tbuckley/cabot-search huggingface dataset:
Correction to: Surgery in reference centers improves survival of sarcoma patients: a nationwide study
Authors: J.-Y. Blay, C. Honoré, E. Stoeckle, P. Meeus, M. Jafari, F. Gouin, P. Anract, G. Ferron, A. Rochwerger, M. Ropars, S. Carrere, F. Marchal, F. Sirveaux, A. Di Marco, L.R. Le Nail, J. Guiramand, G. Vaz, J.-C. Machiavello, O. Marco, S. Causeret, P. Gimbergues, F. Fiorenza, L. Chaigneau, F. Guillemin, J.-M. Guilloit, F. Dujardin, J.-P. Spano, J.-C. Ruzic, A. Michot, P. Soibinet, E. Bompas, C. Chevreau, F. Duffaud, M. Rios, C. Perrin, N. Firmin, F. Bertucci, C. Le Pechoux, F. Le Loarer, O. Collard, M. Karanian-Philippe, M. Brahmi, A. Dufresne, A. Dupré, F. Ducimetière, A. Giraud, D. Pérol, M. Toulmonde, I. Ray-Coquard, A. Italiano, A. Le Cesne, N. Penel, S. Bonvalot
Journal: Annals of Oncology (2019)

Ann Oncol 2019; (doi: 10.1093/annonc/mdz124) In the original article, Figure 1F was identical to 1D. The Figure has now been corrected. Surgery in reference centers improves survival of sarcoma patients: a nationwide studyAnnals of OncologyVol. 30Issue 7PreviewNETSARC (netsarc.org) is a network of 26 sarcoma reference centers with specialized multidisciplinary tumor boards (MDTB) aiming to improve the outcome of sarcoma patients. Since 2010, presentation to an MDTB and expert pathological review are mandatory for sarcoma patients nationwide. In the present work, the impact of surgery in a reference center on the survival of sarcoma patients investigated using this national NETSARC registry. Full-Text PDF Open Access
Hepatitis B Core-Related Antigen to Indicate High Viral Load: Systematic Review and Meta-Analysis of 10,397 Individual Participants
Authors: Kyoko Yoshida, Alice Desbiolles, Sarah F. Feldman, Sang Hoon Ahn, Enagnon K. Alidjinou, Masanori Atsukawa, Laurence Bocket, Maurizia R. Brunetto, Maria Buti, Ivana Carey, Gian Paolo Caviglia, En-Qiang Chen, Markus Cornberg, Masaru Enomoto, Masao Honda, Christoph Höner Zu Siederdissen, Masatoshi Ishigami, Harry L.A. Janssen, Benjamin Maasoumy, Takeshi Matsui, Akihiro Matsumoto, Shuhei Nishiguchi, Mar Riveiro-Barciela, Akinobu Takaki, Pisit Tangkijvanich, Hidenori Toyoda, Margo J.H. van Campenhout, Bo Wang, Lai Wei, Hwai-I Yang, Yoshihiko Yano, Hiroshi Yatsuhashi, Man-Fung Yuen, Eiji Tanaka, Maud Lemoine, Yasuhito Tanaka, Yusuke Shimakawa
Journal: Clinical Gastroenterology and Hepatology (2020)
Molecular mechanisms of nickel carcinogenesis.
Authors: M Costa, K Salnikow, S Cosentino, C B Klein, X Huang, Z Zhuang
Journal: Environmental Health Perspectives (1994)

