tbuckley/cabot-search huggingface dataset:
Role of Postintervention Fractional Flow Reserve to Improve Procedural and Clinical Outcomes
Authors: Abdul Hakeem, Barry F. Uretsky
Journal: Circulation (2019)

The value of fractional flow reserve (FFR) in determining the appropriateness of percutaneous coronary intervention (PCI) has been well established and incorporated into current guidelines and appropriate use criteria. However, the value of performing FFR after intervention is uncertain. This review provides the current evidence base highlighting the clinical and prognostic implications of post-PCI FFR. It provides evidence for improvement in post-PCI FFR with subsequent interventions (functional optimization) challenging the notion that FFR after angiographic optimization is fixed because of the underlying plaque burden. Multiple large observational studies and post hoc analyses of randomized trials have established that post-PCI FFR value is independently predictive of long-term outcomes (higher is better). The accumulated evidence suggests that post-PCI FFR be incorporated into routine practice in those patients having undergone pre-PCI FFR as part of clinical decision making.
Sally Davies steps down as England’s chief medical officer
Authors: Abi Rimmer
Journal: BMJ (2019)

England’s first female chief medical officer (CMO) is moving on to become the first female master of Trinity College, at the University of Cambridge, in the autumn.

Sally Davies was appointed CMO for England and chief medical advisor to the UK government in March 2011, after having held the post on an interim basis since June 2010.

Before her appointment, Davies worked as an NHS consultant haematologist for 30 years and was the first UK medical practitioner to specialise in sickle cell …
What motivates devoted actors to extreme sacrifice, identity fusion, or sacred values?
Authors: Scott Atran, Ángel Gómez
Journal: Behavioral and Brain Sciences (2018)

Abstract Why do some individuals willingly make extreme sacrifices for their group? Whitehouse argues that such willingness stems from a visceral feeling of oneness with the group – identity fusion – that emerges from intense, shared dysphoric experiences or from perceived close kinship with others. Although Whitehouse's argument makes a valuable contribution to understanding extreme sacrifice, factors independent of identity fusion, such as devotion to sacred values, can predict self-sacrifice.
Kinase Inhibitors (ibrutinib or idelalisib) in the Management of Chronic Lymphocytic Leukemia-Associated Autoimmune Cytopenia: A Retrospective Study of the French Innovative Leukemia Organization (FILO)
Authors: Sophie Godet, Anne Quinquenel, Caroline Dartigeas, Loic Ysebaert, Jehan Dupuis, Haykanush Ohanyan, Aude Collignon, Laurent Gilardin, Stéphane Leprêtre, Marie-Sarah Dilhuydy, Marguerite Vignon, Sophie de Guibert, Natalia Dmytruk, Eric Durot, David Ghez, Damien Roos-Weil, Elise Toussaint, Fatiha Merabet, Vincent Levy, Alain Jacques Delmer, Thérèse Aurran
Journal: Blood (2018)
Abstract 17425: Different Effect of Percutaneous Edge-to-Edge Repair on Mitral Valve Geometry Between Central and Eccentric Functional Mitral Regurgitation
Authors: Hiroto Utsunomiya, Yuji Itabashi, Sayuki Kobayashi, Takafumi Nagaura, Satoshi Yamaguchi, Takayuki Hidaka, Yasuki Kihara, Sibal Kar, Takahiro Shiota
Journal: Circulation (2017)

Background: An eccentric jet can be seen in functional mitral regurgitation (FMR) when there is an asymmetric tethering with a pseudoprolapse of the anterior leaflet. Effects of percutaneous edge-t...
Evaluating the Properties of a Frailty Index and Its Association With Mortality Risk Among Patients With Systemic Lupus Erythematosus
Authors: Alexandra Legge, Susan Kirkland, Kenneth Rockwood, Pantelis Andreou, Sang‐Cheol Bae, Caroline Gordon, Juanita Romero‐Diaz, Jorge Sanchez‐Guerrero, Daniel J. Wallace, Sasha Bernatsky, Ann E. Clarke, Joan T. Merrill, Ellen M. Ginzler, Paul Fortin, Dafna D. Gladman, Murray B. Urowitz, Ian N. Bruce, David A. Isenberg, Anisur Rahman, Graciela S. Alarcón, Michelle Petri, Munther A. Khamashta, M. A. Dooley, Rosalind Ramsey‐Goldman, Susan Manzi, Kristjan Steinsson, Asad A. Zoma, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz‐Irastorza, S. Sam Lim, Murat Inanc, Ronald F. van Vollenhoven, Andreas Jonsen, Ola Nived, Manuel Ramos‐Casals, Diane L. Kamen, Kenneth C. Kalunian, Soren Jacobsen, Christine A. Peschken, Anca Askanase, John G. Hanly
Journal: Arthritis & Rheumatology (2019)

