tbuckley/cabot-search huggingface dataset:
An Italian sacrifice to the COVID-19 epidemic
Authors: Stefano Nava, Roberto Tonelli, Enrico M. Clini
Journal: European Respiratory Journal (2020)

As reported by Newsweek magazine on 4 April 2020 [1], coronavirus has killed over 100 doctors and nurses around the world, nearly half of whom are reported to be in Italy. This report, however, underestimated the size of the problem. To date, 151 doctors and more than 40 nurses have died in Italy from coronavirus disease 2019 (COVID-19). The report of Italian doctors who died during the COVID-19 outbreak should inform us not to forget <https://bit.ly/3cbSbkU>
IRAK4 inhibition: a promising strategy for treating RA joint inflammation and bone erosion
Authors: Sadiq Umar, Karol Palasiewicz, Katrien Van Raemdonck, Michael V. Volin, Bianca Romay, M. Asif Amin, Ryan K. Zomorrodi, Shiva Arami, Mark Gonzalez, Vikram Rao, Brian Zanotti, David A. Fox, Nadera Sweiss, Shiva Shahrara
Journal: Cellular and Molecular Immunology (2020)
EFFECTIVENESS OF ENDOSCOPIC RESECTION FOR COLORECTAL LESIONS &gt; 20 MM
Authors: I Pita, L Ferreira, R Castro, I Marques-Sá, C Pinto, P Bastos, C Brandão, E Cardoso, J Lage, D Libânio, P Pimentel-Nunes, T Pinto-Pais, R Silva, M Dinis-Ribeiro
Journal: Endoscopy (2020)

Aims Endoscopic removal of large colonic polyps is technically more demanding and should be attempted by experienced endoscopists. Furthermore, larger lesions have higher risk of invasive carcinoma, in which cases, en bloc resection is mandatory to ensure a “curative” endoscopic resection – this can be unfeasible with endoscopic mucosal resection(EMR) or polipectomy. An alternative method is endoscopic submucosal dissection(ESD), which is associated with longer learning curves, longer procedure times and higher complication rates. Our aim is to evaluate the effectiveness and safety of endoscopic resection techniques for the treatment of colonic lesions > 20 mm.
PANCREATOSCOPY-GUIDED ELECTROHYDRAULIC LITHOTRIPSY FOR THE TREATMENT OF OBSTRUCTIVE DISTAL MAIN PANCREATIC DUCT STONES: A PROSPECTIVE CONSECUTIVE CASE SERIES (PELSTONE STUDY)
Authors: S van der Wiel, P Stassen, PJ de Jonge, D de Jong, JW Poley, M Bruno
Journal: Endoscopy (2020)

Aims Pancreatoscopy-guided electrohydraulic lithotripsy (EHL) has shown potential in the treatment of patients with obstructive chronic calcifying pancreatitis (CCP), but is used as second-line therapy after extracorporeal shockwave lithotripsy (ESWL). We aimed to investigate the efficacy and safety of EHL as first-line therapy in patients with CCP of the distal pancreatic duct (PD).
Jacob Plange-Rhule
Authors: Ali Jawad
Journal: BMJ (2020)

After qualifying, Jacob Plange-Rhule came to the UK to study renal physiology in Manchester. Soon after he obtained his PhD, he returned to Ghana to train in internal medicine. He became consultant physician in the Department of Medicine, Komfo Anokye Teaching Hospital (KATH), where he started hypertension and renal clinics. Later on, he became head of nephrology services at KATH …
ENDOSCOPIC MYOTOMY IN ZENKER´S DIVERTICULUM - EFFICIENCY, COMPLICATIONS AND RECCURRENCE RATE
Authors: F Straulino, A Genthner, S Kangalli, I Reiffenstein, A Eickhoff
Journal: Endoscopy (2020)

Aims These days endoscopic myotomy in patients with Zenker’s diverticulum is an established therapy. No need for general anaesthesia and less invasivness are advantages of the endoscopic therapy, but the high recurrence rate compared to the surgical therapeutic options are a problem. In this retrospective study we report the efficiency and complications in patients treated endoscopic for Zenker’s diverticulum a tour hospital since 2010.
Immune response in acute hepatitis C: Enumeration of virus specific CD8+T cells with ELISPOT assay and tetramers
Authors: N H Gruener, F Lechner, T J Gerlach, C M Jung, H M Diepolder, R Zachoval, W W Schraut, T Santanonio, P Klenerman, G R Pape
Journal: Hepatology (1999)
SUBMUCOSAL TUNNELLING ENDOSCOPIC RESECTION (STER) OF A RECTAL LEIOMYOMA
Authors: MF de Lima, N Nunes, CC Rebelo, DB Moura, VC Santos, AC Rego, JR Pereira, N Paz, MA Duarte
Journal: Endoscopy (2020)

