tbuckley/cabot-search huggingface dataset:
Association Between State-Level Criminal Justice–Focused Prenatal Substance Use Policies in the US and Substance Use–Related Foster Care Admissions and Family Reunification
Authors: Maria X. Sanmartin, Mir M. Ali, Sean Lynch, Arda Aktas
Journal: JAMA Pediatrics (2020)

States have enacted criminal justice-related substance use policies to address prenatal substance use and protect infants from adverse health effects of parental substance use. However, little is known about the consequences of these policies for permanency outcomes among infants in the foster care system in the United States.To evaluate the consequences of criminal justice-related prenatal substance use policies for family reunification and to examine differences in parental reunification by racial/ethnic group.In this cohort study using data from the 2005 to 2017 Adoption and Foster Care Analysis and Reporting System, 13 cohorts of infants who entered the foster care system were followed up. States with criminal justice-related prenatal substance use policies were compared with states without such policies before and after their enactment using a discrete-time hazard model adjusted for individual covariates, state, and cohort fixed effects. The sample consisted of 350 604 infants 1 year or younger who had been removed from their home because of parental drug or alcohol use.Length of time from entering the child welfare system to first reunification with a parent and hazard rates (HRs).Of the 350 604 infants 1 year or younger, 182 314 (52%) were boys, 251 572 (72%) were non-Hispanic white children, and 160 927 (46%) lived in US states with a criminal justice-focused prenatal substance use policy. Among those who were reunified, 36% of the reunifications occurred during the first year and 45% in the second year. Foster care infants who were removed from their homes because of parental substance use who live in states that have adopted criminal justice-oriented policies had a lower chance of reunification with a parent compared with states that have not adopted those policies (HR, 0.95; 95% CI, 0.94-0.96). Specifically, non-Hispanic black children who live in a state that has adopted criminal justice-oriented policies had a lower chance of reunification with a parent than non-Hispanic black children who live in a state that has not adopted those policies (HR, 0.87; 95% CI, 0.81-0.94).Given the child welfare system's legal mandate to make every effort toward parental reunification, a more comprehensive treatment and supportive policy approach toward parental substance use might be warranted.
COMPLEX ANTITHROMBOTIC THERAPY IN PATIENTS WITH ACUTE LOWER GASTROINTESTINAL BLEEDING: CLINICAL OUTCOMES
Authors: S Mashlab, P Garcia - Iglesias, E Martinez-Bauer, A Soria, J Vives, M Raurich, S Marin, F Junquera, V Puig-Divi, X Calvet, R Campo, E Brullet, A Lira
Journal: Endoscopy (2020)

Aims Analyze the relationship of CAT (dual treatment: antiplatelet-anticoagulant or antiplatelet-antiplatelet) and the adverse outcomes in patients with acute lower gastrointestinal bleeding (LGB).
Global Burden of Atherosclerotic Cardiovascular Disease in People Living With HIV
Authors: Anoop S.V. Shah, Dominik Stelzle, Kuan Ken Lee, Eduard J. Beck, Shirjel Alam, Sarah Clifford, Chris T. Longenecker, Fiona Strachan, Shashwatee Bagchi, William Whiteley, Sanjay Rajagopalan, Shyamasundaran Kottilil, Harish Nair, David E. Newby, David A. McAllister, Nicholas L. Mills
Journal: Circulation (2018)

