tbuckley/cabot-search huggingface dataset:
Neoadjuvant FOLFIRINOX in Patients With Borderline Resectable Pancreatic Cancer: A Systematic Review and Patient-Level Meta-Analysis
Authors: Quisette P Janssen, Stefan Buettner, Mustafa Suker, Berend R Beumer, Pietro Addeo, Philippe Bachellier, Nathan Bahary, Tanios Bekaii-Saab, Maria A Bali, Marc G Besselink, Brian A Boone, Ian Chau, Stephen Clarke, Mary Dillhoff, Bassel F El-Rayes, Jessica M Frakes, Derek Grose, Peter J Hosein, Nigel B Jamieson, Ammar A Javed, Khurum Khan, Kyu-Pyo Kim, Song Cheol Kim, Sunhee S Kim, Andrew H Ko, Jill Lacy, Georgios A Margonis, Martin D McCarter, Colin J McKay, Eric A Mellon, Sing Yu Moorcraft, Ken-Ichi Okada, Alessandro Paniccia, Parag J Parikh, Niek A Peters, Hans Rabl, Jaswinder Samra, Christoph Tinchon, Geertjan van Tienhoven, Eran van Veldhuisen, Andrea Wang-Gillam, Matthew J Weiss, Johanna W Wilmink, Hiroki Yamaue, Marjolein Y V Homs, Casper H J van Eijck, Matthew H G Katz, Bas Groot Koerkamp
Journal: JNCI Journal of the National Cancer Institute (2019)

Abstract Background FOLFIRINOX is a standard treatment for metastatic pancreatic cancer patients. The effectiveness of neoadjuvant FOLFIRINOX in patients with borderline resectable pancreatic cancer (BRPC) remains debated. Methods We performed a systematic review and patient-level meta-analysis on neoadjuvant FOLFIRINOX in patients with BRPC. Studies with BRPC patients who received FOLFIRINOX as first-line neoadjuvant treatment were included. The primary endpoint was overall survival (OS), and secondary endpoints were progression-free survival, resection rate, R0 resection rate, and grade III–IV adverse events. Patient-level survival outcomes were obtained from authors of the included studies and analyzed using the Kaplan-Meier method. Results We included 24 studies (8 prospective, 16 retrospective), comprising 313 (38.1%) BRPC patients treated with FOLFIRINOX. Most studies (n = 20) presented intention-to-treat results. The median number of administered neoadjuvant FOLFIRINOX cycles ranged from 4 to 9. The resection rate was 67.8% (95% confidence interval [CI] = 60.1% to 74.6%), and the R0-resection rate was 83.9% (95% CI = 76.8% to 89.1%). The median OS varied from 11.0 to 34.2 months across studies. Patient-level survival data were obtained for 20 studies representing 283 BRPC patients. The patient-level median OS was 22.2 months (95% CI = 18.8 to 25.6 months), and patient-level median progression-free survival was 18.0 months (95% CI = 14.5 to 21.5 months). Pooled event rates for grade III–IV adverse events were highest for neutropenia (17.5 per 100 patients, 95% CI = 10.3% to 28.3%), diarrhea (11.1 per 100 patients, 95% CI = 8.6 to 14.3), and fatigue (10.8 per 100 patients, 95% CI = 8.1 to 14.2). No deaths were attributed to FOLFIRINOX. Conclusions This patient-level meta-analysis of BRPC patients treated with neoadjuvant FOLFIRINOX showed a favorable median OS, resection rate, and R0-resection rate. These results need to be assessed in a randomized trial.
Koebnerisin (S100A15): A novel player in the pathogenesis of rosacea
Authors: Aleksandra Batycka-Baran, Eva Hattinger, Aleksander Marchenkov, Maria Koziol, Andrzej Bieniek, Jacek Szepietowski, Thomas Ruzicka, Ronald Wolf
Journal: Journal of the American Academy of Dermatology (2019)
Activity of EGFR Tyrosine Kinase Inhibitors in NSCLC With Refractory Leptomeningeal Metastases
Authors: Ronan Flippot, Pamela Biondani, Edouard Auclin, Dingyu Xiao, Lizza Hendriks, Emilie Le Rhun, Charlotte Leduc, Michèle Beau-Faller, Radj Gervais, Jordi Remon, Julien Adam, David Planchard, Pernelle Lavaud, Charles Naltet, Caroline Caramella, Cécile Le Pechoux, Ludovic Lacroix, Anas Gazzah, Laura Mezquita, Benjamin Besse
Journal: Journal of Thoracic Oncology (2019)
ESOPHAGEAL RETENTION OF RESIDUE FROM N-ACETYLCYSTEINE CAPSULE IN PATIENTS UNDERGOING UPPER GASTROINTESTINAL ENDOSCOPY
Authors: JM Park, SH Lee, SJ Lee, SC Park, CD Kang, SJ Nam
Journal: Endoscopy (2019)

