tbuckley/cabot-search huggingface dataset:
miR-142 controls metabolic reprogramming that regulates dendritic cell activation
Authors: Yaping Sun, Katherine Oravecz-Wilson, Sydney Bridges, Richard McEachin, Julia Wu, Stephanie H. Kim, Austin Taylor, Cynthia Zajac, Hideaki Fujiwara, Daniel Christopher Peltier, Thomas Saunders, Pavan Reddy
Journal: Journal of Clinical Investigation (2019)

DCs undergo metabolic reprogramming from a predominantly oxidative phosphorylation (OXPHOS) to glycolysis to mount an immunogenic response. The mechanism underpinning the metabolic reprogramming remains elusive. We demonstrate that miRNA-142 (miR-142) is pivotal for this shift in metabolism, which regulates the tolerogenic and immunogenic responses of DCs. In the absence of miR-142, DCs fail to switch from OXPHOS and show reduced production of proinflammatory cytokines and the ability to activate T cells in vitro and in in vivo models of sepsis and alloimmunity. Mechanistic studies demonstrate that miR-142 regulates fatty acid (FA) oxidation, which causes the failure to switch to glycolysis. Loss- and gain-of-function experiments identified carnitine palmitoyltransferase -1a (CPT1a), a key regulator of the FA pathway, as a direct target of miR-142 that is pivotal for the metabolic switch. Thus, our findings show that miR-142 is central to the metabolic reprogramming that specifically favors glycolysis and immunogenic response by DCs.
Outbreak of Salmonella enterica serotype Poona in infants linked to persistent Salmonella contamination in an infant formula manufacturing facility, France, August 2018 to February 2019
Authors: Gabrielle Jones, Maria Pardos de la Gandara, Laura Herrera-Leon, Silvia Herrera-Leon, Carmen Varela Martinez, Roselyne Hureaux-Roy, Yasmine Abdallah, Athinna Nisavanh, Laetitia Fabre, Charlotte Renaudat, Joël Mossong, Wesley Mattheus, Cécile Huard, Caroline Le Borgne, Henriette de Valk, François-Xavier Weill, Nathalie Jourdan-Da Silva
Journal: Eurosurveillance (2019)

We describe a Salmonella Poona outbreak involving 31 infant cases in France. Following outbreak detection on 18 January 2019, consumption of rice-based infant formula manufactured at a facility in Spain was identified as the probable cause, leading to a recall on 24 January. Whole genome sequencing analysis linked present outbreak isolates to a 2010–11 S. Poona outbreak in Spain associated with formula manufactured in the same facility, indicating a persistent source of contamination.
Estrogen Receptor Covalent Antagonists: The Best Is Yet to Come
Authors: Craig Furman, Ming-Hong Hao, Sudeep Prajapati, Dominic Reynolds, Victoria Rimkunas, Guo Z. Zheng, Ping Zhu, Manav Korpal
Journal: Cancer Research (2019)

The development of tamoxifen and subsequent estrogen receptor alpha (ERα) antagonists represents a tremendous therapeutic breakthrough in the treatment of breast cancer. Despite the ability of ERα antagonists to increase survival rates, resistance to these therapies is an all-too-common occurrence. The majority of resistant tumors, including those with hotspot mutations in the ligand-binding domain of ERα, remain dependent on ERα signaling, indicating that either a more potent or novel class of antagonist could have clinical benefit. With this thought in mind, we developed a novel ERα antagonist that exhibits enhanced potency due to its ability to covalently target a unique cysteine in ER. This review describes the design of this antagonist, H3B-5942, and discusses opportunities for future improvements, which could reduce the risk of escape mutations to this therapeutic modality.
QOF now accounts for less than 10% of GP practice income
Authors: Tom Moberly, Will Stahl-Timmins
Journal: BMJ (2019)

Quality incentive payments now account for less than 10% of GP practice income, NHS Digital figures show.1

There are also wide geographical variations in how much income practices get from such incentives, analysis of the data reveals.



