Global burden of respiratory infections associated with seasonal influenza in children under 5 years in 2018: a systematic review and modelling study
Authors: Xin Wang, You Li, Katherine L O'Brien, Shabir A Madhi, Marc-Alain Widdowson, Peter Byass, Saad B Omer, Qalab Abbas, Asad Ali, Alberta Amu, Eduardo Azziz-Baumgartner, Quique Bassat, W Abdullah Brooks, Sandra S Chaves, Alexandria Chung, Cheryl Cohen, Marcela Echavarria, Rodrigo A Fasce, Angela Gentile, Aubree Gordon, Michelle Groome, Terho Heikkinen, Siddhivinayak Hirve, Jorge H Jara, Mark A Katz, Najwa Khuri-Bulos, Anand Krishnan, Oscar de Leon, Marilla G Lucero, John P McCracken, Ainara Mira-Iglesias, Jennifer C Moïsi, Patrick K Munywoki, Millogo Ourohiré, Fernando P Polack, Manveer Rahi, Zeba A Rasmussen, Barbara A Rath, Samir K Saha, Eric AF Simões, Viviana Sotomayor, Somsak Thamthitiwat, Florette K Treurnicht, Marylene Wamukoya, Lay-Myint Yoshida, Heather J Zar, Harry Campbell, Harish Nair, Harish Nair, Harry Campbell, Xin Wang, You Li, Alexandria Chung, Manveer Rahi, Qalab Abbas, Asad Ali, Zulfiqar A Bhutta, Bushra Saeed, Sajid B Soofi, Mohammad Tahir Yousafzai, Anita K Zaidi, Alberta Amu, Elizabeth Awini, Eduardo Azziz-Baumgartner, Henry C Baggett, Sandra S Chaves, Nong Shang, Stephanie J Schrag, Marc-Alain Widdowson, Stefano Tempia, Quique Bassat, Miguel Lanaspa, Sozinho Acácio, W Abdullah Brooks, Amanda Driscoll, Maria Deloria Knoll, Katherine L O'Brien, Christine Prosperi, Abdullah H Baqui, Luke Mullany, Peter Byass, Cheryl Cohen, Anne von Gottberg, Orienka Hellferscee, Florette K Treurnicht, Sibongile Walaza, Doli Goswami, Mustafizur Rahman, Nicholas E Connor, Shams El Arifeen, Marcela Echavarria, Débora N Marcone, Noelia Reyes, Andrea Gutierrez, Ivan Rodriguez, Olga Lopez, David Ortiz, Nathaly Gonzalez, Angela Gentile, Maria del Valle Juarez, Aubree Gordon, Clare Cutland, Michelle Groome, Shabir A Madhi, Marta C Nunes, Susan Nzenze, Terho Heikkinen, Siddhivinayak Hirve, Sanjay Juvekar, Natasha Halasa, Jorge H Jara, Chris Bernart, Mark A Katz, Ilan Gofer, Yonat Shemer Avni, Najwa Khuri-Bulos, Samir Faori, Asem Shehabi, Anand Krishnan, Rakesh Kumar, Ritvik Amarchand, Carmen L Contreras, Oscar de Leon, Maria R Lopez, John P McCracken, Herberth Maldonado, Antonio P Samayoa, Ana B Gomez, Marilla G Lucero, Leilani T Nillos, Socorro P Lupisan, Hanna Nohynek, Ainara Mira-Iglesias, Joan Puig-Barberà, Javier Díez-Domingo, Bradford D Gessner, Berthe-Marie Njanpop-Lafourcade, Jennifer C Moïsi, Haoua Tall, Patrick K Munywoki, Mwanjuma Ngama, D James Nokes, Saad B Omer, Dayna R Clark, Millogo Ourohiré, Sié Ali, Zabré Pascal, Bagagnan H Cheik, Mauricio T Caballero, Romina Libster, Fernando P Polack, Zeba A Rasmussen, Elizabeth D Thomas, Julia M Baker, Barbara A Rath, Patrick E Obermeier, MD. Hassanuzzaman, Maksuda Islam, Mohammad S Islam, Samir K Saha, Pinaki Panigrahi, Anuradha Bose, Rita Isaac, David Murdoch, Pritish Nanda, Shamim A Qazi, Danielle Hessong, Eric AF Simőes, Viviana Sotomayor, Somsak Thamthitiwat, Malinee Chittaganpitch, Halima Dawood, Catherine Kyobutungi, Marylene Wamukoya, Abdhalah K Ziraba, Lay-Myint Yoshida, Keisuke Yoshihara, Duc-Anh Dand, Minh-Nhat Le, Mark P Nicol, Heather J Zar, Shobha Broor, Mandeep Chadha, Lola Madrid, Lionel Gresh, Angel Balmaseda, Guillermina Kuan, Niteen Wairagkar, Milagritos D Tapia, Stacey L Knobler, Alfredo Barahona, Ericka Ferguson, Brunhilde Schweiger
Journal: The Lancet Global Health (2020)

Seasonal influenza virus is a common cause of acute lower respiratory infection (ALRI) in young children. In 2008, we estimated that 20 million influenza-virus-associated ALRI and 1 million influenza-virus-associated severe ALRI occurred in children under 5 years globally. Despite this substantial burden, only a few low-income and middle-income countries have adopted routine influenza vaccination policies for children and, where present, these have achieved only low or unknown levels of vaccine uptake. Moreover, the influenza burden might have changed due to the emergence and circulation of influenza A/H1N1pdm09. We aimed to incorporate new data to update estimates of the global number of cases, hospital admissions, and mortality from influenza-virus-associated respiratory infections in children under 5 years in 2018.