tbuckley/cabot-search huggingface dataset:
AB0745 Mechanics of early ventricular impairment in systemic sclerosis and the effects of peripheral vasculopathy
Authors: C. Tountas, V.-K. Bournia, S. Panopoulos, A. Gournizakis, D. Beldekos, M.G. Tektonidou, A.D. Protogerou, P.P. Sfikakis
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Multiple mechanisms commonly lead to severe cardiac involvement in systemic sclerosis (SSc), an autoimmune disease characterised by microvascular lesions, systemic inflammation and fibrosis. <h3>Objectives</h3> To examine the mechanics of right and left ventricles (RV, LV) at the early stage of possible impairment and test the hypothesis that peripheral arterial hemodynamics are associated with an early LV compromise. <h3>Methods</h3> Ninety-five asymptomatic SSc patients free of cardiovascular disease (88% women, 53±14 years) and 54 apparently healthy controls matched for age, gender, arterial hypertension, dyslipidaemia, and diabetes mellitus underwent echocardiography, including multilayer speckle-tracking, and tonometry-based pulse wave analysis of the peripheral arteries; 66 SSc patients were prospectively assessed after 32±7 months. Indices of ventricular and arterial structure and function, as well as LV-arterial coupling, were calculated. <h3>Results</h3> At baseline, patients presented RV diastolic/systolic impairment, as well as LV remodelling and diastolic/systolic impairment in terms of reduced deformation parameters versus controls. No association was evident between RV and LV strain within individual patients, whereas by multivariate analysis including age, gender and SSc characteristics we found that the global longitudinal strain of RV free wall was associated only with the presence of diffuse skin involvement (b=2.63, p=0.042) and both global longitudinal and circumferential strain of LV were correlated only with disease duration (b=0.14, p=0.001 and b=0.17, p=0.032, respectively). Both RV and LV abnormalities progressed independently during follow-up. Moreover, in the absence of differences in aortic stiffening and LV-arterial coupling between patients and controls, arterial pressure wave reflections assessing small vessel function and/or microcirculation were abnormal in SSc patients and strongly correlated with impaired indices of LV diastolic function and remodelling. <h3>Conclusions</h3> These novel findings show the mechanics of RV early impairment in SSc that develops and progresses independently from the concomitant LV impairment, which, in turn, may be influenced by peripheral microvascular abnormalities in the absence of macrovascular damage. <h3>Disclosure of Interest</h3> None declared
Musashi 2 Is Overexpressed in Poor Outcome CLL Patients and Their Proliferative Fraction and Silencing This Gene Induces Apoptosis and Increases Cell Adhesion and Movement
Authors: Florencia Palacios, Xiao-Jie Yan, Gerardo Ferrer, Jacqueline C Barrientos, Jonathan E. Kolitz, Steven L. Allen, Rai Kanti R., Nicholas Chiorazzi
Journal: Blood (2018)
RBC-Specific CD47 Pruning Confers Protection and Underlies the Transient Anemia in Patients Treated with Anti-CD47 Antibody 5F9
Authors: James Y Chen, Kelly Marie McKenna, Timothy S Choi, Jiaqi Duan, Lynette Brown, Jennifer J Stewart, Kavitha Sompalli, Paresh Vyas, Stanley Schrier, Ravindra Majeti, Irving L Weissman, Kyle Elrod, Mark Ping Chao, Chris H Takimoto, Jie Liu, Jens-Peter Volkmer
Journal: Blood (2018)
Behavior is sensible but not globally optimal: Seeking common ground in the optimality debate
Authors: Dobromir Rahnev, Rachel N Denison
Journal: Behavioral and Brain Sciences (2018)

Abstract The disagreements among commentators may appear substantial, but much of the debate seems to stem from inconsistent use of the term optimality . Optimality can be used to indicate sensible behavior (adapted to the environment), globally optimal behavior (fully predicted from optimality considerations alone), locally optimal behavior (conforming to a specific model), and optimality as an empirical strategy (a tool for studying behavior). Distinguishing among these different concepts uncovers considerable common ground in the optimality debate.
