tbuckley/cabot-search huggingface dataset:
Association between Inflammatory Markers and Abnormal Neurological, Neurocognitive and Magnetic Resonance Imaging (MRI) Findings in Children with Sickle Cell Anemia in Uganda
Authors: Amelia Boehme, Adiba Ashrafi, Richard Idro, Paul Bangirana, Deogratias Munube, Robert Opoka, Philip Kasirye, Margaret T. Lee, Nancy S. Green, Mady Hornig
Journal: Blood (2019)
OP201: A Phase 1/2 Study of Melflufen and Dexamethasone in Patients with Immunoglobulin Light Chain (AL) Amyloidosis
Authors: Giovanni Palladini, Stefan O. Schönland, Suzanne Lentzsch, M. Teresa Cibeira, Roman Hajek, Arnaud Jaccard, Krzysztof Jamroziak, Eftathios Kastritis, Vaishali Sanchorawala, Fredrik H. Schjesvold, Ashutosh D Wechalekar, Sara Thuresson, Johan Harmenberg, Catriona Byrne, Giampaolo Merlini
Journal: Blood (2019)
Efficacy and Safety of Subcutaneous Prophylaxis with Concizumab in Patients with Severe Hemophilia a without Inhibitors: Results from the Phase 2 explorer5 Trial
Authors: Hermann Eichler, Pantep Angchaisuksiri, Jan Astermark, Gary Benson, Katarina Cepo, Pratima Chowdary, Ute Friedrich, Kaan Kavakli, Allison P Wheeler, Johannes Oldenburg
Journal: Blood (2019)
Staurosporine Induces Caspase-Dependent Proteolysis of MEF2D-Fusion Protein and Cell Death Selective to MEF2D-Fusion-Positive ALL Cells
Authors: Naoyuki Tange, Fumihiko Hayakawa, Takahiko Yasuda, Hideyuki Yamamoto, Daiki Hirano, Shinobu Tsuzuki, Hitoshi Kiyoi
Journal: Blood (2019)
No Impact of Donor's Age-Related Clonal Hematopoiesis (ARCH) Observed on Graft-Versus-Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation: Result from Bar-Coded Error Corrected Sequencing in 33 Gene Mutations on 372 Pairs of Donor and Recipient
Authors: Kyoung Ha Kim, Taehyung Kim, Jae-Sook Ahn, Zeyad Al-Shaibani, Arjun Law, Wilson Lam, Fotios V. Michelis, Auro Viswabandya, Jeffrey H. Lipton, Rajat Kumar, Jonas Mattsson, Zhaolei Zhang, Tamir Biezuner, Liran I. Shlush, Dennis Dong Hwan Kim
Journal: Blood (2019)
miRNA-Mediated Suppression of a Cardioprotective Cardiokine as a Novel Mechanism Exacerbating Post-MI Remodeling by Sleep Breathing Disorders
Authors: Yunhui Du, Xiao Wang, Linyi Li, Wenjing Hao, Huina Zhang, Yu Li, Yanwen Qin, Shaoping Nie, Theodore A. Christopher, Bernard L. Lopez, Wayne Bond Lau, Yajing Wang, Xin-Liang Ma, Yongxiang Wei
Journal: Circulation Research (2019)

Obstructive sleep apnea-hypopnea syndrome, a sleep breathing disorder in which chronic intermittent hypoxia (CIH) is the primary pathology, is associated with multiple cardiovascular diseases. However, whether and how CIH may affect cardiac remodeling following myocardial infarction (MI) remains unknown.To determine whether CIH exposure at different periods of MI may exacerbate post-MI heart failure and to identify the mechanisms underlying CIH-exacerbated post-MI remodeling.Adult male mice were subjected to MI (4 weeks) with and without CIH (4 or 8 weeks). CIH before MI (CIH+MI) had no significant effect on post-MI remodeling. However, double CIH exposure (CIH+MI+CIH) or CIH only during the MI period (MI+CIH) significantly exacerbated pathological remodeling and reduced survival rate. Mechanistically, CIH activated TGF-β (tumor growth factor-β)/Smad (homologs of both the Drosophila protein MAD and the C. elegans protein SMA) signaling and enhanced cardiac epithelial to mesenchymal transition, markedly increasing post-MI cardiac fibrosis. Transcriptome analysis revealed that, among 15 genes significantly downregulated (MI+CIH versus MI), Ctrp9 (a novel cardioprotective cardiokine) was one of the most significantly inhibited genes. Real-time polymerase chain reaction/Western analysis confirmed that cardiomyocyte CTRP9 expression was significantly reduced in MI+CIH mice. RNA-sequencing, real-time polymerase chain reaction, and dual-luciferase reporter assays identified that microRNA-214-3p is a novel Ctrp9 targeting miRNA. Its upregulation is responsible for Ctrp9 gene suppression in MI+CIH. Finally, AAV9 (adeno-associated virus 9)-mediated cardiac-specific CTRP9 overexpression or rCTRP9 (recombinated CTRP9) administration inhibited TGF-β/Smad and Wnt/β-catenin pathways, attenuated interstitial fibrosis, improved cardiac function, and enhanced survival rate in MI+CIH animals.This study provides the first evidence that MI+CIH upregulates miR-214-3p, suppresses cardiac CTRP9 (C1q tumor necrosis factor-related protein-9) expression, and exacerbates cardiac remodeling, suggesting that CTRP9 may be a novel therapeutic target against pathological remodeling in MI patients with obstructive sleep apnea-hypopnea syndrome.
