tbuckley/cabot-search huggingface dataset:
A Retrospective Single Centre Analysis of Safety, Toxicity and Efficacy of Rituximab (ORIGINAL) and Its Biosimilar in Diffuse Large B-Cell Lymphoma Patients Treated with Chemo-Immunotherapy
Authors: P.S. Roy, M. Sengar, H. Menon, B. Bagal, N. Khattry, E. Shridhar, S. Gujral, S. Laskar, V. Rangarajan,, R. Nair
Journal: Annals of Oncology (2012)
ARN-509 in Men with Metastatic Castration-Resistant Prostate Cancer (CRPC)
Authors: D. Rathkopf, E.S. Antonarakis, N.D. Shore, R. Tutrone, J. Alumkal, C.J. Ryan, M. Saleh, R. Hauke, E. Chow-Maneval, H.I. Scher
Journal: Annals of Oncology (2012)
PYK2ノックアウトマウスによって暴露されたeNOS介在血管形成におけるカルシウム依存チロシンキナーゼPYK2の中心的役割 | 文献情報 | J-GLOBAL 科学技術総合リンクセンター
Authors: Matsui Akihiro, Okigaki Mitsuhiko, Urao Norifumi, Che Jishan, Nishikawa Susumu, Yamada Hiroyuki, Matsubara Hiroaki
Journal: Circulation (2006)
Comparing Risk Scores in the Prediction of Coronary and Cardiovascular Deaths
Authors: Michael J. Blaha, Seamus P. Whelton, Mahmoud Al Rifai, Zeina Dardari, Leslee J. Shaw, Mouaz H. Al-Mallah, Kunihiro Matsushita, Alan Rozanski, John A. Rumberger, Daniel S. Berman, Matthew J. Budoff, Michael D. Miedema, Khurram Nasir, Miguel Cainzos-Achirica
Journal: JACC. Cardiovascular imaging (2020)
Nasal DNA methylation profiling of asthma and rhinitis
Authors: Cancan Qi, Yale Jiang, Ivana V. Yang, Erick Forno, Ting Wang, Judith M. Vonk, Ulrike Gehring, Henriëtte A. Smit, Edith B. Milanzi, Orestes A. Carpaij, Marijn Berg, Laura Hesse, Sharon Brouwer, Jonathan Cardwell, Cornelis J. Vermeulen, Edna Acosta-Pérez, Glorisa Canino, Nadia Boutaoui, Maarten van den Berge, Sarah A. Teichmann, Martijn C. Nawijn, Wei Chen, Juan C. Celedón, Cheng-Jian Xu, Gerard H. Koppelman
Journal: Journal of Allergy and Clinical Immunology (2020)
Updated Analysis of a Combination Herbal Supplement Trial in Biochemically Recurrent Prostate Cancer
Authors: J. Pinski, T.B. Dorff, D. Hawes, D. Tsao-Wei, D.I. Quinn, A. Goldkorn, G. Liskovsky, N. Vogelzang, S. Groshen, L. Ji
Journal: Annals of Oncology (2012)
Measles: Democratic Republic of the Congo recorded over 6000 deaths last year
Authors: Elisabeth Mahase
Journal: BMJ (2020)

More than 6000 people in the Democratic Republic of the Congo died in 2019 in what the World Health Organisation has called the world’s worst measles epidemic.1

WHO said that since the beginning of 2019 around 310 000 suspected cases have been reported in the country. This was despite the vaccination against measles of more than 18 million children under the age of 5 in the republic last year through joint efforts between the DRC Ministry of Health, WHO, Gavi (the Vaccine Alliance), and other partner aid agencies. However, in some areas …
Enhanced CaMKII-Dependent Late I <sub>Na</sub> Induces Atrial Proarrhythmic Activity in Patients With Sleep-Disordered Breathing
Authors: Simon Lebek, Konstantin Pichler, Kathrin Reuthner, Maximillian Trum, Maria Tafelmeier, Julian Mustroph, Daniele Camboni, Leopold Rupprecht, Christof Schmid, Lars S. Maier, Michael Arzt, Stefan Wagner
Journal: Circulation Research (2020)

