tbuckley/cabot-search huggingface dataset:
RELATIONSHIP BETWEEN SERIAL MEASUREMENTS OF LV EJECTION FRACTION AND CARDIOVASCULAR EVENTS IN PATIENTS WITH ACUTE CORONARY SYNDROME
Authors: Hyun Gyung Jang, Yoomee Kang, Jeong Yoon Jang, Jong-Hwa Ahn, Jae Seok Bae, Min Gyu Kang, Kyehwan Kim, Hyun Woong Park, Jin-Sin Koh, Yongwhi Park, Seok-Jae Hwang, Choong Hwan Kwak, Jin-Yong Hwang, Young-Hoon Jeong
Journal: Journal of the American College of Cardiology (2019)
OX40 stimulation and PD-L1 blockade synergistically augment HBV-specific CD4 T cells in patients with HBeAg-negative infection
Authors: Felix Johannes Jacobi, Katharina Wild, Maike Smits, Katharina Zoldan, Benedikt Csernalabics, Tobias Flecken, Julia Lang, Philipp Ehrenmann, Florian Emmerich, Maike Hofmann, Robert Thimme, Christoph Neumann-Haefelin, Tobias Boettler
Journal: Journal of Hepatology (2019)
Skin type differences in sun‐induced oxidative stress
Authors: S. Albrecht, S. Jung, R. Müller, J. Lademann, T. Zuberbier, L. Zastrow, C. Reble, I. Beckers, M.C. Meinke
Journal: British Journal of Dermatology (2019)

Excessive solar (sun) exposure, especially ultraviolet radiation, can lead to sunburn and increased damage to cells, called oxidative stress. This can cause skin damage such as inflammation, premature skin aging and tumour development. Statistics from the U.S. National Cancer Institute show that the number of new cases of melanoma and non‐melanoma skin cancer are rising every year. Therefore, it is important to understand the negative effects of solar radiation in skin. Beside the ultraviolet light, the visible and near infrared regions of the solar spectrum induce oxidative stress in fair skin types but data about the effects in darker skin types are missing. A German study addressed the distribution of oxidative stress in dark skin during solar irradiation and compared the results to those of fair skin types. Free radicals are a marker for (i.e. sign of) oxidative stress. The scientists measured the formation of free radicals on volunteers during solar irradiation, using technology called electron paramagnetic resonance spectroscopy. The authors found that darker skin was better protected against ultraviolet radiation than fair skin. However, darker skin types showed significantly more oxidative stress during near infrared irradiation compared to fair skin types. The oxidative stress in the near infrared is at least as high as in ultraviolet and visible spectral regions and could cause skin damage in darker skin. The results show that individuals of darker skin might need a different type of sun protection than those of paler skin to avoid long term damage by solar radiation.
LEFT VENTRICULAR EJECTION FRACTION TRAJECTORIES IN ACUTE DECOMPENSATED SYSTOLIC HEART FAILURE IS ASSOCIATED WITH ADVERSE OUTCOMES
Authors: Sula Mazimba, Douglas Sawch, Anita Barber, Sthuthi David, Corey Benjamin, Nora Tolbert, Patrick Stafford, Pricilla Baafi, James Bergin, Jamie Kennedy, Mohammad Abuannadi, Younghoon Kwon, Kenneth Bilchick
Journal: Journal of the American College of Cardiology (2019)
MORTALITY PREDICTION FOR OLDER ADULTS WITH AMI: THE SILVER-AMI STUDY
Authors: John A. Dodson, Alexandra Hajduk, Mary Geda, Harlan M. Krumholz, Terrence Murphy, Sui Tsang, Mary Tinetti, Michael Nanna, Richard McNamara, Thomas Gill, Sarwat Chaudhry
Journal: Journal of the American College of Cardiology (2019)
Serum levels of DNAJB9 are elevated in fibrillary glomerulonephritis patients
Authors: Samih H. Nasr, Surendra Dasari, John C. Lieske, Linda M. Benson, Patrick M. Vanderboom, Carrie J. Holtz-Heppelmann, Callen D. Giesen, Melissa R. Snyder, Stephen B. Erickson, Fernando C. Fervenza, Nelson Leung, Paul J. Kurtin, Mariam P. Alexander
Journal: Kidney International (2019)
CORONARY ARTERY BYPASS GRAFT SURGERY VERSUS PERCUTANEOUS CORONARY INTERVENTION IN WOMEN WITH MULTI VESSEL CORONARY ARTERY DISEASE
Authors: Hassan Alkhawam, Preetham Reddy Muskula, Elsayed Abo-Salem, Mohammed Al-Sadawi, James Ampadu, Mohammad Salloum, Joseph J. Lieber, Michael Lim, Tarek Helmy
Journal: Journal of the American College of Cardiology (2019)
COGNITIVE IMPAIRMENT IS A PREDICTOR OF ONE-YEAR MORTALITY IN PATIENTS REFERRED FOR CARDIAC CATHETERIZATION
Authors: Mohammed Al-Hijji, Amrit Kanwar, S. Gharacholou, Garrett Welle, Rajiv Gulati, Robert Widmer, Abdallah El Sabbagh, Ryan Lennon, Amir Lerman, Mandeep Singh
Journal: Journal of the American College of Cardiology (2019)
Genome-scale network model of metabolism and histone acetylation reveals metabolic dependencies of histone deacetylase inhibitors
Authors: Fangzhou Shen, Luigi Boccuto, Rini Pauly, Sujata Srikanth, Sriram Chandrasekaran
Journal: Genome biology (2019)

