tbuckley/cabot-search huggingface dataset:
Abstract 15653: Optimizing the Screening Algorithm for Critical Congenital Heart Disease: A Data-Driven Approach
Authors: Matthew Oster, Caglar Caglayan, Regina Simeone, Pinar Keskinocak, Turgay Ayer
Journal: Circulation (2015)

Introduction: Screening for critical congenital heart disease (CCHD) using pulse oximetry is performed with various algorithms in the United States, with none of these based on robust data, including the one endorsed by the AHA and other organizations. Hypothesis: Existing algorithms will have differing results for CCHD screening, and the test characteristics of these algorithms can be improved through modifications. Methods: After collecting de-identified, patient-level pulse oximetry values from existing national and international screening programs, we compared the commonly used algorithms in the US: the American Academy of Pediatrics (AAP) algorithm (endorsed by the AHA), the New Jersey (NJ) algorithm (slight modification of the AAP algorithm), and the Tennessee (TN) algorithm (screening first on the foot only). We then considered alternate algorithms by modifying the pulse oximetry values that would be considered a pass, fail, or retest result in the existing algorithms. We compared the algorithms according to sensitivity (Se), false positive rate (FP), and area under the curve (AUC). Results: There were 75,748 screenings, with 57 true positives. Performance characteristics of the 3 common algorithms are summarized in the Table. The NJ algorithm had the greatest Se but also the highest FP, and the TN algorithm had the lowest Se but also the lowest FP. Modifications of these algorithms yielded 2632 potential algorithms with Se ranging from 28% to 91%, FP from 0.05% to 60%, and AUC from 0.64 to 0.82. Of these, 224 algorithms met our optimal algorithm criteria of Se &gt;50%, FP 0.75. Conclusions: Current algorithms for CCHD screening vary in their test performance characteristics, and there are opportunities to modify these algorithms to improve test performance. Before identifying an optimal algorithm, further work is needed to collect more data (including more robust data on false negatives) and to compare the cost and ease of use of potential algorithms.
HALF NORMAL SALINE SHORTENS THE TIME TO ACHIEVE BIDIRECTIONAL BLOCK IN TYPICAL ATRIAL FLUTTER
Authors: Kathryn L. Hong, David Bakker, Jason Baley, Corinne Babiolakis, Milena Bullen, Chao Xue, Filipa Saramago, Damian Redfearn, Benedict Glover
Journal: Journal of the American College of Cardiology (2019)
Abstract 108: Molecular and Electrophysiologic Characterization of Obesity Mediated Atrial Fibrillation in <i>Mc4r-KO</i> Mice
Authors: Ambili Menon, Mark McCauley, Liang Hong, Arvind Sridhar, Srikanth Perike, Meihong Zhang, Erin Lambers, Dawood Darbar
Journal: Circulation Research (2018)

Background: Although a causal relationship between obesity and atrial fibrillation (AF) has recently been established, the underlying pathophysiological mechanisms remain unclear. Emerging evidence supports reduced cardiac Na + channel expression and current (I Na ) as one potential contributing mechanism. Mutations in the melanocortin-4 receptor ( MC4R ) gene are the most common monogenic form of obesity in humans. Objective: We used a genetic Mc4r-knockout, KO mouse model of obesity to test the hypothesis that obesity increases susceptibility to AF by modulating the cardiac Na + channel. Method: Invasive electrophysiology studies and patch clamping of membrane potentials were performed in mice between 4-6 months of age to evaluate the molecular and whole-animal electrophysiologic phenotype. Results: Mc4r-KO mice were significantly heavier than wild-type lean controls. Pacing induced AF in 100% of Mc4r-KO mice, and 25% in controls; AF burden was more in Mc4r-KO mice than control mice. We showed that the expression of the cardiac Na + channel, I Na , and atrial action potential duration was reduced in Mc4r-KO mice. Furthermore, the oxidative stress biomarker F2-isoprostanes levels were elevated in MC4r-KO when compared to controls and these levels along with AF burden were reduced after 2 weeks of mitochondrial antioxidant (Mito-TEMPO) administration. Conclusion: We showed that mice with genetic susceptibility to obesity are not only more prone to develop AF but that this risk is mediated in part by modulation of the cardiac Na + channel and increased oxidative stress. These findings may have important implications for the management of obesity-mediated AF in humans.
