tbuckley/cabot-search huggingface dataset:
Genomics of circadian rhythms in health and disease
Authors: Filipa Rijo-Ferreira, Joseph S. Takahashi
Journal: Genome Medicine (2019)

Abstract Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral processes. The central circadian clock exerts control over myriad aspects of mammalian physiology, including the regulation of sleep, metabolism, and the immune system. Here, we review advances in understanding the genetic regulation of sleep through the circadian system, as well as the impact of dysregulated gene expression on metabolic function. We also review recent studies that have begun to unravel the circadian clock’s role in controlling the cardiovascular and nervous systems, gut microbiota, cancer, and aging. Such circadian control of these systems relies, in part, on transcriptional regulation, with recent evidence for genome-wide regulation of the clock through circadian chromosome organization. These novel insights into the genomic regulation of human physiology provide opportunities for the discovery of improved treatment strategies and new understanding of the biological underpinnings of human disease.
A Single Dose of CD117 Antibody Drug Conjugate Enables Autologous Gene-Modified Hematopoietic Stem Cell Transplant (Gene Therapy) in Nonhuman Primates
Authors: John F. Tisdale, Robert E. Donahue, Naoya Uchida, Bradley R Pearse, Sean M McDonough, Jennifer L Proctor, Allen Krouse, Nathaniel S. Linde, Aylin C. Bonifacino, Rajiv Panwar, Ganapathy N. Sarma, Lena Kien, Kellie Latimer, Junia Dushime, Sharon L. Hyzy, Melissa L. Brooks, Rahul Palchaudhuri, Qing Li, Pranoti Sawant, Charlotte F McDonagh, Anthony E. Boitano, Michael P. Cooke
Journal: Blood (2019)
Abstract 15767: Associations Between Amygdalar Activity and the Subsequent Development of Takotsubo Syndrome: Novel Mechanistic Insights
Authors: Azar Radfar, Ying Wang, Michael T. Osborne, Tomas Patrich, Brian Tung, Blake Oberfeld, Tomas Neilan, Malissa Wood, Ahmed Tawakol
Journal: Circulation (2018)

Introduction: Takotsubo syndrome (TTS) is an acute, usually transient heart failure syndrome that typically occurs as a consequence of an acute emotional or physical stressor. The amygdala is a reg...
Nivolumab treatment beyond progression disease in advanced non-small cell lung cancer
Authors: T. Enomoto, A. Tamiya, K. Matsumoto, Y. Adachi, K. Azuma, Y. Inagaki, S. Kouno, Y. Taniguchi, N. Saijo, K. Okishio, S. Atagi
Journal: Annals of Oncology (2019)
Corrigendum to “Untangling the response of bone tumor cells and bone forming cells to matrix stiffness and adhesion ligand density by means of hydrogels” [Biomaterials 188 (2019) 130–143]
Authors: Tongmeng Jiang, Jinmin Zhao, Shan Yu, Zhengwei Mao, Changyou Gao, Ye Zhu, Chuanbin Mao, Li Zheng
Journal: Biomaterials (2019)
Drastic Response of Rechallenge of Nivolumab in a Patient with NSCLC Who Progressed on the First Nivolumab Treatment
Authors: Satoshi Hirano, Nami Hayama, Hiroshi Tabeta, Tsuguko Kuroki, Yuka Shiraishi, Tetsuo Fujita, Hiroyuki Amano, Makoto Nakamura, Shinichiro Shimizu, Sukeyuki Nakamura
Journal: Journal of Thoracic Oncology (2019)
Abstract P347: Association Between Sleep Patterns and the American Heart Association Life’s Simple 7 Among Women
Authors: Nour Makarem, Marie-Pierre St-Onge, Ming Liao, Brooke Aggarwal
Journal: Circulation (2018)