Rationale: Sleep-disordered breathing (SDB) is frequently associated with atrial arrhythmias. Increased CaMKII (Ca/calmodulin-dependent protein kinase II) activity has been previously implicated in atrial arrhythmogenesis. Objective: We hypothesized that CaMKII-dependent dysregulation of Na current (I Na ) may contribute to atrial proarrhythmic activity in patients with SDB. Methods and Results: We prospectively enrolled 113 patients undergoing elective coronary artery bypass grafting for cross-sectional study and collected right atrial appendage biopsies. The presence of SDB (defined as apnea-hypopnea index ≥15/h) was assessed with a portable SDB monitor the night before surgery. Compared with 56 patients without SDB, patients with SDB (57) showed a significantly increased level of activated CaMKII. Patch clamp was used to measure I Na . There was a significantly enhanced late I Na , but reduced peak I Na due to enhanced steady-state inactivation in atrial myocytes of patients with SDB consistent with significantly increased CaMKII-dependent cardiac Na channel phosphorylation (Na V 1.5, at serine 571, Western blotting). These gating changes could be fully reversed by acute CaMKII inhibition (AIP [autocamtide-2 related inhibitory peptide]). As a consequence, we observed significantly more cellular afterdepolarizations and more severe premature atrial contractions in atrial trabeculae of patients with SDB, which could be blocked by either AIP or KN93 (N-[2-[[[(E)-3-(4-chlorophenyl)prop-2-enyl]-methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide). In multivariable linear regression models incorporating age, sex, body mass index, existing atrial fibrillation, existing heart failure, diabetes mellitus, and creatinine levels, apnea-hypopnea index was independently associated with increased CaMKII activity, enhanced late I Na and correlated with premature atrial contraction severity. Conclusions: In atrial myocardium of patients with SDB, increased CaMKII-dependent phosphorylation of Na V 1.5 results in dysregulation of I Na with proarrhythmic activity that was independent from preexisting comorbidities. Inhibition of CaMKII may be useful for prevention or treatment of arrhythmias in SDB. Clinical Trial Registration: URL: http://www.clinicaltrials.gov . Unique identifier: NCT02877745. Visual Overview: An online visual overview is available for this article.
Exome sequencing in schizophrenia-affected parent–offspring trios reveals risk conferred by protein-coding de novo mutations
Authors: Daniel P. Howrigan, Samuel A. Rose, Kaitlin E. Samocha, Menachem Fromer, Felecia Cerrato, Wei J. Chen, Claire Churchhouse, Kimberly Chambert, Sharon D. Chandler, Mark J. Daly, Ashley Dumont, Giulio Genovese, Hai-Gwo Hwu, Nan Laird, Jack A. Kosmicki, Jennifer L. Moran, Cheryl Roe, Tarjinder Singh, Shi-Heng Wang, Stephen V. Faraone, Stephen J. Glatt, Steven A. McCarroll, Ming Tsuang, Benjamin M. Neale
Journal: Nature Neuroscience (2020)
Abstract 294: Different Effect of Bystander CPR According to Dispatcher-Assistance on Neurologic Outcome in Out-Of-Hospital Cardiac Arrest
Authors: Jieun Pak, Tae Han Kim, Min Woo Kim, Jong Hwan Kim, Ki Jeong Hong, Sang Do Shin
Journal: Circulation (2019)