POSSIBLE MECHANISM OF LATE SYSTOLIC MITRAL VALVE PROLAPSE: SYSTOLIC SUPERIOR SHIFT OF LEAFLETS SECONDARY TO ANNULAR DILATATION THAT TRACTS PAPILLARY MUSCLE
Authors: Soshi Hei, Mai Iwataki, Takeshi Onoue, Yasufumi Nagata, Yutaka Otsuji
Journal: Journal of the American College of Cardiology (2019)
SUCCESSFUL PERCUTANEOUS RETRIEVAL OF AN ATRIAL SEPTAL OCCLUDER DEVICE MIGRATED TO THE RIGHT VENTRICULAR OUTFLOW TRACT
Authors: Luis Olmos Dominguez, Jorge Emilio Carrillo Guevara, Alberto Carlos Heredia Salazar, Joaquin Gomez Leon, Gustavo Moreno Castillo, Pedro Davila Flores, Jesus Bueno Campa, Adrian Alan Guzman de Leon
Journal: Journal of the American College of Cardiology (2019)
ASSOCIATION OF DURATION FOR RENAL REPLACEMENT THERAPY OR SERUM PHOSPHORUS LEVEL WITH THE PROGNOSIS OF CRITICAL LIMB ISCHEMIA AFTER ENDOVASCULAR THERAPY
Authors: Naoko Higashino, Osamu Iida, Mitsutoshi Asai, Masaharu Masuda, Shin Okamoto, Takayuki Ishihara, Kiyonori Nanto, Takashi Kanda, Takuya Tsujimura, Shota Okuno, Yasuhiro Matsuda, Hiroyuki Kawai, Yosuke Hata, Aki Tsuji, Yuki Sato, Hiroyuki Uematsu, Taku Toyoshima, Toshiaki Mano
Journal: Journal of the American College of Cardiology (2019)
Endoscopic gastroplasty as therapy for postoperative gastric distortion and stenosis
Authors: Bing-Rong Liu, Dan Liu, Li-Xia Zhao, Saif Ullah, Yang-Yang Zhou, Ji-Yu Zhang, Kong Ling-Jian
Journal: Endoscopy (2019)

Gastric stricture resulting in impairment of gastric emptying may occur after gastric surgery or laparoscopic surgery [1] [2] [3]. In some instances further surgery can be avoided by endoscopic balloon dilation of the stricture [4] [5]. We present an unusual case of gastric distortion and stricture after resection of a gastrointestinal stromal tumor (GIST). Because balloon dilation failed to effectively relieve the obstruction, endoscopic gastroplasty was performed with good success.
NATIONAL TRENDS OF ACUTE PERICARDITIS AND PERICARDIAL EFFUSION POST ATRIAL FIBRILLATION ABLATION
Authors: Fahed Darmoch, Yasser Al-Khadra, Mohamad Soud, Homam Moussa Pacha, Amir Kaki, M. Chadi Alraies, Allan Klein
Journal: Journal of the American College of Cardiology (2019)
What Is a Pandemic?
Authors: Dara Grennan
Journal: JAMA (2019)

What Is a Pandemic?The terms endemic, outbreak, epidemic, and pandemic indicate how common a condition is at a point in time relative to how common it was at an earlier time.The terms endemic, outbreak, epidemic, and pandemic are often used to describe infections, although conditions such as hypertension, cancer, violence, or even positive, beneficial behaviors can also be described the same way.These categories are primarily based on how many cases of a condition there are compared with the expected number of cases over a given time and how far the cases have spread geographically.
