tbuckley/cabot-search huggingface dataset:
SETD2 regulates the maternal epigenome, genomic imprinting and embryonic development
Authors: Qianhua Xu, Yunlong Xiang, Qiujun Wang, Leyun Wang, Julie Brind’Amour, Aaron Blair Bogutz, Yu Zhang, Bingjie Zhang, Guang Yu, Weikun Xia, Zhenhai Du, Chunyi Huang, Jing Ma, Hui Zheng, Yuanyuan Li, Chao Liu, Cheryl Lyn Walker, Eric Jonasch, Louis Lefebvre, Min Wu, Matthew C. Lorincz, Wei Li, Li Li, Wei Xie
Journal: Nature Genetics (2019)
Quorum sensing between bacterial species on the skin protects against epidermal injury in atopic dermatitis
Authors: Michael R. Williams, Stephen K. Costa, Livia S. Zaramela, Shadi Khalil, Daniel A. Todd, Heather L. Winter, James A. Sanford, Alan M. O’Neill, Marc C. Liggins, Teruaki Nakatsuji, Nadja B. Cech, Ambrose L. Cheung, Karsten Zengler, Alexander R. Horswill, Richard L. Gallo
Journal: Science Translational Medicine (2019)

Quorum sensing peptides produced by commensal skin staphylococci protect against skin injury and inflammation induced by Staphylococcus aureus toxins.
Medics do nursing
Authors: Harnaik Bajwa
Journal: BMJ (2006)

Medical students should have to complete a week of hospital nursing before being allowed to qualify as doctors. Too often, medical students and recently qualified doctors do not fully understand the work of nurses, and this can affect standards of work. Whether they are the nurse in charge or the auxiliary nurse, nurses are highly important and yet many doctors fail to make regular use of their knowledge and unique understanding of patients. The relationship between doctor and nurse can be a difficult one and can sometimes be volatile and unproductive.

Introducing …
Book review: Surgical Ethics
Authors: Michael Baum
Journal: BMJ (2000)

I started reading this book in a week that the medical profession was being pilloried because of several high profile cases of doctors passing through the disciplinary process of the General Medical Council. That week was also associated with the publication of a report by a distinguished barrister, claiming that consultant surgeons were being treated like gods.

I wrote to the Times explaining that after 30 years as a consultant surgeon I could confirm that surgeons were indeed treated like gods. We are expected to perform miracles with inadequate resources and to mate. rialise in several places at the same time because of inadequate staffing levels. Perhaps I …
Angelhead. My brother's descent into madness
Authors: Sally-Ann S Price
Journal: BMJ (2001)

“My brother saw the face of God. You never recover from a trauma like that.” This is the beginning of Michael Bottoms's descent into madness. The journey was a long and painful one characterised by desperation and ultimately despair. Consequently, this—his brother's account of the journey—is a dark and arduous book.

Michael developed schizophrenia after taking LSD. Perhaps the LSD contributed; perhaps it precipitated that first psychotic episode; perhaps it played no part at all. Bottoms remembers that Michael had always been odd, mean, and violent. There was …
Abstract 17608: Ethnic and Sex Differences in Ambulance Activation Among Hospitalized Patients With St-elevation Myocardial Infarction
Authors: Arjun Gupta, Padma Kaul, Wendimagegn Alemayehu, Robert Welsh, Kevin Bainey
Journal: Circulation (2016)

Introduction: Emergency medical service (EMS) activation has become an integral component in managing ST-elevation myocardial infarction (STEMI) patients. Within an integrated STEMI system of care,...
Benefits and challenges with diagnosing chronic and late acute GVHD in children using the NIH consensus criteria
Authors: Geoffrey D. E. Cuvelier, Eneida R. Nemecek, Justin T. Wahlstrom, Carrie L. Kitko, Victor A. Lewis, Tal Schechter, David A. Jacobsohn, Andrew C. Harris, Michael A. Pulsipher, Henrique Bittencourt, Sung Won Choi, Emi H. Caywood, Kimberly A. Kasow, Monica Bhatia, Benjamin R. Oshrine, Allyson Flower, Sonali Chaudhury, Donald Coulter, Joseph H. Chewning, Michael Joyce, Süreyya Savaşan, Anna B. Pawlowska, Gail C. Megason, David Mitchell, Alexandra C. Cheerva, Anita Lawitschka, Lori J. West, Bo Pan, Yazid N. Al Hamarneh, Anat Halevy, Kirk R. Schultz
Journal: Blood (2019)

