tbuckley/cabot-search huggingface dataset:
Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure
Authors: Laura Michalick, Sarah Weidenfeld, Benjamin Grimmer, Diana Fatykhova, Philip Daniel Solymosi, Felix Behrens, Melanie Dohmen, Markus C. Brack, Sabrina Schulz, Elisa Thomasch, Szandor Simmons, Holger Müller-Redetzky, Norbert Suttorp, Florian Kurth, Jens Neudecker, Mario Toennies, Torsten T. Bauer, Stephan Eggeling, Victor Max Corman, Andreas C. Hocke, Martin Witzenrath, Stefan Hippenstiel, Wolfgang M. Kuebler
Journal: European Respiratory Journal (2020)

<b>The plasma of COVID-19 patients induces pulmonary microvascular barrier failure, which increases with disease severity. Here, a screening platform to test for plasma mediators and the therapeutic potential of barrier stabilising compounds is reported.</b>https://bit.ly/3k4C0tB
Intraoperative Dexamethasone During Pediatric Cardiac Surgery—Reply
Authors: Dmitry Ponomarev, Igor Kornilov, Vladimir Lomivorotov
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Efficacy and Safety of Venetoclax in Combination with Gilteritinib for Relapsed/Refractory <i>FLT3</i>-Mutated Acute Myeloid Leukemia in the Expansion Cohort of a Phase 1b Study
Authors: Naval Daver, Jessica K. Altman, Joseph Maly, Mark Levis, Ellen Ritchie, Mark Litzow, James K. McCloskey, Catherine C. Smith, Gary J. Schiller, Terrence Bradley, Ramon V. Tiu, Wan-Jen Hong, Bo Tong, Qin Qin, Kimberley Dilley, Alexander E. Perl
Journal: Blood (2020)
A Phase 1 Study of Gilteritinib in Combination with Induction and Consolidation Chemotherapy in Patients with Newly Diagnosed AML: Final Results
Authors: Keith W. Pratz, Mohamad Cherry, Jessica K. Altman, Brenda W. Cooper, Jose Carlos Cruz, Joseph G. Jurcic, Mark Levis, Tara Lin, Alexander E. Perl, Nikolai A. Podoltsev, Gary J. Schiller, Jason E. Hill, Angela James, Qiaoyang Lu, Ramon V. Tiu
Journal: Blood (2020)
Survival Following Post-HCT Relapse in Adult Acute Lymphoblastic Leukemia Has Improved in the Era of Novel Immunotherapies: A Single Institution Analysis
Authors: Juliana Craig, Maria Iglesias, Kristen Cunanan, Sally Arai, Matthew J. Frank, Laura J. Johnston, Robert Lowsky, Everett H Meyer, David B. Miklos, Robert S. Negrin, Andrew R. Rezvani, Judith A Shizuru, Surbhi Sidana, W-K Weng, Parveen Shiraz, Lori S. Muffly
Journal: Blood (2020)
Prediction of Clinical Response for Frontline Treatment of Acute Myeloid Leukemia (AML) Patients Using the Cellworks Omics Biology Model (CBM): Mycare-021-02
Authors: Michael Castro, Prashant Ramachandran Nair, Himanshu Grover, Ansu Kumar, Ashish Agarwal, Rakhi Purushothaman Suseela, Reshma P Gopi, Naga Ganesh, Vijayashree P Shyamasundar, Shruthi Kulkarni, Mohammed Sauban, Ashokraja Balla, Srushti P Chafekar, Sayantani Roy Choudhury, Nirjhar Mundkur, Michele Dundas Macpherson, Shweta Kapoor, Scott Howard
Journal: Blood (2020)
TDP-43 proteinopathy impairs mRNP granule mediated postsynaptic translation and mRNA metabolism
Authors: Chia-En Wong, Lee-Way Jin, Yuan-Ping Chu, Wei-Yen Wei, Pei-Chuan Ho, Kuen-Jer Tsai
Journal: Theranostics (2020)