TEMPORAL TRENDS IN STENT COVERAGE OF BIORESORBABLE POLYMER AND DURABLE POLYMER DRUG-ELUTING STENTS: A META-ANALYSIS OF STRUT-LEVEL OPTICAL COHERENCE TOMOGRAPHY DATA
Authors: Stefan Koester, Justin Lee, Chun-Yu Lee, Chiu-Hsieh Hsu, Bishnu Dhakal, Huy Dinh, Asri Ranga, Kwan Lee
Journal: Journal of the American College of Cardiology (2019)
SUBCLINICAL ORGAN DAMAGE IMPROVES ATHEROSCLEROTIC CARDIOVASCULAR RISK ASSESSMENT ABOVE 10-YEAR CHINA-PAR (PREDICTION FOR ASCVD RISK IN CHINA) EQUATIONS: RESULTS FROM THE POPULATION-BASED RURAL STUDY
Authors: Haoyu Wang, Yingxian Sun, Wenrui Shi, Shuze Wang, Xin Yi
Journal: Journal of the American College of Cardiology (2019)
TWO NEW MORPHOLOGICAL RV HYPERTROPHIC PATTERNS IN PULMONARY HYPERTENSION ON CARDIAC CT: RV OUTFLOW TRACT DOMINANT AND DIFFUSE TYPE: INFLUENCE OF THESE FACTORS ON SEVERITY AND PROGNOSIS OF PULMONARY HYPERTENSION
Authors: Nobusada Funabashi, Gentaro Koyama, Yoshio Kobayashi
Journal: Journal of the American College of Cardiology (2019)
THE PREDICTIVE VALUE OF THE HEART SCORE TOOL USING HIGH-SENSITIVITY TROPONIN T: COMPARISON TO CURRENT GENERATION TROPONIN T IN A UNITED STATES ACUTE CHEST PAIN POPULATION
Authors: Karanvir S. Grewal, Galen Hayek, Deep Shah, Shray Jain, Nathan Nahhas, Tamara McMath, Anand Gupta
Journal: Journal of the American College of Cardiology (2019)
SUBMASSIVE PULMONARY EMBOLISM: ARE WE FALSELY REASSURED BY NORMOTENSION?
Authors: Kateria Porcaro, Jeremiah Haines, Stephen Morris, Demetrios Doukas, Erin Mancl, Dalila Masic, Estefania Oliveros, Vladimir Lakhter, Carlos Bechara, John J. Lopez, Verghese Mathew, Yevgeniy Brailovsky, Jawed Fareed, Amir Darki
Journal: Journal of the American College of Cardiology (2019)
THE NOVEL ADIPOKINE C1QTNF1 SIGNIFICANTLY PREDICTS THE INCIDENCE OF FUTURE MAJOR CARDIOVASCULAR EVENTS IN PATIENTS WITH TYPE 2 DIABETES
Authors: Axel Muendlein, Andreas Leiherer, Christoph H. Saely, Kathrin Geiger, Eva-Maria Brandtner, Barbara Larcher, Arthur Mader, Peter Fraunberger, Heinz Drexel
Journal: Journal of the American College of Cardiology (2019)
CRISPR-Based Dual-Knockout Screens Reveals Network of Interactions between Key Dependencies for Myeloma Cells and Highlights IRF4 As a Central Regulator of Myeloma Cell Behavior
Authors: Sondra L. Downey-Kopyscinski, Ricardo De Matos Simoes, Ryosuke Shirasaki, Olga Dashevsky, Brian Glassner, Olivia Bare, John G Doench, Constantine S. Mitsiades
Journal: Blood (2018)
PARADOXICAL PROTECTIVE EFFECT OF OBESITY ON THE RISK OF VENOUS THROMBOEMBOLISM: OBSERVATIONS FROM APEX TRIAL
Authors: Arzu Kalayci Karabay, C. Michael Gibson, Gerald Chi, Fahad Alkhalfan, Anmol Pitliya, Sargun Singh Walia, Tarek Nafee, Mahshid Mir, Syed Hassan Abbas Kazmi, Iqra Qamar, Adrian Hernandez, Russell Hull, Alexander (Ander) Cohen, Robert Harrington, Samuel Goldhaber
Journal: Journal of the American College of Cardiology (2019)
EMBOLIC STROKE IN A PATIENT WITH EVANS SYNDROME RECEIVING RITUXIMAB THERAPY
Authors: Gaurav Patel, Prasanthi Limgala, Purveshkumar Patel, Michael Makar, Jumee Barooah, Muhammad Siddique Pir, Najam Us Saqib, Madhava Rao, Pranjal Boruah
