tbuckley/cabot-search huggingface dataset:
NOTCH1 Signaling Is Activated in CLL By Mutations of FBXW7 and Low Expression of USP28 at 11q23
Authors: Viola Close, William Close, Sabrina Julia Kugler, Michaela Reichenzeller, Deyan Yordanov Yosifov, Johannes Bloehdorn, Leiling Pan, Eugen Tausch, Mike-Andrew Westhoff, Hartmut Döhner, Stephan Stilgenbauer, Franz Oswald, Daniel Mertens
Journal: Blood (2018)
Eltrombopag treatment during induction chemotherapy for acute myeloid leukaemia: a randomised, double-blind, phase 2 study
Authors: Noelle Frey, Jun Ho Jang, Jeff Szer, Árpád Illés, Hee-Je Kim, Ron Ram, Beng H Chong, Jacob M Rowe, Elena Borisenkova, Jane Liesveld, Eric S Winer, Azzeddine Cherfi, Vassilios Aslanis, Farhat Ghaznawi, Stephen Strickland
Journal: The Lancet Haematology (2019)
Evaluation of Microvascular Injury in Revascularized Patients With ST-Segment–Elevation Myocardial Infarction Treated With Ticagrelor Versus Prasugrel
Authors: Maarten A.H. van Leeuwen, Nina W. van der Hoeven, Gladys N. Janssens, Henk Everaars, Alexander Nap, Jorrit S. Lemkes, Guus A. de Waard, Peter M. van de Ven, Albert C. van Rossum, Tim J.F. ten Cate, Jan J. Piek, Clemens von Birgelen, Javier Escaned, Marco Valgimigli, Roberto Diletti, Niels P. Riksen, Nicolas M. van Mieghem, Robin Nijveldt, Niels van Royen
Journal: Circulation (2019)

Background: Despite successful restoration of epicardial vessel patency with primary percutaneous coronary intervention, coronary microvascular injury occurs in a large proportion of patients with ST-segment–elevation myocardial infarction, adversely affecting clinical and functional outcome. Ticagrelor has been reported to increase plasma adenosine levels, which might have a protective effect on the microcirculation. We investigated whether ticagrelor maintenance therapy after revascularized ST-segment–elevation myocardial infarction is associated with less coronary microvascular injury compared to prasugrel maintenance therapy. Methods: A total of 110 patients with ST-segment–elevation myocardial infarction received a loading dose of ticagrelor and were randomized to maintenance therapy of ticagrelor (n=56) or prasugrel (n=54) after primary percutaneous coronary intervention. The primary outcome was coronary microvascular injury at 1 month, as determined with the index of microcirculatory resistance in the infarct-related artery. Cardiovascular magnetic resonance imaging was performed during the acute phase and at 1 month. Results: The primary outcome of index of microcirculatory resistance was not superior in ticagrelor- or prasugrel-treated patients (ticagrelor, 21 [interquartile range, 15–39] U; prasugrel, 18 [interquartile range, 11–29] U; P =0.08). Recovery of microcirculatory resistance over time was not better in patients with ticagrelor versus prasugrel (ticagrelor, −13.9 U; prasugrel, −13.5 U; P =0.96). Intramyocardial hemorrhage was observed less frequently in patients receiving ticagrelor (23% versus 43%; P =0.04). At 1 month, no difference in infarct size was observed (ticagrelor, 7.6 [interquartile range, 3.7–14.4] g, prasugrel 9.9 [interquartile range, 5.7–16.6] g; P =0.17). The occurrence of microvascular obstruction was not different in patients on ticagrelor (28%) or prasugrel (41%; P =0.35). Plasma adenosine concentrations were not different during the index procedure and during maintenance therapy with ticagrelor or prasugrel. Conclusions: In patients with ST-segment–elevation myocardial infarction, ticagrelor maintenance therapy was not superior to prasugrel in preventing coronary microvascular injury in the infarct-related territory as assessed by the index of microcirculatory resistance, and this resulted in a comparable infarct size at 1 month. Clinical Trial Registration: URL: https://www.clinicaltrials.gov . Unique identifier: NCT02422888.
Analysis Of IgE Antigenic Determinants On Der p 2 For Design Of Immunotherapy
Authors: Jill Glesner, A. Brenda Kapingidza, Magdalena Godzwon, Lesa R. Offerman, Geoffrey A. Mueller, Eugene F. DeRose, Crystal M. Richardson, Mats Ohlin, Martin D. Chapman, Maksymilian Chruszcz, Anna Pomes
Journal: Journal of Allergy and Clinical Immunology (2019)
Treatment Outcomes of Real Life Elderly Multiple Myeloma Patients:Â Analysis from Registry of Monoclonal Gammopathies (RMG)
Authors: Jakub Radocha, Roman Hajek, Lucie Brozova, Ludek Pour, Ivan Spicka, Jiri Minarik, Evzen Gregora, Alexandra Jungova, Jan Straub, Tomas Jelinek, Tomas Pika, Petr Pavlicek, Viera Sandecka, David Vrabel, Adriana Heindorfer, Martin Stork, Michal Sykora, Vladimir Maisnar
Journal: Blood (2018)
Vaginal rings with exposed cores for sustained delivery of the HIV CCR5 inhibitor 5P12-RANTES
Authors: John W. McBride, Peter Boyd, Nicola Dias, David Cameron, Robin E. Offord, Oliver Hartley, Vicky L. Kett, R. Karl Malcolm
Journal: Journal of Controlled Release (2019)

