tbuckley/cabot-search huggingface dataset:
Morbidity and mortality in carriers of the cystic fibrosis mutation <i>CFTR</i> Phe508del in the general population
Authors: Yunus Çolak, Børge G. Nordestgaard, Shoaib Afzal
Journal: European Respiratory Journal (2020)

Cystic fibrosis (CF) is caused by autosomal-recessive inheritance of a dysfunctional cystic fibrosis transmembrane conductance regulator (CFTR), up to 90% due to Phe508del mutation in the CFTR gene. We tested the hypothesis that CFTR Phe508del carriers have increased morbidity and mortality versus non-carriers in the general population. We genotyped 108 035 randomly selected white Danish individuals from the Copenhagen General Population Study (aged from 20–100 years) for CFTR Phe508del mutation (rs113993960). Risk of chronic bronchitis and airflow limitation was assessed cross-sectionally. Overall survival and risk of bronchiectasis, lung cancer, pneumonia, chronic rhinosinusitis, airway bleeding, spontaneous pneumothorax, respiratory failure, acute and chronic pancreatitis, liver cirrhosis, ileus, gastric and colorectal cancer, and male infertility were assessed prospectively during up to 15 years of follow-up (median: 9 years). A single individual was excluded due to homozygosity for CFTR Phe508del and known CF. No other individuals had diagnosed CF at baseline examination or during follow-up. Among the resulting 108 034 individuals, 105 176 (97%) were non-carriers and 2858 (3%) were carriers ( i.e. were heterozygous for CFTR Phe508del). Overall survival was similar between carriers and non-carriers. Compared to non-carriers and with multivariable adjustment, carriers had an odds ratio (OR) of 1.31 (95% CI 1.16–1.48) for chronic bronchitis, a hazard ratio (HR) of 1.88 (95% CI 1.03–3.45) for bronchiectasis and 1.52 (95% CI 1.12–2.08) for lung cancer. Carriers did not differ from non-carriers concerning lung function or any other morbidity outcomes as mentioned above. In the general population, carriers of CFTR Phe508del have a normal lifespan but an increased risk of chronic bronchitis (1.3-fold), bronchiectasis (1.9-fold) and lung cancer (1.5-fold).
Abstract 10910: Cu Importer CTR1 is a Redox Sensor That Promotes VEGFR2 Signaling and Angiogenesis
Authors: Archita Das, Dipankar Ash, Young-Mee Kim, Sudhahar Varadarajan, Yali Hou, Farlyn Z Hudson, Brian K Stansfield, Jack Kaplan, Tohru Fukai, Masuko Ushio-Fukai
Journal: Circulation (2019)

Introduction: Copper (Cu), an essential nutrient, and reactive oxygen species (ROS) play an important role in reparative angiogenesis with unknown mechanism. The Cu importer CTR1 at plasma membrane...
HEMORRHOIDAL DISEASE: SHORT AND LONG-TERM RESULTS OF RUBBER BAND LIGATION
Authors: S Nsibi, R Ennaifer, M Ayari, B Bouchabou, HB Nejma
Journal: Endoscopy (2020)

Aims Hemorrhoidal disease (HM) is probably the most frequent proctologic disorder. There are several therapeutic approaches: medical treatment, instrumental treatment in particularly band ligation and surgical treatment. Rubber band ligation of hemorrhoids (RBLH) remains the main instrumental treatment in our country. The aim of our study was to evaluate the short and long-term outcome of RBLH.
Prediction of Heart Failure Mortality in Emergent Care
Authors: Douglas S. Lee, Audra Stitt, Peter C. Austin, Therese A. Stukel, Michael J. Schull, Alice Chong, Gary E. Newton, Jacques S. Lee, Jack V. Tu
Journal: Annals of Internal Medicine (2012)

Computer models to predict the risk for short-term mortality among patients presenting to the emergency department (ED) with acute heart failure have been developed using factors derived among pati...
OUR EXPERIENCE IN EFTR OF COLORECTAL LESIONS USING THE FTRD
Authors: BB Cabredo, RMS Chumillas, LA Hernández, GH Bautista, ACM Urdaneta, MA Jiménez Moreno, JS Sánchez, IC Martín-Falquina, BS Aladrén
Journal: Endoscopy (2020)