Abstract Chronic graft-versus-host disease (cGVHD) and late acute graft-versus-host disease (L-aGVHD) are understudied complications of allogeneic hematopoietic stem cell transplantation in children. The National Institutes of Health Consensus Criteria (NIH-CC) were designed to improve the diagnostic accuracy of cGVHD and to better classify graft-versus-host disease (GVHD) syndromes but have not been validated in patients &amp;lt;18 years of age. The objectives of this prospective multi-institution study were to determine: (1) whether the NIH-CC could be used to diagnose pediatric cGVHD and whether the criteria operationalize well in a multi-institution study; (2) the frequency of cGVHD and L-aGVHD in children using the NIH-CC; and (3) the clinical features and risk factors for cGVHD and L-aGVHD using the NIH-CC. Twenty-seven transplant centers enrolled 302 patients &amp;lt;18 years of age before conditioning and prospectively followed them for 1 year posttransplant for development of cGVHD. Centers justified their cGVHD diagnosis according to the NIH-CC using central review and a study adjudication committee. A total of 28.2% of reported cGVHD cases was reclassified, usually as L-aGVHD, following study committee review. Similar incidence of cGVHD and L-aGVHD was found (21% and 24.7%, respectively). The most common organs involved with diagnostic or distinctive manifestations of cGVHD in children include the mouth, skin, eyes, and lungs. Importantly, the 2014 NIH-CC for bronchiolitis obliterans syndrome perform poorly in children. Past acute GVHD and peripheral blood grafts are major risk factors for cGVHD and L-aGVHD, with recipients ≥12 years of age being at risk for cGVHD. Applying the NIH-CC in pediatrics is feasible and reliable; however, further refinement of the criteria specifically for children is needed.
Selective dorsal rhizotomy in ambulant children with cerebral palsy: an observational cohort study
Authors: Jennifer Summers, Bola Coker, Saskia Eddy, Maria Elstad, Catey Bunce, Elli Bourmpaki, Mark Pennington, Kristian Aquilina, Stephanie Cawker, Richard Edwards, John Goodden, Sally Hawes, Kate McCune, Benedetta Pettorini, Jennifer Smith, Christine Sneade, Michael Vloeberghs, Hannah Patrick, Helen Powell, Christopher Verity, Janet L Peacock
Journal: The Lancet Child & Adolescent Health (2019)

BackgroundSelective dorsal rhizotomy (SDR) is an irreversible surgical procedure involving the division of selected sensory nerve roots, followed by intensive physiotherapy. The aim is to improve function and quality of life in children with cerebral palsy and a Gross Motor Function Classification System (GMFCS) level of II or III (walks with or without assistive devices, respectively). We assessed gross motor function before and after SDR and postoperative quality of life in a study commissioned by NHS England.MethodsWe did a prospective observational study in five hospitals in England who were commissioned to perform SDR on children aged 3–9 years with spastic diplegic cerebral palsy. The primary outcome was score changes in the 66-item Gross Motor Function Measure (GMFM-66) and seven domains of the Cerebral Palsy Quality of Life Questionnaire ([CP-QoL] social wellbeing and acceptance, feelings about functioning, participation and physical health, emotional wellbeing and self-esteem, access to services, family health, and pain and impact of disability) from before to 24 months after SDR.FindingsFrom Sept 4, 2014, to March 21, 2016, 137 children underwent SDR. The mean age was 6·0 years (SD 1·8). The mean GMFM-66 score increased after SDR with an annual change of 3·2 units (95% CI 2·9 to 3·5, n=137). Of the seven CP-QoL domains, five showed significant improvements over time: feelings about functioning mean annual change 3·0 units (95% CI 2·0 to 4·0, n=133), participation and physical health 3·9 units (2·5 to 5·3, n=133), emotional wellbeing and self-esteem 1·3 units (0·2 to 2·3, n=133), family health 2·0 units (0·7 to 3·3, n=132), and pain and impact of disability −2·5 units (−3·9 to −1·2, n=133). 17 adverse events were reported in 15 children, of which none were severe and 15 (88%) resolved.InterpretationSDR improved function and quality of life in the 24 months after surgery in children with cerebral palsy classified as GMFCS levels II and III. On the basis of these findings, an interim national policy decision was made that SDR would be funded for eligible children in England from 2018.FundingNational Institute for Health and Care Excellence, National Institute for Health Research Biomedical Research Centre, NHS England.
A creative intercalated experience
Authors: Alex J Hamilton
Journal: BMJ (2006)

