tbuckley/cabot-search huggingface dataset:
Abstract P217: Impact of Serum Potassium on Mortality and Kidney Outcomes in the Atherosclerosis Risk in Communities (ARIC) Study
Authors: Yan Chen, Alex R Chang, Josef Coresh, Mara A McAdams-Demarco, Lesley A Inker, Morgan E Grams
Journal: Circulation (2016)

Introduction: Little is known about whether abnormal values of serum potassium (K) are associated with mortality and adverse renal outcomes in the general population. Hypothesis: Abnormal K values are associated with higher risk of mortality and adverse renal outcomes, with stronger associations among persons taking medications that influence K levels. Methods: We studied 15,641 participants in the ARIC study. Cox proportional hazard regression was used to investigate the association of K at baseline (1987-1989), evaluated categorically (hypokalemia, &lt;3.5 mmol/L; normokalemia, 3.5-5.4 mmol/L; hyperkalemia, ≥5.5 mmol/L) and continuously using linear spline terms (knots at 3.5 and 5.5 mmol/L), with mortality, incident chronic kidney disease (CKD), and end-stage renal disease (ESRD). We also evaluated whether kaliuretic diuretics modified the association between K and adverse outcomes. Results: Overall, 2.7% of the participants had hypokalemia, 2.1% had hyperkalemia and 19.1% were taking kaliuretic diuretics. In an unadjusted model, both hypo- and hyperkalemia were associated with mortality; in a fully adjusted model, hyperkalemia was significantly associated with mortality (HR: 1.24; 95% CI: 1.04-1.49) while hypokalemia was not (HR: 1.03; 95% CI: 0.89-1.20); however, hypokalemia was associated with mortality among people not taking kaliuretic diuretics (HR: 1.74; 95% CI: 1.31-2.30; p for interaction: &lt;0.001). Neither hypo- nor hyperkalemia was associated with renal outcomes in the adjusted model; however, there was an interaction of kaliuretic diuretic use with hypokalemia, where hypokalemia was associated with significantly higher risk of CKD and ESRD in participants not using kaliuretic diuretics and lower risk in participants using kaliuretic diuretics (CKD: p for interaction: 0.001; ESRD: p for interaction: 0.002). Conclusions: Abnormal values of K were associated with death and adverse renal outcomes in the general population, particularly among participants not taking kaliuretic diuretics.
SAT-280-Comparison of CAP, MRI-PDFF, Steatotest, FLI and HSI performances for diagnosing NAFLD and NASH in morbidly obese patients undergoing bariatric surgery
Authors: philippe garteiser, Laurent Castera, Muriel Coupaye, Sabrina Doblas, Daniella Calabrese, Séverine Ledoux, Pierre Bedossa, Marina Esposito-Farese, Fadia Dib, Simon Msika, Bernard van Beers, Pauline Jouet
Journal: Journal of Hepatology (2019)
THU-503-Macrophage migration inhibitory factor shows a pro-proliferative and anti-apoptotic effect on hepatoma cells in vitro and promotes tumour growth in vivo
Authors: Theresa Hildegard Wirtz, Daniel Heinrichs, Saal Alena, Bergmann lrina, Petra Fischer, Janine Koehncke, Elisa Brandt, Jürgen Bernhagen, Christian Trautwein, Marie-Luise Berre
Journal: Journal of Hepatology (2019)
THU-063-Synergistic antifibrotic effect of rapamycin and zoledronic acid in advanced murine biliary fibrosis
Authors: Misbah Aslam, Muhammad Ashfaq-Khan, Asif Qureshi, Marcel Senkowski, Mirko nick, Yong Ook Kim, Leonard Kaps, Detlef Schuppan
Journal: Journal of Hepatology (2019)
Prevalence of Spontaneous Clearance of Hepatitis C Virus Infection Doubled From 1998 to 2017
Authors: Suk Seo, Michael J. Silverberg, Leo B. Hurley, Joanna Ready, Varun Saxena, David Witt, C. Bradley Hare, Jamila H. Champsi, Daniel G. Korn, Mary Patricia Pauly, Scott Chamberland, Jennifer B. Lai, Julia L. Marcus
Journal: Clinical Gastroenterology and Hepatology (2019)
Safety and efficacy of VRC01 broadly neutralising antibodies in adults with acutely treated HIV (RV397): a phase 2, randomised, double-blind, placebo-controlled trial
Authors: Trevor A Crowell, Donn J Colby, Suteeraporn Pinyakorn, Carlo Sacdalan, Amélie Pagliuzza, Jintana Intasan, Khunthalee Benjapornpong, Kamonkan Tangnaree, Nitiya Chomchey, Eugène Kroon, Mark S de Souza, Sodsai Tovanabutra, Morgane Rolland, Michael A Eller, Dominic Paquin-Proulx, Diane L Bolton, Andrey Tokarev, Rasmi Thomas, Hiroshi Takata, Lydie Trautmann, Shelly J Krebs, Kayvon Modjarrad, Adrian B McDermott, Robert T Bailer, Nicole Doria-Rose, Bijal Patel, Robert J Gorelick, Brandie A Fullmer, Alexandra Schuetz, Pornsuk V Grandin, Robert J O'Connell, Julie E Ledgerwood, Barney S Graham, Randall Tressler, John R Mascola, Nicolas Chomont, Nelson L Michael, Merlin L Robb, Nittaya Phanuphak, Jintanat Ananworanich, Julie A. Ake, Siriwat Akapirat, Meera Bose, Evan Cale, Phillip Chan, Sararut Chanthaburanun, Nampueng Churikanont, Peter Dawson, Netsiri Dumrongpisutikul, Saowanit Getchalarat, Surat Jongrakthaitae, Krisada Jongsakul, Sukalaya Lerdlum, Sopark Manasnayakorn, Corinne McCullough, Mark Milazzo, Bessara Nuntapinit, Kier On, Madelaine Ouellette, Praphan Phanuphak, Eric Sanders-Buell, Nongluck Sangnoi, Shida Shangguan, Sunee Sirivichayakul, Nipattra Tragonlugsana, Rapee Trichavaroj, Sasiwimol Ubolyam, Sandhya Vasan, Phandee Wattanaboonyongcharoen, Thipvadee Yamchuenpong
Journal: The Lancet HIV (2019)
Use of Porphysomes to detect primary tumour, lymph node metastases, intra-abdominal metastases and as a tool for image-guided lymphadenectomy: proof of concept in endometrial cancer
Authors: Lauren Philp, Harley Chan, Marjan Rouzbahman, Marta Overchuk, Juan Chen, Gang Zheng, Marcus Q. Bernardini
Journal: Theranostics (2019)

