tbuckley/cabot-search huggingface dataset:
Type-I interferons in atherosclerosis
Authors: Hung-Jen Chen, Sander W. Tas, Menno P.J. de Winther
Journal: The Journal of Experimental Medicine (2019)

The contribution of dyslipidemia and inflammation in atherosclerosis is well established. Along with effective lipid-lowering treatments, the recent success of clinical trials with anti-inflammatory therapies and the accelerated atherosclerosis in many autoimmune diseases suggest that targeting inflammation may open new avenues for the prevention and the treatment for cardiovascular diseases (CVDs). In the past decades, studies have widened the role of type-I interferons (IFNs) in disease, from antivirus defense to autoimmune responses and immuno-metabolic syndromes. While elevated type-I IFN level in serum is associated with CVD incidence in patients with interferonopathies, experimental data have attested that type-I IFNs affect plaque-residing macrophages, potentiate foam cell and extracellular trap formation, induce endothelial dysfunction, alter the phenotypes of dendritic cells and T and B lymphocytes, and lead to exacerbated atherosclerosis outcomes. In this review, we discuss the production and the effects of type-I IFNs in different atherosclerosis-associated cell types from molecular biology studies, animal models, and clinical observations, and the potential of new therapies against type-I IFN signaling for atherosclerosis.
Theranostic nanobubble encapsulating a plasmon-enhanced upconversion hybrid nanosystem for cancer therapy
Authors: Wen-Tse Huang, Ming-Hsien Chan, Xueyuan Chen, Michael Hsiao, Ru-Shi Liu
Journal: Theranostics (2019)

Nanobubble (NB), which simultaneously enhances ultrasound (US) images and access therapeutic platforms, is required for future cancer treatment. Methods: We designed a theranostic agent for novel cancer treatment by using an NB-encapsulated hybrid nanosystem that can be monitored by US and fluorescent imaging and activated by near-infrared (NIR) light. The nanosystem was transported to the tumor through the enhanced permeability and retention effect. The hybrid nanosystem comprised upconversion nanoparticle (UCNP) and mesoporous silica-coated gold nanorod (AuNR@mS) with the photosensitizer merocyanine 540 to realize dual phototherapy. Results: With the NIR light-triggered, the luminous intensity of the UCNP was enhanced by doping holmium ion and emitted visible green and red lights at 540 and 660 nm. The high optical density state between the UCNP and AuNR@mS can induce plasmonic enhancement to improve the photothermal and photodynamic effects, resulting in cell death by apoptosis. The nanosystem showed excellent stability to avoid the aggregation of nanoparticles during the treatment. JC-1 dye was used as an indicator of mitochondrial membrane potential to identify the mechanism of cell death. The results of in vitro and in vivo analyses confirmed the curative effect of improved dual phototherapy. Conclusion: We developed and showed the therapeutic functions of a novel nanosystem with the combination of multiple theranostic nanoplatforms that can be triggered and activated by 808 nm NIR laser and US.
