tbuckley/cabot-search huggingface dataset:
Megakaryocytes promote bone formation through coupling osteogenesis with angiogenesis by secreting TGF-β1
Authors: Yong Tang, Mengjia Hu, Yang Xu, Fang Chen, Shilei Chen, Mo Chen, Yan Qi, Mingqiang Shen, Cheng Wang, Yukai Lu, Zihao Zhang, Hao Zeng, Yong Quan, Fengchao Wang, Yongping Su, Dongfeng Zeng, Song Wang, Junping Wang
Journal: Theranostics (2020)

Rationale: The hematopoietic system and skeletal system have a close relationship, and megakaryocytes (MKs) may be involved in maintaining bone homeostasis. However, the exact role and underlying mechanism of MKs in bone formation during steady-state and stress conditions are still unclear. Methods: We first evaluated the bone phenotype with MKs deficiency in bone marrow by using c-Mpl-deficient mice and MKs-conditionally deleted mice. Then, osteoblasts (OBs) proliferation and differentiation and CD31hiEmcnhi tube formation were assessed. The expression of growth factors related to bone formation in MKs was detected by RNA-sequencing and enzyme-linked immunosorbent assays (ELISAs). Mice with specific depletion of TGF-β1 in MKs were used to further verify the effect of MKs on osteogenesis and angiogenesis. Finally, MKs treatment of irradiation-induced bone injury was tested in a mouse model. Results: We found that MKs deficiency significantly impaired bone formation. Further investigations revealed that MKs could promote OBs proliferation and differentiation, as well as CD31hiEmcnhi vessels formation, by secreting high levels of TGF-β1. Consistent with these findings, mice with specific depletion of TGF-β1 in MKs displayed significantly decreased bone mass and strength. Importantly, treatment with MKs or thrombopoietin (TPO) substantially attenuated radioactive bone injury in mice by directly or indirectly increasing the level of TGF-β1 in bone marrow. MKs-derived TGF-β1 was also involved in suppressing apoptosis and promoting DNA damage repair in OBs after irradiation exposure. Conclusions: Our findings demonstrate that MKs contribute to bone formation through coupling osteogenesis with angiogenesis by secreting TGF-β1, which may offer a potential therapeutic strategy for the treatment of irradiation-induced osteoporosis.
Homicide During Pregnancy and the Postpartum Period in Louisiana, 2016-2017
Authors: Maeve E. Wallace, Joia Crear-Perry, Pooja K. Mehta, Katherine P. Theall
Journal: JAMA Pediatrics (2020)

This study examines the incidence of homicide as the cause of mortality in women who are pregnant or post partum in Louisiana in 2016 through 2017, comparing this with other causes of maternal mortality.
New Insights Into Intestinal Failure–Associated Liver Disease in Children
Authors: Racha T. Khalaf, Ronald J. Sokol
Journal: Hepatology (2020)

Development of intestinal failure–associated liver disease (IFALD) is a common complication of long‐term parenteral nutrition (PN) in children and adults. The molecular and cellular mechanisms and the phases of IFALD are now being delineated. Components of PN lipid emulsions, including plant sterols, interact with hepatic innate immune activation promoted by products of gut bacterial overgrowth/dysbiosis and altered intestinal barrier function (gut‐liver axis) and by episodes of sepsis to cause cholestasis and IFALD. New therapeutic strategies, including modifications of intravenous lipid emulsions to reduce pro‐inflammatory fatty acids and plant sterol content, can lower the risk of IFALD, reverse cholestasis, and reduce complications, although the significance of persisting hepatic fibrosis is unknown. This review will provide an update on advances in the pathogenesis of IFALD, newer therapeutic and preventative strategies, and challenges that confront managing patients with IFALD.
Cytokine release syndrome (CRS) following treatment with tebentafusp, a novel bispecific TCR-anti-CD3 directed against gp100, in patients with advanced melanoma
Authors: A Shoushtari, M Middleton, N Stevens, T Evans, J Infante, M Sznol, A Anthoney, A Gupta, V Woodcock, T Wiseman, C McAlpine, C Cohen, O Hamid
Journal: Journal for ImmunoTherapy of Cancer (2019)
B7-H7 (HHLA2) inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling
Authors: Sadiye Amcaoglu Rieder, Jingya Wang, Natalie White, Ariful Qadri, Catherine Menard, Geoffrey Stephens, Jodi L. Karnell, Christopher E. Rudd, Roland Kolbeck
Journal: Cellular and Molecular Immunology (2020)