Journal: Journal of the American College of Cardiology (2019)
COMPARISON OF PERCUTANEOUS CORONARY INTERVENTION VERSUS CORONARY ARTERY BYPASS GRAFTING IN OLDER ADULTS WITH UNPROTECTED LEFT MAIN CORONARY ARTERY DISEASE: A META-ANALYSIS AND METAREGRESSION
Authors: Mahin R. Khan, Waleed T. Kayani, Waqas Ahmad, Sadar Siddiqui, Saima A. Shahzad, Shazhad A. Mumtaz, Malalai Manan, Ravi S. Hira, Ihab Hamzeh, Hani Jneid, Salim S. Virani, Neal Kleiman, Mahboob Alam
Journal: Journal of the American College of Cardiology (2019)
Signatures of Histone Modification Marks and Proteins in Pediatric Acute Myeloid Leukemia: A Comparison to Adults
Authors: Anneke D. Van Dijk, Fieke W Hoff, Eveline S. de Bont, YIHUA QIU, Chenyue W. Hu, Amina A Qutub, Terzah M. Horton, Steven M. Kornblau
Journal: Blood (2018)
Abstract 278: Dual Modulation of Microscale Tissue Engineering and Energy Metabolism for Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes
Authors: Cinsley Gentillon, Meixue Duan, Wen-Mei Yu, Rajneesh Jha, Shuzhao Li, Bill Liang, Andrei Todor, Greg Gibson, Cheng-Kui Qu, Lou Ann Brown, Chunhui Xu
Journal: Circulation Research (2018)

Background: Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) represent a viable cell source for clinical application and other purposes, such as disease modeling and drug discovery for cardiovascular diseases. However, their immature phenotype limits their utility for these applications. It is widely known that the transition from fetal to adult heart during development is accompanied by an alteration in energy metabolism from glycolysis to fatty acid oxidation (FAO), respectively. Using this metabolic hallmark of cardiomyocyte maturation, we investigated a platform that combines three-dimensional (3D) cell cultivation and molecules that target key pathways involved in the energy metabolism of cardiomyocytes. Methods: Cardiac spheres of highly-enriched hPSC-CMs were generated from cardiac-differentiated cultures and treated with a combination of five molecules or control (DMSO) for one week. We used functional, morphological, transcriptome and metabolome analyses to assess the maturation status of hPSC-CMs. RESULTS: Treatment of 3D hPSC-CMs with a combination of five molecules elicited increased FAO along with mitochondrial respiratory capacity. These changes in oxidative capacity were associated with increased mitochondrial content and DNA. In addition, cardiac spheres treated with combined molecules displayed enhanced calcium transient kinetics when compared to control cells. RNA sequencing revealed upregulation of genes involved in many cellular metabolic processes, including FAO. Lastly, metabolic profiling of these cardiac spheres identified more than one hundred metabolites that were altered upon treatment. Conclusions: Our study showed that microscale tissue engineering along with treatment of hPSC-CMs with a combination of five molecules increase mitochondrial function, alter molecular and metabolic profiles, and potentially improve cardiomyocyte maturation.
