tbuckley/cabot-search huggingface dataset:
Maintenance Therapy in Newly Diagnosed and Transplant Ineligible Multiple Myeloma Patients: A Meta-Analysis
Authors: Abdul Rafae, Ali Jaan, Zahoor Ahmed, Karun Neupane, Sara Ashraf, Sundas Ali, Sana Irfan Khan, Israr Khan, Atif Irfan Khan, Ahsan Wahab, Rabia Ali, Sara Saeed, Mustafa Nadeem Malik, Faiz Anwer
Journal: Blood (2020)
Deconvolution of the Immune Microenvironment Can Predict the Outcome of Myeloma Patients and Inform Potential Intervention Strategies
Authors: Samuel Danziger, Andrew P Dervan, Frank Schmitz, Brian A Walker, Wilbert Copeland, Alison Fitch, Kathryn Newhall, Cody Cody Ashby, Michael Bauer, Bart Barlogie, Teri Foy, Matthew Trotter, Rob Hershberg, Alexander Ratushny, Gareth J. Morgan
Journal: Blood (2017)
Infant Acute Myeloid Leukemia with t(X;6)(p11;q23)/<i>MYB-GATA1</i>- a First Female Case in the Entity
Authors: Elena Zerkalenkova, Ludmila Zemtsova, Aleksandra Borkovskaya, Marina Gaskova, Marat Kazanov, Michael Maschan, Alexey Maschan, Galina Novichkova, Yulia Olshanskaya
Journal: Blood (2020)
Clinical Utility of Flow Cytometry Immunophenotyping in Acute Lymphoblastic Leukemia
Authors: Alessandra Suelen Jardim Silva, Gustavo Henrique de Medeiros Oliveira, Lenilton Silva DA Silva Júnior, Hugo Henrique de Freitas Ferreira, Maria das Graças Pereira Araujo, Victor lima Soares, Rodrigo Villar Freitas, Frank Bahia, Taissa Moura Oliveira, Dany GKC Silva, Valéria SF Sales, Rodolfo DA Soares, Hugo Diogenes De Oliveira Paiva, Aldair Sousa Paiva, Geraldo Barroso Cavalcanti
Journal: Blood (2020)
Clinical Outcomes and Influence of Mutation Clonal Dominance in Oligomonocytic and Classical Chronic Myelomonocytic Leukemia
Authors: Guillermo Montalban Bravo, Rashmi Kanagal-Shamanna, Veronia Guerra, Jorge M. Ramos Perez, Danielle Hammond, Shilpa Paul, Kiran Naqvi, Koji Sasaki, Elias Jabbour, Courtney D. DiNardo, Koichi Takahashi, Marina Konopleva, Naveen Pemmaraju, Tapan M. Kadia, Farhad Ravandi, Naval Daver, Gautam Borthakur, Zeev E. Estrov, Joseph D. Khoury, Sanam Loghavi, Sherry A. Pierce, Carlos E. Bueso-Ramos, Keyur Patel, Hagop M. Kantarjian, Guillermo Garcia-Manero
Journal: Blood (2020)
Outcomes of Patients with Limited-Stage Plasmablastic Lymphoma
Authors: Brian T. Hess, Anshu Giri, Yeonhee Park, Krina K. Patel, Brian K. Link, Grzegorz S. Nowakowski, Seth M Maliske, Sonia Fortin, Julio C. Chavez, Hayder Saeed, Brian T. Hill, Alex V. Mejia Garcia, Kami J. Maddocks, Walter Hanel, Nina D. Wagner-Johnston, Marcus Raymond Messmer, Brad S. Kahl, Marcus Watkins, Juan Pablo Alderuccio, Izidore S. Lossos, Sunita Nathan, Victor M. Orellana-Noia, Craig A. Portell, Daniel J. Landsburg, Emily C. Ayers, Jorge J. Castillo
Journal: Blood (2020)