Objective: To investigate Porphysome fluorescence image-guided resection (PYRO-FGR) for detection of uterine tumour, metastatic lymph nodes and abdominal metastases in a model of endometrial cancer.Methods: White New Zealand rabbits were inoculated with VX2 cells via intra-myometrial injection.At 30 days, Porphysomes were administered intravenously.At 24 h the abdomen was imaged and fluorescent tissue identified (PYRO-FGR).After complete resection of fluorescent tissue, fluorescence-negative lymph nodes and peritoneal biopsies were removed.Histopathology including ultra-staging and analysis by a pathologist was used to detect tumour.Fluorescence signal to background ratio (SBR) was calculated and VX2 (+) tissue compared to VX2 (-) tissue.Biodistribution was calculated and Porphysome accumulation in fluorescent VX2 (+) tissue compared to fluorescent VX2 (-) and non-fluorescent VX2 (-) tissue.Results: Of 17 VX2 models, 10 received 4 mg/kg of Porphysomes and 7 received 1 mg/kg.Seventeen tumours (UT), 81 lymph nodes (LN) and 54 abdominal metastases (AM) were fluorescence-positive and resected.Of these, 17 UT, 60 LN and 45 AM were VX2 (+), while 16 LN and 5 AM were VX2 (-).Nine specimens were excluded from analysis.Thirty-one LN and 53 peritoneal biopsies were fluorescence-negative and resected.Of these, all LN and 51/53 biopsies were VX2 (-) with only 2 false-negative biopsies.Sensitivity and specificity of PYRO-FGR for VX2 (+) tissue was 98.4% / 80.0% overall, 100% / 100% for UT, 100% / 66.0 % for LN and 95.7% / 91.4% for AM.Increased SBR and biodistribution was observed in VX2 (+) tissue vs. VX2 (-) tissue.Conclusions: Porphysomes are a highly sensitive imaging agent for intra-operative detection and resection of uterine tumour, metastatic lymph nodes and abdominal metastases.
Abstract 16125: Prognostic Value of C-Reactive Protein as Inflammatory Marker for Venous Thromboembolism in Acutely Ill Hospitalized Patients: Analysis From the APEX Trial
Authors: Gerald Chi, Michael Gibson, Adrian F Hernandez, Russell D Hull, Alexander T Cohen, Robert A Harrington, Yuyin Liu, Arzu Kalayci, Sargun Walia, Sadaf Sharfaei, Anmol Pitliya, Hassan A Kazmi, Sudarshana Datta, Farima Kahe, Eiman Ghaffarpasand, Mehrian Jafarizde, Megan K Yee, Ryan S Travis, Fahad AlKhalfan, Tarek Nafee, Mathieu Kerneis, Samuel Z Goldhaber
Journal: Circulation (2018)