Carcinogenic, water-insoluble Ni compounds are phagocytized by cells; and the particles undergo dissolution inside the cell, releasing Ni ions that interact with chromatin. Ni produces highly selective damage to heterochromatin. The longest contiguous region of heterochromatin in the Chinese hamster genome is found on the q arm of the X chromosome, and this region is selectively damaged by Ni. More than half of the male mice in which there were Ni-induced transformations of Chinese hamster cells exhibited complete deletion of the long arm of the X chromosome. The introduction of a normal X chromosome into these cells resulted in cellular senescence, suggesting that the Ni interacted with Chinese hamster genome to inactivate a senescence gene. Investigations were conducted into the mechanisms by which Ni produced damage to chromatin. Ni ions have a much higher affinity for proteins and amino acids than for DNA (by five to seven orders of magnitude). Therefore, Ni interacted with chromatin because of the protein present, not because of its reactivity for DNA. Studies have shown that Ni produced an increase in oxidative products in cells as indicated by oxidation of the fluorescent dye dichlorofluorescein; Ni has also been shown to produce oxidation of proteins in cells, as measured by carbonyl formation. Ni cross-linked certain amino acids and proteins to DNA. These covalent cross-links were not dissociated by EDTA and are inconsistent with direct Ni involvement, but they are consistent with Ni acting catalytically. Using subtractive hybridization, we have isolated a number of clones that are expressed in normal but not in Ni-transformed cells.(ABSTRACT TRUNCATED AT 250 WORDS)
The Tumor-Suppressive Human Circular RNA CircITCH Sponges miR-330-5p to Ameliorate Doxorubicin-Induced Cardiotoxicity Through Upregulating SIRT6, Survivin, and SERCA2a
Authors: Dong Han, Yongjun Wang, Yabin Wang, Xinchun Dai, Tingwen Zhou, Jiangwei Chen, Bo Tao, Jibin Zhang, Feng Cao
Journal: Circulation Research (2020)

Rationale: Doxorubicin is one of the most potent antitumor agents available; however, its clinical use is restricted because it poses a risk of severe cardiotoxicity. Previous work has established that CircITCH (circular RNA ITCH [E3 ubiquitin-protein ligase]) is a broad-spectrum tumor-suppressive circular RNA and that its host gene, ITCH (E3 ubiquitin protein ligase), is involved in doxorubicin-induced cardiotoxicity (DOXIC). Whether CircITCH plays a role in DOXIC remains unknown. Objective: We aimed to dissect the role of CircITCH in DOXIC and further decipher its potential mechanisms. Methods and Results: Circular RNA sequencing was performed to screen the potentially involved circRNAs in DOXI pathogenesis. Quantitative polymerase chain reaction and RNA in situ hybridization revealed that CircITCH was downregulated in doxorubicin-treated human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) as well as in the autopsy specimens from cancer patients who suffered from doxorubicin-induced cardiomyopathy. Cell death/viability assays, detection of cardiomyocyte necrosis markers, microelectrode array, and cardiomyocyte functional assays revealed that CircITCH ameliorated doxorubicin-induced cardiomyocyte injury and dysfunction. Detection of cellular/mitochondrial oxidative stress and DNA damage markers verified that CircITCH alleviated cellular/mitochondrial oxidative stress and DNA damage induced by doxorubicin. RNA pull-down assays, Ago2 immunoprecipitation and double fluorescent in situ hybridization identified miR-330-5p as a direct target of CircITCH. Moreover, CircITCH was found to function by acting as an endogenous sponge that sequestered miR-330-5p. Bioinformatic analysis, luciferase reporter assays, and quantitative polymerase chain reaction showed that SIRT6 (sirtuin 6), BIRC5 (baculoviral IAP repeat containing 5, Survivin), and ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca 2+ transporting 2, SERCA2a [SR Ca 2+ -ATPase 2]) were direct targets of miR-330-5p and that they were regulated by the CircITCH/miR-330-5p axis in DOXIC. Further experiments demonstrated that CircITCH-mediated alleviation of DOXIC was dependent on the interactions between miR-330-5p and the 3′-UTRs of SIRT6, BIRC5, and ATP2A2 mRNA. Finally, AAV9 (adeno-associated virus serotype 9) vector-based overexpression of the well-conserved CircITCH partly prevented DOXIC in mice. Conclusions: CircITCH represents a novel therapeutic target for DOXIC because it acts as a natural sponge of miR-330-5p, thereby upregulating SIRT6, Survivin and SERCA2a to alleviate doxorubicin-induced cardiomyocyte injury and dysfunction.
Etiology of Autism Spectrum Disorders and Autistic Traits Over Time
Authors: Mark J. Taylor, Mina A. Rosenqvist, Henrik Larsson, Christopher Gillberg, Brian M. D’Onofrio, Paul Lichtenstein, Sebastian Lundström
Journal: JAMA Psychiatry (2020)

