AB1158 Malignancy in patients with sarcoidosis: a retrospective cohort study from turkey
Authors: S. Kobak, F. Yildiz, H. Semiz, M. Orman
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> The relationship between sarcoidosis and malignancy is not clear yet. There is debate with different speculations in the literature in this regard, that this association may be just a coincidence and/or common pathogenetic link. <h3>Objectives</h3> The goal of our study was to evaluate the incidence and characteristics of malignancy in patients with sarcoidosis follow-up in a single centre. <h3>Methods</h3> Our study is a retrospective analysis of patients diagnosed with sarcoidosis at the single Rheumatology centre from Turkey. Electronic patient records from the years 2010 to 2016 were screened, and 131patients with the diagnosis of sarcoidosis were included in the study. Diagnosis of sarcoidosis was either a clinical diagnosis in patients with Löfgren's syndrome or confirmed by tissue biopsy in all other patients. The incidence of malignancies were evaluated in this cohort. Malignant diseases were diagnosed by histopathology. The clinical data of patients with sarcoidosis and malignant diseases were further analysed. <h3>Results</h3> A total of 6 patients with malignancy were identified in our cohort of 131 patients with sarcoidosis, representing an incidence of 4.6%. Among them, Hodjkin lymphoma(HL) were detected in three patients, followed by one patient with breast cancer, one patient with thyroid cancer and one patient with testicular cancer. All patients had chronic sarcoidosis with pulmonary involvement, and only 1 patient(with thyroid cancer) had acute sarcoidosis with Löfgren's syndrome. HL developed concomitantly with sarcoidosis in one patient while other two patients developed disease before and after sarcoidosis diagnosis. Two patients with solid tumours (breast Ca, testicular Ca) developed malignancy years before sarcoidosis diagnosis(1 year and 2 year espectively), while one patient developed thyroid cancer during sarcoidosis follow-up. All 6sarcoidosis-malignancy patients were survived during six year follow-up. <h3>Conclusions</h3> We found low incidence of malignancy in patients with sarcoidosis in our small cohort. Malignancy may develop in patients with sarcoidosis. Its may occur before, after, or concurrent with the diagnosis of sarcoidosis. The sarcoidosis-malignancy relationship can only be a coincidence and/or can be explained by a common pathogenesis. New prospective studies involving large patients series are needed in this regard. <h3>References</h3> [1] Chen ES, Moller DR. Etiology of sarcoidosis. Clin Chest Med. 2008; 29:365–377. [2] Iannuzzi MC, Fontana JR. Sarcoidosis: clinical presentation, immunopathogenesis, and therapeutics. J Am Med Assoc. 2011;305:391–9. [3] Baughman RP, Teirstein AS, Judson MA, Rossman MD, Yeager H Jr, Bresnitz EA, et al. Clinical characteristics of patients in a case control study of sarcoidosis. Am J Respir Crit Care Med.2001;164:1885–9. [4] Reich JM, Mullooly JP, Johnson RE. Linkage analysis of malignancy-associated sarcoidosis. Chest1995;107(3):605–13. [5] Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature2008; 454:436–444. <h3>Disclosure of Interest</h3> None declared