tbuckley/cabot-search huggingface dataset:
Outcomes for patients with borderline resectable (BR) and locally advanced (LA) pancreatic cancer (PC) treated with induction FOLFIRINOX (FFX) +/- radiation (RT) followed by surgery compared to induction FFX followed by consolidative RT.
Authors: Michael Cecchini, Joseph Miccio, Jay Pahade, Jill Lacy, Ronald R Salem, Skyler Bryce Johnson, Stacey Stein, Jeremy S. Kortmansky, Kimberly Johung
Journal: Journal of Clinical Oncology (2019)

437 Background: Induction FFX for PC deemed either BR or LA at diagnosis provides an opportunity to downstage pts with the aim of an R0 surgery. The addition of RT after induction FFX may further downstage. However, there is a paucity of data regarding long-term survival for BR and LA patients successfully downstaged and resected. We performed a retrospective review of BR and LA PC treated with induction FFX +/- RT followed by surgery or consolidative RT at the Yale Cancer Center (YCC) to assess survival in these two cohorts. Methods: Clinical data was abstracted for pts with BR or LA PC who had surgery or received consolidative RT without surgery after induction FFX +/- RT at the YCC from 2010-2018. Surgical pts were re-reviewed by a radiologist to assess vascular involvement (BR vs. LA) using NCCN criteria. PFS and OS for surgery and consolidative RT were analyzed by the Kaplan-Meier method. Survival was compared via the log rank test. Results: 102 pts met inclusion criteria (BR=47, LA=55), 41 pts had surgery [BR=29/47 (62%) LA=12/55 (22%)] and 61 pts had consolidative RT [(BR= 18/47 (38%), LA= 43/55 (78%)] after induction FFX. 18 surgery pts received RT prior to resection and all surgery pts had R0 resection. Median follow up was 25 mo (range 5 – 97). Median PFS with surgery was 22 mo (95% CI 15 – 59) vs 14 mo (95% CI 10.9 – 20.1) with consolidative RT (p&lt;0.001), while OS with surgery was 42 mo (95% CI 25-NR) vs 20 mo (95% CI 17-25) without surgery (p&lt;0.001). For pts with ≥ 2 yr follow up, 12/22 (55%) surgery pts and 17/18 (94%) consolidative RT pts relapsed. For pts with ≥ 3 yr follow up, 6/12 (50%) surgery pts and 10/10 (100%) consolidative RT pts relapsed. 2 yr PFS and OS was 45% (95% CI 28-61) and 74% (95% CI 57 – 86) with surgery versus 15% (95% CI 7-27) and 40% (95% CI 26-53) with consolidative RT. Conclusions: Surgery was associated with a high R0 rate and prolonged PFS and OS compared to consolidative RT in pts with BR and LA PC after FFX +/- RT. However, survival benefit was not statistically significant when selecting only LA pts although numbers are limited.
Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured by Positron Emission Tomography in Clinically Normal Older Adults
Authors: Rachel F. Buckley, Elizabeth C. Mormino, Jennifer S. Rabin, Timothy J. Hohman, Susan Landau, Bernard J. Hanseeuw, Heidi I. L. Jacobs, Kathryn V. Papp, Rebecca E. Amariglio, Michael J. Properzi, Aaron P. Schultz, Dylan Kirn, Matthew R. Scott, Trey Hedden, Michelle Farrell, Julie Price, Jasmeer Chhatwal, Dorene M. Rentz, Victor L. Villemagne, Keith A. Johnson, Reisa A. Sperling
Journal: JAMA Neurology (2019)