The frequency with which autism spectrum disorders (ASDs) are diagnosed has shown a marked increase in recent years. One suggestion is that this is partly because of secular changes in the environment, yet to our knowledge this hypothesis lacks evidence.To assess whether the relative importance of genetic and environmental associations with ASD and autistic traits has changed over a 16-year and 26-year period.A twin design was used to assess whether the heritability of ASD and autistic traits has changed over time. Data from 2 nationwide Swedish twin cohorts was used: the Swedish Twin Registry (STR; participants born between January 1982 and December 2008) and the Child and Adolescent Twin Study in Sweden (CATSS; participants born between January 1992 and December 2008). Autism spectrum disorder diagnoses were identified for twins in the STR, with follow-up to 2013. Questionnaires assigned screening diagnoses of ASD to CATSS participants and assessed autistic traits. Analyses were performed from September 1, 2018, to March 31, 2019.Each sample was divided into several birth cohorts covering 1982 to 1991 (for the STR only), 1992-1995, 1996-1999, 2000-2003, and 2004-2008.We assessed whether the genetric and environment variance underlying autistic traits changed across birth cohorts and examined whether the relative contribution of genetics and environment to liability for autism changed across birth cohorts.Data were available for 22 678 twin pairs (5922 female same-sex pairs [26.1%], 5563 male same-sex pairs [24.5%], and 11193 opposite-sex pairs [49.4%]) in the STR and 15 280 pairs (4880 female same-sex pairs [31.9%], 5092 male same-sex pairs [33.3%], and 5308 opposite-sex pairs [34.7%]) in CATSS. The heritability of ASD diagnoses in the STR ranged from 0.88 (95% CI, 0.74-0.96) to 0.97 (95% CI, 0.89-0.99). The heritability of screening diagnoses in CATSS varied from 0.75 (95% CI, 0.58-0.87) to 0.93 (95% CI, 0.84-0.98). Autistic traits showed a modest variance increase over time that was associated with increases in genetic and environmental variance, with the total variance increasing from 0.95 (95% CI, 0.92-0.98) to 1.17 (95% CI, 1.13-1.21) over time.Weak evidence was found for changes in the genetic and environmental factors underlying ASD and autistic traits over time. Genetic factors played a consistently larger role than environmental factors. Environmental factors are thus unlikely to explain the increase in the prevalence of ASD.
Radionuclide Therapy of Bone Metastases with Radium-223 Chloride in Prostate Cancer Patients
Authors: Holger Palmedo
Journal: Clinical Nuclear Medicine (2020)

