tbuckley/cabot-search huggingface dataset:
Defining current gaps in quality measures for cancer immunotherapy: consensus report from the Society for Immunotherapy of Cancer (SITC) 2019 Quality Summit
Authors: Sara Pai, David Blaisdell, Rachel Brodie, Robert Carlson, Heidi Finnes, Michele Galioto, Roxanne E Jensen, Tom Valuck, Antonia R Sepulveda, Howard L Kaufman
Journal: Journal for ImmunoTherapy of Cancer (2020)

Background Quality measures are important because they can help improve and standardize the delivery of cancer care among healthcare providers and across tumor types. In an environment characterized by a rapidly shifting immunotherapeutic landscape and lack of associated long-term outcome data, defining quality measures for cancer immunotherapy is a high priority yet fraught with many challenges. Methods Thus, the Society for Immunotherapy of Cancer convened a multistakeholder expert panel to, first , identify the current gaps in measures of quality cancer care delivery as it relates to immunotherapy and to, second , advance priority concepts surrounding quality measures that could be developed and broadly adopted by the field. Results After reviewing the existing quality measure landscape employed for immunotherapeutic-based cancer care, the expert panel identified four relevant National Quality Strategy domains (patient safety, person and family-centered care, care coordination and communication, appropriate treatment selection) with significant gaps in immunotherapy-based quality cancer care delivery. Furthermore, these domains offer opportunities for the development of quality measures as they relate to cancer immunotherapy. These four quality measure concepts are presented in this consensus statement. Conclusions This work represents a first step toward defining and standardizing quality delivery of cancer immunotherapy in order to realize its optimal application and benefit for patients.
Price transparency is a step towards sustainable access in middle income countries
Authors: Tania Cernuschi, Shawn Gilchrist, Adnan Hajizada, Melissa Malhame, Stephanie Mariat, Greg Widmyer
Journal: BMJ (2020)

<b>Tania Cernuschi and colleagues</b> show how information from the Market Information for Access to Vaccines database is strengthening the ability of middle income countries to negotiate with vaccine producers
Differences in Kras and Braf Mutation Prevalence in Metastatic Colorectal Carcinoma Using High-Sensitivity Taqmelt vs Arms-Scorpion Pcr Assays
Authors: S. Zazo, T. Caldes, N. Pérez González, J. Madoz, J. Satre, R. Manso, D. Ferrandez, T. Ramos, J. Garcia-Foncillas, E. Diaz-Rubio
Journal: Annals of Oncology (2012)
Benefit-to-risk balance of bronchoalveolar lavage in the critically ill. A prospective, multicenter cohort study
Authors: Toufik Kamel, Julie Helms, Ralf Janssen-Langenstein, Achille Kouatchet, Antoine Guillon, Jeremy Bourenne, Damien Contou, Christophe Guervilly, Rémi Coudroy, Marie Anne Hoppe, Jean Baptiste Lascarrou, Jean Pierre Quenot, Gwenhaël Colin, Paris Meng, Jérôme Roustan, Christophe Cracco, Mai-Anh Nay, Thierry Boulain
Journal: Intensive Care Medicine (2020)
Comparison of Mobilized Peripheral Blood Stem Cells Versus Unmanipulated Bone Marrow Haploidentical Transplantation Using Post-Transplant Cyclophosphamide: A Retrospective Study of SFGM-TC in 176 Patients
Authors: Nathalie Jacque, Jérôme Lambert, Ibrahim Yakoub-Agha, Reza Tabrizi, Mauricette Michallet, Eric Deconinck, Sylvain Thepot, Mathieu Meunier, Regis Peffault De Latour, Felipe Suarez, Amandine Charbonnier, Pascal Turlure, Patrice Ceballos, Gaelle Guillerm, Gerard Michel, Nathalie Contentin, Tony Marchand, Lionel Mannone, Jean-Hugues Dalle, Jean Valère Malfuson, Bruno Lioure, Marie Thérèse Rubio, Stephanie Nguyen
Journal: Blood (2017)
Cardiac Safety of (NEO) Adjuvant Trastuzumab in the Brazilian Community Setting: A Single Center Experience
Authors: L.G. Fonseca, T.K. Takahashi, M.P. Mak, R. Barroso-Sousa, L. Testa, V. Petry Helena, R.Paula De Costa, P.M. Hoff, M.S. Mano
Journal: Annals of Oncology (2012)
P-0206 Early-Onset Colorectal Cancer: The Comparative Molecular Classification Suggests The Existence of Two new Different Groups Within Colorectal Cancer
Authors: Edurne Álvaro, José Perea, Daniel Rueda, Cristina Alegre, Alicia Canal, Yolanda Rodriguez, Irene Osorio, Miguel Urioste
Journal: Annals of Oncology (2012)
P1.07 New Genetic Variants ARE Associated with Breast Cancer Susceptibility &amp; Aggressiveness in the Tunisian Population
Authors: L. Chouchane, J. Shan, D. Kizhakayil, I. Aigha, S. Dsouza, B. Noureddine, S. Gabbouj, R. Mathew, E. Hassen
Journal: Annals of Oncology (2012)
Association of Early Palliative Care With Survival in Patients With Advanced Lung Cancer—Reply
Authors: Donald R. Sullivan, Christopher G. Slatore
Journal: JAMA Oncology (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Combinations of Laminin 5 with PTEN, p-EGFR, and p-AKT Define a Group with Poorer Prognosis in Patients with NSCLC
Authors: S.-J. An, Q.-X. Lin, Z.-H. Chen, J. Su, H. Cheng, Z. Xie, X.-C. Zhang, H.-Y. Zhou, Y. Huang, S.-L. Chen, W.-B. Guo, Y.-L. Wu
Journal: Annals of Oncology (2012)
Individualizing the starting dose for MPT therapy in elderly myeloma patients.
Authors: Gary E Blau, Seza Orcun, Jose Miguel Lainez, Gintaras V Reklaitis, Attaya Suvannasankha, Christopher A. Fausel, Patrick Kiel, Elias J. Anaissie
Journal: Journal of Clinical Oncology (2012)