Association of Epstein-Barr Virus with Advanced Stage and Survival Outcomes in Classic Hodgkin's Lymphoma
Authors: Samer Al Hadidi, Ranjit Nair, Raphael E Steiner, Sairah Ahmed, Paolo Strati, Simrit Parmar, Swami P. Iyer, Jillian R. Gunther, Chelsea C. Pinnix, Bouthaina S. Dabaja, Yago Nieto, Felipe Samaniego, Branko Cuglievan, Preetesh Jain, Penny Fang, Roberto N. Miranda, Jeffrey Medeiros, Lei Feng, Hubert Chuang, Michael Wang, Hun Ju Lee
Journal: Blood (2020)
End of Treatment Peripheral Blood T-Cell Receptor Gene Rearrangement Evaluation for Minimal Residual Disease Evaluation in Peripheral T-Cell Lymphomas
Authors: Neha Mehta-Shah, Todd A Fehniger, Eric D Jacobsen, Katrina Peterson, Brad S. Kahl, Nancy L. Bartlett, Amanda F Cashen, Armin Ghobadi, Anne Fischer, Beth Reagan, Alison J. Moskowitz, Fei Wan, Ying Huang, Kasey Hutt, Edgar Vigil, Meredith Olson, Austin Jacobsen, Steven M. Horwitz
Journal: Blood (2020)
RUNX1 Enhances Leukemia Cell Engraftment in the Vascular Niche through up-Regulating E-Selectin
Authors: Chieko Tokushige, Ken Morita, Shintaro Maeda, Hiroki Kiyose, Mina Noura, Tatsuki Kataoka, Toshikazu Bando, Hiroshi Sugiyama, Yasuhiko Kamikubo, Souichi Adachi
Journal: Blood (2017)
Utilization &amp; Barriers to Curative Therapies Among Adult Aplastic Anemia Patients in a Multiethnic Urban Underserved Cohort
Authors: Rose Snyder, Christopher Leyton, Richard Elkind, Sireesha Vutukuri, Rosmi Mathew, Ioannis Mantzaris, Mendel Goldfinger, Noah Kornblum, Kira Gritsman, Amit Verma, Lizamarie Bachier Rodriguez, R. Alejandro Sica, Ira Braunschweig, Aditi Shastri
Journal: Blood (2020)
The Final Analysis of Expand: A Phase 1b, Open-Label, Dose-Finding Study of Ruxolitinib (RUX) in Patients (pts) with Myelofibrosis (MF) and Low Platelet (PLT) Count (50 × 109/L to &amp;lt; 100 × 109/L) at Baseline
Authors: Paola Guglielmelli, Jean-Jacques Kiladjian, Alessandro M. Vannucchi, Ming-hui Duan, Haitao Meng, Ling Pan, Guangsheng He, Srdan Verstovsek, Françoise Boyer-Perrard, Fiorenza Barraco, Dietger Niederwieser, Anna Marina Liberati, Claire Harrison, Pantelia Roussou, Monika Wroclawska, Kevin Majidi, Peter AW te Boekhorst, Heinz Gisslinger
Journal: Blood (2020)
20-Year Follow-up of Two Cases of Bilateral Hand Transplantation
Authors: Stefan Schneeberger, Palmina Petruzzo, Emmanuel Morelon, Theresa Hautz, Jean Kanitakis, Annemarie Weissenbacher, Franka Messner, Laurence Bernardon, Christian Seulin, Valeria Berchtold, Marina Ninkovic, Dietmar Öfner, Lionel Badet, Aram Gazarian, Marco Lanzetta, Raimund Margreiter, Jean-Michel Dubernard
Journal: New England Journal of Medicine (2020)

20-Year Follow-up of Two Patients with Bilateral Hand Transplants This letter reports the 20-year results in two men who underwent bilateral hand transplantation. Each of the patients can perform a...