Aims Full-thickness resection device (FTRD) is an over-the-scope system (Ovesco) which allows a single-step endoscopic full-thickness resection (EFTR). It is an emerging technique for the treatment of naive, residual or relapsing lesions, smaller than 25 mm. The aims of our study are to describe colorectal lesions resected by FTRD and evaluate its efficacy and safety.
Ciprofloxacin or Tamsulosin in Men with Chronic Prostatitis/Chronic Pelvic Pain Syndrome
Authors: Richard B. Alexander, Kathleen J. Propert, Anthony J. Schaeffer, J. Richard Landis, J. Curtis Nickel, Michael P. O'Leary, Michel A. Pontari, Mary McNaughton-Collins, Daniel A. Shoskes, Craig V. Comiter, Nand S. Datta, Jackson E. Fowler, Robert B. Nadler, Scott I. Zeitlin, Jill S. Knauss, Yanlin Wang, John W. Kusek, Leroy M. Nyberg, Mark S. Litwin
Journal: Annals of Internal Medicine (2004)

In this placebo-controlled trial, ciprofloxacin and tamsulosin (an α-adrenergic blocker) did not substantially reduce symptoms in men with moderate to severe symptoms from long-standing chronic pro...
RECURRENT NEOPLASIA AFTER ENDOSCOPIC TREATMENT FOR BARRETT’S NEOPLASIA IS RARE: RESULTS FROM A NATIONWIDE COHORT INCLUDING ALL 1,154 PATIENTS TREATED IN THE NETHERLANDS FROM 2008-2018
Authors: S van Munster, E.A. Nieuwenhuis, B Weusten, L Alvarez-Herrero, A Bogte, A Alkhalaf, B.E. Schenk, E Schoon, W Curvers, A.D. Koch, S.E.M. van de Ven, P.F.J. de Jonge, T Tang, W.B. Nagengast, F.T.M. Peters, J Westerhof, M.H.M.G. Houben, J.J.G.H.M. Bergman, R.E. Pouw
Journal: Endoscopy (2020)

Aims Radiofrequency ablation(RFA) +/- endoscopic resection(ER) is the standard of care for treatment of Barrett´s esophagus with early neoplasia(BE-neoplasia). We report outcomes for all patients treated in the Netherlands(NL) from 2008-2018, with uniform treatment and follow-up in centralized setting.
A computer-aided chem-photodynamic drugs self-delivery system for synergistically enhanced cancer therapy
Authors: Qiu Wang, Mengchi Sun, Chang Li, Dan Li, Zimeng Yang, Qikun Jiang, Zhonggui He, Huaiwei Ding, Jin Sun
Journal: Asian Journal of Pharmaceutical Sciences (2020)

The therapeutic strategy that gives consideration to the combination of photodynamic therapy and chemotherapy, has emerged as a potential development of effective anti-cancer medicine. Nevertheless, co-delivery of photosensitizers (PSs) and chemotherapeutic drugs in traditional carriers still remains great limitations due to low drug loadings and poor biocompatibility. Herein, we have utilized a computer-aided strategy to achieve a desired carrier-free self-delivery of pyropheophorbide a (PPa, a common PS) and podophyllotoxin (PPT, a classical chemotherapeutic drug) for synergistic cancer therapy. First, the computational simulation method identified the similar molecular sizes and rigid molecular structures between two drugs molecules. Based on the molecular docking, the intermolecular interactions were found to include π-π stackings, hydrophobic interactions and hydrogen bonds. Next, both drugs could co-assemble into nanoparticles (NPs) via one-step nanoprecipitation method. The various spectral experiments (UV, IR and FL) were conducted to evaluate the formation mechanism of spherical NPs. Moreover, in vitro and in vivo experiments systematically demonstrated that PPT/PPa NPs not only showed better cellular uptake efficiency, stronger cytotoxicity and higher accumulation in tumor sites, but also exhibited synergistic antitumor effect in female BALB/C bearing-4T1 tumor mice. Such a computer-aided design strategy of chem-photodynamic drugs self-delivery systems pave the way for efficient synergistic cancer therapy.
Maternal diesel particle exposure promotes offspring asthma through NK cell–derived granzyme B
Authors: Qian Qian, Bidisha Paul Chowdhury, Zehua Sun, Jerica Lenberg, Rafeul Alam, Eric Vivier, Magdalena M. Gorska
Journal: Journal of Clinical Investigation (2020)