e18555 Background: Many elderly or frail myeloma patients ineligible for autologous stem cell transplant (ASCT) receive non-myeloablative therapies such as the melphalan/prednisone/thalidomide (MPT) combination. These agents have variable pharmacokinetics (PK), and hence variable anti-tumor responses and toxicities. Yet, their dosing is uniform, partly because no convenient procedure exists to individualize dosage-schedules (costs and logistical difficulties with multiple blood samplings for a given patient). We herein propose a novel PK methodology that allows for individualized dosing of these agents. Methods: The MPT regimen is commonly used for older patients and consists of six cycles of 4mg/m 2 M, 40mg/m 2 P and 100mg T administered for seven days followed by a three-week rest period. To compare the peripheral blood concentrations between individuals, a marker combining the level and duration of exposure is the time weighted “average concentration” defined by CC=(Cumulative Area under the concentration time curve (AUC))/(Elapsed time from start of treatment). Using pattern recognition software, an individual’s PK profile was simulated from the population PK models using a single blood draw 2h after administration. The AUC for the individual is then used to adjust the starting dose to match the CC target profile based on the average population response. Results: Using PK data for the individual patients used to construct the PK population model, the simulated adjusted doses for initializing the therapy vary as follows: M 2.5-6mg/m 2 ; P 12.5-140mg/m 2 ; and T 76-130mg which is substantially different from the "standard" uniform dosing. Conclusions: The wide variability in dose levels obtained with the pattern recognition software may explain the marked differences in response and toxicities to the “standard” dosing protocol. An individualized starting dose can be applied using the proposed methodology which requires only a single blood draw after a lower “test dose” of these agents “prior” to commencing actual therapy.
Patient Registries in Idiopathic Pulmonary Fibrosis: Don't Forget Socioeconomic Status
Authors: Lucile Sesé, Catherine Cavalin, Jean-François Bernaudin, Isabella Annesi Maesano, Hilario Nunes
Journal: American Journal of Respiratory and Critical Care Medicine (2020)