Impact of Hemoglobin Level As a Continuous Variable in Calculating Prognosis in MDS: Incorporation into LSC4 and IPSS-R
Authors: Faezeh Darbaniyan, Guillermo Montalban Bravo, Yue Wei, Rashmi Kanagal-Shamanna, Koji Sasaki, Hui Yang, Kelly A. Soltysiak, Kelly S. Chien, Kim-Anh Do, Guillermo Garcia-Manero
Journal: Blood (2020)
The Toll of Lockdown Against COVID-19 on Diabetes Outpatient Care: Analysis From an Outbreak Area in Northeast Italy
Authors: Benedetta Maria Bonora, Mario Luca Morieri, Angelo Avogaro, Gian Paolo Fadini
Journal: Diabetes Care (2020)

After the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from China, Italy became the second most affected country. One of the first outbreaks started in the municipality of Vo’ in the Padua province of the Veneto region. The area was quarantined, and most residents with symptomatic coronavirus disease 2019 (COVID-19) were admitted to the Padua Hospital. Due to escalating numbers of cases, lockdown measures were imposed at a national level. Along with mass testing, such interventions helped with restraining SARS-CoV-2 diffusion (1). During lockdown, hospitals reorganized to care for COVID-19 patients. From 15 March 2020, outpatient visits were limited to nondeferrable ones, while other appointments were switched to telemedicine, postponed, or cancelled.

Diabetes is a key risk factor for severe COVID-19 (2), but the impact of lockdown on diabetes care is less appreciated. We analyzed the outpatient clinic database of the Padua Hospital, containing routine clinical data on demographics, anthropometrics, laboratory results, complications, and therapies. Patients had provided written informed consent for the reuse of anonymized data for research purposes. In agreement with national regulation, the local ethics committee (Padua, Italy) was notified of the protocol. …
Abstract MP123: The Fate and Role of Pericytes in Repair and Remodeling of the Infarcted Heart
Authors: Linda Alex, Ya Su, Nikolaos G Frangogiannis
Journal: Circulation Research (2020)

Repair of the infarcted heart is dependent on inflammation-driven activation of myofibroblasts (MFs) and subsequent formation of a scar. Though pericytes have been implicated in injury-associated fibroblast activation in several organs, their potential role in cardiac repair and fibrosis has not been studied. We hypothesized that myocardial infarction (MI) may induce pericyte activation, contributing to repair through pericyte to MF conversion, secretion of fibrogenic mediators, or regulation of angiogenesis. In order to test the hypothesis, we generated pericyte/fibroblast reporter mice (NG2 DsRed ;PDGFRα GFP ). In normal myocardium, NG2 labeled peri-endothelial mural cells that coexpressed PDGFRβ, whereas PDGFRα identified interstitial cells with fibroblast characteristics. Pericytes and fibroblasts had distinct transcriptomic profiles: NG2+/PDGFRα- pericytes expressed αSMA and low amounts of extracellular matrix (ECM) genes, whereas PDGFRα+/NG2- fibroblasts synthesized collagens. Pericyte rarefaction was noted in the necrotic core 3 days after non-reperfused MI. 3-7 days post MI, expansion of the NG2+ population in the infarct zone was associated with emergence of non-mural NG2+/αSMA+ cells with MF characteristics. FACS-sorted NG2+/PDGFRα- cells from 7-day infarcts expressed higher levels of ColIα2 (7.2±1.0-fold) and ColIIIα1 (8.9±1.14-fold), when compared to NG2+/PDGFRα- cells from normal hearts. NG2+ cells had high mRNA levels of integrins α1, αV, β1, and β5, and of MMP14, reflecting an activated migratory phenotype. To examine whether expression of ECM genes by infarct pericytes is due to fibroblast conversion, we did lineage tracing studies using NG2CreER TM ;Rosa tdTomato mice bred with the PDGFRα GFP line for reliable fibroblast identification. 7 days post MI, 5.7%±1.04 of PDGFRα+ fibroblasts were derived from NG2+ cells. Also, αSMA staining showed that 10.49%±2.73 of infarct MFs were derived from NG2+ lineage. The majority of mural cells wrapping neovessels were derived from NG2+ cells, suggesting a role for resident pericytes in infarct angiogenesis. In conclusion, upon MI, pericytes become activated and contribute to repair by undergoing conversion to a subset of myofibroblasts and by coating infarct neovessels.