With advances in antiretroviral therapy, most deaths in people with HIV are now attributable to noncommunicable illnesses, especially cardiovascular disease. We determine the association between HIV and cardiovascular disease, and estimate the national, regional, and global burden of cardiovascular disease attributable to HIV. We conducted a systematic review across 5 databases from inception to August 2016 for longitudinal studies of cardiovascular disease in HIV infection. A random-effects meta-analysis across 80 studies was used to derive the pooled rate and risk of cardiovascular disease in people living with HIV. We then estimated the temporal changes in the population-attributable fraction and disability-adjusted life-years (DALYs) from HIV-associated cardiovascular disease from 1990 to 2015 at a regional and global level. National cardiovascular DALYs associated with HIV for 2015 were derived for 154 of the 193 United Nations member states. The main outcome measure was the pooled estimate of the rate and risk of cardiovascular disease in people living with HIV and the national, regional, and global estimates of DALYs from cardiovascular disease associated with HIV. In 793 635 people living with HIV and a total follow-up of 3.5 million person-years, the crude rate of cardiovascular disease was 61.8 (95% CI, 45.8-83.4) per 10 000 person-years. In comparison with individuals without HIV, the risk ratio for cardiovascular disease was 2.16 (95% CI, 1.68-2.77). Over the past 26 years, the global population-attributable fraction from cardiovascular disease attributable to HIV increased from 0.36% (95% CI, 0.21%-0.56%) to 0.92% (95% CI, 0.55%-1.41%), and DALYs increased from 0.74 (95% CI, 0.44-1.16) to 2.57 (95% CI, 1.53-3.92) million. There was marked regional variation with most DALYs lost in sub-Saharan Africa (0.87 million, 95% CI, 0.43-1.70) and the Asia Pacific (0.39 million, 95% CI, 0.23-0.62) regions. The highest population-attributable fraction and burden were observed in Swaziland, Botswana, and Lesotho. People living with HIV are twice as likely to develop cardiovascular disease. The global burden of HIV-associated cardiovascular disease has tripled over the past 2 decades and is now responsible for 2.6 million DALYs per annum with the greatest impact in sub-Saharan Africa and the Asia Pacific regions. URL: https://www.crd.york.ac.uk/prospero . Unique identifier: CRD42016048257.
ENDOSCOPIC STRICTUROTOMY - A NOVEL THERAPEUTIC MODALITY FOR IBD-RELATED STRICTURES: FIRST EUROPEAN EXPERIENCE
Authors: M Lukas, M Bortlik, M Kolar, V Pesinova, M Lukas
Journal: Endoscopy (2020)

Aims Strictures, both primary and secondary anastomotic strictures, are common complications in patients with inflammatory bowel diseases (IBD) especially Crohn´s disease (CD). Balloon dilation has been the gold standard in the endoscopic treatment of these strictures. Endoscopic stricturotomy (ESt) represent a promising novel approach, however, the data published on this method so far is limited to a single US center.
Response to: ‘External validation of EULAR/ACR classification criteria for idiopathic inflammatory myopathies’ by Luu<i>et al</i>
Authors: Masatoshi Jinnin, Akiko Ohta, Hitoshi Kohsaka
Journal: Annals of the Rheumatic Diseases (2020)

Response to: 'External validation of EULAR/ACR classification criteria for idiopathic inflammatory myopathies
CLINICAL PRACTICE PATTERNS OF INDIRECT PERORAL CHOLANGIOPANCREATOSCOPY: AN INTERNATIONAL SURVEY
Authors: P Stassen, PJ de Jonge, M Ellrichmann, A Dormann, M Udd, G Webster, M Bruno, V Cennamo
Journal: Endoscopy (2020)

Aims Indirect peroral cholangiopancreatoscopy (IPOC) is a new diagnostic and therapeutic tool for biliopancreatic diseases. Little is known about its use in daily clinical practice. We conducted an international survey to evaluate differences in use of IPOC between endoscopists from various countries.
Shared proteomic effects of cerebral atherosclerosis and Alzheimer’s disease on the human brain
Authors: Aliza P. Wingo, Wen Fan, Duc M. Duong, Ekaterina S. Gerasimov, Eric B. Dammer, Yue Liu, Nadia V. Harerimana, Bartholomew White, Madhav Thambisetty, Juan C. Troncoso, Namhee Kim, Julie A. Schneider, Ihab M. Hajjar, James J. Lah, David A. Bennett, Nicholas T. Seyfried, Allan I. Levey, Thomas S. Wingo
Journal: Nature Neuroscience (2020)
Abstract 17937: Distinct Genetic Modifiers of Heart and Muscle Fibrosis in Muscular Dystrophy Revealed by Whole Genome Scan
Authors: Kayleigh A Swaggart, Ahlke Heydemann, Abraham A Palmer, Elizabeth M McNally
Journal: Circulation (2010)

