The Uncertain Clinical Benefit of the T2Bacteria Panel
Authors: David A. Weinrib, Gerald A. Capraro
Journal: Annals of Internal Medicine (2019)

Editorials18 June 2019The Uncertain Clinical Benefit of the T2Bacteria PanelDavid A. Weinrib, MD and Gerald A. Capraro, PhD, D(ABMM)David A. Weinrib, MDAtrium Health - Carolinas Medical Center, Charlotte, North Carolina (D.A.W.) and Gerald A. Capraro, PhD, D(ABMM)Atrium Health Clinical Microbiology Laboratory, Charlotte, North Carolina (G.A.C.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/M19-0971 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Culture-independent diagnostic tests (CIDTs) have important and well-established clinical roles in the diagnosis of conditions for which classic cultures are insensitive, such as Neisseria gonorrhoeae infection and Clostridioides difficile infection (1). For the former, CIDTs replaced gonorrhea culture, which has low sensitivity related to the challenges of working with a fastidious organism. For the latter, culture has long since been replaced by antigen and toxin testing, and polymerase chain reaction (PCR) for toxin DNA is used to arbitrate discordant results or, at some institutions, has replaced antigen and toxin testing altogether. In the context of optimizing antimicrobial use, several new ...References1. Capraro GA. Replacement of culture with molecular testing for diagnosis of infectious diseases. Advances in Molecular Pathology. 2018;1:91-6. doi:10.1016/j.yamp.2018.07.002 CrossrefGoogle Scholar2. Bauer KA, Perez KK, Forrest GN, Goff DA. Review of rapid diagnostic tests used by antimicrobial stewardship programs. Clin Infect Dis. 2014;59 Suppl 3:S134-45. [PMID: 25261540] doi:10.1093/cid/ciu547 CrossrefMedlineGoogle Scholar3. Nguyen MH, Clancy CJ, Pasculle AW, Pappas PG, Alangaden G, Pankey GA, et al. Performance of the T2Bacteria Panel for diagnosing bloodstream infections. A diagnostic accuracy study. Ann Intern Med. 2019;170:845-52. doi:10.7326/M18-2772 LinkGoogle Scholar4. U.S. Food and Drug Administration. 510(k) Substantial Equivalence Determination. Decision Summary: Assay Only Template. Silver Spring, MD: U.S. Food and Drug Administration. Accessed at www.accessdata.fda.gov/cdrh_docs/reviews/K172708.pdf on 24 March 2019. Google Scholar5. Banerjee R, Teng CB, Cunningham SA, Ihde SM, Steckelberg JM, Moriarty JP, et al. Randomized trial of rapid multiplex polymerase chain reaction-based blood culture identification and susceptibility testing. Clin Infect Dis. 2015;61:1071-80. [PMID: 26197846] doi:10.1093/cid/civ447 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Atrium Health - Carolinas Medical Center, Charlotte, North Carolina (D.A.W.)Atrium Health Clinical Microbiology Laboratory, Charlotte, North Carolina (G.A.C.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M19-0971.Corresponding Author: David A. Weinrib, MD, Internal Medicine Department, Carolinas Medical Center, Medical Education Building, 1000 Blythe Boulevard, Charlotte, NC 28210; e-mail, david.[email protected]org.Current Author Addresses: Dr. Weinrib: Internal Medicine Department, Carolinas Medical Center, Medical Education Building, 1000 Blythe Boulevard, Charlotte, NC 28210.Dr. Capraro: Atrium Health Clinical Microbiology Laboratory, 5040 Airport Center Parkway, Building H, Suite A, Charlotte, NC 28208.This article was published at Annals.org on 14 May 2019. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPerformance of the T2Bacteria Panel for Diagnosing Bloodstream Infections M. Hong Nguyen , Cornelius J. Clancy , A. William Pasculle , Peter G. Pappas , George Alangaden , George A. Pankey , Bryan H. Schmitt , Altaf Rasool , Melvin P. Weinstein , Raymond Widen , Diana R. Hernandez , Donna M. Wolk , Thomas J. Walsh , John R. Perfect , Mollie N. Wilson , and Eleftherios Mylonakis Annals On Call - Bacterial Panels: Pros and Cons Robert M. Centor and Todd McCarty Metrics Cited byRole of the T2Dx magnetic resonance assay in patients with suspected bloodstream infection: a single-centre real-world experienceCulture-independent detection systems for bloodstream infectionNew Microbiological Techniques for the Diagnosis of Bacterial Infections and Sepsis in ICU Including Point of CareDevelopment and implementation of a customised rapid syndromic diagnostic test for severe pneumoniaDevelopment and implementation of a customised rapid syndromic diagnostic test for severe pneumoniaDevelopment and implementation of a customised rapid syndromic diagnostic test for severe pneumoniaA multiplex polymerase chain reaction assay for antibiotic stewardship in suspected pneumoniaIn-depth analysis of T2Bacteria positive results in patients with concurrent negative blood culture: a case seriesDiagnosis of bacterial sepsis: why are tests for bacteremia not sufficient? 18 June 2019Volume 170, Issue 12Page: 888-889KeywordsAntibioticsBacteremiaBloodGonorrheaResearch laboratoriesSepsisStaphylococcal infectionStaphylococcus aureusToxinsUrine ePublished: 14 May 2019 Issue Published: 18 June 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. 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