tbuckley/cabot-search huggingface dataset:
Gastric Mucosal Hypertrophy Masquerading as Metastasis From Neuroendocrine Tumor of the Pancreas Detected on 68Ga-DOTANOC PET/CT
Authors: Dharmender Malik, Ramkumar Elumalai, Ritu Verma, Ethel Shangne Belho, Nikhil Seniaray, Harsh Mahajan
Journal: Clinical Nuclear Medicine (2019)

Abstract A 57-year-old man, on octreotide treatment for metastatic neuroendocrine tumor pancreas, was referred for whole-body 68 Ga-DOTANOC PET/CT scan to evaluate treatment response. PET/CT scan revealed DOTANOC-avid lesion in the head of the pancreas with multiple tracer-avid soft tissue lesions in the liver, bilateral adrenal glands, and periportal lymph nodes. In addition, diffuse intense DOTANOC-avid mural thickening with intraluminal polypoidal mass formation was noted within the stomach causing significant luminal compromise, histopathological examination of which turned out be hypertrophic hypersecretory gastropathy. This case highlights the possibility of overexpression of somatostatin receptors in gastric hypertrophy, which has been little explored in literature.
Small-Volume Tubes to Reduce Anemia and Transfusion (STRATUS): A Pragmatic Stepped Wedge Cluster Randomized Trial
Authors: Deborah M Siegal, Emilie Belley-Cote, Donald M. Arnold, Frederick D'Aragon, Hill Stephen, Shun Fu Lee, Tara Pinto, Bram Rochwerg, Stuart J. Connolly, Ryan Zarychanski, Mark Crowther
Journal: Blood (2019)
The Effect of the Soluble Guanylate Cyclase Stimulator Olinciguat on Renal Function and Biomarkers of Inflammation and Renal Injury in Sickle Cell Mice
Authors: Boris Tchernychev, Raghunath Ramanarasimhaiah, Guang Liu, Katherine Hall, Regina Margaret Graul, Jaime Masferrer
Journal: Blood (2019)
Cross-Sectional Comparative Study of PK-Guided Switch between Standard Half-Life and Extended Half-Life Factor VIII Products
Authors: Juan Eduardo Megias, Santiago Bonanad Boix, María Fernanda Martínez García, Rubén Berrueco, Maria Eva Mingot-Castellano, Manuel Rodríguez López, Mariana Canaro, José Mateo Arranz, Itziar Larrodé Leciñena, Saturnino Haya, Amparo Santamaria Ortiz, Carmen Albo, Montserrat Mesegué Medea, Antonio Palomero-Massanet, Noelia Vilalta Seto, José Manuel Calvo Villas, Ana R Cid, Gustavo Robayo, José Luis Poveda Andrés, Guillermo F. Sanz, Alfonso Iorio
Journal: Blood (2019)
Final Results of Phase 1/1b Study of Tenalisib, Dual PI3K δ/γ Inhibitor in Patients with Relapsed/Refractory T-Cell Lymphoma
Authors: Swaminathan P. Iyer, Brad M. Haverkos, Jasmine Zain, Radhakrishnan Ramchandren, Mary Jo Lechowicz, Sumana Devata, Neil Korman, Lauren C. Pinter-Brown, Kasi Viswanath Routhu, Prajak Barde, Ajit Mohanchandran Nair, Auris Huen
Journal: Blood (2019)
QOLP-36. THE IMPORTANCE OF SLEEP DISTURBANCE IN PRIMARY BRAIN TUMOR (PBT) PATIENTS: CLINICAL CHARACTERISTICS &amp; CO-OCCURRENCE WITH TUMOR-RELATED &amp; PSYCHOLOGICAL SYMPTOMS
Authors: Amanda King, Dorela Shuboni-Mulligan, Elizabeth Vera, Sonja Crandon, Orwa Aboud, Ramya Antony, Lisa Boris, Christine Bryla, Eric Burton, Christine Cordova, Carrie Gartland, Ewa Grajkowska, Marta Penas-Prado, Jennifer Reyes, Nicole Leggiero, Christine Siegel, Brett Theeler, Kathleen Wall, Jing Wu, Mark Gilbert, Terri Armstrong
Journal: Neuro-Oncology (2019)

