tbuckley/cabot-search huggingface dataset:
The association between Zika virus infection and microcephaly in Brazil 2015–2017: An observational analysis of over 4 million births
Authors: Oliver J. Brady, Aaron Osgood-Zimmerman, Nicholas J. Kassebaum, Sarah E. Ray, Valdelaine E. M. de Araújo, Aglaêr A. da Nóbrega, Livia C. V. Frutuoso, Roberto C. R. Lecca, Antony Stevens, Bruno Zoca de Oliveira, José M. de Lima, Isaac I. Bogoch, Philippe Mayaud, Thomas Jaenisch, Ali H. Mokdad, Christopher J. L. Murray, Simon I. Hay, Robert C. Reiner, Fatima Marinho
Journal: PLoS Medicine (2019)

Background In 2015, high rates of microcephaly were reported in Northeast Brazil following the first South American Zika virus (ZIKV) outbreak. Reported microcephaly rates in other Zika-affected areas were significantly lower, suggesting alternate causes or the involvement of arboviral cofactors in exacerbating microcephaly rates. Methods and findings We merged data from multiple national reporting databases in Brazil to estimate exposure to 9 known or hypothesized causes of microcephaly for every pregnancy nationwide since the beginning of the ZIKV outbreak; this generated between 3.6 and 5.4 million cases (depending on analysis) over the time period 1 January 2015–23 May 2017. The association between ZIKV and microcephaly was statistically tested against models with alternative causes or with effect modifiers. We found no evidence for alternative non-ZIKV causes of the 2015–2017 microcephaly outbreak, nor that concurrent exposure to arbovirus infection or vaccination modified risk. We estimate an absolute risk of microcephaly of 40.8 (95% CI 34.2–49.3) per 10,000 births and a relative risk of 16.8 (95% CI 3.2–369.1) given ZIKV infection in the first or second trimester of pregnancy; however, because ZIKV infection rates were highly variable, most pregnant women in Brazil during the ZIKV outbreak will have been subject to lower risk levels. Statistically significant associations of ZIKV with other birth defects were also detected, but at lower relative risks than that of microcephaly (relative risk < 1.5). Our analysis was limited by missing data prior to the establishment of nationwide ZIKV surveillance, and its findings may be affected by unmeasured confounding causes of microcephaly not available in routinely collected surveillance data. Conclusions This study strengthens the evidence that congenital ZIKV infection, particularly in the first 2 trimesters of pregnancy, is associated with microcephaly and less frequently with other birth defects. The finding of no alternative causes for geographic differences in microcephaly rate leads us to hypothesize that the Northeast region was disproportionately affected by this Zika outbreak, with 94% of an estimated 8.5 million total cases occurring in this region, suggesting a need for seroprevalence surveys to determine the underlying reason.
LONGITUDINAL CHANGES IN MEDICATION DOSING AMONG PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION: FROM THE CHAMP-HF REGISTRY
Authors: Stephen Greene, Gregg Fonarow, Adam DeVore, Puza Sharma, Muthiah Vaduganathan, Nancy Albert, Carol Duffy, C. Larry Hill, Kevin McCague, J. Herbert Patterson, John A. Spertus, Laine Thomas, Fredonia Williams, Adrian Hernandez, Javed Butler
