tbuckley/cabot-search huggingface dataset:
Abstract 20373: Multimodality and Multi-Vendor Comparisons of Strain Evaluation by Cardiac Mri
Authors: Jie J Cao, Nora Ngai, Lynette Duncanson, Joshua Cheng, Kathleen Gliganic, Qizhi chen
Journal: Circulation (2017)

Background: Myocardial strain is increasingly recognized as an important assessment for myocardial function. However, there is lack of standardization in strain evaluation by cardiac MRI (CMR). In ...
Abstract 6206: Age-Associated Increases in Pulmonary Artery Systolic Pressure in the General Population
Authors: Carolyn S Lam, Barry A Borlaug, Garvan C Kane, Richard J Rodeheffer, Margaret M Redfield
Journal: Circulation (2008)

In contrast to systemic hypertension, less is known about pulmonary hypertension in the general community. Elevated pulmonary artery systolic pressure (PASP) is frequently seen in elderly persons a...
The Protean Manifestations of Schistosomiasis Mansoni
Authors: Mario R. García-Palmieri, Raúl A. Marcial-Rojas
Journal: Annals of Internal Medicine (2020)

Excerpt Since Bilharz discovered the parasite in 1851, there have been numerous publications on schistosomiasis. The clinical picture of schistosomiasis mansoni has been presented by many observers...
COVID-19 and vaping: risk for increased susceptibility to SARS-CoV-2 infection?
Authors: Kielan Darcy McAlinden, Mathew Suji Eapen, Wenying Lu, Collin Chia, Greg Haug, Sukhwinder Singh Sohal
Journal: European Respiratory Journal (2020)

With great interest we read and commend the study done by Russo et al. [1], highlighting their findings that nicotine induces an increase in angiotensin-converting enzyme 2 (ACE-2) expression in human bronchial epithelial cells (HBEpC) and is mediated by α7-subtype nicotinic receptors (α7-nAChR). It raises the concern that all electronic nicotine-delivery systems may put users at greater risk of succumbing to coronavirus disease 2019 (COVID-19). Absolute cessation of any tobacco product in any form: implications for COVID-19 <https://bit.ly/3cyk9ra> Clifford Craig Foundation Launceston General Hospital, Rebecca L. Cooper Medical Research Foundation.
Covid-19: face masks could foster distrust and blame
Authors: Frances M King
Journal: BMJ (2020)

We should advise the public to wear face masks"-Greenhalgh and colleagues detail the absence of an evidence base to support this advice and, along with Javid and colleagues, argue that population benefits are plausible and harms unlikely. 1 2My experience of communication difficulties while working in a hospital during the coronavirus epidemic leads me to the opposite conclusion-potential harms are likely.
A Cardiac Computed Tomography–Based Score to Categorize Mitral Annular Calcification Severity and Predict Valve Embolization
Authors: Mayra Guerrero, Dee Dee Wang, Amit Pursnani, Mackram Eleid, Omar Khalique, Marina Urena, Michael Salinger, Susheel Kodali, Tatiana Kaptzan, Bradley Lewis, Nahoko Kato, Hector M. Cajigas, Olaf Wendler, David Holzhey, Ashish Pershad, Christian Witzke, Sami Alnasser, Gilbert H.L. Tang, Kendra Grubb, Mark Reisman, Philipp Blanke, Jonathon Leipsic, Eric Williamson, Patricia A. Pellikka, Sorin Pislaru, Juan Crestanello, Dominique Himbert, Alec Vahanian, John Webb, Rebecca T. Hahn, Martin Leon, Isaac George, Vinayak Bapat, William O’Neill, Charanjit Rihal
Journal: JACC. Cardiovascular imaging (2020)
POST-POLYPECTOMY SURVEILLANCE COLONOSCOPY, ARE WE FOLLOWING THE GUIDELINES?
Authors: N Abu-Freha, MA Tailakh, J Elkrinawi, HA Kaf, A Philip, D Schwartz, A Yehia, O Etzion
Journal: Endoscopy (2020)