the most common brand (3, 4).CDC laboratory test results of BAL fluid samples from 29 patients submitted to the CDC from 10 states found vitamin E acetate in all the samples (1).Vitamin E acetate is an oil used to thicken e-cigarette liquid.Although all the CDC BAL analyses were of THC-containing vape liquids, a recent report from South Korea showed vitamin E acetate present in nicotinecontaining products, including JUUL pods (5).Eissenberg and Maziak suggest that lipid materials in e-cigarette liquids, particularly vegetable glycerin, are the likely cause of EVALI in patients who only used nicotine-containing products.Whether the lipid is vitamin E acetate or vegetable glycerin or another agent, inhaling lipid-containing aerosol generated by high heat can lead to the generation of lipid-laden macrophages, recently reported by Maddock and colleagues in cases of EVALI from Utah (6).Electronic nicotine delivery systems can play a beneficial role in tobacco smoking cessation, but only if the e-cigarette liquid is properly and safely prepared.I fully agree with Eissenberg and Maziak's call for strict regulation of e-cigarette liquid contents.
Visual Effects in Anaplastic Lymphoma Kinase (ALK)-Positive Advanced Non-Small-Cell Lung Cancer (NSCLC) Patients Treated with Crizotinib
Authors: P.-C. Yang, R. Salgia, B. Solomon, A.T. Shaw, D.R. Camidge, T.L. Evans, D.-W. Kim, Y. Shi, J.-Y. Han, T.M. De Pas, S.-H.I. Ou, C.H. Bartlett, K. Wilner, A. Reisman, S. Iyer
Journal: Annals of Oncology (2012)
Clinical Features in Renal Cell Cancer Patients in TKI ERA: An Analysis of Web-Based Registry Data, Korea Cancer Study Group, GU &amp; GY Committee, KCSG GU10-12
Authors: H.Y. Kim, H.J. Lee, H.S. Kim, K.A. Kwon, N.-R. Lee, J.-M. Sun, K.H. Park, S.J. Koh, S.H. Hong, W.K. Bae, S.-H. Lee, J.-L. Lee, H.Y. Lim, S.Y. Rha
Journal: Annals of Oncology (2012)
Opportunities and Challenges in Valuing and Evaluating Aging Physicians
Authors: Katrina A. Armstrong, Eileen E. Reynolds
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
P-0014 A Phase II Study With Oxaliplatin, Leucovorin and Tegafur-Uracil as First-Line Treatment for Metastatic or Locally Advanced, Unresectable Esophageal Cancer
Authors: Nicoline Raaschou-Jensen, Kell Oesterlind, Mette Yilmaz, Jens Bentzen, Lars Damstrup, Lene Baeksgaard
Journal: Annals of Oncology (2012)
Shared Genetic Loci Between Body Mass Index and Major Psychiatric Disorders
Authors: Shahram Bahrami, Nils Eiel Steen, Alexey Shadrin, Kevin O’Connell, Oleksandr Frei, Francesco Bettella, Katrine V. Wirgenes, Florian Krull, Chun C. Fan, Anders M Dale, Olav B. Smeland, Srdjan Djurovic, Ole A. Andreassen
Journal: JAMA Psychiatry (2020)

<h3>Importance</h3> People with major psychiatric disorders (MPDs) have a 10- to 20-year shorter life span than the rest of the population, and this difference is mainly due to comorbid cardiovascular diseases. Genome-wide association studies have identified common variants involved in schizophrenia (SCZ), bipolar disorder (BIP), and major depression (MD) and body mass index (BMI), a key cardiometabolic risk factor. However, genetic variants jointly influencing MPD and BMI remain largely unknown. <h3>Objective</h3> To assess the extent of the overlap between the genetic architectures of MPDs and BMI and identify genetic loci shared between them. <h3>Design, Setting, and Participants</h3> Using a conditional false discovery rate statistical framework, independent genome-wide association study data on individuals with SCZ (n = 82 315), BIP (n = 51 710), MD (n = 480 359), and BMI (n = 795 640) were analyzed. The UK Biobank cohort (n = 29 740) was excluded from the MD data set to avoid sample overlap. Data were collected from August 2017 to May 2018, and analysis began July 2018. <h3>Main Outcomes and Measures</h3> The primary outcomes were a list of genetic loci shared between BMI and MPDs and their functional pathways. <h3>Results</h3> Genome-wide association study data from 1 380 284 participants were analyzed, and the genetic correlation between BMI and MPDs varied (SCZ:<i>r </i>for genetic = −0.11,<i>P</i> = 2.1 × 10<sup>−10</sup>; BIP:<i>r </i>for genetic = −0.06,<i>P</i> = .0103; MD:<i>r </i>for genetic = 0.12,<i>P</i> = 6.7 × 10<sup>−10</sup>). Overall, 63, 17, and 32 loci shared between BMI and SCZ, BIP, and MD, respectively, were analyzed at conjunctional false discovery rate less than 0.01. Of the shared loci, 34% (73 of 213) in SCZ, 52% (36 of 69) in BIP, and 57% (56 of 99) in MD had risk alleles associated with higher BMI (conjunctional false discovery rate &lt;0.05), while the rest had opposite directions of associations. Functional analyses indicated that the overlapping loci are involved in several pathways including neurodevelopment, neurotransmitter signaling, and intracellular processes, and the loci with concordant and opposite association directions pointed mostly to different pathways. <h3>Conclusions and Relevance</h3> In this genome-wide association study, extensive polygenic overlap between BMI and SCZ, BIP, and MD were found, and 111 shared genetic loci were identified, implicating novel functional mechanisms. There was mixture of association directions in SCZ and BMI, albeit with a preponderance of discordant ones.
Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
Authors: Julia Marschallinger, Tal Iram, Macy Zardeneta, Song E. Lee, Benoit Lehallier, Michael S. Haney, John V. Pluvinage, Vidhu Mathur, Oliver Hahn, David W. Morgens, Justin Kim, Julia Tevini, Thomas K. Felder, Heimo Wolinski, Carolyn R. Bertozzi, Michael C. Bassik, Ludwig Aigner, Tony Wyss-Coray
Journal: Nature Neuroscience (2020)
Malnutrition at Diagnosis Independently Predicts Mortality in Patients with Systemic Immunoglobulin Light-Chain Amyloidosis (AL)
Authors: R. Caccialanza, G. Palladini, C. Klersy, E. Cereda, C. Bonardi, L. Quarleri, G. Merlini
Journal: Annals of Oncology (2012)
Nucleoside-modified mRNA vaccination partially overcomes maternal antibody inhibition of de novo immune responses in mice
Authors: Elinor Willis, Norbert Pardi, Kaela Parkhouse, Barbara L. Mui, Ying K. Tam, Drew Weissman, Scott E. Hensley
Journal: Science Translational Medicine (2020)