Mothers living near high-traffic roads before or during pregnancy are more likely to have children with asthma. Mechanisms are unknown. Using a mouse model, here we showed that maternal exposure to diesel exhaust particles (DEP) predisposed offspring to allergic airway disease (AAD, murine counterpart of human asthma) through programming of their NK cells; predisposition to AAD did not develop in DEP pups that lacked NK cells and was induced in normal pups receiving NK cells from WT DEP pups. DEP NK cells expressed GATA3 and cosecreted IL-13 and the killer protease granzyme B in response to allergen challenge. Extracellular granzyme B did not kill, but instead stimulated protease-activated receptor 2 (PAR2) to cooperate with IL-13 in the induction of IL-25 in airway epithelial cells. Through loss-of-function and reconstitution experiments in pups, we showed that NK cells and granzyme B were required for IL-25 induction and activation of the type 2 immune response and that IL-25 mediated NK cell effects on type 2 response and AAD. Finally, experiments using human cord blood and airway epithelial cells suggested that DEP might induce an identical pathway in humans. Collectively, we describe an NK cell-dependent endotype of AAD that emerged in early life as a result of maternal exposure to DEP.
The Brain’s Glymphatic System: Current Controversies
Authors: Humberto Mestre, Yuki Mori, Maiken Nedergaard
Journal: Trends in Neurosciences (2020)

The glymphatic concept along with the discovery of meningeal lymphatic vessels have, in recent years, highlighted that fluid is directionally transported within the central nervous system (CNS). Imaging studies, as well as manipulations of fluid transport, point to a key role of the glymphatic-lymphatic system in clearance of amyloid-β and other proteins. As such, the glymphatic-lymphatic system represents a new target in combating neurodegenerative diseases. Not unexpectedly, introduction of a new plumbing system in the brain has stirred controversies. This opinion article will highlight what we know about the brain's fluid transport systems, where experimental data are lacking, and what is still debated.
EUS-GUIDED RADIOFREQUENCY ABLATION MID-TERM RESULTS (MORE THAN TWO YEARS FOLLOW-UP) FOR PANCREATIC NEUROENDOCRINE TUMOR AND PANCREATIC CYSTIC NEOPLASMS
Authors: M Gasmi, M Giovannini, N Lesavre, C Boustière, B Napoleon, S Koch, G Vanbervliet, J-M Gonzalez, M Barthet
Journal: Endoscopy (2020)

Aims Recent management with EUS-guided RFA for pancreatic NET and IPMN was recently investigated in a multicenter prospective study, The results were provided at one year-follow-up. We decided to extent the follow-up to at least two years. The primary endpoint of the study was the efficacy of EUS-RFA and the recurrence was the secondary endpoint.
AUTOMATED LINKAGE BETWEEN ENDOSCOPY AND HISTOPATHOLOGY AS A HOLY GRAIL FOR CONTINUOUS ADR50 MONITORING
Authors: G Rasschaert, L Duez, C Salem, C Musala, M Nkuize, P Eisendrath
Journal: Endoscopy (2020)