Long acting GLP-1 analog liraglutide ameliorates skeletal muscle atrophy in rodents
Authors: Anagha Ashok Gurjar, Sapana Kushwaha, Sourav Chattopadhyay, Nabanita Das, Subhashis Pal, Shyamsundar Pal China, Harish Kumar, Arun Kumar Trivedi, Rajdeep Guha, Naibedya Chattopadhyay, Sabyasachi Sanyal
Journal: Metabolism (2019)
Suicide Case-Fatality Rates in the United States, 2007 to 2014
Authors: Andrew Conner, Deborah Azrael, Matthew Miller
Journal: Annals of Internal Medicine (2019)

The suicide case-fatality rate (CFR)-the proportion of suicidal acts that are fatal-depends on the distribution of methods used in suicidal acts and the probability of death given a particular method (method-specific CFR).To estimate overall and method-specific suicide CFRs and the distribution of methods used in suicidal acts by demographic characteristics.Cross-sectional study.United States, 2007 to 2014.Suicide deaths (n = 309 377 records from the National Vital Statistics System) and nonfatal suicide attempts requiring treatment in an emergency department (ED) (n = 1 791 638 records from the Nationwide Emergency Department Sample) or hospitalization (n = 1 556 871 records from the National [Nationwide] Inpatient Sample) among persons aged 5 years or older.Rates of suicide deaths and nonfatal suicide attempts, overall and method-specific CFRs, and distribution of methods used, by sex, age group, region, and urbanization.Overall, 8.5% of suicidal acts were fatal (14.7% for males vs. 3.3% for females; 3.4% for persons aged 15 to 24 years vs. 35.4% for those aged ≥65 years). Drug poisoning accounted for 59.4% of acts but only 13.5% of deaths; firearms and hanging accounted for only 8.8% of acts but 75.3% of deaths. Firearms were the most lethal method (89.6% of suicidal acts with a firearm resulted in death), followed by drowning (56.4%) and hanging (52.7%). Method-specific CFRs were higher for males and older persons. The distribution of methods varied across demographic groups.Results are based on suicidal acts resulting in an ED visit, a hospitalization, or death. Consequently, the reported CFRs are larger than they would have been had the data included nonfatal attempts that did not result in an ED visit.Variation in overall suicide CFR between sexes and across age groups, regions, and urbanization is largely explained by the distribution of methods used in suicidal acts.Joyce Foundation.
Polymerase chain reaction - surface-enhanced Raman spectroscopy (PCR-SERS) method for gene methylation level detection in plasma
Authors: Xiaozhou Li, Tianyue Yang, Caesar Siqi Li, Youtao Song, Deli Wang, Lili Jin, Hong Lou, Wei Li
Journal: Theranostics (2019)

Gene promoter hypermethylation is a vital step in tumorigenesis. This paper set out to explore the use of polymerase chain reaction - surface-enhanced Raman spectroscopy (PCR-SERS) for the detection of gene methylation levels, with a focus on cancer diagnosis. Methods: PCR with methylation independent primers were used on DNA samples to amplify target genes regardless of their methylation states. SERS was used on the obtained PCR products to generate spectra that contained peak changes belonging to CG and AT base pairs. Multiple linear regression (MLR) was then used to deconvolute the SERS spectra so that the CG/AT ratios of the sample could be obtained. These MLR results were used to calculate methylation levels of the target genes. For protocol verification, three sets of seven reference DNA solutions with known methylation levels (0%, 1%, 5%, 25%, 50%, 75%, and 100%) were analysed. Clinically, blood plasma samples were taken from 48 non-small-cell lung cancer (NSCLC) patients and 51 healthy controls. The methylation levels of the genes p16, MGMT, and RASSF1 were determined for each patient using this method. Results: Verification experiment on the mixtures with known methylation levels resulted in an error of less than 6% from the actual levels. When applied to our clinical samples, the frequency of methylation in at least one of the three target genes among the NSCLC patients was 87.5%, but this percentage decreased to 11.8% for the control group. The methylation levels of p16 were found to be significantly higher in NSCLC patients with more pack-years smoked (p=0.04), later cancer stages (p=0.03), and cancer types of squamous cell and large cell versus adenocarcinoma (p=0.03). Prediction accuracy of 88% was achieved from classification and regression trees (CART) based on methylation levels and states, respectively. Conclusion: This research showed that the PCR-SERS protocol could quantitatively measure the methylation levels of genes in plasma. The methylation levels of the genes p16, MGMT, and RASSF1 were higher in NSCLC patients than in controls.