GPs are advised to ignore genetic test results that have no clinical basis
Authors: Elisabeth Mahase
Journal: BMJ (2019)

GPs should “not take at face value, or attempt to interpret” reports from direct to consumer (DTC) genetic tests, according to the Royal College of General Practitioners (RCGP).1

In an official position statement, the college warned that there is a “very high chance of false positive or false negative results” from DTC genetic tests and “significant NHS costs in confirming (or more often refuting)” the results.

DTC genetic tests have become popular in the UK in recent years as the technology …
Effect of Surgical Versus Medical Therapy on Diabetic Kidney Disease Over 5 Years in Severely Obese Adolescents With Type 2 Diabetes
Authors: Petter Bjornstad, Kara Hughan, Megan M. Kelsey, Amy S. Shah, Jane Lynch, Edward Nehus, Mark Mitsnefes, Todd Jenkins, Peixin Xu, Changchun Xie, Thomas Inge, Kristen Nadeau
Journal: Diabetes Care (2019)

To compare diabetic kidney disease (DKD) rates over 5 years of follow-up in two cohorts of severely obese adolescents with type 2 diabetes (T2D) undergoing medical or surgical treatment for T2D.A secondary analysis was performed of data collected from obese participants of similar age and racial distribution enrolled in the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) and the Treatment Options of Type 2 Diabetes in Adolescents and Youth (TODAY) studies. Teen-LABS participants underwent metabolic bariatric surgery (MBS). TODAY participants were randomized to metformin alone or in combination with rosiglitazone or intensive lifestyle intervention, with insulin therapy given for glycemic progression. Glycemic control, BMI, estimated glomerular filtration rate (eGFR), urinary albumin excretion (UAE), and prevalence of hyperfiltration (eGFR ≥135 mL/min/1.73 m2) and elevated UAE (≥30 mg/g) were assessed annually.Participants with T2D from Teen-LABS (n = 30, mean ± SD age, 16.9 ± 1.3 years; 70% female; 60% white; BMI 54.4 ± 9.5 kg/m2) and TODAY (n = 63, age 15.3 ± 1.3 years; 56% female; 71% white; BMI 40.5 ± 4.9 kg/m2) were compared. During 5 years of follow-up, hyperfiltration decreased from 21% to 18% in Teen-LABS and increased from 7% to 48% in TODAY. Elevated UAE decreased from 27% to 5% in Teen-LABS and increased from 21% to 43% in TODAY. Adjusting for baseline age, sex, BMI, and HbA1c, TODAY participants had a greater odds of hyperfiltration (odds ratio 15.7 [95% CI 2.6, 94.3]) and elevated UAE (27.3 [4.9, 149.9]) at 5 years of follow-up.Compared with MBS, medical treatment of obese youth with T2D was associated with a higher odds of DKD over 5 years.