Introduction: Bystander CPR is an important prognostic factor for outcome in out-of-hospital cardiac arrest (OHCA). Dispatcher-assisted(DA) CPR program have shown to successfully increase rate of bystander CPR in communities. However DA-CPR is usually targeted for bystanders with no or lower level of CPR training compared to bystanders who are able to perform CPR without dispatcher assistance. We evaluated the effect of bystander CPR separately according to presence of dispatcher assistance on neurologic outcome. Methods: Retrospective analysis was performed using nationwide OHCA database from 2014 to 2017. Adult EMS treated OHCA with presumed cardiac origin were enrolled. EMS witnessed arrest and arrest occurred during ambulance transport were excluded. Bystander CPR was classified into 2 groups according to presence of DA-CPR instruction from emergency medical dispatch center. Rate of favorable neurologic outcome (CPC 1 or 2) was compared according to type of bystander CPR. Multivariable logistic regression model was used to estimate effect of bystander CPR type on outcomes. Results: Total of 72,314 eligible OHCA were enrolled for final analysis. Proportion of patients with favorable neurologic outcome was highest in bystander CPR without dispatcher assistance. (8.6% for bystander CPR without DA, 5.0% for bystander CPR with DA and 2.9% for no bystander CPR, p&lt;0.01). Bystander CPR with DA was associated with higher chance of good neurological recovery than no bystander CPR, effect on neurologic outcome was significantly different than bystander CPR without DA(adjusted OR with 95% CI (bystander CPR with DA as reference): 0.61[0.55-0.67] for no-bystander CPR , 1.24[1.14–1.36] for bystander CPR without DA) Conclusion: Bystander CPR with DA showed positive effect on neurologic outcome compared to no-bystander CPR. However bystander CPR with DA was less effective than bystander CPR performed without dispatcher assistance. To improve quality of bystander CPR with dispatcher assistance, strategy to monitor and give feedback bystander CPR during dispatcher assistance should be developed and implemented in dispatch center.
Food Effect Study of the Investigational Aurora a Kinase (AAK) Inhibitor MLN8237 (ALISERTIB) in Patients with Advanced Solid Tumors
Authors: G.S. Falchook, X. Zhou, L.S. Rosen, K. Venkatakrishnan, R. Kurzrock, D. Mahalingam, J. Goldman, J. Jung, C. Milch, J. Sarantopoulos
Journal: Annals of Oncology (2012)
ASCO updated recommendations for preventing and treating VTE in adults with cancer
Authors: Martin R. Stockler
Journal: Annals of Internal Medicine (2020)

Source Citation Key NS, Khorana AA, Kuderer NM, et al. Venous thromboembolism prophylaxis and treatment in patients with cancer: ASCO clinical practice guideline update. J Clin Oncol. 2019. [Epub ahead of print]. 31381464
Incidence and Outcomes Associated With<i>Clostridium difficile</i>Infections
Authors: Alexandre R. Marra, Eli N. Perencevich, Richard E. Nelson, Matthew Samore, Karim Khader, Hsiu-Yin Chiang, Margaret L. Chorazy, Loreen A. Herwaldt, Daniel J. Diekema, Michelle F. Kuxhausen, Amy Blevins, Melissa A. Ward, Jennifer S. McDanel, Rajeshwari Nair, Erin Balkenende, Marin L. Schweizer
Journal: JAMA Network Open (2020)

