In AF, DOACs were linked to lower risk for clinical fracture at 17 months compared with warfarin
Authors: Andrew Dunn
Journal: Annals of Internal Medicine (2020)

ACP Journal Club17 March 2020In AF, DOACs were linked to lower risk for clinical fracture at 17 months compared with warfarinAndrew Dunn, MD, MPHAndrew Dunn, MD, MPHIcahn Mount Sinai School of Medicine, New York, New York, USA (A.D.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJ202003170-034 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationLutsey PL, Norby FL, Ensrud KE, et al. Association of anticoagulant therapy with risk of fracture among patients with atrial fibrillation. JAMA Intern Med. 2020;180:245-53. https://pubmed.ncbi.nlm.nih.gov/31764956Clinical Impact RatingsGIM/FP/GP: Cardiology: Public Health: References1 Kearon C, Akl EA, Ornelas J, et al. Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report. Chest. 2016;149:315-52. [PMID: 26867832] Google Scholar2 January CT, Wann LS, Calkins H, et al. 2019 AHA/ACC/HRS focused update of the 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation. J Am Coll Cardiol. 2019;74:104-32. [PMID: 30703431] Google Scholar3 López-López JA, Sterne JA, Thom HH, et al. Oral anticoagulants for prevention of stroke in atrial fibrillation: systematic review, network meta-analysis, and cost effectiveness analysis. BMJ. 2017;359:j5058. [PMID: 29183961] Google Scholar4 Namba S, Yamaoka-Tojo M, Hashikata T, et al. Long-term warfarin therapy and biomarkers for osteoporosis and atherosclerosis. BBA Clin. 2015;4:76-80. [PMID: 26674156] Google Scholar5 Fiordellisi W, White K, Schweizer M. A systematic review and meta-analysis of the association between vitamin K antagonist use and fracture. J Gen Int Med. 2019;34:304-11. [PMID: 30511289] Google Scholar6 Ordi-Ros J, Sáez-Comet L, Pérez-Conesa M, et al. Rivaroxaban versus vitamin K antagonist in antiphospholipid syndrome: a randomized noninferiority trial. Ann Intern Med. 2019;171:685-94. [PMID: 31610549] Google Scholar7 Eikelboom JW, Connolly SJ, Brueckmann M, et al. Dabigatran versus warfarin in patients with mechanical heart valves. N Engl J Med. 2013;369:1206-14. [PMID: 23991661] Google Scholar Author, Article, and Disclosure InformationAffiliations: Icahn Mount Sinai School of Medicine, New York, New York, USA (A.D.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M19-3040.This article was published at Annals.org on 3 March 2020. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoIn AF, DOACs were linked to lower risk for osteoporotic fractures at 2 years compared with VKAs Andrew Dunn Metrics 17 March 2020Volume 172, Issue 6Page: JC34KeywordsAnticoagulantsAtrial fibrillationDatabasesHeartInternational classification of diseases ninth revision clinical modificationProteinsSafetyValve replacementValvular diseasesVenous thromboembolism ePublished: 17 March 2020 Issue Published: 17 March 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...