tbuckley/cabot-search huggingface dataset:
Controlling nutritional status (CONUT) score is a prognostic factor in patients with resected breast cancer
Authors: W. Li, Y. Deng, G. Ma, Q. Wu, Q. Zhou
Journal: Annals of Oncology (2019)

Background: Controlling nutritional status (CONUT), as an index to measure a patient's nutritional condition, was found to be correlated with outcomes of various cancers. However, its prognostic role in breast cancer patients with curative resection remains unclear. Hence the present study was designed to determine the correlation between CONUT and prognosis in resected breast cancer patients. Methods: A total of 861 breast cancer patients with surgical resection in West China Hospital of Sichuan University between 2007 and 2010 were included in the present study. CONUT was retrospectively evaluated for each patient, and its relationship with various clinicopathological factors and breast cancer prognosis were further evaluated. Results: When the receiver operating characteristic (ROC) curve analysis was performed, CONUT had a higher area under the ROC curve (AUC) for the prediction of 5-year disease free survival (DFS) and overall survival (OS) compared with the neutrophil lymphocyte ratio (NLR) and prognostic nutritional index (PNI). Besids, the optimal cutoff value for CONUT to predict the 5-year survival was 3. Moreover, high CONUT was significantly correlated with older age, lymph node involvement, advanced T-stage and surgery type. In the multivariate analysis, CONUT-high patients had significantly poorer DFS and OS, when compared with CONUT-low patients. In the subgroup analysis, high CONUT was still an independent prognostic factor for poor DFS and OS for all stages of breast cancer. In addition, these results continued to maintain its significance in the multivariable analysis for patients with luminal B tumors. Conclusions: The preoperative CONUT is a simple and uesful marker for predicting long term outcomes in breast cancer patients after curative resection. Legal entity responsible for the study: Qinghua Zhou. Funding: Has not received any funding. Disclosure: All authors have declared no conflicts of interest.
EUS-DIRECTED TRANSGASTRIC ERCP IN A BILLROTH II GASTRECTOMY BY USING LUMEN-APPOSING METAL STENT
Authors: B Martínez, JA Casellas, JR Aparicio
Journal: Endoscopy (2019)

In Billroth II anatomy, ERCP is challenging. Intubation of the afferent limb is sometime imposible due to an acute angle or long afferent limb.
Abstract 14697: Ventricular Conduction and Long-term Outcomes in African Americans: Insights from the Jackson Heart Study
Authors: Robert J Mentz, Melissa A Greiner, Adam D DeVore, Shannon M Dunlay, Gaurav Choudhary, Prateeti Khazanie, Tariq Ahmad, Tiffany Randolph, Zubin J Eapen, Emily C O’Brien, Kevin L Thomas, Lesley H Curtis, Adrian F Hernandez
Journal: Circulation (2014)

Background: Prolonged QRS duration has been associated with adverse outcomes in mostly white populations, but its clinical significance is not well established in other races. Hypothesis: QRS prolo...
A modular transcriptome map of mature B cell lymphomas
Authors: Henry Loeffler-Wirth, Markus Kreuz, Lydia Hopp, Arsen Arakelyan, Andrea Haake, Sergio B Cogliatti, Alfred C Feller, Martin-Leo Hansmann, Dido Lenze, Peter Möller, Hans Konrad Müller-Hermelink, Erik Fortenbacher, Edith Willscher, German Ott, Andreas Rosenwald, Christiane Pott, Carsten Schwaenen, Heiko Trautmann, Swen Wessendorf, Harald Stein, Monika Szczepanowski, Lorenz Trümper, Michael Hummel, Wolfram Klapper, Reiner Siebert, Markus Loeffler, Hans Binder
Journal: Genome Medicine (2019)