N-acetylcysteine (NAC) is a mucolytic agent, and NAC solution has been used to improve visibility during upper gastrointestinal (UGI) endoscopy. On the other hand, NAC capsule may leave a residue in the esophagus and interfere clear mucosal visualization. This study aimed to assess the frequency of esophageal retention of residue from NAC capsule during UGI endoscopy.
RISK OF ADVANCED LESIONS IN PATIENTS WITH BRANCH-DUCT IPMN AND RELATIVE INDICATIONS FOR SURGERY ACCORDING TO EUROPEAN EVIDENCE-BASED GUIDELINES
Authors: E Pérez-Cuadrado-Robles, L Uribarri-González, B Ivan, JJ Vila, S López-López, PH Deprez
Journal: Endoscopy (2019)

Recently, European evidence-based guidelines proposed surgery for branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs) based on the presence of 1 – 2 relative indications, depending on the comorbidity burden. However, most of studies to date considered patients with absolute and relative indications together and radiological examinations in the baseline evaluation.
Abstract P340: Structural Social Support and Cardiovascular Disease Risk Factors in Hispanic/Latino Adults With Diabetes: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Authors: Rosalba Hernandez, Mercedes Carnethon, Aida L Giachello, Frank J Penedo, Donghong Wu, Orit Birnbaum-Weitzman, Rebeca Espinoza Giacinto, Linda C Gallo, Carmen R Isasi, Neil Schneiderman, Yanping Teng, Donglin Zeng, Martha L Daviglus
Journal: Circulation (2017)

Introduction: There is mounting evidence linking social support to restorative health processes and favorable cardiovascular risk profiles. However, observational studies have yielded inconsistent findings on the associations of social support networks with cardiovascular health in Hispanic/Latino adults with diabetes. We examined the cross-sectional associations of structural social support and traditional cardiovascular disease ( CVD ) risk factors in a diverse sample of Hispanic/Latino adults with diabetes. Hypothesis: Persons with lower indices of social support will have higher odds of adverse CVD risk factors. Methods: This analysis included 2,994 adult participants ages 18-74 with diabetes from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL—2008-2011). Select items from the Social Network Inventory were used to assess indices of structural social support, i.e., network size (number of children, parents, and in-laws) and frequency of familial contact. Standardized methods were used to measure diabetes and other CVD risk factors -- abdominal obesity, body mass index, hypertension, hypercholesterolemia, and smoking status. Multivariate regression was used to examine associations of structural support with individual CVD risk factors with demographics, acculturation, physical health, and psychological distress included as covariates. Results: There were no significant cross-sectional associations of structural support indices with abdominal obesity, hypertension, hypercholesterolemia, or smoking status. There was a marginally significant (OR: 1.05; 95% CI 1.00-1.12) trend toward higher odds of obesity in participants reporting a larger family unit (including children, parents, and in-laws) ( Table 1 ). Conclusions: Structural social support was marginally associated with higher odds of obesity in Hispanic/Latino adults with diabetes. Alternate forms of social support should be further explored as potential markers of cardiac risk in Hispanics/Latinos with diabetes.
Reply
Authors: Rosalie C. Oey, Manon C. W. Spaander, Henk R. van Buuren, Robert A. de Man
Journal: Hepatology (2019)