SAT0504 The association of myositis specific antibodies in patients with inflammatory myositis: preliminary data in indian patients
Authors: N.V. Negalur, D. Raval, M. Bindroo, W. Kazi, U. Baveja, R. Gupta
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Studies in Autoimmune Inflammatory Myositis (AIM) have shown that certain antibodies have a role in the diagnosis and prognosis of patients with myositis. This ongoing study presents the preliminary data of 48 patients of Indian AIM. <h3>Objectives</h3> To study the prevalence of Myositis specific and Myositis Associated antibodies (MSA and MAA respectively) in Indian patients with AIM and to correlate these antibodies with clinical features. <h3>Methods</h3> All consecutive patients with Inflammatory myositis (satisfying the Bohan and Peter criteria, 1975 attending the Rheumatology and Clinical Immunology department of Medanta hospital from November 2016 to October 2017 were included prospectively and divided into groups as Dermatomyositis (DM), Polymyositis (PM), CTD associated myositis (CTD-M), Cancer associated myositis (CAM) and Juvenile Myositis (JM). Their clinical data and sera were collected after obtaining informed consent. Sera was analysed for IgG antibodies against Jo-1, PL-7, PL-12, EJ, SRP, Mi-2, MDA-5, TIF1γ, SAE1, SAE2, NXP2 and SSA/R052kD using the microELISA technique (BlueDriver Dot Myositis<sup>12</sup> SAE IgG kit). Their ENA was also recorded (Blue DriverQuantrix-ANA25 Screen IgG kit d-tek). Results were read by the BlueScan scanner and value ≥10 were considered positive. The study was approved by the Ethics committee of Medanta hospital. <h3>Results</h3> There were 48 patients in the cohort (M:F=12:36) with the mean age of 41.3 years and a median disease duration of 30 months. Nineteen of them were DM, 19 were PM, 5 were CTD-M, 2 were CAM and 3 were JM. 58.3% were ANA positive and MSA were positive in 37.5% of the cohort, MSA being mutually exclusive. Antibodies against Mi-2 were present in 6 patients (12.5%), Jo-1 antibodies in 5 (10.4%), 2 (4.1%) patients each had PL-7 and SRP antibodies. One patient (2%) each had MDA-5, NXP2 and TIf1γ antibodies. MAAs were seen in 39.5% of the cohort with antibodies against Ro, RNP and PM- Scl seen in 16 (33.3%), 2 (4.1%) and 1 (2%) respectively. Mi-2 antibodies were seen only in DM and JM group. The lone patient who had MDA-5 antibody had amyopathic DM. Malignancy screening was negative in NXP2 and TIF1γ antibody positive patients. <h3>Conclusions</h3> MSA were present in almost 40% of the cohort. Mi-2 antibodies were associated with rash and none had ILD whereas Jo-1 antibodies were associated with mechanic hands, arthritis and ILD. With further recruitment of patients in this ongoing study, we hope to get more robust data in future. <h3>Disclosure of Interest</h3> None declared
Performance of human papillomavirus testing on self-collected versus clinician-collected samples for the detection of cervical intraepithelial neoplasia of grade 2 or worse: a randomised, paired screen-positive, non-inferiority trial
Authors: Nicole J Polman, Renée M F Ebisch, Daniëlle A M Heideman, Willem J G Melchers, Ruud L M Bekkers, Anco C Molijn, Chris J L M Meijer, Wim G V Quint, Peter J F Snijders, Leon F A G Massuger, Folkert J van Kemenade, Johannes Berkhof
Journal: The Lancet Oncology (2019)
Feasibility of the peroral endoscopic myotomy (POEM) procedure with a new small-caliber endoscope (thin-POEM) in patients with achalasia
Authors: Oscar Hernandez Mondragón, Marina González Martínez, Omar Solórzano Pineda, Juan Blancas Valencia, María Hernández Reyes
Journal: Endoscopy (2019)

Abstract Background Peroral endoscopic myotomy (POEM) is a recognized technique for patients with achalasia. We aimed to evaluate the feasibility of using a small-caliber endoscope (thin-POEM) to perform POEM in patients with achalasia. Methods Naïve or previously treated patients were included between February 2016 and April 2018. A small-caliber (5.9 mm) nasoendoscope was used, with a modified closure method using cyanoacrylate. Strict follow-up was performed. Results 45 patients were included, aged 45.5 years (interquartile range [IQR] 22 – 69); 53 % (24/45) had type II achalasia. Median total time for thin-POEM was 54 minutes (IQR 37 – 77) and median myotomy length was 13.5 cm (IQR 6 – 20). Results pre-procedure and 3 months post were Eckardt score 10 vs. 1 (P &lt; 0.001), integrated relaxation pressure (IRP) 25.3 vs. 8.5 mmHg (P &lt; 0.001), and timed barium esophagram (TBE) 100 % severely delayed vs. 86 % normal (P &lt; 0.001), respectively. Type III patients had the longest thin-POEM times (median 58 minutes [IQR 52 – 77]). Reflux was confirmed at 3 months clinically in 17 % of patients, endoscopically in 20 %, and on pH monitoring in 53 %. At 6 months and 12 months, 40 % and 33 % of patients remained positive on pH monitoring and were medically managed. Conclusions Thin-POEM seems to be a safe, effective, and efficient procedure for POEM in patients with achalasia, with good short-term follow-up results.