Endocytosis-Mediated Replenishment of Amino Acids Favors Cancer Cell Proliferation and Survival in Chromophobe Renal Cell Carcinoma
Authors: Yi Xiao, Anja Rabien, René Buschow, Vyacheslav Amtislavskiy, Jonas Busch, Ergin Kilic, Sonia L. Villegas, Bernd Timmermann, Moritz Schütte, Thorsten Mielke, Marie-Laure Yaspo, Klaus Jung, David Meierhofer
Journal: Cancer Research (2020)

Abstract Chromophobe renal cell carcinoma (chRCC) accounts for approximately 5% of all renal cancers and around 30% of chRCC cases have mutations in TP53. chRCC is poorly supported by microvessels and has markably lower glucose uptake than clear cell RCC and papillary RCC. Currently, the metabolic status and mechanisms by which this tumor adapts to nutrient-poor microenvironments remain to be investigated. In this study, we performed proteome and metabolome profiling of chRCC tumors and adjacent kidney tissues and identified major metabolic alterations in chRCC tumors, including the classical Warburg effect, the downregulation of gluconeogenesis and amino acid metabolism, and the upregulation of protein degradation and endocytosis. chRCC cells depended on extracellular macromolecules as an amino acid source by activating endocytosis to sustain cell proliferation and survival. Inhibition of the phospholipase C gamma 2 (PLCG2)/inositol 1,4,5-trisphosphate (IP3)/Ca2+/protein kinase C (PKC) pathway significantly impaired the activation of endocytosis for amino acid uptakes into chRCC cells. In chRCC, whole-exome sequencing revealed that TP53 mutations were not related to expression of PLCG2 and activation of endocytosis. Our study provides novel perspectives on metabolic rewiring in chRCC and identifies the PLCG2/IP3/Ca2+/PKC axis as a potential therapeutic target in patients with chRCC. Significance: This study reveals macropinocytosis as an important process utilized by chRCC to gain extracellular nutrients in a p53-independent manner.
Moral dilemmas and trust in leaders during a global health crisis
Authors: Jim A. C. Everett, Clara Colombatto, Edmond Awad, Paulo Boggio, Björn Bos, William J. Brady, Megha Chawla, Vladimir Chituc, Dongil Chung, Moritz A. Drupp, Srishti Goel, Brit Grosskopf, Frederik Hjorth, Alissa Ji, Caleb Kealoha, Judy S. Kim, Yangfei Lin, Yina Ma, Michel André Maréchal, Federico Mancinelli, Christoph Mathys, Asmus L. Olsen, Graeme Pearce, Annayah M. B. Prosser, Niv Reggev, Nicholas Sabin, Julien Senn, Yeon Soon Shin, Walter Sinnott-Armstrong, Hallgeir Sjåstad, Madelijn Strick, Sunhae Sul, Lars Tummers, Monique Turner, Hongbo Yu, Yoonseo Zoh, Molly J. Crockett
Journal: Nature Human Behaviour (2021)
Hypomagnesemia Is Associated with an Increased Risk of Failure in Patients Diffuse Large B-Cell Lymphoma Undergoing Autologous Stem Cell Transplantation
Authors: Jennifer Gile, Camden Lopez, Gordon Ruan, Matthew A Hathcock, Jithma P. Abeykoon, M Molly McMahon, Jose C Villasboas, Luis F. Porrata, Stephen M. Ansell, William J Hogan, Thomas E. Witzig
Journal: Blood (2020)
Final Results from a Phase II Study Combining Azacitidine and Pembrolizumab in Patients with Higher-Risk Myelodysplastic Syndrome after Failure of Hypomethylating Agent Therapy
Authors: Kelly S. Chien, Gautam Borthakur, Kiran Naqvi, Naval Daver, Guillermo Montalban Bravo, Jorge E. Cortes, Courtney D. DiNardo, Elias Jabbour, Yesid Alvarado, Michael Andreeff, Prithviraj Bose, Nitin Jain, Kimberly Sheppard, Cheri Klingner-Winton, Sherry A. Pierce, Xiao Qin Dong, Kelly A. Soltysiak, Hagop M. Kantarjian, Guillermo Garcia-Manero