Crowdsourced High-Risk Classifiers for Multiple Myeloma Patients Commonly Identify PHF19 As a Robust Progression Biomarker
Authors: Michael J Mason, Carolina D. Schinke, Christine Eng, Fadi Towfic, Fred Gruber, Brian S. White, Yi Cui, Bailiang Li, Thomas Yu, William S. Dalton, Hartmut Goldschmidt, Herve Avet-Loiseau, Mehmet Samur, Maria Ortiz, Matthew Trotter, Boris Hayete, Andrew Dervan, Erin Flynt, Hongyue Dai, Douglas Bassett, Pieter Sonneveld, Kenneth H. Shain, Nikhil C. Munshi, Daniel Auclair, Dirk Hose, Gareth Morgan, Jonathan Göke, Brian A Walker, Anjan Thakurta, Justin Guinney
Journal: Blood (2019)
Increased Risk of Early Hematologic Toxicity during Maintenance Therapy in Acute Lymphoblastic Leukemia Patients of South Indian Origin Carrying NUDT15*3 Allele
Authors: Sunitha Kodidela, Dorababu Patchva, Dimpal Thakkar:, Biswajit Dubashi, Rajan Sundaram, Ravi Prasad Nidanapu, Muralidharan Nivedita, Anil Aribandi, Suresh Chandra Pradhan, Chakradhara RS Uppugunduri
Journal: Blood (2019)
Abstract 12758: Cardiac Arrest After Cardiac Surgery is Associated With High In-Hospital and Long-Term Mortality
Authors: Jessica Voight, Kairav Vakil, M Chadi Alraies, Santiago Garcia, Edward McFalls, Selcuk Adabag
Journal: Circulation (2015)

Introduction: Cardiac arrest is a grave complication after cardiac surgery with a case fatality rate of ~60%. However, the long-term mortality and outcomes of post-operative patients who survived cardiac arrest is less clear. Methods: We examined the mortality and outcomes of 6,979 consecutive patients who underwent cardiac surgery from at the Minneapolis VA Medical Center from 1991 to 2014. Data was collected prospectively. Results: The mean age was 66 ± 9 years, 99% of the patients were male and 72% had coronary artery bypass graft surgery. In total, 182 (2.6%) patients had a cardiac arrest (median 3 days; range 0-39 days) after surgery. Of these, 93 (51%) died during the same hospitalization and an additional 24 (13%) died within 1 year. Mortality at 30-days (51% vs. 1.9%; p &lt;0.0001), at 1-year (64% vs. 6%; p &lt;0.0001), and after 7.5±5.5 years of follow-up (81% vs. 34%; p&lt;0.0001), was higher in those with vs. without cardiac arrest (Figure 1). After adjusting for age, sex, year, and type of surgery, having an in-hospital cardiac arrest was associated with a 4.7 (95% CI 3.9-5.6; p &lt; 0.0001) times higher risk of long-term mortality in the whole cohort, 2.0 (95% CI 1.6-2.7; p &lt; 0.0001) times higher risk among those who survived 30 days after surgery, and 1.3 (95% CI 0.9-1.9; p = 0.14) times higher risk among those who survived 1 year. Independent predictors of death among cardiac arrest patients who were discharged alive include being discharged to a facility (HR 3.97; 95% CI 1.52-10.32; p=0.005) and renal dysfunction (HR 3.35; 95% CI 1.42-7.89; p=0.006). Conclusions: Long-term mortality remains very high in patients who were discharged alive after a postoperative cardiac arrest. Discharge disposition and renal dysfunction may have important prognostic implications in these patients.
Prevalence and clinical associations of Staphylococcus aureus small-colony variant respiratory infection in children with cystic fibrosis (SCVSA): a multicentre, observational study
Authors: Daniel J Wolter, Frankline M Onchiri, Julia Emerson, Mimi R Precit, Michael Lee, Sharon McNamara, Laura Nay, Marcella Blackledge, Ahmet Uluer, David M Orenstein, Michelle Mann, Wynton Hoover, Ronald L Gibson, Jane L Burns, Lucas R Hoffman, Daniel J Wolter, Frankline M Onchiri, Julia Emerson, Mimi R Precit, Michael Lee, Sharon McNamara, Laura Nay, Marcella Blackledge, Ahmet Uluer, David M Orenstein, Michelle Mann, Wynton Hoover, Ronald L Gibson, Jane L Burns, Xuan Qin, Anne Marie Buccat, Alan Genatossio, Nicoline Schaap, Omalee Lopez, Kathy Doan, Robert Fowler, Khadija Iken, Kelsey Little, Elizabeth Hartigan, Kathryn Little, Heather Hathorne, Susan Keeling, Katie Slaten, Lucas R Hoffman
Journal: The Lancet Respiratory Medicine (2019)
Mosunetuzumab Induces Complete Remissions in Poor Prognosis Non-Hodgkin Lymphoma Patients, Including Those Who Are Resistant to or Relapsing After Chimeric Antigen Receptor T-Cell (CAR-T) Therapies, and Is Active in Treatment through Multiple Lines
Authors: Stephen J Schuster, Nancy L Bartlett, Sarit Assouline, Sung-Soo Yoon, Francesc Bosch, Laurie H Sehn, Chan Y. Cheah, Mazyar Shadman, Gareth P Gregory, Matthew Ku, Michael C Wei, Shen Yin, Antonia Kwan, Kasra Yousefi, Genevive Hernandez, Chi-Chung Li, Carol O'Hear, Lihua E Budde
Journal: Blood (2019)
Impact and Outcomes of RAS gene Mutations in Core Binding Factor Acute Myeloid Leukemia
Authors: Hassan Awada, Ashwin Kishtagari, Teodora Kuzmanovic, Jibran Durrani, Cassandra M Kerr, Manja Meggendorfer, Anjali S. Advani, Aziz Nazha, Hetty E. Carraway, Torsten Haferlach, Mikkael A. Sekeres, Valeria Visconte, Jaroslaw P. Maciejewski
Journal: Blood (2019)
Hodgkin Lymphoma Outcomes: Can We Expect Ethnic Parity in a Hispanic Prevalent Population?