Background: Local protein synthesis and mRNA metabolism mediated by mRNP granules in the dendrites and the postsynaptic compartment is essential for synaptic remodeling and plasticity in neuronal cells.Dysregulation of these processes caused by TDP-43 proteinopathy leads to neurodegenerative diseases, such as frontotemporal lobar degeneration and amyotrophic lateral sclerosis.Methods: Using biochemical analysis and imaging techniques, including super-resolution microscopy, we provide evidence, for the first time, for the postsynaptic localization of TDP-43 in mammalian synapses and we show that TDP-43 is a component of neuronal mRNP granules.Results: With activity stimulation and various molecular approaches, we further demonstrate activity-dependent mRNP granule dynamics involving disassembly of mRNP granules, release of mRNAs, activation of local protein translation, and the impairment of granule disassembly in cellular, animal and human models of TDP-43 proteinopathy. Conclusion:Our study elucidates the interplay between TDP-43 and neuronal mRNP granules in normal physiology and TDP-43 proteinopathy in the regulation of local protein translation and mRNA metabolism in the postsynaptic compartment.
Abstract 295: Genome-wide CRISPR Screen Identifies Keap1-Nrf2 Pathway as a Crucial Regulator for Fibrosis
Authors: toshiyuki nishiji, atsushi hoshino, shunta taminishi, daichi hato, satoaki matoba
Journal: Circulation Research (2020)

Cardiac fibrosis is the pathological feature of myocardial remodeling and clinically involved in various cardiovascular diseases including heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation. Accumulating evidence revealed the molecular mechanism behind organ fibrosis, however, no effective anti-fibrotic therapy has been developed. To find novel anti-fibrotic molecular targets, we performed genome-wide CRISPR library screening with focus on myofibroblast activation. Since a feedforward autocrine loop accelerates myofibroblast differentiation, we employed connective tissue growth factor (CTGF), a center of profibrotic secretome, as a target factor for screening assay. We firstly generated a CTGF-GFP knock-in reporter cell in mesenchymal progenitor cells. The reporter cells were transduced with lentivirus CRISPR library and treated with TGF beta, then high and low GFP signal cells were sorted and sequenced. This screening showed that Keap1-NRF2 pathway was one of the top hits and a novel regulator for CTGF expression. Keap1 knockout attenuated TGF beta-mediated CTGF expression and additional NRF2 knockout cancelled it. Keap1-NRF2 pathway also regulated broadly other profibrotic factors, alpha SMA, periostin, and fibronectin. An activator of NRF2, CDDO-Im treatment had similar effect on TGF beta-mediated profibrotic response. CTGF knockout had little effect on these profibrotic factors, indicating that Keap1-NRF2 is better therapeutic target, as compared with CTGF. Keap1-NRF2 originally reported as a transcriptional regulator for antioxidant and detoxification genes. In silico analysis indicates CTFG promoter has NRF2 response element and ChiP-qPCR experiment confirmed that NRF2 directly regulated CTFG transcriptional expression, not indirectly through antioxidant gene expression. In conclusion, genome-wide screening identified Keap1-NRF2 pathway as a crucial regulator for myofibroblast activation and NRF2 activation might be novel therapy for fibrosis-related diseases.