Antiretroviral-releasing vaginal rings are at the forefront of ongoing efforts to develop microbicide-based strategies for prevention of heterosexual transmission of the human immunodeficiency virus (HIV). However, traditional ring designs are generally only useful for vaginal administration of relatively potent, lipophilic, and small molecular weight drug molecules that have sufficient permeability in the non-biodegradable silicone elastomer or thermoplastic polymers. Here, we report a novel, easy-to-manufacture 'exposed-core' vaginal ring that provides sustained release of the protein microbicide candidate 5P12-RANTES, an experimental chemokine analogue that potently blocks the HIV CCR5 coreceptor. In vitro release, mechanical, and stability testing demonstrated the utility and practicality of this novel ring design. In a sheep pharmacokinetic model, a ring containing two ¼-length excipient-modified silicone elastomer cores - each containing lyophilised 5P12-RANTES and exposed to the external environment by two large windows - provided sustained concentrations of 5P12-RANTES in vaginal fluid and vaginal tissue between 10 and 10,000 ng/g over 28days, at least 50 and up to 50,000 times the reported in vitro IC50 value.
Abstract 14567: Comparison of Weekday vs. Weekend Admission on Inpatient Mortality and Total Hospital Charge on Atrial Flutter and Fibrillation: A Nationwide Analysis
Authors: Shawn Lee, Alejandro Lemor, Farid Gholitabar, Carlos A Gongora, Abel Casso Dominguez, Paul T Kroner, Carolina Hurtado, Daniel Castaneda, Davendra Mehta
Journal: Circulation (2016)

Background: Weekend admissions have shown to be a predictor of inpatient mortality. We evaluated the impact of weekday vs. weekend admission in patients with Atrial Flutter and/or Fibrillation (AF)...
Efficacy and Safety of Bendamustine and Rituximab As First Salvage Treatment in Chronic Lymphocytic Leukemia: Results of the Gimema-Eric LLC1315 Study
Authors: Antonio Cuneo, Gian Matteo Rigolin, Alfonso Piciocchi, Carol Moreno, Atto Billio, Agostino Cortelezzi, Piero Galieni, Luca Laurenti, Francesca Romana Mauro, Stefano Molica, Massimo Gentile, Marco Montillo, Livio Trentin, Angeles Medina Perez, Marta Coscia, Gerardo Musuraca, Lucia Farina, Alfredo Rivas-Delgado, Ester Maria Orlandi, Stefania Ciolli, Carlo Visco, Michele Pizzuti, Roberto Marasca, Monia Marchetti, Francesca Re, Marcos González, Annalisa Chiarenza, Vittorio Meneghini, Fiorella Ilariucci, Gianluca Gaidano, Marco Vignetti, Javier De la Serna, Robin Foa, George A Follows, Paolo Ghia
Journal: Blood (2017)
Horner’s syndrome secondary to carotid artery dissection caused by Eagle syndrome
Authors: Christopher Wooton, Calum Adams, Mark Hunter, Julie McManus
Journal: BMJ (2019)

A 55 year old man presented with a 2 week history of headache, right sided ptosis, ipsilateral facial sensitivity, and anisocoria.

