AB0230 An effect of dasd28 and ps-vas on haq-di score in rheumatoid arthritis patient
Authors: I. Yoshii
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Pain Score with visual analogue scale (PS-VAS) influences on Health Assessment Questionnaire Disease Index (HAQ-DI) in rheumatoid arthritis (RA) patient, as well as 28-joints disease activity score with C-reactive protein (DAS28-CRP). It is also suggested that these two indices have closely correlated and therefore have overlapping effect on HAQ-DI. However, the relationship of these indices for each other is still unclear. <h3>Objectives</h3> Our aim is to clarify what affects most out of the overlap, and what would make influence on when dissociation between the two occurs. <h3>Methods</h3> We have treated 549 RA patients consecutively more than four years. Their HAQ-DI, every component of DAS28-CRP, physician's global assessment (EGA), PS-VAS, and Sharp/van der Heijde Score (SHS) were monitored every 3 months. From these patients studies concerning relationship between the parameters were investigated as follows;<sup>1</sup> The relationship between average DAS28-CRP and average PS-VAS after the third year period was calculated using multivariate linear regression analysis (MLR).<sup>2</sup> Then residuals of the each parameter from the approximate equation of MLR were calculated. From these residuals, correlation between residual of DAS28-CRP and disease duration (DD), HAQ-DI, age, SHS, physician's global assessment (EGA), number of comorbidities in throughout treatment (Com) was evaluated with MLR.<sup>3</sup> Correlation between residual of PS-VAS and DD, HAQ-DI, age, SHS, EGA, and Com was evaluated with MLR.<sup>4</sup> Correlation between average HAQ-DI and the residuals, patient's DD, age, SHS, EGA, and Com, was evaluated with MLR. In these analyses, statistical significance between parameters were evaluated statistically. Statistical significance was set lower than 1%. <h3>Results</h3> Because of lacking of data, sixty-one cases had discarded, and then 488 cases had been analysed in this study.<sup>1</sup> The approximate equation of the relation between DAS28-CRP and PS-VAS was "DAS28-CRP=1.543+0.1565 * PS-VAS" (R; 05050, Intercept; p=0, PS-VAS; p=0) and "PS-VAS=−0.6528+1.63 * DAS28-CRP" (R; 0.5050, Intercept; p=1.071*10–2, PS-VAS; p=0).<sup>2</sup> Correlation coefficients of the approximate equation of the correlation between residuals of DAS28-CRP and the other parameters was 0.6398. Parameters that demonstrated within 1% of statistical significance were EGA (p=0), SHS (p=2.962*10–6), and Com (p=1.971*10–5).<sup>3</sup> Correlation coefficients of the approximate equation of the correlation between residuals of PS-VAS and the other parameters was 0.4856. Parameters that demonstrated within 1% of statistical significance were Com (p=9.38*10–1<sup>1</sup>), HAQ-DI (p=5.738*10–9), and SHS (p=1.594*10–7).<sup>4</sup> Correlation coefficients of the approximate equation of the correlation between HAQ-DI and residuals of DAS28-CRP and PS-VAS, and DD, age, SHS, EGA, and Com, was 0.5848. Parameters that demonstrated within 1% of statistical significance were residual of DAS28-CRP (p=1.256*10–6), residual of PS-VAS (p=3.711*10–1<sup>4</sup>), SHS (p=7.73*10–4), and age (p=2.389*10–1<sup>0</sup>). <h3>Conclusions</h3> These results suggest that the influence of DAS28-CRP and PS-VAS on the HAQ-DI score works in commonly overlapped. However, residual (the independent part) of DAS28-CRP from PS-VAS on HAQ-DI is not statistically evident. Residual of PS-VAS affects on the HAQ-DI score. SHS and Com affect on both of residuals. The HAQ-DI score is influenced by both of common and independent part of DAS28-CRP and PS-VAS, and SHS and age. <h3>Disclosure of Interest</h3> None declared