A 45-year-old male patient performed colonoscopy for abdominal pain. A rectal subepithelial lesion of 10 mm was identified and further characterized with endoscopic ultrasound as an hypoechogenic homogeneous well-defined lesion of the second layer, measuring 9.1x10.8 mm. Considering the diagnostic possibility of gastrointestinal stromal tumour, the lesion was resected using a submucosal tunnelling endoscopic resection technique. A 20 mm incision was made under the lesion, after submucosal injection. A submucosal tunnel was created dissecting the submucosal fibers and exposing the lesion. En bloc resection of the lesion was then performed. Finally, the incision was closed using hemostatic clips.
ACETIC ACID SPRAY AND BLUE LIGHT IMAGING PRIOR TO ENDOSCOPIC RESECTION OF SESSILE SERRATED ADENOMA: A VIDEO CASE
Authors: P Hedenström, S Yamamoto, J Varkey
Journal: Endoscopy (2020)

Aims Sessile serrated lesions (SSLs) are sometimes difficult to delineate. We demonstrate the usage of acetic acid (AA) in combination with Blue Light Imaging (BLI) for SSL.
NATIONAL RUSSIAN REGISTRY OF CHOLANGIO-PANCREATOSCOPY: MULTI-CENTER ASSESSMENT OF THE FIRST EXPERIENCE OF USING THE DIGITAL SINGLE-OPERATOR ENDOSCOPY OF BILIARY AND PANCREATIC DUCTS
Authors: S Budzinskiy, E Fedorov, S Shapovalianz, D Novikov, S Gabriel, V Dynko, M Bykov, V Shava, I Trusov, D Gladyshev
Journal: Endoscopy (2020)

Aims To evaluate possibilities and adverse events of diagnostic and therapeutic indirect peroral cholangiopancreatoscopy (POC)at the stage of implementation in Russia, using the national registry.
RISK FACTORS FOR SUCCESS AND COMPLICATIONS AFTER ENDOSCOPIC SPHINCTEROTOMY FOR BILE DUCT STONES: A 17- YEAR EXPERIENCE WITH 2137 CASES
Authors: IDA Sanmartin, JC Pereira Lima, G Pereira Lima, IA Avila
Journal: Endoscopy (2020)

Aims Risk factors for post-ERCP complications are well-studied. However, risk factors for complications and success after endoscopic sphicterotomy for stone management, the main indication of ERCP, are poorly-determined. The aim of this study is to verify risk factors for mortality, complications and success after sphincterotomy (EST)with attempted stone retrieval.
EUS-GUIDED COMPLETE EMBOLIZATION OF VOLUMINOUS GASTRIC VARICES USING COILS AND GLUE INJECTIONS IN ONE SESSION
Authors: A Garcia-Sumalla, S Maisterra, J Velasquez-Rodriguez, F Bas-Cutrina, A Amador, J Castellote, JB Gornals
Journal: Endoscopy (2020)

Complete embolization technique of bulky IGV1 in a single session, using a combined placement of coils and glue injection, guided by EUS and fluoroscopy. A 78-year-old patient with autoimmune liver cirrhosis had hematemesis with hemodynamic instability.
Lymphoid tissue inducer cells: Identification of a novel immune cell within the breast tumour microenvironment and its role in promoting tumour cell invasion
Authors: S Irshad, K Lawler, R Evans, F Flores-Borja, J Monypenny, A Grigoriadis, G Fruhwith, S Poland, P Barber, B Vojnovic, P Ellis, A Tuftt, T Ng
Journal: Cancer Research (2013)
Changes in long term survival after diagnosis with common hematologic malignancies in the early 21st century
Authors: Dianne Pulte, Lina Jansen, Hermann Brenner
Journal: Blood Cancer Journal (2020)