To evaluate the properties of a frailty index (FI), constructed using data from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort, as a novel health measure in systemic lupus erythematosus (SLE).For this secondary analysis, the baseline visit was defined as the first study visit at which both organ damage (SLICC/American College of Rheumatology Damage Index [SDI]) and health-related quality of life (Short-Form 36 [SF-36] scores) were assessed. The SLICC-FI was constructed using baseline data. The SLICC-FI comprises 48 health deficits, including items related to organ damage, disease activity, comorbidities, and functional status. Content, construct, and criterion validity of the SLICC-FI were assessed. Multivariable Cox regression was used to estimate the association between baseline SLICC-FI values and mortality risk, adjusting for demographic and clinical factors.In the baseline data set of 1,683 patients with SLE, 89% were female, the mean ± SD age was 35.7 ± 13.4 years, and the mean ± SD disease duration was 18.8 ± 15.7 months. At baseline, the mean ± SD SLICC-FI score was 0.17 ± 0.08 (range 0-0.51). Baseline SLICC-FI values exhibited the expected measurement properties and were weakly correlated with baseline SDI scores (r = 0.26, P < 0.0001). Higher baseline SLICC-FI values (per 0.05 increment) were associated with increased mortality risk (hazard ratio 1.59, 95% confidence interval 1.35-1.87), after adjusting for age, sex, steroid use, ethnicity/region, and baseline SDI scores.The SLICC-FI demonstrates internal validity as a health measure in SLE and might be used to predict future mortality risk. The SLICC-FI is potentially valuable for quantifying vulnerability among patients with SLE, and adds to existing prognostic scores.
Tepid Steps on Drug Pricing
Authors: Ameet Sarpatwari, Aaron S. Kesselheim
Journal: JAMA Internal Medicine (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Pulmonary nodules in a patient with Giant Cell Arteritis
Authors: D. Pinho dos Santos, J.P. Fonseca, V. Romão, J. Capelo, A. Carragoso
Journal: Pulmonology (2019)

Giant Cell Arteritis (GCA) is a common systemic vasculitis that involves medium and large arteries, most frequently extracranial branches of the carotid artery. Prompt diagnosis and treatment is essential to prevent devastating complications, such as blindness, stroke and aortic aneurysm or dissection. Typical symptoms include headache, temporal artery tenderness and jaw claudication. On rare occasions patients present with complaints related to pulmonary involvement. These include interstitial infiltration, pulmonary nodules, pleural effusion and pulmonary haemorrhage. The authors report the case of a 74-year-old man who presented with symptoms compatible with GCA confirmed by temporal biopsy, and pulmonary nodules. These lesions were biopsied and histological exam confirmed features compatible with systemic vasculitis. The lesions resolved after two months of steroid treatment. This case shows that we should be aware of atypical GCA manifestations.
Anti-epidermal growth factor receptor (EGFR) monoclonal antibody combined with cisplatin and 5-fluorouracil in patients with metastatic nasopharyngeal carcinoma after radical radiotherapy: a multicentre, open-label, phase II clinical trial
Authors: C. Zhao, J. Miao, G. Shen, J. Li, M. Shi, N. Zhang, G. Hu, X. Chen, X. Hu, S. Wu, J. Chen, X. Shao, L. Wang, F. Han, H. Mai, M.L.K. Chua, C. Xie
Journal: Annals of Oncology (2019)