Potential conflict of interest: Nothing to report. We thank our colleagues for their interest in our study. Although the risk for colorectal carcinoma after liver transplantation may be increased, our study shows that in this particular, vulnerable population the yield of advanced neoplasia detected by colonoscopy is low and is associated with an elevated risk of complications. In addition, we would like to stress the fact that only just over 50% of the screened patients actually underwent liver transplantation. Based on these data, the timing of performing a screening colonoscopy may be reconsidered, e.g., performing screening colonoscopies post–liver transplantation in a subset of patients. Although the sensitivity of the fecal immunochemical test (FIT) is low for adenoma and serrated lesions, sensitivity for colorectal carcinoma is around 80%. Therefore, FIT may be used as an alternative to screen patients pre–liver transplantation. We agree that if FIT is chosen, the cutoff used will be essential to assure an optimal benefit–risk balance. We continue to believe that the benefit–harm ratio of screening colonoscopy in all potential candidate patients for liver transplantation is questionable and that other strategies should be considered and further explored.
ENDOCLEAN: AUTOMATIC EVALUATION OF THE CLEANLINESS OF THE SMALL BOWEL IN CAPSULE ENDOSCOPY PROCEDURES
Authors: A Nevárez, R Noorda, V Naranjo, N Alonso, V Pons
Journal: Endoscopy (2019)

Poor visualization of the small bowel due to the presence of intestinal content remains one of the main limitations in capsule endoscopy (CE) procedures. The aim of our study was to develop a tool that can automatically detect intestinal content in CE procedures.
Beyond silicosis, is the world failing on silica hazards?
Authors: Catherine Cavalin, Alain Lescoat, Alice Ballerie, Nicolas Belhomme, Patrick Jégo, Stéphane Jouneau, Valérie Lecureur, Mathieu Lederlin, Christophe Paris, Paul-André Rosental
Journal: The Lancet Respiratory Medicine (2019)
Abstract 664: Disruption of the BMP Type II Receptor Alters the Dynamics of BMP Pathway Activation, Abrogating BMP-mediated Growth Inhibition and Differentiation in Pulmonary Artery Smooth Muscle Cells
Authors: Paul B Yu, Donna Y Deng, Hideyuki Beppu, Stefan A Hoyng, Noriko Kawai, Kenneth D Bloch
Journal: Circulation (2007)

Bone morphogenetic protein (BMP) signals regulate growth and differentiation of vascular cells and may contribute to vascular calcific disease. The association of BMP type II receptor (BMPRII) gene...
TRADITIONAL SERRATED ADENOMA – SIGNS OF SERRATED AND NONSERRATED TYPES OF COLON POLYPS
Authors: N Ageykina, N Oleynikova, P Malkov, E Fedorov, N Danilova, O Kharlova
Journal: Endoscopy (2019)

To study the endoscopic and pathological features of traditional serrated adenoma (TSAs) of the colon.
EUS-GUIDED BILIARY DRAINAGE AFTER ERCP FAILURE IN ONCOLOGY PATIENTS
Authors: C Casamali, B Costa Martins, R Corsato Scomparim, LM Azeredo Coutinho, O Okazaki, G Andrade de Paulo, L Lenz, S Eiji Matuguma, M Coronel, M Cavalcante Franco, A Vaz Safatle-Ribeiro, CMP Pennacchi, F Maluf-Filho
Journal: Endoscopy (2019)

Evaluate the technical and clinical success, survival, patency time of the stents and complications related to the procedure.
INCIDENCE AND RISK FACTORS FOR SESSILE SERRATED ADENOMAS AFTER CURATIVE SURGERY IN LEFT-SIDE COLON CANCER PATIENTS
Authors: HS Moon, MH Kim, JH Park, JS Kim, SH Kang, JK Sung, HY Jeong
Journal: Endoscopy (2019)

Sessile serrated adenomas (SSAs) are known to be precursors of colorectal cancer (CRC). However, data regarding detection rates of premalignant lesions during colonoscopy surveillance in patients with a history of left-sided colonic resection for cancer are lacking. In this study, we aimed to identify the incidence and risk factors for serrated adenoma in left-side colorectal cancer patients.
18F-FDG PET/CT Imaging of Trichoblastic Carcinoma With Nodal Metastasis
Authors: Ba Duong Nguyen, Mahesh Seetharam, Tolgay I. Ocal
Journal: Clinical Nuclear Medicine (2019)