Abstract Five-year survival has increased for many hematologic malignancies in the 21st century. However, whether this has translated into greater long-term survival is unknown. Here, we examine 10- and 20-year survival for patients with multiple myeloma (MM), acute lymphoblastic leukemia (ALL), acute myeloblastic leukemia (AML), chronic lymphoid leukemia (CLL), chronic myeloid leukemia (CML), non-Hodgkin lymphoma (NHL), and Hodgkin lymphoma (HL). Data were extracted from the Surveillance, Epidemiology, and End Results-9 database. Patients age 15+ with the above malignancies were included. The newly developed boomerang method was used to examine 10- and 20-year relative survival (RS) for patients in 2002–2006 and 2012–16. Ten and 20-year RS increased for each malignancy examined, with increases ranging from +4.4% units for 20-year RS for AML to +23.1% units for 10-year RS for CML. Ten year RS was &gt;50% in 2012–16 for patients with CLL, CML, HL, NHL, and DLBCL, at 77.1%, 62.1%, 63.9%, 64.5%, and 63.0%, respectively. Survival dropped between 10 and 20 years after diagnosis for most malignancies. Long-term survival is increasing for common hematologic malignancies, but late mortality is an ongoing issue. Further study of long-term outcomes in curable malignancies to determine the reason for these later decreases in survival is indicated.
IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemia
Authors: Chunhua Song, Zheng Ge, Yali Ding, Bi-Hua Tan, Dhimant Desai, Krishne Gowda, Shantu Amin, Raghavendra Gowda, Gavin P. Robertson, Feng Yue, Suming Huang, Vladimir Spiegelman, Jonathon L. Payne, Mark E. Reeves, Zafer Gurel, Soumya Iyer, Pavan Kumar Dhanyamraju, Meixian Xiang, Yuka Imamura Kawasawa, Nathalia M. Cury, José Andrés Yunes, Mary McGrath, Joe Schramm, Ruijun Su, Yiping Yang, Zhijun Zhao, Xiaoguang Lyu, Markus Muschen, Kimberly J. Payne, Chandrika Gowda, Sinisa Dovat
Journal: Blood (2020)
CAN WE AMELIORATE THE SAFETY OF INTRADUCTAL RADIOFREQUENCY ABLATION FOR PERSISTENT DYSPLASIA AFTER ENDOSCOPIC AMPULLECTOMY?
Authors: L Bruwier, C Meunier, EL Leung-Ki, AI Lemaistre, R Bourdariat, B Napoleon
Journal: Endoscopy (2020)

Aims After endoscopic ampullectomy, intraductal adenoma may persist. Intraductal radiofrequency ablation (ID-RFA) is a potential alternative to avoid surgery. In a previous trial, acute pancreatitis and biliary stenosis were noted in 15% of cases, respectively. Systematic pancreatic and biliary stenting could potentially prevent these complications. This retrospective study aimed to evaluate the safety profile of ID-RFA when associated with prophylactic stenting.
COMPARISON OF TWO BOWEL PREPARATION METHODS FOR COLONOSCOPY IN CHILDREN
Authors: A Shavrov, E Mukhametova, D Morozov, A Shavrov, V Azarova, O Savvateeva
Journal: Endoscopy (2020)

Aims To compare two methods of bowel preparation for colonoscopy in children, that is officially allowed in Russia: natrium picosulphate with magnesium citrate (NP+MC) vs enemas.
Blood eosinophils predict inhaled fluticasone response in bronchiectasis
Authors: Stefano Aliberti, Giovanni Sotgiu, Francesco Blasi, Laura Saderi, Tomas Posadas, Miguel Angel Martinez Garcia
Journal: European Respiratory Journal (2020)

The use of inhaled corticosteroids (ICS) in patients with bronchiectasis is a matter of debate [1]. International registries report up to 42% of bronchiectasis patients receiving ICS, although several guidelines recommend their prescription only in the presence of specific comorbidities ( e.g. allergic bronchopulmonary aspergillosis (ABPA), asthma, COPD, and inflammatory bowel disease) or of eosinophilic inflammation [2, 3]. Assessment of eosinophil counts in sputum is not considered, to date, a standard of care. Blood eosinophils have been shown to be a predictor of ICS response in COPD and asthma [4, 5]. The identification of a specific population of bronchiectasis patients who might respond to ICS is key. Response to ICS can be measured in bronchiectasis patients evaluating not only the reduction of exacerbations but also the improvement of their quality of life (QoL). We hypothesised that bronchiectasis patients with a high blood eosinophil count can benefit from ICS in terms of a clinically meaningful improvement of QoL. 6-month treatment with inhaled fluticasone propionate significantly improved quality of life in bronchiectasis patients who show a blood eosinophil counts ≥3%. https://bit.ly/3fsn4na
18F-FDG PET/CT of a Rare Case of an Adenomatoid Tumor of the Adrenal Gland
Authors: Matthieu Dietz, Sophie Neyrand, Anthony Dhomps, Myriam Decaussin-Petrucci, Jeremie Tordo
Journal: Clinical Nuclear Medicine (2020)