Difference in the Donor Selection Priority in Allogeneic Hematopoietic Stem Cell Transplantation According to Patient Age
Authors: Koji Kawamura, Junya Kanda, Sachiko Seo, Fumihiko Kimura, Masahiro Hirayama, Naoyuki Uchida, Noriko Doki, Takahiro Fukuda, Yukiyasu Ozawa, Yuta Katayama, Minoko Takanashi, Yoshiko Atsuta, Yoshinobu Kanda
Journal: Blood (2019)
High-Dose Dexamethasone (HD-DXM) Plus Oseltamivir Versus High-Dose Dexamethasone for Treatment of Adult Primary Immune Thrombocytopenia: Interim Analysis of a Prospective, Multicenter, Randomized, Controlled Trial
Authors: Lu Sun, Xinguang Liu, Hai Zhou, Hongguo Zhao, Chenglu Yuan, Daqi Li, Zhencheng Wang, Yu Hou, Jun Peng, Ming Hou
Journal: Blood (2019)
Liver CT evaluation using a software that automatically generates report according to RECIST 1.1 criteria.
Authors: Flavia Longo, Franco Iafrate, Daniela Adua, Paolo Baldassarri, Gabriella Del Bene, Marco Di Marco, Lucilla De Filippis, Vittoria Lapadula, Paola Gazzaniga, Luigi Frati
Journal: Journal of Clinical Oncology (2012)

e14096 Background: The aim of this retrospective study is to define the usefullness of an integrated CT software that automatically generates report according to RECIST 1.1 criteria and Choi criteria, evaluating the effects of bevacizumab based chemotherapy on CRC liver metastases. Methods: 35 patients with a total of 144 CRC liver metastases underwent CT before and after treatment. Patients with peritoneal disease were excluded. Reporting time was recorded for all patients. CT images were reviewed by two radiologists in consensus, in order to correlate clinical values with CT images using a software (Median, Technologies, France) that automatically synchronizes the images and pairs lesions in repeat CT scans according to RECIST 1.1 criteria as well as lesion density variation using Choi criteria. Results: Reports showed a good correlation between CT images and laboratory values in 31/35 patients during the period of response and in 29/35 during the period of disease progression. The associated use of Choi criteria, evaluating lesion density, provided a better correlation in 33/35 patients during the period of clinical response to therapy and in 31/35 during the period of disease progression. In 6 patients with 21 lesions, lesion density difficulty matches with laboratory values due to the presence of calcifications or to lesion small size. Average reporting time ranged between 16 to 18 minutes. Serum level biomarkers correlates with history disease and circulating tumor cells number using CellSearch system, according to recent literature, always results zero. Conclusions: Using this software we provide accurate quantitative assessment of response to bevacizumab based chemotherapy in liver mCRC with a good correlation between imaging and laboratory values.
Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation
Authors: Mary Speir, Cameron J. Nowell, Alyce A. Chen, Joanne A. O’Donnell, Isaac S. Shamie, Paul R. Lakin, Akshay A. D’Cruz, Roman O. Braun, Jeff J. Babon, Rowena S. Lewis, Meghan Bliss-Moreau, Inbar Shlomovitz, Shu Wang, Louise H. Cengia, Anca I. Stoica, Razq Hakem, Michelle A. Kelliher, Lorraine A. O’Reilly, Heather Patsiouras, Kate E. Lawlor, Edie Weller, Nathan E. Lewis, Andrew W. Roberts, Motti Gerlic, Ben A. Croker
Journal: Nature Immunology (2019)
Reflex control of atrioventricular nodal refractory periods by cardiopulmonary receptors in humans.
Authors: Yukio Nakamura, Kensuke Kaseno, Tadao Ishikawa, Kazuyuki Iuchi
Journal: Circulation (1992)

The effects of selective cardiopulmonary receptor unloading on atrioventricular (AV) conduction were examined in 7 patients undergoing electrophysiologic testing. During -35 mmHg lower body negative pressure (LBNP) before autonomic blockade with propranolol and atropine, the AV-nodal conduction time (AH interval), the effective and functional refractory periods of AV node decreased at paced cycle length, when systemic arterial and central venous pressures decreased and heart rate increased. These responses to -35 mmHg LBNP except reductions in systemic arterial and central venous pressures disappeared after autonomic blockade. During -10 mmHg LBNP before autonomic blockade, both effective and functional refractory periods of AV node at paced cycle length decreased by 11 +/- 3% (mean +/- SEM) and 6 +/- 1% respectively with the reduction of central venous pressure while AH interval, systemic arterial pressure and heart rate remained unchanged. After autonomic blockade, -10 mmHg LBNP reduced central venous pressure but all the other parameters remained unchanged. These results suggest that cardiopulmonary baroreceptors participate in the reflex control of AV nodal refractoriness in humans.