Aims The Aim of this study was to assess the adherence of gastroenterologists to International Post-Polypectomy guidelines.
ARTIFICIAL INTELLIGENCE COMBINED WITH LCI YIELDS IN HIGHEST ACCURACY AND DETECTION OF COLORECTAL POLYPS, INCLUDING SESSILE SERRATED LESIONS
Authors: H Neumann, V Sivanathan, F Rahman, PR Galle
Journal: Endoscopy (2020)

Aims Linked color imaging (LCI) has shown its effectiveness in multiple randomized controlled trials for enhanced colorectal polyp detection. Most recently, artificial intelligence (AI) with deep learning through convolutional neural networks has dramatically improved and is increasingly recognized as a promising new technique enhancing colorectal polyp detection. Study aim was to evaluate a new developed deep-learning computer-aided detection (CAD) system in combination with LCI for colorectal polyp detection.
A Changing Paradigm for the Treatment of Intermediate-Stage Hepatocellular Carcinoma: Asia-Pacific Primary Liver Cancer Expert Consensus Statements
Authors: Masatoshi Kudo, Kwang-Hyub Han, Sheng-Long Ye, Jian Zhou, Yi-Hsiang Huang, Shi-Ming Lin, Chung-Kwe Wang, Masafumi Ikeda, Stephen Lam Chan, Su Pin Choo, Shiro Miyayama, Ann Lii Cheng
Journal: Liver Cancer (2020)

The Asia-Pacific Primary Liver Cancer Expert (APPLE) Consensus Statement on the treatment strategy for patients with intermediate-stage hepatocellular carcinoma (HCC) was established on August 31, 2019, in Sapporo, Hokkaido during the 10th Annual APPLE Meeting. This manuscript summarizes the international consensus statements developed at APPLE 2019. Transarterial chemoembolization (TACE) is the only guideline-recommended global standard of care for intermediate-stage HCC. However, not all patients benefit from TACE because intermediate-stage HCC is a heterogeneous disease in terms of tumor burden and liver function. Ten important clinical questions regarding this stage of HCC were raised, and consensus statements were generated based on high-quality evidence. In intermediate-stage HCC, preservation of liver function is as important as achieving a high objective response (OR) because the treatment goal is to prolong overall survival. Superselective conventional TACE (cTACE) is recommended as the first choice of treatment in patients eligible for effective (curative) TACE, whereas in patients who are not eligible, systemic therapy is recommended as the first choice of treatment. TACE is not indicated as the first-line therapy in TACE-unsuitable patients. Another important statement is that TACE should not be continued in patients who develop TACE failure/refractoriness in order to preserve liver function. Targeted therapy is the recommended first-line treatment for TACE-unsuitable patients. Especially, the drug, which can have higher OR rate, is preferred. Immunotherapy, transarterial radioembolization, TACE + targeted therapy or other modalities may be considered alternative options in TACE-unsuitable patients who are not candidates for targeted therapy. Better liver function, such as albumin-bilirubin grade 1, is an important factor for maximizing the therapeutic effect of systemic therapy.
CLINICAL OUTCOMES OF ENDOSCOPIC SUBMUCOSAL DISSECTION FOR LATERALLY SPREADING TUMORS INVOLVING THE APPENDICEAL ORIﬁCE
Authors: M Takita, K Ohata, M Nobuyuki
Journal: Endoscopy (2020)

Aims Though colorectal ESD has become standard therapy, the locations which are difficult to treat anatomically are still exist. Lesions involving the appendiceal orifice are known to be difficult to treat. The aim of this study is to evaluate the clinical outcomes of endoscopic treatment for the lesions near the appendiceal orifice.
MALLORY WEISS TEAR RELATED UPPER GI BLEEDING: AN INTERNATIONAL MULTICENTRE STUDY
Authors: JE Tham, L Lynch, SB Laursen, L Laine, HR Dalton, N Michell, J Ngu, M Schultz, AJ Morris, E Redondo-Cerezo, AJ Stanley
Journal: Endoscopy (2020)

