AB0583 Neoplasia prevalence in primary sjÖgren’s syndrome in hispanic patients
Authors: J.C. Riega-Torres, J. Hermosillo-Villafranca, G. Hernandez-Molina, R. Barbosa-Cobos, C. Skinner-Taylor, M. Garza-Elizondo, A. Garcia-Garcia, E. Flores-Huerta
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> A rheumatic disease may be a casual factor in the pathogenesis of a neoplastic disease, as in other cases, cancer may lead to the development of paraneoplastic rheumatic manifestations that may be the only initial symptoms<sup>1</sup>. Lazarus <i>et al</i>. demonstrated in its cohort study with 112 patients that of the 22% of patients who developed some neoplasm during the study, the most prevalent was lymphoma with 44%. according to the same study, patients with pss present a risk 37.5 times more than that of the general population. of generating lymphoma, with another risk 2.6 times of developing another type of cancer<sup>2</sup>.it was also shown that in patients with pss there is an incidence of 320 cases per 100 000 a year of presenting non-hodgkin's lymphoma<sup>3</sup>. In our country there are no epidemiological studies to know the prevalence of cancer in patients with pss, so these numbers are difficult to estimate <h3>Objectives</h3> Determine the prevalence of cancer in patients with ss in the mexican population. <h3>Methods</h3> Cross-sectional, observational study was conducted in which 393 patients were included, of which 221 (52%) came from the national institute of medical sciences and nutrition "salvador zubiran", 92 (23.4%) from the university hospital "José E González" and 80 (20.6%) of the juárez mexico hospital/ABC medical centre whom fulfilled the diagnosis of ssp according to the 2002/2012 criteria of the american college of rheumatology/european league against rheumatism. Bivariate anailsis was performed, normality was demonstrated using the K.S test, the student's T test was used for the numerical variables and the chi2 test for the categorical ones, and no difference was found between the characteristics of patients with or without cancer. <h3>Results</h3> We include 393 patients, the majority were women (n=377, 95.9%) with an average age of 56.4 (±13.60), of these 23 (5.85%) had some type of neoplasm regardless of their malignancy. the most prevalent was lymphoma with 9 cases (34.6%), followed by breast cancer with 5 (19.2%), 3 (11.5%) of basal cell cancer and 2 (7.7%) cases of cervical uterine cancer <h3>Conclusions</h3> We confirmed lymphoma as the most prevalent neoplasia in a cohort of non-Caucasian pSS patients. We observed the presence of non-hematologicalmalignancy 60.86% of our patients, whether it risk is increased in pSS population still needs to be addressed. <h3>References</h3> [1] Bellan M, Boggio E, Sola D, Gibbin A, Gualerzi A, Favretto S, … Sainaghi PP. Association between rheumatic diseases and cancer: results from a clinical practice cohort study. Internal and Emergency Medicine2017;12(5):621–627. [2] Lazarus MN. Incidence of cancer in a cohort of patients with primary Sjogren's syndrome. Rheumatology2006;45(8):1012–1015. [3] Nishishinya MB, Pereda CA, Muñoz-Fernández S, Pego-Reigosa JM, Rúa-Figueroa I, Andreu JL, … Santamaría EL. Identification of lymphoma predictors in patients with primary Sjögren's syndrome: A systematic literature review and meta-analysis. Rheumatology International2015;35(1):17–26. <h3>Disclosure of Interest</h3> None declared