tbuckley/cabot-search huggingface dataset:
Blood Leukocyte DNA Methylation Predicts Risk of Future Myocardial Infarction and Coronary Heart Disease
Authors: Golareh Agha, Michael M. Mendelson, Cavin K. Ward-Caviness, Roby Joehanes, TianXiao Huan, Rahul Gondalia, Elias Salfati, Jennifer A. Brody, Giovanni Fiorito, Jan Bressler, Brian H. Chen, Symen Ligthart, Simonetta Guarrera, Elena Colicino, Allan C. Just, Simone Wahl, Christian Gieger, Amy R. Vandiver, Toshiko Tanaka, Dena G. Hernandez, Luke C. Pilling, Andrew B. Singleton, Carlotta Sacerdote, Vittorio Krogh, Salvatore Panico, Rosario Tumino, Yun Li, Guosheng Zhang, James D. Stewart, James S. Floyd, Kerri L. Wiggins, Jerome I. Rotter, Michael Multhaup, Kelly Bakulski, Steven Horvath, Philip S. Tsao, Devin M. Absher, Pantel Vokonas, Joel Hirschhorn, M. Daniele Fallin, Chunyu Liu, Stefania Bandinelli, Eric Boerwinkle, Abbas Dehghan, Joel D. Schwartz, Bruce M. Psaty, Andrew P. Feinberg, Lifang Hou, Luigi Ferrucci, Nona Sotoodehnia, Giuseppe Matullo, Annette Peters, Myriam Fornage, Themistocles L. Assimes, Eric A. Whitsel, Daniel Levy, Andrea A. Baccarelli
Journal: Circulation (2019)

Background: DNA methylation is implicated in coronary heart disease (CHD), but current evidence is based on small, cross-sectional studies. We examined blood DNA methylation in relation to incident CHD across multiple prospective cohorts. Methods: Nine population-based cohorts from the United States and Europe profiled epigenome-wide blood leukocyte DNA methylation using the Illumina Infinium 450k microarray, and prospectively ascertained CHD events including coronary insufficiency/unstable angina, recognized myocardial infarction, coronary revascularization, and coronary death. Cohorts conducted race-specific analyses adjusted for age, sex, smoking, education, body mass index, blood cell type proportions, and technical variables. We conducted fixed-effect meta-analyses across cohorts. Results: Among 11 461 individuals (mean age 64 years, 67% women, 35% African American) free of CHD at baseline, 1895 developed CHD during a mean follow-up of 11.2 years. Methylation levels at 52 CpG (cytosine-phosphate-guanine) sites were associated with incident CHD or myocardial infarction (false discovery rate&lt;0.05). These CpGs map to genes with key roles in calcium regulation (ATP2B2, CASR, GUCA1B, HPCAL1), and genes identified in genome- and epigenome-wide studies of serum calcium (CASR), serum calcium-related risk of CHD (CASR), coronary artery calcified plaque (PTPRN2), and kidney function (CDH23, HPCAL1), among others. Mendelian randomization analyses supported a causal effect of DNA methylation on incident CHD; these CpGs map to active regulatory regions proximal to long non-coding RNA transcripts. Conclusion: Methylation of blood-derived DNA is associated with risk of future CHD across diverse populations and may serve as an informative tool for gaining further insight on the development of CHD.
Bronchoscopy and Esophagoscopy. A Manual of Peroral Endoscopy and Laryngeal Surgery.
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum: Lymphatic microvessels in the rat remnant kidney model of renal fibrosis: Aminopeptidase p and podoplanin are discriminatory markers for endothelial cells of blood and lymphatic vessels. (Journal of the American Society of Nephrology (2003) 14 (1981-1989))
Authors: K Matsui, K Nagy-Bojarsky, P Laakkonen, S Krieger, K Mechtler, S Uchida, S Geleff, D H Kang, R J Johnson, D Kerjaschki
Journal: Journal of the American Society of Nephrology (2019)
Analysis of fatigue in non-small cell lung cancer patients treated with second-line pemetrexed.
Authors: Li Li, Katherine B. Winfree, Eduardo J. Pennella, Allicia C Girvan, Gerhardt Pohl, Coleman K. Obasaju
Journal: Journal of Clinical Oncology (2013)