He underwent computed tomography angiography (fig 1).



Fig 1 
(Image courtesy of MA …
Abstract 20361: Evaluation of AAV9 Delivery and Gene Expression in a Mouse Model of PAD Using the Sodium Iodide Symporter and SPECT/CT
Authors: Nabil E Boutagy, Silvia Ravera, Xenophon Papademetris, Zhenwu Zhuang, Mitchel R Stacy, Xiangning Wang, Christi Hawley, Nancy Carrasco, Brent A French, Brian H Annex, Albert J Sinusas
Journal: Circulation (2017)

Introduction: Peripheral arterial disease (PAD) is complicated by claudication and amputation. Efforts to stimulate angiogenesis and improve flow with gene therapy have been met with limited succes...
Pathological Hepatic Contrast-Enhanced Ultrasound (CEUS) Pattern in Patients Undergoing Allogeneic Stem Cell Transplantation (allo-SCT)
Authors: Corinna Trenker, Andreas Burchert, Christian Sebastian Michel, Caren Schuhmacher, Jonas A. Schäfer, Marius Dohse, Andreas Neubauer, Kristina Sohlbach, Christian Görg
Journal: Blood (2018)
Editorial: 5G-Based mHealth Bringing Healthcare Convergence to Reality
Journal: IEEE Reviews in Biomedical Engineering (2019)

Discusses the benefits of mobile health(mHealth) technologies. These technologies empower patients to be more involved in their own care, give healthcare consumers greater access to providers, and vice versa, and allow for better personalized, precise, pervasive, and preventive medicine, in more effective and less costlyways.At the cutting edge of health engineering, the field of emerging mHealth promises a new era of highly individualized treatment of disease and preventive medicine, bringing the health convergence to reality.
Graph genomes article collection
Authors: Michael C. Schatz, Andrew Cosgrove
Journal: Genome biology (2019)

Extensive studies have been carried out on various hybrid energy systems (HESs) for providing electricity to off-grid areas.However, a standalone HES that is capable of providing power and gas, has been less studied.In this paper, a standalone Photovoltaic (PV)-battery-methanation HES is proposed to provide adequate, reliable and cost-effective electricity and gas to the local consumers.Identifying a potential solution to maximize the reliability of the system, asked by consumers, and to minimize costs required by the investors is challenging.Bi-level programming is adopted in this study to tackle the prementioned issue.In the outer layer, an optimal design is obtained by means of particle swarm optimization.In the inner layer, an optimal operation strategy is found under the optimal design of the outer layer using sequential quadratic programming.The results indicate that 1) The bi-level programming used in this study can find the optimal solution; 2) The proposed HES is proved to be able to supply power and gas simultaneously.3) Compared with the right most and leftmost points on Pareto set, the total costs are reduced by 17.77% and 2.16%.
Abstract 19741: Current Perspectives and Practices on Radiation Safety in the Catheterization Laboratory
Authors: Rohan Menon, Siddharth Patel, Aris Karatasakis, Barbara A Danek, Judit Karacsonyi, Bavana V Rangan, Tayo Addo, Dharam Kumbhani, Samir Kapadia, Michael Luna, Ehtisham Mahmud, Charles Chambers, Subhash Banerjee, Emmanouil S Brilakis
Journal: Circulation (2016)