Abstract 13482: Hydrogen Sulfide Stimulates Ischemic Vascular Remodeling Through Xanthine Oxidase Dependent Nitrite Reduction Activity Stimulating cGMP, HIF-1 And VEGF Mediated Angiogenesis
Authors: Shyamal Bir, Gopi Krisna Kolluru, Xinggui Shen, Christopher B Pattillo, Christopher G Kevil
Journal: Circulation (2012)

Shyamal Bir, 2012 Finalist and Presenting Author
THU0156 Depression ameliorated by orthopaedic surgical intervention in patients with rheumatoid arthritis
Authors: H. Ishikawa, A. Abe, T. Kojima, M. Kojima, N. Ishiguro, S. Ito, A. Murasawa
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Depression is the most frequently seen comorbidity in the patients with rheumatoid arthritis (RA) <sup>1)</sup>. Inflammatory mediators, including TNF-α, interleukin-1 and interleukin-6, affect serotonin transporters in the brain and promote low stress tolerance and depression <sup>2)</sup>. <h3>Objectives</h3> To investigate the effect of orthopaedic surgery on the mental condition of patients with RA by assessing the Beck depression inventory II (BDI-II) and to investigate the factors associated with changes in the BDI-II. <h3>Methods</h3> A prospective cohort study was performed in 294 sites of primary elective surgery in 276 patients with structural damage due to RA. The average (range) age was 64<sup>19–89</sup> years old, and the average (range) disease duration was 16<sup>1–60</sup> years. The surgical site was the shoulder in 6 patients, elbow in 26, wrist in 74, hand in 63 (with wrist in 18), hip in 13, knee in 50, ankle in 12, and forefoot in 50. The BDI-II, EuroQol 5 dimensions (EQ-5D), Japanese version of the Stanford Health Assessment Questionnaire (J-HAQ), and disease activity score 28 using C-reactive protein<sup>4</sup> (DAS28-CRP<sup>4</sup>) were assessed at the baseline and at 12 months after surgery. During the observational period, the number of patients using methotrexate (MTX), prednisolone (PSL), and biological disease-modifying anti-rheumatic drugs (bDMARDs) did not change significantly. The mean dose of MTX and PSL was reduced by 0.4 mg/w and 0.2 mg/d, respectively, at 12 months after surgery. <h3>Results</h3> In total, the mean BDI-II significantly improved from 13.0 to 11.5 at 12 months after surgery (p&lt;0.01). The number of patients with depression (BDI-II ≥14) decreased from 42.8% to 34.8% (figure 1). A significant improvement in the BDI-II was noted in the elbow, wrist, hand, and forefoot surgeries (p&lt;0.05). EQ-5D, J-HAQ, and DAS28-CRP<sup>4</sup> also improved significantly (p&lt;0.01) <sup>3)</sup>. A multiple regression analysis showed that the magnitude of decrease in the BDI-II (ΔBDI-II) was independently related to the Steinbrocker's stage (95% confidence interval [CI]: 0.42, 2.39, p=0.005) and pain-visual analogue scale (VAS) (95% CI: 0.01, 0.10, p=0.02) at baseline and inversely related to matrix metalloprotainase-3 (MMP-3) (95% CI: −0.01,–0.001, p=0.03) at