tbuckley/cabot-search huggingface dataset:
EFFICACY OF THE DIAGNOSTIC ACCURACY USING MAGNIFYING ENDOSCOPY WITH NARROW-BAND IMAGING FOR PURE SIGNET RING CELL CARCINOMA AND POORLY DIFFERENTIATED-TYPE COMPONENT MIXED WITH UNDIFFERENTIATED-TYPE ADENOCARCINOMA
Authors: M Inuyama, Y Horiuchi, J Fujisaki
Journal: Endoscopy (2020)

Aims Intramucosal undifferentiated-type early gastric cancers measuring < 2 cm without ulcers or scars, are positioned for the expanded indication of endoscopic submucosal dissection (ESD). However, the undifferentiated-type have been reported to have low curative resection rates compared with the differentiated-type. We have already reported that pure signet ring cell carcinomas (pure-sig) have higher curability rates than undifferentiated-type adenocarcinomas component mixed with poorly differentiated-type (mixed-por). Mixed-por is an important factor for the non-curability of undifferentiated-type adenocarcinomas. Therefore, we investigated the diagnostic accuracy of magnifying endoscopy narrow-band imaging (ME-NBI) for pure-sig and mixed-por.
UNDERWATER COLD SNARE POLYPECTOMY FOR IMPROVING OF COMPLETE RESECTION RATE AND RETRIEVAL RATE IN SMALL COLORECTAL POLYPS
Authors: Y Myung
Journal: Endoscopy (2020)

Aims Cold snare polypectomy (CSP) has been reported as safe and effective method for the removal of small colorectal polyps. However, some studies showed low histologic complete resection rate due to damage to specimens retrieved via suction and high retrieval failure. Underwater endoscopic mucosal resection (EMR) is an effective technique to increase the proportions of complete resection without increasing adverse events or procedure time. Therefore, the aim of this study was to compare the complete resection rate and retrieval rate between conventional CSP (C-CSP) and underwater CSP (U-SCP).
COLORECTAL (CR) ENDOSCOPIC SUBMUCOSAL DISSECTION (ESD) IN WESTERN COUNTRIES WHEN HISTOLOGY SHOWS LOW GRADE DYSPLASIA: IS THE RISK ACCEPTABLE?
Authors: JC Marín-Gabriel, AH de Tejada, F Ramos-Zabala, E Albéniz-Arbizu, Á Terán-Lantarón, PJ Rosón-Rodríguez, A Amorós-Tenorio, GR Diana, RS Joaquín, H Uchima-Koecklin, J Santiago-García, A Sánchez-Yagüe, G Fernández-Esparrach, Ó Nogales-Rincón, C Guarner-Argente, P de María, C Dolz-Abadía, ER de Santiago, A del Pozo-García, A Álvarez-Delgado, H Cortés-Pérez, R Durán-Bermejo
Journal: Endoscopy (2020)

Aims The ESGE has recently published a curriculum for ESD training in Europe. However, there are no recommendations concerning the maximum acceptable percentage of lesions with histology showing Vienna category ≤ 3. This quality measure seems relevant because colonic perforation after EMR of LSLs occurs in 1-2% cases and related surgery is seldom needed (0.1%).
POST ENDOSCOPIC SUBMUCOSAL DISSECTION (ESD) STRICTURES - IS RISK RELATED TO PATHOLOGY? A EUROPEAN COMPARISON OF BARRETT’S VERSUS SQUAMOUS NEOPLASIA
Authors: S Arndtz, S Subramaniam, A Alkandari, E Hossain, M Abdelrahim, PA Galtieri, G Pellegatta, S Seewald, R Maselli, A Repici, P Bhandari
Journal: Endoscopy (2020)

Aims ESD is a minimally invasive therapeutic option for early oesophageal neoplasia, however is not without risk. In Europe, the complication profile is most established for Barrett’s neoplasia, being the predominant pathology, and stricture risk has been shown to be related to lesion circumference. Our aim was to compare the safety of ESD between Barrett’s and squamous neoplasia in a Western population.
LONG-TERM OUTCOMES AFTER UNDERWATER ENDOSCOPIC MUCOSAL RESECTION VERSUS ENDOSCOPIC SUBMUCOSAL DISSECTION FOR 20-30 MM SIZED COLORECTAL LESIONS: A PROPENSITY SCORE-MATCHED STUDY
Authors: T Inoue, K Nakagawa, Y Yamasaki, S Shichijo, N Uedo, R Ishihara, Y Takeuchi
Journal: Endoscopy (2020)

