tbuckley/cabot-search huggingface dataset:
Identification of Common Neural Circuit Disruptions in Emotional Processing Across Psychiatric Disorders
Authors: Lisa M. McTeague, Benjamin M. Rosenberg, James W. Lopez, David M. Carreon, Julia Huemer, Ying Jiang, Christina F. Chick, Simon B. Eickhoff, Amit Etkin
Journal: American Journal of Psychiatry (2020)

Objective: Disrupted emotional processing is a common feature of many psychiatric disorders. The authors investigated functional disruptions in neural circuitry underlying emotional processing across a range of tasks and across psychiatric disorders through a transdiagnostic quantitative meta-analysis of published neuroimaging data. Methods: A PubMed search was conducted for whole-brain functional neuroimaging findings published through May 2018 that compared activation during emotional processing tasks in patients with psychiatric disorders (including schizophrenia, bipolar or unipolar depression, anxiety, and substance use) to matched healthy control participants. Activation likelihood estimation (ALE) meta-analyses were conducted on peak voxel coordinates to identify spatial convergence. Results: The 298 experiments submitted to meta-analysis included 5,427 patients and 5,491 control participants. ALE across diagnoses and patterns of patient hyper- and hyporeactivity demonstrated abnormal activation in the amygdala, the hippocampal/parahippocampal gyri, the dorsomedial/pulvinar nuclei of the thalamus, and the fusiform gyri, as well as the medial and lateral dorsal and ventral prefrontal regions. ALE across disorders but considering directionality demonstrated patient hyperactivation in the amygdala and the hippocampal/parahippocampal gyri. Hypoactivation was found in the medial and lateral prefrontal regions, most pronounced during processing of unpleasant stimuli. More refined disorder-specific analyses suggested that these overall patterns were shared to varying degrees, with notable differences in patterns of hyper- and hypoactivation. Conclusions: These findings demonstrate a pattern of neurocircuit disruption across major psychiatric disorders in regions and networks key to adaptive emotional reactivity and regulation. More specifically, disruption corresponded prominently to the “salience” network, the ventral striatal/ventromedial prefrontal “reward” network, and the lateral orbitofrontal “nonreward” network. Consistent with the Research Domain Criteria initiative, these findings suggest that psychiatric illness may be productively formulated as dysfunction in transdiagnostic neurobehavioral phenotypes such as neurocircuit activation.
Considerations on equity in management of end-stage kidney disease in low- and middle-income countries
Authors: Wim Van Biesen, Vivekanand Jha, Ali K. Abu-Alfa, Sharon P. Andreoli, Gloria Ashuntantang, Bassam Bernieh, Edwina Brown, Yuqing Chen, Rosanna Coppo, Cecile Couchoud, Brett Cullis, Walter Douthat, Felicia U. Eke, Brenda Hemmelgarn, Fan Fan Hou, Nathan W. Levin, Valerie A. Luyckx, Rachael L. Morton, Mohammed Rafique Moosa, Fliss E.M. Murtagh, Marie Richards, Eric Rondeau, Daniel Schneditz, Kamal D. Shah, Vladimir Tesar, Karen Yeates, Guillermo Garcia Garcia
Journal: Kidney International Supplements (2020)
22P BCL2 Negative Breast Tumors but not Axillary Lymph Nodes Predict a Better Overall Survival in Patients Treated with Higher Doses of Epirubicin at a Median follow-up of 15.6 Years
Authors: I. Bozovic, E. de Azambuja, S. Loi, L. Ameye, M. Piccart
Journal: Annals of Oncology (2012)
Association of HLA-DRB1∗09:01 with tIgE levels among African-ancestry individuals with asthma
Authors: Nicolas Vince, Sophie Limou, Michelle Daya, Wataru Morii, Nicholas Rafaels, Estelle Geffard, Venceslas Douillard, Alexandre Walencik, Meher Preethi Boorgula, Sameer Chavan, Candelaria Vergara, Victor E. Ortega, James G. Wilson, Leslie A. Lange, Harold Watson, Dan L. Nicolae, Deborah A. Meyers, Nadia N. Hansel, Jean G. Ford, Mezbah U. Faruque, Eugene R. Bleecker, Monica Campbell, Terri H. Beaty, Ingo Ruczinski, Rasika A. Mathias, Margaret A. Taub, Carole Ober, Emiko Noguchi, Kathleen C. Barnes, Dara Torgerson, Pierre-Antoine Gourraud
Journal: Journal of Allergy and Clinical Immunology (2020)
Anterior versus posterior approach in peroral endoscopic myotomy (POEM): a systematic review and meta-analysis
Authors: Babu P. Mohan, Andrew Ofosu, Saurabh Chandan, Daryl Ramai, Shahab R. Khan, Suresh Ponnada, Douglas G. Adler
Journal: Endoscopy (2020)