<h3>Importance</h3> Mounting evidence suggests that sex differences exist in the pathologic trajectory of Alzheimer disease. Previous literature shows elevated levels of cerebrospinal fluid tau in women compared with men as a function of apolipoprotein E (APOE) ε4 status and β-amyloid (Aβ). What remains unclear is the association of sex with regional tau deposition in clinically normal individuals. <h3>Objective</h3> To examine sex differences in the cross-sectional association between Aβ and regional tau deposition as measured with positron emission tomography (PET). <h3>Design, Setting and Participants</h3> This is a study of 2 cross-sectional, convenience-sampled cohorts of clinically normal individuals who received tau and Aβ PET scans. Data were collected between January 2016 and February 2018 from 193 clinically normal individuals from the Harvard Aging Brain Study (age range, 55-92 years; 118 women [61%]) who underwent carbon 11–labeled Pittsburgh Compound B and flortaucipir F<sup>18</sup>PET and 103 clinically normal individuals from the Alzheimer's Disease Neuroimaging Initiative (age range, 63-94 years; 55 women [51%]) who underwent florbetapir and flortaucipir F 18 PET. <h3>Main Outcomes and Measures</h3> A main association of sex with regional tau in the entorhinal cortices, inferior temporal lobe, and a meta-region of interest, which was a composite of regions in the temporal lobe. Associations between sex and global Aβ as well as sex and APOE ε4 on these regions after controlling for age were also examined. <h3>Results</h3> The mean (SD) age of all individuals was 74.2 (7.6) years (81 APOE ε4 carriers [31%]; 89 individuals [30%] with high Aβ). There was no clear association of sex with regional tau that was replicated across studies. However, in both cohorts, clinically normal women exhibited higher entorhinal cortical tau than men (meta-analytic estimate: β [male] = −0.11 [0.05]; 95% CI, −0.21 to −0.02;<i>P</i> = .02), which was associated with individuals with higher Aβ burden. A sex by APOE ε4 interaction was not associated with regional tau (meta-analytic estimate: β [male, APOE ε4+] = −0.15 [0.09]; 95% CI, −0.32 to 0.01;<i>P</i> = .07). <h3>Conclusions and Relevance</h3> Early tau deposition was elevated in women compared with men in individuals on the Alzheimer disease trajectory. These findings lend support to a growing body of literature that highlights a biological underpinning for sex differences in Alzheimer disease risk.
Abstract 18537: Fever in Post-Cardiac Arrest Patients Treated in the Pediatric Intensive Care Unit
Authors: Amy E Manzo, Jordan Duval-Arnould, Sara I Jones, Heather M Newton, Melania M Bembea, Elizabeth A Hunt
Journal: Circulation (2017)

Introduction: Fever in pediatric post-cardiac arrest patients is believed to negatively impact neurologic outcome. Current AHA PALS Guidelines suggest targeting normothermia and aggressive treatmen...
The IASLC Mesothelioma Staging Project: Proposals for Revisions of the T Descriptors in the Forthcoming Eighth Edition of the TNM Classification for Pleural Mesothelioma
Authors: Anna K. Nowak, Kari Chansky, David C. Rice, Harvey I. Pass, Hedy L. Kindler, Lynn Shemanski, Andrea Billé, Robert C. Rintoul, Hasan F. Batirel, Charles F. Thomas, Joseph Friedberg, Susana Cedres, Marc de Perrot, Valerie W. Rusch, Peter Goldstraw, Ramón Rami-Porta, Hisao Asamura, David Ball, David Beer, Ricardo Beyruti, Vanessa Bolejack, Kari Chansky, John Crowley, Frank Detterbeck, Wilfried Ernst Erich Eberhardt, John Edwards, Françoise Galateau-Sallé, Dorothy Giroux, Fergus Gleeson, Patti Groome, James Huang, Catherine Kennedy, Jhingook Kim, Young Tae Kim, Laura Kingsbury, Haruhiko Kondo, Mark Krasnik, Kaoru Kubota, Antoon Lerut, Gustavo Lyons, Mirella Marino, Edith M. Marom, Jan van Meerbeeck, Alan Mitchell, Takashi Nakano, Andrew G. Nicholson, Anna Nowak, Michael Peake, Thomas Rice, Kenneth Rosenzweig, Enrico Ruffini, Valerie Rusch, Nagahiro Saijo, Paul Van Schil, Jean-Paul Sculier, Lynn Shemanski, Kelly Stratton, Kenji Suzuki, Yuji Tachimori, Charles F. Thomas, William Travis, Ming S. Tsao, Andrew Turrisi, Johan Vansteenkiste, Hirokazu Watanabe, Yi-Long Wu, Paul Baas, Jeremy Erasmus, Seiki Hasegawa, Kouki Inai, Kemp Kernstine, Hedy Kindler, Lee Krug, Kristiaan Nackaerts, Harvey Pass, David Rice, Conrad Falkson, Pier Luigi Filosso, Giuseppe Giaccone, Kazuya Kondo, Marco Lucchi, Meinoshin Okumura, Eugene Blackstone, H. Asamura, H. Batirel, A. Bille, U. Pastorino, S. Call, A. Cangir, S. Cedres, J. Friedberg, F. Galateau-Salle, S. Hasagawa, K. Kernstine, H. Kindler, B. McCaughan, T. Nakano, A. Nowak, C. Atinkaya Ozturk, H. Pass, M. de Perrot, F. Rea, D. Rice, R. Rintoul, E. Ruffini, V. Rusch, L Spaggiari, D Galetta, K. Syrigos, C. Thomas, J. van Meerbeeck, P. Nafteux, J. Vansteenkiste, W. Weder, I. Optiz, M. Yoshimura
Journal: Journal of Thoracic Oncology (2016)
Communal sharing/identity fusion does not require reflection on episodic memory of shared experience or trauma – and usually generates kindness
Authors: Lotte Thomsen, Alan P. Fiske
Journal: Behavioral and Brain Sciences (2018)