Introduction: The American Heart Association’s Life’s Simple 7 (AHA LS7) is a measure of cardiovascular health that evaluates seven lifestyle behaviors and clinical risk factors to track the population’s progress towards the AHA 2020 strategic goals. Sleep is an emerging lifestyle risk factor for cardiovascular disease that is not currently included in the AHA LS7. Our aim was to assess the relation of sleep with the AHA LS7 within a diverse sample of women. Hypothesis: We hypothesized that a longer sleep duration, good sleep quality, low risk for obstructive sleep apnea (OSA), and absence of insomnia and snoring would be associated with a higher global AHA LS7 score and its component scores, as measures of compliance to overall and individual AHA LS7 guidelines. Methods: Baseline data from the AHA Go Red for Women Strategically Focused Research Network cohort at Columbia University Medical Center, an ongoing prospective study, were examined (n=323, &gt;50% minority/Hispanic, mean age: 39y, range: 20-76y). Sleep was self-reported using validated questionnaires. A standardized scoring system was used to compute the global AHA LS7 score using criteria for smoking, diet, physical activity, body mass index (BMI), blood pressure (BP), total cholesterol, and fasting glucose. Women received a score of 2 (optimal), 1 (average), or 0 (poor) based on their compliance with each AHA LS7 guideline. The seven component scores were summed to create the global AHA LS7 score. T-tests, Fischer’s exact test and multivariable-adjusted regression models were used to evaluate associations between sleep and the global AHA LS7 score and its components. Results: The median global AHA LS7 score was 10; 31.3%, 33.3% and 35.3% of women had a score of 0-8 (poor), 9-10 (average), and 11-14 (optimal), respectively. Participants with sleep duration ≥7 hours, lack of insomnia and snoring, and low risk for OSA were more likely to meet ≥4 of the AHA LS7 metrics (p≤0.04). Those with sleep duration ≥7 hours, good sleep quality, no insomnia and snoring, and at low risk of OSA were more likely to meet the AHA LS7 optimal guideline for physical activity, BMI, BP, glucose, and cholesterol (p≤0.04). In multivariable-adjusted linear regression models, a lower global AHA LS7 score was associated with a higher Pittsburgh Sleep Quality Index, indicative of poorer sleep quality (β=-0.08, p=0.019), higher insomnia severity index (β=-0.05, p=0.027), and higher risk for OSA (β=-0.84, p=0.016). Conclusions: In this cohort of women, better sleep habits were associated with meeting the AHA LS7 guidelines. Our results warrant confirmation in larger prospective studies and within other population groups, but nonetheless highlight the potential importance of screening for sleep habits in conjunction with other lifestyle behaviors to identify those at risk of cardiovascular disease.
Kindergarten Vaccine Coverage Needs a Boost
Authors: Bridget Kuehn
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Host‐microbe interactions: Profiles in the transcriptome, the proteome, and the metabolome
Authors: Trang Nguyen, Lea Sedghi, Sean Ganther, Erin Malone, Pachiyappan Kamarajan, Yvonne L. Kapila
Journal: Periodontology 2000 (2019)

Abstract Periodontal studies using transcriptomics, proteomics, and metabolomics encompass the collection of mRNA transcripts, proteins, and small‐molecule chemicals in the context of periodontal health and disease. The number of studies using these approaches has significantly increased in the last decade and they have provided new insight into the pathogenesis and host‐microbe interactions that define periodontal diseases. This review provides an overview of current molecular findings using ‐omic approaches that underlie periodontal disease, including modulation of the host immune response, tissue homeostasis, and complex metabolic processes of the host and the oral microbiome. Integration of these ‐omic approaches will broaden our perspective of the molecular mechanisms involved in periodontal disease, advancing and improving the diagnosis and treatment of various stages and forms of periodontal disease.
Recorded diagnosis of NAFLD and the risk of incident acute myocardial infarction and stroke: findings from matched cohort study of 18 million European adults
Authors: M Alexander, A K Loomis, J van der Lei, T Duarte-Salles, D Prieto Alhambra, D Ansell, A Pasqua, F Lapi, P Rijnbeek, M Mosseveld, P Avillach, P Egger, N N Dhalwani, S Kendrick, C Celis-Morales, W Alazawi, N Sattar
Journal: BMJ (2019)
Sarcopenia in Older Adults Undergoing Transcatheter Aortic Valve Replacement
Authors: Samuel Mamane, Louis Mullie, Wayne Lok Ok Choo, Nicolo Piazza, Giuseppe Martucci, José A. Morais, Dae H. Kim, Sandra Lauck, John G. Webb, Jonathan Afilalo
Journal: Journal of the American College of Cardiology (2019)
US Geographical Variation in Rates of Shoulder and Knee Arthroscopy and Association With Orthopedist Density
Authors: Nitin B. Jain, Emily Peterson, Gregory D. Ayers, Amos Song, John E. Kuhn
Journal: JAMA Network Open (2019)