Background: Mutations in a number of different single genes lead to cardiomyopathy and muscular dystrophy. Despite identical gene mutations, there is often significant variability in human patients...
Treatment Guidance for Patients With Lung Cancer During the Coronavirus 2019 Pandemic
Authors: Anne-Marie C. Dingemans, Ross A. Soo, Abdul Rahman Jazieh, Shawn J. Rice, Young Tae Kim, Lynette L.S. Teo, Graham W. Warren, Shu-Yuan Xiao, Egbert F. Smit, Joachim G. Aerts, Soon Ho Yoon, Giulia Veronesi, Francesco De Cobelli, Suresh S. Ramalingam, Marina C. Garassino, Murry W. Wynes, Madhusmita Behera, John Haanen, Shun Lu, Solange Peters, Myung-Ju Ahn, Giorgio V. Scagliotti, Alex A. Adjei, Chandra P. Belani
Journal: Journal of Thoracic Oncology (2020)
Modeling the Impact of Cardiopulmonary Irradiation on Overall Survival in NRG Oncology Trial RTOG 0617
Authors: Maria Thor, Joseph O. Deasy, Chen Hu, Elizabeth Gore, Voichita Bar-Ad, Clifford Robinson, Matthew Wheatley, Jung Hun Oh, Jeffrey Bogart, Yolanda I. Garces, Vivek S. Kavadi, Samir Narayan, Puneeth Iyengar, Jacob S. Witt, James W. Welsh, Cristopher D. Koprowski, James M. Larner, Ying Xiao, Jeffrey Bradley
Journal: Clinical Cancer Research (2020)

To quantitatively predict the impact of cardiopulmonary dose on overall survival (OS) after radiotherapy for locally advanced non-small cell lung cancer.We used the NRG Oncology/RTOG 0617 dataset. The model building procedure was preregistered on a public website. Patients were split between a training and a set-aside validation subset (N = 306/131). The 191 candidate variables covered disease, patient, treatment, and dose-volume characteristics from multiple cardiopulmonary substructures (atria, lung, pericardium, and ventricles), including the minimum dose to the hottest x% volume (Dx%[Gy]), mean dose of the hottest x% (MOHx%[Gy]), and minimum, mean (Mean[Gy]), and maximum dose. The model building was based on Cox regression and given 191 candidate variables; a Bonferroni-corrected P value threshold of 0.0003 was used to identify predictors. To reduce overreliance on the most highly correlated variables, stepwise multivariable analysis (MVA) was repeated on 1000 bootstrapped replicates. Multivariate sets selected in ≥10% of replicates were fit to the training subset and then averaged to generate a final model. In the validation subset, discrimination was assessed using Harrell c-index, and calibration was tested using risk group stratification.Four MVA models were identified on bootstrap. The averaged model included atria D45%[Gy], lung Mean[Gy], pericardium MOH55%[Gy], and ventricles MOH5%[Gy]. This model had excellent performance predicting OS in the validation subset (c = 0.89).The risk of death due to cardiopulmonary irradiation was accurately modeled, as demonstrated by predictions on the validation subset, and provides guidance on the delivery of safe thoracic radiotherapy.
Daily and Alternate-Day Corticosteroid Regimens in Treatment of Giant Cell Arteritis
Authors: Gene G. Hunder, Sheldon G. Sheps, George L. Allen, John W. Joyce
Journal: Annals of Internal Medicine (2020)

Abstract Alternate-day corticosteroid therapy was compared with two daily corticosteroid regimens for the treatment of giant cell arteritis. In a prospective study 60 patients with this disease wer...
Multimodality Imaging Demonstrates Reduced Right-Ventricular Function Independent of Pulmonary Physiology in Moderately Preterm-Born Adults
Authors: Afifah Mohamed, Pablo Lamata, Wilby Williamson, Maryam Alsharqi, Cheryl M.J. Tan, Holger Burchert, Odaro J. Huckstep, Katie Suriano, Jane M. Francis, Joana Leal Pelado, Cristiana Monteiro, Stefan Neubauer, Philip T. Levy, Paul Leeson, Adam J. Lewandowski
Journal: JACC. Cardiovascular imaging (2020)