Unlike conventional influenza vaccines, mRNA vaccination partially overcomes maternal antibody inhibition of de novo immune responses in infant mice.
Undifferentiated Pleomorphic Sarcoma (UPS): An Analysis of 135 Patients (PTS) with this Clinically Unique Subtype of High-Grade Soft Tissue Sarcoma (HG-STS)
Authors: M.F. Harunal Rashid, S. Pan, T. Mann Hong, L. Foo Siang Sheng, K. Sittampalam, A. Sairi, K. Adam, F. Chin, M. Teo, R. Quek
Journal: Annals of Oncology (2012)
Role of Mitochondrial Calcium and the Permeability Transition Pore in Regulating Cell Death
Authors: Tyler M. Bauer, Elizabeth Murphy
Journal: Circulation Research (2020)

Adult cardiomyocytes are postmitotic cells that undergo very limited cell division. Thus, cardiomyocyte death as occurs during myocardial infarction has very detrimental consequences for the heart. Mitochondria have emerged as an important regulator of cardiovascular health and disease. Mitochondria are well established as bioenergetic hubs for generating ATP but have also been shown to regulate cell death pathways. Indeed many of the same signals used to regulate metabolism and ATP production, such as calcium and reactive oxygen species, are also key regulators of mitochondrial cell death pathways. It is widely hypothesized that an increase in calcium and reactive oxygen species activate a large conductance channel in the inner mitochondrial membrane known as the PTP (permeability transition pore) and that opening of this pore leads to necroptosis, a regulated form of necrotic cell death. Strategies to reduce PTP opening either by inhibition of PTP or inhibiting the rise in mitochondrial calcium or reactive oxygen species that activate PTP have been proposed. A major limitation of inhibiting the PTP is the lack of knowledge about the identity of the protein(s) that form the PTP and how they are activated by calcium and reactive oxygen species. This review will critically evaluate the candidates for the pore-forming unit of the PTP and discuss recent data suggesting that assumption that the PTP is formed by a single molecular identity may need to be reconsidered.
VEGF and VEGF Receptors in Thymic Epithelial Tumors (Tet): Pathological Features and Clinical Implications
Authors: L. Nappi, V. Damiano, M. Marino, T. Gelardi, L. Formisano, P. Federico, E. Matano, L. Puglia, S. De Placido, G. Palmieri
Journal: Annals of Oncology (2012)
Additional Safety Results of Hannah: A Phase III Randomised, Open-Label, International Study of the Subcutaneous Formulation of Trastuzumab (H) in HER2-Positive Early Breast Cancer Patients
Authors: C. Jackisch, M. Dank, G. Frasci, K.H. Park, R.I. Lopez, M. Johnston, D. Heinzmann, H. Weber, G. Ismael
Journal: Annals of Oncology (2012)
Prevalence of Brugada Syndrome in a Large Population of Young Singaporean Men
Authors: Xiayan Shen, Benjamin Y.Q. Tan, Ching-Hui Sia, Joshua S.W. Lee, Mayank Dalakoti, Kangjie Wang, Daniel Y.Z. Lim, Gerald G.R. Sng, Edward C.Y. Lee, Weien Chow, Clarence K.W. Kwan, Luo Kai Wang, Boon Yew Tan, Paul Chun Yih Lim, Kelvin C.M. Chua, Kah Leng Ho, Eric T.S. Lim, Chi Keong Ching, Wee Siong Teo, Terrance S.J. Chua, Ru San Tan, Tee Joo Yeo, Daniel T.T. Chong
Journal: Circulation (2020)
Is Change to Another Treatment Immediately After Failure of Gefitinib Recommended in Patients Harboring Activating Epidermal Growth Factor Receptor Mutations
Authors: K. Asami, T. Okuma, T. Hirashima, M. Kawahara, T. Kawaguchi, K. Okishio, N. Omachi, N. Takeuchi
Journal: Annals of Oncology (2012)
P1.30 Intratumoral Heterogeneity in Expression of Chemotherapy Response Markers in Invasive Ductal Breast Carcinoma Nos
Authors: E. Denisov, M. Tsyganov, L. Tashireva, M. Zavyalova, V. Perelmuter, N. Cherdyntseva
Journal: Annals of Oncology (2012)
Characteristics of Persons Who Report Using Only Nicotine-Containing Products Among Interviewed Patients with E-cigarette, or Vaping, Product Use–Associated Lung Injury — Illinois, August–December 2019
Authors: Isaac Ghinai, Livia Navon, Jayleen K.L. Gunn, Lindsey M. Duca, Sarah Brister, Sarah Love, Rachel Brink, Geroncio Fajardo, Jona Johnson, Lori Saathoff-Huber, Brian A. King, Christopher M. Jones, Vikram P. Krishnasamy, Jennifer E. Layden
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