<h3>Importance</h3> An understanding of the incidence and outcomes of<i>Clostridium difficile</i>infection (CDI) in the United States can inform investments in prevention and treatment interventions. <h3>Objective</h3> To quantify the incidence of CDI and its associated hospital length of stay (LOS) in the United States using a systematic literature review and meta-analysis. <h3>Data Sources</h3> MEDLINE via Ovid, Cochrane Library Databases via Wiley, Cumulative Index of Nursing and Allied Health Complete via EBSCO Information Services, Scopus, and Web of Science were searched for studies published in the United States between 2000 and 2019 that evaluated CDI and its associated LOS. <h3>Study Selection</h3> Incidence data were collected only from multicenter studies that had at least 5 sites. The LOS studies were included only if they assessed postinfection LOS or used methods accounting for time to infection using a multistate model or compared propensity score–matched patients with CDI with control patients without CDI. Long-term-care facility studies were excluded. Of the 119 full-text articles, 86 studies (72.3%) met the selection criteria. <h3>Data Extraction and Synthesis</h3> Two independent reviewers performed the data abstraction and quality assessment. Incidence data were pooled only when the denominators used the same units (eg, patient-days). These data were pooled by summing the number of hospital-onset CDI incident cases and the denominators across studies. Random-effects models were used to obtain pooled mean differences. Heterogeneity was assessed using the<i>I</i><sup>2</sup>value. Data analysis was performed in February 2019. <h3>Main Outcomes and Measures</h3> Incidence of CDI and CDI-associated hospital LOS in the United States. <h3>Results</h3> When the 13 studies that evaluated incidence data in patient-days due to hospital-onset CDI were pooled, the CDI incidence rate was 8.3 cases per 10 000 patient-days. Among propensity score–matched studies (16 of 20 studies), the CDI-associated mean difference in LOS (in days) between patients with and without CDI varied from 3.0 days (95% CI, 1.44-4.63 days) to 21.6 days (95% CI, 19.29-23.90 days). <h3>Conclusions and Relevance</h3> Pooled estimates from currently available literature suggest that CDI is associated with a large burden on the health care system. However, these estimates should be interpreted with caution because higher-quality studies should be completed to guide future evaluations of CDI prevention and treatment interventions.
Aprepitant is Active in the Management of Biological Therapies-Related Severe Pruritus: a Phase-II Study
Authors: D. Santini, F.M. Guida, G. Schiavon, O. Venditti, A.M. Frezza, M. Imperatori, C. Spoto, P. Berti, B. Vincenzi, G. Tonini
Journal: Annals of Oncology (2012)
A Cytokine and Angiogenic Factor (CAF) Analysis in Plasma in Testicular Germ Cell Tumor Patients
Authors: M. Mego, D. Cholujova, P. Gronesova, M. Pastorek, V. Miskovska', J. Obertova, V. Usakova, D. Ondrus, S. Spanik, J. Mardiak
Journal: Annals of Oncology (2012)
Moving cancer immunotherapy forward through the<i>Journal for ImmunoTherapy of Cancer (JITC</i>)
Authors: Pedro Romero
Journal: Journal for ImmunoTherapy of Cancer (2019)

Throughout the 6 years of the Journal for ImmunoTherapy of Cancer 's ( JITC ) existence, the field of cancer immunotherapy has changed dramatically. In 2013, when the journal was founded, no programmed death (PD)-1 inhibitors had yet been approved by the Food and Drug Administration (FDA); the
P1.23 Quantitative Detection of Discriminatory Proteins in Tissue and Serum of Ovarian Cancer Patients by Lc-Mse
Authors: W. Wegdam, D. Meijer, G. Kramer, J. Langridge, P.D. Moerland, S.M. de Jong, J.P. Vissers, G.G. Kenter, M.R. Buist, J.M.F.G. Aerts
Journal: Annals of Oncology (2012)
Abstract 236: Complete Recoil Duration Declines Over the Course of Longer Resuscitations
Authors: James K Russell, Amber Lin, Digna M Gonzalez-Otero, Mikel Leturiondo, Jesus M Ruiz, Mohamud R Daya, Sofia Ruiz de Gauna
Journal: Circulation (2019)