Aims ADR50 is considered by the European Society of Gastrointestinal Endoscopy (ESGE) as one of the key performance measures for lower gastrointestinal endoscopy. Technical and human resources constraints limit implementation of recording of quality monitoring in endoscopy. Our aim was to deploy a user friendly infrastructure for continuous monitoring of endoscopy quality indicators by establishing an automated linkage between endoscopy quality monitoring and the histopathology database.
Analogies for a No-Analog World: Tackling Uncertainties in Reintroduction Planning
Authors: ElizabethS. Forbes, Peter S. Alagona, Andrea J. Adams, Sarah E. Anderson, Kevin C. Brown, Jolie Colby, Scott D. Cooper, Sean M. Denny, Elizabeth H.T. Hiroyasu, Robert Heilmayr, Bruce E. Kendall, Jennifer A. Martin, Molly Hardesty-Moore, Alexis M. Mychajliw, Brian P. Tyrrell, Zoë S. Welch
Journal: Trends in Ecology & Evolution (2020)
AZD2171, an oral, highly potent VEGFR signaling inhibitor, in combination with gefitinib or paclitaxel: Results of a study in an orthotopic human lung adenocarcinoma model.
Authors: W J Wu, K Fujitaka, J Mandal, T Imagumbai, A Ryan, J Jurgensmeier, I J Fidler, M S O'Reilly, R S Herbst
Journal: Clinical Cancer Research (2005)
Adenylate cyclase activity along the rabbit nephron as measured in single isolated segments. 1975.
Authors: M Imbert, D Chabardès, M Montégut, A Clique, F Morel
Journal: Journal of the American Society of Nephrology (1997)

Biography: Classical Article: Historical Article: In Vitro: Journal Article: Portraits: Research Support, Non-U.S. Gov't: PDF Only
ENDOSCOPIC MANIPULATION INDUCES MINIMAL BUT REAL CHANGE OF Z-LINE APPEARANCE DURING ROUTINE ESOPHAGOGASTRODUODENOSCOPY
Authors: SH Lee, SJ Nam, SC Park, DH Choi, CD Kang, SJ Lee
Journal: Endoscopy (2020)

Aims We aimed to investigate the effect of endoscopic manipulation during esophagogastroduodenoscopy (EGD) on EGJ appearance and analyze whether this leads to significant changes on the grading of Los Angeles (LA) classification including minimal change.
喘息増悪のリスクに対する複数の屋外環境因子の短期効果:年齢層化時系列分析【JST・京大機械翻訳】
Authors: Lee Seung Won, Yon Dong Keon, C James Chase, Lee Shinhae, Koh Hyun Yong, Sheen Youn Ho, Oh Jae-Won, Han Man Yong, Sugihara George
Journal: Journal of Allergy and Clinical Immunology (2019)
Is surveillance colonoscopy necessary for all patients with bowel polyps?
Authors: Emma C Robbins, Kate Wooldrage, Amanda J Cross
Journal: BMJ (2020)

### What you need to know

Bowel cancer affects about 42 000 people in the UK annually with around 16 000 deaths.1 It can be prevented by removing adenomatous and serrated polyps, the main precursors.2 Some patients remain at increased risk after polypectomy, and guidelines recommend such patients undergo surveillance by colonoscopy for prevention and early detection of bowel cancer.345

In the UK, post-polypectomy surveillance accounts for 20% of colonoscopies, placing great pressure on endoscopy resources.6 Colonoscopy carries a small risk (<0.5%) of serious complications, including bowel perforation and severe bleeding.78 It is therefore vital to minimise the number of surveillance colonoscopies performed unnecessarily in patients unlikely to develop bowel cancer after polypectomy, while ensuring that patients at increased risk receive surveillance.

Recently updated guidelines in the UK recommend a one-off surveillance colonoscopy at three years in patients deemed at high risk of bowel cancer post-polypectomy (box 1).3 These updated guidelines incorporate new data on the long term risk of bowel cancer after polypectomy. However, uncertainty remains around the natural history of serrated polyps and diminutive (≤5 mm) adenomatous polyps, and whether patients with such polyps require surveillance colonoscopy.

Box 1 
### High risk criteria for future bowel cancer after polypectomy (2019 UK surveillance guidelines3)RETURN TO TEXT

### Data sources and selection strategy

We searched …
Association Between Prenatal Exposure to Alcohol and Tobacco and Neonatal Brain Activity
Authors: Lauren C. Shuffrey, Michael M. Myers, Joseph R. Isler, Maristella Lucchini, Ayesha Sania, Nicolò Pini, J. David Nugent, Carmen Condon, Timothy Ochoa, Lucy Brink, Carlie du Plessis, Hein J. Odendaal, Morgan E. Nelson, Christa Friedrich, Jyoti Angal, Amy J. Elliott, Coen Groenewald, Larry Burd, William P. Fifer
Journal: JAMA Network Open (2020)