Differentiation and Immunoregulatory Activity of Dental Pulp-Derived Mesenchymal Cells.
Authors: Alberto Grossi, Laura Pierdomenico, Laura Bonsi, Cosetta Marchionni, Francesco Alviano, Valentina Fossati, Ennio Becchetti, Mario Calvitti, Mario Arpinati, Gabriella Chirubolo, Gian Paolo Bagnara, Damiano Rondelli
Journal: Blood (2004)
Presence of Chip-Mutated Autologous Hematopoietic Cells in Mobilized Peripheral Blood Products Is Associated with Shorter Progression-Free Survival after Autologous Transplants for Multiple Myeloma
Authors: Ehsan Malek, Petra Martin, Paolo F Caimi, Benjamin K. Tomlinson, Michael Caldwell, Gayathri Ravi, Sowjanya Vuyyala, Hannah Schmikla, Robert Fox, Marcos de Lima, Navid Sadri, James Driscoll
Journal: Blood (2019)
A Phase 1 Trial of STA-5312, a Microtubule Inhibitor with a Novel Binding Site, in Hematologic and Solid Malignancies.
Authors: Howard Burris, Neil Abramson, Cynthia L. Martel, Lee V. Schwartzberg, William Dooley, Matthew W. McLeod, Thomas Dahl, Matthew Sherman, Steven Limentani
Journal: Blood (2005)
Risk factors for underlying vitamin D deficiency in children with cancer at their diagnosis for cancer.
Authors: Nurdan Tacyildiz, Gulsah Oktay Tanyildiz, Gulsan Yavuz, Emel Unal, Handan Dincaslan, Zulfukar Gordu, Derya Ozyoruk, Derya Gokmen Oztuna, Zeynep Biyikli
Journal: Journal of Clinical Oncology (2013)

10068 Background: There is increasing interest in the possible association between cancer incidence and vitamin D. Our recent study showed a prominent Vit D deficiency in our pediatric cancer patients during their admition. Methods: Seventy newly diagnosed Pediatric cancer patients that have been defined as Vit D deficiency at our clinic, enrolled the study between 2010-2013. A questionare with 32 questiones has been performed to each patient’s family. Questiones are designed to determine risk factors for Vit D deficiency like; daily sun light exposure, consumption of food that known as source of the Vit D, suplementation during pregnancy, lactation and during infancy,etc.SPSS 11.5 program used for istatistical analyses Results: This study has been designed as a questionare based research to find out possible risk factors for Vit D deficiency in our patients. Seventy patients with leukemias , lymphomas and solid tumors were included in the study. Fourtysix boys (66%) and 24 girls ( 34%) were between 2 months to 18 years old (median: 9 years). Almost 60 % of the patients have been borned during autumn or winter. Education level : 8 % of the fathers and 19 % of the mothers were not received any education at school. During pregnancy 64% and during lactation 83% of the mothers have not been supplemented with Vit D. Seventy four percent of the mothers did not have any knowledge about importance of the Vit D. Supplementation of the Vit D during infancy was not avaliable for 58% of the patients. Daily exposure to the sun light was between 0 to 6 hours (median:2.2 hours/day). Monthly consumption of fish and egg was between 0 to 5 times (median: 1.3 time/month) for fish and between 0 to 45 eggs (median 13.9 eggs/ month ) respectively. Daily consumption of the milk was between 0 to 2 glases (median: 1 glass/day) . Conclusions: Famillies are not aware of the importance of Vit D. Consumption of Vit D containing foods are much lover than recomended nutrition facts.A special attention has to be given for education of parents for vit D supplementation during pregnancy, lactation and infancy. Besides, it should be started to educate peopele beginning from their childhood to have enough daily sun light exposure and Vit D containing foods as a part of their healthy life style.
