tbuckley/cabot-search huggingface dataset:
Patients and Physicians in the Era of Modern Cancer Care
Authors: George W. Sledge
Journal: JAMA (2019)

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Anal adenocarcinoma: Treatment outcomes and trends in a rare disease entity.
Authors: Richard White, Shaakir Hasan, Moses Raj, Dulabh K. Monga, Gene Grant Finley, Alexander V. Kirichenko, James McCormick, Rodney E Wegner
Journal: Journal of Clinical Oncology (2019)

538 Background: Primary Adenocarcinoma of the rectum is a rare disease with a poor prognosis and thus tends to have a more aggressive treatment algorithm, typically involving a surgical approach. Prior to 2001, a few retrospective studies outlined improved outcomes with the incorporation of surgery with chemoradiation. However, since the publication of these studies, advancement in radiotherapy modalities and imaging have left the question of improved outcomes while reserving surgery for salvage. We conducted this NCDB-driven, retrospective study to analyze treatment trends and outcomes in the current time from 2004-2015 with respect to chemoradiation and surgery. Methods: We queried the NCDB for with AJCC stage 1-3 anal adenocarcinoma diagnosed between 2004-2015. Propensity score-matched multivariable cox regression analysis determined the association of incorporation of surgery into the definitive management of anal adenocarcinoma on survival. Results: Of the 1729 patients eligible patients in this study, 1028 were treated with surgery as up front management and 701 had definitive chemoradiation. Median overall survival for all patients was 55 months with a 5 year survival rate of 55%. Patients treated without surgery had worse overall survival, median survival of 45 months compared to 87 months (p &lt; .0001) with 5 year survivals of 42% and 55% in favor of incorporation of surgery. Analysis across patients treated with surgery alone, surgery followed by adjuvant chemoradiation, neoadjuvant chemoradiation followed by surgery, and chemoradiation alone had median survival rates of 78, 83, 92, and 46 months, respectively (p &lt; 0.0001). Propensity score adjusted multivariable analysis identified older age, grade 3, high comorbidity score, and lack of surgery as predictive of worse outcome. Conclusions: The results of the NCDB analysis indicate improved overall survival with the incorporation of surgery into the initial management of anal adenocarcinoma when compared to chemoradiation alone, despite the omission of surgery in up to 50% of the cases logged. Our results corroborate earlier studies published prior for surgery to be included in the definitive management of anal adenocarcinoma.
Cryptogenic multifocal ulcerous stenosing enteritis diagnosed with single-balloon enteroscopy
Authors: Yi-Ning Sun, Xiu-Li Zuo, Xiao Wang, Tian Ma, Zhen Li, Yan-Qing Li
Journal: Endoscopy (2019)

A 28-year-old woman had suffered from 6 years of chronic anemia symptoms and 4 years of repeated bouts of incomplete small-intestine obstruction with unclear cause. A retained video capsule endoscopy (VCE) 15 months previously had shown multiple circular ulcers in the small intestine. She had no history of previous medication usage, including nonsteroidal anti-inflammatory drugs (NSAIDs). Laboratory tests showed iron deficiency anemia (hemoglobin of 65 g/L), slight hypoalbuminemia (36.6 g/L), and positive occult blood in her stool, while inflammatory markers, immunologic function, and autoantibodies were all within their normal range. Tuberculosis and viral infection were also excluded. Repeated gastrointestinal (GI) endoscopy showed no remarkable findings. Computed tomography enterography (CTE) confirmed strictures manifested within the thickened small bowel and normal mesenteric vasculature ([Fig. 1]).
Surfactant Protein D (SP-D) Inhibits Neutrophil Extracellular DNA Trap Formation: Effects of S-nitrosylation
Authors: Shida Yousefi, Wenxiu Qu, Cameron H. Flayer, Darko Stojkov, Nina Germic, Salome Aeschlimann, Moyar Qing Ge, Hans-Uwe Simon, Angela Haczku
Journal: Journal of Allergy and Clinical Immunology (2019)
Hepatic PPARα is critical in the metabolic adaptation to sepsis
Authors: Réjane Paumelle, Joel T. Haas, Nathalie Hennuyer, Eric Baugé, Yann Deleye, Dieter Mesotten, Lies Langouche, Jonathan Vanhoutte, Céline Cudejko, Kristiaan Wouters, Sarah Anissa Hannou, Vanessa Legry, Steve Lancel, Fanny Lalloyer, Arnaud Polizzi, Sarra Smati, Pierre Gourdy, Emmanuelle Vallez, Emmanuel Bouchaert, Bruno Derudas, Hélène Dehondt, Céline Gheeraert, Sébastien Fleury, Anne Tailleux, Alexandra Montagner, Walter Wahli, Greet Van Den Berghe, Hervé Guillou, David Dombrowicz, Bart Staels
Journal: Journal of Hepatology (2019)
Human myofibroblastlike cells obtained by outgrowth are representative of the fibrogenic cells in the liver
Authors: S BLAZEJEWSKI
Journal: Hepatology (1995)