Histone acetylation plays a central role in gene regulation and is sensitive to the levels of metabolic intermediates. However, predicting the impact of metabolic alterations on acetylation in pathological conditions is a significant challenge. Here, we present a genome-scale network model that predicts the impact of nutritional environment and genetic alterations on histone acetylation. It identifies cell types that are sensitive to histone deacetylase inhibitors based on their metabolic state, and we validate metabolites that alter drug sensitivity. Our model provides a mechanistic framework for predicting how metabolic perturbations contribute to epigenetic changes and sensitivity to deacetylase inhibitors.
IMPACT OF ATRIAL FIBRILLATION ON IN-HOSPITAL OUTCOMES OF INFARCTION-RELATED CARDIOGENIC SHOCK REQUIRING PERCUTANEOUS VENTRICULAR ASSIST DEVICE (IMPELLA®) SUPPORT: A PROPENSITY-MATCHED ANALYSIS OF THE NATIONAL INPATIENT SAMPLE (NIS)
Authors: Sonu Gupta, Rupak Desai, Abhishek Deshmukh, Saraschandra Vallabhajosyula, Rushikkumar Bhuva, Gautam Kumar, Adam Berman, Rajesh Sachdeva
Journal: Journal of the American College of Cardiology (2019)
GENDER DIFFERENCE IN LONG-TERM OUTCOMES AMONG ACUTE MYOCARDIAL INFARCTION PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION
Authors: Jae-Sik Jang, Tae-Hyun Yang, Dae-Kyeong Kim, Dong-Soo Kim, Eun-Ji Park, Yeong-Ju Jeong
Journal: Journal of the American College of Cardiology (2019)
PREVALENCE AND SIGNIFICANCE OF BRADY-ARRHYTHMIAS DETECTED BY EXTENDED HEART RHYTHM RECORDING AMONG PATIENTS WITH SEVERE AORTIC STENOSIS BEFORE UNDERGOING TRANSCATHETER AORTIC VALVE REPLACEMENT (BRADY-TAVR STUDY)
Authors: Khaldoun G. Tarakji, Amar Krishnaswamy, Ayman Hussein, Stephanie Mick, Walid Saliba, Jose Navia, Kathy Wolski, Lars Svensson, Oussama Wazni, Samir Kapadia
Journal: Journal of the American College of Cardiology (2019)
Ras-Driven B-Cell Transformation Targets Developmental Rewiring of Cytokine to Pre-B Cell Receptor Signaling
Authors: Lai N Chan, Christian Hurtz, Huimin Geng, Franziska Auer, Zhengshan Chen, Gang Xiao, Jae-Woong Lee, Kadriye Nehir Cosgun, B Hilda Ye, Markus Muschen
Journal: Blood (2018)
Atopic dermatitis and educational attainment
Authors: J. Smirnova, L.B. Kobyletzki, M. Lindberg, Å. Svensson, S.M. Langan, S. Montgomery
Journal: British Journal of Dermatology (2019)