Background: The link between inflammation and a long-term risk for venous thromboembolism (VTE) is supported by population-based studies. It remains uncertain whether C-reactive protein (CRP), an i...
Phase II, multicentre, open label, non randomized trial on safety of first line chemotherapy with oral metronomic vinorelbine in the elderly subgroup of NSCLC patients.
Authors: Domenico Amoroso, Lisette DelCorso, Marina Bergaglio, Andrea Bruzzone, Cheti Puccetti, Andrea Camerini, Rosa Filiberti, Alessandro Del Conte, Annalisa Brianti, Manlio Mencoboni
Journal: Journal of Clinical Oncology (2015)

e19015 Background: More than 50% of patients (pts)affected by NSCLC are close to 70 years old. Platinum-based chemotherapy is the cornerstone of treatment of advanced NSCLC, but in elderly pts, the balance between efficacy and toxicity of adding cisplatin to single-agent chemotherapy remains uncertain.Vinorelbine is one of the most studied drugs.An oral formulation of vinorelbine has been developed. Several studies have demonstrated that the pharmacokinetic parameters of the oral form were similar to those of the injectable formulation, but the compliance of patients may be higher.Oral administration at fixed doses of Vinorelbine might be a new way of administration of these drugs. So we designed a phase II, multicentre, open label, non- randomized trial on safety and efficacy of first line chemotherapy with oral metronomic vinorelbine in the elderly (age > 70) subgroup of advanced (stage IIIb – IV) NSCLC pts with PS 0-2. Methods: 76 patients were enrolled and oral vinorelbine at the dose of 50 mg three times a week was administered until progression or toxicity. Safety is the primary end point: if G3/4 toxicity after 3 months will affect more than 20% of patients the treatment will not be feasible. Toxicity were be recorded according to CTC-NCI 3.0. Secondary end points were OS, PFS, RR according to RECIST criteria. Results: median age was 79 (70-92). 80% were male. 84% of pts had 1-4 co-morbidities. 41% of pts had adenocarcinoma, 46% squamous carcinoma. 90% of pts were actual or former smokers. PS was 2 or more in 41% of pts, 1 in 33%. 15% of pts responded to therapy, 36% has stable disease and 45% had disease progression.70% pts showed G1-2 toxicity. G3-4 toxicity was present in 11% of pts.Median OS e PFS were 8 (95%CI 6.6-9.4) and 3 (95%CI 2.6-3.5) months respectively. Conclusions: Our data indicate that metronomic treatment seems feasible in this population of old and frail patients. Toxicity is manageable. OS and PFS are very interesting and claim for new larger studies.
Primary palliative care needs urgent attention
Authors: Sarah Mitchell, Amy Tan, Sebastien Moine, Jeremy Dale, Scott A Murray
Journal: BMJ (2019)