Aims Endoscopic submucosal dissection (ESD) has been widely performed for large colorectal polyps in Japan. On the other hand, underwater endoscopic mucosal resection (UEMR) can be an alternative promising endoscopic resection (ER) method for large colorectal lesions. However, there is no direct comparison between ESD and UEMR for large colorectal lesion. In this study, we aimed to evaluate the efficiency of UEMR for 20-30 mm sized colorectal lesions, compared with ESD.
Oral Direct Factor Xa Inhibitors Versus Low-Molecular-Weight Heparin to Prevent Venous Thromboembolism in Patients Undergoing Total Hip or Knee Replacement
Authors: Ignacio Neumann, Gabriel Rada, Juan Carlos Claro, Alonso Carrasco-Labra, Kristian Thorlund, Elie A. Akl, Shannon M. Bates, Gordon H. Guyatt
Journal: Annals of Internal Medicine (2020)

Several strategies to prevent venous thromboembolism are available for patients undergoing major orthopedic surgery. This systematic review examined 22 trials that compared oral factor Xa inhibitor...
Determining the Noninfectious Complications of Indwelling Urethral Catheters
Authors: John M. Hollingsworth, Mary A.M. Rogers, Sarah L. Krein, Andrew Hickner, Latoya Kuhn, Alex Cheng, Robert Chang, Sanjay Saint
Journal: Annals of Internal Medicine (2013)

Little is known about noninfectious complications resulting from urethral catheter use. This systematic review and meta-analysis examined studies describing such complications and pooled data to es...
The Human T-Cell Receptor
Authors: Stefan C. Meuer, Oreste Acuto, Thierry Hercend, Stuart F. Schlossman, Ellis L. Reinherz
Journal: Annual Review of Immunology (1984)

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, ...Read More
The State of Ophthalmology Medical Student Education in the United States: An Update
Authors: Nathaniel R. Moxon, Anju Goyal, JoAnn A. Giaconi, Jamie B. Rosenberg, Emily B. Graubart, Evan L. Waxman, Daniel Knoch, Susan H. Forster, Privthi S. Sankar, Rukhsana G. Mirza
Journal: Ophthalmology (2020)
Reply to: “Comment on ‘Bullous pemphigoid after anti–PD-1 therapy: A retrospective case-control study evaluating impact on tumor response and survival outcomes’”
Authors: Caroline A. Nelson, Sean Singer, Tianqi Chen, Ashleigh Eberly Puleo, Christine G. Lian, Erin X. Wei, Anita Giobbie-Hurder, Arash Mostaghimi, Nicole R. LeBoeuf
Journal: Journal of the American Academy of Dermatology (2020)
POSITIVE PREDICTIVE VALUE OF MAIN PANCREATIC DUCT DILATION FOR MALIGNANCY PREDICTION IN SOLID PANCREATIC MASSES: A SINGLE-CENTER RETROSPECTIVE ANALYSIS
Authors: C Robles-Medranda, C Torella, R Oleas, M Puga-Tejada, J Baquerizo-Burgos, H Pitanga-Lukashok
Journal: Endoscopy (2020)

Aims To evaluate the association between main pancreatic duct (MPD) dilation and malignancy occurrence in pancreatic solid lesions during endoscopic ultrasound (EUS).
ENDOSCOPIC TREAMTMENT OF COMPLETE ESOPHAGEAL OBSTRUCTION: A COMPARISON BETWEEN TWO DIFFERENT APPROACHES
Authors: T Rath, F Vitali, A Nägel, J Siebler, MF Neurath
Journal: Endoscopy (2020)