Journal: Journal of the American College of Cardiology (2019)
GENDER-SPECIFIC REFERENCE VALUES FOR HIGH-SENSITIVITY CARDIAC TROPONIN T AND I IN WELL-PHENOTYPED HEALTHY INDIVIDUALS AND VALIDITY OF HIGH-SENSITIVITY ASSAY DESIGNATION
Authors: Matthias Mueller-Hennessen, Evangelos Giannitsis, Tanja Zeller, Matthias Aurich, Moritz Biener, Mehrshad Vafaie, Anna-Sophie Schuebler, Marco Ochs, Johannes Riffel, Derliz Mereles, Stefan Blankenberg, Hugo Katus
Journal: Journal of the American College of Cardiology (2019)
COMPARISON OF PERCUTANEOUS CORONARY INTERVENTION VERSUS OPTIMAL MEDICAL THERAPY IN THE TREATMENT OF CORONARY TOTAL OCCLUSION: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
Authors: Mahmoud Barbarawi, Babikir Kheiri, Yazan Zayed, Laith Rashdan, Inderdeep Gakhal, Owais Barbarawi, Ghassan Bachuwa, Mohammad Luay Alkotob, Deepak L. Bhatt
Journal: Journal of the American College of Cardiology (2019)
HIGH-OUTPUT HEART FAILURE AND PULMONARY HYPERTENSION SECONDARY TO UNCORRECTED POPLITEAL ARTERIOVENOUS FISTULA
Authors: Pooja S. Jagadish, Patrick R. Higgins, Qasim M. Mirza, Tai-Hwang M. Fan, Kodangudi B. Ramanathan
Journal: Journal of the American College of Cardiology (2019)
RIOCIGUAT AMELIORATES RIGHT VENTRICULAR FUNCTION ASSESSED BY SPECKLE-TRACKING ECHOCARDIOGRAPHY IN PATIENTS WITH PULMONARY HYPERTENSIONRIOCIGUAT AMELIORATES RIGHT VENTRICULAR FUNCTION ASSESSED BY SPECKLE-TRACKING ECHOCARDIOGRAPHY IN PATIENTS WITH PULMONARY HYPERTENSION
Authors: Mitsushige Murata, Takashi Kawakami, Masaharu Kataoka, Hidenori Moriyama, Takahiro Hiraide, Mai Kimura, Jin Endo, Takashi Kohno, Yuji Itabashi, Keiichi Fukuda
Journal: Journal of the American College of Cardiology (2019)
MUC1-C Integrates Chromatin Remodeling and PARP1 Activity in the DNA Damage Response of Triple-Negative Breast Cancer Cells
Authors: Masaaki Yamamoto, Caining Jin, Tsuyoshi Hata, Yota Yasumizu, Yan Zhang, Deli Hong, Takahiro Maeda, Masaaki Miyo, Masayuki Hiraki, Yozo Suzuki, Kunihiko Hinohara, Hasan Rajabi, Donald Kufe
Journal: Cancer Research (2019)

Abstract The oncogenic MUC1-C protein is overexpressed in triple-negative breast cancer (TNBC) cells and contributes to their epigenetic reprogramming and chemoresistance. Here we show that targeting MUC1-C genetically or pharmacologically with the GO-203 inhibitor, which blocks MUC1-C nuclear localization, induced DNA double-strand breaks and potentiated cisplatin (CDDP)-induced DNA damage and death. MUC1-C regulated nuclear localization of the polycomb group proteins BMI1 and EZH2, which formed complexes with PARP1 during the DNA damage response. Targeting MUC1-C downregulated BMI1-induced H2A ubiquitylation, EZH2-driven H3K27 trimethylation, and activation of PARP1. As a result, treatment with GO-203 synergistically sensitized both mutant and wild-type BRCA1 TNBC cells to the PARP inhibitor olaparib. These findings uncover a role for MUC1-C in the regulation of PARP1 and identify a therapeutic strategy for enhancing the effectiveness of PARP inhibitors against TNBC. Significance: These findings demonstrate that targeting MUC1-C disrupts epigenetics of the PARP1 complex, inhibits PARP1 activity, and is synergistic with olaparib in TNBC cells.
