolism (2020)
Peritoneal Carcinomatosis of Unknown Primary Site in Women
Authors: Charles M. Strnad, William W. Grosh, Jere Baxter, Lonnie S. Burnett, Howard W. Jones, F. Anthony Greco, John D. Hainsworth
Journal: Annals of Internal Medicine (2020)

Abstract Study Objective:To define the clinical features and results of systemic treatment in women with adenocarcinoma of unknown primary site involving predominantly the peritoneal surfaces. Desi...