A Phase 1 Study Evaluating Safety and Tolerability of Navitoclax Monotherapy in Japanese Patients with Myeloproliferative Neoplasms
Authors: Hirohiko Shibayama, Hirokazu Tanaka, Su-Peng Yeh, Hui-Hua Hsiao, Silpa Nuthalapati, Kota Ono, Kotaro Uehara, Sumiko Okubo, Norio Komatsu
Journal: Blood (2020)
The interrelatedness of chronic cough and chronic pain
Authors: Johnmary T. Arinze, Katia M.C. Verhamme, Annemarie I. Luik, Bruno Stricker, Joyce B.J. van Meurs, Guy G. Brusselle
Journal: European Respiratory Journal (2020)

Since chronic cough has common neurobiological mechanisms and pathophysiology with chronic pain, both clinical disorders might be interrelated. Hence, we examined the association between chronic cough and chronic pain in adult subjects in the Rotterdam Study, a large prospective population-based cohort study. Using a standardised questionnaire, chronic pain was defined as pain lasting up to 6 months and grouped into a frequency of weekly/monthly or daily pain. Chronic cough was described as daily coughing for at least 3 months duration. The longitudinal and cross-sectional associations were investigated bi-directionally. Of 7141 subjects in the study, 54% (n=3888) reported chronic pain at baseline. The co-prevalence of daily chronic pain and chronic cough was 4.4%. Chronic cough was more prevalent in subjects with daily and weekly/monthly chronic pain compared with those without chronic pain (13.8% and 10.3% versus 8.2%; p&lt;0.001). After adjustment for potential confounders, prevalent chronic pain was significantly associated with incident chronic cough (OR 1.47, 95% CI 1.08–1.99). The association remained significant in subjects with daily chronic pain (OR 1.49, 95% CI 1.06–2.11) with a similar effect estimate, albeit non-significant in those with weekly/monthly chronic pain (OR 1.43, 95% CI 0.98–2.10). After adjustment for covariables, subjects with chronic cough had a significant risk of developing chronic pain (OR 1.63, 95% CI 1.02–2.62) compared with those without chronic cough. Chronic cough and chronic pain confer risk on each other among adult subjects, indicating that both conditions might share common risk factors and/or pathophysiologic mechanisms.
<i>In Vivo</i> HSC Gene Therapy for Hemoglobinopathies: A Proof of Concept Evaluation in Rhesus Macaques
Authors: Chang Li, Hongjie Wang, Sucheol Gil, Afrodite Georgakopoulou, Stefan Radtke, Evangelia Yannaki, Thalia Papayannopoulou, Hans-Peter Kiem, Andre Lieber
Journal: Blood (2020)
Mitochondrial Spare Reserve Capacity : A New Predictive Metabolic Biomarker for Aggressiveness of Acute Myeloid Leukemia
Authors: Quentin Fovez, Bruno Quesnel, William Laine, Raeeka Khamari, Celine Berthon, Laure Goursaud, Nicolas Germain, Claude Preudhomme, Philippe Marchetti, Jérôme Kluza
Journal: Blood (2020)
Diploid Karyotype Represents a Favorable Prognostic Subgroup in Blast Phase Myeloproliferative Neoplasms
Authors: Sangeetha Venugopal, Srdan Verstovsek, Prithviraj Bose, Naveen Pemmaraju, Lingsha Zhou, Sherry A. Pierce, Hagop M. Kantarjian, Zeev E. Estrov, Lucia Masarova
Journal: Blood (2020)
Major Infections after Blood Transfusion in Isolated Coronary Artery Bypass Surgery Patients: A Meta-Analysis
Authors: Osama Mosalem, Shouq Kherallah, Mark Mujer, Priyal Agarwal, Merryl Treasa Varghese, Ahmed Elshafie, Christopher C Garces, Mahmoud Abdelsamia, Supratik Rayamajhi
Journal: Blood (2020)
Sensitive manipulation of CAR T cell activity using a chimeric endocytosing receptor
Authors: Boning Zhang, John Victor Napoleon, Xin Liu, Qian Luo, Madduri Srinivasarao, Philip S Low
Journal: Journal for ImmunoTherapy of Cancer (2020)

Background Most adoptive cell therapies (ACTs) suffer from an inability to control the therapeutic cell’s behavior following its transplantation into a patient. Thus, efforts to inhibit, activate, differentiate or terminate an ACT after patient reinfusion can be futile, because the required drug adversely affects other cells in the patient. Methods We describe here a two domain fusion receptor composed of a ligand-binding domain linked to a recycling domain that allows constitutive internalization and trafficking of the fusion receptor back to the cell surface. Because the ligand-binding domain is designed to bind a ligand not normally present in humans, any