Abstract Identity fusion is remarkably similar to the extensively validated construct of communal sharing, proposed in 1991. Both posit that notions of oneness/unity/equivalence with others underpin altruism. However, we argue that oneness/equivalence instantiates an evolved, innate relational form, marked and constituted by cultural practices making participants’ bodies substantially the same. It is intuitive from earliest development, often encompasses persons whom one has never met, and results mostly in caring.
Measles cases in Europe tripled from 2017 to 2018
Authors: Jacqui Thornton
Journal: BMJ (2019)

More than 80 000 people in 47 of 53 European countries contracted measles in 2018, with 72 deaths, the World Health Organization has said.1 In countries reporting hospitalisation data 61% of patients with measles were admitted to hospital.2

The total number of people infected with the virus in 2018 was the highest this decade,1 three times the total reported in 2017 (23 927 cases) and 15 times the record low recorded in 2016 (5273 cases).3

Despite more children in the WHO European region being vaccinated against the disease than ever before, progress on vaccination is uneven between and within countries. This leaves clusters of susceptible people unprotected, particularly …
Abstract 19532: Echocardiographic Predictors of Ductus Arteriosus Related Branch Pulmonary Artery Stenosis in Patients With Pulmonary Atresia
Authors: Marisha McClean, Timothy Colen, Mohammed Al Aklabi, Lisa Hornberger
Journal: Circulation (2017)

Background: Branch pulmonary artery (PA) stenosis due to ductus arteriosus tissue (DA-PS) contributes to morbidity and mortality associated with pulmonary atresia (PAtr). As preoperative predictors of DA-PS in PAtr remain poorly defined, we sought to identify preoperative echo features that predict DA-PS in PAtr. Methods: Neonates with PAtr and a ductal-dependent pulmonary circulation surgically managed in our program from 2009-2015 were included. DA-PS was diagnosed as a discrete proximal stenosis of the branch PA ipsilateral to the DA requiring intervention. Preoperative echocardiograms were reviewed to assess 3 features: 1) proximal branch PA diameters, 2) an abnormal relationship between the branch PAs (an inability to image their origins on the same plane), 3) a horizontal course of the ipsilateral PA with a more obtuse posterior angle between the branch PAs. Following review of their clinical course, comparisons were made between those with and without DA-PS. Results: Seventy-six patients met inclus...
Cancer survival data emphasise importance of early diagnosis
Authors: Nigel Hawkes
Journal: BMJ (2019)

Robust cancer survival estimates according to stage at diagnosis have been published by the Office for National Statistics for the first time.1

They show, as expected, that for most cancers survival at one and five years is much higher if the cancer is detected early (at stage 1) than if it is detected later. This re-emphasises the need for early diagnosis.