baseline. The BDI-II was correlated with the EQ-5D (γ=−0.049, p&lt;0.01) and J-HAQ (γ=0.387, p&lt;0.01) at 12 months after surgery. <h3>Conclusions</h3> Depression was ameliorated by surgical intervention in patients with RA. The mental condition is associated with the quality of life and physical function. <h3>References</h3> [1] Dougados M, et al. Ann Rheum Dis2014;73:62–8. [2] Mclnnes IB, Schett G. N Engl J Med2011;365:2205–19. [3] Ishikawa H. Orthop Sci. 2017;22:583–92. <h3>Disclosure of Interest</h3> None declared
Integrative Analysis Defines Distinct Prognostic Subgroups of Intrahepatic Cholangiocarcinoma
Authors: Benjamin Goeppert, Reka Toth, Stephan Singer, Thomas Albrecht, Daniel B. Lipka, Pavlo Lutsik, David Brocks, Marion Baehr, Oliver Muecke, Yassen Assenov, Lei Gu, Volker Endris, Albrecht Stenzinger, Arianeb Mehrabi, Peter Schirmacher, Christoph Plass, Dieter Weichenhan, Stephanie Roessler
Journal: Hepatology (2019)

Intrahepatic cholangiocarcinoma (iCCA) is the second most common primary liver cancer. It is defined by cholangiocytic differentiation and has poor prognosis. Recently, epigenetic processes have been shown to play an important role in cholangiocarcinogenesis. We performed an integrative analysis on 52 iCCAs using both genetic and epigenetic data with a specific focus on DNA methylation components. We found recurrent isocitrate dehydrogenase 1 (IDH1) and IDH2 (28%) gene mutations, recurrent arm‐length copy number alterations (CNAs), and focal alterations such as deletion of 3p21 or amplification of 12q15, which affect BRCA1 Associated Protein 1, polybromo 1, and mouse double minute 2 homolog. DNA methylome analysis revealed excessive hypermethylation of iCCA, affecting primarily the bivalent genomic regions marked with both active and repressive histone modifications. Integrative clustering of genetic and epigenetic data identified four iCCA subgroups with prognostic relevance further designated as IDH, high (H), medium (M), and low (L) alteration groups. The IDH group consisted of all samples with IDH1 or IDH2 mutations and showed, together with the H group, a highly disrupted genome, characterized by frequent deletions of chromosome arms 3p and 6q. Both groups showed excessive hypermethylation with distinct patterns. The M group showed intermediate characteristics regarding both genetic and epigenetic marks, whereas the L group exhibited few methylation changes and mutations and a lack of CNAs. Methylation‐based latent component analysis of cell‐type composition identified differences among these four groups. Prognosis of the H and M groups was significantly worse than that of the L group. Conclusion: Using an integrative genomic and epigenomic analysis approach, we identified four major iCCA subgroups with widespread genomic and epigenomic differences and prognostic implications. Furthermore, our data suggest differences in the cell‐of‐origin of the iCCA subtypes.