Increasing importance of European lineages in seeding the hepatitis C virus subtype 1a epidemic in Spain
Authors: Ana Belen Pérez, Bram Vrancken, Natalia Chueca, Antonio Aguilera, Gabriel Reina, Miguel García-del Toro, Francisco Vera, Miguel Angel Von Wichman, Juan Ignacio Arenas, Francisco Téllez, Juan A Pineda, Mohamed Omar, Enrique Bernal, Antonio Rivero-Juárez, Elisa Fernández-Fuertes, Alberto de la Iglesia, Juan Manuel Pascasio, Philippe Lemey, Féderico Garcia, Lize Cuypers
Journal: Eurosurveillance (2019)

Background Reducing the burden of the hepatitis C virus (HCV) requires large-scale deployment of intervention programmes, which can be informed by the dynamic pattern of HCV spread. In Spain, ongoing transmission of HCV is mostly fuelled by people who inject drugs (PWID) infected with subtype 1a (HCV1a). Aim Our aim was to map how infections spread within and between populations, which could help formulate more effective intervention programmes to halt the HCV1a epidemic in Spain. Methods Epidemiological links between HCV1a viruses from a convenience sample of 283 patients in Spain, mostly PWID, collected between 2014 and 2016, and 1,317, 1,291 and 1,009 samples collected abroad between 1989 and 2016 were reconstructed using sequences covering the NS3, NS5A and NS5B genes. To efficiently do so, fast maximum likelihood-based tree estimation was coupled to a flexible Bayesian discrete phylogeographic inference method. Results The transmission network structure of the Spanish HCV1a epidemic was shaped by continuous seeding of HCV1a into Spain, almost exclusively from North America and European countries. The latter became increasingly relevant and have dominated in recent times. Export from Spain to other countries in Europe was also strongly supported, although Spain was a net sink for European HCV1a lineages. Spatial reconstructions showed that the epidemic in Spain is diffuse, without large, dominant within-country networks. Conclusion To boost the effectiveness of local intervention efforts, concerted supra-national strategies to control HCV1a transmission are needed, with a strong focus on the most important drivers of ongoing transmission, i.e. PWID and other high-risk populations.
CAUTION IN DEFERRING PERCUTANEOUS CORONARY INTERVENTION TO CULPRIT STENOSIS IN A PATIENT PRESENTING WITH ACUTE CORONARY SYNDROME AND A NON-ISCHEMIC FRACTIONAL FLOW RESERVE
Authors: Muhammad Umar Khalid, Krupa Solanki, Rohan Parikh, Gaby Aoun
Journal: Journal of the American College of Cardiology (2019)
IMPROVEMENT OF VASCULAR RESPONSE TO ISCHEMIA/REPERFUSION INJURY: ROLE OF THE P2Y11 PURINERGIC RECEPTOR
Authors: Marie Piollet, Claudie Lefort, Lauriane Benoist, Stephanie Chadet, Danina Muntean, Oana Duicu, Adrian Sturza, Denis Angoulvant, Fabrice Ivanes
Journal: Journal of the American College of Cardiology (2019)
浅色和深色型皮肤 AD 儿童中的皮肤胶带黏贴
Authors: L. Hulshof, D.P. Hack, Q.C.J. Hasnoe, B. Dontje, I. Jakasa, C. Riethm€uller, W.H.I. McLean, W.M.C. Aalderen, B. Land, S. Kezic, A.B. Sprikkelman, M.A. Middelkamp‐Hup
Journal: British Journal of Dermatology (2019)

特应性皮 炎 (AD, 特应性湿疹) 是一种非常常见的皮肤病, 影响10‐20%的儿童。它影响所有肤色的儿童, 似乎在亚洲儿童和深色型皮肤儿童中更常发生。但是, 大部分研究是对浅色型皮肤儿童实施的。在荷兰阿姆斯特丹实施的这项研究旨在调查深色和浅色型皮肤儿童中 AD 的差异。为了对此进行研究, 研究者们在53 名 0‐12岁的 AD 儿童和 50 名作为对照 (比较) 的儿童中进行了胶带黏贴。胶带黏贴是一种无痛操作, 对于在儿童中实施是理想的, 在操作过程中将一张小的圆形贴纸贴到皮肤上。当去除这一特殊贴纸时, 一薄层皮肤细胞会被粘在贴纸上, 从而让研究者调查皮肤炎症和皮肤屏障的若干方面。作者们发现, 来自浅色和深色皮肤儿童的 AD 皮肤的皮肤炎症水平和类型相似。但是, 他们发现, 这两组的皮肤屏障标志物存在差异。在浅色皮肤儿童中, AD 皮肤中皮肤屏障完好的标志物低于健康儿童皮肤, 而在深色 AD 皮肤中, 这些皮肤屏障标志物与健康深色皮肤并无显著差异。这项研究显示, 深色皮肤和浅色皮肤 AD 儿童在皮肤炎症方面相似, 但在浅色 AD 儿童中, 皮肤屏障功能异常可能在 AD 发生中发挥着额外的作用。这表明, 浅色和深色皮肤中的 AD 有着不同的发生机制。
RACIAL AND GENDER DISPARITIES IN OUTCOMES OF PERCUTANEOUS CORONARY INTERVENTION IN HUMAN IMMUNODEFICIENCY VIRUS PATIENTS