During human fibrogenesis, myofibroblastlike cells proliferate and are the main source of fibrosis components. We have used cultured myofibroblastlike cells obtained by outgrowth from explants of human liver to study the expression of extracellular matrix (ECM) components and matrix-metalloproteinase-2 (MMP-2). These cells contained types I, III, IV, and V procollagen messenger RNAs (mRNAs). They also expressed mRNAs for laminin B1 chain and for cellular and plasma fibronectin. The corresponding proteins were detected by immunocytochemistry. MMP-2 expression was shown by Northern blot and gelatin zymography. Because transforming growth factor β1 (TGFβ1) is considered an important mediator in liver fibrogenesis, we examined its effect on expression of ECM components by cultured human myofibroblastlike cells. TGFβ1 increased collagen mRNAs steady-state levels and total collagen secretion in the culture medium. It also increased fibronectin mRNA levels but had no effect on laminin mRNA or MMP-2 expression. In summary, cultured human myofibroblastlike cells express those ECM components that accumulate during hepatic fibrogenesis, indicating the usefulness of this model to study mechanisms of human liver fibrogenesis. In addition to the mitogenic effect of TGFβ1 on human myofibroblastlike cells, we now demonstrate its stimulation of ECM accumulation in these cells, thus emphasizing the central role of TGFβ1 and myofibroblastlike cells in the pathophysiology of human hepatic fibrosis. (Hepatology 1995; 22:788–797.)
Treatment of Patients with Hereditary Angioedema with Normal C1 Inhibitor: Evaluation of 295 Patients
Authors: Nyla T.M.L. Fragnan, Camila Veronez, Adriana Moreno, Luisa Karla P. Arruda, Rozana F. Goncalves, Solange Valle, Stephanie K.A. Almeida, Sergio D. Dortas, Maria Luiza Alonso, Eli Mansour, Faradiba Sarquis Serpa, Pedro Giavina-Bianchi, Priscila Takejima, Herberto J. Chong Neto, Nelson Augusto Rosario, Regis De Albuquerque Campos, Jane Silva, Eliana C. Toledo, Gabriela A.C. Dias, Natasha R. Ferraroni, Miguel Piccirilo, Marli S. Bernardes, Rosemeire N. Constantino-Silva, Joao B. Pesquero, Anete S. Grumach
Journal: Journal of Allergy and Clinical Immunology (2019)
The Induction of Autoimmune Arthritis and Sex Differences in Mice Impact the Lung Inflammatory Response to Repetitive Inhalant Organic Dust Extract Exposures
Authors: Kathryn Rentfro, Geoffrey Thiele, Katherine Janike, Amy Nelson, Michael J. Duryee, Bryant R. England, Debra J. Romberger, Joseph Carrington, Dong Wang, Benjamin Swanson, Lynell Klassen, Ted R. Mikuls, Jill A. Poole
Journal: Journal of Allergy and Clinical Immunology (2019)
Investigation into the α-Gal syndrome: Characteristics of a large cohort sensitized to galactose-α-1,3-galactose (α-Gal)
Authors: Jeffrey M. Wilson, Alexander J. Schuyler, Lisa Workman, Hayley James, Jonathon Posthumus, Emily C. McGowan, Scott P. Commins, Thomas A.E. Platts-Mills
Journal: Journal of Allergy and Clinical Immunology (2019)
A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells
Authors: Frédéric Van Gool, Michelle L.T. Nguyen, Maxwell R. Mumbach, Ansuman T. Satpathy, Wendy L. Rosenthal, Simone Giacometti, Duy T. Le, Weihong Liu, Todd M. Brusko, Mark S. Anderson, Alexander Y. Rudensky, Alexander Marson, Howard Y. Chang, Jeffrey A. Bluestone
Journal: Immunity (2019)
Misactivation of Hedgehog signaling causes inherited and sporadic cancers
Authors: David R. Raleigh, Jeremy F. Reiter
Journal: Journal of Clinical Investigation (2019)