Preterm-born individuals have altered right-ventricular (RV) structure and function in young adulthood ([1][1]). To what extent the pulmonary circulation impacts these findings remains largely unknown. However, unlike RV changes that are apparent across gestational ages of prematurity, acute and
SAFETY AND EFFICACY OF A NEW SMARTPHONE-CONTROLLED VIBRATING CAPSULE FOR CHRONIC CONSTIPATION: A RANDOMIZED CONTROLLED TRIAL
Authors: J Zhu, Y Qian, J Yu, J Pan, Z Li, Z Liao
Journal: Endoscopy (2020)

Aims Functional constipation (FC) is a functional bowel disorder, bringing huge financial burden, emotional and physical stress to patients. Recently, an innovative vibrating capsule (VC) has been developed, with the safety and efficacy in promoting defecation being elucidated in animal studies. Thus in the current study, we want to further validate the clinical application of VC in the treatment of FC.
Pleural Disease Management: Manometry-guided Thoracentesis, Optimal Drainage Regimen of Indwelling Pleural Catheters, and Talc Poudrage versus Slurry for Malignant Pleural Effusion
Authors: Andrea Mytinger, Trevor Taylor, Evgeni Gershman, Samira Shojaee
Journal: American Journal of Respiratory and Critical Care Medicine (2020)
THE ADDITION OF CASTOR OIL AS A BOOSTER IN COLON CAPSULE REGIMENS SIGNIFICANTLY IMPROVES COMPLETION RATES AND POLYP DETECTION
Authors: S Semenov, R Atiyekeogbebe, MS Ismail, S Sihag, E McCarthy, B Ryan, N Breslin, A O’Connor, D McNamara
Journal: Endoscopy (2020)

Aims Incomplete excretion rates are problematic for colon capsule endoscopy (CCE). Widely available booster regimens perform poorly. Recently published same day CCE protocol in IBD using castor oil appeared effective. Our aim was to assess the effectiveness of adding castor oil as an additional booster in our CCE practice.
Effects of Systemic Insulin Resistance on Redox State and Endothelial Nitric Oxide Bioavailability in the Human Vascular Wall
Authors: I Akoumianakis, M Margaritis, C Psarros, L Herdman, A Antonopoulos, M Petrou, G Krasopoulos, P Wohlfart, K Channon, C Antoniades
Journal: Circulation (2015)
Increasing Safe Outpatient Management of Emergency Department Patients With Pulmonary Embolism
Authors: David R. Vinson, Dustin G. Mark, Uli K. Chettipally, Jie Huang, Adina S. Rauchwerger, Mary E. Reed, James S. Lin, Mamata V. Kene, David H. Wang, Dana R. Sax, Tamara S. Pleshakov, Ian D. McLachlan, Cyrus K. Yamin, Andrew R. Elms, Hilary R. Iskin, Ridhima Vemula, Donald M. Yealy, Dustin W. Ballard
Journal: Annals of Internal Medicine (2018)

Despite the well-established safety of outpatient treatment for pulmonary embolism in appropriately selected, low-risk patients, most of these patients continue to be hospitalized to start treatmen...
Response to topical corticosteroid monotherapy in mycosis fungoides
Authors: Saritha Kartan, Doaa Shalabi, Megan O'Donnell, Seyfettin Onder Alpdogan, Joya Sahu, Wenyin Shi, Pierluigi Porcu, Jisun Cha, Neda Nikbakht
Journal: Journal of the American Academy of Dermatology (2020)
Iron Chelation in Transfusion-Dependent Patients With Low- to Intermediate-1–Risk Myelodysplastic Syndromes
Authors: Emanuele Angelucci, Peter Greenberg, Miguel Izquierdo, Guillermo Garcia-Manero
Journal: Annals of Internal Medicine (2020)