drug conjugated to this ligand will bind and endocytose selectively into the ACT. Results In two embodiments of our strategy, we fuse the chronically endocytosing domain of human folate receptor alpha to either a murine scFv that binds fluorescein or human FK506 binding protein that binds FK506, thereby creating a fusion receptor composed of largely human components. We then create the ligand-targeted drug by conjugating any desired drug to either fluorescein or FK506, thereby generating a ligand-drug conjugate with ~10 -9 M affinity for its fusion receptor. Using these tools, we demonstrate that CAR T cell activities can be sensitively tuned down or turned off in vitro as well as tightly controlled following their reinfusion into tumor-bearing mice. Conclusions We suggest this ‘chimeric endocytosing receptor’ can be exploited to manipulate not only CAR T cells but other ACTs following their reinfusion into patients. With efforts to develop ACTs to treat diseases including diabetes, heart failure, osteoarthritis, cancer and sickle cell anemia accelerating, we argue an ability to manipulate ACT activities postinfusion will be important.
Phase I Trial of a Novel Conditioning Regimen Utilizing Total Marrow Irradiation (TMI) with Fludarabine-Melphalan for Patients with Relapsed Hematologic Malignancies Undergoing Second Allogeneic Stem Cell Transplantation (Allo-SCT)
Authors: Hongtao Liu, Bulent Aydogan, Yasmin Hasan, Amy Wang, Kamil Yenice, Julien Partouche, Wendy Stock, Richard A. Larson, Satyajit Kosuri, James LaBelle, Justin Kline, Peter A. Riedell, Andrew S. Artz, Michael R. Bishop
Journal: Blood (2020)
A Three-Gene Immune Signature Including <i>IDO1</i>, <i>BIN1</i> and <i>PLXNC1</i> Predicts Survival in Acute Myeloid Leukemia
Authors: Simone Ragaini, Sarah Wagner, Giovanni Marconi, Sarah Parisi, Chiara Sartor, Jacopo Nanni, Gianluca Cristiano, Annalisa Talami, Matteo Olivi, Darina Ocadlikova, Marilena Ciciarello, Giulia Corradi, Emanuela Ottaviani, Cristina Papayannidis, Stefania Paolini, Jayakumar Vadakekolathu, Michele Cavo, Sergio Rutella, Antonio Curti
Journal: Blood (2020)
Metabolomic profiling reveals amino acid and carnitine alterations as metabolic signatures in psoriasis
Authors: Chao Chen, Guixue Hou, Chunwei Zeng, Yan Ren, Xiang Chen, Cong Peng
Journal: Theranostics (2020)

High-throughput metabolite profiling provides the opportunity to reveal metabolic mechanisms and identify biomarkers.Psoriasis is an immune-mediated chronic inflammatory disease.However, the role of metabolism in psoriasis pathogenesis remains unclear.Methods: Plasma samples of individuals (45 psoriasis and 45 sex-, age-, and BMI-matched healthy controls) were collected.Non-targeted metabolomics and amino acid-or carnitine-targeted metabolomics were conducted, then, plasma samples of mice induced by imiquimod (IMQ) were subjected to the amino acid-and carnitine-targeted metabolomic profiling.Flow cytometry was used to study the effect of L-carnitine (LC(C0)) on IMQ-induced psoriatic inflammation.Results: Through the non-targeted metabolomics approach, we detected significantly altered amino acids and carnitines in psoriasis patients.Amino acid-targeted metabolomic profiling identified 37 amino acids altered in psoriasis, of these 23 were markedly upregulated, including essential amino acids (EAAs), and branched-chain amino acids (BCAAs), whereas glutamine, cysteine, and asparagine were significantly down-regulated.Carnitine-targeted metabolomic profiling identified 40 significantly altered carnitines, 14 of which included palmitoylcarnitine (C16) and were markedly downregulated in psoriasis, whereas hexanoylcarnitine (C6) and 3-OH-octadecenoylcarnitine (C18:1-OH) were significantly upregulated.Interestingly, glutamine, asparagine, and C16 levels were negatively correlated with the PASI score.Moreover, a higher abundance of LC(C0) was associated with markedly reduced IMQ-induced epidermal thickening and infiltration of Th17 cells in skin lesions, indicating LC(C0) supplementation as a potential therapy for psoriasis treatment.Conclusion: Our results suggested the metabolism of amino acids and carnitines are significantly altered in psoriasis, especially the metabolism of EAAs, BCAAs, and LC(C0), which may play key roles in the pathogenesis of psoriasis.