The Hedgehog pathway is critical for the development of diverse organs. Misactivation of the Hedgehog pathway can cause developmental abnormalities and cancers, including medulloblastoma, the most common pediatric brain tumor, and basal cell carcinoma, the most common cancer in the United States. Here, we review how basic, translational, and clinical studies of the Hedgehog pathway have helped reveal how cells communicate, how intercellular communication controls development, how signaling goes awry to cause cancer, and how to use targeted molecular agents to treat both inherited and sporadic cancers.
Impact of Allergist-Facilitated Education on Public Healthcare Provider Confidence in Counseling about Early Peanut Introduction
Authors: Nicole J. Lee, Lianne Soller, Jennifer McConnell-Nzunga, Jennifer Scarr, Edmond S. Chan, Barbara Crocker, Jennifer Schneiderheit-Hsu, Kathy Triolet, Daniel Naiman, Susan Conley, Claire Heath, Kyla Hildebrand
Journal: Journal of Allergy and Clinical Immunology (2019)
Cervical screening: study “strongly supports” extending interval to five years
Authors: Zosia Kmietowicz
Journal: BMJ (2019)

Screening for high risk human papillomavirus (HPV) infection works well in practice and is more sensitive than cytology testing, a pilot study of more than half a million women has found.

The findings support a switch to HPV screening across England and provide reassurance that screening intervals could be safely extended to at least five years, without increasing the risk of potentially life threatening disease, say the researchers in The BMJ .1

At present, 2500 cases of cervical cancer are diagnosed each year in England, a quarter after a “normal” smear test result.

Clinical trials show that high risk HPV screening …
Acute Myeloid Leukemia (AML) with Somatic Mutations in PTPN11 Is Associated with Treatment Resistance and Poor Overall Survival
Authors: Justin D. Kaner, Nuria Mencia-Trinchant, Ariel Schaap, Gail J. Roboz, Sangmin Lee, Pinkal Desai, Michael Samuel, Spencer Krichevsky, Idongessit Udoyen, Duane C. Hassane, Monica L. Guzman, Ellen K. Ritchie
Journal: Blood (2018)
Nanoparticle-mediated intratumoral inhibition of miR-21 for improved survival in glioblastoma
Authors: Young-Eun Seo, Hee-Won Suh, Raman Bahal, Alexander Josowitz, Junwei Zhang, Eric Song, Jiajia Cui, Seth Noorbakhsh, Christopher Jackson, Tom Bu, Alexandra Piotrowski-Daspit, Ranjit Bindra, W. Mark Saltzman
Journal: Biomaterials (2019)
Abstract 15476: Genome-wide Transcriptome Study for Myocardial Infarction and Coronary Artery Calcification Using RNA-Seq
Authors: Xiaoling Zhang, Yoshiyuki Wakabayashi, Shih-Jen Hwang, Yanqin Yang, Daniel Levy, Andrew D Johnson, Jun Zhu, Christopher J O’Donnell
Journal: Circulation (2015)