Modulation of T-cell responses has played a key role in treating cancers and autoimmune diseases. Therefore, understanding how different receptors on T cells impact functional outcomes is crucial. The influence of B7-H7 (HHLA2) and CD28H (TMIGD2) on T-cell activation remains controversial. Here we examined global transcriptomic changes in human T cells induced by B7-H7. Stimulation through TCR with OKT3 and B7-H7 resulted in modest fold changes in the expression of select genes; however, these fold changes were significantly lower than those induced by OKT3 and B7-1 stimulation. The transcriptional changes induced by OKT3 and B7-H7 were insufficient to provide functional stimulation as measured by evaluating T-cell proliferation and cytokine production. Interestingly, B7-H7 was coinhibitory when simultaneously combined with TCR and CD28 stimulation. This inhibitory activity was comparable to that observed with PD-L1. Finally, in physiological assays using T cells and APCs, blockade of B7-H7 enhanced T-cell activation and proliferation, demonstrating that this ligand acts as a break signal. Our work defines that the transcriptomic changes induced by B7-H7 are insufficient to support full costimulation with TCR signaling and, instead, B7-H7 inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling.
Phase II Study of Two Eribulin Regimens in Combination with Erlotinib in Patients (PTS) with Previously Treated Advanced Non-Small Cell Lung Cancer (NSCLC)
Authors: S.L. Geater, N. Ianotti, S. Thongprasert, A. Spira, D. Smith, V. Lee, W.-T. Lim, P. Gopalakrishna, C. Reynolds, T.S.K. Mok
Journal: Annals of Oncology (2012)
Mapping global variation in dengue transmission intensity
Authors: Lorenzo Cattarino, Isabel Rodriguez-Barraquer, Natsuko Imai, Derek A. T. Cummings, Neil M. Ferguson
Journal: Science Translational Medicine (2020)

Intervention planning for dengue requires reliable estimates of dengue transmission intensity. However, current maps of dengue risk provide estimates of disease burden or the boundaries of endemicity rather than transmission intensity. We therefore developed a global high-resolution map of dengue transmission intensity by fitting environmentally driven geospatial models to geolocated force of infection estimates derived from cross-sectional serological surveys and routine case surveillance data. We assessed the impact of interventions on dengue transmission and disease using Wolbachia-infected mosquitoes and the Sanofi-Pasteur vaccine as specific examples. We predicted high transmission intensity in all continents straddling the tropics, with hot spots in South America (Colombia, Venezuela, and Brazil), Africa (western and central African countries), and Southeast Asia (Thailand, Indonesia, and the Philippines). We estimated that 105 [95% confidence interval (CI), 95 to 114] million dengue infections occur each year with 51 (95% CI, 32 to 66) million febrile disease cases. Our analysis suggests that transmission-blocking interventions such as Wolbachia, even at intermediate efficacy (50% transmission reduction), might reduce global annual disease incidence by up to 90%. The Sanofi-Pasteur vaccine, targeting only seropositive recipients, might reduce global annual disease incidence by 20 to 30%, with the greatest impact in high-transmission settings. The transmission intensity map presented here, and made available for download, may help further assessment of the impact of dengue control interventions and prioritization of global public health efforts.
Upfront Treatment Influences the Composition of Genetic Alterations in Relapsed Pediatric B‐Cell Precursor Acute Lymphoblastic Leukemia
Authors: Jiangyan Yu, Esmé Waanders, Simon V. van Reijmersdal, Željko Antić, Charlotte M. van Bosbeek, Edwin Sonneveld, Hester de Groot, Marta Fiocco, Ad Geurts van Kessel, Frank N. van Leeuwen, Rob Pieters, Peter M. Hoogerbrugge, Roland P. Kuiper
Journal: HemaSphere (2020)