Abstract Sleep disturbance (SD) is a common symptom reported by PBT patients and research has demonstrated a link between sleep and stress circadian pathways. SD can impact perceived severity of other symptoms and development of psychopathology. This study explored the prevalence of moderate-severe SD in PBT patients, identifying associated clinical characteristics and co-occurrence with other tumor-related and psychological symptoms. Demographic, clinical characteristics, MDASI-Brain Tumor, and PROMIS Depression and Anxiety Short-Forms were collected at study entry. Descriptive statistics, Chi-square tests, and independent t-tests were used to report results. The sample included 424 patients (58% male, 81% Caucasian) with a median age of 49 years (range 18–81) and 58% with high-grade gliomas. Most had received treatment with surgery, radiation or chemotherapy prior to study entry, with 44% reporting a past recurrence. Moderate-severe SD (³ 5 on a 0–10 scale) was reported in 19% of patients and was associated with younger age (mean difference = 5 years), poor KPS (OR 2.2), current steroid use (OR 2.4), and tumor progression on MRI (OR 2). Those with moderate-severe SD had a higher overall symptom burden (mean difference = 2.3) and reported more moderate-severe symptoms (8 vs. 2). Patients reporting moderate-severe SD also reported higher severity in affective and cognitive symptom domains and mood-interference, with fatigue (72%), drowsiness (59%), and distress (56%) the most frequently co-occurring symptoms. Patients with moderate-severe SD also had increased prevalence of moderate-severe anxiety (32%) and depression (23%), compared to 10% in those without SD. PBT patients with moderate-severe SD are more symptomatic and have higher incidence of mood disturbance, suggesting a key role for sleep in the development of tumor-related and psychological symptoms. Future work delineating specific pathways involving sleep disturbance and co-occurring symptoms will be foundational for designing targeted sleep interventions to improve symptom burden and quality of life.
Prognostic impact of sustained new-onset atrial fibrillation in critically ill patients
Authors: Takuo Yoshida, Shigehiko Uchino, Yusuke Sasabuchi, Yasuhiro Hagiwara, Tomonao Yoshida, Hiroshi Nashiki, Hajime Suzuki, Hiroshi Takahashi, Yuki Kishihara, Shinya Nagasaki, Tomoya Okazaki, Shinshu Katayama, Masaaki Sakuraya, Takayuki Ogura, Satoki Inoue, Masatoshi Uchida, Yuka Osaki, Akira Kuriyama, Hiromasa Irie, Michihito Kyo, Nozomu Shima, Junichi Saito, Izumi Nakayama, Naruhiro Jingushi, Kei Nishiyama, Takahiro Masuda, Yasuyuki Tsujita, Masatoshi Okumura, Haruka Inoue, Yoshitaka Aoki, Takashiro Kondo, Isao Nagata, Takashi Igarashi, Nobuyuki Saito, Masato Nakasone
Journal: Intensive Care Medicine (2019)
Bullous Lesions in Acute Barbiturate Intoxication
Authors: G. W. Beveridge, A. A. H. Lawson
Journal: BMJ (1965)

MBicfJORLAmong 18 explorations there were four in which incision of the periosteum revealed no pus, but drilling of the underlying bone released pus under tension Moreover, in two other cases incision of the periosteum over the point of maximum tenderness proved negative, but on further separation of the periosteum a gush of pus was released from the opposite side of the bone.In both these examples, representing one-third of the cases, aspiration wopld have been negative and failed to relieve tension, which must, however marginally, have prejudiced the vascularity of the cortex.I feel, therefore, that, although aspiration is clearly often adequate, it is not always the optimal treatment and, when negative, must be followed by exploration to exclude the possibility of inaccessible pus.In all the 17 cases quoted satisfactory healing of the bones followed without sequestrum formation.The only significant com- plication was the development in one.case of delayed avascular necrosis of the femoral head twelve months after an osteitis of the femoral neck.
