tbuckley/cabot-search huggingface dataset:
AB1371-HPR EFFECTS OF MORNING STIFFNESS ON THE PSYCHOSOCIAL AND FUNCTIONAL STATUS OF PATIENTS WITH JUVENILE IDIOPATHIC ARTHRITIS
Authors: Fatma Birgül Kumbaroğlu, Aykut Özçadırcı, Selcan Demir, Yelda Bilginer, Edibe Ünal, Seza Özen
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> Juvenile Idiopathic Arthritis (JIA) is a chronic childhood autoimmune disease that has significant implications on a childs physical health and psychosocial integration (1). Common symptoms of JIA include pain, joint stiffness, joint swelling, fatigue, and decreased physical function (2,3). <h3>Objectives</h3> The aim of this study is to investigate the effects of morning stiffness on the psychosocial and functional status of patients with JIA. <h3>Methods</h3> 387 JIA patients were included in this study. To determine the functional status of the patients functional subscale of The Juvenile Arthritis Biopsychosocial-Questionnaire (JAB-Q) and Childhood Health Assessment Questionnaire (CHAQ) were used. Psychosocial subscale of JAB-Q was used to assess psychosocial status. Finally, morning stiffness was measured as "less than 30 minutes", "between 30 minutes and 1 hour" and "more than 1 hour". <h3>Results</h3> A total of 162 boys and 225 girls participated in the study (Table 1). The effect of morning stiffness on functional and psychosocial status was examined with Kruskal Wallis analysis. There were statistically significant differences between the functional status (CHAQ Total, p=0,001; CHAQ General VAS, p=0.012; CHAQ Pain VAS, 0.001; Function JAB-Q, p&lt;0.001) of the patients and the duration of morning stiffness. However, there was no significant difference between the duration of morning stiffness and psychosocial status. Mann-Whitney U test was performed to test the significance of a pairwise difference using Bonferroni correction to adjust for multiple comparisons revealed that the difference between the groups was due to the morning stiffness duration "less than 30 minutes" group (Table 2). 1= &lt;30 min morning stiffness, 2= 30 min-1 hour morning stiffness, 3= &gt;1 hour morning stiffness <h3>Conclusion</h3> In our study, as a result psychosocial status was not affected by duration of morning stiffness. On the other hand, functionality of patients were getting worse as the duration of morning stiffness increases. It was concluded that psychosocial status should be dealt with independently of functional status, and children should be supported to participate in psychosocial environment such as school attendance, social activities. <h3>References</h3> [1] Cassidy JT, Petty RE. Chronic arthritis in childhood. In Textbook of pediatric rheumatology. 5th edition.Edited byCassidy JT, Petty RE, Laxer RM, Lindsley CB. Philadelphia, PA: Elsevier Saunders; 2005; 206-60 [2] Stanley LC, Ward-Smith P. The diagnosis and management of juvenile idiopathic arthritis. J Pediatr Health Care 2011;25:191-94. [3] Johnson CJ, Reilly KM, Murray KM. Etanercept in juvenile rheumatoid arthritis. Annals of Pharmacotherapy 2001;35:464-71. <h3>Disclosure of Interests</h3> None declared
THU0087 UTILITY OF INFRARED THERMOGRAPHY FOR THE EVALUATION OF RHEUMATOID ARTHRITIS
Authors: Jesús Loarce-Martos, Javier Bachiller-Corral, Ismael Fernández Cuevas, Manuel Sillero Quintana, Mónica Vázquez Díaz
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background:</h3> Rheumatoid Arthritis (RA) is a chronic inflammatory disease, which predominantly affects the hands. Currently in clinical practice, we explore the number of swollen and painful joints in order to evaluate the activity of the disease. Infrared thermography (IT) is a non-invasive, lacking ionizing radiation, operator-independent and low-cost technique that allows to measure the temperature of the cutaneous surface through the taking of a photograph. <h3>Objectives:</h3> To determine the utility of IT in the evaluation of hands arthritis in patients with RA. <h3>Methods:</h3> A cross-sectional study was performed, including patients with RA according to 2010 ACR/EULAR criteria attended in our Hospital between February and March 2018. Demographic, clinical and analytical characteristics of patients were registered. Number of painful and swollen joints were assessed for each patient, including wrist, metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints. Subsequently, a standardised photograph of the dorsal aspect of both hands was taken with a thermal camera (FLIR T250 model) (Figure 1). With this technique mean temperature (MeanT) and maximum temperature (MaxT) were assessed at each joint. Also, differential temperature (DifT) was assessed (mean temperature at joint - temperature at forearm skin). <h3>Results:</h3> We included a total of 42 patients. 76% were women, mean age at diagnosis was 56.7 years old. 29 patients were positive for rheumatoid factor and 31 for anti-citrullinated peptide antibody. At the time of the assessment, medium CRP was 9.19 mg/L and ESR was 14.77 mm/h. MeanT for the 65 swollen joints was 1.5°C higher than the 847 non-swollen joints (p=0.000). Independent analysis for each joint level (wrist, MCP and PIP) revealed higher temperature in swollen joints (Table 1). Similar results were obtained for painful joints. ROC curves and areas under the curve (AUC) were calculated for wrist, MCP and PIP joints, obtaining the most favorable results for DifT in wrist and MCP joints, and for MaxT in PIP joints, allowing to calculate a cut-off point at each joint level (Table2). <h3>Conclusion:</h3> In patients with RA, there is a statistically significant relationship between joint temperature measured by thermal imaging and the presence of swollen and painful joints in the assessment by the rheumatologist. The ROC curves indicate an acceptable sensitivity and specificity and allow to determine cut-off temperatures for clinical use. Infrared thermography could be a useful tool in the assessment and monitoring of arthritis in RA patients. <h3>Reference:</h3> [1] Jones B, Hassan I, Tsuyuki RT, Dos Santos MF, Russell AS, Yacyshyn E. Hot joints: myth or reality? A thermographic joint assessment of inflammatory arthritis patients. Clin Rheumatol. 2018 Sep 20;37(9):2567–71 <h3>Disclosure of Interests:</h3> None declared
PB2176 DIAGNOSIS AND MANAGEMENT OF SYSTEMIC AL AMYLOIDOSIS IN REAL WORLD
Authors: M. Sirvent, L. Ondarra, N. Segues, C. Sarasqueta, A. Alkorta, M. Hernandez, N. Caminos, E. Perez, P. Romero, I. Zeberio, A. Aranbarri, I. Otero, C. Lombardi, J. Iriondo, A. Altuna, M. Araiz
Journal: HemaSphere (2019)