Introduction: There is growing interest in improving radiation safety in the cardiac catheterization laboratory for both patients and operators. Methods: We developed and administered an online sur...
Abstract 15319: Association Between Renal Dysfunction and Outcomes in Out-of-Hospital Cardiac Arrest Patients: A Prospective, Multicenter Observational Study (SOS-KANTO 2012 Study)
Authors: Tomoyoshi Tamura, Masaru Suzuki, Kei Hayashida, Junichi Sasaki, Naohiro Yonemoto, Arino Yaguchi, Naoto Morimura, Atsushi Sakurai
Journal: Circulation (2017)

Introduction: Chronic kidney disease substantially increases the risk of cardiovascular death, but the effect of renal dysfunction on outcomes after cardiac arrest (CA) is unclear. Objective: The a...
Multifactorial heterogeneity of virus-specific T cells and association with the progression of human chronic hepatitis B infection
Authors: Yang Cheng, Yuan O. Zhu, Etienne Becht, Pauline Aw, Jinmiao Chen, Michael Poidinger, Paola Flórez de Sessions, Martin Lloyd Hibberd, Antonio Bertoletti, Seng Gee Lim, Evan W. Newell
Journal: Science Immunology (2019)

Associations between chronic antigen stimulation, T cell dysfunction, and the expression of various inhibitory receptors are well characterized in several mouse and human systems. During chronic hepatitis B virus (HBV) infection (CHB), T cell responses are blunted with low frequencies of virus-specific T cells observed, making these parameters difficult to study. Here, using mass cytometry and a highly multiplexed combinatorial peptide-major histocompatibility complex (pMHC) tetramer strategy that allows for the detection of rare antigen-specific T cells, we simultaneously probed 484 unique HLA-A*1101-restricted epitopes spanning the entire HBV genome on T cells from patients at various stages of CHB. Numerous HBV-specific T cell populations were detected, validated, and profiled. T cells specific for two epitopes (HBVpol387 and HBVcore169) displayed differing and complex heterogeneities that were associated with the disease progression, and the expression of inhibitory receptors on these cells was not linearly related with their extent of T cell dysfunction. For HBVcore169-specific CD8+ T cells, we found cellular markers associated with long-term memory, polyfunctionality, and the presence of several previously unidentified public TCR clones that correlated with viral control. Using high-dimensional trajectory analysis of these cellular phenotypes, a pseudo-time metric was constructed that fit with the status of viral infection in corresponding patients. This was validated in a longitudinal cohort of patients undergoing antiviral therapy. Our study uncovers complex relationships of inhibitory receptors between the profiles of antigen-specific T cells and the status of CHB with implications for new strategies of therapeutic intervention.
Inhibition of FOXO3a/BIM signaling pathway contributes to the protective effect of salvianolic acid A against cerebral ischemia/reperfusion injury
Authors: Junke Song, Wen Zhang, Jinhua Wang, Haiguang Yang, Qimeng Zhou, Haigang Wang, Li Li, Guanhua Du
Journal: Acta Pharmaceutica Sinica B (2019)