Personalized Transcriptomic Analyses Identify Unique Signatures That Correlate with Genomic Subtypes in Acute Myeloid Leukemia (AML) Using Explainable Artificial Intelligence
Authors: Yazan Rouphail, Nathan Radakovich, Jacob Shreve, Sudipto Mukherjee, Babal K. Jha, Jaroslaw P. Maciejewski, Mikkael A. Sekeres, Aziz Nazha
Journal: Blood (2020)
Multiparameter Flow Cytometry (MFC) of Cerebrospinal Fluid (CSF) from Adults Receiving Hypercvad for Acute Lymphoblastic Leukemia/Lymphoma (ALL) Identifies Patients at Higher Risk of Central Nervous System (CNS) Relapse: A Single-Center Retrospective Analysis
Authors: Kelsey-Leigh A Garcia, Philip A. Stevenson, Sindhu Cherian, Christen N. Martino, Andrei R Shustov, Pamela S. Becker, Mary-Beth M. Percival, Vivian G. Oehler, Anna B. Halpern, Roland P Walter, Johnnie Orozco, Colin D. Godwin, Sioban Keel, Elihu H. Estey, Ryan D. Cassaday
Journal: Blood (2020)
Macaque CRISPR/Cas9 Age-Related Clonal Hematopoiesis Model Demonstrates Expansion of TET2-Mutated Clones and Applicability for Testing Mitigation Approaches
Authors: Taehoon Shin, Shirley Chen, Stefan Cordes, Yifan Zhou, Byung-Chul Lee, Aisha Aljanahi, So Gun Hong, Robert E. Donahue, Kyung-Rok Yu, Cynthia E. Dunbar
Journal: Blood (2020)
Recovery of Ocular Events with Longer-Term Follow-up in the DREAMMM-2 Study of Single-Agent Belantamab Mafodotin (Belamaf) in Patients with Relapsed or Refractory Multiple Myeloma (RRMM)
Authors: Sagar Lonial, Ajay Nooka, Praneetha Thulasi, Ashraf Z. Badros, Bennie H. Jeng, Natalie S. Callander, Douglas Sborov, Brian E. Zaugg, Rakesh Popat, Simona Degli Esposti, Julie Byrne, Joanna Opalinska, January Baron, Trisha Piontek, Ira Gupta, Reza Dana, Asim Farooq, Andrzej Jakubowiak
Journal: Blood (2020)
Vedolizumab for Steroid Refractory Lower Gastrointestinal Tract Graft Versus Host Disease
Authors: Rohtesh S. Mehta, Rima M. Saliba, Anna Jan, Terri Lynn Shigle, Emily Wang, Gabriela Rondon, Yago Nieto, Stefan Ciurea, Betul Oran, Jin S. Im, Amanda L. Olson, David Marin, Muzaffar H. Qazilbash, Issa F. Khouri, Paolo Anderlini, Katayoun Rezvani, Uday R. Popat, Partow Kebriaei, Elizabeth J. Shpall, Richard E. Champlin, Amin M. Alousi
Journal: Blood (2020)
BCR-ABL1 Levels at First Month after TKI Discontinuation Predict Subsequent Maintenance of Treatment-Free Remission: A Study from the "Gruppo Triveneto LMC"
Authors: Sara Di Giusto, Eleonora Toffoletti, Massimiliano Bonifacio, Gianni Binotto, Maria Cristina Miggiano, Elisabetta Calistri, Manuela Stulle, Anna Ermacora, Rossella Stella, Luigi Scaffidi, Fabio D'Amore, Giorgia Scotton, Giovanna De Matteis, Roberta Bertorelle, Renato Fanin, Mauro Krampera, Gianpietro Semenzato, Daniela Damiani, Mario Tiribelli