AB0896 Association of iga antibodies against cd74 with production of il17a but not of tnfalpha in patients with active axial spondyloarthritis
Authors: X. Baraliakos, K. Kniesch, N. Baerlecken, J. Braun, T. Witte
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Axial spondyloarthritis (axSpA) is strongly associated with HLA-B27. Recently, IgA antibodies (Abs) against CD74 (IgA-anti-CD74) and T-cells carrying CD-74-specific T-cell receptors were also found to be associated with axSpA, especially in patients with ankylosing spondylitis, the radiographic form of axSpA. Tumour necrosis alpha (TNFα) inhibitors and IL-17 antagonists are efficacious in patients with active axSpA. <h3>Objectives</h3> To investigate whether IgA-anti-CD74 Abs are associated with pro-inflammatory cytokines in the sera of patients with HLA-B27-positive and -negative patients with active axSpA. <h3>Methods</h3> Blood samples of 62 HLA-B27-positive and 58 HLA-B27-negative patients with axSpA (44% AS) prior to starting a biologic therapy were collected. A cytometric bead-array (CBA Flex Set) was used to measure serum levels of interleukin (IL)−17A, IL-6, IL-1α, TNFα, and interferon (INF)-γ. IgA-anti-CD74 Abs were measured by ELISA, using the predefined cut-off of 15 U/ml. Their mean concentrations were compared between groups using T-tests. The patients who were positive or negative for IgA-anti-CD74 Abs were compared using chi-square test. <h3>Results</h3> IgA-anti-CD74 Abs were detected in 54/120 axSpA patients (45%). There were no differences in the baseline demographics and clinical assessments in patients with or without IgA-anti-CD74 Abs. The presence of IgA-anti-CD74 Abs was associated with higher serum concentrations of IL-17A (p=0.01), irrespective of the presence of HLA-B27, CRP and IL-6 (both p&lt;0.05) but not TNFa (p=0.2). <h3>Conclusions</h3> In a cross-sectional study, the presence of IgA Abs against CD74 was associated with serum levels of pro-inflammatory biomarkers such as CRP (and IL-6) and IL-17 but not TNFa irrespective of HLA-B27 status. Longitudinal prospective studies are needed to show that the measurement of IgA anti-CD74 Abs and/or serum cytokines can help to guide treatment decisions. <h3>Acknowledgements</h3> We thank Novartis Pharma AG for the support of our study. <h3>Disclosure of Interest</h3> X. Baraliakos: None declared, K. Kniesch: None declared, N. Baerlecken: None declared, J. Braun: None declared, T. Witte Grant/research support from: Novartis
Impact of endoscopy system, high definition, and virtual chromoendoscopy in daily routine colonoscopy: a randomized trial
Authors: Philip Roelandt, Ingrid Demedts, Hilde Willekens, Talat Bessissow, Lieve Braeye, Georges Coremans, Pieter-Jan Cuyle, Marc Ferrante, Anne-Marie Gevers, Martin Hiele, Maggy Osselaer, Jan Tack, Sabine Tejpar, Marijke Ulenaers, Gert Van Assche, Eric Van Cutsem, Stijn Van Gool, Jaarke Vannoote, Severine Vermeire, Raf Bisschops
Journal: Endoscopy (2019)

Abstract Background To improve detection of mucosal lesions during colonoscopy a number of imaging modalities have been suggested, including high definition and virtual chromoendoscopy. Given the theoretical advantage of these new imaging techniques, we aimed to investigate their use for the detection of polyps in patients referred for colonoscopy in a large tertiary hospital. Methods Demographic, endoscopic, and histological data from 1855 consecutive patients undergoing colonoscopy were collected prospectively. Patients were randomly assigned to three endoscopy systems (Fujinon, Olympus, or Pentax) in combination with four modalities: conventional white-light colonoscopy (n = 505), high definition white-light colonoscopy (n = 582), virtual chromoendoscopy (n = 285) and high definition virtual chromoendoscopy (n = 483). Results The mean adenoma detection rate (ADR) was 34.9 %, and the adenoma per colonoscopy rate (APCR) was 2.1. No significant differences were noted between the three endoscopy systems. Moreover, no differences in ADR or APCR were observed between the four imaging modalities. High definition white-light colonoscopy resulted in a significantly higher detection of sessile serrated adenomas (8.2 % vs. 3.8 %; P &lt; 0.01) and adenocarcinomas (2.6 % vs. 0.5 %; P &lt; 0.05) compared with the conventional procedure. Conclusions No significant differences in ADR or APCR between different endoscopy systems, high definition, and/or virtual chromoendoscopy could be observed in routine colonoscopies in the general population. High definition endoscopy was associated with a significantly higher detection rate of serrated adenomas and adenocarcinomas.
