FRI0500 Extracranial vascular affection in giant cell arteritis
Authors: J.L. Martín-Varillas, J. Loricera, D. Prieto-Peña, J. Narváez, E. Aurrecoechea, I. Villa, S. Castañeda, C. Gómez-Arango, A. Mera, E. Pérez-Pampín, V. Aldasoro, N. Álvarez-Rivas, N. Fernández-Llanio, M. Álvarez de Buergo, L. Marena-Rojas, F. Sivera, E. Galíndez-Aguirregoikoa, R. Solans-Laqué, S. Romero-Yuste, N. Ortego, M. Revenga, C. Larena, Í. Hernández, F.J. Maceiras-Pan, E. Salgado, S. Fernández, M. Calderón-Goercke, I. Martínez-Rodríguez, J.I. Banzo, V. Calvo-Río, B. Atienza-Mateo, N. Palmou-Fontana, C. González-Vela, J.L. Hernández, M.A. González-Gay, R. Blanco
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Giant cell arteritis (GCA) is a large vessel vasculitis with a predisposition for the cranial branches of the external carotid artery. However, aorta and/or its main branches may also be involved <b>(<sup>1–3</sup></b>. <h3>Objectives</h3> To assess the vascular territories most frequently affected in a series of patients with GCA who presented extracranial vessel involvement. <h3>Methods</h3> Retrospective study of patients with GCA who presented compromise of extracranial vessels confirmed by PET/CT. Visual analysis of vascular uptake was performed on supra-aortic trunks (SAT), aortic arch (AA), thoracic aorta (TA), abdominal aorta (AA), iliac arteries (IA), lower limb arteries (LLA), and upper limb arteries (ULA). We carried out a comparative study between both sexes to see if there was any difference in the pattern of affectation. <h3>Results</h3> We evaluated 68 patients with GCA (51W/17M) with a mean age of 68.06±8.33 years. The vascular territories affected were: TA (n=58, 85.29%), SAT (n=38, 55.88%), AA (n=28, 41.18%), AA (n=18, 26.47%), LLA (n=17, 25%), IA (n=13, 19.12%) and ULA (n=6, 8.82%). We also made a study of the number of vascular territories affected: 1 vascular territory (n=13, 19.12%), 2 territories (n=22, 32.35%), 3 territories (n=18, 26.47%), 4 territories (n=12, 17.65%) and more than 4 territories (n=3, 4.41%). Likewise, a comparative study between both sexes was conducted, in which only statistical significance was achieved in the involvement of ULA, which was more frequent in men (table 1). <h3>Conclusions</h3> In patients with GCA the involvement of TA is very frequent, followed by the SAT and the AA. To a lesser extent, the AA and the LLA vessels are affected. The involvement of the IA and the ULA vessels is less frequent; the latter more frequently in men. On the other hand, the involvement of 2–3 vascular territories are the most frequent patterns. <h3>References</h3> [1] Loricera J, Blanco R, Hernández JL, et al. Use of positron emission tomography (PET) for the diagnosis of large-vessel vasculitis. Rev Esp Med Nucl Imagen Mol. 2015;34:372–377. [2] Loricera J, Blanco R, Hernández JL, et al. Non-infectious aortitis: a report of 32 cases from a single tertiary centre in a 4-year period and literature review. Clin Exp Rheumatol. 2015;33:S19–31. [3] Loricera J, Blanco R, Hernández JL, et al. Tocilizumab in giant cella arteritis: Multicenter open-label study of 22 patients. Semin Arthritis Rheum. 2015;44:717–723. <h3>Disclosure of Interest</h3> None declared