FRI0545 HEMODYNAMIC MEASUREMENTS AND ARTERIAL STIFFNESS IN PATIENTS WITH JUVENILE IDIOPATIC ARTHRITIS COMPARED TO CHILDREN WITHOUT JUVENILE IDIOPATIC ARTHRITIS
Authors: Jorge E. Rubio Silveira, C. Araceli Arellano Valdez, Carlos Ramos Becerra, Myriam Mendez Nuñez, David Cardona Müller, Oscar Mares Flores, Priscila Vega García, Fernando Grover Páez, Alberto Tlacuilo Parra
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> Juvenile Idiopathic Arthritis (JIA) can cause long-term cardiovascular complications. There are non-invasive, validated, easy to perform methods for cardiovascular testing, such as: carotid intimal-media thickness (cIMT), and measurement of arterial rigidity through carotid distensibility, carotid-femoral pulse wave velocity (cfPWV) and the augmentation index (AIx). <h3>Objectives</h3> To compare the main hemodynamics measurements (cIMT, carotid distensibility, cfPWV and AIx) between JIA and non-JIA subjects. <h3>Methods</h3> Analytical cross-sectional study in subjects 5 to 16 years of age. Two groups: patients with JIA according to the ILAR classification without any other condition <i>vs</i> healthy children. Measurements: somatometry, laboratory (glucose, creatinine, lipid profile), disease activity index (JADAS-27) and hemodinamic variables (cIMT, carotid distensibility, cfPWV and AIx). <h3>Results</h3> 63 JIA subjects and 50 healthy controls were included, mean age 11.5 ± 2.8 <i>vs</i> 10.7 ± 3.2 years (<i>p</i> = 0.17) and 70% vs 54% females, respectively. Both groups were also similar (p &gt; 0.05) for nutritional state, sedentary lifestyle, smoking habits and family history of cardiovascular risk. Table 1 show lipid profile of both groups. Subtypes of JIA were: RF positive polyarthritis (29%), RF negative polyarthritis (29%), oligoarthritis (19%), enthesitis-related arthritis (14%) and systemic arthritis (9%). Mean time of disease evolution was 4 ± 3 años. There were no significant differences between groups in the main hemodinamic parameters (table 2). When comparing inactive <i>vs</i> active disease and active disease <i>vs</i> controls there were no differences either, we found a discrete trend to less carotid distensibility and higher cfPWV in patients with active disease compared to controls [0.63 ± 0.17 mm vs 0.66 ± 0.15 mm (<i>p</i> = 0.94) and 6.12 ± 2.88 m/s <i>vs</i> 5.42 ± 0.75 m/s (<i>p</i> = 0.33), respectively]. 59% of subjects with JIA were inactive according to JADAS-27. When considering time of disease evolution, children with 0-4 years <i>vs</i> children with &gt;4 years and children with &gt;4 years <i>vs</i> controls, we found differences in cIMT [0.41 ± 0.62 mm <i>vs</i> 0.44 ± 0.50 mm (p = 0.02) and 0.44 ± 0.50 mm vs 0.40 ± 0.70 mm (p = 0.01), respectively]. Finally, cfPWV was higher in patients with 0-4 years than in patients with &gt;4 years of evolution (p = 0.01). <h3>Conclusion</h3> We found a tendency to increased cardiovascular risk when the disease has more than 4 years of evolution, specially in patients with persistent active disease. Traditional and non-traditional cardiovascular risk factors add up in this population. We need longterm follow-up studies. <h3>References</h3> [1] Bohr AH, Fuhlbrigge RC, Pedersen FK, De Ferranti SD, Müller K. Premature subclinical atherosclerosis in children and young adults with juvenile idiopathic arthritis. A review considering preventing measures. Pediatr Rheumatol2016; 14: 1-5. [2] Sozeri B, Atikan BY, Ozdemir K, Mir S. Assessment of vascular function in systemic onset juvenile idiopathic arthritis. Clin Rheumatol2016; 35: 1699-1703. <h3>Disclosure of Interests</h3> Jorge E. Rubio Silveira Grant/research support from: Grants from Roche and Abbvie for some national meetings, C. Araceli Arellano Valdez Grant/research support from: Grants from Roche for multiple national and international meetings., Speakers bureau: different conferences about Tocilizumab in meetings., Carlos Ramos Becerra: None declared, Myriam Mendez Nuñez: None declared, David Cardona Müller: None declared, Oscar Mares Flores: None declared, Priscila Vega García: None declared, Fernando Grover Páez: None declared, Alberto Tlacuilo Parra: None declared