Prevalence surveys for podoconiosis and other neglected skin diseases: time for an integrated approach
Authors: Michael Marks, Oriol Mitja
Journal: The Lancet Global Health (2019)

Understanding of the geographical distribution of diseases is needed to inform health service design and delivery. It is also a necessary step in targeting priority areas and serves as a baseline to measure the impact of future interventions. In The Lancet Global Health, Kebede Deribe and colleagues1Deribe K Mbituyumuremyi A Cano J et al.Geographical distribution and prevalence of podoconiosis in Rwanda: a cross-sectional country-wide survey.Lancet Global Health. 2019; (published online March 26.)http://dx.doi.org/10.1016/S2214-109X(19)30072-5Summary Full Text Full Text PDF PubMed Scopus (21) Google Scholar present a large-scale nationwide prevalence survey for podoconiosis in all 30 districts across Rwanda. Podoconiosis is a neglected tropical disease and data on its prevalence and geographical distribution worldwide is scarce.2Deribe K Cano J Trueba ML Newport MJ Davey G Global epidemiology of podoconiosis: a systematic review.Plos Negl Trop Dis. 2018; 12: e0006324Crossref PubMed Scopus (44) Google Scholar Podoconiosis is a type of elephantiasis (lymphoedema) found in farming communities in the tropics and is triggered by an abnormal reaction to irritant mineral particles in volcanic soils amongst people who cannot afford shoes. The disease can be avoided by appropriate use of footwear and is treated through simple lymphoedema management measures, such as proper foot hygiene, bandaging, and exercises.3Negussie H Molla M Ngari M et al.Lymphoedema management to prevent acute dermatolymphangioadenitis in podoconiosis in northern Ethiopia (GoLBeT): a pragmatic randomised controlled trial.Lancet Glob Health. 2018; 6: e795-e803Summary Full Text Full Text PDF PubMed Scopus (41) Google Scholar As such, detection of affected and at-risk populations is vital to ensure prevention and treatment measures are available for everyone in need. The survey by Deribe and colleagues1Deribe K Mbituyumuremyi A Cano J et al.Geographical distribution and prevalence of podoconiosis in Rwanda: a cross-sectional country-wide survey.Lancet Global Health. 2019; (published online March 26.)http://dx.doi.org/10.1016/S2214-109X(19)30072-5Summary Full Text Full Text PDF PubMed Scopus (21) Google Scholar is an impressive and substantial undertaking that has been done at an almost unprecedented scale, reaching more than 1 in 10 Rwandans. Few mapping projects for any disease have been done anywhere in the world at this scale and the authors are to be congratulated for managing the logistics of such a challenge. To achieve this feat, the researchers trained 282 community health workers to do a census and screen for cases of lymphoedema before confirmation of podoconiosis by a team of expert examiners. This operational model has previously been used for other skin diseases such as leprosy and Buruli ulcer.4Amofah G Bonsu F Tetteh C et al.Buruli ulcer in Ghana: results of a national case search.Emerg Infect Dis. 2002; 8: 167-170Crossref PubMed Scopus (159) Google Scholar The study also highlights challenges involved in mapping a relatively rare disease. Around 1·3 million individuals were screened to identify 914 cases of podoconiosis. Although these diagnoses are an impressive achievement, there is also a need to reflect on how to establish effective ongoing case detection for rare conditions, which are often highly focal (geographically), outside of a research agenda. This challenge is not restricted to podoconiosis and is true of various other skin-related neglected tropical diseases, such as leprosy, yaws, Buruli ulcer, mycetoma, cutaneous leishmaniasis, and scabies.5Mitjà O Marks M Bertran L et al.Integrated control and management of Neglected Tropical Skin Diseases.Plos Negl Trop Dis. 2017; 11: e0005136Crossref PubMed Scopus (87) Google Scholar Integrated case finding through skin examination is one possible approach to identify multiple conditions in a single visit, and WHO has developed a manual to aid training of front-line health workers in recognition of the signs and symptoms of neglected skin diseases.6Hay R Fuller C Mitjà O Yotsu R Recognizing neglected tropical diseases through changes on the skin: a training guide for front-line health workers. World Health Organization, Geneva2018Google Scholar An integrated approach might target not only neglected tropical diseases, but also common skin conditions and skin health in general. Studies are needed to explore if the model of community health worker screening and expert verification can be extended