Genomic alterations in relapsed B-cell precursor acute lymphoblastic leukemia (BCP-ALL) may provide insight into the role of specific genomic events in relapse development. Along this line, comparisons between the spectrum of alterations in relapses that arise in different upfront treatment protocols may provide valuable information on the association between the tumor genome, protocol components and outcome. Here, we performed a comprehensive characterization of relapsed BCP-ALL cases that developed in the context of 3 completed Dutch upfront studies, ALL8, ALL9, and ALL10. In total, 123 pediatric BCP-ALL relapses and 77 paired samples from primary diagnosis were analyzed for alterations in 22 recurrently affected genes. We found pronounced differences in relapse alterations between the 3 studies. Specifically, CREBBP mutations were observed predominantly in relapses after treatment with ALL8 and ALL10 which, in the latter group, were all detected in medium risk-treated patients. IKZF1 alterations were enriched 2.2-fold (p = 0.01) and 2.9-fold (p < 0.001) in ALL8 and ALL9 relapses compared to diagnosis, respectively, whereas no significant enrichment was found for relapses that were observed after treatment with ALL10. Furthermore, IKZF1 deletions were more frequently preserved from a major clone at diagnosis in relapses after ALL9 compared to relapses after ALL8 and ALL10 (p = 0.03). These data are in line with previous studies showing that the prognostic value of IKZF1 deletions differs between upfront protocols and is particularly strong in the ALL9 regimen. In conclusion, our data reveal a correlation between upfront treatment and the genetic composition of relapsed BCP-ALL.
Nonexudative Macular Neovascularization Supporting Outer Retina in Age-Related Macular Degeneration
Authors: Ling Chen, Jeffrey D. Messinger, Kenneth R. Sloan, Thomas A. Swain, Yoshimi Sugiura, Lawrence A. Yannuzzi, Christine A. Curcio, K. Bailey Freund
Journal: Ophthalmology (2020)
内臓脂肪は冠攣縮性狭心症の危険因子か? | 文献情報 | J-GLOBAL 科学技術総合リンクセンター
Authors: 園田浩一朗, 池田聡司, 福井純, 中田智夫, 浦田淳吾, 河野茂
Journal: Circulation (2008)
Coronary microvascular dysfunction in hypertrophy and heart failure
Authors: Paolo G Camici, Carsten Tschöpe, Marcelo F Di Carli, Ornella Rimoldi, Sophie Van Linthout
Journal: Cardiovascular Research (2020)

Left ventricular (LV) hypertrophy (LVH) is a growth in left myocardial mass mainly caused by increased cardiomyocyte size. LVH can be a physiological adaptation to physical exercise or a pathological condition either primary, i.e. genetic, or secondary to LV overload. Patients with both primary and secondary LVH have evidence of coronary microvascular dysfunction (CMD). The latter is mainly due to capillary rarefaction and adverse remodelling of intramural coronary arterioles due to medial wall thickening with an increased wall/lumen ratio. An important feature of this phenomenon is the diffuse nature of this remodelling, which generally affects the coronary microvessels in the whole of the left ventricle. Patients with LVH secondary to arterial hypertension can develop both heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF). These patients can develop HFrEF via a 'direct pathway' with an interval myocardial infarction and also in its absence. On the other hand, patients can develop HFpEF that can then progress to HFrEF with or without interval myocardial infarction. A similar evolution towards LV dysfunction and both HFpEF and HFrEF can occur in patients with hypertrophic cardiomyopathy, the most common genetic cardiomyopathy with a phenotype characterized by massive LVH. In this review article, we will discuss both the experimental and clinical studies explaining the mechanisms responsible for CMD in LVH as well as the evidence linking CMD with HFpEF and HFrEF.
Gap-enhanced Raman tags: fabrication, optical properties, and theranostic applications
Authors: Nikolai G. Khlebtsov, Li Lin, Boris N. Khlebtsov, Jian Ye
Journal: Theranostics (2020)