Journal: Blood (2020)
Outcomes in Vaso-Occlusive Crisis Treatment in the Emergency Department Vs. Acute Care Observation Center
Authors: Renee Cheng, Avani Singh, Xu Zhang, Priyanka Nasa, Jin Han, Doris Alfaro, Laura Kavoliunaite, Chika Nwachukwu, Karen Woodard, Robert E. Molokie, Victor R. Gordeuk, Michel Gowhari
Journal: Blood (2020)
Long-Term Results of the Treatment of Persons with Hodgkin's Lymphoma in a Resource-Constrained Setting: Real-World Data from a Single Center
Authors: Luisa Fernanda Sánchez-Valledor, Thomas M. Habermann, Iván Murrieta-Álvarez, Andrés A. León-Peña, Yahveth Cantero-Fortiz, Carmina Alejandra Córdova-Ramírez, Montserrat Rivera-Álvarez, Juan Carlos Olivares-Gazca, Guillermo J. Ruiz-Delgado, Guillermo J. Ruiz-Arguelles
Journal: Blood (2020)
Systematic Evaluation of Somatic <i>Cis</i>-Regulatory Mutations in Follicular Lymphoma
Authors: Firat Uyulur, Findlay Bewicke-Copley, Chinedu Anthony Anene, Matthias Schlesner, Icgc MMML-Seq Project, Reiner Siebert, Jessica Okosun, Jude Fitzgibbon, Jun Wang
Journal: Blood (2020)
Adult Hemophagocytic Lymphohistiocytosis(HLH): Experience of an Urban, Public Hospital over Two Decades
Authors: Shristi Upadhyay Banskota, Andres E Mendez-Hernandez, Hafeez Shaka, Prasanth Lingamaneni, Binav Baral, Garima Pudasaini, Maryam Zia
Journal: Blood (2020)
Fetal Hemoglobin Mediates the Effect of Beta Globin Gene Polymorphisms on Neurocognitive Functioning in Sickle Cell Disease
Authors: Andrew M Heitzer, Jennifer Longoria, Evadnie Rampersaud, Sara Rashkin, Jeremie H. Estepp, Victoria Okhomina, Winfred Wang, Darcy Raches, Brian Potter, Allison A. King, Guolian Kang, Jane S. Hankins
Journal: Blood (2020)
Donor Selection May Predict Improved Survival Outcomes after Allogeneic Hematopoietic Stem Cell Transplantation in Chronic Myelomonocytic Leukemia - Experience from a Tertiary Care Centre
Authors: RAM V Nampoothiri, Carol Chen, Zeyad Al-Shaibani, Ivan Pasic, Arjun Law, Wilson Lam, Fotios Michelis, Dennis Dong Hwan Kim, Armin Gerbitz, Auro Viswabandya, Jeffrey H. Lipton, Jonas Mattsson, Rajat Kumar, Santhosh Thyagu
Journal: Blood (2020)
Non-surgical management of knee osteoarthritis: comparison of ESCEO and OARSI 2019 guidelines
Authors: Nigel K. Arden, Thomas A. Perry, Raveendhara R. Bannuru, Olivier Bruyère, Cyrus Cooper, Ida K. Haugen, Marc C. Hochberg, Timothy E. McAlindon, Ali Mobasheri, Jean-Yves Reginster
Journal: Nature Reviews Rheumatology (2020)
Inclacumab, a Fully Human Anti-P-Selectin Antibody, Directly Binds to PSGL-1 Binding Region and Demonstrates Robust and Durable Inhibition of Cell Adhesion