Radium-223 chloride can prolong survival and improve quality of life in symptomatic, castration-resistant prostate cancer patients. It should be restricted to patients without visceral metastases (lymph node metastases excluded) having received two systemic second-line treatments. As a monotherapy before or after chemotherapy, radium-223 has a favourable safety profile.
Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36
Authors: Zachary T. McEachin, Tania F. Gendron, Nisha Raj, María García-Murias, Anwesha Banerjee, Ryan H. Purcell, Patricia J. Ward, Tiffany W. Todd, Megan E. Merritt-Garza, Karen Jansen-West, Chadwick M. Hales, Tania García-Sobrino, Beatriz Quintáns, Christopher J. Holler, Georgia Taylor, Beatriz San Millán, Susana Teijeira, Toru Yamashita, Ryuichi Ohkubo, Nicholas M. Boulis, Chongchong Xu, Zhexing Wen, Nathalie Streichenberger, Brent L. Fogel, Thomas Kukar, Koji Abe, Dennis W. Dickson, Manuel Arias, Jonathan D. Glass, Jie Jiang, Malú G. Tansey, María-Jesús Sobrido, Leonard Petrucelli, Wilfried Rossoll, Gary J. Bassell
Journal: Neuron (2020)
Optimising trial design in late-stage primary biliary cholangitis : evaluating options for composite clinical endpoint studies
Authors: Carla Fiorella Murillo Perez, Willem J Lammers, Annarosa Floreani, Christophe Corpechot, Adriaan Van der Meer, Aliya Gulamhusein, Cyriel Ponsioen, Marco Carbone, Marlyn J Mayo, Pietro Invernizzi, Pier Maria Battezzati, Keith D Lindor, Frederik Nevens, Kris Kowdley, Tony Bruns, Andrew L Mason, George N Dalekos, Nikolaos K Gatselis, Douglas Thorburn, Xavier Verhelst, Albert Pares, Palak Trivedi, Harry La Janssen, Gideon Hirschfield, Bettina E Hansen
Journal: Hepatology (2019)
The need for speed! 10 ways that WhatsApp and instant messaging can enhance communication (and clinical care) in sport and exercise medicine
Authors: Osman Hassan Ahmed, Sean Carmody, Lewis J Walker, Imtiaz Ahmad
Journal: British Journal of Sports Medicine (2020)

Just as the majority of athletes are constantly seeking to get faster and better, sport and exercise medicine (SEM) clinicians need quicker and more efficient strategies to communicate with their athletes and colleagues. This drive for enhanced communication by clinicians is underscored by Ekstrand and colleagues’ finding that positive internal communication between the medical team and the head coach/manager in elite football reduced injury burden and increased player availability.1 Return-to-play timings can make or break a team’s success in elite sport, and it is natural for clinical teams to push boundaries with regards to their speed of communication.

At the elite level of sport, the majority of SEM clinicians will use some form of instant messaging (IM platform) for three main purposes:

1.  To discuss player findings with other staff members.

2.  To plan treatment sessions.

3.  To interact with athletes to reassure/advise them on their status and recovery.

Table 1 outlines examples of these, …
Emicizumab Prophylaxis in Adolescent/Adult Patients with Hemophilia A Previously Receiving Episodic or Prophylactic Bypassing Agent Treatment: Updated Analyses from the HAVEN 1 Study
Authors: Maria Elisa Mancuso, Michael U. Callaghan, Rebecca Kruse-Jarres, Christine L Kempton, Jin Xu, Olivier Catalani, Elina Asikanius, Gallia G. Levy, Midori Shima, Guy Young, Johannes Oldenburg
Journal: Blood (2017)
Epidemiology of and Risk Factors for Coronavirus Infection in Health Care Workers
Authors: Roger Chou, Tracy Dana, David I. Buckley, Shelley Selph, Rongwei Fu, Annette M. Totten
Journal: Annals of Internal Medicine (2020)

Health care workers (HCWs) are at risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Impact of numerical variation, allele burden, mutation length and co-occurring mutations on the efficacy of tyrosine kinase inhibitors in newly diagnosed FLT3- mutant acute myeloid leukemia
Authors: Iman Abou Dalle, Ahmad Ghorab, Keyur Patel, Xuemei Wang, Hyunsoo Hwang, Jorge Cortes, Ghayas C. Issa, Fevzi Yalniz, Koji Sasaki, Dai Chihara, Allyson Price, Tapan Kadia, Naveen Pemmaraju, Naval Daver, Courtney DiNardo, Farhad Ravandi, Hagop M. Kantarjian, Gautam Borthakur
Journal: Blood Cancer Journal (2020)