ABSTRACT  In males it is frequently testosterone (T) that activates the expression of sexually selected morphological and behavioral displays, but the role of T in regulating similar traits in females is less clear. Here, we combine correlational data with results from T and gonadotropin-releasing hormone (GnRH) manipulations in both sexes to assess the role of T in mediating sexually dimorphic coloration and morphology in the red-backed fairy-wren (Malurus melanocephalus). We show that: (1) natural variation in female expression of ornamental traits (darkened bills and red back feathers) is positively associated with age and circulating androgen titres, (2) females have the capacity to express most male-typical traits in response to exogenous T, including carotenoid-pigmented body plumage, shorter feathers, darkened bill and enlarged cloacal protuberance, but (3) appear constrained in production of male-typical melanin-pigmented plumage, and (4) low androgen levels during the pre-nuptial molt, probably because of low ovarian capacity for steroid production (or luteinizing hormone sensitivity), prevent females from developing male-like ornamentation. Thus, females appear to retain molecular mechanisms for hormonally regulated male-typical ornamentation, although these are rarely activated because of insufficient production of the hormonal signal.
THU-416-Use of telemedicine as a cost-effective program to achieve microelimination of hepatitis C virus infection among patients in a public healt care system in a low-income country
Authors: Jose Luis Perez Hernandez, Marco Antonio Navarrete Prida, Fernando Rogelio Espinosa Lopez, Lourdes De la Cruz, Carlos Araiza Casillas, Alberto Castillo Fierro, Fatima Higuera De La Tijera
Journal: Journal of Hepatology (2019)
Abstract P095: New Pediatric Hypertension Guidelines Alter Prevalence Distribution and Associations With Cardiovascular Risk Factors and Target Organ Damage in Youth
Authors: Michael Khoury, Phlip Khoury, Lawrence Dolan, Thomas Kimball, Elaine Urbina
Journal: Circulation (2018)

Introduction: A Clinical Practice Guideline (CPG) for pediatric hypertension was recently published, serving as an update to the previous guidelines (“4 th Report”). The CPG includes changes to the cut-points defining pediatric hypertension, including the incorporation of absolute cut-points rather than percentiles for adolescents. Objective: To evaluate the impact of the new CPG (compared with the 4 th Report) on the prevalence of hypertension and associations with cardiovascular risk factors (CVRFs) and target organ damage (TOD) in a population of high-risk youth. Methods: Subjects (N=364, 10-18 years) underwent fasting anthropometric, blood pressure (measured as per the Fourth Report), CVRF (lipid profile, insulin, glucose, HbA1C%), carotid artery intima-media thickness (cIMT), pulse wave velocity (PWV), and left ventricular mass and diastolic (via echocardiography) assessments. Blood pressure was categorized as normal, elevated, Stage 1, and Stage 2 hypertension, as defined by the 4 th report and by the new CPG. The agreement between the prevalence of hypertension using the two guidelines and associations with other CVRFs and markers of TOD were evaluated using weighted Kappa statistics and tests of symmetry. Results: Of the 364 subjects (65% female, 15.1 +/- 2.1 years), 36 (10%) had Stage 1 and 11 (3%) had Stage 2 hypertension (as defined by CPG). Hypertension (Stage 1 &amp; 2) was associated with the presence of other CVRFs and TOD (Table). With respect to hypertension prevalence distribution, the 4 th Report and CPG produced only a moderate agreement (weighted kappa 0.82 (95% CI 0.78, 0.86)) with a significant departure from perfect agreement (test of symmetry p &lt;0.001). Similar findings were noted for associations with other CVRFs and markers of TOD (Table). Conclusions: The 4 th Report and CPG produced asymmetric blood pressure category distributions and associations with CVRFs and TOD. This finding should be considered when using the CPG in clinical and academic settings, and warrants further evaluation.
Earthquake in Turkey
Authors: Devaraj A Supramaniam
Journal: BMJ (1999)

I was on call on the psychiatric ward that night, asleep in the house officer\'s room, when suddenly I felt myself being shaken violently awake. Half asleep, I strained to hear if any of the patients had been disturbed as well. Not hearing anything, I turned around and went back to bed, thinking that it must have been another one of those mild earthquakes that strikes Ankara on and off. In the morning, I woke up to find that the electricity and water had been cut and the duty nurse was looking very distressed. She had heard over the radio that a large earthquake had hit the northwestern part of Turkey and that there was some damage. It wasn't until much later in the day that the magnitude and scale of the earthquake became clear.