Authors: Xin Geng, Radu Mihaila, Yue Yuan, Steven Strutt, Jörg Benz, Tzechiang Tang, Christina Mayer, Donna Oksenberg
Journal: Blood (2020)
Clinical Development of a Non-Gene-Edited Allogeneic Bcma-Targeting CAR T-Cell Product in Relapsed or Refractory Multiple Myeloma
Authors: A. Samer Al-Homsi, Sebastien Anguille, Jason Brayer, Dries Deeren, Nathalie Meuleman, Gareth Morgan, Taiga Nishihori, Panagiota A. Sotiropoulou, Laure Twyffels, Jennifer Bolsee, Nathalie Braun, Caroline Lonez, David E Gilham, Anne Flament, Frédéric F. Lehmann
Journal: Blood (2020)
Unsupervised Flow Cytometry Analysis: Application to Minimal Residual Disease Detection in a Cohort of 40 Acute Myeloblastic Leukemia Patients with Molecular Markers
Authors: Nicolas Lechevalier, Jean-Philippe Vial, Francis Lacombe, Pierre-Yves Dumas, Audrey Bidet, Thibaut Leguay, Francois Vergez, Arnaud Pigneux, Marie C Béné
Journal: Blood (2020)
The Commands Trial: A Phase 3 Study of the Efficacy and Safety of Luspatercept Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low-, Low-, or Intermediate-Risk MDS in Erythropoiesis Stimulating Agent-Naive Patients Who Require RBC Transfusions
Authors: Matteo Della Porta, Uwe Platzbecker, Valeria Santini, Guillermo Garcia-Manero, Rami S. Komrokji, Rodrigo Ito, Pierre Fenaux
Journal: Blood (2020)
Saliva collected in universal transport media is an effective, simple and high-volume amenable method to detect SARS-CoV-2
Authors: Byron M. Berenger, John M. Conly, Kevin Fonseca, Jia Hu, Thomas Louie, Angela R. Schneider, Takshveer Singh, William Stokes, Linda Ward, Nathan Zelyas
Journal: Clinical Microbiology and Infection (2020)
Daratumumab after Allogeneic Hematopoietic Stem Cell Transplantation in Multiple Myeloma: Safety and Efficacy. a Retrospective Study from the Cmwp EBMT
Authors: Laure Vincent, Luuk Gras, Patrice Ceballos, Jürgen Finke, Jakob Passweg, Marie Robin, Laura Rosinol, Monique C. Minnema, Raphael Teipel, JA Van Deosum, Mathias Haenel, Pascal Lenain, Edouard Forcade, Christian Koenecke, Sophie Ducastelle, Jaime Sanz, Wilfried Schroyens, Tsila Zuckerman, Marco Ladetto, Linda Koster, Liesbeth C. de Wreede, Patrick J Hayden, Stefan Schönland, Ibrahim Yakoub-Agha, Meral Beksac
Journal: Blood (2020)
Real-World Treatment Patterns in Patients with Light Chain (AL) Amyloidosis: Analysis of the Optum US Electronic Health Records and Commercial Claims Database
Authors: Angela Dispenzieri, Jeff Zonder, James Hoffman, Sandy W. Wong, Michaela Liedtke, Rafat Abonour, Anita D'Souza, Charlene Lee, Sandhya Nair, Ravi Potluri, Brendan M. Weiss, Jessica Vermeulen, Annette Lam, Maneesha Mehra
Journal: Blood (2020)