tbuckley/cabot-search huggingface dataset:
ADTH-08 Robot magnet-controlled upper gastrointestinal capsule endoscopy: non-invasive investigation with excellent patient tolerance
Authors: Hey-long Ching, David Tai, Melissa F Hale, Reena Sidhu, Mark E McAlindon
Journal: Endoscopy (2018)

<h3>Introduction</h3> Gastroscopy (OGD) is invasive and not always well tolerated. The NaviCam<sup>®</sup> (Ankon Technologies Co. Ltd., Shanghai, China) combines capsule endoscopy technology with external robot magnetic control. Operator joysticks command the robot to steer the capsule within the stomach. Real-time visualisation is displayed on two workstation monitors. When compared to OGD, the NaviCam<sup>®</sup> has already demonstrated high sensitivity and specificity for identifying focal gastric lesions.<sup>1</sup> The focus of this study was to grade imaging quality and patient tolerance of the NaviCam<sup>®</sup>. <h3>Method</h3> Patients with dyspepsia were recruited. Patients swallowed 100 mls of water (containing 10 mls simethicone) 15 min prior to 1L of water followed by the NaviCam<sup>®</sup>. Clarity of views and adequacy of gastric distension were assessed (1, poor; 2, reasonable; 3, good), as was completeness of views of the oesophagogastric mucosa (1,&gt;75% obscured; 2,&gt;50% obscured; 3,&lt;50% obscured; 4,&lt;25% obscured; 5, 100% visualised). Patient tolerance scores were collected (worst-best=0–10). All patients subsequently had OGD and tolerance scores were compared to those of the NaviCam<sup>®</sup>. <h3>Results</h3> Eighteen participants were included (mean age 53±16.1 years, 27.8% male). The NaviCam could be held stationary within the stomach (resisting peristaltic waves) and could cartwheel over rugal folds to a chosen proximal location using a preset programme activated by a 'shoot' button on the joystick. Mean examination duration was 25±3.4 mins. Mean clarity (2.3±0.7) and distension scores (2.9±0.3) were good. Complete views (5±0) for all areas of the gastric body (greater and lesser curvature, anterior and posterior wall) and distal stomach (antrum and pylorus) were achieved. Views of the oesophagus (4.3±1.3) and proximal stomach (cardia, 4.9±0.2; fundus 4.8±0.3) were also good. Duodenal images were not assessed real-time (but are provided after the capsule traverses the pylorus). Tolerance scores for anxiety, discomfort and pain were all lower with MACE compared to OGD (2.2±1.4 vs 5.8±3, 1.3±1 vs 4.9±3, 2.4±2.4 vs 3.4±2.5, respectively; p&lt;0.05 for all). Tolerance scores for undesirable symptoms associated with upper gastrointestinal (GI) endoscopy, namely gagging, choking and bloating were also more favourable with MACE compared to OGD (1.4±1.6 vs 5.4±3.3, 1.3±1.2 vs 4.8±3.3, 1.2±0.5 vs 2.9±2.0, respectively; p&lt;0.05 for all). <h3>Conclusion</h3> The NaviCam<sup>®</sup> demonstrates excellent oesophagogastric views. The NaviCam<sup>®</sup> is extremely well tolerated compared to OGD and patients experience significantly fewer undesirable symptoms associated with upper GI endoscopy. <h3>Reference</h3> . Liao Z, et al. Clin Gastroenterol Hepatol2016;14(9):1266–73.e1.
Recommendations for the management of hemophagocytic lymphohistiocytosis in adults
Authors: Paul La Rosée, AnnaCarin Horne, Melissa Hines, Tatiana von Bahr Greenwood, Rafal Machowicz, Nancy Berliner, Sebastian Birndt, Juana Gil-Herrera, Michael Girschikofsky, Michael B. Jordan, Ashish Kumar, Jan A. M. van Laar, Gunnar Lachmann, Kim E. Nichols, Athimalaipet V. Ramanan, Yini Wang, Zhao Wang, Gritta Janka, Jan-Inge Henter
Journal: Blood (2019)
Abstract MP039: Association Between Estimated 24-hour Urinary Sodium and Potassium Excretion and Blood Pressure in a Japanese Cohort: a Repeated Measure Analysis
Authors: Trang Nguyen, Katsuyuki Miura, Sachiko Tanaka, Taichiro Tanaka, Yasuyuki Nakamura, Aya Kadota, Junko Tamaki, Toru Takebayashi, Tonomori Okamura, Hirotsugu Ueshima
Journal: Circulation (2017)