We conducted a single-arm phase II trial to evaluate the efficacy and adverse effects (AEs) of an anti-epidermal growth factor receptor monoclonal antibody, nimotuzumab, combined with cisplatin and 5-fluorouracil (PF) as first-line treatment in recurrent metastatic nasopharyngeal carcinoma after radical radiotherapy.
The Mutational Landscape of Primary Plasma Cell Leukemia
Authors: Carolina D. Schinke, Cody Ashby, Yan Wang, Ruslana G. Tytarenko, Eileen Boyle, Christopher Wardell, Pingping Qu, Sharmilan Thanendrarajan, Sandra Susanibar, Naveen Yarlagadda, Maliha Khan, Meera Mohan, Maurizio Zangari, Frits van Rhee, Faith E. Davies, Bart Barlogie, Gareth Morgan, Brian A Walker
Journal: Blood (2018)
Epigenetic age acceleration is associated with allergy and asthma in children in Project Viva
Authors: Cheng Peng, Andres Cardenas, Sheryl L. Rifas-Shiman, Marie-France Hivert, Diane R. Gold, Thomas A. Platts-Mills, Xihong Lin, Emily Oken, Lydiana Avila, Juan C. Celedón, Scott T. Weiss, Andrea A. Baccarelli, Augusto A. Litonjua, Dawn L. DeMeo
Journal: Journal of Allergy and Clinical Immunology (2019)
Abstract 19892: Presepsin, Soluble CD14 Subtype, is a Novel Marker of Six-Month Mortality in Patients Hospitalized to Coronary Care Units
Authors: Hideto Nishimura, Junnichi Ishii, Hiroshi Takahashi, Hideki Kawai, Takashi Muramatsu, Masahide Harada, Sadako Motoyama, Shigeru Matsui, Hiroyuki Naruse, Eiichi Watanabe, Mutsuharu Hayashi, Hideo Izawa, Yukio Ozaki
Journal: Circulation (2017)

Background: Presepsin, a subtype of soluble CD14, is an inflammatory marker, which largely reflects monocyte activation. Presepsin appears to be an accurate diagnostic marker of sepsis, but its cli...
Diagnosis Of Cephalosporin Allergy Through Graded Oral Challenge
Authors: Zahia Attari, Sofianne Gabrielli, Bahar Torabi, Christine Lejtenyi, Andrew O’Keefe, Adelle R. Atkinson, Vy Hong-Diep Kim, Thomas Eiwegger, Yarden Yanishevsky, Christine T. McCusker, Moshe Ben-Shoshan
Journal: Journal of Allergy and Clinical Immunology (2019)
Defining DNA damage repair deficiency and replication stress in pancreatic cancer.
Authors: Stephan Dreyer, Viola Paulus-Hock, Rosie Upstill-Goddard, Eirini Lampraki, Nigel Jamieson, Susie Cooke, Peter Bailey, Andrew Biankin, David Kuang-Fu Chang
Journal: Journal of Clinical Oncology (2019)

285 Background: Integrated multi-omic analyses revealed 24% of pancreatic cancer (PC) harbor defects in DNA damage response (DDR) and a subgroup demonstrate upregulation in replication stress pathways. DDR defective tumors preferentially respond to DNA damaging agents, and clinical responses to cell cycle inhibitors are seen in undefined subgroups, representing novel therapeutic strategies for PC. The aim of this study is to define and refine therapeutic segments for agents targeting DDR and replication stress in PC. Methods: We performed whole genome and RNA sequencing (RNAseq) on 48 patient-derived cell lines (PDCL) generated and characterized as part of the International Cancer Genome Initiative (ICGC). This identified increased replication stress in a sub-group of tumours, correlating with previously defined molecular subtypes of PC, irrespective of DDR status. Cytotoxic viability assays were performed using agents targeting the DDR pathway and cell cycle checkpoints, including Cisplatin, and inhibitors of PARP, ATR, WEE1, CHK1, CDK4/6 and PLK4. Subcutaneous patient derived xenografts (PDX) were generated to test therapeutic regimens in vivo. Results: DDR defective models, as defined by signatures of homologous recombination deficiency (HRD) were highly sensitive to Cisplatin and PARP inhibitors. Replication stress predicted differential responses to cell cycle inhibitors of WEE1, CHK1, CDK4/6 and PLK4. A novel mRNA signature of ATR inhibitor sensitivity was generated and correlated with response. Response to cell cycle checkpoint inhibitors were independent of DDR status, but strongly associated with replication stress. Conclusions: This proof of concept data demonstrates DDR deficiency and increased Replication Stress to be attractive targets in PC. Therapeutic vulnerabilities extend beyond platinum chemotherapy and can be targeted with novel small molecule inhibitors, with independent biomarkers predicting response to agents targeting either DDR or cell cycle checkpoints. This has led to the design and development of several personalized medicine trials via the Precision Panc platform targeting DDR and Replication stress, and will allow clinical testing of signatures of HRD and replication stress.
QUALITY OF LIFE IN SPANISH CHILDREN WITH ALLERGY TO MULTIPLE FOODS USING A SPANISH VERSION OF THE FOOD ALLERGY QUALITY OF LIFE QUESTIONNAIRE-PARENT FORM (S-FAQLQ-PF)
Authors: Monica Rodriguez-Alvarez, Sabela Perez-Codesido, Martina Privitera Torres, Madel Mar Moro Moro, Elia Perez Fernandez, Ma Dolores Alonso Diaz de Durana
Journal: Journal of Allergy and Clinical Immunology (2019)
Abstract 17159: Targeting Factor XII (F12) With a Novel RNAi Delivery Platform as a Prophylactic Treatment for Thromboembolism
Authors: Stacey Melquist, Darren Wakefield, Holly Hamilton, Qili Chu, Aaron Almeida, Lauren Almeida, Christine Chapman, Jessica Montez, Jason Klein, Julia Hegge, Molly Zeller, Megan Walters, Aaron Andersen, Tracie Milarch, Edie Doss, David Rozema, David Lewis, Steven Kanner
Journal: Circulation (2016)