Isavuconazole (ISAV) As Primary Anti-Fungal Prophylaxis in Acute Myeloid Leukemia or Myelodysplastic Syndrome: An Open-Label, Prospective Study
Authors: Prithviraj Bose, David McCue, Nathan P. Wiederhold, Tapan M. Kadia, Gautam Borthakur, Farhad Ravandi, Musa Yilmaz, Koichi Takahashi, Philip A. Thompson, Naveen Pemmaraju, Naval G. Daver, Jan A. Burger, Jorge E. Cortes, Guillermo Garcia-Manero, Srdan Verstovsek, Marina Y. Konopleva, Nitin Jain, Courtney D. DiNardo, Yesid Alvarado, Kiran Naqvi, Steven M. Kornblau, Alessandra Ferrajoli, William G. Wierda, Zeev E. Estrov, Christopher B. Benton, Lucia Masarova, Guillermo Montalban-Bravo, Koji Sasaki, Caitlin R. Rausch, Kayleigh Marx, Wei Qiao, Xuelin Huang, Carol A. Bivins, Sherry A. Pierce, Hagop M. Kantarjian, Dimitrios P. Kontoyiannis
Journal: Blood (2018)
Medically Ill Patients with Moderate Renal Insufficiency Have More Thrombotic and Bleeding Events Than Those with Normal Renal Function: Insights from the Magellan and Mariner Trials of Extended Thrombprophylaxis
Authors: Jeffrey I. Weitz, Gary E. Raskob, Alex C. Spyropoulos, Alexander T Cohen, Theodore E. Spiro, Yoriko De Sanctis, Jianfeng Xu, Eunyoung Suh, Wentao Lu, Concetta Lipardi, Elliot S. Barnathan
Journal: Blood (2018)
Abstract 16211: Fraction of Human Mercaptalbumin May Serve as a Novel Biomarker for Patients With Underwent Cardiovascular Surgery
Authors: Takuji Adachi, Hironobu Ashikawa, Jun Ueyama, Ken-ichi Shibata, Hideki Kitamura, Mariko Ehara, Sumio Yamada
Journal: Circulation (2017)

Introduction: Human serum albumin is divided into two forms according to the redox state of the Cys-34; human mercaptalbumin (HMA, reduced albumin) and human nonmercaptalbumin (HNA, oxidized albumi...
OP0222-HPR Physical capacity contributes marginally in explaining variations of fatigue in persons moderately affected by rheumatoid arthritis
Authors: S Pettersson, I. Demmelmaier, B. Nordgren, A.B. Dufour, C.H. Opava
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Fatigue is a prominent problem for persons with rheumatoid arthritis (RA). Physical activity, including planned and structured exercise, is an important non-pharmacological intervention that positively affects fatigue. Physical capacity including variables as aerobic capacity, muscle strength and lower limb capacity, are modifiable and their relative contributions to fatigue are thus of interest to better understand and address this detrimental consequence of RA. <h3>Objectives</h3> To explore the contributions of physical capacity in explaining variations in fatigue among people wth rheumatoid arthritis (RA). <h3>Methods</h3> This cross-sectional study included 269 participants (82% women, mean age 60 years, mean DAS28 2.8, mean HAQ-DI 0.5) recruited for a physical activity intervention. Data were collected from the Swedish Rheumatology Quality Registers, from questionnaires on fatigue, activity limitation, perceived health, pain and anxiety/depression and from physical capacity tests (lower limb function, grip strength, aerobic capacity). We used logistic regression to estimate the association between severe fatigue (≥50, VAS 0–100) and A) independent variables related to disease and disease impact and B) model A plus physical capacity tests. Pooled odds ratio tests compared model fit. <h3>Results</h3> Severe fatigue was reported by 95 participants (35%). The three variables which were statistically significantly associated with severe fatigue (p&lt;0.05) in both models were perceived health, pain and anxiety/depression. Anxiety/depression demonstrated the largest effect size with odds ratios of 2.43 (95% CI: 1.20 to 4.94) in model A and 2.58 (95% CI: 1.25 to 5.32) in model B. The likelihood ratio test indicated that model B was a better fit to the data than model A with <i>χ</i><sup>2</sup> (df 3)=2.65, p=0.048. <h3>Conclusions</h3> We found that disease impact variables rather than physical capacity variables are predictors of severe fatigue in people with RA. Further studies are needed to assess correlations between physical capacity and fatigue using multidimensional assessments of fatigue to enable separate analyses of physical and mental fatigue respectively. <h3>Disclosure of Interest</h3> None declared