e20629 Background: Cancer-related fatigue can be attributed to both treatment (tx) and the disease. Fatigue is a common adverse event (AE) of cancer tx and can profoundly affect patient (pt) well-being. It is unclear how often fatigue is a reason for dose adjustment, treatment delays, and discontinuations. Methods: To assess fatigue in pemetrexed (pem)-treated pts, we conducted post-hoc analyses of a prospective observational study of non–small cell lung cancer (NSCLC). Pts who received ≥ 1 dose of pem in routine 2nd-line medical care settings (N=434) were included in the analysis.Pt-reported fatigue scores were obtained from the MD Anderson Symptom Inventory-Lung Cancer (0 - not present to 10 - as bad as you can imagine) at the beginning of cycles (C) 1, 2, 4, 6 and at tx end. Physician (phys)-reported scores were obtained from AE assessments (grades 1-4) at C 2, 4, 6 and at tx end. Associations between pt-/phys-reported fatigue and dose reduction/treatment delays were explored using chi-square/exact tests at each cycle. Logistic regression explored the association between severe fatigue occurrence and possible confounders (α=0.05). Results: The table shows phys-reported fatigue incidence (%). Overall, 94% of pts reported some fatigue across all assessed cycles with 83% of pts reporting fatigue at baseline; 47% of pts reported severe fatigue (score ≥7) overall with 29% reporting severe fatigue at baseline. A significant association between severe phys-reported fatigue and treatment delay was observed only at C2 (p=0.02). After adjusting for possible confounders, low income and age ≤70 years were associated with severe pt-reported fatigue. ECOG PS ≥1, stage IV disease, and historical fatigue were associated with severe phys-reported fatigue. General pt- and phys-reported fatigue did not differ among racial groups. Conclusions: While pts and phys reported similar amounts of fatigue in general, pt-reported incidence of severe fatigue was higher. Factors related to severe fatigue differed between pts and phys. Fatigue had little influence on tx adjustments. [Table: see text]
Using a Novel Ontology to Improve Case-Finding of Primary Biliary Cholangitis (PBC) in the Patient Database of the Royal College of General Practitioners (RCGP) of the United Kingdom (UK)- Implications for Early Diagnosis and Management.
Authors: M Pericleous, C Kelly, C McGee, J Sherlock, I Yonova, R Byford, F Ferreira, S De Lusignan, A Ala
Journal: Hepatology (2018)
Review: After stroke or TIA, adding clopidogrel to aspirin for ≤ 1 month reduces recurrence and MACE
Authors: Graeme J. Hankey
Journal: Annals of Internal Medicine (2019)