<h3>Importance</h3> Although rates of arthroscopy have substantially increased, recent data question its comparative effectiveness. <h3>Objectives</h3> To assess time trends and geographical variations among several US states in arthroscopy rates and to assess the association of orthopedist density with arthroscopy rates. <h3>Design, Setting, and Participants</h3> In this cross-sectional study, procedure rates were calculated for knee arthroscopy, shoulder arthroscopy, and arthroscopic rotator cuff repair using data from the State Ambulatory Surgery and Services Databases for 2006 to 2016 (as available) for the states of California, Colorado, Florida, Iowa, Kentucky, Maryland, Maine, Michigan, Minnesota, North Carolina, Nebraska, New Jersey, Nevada, New York, Oregon, Utah, Vermont, and Wisconsin. Data were analyzed from June 2017 to October 2019. <h3>Main Outcomes and Measures</h3> Rates of knee arthroscopy, shoulder arthroscopy, and arthroscopic rotator cuff repair. <h3>Results</h3> The combined data sets included 4 856 385 records with 2 530 840 female patients (47%); mean (SD) patient age was 49.13 (16.34) years. Rates per 100 000 persons showed large geographical variations for knee arthroscopy (from 63.31 [95% CI, 5.92-198.95] to 721.72 [95% CI, 633.41-806.20]), shoulder arthroscopy (from 53.02 [95% CI, 2.80-164.36] to 438.25 [95% CI, 399.00-476.78]), and arthroscopic rotator cuff repair (from 11.94 [95% CI, 1.30-56.98] to 185.35 [95% CI, 143.84-226.20]) across US states and years. There were significant downward time trends in knee arthroscopy rates in California, Florida, Iowa, Maryland, Michigan, Nebraska, and New Jersey and upward trends for arthroscopic rotator cuff repair in Colorado, Florida, Kentucky, Maine, and North Carolina. Orthopedist density was not associated with knee arthroscopy rates (slope = 3.07; 95% CI, −9.88 to 16.03;<i>P</i> = .54), shoulder arthroscopy rates (slope = 2.74; 95% CI, −6.53 to 12.01;<i>P</i> = .47), or rates of arthroscopic rotator cuff repair (slope = 1.15; 95% CI, −2.77 to 5.05;<i>P</i> = .49). <h3>Conclusions and Relevance</h3> There is large geographical variation in arthroscopy rates despite the questionable comparative effectiveness of these procedures. The reasons for increasing rates of rotator cuff surgery should be further examined.
Using Selection by Nonantibiotic Stressors to Sensitize Bacteria to Antibiotics
Authors: Jeff Maltas, Brian Krasnick, Kevin B Wood
Journal: Molecular Biology and Evolution (2019)

Evolutionary adaptation of bacteria to nonantibiotic selective forces, such as osmotic stress, has been previously associated with increased antibiotic resistance, but much less is known about potentially sensitizing effects of nonantibiotic stressors. In this study, we use laboratory evolution to investigate adaptation of Enterococcus faecalis, an opportunistic bacterial pathogen, to a broad collection of environmental agents, ranging from antibiotics and biocides to extreme pH and osmotic stress. We find that nonantibiotic selection frequently leads to increased sensitivity to other conditions, including multiple antibiotics. Using population sequencing and whole-genome sequencing of single isolates from the evolved populations, we identify multiple mutations in genes previously linked with resistance to the selecting conditions, including genes corresponding to known drug targets or multidrug efflux systems previously tied to collateral sensitivity. Finally, we hypothesized based on the measured sensitivity profiles that sequential rounds of antibiotic and nonantibiotic selection may lead to hypersensitive populations by harnessing the orthogonal collateral effects of particular pairs of selective forces. To test this hypothesis, we show experimentally that populations evolved to a sequence of linezolid (an oxazolidinone antibiotic) and sodium benzoate (a common preservative) exhibit increased sensitivity to more stressors than adaptation to either condition alone. The results demonstrate how sequential adaptation to drug and nondrug environments can be used to sensitize bacteria to antibiotics and highlight new potential strategies for exploiting shared constraints governing adaptation to diverse environmental challenges.
Donor-derived bacterial infections in lung transplant recipients in the era of multidrug resistance
Authors: Eleonora Bunsow, Ibai Los-Arcos, María Teresa Martin-Gómez, Irene Bello, Teresa Pont, Cristina Berastegui, Ricard Ferrer, Xavier Nuvials, María Deu, Maddalena Peghin, Juan José González-López, Mayli Lung, Antonio Román, Joan Gavaldà, Oscar Len
Journal: Journal of Infection (2019)
Hospital-Level Care at Home for Acutely Ill Adults
Authors: David M. Levine, Kei Ouchi, Bonnie Blanchfield, Agustina Saenz, Kimberly Burke, Mary Paz, Keren Diamond, Charles T. Pu, Jeffrey L. Schnipper
Journal: Annals of Internal Medicine (2019)