Aims Mallory Weiss tears (MWT) are relatively uncommon causes of upper GI bleeding (UGIB). Patients with these lesions are generally considered at low risk of poor outcome, although data are relatively limited. There is also uncertainty about which patients with MWT require endoscopic therapy and which modality should be applied. We aimed to describe an international cohort of patients presenting with UGIB secondary to MWT.
Safety of Seasonal Influenza Vaccination in Hospitalized Surgical Patients
Authors: Sara Y. Tartof, Lei Qian, Gunter K. Rieg, Kalvin C. Yu, Lina S. Sy, Hung Fu Tseng, Rulin C. Hechter, Steven J. Jacobsen
Journal: Annals of Internal Medicine (2016)

Influenza vaccination is recommended before discharge for surgical inpatients who have not yet been vaccinated. Vaccination rates are low in this population, perhaps due to concerns that adverse ef...
ENDOSCOPIC TREATMENT OF CHRONIC PANCREATITIS IN PEDIATRIC POPULATION: LONG-TERM EFFICACY AND SAFETY
Authors: D Kohoutova, A Tringali, G Paparella, V Perri, I Boškoski, J Hamanaka, G Costamagna
Journal: Endoscopy (2019)

Purpose of study was to analyse safety and long-term efficacy of endoscopic treatment in children with CP.
VALUE OF ENDOSCOPIC ULTRASOUND GUIDED FINE NEEDLE ASPIRATION (FNA) IN THE DIAGNOSIS OF SOLID PANCREATIC MASSES
Authors: A Zazour, W Khannoussi, G Kharrasse, Z Ismaili
Journal: Endoscopy (2020)

Methods A Retrospective study, over a period of 3 years, included all patients who had FNA of pancreatic solid masses. Endoscopic ultrasound guided FNA was performed under sedation, using fine needle of 22G or 19G, depending on the location of pancreatic masses. The techniques used were Slow Pull and aspiration (10-20cc). The samples were spread on slides and/or put in cytolytã. Number of passage during all the procedure was three, except if it was a hemorrhagic specimen.
UPPER GASTROINTESTINAL BLEEDING SECONDARY TO BURKITT LYMPHOMA, AN UNCOMMON BUT VERY AGGRESSIVE CAUSE OF GASTRIC CANCER
Authors: P Florez-Diez, N Rodriguez-Ferreiro, V Jimenez-Beltran, M Fraile-Lopez, O Gonzalez-Bernardo, A Suarez-Noya, C Del Caño-Cerdan, A Nieto-Jara, L Carballo-Folgoso, M Celada-Sendino, A Gejo-Beneitez
Journal: Endoscopy (2020)

Lymphoma is the second most common type of gastric cancer, especially MALT and diffuse large B cells lymphomas. A very rare but highly aggressive lymphoma is Burkitt lymphoma. Man, 72 years with epigastralgia, melena and anemia. In urgent gastroscopy, a large excavated ulcer is observed on the underside of the antrum (1-3). Biopsies show CD20+/bcl-6+/CD10+ lymphoid cells on the lamina propria, over-expression of c-myc and Ki67>90%, compatible with Burkitt lymphoma. PET/CT (4) shows large gastric hypermetabolic mass, with multiple intra-abdominal nodules. Chemotherapy (R-DA-EPOCH scheme) achieves complete metabolic remission in PET/CT at the end of treatment (5).
CHOLANGIOSCOPY-GUIDED LITHOTRIPSY OF CYSTIC DUCT REMNANT STONES
Authors: MR Pineda-De Paz, FJ Flores-Renteria, LA Waller-Gonzalez, R Soto-Solis
Journal: Endoscopy (2020)