Authors: Michelle Janania Martinez, Prathibha Surapaneni, Juan F Garza, Tyler W Snedden, Snegha Ananth, Jeremy Rawlings, David J Gregorio, Sushanth Kakarla, Qianqian Liu, Joel E Michalek, Adolfo Enrique Diaz
Journal: Blood (2019)
Distinct, Ethnic, Clinical, and Genetic Characteristics of Myelodysplastic Syndromes with Der(1;7)
Authors: Rurika Okuda, Hideki Makishima, Yasuhito Nannya, Yotaro Ochi, Tetsuichi Yoshizato, Yasunobu Nagata, Kenichi Yoshida, Masashi Sanada, June Takeda, Ryunosuke Saiki, Yuichi Shiraishi, Satoru Miyano, Wolfgang Kern, Constance Baer, Niroshan Nadarajah, Claudia Haferlach, Yoshiko Atsuta, Senji Kasahara, Hiroshi Handa, Shigeru Chiba, Torsten Haferlach, Seishi Ogawa
Journal: Blood (2019)
Higher matrix stiffness as an independent initiator triggers epithelial-mesenchymal transition and facilitates HCC metastasis
Authors: Yinying Dong, Qiongdan Zheng, Zhiming Wang, Xiahui Lin, Yang You, Sifan Wu, Yaohui Wang, Chao Hu, Xiaoying Xie, Jie Chen, Dongmei Gao, Yan Zhao, Weizhong Wu, Yinkun Liu, Zhenggang Ren, Rongxin Chen, Jiefeng Cui
Journal: Journal of Hematology & Oncology (2019)

Abstract Background Increased liver stiffness exerts a detrimental role in driving hepatocellular carcinoma (HCC) malignancy and progression, and indicates a high risk of unfavorable outcomes. However, it remains largely unknown how liver matrix stiffness as an independent cue triggers epithelial-mesenchymal transition (EMT) and facilitates HCC metastasis. Methods Buffalo rat HCC models with different liver stiffness backgrounds and an in vitro Col I-coated cell culture system with tunable stiffness were used in the study to explore the effects of matrix stiffness on EMT occurrence and its underlying molecular mechanism. Clinical significance of liver stiffness and key molecules required for stiffness-induced EMT were validated in HCC cohorts with different liver stiffness. Results HCC xenografts grown in higher stiffness liver exhibited worse malignant phenotypes and higher lung metastasis rate, suggesting that higher liver stiffness promotes HCC invasion and metastasis. Cell tests in vitro showed that higher matrix stiffness was able to strikingly strengthen malignant phenotypes and independently induce EMT occurrence in HCC cells, and three signaling pathways converging on Snail expression participated in stiffness-mediated effect on EMT including integrin-mediated S100A11 membrane translocation, eIF4E phosphorylation, and TGF β1 autocrine. Additionally, the key molecules required for stiffness-induced EMT were highly expressed in tumor tissues of HCC patients with higher liver stiffness and correlated with poor tumor differentiation and higher recurrence. Conclusions Higher matrix stiffness as an initiator triggers epithelial-mesenchymal transition (EMT) in HCC cells independently, and three signaling pathways converging on Snail expression contribute to this pathological process. This work highlights a significant role of biomechanical signal in triggering EMT and facilitating HCC invasion and metastasis.