TRANSFERRIN RECEPTOR 1 HETEROZYGOUS DELETED MICE DID NOT AFFECT BLOOD PRESSURE IN THE DEVELOPMENT OF DIABETIC MELLITUS
Authors: Seiki Yasumura, Yoshiro Naito, Keisuke Okuno, Yuki Matsumoto, Masanori Asakura, Masaharu Ishihara
Journal: Journal of the American College of Cardiology (2019)
POLYGENIC HYPERLIPIDEMIAS AND CORONARY ARTERY DISEASE RISK
Authors: Pietari Ripatti, Sanni Soderlund, Joel T. Ramo, Ida Surakka, Aki S. Havulinna, Elisabeth Widen, Priit Palta, Nelson B. Freimer, Veikko Salomaa, Matti Pirinen, Aarno Palotie, Marja-Riitta Taskinen, Samuli Ripatti
Journal: Journal of the American College of Cardiology (2019)
MACHINE LEARNING PREDICTION OF ECHOCARDIOGRAPHIC RESPONSE AND SURVIVAL IN CARDIAC RESYNCHRONIZATION THERAPY
Authors: Albert Feeny, John Rickard, Divyang Patel, Saleem Toro, Kevin Trulock, Carolyn Park, Niraj Varma, Mark Niebauer, Sunil Sinha, David Spragg, Mina Chung
Journal: Journal of the American College of Cardiology (2019)
COMPARISON OF SHORT-TERM OUTCOMES AFTER SUPERIOR CAVOPULMONARY CONNECTION WITH AND WITHOUT ELIMINATION OF ANTEGRADE PULMONARY BLOOD FLOW
Authors: Thomas Dietzman, John Depaolo, Stefania Soria, Matthew Gillespie, Christopher Mascio, Yoav Dori, Michael O'Byrne, Jonathan Rome, Andrew Glatz
Journal: Journal of the American College of Cardiology (2019)
20(S)-Protopanaxatriol Promotes Fatty Acid-Induced ER Stress and Apoptosis in Multiple Myeloma By Down-Regulating SCD1 Expression
Authors: Qiuguo Wang, Siqi Yan, Xiaoran Zhou, Huiling Mei, Yu Xiang, Bin Fang, Leilei Zhang, Yu Hu, Qiuguo Wang
Journal: Blood (2018)
HEART TEAM STRUCTURED TO MAXIMIZE TRANSCATHETER AORTIC VALVE REPLACEMENT OUTCOMES: FIRST 200 IMPLANTS WITH ZERO 30-DAY MORTALITY IN 220 BED HOSPITAL
Authors: Peter Auteri, Joseph S. Auteri, Steven Guidera, Frank Grzywacz, David Boland, Richard Mascolo, Craig Kesack, Jennifer Harrar, James McClurken
Journal: Journal of the American College of Cardiology (2019)
SAPHENOUS VEIN GRAFT ANEURYSM RESULTING IN EXTRINSIC PULMONARY ARTERY COMPRESSION AND RIGHT HEART FAILURE REQUIRING RIGHT VENTRICULAR IMPELLA SUPPORT
Authors: Preethi Mani, Amar Krishnaswamy, Shinya Unai, Jennifer Hargrave, Paul Cremer
Journal: Journal of the American College of Cardiology (2019)
IDENTIFYING SOCIOECONOMIC AND GEOGRAPHIC BARRIERS TO PRENATAL DETECTION OF HYPOPLASTIC LEFT HEART SYNDROME AND TRANSPOSITION OF THE GREAT ARTERIES
Authors: Anita N. Krishnan, Marni Jacobs, Aarti Bhat, Anjali Chelliah, Joanne Chiu, Bettina Cuneo, Grace Freire, Lisa Hornberger, Lisa Howley, Nazia Husain, Catherine Ikemba, Ann Kavanaugh-McHugh, Shelby Kutty, Caroline Lee, Keila Lopez, Erik Michelfelder, Shaine Morris, Shabnam Peyvandi, Nelangi Pinto, Rachel Schwartz, Kenan Stern, Carolyn Taylor, Varsha Thakur, Carol Wittlieb-Weber, Mary Donofrio
Journal: Journal of the American College of Cardiology (2019)
BENEFIT OF AORTIC VALVE REPLACEMENT IN AORTIC STENOSIS WITH VERY LOW LEFT VENTRICULAR EJECTION FRACTION
Authors: Mohamed-Salah Annabi, Abdellaziz Dahou, Ian Burwash, Philipp Bartko, Jutta Bergler-Klein, Ezequiel Guzzetti, Stefan Orwat, Helmut Baumgartner, Julia Mascherbauer, Gerald Mundigler, Joao L. Cavalcante, Josep Rodes-Cabau, Marie-Annick Clavel, Philippe Pibarot
Journal: Journal of the American College of Cardiology (2019)
Surufatinib in Advanced Well-Differentiated Neuroendocrine Tumors: A Multicenter, Single-Arm, Open-Label, Phase Ib/II Trial