Aims The development of esophageal stricture is frequently observed after radiochemoherapy (RCT). At the same time, with an incidence < 1%, complete esophageal obstruction is a rare complication of RCT. Nevertheless, complete obstruction is associated with significant impairment in the quality of life and renders patients susceptible for the development of secondary conditions such as aspiration pneumonia. Within this study,compared the outcome of two different techniques for lumen restoration of a completely obstructed esophagus.
Commentary on“The relationship between anesthetic technique and thirty-day mortality in patients undergoing noncardiac- and nonneurosurgery: A retrospective, propensity score-matched cohort study” (Int. J. Surg. 77 (2020) 120–127)
Authors: Fu-Kun Liu, Fu-Shan Xue, Yi Cheng, Yu-Jing Yuan
Journal: International Journal of Surgery (2020)
FEASIBILITY AND OPTIMIZATION OF RNA EXTRACTION FROM EUS-ACQUIRED TISSUE IN PANCREATIC CANCER
Authors: L Archibugi, SGG Testoni, M Redegalli, MC Petrone, G Rossi, M Falconi, M Reni, C Doglioni, G Capurso, PG Arcidiacono
Journal: Endoscopy (2020)

Aims Pancreatic cancer (PDAC) is the 2nd cause of cancer-related mortality, with transcriptome subtypes related to different prognosis and chemotherapy response.
Comparative Effectiveness of Warfarin and New Oral Anticoagulants for the Management of Atrial Fibrillation and Venous Thromboembolism
Authors: Soheir S. Adam, Jennifer R. McDuffie, Thomas L. Ortel, John W. Williams
Journal: Annals of Internal Medicine (2020)

New oral anticoagulants (NOACs) are emerging alternatives for prophylaxis and treatment of atrial fibrillation (AF) and venous thromboembolism (VTE). This review evaluated the comparative effective...
THE CHANGE FROM GUAIAC TO IMMUNOCHEMICAL FAECAL TEST LEADS TO INCREASED ADENOMA DETECTION RATES IN A REGIONAL COLORECTAL SCREENING PROGRAM
Authors: F Taveira, M Areia, M João, L Elvas, S Alves, D Brito, S Saraiva, AT Cadime
Journal: Endoscopy (2020)

Aims To compare the trends of adenoma and carcinoma detection rates in a regional colorectal screening program after the change from guaiac to faecal immunochemical test (FIT).
NEW INSIGHTS ON THE PROGNOSTIC VALUE OF KRAS MUTATIONAL STATUS EVALUATED ON EUS-GUIDED FINE-NEEDLE ASPIRATION SPECIMENS IN PATIENTS WITH UNRESECTABLE PANCREATIC CANCER
Authors: IM Cazacu, IFC Harbiyeli, BS Singh, A Semaan, MS Serbanescu, A Maitra, MS Bhutani, A Saftoiu
Journal: Endoscopy (2020)

Aims The aim of this study was to investigate the prognostic role of KRAS mutational status within the primary tumor in patients with unresectable locally advanced/metastatic pancreatic ductal adenocarcinoma (PDAC).
Abstract 17237: Physical Inactivity, Mortality and Incident Coronary Heart Disease in Blacks: The Jackson Heart Study
Authors: Daisuke Kamimura, Loretta Cain, Donald T Clark, Cameron S Guild, Paul D Loprinzi, Robert Newton, Takeki Suzuki, John E Hall, Adolfo Correa, Javed Butler, Michael E Hall
Journal: Circulation (2018)