Trichoblastic carcinoma is an uncommon malignant neoplasm arising from follicular germinative cells. The high-grade trichoblastic carcinoma has been reported with lymphatic and hematogenous dissemination. The authors present a 59-year-old man with gluteal cleft trichoblastic carcinoma and highlight the useful role of serial F-FDG PET/CT examinations in the demonstration of initial and subsequent nodal metastasis in the inguina and pelvis.
Nivolumab alone or in combination with cisplatin plus gemcitabine in Japanese patients with unresectable or recurrent biliary tract cancer: a non-randomised, multicentre, open-label, phase 1 study
Authors: Makoto Ueno, Masafumi Ikeda, Chigusa Morizane, Satoshi Kobayashi, Izumi Ohno, Shunsuke Kondo, Naohiro Okano, Keisuke Kimura, Suguru Asada, Yoshinobu Namba, Takuji Okusaka, Junji Furuse
Journal: The Lancet. Gastroenterology & hepatology (2019)
Therapy resistance mediated by exosomes
Authors: Teresa Bernadette Steinbichler, József Dudás, Sergej Skvortsov, Ute Ganswindt, Herbert Riechelmann, Ira-Ida Skvortsova
Journal: Molecular Cancer (2019)

Therapy resistance can arise within tumor cells because of genetic or phenotypic changes (intrinsic resistance), or it can be the result of an interaction with the tumor microenvironment (extrinsic resistance). Exosomes are membranous vesicles 40 to 100 nm in diameter constitutively released by almost all cell types, and mediate cell-to-cell communication by transferring mRNAs, miRNAs, DNAs and proteins causing extrinsic therapy resistance. They transfer therapy resistance by anti-apoptotic signalling, increased DNA-repair or delivering ABC transporters to drug sensitive cells. As functional mediators of tumor-stroma interaction and of epithelial to mesenchymal transition, exosomes also promote environment-mediated therapy resistance. Exosomes may be used in anticancer therapy exploiting their delivery function. They may effectively transfer anticancer drugs or RNAs in the context of gene therapy reducing immune stimulatory effects of these drugs and hydrophilic qualities facilitating crossing of cell membranes.
Abstract 14854: Optimal Cut-off Points of Waist Circumference for Detecting Central Obesity and Severe Central Obesity in Chinese Adults
Authors: Xiaoxiao Wen, Jinzhuang Mai, Xiangmin Gao, Min Guo, Yong Wu, Xiaoqing Liu, Liancheng Zhao
Journal: Circulation (2015)

Introduction: Given that no consensus has yet been reached over the optimal cut-off points of waist circumference (WC) for Chinese, this study aimed to determine the appropriate cut-off points of WC for detecting central obesity and severe central obesity in a Chinese adult population. Methods: Data from the cross-sectional survey of the PRC-USA Collaborative study of Cardiovascular and Cardiopulmonary Epidemiology in 1993-1994 was used, including 10265 subjects (4921 men and 5344 women) aged 35-69 years. Each integer of WC in centimeters was used as the cut-off point to detect clustering of cardiovascular risk factors, which was defined as the presence of two or more risk factors among hypertension, diabetes, hypercholesterolemia, hypertriglyceridemia and low levels of high-density lipoprotein cholesterol. Based on the Receiver operating characteristic (ROC) curve analysis, the WC value corresponding to the point on the ROC curve nearest to the upper left corner of the ROC graph was considered the optimal cut-off for central obesity and the value corresponding to the point with specificity of 90% or more was considered the optimal cut-off for severe central obesity. Results: The optimal cut-off value of WC to detect clustering of risk factors was ≥84 cm for men and was ≥80 cm for women with the shortest distance to the upper left corner being 0.4304 and 0.4504, respectively. The cut-off values of WC with specificity above 90% were ≥93 cm and ≥91 cm for men and women respectively. Conclusions: These results were equal or similar to the WC cut-off points proposed by the Guidelines for Prevention and Control of Overweight and Obesity in Chinese Adults, i.e., ≥85/80 cm (men/women) for increased risk for obesity related diseases and ≥95/90 cm (men/women) for much higher risk. For practical reasons, WC≥85/80 cm and ≥95/90 cm (men/women) could be the optimal cut-off values for detecting central obesity and severe central obesity, respectively, in Chinese adult population.
FACTORS ASSOCIATED WITH DIFFICULTY IN PROPHYLACTIC CLIP CLOSURE AFTER ENDOSCOPIC MUCOSAL RESECTION OF LARGE COLORECTAL POLYPS
Authors: O Ortiz, M Pellise, DK Rex, IS Grimm, MT Moyer, MK Hasan, D Pleskow, BJ Elmunzer, MA Kashab, O Sanaei, FH Al-Kawas, S Gordon, A Mathew, JM Levenick, HR Aslanian, F Antaki, D Von Renteln, SD Crockett, A Rastogi, JA Gill, RJ Law, P Elias, TA Mackenzie, H Pohl
Journal: Endoscopy (2019)

