Ciprofloxacin versus Tobramycin for Neutropenic Fevers
Authors: Gerald P. Bodey, Kenneth V.I. Rolston, Issam I. Raad
Journal: Annals of Internal Medicine (2003)

Letters4 March 2003Ciprofloxacin versus Tobramycin for Neutropenic FeversGerald P. Bodey, MD, Kenneth V.I. Rolston, MD, and Issam I. Raad, MDGerald P. Bodey, MDUniversity of Texas M.D. Anderson Cancer Center; Houston, TX 77030 (Bodey, Rolston, Raad)Search for more papers by this author, Kenneth V.I. Rolston, MDUniversity of Texas M.D. Anderson Cancer Center; Houston, TX 77030 (Bodey, Rolston, Raad)Search for more papers by this author, and Issam I. Raad, MDUniversity of Texas M.D. Anderson Cancer Center; Houston, TX 77030 (Bodey, Rolston, Raad)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-5-200303040-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Peacock and colleagues (1) raise the following question: What response rate is acceptable for an antibiotic regimen used to treat presumed or proven infection in neutropenic patients? The authors reported an overall success rate of only 27% for ciprofloxacinpiperacillin and 22% for tobramycinpiperacillin. Response rates for clinically and microbiologically documented infections with each agent were 22% and 16%. The authors concluded that ciprofloxacinpiperacillin is another clinically proven regimen for neutropenic patients.The first randomized trial of empirical antibiotic therapy for presumed or proven infection in neutropenic patients was conducted at our institution (2). The response rates for ...References1. Peacock JE, Herrington DA, Wade JC, Lazarus HM, Reed MD, Sinclair JW, . Ciprofloxacin plus piperacillin compared with tobramycin plus piperacillin as empirical therapy in febrile neutropenic patients. A randomized, double-blind trial. Ann Intern Med. 2002;137:77-87. [PMID: 12118962] LinkGoogle Scholar2. Middleman EA, Watanabe A, Kaizer H, Bodey GP. Antibiotic combinations for infections in neutropenic patients. Evaluation of carbenicillin plus either cephalothin or kanamycin. Cancer. 1972;30:573-9. CrossrefMedlineGoogle Scholar3. Winston DJ, Bartoni K, Bruckner DA, Schiller GJ, Territo MC. Randomized comparison of sulbactam/cefoperazone with imipenem as empirical monotherapy for febrile granulocytopenic patients. Clin Infect Dis. 1998;26:576-83. [PMID: 9524826] CrossrefMedlineGoogle Scholar4. Valdivieso M, Horikoshi N, Rodriguez V, Bodey GP. Therapeutic trials with tobramycin. Am J Med Sci. 1974;268:149-56. [PMID: 4613176] CrossrefMedlineGoogle Scholar5. Klastersky J, Glauser MP, Schimpff SC, Zinner SH, Gaya H. Prospective randomized comparison of three antibiotic regimens for empirical therapy of suspected bacteremic infection in febrile granulocytopenic patients. Antimicrob Agents Chemother. 1986;29:263-70. [PMID: 3521475] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Texas M.D. Anderson Cancer Center; Houston, TX 77030 (Bodey, Rolston, Raad) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCiprofloxacin plus Piperacillin Compared with Tobramycin plus Piperacillin as Empirical Therapy in Febrile Neutropenic Patients James E. Peacock Jr. , Deirdre A. Herrington , James C. Wade , Hillard M. Lazarus , Michael D. Reed , Jane W. Sinclair , Daniel C. Haverstock , Steven F. Kowalsky , David D. Hurd , Deborah A. Cushing , Colleen P. Harman , and Gerald R. Donowitz Ciprofloxacin versus Tobramycin for Neutropenic Fevers Darren R. Linkin and Neil Fishman Ciprofloxacin versus Tobramycin for Neutropenic Fevers Gerald R. Donowitz and James E. Peacock Jr. Metrics Cited ByA prospective, controlled, randomized, non-blind, comparative study of the efficacy and safety of a once daily high dose of ceftriaxone plus ciprofloxacin versus thrice daily ceftazidime plus amikacin in empirical therapy for febrile neutropenic patients 4 March 2003Volume 138, Issue 5Page: 435KeywordsAntibioticsBacteriaBone marrowDrugsFever of unknown originFeversHyperthermiaNeutrophilsRandomized trialsSuperinfections ePublished: 4 March 2003 Issue Published: 4 March 2003 CopyrightCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...