Introduction: Current anticoagulants effectively prevent thromboembolic (TBE) events, but unmet need remains due to an elevated risk of major bleeding events. Factor XII (F12) autoactivation initia...
Distinct Immune Cell Populations Define Response to Anti-PD-1 Monotherapy and Anti-PD-1/Anti-CTLA-4 Combined Therapy
Authors: Tuba N. Gide, Camelia Quek, Alexander M. Menzies, Annie T. Tasker, Ping Shang, Jeff Holst, Jason Madore, Su Yin Lim, Rebecca Velickovic, Matthew Wongchenko, Yibing Yan, Serigne Lo, Matteo S. Carlino, Alexander Guminski, Robyn P.M. Saw, Angel Pang, Helen M. McGuire, Umaimainthan Palendira, John F. Thompson, Helen Rizos, Ines Pires da Silva, Marcel Batten, Richard A. Scolyer, Georgina V. Long, James S. Wilmott
Journal: Cancer Cell (2019)

Highlights•Activated T cell signatures/populations drive response to anti-PD-1-based therapies•EOMES+CD69+CD45RO+ effector memory T cells are associated with response•EOMES+CD69+CD45RO+ expression is associated with longer PFS and tumor shrinkage•Non-responders with TIL-hot tumors express other immune drug targetsSummaryCancer immunotherapies provide survival benefits in responding patients, but many patients fail to respond. Identifying the biology of treatment response and resistance are a priority to optimize drug selection and improve patient outcomes. We performed transcriptomic and immune profiling on 158 tumor biopsies from melanoma patients treated with anti-PD-1 monotherapy (n = 63) or combined anti-PD-1 and anti-CTLA-4 (n = 57). These data identified activated T cell signatures and T cell populations in responders to both treatments. Further mass cytometry analysis identified an EOMES+CD69+CD45RO+ effector memory T cell phenotype that was significantly more abundant in responders to combined immunotherapy compared with non-responders (n = 18). The gene expression profile of this population was associated with longer progression-free survival in patients treated with single agent and greater tumor shrinkage in both treatments.Graphical Abstract
Combined liver and hematopoietic stem cell transplantation in patients with X-linked hyper-IgM syndrome
Authors: Giorgia Bucciol, Sarah K. Nicholas, Pier Luigi Calvo, Andrew Cant, J. David M. Edgar, Teresa Español, Francesca Ferrua, Miguel Galicchio, Andrew R. Gennery, Nedim Hadzic, I. Celine Hanson, Gustavo Kusminsky, Andrzej Lange, Fanny Lanternier, Nizar Mahlaoui, Despina Moshous, Zohreh Nademi, Benedicte Neven, Matias Oleastro, Fulvio Porta, Paola Quarello, Marcelo Silva, Mary A. Slatter, Elena Soncini, Marek Stefanowicz, Francesco Tandoi, Mikołaj Teisseyre, Troy R. Torgerson, Paul Veys, Katja G. Weinacht, Beata Wolska-Kuśnierz, Jacques Pirenne, M. Teresa de la Morena, Isabelle Meyts
Journal: Journal of Allergy and Clinical Immunology (2019)
The Engineered MIPI (e-MIPI), a Candidate Data-Mining Based Mantle Cell Lymphoma Prognostic Index Developed from the Dataset of the Fondazione Italiana Linfomi (FIL) MCL0208 Phase III Trial
Authors: Gian Maria Zaccaria, Simone Ferrero, Roberto Passera, Andrea Evangelista, Mariella Loschirico, Irene Dogliotti, Marco Ghislieri, Elisa Genuardi, Riccardo Bomben, Valter Gattei, Giovannino Ciccone, Monica Tani, Gianluca Gaidano, Stefano Volpetti, Maria Giuseppina Cabras, Nicola Di Renzo, Francesco Merli, Daniele Vallisa, Michele Spina, Anna Pascarella, Giancarlo Latte, Caterina Patti, Gabriele Pozzato, Alberto Fabbri, Sergio Cortelazzo, Marco Ladetto
Journal: Blood (2018)
Cytokine profiles in patients with Q fever fatigue syndrome
Authors: Ruud P.H. Raijmakers, Valerie A.C.M. Koeken, Anne F.M. Jansen, Stephan P. Keijmel, Megan E. Roerink, Leo A.B. Joosten, Mihai G. Netea, Jos W.M. van der Meer, Chantal P. Bleeker-Rovers
Journal: Journal of Infection (2019)
The Human Brain Project: Responsible Brain Research for the Benefit of Society
Authors: Arleen Salles, Jan G. Bjaalie, Kathinka Evers, Michele Farisco, B. Tyr Fothergill, Manuel Guerrero, Hannah Maslen, Jeffrey Muller, Tony Prescott, Bernd C. Stahl, Henrik Walter, Karl Zilles, Katrin Amunts
Journal: Neuron (2019)
2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation
Authors: Craig T. January, L. Samuel Wann, Hugh Calkins, Lin Y. Chen, Joaquin E. Cigarroa, Joseph C. Cleveland, Patrick T. Ellinor, Michael D. Ezekowitz, Michael E. Field, Karen L. Furie, Paul A. Heidenreich, Katherine T. Murray, Julie B. Shea, Cynthia M. Tracy, Clyde W. Yancy
Journal: Journal of the American College of Cardiology (2019)
Abstract 11940: Aortic Complications Associated With Pregnancy in Marfan Syndrome: The NHLBI GenTAC Registry
Authors: Mary J Roman, Ryan E Whitworth, Joseph E Bavaria, Richard B Devereux, Hal Dietz, Kathryn Holmes, Kim A Eagle, Scott A LeMaire, Shaine A Morris, Reed Pyeritz, William J Ravekes, Michael Silberbach
Journal: Circulation (2015)