Introduction: CPR guidelines call for chest compressions within rate and depth ranges and complete chest recoil. Guidelines development has relied on data from the first 10 minutes of resuscitations. We investigated the influence of rate, depth and chest stiffness on complete recoil duration in longer resuscitations. Hypothesis: Decreasing chest stiffness will contribute to reduced complete recoil duration over the course of long resuscitations. Methods: Acceleration and force signals were from monitors used in continuous compression CPR during out-of-hospital resuscitations of adults treated by Tualatin Valley Fire &amp; Rescue (Tigard, OR) from 2013 through 2017. Complete recoil was defined as return to within 5 mm of baseline in the absence of leaning (release force &gt; 2.5 kg-f), stiffness as peak force/peak depth. Influences of rate, depth and stiffness on complete recoil duration were modeled with linear mixed effects models with a random intercept and slope clustered by patient. Results: A total of 1,076,808 compressions without leaning (93% of compressions) were measured from 616 cases with 1888 ± 1118 compressions/case (mean ± std). Observed increases in rate (7%) and depth (2%) were modest, while stiffness declined markedly (-33%) (Fig 1a). All of these changes tend to reduce the duration of complete recoil (p &lt; 0.001). Mean complete recoil duration decreased 21% (Fig 1a) from 160 ms to 126 ms (Fig 1b). Despite its large relative change, stiffness had little effect on complete recoil duration, as did depth. Increasing rate explained most of the decline in complete recoil duration (Fig 1b). Conclusions: Substantial decline in chest stiffness over the course of long resuscitations contributes to reduction of complete recoil duration but little compared to increasing rate. Careful compliance with rate guidelines is paramount in maintaining periods of complete recoil. Depth is relatively well-controlled. Chest molding (decreased stiffness) is of secondary importance.
Feasibility on Short Hydration Regimen of Intermediate- to High-Dose Cisplatin-Based Chemotherapy for Outpatient Treatment
Authors: E. Sakaida, H. Ashinuma, S. Kitazono, M. Kitazono, A. Kitamura, Y. Ohoka, T. Uehara, T. Oku, C. Imai, H. Saeki, H. Nakasa, M. Kitada, I. Sekine, Y. Takiguchi
Journal: Annals of Oncology (2012)
Hepatitis B Virus Particles Activate Toll‐Like Receptor 2 Signaling Initially Upon Infection of Primary Human Hepatocytes
Authors: Zhenhua Zhang, Martin Trippler, Catherine I. Real, Melanie Werner, Xufeng Luo, Stefan Schefczyk, Thekla Kemper, Olympia E. Anastasiou, Yvonne Ladiges, Juergen Treckmann, Andreas Paul, Hideo A. Baba, Lena Allweiss, Maura Dandri, Guido Gerken, Heiner Wedemeyer, Joerg F. Schlaak, Mengji Lu, Ruth Broering
Journal: Hepatology (2020)

BACKGROUND AND AIMS To date, conflicting data exist as to whether hepatitis B virus (HBV) has the ability to induce innate immune responses. Here, we investigated cellular changes after the first contact between HBV and primary human hepatocytes (PHH) in vitro and in vivo . APPROACH AND RESULTS The exposure of PHH to HBV particles resulted in nuclear translocation of NFκB, followed by the expression and secretion of inflammatory cytokines (IL [interleukin] 1B, IL6, and TNF [tumor necrosis factor]). Ultraviolet irradiation of viral particles suppressed HBV infectivity but not the induction of cytokines in PHH, suggesting that the inoculum contains the immune‐inducing agent. Purified HBV particles on the whole, which were prepared from HBV DNA‐positive and protein‐rich fractions after heparin column separation, still had immune‐inducing capacity in PHH. The HBV‐induced gene expression profile was similar to that induced by toll‐like receptor 2 (TLR2) ligand Pam3Cys, but different from those induced by the viral sensors TLR3 or TLR7‐9. Treatment of PHH with both HBV particles and Pam3Cys led to phosphorylation of ERK (extracellular signal–regulated kinase), JNK, and p38 mitogen‐activated protein kinases as well as NFκB (nuclear factor kappa B). Finally, HBV‐induced gene expression could be neutralized by TLR2‐specific antibodies. Of note, pretreatment with an HBV entry inhibitor attenuated the TLR2‐mediated response to HBV, suggesting a receptor binding‐related mechanism. In liver‐humanized uPA/severe combined immunodeficient (SCID)/beige mice challenged with HBV in vivo , immune induction could only marginally be seen. CONCLUSIONS PHHs are able to sense HBV particles through TLR2, leading to an activation of anti‐HBV immune responses in vitro . These findings challenge the previously described stealth properties of HBV.
Extracorporeal Photopheresis for Colitis Induced by Checkpoint-Inhibitor Therapy
Authors: Petya Apostolova, Susanne Unger, Dagmar von Bubnoff, Frank Meiss, Burkhard Becher, Robert Zeiser
Journal: New England Journal of Medicine (2020)

