AB1277 Vaccination status and knowledge and attitude on vaccine among patients with rheumatic disease in china
Authors: Y. Jiang, X. Li, X. Zhang, Q. Lv, Y. Zhang, J. Qi, Z. Liao, J. Gu
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Rheumatic diseases are associated with an increased susceptibility to infections.<sup>1</sup> Specific inactivated vaccinations are recommended for patients with autoimmune diseases.<sup>2–4</sup> However, vaccination coverage among patients with rheumatic disease is extremely low in China. <h3>Objectives</h3> Our study was to discover infection and vaccination status in patients with rheumatic diseases in recent five years. and then to determine knowledge and attitude on vaccine among patients with rheumatic diseases. <h3>Methods</h3> A questionnaire-based survey was conducted in a total of 242 patients. The Statistical Package for Social Sciences (SPSS) software version 21 was used for all data management and analysis. <h3>Results</h3> Of 242 patients, mean age was 39.84±4.42. Mean disease duration was 30.00%±4.42. 55% had connective tissue disease. 7 patients had herpes zoster infection. 4 had influenza. 5 had pneumonia, 1 had dengue fever. And 1 had herpes genitalis infection in recent 5 years. Only 15 patients (6.2%) had vaccination in recent 5 years. 2 female patients had inoculation of human papillomavirus (HPV) vaccine. 3 patients took shots of hepatitis B virus (HBV). 2 were vaccinated for tetanus, 4 for rabies vaccine and 1 for influenza. 159 (65.7%) of the patients had heard of influenza vaccine. Only 62 (25.6%) had heard of pneumococcal vaccine. 103 (43.6%) of the participants knew where to take vaccine. Only 9 patients had reported of former doctors' advice to taking vaccine (influenza, 2). 144 (59.5%) believed influenza could turn to serious infection. 47.5% had correct knowledge of vaccination function. Only 42.1% believed vaccine was safe and valid. 8.3% of the patients thought vaccination was useless. 57.4% of the patients would like to take vaccine if medical insurance could cover vaccination. Only 37.6% of the patients preferred to take vaccine with doctors' recommendation. <h3>Conclusions</h3> There is a need for educational intervention and awareness campaigns over the importance of vaccination in patients with rheumatic diseases. <h3>References</h3> [1] 1. van Assen S, Elkayam O, Agmon-Levin N, et al. Vaccination in adult patients with auto-immune inflammatory rheumatic diseases: a systematic literature review for the European League Against rheumatism evidence-based recommendations for vaccination in adult patients with auto-immune inflammatory rheumatic diseases. Autoimmun Rev 2011;10(6): 341e52. [2] Papadopoulou D, Sipsas NV. Comparison of national clinical practice guidelines and recommendations on vaccination of adult patients with autoimmune rheumatic diseases. Rheumatol Int 2014;34(2):151e63. [3] van Assen S, Agmon-Levin N, Elkayam O, et al. EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases. Ann Rheum Dis 2011;70(3):414e22. [4] Singh JA, Furst DE, Bharat A, et al. 2012update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis. Arthritis Care Res (Hoboken) 2012;64(5):625e39. <h3>Acknowledgements</h3> None. <h3>Disclosure of Interest</h3> Y. Jiang: None declared, X. Li: None declared, X. Zhang: None declared, Q. Lv: None declared, Y. Zhang: None declared, J. Qi: None declared, Z. Liao Grant/research support from: National Natural Sciences Foundation of China [grant number 81201372], J. Gu Grant/research support from: the 5010 Subject of Sun Yat-sen University (2007023)