Substitutive hospital-level care in a patient's home may reduce cost, health care use, and readmissions while improving patient experience, although evidence from randomized controlled trials in the United States is lacking.To compare outcomes of home hospital versus usual hospital care for patients requiring admission.Randomized controlled trial. (ClinicalTrials.gov: NCT03203759).Academic medical center and community hospital.91 adults (43 home and 48 control) admitted via the emergency department with selected acute conditions.Acute care at home, including nurse and physician home visits, intravenous medications, remote monitoring, video communication, and point-of-care testing.The primary outcome was the total direct cost of the acute care episode (sum of costs for nonphysician labor, supplies, medications, and diagnostic tests). Secondary outcomes included health care use and physical activity during the acute care episode and at 30 days.The adjusted mean cost of the acute care episode was 38% (95% CI, 24% to 49%) lower for home patients than control patients. Compared with usual care patients, home patients had fewer laboratory orders (median per admission, 3 vs. 15), imaging studies (median, 14% vs. 44%), and consultations (median, 2% vs. 31%). Home patients spent a smaller proportion of the day sedentary (median, 12% vs. 23%) or lying down (median, 18% vs. 55%) and were readmitted less frequently within 30 days (7% vs. 23%).The study involved 2 sites, a small number of home physicians, and a small sample of highly selected patients (with a 63% refusal rate among potentially eligible patients); these factors may limit generalizability.Substitutive home hospitalization reduced cost, health care use, and readmissions while increasing physical activity compared with usual hospital care.Partners HealthCare Center for Population Health and internal departmental funds.
Allele Frequency–Adjusted Blood-Based Tumor Mutational Burden as a Predictor of Overall Survival for Patients With NSCLC Treated With PD-(L)1 Inhibitors
Authors: Zhijie Wang, Jianchun Duan, Guoqiang Wang, Jing Zhao, Jiachen Xu, Jiefei Han, Zhengyi Zhao, Jun Zhao, Bo Zhu, Minglei Zhuo, Jianguo Sun, Hua Bai, Rui Wan, Xin Wang, Kailun Fei, Shuhang Wang, Xiaochen Zhao, Yuzi Zhang, Mengli Huang, Depei Huang, Chuang Qi, Chan Gao, Yuezong Bai, Hua Dong, Lei Xiong, Yanhua Tian, Di Wang, Chunwei Xu, Wenxian Wang, Junling Li, Xingsheng Hu, Shangli Cai, Jie Wang
Journal: Journal of Thoracic Oncology (2019)
Interim effect evaluation of the hepatitis C elimination programme in Georgia: a modelling study
Authors: Josephine G Walker, Tinatin Kuchuloria, David Sergeenko, Hannah Fraser, Aaron G Lim, Shaun Shadaker, Liesl Hagan, Amiran Gamkrelidze, Valeri Kvaratskhelia, Lia Gvinjilia, Malvina Aladashvili, Alexander Asatiani, Davit Baliashvili, Maia Butsashvili, Ivdity Chikovani, Irma Khonelidze, Irma Kirtadze, Mark H Kuniholm, David Otiashvili, Lali Sharvadze, Ketevan Stvilia, Tengiz Tsertsvadze, Mamuka Zakalashvili, Matthew Hickman, Natasha K Martin, Juliette Morgan, Muazzam Nasrullah, Francisco Averhoff, Peter Vickerman
Journal: The Lancet Global Health (2019)

Georgia has a high prevalence of hepatitis C, with 5·4% of adults chronically infected. On April 28, 2015, Georgia launched a national programme to eliminate hepatitis C by 2020 (90% reduction in prevalence) through scaled-up treatment and prevention interventions. We evaluated the interim effect of the programme and feasibility of achieving the elimination goal.
Understanding the Consequences of Eliminating Copayments for Skin Cancer Screening
Authors: Kanade Shinkai
Journal: JAMA Dermatology (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Not only synovitis but also tenosynovitis needs to be considered: why it is time to update textbook images of rheumatoid arthritis
Authors: Cleo Rogier, Silvia Hayer, Annette van der Helm-van Mil
Journal: Annals of the Rheumatic Diseases (2019)