<h3>Importance</h3> Research to date has not determined a safe level of alcohol or tobacco use during pregnancy. Electroencephalography (EEG) is a noninvasive measure of cortical function that has previously been used to examine effects of in utero exposures and associations with neurodevelopment. <h3>Objective</h3> To examine the association of prenatal exposure to alcohol (PAE) and tobacco smoking (PTE) with brain activity in newborns. <h3>Design, Setting, and Participants</h3> This prospective cohort study enrolled mother-newborn dyads from December 2011 through August 2015, with data analyzed from June 2018 through June 2019. Pregnant women were recruited from clinical sites in Cape Town, South Africa, and the Northern Plains region of the US. Participants were a subset of newborns enrolled in the Safe Passage Study. Exclusions included birth at less than 37 or more than 41 weeks' gestation, multiple birth, or maternal use of psychiatric medication during pregnancy. <h3>Exposures</h3> PAE and PTE groups were determined by cluster analysis. <h3>Main Outcomes and Measures</h3> Analyses of covariance were run on EEG spectral power at 12 scalp locations across the frequency spectrum from 1 to 45 Hz in 3-Hz bins by sleep state. <h3>Results</h3> The final sample consisted of 1739 newborns (median [interquartile range] gestational age at birth, 39.29 [1.57] weeks; 886 [50.9%] were female; median [interquartile range] newborn age at assessment, 48.53 [44.96] hours). Newborns whose mothers were in the low continuous (95% CI, −0.379 to −0.031;<i>P</i> &lt; .05; 95% CI, −0.379 to −0.045;<i>P</i> &lt; .05), quit (95% CI, −0.419 to −0.127;<i>P</i> &lt; .001; 95% CI, −0.398 to −0.106;<i>P</i> &lt; .005), and moderate or high continuous (95% CI, −0.430 to −0.124;<i>P</i> &lt; .001; 95% CI, −0.420 to −0.119;<i>P</i> &lt; .005) PAE clusters had increased 4- to 6-Hz and 7- to 9-Hz left-temporal EEG power. Newborns with moderate or high continuous PTE had decreased 19- to 21-Hz (95% CI, 0.034 to 0.327;<i>P</i> &lt; .05) and 22- to 24-Hz (95% CI, 0.022 to 0.316;<i>P</i> &lt; .05) right-central EEG compared with newborns with no PTE. Newborns with moderate or high continuous PTE had significantly decreased 22- to 36-Hz right-central EEG power compared with the quit smoking group (22-24 Hz, 95% CI, 0.001 to 0.579;<i>P</i> &lt; .05; 25-27 Hz, 95% CI, 0.008 to 0.586;<i>P</i> &lt; .05; 28-30 Hz, 95% CI, 0.028 to 0.607;<i>P</i> &lt; .05; 31-33 Hz, 95% CI, 0.038 to 0.617;<i>P</i> &lt; .05; 34-36 Hz, 95% CI, 0.057 to 0.636;<i>P</i> &lt; .05). <h3>Conclusions and Relevance</h3> These findings suggest that even low levels of PAE or PTE are associated with changes in offspring brain development.
IS SMALL BOWEL TRANSIT TIME A DETERMINANT FACTOR FOR THE DIAGNOSIS OF POTENTIALLY BLEEDING LESIONS AT CAPSULE ENDOSCOPY?
Authors: C Arieira, FD de Castro, PB Carvalho, B Rosa, MJ Moreira, J Cotter
Journal: Endoscopy (2020)