Atopic dermatitis (AD, often known as eczema) is a common skin disorder affecting up to 20% of children. However, our knowledge is incomplete for some long‐term effects of this condition such as educational attainment, meaning the level of education a person reaches at school, university or college. AD is usually visible, causes itching and sometimes sleeplessness, which may therefore impact on a person's education. In this study the level of education among adolescent males with and without AD was compared, as was cognitive function (brain processes that allow us to carry out tasks) and stress resilience (ability to cope with stress), using Swedish register data. The study included 234,715 men who underwent military conscription assessments aged 17‐20 years between 1969 and 1976: these assessments involved extensive physical and psychological examinations including a written cognitive function test. In total 1,673 (0.7%) had an AD diagnosis. Surprisingly, AD was not associated with reduced levels of academic attainment or cognitive function. In fact, slightly higher levels of education and cognitive function were observed and appear to be explained by men with AD having parents with a more advantaged socioeconomic position, resulting in improved educational performance. However, those with AD tended to have a lower ability to cope with stress, which has been linked with adverse mental and physical health outcomes in later adulthood.
WHEN DOES A CALCIUM SCORE EQUATE TO SECONDARY PREVENTION: INSIGHTS FROM THE CONFIRM REGISTRY
Authors: Matthew J. Budoff, Heidi Gransar, Stephan Achenbach, Mouaz Al-Mallah, Jeroen J. Bax, Daniel Berman, Filippo Cademartiri, Tracy Callister, Hyuk-Jae Chang, Benjamin Chow, Ricardo Cury, Gudrun Feuchtner, Martin Hadamitzky, Joerg Hausleiter, Philipp A. Kaufmann, Jonathon Leipsic, Yong-Jin Kim, Hugo Marques, Gianluca Pontone, Gilbert Raff, Ronen Rubinshtein, Todd Villines, Fay Lin, James Min
Journal: Journal of the American College of Cardiology (2019)
Tumor cyclooxygenase 2 controls PGE2 dependent promotion of FOXP3 expression and CD4+CD25+ T regulatory cell activities in non-small cell lung cancer
Authors: Felicita E. Baratelli, Seok-Chul Yang, Ying Lin, Li Zhu, Karen Reckamp, Brian Gardner, Ling Zhang, Min Huang, Raj K. Batra, Sherven Sharma, Steven M. Dubinett
Journal: Cancer Research (2005)

2657  Cyclooxygenase 2 (COX-2)/prostaglandin E2 (PGE2) underlies an immunosuppressive network that is important in the pathogenesis of non-small cell lung cancer (NSCLC). CD4+CD25+ T regulatory (Treg) cell activities increase in lung cancer, suppressing antitumor immune responses. The identification of molecules controlling Treg differentiation and function is important in understanding host immune responses in malignancy. Here we show that PGE2 enhances the in vitro inhibitory function of human purified CD4+CD25+ Treg cells and induces a regulatory phenotype in CD4+CD25- T cells. PGE2-treated T cells mediated inhibition of responder anti-CD3 stimulated lymphocytes in both a cell-contact dependent and independent manner. Phenotypic analysis revealed that PGE2 diminished CD25 expression in both CD4+CD25- T cells and CD4+CD25+ Treg cells. PGE2 exposure induced the Treg cell specific transcription factor FOXP3 in CD4+CD25- T cells and significantly upregulated its expression in CD4+CD25+ Treg cells. Supernatants from COX-2 overexpressing lung cancer cells that secrete high level PGE2 significantly induced FOXP3 in CD4+CD25- T cells. PGE2 upregulated FOXP3 at both mRNA and protein levels and enhanced FOXP3 promoter activity in Jurkat T cells. Based on these results in human Treg cells, we determined the role of tumor COX-2 expression on the frequency and activity of CD4+CD25+ Treg cells in murine lung cancer models in vivo. Tumor-derived COX-2/PGE2 induced expression of Foxp3 and increased Treg cell suppressive activities in vivo. Utilization of lymphocytes from EP2 and EP4 receptor knockout mice showed that the PGE2 mediated increase in Foxp3 gene expression in Treg cells was EP2 receptor dependent. In vivo, COX-2 inhibition reduced Treg cell frequency and activity, attenuated Foxp3 expression in tumor infiltrating lymphocytes and decreased tumor burden. Transfer of Treg cells or administration of PGE2 to mice receiving COX-2 inhibitors reversed these effects. We conclude that inhibition of COX-2/PGE2 suppresses Treg cell activity and enhances antitumor responses. This is the first report indicating that tumor-derived PGE2 can modulate FOXP3 expression and Treg function. These findings strengthen the rationale for the evaluation of COX-2 inhibition in lung cancer prevention and therapy.
Improving Drug Discovery by Nucleic Acid Delivery in Engineered Human Microlivers
Authors: Liliana Mancio-Silva, Heather E. Fleming, Alex B. Miller, Stuart Milstein, Abigail Liebow, Patrick Haslett, Laura Sepp-Lorenzino, Sangeeta N. Bhatia
Journal: Cell Metabolism (2019)