Abstract Background Peroral endoscopic myotomy (POEM) is increasingly being used as the endoscopic treatment option for achalasia. Data are limited as to the comparative efficacy of anterior vs. posterior myotomy. Methods We searched multiple databases from inception to August 2019 to identify studies reporting on POEM. We selected studies that reported on the outcomes of POEM, along with information on myotomy approach. We performed a comparative analysis of clinical success, gastroesophageal reflux disease (GERD), and adverse events with anterior and posterior myotomy in POEM by meta-analysis. Results 1247 patients from 18 studies were analyzed: 623 patients (11 cohorts) were treated via anterior myotomy and 624 patients (12 cohorts) via posterior myotomy. The pooled rate for clinical success gave an odds ratio (OR) of 1.02 (95 % confidence interval [CI] 0.52 – 2.0; I 2 0; P = 0.9); for GERD by esophagogastroduodenoscopy (EGD) was OR 1.02 (95 %CI 0.62 – 1.68; I 2 0; P = 0.9), and for GERD by pH was OR 0.98 (95 %CI 0.59 – 1.63; I 2 34; P = 0.9). The individual pooled rates of clinical success at 12 months and &gt; 12 months, GERD (by symptoms, EGD, pH), and adverse events (mild, moderate, severe) were comparable. The pooled total procedure time with anterior myotomy was 82.7 minutes (95 %CI 69.0 – 96.4; I 2 98) and with posterior myotomy was 62.1 minutes (95 %CI 48.5 – 75.7; I 2 90). Conclusion Anterior and posterior myotomy in POEM seem comparable to each other in terms of clinical success, GERD, and adverse events. The total procedure time with posterior myotomy seems to be shorter than with anterior myotomy.
多発性骨髄腫におけるシルツキシマブ(抗IL-6)併用下または非併用下でのボルテゾミブ-メルファラン-プレドニゾンに関する第2相無作為化試験 | 文献情報 | J-GLOBAL 科学技術総合リンクセンター
Authors: San-Miguel Jesus, Blade Joan, Shpilberg Ofer, Grosicki Sebastian, Maloisel Frederic, Min Chang-Ki, Zarzuela Marta Polo, Robak Tadeusz, Prasad Sripada V. S. S, Goh Yeow Tee, Laubach Jacob, Spencer Andrew, Mateos Maria-Victoria, Palumbo Antonio, Puchalski Tom, Reddy Manjula, Uhlar Clarissa, Qin Xiang, Van De Velde Helgi, Xie Hong, Z Orlowski Robert
Journal: Blood (2014)
Single cell analysis of human lung development: knowing what mesenchymal cells are and what they may be
Authors: Jennifer M.S. Sucre, James Hagood
Journal: European Respiratory Journal (2020)

<b>Single cell sequencing has identified new mesenchymal lineage markers in early human development, allowing for the more precise identification and characterisation of mesenchymal subpopulations in lung development and disease</b>http://bit.ly/2NpX6UY
Red and Processed Meats and Health Risks: How Strong Is the Evidence?
Authors: Frank Qian, Matthew C. Riddle, Judith Wylie-Rosett, Frank B. Hu
Journal: Diabetes Care (2020)