Introduction: Despite reductions in overall mortality in recent decades, blacks continue to have higher death rates compared to whites. According to a recent CDC report, blacks were more likely to have a higher prevalence of unhealthy behaviors such as physical inactivity/sedentariness compared to whites. We assessed the associations between physical activity (PA) and incident coronary heart disease (CHD) and overall mortality in blacks in the Jackson Heart Study (JHS). Methods: Among the 5306 participants enrolled in JHS at baseline (2000-2004), we examined overall mortality through 2016, and among 3507 participants without prevalent CHD at baseline, clinically adjudicated incident CHD events (CHD hospitalizations and fatal myocardial infarction). Based on participant responses and the American Heart Association’s Life’s Simple 7 metrics, participants were classified as having poor (0 minutes/week), intermediate (&amp;rt;0 and &amp;lt;75 minutes/week) or ideal (&amp;lt;=150 minutes/week) PA based on number of minutes of moderate of vigorous PA per week. Cox proportional hazard ratios (HR) were used to assess the relationships between PA categories and incident CHD and overall mortality. Results: Through 2016, there were 992 deaths (18.7% mortality rate) with higher rates in men (21.5%) compared with women (17.1%, p&amp;lt;0.0001). After adjustment for age, sex, education, systolic blood pressure, hypertension medications, diabetes, cholesterol, alcohol use and current smoking at baseline, poor PA was associated with increased mortality (HR 1.53, 95% CI 1.18, 1.98) compared to those with ideal PA. However, there was no significant difference in incident CHD events between those with ideal and poor PA (HR 1.05, 95% CI 0.66, 1.67). Compared with ideal PA, there was no significant difference in mortality in those with intermediate PA (HR 1.23, 95% CI 0.93, 1.62). Conclusions: In a large community-based cohort of blacks, lower PA was associated with higher overall mortality but was not associated with increased risk of incident CHD events.
SUBMUCOSAL TUNNELING ENDOSCOPIC RESECTION (S.T.E.R.) OF A GIANT AND SYMPTOMATIC SUBCARDIAL LEIOMYOMA
Authors: JV Madrigal, JS Montero
Journal: Endoscopy (2020)

Aims S.T.E.R is used as treatment for subepithelial lesions with success rates over 95%. We present a successful resection of a giant, symptomatic, subcardial leiomyoma.
Effect of Recombinant Human Parathyroid Hormone (1-84) on Vertebral Fracture and Bone Mineral Density in Postmenopausal Women with Osteoporosis
Authors: Susan L. Greenspan, Henry G. Bone, Mark P. Ettinger, David A. Hanley, Robert Lindsay, Jose R. Zanchetta, Consuelo M. Blosch, Annette L. Mathisen, Stephen A. Morris, Thomas B. Marriott
Journal: Annals of Internal Medicine (2007)

To determine the safety of parathyroid hormone (PTH) and its effect on the incidence of vertebral fractures in postmenopausal women with osteoporosis, the authors randomly assigned 2532 postmenopau...
Sudden appearance of pruritic eruption with comet sign due to <i>Pyemotes sp</i> .
Authors: M. Albert, A. Finon, L. Machet
Journal: British Journal of Dermatology (2020)

Funding sources: none. Conflicts of interest: The authors declare they have no conflicts of interest. Dear Editor, A 45‐year‐old woman presented with a pruritic rash in June 2019 in rural France. The rash showed multiple erythematous papules with a central vesicle or haemorrhagic punctum, some with a linear erythematous tract, on the neck, trunk and limbs. She reported handling old logs and straw the day before. The comet sign was first described in 2007 as a specific sign of Pyemotes dermatitis induced by Pyemotes ventricosus,1 a mite found in firewood, straw and grain infested by Anobiidae beetles, and for which humans could become accidental prey. The diagnosis is based on the clinical presentation and contact with suspected Pyemotes‐infested material.2
Finding the Balance Between Benefits and Harms When Using Statins for Primary Prevention of Cardiovascular Disease
Authors: Henock G. Yebyo, Hélène E. Aschmann, Milo A. Puhan
Journal: Annals of Internal Medicine (2018)

Most guidelines recommend statins for primary prevention of cardiovascular disease (CVD) if 10-year risk exceeds 7.5% to 10%. However, use of statins for primary prevention of CVD is controversial ...
EXPERIENCE FROM A TERTIARY CENTRE FOR OPTIMAL MANAGEMENT OF PATIENTS REFERRED FOR COMPLEX ENDOSCOPIC PROCEDURES: AN ADVANCED ENDOSCOPY MULTIDISCIPLINARY TEAM MEETING
Authors: A Murino, N Lazaridis, N Koukias, C Coppo, D Costa, A Telese, M Varcada, J Watkins, TV Luong, P Wylie, K Planche, C Hart, A Bailey, R Raymond, EJ Despott
Journal: Endoscopy (2020)

Aims Optimisation of patient care though multidisciplinary team (MDT) meetings is now established as the standard of care in cancer pathways. Cases presented at MDTs are discussed by a panel of experts in order to provide optimal management. An ‘Advanced-endoscopy MDT’ may help to achieve consensus on decision-making, clinical outcomes and patient satisfaction.
TARGETING THE BULLSEYE! ENDOSCOPIC MANAGEMENT OF A COMPLEX POST-SURGICAL AMPULLECTOMY STENOSIS
Authors: P Gkolfakis, H Neuhaus, M Giovannini, J Devière, D Blero
Journal: Endoscopy (2020)