Letters6 October 2020Iron Chelation in Transfusion-Dependent Patients With Low- to Intermediate-1–Risk Myelodysplastic SyndromesEmanuele Angelucci, MD, Peter Greenberg, MD, Miguel Izquierdo, MD, and Guillermo Garcia-Manero, MDEmanuele Angelucci, MDIRCCS Ospedale Policlinico San Martino, Genova, Italy (E.A.), Peter Greenberg, MDStanford University Medical Center, Stanford, California (P.G.), Miguel Izquierdo, MDNovartis Pharma AG, Basel, Switzerland (M.I.), and Guillermo Garcia-Manero, MDMD Anderson Cancer Center and University of Texas, Houston, Texas (G.G.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L20-1056 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We thank Dr. Lucijanic and colleagues for their comments and agree that challenges in implementation of the TELESTO trial hampered our ability to draw definitive conclusions, particularly for the longer-term outcomes. As they note, our study found that a higher proportion of patients in the placebo group discontinued their assigned treatment and received subsequent ICT. We interpreted this to reflect positively on the active deferasirox treatment group. Dr. Lucijanic and colleagues raise concern that this may not be the case, because the difference in EFS was driven by late-occurring events during a period when the placebo group was ... Author, Article, and Disclosure InformationAffiliations: IRCCS Ospedale Policlinico San Martino, Genova, Italy (E.A.)Stanford University Medical Center, Stanford, California (P.G.)Novartis Pharma AG, Basel, Switzerland (M.I.)MD Anderson Cancer Center and University of Texas, Houston, Texas (G.G.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M19-3692. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoIron Chelation in Transfusion-Dependent Patients With Low- to Intermediate-1–Risk Myelodysplastic Syndromes Emanuele Angelucci , Junmin Li , Peter Greenberg , Depei Wu , Ming Hou , Efreen Horacio Montaňo Figueroa , Maria Guadalupe Rodriguez , Xunwei Dong , Jagannath Ghosh , Miguel Izquierdo , Guillermo Garcia-Manero , and Iron Chelation in Transfusion-Dependent Patients With Low- to Intermediate-1–Risk Myelodysplastic Syndromes Marko Lucijanic , Miran Lovrinov , and Marko Skelin Metrics Cited byTargeting low-risk myelodysplastic syndrome with novel therapeutic strategiesMyelodysplastic Syndromes in the Postgenomic Era and Future Perspectives for Precision Medicine 6 October 2020Volume 173, Issue 7Page: 595-596KeywordsDisclosureFerritinMyelodysplastic syndromesPatientsSerum ferritin levelsSurvival analysis ePublished: 6 October 2020 Issue Published: 6 October 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
PHOTODYNAMIC THERAPY IN THE TREATMENT OF ESOPHAGEAL CANCER
Authors: E Stranadko, V Shabarov, M Riabov, V Duvansky
Journal: Endoscopy (2020)

Aims Esophageal cancer is characterized by poor prognosis. In the majority of cases radical operation cannot be performed due to tumor spread and concomitant diseases of age. Only 10% of patients receive surgical resection, providing 5-year survival only in 25%. Dysphagia is the main symptom of esophageal obstruction, which leads to poor quality and shortage of patients’ life. Photodynamic therapy (PDT) is a new technique, providing tumor destruction with minimal damage to surrounding tissue. Application of PDT to esophageal carcinomas is rarely reported.
THE FUNCTION OF THE COLLEGE
Journal: Annals of Internal Medicine (1938)

Article1 May 1938THE FUNCTION OF THE COLLEGEJ. H. MEANS, M.D., F.A.C.P.J. H. MEANS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-11-11-1925 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptI should like to devote the brief time available for a presidential address to a further consideration of certain questions which I put before you at the dinner last year in St. Louis, and which are also closely related to some of the problems raised by Dr. Miller in his excellent Presidential Address in Detroit, the year before that.The first of these concerns why we call ourselves a College of Physicians. Is there any special significance in the fact that we have selected the appellation College rather than that of Society or Association? What, after all, is a college... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Presidential address, delivered at the Convocation of the American College of Physicians, Twenty-Second Annual Session, New York, April 7, 1938. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1938Volume 11, Issue 11Page: 1925-1932 ePublished: 1 December 2008 Issue Published: 1 May 1938 Copyright & PermissionsCopyright, 1938, by The American College of PhysiciansPDF downloadLoading ...
Self-reported Physical Health of Women Who Did and Did Not Terminate Pregnancy After Seeking Abortion Services
Authors: Lauren J. Ralph, Eleanor Bimla Schwarz, Daniel Grossman, Diana Greene Foster
Journal: Annals of Internal Medicine (2019)