Parietal Pleura-Based Malignant Perivascular Epithelioid Cell Neoplasm Protruding Into Serous Cavity: A Hitherto Unrecognized Occurrence
Authors: Giuseppe Pelosi, Giovanna Sabella, Maria Cannone, Emanuela Balladore, Nikolaos Papanikolaou, Matteo Incarbone, Maurizio Zompatori, Sergio Harari, Amedeo Vittorio Bedini
Journal: Journal of Thoracic Oncology (2019)
Gender Differences in Iron Overload and Left Ventricular Function in a Cohort of Thalassemia Major Patients: A Prospective Study of a Single Italian Center Using Cardiovascular Magnetic Resonance.
Authors: Elisabetta Volpato, Elena Cassinerio, Maria Rosaria Fasulo, Paola Pedrotti, Stefano Pedretti, Santo Dellegrottaglie, Maria Domenica Cappellini, Alberto Roghi
Journal: Blood (2007)
Association of Dietary Patterns in Midlife and Cognitive Function in Later Life in US Adults Without Dementia
Authors: Jennifer L. Dearborn-Tomazos, Aozhou Wu, Lyn M. Steffen, Cheryl A. M. Anderson, Emily A. Hu, David Knopman, Thomas H. Mosley, Rebecca F. Gottesman
Journal: JAMA Network Open (2019)

<h3>Importance</h3> The association of dietary patterns, or the combinations of different foods that people eat, with cognitive change and dementia is unclear. <h3>Objective</h3> To examine the association of dietary patterns in midlife with cognitive function in later life in a US population without dementia. <h3>Design, Setting, and Participants</h3> Observational cohort study with analysis of data collected from 1987 to 2017. Analysis was completed in January to February 2019. Community-dwelling black and white men and women from Washington County, Maryland; Forsyth County, North Carolina; Jackson, Mississippi; and suburban Minneapolis, Minnesota, participating in the Atherosclerosis Risk in Communities (ARIC) study were included. <h3>Exposures</h3> Two dietary pattern scores were derived from a 66-item food frequency questionnaire using principal component analysis. A Western, or unhealthy, dietary pattern was characterized by higher consumption of meats and fried foods. A so-called prudent, or healthier, dietary pattern was characterized by higher amounts of fruits and vegetables. <h3>Main Outcomes and Measures</h3> Results of 3 cognitive tests (Digit Symbol Substitution Test, Word Fluency Test, and Delayed Word Recall) performed at 3 points (1990-1992, 1996-1998, and 2011-2013) were standardized and combined to represent global cognitive function. The 20-year change in cognitive function was determined by tertile of diet pattern score using mixed-effect models. The risk of incident dementia was also determined by tertile of the diet pattern score. <h3>Results</h3> A total of 13 588 participants (7588 [55.8%] women) with a mean (SD) age of 54.6 (5.7) years at baseline were included; participants in the top third of Western and prudent diet pattern scores were considered adherent to the respective diet. Cognitive scores at baseline were lower in participants with a Western diet (<i>z</i>score for tertile 3 [T3], −0.17 [95% CI, −0.20 to −0.14] vs T1, 0.17 [95% CI, 0.14-0.20]) and higher in participants with a prudent diet (<i>z</i>score for T3, −0.09 [95% CI, −0.12 to −0.06] vs T1, −0.09 [95% −0.12 to −0.06]). Estimated 20-year change in global cognitive function did not differ by dietary pattern (difference of change in<i>z</i>score for Western diet, T3 vs T1: −0.01 [95% CI, −0.05 to 0.04]; and difference of change in<i>z</i>score for prudent diet, T3 vs T1: 0.02 [95% CI, −0.02 to 0.06]). The risk of incident dementia did not differ by dietary pattern (Western hazard ratio for T3 vs T1, 1.06 [95% CI, 0.92-1.22]; prudent hazard ratio for T3 vs T1, 0.99 [95% CI, 0.88-1.12]). <h3>Conclusions and Relevance</h3> This study found that the dietary pattern of US adults at midlife was not associated with processing speed, word fluency, memory, or incident dementia in later life.
