THU0450 OPTIMISTIC STATUS ASSOCIATES WITH COMPLIANCE TO URATE-LOWERING THERAPY IN GOUT PATIENTS
Authors: W. Zhao, Z. Huang, Y. Huang, Y. Liu, X. Liu, Z. Zhong, S. Chen, T. LI
Journal: Annals of the Rheumatic Diseases (2020)

Background: Compliance to urate-lowering therapy (ULT) is poor in gout patients, which contributes to increased frequency of acute gout attacks, deposition of tophi and urate nephropathy [1]. Optimistic status is probably a potential and considerable factor affecting compliance to ULT in gout patients. Objectives: To compare optimistic status between gout patients and healthy controls, and also between gout patients with good and poor compliance. Relationship between optimistic status and compliance to ULT, sUA target achievement of gout patients were assessed as well. Methods: This was a monocentric and observational study which was performed from August 2018 to December 2019. Adult patients who met the 2015 gout classification criteria were included in this study. The healthy controls were individuals who were free of gout, hyperuricemia and other rheumatic diseases from the physical examination center of our hospital. Demographic data, including age, gender and education were collected from all individuals. Serum uric acid (sUA) were collected from gout patients at enrollment and again after 3 months. Disease duration of gout, visual analogue scale (VAS) of pain were also assessed for gout patients at enrollment. Compliance to ULT was measured using the medication possession ratio (MPR) in the following 3 months. Poor compliance was defined as MPR&lt;0.8 and good compliance was defined as MPR≥0.8. All subjects completed the life orientation test-revised (LOT-R) for optimistic status assessment. Results: Five hundred and thirty gout patients and 307 healthy controls matched by age (41.4±12.3 vs. 42.1±9.3 years), gender (male 97.1% vs. 95.1%) and education (college graduated 54.2% vs. 58.0%) were included in this study. Of the 530 gout patients, the mean disease duration was 5.7±4.9 years, and 292 (55.1%) patients’ MPR were lower than 0.8. There was no statistic difference in LOT-R between gout patients and healthy controls (19.0±2.4 vs. 19.2±2.5, P&gt;0.05) (Table 1). Gout patients with poor compliance (MPR&lt;0.8) had higher level of sUA (525.5±138.0 vs. 471.2±152.5 μmol/L, P&lt;0.05), followup sUA (450.1±154.5 vs. 361.6±120.0 μmol/L, P&lt;0.05) and higher LOT-R (19.6±2.6 vs. 17.8±1.7, P&lt;0.05) than those with good compliance (MPR≥0.8). Of the 292 gout patients with poor compliance, there were only 83 (28.4%) patients achieved sUA target after 3 months, and their LOT-R were significantly lower than those did not achieve sUA target (18.8±2.1 vs. 19.6±2.4, P&lt;0.05). Finally, LOT-R correlated positively with sUA (r=0.131, P&lt;0.05) and followup sUA (r=0.09, P&lt;0.05), but negatively with MPR (r=-0.473, P&lt;0.05) of gout patients (Table 2). Table 1 Demographic and optimistic status of gout patients and healthy controls Variables Gout patients ( n =530) Controls ( n =307) P Age (years) 41.4±12.3 42.1±9.3 0.116 Male gender, n (%) 511 (96.4) 292 (95.1) 0.368 College graduated, n (%) 287 (54.2) 178 (58.0) 0.312 LOT-R 19.0±2.4 19.2±2.5 0.189 LOT-R: life orientation test-revised Table 2 Correlation analysis between LOT-R and clinical variables in gout patients Variables LOT-R r P Age 0 0.994 Disease duration -0.058 0.182 VAS 0.034 0.432 sUA 0.131 0.003* Followup sUA 0.126 0.016* MPR -0.393 &lt;0.001* LOT-R : life orientation test-revised, VAS: visual analogue scale, sUA: serum uric acid, MPR: medication possession ratio *P&lt;0.05 Conclusion: Gout patients share similar optimistic status to healthy controls. However, optimistic status relates to compliance to ULT and sUA target achievement of gout patients. References: [1]Harrold L R, Andrade S E, Briesacher B A, et al. Adherence with urate-lowering therapies for the treatment of gout. Arthritis research &amp; therapy 2009, 11(2):R46. Disclosure of Interests: : None declared