Journal: Blood (2020)
Low-Dose Decitabine Plus Venetoclax Maintenance Therapy Can Decrease the Relapse after Allogeneic Stem Cell Transplantation for MRD Positive High-Risk Acute Myeloid Leukemia and Myelodysplastic Syndrome
Authors: Yunxiong Wei, Yaqing Cao, Xin Jin, Xiaoyuan He, Rui Sun, Xia Xiong, Wenyi Lu, Xin Li, Xia Xiao, Hairong Lyu, Mingfeng Zhao
Journal: Blood (2020)
Abstract PO-060: COVID-CANCER HUIL STUDY: Registry of oncologic patients diagnosed with Covid-19 in Infanta Leonor University Hospital in Madrid, Spain
Authors: Jacobo Rogado, Berta Obispo, Gloria Serrano-Montero, Almudena Martin Merino, Ana Lopez-Alfonso, Cristina Pangua, Mar Pérez-Pérez, Mario Fontán-Vela, Miguel Ángel Lara
Journal: Clinical Cancer Research (2020)

Abstract Background: Covid-19 has been shown to present more complications in immunosuppressed patients. We determine whether differences exist in Covid-19-related mortality between cancer patients and general population in our hospital, and we also describe associated risk factors. Methods: We reviewed 2,216 medical records of all patients admitted to hospitalization in Infanta Leonor University Hospital in Madrid, Spain, with Covid-19 diagnosis between 5 March and 13 May, 2020. Study data were collected and managed using REDCap electronic data capture tools. We described Covid-19 cumulative incidence in cancer patients, treatment outcome, mortality, and associated risk factors. Results: We detected 85/2,216 cancer patients between all Covid-19 diagnoses. Mortality rate: 40/85 cancer patients vs. 260/2,131 in general ward (p&amp;lt;0.001). Median age: 76 years old (34-94), 50/85 male patients. Most frequent histologies were lung cancer (22/85), colorectal cancer (19/85), prostate cancer (15/85), and breast cancer (10/85). Most frequent staging was metastatic disease (32/85). Only 2/85 patients were admitted to ICU. Mortality was associated with older median age (79.5 vs. 73, p=0.03), high d dimer levels (1630 vs. 830, p=0.03), high LDH levels (315.5 vs. 224, p=0.003), bilateral pneumonia (24/42 vs. 5/22 with unilateral pneumonia, p=0.02), ARDS (12/13 vs. 28/72 without ARDS, p&amp;lt;0.0001), and metastatic disease (20/32 metastatic vs. 20/53 non-metastatic patients, p=0.02). Differences were maintained in multivariate analyses regarding ARDS (OR 23.7, p=0.007) and metastatic disease (OR 2.5, p=0.05). Conclusions: Covid-19 had a significant mortality in cancer patients. High D dimer and LDH levels and ARDS development in elderly metastatic patients carry an elevated risk of death in cancer patients diagnosed with Covid-19. However, only 2/85 patients were admitted to ICU and these data were decisive. It is a priority to create measures to avoid Covid-19 transmission in oncologic patients. Citation Format: Jacobo Rogado, Berta Obispo, Gloria Serrano-Montero, Almudena Martin Merino, Ana Lopez-Alfonso, Cristina Pangua, Mar Pérez-Pérez, Mario Fontán-Vela, Miguel Ángel Lara. COVID-CANCER HUIL STUDY: Registry of oncologic patients diagnosed with Covid-19 in Infanta Leonor University Hospital in Madrid, Spain [abstract]. In: Proceedings of the AACR Virtual Meeting: COVID-19 and Cancer; 2020 Jul 20-22. Philadelphia (PA): AACR; Clin Cancer Res 2020;26(18_Suppl):Abstract nr PO-060.