ACP Journal Club20 August 2019Review: After stroke or TIA, adding clopidogrel to aspirin for ≤ 1 month reduces recurrence and MACEGraeme J. Hankey, MD, FRACPGraeme J. Hankey, MD, FRACPThe University of Western Australia, Perth, Western Australia, Australia (G.J.H.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJ201908200-014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationRahman H, Khan SU, Nasir F, et al. Optimal duration of aspirin plus clopidogrel after ischemic stroke or transient ischemic attack. Stroke. 2019;50:947-53. https://pubmed.ncbi.nlm.nih.gov/30852971Clinical Impact RatingsGIM/FP/GP: Hospitalists: Neurology: References1 Sandercock PA, Counsell C, Tseng MC, Cecconi E. Oral antiplatelet therapy for acute ischaemic stroke. Cochrane Database Syst Rev. 2014;3:CD000029. [PMID: 24668137] Google Scholar2 Johnston SC, Amarenco P, Albers GW, et al; SOCRATES Steering Committee and Investigators. Ticagrelor versus aspirin in acute stroke or transient ischemic attack. N Engl J Med. 2016;375:35-43. [PMID: 27160892] Google Scholar3 Yang Y, Zhou M, Zhong X, et al. Dual versus mono antiplatelet therapy for acute non-cardioembolic ischaemic stroke or transient ischaemic attack: a systematic review and meta-analysis. Stroke Vasc Neurol. 2018;3:107-16. [PMID: 30022798] Google Scholar4 Bath PM, Woodhouse LJ, Appleton JP, et al. Triple versus guideline antiplatelet therapy to prevent recurrence after acute ischaemic stroke or transient ischaemic attack: the TARDIS RCT. Health Technol Assess. 2018;22:1-76. [PMID: 30179153] Google Scholar5 Hao Q, Tampi M, O’Donnell M, et al. Clopidogrel plus aspirin versus aspirin alone for acute minor ischaemic stroke or high risk transient ischaemic attack: systematic review and meta-analysis. BMJ. 2018;363:k5108. [PMID: 30563866] Google Scholar Author, Article, and Disclosure InformationAffiliations: The University of Western Australia, Perth, Western Australia, Australia (G.J.H.)This article was published at Annals.org on 6 August 2019. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byExosomes Derived from CXCR4-Overexpressing BMSC Promoted Activation of Microvascular Endothelial Cells in Cerebral Ischemia/Reperfusion Injury 20 August 2019Volume 171, Issue 4Page: JC14KeywordsAspirinHemorrhageIschemic strokeMortalityMyocardial infarctionRisk ratioSafetyStrokeTransient ischemic attacks ePublished: 20 August 2019 Issue Published: 20 August 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
SAT0070 Knee osteoarthritis (koa) and varicose veins (vv): a case-control study of 600 patients
Authors: B Mazieres, S Andrieu, C Subreville, B Jamard, A Constantin, M Laroche, A Cantagrel
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> KOA and VV are two frequent diseases increasing with age, especially in women. Age, sex, BMI, standing position and heavy works are risk factors of both KOA and VV. The association of the two diseases is variously assessed in the literature: prevalence of VV in KOA patients varies from 18 to 64% and prevalence of KOA in VV patients varies from 12 to 68%. This association is still questionable, as no case-controlled study is available. <h3>Objectives</h3> To evaluate the possible association of the two diseases in a case-control study. <h3>Methods</h3> Three hundred patients with KOA defined according to the ACR criteria (mean age ± SD: 66 years ± 10, 64% women) were age and sex-matched with 300 controls (subjects without any present or past knee pain + normal examination of their knees + normal AP x-rays of their knees on standing extended position: Kellgren-Lawrence stage 0). All classical risk factors were recorded (sports, trauma, heredity, works, meniscectomy, ?). In this epidemiological survey, VV were classified as followed: no VV (V0), simple venous varicosities with dull ache or pressure sensation in the legs which feel heavy after prolonged standing, (V1), or VV with complications (erythema, dermatitis, hyperpigmentation developed along the distal aspect of the leg, or skin ulcers) or which were operated (V2). This grading system was set up assuming that the diagnosis of VV at stage 1 is sometimes questionable, while VV at stage 2 is more accurate. <h3>Results</h3> There were 95 and 74 V1 patients and 59 and 43 V2 patients in KOA and control groups respectively (Chi2 = 9.28; p = 0.0097). This increase of VV in KOA is also significant in women (chi2 = 9.498; p = 0.0087), but not in men (p = 0.34). As age, body mass index, hypertension, smoking, sports, carrying heavy loads are confounders in both diseases, a multiple logistic regression was performed. There was a relationship between VV and carrying heavy loads, leading to two separated analyses. <h3>Conclusion</h3> When there is no carrying of heavy loads, the RR of KOA is not significantly increased with the presence of VV, while it is when heavy load carriage is also present.
SP0165 The arthrosis project – a three year information project in cooperation with the federation of swedish farmers
Authors: IM Grundin
Journal: Annals of the Rheumatic Diseases (2001)

<h3></h3> The Swedish Government has granted the Swedish Rheumatism Association financial support from the Inheritance Fund to to be used for the purpose of disseminating information about arthrosis. The project is also sponsored by MSD, Pharmacia and Pfizer. The aim of the project is to increase the individual's knowledge of arthrosis and to contribute to a better way of life for people with arthrosis. A further aim is to provide information to the general public and medical staff. We also address outselves to patients with an arthrosis diagnosis and those who belong to risk groups, e g to athletes. The working methods of the project are creative – from the traditional study circle to theatre performances and the production of images and written material. We combine aims and mean, and the creative work is carried out among members and their relatives in our local organisations nationwide. Project activities *Study circles to increase the individual's knowledge of arthrosis *Special "Arthrosis days", information to the public, athletics movement and medical and health services *Information campaigns in conjunction with local arrangements, fairs and exhibitions, etc. *The compilation of a study material which illustrates what living with arthrosis is like and containing a substantial section covering both body and soul Local working groups will act as test groups. *What is arthrosis, research into arthrosis, alternative methods of treatment, prevention, rehabilitation, training, personal and sexual relations *Writer's workshops – writing one's story in prose or poetry as a basis for a manuscript and/or an anthology *Preparing a theatre performance *Special, or separate, exhibitions about arthrosis and the Rheumatism Association, arts, images, sculptures, etc. in different techniques Working constructively and together gives participants strength and a feeling of togetherness. Special "Arthrosis days" with professional lecturers giving audiences all available information about arthrosis. Advertisements in daily newspapers and local placarding together with invitations addressed directly to selected groups are methods to attract listeners. At the "Arthrosis days" participants will be recruited to Arthrosis School study circles. Study circle leaders will be recruited from our own ranks and will be given specific training. The project organisation: A project leader working full-time for 3 years, a steering-group mandated to decide on time, resources and quality issues, reference groups and a groups of researchers to check the project products. The project started in July 2000 in five pilot counties to gather experiences for the benefit of the rest of the country. Recruitment of participants will take place in cooperation with our local associations, the Federation of Swedish Farmers, other local organisations and at local health-care centres.
HPV prevalence in the different subsites of the oropharynx.
Authors: Per Attner
Journal: Journal of Clinical Oncology (2013)