Germinal center-derived B cell lymphomas are tumors of the lymphoid tissues representing one of the most heterogeneous malignancies. Here we characterize the variety of transcriptomic phenotypes of this disease based on 873 biopsy specimens collected in the German Cancer Aid MMML (Molecular Mechanisms in Malignant Lymphoma) consortium. They include diffuse large B cell lymphoma (DLBCL), follicular lymphoma (FL), Burkitt's lymphoma, mixed FL/DLBCL lymphomas, primary mediastinal large B cell lymphoma, multiple myeloma, IRF4-rearranged large cell lymphoma, MYC-negative Burkitt-like lymphoma with chr. 11q aberration and mantle cell lymphoma. We apply self-organizing map (SOM) machine learning to microarray-derived expression data to generate a holistic view on the transcriptome landscape of lymphomas, to describe the multidimensional nature of gene regulation and to pursue a modular view on co-expression. Expression data were complemented by pathological, genetic and clinical characteristics. We present a transcriptome map of B cell lymphomas that allows visual comparison between the SOM portraits of different lymphoma strata and individual cases. It decomposes into one dozen modules of co-expressed genes related to different functional categories, to genetic defects and to the pathogenesis of lymphomas. On a molecular level, this disease rather forms a continuum of expression states than clearly separated phenotypes. We introduced the concept of combinatorial pattern types (PATs) that stratifies the lymphomas into nine PAT groups and, on a coarser level, into five prominent cancer hallmark types with proliferation, inflammation and stroma signatures. Inflammation signatures in combination with healthy B cell and tonsil characteristics associate with better overall survival rates, while proliferation in combination with inflammation and plasma cell characteristics worsens it. A phenotypic similarity tree is presented that reveals possible progression paths along the transcriptional dimensions. Our analysis provided a novel look on the transition range between FL and DLBCL, on DLBCL with poor prognosis showing expression patterns resembling that of Burkitt's lymphoma and particularly on 'double-hit' MYC and BCL2 transformed lymphomas. The transcriptome map provides a tool that aggregates, refines and visualizes the data collected in the MMML study and interprets them in the light of previous knowledge to provide orientation and support in current and future studies on lymphomas and on other cancer entities.
Errors in Exclusion of Data and Reported Trends of Prescriptions in Study of Opioid Prescriptions Dispensed to Children and Adolescents
Authors: Joshua J. Gagne, Mengdong He, Brian T. Bateman
Journal: JAMA Pediatrics (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Sténose oesophagienne réfractaire bénigne (SORB): comparaison entre les prothèses biodégradables et les prothèses couvertes classiques
Authors: S Lecleire, A Di Fiore, R Alhameedi, L Thomassin, L Armengol-Debeir, JM Thorel, P Hochain, L Diez, A Charachon, R Dumas, P Ducrotté
Journal: Endoscopy (2019)

Les patients présentant une sténose oesophagienne réfractaire bénigne (SORB), définie par une sténose récidivante après 3 dilatations bien conduites > 15 mm de diamètre, doivent souvent faire l'objet de dilatations itératives ou de pose de prothèse couverte avec un taux de succès sur la dysphagie inconstant et des complications fréquentes, en 1er lieu la migration de la prothèse. Les prothèses biodégradables ont été développées dans cette indication de SORB, pour remédier notamment à ces problèmes de migration de prothèse et de multiplication des anesthésies générales. Le but de l'étude était d'analyser rétrospectivement dans deux centres les 30 derniers malades ayant bénéficié de l'insertion d'une prothèse oesophagienne biodégradable versus 30 malades ayant bénéficié durant la même période d'une prothèse oesophagienne couverte classique dans le cadre d'une SORB.
MORE LESIONS PER PATIENT DETECTED WITH HIGH-QUALITY VERSUS ADEQUATE CLEANSING: A POST HOC ANALYSIS OF UNIFORM SEGMENTAL CLEANSING SCORES USING THE BOSTON BOWEL PREPARATION SCALE
Authors: R Jover, J Manning, S Mokashi, C Hassan
Journal: Endoscopy (2019)

Effective colonoscopy requires colon cleansing success which is usually based on the least clean colon segment; one poorly cleansed segment triggers an overall failure. This complicates the analysis of cleansing quality vs. lesion detection. We therefore analysed the relative lesion detection in patients who had the same cleansing score in all three colon segments.
Real-world Evidence—What Does It Really Mean?
Authors: Chadi Nabhan, Andrew Klink, Vinay Prasad
Journal: JAMA Oncology (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Abstract 1583: Inhibition of proline isomerase Pin1 interrupts the function of the androgen receptor N-terminal domain and suppresses androgen-independent growth of prostate cancer cells
Authors: Jacky K. Leung, Yusuke Imamura, Minoru Kato, Nasrin R. Mawji, Marianne D. Sadar
Journal: Cancer Research (2017)