Background: Light‐chain (AL) amyloidosis is the most common form of systemic amyloidosis, accounting for 70% of patients with amyloidosis. It is characterized by deposition of a misfolded monoclonal light‐chain that is secreted from a malignant plasma cell clone, and interferes with an organ's normal function. Clinical features depends on organs involved. To continue improving patient prospects, early and accurate diagnosis and meticulous treatment choices are essential. Immunohistochemistry of abdominal fat aspirates is the most widely available method for amyloid typing, and it has to be done by a highly specialized pathologist, combined with clinical data and genotyping, it may lead to accurate amyloidosis classification. Delayed diagnosis remains a major obstacle to initiating effective therapy. Aims: To describe retrospectively the diagnosis and management in our hospital, of twenty five patients with biopsy‐proven systemic AL amyloidosis (included between 05/2011‐01/2019). Methods Median age at diagnosis was 64 years (range 45‐84). 44% patients were male and 56% female. At baseline evaluation, λ free light chains was shown in 92%, median bone marrow plasma cells was 10.9% (5 patients had associated MM), 12% had unfavorable genetic. Mayo stage was distributed as follows: I (8%), II (20%), III (28%), IV (44%). 20 pts (80%) had cardiac involved and 12 (60%) had typical pattern of delayed gadolinium enhancement in magnetic resonance. Median left ventricle thickness was 16.7 mm. Results: The histological diagnosis was in 28% by renal biopsy, 20% minor salivary gland, 16% fat aspiration, 8% cardiac, and proceeds with mass spectroscopy in 2 patients. Fat aspiration was performed in 15 pts (60%), but only 4 (26%) were positive. 44% received one regimen of treatment [0‐6 lines]. Bortezomib and lenalidomide were the most used drugs in first and second line (80% and 32% respectively). 20% underwent ASCT (only 2 directly). 16% received doxycycline. The hematologic and organic response for each line and PFS is shown in table 1. Median PFS was decreasing with Mayo stage (1‐2 stage: 16 month, 3: 9.7 months, 4: 7 months. Median OS was 4 years [95% CI 1.5‐6.4] with median follow up of 7.8 years, and median OS in patients achieving RC/VGPR was 4.9 years [95% CI 1.7‐8]. Summary/Conclusion: 1) Our series PFS and OS are worse comparing with literature, in real world AL amyloidosis is still diagnosed late, in advance Mayo stage (72%), and cardiac involvement. 2) The fat aspiration is not the diagnosis tool in the most cases. 3) Early diagnosis is the key to managing the disease and improves de survival of these patients. 4) It could be recommendable to start therapy, if clinical‐analytic suspicious is high, although without histological confirmation, but it has to be provided in further studies. image
Interdependence, Reflexivity, Fidelity, Impedance Matching, and the Evolution of Genetic Coding
Authors: Charles W Carter, Peter R Wills
Journal: Molecular Biology and Evolution (2017)