Introduction: Coronary artery calcification (CAC) is a noninvasive measure of coronary atherosclerosis, which underlies most cases of myocardial infarction (MI). Genome-wide association (GWA) studies have identified common genetic variants associated with MI and CAC. However, the mechanisms underlying MI and CAC remain unclear. We sought to identify gene expression signatures of early MI and high CAC, and further investigate the underlying mechanisms between clinical MI and subclinical atherosclerosis in the Framingham Heart Study (FHS). Methods: We conducted a paired-end RNA sequencing on whole blood samples collected from 202 FHS participants (57 with early MI, 74 with high CAC without MI, and 71 control subjects free of elevated CAC levels and MI), with Illumina HiSeq 2000. After filtering non- expressed genes, for each of 12,063 protein-coding genes and 3,704 long intergenic non-coding RNAs (lincRNAs), we applied DESeq2 to identify genes differentially expressed in MI and high CAC, respectively, compared with the control group after adjusting for sex, batch and hidden confounders. Results: On average, 150 million paired-end reads were obtained for each sample. Among them, 71% of reads were mapped uniquely to the genome. At the false discovery rate (FDR) &lt;0.1, we found 71 coding genes and 9 lincRNAs differentially expressed between early MI and control. Pathway and gene ontology analysis further indicate that immune response, lipid metabolic process and interferon regulatory factor were enriched in these gene signatures. By contrast, only 3 coding genes are expressed differently between high CAC and controls at FDR&lt;0.1. APOD, encoding a component of high density lipoprotein, was expressed significantly lower in both early MI (FDR=0.007) and in high CAC (FDR=0.01) compared with controls, respectively, identifying a novel candidate for clinical and subclinical MI. Conclusion: We identified early MI expression signatures including protein-coding genes and lincRNAs, indicating the power of our extremely deep sequenced data to identify both coding genes and, in particular, lincRNA biomarkers expressed at levels much lower than coding genes. Our results suggest an important role for both protein-coding genes and lincRNAs in the pathogenesis of MI.
Prevalence and Risk Factors of Significant Fibrosis in Patients With Nonalcoholic Fatty Liver Without Steatohepatitis
Authors: Serena Pelusi, Annalisa Cespiati, Raffaela Rametta, Grazia Pennisi, Ville Mannisto, Chiara Rosso, Guido Baselli, Paola Dongiovanni, Anna Ludovica Fracanzani, Sara Badiali, Marco Maggioni, Antonio Craxi, Silvia Fargion, Daniele Prati, Valerio Nobili, Elisabetta Bugianesi, Stefano Romeo, Jussi Pihlajamaki, Salvatore Petta, Luca Valenti
Journal: Clinical Gastroenterology and Hepatology (2019)
Differential Co-release of Two Neurotransmitters from a Vesicle Fusion Pore in Mammalian Adrenal Chromaffin Cells
Authors: Quanfeng Zhang, Bin Liu, Qihui Wu, Bing Liu, Yinglin Li, Suhua Sun, Yuan Wang, Xi Wu, Zuying Chai, Xiaohan Jiang, Xiaoyao Liu, Meiqin Hu, Yeshi Wang, Yunting Yang, Li Wang, Xinjiang Kang, Yingfei Xiong, Yang Zhou, Xiaoke Chen, Lianghong Zheng, Bo Zhang, Changhe Wang, Feipeng Zhu, Zhuan Zhou
Journal: Neuron (2019)
Elevated expressions of stratum corneum Toll-like receptor 3 in atopic dermatitis lesions
Authors: Risa Tamagawa-Mineoka, Naomi Nakamura, Mayumi Ueta, Eiichi Konishi, Risa Yasuike, Koji Masuda, Hiroshi Matsunaka, Yumi Murakami, Emiko Yokosawa, Norito Katoh
Journal: Journal of Allergy and Clinical Immunology (2019)
Graft-Versus-Host Disease (GVHD) Prophylaxis with Post-Transplant Cyclophosphamide (PTCY) Induces a More Tolerant Immune Response after Allogeneic Hematopoietic Cell Transplantation (Allo-HCT) in Patients Previously Exposed to Nivolumab
Authors: Juan C Nieto, Elisa Roldan, Isabel Jiménez, Laura Fox, Júlia Carabia, Guillermo Orti, Lluis Puigdefàbregas, Laura Gallur, Gloria Iacoboni, Priyanka Raheja, Ana Perez, Olga Salamero, Carlos Palacio, David Valcarcel, Marta Crespo, Francesc Bosch, Pere Barba
Journal: Blood (2018)
Abstract 17629: Increased Gamma-glutamyltransferase Predicts All-cause Mortality Independently of Coronary Atherosclerosis
Authors: Jidong Sung, Su-Yeon Choi, Eun Ju Chun, Hae-Won Han, Hyuk-Jae Chang
Journal: Circulation (2016)