Abstract Patients with advanced prostate cancer continue to develop lethal castration-resistant prostate cancer (CRPC) despite hormone therapy and maintaining castrate levels of serum androgen. Most CRPC appears to be dependent on the androgen receptor (AR), but instead of the C-terminal ligand-binding domain, it is the N-terminal domain (NTD) harboring a powerful transactivation domain that drives AR transcriptional activity. This was supported by the discovery of AR splice variants (ARv567es and V7) which are constitutively active, do not encode a functional ligand-binding domain, and correlate with poor patient outcome. The AR NTD is intrinsically disordered, but it contains several putative binding sites for Pin1, a proline isomerase specific for phosphorylated-Ser/Thr-Pro motifs. Since the innate ability of the AR NTD to adopt multiple transient structures is important for transactivation of AR, we aimed to determine whether Pin1 regulates motifs within the AR NTD. We tested several known inhibitors of Pin1 in cell-based assays that measure proliferation or transcription mediated by AR. Our results demonstrated that inhibition of Pin1 interrupted the function of the AR NTD. The Pin1 inhibitor juglone effectively and specifically blocked transcription mediated by AR induced by androgen, as well as transactivation of the AR NTD in the presence of IL-6. We found that Pin1 predominantly interacted with a specific region of the AR NTD containing two Pin1 binding sites, and by inhibiting Pin1 the interactions between endogenous AR and STAT3 became attenuated. Furthermore, Pin1 inhibitors were more effective than second-generation anti-androgens in blocking androgen-independent proliferation of LNCaP95 cells driven by AR variants. Here we describe that Pin1 is a critical factor for transcription mediated by AR, regardless of ligand, by regulating the AR NTD. Understanding the molecular mechanisms that may promote AR signaling in the absence of androgen will aid the development of more effective therapies for CRPC. Citation Format: Jacky K. Leung, Yusuke Imamura, Minoru Kato, Nasrin R. Mawji, Marianne D. Sadar. Inhibition of proline isomerase Pin1 interrupts the function of the androgen receptor N-terminal domain and suppresses androgen-independent growth of prostate cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 1583. doi:10.1158/1538-7445.AM2017-1583
Comment on Davis et al. Development and Validation of a Simple Hip Fracture Risk Prediction Tool for Type 2 Diabetes: The Fremantle Diabetes Study Phase I. Diabetes Care 2018;42:102–109
Authors: Petra Bůžková, Joshua I. Barzilay
Journal: Diabetes Care (2019)

In the article by Davis et al. (1), regarding risk factors for hip fracture in people with type 2 diabetes, we note the absence of two risk factors that were not considered and that are relatively easy to assess. The first is cognitive impairment. Approximately 40% of participants with hip fractures have cognitive impairment (2), including ∼20% with dementia. The second factor is an elevated albumin-to-creatinine ratio (ACR)—a manifestation of small vessel disease—which is associated with cognitive impairment and with hip fracture risk (3,4). Both cognitive impairment and microvascular disease are common in people with diabetes.

The association of cognitive impairment and microvascular disease may be understood in two complimentary ways. One is …
Membralin deficiency dysregulates astrocytic glutamate homeostasis, leading to ALS-like impairment
Authors: Lu-Lin Jiang, Bing Zhu, Yingjun Zhao, Xiaoguang Li, Tongfei Liu, Juan Pina-Crespo, Lisa Zhou, Wenxi Xu, Maria J. Rodriguez, Haiyang Yu, Don W. Cleveland, John Ravits, Sandrine Da Cruz, Tao Long, Dongxian Zhang, Timothy Y. Huang, Huaxi Xu
Journal: Journal of Clinical Investigation (2019)

Mechanisms underlying motor neuron degeneration in amyotrophic lateral sclerosis (ALS) are yet unclear. Specific deletion of the ER-component membralin in astrocytes manifested postnatal motor defects and lethality in mice, causing the accumulation of extracellular glutamate through reducing the glutamate transporter EAAT2. Restoring EAAT2 levels in membralin KO astrocytes limited astrocyte-dependent excitotoxicity in motor neurons. Transcriptomic profiles from mouse astrocytic membralin KO motor cortex indicated significant perturbation in KEGG pathway components related to ALS, including downregulation of Eaat2 and upregulation of Tnfrsf1a. Changes in gene expression with membralin deletion also overlapped with mouse ALS models and reactive astrocytes. Our results shown that activation of TNF receptor (TNFR1)-NFκB pathway known to suppress Eaat2 transcription was upregulated with membralin deletion. Further, reduced membralin and EAAT2 levels correlated with disease progression in spinal cord from SOD1-mutant mouse models, and reductions in membralin/EAAT2 were observed in human ALS spinal cord. Importantly, overexpression of membralin in SOD1G93A astrocytes decreased TNFR1 levels and increased EAAT2 expression, and improved motor neuron survival. Importantly, upregulation of membralin in SOD1G93A mice significantly prolonged mouse survival. Together, our study provided a mechanism for ALS pathogenesis where membralin limited glutamatergic neurotoxicity, suggesting that modulating membralin had potentials in ALS therapy.
Response to Comment on Evron et al. Changes in Screening Practices for Prediabetes and Diabetes Since the Recommendation for Hemoglobin A1c Testing. Diabetes Care 2019;42:576–584
Authors: Joshua M. Evron, William H. Herman, Laura N. McEwen
Journal: Diabetes Care (2019)