"Unjustified" Use of d - Tubo - curarine Chloride
Authors: P. Malpas
Journal: BMJ (1947)

Sudden Death after Intravenous Injection of Mercurial Diuretic SIR,-A.G. Oettle's case of sudden death after intravenous "neptal " (Oct.4, p. 530) prompts me to a few remarks.Such disasters cannot always be avoided-e.g., if they happen after the first injection to a patient, where there is no reason to expect untoward reactions.Such cases, fortunately, are extremely rare.More often, faulty.choice of the case and an overdose are the cause of toxic reactions.The following rules should help to restrict fatal or toxic reactions.Mercury administration must never be given in excess of the excretory power of the kidneys.Low con- centrating power and poor response to a previous injection are warning signals.The minimal injection-free interval should be three days, except in acute emergencies.Digitalis, strophanthin, urea, and ammonium chloride help to make this possible.The
A Phase 2, Open-Label, Multicenter Study Evaluating the Safety and Efficacy of Axicabtagene Ciloleucel in Combination with Either Rituximab or Lenalidomide in Patients with Refractory Large B-Cell Lymphoma (ZUMA-14)
Authors: Sattva S Neelapu, Mohamed A Kharfan-Dabaja, Olalekan O. Oluwole, Patel Krish, Ran Reshef, Peter A. Riedell, Parveen Shiraz, Patrick J. Stiff, Jose Villasboas, Lovely Goyal, Jun Kawashima, Francesca Milletti, Edward Oliva, Jennifer Sun, Javier Munoz
Journal: Blood (2019)
In Utero Diagnosis of Hemoglobinopathies
Authors: Henry Chang, John C. Hobbins, Gabriel Cividalli, Fredric D. Frigoletto, Maurice J. Mahoney, Yuet Wai Kan, David G. Nathan
Journal: New England Journal of Medicine (1974)

PREVIOUS reports have established the feasibility of measurement of the relative rates of γ, β and α globin-chain synthesis by fetal erythrocytes obtained from aborted concepti after hysterotomy.1 2 3 To extend these earlier efforts toward a practical technic for the prenatal diagnosis of hemoglobinopathy, a method must be devised to obtain fetal blood in situ without harm either to the mother or to the fetus. This paper and that by Hobbins and Mahoney4 report a step in that direction — the direct aspiration of fetal blood from the placenta followed by radiochromatographic analysis of globin-chain synthesis in the sample.MethodsPregnant . . .
Hematopoietic Engraftment of Fanconi Anemia Patients through 3 Years after Gene Therapy
Authors: Paula Rio, Susana Navarro, Rebeca Sanchez-Dominguez, Jose C Segovia, Wei Wang, Eva Merino, Rosa M Yañez, Jose Antonio Casado, Yari A. Gimenez, Francisco J Roman-Rodriguez, Omaira Alberquilla, Eva Galvez, Raquel Hladun, Jordi Barquinero, Anne Galy, Nagore García de Andoín, Ricardo López, Albert Catalá, Marina Cavazzana, Francois Lefrere, Thierry Leblanc, Jonathan D Schwartz, Roser Pujol, Jordi Surrallés, Jean Soulier, Manfred Schmidt, Cristina Díaz de Heredia, Julian Sevilla, Juan A. Bueren
Journal: Blood (2019)
F-Deletion Non-Integrating Measles Virus Vector: A Promising Tool for T-Cell Engineering and Naive iPSCs Generation
Authors: Jiyuan Liao, Yasushi Soda, Ai Sugawara, Yoshie Miura, Takafumi Hiramoto, Maino Tahara, Yuto Takishima, Shohei Miyamoto, Makoto Takeda, Kenzaburo Tani
Journal: Blood (2019)
Supravalvular Aortic Stenosis
Authors: J. C. P. WILLIAMS, B. G. BARRATT-BOYES, J. B. LOWE
Journal: Circulation (1961)

Facial resemblance to a patient in whom supravalvular aortic stenosis was discovered and successfully relieved at operation has led to the correct diagnosis of supravalvular stenosis in three other patients. All four patients are mentally subnormal. The presence of supravalvular aortic stenosis in mentally retarded patients with the unusual facial features here detailed may constitute a syndrome that has not previously been described.
