THU0448 NO DIFFERENCE IN GOUT FLARES AFTER INITIATION OF URATE LOWERING THERAPY BETWEEN ONCE OR TWICE DAILY 0.5 MG COLCHICINE PROPHYLAXIS
Authors: F. Veenstra, L. M. Verhoef, L. Nieboer, A. Den Broeder, W. Y. Kwok, I. Meek, F. Van den Hoogen, N. Van Herwaarden, M. Flendrie
Journal: Annals of the Rheumatic Diseases (2020)

Background: Initiation of urate lowering therapy (ULT) is associated with an increase in gout flares 1 . Therefore, guidelines advice prophylactic therapy during the first six months of ULT 2 . Colchicine 0.5-1 mg/day is recommended. Whether 1 mg/day colchicine is superior to 0.5 mg/day is unknown. Objectives: To examine the difference in gout flares in the first six months after initiation of ULT between 0.5 and 1.0 mg/day colchicine prophylaxis. Methods: Patients with clinical diagnosis of gout, a first outpatient visit between January 2010 and March 2018 and a follow-up of at least 6 months were included in a retrospective cohort study, conducted in two rheumatology centres in the Netherlands. Within this cohort, patients starting ULT and colchicine prophylaxis were selected. Difference in gout flare incidence density (ID) in the first six months after start of ULT between colchicine 0.5 and 1.0 mg/day was analysed using Poisson regression, corrected for confounders. Secondary analyses included the proportion of patients reaching a target of serum urate acid (SUA) of &lt; 0.36 mmol/l within the first six months. Results: Of 2108 gout patients, 379 patients started ULT and used colchicine prophylaxis (table 1). ID of flares was 2.8 and 2.6 per patient year on colchicine 1.0 and 0.5 mg/day respectively, resulting in an incidence rate ratio of 1.05 (95% CI 0.86 – 1.27). Within the first six months 68% in the colchicine 1mg/day and 63% in the colchicine 0.5 mg/day reached their target (difference 5%, 95% CI -0.08 – 0.18). Table 1. Baseline patient, disease and treatment characteristics Colchicine prophylaxis 0,5 mg/day (n=275 ) 1 mg/day (n=104 ) Men, no. (%) 226 (82%) 88 (85%) Age, years 67.3 (58.8-76.3) 65.3* (54.4-71.9) BMI, kg/m 2 29.0 (26.1-32.1) 29.5 (27.9-31.6) Comorbidity no. (%) Hypertension 146 (53%) 54 (52%) Diabetes Mellitus 66 (24%) 24 (23%) Hypercholesterolemia 43 (16%) 15 (14%) Renal insufficiency 56 (20%) 18 (17%) Crystal-confirmed diagnosis, no. (%) 197 (72%) 77 (74%) Serum urate acid at start ULT (mmol/l), mean ± SD 0.51 ± 0.11 0.50 ± 0.11 ULT medication, no. (%) Allopurinol 272 (99%) 103 (99%) Benzbromaron 2 (0.6%) Febuxostat 1 (0.4%) 1 (1%) *Compared to colchicine 0,5 mg/day, P&lt;0.05. **No SD possible, n = 1. Conclusion: Use of 1 mg/day colchicine is not superior to 0.5 mg/day as prophylaxis for ULT induced gout flares. For generalisability it should be noted that flare rates were not very high, probably due to the background ULT being characterised by a “start low, go slow” approach. In this context colchicine 0.5 mg/day is sufficient as prophylaxis. References: [1]Seth R et al. J Rheumatol 2014;92;42-47. [2]Richette P et al. Ann Rheum Dis 2017;76:29–42. Disclosure of Interests: : Frouwke Veenstra: None declared, L.M. Verhoef: None declared, Lieke Nieboer: None declared, Alfons den Broeder: None declared, Wing-Yee Kwok: None declared, Inger Meek: None declared, Frank van den Hoogen: None declared, Noortje van Herwaarden: None declared, Marcel Flendrie Grant/research support from: M. Flendrie has received grants from Menarini and Grunenthal. , Consultant of: M. Flendrie has received consultancy fees from Menarini and Grunenthal.