6037 Background: Oropharyngeal cancer patients are often reported as one group in articles and studies regardless that within the subsites of the oropharynx, there are differences regarding clinical features, treatment and HPV prevalence. To investigate these differences, we wanted to further analyze HPV prevalence in the different subsites of the oropharynx. Methods: We identified all patients diagnosed with oropharyngeal cancer in Stockholm County, Sweden, between 2000 and 2007, using the Swedish Cancer Registry, a registry unique in its reliability. Using the ICD 10 codes C01.9 (base of tongue cancer), C09.0-C09.9 (tonsillar cancer) and C10.0-C10.9 (oropharyngeal cancer) and C50.1-C50.8 (cancer of the soft palate). The two last subsites were grouped together into the group Other Oropharyngeal Cancer (OOC). We retrieved pre-treatment biopsies and tested for HPV-DNA using PCR, both with general primers and HPV16 specific primers. Results: We identified 474 patients diagnosed with oropharyngeal cancer in Stockholm County, Sweden between 2000 and 2007; 290 diagnosed with tonsillar cancer, 109 diagnosed with base of tongue cancer and 75 diagnosed with other oropharyngeal cancer. Of these 474 patients, pre-treatment biopsies for HPV-testing were available for 400 patients (236, 95 and 69, respectively). In the tonsillar cancer group, 185 biopsies were HPV-DNA-positive (79%), in the base of tongue cancer group 71 (75%) and in the other oropharyngeal cancer group 17 were positive (25%) Conclusions: Tonsillar and base of tongue cancer share some similarities and HPV prevalence is similarly high in both groups. Other oropharyngeal cancer (OOC) does not share the high HPV-prevalence and it would then be preferred that the sub-sites of the oropharynx are reported separately.
From perinuclear to intranuclear localization: A cell-penetrating peptide modification strategy to modulate cancer cell migration under mild laser irradiation and improve photothermal therapeutic performance
Authors: Ge Gao, Yao-Wen Jiang, Hao-Ran Jia, Wei Sun, Yuxin Guo, Xin-Wang Yu, Xiaoyang Liu, Fu-Gen Wu
Journal: Biomaterials (2019)
Elevated serum IgE, oral corticosteroid dependence and IL-17/22 expression in highly neutrophilic asthma
Authors: Michela Bullone, Vitina Carriero, Francesca Bertolini, Anna Folino, Alessandro Mannelli, Antonino Di Stefano, Isabella Gnemmi, Roberto Torchio, Fabio L.M. Ricciardolo
Journal: European Respiratory Journal (2019)

Information on the clinical traits associated with bronchial neutrophilia in asthma is scant, preventing its recognition and adequate treatment. We aimed to assess the clinical, functional and biological features of neutrophilic asthma and identify possible predictors of bronchial neutrophilia.The inflammatory phenotype of 70 mild-to-severe asthma patients was studied cross-sectionally based on the eosinophilic/neutrophilic counts in their bronchial lamina propria. Patients were classified as neutrophilic or non-neutrophilic. Neutrophilic asthma patients (neutrophil count cut-off: 47.17 neutrophils·mm-2; range: 47.17-198.11 neutrophils·mm-2; median: 94.34 neutrophils·mm-2) were further classified as high (≥94.34 neutrophils·mm-2) or intermediate (47.17- <94.34 neutrophils·mm-2). The effect of smoking ≥10 pack-years was also assessed.Neutrophilic asthma patients (n=38; 36 mixed eosinophilic/neutrophilic) had greater disease severity, functional residual capacity, inhaled corticosteroid (ICS) dose and exacerbations, and lower forced vital capacity (FVC) % pred and forced expiratory volume in 1 s (FEV1) reversibility than non-neutrophilic asthma patients (n=32; 28 eosinophilic and four paucigranulocytic). Neutrophilic asthma patients had similar eosinophil counts, increased bronchial CD8+, interleukin (IL)-17-F+ and IL-22+ cells, and decreased mast cells compared with non-neutrophilic asthma patients. FEV1 and FVC reversibility were independent predictors of bronchial neutrophilia in our cohort. High neutrophilic patients (n=21) had increased serum IgE levels, sensitivity to perennial allergens, exacerbation rate, oral corticosteroid dependence, and CD4+ and IL-17F+ cells in their bronchial mucosa. Excluding smokers revealed increased IL-17A+ and IL-22+ cells in highly neutrophilic patients.We provide new evidence linking the presence of high bronchial neutrophilia in asthma to an adaptive immune response associated with allergy (IgE) and IL-17/22 cytokine expression. High bronchial neutrophilia may discriminate a new endotype of asthma. Further research is warranted on the relationship between bronchoreversibility and bronchial neutrophilia.
How to endoscopically repair a biliodigestive fistula complicating a perforated peptic ulcer: a customized “natural” choledochoduodenal anastomosis
Authors: Laurent Monino, Jean-Michel Gonzalez, Marc Barthet
Journal: Endoscopy (2019)