Background: Research demonstrates worse short-term morbidity and mortality associated with childbirth than with abortion, but little research has examined long-term physical health in women with unwanted pregnancies after abortion versus childbirth. Objective: To examine the physical health of women who seek and receive or are denied abortion. Design: Prospective cohort study. Setting: 30 U.S. abortion facilities from 2008 to 2010. Participants: Of 1132 women seeking abortion who consented to participate, 874 were included in this analysis (328 who had first-trimester abortion, 383 who had second-trimester abortion, and 163 who gave birth). Measurements: Self-reported overall health; chronic abdominal, pelvic, back, and joint pain; chronic headaches or migraines; obesity; asthma; gestational and nongestational hypertension and diabetes; and hyperlipidemia were assessed semiannually for 5 years. Mortality was assessed by using verbal autopsy and public records. Results: No significant differences were observed in self-rated health or chronic pain after first-trimester versus second-trimester abortion. At 5 years, 27% (95% CI, 21% to 34%) of women who gave birth reported fair or poor health compared with 20% (CI, 16% to 24%) of women who had first-trimester abortion and 21% (CI, 18% to 25%) who had second-trimester abortion. Women who gave birth also reported more chronic headaches or migraines and joint pain, but experienced similar levels of other types of chronic pain and obesity. Gestational hypertension was reported by 9.4% of participants who gave birth. Eight of 1132 participants died during follow-up, 2 in the postpartum period. Maternal mortality did not differ statistically by group. Limitation: Self-reported outcome measures, uncertain generalizability, and 41% loss to follow-up at 5 years. Conclusion: Although some argue that abortion is detrimental to women's health, these study data indicate that physical health is no worse in women who sought and underwent abortion than in women who were denied abortion. Indeed, differences emerged suggesting worse health among those who gave birth. Primary Funding Source: An anonymous foundation.
Preoperative Screening of Colorectal Cancers Is As Accurate As Postoperative Screening for Detection of Lynch Syndrome
Authors: Jack Harrigan, Christian Davis, Mahak Chauhan, Daniel Buckles, Anwaar Saeed, Kevin Kennedy, Debra L. Collins, Mojtaba Olyaee, Rashna Madan, Ajay Bansal
Journal: Clinical Gastroenterology and Hepatology (2020)
Dasatinib overcomes stroma-based resistance to the FLT3 inhibitor quizartinib using multiple mechanisms
Authors: Ami B. Patel, Anthony D. Pomicter, Dongqing Yan, Anna M. Eiring, Orlando Antelope, Jonathan A. Schumacher, Todd W. Kelley, Srinivas K. Tantravahi, Tibor J. Kovacsovics, Paul J. Shami, Thomas O’Hare, Michael W. Deininger
Journal: Leukemia (2020)
MEASURES TO REDUCE POST-POLYPECTOMY BLEEDING IN PEDUNCULATED POLYPS - DOES A CLIP HELP?
Authors: R Patel, S Modelina, R Hall, R Canda, K Besherdas
Journal: Endoscopy (2020)

Aims Immediate and delayed post-polypectomy bleeding (PPB) is a serious complication after endoscopic removal of large pedunculated polyps. Options to decrease risk of bleeding include injecting the stalk with adrenaline, placing clips across the stalk (before or after the polypectomy) and placement of a nylon loop around the stalk. The principle of closing a defect to reduce complications is well established but the cost effectiveness of prophylactic clipping remains controversial. There are currently no consensus guidelines. We aimed to investigate the use of endoscopic clips during polypectomy of pedunculated polyps >10mm and assess its association with PPB.