Abstract A 28-year old man, with previous history of chronic abdominal pain, was referred to our nuclear medicine center for an 18 F-FDG PET/CT following the fortuitous discovery of a 48-mm right adrenal gland lesion of heterogeneous density at the CT scan. The PET/CT showed an isolated heterogeneous significant uptake evocative of neoplasia. Surprisingly, the anatomopathological analysis after surgery revealed an adenoid tumor of the adrenal gland. This case of a rare benign tumor can be a source of false-positive and mimicking malignancies in the exploration of adrenal lesions.
ENDOANGEL, AN ARTIFICIAL INTELLIGENCE, IMPROVES ENDOSCOPY QUALITY AND DETECTS EARLY GASTRIC CANCER IN A MULTI-CENTER RANDOMIZED CONTROLLED TRIAL
Authors: X He, L Wu, H Yu
Journal: Endoscopy (2020)

Aims Qualified esophagogastroduodenoscopy (EGD) is considered as a prerequisite for detecting early gastric cancer (EGC). Whether ENDOANGEL, an artificial intelligence (AI), can be used as an effective quality monitoring tool needs to be verified. Thus, a multi-center randomized controlled trial was implemented to verify the quality monitoring function of ENDOANGEL and to test the performance of ENDOANGEL on detecting EGC in clinical scenes.
IMAGING FINDING OF SMALL STONES IS ASSOCIATED TO A HIGHER RISK OF UNNECESSARY ERCP: RESULTS OF A RETROSPECTIVE, MULTICENTER STUDY
Authors: P Andreozzi, GD Nucci, M Devani, D Redaelli, M Schettino, D Iuliano, M Gagliardi, A Maurano, ME Bottiglieri, G Paspatis, M Dinelli, G Manes
Journal: Endoscopy (2020)

Aims Common bile duct stones (CBDS) can migrate spontaneously through the duodenal papilla. ERCP for small CBDS may be thus unnecessary and is likely to carry a significant rate of complications. We aim at retrospectively evaluating the rate of spontaneous stone passage in patients with an imaging diagnosis of CBDS.
Failure of High Dose 5-Iodo-2′-Deoxyuridine in the Therapy of Herpes Simplex Virus Encephalitis
Journal: New England Journal of Medicine (1975)

Two placebo-controlled double-blind studies were initiated to evaluate the therapeutic efficacy of 5-iodo-2-deoxyuridine (idoxuridine) in biopsy-provedcases of herpes simplex virus encephalitis. Twelve patients who on clinical grounds were thought to have herepes simplex virus encephalitis underwent brain biopsy; six of these patients were proved to have this disease, three were considered probable cases,and three were considered doubtful. The patients with proved or probably herpes simplex virus encephalitis were treated with parenteral idoxuridine (or placebo) at a dose of 100 mg per kiogram per day for five days. The occurrence of unacceptable myelosupperssion and the failure of idoxuridine therapy to prevent death led to the premature termination of both studies.
NODAL RECURRENCE TREATED WITH ENDOSCOPIC ULTRASOUND-GUIDED RADIOFREQUENCY ABLATION
Authors: RB Criado, AM Moretón, EG De Castro, BAM Da Silva, FS Santamarta, MC Luengo, MC Román, JS Fernández, SM Antolín, IP Herrero, FR Medina, JB Laguna, AG Pérez Millán
Journal: Endoscopy (2020)

Aims EUS-guided ablation procedures are emerging as a minimally invasive therapeutic alternative for locally advanced pancreatic cancer, pancreatic neuroendocrine tumors and pancreatic cystic lesions. This is a safe and technically easy procedure with few complications. In an animal model also demonstrated successful ablation of lymphatic nodes.
DOUBLE-CLIP TRACTION ESD FOR RECURRENT ADENOMA
Authors: J Jacques, J Albouys, S Geyl, A Charissoux, A Guyot, R Legros, J Rivory, M Pioche
Journal: Endoscopy (2020)