Genetic coding is generally thought to have required ribozymes whose functions were taken over by polypeptide aminoacyl-tRNA synthetases (aaRS). Two discoveries about aaRS and their interactions with tRNA substrates now furnish a unifying rationale for the opposite conclusion: that the key processes of the Central Dogma of molecular biology emerged simultaneously and naturally from simple origins in a peptide•RNA partnership, eliminating the epistemological utility of a prior RNA world. First, the two aaRS classes likely arose from opposite strands of the same ancestral gene, implying a simple genetic alphabet. The resulting inversion symmetries in aaRS structural biology would have stabilized the initial and subsequent differentiation of coding specificities, rapidly promoting diversity in the proteome. Second, amino acid physical chemistry maps onto tRNA identity elements, establishing reflexive, nanoenvironmental sensing in protein aaRS. Bootstrapping of increasingly detailed coding is thus intrinsic to polypeptide aaRS, but impossible in an RNA world. These notions underline the following concepts that contradict gradual replacement of ribozymal aaRS by polypeptide aaRS: 1) aaRS enzymes must be interdependent; 2) reflexivity intrinsic to polypeptide aaRS production dynamics promotes bootstrapping; 3) takeover of RNA-catalyzed aminoacylation by enzymes will necessarily degrade specificity; and 4) the Central Dogma's emergence is most probable when replication and translation error rates remain comparable. These characteristics are necessary and sufficient for the essentially de novo emergence of a coupled gene–replicase–translatase system of genetic coding that would have continuously preserved the functional meaning of genetically encoded protein genes whose phylogenetic relationships match those observed today.
Asymptomatic Bone Marrow Edema Detected by 67Ga Scintigraphy
Authors: Shinji Miwa, Takanobu Otsuka, Satoshi Yamada, Hisaki Aiba, Hiroyuki Tsuchiya
Journal: Clinical Nuclear Medicine (2019)

Abstract A 46-year-old woman presented with a complaint of fever. CRP was 2.1 mL/L in blood, white blood cell count was 20–29/hpf, and bacterial count was 3418/μL in a urinalysis. 67 Ga scan revealed accumulation of 67 Ga in the left distal femur, although she had no symptoms around the site. MRI demonstrated diffuse high signal intensity on T2-weighted STIR images. Osteomyelitis was suspected, and biopsy was performed. Bacterial culture of the bone marrow was negative, and histological examination showed no infiltration of inflammatory cells. Two months after the biopsy, disappearance of altered signal intensity of MRI was observed.
SP0042 FROM PAEDIATRIC CARE TO ADULT CARE – THE NEEDS OF YOUNG PEOPLE, AND HOW HEALTHCARE PROFESSIONALS CAN FACILITATE OPTIMAL TRANSITION
Authors: Judy Ammerlaan
Journal: Annals of the Rheumatic Diseases (2019)