Authors: Jianming Xu, Jie Li, Chunmei Bai, Nong Xu, Zhiwei Zhou, Zhiping Li, Caicun Zhou, Ru Jia, Ming Lu, Yuejuan Cheng, Chenyu Mao, Wei Wang, Ke Cheng, Chunxia Su, Ye Hua, Chuan Qi, Jing Li, Wei Wang, Ke Li, Qiaoling Sun, Yongxin Ren, Weiguo Su
Journal: Clinical Cancer Research (2019)

No antiangiogenic treatment is yet approved for extrapancreatic neuroendocrine tumors (NET). Surufatinib (HMPL-012, previously named sulfatinib) is a small-molecule inhibitor targeting vascular endothelial growth factor receptors, fibroblast growth factor receptor 1 and colony-stimulating factor 1 receptor. We conducted a single-arm phase Ib/II study of surufatinib in advanced NETs.Patients with histologically well-differentiated, low or intermittent grade, inoperable or metastatic NETs were enrolled into a pancreatic or extrapancreatic NET cohort. Patients were treated with surufatinib 300 mg orally, once daily. The primary endpoints were safety and objective response rate (ORR) according to Response Evaluation Criteria in Solid Tumors (version 1.1).Of the 81 patients enrolled, 42 had pancreatic NETs and 39 had extrapancreatic NETs. Most patients had radiologic progression within 1 year prior to enrollment (32 patients in each cohort). In the pancreatic and extrapancreatic NET cohorts, ORRs were 19% [95% confidence intervals (CI), 9-34] and 15% (95% CI, 6-31), disease control rates were 91% (95% CI, 77-97) and 92% (95% CI, 79-98), and median progression-free survival was 21.2 months (95% CI, 15.9-24.8) and 13.4 months (95% CI, 7.6-19.3), respectively. The most common grade ≥3 treatment-related adverse events were hypertension (33%), proteinuria (12%), hyperuricemia (10%), hypertriglyceridemia, and diarrhea (6% for each), and increased alanine aminotransferase (5%).Surufatinib showed encouraging antitumor activity and manageable toxicities in patients with advanced NETs. Two ongoing phase III studies, validating the efficacy of surufatinib in patients with NETs, will contribute to the clinical evidence.
Abstract 20383: Incidence, Predictors, and Impact of Bioprosthetic Valve Hemodynamic Deterioration Following Aortic Valve Replacement
Authors: Erwan Salaun, Haïfa Mahjoub, Nicolas Girerd, Francois Dagenais, Pierre Voisine, Siamak Mohammadi, Dimitris Kalavrouziotis, Bobby Yanagawa, Subodh Verma, Marie-Annick Clavel, Philippe Pibarot
Journal: Circulation (2017)

Introduction: The incidence of structural valve deterioration (SVD) after aortic valve replacement (AVR) is generally established on the basis of reoperation due to valve failure. This approach may significantly underestimate the incidence of SVD. Objectives: to determine the incidence, predictors, timing, and impact of bioprosthetic (BP) valve hemodynamic deterioration (VHD) assessed by Doppler-echocardiography. Methods: 1387 patients who underwent AVR and with at least 2 years of echo follow-up (62.2% male; 70.5±7.8 years old) were included in this retrospective study. Baseline echocardiography was performed at 4.1 (1.3-6.5) months post-AVR and echocardiographic follow-up was complete at 5-years post-AVR for 926 patients and at 10-years for 385 patients. VHD was defined as: ≥10mmHg increase in mean gradient (MG) and/or worsening of transprosthetic regurgitation ≥1/3 grade from baseline to last echocardiographic follow-up. Results: VHD occurred in 428 patients (30.9%). After comprehensive adjustment, VHD...