We report a case of ESD of a 15-mm recurrent adenoma of the colon, following 4-cm piecemeal EMR. The submucosa was injected without elevation of the lesion. Mucosa was incised using a Dual Knife J remote from the lesion, to identify the submucosal plane. Our previously reported double-clip traction-ESD strategy was carried out on the rectal part of the lesion, with good exposition of the submucosa and fibrotic area. Good exposure allowed for rapid and safe complete R0 ESD of a 25-mm adenoma in 10 min. DCT-ESD is efficient with a high success rate for endoscopic resection of recurrent adenomas.
ENDOSCOPIC CHARACTERISTICS OF GORHAM-STOUT SYNDROME
Authors: AMA García, CMA García, JCV Poza, ÁP Díaz, IR Ruiz, K Mönkemüller, MA Martínez
Journal: Endoscopy (2020)

The syndrome is characterized by a massive generalized osteolisis, which is rapidly progressive. Interestingly, there is also a proliferation of vasculature lymphatic and vascular structures in various parts of the body.Gorham-Stout is also known as evanescent bone syndrome.
RECURRENT SEPSIS DUE TO CIANOCHRILATE INJECTION INTO SUBCARDIAL VARICES. ENDOSCOPIC CURATIVE TREATMENT
Authors: EB Castro, AM Fernández López, S Alonso Lorenzo, M Gómez Rivas, AG Gómez, AG Ramírez, L López Rosés
Journal: Endoscopy (2020)

A 60 years old man with HCV cirrhosis suffered variceal subcardial bleeding and was treated with cianochrilate injection. During the following year he presented multiple bacteremias and sepsis without a clear origin even with a full body CT, MRI and SPECT. We performed an upper endoscopy and USE which showed an hypoechoic structure into the previous injection point compatible with acummulated cianochrilate. Then by using a needle-knife sphincterotome we cut this area and using a forceps we extracted all the acummulated cianochrilate. After this, the outcome was favorable without any more bacteremias, allowing to submit the patient to liver transplantation.
PLEINVUE IN THE CLINICAL PRACTICE OF A PRIVATE HOSPITAL IN NORTHERN MADRID: INITIAL RESULTS OF COLONOSCOPIC PREPARATION
Authors: E Pérez-Arellano, I Ródriguez García, AB Galera, E De La Morena Madrigal
Journal: Endoscopy (2020)

Aims To evaluate the effectiveness, tolerability and safety of IL PEG + ASCORBIC ACID (PLEINVUE) in a real-life setting.
GASTRIC CANCER OCCURS AT 3-YEARS ENDOSCOPIC SURVEILLANCE IN LOW RISK ATROPHIC GASTRITIS PATIENTS
Authors: G Esposito, M Cazzato, F Falangone, E Di Giulio, E Pilozzi, B Annibale, E Lahner
Journal: Endoscopy (2020)

Aims Atrophic gastritis (AG) or intestinal metaplasia (IM) are at risk for development of pre- and neoplastic lesions. MAPS II guidelines recommend for patients with advanced stage of AG/IM, surveillance with high quality endoscopy every 3 years.
SAFETY ATTITUDES IN ENDOSCOPY: AN URBAN TERTIARY REFERRAL CENTRE VS. A RURAL SINGLE ROOM UNIT
Authors: CL Murphy, P Uppamuchikkal, M Murray, P Wieneke, J Sheridan
Journal: Endoscopy (2020)

Tab. 1 Results Table Urban vs Rural Endoscopy Units Domain Urban Rural (p Value) working conditions 73% 89.50% (0.01314) stress recognition 73.25% 88.88% (0.05118) perception of hospital management 56% 97.70% (< .00001)
Destruction of a distal hypoxia response element abolishes trans-activation of the PAG1 gene mediated by HIF-independent chromatin looping
Authors: A Schoerg, Platt Ssj., J Schoedel, Lindenmeyer, C D Cohen, K Schroedter, Mole, R H Wenger, D Hoogewijs
Journal: American Journal of Hematology (2015)
Mean platelet volume in patients with obstructive sleep apnea syndrome and its relationship with cardiovasculer diseases
Authors: Elif Kaya, Asiye Kanbay, Nuri Tutar, Hakan Buyukoglan, Fatma Sema Oymak, Inci Gulmez, Ramazan Demir
Journal: European Respiratory Journal (2011)

