AB1066 Diabetes mellitus type 2 risk assessment in fibromyalgia women
Authors: O.V. Dzekan, M. Stanislavchuk
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Fibromyalgia (FM) female are less physically active than sedentary healthy women.<sup>1</sup> Low physical activity (PA) is among the leading causes of the major noncommunicable diseases, including diabetes mellitus type 2 (DM2).<sup>2–3</sup> An increased prevalence rate of FM in DM2 patients was revealed.<sup>4–5</sup> Risk of the development of DM2 in FM is unknown. <h3>Objectives</h3> The purpose of this study was to assess the risk of DM2 development in FM women. <h3>Methods</h3> The study involved 67 FM women<sup>ACR 1990</sup> and <sup>2010</sup> criteria) aged 42.6±7.8 (M±SD) yrs without known diabetes, and 51 healthy controls (HCs) (all women) aged 44.8±7.3 years. All participants were asked to complete a modified version of the Finnish Diabetes Risk Score (FINDRISC), which evaluates age, body mass index, waist circumference, current antihypertensive medication, frequency of fruit and vegetable consumption, physical activity, personal history of high blood glucose, and family history of DM2.<sup>6</sup> Fasting plasma glucose (FPG), oral glucose tolerance test (OGTT) and/or glycated haemoglobin (HbA1C) values were collected from all subjects to determine their glucometabolic state. Prediabetes was diagnosed by the presence of impaired FPG (≥100 mg/dL to &lt;126 mg/dL), impaired OGTT (≥140 mg/dL to &lt;200 mg/dL) and/or impaired HbA1c (≥5.7% to ≤6.4%).<sup>7</sup> <h3>Results</h3> According to the FINDRISC questionnaire low risk of DM2 in the next 10 years was found in 14.92% of FM women, intermediate risk—in 22.39%, moderate risk—in 29.85%, high risk—in 23.88%, a very high risk—in 8.96% of patients. In the group of HCs low risk of DM2 was found in 19.61% of women, intermediate risk—in 39.22%, moderate risk—in 21.57%, high risk—in 15.68%, a very high risk—in 3.92% of subjects. Therefore, in most of FM female (53,73%) risk of DM2 was detected as moderate-to-high, while in the majority of HCs (60.79%) it was detected as intermediate-to- moderate. Prediabetes was diagnosed in 11.94% of FM female compared to 5.88% among healthy women. <h3>Conclusions</h3> FM women are found to have increased risk of DM2 development compared to healthy women. <h3>References</h3> [1] McLoughlin MJ, Colbert LH, Stegner AJ, et al. Are women with fibromyalgia less physically active than healthy women?Med Sci Sports Exerc2011;43:905–12. [2] Global action plan for the prevention and control of noncommunicable diseases 2013–2020. Geneva: World Health Organization; 2013 (http://www.who.int/nmh/publications/ncd-action-plan/en/, accessed 12 June 2015). [3] Brugnara L., Murillo S., Novials A., et al. Low Physical Activity and Its Association with Diabetes and Other Cardiovascular Risk Factors: A Nationwide, Population-Based Study. PLoS One. 2016; 11(8): e0160959. Published online 2016Aug 17. doi: 10.1371/journal.pone.0160959 [4] M. Tishler, M. Vazina-Amit, Y. Ramot, T. Smorodin, M. Koffler, and B. Fishel. Fibromyalgia in diabetes mellitus. Rheumatology International, vol. 23, no. 4, pp. 171–173, 2003. [5] M. N. Yanmaz, M. Mert, and M. Korkmaz. The prevalenceof fibromyalgia syndrome in a group of patients with diabetes mellitus. Rheumatology International. April 2012, Volume 32, Issue 4, pp 871–874. [6] Lindström J, Tuomilehto J. The diabetes risk score: a practical tool to predict type 2 diabetes risk. Diabetes Care. 2003;26:725–731. [7] American Diabetes Association. Standards of medical care in diabetes–2014. Diabetes Care. 2014;37Suppl 1:S14–S80. <h3>Disclosure of Interest</h3> None declared