A 60-years-old woman presented 5 episodes of acute pancreatitis a few months after having undergone laparoscopic ampullectomy of a large peri-ampullary adenoma. We demonstrate the endoscopic management of an anastomotic stricture and the effect of secretin administration for spotting the non-visible pancreatico-digestive orifice. During ERCP the orifice was not identified, but soon after secretin injection a punctiform orifice appeared. However, serial cannulation attempts using an ultra-thin sphincterotome and a dilator failed. Pancreatic duct cannulation was only possible with a 6Fr cystotome and pure current application. The stenosis was dilated using a CRE-balloon and a plastic stent was left in place.
First report on screening an asymptomatic population for cancer: The yield of an integrated cancer prevention center.
Authors: Tal Sella, Ben Boursi, Amira Gat-Charlap, Ilan Aroch, Eliezer Liberman, Menachem Moshkowitz, Ehud Miller, Eyal Gur, Arye Blachar, Nicola J. Mabjeesh, Fanny Sperber, Vadim Reiser, Shlomi Kleinman, Ariel J. Jaffa, Mati Ormianer, Inna Naumov, Diana Kazanov, Sarah Kraus, Lior Galazan, Nadir Arber
Journal: Journal of Clinical Oncology (2012)

1564 Background: Cancer is a leading cause of mortality worldwide. Screening is a key strategy for reducing cancer morbidity and mortality. We aimed to evaluate the utility of cancer screening in an asymptomatic population at an integrated cancer prevention center. Methods: One-thousand consecutive asymptomatic, apparently healthy adults, aged 20-80 years, were screened for early detection of 11 common cancers by routine screening tests. Results: Malignant and benign lesions were found in 2.4% and 7.1% of the screenees, respectively. The most common malignant lesions were in the gastrointestinal tract and breast followed by gynecological and skin. The compliance rate for the different screening procedures was considerably higher than the general Israeli population – 78% compared to 60% for mammography (p&lt;0.001) and 39% compared to 16% for colonoscopy (p&lt;0.001). Advanced age, family history and certain lifestyle parameters were associated with increased risk for cancer. Moreover, polymorphisms in the APC and CD24 genes indicated high cancer risk. When two of the polymorphisms existed in an individual, the risk for a neoplastic lesion was extremely high (OR 2.3 [95% CI 0.94-5.9]). Conclusions: A significant number of neoplastic lesions were diagnosed at an early stage. Polymorphisms in the APC and CD24 genes may identify individuals at an increased risk for cancer. Cancer may be diagnosed at an early stage using the screening facilities of a multidisciplinary outpatient clinic.
Primary Care–Based Models for the Treatment of Opioid Use Disorder
Authors: P. Todd Korthuis, Dennis McCarty, Melissa Weimer, Christina Bougatsos, Ian Blazina, Bernadette Zakher, Sara Grusing, Beth Devine, Roger Chou
Journal: Annals of Internal Medicine (2016)

Greater integration of medication-assisted treatment for opioid use disorder in U.S. primary care settings would expand access to treatment for this condition. This article summarizes findings of a...
INTRALESIONAL INJECTION OF ADALIMUMAB IN INTESTINAL STRICTURES OF PATIENTS WITH CROHN’S DISEASE: A RANDOMIZED, MULTICENTER, PROSPECTIVE CLINICAL TRIAL
Authors: B González-Suárez, A Giordano, C Romero, S Khorrami, A Gutierrez, MD Martín Arranz, L Argüello, L Marquez, CH Nadal, A Echarri, YG Lama, J Panés, E Ricart
Journal: Endoscopy (2020)