Medicine is my lawful wedded wife, and literature my mistress. When one gets on my nerves, I spend the night with the other…neither loses anything by this duplicity. Anton Chekhov, when questioned about being a writer and a doctor

Intercalated bachelors degree? Fine. Picking a course? Well, no problem. Project? My stomach churned. I despaired, shuddering with nausea at the prospect of a lab project, pinching away the numbness of a library project, and quashing the hopeful glimmer of a clinical project.

PubMed searches filled me with fear. Papers were not my cup of tea. And …
We should help fight tuberculosis
Authors: Benjamin Geisler
Journal: BMJ (2003)

Medical students need to help in the fight against tuberculosis. The Stop TB movement is organised in partnerships, globally and nationally, which enables all stakeholders to be engaged and makes the most of previously untapped resources. Until now, medical students from only a few countries have been active in Stop TB; future doctors should now be involved in national tuberculosis partnerships.

Mycobacterium tuberculosis infects 100 million people each year, 8.7 million develop tuberculosis, and 1.7 million die. One third of the world's population is infected and tuberculosis has killed more humans than any other disease-about a billion people.12 After a steady decline, prevalence increased again in the late 1980s and in the past decade.3

Engaging medical students in national tuberculosis partnerships would evaluate, sustain, and if necessary improve the quality of medical education about tuberculosis. Medical students can …
Film review: On earth as it is in hell
Authors: Lawrence Brown
Journal: BMJ (2000)

Two recent films, Broken Vessels and Bringing Out the Dead , portray the lives of those who work for the emergency medical services in urban America. Or at least they claim to.

Broken Vessels tells the story of Tom (Jason London), an emergency medical technician who arrives in Los Angeles while trying to escape his past in Altoona, Pennsylvania. He lands a job as an ambulance driver and is teamed up with Jimmy (Todd Field), a senior Los Angeles paramedic whose best skill seems to be snatching his sunglasses off his face and trying to look cool.



More about drug addiction than paramedics



Ten minutes into the movie the two are drinking alcohol, picking up women, having sex, buying heroin on the street corner, and getting high. All of this happens while they are on duty, mostly in the ambulance. Then they start stealing from their patients to support their drug habits. …
A painful foot in a young boy
Authors: Baskaran Komarasamy, Ramanan Vadivelu
Journal: BMJ (2005)

A 12-year-old white boy presented to the emergency department with a history of recurrent painful left foot. In the past, he had noticed vague dull ache in his left hindfoot, which occasionally became painful on severe exertion. Analgesics and rest for a few days eased his pain during these acute episodes. A detailed history and physical examination of his left foot found mild swelling and tenderness over the dorsum of the foot and in the mid-tarsal region. He had the full range of movements in all the joints of his forefoot and mid-foot. Movement in his hindfoot was slightly restricted (figure).



Fig 1 
Plain radiograph of oblique view of the boy's left foot



1.  What are the features seen on the plain radiograph?

2.  What are the differential diagnoses for his hindfoot pain?

3.  What is the diagnosis?

4.  What is tarsal coalition? And what are the types of tarsal coalition?

5.  What is the line …
Finding the Magic in Magic Mouthwash
Authors: Yubin Cao, Chunjie Li, Longjiang Li
Journal: JAMA Internal Medicine (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Personal View: One way to reduce the overdraft
Authors: Jennifer Nichols
Journal: BMJ (2000)

Student debt is at the forefront of most students' minds. Every student knows the joy of trying to persuade the bank manager to increase his or her overdraft limit. My housemates and I are no exception.