For some cancers, however, the stage of detection is less important. Prostate cancer, for example, has extremely high one year survival rates (around 100%) whether it is detected in stages 1, 2, or 3, falling to 87.6% if detected in stage 4. Five year survival follows a similar but steeper decline—100% or near for stages …
Reduced Intensity Conditioning (RIC) Regimens Hematopoietic Cell Transplantation (HCT) for Acute Myeloid Leukemia (AML): A Comparison of Fludarabine/Busulfan (FB) and Fludarabine/Melphalan (FM) Based Regimens from the CIBMTR
Authors: Rajneesh Nath, Zheng Zhou, Jan Cerny, Hai-Lin Wang, Khalid Bo-Subait, Zartash Guth, Gulrayz Ahmed, Muhammad Wagas Khan, Gerhard Carl Hildebrandt, Hassan B. Alkhateeb, Moussab Damlaj, Mrinal M. Patnaik, Brenda M. Sandmaier, Daniel J. Weisdorf, Marcos de Lima, Mark R. Litzow, Wael Saber
Journal: Blood (2018)
Abstract 34: Effects of the DASH Diet and Sodium Intake on Serum Uric Acid
Authors: Stephen P Juraschek, Allan C Gelber, Lawrence J Appel, Edgar R Miller
Journal: Circulation (2016)

Background: Elevated serum uric acid (SUA) is etiologically related to the occurrence of gout and is associated with an increased risk of cardiovascular disease. Dietary recommendations for SUA reduction are largely based on observational studies. In an ancillary study to the DASH-Sodium feeding study conducted at the Johns Hopkins clinical center (N=103), we examined the effects of the DASH diet and of sodium intake on SUA levels. Methods: The DASH-Sodium trial was a randomized, crossover feeding trial among adults without cardiovascular disease not using antihypertensive medications. Participants were randomly assigned to either a control diet or the DASH diet; during both diets, participants were fed each of three sodium levels in random order in 4-week periods separated by 5-day breaks. Body weight was held constant. The three sodium levels were: low (50 mmol/d), medium (100 mmol/d), and high (150 mmol/d). SUA was measured at baseline and after each feeding period, allowing for comparisons by diet (DASH vs control) and sodium levels. Results: Trial participants were 55% women and 76% black; mean age was 52 years (SD, 10) and mean SUA was 5.0 mg/dL (SD, 1.3). Mean baseline alcohol intake was low at 1.3 g/day. Compared with the control diet, the DASH diet reduced SUA by -0.35 mg/dL (95% CI: -0.65, -0.05; P = 0.02). Among participants with a baseline SUA ≥6 and &lt;7 mg/dL (N=16), the mean effect was -0.8 mg/dL; among participants (N=8) with a baseline SUA ≥7 mg/dL the mean effect was -1.3 mg/dL (P-interaction = 0.04) (Figure). Compared to the low sodium intake, the medium sodium intake lowered SUA by -0.3 mg/dL (95% CI: -0.5, -0.2; P &lt; 0.001) and the high sodium intake lowered SUA by -0.4 mg/dL (95% CI: -0.6, -0.3; P &lt; 0.001). The effects of sodium intake on SUA were greater among participants with high blood pressure at baseline (P-interaction = 0.02, see Figure). Conclusions: This study demonstrates that the DASH diet lowers SUA, that this effect differs by sodium level, and that SUA reduction is greatest in those with hyperuricemia at baseline.
Evaluation of Eosinophilic Asthma Patients Without Blood Eosinophil (EOS) Response to Intravenous (IV) Reslizumab in a Post-Hoc Analysis of 52-Week Placebo-Controlled Phase 3 Studies
Authors: Pascal Chanez, Lisa Hickey, Margaret Garin, Mario Castro
Journal: Journal of Allergy and Clinical Immunology (2019)
Standard chop with reduced dose of doxorrubicin (minichop) for elderly patients with intermediate and high non hodgkin's lymphoma (nhl)
Authors: M. C. M. A. Macedo, M Ostronoff, R Silva, B L Boehringer, E Zambon, M Conhon, R S Medeiros, Frederico Luiz Dulley, C M Matsumoto, Pedro Enrique Dorlhiac Llacer, Diana Helena de Benedetto Pozzi, Dalton de Alencar Fischer Chamone
Journal: Blood (1994)
T Cells Engineered with T Cell Antigen Coupler (TAC) Receptors for Haematological Malignancies
Authors: Christopher Helsen, Vivian Lau, Joanne Hammill, Kenneth Mwawasi, Danielle Hayes, Arya Afsahi, Ksenia Bezverbnaya, Craig Aarts, Galina Denisova, Jonathan Bramson
Journal: Blood (2018)
Twins with different personalities: STAT5B—but not STAT5A—has a key role in BCR/ABL-induced leukemia
Authors: Sebastian Kollmann, Eva Grundschober, Barbara Maurer, Wolfgang Warsch, Reinhard Grausenburger, Leo Edlinger, Jani Huuhtanen, Sabine Lagger, Lothar Hennighausen, Peter Valent, Thomas Decker, Birgit Strobl, Mathias Mueller, Satu Mustjoki, Andrea Hoelbl-Kovacic, Veronika Sexl
Journal: Leukemia (2019)