Quality indicators accounted for 15-20% of practice income in the years after the introduction of the …
A Common Purpuric Rash With Uncommon Association in a Woman With Pedal Edema
Authors: Tauseef Akhtar, Ankit Mangla
Journal: JAMA Oncology (2019)

A 70-year-old woman with pedal edema and a history of smoking presented with multiple well-defined, palpable, purpuralike lesions on the lower extremities that gradually extended to the trunk. What is your diagnosis?
Barriers to Kidney Transplant—The Devil Is in the Details
Authors: Madison C. Cuffy, Shimul A. Shah
Journal: JAMA Surgery (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Nanotechnology‐Mediated Drug Delivery for the Treatment of Obesity and Its Related Comorbidities
Authors: Yung‐Hao Tsou, Bin Wang, William Ho, Bin Hu, Pei Tang, Sydney Sweet, Xue‐Qing Zhang, Xiaoyang Xu
Journal: Advanced Healthcare Materials (2019)

Abstract Obesity is a serious health issue affecting humanity on a global scale. Recognized by the American Medical Association as a chronic disease, the incidence of obesity continues to grow at an accelerating rate and obesity has become one of the major threats to human health. Excessive weight gain is tied to metabolic syndrome, which is shown to increase the risk of chronic diseases, such as heart disease and type 2 diabetes, taxing an already overburdened healthcare system and increasing mortality worldwide. Available treatments such as bariatric surgery and pharmacotherapy are often accompanied by adverse side effects and poor patient compliance. Nanotechnology, an emerging technology with a wide range of biomedical applications, has provided an unprecedented opportunity to improve the treatment of many diseases, including obesity. This review provides an introduction to obesity and obesity‐related comorbidities. The most recent developments of nanotechnology‐based drug delivery strategies are highlighted and discussed. Additionally, challenges and consideration for the development of nanoformulations with translational potential are discussed. The overall objective of this review is to enhance the understanding of the design and development of nanomedicine for treatments of obesity and related comorbidities.
HG in keratinocytes and the impact of KdPT
Authors: P. Gkogkolou, M. Sarna, T. Sarna, R. Paus, T.A. Luger, M. Böhm
Journal: British Journal of Dermatology (2019)

Diabetes is a common disease affecting millions of people worldwide. It is characterized by increased glucose concentrations in the blood and body. Chronic foot ulcers are one of the most serious complications in diabetes, affecting up to 10% of diabetic patients. Treatment of these ulcers remains difficult, resulting in high costs for healthcare systems as well as increased mortality in patients. This study from Germany aimed to characterize the effects of high glucose on epidermal keratinocytes, the cells of the outermost layer of the skin and a key cell type for wound healing. Furthermore, it examined if a small molecule, called KdPT, can protect keratinocytes from glucose‐induced stress and toxicity. The authors investigated various functions of keratinocytes under high‐glucose conditions with or without KdPT in cell culture models as well as in skin biopsies from healthy subjects. High glucose reduced cell proliferation and viability (meaning it caused a decrease in the number of cells, and a decrease in the number of healthy cells), and migration (cellular movement) of keratinocytes. It also altered the cell size and elasticity. Parallel to these changes, increased amounts of reactive oxygen species, which are toxic to cells, as well as intracellular stress were observed. However, KdPT reduced some of these negative effects of high glucose. The authors’ findings highlight a novel effect of KdPT, which could be used to develop new treatments for diabetic skin ulcers.
Initial Results from a Cohort in a Phase 2a Study (GBT440-007) Evaluating Adolescents with Sickle Cell Disease Treated with Multiple Doses of GBT440, a HbS Polymerization Inhibitor
Authors: Carolyn C Hoppe, Adlette C. Inati, Clark Brown, Winfred Wang, Victor R. Gordeuk, Robert Liem, Gerald Woods, Connie M. Piccone, Erica Fong, Ganesh Balaratnam, Sandy Dixon, Margaret E Tonda, Carla B Washington, Yifah Yaron, Josh Lehrer
Journal: Blood (2017)
Influenza vaccination and myocarditis among patients receiving immune checkpoint inhibitors
Authors: Magid Awadalla, Doll Lauren Alexandra Golden, Syed S. Mahmood, Raza M. Alvi, Nathaniel D. Mercaldo, Malek Z. O. Hassan, Dahlia Banerji, Adam Rokicki, Connor Mulligan, Sean P. T. Murphy, Maeve Jones-O’Connor, Justine V. Cohen, Lucie M. Heinzerling, Merna Armanious, Ryan J. Sullivan, Rongras Damrongwatanasuk, Carol L. Chen, Dipti Gupta, Michael C. Kirchberger, Javid J. Moslehi, Sachin P. Shah, Sarju Ganatra, Paaladinesh Thavendiranathan, Muhammad A. Rizvi, Gagan Sahni, Alexander R. Lyon, Carlo G. Tocchetti, Valentina Mercurio, Franck Thuny, Stephane Ederhy, Michael Mahmoudi, Donald P. Lawrence, John D. Groarke, Anju Nohria, Michael G. Fradley, Kerry L. Reynolds, Tomas G. Neilan
Journal: Journal for ImmunoTherapy of Cancer (2019)