<h3></h3> In this presentation, the learning experiences and reflections of a healthcare team on redeveloping the transitional care for young adults with RMD"s are shared. In the process of redeveloping care, the healthcare team experienced that small steps, driven by patient stories and involvement of patients in all phases from development to evaluation, led to meaningful results. The eHealth interventions, developed to support the transition and to increase self-management were found to be feasible and evaluated positively by the young adult group. But the healthcare team also experienced that the focus on the patient alone, is not enough to implement self-management interventions and sustain patient centered care in daily practice. How healthcare professionals personally think and feel about patient centered care is essential and needs to be discussed in daily care. It determines the way of being present with attention and commitment in daily health care. It affects the hands, head and heart. A daily reflection on shared answers of the patient and the health care professional to the question 'what is the most important to you?" may help to implement patient centered care in health practice. <h3>Disclosure of Interests:</h3> None declared
THU0587 COMPARING OF TWO DISTINCT SEVERITY SCORES FOR EVALUATING DISEASE SEVERITY IN FAMILIAL MEDITERRANEAN FEVER
Authors: Emre Tekgoz, Seda Colak, Fatma İlknur Cinar, Sedat Yilmaz, Muhammet Çınar
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> Familial Mediterranean Fever (FMF) is a chronic hereditary disease which is characterized by recurrent attacks of fever accompanied by serositis. Severity of disease is related with morbidities such as amyloidosis and chronic renal failure. <h3>Objectives</h3> The aim of this study was to evaluate disease severity with two disease severity scores in FMF patients, and compare them. <h3>Methods</h3> The study included 160 patients with FMF. Demographic and clinical data were recorded in the patients' form. The patients' disease severity were evaluated with International Severity Scoring System for FMF (ISSF) and The Second Set of FMF severity score (F-SS-2). <h3>Results</h3> A total of 160 patients, comprising of 106 males (66.3%) and 54 (33.8%) females with a mean age of 33.5 ± 12.2 years were evaluated. Mean disease duration was 16.6 ± 10.3 years. Other demographic and clinical characteristics of the patients were shown in Table 1. According to ISSF, 67 (41.9%) patients were classified as having mild disease, 80 (50.0%) patients as intermediate disease and 13 (8.1%) patients as severe disease. On the other hand, 59 (36.9%) patients were classified as having mild disease, 41 (25.6%) patients as intermediate disease and 60 (37.5%) patients as severe disease according to F-SS-2 score. Higher rates of patients were found having severe disease according to F-SS-2 compared with ISSF (p&lt;0.001). Also, lower rates of patients were scored as having intermediate disease with F-SS-2 compared with ISSF (p&lt;0.001) (Table 2). F-SS-2: The second set of Familial Mediterranean Fever severity score, ISSF: International Severity Scoring System for Familial Mediterranean Fever, <sup>a</sup>Pearson Chi-Square test <h3>Conclusion</h3> Disease severity scores should be used for treatment choice, evaluation of disease prognosis and classify patients according to disease severity in clinical trials. In the current study, we found a difference between the classifications of disease severity, which could be a result of each scoring system uses different parameters of the disease. <h3>Disclosure of Interests</h3> None declared
Abstract 16486: Omega-3 Polyunsaturated Fatty Acids Suppresses Development of Abdominal Aortic Aneurysm in Apoe-deficient Mice by Shifting the Balance of Macrophages From M1 to M2
Authors: Takuma Yoshihara
Journal: Circulation (2013)

Background: Dietary intake of omega-3 polyunsaturated fatty acids (ω3-PUFAs) reduces initiation and progression of atherosclerosis and prevents cardiovascular events. Macrophages have heterogeneous...
PB2346 RISK FACTORS ANALYSIS FOR DISEASE RECURRENCE AFTER ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION IN PATIENTS WITH HIGH‐RISK ACUTE LEUKEMIA
Authors: R. Zhang, Q. Wu, Z. Jiang, D. Wan, L. Li, L. Xia
Journal: HemaSphere (2019)