Extracorporeal Photopheresis for Autoimmune Colitis Extracorporeal photopheresis has been an effective treatment for graft-versus-host disease. In this case, it was used to treat a patient with sev...
Is Postmastectomy Radiotherapy for Patients Diagnosed With Breast Cancer who Have Received Neoadjuvant Therapy Really Necessary?
Authors: R.M. Rodríguez, M.T. Cano Osuna, G. Pulido, I. Porras, P. Sánchez, A. Moreno, J. Jiménez, M.J. Ortiz-Morales, E. Aranda Aguilar, J. La De Haba
Journal: Annals of Oncology (2012)
Privacy Risks of Sharing Data from Environmental Health Studies
Authors: Katherine E. Boronow, Laura J. Perovich, Latanya Sweeney, Ji Su Yoo, Ruthann A. Rudel, Phil Brown, Julia Green Brody
Journal: Environmental Health Perspectives (2020)

Background: Sharing research data uses resources effectively; enables large, diverse data sets; and supports rigor and reproducibility. However, sharing such data increases privacy risks for participants who may be re-identified by linking study data to outside data sets. These risks have been investigated for genetic and medical records but rarely for environmental data. Objectives: We evaluated how data in environmental health (EH) studies may be vulnerable to linkage and we investigated, in a case study, whether environmental measurements could contribute to inferring latent categories (e.g., geographic location), which increases privacy risks. Methods: We identified 12 prominent EH studies, reviewed the data types collected, and evaluated the availability of outside data sets that overlap with study data. With data from the Household Exposure Study in California and Massachusetts and the Green Housing Study in Boston, Massachusetts, and Cincinnati, Ohio, we used k-means clustering and principal component analysis to investigate whether participants' region of residence could be inferred from measurements of chemicals in household air and dust. Results: All 12 studies included at least two of five data types that overlap with outside data sets: geographic location (9 studies), medical data (9 studies), occupation (10 studies), housing characteristics (10 studies), and genetic data (7 studies). In our cluster analysis, participants' region of residence could be inferred with 80%–98% accuracy using environmental measurements with original laboratory reporting limits. Discussion: EH studies frequently include data that are vulnerable to linkage with voter lists, tax and real estate data, professional licensing lists, and ancestry websites, and exposure measurements may be used to identify subgroup membership, increasing likelihood of linkage. Thus, unsupervised sharing of EH research data potentially raises substantial privacy risks. Empirical research can help characterize risks and evaluate technical solutions. Our findings reinforce the need for legal and policy protections to shield participants from potential harms of re-identification from data sharing. https://doi.org/10.1289/EHP4817
ZEB1 and ZEB2 Mediate Pancreatic Fibroblast Induced Epithelial-To Mesenchymal Transition (EMT) in Pancreatic Cancer
Authors: L. Visa, E. Samper, M. Rickmann, A. Postigo, E. Sanchez-Tilo, L. Fernandez-Cruz, J. Maurel, X. Molero, E.C. Vaquero
Journal: Annals of Oncology (2012)
セフタジジム-アビバクタム: 新規セファロスポリン/β-ラクタマーゼ阻害剤の併用
Authors: G Zhanel George, D Lawson Christopher, Adam Heather, Schweizer Frank, Zelenitsky Sheryl, R S Lagace-Wiens Philippe, Denisuik Andrew, Rubinstein Ethan, S Gin Alfred, J Hoban Daryl, Lynch Joseph P. rd, A Karlowsky James
Journal: Drugs (2013)
TRIP8bスプライス変異体は,脳において、HCNチャンネルのゲート開閉および輸送を制御する一群の補助サブユニットを形成する
Authors: Santoro Bina, A Piskorowski Rebecca, Pian Phillip, Hu Lei, Liu Haiying, A Siegelbaum Steven
Journal: Neuron (2009)
Absence of Liver Metastasis, LYMPH Node Metastasis and Peritoneal Metastasis Predict Longer Progression Free Survival by S-1 Plus Cisplatin Treatment in Advanced Gastric Cancer
Authors: D. Inoue, K. Chin, K. Ohara, Kouichi Takagi, Masato Ozaka, Mariko Ogura, Mitsukuni Suenaga, Eiji Shinozaki, Satoshi Matsusaka, Nobuyuki Mizunuma, Kiyohiko Hatake
Journal: Annals of Oncology (2012)