The liver plays a central role in metabolism; however, xenobiotic metabolism variations between human hepatocytes and those in model organisms create challenges in establishing functional test beds to detect the potential drug toxicity and efficacy of candidate small molecules. In the emerging areas of RNA interference, viral gene therapy, and genome editing, more robust, long-lasting, and predictive human liver models may accelerate progress. Here, we apply a new modality to a previously established, functionally stable, multi-well bioengineered microliver—fabricated from primary human hepatocytes and supportive stromal cells—in order to advance both small molecule and nucleic acid therapeutic pipelines. Specifically, we achieve robust and durable gene silencing in vitro to tune the human metabolism of small molecules, and demonstrate its capacity to query the potential efficacy and/or toxicity of candidate therapeutics. Additionally, we apply this engineered platform to test siRNAs designed to target hepatocytes and impact human liver genetic and infectious diseases.
Endoplasmic Reticulum Stress Signaling Comprises a G9a Inhibitor Tolerance Pathway and PERK Inhibition Increases Anti-Leukemia Activity of G9a Inhibitor in Leukemia Cells and Leukemia Stem-like Cells
Authors: Jieun Jang, Ju-In Eom, Hoi-kyung Jeung, So-Young Seol, Haerim Chung, Yu Ri Kim, June-Won Cheong, Yoo Hong Min
Journal: Blood (2018)
TEMPORAL CHANGES IN FFR-CT GUIDED MANAGEMENT OF CORONARY ARTERY DISEASE: LESSONS FROM THE ADVANCE REGISTRY
Authors: Koen Nieman, Fay Nous, Tim Fairbairn, Takashi Akasaka, Bjarne Norgaard, Daniel Berman, Gilbert Raff, Lynne Koweek, Gianluca Pontone, Tomohiro Kawasaki, Niels Peter Sand, Jesper Jensen, Tetsuya Amano, Michael Poon, Ovrehus Kristian, Jeroen Sonck, Ricardo Budde, Mark Rabbat, Bernard De Bruyne, Campbell Rogers, Whitney Huey, Hitoshi Matsuo, Jeroen J. Bax, Jonathon Leipsic, Manesh Patel
Journal: Journal of the American College of Cardiology (2019)
INFECTIVE ENDOCARDITIS IN PATIENTS WITH BICUSPID AORTIC VALVE: CLINICAL CHARACTERISTICS, COMPLICATIONS, AND PROGNOSIS OF A MULTI-CENTER INTERNATIONAL OBSERVATIONAL STUDY
Authors: William K.F. Kong, Elise Vollema, Francesca Prevedello, Arnold Ng, Rebecca Perry, Kian Keong Poh, Tiong Cheng Yeo, Miriam Shanks, Bogdan Popescu, Marcin Fijalkowski, Michael Liang, Wei Xian Chen, Nina Marsan, Joseph Selvanayagam, Fausto Pinto, Philippe Pibarot, Arturo Evangelista-Masip, Victoria Delgado, Jeroen J. Bax
Journal: Journal of the American College of Cardiology (2019)
GALECTIN 3: ‘UPSTREAM’ BIOMARKER OF MYOCARDIAL DYSFUNCTION WITH AGEING
Authors: Angela Su-Mei Koh, Bryan Keng, Fei Gao, See Hooi Ewe, Ru San Tan, Louis Teo, Bei Qi Xie, Woon-Puay Koh
Journal: Journal of the American College of Cardiology (2019)
PATIENTS WITH CARDIAC TAMPONADE ADMITTED DURING WEEKEND HOURS HAVE WORSE IN-HOSPITAL OUTCOMES: A REPORT FROM THE NATIONAL IN-PATIENT SAMPLE OF 2016
Authors: Faris Haddadin, Dhrubajyoti Bandyopadhyay, Hassan Beydoun, Alba Munoz Estrella, Vivek Modi, Jacqueline Tamis-Holland
Journal: Journal of the American College of Cardiology (2019)
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples
Authors: Richard Border, Emma C. Johnson, Luke M. Evans, Andrew Smolen, Noah Berley, Patrick F. Sullivan, Matthew C. Keller
Journal: American Journal of Psychiatry (2019)