Background: Relapse is a major cause of treatment failure for high‐risk acute leukemia after allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Prognosis is considered dismal but data about risk factors associated with disease recurrence have not been elucidated. Aims: We aim to explore the pre‐ and post‐transplantation risk factors on relapse and survival in order to formulate individualized prophylaxis and treatment protocol for primary reoccurrence in high‐risk patients before and after transplantation. Methods: We retrospectively analyzed the outcomes of 321 high‐risk acute leukemia patients who underwent allogeneic hematopoietic stem cell transplantation (allo‐HSCT) who were diagnosed and treated at Union Hospital, and further evaluated the impact of pre‐ and post‐transplantation risk factors on relapse and survival by multivariate analysis. Results: Overall, 104 patients relapsed after allo‐HSCT with relapse cumulative incidence of 31 ± 2%. The median time of relapse was 4 (1.5‐26) months. With a median follow‐up of 50 months, the 3‐year overall survival (OS) and disease‐free survival (DFS) were 70%, 60%, respectively. Multivariate analysis showed that conditioning regimen (HR, 0.309; 95% CI, 0.119‐0.806, p = 0.016), type of disease (HR, 0.335; 95% CI, 0.125‐0.896, p = 0.029), and disease status at transplantation (HR, 1.964; 95% CI, 1.156‐3.338, p = 0.013) were independent factors influencing relapse for high‐risk acute leukemia patients following allo‐HSCT. Summary/Conclusion: Since the prognosis of patients with acute leukemia who experienced relapse after allo‐HSCT was poor, we emphasize the urgent need for formulating individualized prophylaxis and treatment protocol for primary reoccurrence in high‐risk patients before and after transplantation.
Infographic. Progressing rehabilitation after injury: consider the ‘control-chaos continuum’
Authors: Matt Taberner, Tom Allen, Daniel Dylan Cohen
Journal: British Journal of Sports Medicine (2019)

Return to sport (RTS) is a dynamic process, during which practitioners must balance the risk that early reintegration to training/match-play increases reinjury risk with the benefit to the team of having key players available.1 Medical and performance staff must work together to formulate a plan considering the individual, the specifics of the injury, tissue healing time and potential risk factors for reinjury.



A key element of this plan is the management and prescription of external running loads using global positioning systems (GPS) to return players to previous levels of chronic load prior to injury, relatively quickly and safely.2 3 Alongside …
Experimental Support That Natural Selection Has Shaped the Latitudinal Distribution of Mitochondrial Haplotypes in Australian Drosophila melanogaster
Authors: M. Florencia Camus, Jonci N. Wolff, Carla M. Sgrò, Damian K. Dowling
Journal: Molecular Biology and Evolution (2017)

Cellular metabolism is regulated by enzyme complexes within the mitochondrion, the function of which are sensitive to the prevailing temperature. Such thermal sensitivity, coupled with the observation that population frequencies of mitochondrial haplotypes tend to associate with latitude, altitude, or climatic regions across species distributions, led to the hypothesis that thermal selection has played a role in shaping standing variation in the mitochondrial DNA (mtDNA) sequence. This hypothesis, however, remains controversial, and requires evidence that the distribution of haplotypes observed in nature corresponds with the capacity of these haplotypes to confer differences in thermal tolerance. Specifically, haplotypes predominating in tropical climates are predicted to encode increased tolerance to heat stress, but decreased tolerance to cold stress. We present direct evidence for these predictions, using mtDNA haplotypes sampled from the Australian distribution of Drosophila melanogaster. We show that the ability of flies to tolerate extreme thermal challenges is affected by sequence variation across mtDNA haplotypes, and that the thermal performance associated with each haplotype corresponds with its latitudinal prevalence. The haplotype that predominates at low (subtropical) latitudes confers greater resilience to heat stress, but lower resilience to cold stress, than haplotypes predominating at higher (temperate) latitudes. We explore molecular mechanisms that might underlie these responses, presenting evidence that the effects are in part regulated by SNPs that do not change the protein sequence. Our findings suggest that standing variation in the mitochondrial genome can be shaped by thermal selection, and could therefore contribute to evolutionary adaptation under climatic stress.