Abstract FLT3 -ITD mutations in newly diagnosed acute myeloid leukemia (AML) are associated with worse overall survival (OS). FLT3 -ITD diversity can further influence clinical outcomes. Addition of FLT3 inhibitors to standard chemotherapy has improved OS. The aim of this study is to evaluate the prognostic impact of FLT3 diversity and identify predictors of efficacy of FLT3 inhibitors. We reviewed prospectively collected data from 395 patients with newly diagnosed FLT3 -ITD mutant AML. 156 (39%) patients received FLT3 inhibitors combined with either high or low intensity chemotherapy. There was no statistically significant difference in clinical outcomes among patients treated with FLT3 inhibitors based on FLT3 numerical variation ( p = 0.85), mutation length ( p = 0.67). Overall, the addition of FLT3 inhibitor to intensive chemotherapy was associated with an improved OS (HR = 0.35, 95% CI: 0.24–0.5, p = 0.0005), but not in combination with lower intensity chemotherapy (HR = 0.98, 95%CI: 0.7–1.36, p = 0.85). A differential effect of FLT3 inhibitor on OS was more pronounced in younger patients with FLT3 allelic ratio ≥0.5 (HR = 0.41, 95% CI: 0.25–0.66, p &lt; 0.001), single ITD mutation (HR = 0.55, 95% CI: 0.34–0.88, p = 0.01), diploid cytogenetics (HR = 0.52, 95% CI: 0.35–0.76, p = 0.001), NPM1 co-mutation (HR = 0.35, 95% CI: 0.19–0.67, p = 0.001). Our analysis identifies predictors of survival among diverse FLT3 related variables in patients treated with FLT3 inhibitor.
Colorectal cancer in young patients: Is it a distinct clinical entity?
Authors: Hadar Goldvaser, Ofer Purim, Yulia Kundel, Olga Ulitsky, Daniel Shepshelovich, Nir Wasserberg, Nisim Hananel, Lital Shemesh-Bar, Tzipora Shohat, Aaron Sulkes, Baruch Brenner
Journal: Journal of Clinical Oncology (2015)

e14594 Background: The incidence of colorectal cancer (CRC) in young patients (pts) has increased significantly in the last decade. Several studies, including from our group, have evaluated whether CRC in young pts has unique features, with conflicting results. The aim of our study was to compare various characteristics of CRC between young and older pts, while emphasizing potential differences through a younger age cutoff and a larger database. Methods: This was a single center retrospective case control study. We searched our institutional database for all CRC pts 40 years old or younger who were diagnosed between 1997 and 2013. A control group consisted of consecutive pts older than 50 years at CRC diagnosis during the same period. These pts were matched to the study group by their year of diagnosis in a 1:2 ratio. Data on demographics, predisposing risk factors, clinical presentation, disease characteristics, treatment and outcome were compared between groups. Results: A total of 330 pts were included: 110 young pts and 220 pts in the control group. The median follow up was 65.9 months (range: 4.7-211). Pts in the younger group had a different ethnic composition, with fewer Ashkenazi Jews (p = 0.0006) and more Arabs (p < 0.0001), increased prevalence of family history of cancer (p = 0.004), hereditary CRC syndromes (p < 0.0001) and inflammatory bowel disease (p = 0.007), and lower incidence of polyps (p < 0.0001). The younger group also had different distribution of tumor location and histological sub-types. They were more likely to present with stage III or IV disease (p = 0.001) and had a higher rate of venous and lymphatic invasion in their tumor. They more commonly received treatment, and treatment was more aggressive. The 5-year overall survival (OS) rate were 59.1% and 62.1% in the younger and the control group, respectively (p = 0.57). Interestingly, while the 5-year disease free survival (DFS) was significantly worse for younger pts (57.6% vs. 70%, p = 0.039), young pts with metastatic disease had a trend for a better 5-year OS rate (36.5% vs. 16.5%, p = 0.198). Conclusions: Our data suggest that CRC in pts 40 years old or younger at diagnosis may represent a distinct clinical entity. Further research to define the optimal approach for young CRC pts is clearly needed.
Assessment of Tumor Response with MRI and CT After Radioembolization
Authors: Thomas C. Lauenstein, Juliane Schelhorn, Sonja Kinner
Journal: Clinical Nuclear Medicine (2020)