Male with past history of Billroth II and cholecystectomy. He presented with biliary colic due to remnant cystic duct lithiasis which was resolved with cholangioscopy and EHL.
CLINICAL OUTCOMES OF PALLIATIVE GASTRODUODENAL AND JEJUNAL STENTING IN PATIENTS WITH ADVANCED CANCER: RESULTS OF A TWO-CENTER RETROSPECTIVE STUDY
Authors: S Davydova, A Fedorov, O Yun, A Klimov
Journal: Endoscopy (2020)

Aims Palliative self-expandable metal stent [SEMS] placement for malignant gastroenteral stenosis can be challenging in advanced cancer, especially in cases of total gastric involvement and combined duodenal and biliary obstruction. The study was aimed to evaluate early and long-term outcomes of gastroenteral stenting.
Helen Salisbury: GPs still have no access to coronavirus testing
Authors: Helen Salisbury
Journal: BMJ (2020)

Once upon a time (two months ago), if I saw a patient with a notifiable infectious disease I’d make a clinical diagnosis, usually send a sample to the hospital laboratory, and email the local public health department for relevant follow-up and contact tracing. This worked for food poisoning, allowing the source to be pinpointed, and for childhood infections, helping us to spot gaps in our immunisation programme. This system worked.

Now, in the middle of this pandemic, I’m struggling to make clinical diagnoses of this new disease. Some cases are clear—particularly the triad of fever, dry cough, and shortness …
Evidence for Early Central Nervous System Involvement in the Acquired Immunodeficiency Syndrome (AIDS) and Other Human Immunodeficiency Virus (HIV) Infections
Authors: Igor Grant, J. Hampton Atkinson, John R. Hesselink, Caroline J. Kennedy, Douglas D. Richman, Stephen A. Spector, J. Allen McCUTCHAN
Journal: Annals of Internal Medicine (2020)

Abstract Although a high prevalence of central nervous system disease is seen in persons with the acquired immunodeficiency syndrome (AIDS), the natural history of brain involvement with human immu...
Pulmonary embolism in patients with COVID-19 pneumonia
Authors: Florian Bompard, Hippolyte Monnier, Ines Saab, Mickael Tordjman, Hendy Abdoul, Laure Fournier, Olivier Sanchez, Christine Lorut, Guillaume Chassagnon, Marie-Pierre Revel
Journal: European Respiratory Journal (2020)

<b>This study reports an overall 24% (95% CI 17–32%) cumulative incidence of pulmonary embolism in patients with COVID-19 pneumonia, 50% (30–70%) in ICU and 18% (12–27%) in other patients</b>https://bit.ly/35s7hjm
CLINICAL SIGNIFICANCE OF BILE JUICE AND UPPER GASTROINTESTINAL ENDOSCOPIC FINDINGS, BEFORE PERFORMING ERCP
Authors: K Ryu, C Im, M Kang
Journal: Endoscopy (2020)

Aims An impacted bile duct stone is a risk factor for developing acute suppurative cholangitis (ASC). No study has classified biliary obstruction caused by impacted bile duct stones into complete and incomplete obstruction. Complete obstruction would show no bile juice on esophagogastroduodenoscopy (EGD), and it is more likely to be accompanied with ASC than with incomplete obstruction.
Swimming and Grommets
Authors: N J Marks, R P Mills
Journal: Journal of the Royal Society of Medicine (1983)

The dictum that patients who have plastic ventilation tubes (grommets) inserted in their tympanic membranes should not go swimming is questioned. A theoretical assessment is made of the pressure necessary to push water through a grommet. This value is compared with practical observations. These values are discussed with reference to chemical and bacteriological hazards and it is concluded that water is unlikely to enter the middle ear in surface swimming, and even when diving underwater the chances of setting up an otitis media must be small.
Platelet-derived growth factor. Structure, function, and roles in normal and transformed cells.
Authors: T F Deuel, J S Huang
Journal: Journal of Clinical Investigation (1984)