Aims Small bowel capsule endoscopy (SBCE) is the gold standard in the study of small bowel bleeding (SBB). Recent studies suggested that longer small bowel transit times (SBTT) may be associated with higher diagnostic yield of SBCE.The aim of the study is to investigate if longer SBTT is a predictive factor of positive findings on SBCE in a population that performed SBCE due to suspected SBB.
Phase I study of the PI3K alpha inhibitor BYL719 plus fulvestrant in patients with PIK3CA-altered and wild type ER+/HER2-locally advanced or metastatic breast cancer
Authors: F Janku, D Juric, J Cortes, H Rugo, H A Burris, M Schuler, B Deschler-Baier, M R Middleton, M Gil-Martin, J Berlin, E Winer, D Bootle, L Blumenstein, D Demanse, C Coughlin, C Quadt, J Baselga
Journal: Cancer Research (2015)
PREDICTORS OF POOR RESPONSE TO ENDOSCOPIC DILATION DURING ACHALASIA
Authors: FZ Hamdoun, H Abid, A Lamine, M Lahlali, N Lahmidani, M El Yousfi, M Abkari, A Ibrahimi, D-A Benajah
Journal: Endoscopy (2020)

Aims The purpose of this work is to identify predictive factors for poor response to endoscopic dilatation during achalasia.
Peroral endoscopic myotomy approach to treating a Killian–Jamieson diverticulum
Authors: Praneet Wander, Arvind Trindade, Petros C. Benias
Journal: Endoscopy (2020)

A 58-year-old man presented with dysphagia to pills, most solids, and some liquids. He also complained of regurgitation of food, either immediately or after 1 – 2 hours. He underwent a barium esophagram, which identified a cervical outpouching, which on further review was at the level of the upper esophageal sphincter, anterior and right lateral, suggesting that this was in fact a Killian–Jamieson (KJ) diverticulum rather than the more common Zenker’s diverticulum. KJ diverticula present anatomic challenges for any intervention, particularly because of the high risk of injury to the recurrent laryngeal nerve, which enters the neck at its base.
EFFICACY AND SAFETY OF DILATION-ASSISTED STONE EXTRACTION (DASE) AFTER ENDOSCOPIC SPHINCTEROTOMY (EST) FOR DIFFICULT BILIARY STONES: DATA FROM A SERIES IN A SINGLE REFERRAL CENTER
Authors: D Scimeca, ML Mastro, F Mocciaro, A Bonaccorso, E Conte, G Russo, RD Mitri
Journal: Endoscopy (2020)

Aims Endoscopic Sphincterotomy (EST) may not be effective for treating “difficult” common bile duct (CBD) stones or cases of complex bile duct access. Performing Dilation-Assisted Stone Extraction (DASE) after EST enhances technical success in stones extraction.
Guideline-based Consultation To Prevent Anticoagulant-related Bleeding
Authors: C. Seth Landefeld, Philip A. Anderson
Journal: Annals of Internal Medicine (2020)

Abstract ▪Objective:To test the efficacy of consultation designed to prevent anticoagulant-related bleeding. ▪Design:Randomized, controlled trial. ▪Setting:A large teaching hospital. ▪Patients:A to...
ENDOSCOPIC FULL-THICKNESS RESECTION (EFTR) OF COLORECTAL LESIONS WITH THE FULL-THICKNESS RESECTION DEVICE (FTRD): A RETROSPECTIVE ANALYSIS OF 55 CONSECUTIVE CASES
Authors: P Stathopoulos, E Gallmeier, TM Gress, C Denkert, U Denzer
Journal: Endoscopy (2020)

Aims EFTR is an emerging therapeutic option for endoscopic resection of lesions, which cannot be adequately and/or safely treated with conventional endoscopic techniques (EMR and ESD), such as epithelial neoplasia extending deeper than the mucosa or associated with significant fibrosis. In this single-center, retrospective study we aimed to evaluate the efficacy and safety of EFTR of colorectal lesions in various indications using the FTRD.
INCIDENCE AND SURVIVAL OF HEPATOCELLULAR CARCINOMA AND BILE DUCT CANCER IN PATIENTS WITH GALLSTONES OR CHOLECYSTECTOMY: A POPULATION-BASED COHORT STUDY
Authors: SM Park, HJ Kim, HS Ahn
Journal: Endoscopy (2020)

Aims It is debatable whether gallstones or cholecystectomy increase the risks of hepatocellular carcinoma (HCC) and bile duct cancer (BDC). We evaluated the risk and prognosis of HCC and BDC in patients with gallstones treated with or without cholecystectomy and compared them with healthy controls.