Introduction: Several studies have shown that increased gamma-glutamyltransferase (GGT) level is associated with higher cardiovascular mortality. While mechanism for this association is still uncertain, GGT have been shown to be associated with coronary atherosclerosis estimated by coronary artery calcium score (CACS), which is also a strong predictor of cardiovascular events. It is not known whether increased GGT predicts mortality independently of CACS. Hypothesis: Increased GGT is associated with all-cause mortality after adjustment for CACS and other risk factors. Methods: From multicenter registry of health screening cohort, 78188 subjects were included in the final dataset for analysis who were without history of ischemic heart disease or stroke and had results of both coronary calcium scoring and GGT. All-cause mortality data were obtained from national mortality registry. Results: Mean age of study subjects was 51 ± 10 years. Proportion of female was 31 %, 32% was non-drinkers, 17 % had habit of d...
Somatic TERT promoter Mutations in a Broad Spectrum of Telomeropathies
Authors: Fernanda Gutierrez-Rodrigues, Flávia S Donaires, André Pinto, Alana Vicente, Laura Dillon, Diego V Clé, Bárbara Santana, Maria del Pilar Fernandez Ibanez, Danielle M. Townsley, Sachiko Kajigaya, Christopher S. Hourigan, James N. Cooper, Rodrigo T. Calado, Neal S. Young
Journal: Blood (2018)
Physical activity tracking in correlation to conventional heart failure monitoring assessing improvements after transcatheter mitral and tricuspid valve repair
Authors: Thomas J. Stocker, Felicitas Scheck, Mathias Orban, Daniel Braun, Helene Hertell, Korbinian Lackermair, Simon Deseive, Michael Mehr, Martin Orban, Nicole Karam, Michael Nabauer, Steffen Massberg, Jörg Hausleiter
Journal: European Journal of Heart Failure (2019)
Wnt16 attenuates osteoarthritis progression through a PCP/JNK-mTORC1-PTHrP cascade
Authors: Wenxue Tong, Yelin Zeng, Dick Ho Kiu Chow, Wai Yeung, Jiankun Xu, Yujie Deng, Shihui Chen, Hui Zhao, Xiaoling Zhang, Kevin Kiwai Ho, Ling Qin, Kingston King-lun Mak
Journal: Annals of the Rheumatic Diseases (2019)

Objectives Wnt16 is implicated in bone fracture and bone mass accrual both in animals and humans. However, its functional roles and molecular mechanism in chondrocyte differentiation and osteoarthritis (OA) pathophysiology remain largely undefined. In this study, we analysed its mechanistic association and functional relationship in OA progression in chondrocyte lineage. Methods The role of Wnt16 during skeletal development was examined by Col2a1-Wnt16 transgenic mice and Wnt16 fl/fl ;Col2a1-Cre (Wnt16-cKO) mice. OA progression was assessed by micro-CT analysis and Osteoarthritis Research Society International score after anterior cruciate ligament transection (ACLT) surgery with Wnt16 manipulation by adenovirus intra-articular injection. The molecular mechanism was investigated in vitro using 3D chondrocyte pellet culture and biochemical analyses. Histological analysis was performed in mouse joints and human cartilage specimens. Results Wnt16 overexpression in chondrocytes in mice significantly inhibited chondrocyte hypertrophy during skeletal development. Wnt16 deficiency exaggerated OA progression, whereas intra-articular injection of Ad-Wnt16 markedly attenuated ACLT-induced OA. Cellular and molecular analyses showed that, instead of β-catenin and calcium pathways, Wnt16 activated the planar cell polarity (PCP) and JNK pathway by interacting mainly with AP2b1, and to a lesser extend Ror2 and CD146, and subsequently induced PTHrP expression through phosphor-Raptor mTORC1 pathway. Conclusions Our findings indicate that Wnt16 activates PCP/JNK and crosstalks with mTORC1-PTHrP pathway to inhibit chondrocyte hypertrophy. Our preclinical study suggests that Wnt16 may be a potential therapeutic target for OA treatment.
Henry G Kunkel and Rheumatoid Factor
Authors: Eng M Tan
Journal: Annals of the Rheumatic Diseases (2019)

Henry Kunkel was born in Brooklyn, New York in 1916. He died in 1983 at the early age of 67. He was an outstanding clinical scholar who had a deep passion for scientific facts. Almost all his scientific life was involved in biomedical research at the Rockefeller University in New York City. He had a laboratory on the third floor of Founder’s Hall (the first building at what was then Rockefeller Institute for Medical Research). His office was a spare, unpretentious room with a view of the East River in Upper Manhattan. To this room came many scientists the world over as well as many of his former fellows who came back to see the old master. He was especially glad to talk about experimental data and would drop what he was doing to talk about the deeper significance of their observations. His parting words would often be, ‘Come again’

Kunkel has received numerous accolades which could be exemplified in the following story. His research grant application was being reviewed at an NIH Study section meeting and a reviewer pointed out the lack of details concerning techniques and procedures, but …