Vitamin E acetate, which has been detected in tetrahydrocannabinol -containing e-cigarette, or vaping, products, is strongly linked to the e-cigarette, or vaping, product use–associated lung injury outbreak; however, evidence is not sufficient to rule out the contribution of other chemicals of concern, including chemicals in either THC- or non-THC-containing products, in some reported EVALI cases.
Dna-Repair Gene Polymorphisms Associated with Favorable Clinical Outcome Following Cetuximab-Based Therapy for Elderly and Multi-Morbid Patients with Primary and Recurrent Squamous Cell Carcinoma of the Head and Neck
Authors: Y. Chang, N. Su, Y. Leu, J. Lee, C. Liu, Y. Chen, H. Chen, I. Fang, A. Lo, R. Hsieh
Journal: Annals of Oncology (2012)
Association of CYP1A1 A4889G and T6235C Polymorphisms With Increased Risk and Aggressiveness of Breast Cancer
Authors: C.B.M. Oliveira, C. Cardoso-Filho, M.S. Costa-Gurgel, L.S. Bossi, C.S.P. Lima, G.J. Lourenço
Journal: Annals of Oncology (2012)
Docetaxel Monotherapy Compared with Carboplatin and Paclitaxel Doublet Chemotherapy in Elderly Patients with Non-Small-Cell Lung Cancer
Authors: S. Hirano, Y. Takeda, G. Naka, M. Iikura, H. Udagawa, S. Izumi, H. Sugiyama, N. Kobayashi
Journal: Annals of Oncology (2012)
Treatment of a Mouse Model of ALS by In Vivo Base Editing
Authors: Colin K.W. Lim, Michael Gapinske, Alexandra K. Brooks, Wendy S. Woods, Jackson E. Powell, M. Alejandra Zeballos C., Jackson Winter, Pablo Perez-Pinera, Thomas Gaj
Journal: Molecular Therapy (2020)

Amyotrophic lateral sclerosis (ALS) is a debilitating and fatal disorder that can be caused by mutations in the superoxide dismutase 1 (SOD1) gene. Although ALS is currently incurable, CRISPR base editors hold the potential to treat the disease through their ability to create nonsense mutations that can permanently disable the expression of the mutant SOD1 gene. However, the restrictive carrying capacity of adeno-associated virus (AAV) vectors has limited their therapeutic application. In this study, we establish an intein-mediated trans-splicing system that enables in vivo delivery of cytidine base editors (CBEs) consisting of the widely used Cas9 protein from Streptococcus pyogenes. We show that intrathecal injection of dual AAV particles encoding a split-intein CBE engineered to trans-splice and introduce a nonsense-coding substitution into a mutant SOD1 gene prolonged survival and markedly slowed the progression of disease in the G93A-SOD1 mouse model of ALS. Adult animals treated by this split-intein CRISPR base editor had a reduced rate of muscle atrophy, decreased muscle denervation, improved neuromuscular function, and up to 40% fewer SOD1 immunoreactive inclusions at end-stage mice compared to control mice. This work expands the capabilities of single-base editors and demonstrates their potential for gene therapy.