The assessment of therapeutic success is crucial in almost every form of medical therapy. As selective internal radiation therapy is a new therapeutic tool, there is still no consensus about the best way to evaluate tumor response. Imaging plays a key role beyond clinical and laboratory markers. There is a paradigm shift from using mere morphologic and anatomic parameters to the application of functional biomarkers including perfusion and diffusion analysis. We discuss in this chapter the value, but also limitations of CT and MRI as cross-sectional imaging for tumor response evaluation.
Peer Influence in Adolescence: Public-Health Implications for COVID-19
Authors: Jack L. Andrews, Lucy Foulkes, Sarah-Jayne Blakemore
Journal: Trends in Cognitive Sciences (2020)

The coronavirus disease 2019 (COVID-19) pandemic has resulted in the widespread implementation of social distancing measures. Adhering to social distancing may be particularly challenging for adolescents, for whom interaction with peers is especially important. We argue that young people's capacity to encourage each other to observe social distancing rules should be harnessed.
Circular RNA circCCDC9 acts as a miR-6792-3p sponge to suppress the progression of gastric cancer through regulating CAV1 expression
Authors: Zai Luo, Zeyin Rong, Jianming Zhang, Zhonglin Zhu, Zhilong Yu, Tengfei Li, Zhongmao Fu, Zhengjun Qiu, Chen Huang
Journal: Molecular Cancer (2020)

Abstract Background As a novel type of noncoding RNAs, covalently closed circular RNAs (circRNAs) are ubiquitously expressed in eukaryotes. Emerging studies have related dysregulation of circRNAs to tumorigenesis. However, the biogenesis, regulation, function and mechanism of circRNAs in gastric cancer (GC) remain largely unclear. Methods The expression profile of circRNAs in 6 pairs of GC tissues and adjacent non-tumor tissues was analyzed by RNA-sequencing. Quantitative real-time PCR was used to determine the expression level of circCCDC9 in GC tissues and cell lines. Then, functional experiments in vitro and in vivo were employed to explore the effects of circCCDC9 on tumor growth and metastasis in GC. Mechanistically, dual luciferase reporter, fluorescence in situ hybridization (FISH), RNA immunoprecipitation (RIP) and RNA pull-down assays were performed to confirm that circCCDC9 directly sponged miR-6792-3p and alleviated suppression on target CAV1 expression. Results Evidently down-regulated expression of circCCDC9 was observed in both GC tissues and cell lines. Expression of circCCDC9 was negatively correlated with tumor size, lymph node invasion, advanced clinical stage and overall survival in GC patients. Functionally, overexpression of circCCDC9 significantly inhibited the proliferation, migration and invasion of GC cell lines in vitro and tumor growth and metastasis in vivo, whereas miR-6792-3p mimics counteracted these effects. Mechanistic analysis demonstrated that circCCDC9 acted as a “ceRNA” of miR-6792-3p to relieve the repressive effect of miR-6792-3p on its target CAV1, then suppressed the tumorigenesis of GC. Conclusions CircCCDC9 functions as a tumor suppressor in inhibiting the progression of GC through miR-6792-3p/CAV1 axis, which has provided an exploitable biomarker and therapeutic target for patients with GC.
Abstract 11776: Preoperative Disturbances of Glucose Metabolism and Mortality After Coronary Artery Bypass Grafting
Authors: Catarina Djupsjo, Ulrik Sartipy, Torbjorn Ivert, Stelios Karayiannides, Pia Lundman, Thomas Nystrom, Martin J Holzmann, Jeanette Kuhl
Journal: Circulation (2019)

Hypothesis: Disturbances of glucose metabolism are important risk factors for coronary artery disease and an increased mortality risk. The aim was to investigate the association between preoperativ...