Subdivision of M1 Stage for De Novo Metastatic Breast Cancer to Better Predict Prognosis and Response to Primary Tumor Surgery
Authors: Caijin Lin, Jiayi Wu, Shuning Ding, Chihwan Goh, Lisa Andriani, Shuangshuang Lu, Kunwei Shen, Li Zhu
Journal: Journal of the National Comprehensive Cancer Network (2019)

Patients with de novo metastatic breast cancer (MBC) constitute a heterogeneous group with different clinicopathologic characteristics and survival outcomes. Despite controversy regarding its prognostic value, primary tumor surgery may improve survival for selected patients.Patients with de novo MBC were identified using the SEER database and were then divided randomly into training and validation sets. A Fine-Gray competing risks model was developed to identify the variables associated with increased cancer-specific mortality in the training set. The M1 subdivision system was established based on the independent prognostic factors. Cumulative incidence curves were estimated and compared using Gray's test.Involvement of brain or liver and number of metastatic sites were identified as independent prognostic factors in multivariate analysis. The M1 category was subdivided into 3 subcategories: M1a, single site involvement except brain and liver; M1b, liver involvement only, or multiple site involvement except brain and liver; and M1c, brain involvement regardless of number of metastatic sites, or liver and other sites involvement except brain (M1b vs M1a: subdistribution hazard ratio [SHR], 1.48; 95% CI, 1.29-1.68; M1c vs M1a: SHR, 2.45; 95% CI, 2.18-2.75). Patients with the M1a subtype benefited most from primary tumor surgery in the adjusted competing risks model (M1a: SHR, 0.57; 95% CI, 0.48-0.67, M1b: SHR, 0.62; 95% CI, 0.47-0.83, and M1c: SHR, 0.59; 95% CI, 0.44-0.80), whereas benefits conferred by treatment with chemotherapy alone increased with the upstaging of metastatic disease (M1a: SHR, 0.72; 95% CI, 0.62-0.83, M1b: SHR, 0.54; 95% CI, 0.44-0.68, and M1c: SHR, 0.53; 95% CI, 0.45-0.61).Subdivision of M1 stage facilitates prognosis prediction and treatment planning for patients with de novo MBC. Treatment offered should be decided in a coordinated multidisciplinary setting. Primary tumor surgery may play an important role in the management of selected patients.
VIROLOGIC STUDIES IN RHEUMATOID ARTHRITIS AND OTHER CONNECTIVE TISSUE DISEASES
Authors: Paul E. Phillips
Journal: The Journal of Experimental Medicine (1971)

A total of 187 specimens from 142 subjects with rheumatoid arthritis, systemic lupus erythematosus, other connective tissue diseases, and controls were placed in cell culture. Specimens from 119 of the subjects grew, lasting over 2 yr in several instances. No evidence of virus infection has been found by a variety of sensitive methods, including cell fusion. Other approaches have likewise failed thus far to implicate any virus in the pathogenesis of rheumatoid arthritis.
Hematopoietic Recovery and Overall Survival after HLA-Matched Sibling Transplants for Older Patients with Severe Aplastic Anemia (SAA).
Authors: Vikas Gupta, Jeanette Carreras, Ruta Bajorunaite, Robert Peter Gale, Mitchell Sabloff, Mahmoud Aljurf, Hubert Schrezenmeier, Gerard Socié, Jakob Passweg, Olle Ringdén, Ricardo Pasquini, Judith Marsh, Mary Eapen
Journal: Blood (2008)