FRI0720-HPR DEVELOPMENT AND VALIDATION OF A SELF-ADMINISTRATED QUESTIONNAIRE MEASURING ESSENTIAL KNOWLEDGE FOR PATIENTS WITH RHEUMATOID ARTHRITIS: THE RHEUMATOID ARTHRITIS ASSESSMENT KNOWLEDGE QUESTIONNAIRE (RAKE)
Authors: Malory Rodere, Bruno Pereira, Martin Soubrier, Sonia Tropé, Francoise Fayet, Jean David Cohen, Muriel Piperno, Beatrice Pallot Prades, Sophie Pouplin, Pascal Coquerelle, Laurent Grange, Christelle Sordet, Laure Gossec, Catherine Beauvais
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> Improving knowledge and skills is recommended for patients with rheumatoid arthritis (RA) to enhance self-management. Measuring knowledge is also part of the educative approach. However, the available Knowledge questionnaires (KQs) (ref 1,2) needed to be updated according to recent recommendations for RA management and the patients' needs (ref 3). <h3>Objectives</h3> To develop and a validate a new KQ in RA. <h3>Methods</h3> 4 steps. Step1. Selection of knowledge considered essential for patients with RA through Delphi rounds by a working group of rheumatologists, health professionals (HPs) and patients leading to a list of consensual items (ref3). Step2. Two rheumatologists and a rheumatology nurse constructed the first version of the KQ, each question of the KQ referring to a selected item on the list. The formulation was then amended by the working group. A new version was elaborated during a face-to-face meeting of 3 HPs and one patient. Step 3. The KQ was submitted to ten patients for cognitive debriefing, comments were analysed and a the final version was elabored. Step 4. Multicentric validation in 11 rheumatology departments: acceptability was measured by the rates of missing data per item, reproducibility and sensitivity to change were assessed respectively by test/retest at a 2 weeks interval (Lin's concordance correlation coefficient) and by testing the KQ before and after patient education sessions. The sample size estimation and statistical analyses were conducted according to COSMIN recommendations, especially concerning thresholds of metrological indexes. <h3>Results</h3> Step1 obtained 45 knowledge items, 32 considered essential and 13 considered useful, selected respectively by more than 2/3 and more than 50% of participants to the Delphi rounds, leading to the RAKE: a 45-items questionnaire, with a 32-items short form. The RAKE contains 6 knowledge domains: disease knowledge (10 items), pharmacological treatment (14), non -pharmacological treatment (7), comorbidities (1), self-care for pain and fatigue (5), adaptative skills to psychosocial and professional issues and health care system (8). The validation included 130 patients, 108 (83%) women, mean age 56.4±12.10 years, median disease duration 9 years [4; 23]. The missing data rate per item was &lt;0,05. The RAKE's internal validity (Kuder-Richardson) was 0.90. Reproducibility (in 72 patients) was 0.86 [0.80; 0.92]. Sensitivity to change was measured in 54 patients. A statistically significant difference in total knowledge score was observed between the two assessment times: 30.1±7.4 vs. 37.7±5.7 (p&lt;0.001), representing an effect size &gt;1.1 [0.7; 1.6]. The RAKE's external validity was confirmed by correlation with the RAID score of 0.16 (p=0.08). <h3>Conclusion</h3> This study enabled the development and the validation of the RAKE, a Knowledge questionnaire for patients with RA, with a good acceptability, reproducibility and sensitivity to change. This KQ will be helpful to assess the process of knowledge acquisition in patient education approaches. <h3>References</h3> [1] Hill and al., Br J Rheumatol. 1991,30 :45-9. Lineker and al., J Rheumatol. 1997, 24(4):647-53. Beauvais C, et al. ARD 2015; 74, suppl 2. <h3>Disclosure of Interests</h3> Malory RODERE: None declared, Bruno Pereira: None declared, Martin SOUBRIER: None declared, Sonia Tropé: None declared, Francoise Fayet: None declared, Jean David COHEN: None declared, Muriel PIPERNO: None declared, Beatrice Pallot Prades: None declared, Sophie Pouplin: None declared, Pascal COQUERELLE: None declared, LAURENT GRANGE Consultant for: Laurent Grange has received honoraria from Amgen, Lilly and UCB and research support from Lilly, Amgen, UCB, Expanscience, Mylan, Roche diagnostics and TEVA, Christelle Sordet: None declared, Laure Gossec Grant/research support from: AbbVie, BMS, Celgene, Janssen, Lilly, MSD, Novartis-Sandoz, Pfizer, Sanofi, and UCB, Consultant for: AbbVie, Biogen, BMS, Celgene, Janssen, Lilly, MSD, Nordic Pharma, Novartis-Sandoz, Pfizer, Roche, Sanofi, and UCB, Consultant for: L Gossec has received honoraria from Celgene as investigator for this study, Catherine Beauvais: None declared