THU0450 QUALITY OF LIFE OF PATIENTS WITH A COMBINATION OF SARCOPENIA AND OSTEOARTHRITIS OF LOWER EXTREMITY
Authors: Yuliya Safonova, Evgeniy Zotkin
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> In accordance with the updated recommendations of the EWGSOP (2018), sarcopenia is a muscle disease (muscle failure) rooted in adverse muscle changes that accrue across a lifetime [1]. Sarcopenia and osteoarthritis significantly affect the self-esteem quality of life which is associated with a decrease in muscle strength and muscle performance, falls, joint pain [2]. In 2015, the SarQoL® questionnaire (Sarcopenia and Quality of Life, www.sarqol.org) was developed, specific to patients with sarcopenia. Improvement of quality of life should be the priority of any interventions to prevent and treat osteoarthritis and sarcopenia in the ageing population [3]. <h3>Objectives</h3> Perform quality of life analysis in patients with osteoarthritis and sarcopenia. <h3>Methods</h3> Prospective study of 159 women, mean age 74 ± 13.3. Sarcopenia was diagnosed according to the algorithm proposed by the European Working Group on Sarcopenia in Older People (EWGSOP, 2010). Life quality assessment was performed using EQ-5D questionnaires and a specific questionnaire in patients with sarcopenia SarQoL. <h3>Results</h3> 31.45% of people with OA older than 65 years had sarcopenia. The results of the study showed a statistically significant decrease in overall health on the questionnaire EQ-5D in patients with sarcopenia compared with patients without sarcopenia (0.48 ± 0.22 points and 0.74 ± 0.27 points, respectively, p &lt;0.01) and no differences according to the EQ-VAS scale in the studied groups (p&gt; 0.05). The decrease in the general health status of EQ-5D in patients with OA sarcopenic compared with non-sarcopenic is associated with a restriction of the usual daily activities: in 70% (95% CI: 55.4-82.1) and 52.3% (95% CI: 42.5-61.9) respectively, (p &lt;0.01). In patients with OA, reduced global SarQoL in sarcopenic subjects compared to non-sarcopenic ones: 50,65±14,23 vs. 75,10±14,46, р&lt;0,001. Significantly lower scores for all domains were found in patients with OA sarcopenic compared with non-sarcopenic patients (р&lt;0.001). <h3>Conclusion</h3> In patients with OA sarcopenic, the quality of life is worse than that of non-sarcopenic due to a decrease in habitual daily activities, probably associated with low muscle strength. <h3>References</h3> [1] Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Guidelines. Sarcopenia: revised European consensus on definition and diagnosis on definition and diagnosis. Age and Ageing 2018; 0: 1–16. doi: 10.1093/ageing/afy169Milte R, Crotty M. Musculoskeletal health, frailty and functional decline. Best Pract Res Clin Rheumatol. 2014;28(3):395–410 [2] Beaudart С., Biver E., Bruyère O. et al. Assessment of Quality of Life in Musculo-Skeletal Health. Aging Clin Exp Res. 2018 May; 30(5): 413–418Hoops ML, Rosenblatt NJ, Hurt CP, Crenshaw J, Grabiner MD. Does lower extremity osteoarthritis exacerbate risk factors for falls in older adults? Womens Health (Lond Engl). 2012;8(6):685–96 [3] Beaudart C, Biver E, Reginster J-Y, et al. Development of a self-administrated quality of life questionnaire for sarcopenia in elderly subjects: the SarQoL. Age Ageing. 2015; 44 (6):960–6 <h3>Disclosure of Interests</h3> None declared