Obtructive Sleep Apnea Syndrome (OSAS) is an independent risk factor for the development of cardiovascular event and hypertension. Mean Platelet Volume (MPV); an indicator of platelet activation and aggregation which are closely related with cardiovascular diseases (CVD). We aimed to show the relationship between OSAS and MPV with CVD. The medical records of 205 subjects who were admitted for the sleep study were evaluated. OSAS was diagnosed by polysomnography if Apnea-Hypopnea Index (AHI) >5. MPV calculated from blood samples. According to AHI, individuals in whom AHI 30 group 4 (severe OSAS group). Of the subjects 137 (67%) were male, 68 (33%) were female and the mean age was 53.0±14.1years. There were 35 (17%), 20 (10.2%), 40 (20.4%) and 108 (52.6%) in group 1, 2, 3 and 4 respectively. There were significant differences in terms of coronary artery disease and hypertension between all groups (p
Platelet-rich plasma injection and becaplermin gel as effective dressing adjuvants for treating chronic nonhealing ulcers in patients with junctional epidermolysis bullosa
Authors: Saurabh Singh, Varun Rajagopal S, Navneet Kour, Meenakshi Rao, Raghavendra Rao
Journal: Journal of the American Academy of Dermatology (2020)
Ghrelin inhibits interleukin-6 production induced by cigarette smoke extract in the bronchial epithelial cells via NF-κB pathway
Authors: Ting Yang, Yongchun Shen, Xiaoou Li, Fuqiang Wen, Liuqun Jia, Chun Wan
Journal: European Respiratory Journal (2013)

Objectives:  The present study was designed to evaluate whether ghrelin inhibits the proinflammatory cytokine interleukin-6 (IL-6) productiion induced by cigarette smoke extract (CSE) in the human bronchial epithelial cell line (16-HBE) and which mechanism is related with this effect of ghrelin.   Methods:  16-HBE cells were preincubated with vehicle or ghrelin (0.1 to 1000 ng/mL) in a concentration-dependent manner and then CSE (0 to 16%) was added. The secretion and mRNA expressions of IL-6 was detected by ELISA and RT-PCR. The phosphorylation of IKKα/β/p65 protein and the degradation of inhibitory protein-κB (I-κB) in 16-HBE were examined by western blot analysis, and then detected the generation of reactive oxygen species (ROS) in 16-HBE by labeling pecific fluorescence probes DCFH-DA.   Results:  Cells treated with CSE (8%) exhibited significantly higher IL-6 production and secretion compared with cells treated with vehicle alone (P 0.05).   Conclusions:  Together, these results suggest that ghrelin inhibits CSE-induced IL-6 production in 16-HBE cells by targeting on NF-κB pathway, but not by scavenging intracellular ROS.
THE “TUNNEL + CLIP” STRATEGY, A SAFE TECHNIQUE THAT FACILITATES OESOPHAGEAL ENDOSCOPIC SUBMUCOSAL DISSECTION: A FRENCH BI-CENTRIC PROSPECTIVE OBSERVATIONAL STUDY
Authors: T Wallenhorst, J Jacques, R Legros, M Pioche, M Pagenault, D Sauterau
Journal: Endoscopy (2020)

Aims Endoscopic submucosal dissection (ESD) is the treatment of choice for superficial neoplasia of the oesophagus. ESD requires a high level of skill, being both technically challenging and time consuming. Therefore, ESD is often reserved for experts. A combination of the tunnel technique associated with clip + wire traction has been described as being able to optimize the performance of oesophageal ESD.
Saline-immersion therapeutic endoscopy (SITE) combined with endoscopic submucosal dissection (ESD) of a rare cause of intussusception: a giant Brunner gland adenoma
Authors: Nikolaos Lazaridis, Alberto Murino, Filippos Solonos, Eftychia Athanasiadou, Alice Podesta, Tomonori Yano, Edward J. Despott
Journal: Endoscopy (2020)

A 48-year-old woman was referred to our institution due to abdominal pain and an episode of melena. At esophagogastroduodenoscopy (EGD) an 60-mm pedunculated lesion (Paris 0-Ip) was identified. The lesion was arising from the duodenal aspect of the pyloric ring ([Fig. 1], [Fig. 2]) and prolapsing into D3. Computed tomography showed duodenal thickening with areas of fat tissue that could represent a lipoma or a liposarcoma. A scheduled therapeutic EGD was performed under general anesthesia with surgical backup on standby. The scope was retroflexed in the bulb to ensure direct visualization of the lesion’s stalk and saline-immersion therapeutic endoscopy (SITE)-facilitated endoscopic submucosal dissection (ESD) was performed ([Fig. 3], [Video 1]). After resection, tip-of-the-knife coagulation was applied prophylactically to cauterize any visible vessels. No intraprocedural or postprocedural complications occurred.