Deregulation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway is found in cancer with STAT5A/B controlling leukemic cell survival and disease progression. As mutations in STAT5B, but not STAT5A, have been frequently described in hematopoietic tumors, we used BCR/ABL as model systems to investigate the contribution of STAT5A or STAT5B for leukemogenesis. The absence of STAT5A decreased cell survival and colony formation. Even more drastic effects were observed in the absence of STAT5B. STAT5B-deficient cells formed BCR/ABL+ colonies or stable cell lines at low frequency. The rarely evolving Stat5b−/− cell lines expressed enhanced levels of BCR/ABL oncoprotein compared to wild-type cells. In line, Stat5b−/− leukemic cells induced leukemia with a significantly prolonged disease onset, whereas Stat5a−/− cells rapidly caused a fatal disease superimposable to wild-type cells. RNA-sequencing (RNA-seq) profiling revealed a marked enhancement of interferon (IFN)-α and IFN-γ signatures in Stat5b−/− cells. Inhibition of IFN responses rescued BCR/ABL+ colony formation of Stat5b−/−-deficient cells. A downregulated IFN response was also observed in patients suffering from leukemia carrying STAT5B mutations. Our data define STAT5B as major STAT5 isoform driving BCR/ABL+ leukemia. STAT5B enables transformation by suppressing IFN-α/γ, thereby facilitating leukemogenesis. Our findings might help explain the high frequency of STAT5B mutations in hematopoietic tumors.
Glucose Management Indicator (GMI): Insights and Validation Using Guardian 3 and Navigator 2 Sensor Data
Authors: Lalantha Leelarathna, Roy W. Beck, Richard M. Bergenstal, Hood Thabit, Roman Hovorka
Journal: Diabetes Care (2019)

The glucose management indicator (GMI) is an updated approach for estimating HbA1c from continuous glucose monitoring (CGM) data (1). GMI is calculated using the formula GMI (%) = 3.31 + 0.02392 × mean glucose in mg/dL, which has been derived by regressing contemporaneously measured HbA1c values ( y -axis) against mean sensor glucose levels ( x -axis). GMI was conceived using data collected solely with Dexcom glucose sensors; thus, generalization and validation of the formula for other sensor makes is currently unknown (1). Here, we assessed GMI using Guardian Sensor 3 (Guardian 3) (Medtronic Inc., Northridge, CA) and Freestyle Navigator II (Navigator 2) (Abbott Diabetes Care, Alameda, CA) glucose sensors and evaluated the difference between GMI and laboratory-measured HbA1c values.

We used data from three recently published 12-week randomized controlled trials evaluating the safety and effectiveness of closed-loop in comparison with sensor-augmented pump therapy in adults and children with type 1 diabetes and HbA1c between 7.5% and 10% (58 and 86 mmol/mol): APCam11 (Home Testing of Day and Night Closed Loop With Pump Suspend Feature) ( n = 86, Guardian 3) (2), AP@home04 (Closing the Loop in Adults With Sub-optimally Controlled Type …
Classification of BRAF mutated colorectal cancer based on microsatellite stability.
Authors: Michitaka Nakano, Kosuke Sagara, Sakuya Koreishi, Tomomi Aikawa, Tomohiro F. Nishijima, Kotoe Takayoshi, Masato Komoda, Eishi Baba, Taito Esaki
Journal: Journal of Clinical Oncology (2019)