In the evening news, pictures from the affected areas started coming in. They showed city after city with buildings either reduced to piles of rubble or floors stacked upon each other like giant concrete pancakes, with no sign of the supporting pillars. Almost anything else left standing was either tilting precariously or sitting on its second or third floor with everything else below crushed beyond sight. People were standing around staring in shock, trying to comprehend what had happened or searching the rubble itself frantically for family and loved ones. There didn't seem to be any professional help of …
An improved ileal conduit surgery for bladder cancer with fewer complications
Authors: Zhiyong Li, Zhuowei Liu, Kai Yao, Zike Qin, Hui Han, Yonghong Li, Pei Dong, Yunlin Ye, Yanjun Wang, Zhiming Wu, Zhiling Zhang, Fangjian Zhou
Journal: Cancer Communications (2019)

Radical cystectomy and urinary diversion remains the standard surgical treatment for patients with muscle-invasive or high-risk or recurrent non-muscle-invasive bladder cancer. Although this approach prolongs patient survival remarkably, there are postoperative complications associated with urinary diversion. This study aimed to assess the efficacy of modified ileal conduit surgery for reducing early and late stoma- and ureteroileal anastomosis-related complications, as compared with conventional ileal conduit urinary diversion.
SETD2 mutations confer chemoresistance in acute myeloid leukemia partly through altered cell cycle checkpoints
Authors: Yunzhu Dong, Xinghui Zhao, Xiaomin Feng, Yile Zhou, Xiaomei Yan, Ya Zhang, Jiachen Bu, Di Zhan, Yoshihiro Hayashi, Yue Zhang, Zefeng Xu, Rui Huang, Jieyu Wang, Taoran Zhao, Zhijian Xiao, Zhenyu Ju, Paul R. Andreassen, Qian-fei Wang, Wei Chen, Gang Huang
Journal: Leukemia (2019)
Efficacy, safety, and pharmacokinetics of emicizumab prophylaxis given every 4 weeks in people with haemophilia A (HAVEN 4): a multicentre, open-label, non-randomised phase 3 study
Authors: Steven W Pipe, Midori Shima, Michaela Lehle, Amy Shapiro, Sammy Chebon, Katsuyuki Fukutake, Nigel S Key, Agnès Portron, Christophe Schmitt, Maria Podolak-Dawidziak, Nives Selak Bienz, Cedric Hermans, Avrita Campinha-Bacote, Anna Kiialainen, Kathelijne Peerlinck, Gallia G Levy, Victor Jiménez-Yuste
Journal: The Lancet Haematology (2019)
Some Aspects of the Problem of Regulation of Food Intake and Obesity
Authors: Jean Mayer
Journal: New England Journal of Medicine (1966)

Treatment of ObesityImportance of Medical History of ObesityIt goes without saying that the medical history must pay particular attention to the age at onset of obesity and its past course: the psychologic aspects and prognosis are quite different in persons who become obese in their adult years and in those who were obese as children and adolescents. Persons who were obese as youngsters are much more likely to be obsessively concerned with self-image and to view their obesity as a badge of shame rather than as a medical problem that can be attacked by rather simple means; they . . .
Abstract 18551: Multivariate Predictors of Subclinical Lower Extremity Peripheral Artery Disease in Mexican Americans: Results From the Cameron County Hispanic Cohort Study
Authors: Nelson D Gonzalez, Marlene Garcia, Kristina P Vatcheva, Audrey Choh, Gordon Watt, Susan T Laing, Joseph B McCormick, Susan Fisher-Hoch, Anand Prasad
Journal: Circulation (2017)