Gap-enhanced Raman tags (GERTs) are emerging probes of surface-enhanced Raman scattering (SERS) spectroscopy that have found promising analytical, bioimaging, and theranostic applications. Because of their internal location, Raman reporter molecules are protected from unwanted external environments and particle aggregation and demonstrate superior SERS responses owing to the strongly enhanced electromagnetic fields in the gaps between metal core-shell structures. In this review, we discuss recent progress in the synthesis, simulation, and experimental studies of the optical properties and biomedical applications of novel spherically symmetrical and anisotropic GERTs fabricated with common plasmonic metals-gold (Au) and silver (Ag). Our discussion is focused on the design and synthetic strategies that ensure the optimal parameters and highest enhancement factors of GERTs for sensing and theranostics. In particular, we consider various core-shell structures with build-in nanogaps to explain why they would benefit the plasmonic GERTs as a superior SERS tag and how this would help future research in clinical analytics and therapeutics.
High-purity weight-bearing magnesium screw: Translational application in the healing of femoral neck fracture
Authors: Shibo Huang, Benjie Wang, Xiuzhi Zhang, Faqiang Lu, Zongpu Wang, Simiao Tian, Dongyi Li, Jiahui Yang, Fang Cao, Liangliang Cheng, Ziqi Gao, Yangde Li, Kairong Qin, Dewei Zhao
Journal: Biomaterials (2020)
From Solo Decision Maker to Multi-Stakeholder Process: A Defense and Recommendations
Authors: David Ozar, Joseph Vukov, Kit Rempala, Rohan Meda
Journal: The American Journal of Bioethics (2020)

Berger (2020) argues effectively that “representativeness is more aptly understood as a variable that is multidimensional and continuous based on relational moral authority,” and also makes some us...
Reply to Liu et al.
Authors: Andrea Tringali, Guido Costamagna
Journal: Endoscopy (2020)

See also: Multiple Stenting of Refractory Pancreatic Duct Strictures in Severe Chronic Pancreatitis: Long-term ResultsEndoscopy 2006; 38(03): 254-259DOI: 10.1055/s-2005-921069 See also: Long-term follow-up after multiple plastic stenting for refractory pancreatic duct strictures in chronic pancreatitisEndoscopy 2019; 51(10): 930-935DOI: 10.1055/a-0959-6163 See also: Treatment for refractory pancreatic duct strictures should follow the guidelinesEndoscopy 2020; 52(02): 155-155DOI: 10.1055/a-1021-8754
RAS pathway influences the number of melanocytic nevi in cardiofaciocutaneous and Costello syndromes
Authors: Maija Kiuru, Jennifer Urban, Guannan Zhu, Iryna Rybak, Jessica R. Terrell, Lihong Qi, John D. McPherson, Ashfaq A. Marghoob, Katherine A. Rauen
Journal: Journal of the American Academy of Dermatology (2020)
Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor
Authors: Vincent Dussupt, Rajeshwer S. Sankhala, Gregory D. Gromowski, Gina Donofrio, Rafael A. De La Barrera, Rafael A. Larocca, Weam Zaky, Letzibeth Mendez-Rivera, Misook Choe, Edgar Davidson, Michael K. McCracken, James D. Brien, Peter Abbink, Hongjun Bai, Aubrey L. Bryan, Candace Hope Bias, Irina Maljkovic Berry, Nubia Botero, Tanya Cook, Nicole A. Doria-Rose, Ariadna Grinyo i Escuer, Justice Akuoku Frimpong, Aviva Geretz, Mayda Hernandez, Bradley S. Hollidge, Ningbo Jian, Kareem Kabra, David J. Leggat, Jinyan Liu, Amelia K. Pinto, Wiriya Rutvisuttinunt, Ian Setliff, Ursula Tran, Samantha Townsley, Benjamin J. Doranz, Morgane Rolland, Adrian B. McDermott, Ivelin S. Georgiev, Rasmi Thomas, Merlin L. Robb, Kenneth H. Eckels, Elizabeth Barranco, Michael Koren, Darci R. Smith, Richard G. Jarman, Sarah L. George, Kathryn E. Stephenson, Dan H. Barouch, Kayvon Modjarrad, Nelson L. Michael, M. Gordon Joyce, Shelly J. Krebs
Journal: Nature Medicine (2020)
A Review on Machine Learning for EEG Signal Processing in Bioengineering
Authors: Mohammad-Parsa Hosseini, Amin Hosseini, Kiarash Ahi
Journal: IEEE Reviews in Biomedical Engineering (2020)