Home or Away from Home: A Multi-Institution Study Comparing Medical Outcomes, Patient Perspectives, and Health-Related Quality of Life for Outpatient Versus Inpatient Management after Chemotherapy for Pediatric Acute Myeloid Leukemia
Authors: Kelly D Getz, Yimei Li, Julia E Szymczak, Catherine Aftandilian, Staci D. Arnold, Kira O Bona, Emi Caywood, Anderson B. Collier, Maria Monica Monica Gramatges, Meret Henry, Craig Lotterman, Kelly Maloney, Amir Mian, Rajen Mody, Elizabeth A. Raetz, Jeffrey Rubnitz, Anupam Verma, Naomi Winick, Jennifer J. Wilkes, Jennifer C. Yu, Brian T. Fisher, Richard Aplenc
Journal: Blood (2019)
RARE-20. ANALYSIS OF CLINICAL FEATURES ON DEATH FROM INTRACRANIAL GERM CELL TUMORS (GCTS): ARETROSPECTIVE COHORT STUDY
Authors: Linbo Cai, Juan Li, Mingyao Lai, Cheng Zhou, Qingjun Hu, Zhaoming Zhou, Lichao Wang
Journal: Neuro-Oncology (2019)

Abstract OBJECTIVES The present study aimed to investigate the clinical features associating with intracranial germ cell tumors(GCTs) of poor prognosis. METHODS We retrospectively analyzed the death data cohort based on 47 patients (30 males and 17 females) who had been diagnosed with GCTs between 2005 and 2018 in our hospital. The median age at initial diagnosis was 16 years (range, 3¬60 years). Among those, 18 patients were germinoma and 29 patients were non¬seminomatous germ-cell tumors (NGGCTs). RESULTS According to Kaplan-Meier survival analysis, children aged ≤ 10 years were observed with a very short survival compared to patients aged &gt; 10 years, indicating a 5-year survival rate of 0 and 50%, respectively (P &lt; 0.001). To be more specific, disseminated tumors were found to be the most prominent factor for prognosis in children aged ≤ 10 years: the 1-year survival for MR positive versus MR negative of disseminated tumors were 0 and 62.5%, respectively (P &lt; 0.05). On the other hand, the pre¬treatment serum alpha-fetoprotein (AFP) level was found to be an important surrogate for prognosis. In the subgroup of patients &gt; 10 years, the 5-year survival for AFP &gt; 1.5ng/ml was 25%, in comparison to 66% for AFP ≤ 1.5ng/ml (P &lt; 0.05). Further, solid survival advantages were found in patients received stereotactic radiosurgery (SRS) compared to none. The 5¬year survival for SRS versus non-SRS patients were 62% and 29%, respectively (P &lt; 0.05). CONCLUSION Our data highlights a number of critical factors that may facilitate the prognosis stratifications of GCTs. What’s more, neither the locations of the primary tumors nor the numbers of lesions are associated with the prognosis of GCTs. These results warrant further investigation via randomized prospective studies.
Low-Density Lipoprotein-Reactive T Cells Regulate Plasma Cholesterol Levels and Development of Atherosclerosis in Humanized Hypercholesterolemic Mice
Authors: Anton Gisterå, Maria L. Klement, Konstantinos A. Polyzos, Reiner K.W. Mailer, Amanda Duhlin, Mikael C.I. Karlsson, Daniel F.J. Ketelhuth, Göran K. Hansson
Journal: Circulation (2018)

Background: Atherosclerotic cardiovascular disease is a chronic inflammatory process initiated when cholesterol-carrying low-density lipoprotein (LDL) is retained in the arterial wall. CD4 + T cells, some of which recognize peptide components of LDL as antigen, are recruited to the forming lesion, resulting in T-cell activation. Although these T cells are thought to be proatherogenic, LDL immunization reduces disease in experimental animals. These seemingly contradictory findings have hampered the development of immune-based cardiovascular therapy. The present study was designed to clarify how activation of LDL-reactive T cells impacts on metabolism and vascular pathobiology. Methods: We have developed a T-cell receptor–transgenic mouse model to characterize the effects of immune reactions against LDL. Through adoptive cell transfers and cross-breeding to hypercholesterolemic mice expressing the antigenic human LDL protein apolipoprotein B-100, we evaluate the effects on atherosclerosis. Results: A subpopulation of LDL-reactive T cells survived clonal selection in the thymus, developed into T follicular helper cells in lymphoid tissues on antigen recognition, and promoted B-cell activation. This led to production of anti-LDL immunoglobulin G antibodies that enhanced LDL clearance through immune complex formation. Furthermore, the cellular immune response to LDL was associated with increased cholesterol excretion in feces and with reduced vascular inflammation. Conclusions: These data show that anti-LDL immunoreactivity evokes 3 atheroprotective mechanisms: antibody-dependent LDL clearance, increased cholesterol excretion, and reduced vascular inflammation.