Prevailing dietary guidelines have widely recommended diets relatively low in red and processed meats and high in minimally processed plant foods for the prevention of chronic diseases. However, an ad hoc research group called the Nutritional Recommendations (NutriRECS) consortium recently issued “new dietary guidelines” encouraging individuals to continue their current meat consumption habits due to “low certainty” of the evidence, difficulty of altering meat eaters’ habits and preferences, and the lack of need to consider environmental impacts of red meat consumption. These recommendations are not justified, in large part because of the flawed methodologies used to review and grade nutritional evidence. The evidence evaluation was largely based on the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) criteria, which are primarily designed to grade the strength of evidence for clinical interventions especially pharmacotherapy. However, the infeasibility for conducting large, long-term randomized clinical trials on most dietary, lifestyle, and environmental exposures makes the criteria inappropriate in these areas. A separate research group proposed a modified and validated system for rating the meta-evidence on nutritional studies (NutriGRADE) to address several limitations of the GRADE criteria. Applying NutriGRADE, the evidence on the positive association between red and processed meats and type 2 diabetes was rated to be of “high quality,” while the evidence on the association between red and processed meats and mortality was rated to be of “moderate quality.” Another important limitation is that inadequate attention was paid to what might be replacing red meat, be it plant-based proteins, refined carbohydrates, or other foods. In summary, the red/processed meat recommendations by NutriRECS suffer from important methodological limitations and involve misinterpretations of nutritional evidence. To improve human and planetary health, dietary guidelines should continue to emphasize dietary patterns low in red and processed meats and high in minimally processed plant foods such as fruits and vegetables, whole grains, nuts, and legumes.
Complications of Antenatal Corticosteroids in Infants Born by Early Term Scheduled Cesarean Section
Authors: Katharine Gupta, Rohit Rajagopal, Felicia King, David Simmons
Journal: Diabetes Care (2020)

To compare neonatal hypoglycemia and respiratory morbidity rates in pregnancies complicated by diabetes following early term scheduled cesarean section (ETSCS) with and without maternal corticosteroid administration.In a retrospective cohort study, women with any form of diabetes in pregnancy undergoing ETSCS were included. Primary outcomes were admission rates to the neonatal intensive care unit (NICU) for respiratory distress syndrome (RDS)/transient tachypnea of the newborn (TTN) and/or neonatal hypoglycemia.NICU admission rates for neonatal hypoglycemia were significantly higher (24.2% vs. 4.4%, P = 0.003) and RDS/TTN rates were nonsignificantly higher (15.2% vs. 7.2%, P = 0.209) following corticosteroid administration.Corticosteroids were not beneficial among women with any form of diabetes in pregnancy undergoing ETSCS and, indeed, may be harmful. In our hospital, we have ceased the use of corticosteroids for women under these circumstances.
Family Caregivers’ Experiences With Health Care Workers in the Care of Older Adults With Activity Limitations
Authors: Jennifer L. Wolff, Vicki A. Freedman, John F. Mulcahy, Judith D. Kasper
Journal: JAMA Network Open (2020)

