Influenza Vaccine: Routine Secondary Prevention for Patients With Cardiovascular Disease?
Authors: Chandini Raina MacIntyre
Journal: Annals of Internal Medicine (2020)

Editorials20 October 2020Influenza Vaccine: Routine Secondary Prevention for Patients With Cardiovascular Disease?Chandini Raina MacIntyre, MBBS Hons 1, PhDChandini Raina MacIntyre, MBBS Hons 1, PhDUniversity of New South Wales, Sydney, New South Wales, Australia (C.R.M.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/M20-5810 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The association between influenza and cardiovascular disease was first recognized with the observation that all-cause mortality increases with influenza epidemics, and evidence of more specific associations with myocardial infarction, stroke, and other cardiovascular outcomes has accrued since then (1). In their article, Chow and colleagues (2) confirm that cardiovascular events are an important contributor to the morbidity and mortality associated with influenza. They studied 80 261 adults with confirmed influenza and determined that almost 12% had an acute cardiovascular event, most commonly acute heart failure (6.2%) or acute ischemic heart disease (5.7%). This study also showed that patients with the combination ...References1. Warren-Gash C, Blackburn R, Whitaker H, et al. Laboratory-confirmed respiratory infections as triggers for acute myocardial infarction and stroke: a self-controlled case series analysis of national linked datasets from Scotland. Eur Respir J. 2018;51. [PMID: 29563170] doi:10.1183/13993003.01794-2017 CrossrefMedlineGoogle Scholar2. Chow EJ, Rolfes MA, O'Halloran A, et al. Acute cardiovascular events associated with influenza in hospitalized adults. A cross-sectional study. Ann Intern Med. 2020;173:605-13. doi:10.7326/M20-1509 LinkGoogle Scholar3. Muñoz P, Vicent L, Bouza E, et al. Prognostic implications of influenza virus infection in a cardiac intensive care unit: potential impact of a screening program. 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Cost-benefit analysis of a national influenza vaccination program in preventing hospitalisation costs in Australian adults aged 50-64 years old. Vaccine. 2019;37:5979-5985. [PMID: 31473001] doi:10.1016/j.vaccine.2019.08.028 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of New South Wales, Sydney, New South Wales, Australia (C.R.M.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M20-5810.Corresponding Author: Chandini R. MacIntyre, MBBS, PhD, The Kirby Institute, UNSW Medicine, Wallace Wurth Level 6, Sydney, NSW 2052, Australia; e-mail, r.[email protected]edu.au.This article was published at Annals.org on 25 August 2020. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAcute Cardiovascular Events Associated With Influenza in Hospitalized Adults Eric J. Chow , Melissa A. Rolfes , Alissa O'Halloran , Evan J. Anderson , Nancy M. Bennett , Laurie Billing , Shua Chai , Elizabeth Dufort , Rachel Herlihy , Sue Kim , Ruth Lynfield , Chelsea McMullen , Maya L. Monroe , William Schaffner , Melanie Spencer , H. Keipp Talbot , Ann Thomas , Kimberly Yousey-Hindes , Carrie Reed , and Shikha Garg Metrics 20 October 2020Volume 173, Issue 8Page: 660-661KeywordsCardiovascular diseasesElderlyFeversHeart failureMorbidityMortalityMyocardial infarctionPatientsThrombosisVaccines ePublished: 25 August 2020 Issue Published: 20 October 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...