A Prospective Observational Study of Clinico-Pathological Features, Prognostic Factors and Treatment Response to Primary Therapy in Multiple Myeloma at a Tertiary Care Centre
Authors: Saurabh Mishra, Ashok K Vaid, Nitin Sood, Manorama Bhargava, Bhuvan Chugh, Roshan Dixit, Amrita Ramaswami, Devender Sharma
Journal: Blood (2019)
ANTI-PD-1 Treatment in a Family with Constitutional Mismatch Repair Deficiency Syndrome with Multiple Cancers from Turkey. Is Cancer Immunoprevention with Checkpoint Inhibitors HAS a Role in CASES with Homozygous Mutationis
Authors: Emel Unal, Derya Ozyoruk, Nurdan Tacyildiz, Ferda Pi̇narli̇, A Erdogan, S Hanalioglu, Arzu Erdem, Meral Beksac
Journal: Blood (2019)
Optimal Cycles of Bendamustine-Plus Rituximab Therapy for Indolent B Cell Lymphoma
Authors: Kazuhiro Toyama, Toshiaki Takezaki, Akira Honda, Yasunori Kogure, Akira Chiba, Fumihiko Nakamura, Kumi Nakazaki, Mineo Kurokawa
Journal: Blood (2019)
Improving risk prediction in heart failure using machine learning
Authors: Eric D. Adler, Adriaan A. Voors, Liviu Klein, Fima Macheret, Oscar O. Braun, Marcus A. Urey, Wenhong Zhu, Iziah Sama, Matevz Tadel, Claudio Campagnari, Barry Greenberg, Avi Yagil
Journal: European Journal of Heart Failure (2019)
Immune Tolerance Induction (ITI) in Paediatric and Adult Patients with Haemophilia a (HA) and High-Titre (HT) Factor VIII (FVIII) Inhibitor - Real Life Data
Authors: Magdalena Katarzyna Letowska, Krystyna Zawilska, Anna Klukowska, Krzysztof Chojnowski, Joanna Zdziarska, Ewa Stefanska-Windyga, Jerzy Windyga
Journal: Blood (2019)
A Phase 2 Study of TAK-659, an Investigational Reversible Dual SYK/FLT3 Inhibitor, in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma
Authors: Tycel J. Phillips, Gilles Salles, Daniel J. Landsburg, Giuseppe Gritti, Krish Patel, Herve Tilly, Catherine Thieblemont, William Townsend, Silvia Ferrari, Kate F. Stumpo, Shilpi Katyayan, Cheryl Li, Harry Miao, Igor Proscurshim, Ajay K. Gopal
Journal: Blood (2019)
Improved Progression-Free Survival with Minimal Toxicity after Allogeneic Hematopoietic Stem Cell Transplantation in Older Patients with Hematological Malignancy
Authors: Betul Oran, Saliba M. Rima, Borje S Andersson, Marcos J de Lima, Uday R. Popat, Issa F. Khouri, Partow Kebriaei, Qaiser Bashir, Sairah Ahmed, Elizabeth J Shpall, Richard E. Champlin, Gabriela Rondon
Journal: Blood (2014)
A Fully Automated Measurement of Total Metabolic Tumor Burden in Diffuse Large B-Cell Lymphoma and Follicular Lymphoma
Authors: Skander Jemaa, Jill Fredrickson, Alexandre Coimbra, Richard AD Carano, Tarec Christoffer C. El-Galaly, Andrea Knapp, Tina G Nielsen, Deniz Sahin, Thomas Bengtsson, Alex de Crespigny
Journal: Blood (2019)
PDTM-13. A NOVEL DIFFUSE MIDLINE GLIOMA MODEL INITIATED IN OLIG2-EXPRESSING PROGENITORS OF THE NEONATAL BRAIN
Authors: Yosuke Shimazu, Agila Somasundaram, Daniel Brat, Oren Becher
Journal: Neuro-Oncology (2019)

Abstract Diffuse intrinsic pontine glioma (DIPG) is an incurable brain tumor that arises in the pons of children. Recent studies using single cell RNA-seq and enhancer analysis of DIPG tumor cells, together with analysis of the developing human pons, strongly suggest that an oligodendrocyte progenitor cell is the most likely cell-of-origin for DIPG. Here we describe a novel mouse model by expressing PDGF-B, with H3.3K27M or H3.3 wild-type in Olig2-expressing progenitors via injection into the 4th ventricle using Olig2-tva-cre;p53fl/fl mice. H3.3K27M tumors have high rate of Ki-67, Sox2, and Olig2 positivity and show a higher rate of leptomeningeal dissemination than H3.3 wild-type