not exposed to serum; however, at sites of injury, platelets secrete PDGF, and blood coagulation reactions are initiated, providing locally in this instance a serum-like environment for cell growth.Mitogenic responses to PDGF are mediated through binding to the PDGF receptor/protein tyrosine kinase PDGF stimulates specific target cells by binding to cell surface receptors which, in turn, mediate a cascade of events that 669 Platelet-derived Growth Factor
VASCULAR COMPLICATIONS OF CHRONIC PANCREATITIS AND ROLE OF EUS IN MANAGEMENT: EXPERIENCE FROM TERTIARY CARE CENTER IN NORTHWESTERN INDIA
Authors: V Goel, A Jhajharia, V Chauhan, M Ameta, V Agarwal
Journal: Endoscopy (2020)

Aims To study the various vascular complications associated with chronic pancreatitis and role of EUS in their management.
Barriers to breast cancer screening among Navajo Nation women.
Authors: Rahul S. Mhaskar, Sally A. Joe, Lydia Hubbard-Pourier, Louise Canfield
Journal: Cancer Research (2006)

5377  Background. In the past two decades, the Arab American population has increased over 40% with over a million Arab Americans currently in the US. Michigan has the highest concentration of Arab Americans among states. Individuals of Arab descent comprised 1.2% of the total population in 2000. Yet, it is believed that census underestimates the population of Arab Americans and that the estimated population size is at least three times that calculated by census. Cancer is a major cause of morbidity and mortality within this population yet the distribution of cancer among Arab Americans is poorly defined. To examine the utilization of screening for breast, cervical, and colorectal cancers, data from the Special Cancer Behavioral Risk Factor Survey (SCBRFS) were analyzed. Methods. The SCBRFS uses telephone surveillance with a disproportionate stratified, random-digit dial sampling design. The target population for the SCBRFS consisted of Michigan men and women aged 50 years and older. The SCBRFS over-sampled for African Americans, American Indians, Hispanics, and Arab Americans. A total of 3,649 interviews were completed. The Arab American component of the SCBRFS included 398 interviews. This study was reviewed and approved by Institutional Review Boards. Data were weighted to adjust for number of phone lines in households, unequal sampling rate between listed and non-listed numbers within strata, and the disproportionate sampling. Calculations of prevalence estimates and confidence intervals were performed using SUDAAN, a statistical computing program designed for analyzing multistage sample surveys data Results. In 2002, 65.2% (95% CI: 88.6%-41.8%) of eligible Arab American women age reported that they had appropriate breast cancer screening, 76.9% (95% CI: 93.7%-60.1%) reported that they had a Pap test within the past 3 years, and 34.0% (95% CI: 51.7%-16.3%) of Arab American men and women reported that they had a lower gastrointestinal (GI) endoscope within the past 10 years. In comparison, 64.1% (95% CI: 69.2%-59.0%) of eligible women within the General Population reported that they had breast cancer screening, 86.5% (95% CI: 89.5%-83.5%) had received a Pap test within the past 3 years, and 45.5% (95% CI: 49.5%-41.5%) of men and women age 50 years and older within the General Population had a lower GI endoscope within the past 10 years. Conclusion. There is disparity in age appropriate cancer screening for cancers such as cervical and colorectal cancers in this underserved hard-to- reach community. Culturally competent tailored interventions and outreach efforts are needed to increase utilization of life saving early detection and ultimately reduce cancer morbidity in Arab-American populations.
Despite Gains, Progress Toward TB Elimination Has Slowed
Authors: Bridget M. Kuehn
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A NATIONAL SURVEY OF SAFETY ACROSS UK ENDOSCOPY SERVICES
Authors: S Ravindran, P Bassett, T Shaw, M Dron, R Broughton, H Griffiths, D Keen, E Wood, C Healey, J Green, H Ashrafian, A Darzi, S Thomas-Gibson
Journal: Endoscopy (2020)