Utility of Newborn Screening for Severe Combined Immunodeficiency and X-Linked Agammaglobulinemia Using TREC and KREC Assays
Authors: Manabu Wakamatsu, Hideki Muramatsu, Shinsuke Kataoka, Yusuke Okuno, Sakai Yoshimi, Yoko Nakajima, Tetsuya Ito, Ikuya Tsuge, Seiji Kojima, Yoshiyuki Takahashi
Journal: Blood (2019)
Predictors of Efficacy for Blinatumomab in BCP-ALL Patients: Non-Responders Show Impaired CD19-BiTE®-Mediated Cytotoxicity in Vitro
Authors: Veit Bücklein, Michaela Scheurer, Bettina Brauchle, Roman Kischel, Michael von Bergwelt, Karsten Spiekermann, Marion Subklewe
Journal: Blood (2019)
Comprehensive Analysis of 22 Cases with Blastic Plasmacytoid Dendritic Cell Neoplasm Reveals Mutations in DNA Repair Genes and Two Distinct Subgroups Defined By Differential Gene Expression with Prognostic Impact
Authors: Anna Stengel, Wencke Walter, Constance Baer, Manja Meggendorfer, Wolfgang Kern, Torsten Haferlach, Claudia Haferlach
Journal: Blood (2019)
Impact of Antibiotics on Gut Microbiota Diversity and the Results of a Prospective Dietary Assessment in Patients with Multiple Myeloma Undergoing Autologous Hematopoietic Stem Cell Transplantation
Authors: Christopher D'Angelo, Sailendharan Sudakaran, Peiman Hematti, Fotis Asimakopoulos, Craig Augustine, Nasia Safdar, Natalie Scott Callander
Journal: Blood (2019)
A Retrospective Real-World Study of the Current Treatment Pathways for Myelofibrosis in the UK (The REALISM UK Study)
Authors: Adam J. Mead, Tim Somervaille, Nauman M Butt, Waseem Nagi, Alastair J Whiteway, Suriya Kirkpatrick, Ciro R Rinaldi, Catherine Roughley, Sam Ackroyd, Joanne Ewing, Pratap Neelakantan, Mamta Garg, Claire N Harrison, David Tucker, Rozinder Bains, Gavin Chiu, Joe Hickey
Journal: Blood (2019)
CMET-09. A UNIQUE CASE OF PRIMARY GLIOSARCOMA WITH METASTASIS TO SACRUM ON BEVACIZUMAB
Authors: Maya Hrachova, Kong Xiao-Tang, Mari Perez Rosenthal
Journal: Neuro-Oncology (2019)

Abstract INTRODUCTION Gliosarcoma is a rare variant of glioblastoma that accounts for approximately 0.48% of all adult brain tumors. Although, metastatic potential of gliosarcoma via hematogenous route has been proposed in the past, we report the first case of metastasis to the sacrum while undergoing treatment on bevacizumab. CASE REPORT: A 40-year-old woman presented with acute onset severe headache with pertinent examination findings of left upper extremity pronator drift. Imaging revealed right frontal lobe enhancing mass measuring 4.5 x 3.7 cm associated with edema and 10 mm leftward midline shift. A right frontal craniotomy for tumor debulking showed gliosarcoma (IDH wild-type, WHO grade 4). She was initiated on radiotherapy with concomitant and adjuvant temozolomide via Stupp’s protocol after second debulking surgery. Chemotherapy regimen was changed to bevacizumab when tumor progression was identified. Within six months of initiation of bevacizumab, she developed left leg shooting pain. Imaging revealed heterogeneously enhancing mass in the left hemisacral region measuring 6.2 cm concerning for metastatic process. Sacral bone biopsy showed malignant cells which were negative for an extensive immunohistochemical panel (including GFAP and Olig2), suggesting metastasis of the sarcomatous element of gliosarcoma and arguing against a second malignancy. Next generation sequencing performed on both the intracranial and sacral tumor showed an identical molecular prolife (including PTEN, NF1, TERT and TP53 genomic alterations), confirming common origin. After completion of radiation therapy to sacral region, chemotherapy regimen included lomustine followed by pembrolizumab. The patient died at 14 months after initial presentation due to disease progression. DISCUSSION To the best of our knowledge, this is the first case primary of gliosarcoma with metastases to the sacrum while evolved on chemotherapy with bevacizumab. The aim of this report is to bring awareness to medical community in order to expedite the diagnosis and management.