<h3>Importance</h3> Family and unpaid caregivers often play an active role in managing the care of older adults with activity limitations. <h3>Objective</h3> To examine caregivers' experiences with older adults' health care workers. <h3>Design, Setting, and Participants</h3> This survey study constitutes a secondary analysis of a sample of 1916 family and unpaid caregivers to 1203 community-living older adults with activity limitations who participated in the 2017 National Health and Aging Trends Study. Data analysis was performed January to August 2019. <h3>Exposures</h3> Caregiver sociodemographic characteristics, caregiving intensity, and frequency speaking with or emailing older adults' health care workers. <h3>Main Outcomes and Measures</h3> Caregiver-reported experiences when interacting with older adults' health care workers in the prior year, including being listened to, being asked about understanding of treatments, and being asked about help needed in managing older adults' care. <h3>Results</h3> Caregivers (mean [SE] age, 59.4 [0.5] years; 63.7% women) assisting community-living older adults with activity limitations reported that they never (56.3%), sometimes or rarely (33.0%), or often (10.7%) spoke with or emailed older adults' health care workers in the prior year. Most caregivers who interacted with older adults' health care workers reported being always (70.6%) or usually (18.2%) listened to and always (54.4%) or usually (17.7%) being asked about their understanding of older adults' treatments. Fewer caregivers reported being always (21.3%) or usually (6.9%) asked whether they needed help managing older adults' care, and nearly one-half (45.0%) were never asked. Caregivers who interacted with older adults' health care workers often (vs sometimes or rarely) were more likely to report being always or usually listened to (94.8% vs 86.9%;<i>P</i> = .004), being asked about understanding treatments (80.1% vs 69.5%;<i>P</i> = .02), and being asked about needing help (40.8% vs 24.1%;<i>P</i> &lt; .001). No other exposures were consistently associated with caregiver experiences. Measures of caregiving intensity, including caring for an older adult with dementia, were not associated with being listened to or asked about understanding, but were associated with being asked about needed help. Although caregivers of persons with dementia were more likely than caregivers of persons without dementia to report always being asked about needed help (26.9% vs 19.0%), a high percentage in both groups were never asked (41.2% vs 46.5%) (<i>P</i> = .007). <h3>Conclusions and Relevance</h3> These findings reinforce the need for strategies to better support family and unpaid caregivers, who are the main source of assistance to older adults with physical and/or cognitive limitations.
Climate Change Puts Children at Risk
Authors: Bridget M. Kuehn
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of a deep-learning computer-aided detection system on adenoma detection during colonoscopy (CADe-DB trial): a double-blind randomised study
Authors: Pu Wang, Xiaogang Liu, Tyler M Berzin, Jeremy R Glissen Brown, Peixi Liu, Chao Zhou, Lei Lei, Liangping Li, Zhenzhen Guo, Shan Lei, Fei Xiong, Han Wang, Yan Song, Yan Pan, Guanyu Zhou
Journal: The Lancet. Gastroenterology & hepatology (2020)
Evolving Issues in Oxygen Therapy in Acute Care Medicine
Authors: Laveena Munshi, Niall D. Ferguson
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MPL mutations in essential thrombocythemia uncover a common path of activation with eltrombopag dependent on W491
Authors: Gabriel Levy, Serge Carillo, Benjamin Papoular, Bruno Cassinat, Jean-Marc Zini, Emilie Leroy, Leila N. Varghese, Ilyas Chachoua, Jean-Philippe Defour, Steven O. Smith, Stefan N. Constantinescu
Journal: Blood (2020)
B22 Development of a Novel Serum Marker for Detecting Small-Cell Lung Cancer by Targeting a Cell Adhesion Molecule 1 (CADM1)
Authors: T. Ito, T. Funaki, H. Iwanari, G. Tanaka, T. Nagase, T. Hamakubo, Y. Murakami
Journal: Journal of Thoracic Oncology (2020)
Life as a physician in obstetrics and gynaecology
Authors: Jacqui Wise
Journal: BMJ (2020)

A career in obstetrics and gynaecology is flexible, exciting, and fulfilling. There is a great variety of work within the specialty, with most doctors working in both obstetrics and gynaecology.

Many consultants have an interest in a particular area, such as fertility care or high risk obstetrics, and some work solely in a specific area of practice. The specialty combines medical and surgical activity and involves close cooperation with other specialties such as colorectal surgery, oncology, and urology.

Most hospitals have a team of consultants who are responsible for providing obstetric or gynaecological care. Clinical activities are diverse, depending on your area of specialisation. Emergencies may arise at any time, so 24 hour cover is always necessary.