Evaluate factors associated with inability to achieve prophylactic complete clip closure of the mucosal defect after endoscopic mucosal resection (EMR) of large ≥20 mm non-pedunculated colorectal polyps.
GLASGOW-BLACHFORD SCORE ACCURATELY PREDICTS THE NEED OF CLINICAL INTERVENTION IN ACUTE LOWER GASTROINTESTINAL BLEEDING. A DIAGNOSTIC ACCURACY EVALUATION STUDY
Authors: A Lira, S Machlab, P Garcia-Iglesias, E Martinez-Bauer, C Mármol, G Llibre, J Da Costa, M Gallach, L Melcarne, V Puig-Diví, F Junquera, R Campo, X Calvet, E Brullet
Journal: Endoscopy (2019)

The aim of this study was to compare the accuracy of Glasgow-Blachford score (GBS) with thre risk scores (State, Velayos and Newman) for predicting the need of clinical intervention (endoscopic therapy, vascular embolization and surgery or transfusion) in patients admitted for acute LGB.
Chronic hepatitis delta virus infection leads to functional impairment and severe loss of MAIT cells
Authors: Joana Dias, Julia Hengst, Tiphaine Parrot, Edwin Leeansyah, Sebastian Lunemann, David F.G. Malone, Svenja Hardtke, Otto Strauss, Christine L. Zimmer, Lena Berglin, Thomas Schirdewahn, Sandra Ciesek, Nicole Marquardt, Thomas von Hahn, Michael P. Manns, Markus Cornberg, Hans-Gustaf Ljunggren, Heiner Wedemeyer, Johan K. Sandberg, Niklas K. Björkström
Journal: Journal of Hepatology (2019)
Harry Myers Alty
Authors: Adrian Flower, John Cawood
Journal: BMJ (2019)

Henry Myers Alty—known as “Harry,” or, to be precise, “HMA” to his many colleagues—was modest and above all unflappable, which are the traits that spring to mind when remembering this caring gentleman. He was a man of immense ability, secure within himself and always in control. He resolved many a conflict with tact and diplomacy, keeping all sides satisfied.

Harry Alty was born in Newburgh, Lancashire, the eldest of three brothers. He was educated at Hutton Grammar School and then followed his father into the dental profession and obtained the BDS (University of Liverpool) in 1952. He started training in oral surgery at St Bartholomew’s and the Eastman Dental hospitals. He obtained the FDSRCS (Eng) in 1954 and qualified …
La papille para/intra diverticulaire est elle un facteur d'échec et de complications au cours de la cholangio pancréatografie rétrograde endoscopique?
Authors: M Yakoubi, M Medhioub, O Gharbi, L Hamzaoui, A Khsiba, M Mahmoudi, MM Azouz
Journal: Endoscopy (2019)

La papille duodénale para ou intra diverticulaire est retrouvée dans environ 10 à 20% des cholangiopancréatografies rétrogrades endoscopique (CPRE). Elle peut être source d'échec du cathétérisme de la voie biliaire principale (VBP) et de complications intercurrentes.
Integrating precision medicine through evaluation of cell of origin in treatment planning for diffuse large B-cell lymphoma
Authors: Grzegorz S. Nowakowski, Tatyana Feldman, Lisa M. Rimsza, Jason R. Westin, Thomas E. Witzig, Pier Luigi Zinzani
Journal: Blood Cancer Journal (2019)