Background: While measurement of sodium (Na) and potassium (K) from the collection of urine over a 24-hour period are associated with blood pressure, relationships with 24-hour urinary excretion estimates from more conveniently collected spot urine samples are less clear. Objectives: The purpose of this report is to examine the association of estimated 24-hour excretion of Na, K and their ratio from annually repeated spot urine samples with systolic (SBP) and diastolic (DBP) blood pressures. Methods: Data include 4,958 normotensive Japanese aged 19 to 55 years who participated in annual physical examinations over a 5-year period in the High-Risk and Population Strategy for Occupational Health Promotion Study (1999-2004). At each examination, spot urine samples were collected in the morning and blood pressure was measured following standardized procedures. 24-hour urinary excretion of Na and K were estimated from spot urine specimens using the formula of Tanaka. Adjustments were made for potential confounding from demographic, lifestyle education, body mass index, smoking, alcohol consumption and physical activity. Mixed-effects regression models were used to examine the association of the estimated 24-hour excretion of Na, K, and the sodium-to-potassium (Na:K) ratio with SBP and DBP over the 5-year period of study. Results: A one standard deviation (SD) increase in the estimated 24-hour excretion of Na (36.6 mmol/day) was associated with a 1.3 mm Hg higher SBP and a 0.8 mm Hg higher DBP (P&lt;.001). The association between Na and SBP was greater in men (1.4 mm Hg per SD) than in women (0.9 mm Hg per SD, P=.003 for interaction) and increased with age (1.0 mm Hg per SD at &lt;35 years of age, 1.2 mm Hg per SD at 35 to 45 years of age, and 1.8 mm Hg per SD at &gt;45 years of age, P&lt;.001 for interaction). Estimated 24-hour excretion of K was inversely associated with blood pressure where a one SD increase (8.9 mmol/day) was associated with a 1.1 mm Hg lower SBP and 0.7 mm Hg lower DBP (P&lt;.001). Unlike the estimated 24-hour excretion of Na, interactions between K and age or sex were absent. Estimated 24-hour Na:K ratio were positively associated with SBP and DBP, with greater effects in men than in women and increasing positive associations with age (P&lt;.01 for each interaction). Conclusions: Estimated 24-hour excretion of Na, K, and the Na:K ratio from spot urine samples have significant associations with blood pressure. Findings suggest that the less costly and more convenient collection of spot urine samples for estimating excretion of Na, K, and their ratio over a 24-hour period may be an efficient way of monitoring these electrolytes in large population-based samples.
Abstract P079: Biological Markers of Stress and Unhealthy Assimilation Behaviors Vary According to Reason for Immigration: the Africans in America Study
Authors: Rafeal L Baker, Jean N Utumatwishima, Brianna A Bingham, Madia Ricks, Lilian S Mabundo, Margaret Udahogora, David Berrigan, Stephanie T Chung, Anne E Sumner
Journal: Circulation (2017)