Authors: Adebayo Atanda, Odunayo Olorunfemi, Talal Alzahrani, Olajide Buhari, Gbolahan Ogunbayo, Kelechi O. Weze, Ayman Elbadawi, Ramesh Mazhari, Jonathan Reiner
Journal: Journal of the American College of Cardiology (2019)
EFFECTIVENESS OF PACLITAXEL-COATED BALLOON ANGIOPLASTY FOR DRUG-ELUTING STENT RESTENOSIS IN THE LEFT MAIN CORONARY ARTERY
Authors: Makoto Takamatsu, Arata Sano, Kohei Osakada, Reo Hata, Akimune Kuwayama, Ryosuke Murai, Katsuya Miura, Masanobu Ohya, Takenobu Shimada, Hidewo Amano, Shunsuke Kubo, Masatomo Ozaki, Mituru Yoshino, Koshi Miyake, Yuichi Kawase, Noriyuki Ohashi, Hiroshi Tasaka, Seiji Habara, Hiroyuki Tanaka, Takeshi Maruo, Yasushi Fuku, Harumi Katoh, Tsuyoshi Goto, Kazushige Kadota
Journal: Journal of the American College of Cardiology (2019)
Real World Outcomes with VTD and Cybord Induction Treatment for Transplant Eligible Multiple Myeloma Patients in a Latin American Country. Retrospective Cohort Study from Gamm (Grupo Argentino de Mieloma Multiple)
Authors: Natalia Paola Schutz, Paola Ochoa, Patricio Duarte, Guillermina Remaggi, Sebastian Yantorno, Ariel Corzo, Soledad Zabaljauregui, Claudia Shanley, Sergio Lopresti, Sergio Orlando, Veronica Verri, Luis Dario Quiroga, Carlos García, Vanesa Fernandez, Dorotea Beatriz Fantl
Journal: Blood (2018)
Abstract 354: Accelerated Autophagy is Required for Doxorubicin-induced Oxidative Damage and Cardiomyopathy
Authors: Ashley J Smuder, Oh-Sung Kwon, Erin E Talbert, Demetra D Christou, Jeung-Ki Yoo, Moon-Hyon Hwang, Andreas N Kavazis
Journal: Circulation Research (2018)

Doxorubicin (DOX) is a highly effective chemotherapeutic agent used in the treatment of a broad spectrum of malignancies. However, clinical use of DOX is limited by the risk of severe cardiotoxicity. In patients, the acute onset of cardiomyopathy often precludes chemotherapy treatment, resulting in reduced quality of life and increased morbidity. While the mechanisms by which DOX promotes cardiac dysfunction are not well understood, our previous findings show that intracellular metabolism of DOX elicits mitochondrial reactive oxygen species (ROS) generation, and subsequent activation of the autophagy/lysosomal system. Equally, evidence suggests that elimination of vital cellular organelles and proteins within the cell as a result of pathologically elevated autophagy may in turn stimulate an increase in ROS generation. Therefore, we hypothesize that DOX-induced autophagy promotes cardiac dysfunction as a result of an autophagy-induced increase in oxidative stress in the heart. To prevent elevated activity of the autophagy/lysosomal system, we administered a dominant negative mutation of the autophagy protein ATG5 (rAAV-dnATG5) to female Sprague-Dawley rats via tail vein administration four weeks prior to either DOX (20 mg/kg ip) or saline treatment. Two days following treatment, assessment of cardiac function showed significant alterations to the myocardial performance index and fractional shortening percentage in control, DOX treated animals. These changes corresponded with deficits to mitochondrial respiration, increased mitochondrial ROS emission and increased appearance of autophagic vacuoles within the heart. In contrast, rAAV-dnATG5 administration in DOX treated animals prevented the conjugation of ATG12 to ATG5 thereby reducing autophagosome formation and attenuating cardiac dysfunction. Interestingly, protein expression of the antioxidant enzymes catalase and superoxide dismutase 2 (SOD2) was elevated in these animals, which may account for improved mitochondrial respiration and reduced mitochondrial free radical production. These findings indicate that accelerated autophagy promotes DOX-induced cardiac dysfunction and is an underlying cause of chemotherapy-induced oxidative damage to the heart.