Background: Definition of pregnancy risk in women with Marfan syndrome (MFS) has been confounded by ascertainment bias, lack of imaging data, small sample size, and inclusion of women without a known MFS diagnosis before a pregnancy complication. To lessen these limitations, we analyzed MFS women participating in the large GenTAC Registry. Results: Among 184 women in whom pregnancy information was available, 94 women (51%) had a total of 227 pregnancies (average 2.5, range 1-6). Compared to MFS women who never became pregnant, those with pregnancies were older at time of MFS diagnosis (27 vs. 13 years, p&lt;0.0001) and at time of GenTAC enrollment (47 vs. 37 years, p&lt;0.0001). When comparing ever-pregnant to never-pregnant women with MFS at the time of registry entry, higher historical rates of aortic dissection and prophylactic proximal aortic surgery were observed (24/94 [25.5%] vs. 13/90 [14.4%], p=0.068 and 15/94 [16.0%] vs. 4/90 [4.4%], p=0.014; respectively). Among the 94 MFS women with pregnancies, 10 (10.6%) experienced a pregnancy-related aortic complication (4 Type A and 3 Type B dissections, one coronary artery dissection, and 2 with significant [≥3 mm] aortic growth, 1 of whom required post-partum prophylactic surgery). Four of the aortic dissections, including all 3 Type B, and the coronary dissection occurred in the post-partum period. Only 3 of 7 women (43%) with an aortic dissection related to pregnancy were aware of their MFS diagnosis before pregnancy. Women with and without pregnancy-associated aortic complications did not differ in phenotypic features. The rate of aortic dissection was higher during pregnancy + post-partum period (3.5 per 100 person-years vs. 0.8 per 100 person-years, odds ratio 4.6 [95% confidence interval 2.1-10.1], p=0.0002). Conclusions: Pregnancy in MFS is associated with an increased risk of aortic dissection, both Types A and B, particularly in the immediate post-partum period, and more frequent prophylactic surgery. Lack of knowledge of underlying MFS diagnosis before aortic dissection is a major contributing factor. These findings underscore the need for early diagnosis, pre-pregnancy risk counselling, and multi-disciplinary peri-partum management.