INFARCT CHARACTERISTICS, TREATMENT, AND CLINICAL OUTCOME IN PATIENTS WITH TRANSIENT ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION VERSUS ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION PATIENTS
Authors: Gladys Janssens, Nina van der Hoeven, Jorrit Lemkes, Maarten Van Leeuwen, Peter van de Ven, Stijn Brinckman, Jorik Timmer, Martijn Meuwissen, Arno Van Der Weerdt, Tim Ten Cate, Jan Piek, Clemens von Birgelen, Roberto Diletti, Javier Escaned, Albert van Rossum, Robin Nijveldt, Niels Van Royen
Journal: Journal of the American College of Cardiology (2019)
Abstract 488: <i>Clock</i> Regulates Autophagy and Cell Survival of Cardiac Myocytes During Hypoxia Stress
Authors: Inna Rabinovich-Nikitin, Illana Minuk, Victoria Margulets, Floribeth Aguilar, Tami A Martino, Lorrie A Kirshenbaum
Journal: Circulation Research (2018)

Circadian rhythms play a fundamental role in cell metabolism and tissue homeostasis and are influenced by the diurnal oscillation of cellular circadian clock genes. Zeitgebers influence the activation of the circadian rhythm by serving as molecular switches for the intrinsic cellular clock. Herein, we provide new evidence that hypoxia is a Zietgeber for the circadian rhythm and regulator of clock gene expression in cardiac myocytes. We further show that clock gene regulation promotes survival of cardiac myocytes by a mechanism that bi-directionally influences autophagy. Cardiac myocytes exhibited phasic oscillations in clock gene expression under basal conditions. Interestingly, in contrast to control cells, a marked time dependent decline in clock gene transcription was observed in cardiac myocytes subjected to hypoxia with maximal decline occurring at 18hrs. This coincided with a reciprocal increase in mitochondrial autophagy genes including beclin-1 . Loss of function mutations of clock that disrupted nuclear localization or DNA binding promoted wide-spread cell death. Hence, the findings of the present study provide the first direct evidence that hypoxia is a Zeitgeber for regulating Clock gene expression and cell survival of cardiac myocytes during hypoxic injury.
IRON ISOMALTOSIDE DIMINISHES ATRIAL ELECTRICAL INHOMOGENEITY IN CHRONIC HEART FAILURE WITHOUT ALTERING ATRIAL SIZE: A FERRIC-HF II SUBSTUDY
Authors: Hannah Jaumdally, Mohamad F. Barakat, Geoffrey Charles-Edwards, George Amin-Youssef, Ajay M. Shah, Paul Scott, Darlington O. Okonko
Journal: Journal of the American College of Cardiology (2019)
Abstract 20207: Deciphering and Exploiting MicroRNA-Target Interactomes in Human Cardiac Tissues
Authors: Congsheng Cheng, Ryan M Spengler, Frances L Johnson, Stravros G Drakos, Dean Y Li, Nikos Diakos, Beverly L Davidson, Ryan L Boudreau
Journal: Circulation (2014)

The orchestration of complex biological functions requires gene regulatory networks that are modulated, in part, by microRNAs (miRNAs). During the past decade, miRNAs have emerged as key biological...
SLAMF7high CD16negative Monocytes Increase in Peripheral Blood of Patients with Myelofibrosis in Correlation with JAK2V617F Mutation
Authors: Takaaki Maekawa, Shoichiro Kato, Yosuke Okada, Noriaki Tachi, Masahiro Teramoto, Toshikuni Kawamura, Yukiko Osawa, Shinichi Kobayashi, Ken Sato, Michihiro Hashimoto, Shinya Suzu, Kensuke Usuki, Soji Morishita, Marito Araki, Norio Komatsu, Fumihiko Kimura
Journal: Blood (2018)