Precision medicine is modernizing strategies for clinical study design to help improve diagnoses guiding individualized treatment based on genetic or phenotypic characteristics that discriminate between patients with similar clinical presentations. Methodology to personalize treatment choices is being increasingly employed in clinical trials, yielding favorable correlations with improved response rates and survival. In patients with diffuse large B-cell lymphoma (DLBCL), disease characteristics and outcomes may vary widely, underscoring the importance of patient classification through identification of sensitive prognostic features. The discovery of distinct DLBCL molecular subtypes based on cell of origin (COO) is redefining the prognosis and treatment of this heterogeneous cancer. Owing to significant molecular and clinical differences between activated B-cell-like (ABC)- and germinal center B-cell-like (GCB)-DLBCL subtypes, COO identification offers opportunities to optimize treatment selection. Widespread adoption of COO classification would greatly improve treatment and prognosis; however, limitations in interlaboratory concordance between immunohistochemistry techniques, cost, and availability of gene expression profiling tools undermine universal integration in the clinical setting. With advanced methodology to determine COO in a real-world clinical setting, therapies targeted to specific subtypes are under development. The focus here is to review applications of precision medicine exemplified by COO determination in DLBCL patients.
What should I eat on my night shift?
Authors: Abi Rimmer
Journal: BMJ (2019)

The effect of a disrupted sleep cycle on energy metabolism is real but of modest size.In the end, it's about the practicalities of food access, convenience, and the time demands of the shift.Planning ahead is your friend.Your first thought should be hydration-go for water and other calorie free drinks because you will need a lot of it.Dehydration, paradoxically often from too much caffeine, is a common cause of fatigue."Before your shift, eat a main meal with whole grains and other complex starches to curb your hunger and cravings."Take your own food with you so that you don't fall into the delivery service and vending machine trap.Convenience foods typically contain extra calories, sugar, saturated fat, and salt, but do not keep you full for long.Sugary and salty foods are also a major reason for the weight gain that is such a common problem for shift workers."Plan for your meal breaks: high protein foods like chicken and hummus are filling and calm cravings, while prepackaged healthy snacks, such as unsalted nuts and cut vegetables, are accessible on the run.Always pack water with your lunch box."
FEASIBILITY AND SAFETY OF ENDOSCOPIC SUBMUCOSAL DISSECTION FOR SUPERFICIAL NEOPLASMS IN PATIENTS WITH ULCERATIVE COLITIS
Authors: T Maehata, K Fukuhara, K Tsutsumi, Y Kiguchi, T Akimoto, A Nakayama, Y Ochiai, M Kato, Y Iwao, N Yahagi
Journal: Endoscopy (2019)

In patients with ulcerative colitis (UC), sporadic neoplasms (SN) can also occur in addition to UC-associated colorectal cancer/dysplasia (UCAC). Recently, reports on endoscopic submucosal dissection (ESD) for UCAC and SN have been published. However, there is no consensus regarding ESD. We retrospectively evaluated the feasibility and safety of ESD for UCAC and SN.
Endoscopic ultrasound-guided gastrojejunostomy using fully covered metal stent combined with large-loop double-pigtail stent for malignant afferent loop syndrome
Authors: Hideyuki Shiomi, Takashi Kobayashi, Arata Sakai, Yuuki Shiomi, Atsuhiro Masuda, Edgardo M. Bondoc, Yuzo Kodama
Journal: Endoscopy (2019)

Afferent loop syndrome (ALS) is a known adverse event following Whipple procedure. A palliative surgical bypass is invasive and can only be performed in a limited selection of patients [1]. Recently, a minimally invasive approach, endoscopic ultrasound-guided gastrojejunostomy (EUS-GJ) using a lumen-apposing metal stent (LAMS), has been reported [2] [3] [4]. The LAMS has the advantages of preventing both stent migration and leakage of fluid. However, the LAMS is not available in many countries and is more expensive than the conventional fully covered self-expandable metal stent (FCSEMS). Therefore, we developed a method involving an FCSEMS with antimigration properties, comprising a large-loop double-pigtail plastic stent within an FCSEMS ([Fig. 1]). Herein, we describe technical tips for EUS-GJ using the modified stent system ([Video 1]).
Inactivation of PKHD1 results in a liver phenotype characteristic of autosomal recessive polycystic kidney disease (ARPKD)
Authors: Rachel Gallagher, Ernie Esquivel, Xin Tian, Tiffany Samaroo, Dhanpat Jain, Luiz Onuchie, Lisa Guay Woodford, Gregory Germino, Stefan Somlo
Journal: Journal of the American Society of Nephrology (2004)