THU0573 COMPLICATIONS AND ACTIVITY OF UVEITIS IN A MULTIDISCIPLINARY REFERENCE UNIT IN THE NORTH OF SPAIN
Authors: Patricia Fanlo, Henar Heras, Alfredo Adan, Gerard Espinosa
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> Uveitis, an intraocular inflammatory disease, is a significant cause of visual impairment. It is not known how many patients with uveitis will retain visual acuity and how many develop visual impairment or even blindness. The activity of uveitis, the use of topic and oral steroids could produce ocular complications. <h3>Objectives</h3> To describe the complications and the activity of the uveitis in a cohort of 500 patients diagnosed in one unit of reference in the North of Spain. <h3>Methods</h3> A prospective study of complications and the activity of the 500 adults with uveitis were evaluated in the multidisciplinary Uveitis Unit of Complejo Hospitalario de Navarra from January of 2010 to March of 2015. Uveitis activity and the type of complication to the year of follow-up were analysed. The variables were collected according to the terminology of the activity of the SUN (inactive, worsening, improvement and remission). To facilitate statistical analysis variables inactive and remission were grouped in a same term. A study of characterization of the evolution and worsening of the activity to the year of follow-up with age, sex, foreign, type of uveitis, etiology, laterality, treatments and complications. The characterization was carried out through the SPAD 8 program and was carried out by contrast Chi square. <h3>Results</h3> We collected a total of 500 patients, 54.4% of patients remained inactive or in remission after 1 year of follow-up, 13.2% presented worsening of their activity and 32.45% had improved. A bivariate analysis was performed between the variable evolution per year and other variables. We díd'nt observe relationship between the evolution per year and age, sex, foreign, type of uveitis, etiology, laterality, topical etreatment, intravitreal treatment, biological treatment or surgical treatment. Relationship was found statistically significant between the evolution with the existence of complications (p = 0, 0) and oral immunosuppressive treatment (p = 0, 008). There was statistically significant relationship between the variable worsening with the existence of complications(p = 0, 0), topical eye treatment (p = 0, 035), oral immunosuppressive treatment (p = 0, 011), and not relationship with age was found (p = 0, 8), sex (p=0,35), foreign (p = 0, 27), type of uveitis (p = 0, 85), laterality (p = 0, 6) etiology (p = 0, 1), periocular treatment (p = 0, 50), intravitreal (0.56) and biologic treatment (p=0,182). 65% of the patients did not show any complication a year of follow-up and the most frequent complications were cataract (10%), synechiae (8%), macular edema (5%), glaucoma (3%), detachment of retina (3%), epiretinal membrane (2%) and other (5%). <h3>Conclusion</h3> 87% of the patients were in remission or improvement to the year of follow-up. The worsening of the uveitis is related with the existence of complications and oral immunosuppressive treatment. <h3>References</h3> [1] - D.A. Jabs, R.B. Nussenblatt, J.T. Rosenbaum, Standarization of uveitis nomenclature (SUN) Working Group Standarization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. Am J Ophthalmol. 2005; 140: 509-516 [2] - A. Rothova, M.S. Suttorp-van Schulten, W. Frits Tretters, A. Kijlstra.Causes and frequency of blindness in patients with intraocular inflammatory disease.Br J Ophthalmol.1996; 80: 332-336 [3] - Prieto-del-Cura M, González-Guijarro J. Complications of uveitis: prevalence and risk factors in a series of 398 cases.Arch Soc Esp Oftalmol. 2009;84:523-8. <h3>Disclosure of Interests</h3> Patricia Fanlo Speakers bureau: Abvie, Henar Heras : None declared, Alfredo Adan : None declared, Gerard Espinosa : None declared