Aims To understand factors related to safety across UK endoscopy in line with the Joint Advisory Group on GI Endoscopy (JAG) ‘Improving Safety and Reducing Error in Endoscopy’ (ISREE) strategy.
RARE-05. BRAF-V600E MUTANT PAPILLARY CRANIOPHARYNGIOMA DRAMATICALLY RESPONDS TO COMBINATION BRAF AND MEK INHIBITORS
Authors: Ashley Roque, Yazmin Odia
Journal: Neuro-Oncology (2016)

We present a patient with a papillary craniopharyngioma harboring a BRAF-V600E mutation that was successfully treated with combination combination BRAF (tramatenib) and MEK (dabrafenib) inhibitor therapy. Optimal treatment remains unclear for craniopharyngiomas that recur after maximal resection and radiotherapy. Tumor invasion and/or attempted surgical resection often result in notable morbidity. There is no approved chemotherapy for recurrent tumors. Brastantinos et al, recently showed most papillary craniopharyngiomas in adults harbor the BRAF-V600E mutation, resulting in constitutive activation of the MEK/ERK pathway. BRAF inhibitors with or without concurrent MEK inhibitor are proven effective in malignant melanoma and hairy cell leukemia expressing BRAF-V600E. Recent trials of BRAF and MEK inhibitors in other solid tumors are showing promising early results. To date, two patients with papillary craniopharyngiomas showed successful response to BRAF targeted therapy, either vemurafenib monotherapy or combination tramatenib and dabrafenib therapy. Our case represents the third papillary craniopharyngioma successfully treated with BRAF targeted therapy, specifically dabrafenib 150 mg orally twice daily and trametinib 2 mg orally once. Aside from expected and transient fevers, she experienced no significant toxicity. Her tumor had rapidly progression after partial resection and involved field radiation, yet combination BRAF and MEK inhibition has reduced the tumor by >75% by 5 months, with corresponding marked decrease in metabolic activity in the tumor and normalization of cortical metabolic activity on FDG-PET. Though her panhypopituitarism proved permanent, she continues to improve neurologically. Our case again highlights the oncogenic role of BRAF mutations in papillary craniopharyngiomas and the potential benefit of BRAF targeted therapy in tumors harboring the BRAF-V600E mutation.
EFFECTIVENESS AND SAFETY OF ENDOSCOPIC SUBMUCOSAL DISSECTION OF GASTROINTESTINAL LESIONS: A PROSPECTIVE WESTERN CENTER EXPERIENCE
Authors: S Sferrazza, M Maida, M Jovani, F Vieceli, G de Pretis, R Maselli, A Repici
Journal: Endoscopy (2020)

Aims Endoscopic submucosal dissection (ESD) allows ‘en-bloc’ resection of superficial gastrointestinal neoplasms, which has implications for complete excision and pathological analysis. This study aimed to assess the effectiveness and safety of ESD as treatment for gastrointestinal lesions in a prospective western cohort.
EFFECTIVENESS OF PREMEDICATION WITH SYMETICHONE AND N-ACETYLCYSTEINE TO IMPROVE VISIBILITY DURING UPPER GI ENDOSCOPY: A RANDOMIZED CONTROLLED TRIAL
Authors: S Romeo, G Manfredi, E Iiritano, S Alicante, C Londoni, G Brambilla, FT Menozzi, R Bertè, E Buscarini
Journal: Endoscopy (2020)

Aims During esophagogastroduodenoscopy (EGDS) bubbles, bile and mucus often compromise the endoscopic visualization. Consensus about the importance of tensioactive and mucolytic drugs such as symetichone (SIM) and N-acetylcysteine (NAC) is lacking in Western world.
Nuclear receptor PXR targets AKR1B7 to protect mitochondrial metabolism and renal function in AKI
Authors: Xiaowen Yu, Man Xu, Xia Meng, Shumin Li, Qianqi Liu, Mi Bai, Ran You, Songming Huang, Li Yang, Yue Zhang, Zhanjun Jia, Aihua Zhang
Journal: Science Translational Medicine (2020)

PXR is crucial for protecting against AKI by targeting the AKR1B7/mitochondrial metabolism axis.