Objective: Interest in candidate gene and candidate gene-by-environment interaction hypotheses regarding major depressive disorder remains strong despite controversy surrounding the validity of previous findings. In response to this controversy, the present investigation empirically identified 18 candidate genes for depression that have been studied 10 or more times and examined evidence for their relevance to depression phenotypes. Methods: Utilizing data from large population-based and case-control samples (Ns ranging from 62,138 to 443,264 across subsamples), the authors conducted a series of preregistered analyses examining candidate gene polymorphism main effects, polymorphism-by-environment interactions, and gene-level effects across a number of operational definitions of depression (e.g., lifetime diagnosis, current severity, episode recurrence) and environmental moderators (e.g., sexual or physical abuse during childhood, socioeconomic adversity). Results: No clear evidence was found for any candidate gene polymorphism associations with depression phenotypes or any polymorphism-by-environment moderator effects. As a set, depression candidate genes were no more associated with depression phenotypes than noncandidate genes. The authors demonstrate that phenotypic measurement error is unlikely to account for these null findings. Conclusions: The study results do not support previous depression candidate gene findings, in which large genetic effects are frequently reported in samples orders of magnitude smaller than those examined here. Instead, the results suggest that early hypotheses about depression candidate genes were incorrect and that the large number of associations reported in the depression candidate gene literature are likely to be false positives.
MSF suspends Congo Ebola effort after deadly clinic attacks
Authors: Owen Dyer
Journal: BMJ (2019)

The charity Medecins Sans Frontieres (MSF) will suspend operations in two towns at the epicentre of the Ebola outbreak in the Democratic Republic of the Congo, after unidentified groups launched two violent attacks on its clinics in the same week.

A mob appeared outside a clinic in Katwa on the night of 24 February, threw stones, and set fires. Patients and their caregivers were attacked while trying to flee, and a patient’s brother was killed.

“This attack has crippled our ability to respond to what is now the epicentre of the outbreak,” said Emmanuel Massart, MSF’s emergency coordinator in Katwa, after surveying the …
Patterns of Utilization and Outcome of Hematopoietic Stem Cell Transplantation Among Various Cancers: A Nationwide Analysis
Authors: Prabhjot Singh Bedi, Manoj P Rai, Justin D. Kaner, Samanjit Kaur Kandola, Varunsiri Atti, Shiva Shrotriya, Ikponmwosa Enofe, Nishant Tageja, Marwan S Abougergi, Heather Laird-Fick, James B. Bussel, Stanley M. Marks
Journal: Blood (2018)
Acquired BRAF Rearrangements Induce Secondary Resistance to EGFR therapy in EGFR-Mutated Lung Cancers
Authors: Morana Vojnic, Daisuke Kubota, Christopher Kurzatkowski, Michael Offin, Ken Suzawa, Ryma Benayed, Adam J. Schoenfeld, Andrew J. Plodkowski, John T. Poirier, Charles M. Rudin, Mark G. Kris, Neal X. Rosen, Helena A. Yu, Gregory J. Riely, Maria E. Arcila, Romel Somwar, Marc Ladanyi
Journal: Journal of Thoracic Oncology (2019)
The Immune Subtypes and Landscape of Squamous Cell Carcinoma
Authors: Bailiang Li, Yi Cui, Dhanya K. Nambiar, John B. Sunwoo, Ruijiang Li
Journal: Clinical Cancer Research (2019)