tumors (95.2％ vs 68.8%, p=0.0303) and mice harboring H3.3K27M tumors demonstrate a significantly shorter survival period than those harboring H3.3 wild-type tumors (31 days vs. 37 days, p=0.0473). While there is not any difference in survival between mice harboring PDGF-B; p53 wild-type; H3.3K27M tumors and those harboring PDGF-B; p53 wild-type; H3.3 wild-type tumors at the 6-month endpoint, we found that H3.3K27M tumors show a higher rate of high-grade glioma than H3.3 wild-type tumors (100% vs. 41.7%, p=0.0017). RNA-seq analysis identified 25 significantly differentially expressed genes with 23 upregulated and 2 downregulated genes in the PDGF-B; p53 null; H3.3K27M tumors compared with the H3.3 wild-type tumors. Phox2b, which is the most upregulated gene in the PDGF-B; p53 null; H3.3K27M tumors, was validated by qRT-PCR and expressed only in brainstem tumors and not expressed in tumors located in any other areas. IHC with Phox2b also revealed positivity in PDGF-B; p53 null; H3.3K27M tumors located only in the brainstem. Ongoing work includes validation of other significant differentially expressed genes as well as elucidation of their role in K27M-mediated gliomagenesis.
QOLP-21. LONG-TERM FOLLOW-UP OF GERM CELL TUMOR SURVIVORS
Authors: Tomoo Matsutani, Kentarou Horiguchi, Siro Ikegami, Seiichiro Hirono, Hisayuki Murai, Naokatsu Saeki, Yasuo Iwadate
Journal: Neuro-Oncology (2019)

Abstract Germ cell tumor (GCT) is a juvenile tumor, completely cured by adequate treatments, including radiation therapy and chemotherapy. However, survivors require continuous medical treatment mostly due to hypopituitarism, and several issues could be observed during follow-up. In the present report, we analyzed medical records of long-term GCT survivors, retrospectively, and make the issues clear. Of ninety-three, 82 GCT patients with several medical and social information are included in the analysis. Median follow-up time is 11.95 years, and 47 patients followed more than ten years. Fifteen deaths are recorded, and 8 are tumor-progression, and 7 are treatment-related long-term events, including four subsequent gliomas, one cerebral vascular disease, one renal cancer, and one sudden death. Seven survivors developed subsequent malignancy, and all lived more than 19 years and received more than 50Gy of irradiation. The overall survival rate is gradually decreasing more than ten years follow-up, such as 10-, 15- and 25-years survival are 92.3, 87.7 and 73.3%, respectively. Long-term follow-up also clarified several social issues. Forty-two of 50 adult survivors had a job after the treatments, but only thirty-four (70.8%) are still working. Of note, only nine (18.8% of adults) survivors got married. All four women require any hormone replacement, while only one of 4 men requires the replacement. Long-term follow-up of GCT survivors revealed subsequent malignancy and social problems. Recent attempt to decrease radiation dose and to give adequate hormone replacement might overcome these problems. Clinicians still observed GCT patients closely.
Left Ventricular Volumes, Mass and Function Normalized to the Body Surface Area, Age and Gender From CMR in a Large Cohort of Well-Treated Thalassemia Major Patients without Myocardial Iron Overload
Authors: Antonella Meloni, Giovanni Aquaro, Pierluigi Festa, Francesco Gagliardotto, Angelo Zuccarelli, Calogera Gerardi, Michele Santodirocco, Maria Antonietta Romeo, Maria Rita Gamberini, Maria Paola Smacchia, Giovanni Palazzi, Elisabetta Chiodi, Lucia De Franceschi, Vincenzo Positano, Massimo Lombardi, Alessia Pepe
Journal: Blood (2011)