Influenza vaccination (FV) is recommended for patients with cancer. Recent data suggested that the administration of the FV was associated with an increase in immune-related adverse events (irAEs) among patients on immune checkpoint inhibitors (ICIs). Myocarditis is an uncommon but serious complication of ICIs and may also result from infection with influenza. There are no data testing the relationship between FV and the development of myocarditis on ICIs.Patients on ICIs who developed myocarditis (n = 101) (cases) were compared to ICI-treated patients (n = 201) without myocarditis (controls). A patient was defined as having the FV if they were administered the FV from 6 months prior to start of ICI to anytime during ICI therapy. Alternate thresholds for FV status were also tested. The primary comparison of interest was the rate of FV between cases and controls. Patients with myocarditis were followed for major adverse cardiac events (MACE), defined as the composite of cardiogenic shock, cardiac arrest, hemodynamically significant complete heart block and cardiovascular death.The FV was administered to 25% of the myocarditis cases compared to 40% of the non-myocarditis ICI-treated controls (p = 0.01). Similar findings of lower rates of FV administration were noted among myocarditis cases when alternate thresholds were tested. Among the myocarditis cases, those who were vaccinated had 3-fold lower troponin levels when compared to unvaccinated cases (FV vs. No FV: 0.12 [0.02, 0.47] vs. 0.40 [0.11, 1.26] ng/ml, p = 0.02). Within myocarditis cases, those administered the FV also had a lower rate of other irAEs when compared to unvaccinated cases (36 vs. 55% p = 0.10) including lower rates of pneumonitis (12 vs. 36%, p = 0.03). During follow-up (175 [IQR 89, 363] days), 47% of myocarditis cases experienced a MACE. Myocarditis cases who received the FV were at a lower risk of cumulative MACE when compared to unvaccinated cases (24 vs. 59%, p = 0.002).The rate of FV among ICI-related myocarditis cases was lower than controls on ICIs who did not develop myocarditis. In those who developed myocarditis related to an ICI, there was less myocardial injury and a lower risk of MACE among those who were administered the FV.
Abstract 16451: Identifying Gaps in Primary Prevention of Sudden Cardiac Arrest
Authors: Victor Waldmann, Wulfran Bougouin, Ardalan Sharifzadehgan, Kumar Narayanan, Nicole Karam, Florence Dumas, Lionel Lamhaut, Daniel Jost, Alain Cariou, Xavier Jouven, Eloi Marijon
Journal: Circulation (2017)

Introduction: Despite continuous improvements in resuscitation care, outcomes after the occurrence of a sudden cardiac arrest (SCA) remain poor. Optimization of primary prevention strategies is crucial. Hypothesis: Specific gaps in SCA primary prevention exist whose identification can help plan targeted strategies. Methods: From May 2011 to May 2016, all cases of SCA admitted alive in intensive care units in our registry (covering a residential population of 6.7 million inhabitants), were prospectively included. Their medical histories were gathered and analyzed by a specific working group, in order to identify missed opportunities for SCA primary prevention. Results: Among 18,662 out-of-hospital cardiac arrests, 3,028 patients admitted alive to hospital fulfilled the SCA definition, and coronary artery disease represented the principal cause of SCA (79.3%). Overall, 2,244 (74.1%) patients had a least one known modifiable cardiovascular risk factor, mainly hypertension, obesity and smoking. Overall, 927 p...
Biological Studies on Stable and Radioactive Rare Earth Compounds. I. On the Distribution of Lanthanum in the Mammalian Organism&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: Daniel Laszlo, Daniel M. Ekstein, Ruth Lewin, Kurt G. Stern
Journal: JNCI Journal of the National Cancer Institute (1952)