The relationship between the biological effect of stress, reason for immigration and unhealthy assimilation behaviors has not been studied in African immigrants to the United States. Therefore, in 88 African immigrants to the United States (age 41±10, (mean±SD), range 22-61y, male 65% (57 of 88)) we used the allostatic load score (ALS) to assess the biological response to stress. ALS was calculated using 10 variables from 3 domains; cardiac (SBP, DBP, cholesterol, triglyceride, homocysteine), metabolic (BMI, A1C, albumin, eGFR) and immunological (hsCRP). High-risk was defined by the highest quartile for each variable, except for albumin and eGFR, which used the lowest quartile. One point was assigned if the variable was in the high-risk range and 0 if not. Participants were grouped by reason for immigration: asylum, work, study, marriage, lottery and family reunification. Unhealthy assimilation behaviors were: smoking and alcohol intake. ALS was highest for asylum seekers (3.21±2.16) and lowest for family reunification (1.78±1.35). For the other reasons of immigration, ALS was in the range between these two scores (Figure). Thirty-six percent of asylum seekers were smokers (5 of 14), whereas all other African immigrants were non-smokers (0 of 74) ( P &lt;0.001). Similarly, self-reported alcohol intake was higher for asylum seekers than for the other reasons for immigration (43% (6 of 14) vs.22% (16 of 74), P =0.05). In conclusion, as demonstrated by ALS, asylum seekers experience the highest degree of stress and the most unhealthy assimilation behaviors. However, Africans who come to the United States for family reunification have a low prevalence of unhealthy assimilation behaviors and the lowest ALS. Therefore, reason for immigration may have a significant impact on both health and behavior.
Highly photostable two-photon NIR AIEgens with tunable organelle specificity and deep tissue penetration
Authors: Guangle Niu, Ruoyao Zhang, Yuan Gu, Jianguo Wang, Chao Ma, Ryan T.K. Kwok, Jacky W.Y. Lam, Herman H.-Y. Sung, Ian D. Williams, Kam Sing Wong, Xiaoqiang Yu, Ben Zhong Tang
Journal: Biomaterials (2019)
Feasibility of a multi-disciplinary rehabilitation program for post treatment cancer patients: A pilot study.
Authors: Cloé Brami, François Salignon, Camille Le Bris, Nedia Tanazefti, Nathalie Lhuillier, Hélène de La Ménardière, Jérôme Alexandre, Francois Goldwasser, Jean-Philippe Durand
Journal: Journal of Clinical Oncology (2015)

e20627 Background: Evidence suggested that lifestyle factors included physical activity (PA) and diet are associated with better outcomes in cancer patient (pt). Thus, gain weight after treatment (trt) increased the risk of recurrence in breast and colorectal cancer pt. These data prompt us to integrate PA and healthier diet in cancer care. Our aim was to assess the feasibility of a multi-disciplinary coordinated pilot program, including PA, nutritional and psychological counseling after cancer trt. Methods: A pilot study was conducted in pts who completed trt for at least 1 month. Pts entered in this program after a dedicated medical consultation. Exclusion criteria were cardiorespiratory or muscular/articular limits for PA. Participants follow a personalized pre-specified exercise schedule: 12 sessions of 60 minutes resistance training and aerobic exercises, twice a week during 6 weeks, combined with 3 sessions of dietary counseling (calory and nutrient intake, weight) and psychological support. Maximal oxygen consumption (V02max), maximum aerobic speed (MAS) and maximum power (Pmax) were assessed on a cycle ergometer at baseline, week 3 and 6. Fatigue was estimated with the Brief Fatigue Inventory (BFI) at the same time. Results: Between 01/2013 and 12/2014, we enrolled 40 pts (women: 23 ; median age: 54.5 years [21.7-73.1y]) with breast (24%), ovarian (21%), sarcoma (18%), lung (15%), others (22%) cancers. 5 (15.2%) pts were metastatic. All pts were PS 0-1. 67% of the pts had a normal BMI. Last cancer trt prior inclusion was: chemotherapy (52%), radiotherapy (24%), surgery (15%). Median time between last trt and inclusion was 5.9 months. 33 pts (82.5%) achieved the whole program. Mean duration for the 12 training sessions was 9.2 weeks (4.6-16). At the end of training period, aerobic function improved with an increase of V02max (25.45 vs 21.71 ml/min/kg ; p = 0 ,0004), MAS (8.83 vs 7.4 km/h ; p < 0.0001) and Pmax (170.93 vs 153.89 W ; p = 0,0001). BFI scores decreased significantly (21.1 vs 34.2 ; p = 0,0001). Conclusions: A multi-disciplinary rehabilitation program is feasible in pre-treated cancer pt. Significant impact was observed on physical outcomes and confirmed the positive effect on fatigue.
Effects of Programmed Local Delivery from a Micro/Nano‐Hierarchical Surface on Titanium Implant on Infection Clearance and Osteogenic Induction in an Infected Bone Defect
Authors: Dize Li, Yihan Li, Annie Shrestha, Si Wang, Qingqing Wu, Lingjie Li, Chao Guan, Chao Wang, Tiwei Fu, Wenzhao Liu, Yuanding Huang, Ping Ji, Tao Chen
Journal: Advanced Healthcare Materials (2019)