553 Background: BRAF mutated metastastic colorectal cancer (CRC) shows poor outcome in spite of development of the treatment. Thus, classification of BRAF mutated CRC based on therapeutic target is warranted. Particularly, about half of the BRAF mutated CRC reveals high microsatellite instability (MSI-H) that is characterized by high mutation burden and frequent infiltration of lymphocytes. Hence, the patients with BRAF mutation carrying MSI-H would potentially benefit from immune-check point inhibitor. However, the precise evaluation of immune status of these patients has not been clarified. Furthermore, the character of BRAF mutation with microsatellite stability (MSS) is not fully investigated. Methods: Transcriptomic information of BRAF mutated CRC with MSS/MSI-H was downloaded from open database, Gene Expression Omnibus (GEO); GSE75316 (n = 59), GSE35896 (n = 62), GSE39582 (n = 585). Gene expression of BRAF mutation with MSI-H/MSS (GSE75316: n = 5/3, GSE35896: n = 1/5, GSE39582: n = 31/14) were normalized and differentially expressed genes were identified by using GeneSpring (Agilent technologies). Pathway analysis was performed by GSEA. Results: Pathway analysis revealed datasets regarding cytotoxic T cell (FDR q value: 0.09), helper T cell (FDR q value: 0.05), natural killer T cell (FDR q value: 0.11), and activated inflammatory response (FDR q value: 0.16) were significantly enriched in BRAF mutation with MSI-H. (FDR q value &lt; 0.25 means significant). The differentially expressed genes were identified in both of 2 groups. Significantly high expression of Granzyme A, Granzyme B, and Perforin were observed in BRAF mutated MSI-H. At the same time, highly expressed genes including MLH1 were identified in BRAF mutated MSS. Conclusions: High infiltration of cytotoxic T cells was suggested by the pathway analysis and expression of Granzayme A, B, and Perforin among BRAF mutated MSI-H. The activated immune status within these patients suggested the potential response of immune-checkpoint inhibitors. Furthermore, our data would give us a clue in considering the therapeutic strategy against BRAF mutated MSS, that will be the remained population among BRAF mutated CRC to which effective treatment have not been established.
Abstract 17416: The DNMT-1/miR-424-Dependant Upregulation of CHK1 in PAH-PASMCs is Essential for Proliferation and Survival by Preventing Excessive Replication Stress
Authors: Thibaut Peterlini, Sandra Breuils-Bonnet, Nolwenn Samson, Marie-Claude Lampron, Steeve Provencher, Olivier Boucherat, Sébastien Bonnet
Journal: Circulation (2017)

Rationale: Pulmonary arterial hypertension (PAH) is a vascular remodeling disease with a poor prognosis and no therapeutic option. It is now established that excessive proliferation and resistance to apoptosis of pulmonary artery smooth muscle cells (PASMCs) is a pivotal component of pulmonary vascular remodelling. Given that PAH and cancer cells share numerous similarities, this opens the possibility of exploiting therapeutic agents used in cancer to treat PAH. Cancer cells presenting intrinsic elevated replication stress (RS) rely on activation of the DNMT-1/miR-424/CHK1 pathway to restrain the accumulation of deleterious levels of DNA damage. CHK1 activation results in cell cycle arrest, DNA repair and finally, when stress is resolved, allows replication to resume. Objective: We hypothesize that PAH-PASMCs have developed an orchestrated response mediated by CHK1 to overcome RS/DNA damage, allowing survival and proliferation and thus contributing to vascular remodeling. Methods and Results: Using Wester...
Cardiovascular toxicities associated with immune checkpoint inhibitors
Authors: Jiun-Ruey Hu, Roberta Florido, Evan J Lipson, Jarushka Naidoo, Reza Ardehali, Carlo G Tocchetti, Alexander R Lyon, Robert F Padera, Douglas B Johnson, Javid Moslehi
Journal: Cardiovascular Research (2019)

Cardiovascular toxicities associated with immune checkpoint inhibitors (ICIs) have been reported in case series but have been underappreciated due to their recent emergence, difficulties in diagnosis and non-specific clinical manifestations. ICIs are antibodies that block negative regulators of the T cell immune response, including cytotoxic T lymphocyte-associated protein-4 (CTLA-4), programmed cell death protein-1 (PD-1), and PD-1 ligand (PD-L1). While ICIs have introduced a significant mortality benefit in several cancer types, the augmented immune response has led to a range of immune-related toxicities, including cardiovascular toxicity. ICI-associated myocarditis often presents with arrhythmias, may co-exist with myositis and myasthenia gravis, can be severe, and portends a poor prognosis. In addition, pericardial disease, vasculitis, including temporal arteritis, and non-inflammatory heart failure, have been recently described as immune-related toxicities from ICI. This narrative review describes the epidemiology, diagnosis, pathophysiology, and treatment of cardiovascular toxicities of ICI therapy, highlighting recent developments in the field in the past year.