Journal Article Biological Studies on Stable and Radioactive Rare Earth Compounds. I. On the Distribution of Lanthanum in the Mammalian Organism Get access Daniel Laszlo, Daniel Laszlo Division of Neoplastic Diseases, Montefiore Hospital, New York, N. Y., and the Departments of Chemistry and Physics, Polytechnic Institute of Brooklyn, Brooklyn, N. Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar Daniel M. Ekstein, Daniel M. Ekstein Division of Neoplastic Diseases, Montefiore Hospital, New York, N. Y., and the Departments of Chemistry and Physics, Polytechnic Institute of Brooklyn, Brooklyn, N. Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar Ruth Lewin, Ruth Lewin Division of Neoplastic Diseases, Montefiore Hospital, New York, N. Y., and the Departments of Chemistry and Physics, Polytechnic Institute of Brooklyn, Brooklyn, N. Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar Kurt G. Stern Kurt G. Stern Division of Neoplastic Diseases, Montefiore Hospital, New York, N. Y., and the Departments of Chemistry and Physics, Polytechnic Institute of Brooklyn, Brooklyn, N. Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 13, Issue 2, October 1952, Pages 559–573, https://doi.org/10.1093/jnci/13.2.559 Published: 01 October 1952 Article history Received: 03 July 1952 Published: 01 October 1952
Abstract 11663: The Features of Hypertensive Heart Failure With Preserved Ejection Fraction Assessed by 3-Dimensional Speckle Tracking Echocardiography With Novel Software
Authors: Noriaki Sato, Masanori Kawasaki, Michael R Zile, Ryuhei Tanaka, Shingo Minatoguchi, Takatomo Watanabe, Koji Ono, Maki Saeki, Maki Nagaya, Noriyuki Onishi, Kazuo Amano, Tai Kojima, Shunichiro Warita, Makoto Iwama, Toshiyuki Noda, Hidemaro Sato, Sachiro Watanabe, Helene Houle, Shinya Minatoguchi
Journal: Circulation (2014)

Background: Left ventricular (LV) pressure overload causes hypertrophy (LVH), which leads to reduced LV relaxation and compliance and results in heat failure with preserved ejection fraction (HFpEF...
Bill Jenkins: epidemiologist and activist who blew the whistle on the US government’s Tuskegee syphilis study
Authors: Rebecca Wallersteiner
Journal: BMJ (2019)

Photo courtesy of the American Friends Service Committee

William (“Bill”) Carter Jenkins was born in Mt Pleasant, South Carolina, in the US, in 1945, the son of Albert Jenkins, an undertaker and restaurant owner, and his wife, Martha, a schoolteacher. He excelled at high school, where he read assiduously and developed an interest in science and political activism. He graduated from the historically black Morehouse College, in Atlanta, Georgia, with a bachelor’s degree in mathematics, and, in the 1960s, was one of the first African-Americans recruited to the National Center for Health Statistics, a branch of the public health service. He received a doctorate in epidemiology from the University of North Carolina in 1983 and did postdoctoral work in biostatistics at Harvard University School of Public Health. Also in 1983 he married fellow epidemiologist Diane Rowley, and they enjoyed a happy marriage.

Rowley said that her husband had been an activist since school when he registered people to vote. At college, in the 1960s, he was a foot soldier in the Student Nonviolent Coordinating Committee and was imprisoned, along with future Georgia congressman John Lewis, for demonstrating against a white only restaurant. Later, Jenkins helped found an underground publication, The Drum , dealing with problems of racism and inequality at work. He is best known for blowing the whistle on the Tuskegee syphilis study, while still a government employee.

Jenkins had started a promising career at the US Public Health …
Statement paper on diversity for the European Society of Intensive Care Medicine (ESICM)
Authors: Bjoern Weiss
Journal: Intensive Care Medicine (2019)

Diversity has become a key-strategic element of success in various political and economic fields. The European Society of Intensive Care Medicine (ESICM) decided to make diversity a key strategic priority for the future and appointed a Task-Force on this topic. In a consensus process, three Working-Groups, nominated by Task-Force members, developed statements on strategic future topics. In addition, diversity-related data available from the membership database have been analyzed and reported in aggregated form. The Task-Force decided to nominate working groups on (1) "sex, gender identity and sexual orientation", (2) "ethnicity, culture and socio-economic status", and (3) "multiprofessionalism". These are the first prioritized topics for the near future. The first diversity-report shows targetable items in all three domains. The diversity Task-Force defined actionable items for a one- and three-year plan that are especially aiming at the identification of potential gaps and an implementation of concrete projects for members of the ESICM.
Early Sexual Initiation Among Boys
Authors: David L. Bell, Samantha Garbers
Journal: JAMA Pediatrics (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Mass Shootings and the Numbing of America
Authors: Eric Fleegler
Journal: JAMA Internal Medicine (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Phase Ib study of atezolizumab combined with cobimetinib in patients with solid tumors
Authors: M.D. Hellmann, T.-W. Kim, C.B. Lee, B.-C. Goh, W.H. Miller, D.-Y. Oh, R. Jamal, C.-E. Chee, L.Q.M. Chow, J.F. Gainor, J. Desai, B.J. Solomon, M. Das Thakur, B. Pitcher, P. Foster, G. Hernandez, M.J. Wongchenko, E. Cha, Y.-J. Bang, L.L. Siu, J. Bendell
Journal: Annals of Oncology (2019)