The two major causes for implant failure are postoperative infection and poor osteogenesis. Initial period of osteointegration is regulated by immunocytes and osteogenic-related cells resulting in inflammatory response and tissue healing. The healing phase can be influenced by various environmental factors and biological cascade effect. To synthetically orchestrate bone-promoting factors on biomaterial surface, built is a dual delivery system coated on a titanium surface (abbreviated as AH-Sr-AgNPs). The results show that this programmed delivery system can release Ag+ and Sr2+ in a temporal-spatial manner to clear pathogens and activate preosteoblast differentiation partially through manipulating the polarization of macrophages. Both in vitro and in vivo assays show that AH-Sr-AgNPs-modified surface renders a microenvironment adverse for bacterial survival and favorable for macrophage polarization (M2), which further promotes the differentiation of preosteoblasts. Infected New Zealand rabbit femoral metaphysis defect model is used to confirm the osteogenic property of AH-Sr-AgNPs implants through micro-CT, histological, and histomorphometric analyses. These findings demonstrate that the programmed surface with dual delivery of Sr2+ and Ag+ has the potential of achieving an enhanced osteogenic outcome through favorable immunoregulation.
THU-055-Improved stratification of liver failure syndromes using broad-panel bile acid LCMS phenotyping demonstrates novel pathways of dysregulation in tertiary bile acids in acute-on-chronic liver failure
Authors: Kate Wolfer, Matthew Lewis, Dr Magali Sarafian, David RTaylor, Royce Vincent, Vishal C Patel, MarkJ W McPhail
Journal: Journal of Hepatology (2019)
Pancreatic Islet Transplantation: Development of a Coaxial 3D Printing Platform for Biofabrication of Implantable Islet‐Containing Constructs (Adv. Healthcare Mater. 7/2019)
Authors: Xiao Liu, Sarah‐Sophia D. Carter, Max Jurie Renes, Juewan Kim, Darling Macarena Rojas‐Canales, Daniella Penko, Cameron Angus, Stephen Beirne, Christopher John Drogemuller, Zhilian Yue, Patrick T. Coates, Gordon G. Wallace
Journal: Advanced Healthcare Materials (2019)

In article number 1801181 by Zhilian Yue, Patrick T. Coates, Gordon G. Wallace, and co-workers, a coaxial bioprinting platform is developed for fabrication of islet-containing constructs. With precision control over the location of multiple cells, the coaxial printed constructs may provide protection to the encapsulated islets in the core while simultaneously delivering multiple supporting cells into the shell. This novel strategy has the potential to improve revascularization and provide immune-protection to the implanted islets.
Stephan Elias Tchamouroff
Authors: Tanya Tier
Journal: BMJ (2019)

Stephan Elias Tchamouroff was born in Jerusalem to Bulgarian parents. After joining the Jordanian army he was sent on a scholarship to study medicine at St Bartholomew’s Hospital, London. During his time as a medical student, Stephan also trained for a period as a singer under the conductor Sir Thomas Beecham. However, he eschewed a career as a tenor to pursue his first love, medicine.