Electroencephalography (EEG) has been a staple method for identifying certain health conditions in patients since its discovery. Due to the many different types of classifiers available to use, the analysis methods are also equally numerous. In this review, we will be examining specifically machine learning methods that have been developed for EEG analysis with bioengineering applications. We reviewed literature from 1988 to 2018 to capture previous and current classification methods for EEG in multiple applications. From this information, we are able to determine the overall effectiveness of each machine learning method as well as the key characteristics. We have found that all the primary methods used in machine learning have been applied in some form in EEG classification. This ranges from Naive-Bayes to Decision Tree/Random Forest, to Support Vector Machine (SVM). Supervised learning methods are on average of higher accuracy than their unsupervised counterparts. This includes SVM and KNN. While each of the methods individually is limited in their accuracy in their respective applications, there is hope that the combination of methods when implemented properly has a higher overall classification accuracy. This paper provides a comprehensive overview of Machine Learning applications used in EEG analysis. It also gives an overview of each of the methods and general applications that each is best suited to.
To include or not include: renal dialysis policy in the era of universal health coverage
Authors: Yot Teerawattananon, Saudamini Vishwanath Dabak, Levina Chandra Khoe, Diana Beatriz S Bayani, Wanrudee Isaranuwatchai
Journal: BMJ (2020)

Expensive treatments such as renal dialysis are a challenge for countries aiming for universal coverage. <b>Yot Teerawattananon and colleagues</b> set out a systematic approach to ensuring it is affordable
癌における拡散強調画像: Restriction Spectrum Imagingの物理学的基礎および適用 | 文献情報 | J-GLOBAL 科学技術総合リンクセンター
Authors: S White Nathan, R Mcdonald Carrie, Farid Niky, Kuperman Josh, Karow David, M Schenker-Ahmed Natalie, Bartsch Hauke, Rakow-Penner Rebecca, Holland Dominic, Shabaik Ahmed, Bjornerud Atle, Hope Tuva, Hattangadi-Gluth Jona, Liss Michael, Parsons J. Kellogg, C Chen Clark, Raman Steve, Margolis Daniel, E Reiter Robert, Marks Leonard, Kesari Santosh, J Mundt Arno, J Kane Christopher, S Carter Bob, G Bradley William, M Dale Anders
Journal: Cancer Research (2014)
Addition of Dornase to Intrapleural Fibrinolytic Therapy Is Not Superior to Fibrinolytic Therapy Alone for Otherwise Healthy Children Hospitalized With Empyema
Authors: Jonathan Kohler, Michelle M. Kelly
Journal: JAMA Pediatrics (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
A Woman in Her 20s With Chest Pain and Arm Claudication
Authors: Jason M. Tarkin, Deepa Gopalan, Justin C. Mason
Journal: JAMA Cardiology (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Annals Graphic Medicine - Firearm Injuries and MRI Safety
Authors: Michael U. Antonucci
Journal: Annals of Internal Medicine (2020)

Web Exclusives4 February 2020Annals Graphic Medicine - Firearm Injuries and MRI SafetyFREEMichael U. Antonucci, MDMichael U. Antonucci, MDAffiliation (M.U.A.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/G19-0033 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Download figure Download PowerPoint Download figure Download PowerPoint Download figure Download PowerPoint Download figure Download PowerPoint Download figure Download PowerPoint Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: Affiliation (M.U.A.)Disclosures: The author has disclosed no conflicts of interest. His form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=G19-0033.Author/Illustrator Information: Michael U. Antonucci, MD, is the clinical director of MRI Safety at the Medical University of South Carolina (e-mail, [email protected]edu). In this capacity, he addresses multiple issues, including assessing the potential risks of MRI in patients with implanted devices and retained metallic fragments. This Graphic Medicine submission was conceived following 4 sequential MRI requests in patients with residual bullet fragments over a 2-day period. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 4 February 2020Volume 172, Issue 3Page: W49-W54KeywordsConflicts of interestDisclosureFire safetyFirearm injuriesHealth careSafety ePublished: 4 February 2020 Issue Published: 4 February 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...