FRI0478 SPINAL MOBILITY AND BONE MINERAL DENSITY IN SPONDYLOARTHRITIS
Authors: Laura Bautista, Asunción Salmoral, Inmaculada Gómez Gracia, Ladehesa Pineda Lourdes, Pérez Sánchez Laura, Gómez García Ignacio, Inmaculada Concepcion Aranda-Valera, Maria del Carmen Abalos-Aguilera, Garrido Castro Juan Luis, Font Ugalde Pilar, María del Carmen Castro Villegas, Alejandro Escudero Contreras, Eduardo Collantes Estevez
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> Osteoporosis is the most frequent comorbidity in axial spondyloartritis (axSpA). The change in spinal mobility (traditional measures) in patients with axSpA has been associated with low bone mineral density (BMD) although the data are variable (DIM, lateral flexion, BASMI). <h3>Objectives</h3> The aim of our study is to understand the relationship between spinal mobility, BMD and fragility fractures. <h3>Methods</h3> Analytical, observational, longitudinal, and retrospective study of a cohort of patients with axSpA (ASAS criteria). Perimenopausal or menopausal women, diseases and/or osteopening treatments, biological drugs, immunosuppressive drugs (at least one year before), and treatment with drugs that interfere in the bone metabolism were excluded; bisphosphonates, ranelate of strontium, selective modulators of the estrogen receptor, calcitonin, hormone therapy, denosumab and teriparatide, among others. <h3>Results</h3> 74 patients were studied, 67 were clasified as axSpA and 7 as peripheral SpA. Bivariate analysis showed that the group of patients with osteoporosis (14,86%) had a worse DIM (p = 0.001), tragus-to-wall distance (p = 0.001) and lateral flexion (p = 0.045) than patients who did not have osteoporosis. The multiple regression analysis indicated that lumbar spine t/zscore was independently associated with BASMI index (B 0,682, p=0,013), femoral neck t/zscore was independently associated with BASFI index (B 1,575, p=0,007) and with lower levels of 25 OH vitamin D (B 0,895, p=0,028). <h3>Conclusion</h3> UCOASMI is a validated metrological index with three-dimensional measurements of human spinal mobility that shows higher levels of objectivity and precision than traditional measures. Subsequent studies will compare mobility parameters (UCOASMI) and BMD of patients with axSpA. Clarifyng the relationship between spinal mobility, BMD and fragility fractures would help us to better understand the course of the disease in axSpA. <h3>References</h3> [1] Moltó A, et al. Ann Rheum Dis. 2016Jun;75(6):1016-23. [2] Weijden MA,et al. Clin Rheumatol. 2011;30(4):497–503. [3] Venceviciene, et al. Medicine,2015; 51(5): 272-279 <h3>Disclosure of Interests</h3> Laura Bautista: None declared, Asunción Salmoral: None declared, Inmaculada Gómez Gracia: None declared, Ladehesa Pineda Lourdes: None declared, Pérez Sánchez Laura: None declared, Gómez García Ignacio: None declared, Inmaculada Concepcion Aranda-Valera: None declared, Maria del Carmen Abalos-Aguilera: None declared, Garrido Castro Juan Luis: None declared, Font Ugalde Pilar: None declared, María del Carmen Castro Villegas Paid instructor for: MSD, Abbvie, Pfizer, Janssen, Lilly, Roche, Alejandro Escudero Contreras: None declared, Eduardo Collantes Estevez: None declared