A few weeks ago I found myself talking to my bank manager. He tried to be sympathetic, but I'm trying to increase my limit for the umpteenth time. Finally, we got round to the inevitable question, “How exactly do you plan to bring your overdraft back down to a manageable limit?” I stuttered a bit, and made a few excuses, but after putting the phone down I thought, “How am I going to pay this back?” I tend to view the overdraft as free money, but living at the limit of your overdraft is beginning to get dull. So how could I make money quickly, and with relatively little effort on my part?



Insertion of a flexible bronchoscope (ANTONIA REEVE/ SPL)



This is when we started to discuss taking part in research experiments. One …
Abstract 143: The Inner Mitochondrial Membrane Protein Mpv17 is Crucial for Myocardial Recovery From Ischemia Reperfusion Injury
Authors: Ngonidzashe B Madungwe, Yansheng Feng, Mihaela Lie, Jean C Bopassa
Journal: Circulation Research (2017)

Introduction: The MPV17 mutation in humans is an autosomal recessive disorder that results in mitochondrial DNA depletion syndromes (MDS) leading to hepatocerebral defects. Previously attributed to unknown functions, the MPV17 protein has recently been shown in the liver and kidney to be a non-selective channel in the inner membrane of mitochondria whose function is tied to membrane potential (ΔΨ m ), pH and reactive oxygen species (ROS) generation. These mitochondrial functions are critical in ischemia/reperfusion (I/R) injury caused by myocardial infarction, but despite this, however, Mpv17’s role in the myocardium is still unknown. We hypothesized that Mpv17 plays a critical role in cardiac responses to I/R injury. Methods: To investigate the role of cardiac Mpv17 protein in response to I/R injury, we measured cardiac functional recovery and myocardial infarct size in isolated hearts from in Mpv17 -/- and wildtype mice subjected to I/R. Additionally, we assessed mitochondrial ROS production, calcium retention capacity (CRC) required to induce mitochondrial permeability transition pore (mPTP) opening, ΔΨ m and cristae morphology in isolated mitochondria from the same mice. Results: We found that normal Mpv17 -/- mice exhibit similar cardiac and mitochondrial characteristics to wildtype, but after I/R, knockout mice show less cardiac functional recovery and increased myocardial infarct size. Mitochondria in these mice had more damaged cristae and reduced CRC, but surprisingly less ROS production compared to wildtype mice. Conclusion: These results shed more light onto the function of the Mpv17 protein and suggest it is critical in cardioprotection against I/R injury, and the cardiac mitochondrial response to I/R stress.
Organising and carrying out an elective project
Authors: Rusheng Chew
Journal: BMJ (2006)

There are many good reasons for doing a project on your elective, including personal interest, increased funding opportunities, and availability of a dedicated period of time. A well thought out and completed project also looks good on your CV. Here are some tips on getting that idea off the ground and seeing it through to the end.

Plan early — The process is often long, especially if hurdles like ethical approval need to be …
Methodology of Evaluating the Laboratory Monitoring of Terbinafine Therapy
Authors: Joerg Albrecht, Owen N. Kramer
Journal: JAMA Dermatology (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Book review: An Unquiet Mind
Authors: Sally-Ann S Price
Journal: BMJ (2000)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Book review: An Unquiet Mind Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
15 minute interview: Social responsibility
Authors: Thomas Mac Mahon
Journal: BMJ (2005)

The aim of the organisation is to assemble people in the healthcare profession to combat apathy, injustice, and inequality in Ireland, in Europe, in general, and internationally. It began last year when we attended the International Physicians for the Prevention of Nuclear War conference in Berlin and were impressed by what so many other countries' students were doing. When we were asked about Ireland, we had to say that we knew of nothing similar.