Background: Risk factors for subclinical lower extremity peripheral arterial disease (PAD) in Mexican Americans (MA) have not been well characterized. The aim of this study was to ascertain the multivariate predictors of subclinical PAD in a random population sample of MA adults in Cameron County, Texas. Methods: The Cameron County Hispanic Cohort Study is a prospective population-based cohort that assesses demographic and clinical characteristics from MA households in Cameron County, Texas. In addition to a detailed clinical history and exam, the subjects underwent measurement of bilateral ankle and toe brachial indices (ABI, TBI) using a Doppler system. The higher and lower of the two pedal pressures for each limb were used for calculating ABI-High and ABI-Low, respectively. Both pedal pressures were divided by the higher of the two brachial pressures. TBI was determined by photoplethysmographic technique. Multivariable logistic regression models were used to analyze the relationship between PAD and cli...
PS-043-Dual targeting of G9a and DNM-methyltransferase-1 for the treatment of experimental cholangiocarcinoma
Authors: Leticia Colyn, Gloria Álvarez-Sola, Maria U Latasa, Iker Uriarte, Marina Bárcena-Varela, Maria Arechederra, Maddalen Jimenez, Sergio Morini, Simone Carotti, Julen Oyarzabal, Felipe Prosper, Matteo Canale, Andrea Casadei Gardini, Maria Iraburu Elizalde, Jesus Urman, Chaobo Chen, Francisco Javier Cubero, Leonard J Nelson, Bruno Sangro, María Luz Martínez-Chantar, Jesús María Banales, Jose Marin, Carmen Berasain, Maite G Fernandez-Barrena, Matías A Avila
Journal: Journal of Hepatology (2019)
SAT-185-Is the performance of ultra-sensitive HBsAg Fujirebio assay consistent across HBV genotypes (comparison between CLEIA HBsAg HQ Fujirebio and Abbott Architect assays)
Authors: Christiana Moigboi, Matthew Bruce, Mary Horner, Geoffrey Dusheiko, Kosh Agarwal, Ivana Carey
Journal: Journal of Hepatology (2019)
Subclassification of prostate cancer circulating tumor cells (CTCs) by nuclear size reveals very-small nuclear CTCs in patients with visceral metastases.
Authors: Yi-Tsung Lu, Jie-Fu Chen, Hao Ho, Jake Lichterman, Leland WK Chung, Ker-Chau Li, Zunfu Ke, Hsian-Rong Tseng, Edwin M. Posadas
Journal: Journal of Clinical Oncology (2015)

11027 Background: In prostate cancer (PCa), morphologic classification remains a standard clinical practice in pathology. It has been shown that nuclear size and shape in tumor sections correlate with distant metastasis and death, but this relationship has not been explored in emerging tissue sources such as CTCs. Using NanoVelcro chip, our group sub-classified CTCs in PCa patients by shape features focusing on nuclear size and related this to clinical information, particularly the lethal progression to visceral metastasis (VM). Methods: A total of 148 blood samples were obtained from 57 PCa patients across the spectrum of metastatic states: no metastases, non-visceral (osseous and/or nodal) metastases, and visceral (hepatic and/or pulmonary) metastases. CTCs captured and enumerated on NanoVelcro Chips were subjected to pathologic review including nuclear size. The distribution of nuclear size was analyzed using a Gaussian Mixture Model. Correlations were made between CTC subsets and metastatic status. Results: Statistical modeling of nuclear size distribution revealed 3 distinct subsets: large-nuclear ( > 15 µm), small-nuclear (snCTCs, 8.54 - 15 µm), and very-small-nuclear CTCs (vsnCTCs, < 8.54 µm). The proportions of the 3 CTC nuclear subsets varied significantly among different metastatic states (p < 0.001). snCTC + vsnCTC identified patients with metastatic disease from those without (0.35 ± 0.66 versus 2.02 ± 3.36 cells per mL of blood, p < 0.001). vsnCTC counts alone were elevated in patients with VM when compared to those without (0.36 ± 0.69 vs. 1.95 ± 3.77 cells/mL blood, p < 0.001). Serial enumerations suggested the emergence of vsnCTCs prior to radiographic detection of newly developed VM. Conclusions: There are morphologic subsets of CTCs that can be identified by fundamental pathologic approaches, such as nuclear size measurement. Our observation strongly suggests that they contain relevant information on disease status. In particular, the detection of vsnCTCs correlated with the presence of VM and should be explored as a putative blood-borne biomarker to identify patients at risk for developing this lethal progression event of PCa.
THU-144-Ledipasvir/sofosbuvir for 8, 12, or 24 weeks is safe and effective in patients undergoing dialysis
Authors: Wan-Long Chuang, Tsung-Hui Hu, Peter Buggisch, Christophe Moreno, Wei-Wen Su, Luigi Biancone, Robert Hyland, Sophia Lu, Svetlana Markova, Hadas Dvory-Sobel, Anu Osinusi, Anuj Gaggar, Cheng-Yuan Peng, Chen-Hua Liu, Meghan Sise, Alessandra Mangia
Journal: Journal of Hepatology (2019)