AB0785 REAL LIFE EXPERIENCE OF METHOTREXATE BASED DUAL COMBINATION DMARDS IN PSORIATIC ARTHRITIS- RESULTS FROM KARNATAKA PSORIATIC ARTHRITIS COHORT (KPsAC)
Authors: U. Karjigi, C. Kodishala, S. Chandrashekara, S. Kumar, V. Haridas, S. R, R. Jois, M. Daware, V. K. R. Rao, B. G. Dharmanand, V. R. K. Jain, Y. P. Singh, S. Singhai, P. Chebbi, C. Dharmapalaiah, A. Kamath, S. Prasad, S. C, R. Aithala, B. Pinto, B. Nazir, H. Alur Shivakumar, M. K M, V. Shobha
Journal: Annals of the Rheumatic Diseases (2020)

Background: Biologics have been the focus of recent treatment guidelines and ‘Treat to Target’ strategies for both psoriasis (PsO) &amp; psoriatic Arthritis (PsA). However, in day-today practice, combination DMARDs anchored around methotrexate are mainstay in majority of patients. Objectives: To describe experience and effectiveness of Methotrexate in combination with conventional DMARDs in Karnataka Psoriatic Arthritis Cohort. Methods: Treatment information was extracted from KPsAC (n=549) which is a cross sectional, non-interventional study conducted across 17 rheumatology practicing centres in Karnataka, India using a structured proforma. This study was approved by respective Ethical committee. Information on efficacy was extracted for various csDMARDs in combination with methotrexate. Standard disease activity outcome measures were used for assessing the response to therapy (DAPSA, PASI, HAQ, MDA5). All participating rheumatologists underwent training to calculate PASI and other outcome scores. Results: Nearly half of the patients in our cohort were on methotrexate (44%) monotherapy. Proportion of patients who received combination csDMARD anchored on methotrexate were 29%. The choice of add on csDMARD was as per clinician discretion or subject preference. Patients were divided in to three groups based on treatments they were receiving at the time of study: Methotrexate (Mtx)+Leflunomide (Lef), Mtx+Sulfasalazine (SSz) and Mtx+Apremilast(Apr). Their characteristics along with outcome measures are depicted in table 1. In Mtx+Apr group: remission or low disease activity was present in 42%, HAQ score of &lt;0.5 was seen in 82%, and only one patient had a PASI of &gt; 10. PASI was significantly lower in the Mtx+Apr group compared to Mtx+Lef group (p&lt;0.009) and Mtx +Ssz group (p &lt; 0.020) Conclusion: Apremilast is an orally administered, small molecule inhibitor of phosphodiesterase 4 (PDE4)**. In this observational study, 3 groups of methotrexate plus csDMARD- leflunomide, sulphasalazine and apremilast fared similarly for articular domain of PsA. However, in cutaneous domain, PASI was significantly lower in apremilast + methotrexate group. To our knowledge, this is the first real life report of the use of combination DMARDs in unselected PsA patients demonstrating effectiveness of apremilast in cutaneous domain. Methotrexate remains anchor DMARD for treatment of PsA in 2/3 rd of PsA patients. Addition of apremilast to methotrexate inadequate responders appears to be beneficial in PsA with persistent cutaneous disease. However, being an observational study, this needs to be confirmed in controlled clinical trials. References: ** Apremilast: A Review in Psoriasis and Psoriatic Arthritis, Drugs March 2017, Volume 77, Issue 4. Table. Characteristics and comparison of combination csDMARDs MTX+SSZ (N=39 ) MTX+LEF (n=77 ) MTX+APR (N=45 ) Median Age (years) 37 39 35 Median disease duration (months) 96 101 112 Enthesitis (Ever) 6(15%) 21(27%) 4(8%) Dactylitis (Ever) 9((23%) 28(36%) 12 (26%) DAPSA &lt; 4 6(15%) 9(11%) 10(22%) 4-14 14(36%) 25(32%) 13(29%) 14-28 7(18%) 24(31%) 11(24%) PASI &gt;10 7(18%) # 14(18%) * 1(2%) *# HAQ &lt; 0.5 30(77%) 60(78%) 37(82%) MDA 5 achieved 16(41%) 25(32%) 19(42%) *P value &lt; 0.009 #P value &lt;0.02 Disclosure of Interests: None declared