On his return to Jordan, Stephan was appointed medic on location …
EphA2 receptor tyrosine kinase is a tumor suppressor gene in mammalian skin
Authors: Hong Guo, Hui Miao, Lizabeth Gerber, Jarnail Singh, Mitchell F. Denning, Anita C. Gilliam, Bing-Cheng Wang
Journal: Cancer Research (2006)

3962  Overexpression of EphA2 receptor tyrosine kinase is frequently detected in many common types of human cancer and has been correlated with tumor prognosis. This has led to the suggestion that EphA2 is an oncoprotein. This notion predicts that EphA2 gene deletion in vivo will lead to reduced tumor susceptibility. Surprisingly, we report here that EphA2 knockout mice exhibited dramatically increased susceptibility to skin tumorigenesis in the classical DMBA/TPA two-stage carcinogenesis model. Deletion of EphA2 led to several fold increase in tumor multiplicity and significantly shortened tumor latency. Further, tumors in homozygous knockout mice showed significantly accelerated growth and malignant progression toward invasive squamous cell carcinoma. Loss of EphA2 did not appear to affect apoptosis, but was associated with increased tumor cell proliferation. Treatment of primary keratinocytes from wild type mice with ephrin-A1 inhibited ERK1/2 activities and suppressed cell growth; both effects were abolished in EphA2-null keratinocytes. Similar to human cancers, EphA2 expression was elevated in tumor parenchyma compared with adjacent normal tissues, possibly as a result of oncogenic activation of Ras, which is prevalent in DMBA-induced skin tumors and is known to promote transcriptional activation of EphA2 expression. These results demonstrate that EphA2 is a novel tumor suppressor gene in mammalian skin. Overexpression of EphA2 in tumors may represent a compensatory feedback mechanism to negatively regulate tumor growth and progression.
SAT-313-Exosomal miRNA analysis for classifying severity of disease in biopsy-proven NAFLD patients
Authors: Young-Sun Lee, Sung Won Chang, Ha Seok Lee, Sehwa Kim, Haein Bak, Min-jin Lee, Young Kul Jung, Ji Hoon Kim, Yeon Seok Seo, Hyung Joon Yim, Jong Eun Yeon, Soon Ho Um, Kwan Soo Byun
Journal: Journal of Hepatology (2019)
FRI-311-Gut lymphatic vascular disorder associates with severity of cirrhosis in non-alcoholic fatty liver disease
Authors: Savneet Kaur, Dinesh M Tripathi, Sumati Rohilla, Preety Rawal, Rajan Vijayraghavan, Archana Rastogi, Sm Shasthry, Shiv K Sarin
Journal: Journal of Hepatology (2019)
Annals Story Slam - A Variation on the Lipstick Sign
Authors: Maria Maldonado
Journal: Annals of Internal Medicine (2019)

Web Exclusives7 May 2019Annals Story Slam - A Variation on the Lipstick SignFREEMaria Maldonado, MDMaria Maldonado, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/W19-0006 SectionsAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Video. Annals Story Slam - A Variation on the Lipstick Sign "A Variation on the Lipstick Sign," by Dr. Maria Maldonado (Duration 6:35)Building on the popular Annals feature “On Being a Doctor,” storytellers share stories about the experience of doctoring on video.For more videos from and information on Annals Story Slam, visit go.annals.org/StorySlam. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: This article was published at Annals.org on 12 April 2019. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 7 May 2019Volume 170, Issue 9Page: SS1 ePublished: 12 April 2019 Issue Published: 7 May 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.Loading ...
Concurrent Targeting of Glutaminolysis and Metabotropic Glutamate Receptor 1 (GRM1) Reduces Glutamate Bioavailability in GRM1+ Melanoma
Authors: Raj Shah, Simar J. Singh, Kevinn Eddy, Fabian V. Filipp, Suzie Chen
Journal: Cancer Research (2019)