EXCLUSION OF LEFT ATRIAL APPENDAGE THROMBUS WITH DOBUTAMINE INFUSION PRIOR TO CARDIOVERSION IN PATIENTS WITH ATRIAL FIBRILLATION AND DENSE SPONTANEOUS ECHO CONTRAST
Authors: Edward Chu, Daniel Musikantow, Michael Gavalas, David Narotsky, Martin Goldman, Srinivas Dukkipati, Vivek Reddy
Journal: Journal of the American College of Cardiology (2019)
Excess Mortality in Low-Risk MDS Can be Explained By MDS and AML Related Causes of Death
Authors: Krzysztof Madry, Ge Yu, Karol Lis, Pierre Fenaux, David Bowen, Argiris Symeonidis, Moshe Mittelman, Reinhard Stauder, Jaroslav Cermak, Guillermo Sanz, Eva Hellström-Lindberg, Luca Malcovati, Saskia Langemeijer, Ulrich Germing, Mette Skov Holm, Agnès Guerci-Bresler, Dominic Culligan, Laurence Sanhes, Juliet Mills, Ioannis Kotsianidis, Corine van Marrewijk, Simon Crouch, Theo M de Witte, Alexandra Smith
Journal: Blood (2018)
Congenital ichthyoses: European guidelines of care, part two
Authors: J. Mazereeuw‐Hautier, A. Hernández‐Martín, E.A. O'Toole, A. Bygum, C. Amaro, M. Aldwin, A. Audouze, C. Bodemer, E. Bourrat, A. Diociaiuti, M. Dolenc‐Voljč, I. Dreyfus, M. El Hachem, J. Fischer, A. Ganemo, C. Gouveia, R. Gruber, S. Hadj‐Rabia, D. Hohl, N. Jonca, K. Ezzedine, D. Maier, R. Malhotra, M. Rodriguez, H. Ott, D.G. Paige, A. Pietrzak, F. Poot, M. Schmuth, J.C. Sitek, P. Steijlen, G. Wehr, M. Moreen, A. Vahlquist, H. Traupe, V. Oji
Journal: British Journal of Dermatology (2019)

Ichthyosis is the term used to describe continual and widespread scaling of the skin. There are several genetic types which are present from birth and persist life‐long – the "congenital ichthyoses". There is no agreed treatment ‐ different doctors use different approaches, so this group of experts from all over Europe worked together to develop guidelines. They reviewed the medical literature and met to discuss the evidence and to make recommendations. A separate paper (Part 1) covered treatments for the skin condition itself. This paper, Part 2, provides guidelines for managing complications of the congenital ichthyoses. Itch, pain and infections are common, particularly fungal infection, and cancers sometimes occur. Tight skin often prevents eyelids from shutting properly so the eye surface must be protected with lubricant; eyelid massage may help and retinoid medicine may soften tight skin but can dry the eyes further. Surgical options include injecting filler or grafting extra skin to the eyelid: if the patient's own ichthyotic skin is used the problem eventually recurs and mucous membrane from inside the mouth is a promising alternative. Hearing is commonly affected: blockage of ears by a build‐up of skin may be prevented by regular oil drops but syringing or suction may be necessary. In children, growth may be affected and vitamin D supplements are usually recommended. There are special considerations for newborn babies and those with complex ichthyotic disorders such as Netherton Syndrome, epidermolytic ichthyosis and Ichthyosis Prematurity Syndrome. These treatment guidelines should help to improve outcomes and quality of life for patients with congenital ichthyoses.