A perforated peptic ulcer is associated with a 30 % mortality and 50 % morbidity and is usually managed as a surgical emergency [1]. To seal the perforation, applying interrupted sutures with omental apposition is the most commonly used technique [2]. In a few cases, a perforated peptic ulcer may be complicated by a choledochoduodenal fistula, which is managed surgically by laparoscopic digestive resection [3] or medically with a protein pump inhibitor and endoscopic retrograde cholangiopancreatography (ERCP). We present a case of a biliary fistula complicating a perforated peptic ulcer that was managed endoscopically in an original way.
Reduction in First and Total Ischemic Events With Icosapent Ethyl Across Baseline Triglyceride Tertiles
Authors: Deepak L. Bhatt, Ph. Gabriel Steg, Michael Miller, Eliot A. Brinton, Terry A. Jacobson, Lixia Jiao, Jean-Claude Tardif, John Gregson, Stuart J. Pocock, Christie M. Ballantyne
Journal: Journal of the American College of Cardiology (2019)

Triglyceride elevation has re-emerged as a potent marker of residual cardiovascular risk in statin-treated patients [(1)][1]. Converging lines of evidence from epidemiological analyses, Mendelian randomization studies, and outcome data from REDUCE-IT (Reduction of Cardiovascular Events with EPA-
Hsp90B enhances MAST1-mediated cisplatin resistance by protecting MAST1 from proteosomal degradation
Authors: Chaoyun Pan, Jaemoo Chun, Dan Li, Austin C. Boese, Jie Li, JiHoon Kang, Anna Umano, Yunhan Jiang, Lina Song, Kelly R. Magliocca, Zhuo G. Chen, Nabil F. Saba, Dong M. Shin, Taofeek K. Owonikoko, Sagar Lonial, Lingtao Jin, Sumin Kang
Journal: Journal of Clinical Investigation (2019)

Microtubule-associated serine/threonine kinase 1 (MAST1) is a central driver of cisplatin resistance in human cancers. However, the molecular mechanism regulating MAST1 levels in cisplatin-resistant tumors is unknown. Through a proteomics screen, we identified the heat shock protein 90 B (hsp90B) chaperone as a direct MAST1 binding partner essential for its stabilization. Targeting hsp90B sensitized cancer cells to cisplatin predominantly through MAST1 destabilization. Mechanistically, interaction of hsp90B with MAST1 blocked ubiquitination of MAST1 at lysines 317 and 545 by the E3 ubiquitin ligase CHIP and prevented proteasomal degradation. The hsp90B-MAST1-CHIP signaling axis and its relationship with cisplatin response were clinically validated in cancer patients. Furthermore, combined treatment with a hsp90 inhibitor and the MAST1 inhibitor lestaurtinib further abrogated MAST1 activity and consequently enhanced cisplatin-induced tumor growth arrest in a patient-derived xenograft model. Our study not only uncovers the regulatory mechanism of MAST1 in tumors but also suggests a promising combinatorial therapy to overcome cisplatin resistance in human cancers.
Abstract 18015: Rapid Hypothermia Induced by Continuous Renal Replacement Therapy Alleviates Post-Resuscitation Brain Injury in a Porcine Model of Cardiac Arrest
Authors: Mao Zhang, Jiefeng Xu, Qijiang Chen, Xiaohong Jin, Chunshuang Wu, Moli Wang, Zilong Li
Journal: Circulation (2017)

Introduction: The neuroprotective effects of hypothermia have been proven to be partly dependent on the speed of cooling. Recent clinical cases reported that rapid hypothermia using continuous rena...