Abstract Aberrant glutamatergic signaling has been implicated in altered metabolic activity in many cancer types, including malignant melanoma. Previously, we have illustrated the role of metabotropic glutamate receptor 1 (GRM1) in neoplastic transformation of melanocytes in vitro and spontaneous metastatic melanoma in vivo. In this study, we showed that autocrine stimulation constitutively activates the GRM1 receptor and its downstream mitogenic signaling. GRM1-activated (GRM1+) melanomas exhibited significantly increased expression of glutaminase (GLS), which catalyzes the first step in the conversion of glutamine to glutamate. In cultured GRM1+ melanoma cell lines, CB-839, a potent, selective, and orally bioavailable inhibitor of GLS, suppressed cell proliferation, while riluzole, an inhibitor of glutamate release, promoted apoptotic cell death in vitro and in vivo. Combined treatment with CB-839 and riluzole treatment proved to be superior to single-agent treatment, restricting glutamate bioavailability and leading to effective suppression of tumor cell proliferation in vitro and tumor progression in vivo. Hyperactivation of GRM1 in malignant melanoma is an oncogenic driver, which acts independently of canonical melanoma proto-oncogenes, BRAF or NRAS. Overall, these results indicate that expression of GRM1 promotes a metabolic phenotype that supports increased glutamate production and autocrine glutamatergic signaling, which can be pharmacologically targeted by decreasing glutamate bioavailability and the GLS-dependent glutamine to glutamate conversion. Significance: These findings demonstrate that targeting glutaminolytic glutamate bioavailability is an effective therapeutic strategy for GRM1-activated tumors.
SAT-089-Evaluating the impact of non-selective beta-blocker use in decompensated cirrhosis based on setting of patient care
Authors: Rooshi Nathwani, David Kockerling, Sharmili Balarajah, Roberta Forlano, Nowlan Selvapatt, Pinelopi Manousou, Ameet Dhar
Journal: Journal of Hepatology (2019)
Education as a vehicle towards quality improvement in the European Society of Cardiology
Authors: Paulus Kirchhof, Ronen Beeri, Kevin Fox, Julia Grapsa, Dipak Kotecha
Journal: Cardiovascular Research (2019)

Part of a Cardiovascular Research Onlife series on Commitees of the European Society of Cardiology (ESC).Check back regularly for new articles.The European Society of Cardiology is a leader in the field of cardiology education for trainee cardiologists, certified cardiologists, and other healthcare professionals, as well as developing and promoting standards for their training, continuous education, and professional conduct.The ESC vision in terms of education is to improve cardiovascular outcomes, and the ESC strives to achieve this goal by designing educational programmes that are impactful, providing mechanisms for implementation of clinical practice guidelines, ensuring demonstrable outcomes, and engaging with relevant expertise.
PS-122-Seladelpar for the treatment of primary biliary cholangitis: Experience with 26 cirrhotic patients
Authors: Marlyn J. Mayo, Christopher Bowlus, Galambos Michael, Guy Neff, Palak Trivedi, Aparna Goel, Joseph Odin, Bruce Bacon, Brian Borg, Stuart C Gordon, Aliya Gulamhusein, Stephen Harrison, Cynthia LEVY, Carmen Stanca, John Vierling, Alexandra (Sasha) Steinberg, Monika Varga, Jaidyn Nguyen, Sandrin Bergheanu, Yun-Jung Choi, Mary Standen, Pol Boudes
Journal: Journal of Hepatology (2019)
THU-073-The use of APRI and FIB-4 scores versus transient elastography for the assessment of liver fibrosis stage in patients with chronic hepatitis C: Is it possible to reduce the need for elastography?
Authors: Nikolaos Papadopoulos, Sofia Vasileiadi, Stavroula Michalea, Pinelopi Antonakaki, Maria Papavdi, Erminia Dellaporta, Emmanouel Koullias, Evaggelia Koutli, Spilios Manolakopoulos, Ioannis-Georgios Koskinas, Melanie Deutsch
Journal: Journal of Hepatology (2019)