Updated Results of a Phase II Study of Reduced-Intensity Chemotherapy with Mini-Hyper-CVD in Combination with Inotuzumab Ozogamicin, with or without Blinatumomab, in Older Adults with Newly Diagnosed Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia
Authors: Nicholas J. Short, Hagop M. Kantarjian, Farhad Ravandi, Xuelin Huang, Nitin Jain, Koji Sasaki, Rita Khouri, Naval G. Daver, Naveen Pemmaraju, Joseph D. Khoury, Jeffrey L. Jorgensen, Yesid Alvarado, Marina Y Konopleva, Guillermo Garcia-Manero, Tapan M. Kadia, Musa E. Yilmaz, Gautam M. Borthakur, Jan A. Burger, Steven M. Kornblau, William G. Wierda, Courtney D. DiNardo, Alessandra Ferrajoli, Jovitta Jacob, Meagan Rostykus, Rebecca Garris, Marygrace Ward, Binru Huang, Corabelle Encarnacion, Christopher Loiselle, Susan M. O'Brien, Elias Jabbour
Journal: Blood (2019)
Impact of Anti-CD19 CAR-T Axicabtagene Ciloleucel on Vaccine Titers of DTaP and MMR
Authors: Zaid Abdel Rahman, Nicole Gannon, Megan Melody, Paul Muniz, Ernesto Ayala, Vivek Roy, Lisa Brumble, Sikander Ailawadhi, Taimur Sher, James M. Foran, Hemant S. Murthy, Han W. Tun, Candido E. Rivera, Asher A. Chanan-Khan, Abba C. Zubair, Mohamed A Kharfan-Dabaja
Journal: Blood (2019)
High Incidence of Herpes Zoster after Cord Blood Hematopoietic Cell Transplant Despite Longer Duration of Antiviral Prophylaxis
Authors: Elisabetta Xue, Hu Xie, Wendy Leisenring, Louise E Kimball, Sonia Goyal, Lisa Chung, Rachel Blazevic, Byron Maltez, Ann Dahlberg, Rachel B. Salit, Colleen Delaney, Steven A. Pergam, Michael Boeckh, Filippo Milano, Joshua Aiden Hill
Journal: Blood (2019)
Age Matters: Younger Unrelated PBSC Donors Experience Less G-CSF-Related Symptoms and Have a Faster Emotional Recovery Than Older Donors
Authors: Jose ROS Soto, Eva Zoubek, Richard Szydlo, Paul Johnson, Ann O'Leary, Maria Del Mar Cuadrado, Catherine Burlton, J. Alejandro Madrigal, Chloe Anthias
Journal: Blood (2019)
Vaccination Against Measles
Authors: P VUORINEN
Journal: BMJ (1963)

discusses the effects of mitral stenosis on pulmonary function.The sequence of changes is "clearly bound up with the physical changes . . . in the lung parenchyma as a result of pulmonary hypertension" (p.765).Radio Pills: Workers at M.R.C. Gastroenterology Research Unit describe the use of " radio pills " for recording pressure, tempera- ture, and pH in the gut (p.771).B.P. and Nutrition: Report from Indonesian Nutrition Institute suggests that very low pro- tein intake does not lower the systolic blood pressure (p.775).Guanethidine: Edinburgh workers conclude that guanethidine combined with an oral diuretic is "better than previously available drugs" for the long-term treatment of severe hypertension, but it has disadvantages (p.t76).Methyldopa and Reserpine: A New Zealand report compares these drugs, each combined with hydrochlorothiazide, in management of hypertension.Neither was ideal (p.781).Nitrogen Mustard Therapy: Workers in Nairobi report on haemodynamic effects of aortic occlusion during chemotherapy of ana- plastic post-nasal cancers (p.783).
MANIFEST, a Phase 2 Study of CPI-0610, a Bromodomain and Extraterminal Domain Inhibitor (BETi), As Monotherapy or "Add-on" to Ruxolitinib, in Patients with Refractory or Intolerant Advanced Myelofibrosis
Authors: John Mascarenhas, Marina Kremyanskaya, Ronald Hoffman, Prithviraj Bose, Moshe Talpaz, Claire N Harrison, Vikas Gupta, Brian Leber, Shireen Sirhan, Sujan Kabir, Adrian Senderowicz, James Shao, Jennifer Mertz, Patrick Trojer, Srdan Verstovsek
Journal: Blood (2019)