Stankevich et al. (1) demonstrate that between 69% and 89% of first HbA1c analyses performed in the southwest region of France are performed as screening tests: only 11% to 31% are performed to monitor patients with known diabetes. Of the screening tests performed, 4.1% were diagnostic of diabetes (HbA1c ≥6.5%) and 21.3% were diagnostic of prediabetes (HbA1c 5.7–6.4%) (1). The prevalence of treated diabetes in the …
ENDOSCOPIC RADIOFREQUENCY ABLATION PROLONGS SURVIVAL IN PATIENTS WITH ADVANCED HILAR CHOLANGIOCELLULAR CARCINOMAS
Authors: A Bokemeyer, P Matern, D Bettenworth, F Cordes, T Nowacki, H Heinzow, I Kabar, H Schmidt, H Ullerich, F Lenze
Journal: Endoscopy (2019)

Patients with an unresectable advanced hilar cholangiocellular carcinoma (CCC) suffer from a particularly short life expectancy. Endoscopic radiofrequency ablation (ERFA) of the malignant biliary obstruction may substantially prolong survival in these patients.
EVALUATION OF THE SENSITIVITY OF THE EXPRESS-VIEW MODE OF THE MIROCAM CAPSULE ENDOSCOPY PLATFORM COMPARED TO CONVENTIONAL READING IN OBSCURE GASTROINTESTINAL BLEEDING
Authors: AC Gomes, R Pinho, A Ponte, A Rodrigues, J Rodrigues, M Sousa, JC Silva, J Carvalho
Journal: Endoscopy (2019)

The Express-View mode of the Mirocam capsule endoscopy (CE) platform is a newly introduced feature that aims to decrease the reading time by not capturing small bowel (SB) images considered repetitive. There is no evidence yet that its use can replace conventional reading. The authors aimed to evaluate the proportion of lesions detected by the Express-view reading mode.
A NOVEL ENDOSCOPIC TECHNIQUE IN TREATING PATIENTS WITH ZENKER'S DIVERTICULUM
Authors: I Nedoluzhko, I Pavlov, K Shishin, L Shumkina
Journal: Endoscopy (2019)

To show the advantages of endoscopic cryopharingoesophagomyotomy using a novel technique in the treatment of patients with Zenker's diverticulum.
ENDOSCOPIC TREATMENT VS. SURGERY IN PATIENTS WITH HIGH-RISK EARLY ESOPHAGEAL CANCER
Authors: M Kollar, J Krajciova, J Maluskova, A Pazdro, T Harustiak, D Kodetova, Z Vackova, J Spicak, J Martinek
Journal: Endoscopy (2019)

Esophagectomy is a standard treatment for patients with 'high-risk' early esophageal cancer (EEC) despite a growing evidence that endoscopic treatment could be a safe alternative even for these patients.
Impact of radiographic screening of &gt;34 000 asylum seeker children
Authors: Bert A. Wolters, Onno W. Akkerman, Yvonne Aartsma, Wiel C.M. de Lange, Elisabeth H. Schölvinck, Tjip S. van der Werf, Rob van Hest
Journal: European Respiratory Journal (2019)

<b>Radiographic screening of more than 34 000 asylum seeker children in the Netherlands shows that, after introducing universal screening for latent TB infection, only children ≥12 years old from certain high-endemic countries require screening upon entry.</b>http://bit.ly/2yxLaZf
Ethnic density and other neighbourhood associations for mortality in severe mental illness: a retrospective cohort study with multi-level analysis from an urbanised and ethnically diverse location in the UK
Authors: Jayati Das-Munshi, Peter Schofield, Vishal Bhavsar, Chin-Kuo Chang, Michael E Dewey, Craig Morgan, Robert Stewart, Graham Thornicroft, Martin J Prince
Journal: The Lancet Psychiatry (2019)