RoW: computer programmer for the QUARTZ group.AR: data analyst for generating vasculometric measures from QUARTZ derived measures of pixel width.TP:
Abstract A15: Elucidating the role of p53 in the cellular origins of pancreatic cancer development
Authors: Brittany M. Flowers, Hang Xu, Kathryn Hanson, Christina Curtis, Hannes Vogel, Laura D. Wood, Laura D. Attardi
Journal: Cancer Research (2019)

Abstract The tumor suppressor gene TP53 encodes a transcriptional activator critical for suppressing pancreatic ductal adenocarcinoma (PDAC). TP53 mutations, which are most frequently missense mutations in the DNA binding domain, result in both loss of wild-type p53 function and gain of novel, oncogenic functions. Mouse models of PDAC relying on oncogenic Kras and p53 mutation have suggested that either pancreatic acinar or ductal cells, the two major epithelial cell types in the pancreas, may be the cell of origin for PDAC, although there is very limited understanding of the molecular pathways through which p53 mutations contribute to PDAC driven by oncogenic Kras. Moreover, the cellular functions of p53 involved in tumor suppression remain enigmatic. To set up a platform for deconstructing p53 loss-of-function (LOF) and gain-of-function (GOF) pathways, we have generated mouse models to study p53 function in adult mice, mimicking the context of human cancer, using tamoxifen-inducible Cre recombinases to activate Kras (KrasLSL-G12D) in adult mouse pancreatic acinar (Ptf1aCreER) and ductal (Sox9CreER) compartments, in the backdrop of different p53 alleles. To investigate p53 LOF, we generated mouse cohorts with wild-type p53 expression or conditional p53 knockout (p53fl/fl). To examine p53 GOF, we generated mouse cohorts with conditional expression of structural mutant p53R172H (p53LSL-R172H/fl), contact mutant p53R270H (p53LSL-R270H/fl) and conditional p53 knockout (p53null/fl) for comparison in a uniform p53 heterozygous genetic background of stromal tissues. Our tumor studies have demonstrated that oncogenic Kras expression and p53 knockout or mutation in acinar cells of adult mice leads to metastatic PDAC development with complete penetrance. This suggests a novel role for p53 in tumor suppression by blocking cellular reprogramming of acinar cells to ductal-like cells. In contrast, these mutations drive PDAC from ductal cells less efficiently. To understand the origins of human PDAC, we are investigating the molecular pathways altered in mouse acinar and ductal cell-derived tumors. Through comparison with human pancreatic cancer data, our studies will elucidate the cellular origins of different molecular subtypes of human PDAC. Elucidating the mechanisms of PDAC development is critical to improving detection and therapy in PDAC patients. Citation Format: Brittany M. Flowers, Hang Xu, Kathryn Hanson, Christina Curtis, Hannes Vogel, Laura D. Wood, Laura D. Attardi. Elucidating the role of p53 in the cellular origins of pancreatic cancer development [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer: Advances in Science and Clinical Care; 2019 Sept 6-9; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2019;79(24 Suppl):Abstract nr A15.
Biventricular Dysfunction in Patients After Bone Marrow Transplant
Authors: Tejas Deshmukh, MBBS, MClinTRes, Paul Geenty, MBBS, Lucy Geraghty, MBBS, David Emmerig, MBBS, Shanthosh Sivapathan, MBBS, MPH, Megan Hogg, Paula Brown, Shyam Panicker, MBBS, Mikhail Altman, MD, DDU, PhD, David Gottlieb, MBBS, PhD, Liza Thomas, MBBS, PhD
Journal: JACC CardioOncology (2019)

Cardiovascular events are a significant cause of morbidity and mortality in cancer survivors in the long-term. Anthracyclines (AC) are powerful cytotoxic agents, used to treat a wide spectrum of hematologic malignancies and solid tumors. However, 5% to 23% of patients develop late-onset heart
Infographic. How does exercise treatment compare with antihypertensive medications?
Authors: Adrián Castillo-Garcia, Huseyin Naci, Pedro L Valenzuela, Maximilian Salcher-Konrad, Sofia Dias, Manuel R Blum, Samali Anova Sahoo, David Nunan, Javier S Morales, Alejandro Lucia, John PA Ioannidis
Journal: British Journal of Sports Medicine (2019)

of Infographic.How does exercise treatment compare with antihypertensive medications?.