Intensive Fludarabine, High Dose Cytarabine and Idarubicin-Based Induction for Younger NPM1-Mutated AML Patient: Overcoming the Negative Prognosis of FLT3-ITD Mutation
Authors: Paola Minetto, Anna Candoni, Fabio Guolo, Marino Clavio, Maria Elena Zannier, Maurizio Miglino, Maria Vittoria Dubbini, Anna Sicuranza, Sara Ciofini, Elisabetta Tedone, Nicoletta Colombo, Girolamo Pugliese, Filippo Ballerini, Michele Cea, Monica Bocchia, Renato Fanin, Roberto Massimo Lemoli
Journal: Blood (2020)
A Novel Clinical Risk Factor Based Scoring System to Predict the Severity of Acute Graft Versus Host Disease and Steroid Response in Resource Constrained Settings
Authors: Shiva Kumar Komaravelli, Nataraj K S, Shilpa Prabhu, Bharath RAM S, Hamza Yusuf Dalal, Aditi Shah, Monisha Harimadhavan, Sharat Damodar
Journal: Blood (2020)
Initial Results of a Phase 1 Dose Escalation Study of CPX-351 for Patients with Int-2 or High Risk IPSS Myelodysplastic Syndromes (MDS) and Chronic Myelomonocytic Leukemia (CMML) after Failure to Hypomethylating Agents
Authors: Guillermo Montalban Bravo, Elias Jabbour, Tapan M. Kadia, Farhad Ravandi, Zeev E. Estrov, Kiran Naqvi, Koji Sasaki, Kelly S. Chien, Graciela M. Nogueras González, Xiao Qin Dong, Stefan Faderl, Heather Schneider, Rosmy B. John, Hagop M. Kantarjian, Guillermo Garcia-Manero
Journal: Blood (2020)
Abstract 13284: C-Type Natriuretic Peptide (CNP) Regulates Adipogenesis, Thermogenesis and Glucose Sensitivity via Natriuretic Peptide Receptor (NPR)-C Signalling
Authors: Cristina Perez-Ternero, Aisah A Aubdool, Amie J Moyes, Adrian J Hobbs
Journal: Circulation (2019)

Introduction: The thermogenic capacity of atrial (ANP) and brain (BNP) natriuretic peptide has been recently identified. However, little is known about the role of the third member of the natriuret...
PTH-108 Sequential mri volume measurements of perianal fistulae in crohn’s disease
Authors: C Black, A Razack, S Myers, S Sebastian
Journal: Gut (2017)

Introduction  MRI scanning is an important tool in the diagnosis and assessment of perianal Crohn’s disease. We aimed to explore whether measurements of the volume of fistulous tracts on MRI at diagnosis and follow-up correlated with clinical outcomes  Method  This was a single centre pilot study. Patients with a new diagnosis of perianal Crohn’s disease on MRI were identified (n=25). 12 patients had a follow-up MRI for following multimodality treatment were included. Measurements of the length of the tract, width (3 point average),as well as a grading of the severity of associated inflammation (T2 imaging) were made by a specialist radiologist. The volume of the tract was calculated based on an approximation to the volume of a cylinder (πr2). Details of the patient’s treatment with biologics, immunomodulators, antibiotics and surgical interventions were collated, as well as an assessment of the clinical response of the perianal disease to treatment (none, partial, or complete healing).  Results  All patients had initiated, or had already received, some treatment for perianal Crohn’s disease (thiopurine n=11; antiTNFa n=11; antibiotics n=11; surgical drainage/EUA n=11). In all cases there was a decrease in the grading of inflammation around the tract suggesting some impact of medical therapy. 8 patients had a decrease in tract volume and this was greater than 50% in 7 cases. Of these patients,1 had a complete clinical response with closure of the fistula, 5 had a partial clinical response with significant symptom improvement but no closure, and 1 patient had no response. In three cases the volume of the tract increased (range 79%–214%) despite treatment. Of these patients, 2 experienced no healing whilst the 3rd patient with the smallest increase in volume experienced a partial clinical response.  Conclusion  This pilot study, using simple and readily generalizable technique for MRI measurement of perianal fistula volume in Crohn’s disease, appears to suggest that changes in fistula volume on MRI correlate with clinical outcomes. Further prospective work in a larger patient cohort adjusting for additional clinical variables is needed to confirm this observation.  Disclosure of Interest  None Declared
Abstract 463: Circadian <i>Clock</i> Disruption Promotes Cardiac Cell Death During Hypoxic Injury
Authors: Lorrie A Kirshenbaum, Inna Rabinovich, Tami A Martino
Journal: Circulation Research (2020)

Circadian rhythms play a fundamental role in cell metabolism and tissue homeostasis as well as in the diurnal oscillation of physiological processes such as blood pressure. Zeitgebers influence the circadian rhythms by serving as molecular switches for re-setting the intrinsic cellular clock. Herein, we show that oxygen is a Zeitgeber for the circadian rhythm and regulator of clock gene expression in cardiac myocytes. We further show that clock gene regulation promotes survival of cardiac myocytes by a mechanism that bi-directionally influences mitochondrial clearance and autophagy. Cardiac myocytes exhibited phasic oscillations in clock gene expression under basal conditions which was disrupted during hypoxia. This was accompanied by a marked time dependent decline in clock gene transcription that was maximal at ZT+18 and coincided with a reciprocal increase in mitochondrial clearance. Loss of function mutations of clock that disrupted nuclear localization or DNA binding to BMAL-1 promoted wide-spread cell death. Hence, the findings of the present study provide a novel signaling axis that operationally links hypoxia regulated clock gene expression and mitochondrial turn-over to cell survival.
