Do Neuroleptics Still Have a Role in Patients With Delirium?
Authors: Roozbeh Nikooie, Esther S. Oh, Allen Zhang, Karen A. Robinson, Dale M. Needham
Journal: Annals of Internal Medicine (2020)

Letters18 February 2020Do Neuroleptics Still Have a Role in Patients With Delirium?Roozbeh Nikooie, MD, Esther S. Oh, MD, PhD, Allen Zhang, BS, Karen A. Robinson, PhD, and Dale M. Needham, MD, PhDRoozbeh Nikooie, MDJohns Hopkins University School of Medicine, Baltimore, Maryland (R.N., E.S.O., K.A.R., D.M.N.)Search for more papers by this author, Esther S. Oh, MD, PhDJohns Hopkins University School of Medicine, Baltimore, Maryland (R.N., E.S.O., K.A.R., D.M.N.)Search for more papers by this author, Allen Zhang, BSJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland (A.Z.)Search for more papers by this author, Karen A. Robinson, PhDJohns Hopkins University School of Medicine, Baltimore, Maryland (R.N., E.S.O., K.A.R., D.M.N.)Search for more papers by this author, and Dale M. Needham, MD, PhDJohns Hopkins University School of Medicine, Baltimore, Maryland (R.N., E.S.O., K.A.R., D.M.N.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L19-0703 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate Dr. Grouls and colleagues' interest in our paper and are pleased to provide clarification for their 3 comments.Regarding the first comment, in the Discussion section, we reported the following relevant text:Moreover, the included studies did not rigorously evaluate the effect of antipsychotics on patient distress…. Hence, additional large, rigorous studies are needed, including greater focus on these outcomes (1).With respect to the second comment, due to limitations in space, we could not separately report each of the a priori subgroup analyses. We refer readers to the full evidence report (https://effectivehealthcare.ahrq.gov/sites/default/files/pdf/delirium-finalreport.pdf) (2) for these ...References1. Nikooie R, Neufeld KJ, Oh ES, et al. Antipsychotics for treating delirium in hospitalized adults: a systematic review. Ann Intern Med. 2019;171:485-95. [PMID: 31476770]. doi:10.7326/M19-1860 LinkGoogle Scholar2. Neufeld KJ, Needham DM, Oh ES, et al. Antipsychotics for the Prevention and Treatment of Delirium. Comparative Effectiveness Review No. 219. (Prepared by the Johns Hopkins University Evidence-based Practice Center under contract 290-2015-00006-I-2.) AHRQ Publication no. 19-EHC019-EF. Rockville, MD: Agency for Healthcare Research and Quality; September 2019. doi:10.23970/AHRQEPCCER219 CrossrefGoogle Scholar3. Hu H, Deng W, Yang H, et al. Olanzapine and haloperidol for senile delirium: a randomized controlled observation. Chinese Journal of Clinical Rehabilitation. 2006;10:188-90. Google Scholar4. Rose L, Agar M, Burry LD, et al; Del-COrS group. Development of core outcome sets for effectiveness trials of interventions to prevent and/or treat delirium (Del-COrS): study protocol. BMJ Open. 2017;7:e016371. [PMID: 28928181] doi:10.1136/bmjopen-2017-016371 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Johns Hopkins University School of Medicine, Baltimore, Maryland (R.N., E.S.O., K.A.R., D.M.N.)Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland (A.Z.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M19-1860. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAntipsychotics for Treating Delirium in Hospitalized Adults Roozbeh Nikooie , Karin J. Neufeld , Esther S. Oh , Lisa M. Wilson , Allen Zhang , Karen A. Robinson , and Dale M. Needham Do Neuroleptics Still Have a Role in Patients With Delirium? Astrid Grouls , Eduardo Bruera , and David Hui Metrics 18 February 2020Volume 172, Issue 4Page: 295-296KeywordsAntipsychoticsDeliriumDisclosureDrug regulationDrugsObservational studiesPatientsPopulation statisticsSedationSystematic reviews ePublished: 18 February 2020 Issue Published: 18 February 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...