Altered Risk for Cardiovascular Events With Changes in the Metabolic Syndrome Status
Authors: Sehoon Park, Kyungdo Han, Dong Ki Kim
Journal: Annals of Internal Medicine (2020)

Letters19 May 2020Altered Risk for Cardiovascular Events With Changes in the Metabolic Syndrome StatusSehoon Park, MD, Kyungdo Han, PhD, and Dong Ki Kim, MD, PhDSehoon Park, MDSeoul National University College of Medicine, Seoul, Korea (S.P., D.K.K.), Kyungdo Han, PhDSoongsil University, Seoul, Korea (K.H.), and Dong Ki Kim, MD, PhDSeoul National University College of Medicine, Seoul, Korea (S.P., D.K.K.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L20-0076 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:As Dr. Finucane notes, the DCCT studied patients with type 1 diabetes and the original study report published in 1993 did not show any benefits of tight glycemic control on cardiovascular outcomes (1). However, after extended follow-up, it was shown that tight glycemic control in the DCCT did reduce the risk for acute myocardial infarction, stroke, or death from cardiovascular diseases (2). As such, we believe that this trial does suggest that controlling impaired glucose tolerance benefits cardiovascular health. Nevertheless, the included participants had different characteristics from those in our study and the results in patients with type ...References1. Nathan DM, Genuth S, Lachin J, et al; Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329:977-986. [PMID: 8366922] CrossrefMedlineGoogle Scholar2. Nathan DM, Cleary PA, Backlund JY, et al; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med. 2005;353:2643-2653. [PMID: 16371630] CrossrefMedlineGoogle Scholar3. Chiasson JL, Josse RG, Gomis R, et al; STOP-NIDDM Trial Research Group. Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial. JAMA. 2003;290:486-494. [PMID: 12876091] CrossrefMedlineGoogle Scholar4. Gillies CL, Abrams KR, Lambert PC, et al. Pharmacological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance: systematic review and meta-analysis. BMJ. 2007;334:299. [PMID: 17237299] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Seoul National University College of Medicine, Seoul, Korea (S.P., D.K.K.)Soongsil University, Seoul, Korea (K.H.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M19-0563. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAltered Risk for Cardiovascular Events With Changes in the Metabolic Syndrome Status Sehoon Park , Soojin Lee , Yaerim Kim , Yeonhee Lee , Min Woo Kang , Kyungdo Han , Seung Seok Han , Hajeong Lee , Jung Pyo Lee , Kwon Wook Joo , Chun Soo Lim , Yon Su Kim , and Dong Ki Kim Altered Risk for Cardiovascular Events With Changes in the Metabolic Syndrome Status Thomas E. Finucane Metrics Cited byAssociation of short-term and long-term weight loss with the risk of major adverse cardiovascular disease: Community-based cohort studyThe Importance of Metabolic Syndrome Status for the Risk of Non-Viral Hepatocellular Carcinoma: A Nationwide Population-Based StudyThe Change in Metabolic Syndrome Status and the Risk of Nonviral Liver Cirrhosis 19 May 2020Volume 172, Issue 10Page: 707-708KeywordsBloodCardiovascular diseasesDisclosureGlucoseGlucose intoleranceMetabolic syndromeMyocardial infarctionType 1 diabetesType 2 diabetesWeight loss ePublished: 19 May 2020 Issue Published: 19 May 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...