Traditionally, throughout Europe, mental health has been a major source of conflict over human rights and the rights of the individual. In Ireland, mental health legislation has not been reformed since the 1960s, so last December we put in our recommendations for its overhaul. We also held a series of workshops to educate medical students on refugee health, mental health, and the health of the homeless. At the end of each workshop we considered action points, so, for example, there is an enormous language barrier between refugees and time-limited general practitioners or hospital staff. With …
Chest pain after vomiting
Authors: Nazam Mohammed, Manoj Purohit, Andrew Duncan
Journal: BMJ (2006)

A 66 year old man, previously fit and well, was admitted to the emergency department with sudden pain in his left chest and abdomen after vomiting. He had woken in the early hours of the morning, vomited three times, and started getting progressively worsening pain in the left side of his chest and abdomen, radiating to the shoulder. He was a non-smoker and occasional drinker. He had no history of operations or similar episodes.

On arrival he was pale, sweaty, clammy, and had fever. His pulse was 106 beats/min and regular. His blood pressure was 92/52 mm Hg. Jugular venous pulse and heart sounds were normal.

Trachea was central, and respiratory rate was 40 breaths/min. Left lung base was dull on percussion, and air entry was diminished. His abdomen was soft, with generalised tenderness and normal bowel sounds.

Full blood count, liver function tests, serum electrolytes and serum amylase were normal. His troponin I concentration was below 0.03 (normal range 0-0.1) ng/ml and the concentration of C reactive protein was less than 1 (<10) mg/l. Blood gas analysis showed mild metabolic acidosis, and an electrocardiogram showed sinus tachycardia. Attending doctors took an urgent x ray scan of his chest (fig 1) and a computed tomograph of his chest and abdomen (fig 2).



Fig 1 
X ray image of the posteroanterior view of the chest, showing left hydropneumoth orax





Fig 2 
Computed tomography, showing mediastinal air and left hydropneumoth orax



Imagine you are managing this patient.

1.  What are the possible differential diagnoses, and what is the most likely cause?

2.  How would you interpret the radiograph of the chest (fig 1)?

3.  What should be the initial management, and how would you reach a definitive diagnosis?

4.  How would you interpret the computed tomograph of the chest (fig 2)?

1.  Differential diagnoses include …
Hybrid-biopsy endoscopic mucosal resection: an effective and simple technique for flat colorectal lesions
Authors: Miguel Fraile-López, Aida Jawhari, Samira Asgari, Stefano Sansone, Shiv Budihal, Adolfo Parra-Blanco
Journal: Endoscopy (2019)

Hybrid resection techniques (endoscopic mucosal resection [EMR] and endoscopic submucosal dissection [ESD]) [1] [2] [3] [4] [5] have been described to facilitate complete removal of flat lesions. They may be useful in challenging cases where the snare slips, such as in laterally spreading lesions of the nongranular type (LST-NG), fibrosis due to previous resection attempts, and submucosal fatty tissue, among other factors. However, endoscopists not experienced in ESD may not feel confident performing circumferential incision with a dedicated knife or the tip of a snare, and indeed would be unsafe if they were inexperienced in this technique.
Abstract 14308: Dabigratan Has a Higher Risk of Left Atrial Appendage Thrombus Formation in Patients With Af When Compared to Warfarin and Rivaroxaban
Authors: Luigi Di Biase, J. David Burkhardt, Gregg Gilbert, Pasquale Santangeli, Francesco Santoro, Javier Sanchez, Rodney Horton, Prasant Mohanty, Sanghamitra Mohanty, Rong Bai, Chintan Trivedi, Dhanunjay Lakkireddy, Madhu Reddy, Claude S Elayi, Richard Hongo, Viles Gonzalez Juan F, Salwa Beheiry, Steven Hao, Robert A Schweikert, Jason Zagrodzky, Andrea Natale
Journal: Circulation (2013)

Introduction: Transesophageal echocardiography (TEE) has been demonstrated to be a sensitive tool to detect left atrial thrombi in patients with AF before electrical cardioversion or before AF abla...