Salvianolic acid A (SalA) is an effective compound extracted from traditional Chinese medicine Salvia miltiorrhiza Bunge. The Forkhead box O3a (FOXO3a) signaling pathway plays crucial roles in the modulation of ischemia-induced cell apoptosis. However, no information about the regulatory effect of SalA on FoxO3a is available. To explore the anti-cerebral ischemia effect and clarify the therapeutic mechanism of SalA, SH-SY5Y cells and Sprague-Dawley rats were applied, which were exposed to oxygen glucose deprivation/reoxygenation (OGD/R) and middle cerebral artery occlusion/reperfusion (MCAO/R) injuries, respectively. The involved pathway was identified using the specific inhibitor LY294002. Results showed that SalA concentration-dependently inhibited OGD/R injury triggered cell viability loss. SalA reduced cerebral infarction, lowered brain edema, improved neurological function, and inhibited neuron apoptosis in MCAO/R rats, which were attenuated by the treatment of phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) specific inhibitor LY294002. SalA time- and concentration-dependently upregulated the phosphorylation levels of protein kinase B (AKT) and its downstream protein FOXO3a. Moreover, the nuclear translocation of FOXO3a was inhibited by SalA both in vivo and in vitro, which was also reversed by LY294002. The above results indicated that SalA fought against ischemia/reperfusion damage at least partially via the AKT/FOXO3a/BIM pathway.
Padi4 Regulates NET Formation and Inflammatory Cell Death Downstream of Mlkl
Authors: Akshay A D'Cruz, Mary Speir, Meghan Bliss-Moreau, Sylvia Dietrich, Alyce A Chen, Mathilde Gavillet, Kate E Lawlor, James E Vince, Michelle Kelliher, Razq Hakem, Manolis Pasparakis, David A Williams, Maria Ericsson, Ben A Croker
Journal: Blood (2018)
Response to: ‘Potential roles for tenascin in (very) early diagnosis and treatment of rheumatoid arthritis’ by Cutolo <i>et al</i>
Authors: Susan Aungier, Alison J Cartwright, Anja Schwenzer, Jennifer Marshall, Mike R Dyson, Peter Slavny, Kothai Parthiban, Aneesh Karatt-Vellatt, Ilfita Sahbudin, Eric Culbert, Patrick Hextall, Felix IL Clanchy, Richard Williams, Brian D Marsden, Karim Raza, Andrew Filer, Christopher D Buckley, John McCafferty, Kim S Midwood
Journal: Annals of the Rheumatic Diseases (2019)

Response to: 'Potential roles for tenascin in (very) early diagnosis and treatment of rheumatoid arthritis'
Depth of Anesthesia and Postoperative Delirium
Authors: Thomas E. F. Abbott, Rupert M. Pearse
Journal: JAMA (2019)

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Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study
Authors: Ashley Budu-Aggrey, Ben Brumpton, Jess Tyrrell, Sarah Watkins, Ellen H. Modalsli, Carlos Celis-Morales, Lyn D. Ferguson, Gunnhild Åberge Vie, Tom Palmer, Lars G. Fritsche, Mari Løset, Jonas Bille Nielsen, Wei Zhou, Lam C. Tsoi, Andrew R. Wood, Samuel E. Jones, Robin Beaumont, Marit Saunes, Pål Richard Romundstad, Stefan Siebert, Iain B. McInnes, James T. Elder, George Davey Smith, Timothy M. Frayling, Bjørn Olav Åsvold, Sara J. Brown, Naveed Sattar, Lavinia Paternoster
Journal: PLoS Medicine (2019)

Psoriasis is a common inflammatory skin disease that has been reported to be associated with obesity. We aimed to investigate a possible causal relationship between body mass index (BMI) and psoriasis.
Association of genetically predicted testosterone with thromboembolism, heart failure, and myocardial infarction: mendelian randomisation study in UK Biobank
Authors: Shan Luo, Shiu Lun Au Yeung, Jie V Zhao, Stephen Burgess, C Mary Schooling
Journal: BMJ (2019)