Abstract Purpose: To identify immune subtypes and investigate the immune landscape of squamous cell carcinomas (SCC), which share common etiology and histologic features. Experimental Design: Based on the immune gene expression profiles of 1,368 patients with SCC in the Cancer Genome Atlas (TCGA), we used consensus clustering to identify robust clusters of patients and assessed their reproducibility in an independent pan-SCC cohort of 938 patients. We further applied graph structure learning-based dimensionality reduction to the immune profiles to visualize the distribution of individual patients. Results: We identified and independently validated six reproducible immune subtypes associated with distinct molecular characteristics and clinical outcomes. An immune-cold subtype had the least amount of lymphocyte infiltration and a high level of aneuploidy, and these patients had the worst prognosis. By contrast, an immune-hot subtype demonstrated the highest infiltration of CD8+ T cells, activated NK cells, and elevated IFNγ response. Accordingly, these patients had the best prognosis. A third subtype was dominated by M2-polarized macrophages with potent immune-suppressive factors such as TGFβ signaling and reactive stroma, and these patients had relatively inferior prognosis. Other subtypes showed more diverse immunologic features with intermediate prognoses. Finally, our analysis revealed a complex immune landscape consisting of both discrete clusters and continuous spectrum. Conclusions: This study provides a conceptual framework to understand the tumor immune microenvironment of SCCs. Future work is needed to evaluate its relevance in the design of combination treatment strategies and guiding optimal selection of patients for immunotherapy.
REASONS FOR INAPPROPRIATE EMERGENCY DEPARTMENT ATTENDANCES IN PATIENTS WITH A HISTORY OF ATRIAL FIBRILLATION: RESULTS FROM THE MULTICENTRE AF-ED TRIAL
Authors: Ben Glover, Kathryn L. Hong, David Bakker, Jason Baley, Corinne Babiolakis, Chao Xue, Filipa Saramago, Damian Redfearn
Journal: Journal of the American College of Cardiology (2019)
Comparison of Rivaroxaban with Argatroban in Heparin Induced Thrombocytopenia Using Historical Controls : A Case-Control Study
Authors: Vivek Suresh Modi, Karan Jatwani, Sridevi Rajeeve, Gaurav Kakked, Hardikumar Patel, Dhrubajyoti Bandyopadhyay, Siva Krishna Mannem
Journal: Blood (2018)
Hard Times and Hard Stops
Authors: Anne Lucy Lifflander
Journal: JAMA (2019)

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Pharmacokinetic (PK) and Pharmacodynamic (PD) Studies of RUC-4 Succinate, a Novel αIIbβ3 Pure Antagonist for First Point of Contact Treatment of ST Segment Elevated Myocardial Infarction (STEMI)
Authors: Spandana Vootukuri, Jihong Li, Mark Nedelman, Mariana Babayeva, Barry S. Coller
Journal: Blood (2018)
QUANTITATION OF MITRAL VALVE STRAIN IN NORMALS AND IN PATIENTS WITH MITRAL VALVE PROLAPSE
Authors: Kinan Carlos El Tallawi, Peng Zhang, Robert Azencott, Jiwen He, Elizabeth Herrera, Mohammed Chamsi-Pasha, Jessen Jacob, Gerald M. Lawrie, William Zoghbi
Journal: Journal of the American College of Cardiology (2019)
IMPACT OF CARDIAC CONDITION ON PROGNOSIS IN PATIENTS WITH CRITICAL LIMB ISCHEMIA AFTER REVASCULARIZATION
Authors: Taku Toyoshima, Osamu Iida, Mitsutoshi Asai, Masaharu Masuda, Shin Okamoto, Takayuki Ishihara, Kiyonori Nanto, Takashi Kanda, Takuya Tsujimura, Shota Okuno, Yasuhiro Matsuda, Hiroyuki Kawai, Aki Tsuji, Yosuke Hata, Hiroyuki Uematsu, Yuki Sato, Naoko Higashino, Toshiaki Mano
Journal: Journal of the American College of Cardiology (2019)