Phase 1 Trial of Vodobatinib, a Novel Oral BCR-ABL1 Tyrosine Kinase Inhibitor (TKI): Activity in CML Chronic Phase Patients Failing TKI Therapies Including Ponatinib
Authors: Jorge E. Cortes, Tapan Saikia, Dong-Wook Kim, Yesid Alvarado, Franck E Nicolini, Navin Khattry, Krishnakumar Rathnam, Jane Apperley, Michael W. Deininger, Hugues de Lavallade, Aude Charbonnier, Nikki Granacher, Carlo Gambacorti-Passerini, Alessandro Lucchesi, Michael J. Mauro, Gregor Verhoef, Peter Vandenberghe, Andrew R. Whiteley, Shashikant Apte, Siu-Long Yao, Mudgal Kothekar, Jayasree Sreenivasan, Bimba HV, Geetanjali Chimote
Journal: Blood (2020)
The Potential Role of Emicizuamb Prophylaxis in Severe Von Willebrand Disease
Authors: Assaf Arie Barg, Gili Kenet, Tami Livnat, Einat Avishai, Ivan Budnik, Tami Brutman-Barazani, Ilia Tamarin, Aharon Lubetsky, Dalia Bashari, Rima Dardik, Shadan Lalezari, Mudi Misgav
Journal: Blood (2020)
Advanced Imaging and Targeted Myeloma Lesion Biopsies to Enhance Global Response Assessment and Evaluate Spatial Heterogeneity in Multiple Myeloma
Authors: Sabrina L. Browning, Terri L. Parker, Noffar Bar, Tara Anderson, Madhav V. Dhodapkar, Stuart Seropian, Alfred Ian Lee, Thomas Prebet, Stephanie Halene, Mina L. Xu, Elan Gorshein, Ashita Talsania, Wajih Zaheer Kidwai, David H. Witt, Victor Chang, Andrew Lischuk, Wei Wei, Andrew Haims, Natalia Neparidze
Journal: Blood (2020)
Modelling Congenital Dyserythropoietic Anemia Type II through Gene Editing in Hematopoietic Stem and Progenitor Cells
Authors: Mercedes Dessy-Rodriguez, Sara Fañanas-Baquero, Veronica Venturi, Salvador Payán-Pernía, Cristian Tornador, Gonzalo Hernandez, Mayka Sanchez, José C Segovia, Oscar Quintana Bustamante
Journal: Blood (2020)
Targeting AXL Kinase Sensitizes Acute Myeloid Leukemia Stem and Progenitor Cells to Venetoclax Treatment
Authors: Katharina Rothe, Xiaojia Niu, Min Chen, Rick Li, Sungeun Nam, Xiuyan Zhang, German Novakovskiy, Yehyeon Ahn, Shenshen Lai, Hong Zhang, Jun Yan, Hong Liu, Yun Zhao, Depei Wu, Yubin Ge, Wyeth W. Wasserman, Calvin K. Yip, Zaihui Zhang, Xiaoyan Jiang
Journal: Blood (2020)