Abstract 207: In Vitro Modeling of Variable Heart Diseases Due to Lamin A/C Mutation via Patient induced Pluripotent Stem Cell Derived Cardiomyocytes
Authors: Mehrsa Mehrabi, Mira Asad, Danielle Becker, Halida Widyastuti, Cecilia Nguyen, Linda A Mccarthy, Michael V Zaragoza, Anna Grosberg
Journal: Circulation Research (2018)

According to numerous fundamental studies, a mutated Lamin A/C gene ( LMNA ) can cause dilated cardiomyopathy, arrhythmia, and heart failure, yet the practical diagnosis and treatment for them is scarce. The LMNA encodes Lamin A/C proteins that make mesh like nuclear lamina under the nuclear envelope, and they interact to impact the nuclear shape, stability, protein transduction, and DNA replication. Although, almost all nucleated cells in the human body have Lamin A/C in the nuclear lamina, we study patients who have LMNA mutation with the main pathologies in the heart. Therefore, our goal is to understand the mechanisms of how an LMNA mutation can cause exclusively heart diseases. We hypothesize that an in vitro model using induced Pluripotent Stem Cell (iPSC)-derived cardiomyocytes can differentiate between a population of patients whose major phenotype presentation is heart disease due to an LMNA mutation from the control population in structural and functional mechanisms. We have used in vitro tissue engineering techniques to interrogate the iPSC-derived cardiomyocytes tissue structures and function. PATIENT’s and CONTROL’s skin fibroblasts were reprogrammed to iPSCs and differentiated to cardiomyocytes. The PATIENT and CONTROL iPSC-derived cardiomyocytes were immunostained, imaged and quantified. Moreover, for the functional assay, iPSC- derived cardiomyocytes were evaluated by the “Heart-on-a-Chip” device based on the muscular thin film technology. The dynamics of the PATIENTs and CONTROLs tissue constructs were recorded and analyzed for frequency and stress as a function of time. Our results demonstrate that it is possible to construct an iPSC-derived cardiomyocyte in vitro model that differentiates between our CONTROL and PATIENT population and shows significant differences between iPSC-derived cardiomyocytes of PATIENTs and CONTROLs in frequency and active stress. By further investigating the structural and functional differences between PATIENTs and CONTROLs iPSC-derived cardiomyocytes, we can find the downstream mechanisms of LMNA mutation consequences in heart and find the proper treatments through drug screening and the other techniques by monitoring the function and structure of the iPSC-derived cardiomyocytes.