Abstract Objective To determine whether endogenous testosterone has a causal role in thromboembolism, heart failure, and myocardial infarction. Design Two sample mendelian randomisation study using genetic variants as instrumental variables, randomly allocated at conception, to infer causality as additional randomised evidence. Setting Reduction by Dutasteride of Prostate Cancer Events (REDUCE) randomised controlled trial, UK Biobank, and CARDIoGRAMplusC4D 1000 Genomes based genome wide association study. Participants 3225 men of European ancestry aged 50-75 in REDUCE; 392 038 white British men and women aged 40-69 from the UK Biobank; and 171 875 participants of about 77% European descent, from CARDIoGRAMplusC4D 1000 Genomes based study for validation. Main outcome measures Thromboembolism, heart failure, and myocardial infarction based on self reports, hospital episodes, and death. Results Of the UK Biobank participants, 13 691 had thromboembolism (6208 men, 7483 women), 1688 had heart failure (1186, 502), and 12 882 had myocardial infarction (10 136, 2746). In men, endogenous testosterone genetically predicted by variants in the JMJD1C gene region was positively associated with thromboembolism (odds ratio per unit increase in log transformed testosterone (nmol/L) 2.09, 95% confidence interval 1.27 to 3.46) and heart failure (7.81, 2.56 to 23.8), but not myocardial infarction (1.17, 0.78 to 1.75). Associations were less obvious in women. In the validation study, genetically predicted testosterone (based on JMJD1C gene region variants) was positively associated with myocardial infarction (1.37, 1.03 to 1.82). No excess heterogeneity was observed among genetic variants in their associations with the outcomes. However, testosterone genetically predicted by potentially pleiotropic variants in the SHBG gene region had no association with the outcomes. Conclusions Endogenous testosterone was positively associated with thromboembolism, heart failure, and myocardial infarction in men. Rates of these conditions are higher in men than women. Endogenous testosterone can be controlled with existing treatments and could be a modifiable risk factor for thromboembolism and heart failure.
Long-Term AL Amyloidosis Survivors Among Non-Selected Referral Population
Authors: Eli Muchtar, Morie A. Gertz, Martha Q. Lacy, David Dingli, Francis K. Buadi, Martha Grogan, Omar F. abou Ezzeddine, Suzanne R. Hayman, Prashant Kapoor, Nelson Leung, Amie Fonder, Miriam Hobbs, Yi Hwa, Wilson I Gonsalves, Rahma Warsame, Taxiarchis Kourelis, Stephen J. Russell, John A. Lust, Yi Lin, Ronald S. Go, Steven Zeldenrust, Robert A. Kyle, S. Vincent Rajkumar, Shaji K. Kumar, Angela Dispenzieri
Journal: Blood (2018)
Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells
Authors: Hongwei Du, Koichi Hirabayashi, Sarah Ahn, Nancy Porterfield Kren, Stephanie Ann Montgomery, Xinhui Wang, Karthik Tiruthani, Bhalchandra Mirlekar, Daniel Michaud, Kevin Greene, Silvia Gabriela Herrera, Yang Xu, Chuang Sun, Yuhui Chen, Xingcong Ma, Cristina Rosa Ferrone, Yuliya Pylayeva-Gupta, Jen Jen Yeh, Rihe Liu, Barbara Savoldo, Soldano Ferrone, Gianpietro Dotti
Journal: Cancer Cell (2019)
Abstract 20833: Extension and Recurrence of Spontaneous Coronary Artery Dissection
Authors: Tony Main, Andrew Starovoytov, Roshan Prakash, G.B. J Mancini, Eve Aymong, Jacqueline Saw
Journal: Circulation (2017)

Aims: Spontaneous coronary artery dissection (SCAD) is an under-recognized and important cause of myocardial infarction in young women. Recurrent SCAD is frequent but poorly understood. We aim to explore the clinical and angiographic characteristics, and outcomes of recurrent SCAD. Methods and Results: Patients with SCAD extension or recurrence prospectively followed at Vancouver General Hospital were included. SCAD diagnosis was confirmed by 2 experienced cardiologists. Detailed medical history, baseline demographics, angiographic results, and clinical details of index SCAD and recurrent events were recorded. SCAD extension was defined as angiographic extension of previously dissected coronary segment, and recurrent SCAD was defined as de novo spontaneous dissection. We identified 43 patients with SCAD extension or recurrence with mean age 48.9±8.4 years, 38/43 were women, and 32/43 had fibromuscular dysplasia. Nine patients had SCAD extension at median time of 5 (1-19) days, while 34 patients had recurr...
Abstract 19116: Prognostic Performance of GDF-15 Across the Spectrum of Risk in Patients With NSTE-ACS Enrolled in MERLIN - TIMI 36
Authors: Michael G Silverman, Thomas Zelniker, Erin A Bohula, Jeong-Gun Park, Marc P Bonaca, Benjamin M Scirica, David A Morrow
Journal: Circulation (2017)

Introduction: Growth differentiation factor (GDF)-15 has been associated with cardiovascular (CV) outcomes in ACS using research use only assays. We evaluated the prognostic performance of GDF-15 m...