Aims Intestinal strictures in patients with Crohn’s disease (CD) represent a challenge due to their low response rate to medical therapy and high recurrence after endoscopic or surgical treatment. The intralesional injection of anti-TNF drugs is an option not fully investigated.
‘Rinse and Replace’: Boosting T Cell Turnover To Reduce HIV-1 Reservoirs
Authors: Zvi Grossman, Nevil J. Singh, Francesco R. Simonetti, Michael M. Lederman, Daniel C. Douek, Steven G. Deeks, Takeshi Kawabe, Gennady Bocharov, Martin Meier-Schellersheim, Hagit Alon, Nicolas Chomont, Zehava Grossman, Ana E Sousa, Leonid Margolis, Frank Maldarelli
Journal: Trends in Immunology (2020)
IMPROVING STANDARDS OF UPPER ENDOSCOPY FOR BARRETT’S OESOPHAGUS BY IMPLEMENTING KEY PERFORMANCE MEASURES - A QUALITY IMPROVEMENT INITIATIVE
Authors: D Subhaharan, S John
Journal: Endoscopy (2020)

Aims Quality metrics for Barrett’s oesophagus are lacking in comparison to colonoscopy. They may be equally important in detection of neoplasia and improving clinical outcome. The ESGE has published key performance measures in Barrett’s assessment. Our study aimed to assess the impact of implementing performance measures in improving quality of endoscopy in Barrett’s oesophagus.
The Covid-19 Pandemic and the Incidence of Acute Myocardial Infarction
Authors: Matthew D. Solomon, Edward J. McNulty, Jamal S. Rana, Thomas K. Leong, Catherine Lee, Sue-Hee Sung, Andrew P. Ambrosy, Stephen Sidney, Alan S. Go
Journal: New England Journal of Medicine (2020)

Acute Myocardial Infarction and Covid-19 Data from the Kaiser Permanente Northern California health care system were used to compare rates of hospitalization for acute MI from March 4 through April...
Should Extremely Premature Babies Get Ventilators During the COVID-19 Crisis?
Authors: Marlyse F. Haward, Annie Janvier, Gregory P. Moore, Naomi Laventhal, Jessica T. Fry, John Lantos
Journal: The American Journal of Bioethics (2020)

In a crisis, societal needs take precedence over a patient's best interests. Triage guidelines, however, differ on whether limited resources should focus on maximizing lives or life-years. Choosing between these two approaches has implications for neonatology. Neonatal units have ventilators, some adaptable for adults. This raises the question of whether, in crisis conditions, guidelines for treating extremely premature babies should be altered to free-up ventilators. Some adults who need ventilators will have a survival rate higher than some extremely premature babies. But surviving babies will likely live longer, maximizing life-years. Empiric evidence demonstrates that these babies can derive significant survival benefits from ventilation when compared to adults. When "triaging" or choosing between patients, justice demands fair guidelines. Premature babies do not deserve special consideration; they deserve equal consideration. Solidarity is crucial but must consider needs specific to patient populations and avoid biases against people with disabilities and extremely premature babies.
COMPARISON OF THE PRECISION OF OPTICAL DIFFERENTATION BETWEEN NEOPLASTIC AND NON-NEOPLASTIC SUBCENTRIMETRIC POLYP HISTOLOGY BY ENDOSCOPIC EXPERTS AND ARTEFICIAL INTELLIGENCE DEEP LEARNING NEURAL NETWORK (POLYPBRAIN)
Authors: L Madácsy, M Szalai, Á Finta, K Zsobrák, L Oczella, I Hritz, BD Lovász, Z Dubravcsik
Journal: Endoscopy (2020)

Aims Background Precise differentiation between sub-centimetric neoplastic and non-neoplastic polyps is important. New polyp classification systems such as BASIC classification and artificial intelligence deep learning algorithm-based Decision Support System (AI-DSS) are developed to achieve high accuracy necessitated by application of the resect-and-discard strategy in everyday practice for non-expert endoscopists.
The Clinical Benefit of Event-Free Survival (EFS) in Acute Myeloid Leukemia (AML): A Surrogate of Overall Survival (OS) or Meritorious on Its Own Right?
Authors: Abhishek Maiti, Hagop M. Kantarjian, Vinita Popat, Guillermo Garcia-Manero, Marina Konopleva, Srdan Verstovsek, Michael Andreeff, Gautam Borthakur, Tapan Kadia, Naval Daver, Naveen Pemmaraju, Courtney D. DiNardo, Sherry Pierce, William G Wierda, Steven Kornblau, Farhad Ravandi, Jorge E. Cortes
Journal: Blood (2017)