to multiple diseases and to validate diagnostic algorithms and training packages that can be delivered on a large scale by health systems. Although national programmes will need to be tailored to neglected tropical diseases of the skin that prevail in a given country, there are opportunities to develop common and cross-cutting tools. Deribe and colleagues report that podoconiosis is widespread across Rwanda, with an overall prevalence of 68·5 per 100 000 people (95% CI 41·0–109·7). These findings add to a growing body of evidence that podoconiosis is a substantial public health problem. Progress with the mapping of this disease has been hampered by a scarcity of interest and investments in epidemiological surveys and by the inconsistent methodologies that have been used to assess its geographical distribution and spatial epidemiology.2Deribe K Cano J Trueba ML Newport MJ Davey G Global epidemiology of podoconiosis: a systematic review.Plos Negl Trop Dis. 2018; 12: e0006324Crossref PubMed Scopus (44) Google Scholar In May, 2017, Deribe and colleagues7Deribe K Cano J Newport MJ et al.The global atlas of podoconiosis.Lancet Glob Health. 2017; 5: e477-e479Summary Full Text Full Text PDF PubMed Scopus (25) Google Scholar announced in The Lancet Global Health the launch of a programme to develop a global atlas of podoconiosis through funding from the Wellcome Trust. They have mapped the distribution of the disease in Cameroon8Deribe K Andrew AB Cano J et al.Mapping the geographical distribution of podoconiosis in Cameroon using parasitological, serological, and clinical evidence to exclude other causes of lymphedema.Plos Negl Trop Dis. 2017; 12: e0006126Google Scholar and are in the process of mapping podoconiosis in other African countries and India. Notably, the study provides guidance for the standardised design, implementation, analysis, and reporting of podoconiosis surveys. The study describes an accurate and precise methodology that combines several developments, including the use of clear case definitions, a diagnostic algorithm,8Deribe K Andrew AB Cano J et al.Mapping the geographical distribution of podoconiosis in Cameroon using parasitological, serological, and clinical evidence to exclude other causes of lymphedema.Plos Negl Trop Dis. 2017; 12: e0006126Google Scholar the application of a grading system,9Tekola F Ayele Z Mariam DH Fuller C Davey G Development and testing of a de novo clinical staging system for podoconiosis (endemic non-filarial elephantiasis).Trop Med Int Health. 2008; 13: 1277-1283Crossref PubMed Scopus (57) Google Scholar and the adoption of validated modelling with environmental data to predict the prevalence of the disease in unsampled locations.10Deribe K Cano J Newport MJ et al.Mapping and modelling the geographical distribution and environmental limits of podoconiosis in Ethiopia.PLoS Negl Trop Dis. 2015; 9: e0003946Crossref PubMed Scopus (45) Google Scholar In 2011, podoconiosis was recognised by WHO as a neglected condition, but the disease does not appear on the 2018 list of WHO neglected tropical diseases. Owing to similarities in the clinical presentation and morbidity management strategies between lymphatic filariasis and podoconiosis, podoconiosis was previously grouped alongside the lymphatic filariasis programme. Despite this, podoconiosis is often found in different regions of countries where lymphatic filariasis is endemic and also in countries where lymphatic filariasis is not found at all (as the present study in Rwanda shows). Consequently, inadequate coverage of health interventions for people with podoconiosis is expected from programmes that are based only on the presence of lymphatic filariasis. Podoconiosis affects the poorest individuals, is easily preventable and treatable, and—as this study shows—requires a WHO programme that is separate from the Global programme to Eliminate Lymphatic Filariasis. MM is employed by the London School of Hygiene & Tropical Medicine, where authors of the linked Article are also employed. The authors work in a different department to MM and were not involved in this work. OM declares no competing interests. Geographical distribution and prevalence of podoconiosis in Rwanda: a cross-sectional country-wide surveyDespite relatively low prevalence, podoconiosis is widely distributed geographically throughout Rwanda. Many patients are likely to be undiagnosed and morbidity management is scarce. Targeted interventions through a well coordinated health system response are needed to manage those affected. Our findings should inform national level planning, monitoring, and implementation of interventions. Full-Text PDF Open Access