Neighbourhood social context might play a role in modifying mortality outcomes in severe mental illness, but has received little attention to date. Therefore, we aimed to assess in an ethnically diverse and urban location the association of neighbourhood-level characteristics and individual-level factors for all-cause, natural-cause, and unnatural-cause mortality in those with severe mental illness.
Apport de la fibroscopie dans l'ingestion d'eau de javel: à propos de 80 cas
Authors: S Bouamama, S Elmansouri, M Tahiri Joutei Hassani, F Haddad, W Hliwa, A Bellabah, W Badre
Journal: Endoscopy (2019)

L'ingestion d'eau de javel constitue une situation fréquemment rencontrée aux urgences. Ce type de détergent ingéré de manière accidentelle ou dans un but d'autolyse pourrait occasionner des lésions du tractus digestif à différents degré de gravité.
CONFOCAL LASER ENDOMICROSCOPY CAN PREDICT MAJOR CLINICAL EVENTS WITH VERY HIGH SENSITIVITY IN PATIENTS WITH INFLAMMATORY BOWEL DISEASES
Authors: E Klenske, R Atreya, S Zundler, S Fischer, M Neurath, T Rath
Journal: Endoscopy (2019)

Probe-based confocal laser endomicroscopy (pCLE) enables in vivo microscopic imaging during ongoing endoscopy. Further, pCLE enables visualization of mucosal barrier dysfunction (MBD) in patients with inflammatory bowel diseases (IBD). With this, pCLE is the only technology allowing functional imaging within the GI tract in IBD patients. Here we evaluated whether assessment of MBD by pCLE can accurately predict major clinical events (MCE) in IBD patients.
Next‐generation sequencing‐defined minimal residual disease before stem cell transplantation predicts acute myeloid leukemia relapse
Authors: Richard D. Press, Garrett Eickelberg, Allison Froman, Fei Yang, Alex Stentz, Ellen M. Flatley, Guang Fan, Jeong Y. Lim, Gabrielle Meyers, Richard T. Maziarz, Rachel J. Cook
Journal: American Journal of Hematology (2019)

In acute myeloid leukemia (AML), the assessment of post-treatment minimal residual disease (MRD) may inform a more effective management approach. We investigated the prognostic utility of next-generation sequencing (NGS)-based MRD detection undertaken before hematopoietic stem cell transplantation (HSCT). Forty-two AML subjects underwent serial disease monitoring both by standard methods, and a targeted 42-gene NGS assay, able to detect leukemia-specific mutant alleles (with >0.5% VAF) (mean 5.1 samples per subject). The prognostic relevance of any persisting diagnostic mutation before transplant (≤27 days) was assessed during 22.1 months (median) of post-transplant follow-up. The sensitivity of the NGS assay (27 MRD-positive subjects) exceeded that of the non-molecular methods (morphology, FISH, and flow cytometry) (11 positive subjects). Only one of the 13 subjects who relapsed after HSCT was NGS MRD-negative (92% assay sensitivity). The cumulative incidence of post-transplant leukemic relapse was significantly higher in the pre-transplant NGS MRD-positive (vs MRD-negative) subjects (P = .014). After adjusting for TP53 mutation and transplant conditioning regimen, NGS MRD-positivity retained independent prognostic significance for leukemic relapse (subdistribution hazard ratio = 7.3; P = .05). The pre-transplant NGS MRD-positive subjects also had significantly shortened progression-free survival (P = .038), and marginally shortened overall survival (P = .068). In patients with AML undergoing HSCT, the pre-transplant persistence of NGS-defined MRD imparts a significant, sensitive, strong, and independent increased risk for subsequent leukemic relapse and death. Given that NGS can simultaneously detect multiple leukemia-associated mutations, it can be used in the majority of AML patients to monitor disease burdens and inform treatment decisions.
Systems thinking deals with complexity and could reduce the risk of burnout
Authors: Heather Gallie
Journal: BMJ (2019)

Samra’s editorial raised the idea of complexity as a factor in physician burnout.1 In complex systems there are multiple interactions that can subtly influence outcome.

Consider the number of professionals a patient meets on admission to hospital, all of whom interact with each other—the system, service, patient, technology, and machinery form a tangled web. Likewise, an …