Werner's Syndrome
Authors: CHARLES J. EPSTEIN
Journal: Annals of Internal Medicine (1965)

Editorial1 August 1965Werner's SyndromeCHARLES J. EPSTEIN, M.D.CHARLES J. EPSTEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-2-343 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn his classic review on Werner's syndrome published in the ANNALS in 1945, Thannhauser (1) was the first to define clearly the essential features of the syndrome and to distinguish it from other conditions (such as scleroderma and Rothmund's syndrome) with which it had been confused. The principal characteristics, as first described by Werner in 1904 (2) and expanded by Thannhauser and others (1, 3-6), are [1] shortness of stature, [2] cataracts, [3] skin changes affecting mainly the legs and consisting of atrophy, tightening, hyperkeratoses, and ulcers, [4] premature graying and loss of hair, and [5] atrophy of the muscle,...References1. THANNHAUSER SJ: Werner's syndrome (progeria of the adult) and Rothmund's syndrome: two types of closely related heredofamilial atrophic dermatosis with juvenile cataracts and endocrine features. A critical study with five new cases. Ann. Intern. Med. 23: 559, 1945. LinkGoogle Scholar2. WERNER O: Über Katarakt in Verbindung mit Sklerodermie. (Doctoral dissertation), Kiel University, 1904. Google Scholar3. OPPENHEIMERKUGEL BSVH: Werner's syndrome—a heredofamilial disorder with scleroderma, bilateral juvenile cataract, precocious graying of hair and endocrine stigmatization. Trans. Ass. Amer. Physicians 49: 358, 1934. Google Scholar4. JACOBSONRIFKINZUCKER-FRANKLIN HGHD: Werner's syndrome: a clinical-roentgenological entity. Radiology 74: 373, 1960. CrossrefMedlineGoogle Scholar5. KNOWTHBAETHKEHOFFMANN WRL: Über das Werner-Syndrom. Ein Beitrag zur Kenntnis der Schilddrüsenfunktion nach Radiojodstudium, der Symptomatologie der Schrifttumsfälle und der histologischen Differentialdiagnose zum Rothmund-Syndrom. Hautarzt 14: 145, 193, 1963. MedlineGoogle Scholar6. EPSTEINMARTINSCHULTZMOTULSKY CJGMALAG: Werner's syndrome: an analytical review of its symptomatology, natural history, pathologic features, genetics and its relationship to the natural aging process. Submitted for publication. Google Scholar7. BOYDGRANT MWAP: Werner's syndrome (progeria of the adult). Further pathological and biochemical observations. Brit. Med. J. 2: 920, 1959. CrossrefMedlineGoogle Scholar8. PETROHELOS M: Werner's syndrome: a survey of three cases, with review of the literature. Amer. J. Ophthal. 56: 941, 1963. CrossrefMedlineGoogle Scholar9. MUELLERSORENSONSTRANDFORDKAPPAS MNLBNA: Alkaptonuria and ochronotic arthropathy. Med. Clin. N. Amer. 49: 101, 1965. CrossrefGoogle Scholar10. CASARETT GW: Similarities and contrasts between radiation and time pathology. Adv. Gerontol. Res. 1: 109, 1964. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CHARLES J. EPSTEIN, M.D.Affiliations: National Institute of Arthritis an Metabolic Diseases National Institutes of Health Bethesda, Md. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1965Volume 63, Issue 2Page: 343-345KeywordsAtrophyCataractsMusclesSclerodermaUlcers ePublished: 1 December 2008 Issue Published: 1 August 1965 PDF downloadLoading ...