TRENDS IN INFECTIVE ENDOCARDITIS INCIDENCE, CHARACTERISTICS, AND VALVE REPLACEMENT IN PATIENTS WITH OPIOID USE DISORDERS IN THE UNITED STATES FROM 2005 TO 2014
Authors: Makoto Mori, Kelly Brown, Syed Usman Bin Mahmood, Arnar Geirsson, Abeel Mangi
Journal: Journal of the American College of Cardiology (2019)
LEFT ATRIAL FIBROSIS IS ASSOCIATED WITH LEFT ATRIAL DIASTOLIC DYSFUNCTION MEASURED BY PRESSURE/VOLUME CURVES IN PATIENTS UNDERGOING ABLATION FOR ATRIAL FIBRILLATION
Authors: Irfan M. Khurram, Farhan Maqbool, Saman Nazarian, Stefan Zimmerman, Vadim Zipunnikov, Hugh Calkins
Journal: Journal of the American College of Cardiology (2019)
INCREASED CLINICAL BURDEN OF HEART FAILURE IN PATIENTS WITH DEPRESSION: INSIGHTS FROM THE NATIONAL INPATIENT SAMPLE DATABASE
Authors: Abhishek Chaturvedi, Aditya Joshi, Parul Chandrika, Tarun Sharma, Mario Castagnaro, Craig Alpert, Indu Poornima, Amresh Raina
Journal: Journal of the American College of Cardiology (2019)
Stratum corneum and systemic biomarkers in infantile AD
Authors: M.A. McAleer, I. Jakasa, G. Hurault, P. Sarvari, W.H.I. McLean, R.J. Tanaka, S. Kezic, A.D. Irvine
Journal: British Journal of Dermatology (2019)

Atopic Dematitis (AD), also known as eczema, is a common inflammatory skin disease which usually appears during the early stages of life. It is estimated that approximately 15 million people in the UK are currently living with AD, affecting up to 20% of children. Indicators, such as a specific protein level in the body which is related to the presence or seriousness of a disease in a patient, may be important in ensuring proper treatment. Indicators of the seriousness of AD have been described for adults, however there is a need for similar indicators which could be used to define the seriousness of AD in infants, as this is usually when onset of the condition occurs. This study aimed to identify easily obtainable indicators from the skin of infants which could be used to predict AD. 100 children who had just developed moderate to severe AD which had not yet been treated and 20 children without AD were sampled as part of this study. The level of seriousness of AD in the affected children was graded at the start of the study and samples of the outer‐most layer of skin were taken from all participants. In total, 31 out of 66 indicators measured showed different levels in infants with AD than infants without AD. These indicators are known to be involved in various processes including the body's natural defence and the formation of new blood vessels. The authors of this study concluded that these results demonstrate easily obtainable indicators can be used to predict AD in infants, and that natural defence responses in the outer layer of skin are essential in preventing development of AD in infants.
INCREMENTAL PREDICTIVE VALUE OF CORONARY CALCIUM SCORE IN RISK STRATIFICATION USING MYOCARDIAL PERFUSION IMAGING WITH SEMICONDUCTOR SCANNER
Authors: Yasuyuki Suzuki, Sakura Nagumo, Keiichiro Kuronuma, Tadashi Ashida, Rei Matsuo, Ayano Makita, Shunichi Yoda, Naoya Matsumoto, Yasuo Okumura
Journal: Journal of the American College of Cardiology (2019)
THE IMPACT OF A CLOSED CARDIAC INTENSIVE CARE UNIT MODEL WITH A DEDICATED HEART FAILURE SPECIALIST ON THE PRIMARY OUTCOME OF DEATH IN CRITICALLY ILL PATIENTS
Authors: Yekaterina Kim, Aleksandr Kalininskiy, Mounica Yanamandala, Joshua Josephs, Navid Ahmed, Andrei Assa, Fathima Jahufar, Salil Kumar, Pauline Edwards, Aman Shah, Ulrich Jorde, Daniel Sims
Journal: Journal of the American College of Cardiology (2019)
Adrenaline can restart the heart, but is no good for the brain
Authors: Rob Cook, Peter Davidson, Rosie Martin
Journal: BMJ (2019)

The study A randomised trial of epinephrine in out-of-hospital cardiac arrest Perkins GD, Ji C, Deakin CD, Quinn T, Nolan JP, Scomparin C, Regan S, Long J, Slowther A, Pocock H, Black JJM, Moore F, Fothergill RT, Rees N, O’Shea L, Docherty M, Gunson I, Han K, Charlton K, Finn J, Petrou S, Stallard N, Gates S, Lall R for the PARAMEDIC2 Collaborators Published on 18 July 2018 N Engl J Med 2018;379:711-21. This project was funded by the National Institute for Health Research HTA Programme (project number 12/127/126). To read the full NIHR Signal, go to: https://discover.dc.nihr.ac.uk/content/signal-000639/adrenaline-can-restart-the-heart-but-is-no-good-for-the-brain