In obstetrics, most women, although pregnant, are otherwise fit and healthy. However, some will have acute or …
Long-term efficacy and safety of ruxolitinib versus best available therapy in polycythaemia vera (RESPONSE): 5-year follow up of a phase 3 study
Authors: Jean-Jacques Kiladjian, Pierre Zachee, Masayuki Hino, Fabrizio Pane, Tamas Masszi, Claire N Harrison, Ruben Mesa, Carole B Miller, Francesco Passamonti, Simon Durrant, Martin Griesshammer, Keita Kirito, Carlos Besses, Beatriz Moiraghi, Elisa Rumi, Vittorio Rosti, Igor Wolfgang Blau, Nathalie Francillard, Tuochuan Dong, Monika Wroclawska, Alessandro M Vannucchi, Srdan Verstovsek
Journal: The Lancet Haematology (2020)
Anaphylaxis—a 2020 practice parameter update, systematic review, and Grading of Recommendations, Assessment, Development and Evaluation (GRADE) analysis
Authors: Marcus S. Shaker, Dana V. Wallace, David B.K. Golden, John Oppenheimer, Jonathan A. Bernstein, Ronna L. Campbell, Chitra Dinakar, Anne Ellis, Matthew Greenhawt, David A. Khan, David M. Lang, Eddy S. Lang, Jay A. Lieberman, Jay Portnoy, Matthew A. Rank, David R. Stukus, Julie Wang, Natalie Riblet, Aiyana M.P. Bobrownicki, Teresa Bontrager, Jarrod Dusin, Jennifer Foley, Becky Frederick, Eyitemi Fregene, Sage Hellerstedt, Ferdaus Hassan, Kori Hess, Caroline Horner, Kelly Huntington, Poojita Kasireddy, David Keeler, Bertha Kim, Phil Lieberman, Erin Lindhorst, Fiona McEnany, Jennifer Milbank, Helen Murphy, Oriana Pando, Ami K. Patel, Nicole Ratliff, Robert Rhodes, Kim Robertson, Hope Scott, Audrey Snell, Rhonda Sullivan, Varahi Trivedi, Azadeh Wickham, Marcus S. Shaker, Dana V. Wallace, Marcus S. Shaker, Dana V. Wallace, Jonathan A. Bernstein, Ronna L. Campbell, Chitra Dinakar, Anne Ellis, David B.K. Golden, Matthew Greenhawt, Jay A. Lieberman, Matthew A. Rank, David R. Stukus, Julie Wang, Marcus S. Shaker, Dana V. Wallace, David B.K. Golden, Jonathan A. Bernstein, Chitra Dinakar, Anne Ellis, Matthew Greenhawt, Caroline Horner, David A. Khan, Jay A. Lieberman, John Oppenheimer, Matthew A. Rank, Marcus S. Shaker, David R. Stukus, Julie Wang
Journal: Journal of Allergy and Clinical Immunology (2020)
Abstract 219: Supplement Oxygen Dependence of Dissociated Oxygen Metabolism From Carbon Dioxide and Oxidative Toxic Stress in Post-Cardiac Arrest
Authors: Yu Okuma, Koichiro Shinozaki, Mitsuaki Nishikimi, Kota Saeki, Tai Yin, Junhwan Kim, Lance B Becker
Journal: Circulation (2019)

Objective: We recently reported a dissociation of oxygen metabolism in post-cardiac arrest rodents, which was represented by an increase in oxygen consumption (VO 2 ) without a concomitant increase in carbon dioxide generation (VCO 2 ) resulting in a lowered respiratory quotient (RQ) outside of the normally cited range of 0.7-1.0. We hypothesize that high supplemental O 2 is associated with both increased dissociation of oxygen metabolism and oxidative toxic stress after cardiac arrest (CA). Methods: Rats were resuscitated from 10 minutes of asphyxial CA and stratified into 2 groups: those that inhaled 100% supplemental O 2 (CA-FIO2 1.0) and those that inhaled 30% supplemental O 2 (CA-FIO2 0.3). We prepared a sham surgery group for comparison (sham-FIO2 0.3). Our newly developed method enabled measurements of VO 2 and VCO 2 from low to high inspiratory supplemental O 2 levels. RQ was calculated as VCO 2 /VO 2 . After 2 hours, we collected urine and tissue samples to determine the degree of reactive oxygen species (ROS) generation. Results: CA increased VO 2 (28.5±8.1 mL/kg/min at FIO2 1.0 and 19.1±3.0 at FIO2 0.3, p&lt;0.05) compared with the sham group (15.0±1.4), whereas no differences in VCO 2 were found among the three groups. RQ of CA-FIO2 1.0 animals persistently decreased to 0.57±0.03 (0.84 ±0.10 at CA-FIO2 0.3 and 0.96±0.14 at sham-FIO2 0.3). Regarding ROS generation, urinary 8-hydroxydeoxyguanosine (8-OHdG) and brain carbonyl protein of CA-FIO2 1.0 animals was significantly higher than the CA-FIO2 0.3 or sham groups. Conclusions: 100% supplemental oxygen increased VO 2 but not VCO 2 . 8-OHdG is produced during the repair of cellular DNA damaged from oxidative toxic stress and excreted into the urine. Our findings suggest that the high supplemental oxygen aggravate both dissociation of oxygen metabolism and oxidative toxic stress in post-CA rodents.
Looking Back to Improve Access to Health Care Moving Forward
Authors: John Z. Ayanian
Journal: JAMA Internal Medicine (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal