tbuckley/cabot-search huggingface dataset:
Exosome-orchestrated hypoxic tumor microenvironment
Authors: Wanrong Meng, Yaying Hao, Chuanshi He, Ling Li, Guiquan Zhu
Journal: Molecular Cancer (2019)

Hypoxic tumor microenvironment is a common feature of solid tumors and is associated with aggressiveness and poor patient outcomes. A continuous interference between cancer cells and stromal cells within the hypoxic microenvironment has been uncovered for its importance in cancer development and treatment responsiveness. Exosomes, initially considered as "garbage bins" for unwanted material from cells, are now elucidated to perform a variety of functions that involve interactions within the cellular microenvironment due to their ability to carry numerous cargoes, including lipids, proteins, nucleic acids, and metabolites. Exosome-mediated continuous interference between cancer cells and stroma are believed to regulate hypoxia-adaptation and to rebuild the microenvironment in return. In this review, we will discuss the knowledge in literature with respect to the exosome-mediated multi-directional and mutual signal transmission among the variety of cell types within hypoxic cancer microenvironment.
RESULTS OF A SPANISH NATIONAL SURVEY OF CAPSULE ENDOSCOPY
Authors: C Carretero, M Lujan, M Sanjuan, F Argüelles, I Fernandez-Urien, B Gonzalez, E Perez-Cuadrado Robles, F Sanchez, J Valle, O Nogales, V Pons
Journal: Endoscopy (2019)

153 capsule readers answered the survey, 60.1% experienced (> 5 years) and 60.2% having attended a dedicated capsule course. 49.7% lack specific reading time within their working schedule.
Comparative Efficacy and Speed of Onset of Action of Infliximab vs Golimumab in Ulcerative Colitis
Authors: Siddharth Singh, James A. Proudfoot, Parambir S. Dulai, Ronghui Xu, Brian G. Feagan, William J. Sandborn, Vipul Jairath
Journal: Clinical Gastroenterology and Hepatology (2019)
AUTOMATED POLYP DIFFERENTIATION ON COLOSCOPIC DATA USING SEMANTIC SEGMENTATION WITH CNNS
Authors: M Arlt, J Peter, S Sickert, CA Brust, J Denzler, A Stallmach
Journal: Endoscopy (2019)

Interval carcinomas are a commonly known problem in endoscopic adenoma detection, especially when they follow negative index colonoscopy. To prevent patients from these carcinomas and support the endoscopist, we reach for a live assisted system in the future, which helps to remark polyps and increase adenoma detection rate. We present our first results of polyp recognition using a machine learning approach.
E-PATIENT COUNSELING TRIAL (E-PACO): COMPUTER BASED PATIENT EDUCATION IS NON-INFERIOR TO NURSE COUNSELING PRIOR TO COLONOSCOPY, A MULTICENTER RANDOMIZED CONTROLLED TRIAL
Authors: G Veldhuijzen, M Klemt-Kropp, JS Terhaar sive Droste, B van Balkom, AAJ van Esch, JPH Drenth
Journal: Endoscopy (2019)

Optimal patient education prior to colonoscopy improves adherence to instructions for bowel preparation and leads to cleaner colons. We developed a computer based education (CBE) supported by video and 3D animations. We hypothesized that CBE may replace current nurse counseling (NC) in most cases, without losing quality of bowel cleanliness during colonoscopy.
National, regional, and worldwide estimates of stillbirth rates in 2009 with trends since 1995: a systematic analysis
Authors: Simon Cousens, Hannah Blencowe, Cynthia Stanton, Doris Chou, Saifuddin Ahmed, Laura Steinhardt, Andreea A Creanga, Özge Tunçalp, Zohra Patel Balsara, Shivam Gupta, Lale Say, Joy E Lawn
Journal: The Lancet (2011)
Questioning the Higher Abscess Rate and Overall Cost of Care Associated With Nonoperative Management of Uncomplicated Acute Appendicitis
Authors: Paulina Salminen, Juha Grönroos
Journal: JAMA Surgery (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
ENDOSCOPIC SIGMOIDOPEXY AS A TREATMENT FOR RECURRENT SIGMOID VOLVULUS IN FRAIL PATIENTS
Authors: L Quénéhervé, E Coron
Journal: Endoscopy (2019)

Sigmoid volvulus is a common cause of colonic obstruction in old and frail patients. Its standard management includes the endoscopic detorsion of the colonic loop, followed by an elective sigmoidectomy to prevent recurrence. However, these patients are often poor candidates for surgery. In frail patients, other options such as endoscopic sigmoidopexy must be developed.
A guide for respiratory physiotherapy postgraduate education: presentation of the harmonised curriculum
Authors: Thierry Troosters, Daniel Langer, Chris Burtin, Michelle Chatwin, Enrico M. Clini, Margareta Emtner, Rik Gosselink, Kathleen Grant, Deniz Inal-Ince, Agnieszka Lewko, Eleanor Main, Beatrice Oberwaldner, Nathalie Tabin, Fabio Pitta
Journal: European Respiratory Journal (2019)

<b>The ERS respiratory physiotherapy curriculum sets a new standard for postgraduate respiratory physiotherapy education. It was developed to promote evidence-based practice and physical skills for the respiratory physiotherapist.</b>http://bit.ly/2LwJ0mb
Serologic screening before endoscopy: the value of serum recognition of the Helicobacter pylori CagA protein in patients up to 45 years of age
Authors: Tajana Filipec Kanizaj, Miroslava Katicic, Vladimir Presecki, Branko Papa, Marija Prskalo, Vesna Colic-Cvrlje, Mirjana Ticak, Slavica Naumovski-Mihalic, Branka Sabaric, Bruno Skurla
Journal: Gut (2004)
LONG-TERM OUTCOMES OF COLORECTAL ENDOSCOPIC SUBMUCOSAL DISSECTION: EXPERIENCE IN A WESTERN CENTRE
Authors: J Arribas Anta, Á Cañete Ruiz, T Álvarez-Nava Torrego, C Piedracoba Cadahía, DR De la Cruz Esteban, M Rodriguez Carrasco, E Romero Romero, A Del Pozo García, JB Díaz Tasende, JC Marín Gabriel
Journal: Endoscopy (2019)

To analyze long-term follow-up after endoscopic submucosal dissection (ESD) and to compare recurrence rates according to different variables.
Next steps towards universal health coverage call for global leadership
Authors: Gerald Bloom, Yasushi Katsuma, Krishna D Rao, Saeda Makimoto, Jason D C Yin, Gabriel M Leung
Journal: BMJ (2019)

Universal health coverage (UHC) has been identified as a priority for international development by the G20, the World Health Organization, and the United Nations General Assembly.Since it was explicitly incorporated into the sustainable development goals (SDGs) as target 3.8, much effort has been expended on promoting UHC.Here we focus on four areas that, on current trajectories, are unlikely to achieve sufficient progress to meet the target.These are also areas for which G20 can provide substantial leverage: the principle of "leaving no one behind," particularly in migrant health and genuine support for primary care; reliable domestic financing, which requires enlightened leadership and deliberate dialogue between finance and health sectors; harnessing and regulating medical and technological innovation; and mutual learning and harmonised aid among donor countries.We call on G20 leaders, who will meet in Osaka in June 2019, to take concrete action on these issues.This article is based on a policy brief prepared by a working group convened by the Government of Japan as host of the Think 20 summit in Tokyo in May 2019. 1 Our work has received input from a wide ranging global group of thought leaders, some of whom represent civil society, including patients and the general public. Leaving no one behindSubstantial inequities in access to affordable quality healthcare remain both within and between countries.Vulnerable populations face greater morbidity and premature mortality from easily preventable and treatable causes.Such inequities also threaten human security.
A RANDOMIZED CONTROLLED TRIAL ON THE CONTRAST ENHANCED GUIDED EUS-FNA AGAINST STANDARD EUS-FNA IN DIAGNOSING THE SOLID PANCREATIC LESIONS
Authors: A Seicean, A Samarghitan, C Pojoga, I Rusu, M Gheorghiu, Z Sparchez, N Al Hajjar, R Seicean
Journal: Endoscopy (2019)

To assess the efficiency of the contrast enhanced guided endoscopic ultrasound fine needle aspiration (CH-EUS-FNA) in comparison to standard endoscopic ultrasound fine needle aspiration (EUS-FNA) in diagnosing the solid pancreatic masses.
CAN SERT SCORE PREDICT HISTOLOGICAL RECURRENCE IN PIECEMEAL ENDOSCOPIC MUCOSAL RESECTION? – A COMPARATIVE STUDY WITH SMSA SCORE
Authors: JC Silva, R Pinho, AP Silva, A Ponte, J Rodrigues, M Sousa, AC Gomes, J Carvalho
Journal: Endoscopy (2019)

Piecemeal endoscopic mucosal resection (pEMR) allows the resection of larger non-invasive colorectal lesions. Prediction of histological recurrence (HR), as determined in the first surveillance colonoscopy, is still a limitation. The recently described SERT score (Sydney EMR-recurrence tool) can predict endoscopic recurrence (ER), however it was not evaluated as a predictor of HR. The present study aimed to validate the SERT score as a predictor of ER and HR as to compare it with the SMSA score (size, morphology, site, access) already validated as a predictor.
GRADING SUCCESS AND COMPLICATIONS IN ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY (ERCP): THE AUSTRIAN SUCCESS AND COMPLICATION SCORE IN ERCP (ASCE – SCORE) A NOVEL GRADING SYSTEM
Authors: A Maieron, E Steiner, C Duller, M Schmidt, A Püspöck, C Kapral
Journal: Endoscopy (2019)

The need for standardized benchmarks in endoscopic retrograde cholangiopancreatography (ERCP) has become a pressing matter in quality control and training supervision. The aim of this study was to evaluate and adapt the grading system for ERCP proposed by the American Society for Gastrointestinal Endoscopy (ASGE) 2011 by using a large-scale multicentre data set.
EUS GUIDED LUMINAL REMODELING AS A NOVEL TECHNIQUE TO RESTORE GASTRODUODENAL CONTINUITY
Authors: H El Bacha, C Jung, B Brieau, B Bordacahar, S Leblanc, M Barret, A de Chaumont, B Dousset, F Prat
Journal: Endoscopy (2019)

Pyloric closure is a method of treatment for duodenal injury. Surgery is usually needed to restore digestive continuity in due time, yet a new surgical procedure can be challenging due to fibrotic adhesion development.
The State of the Science on Prostate Cancer Biomarkers: The San Francisco Consensus Statement
Authors: Matthew R. Cooperberg, Peter R. Carroll, Marc A. Dall’Era, Benjamin J. Davies, John W. Davis, Scott E. Eggener, Felix Y. Feng, Daniel W. Lin, Todd M. Morgan, Alicia K. Morgans, Daniel E. Spratt, Samir S. Taneja, David F. Penson
Journal: European Urology (2019)
Response to Comment on Feig et al. Pumps or Multiple Daily Injections in Pregnancy Involving Type 1 Diabetes: A Prespecified Analysis of the CONCEPTT Randomized Trial. Diabetes Care 2018;41:2471–2479
Authors: Denice S. Feig, Rosa Corcoy, Lois E. Donovan, Kellie E. Murphy, Jon F.R. Barrett, J. Johanna Sanchez, Katrina Ruedy, Craig Kollman, George Tomlinson, Helen R. Murphy
Journal: Diabetes Care (2019)

We thank Sacha and Lane (1) for their interest in our multicenter, multinational randomized Continuous Glucose Monitoring in Women With Type 1 Diabetes in Pregnancy Trial (CONCEPTT). First, we should clarify that the randomized controlled trial was designed to evaluate the impact of continuous glucose monitoring (CGM) in women with type 1 diabetes (T1D) who were pregnant or planning pregnancy (2). Of note, CGM was beneficial on a range of maternal second and third trimester glycemic outcomes, with a halving in the odds ratio for neonatal large for gestational age, neonatal hypoglycemia, and neonatal intensive care unit admissions >24 h (3). Furthermore, the treatment effect of CGM was comparable across 31 international sites and between women using insulin pumps and contemporary multiple daily injection (MDI) regimens. Given the paucity of randomized trial data comparing insulin pumps with MDI using contemporary fast- and long-acting …
Techniques utilisées pour les cathétérismes pancréatiques thérapeutiques difficiles
Authors: R Alhameedi, L Thomassin, S Lecleire
Journal: Endoscopy (2019)

Le cathétérisme pancréatique est un vrai challenge pour les endoscopistes. Les difficultés dans cette procédure sont très fréquente. Il existe plusieurs techniques endoscopiques utilisées pour le cathétérisme difficile, les techniques utilisées sont: double fils guide, dilatation du Wirsung, pre-coupe pancréatique et la pose d'une prothèse biliaire plastique.
Cost-effectiveness of routine and campaign use of typhoid Vi-conjugate vaccine in Gavi-eligible countries: a modelling study
Authors: Joke Bilcke, Marina Antillón, Zoë Pieters, Elise Kuylen, Linda Abboud, Kathleen M Neuzil, Andrew J Pollard, A David Paltiel, Virginia E Pitzer
Journal: The Lancet Infectious Diseases (2019)

BackgroundTyphoid fever is a major cause of morbidity and mortality in low-income and middle-income countries. In 2017, WHO recommended the programmatic use of typhoid Vi-conjugate vaccine (TCV) in endemic settings, and Gavi, The Vaccine Alliance, has pledged support for vaccine introduction in these countries. Country-level health economic evaluations are now needed to inform decision-making.MethodsIn this modelling study, we compared four strategies: no vaccination, routine immunisation at 9 months, and routine immunisation at 9 months with catch-up campaigns to either age 5 years or 15 years. For each of the 54 countries eligible for Gavi support, output from an age-structured transmission-dynamic model was combined with country-specific treatment and vaccine-related costs, treatment outcomes, and disability weights to estimate the reduction in typhoid burden, identify the strategy that maximised average net benefit (ie, the optimal strategy) across a range of country-specific willingness-to-pay (WTP) values, estimate and investigate the uncertainties surrounding our findings, and identify the epidemiological conditions under which vaccination is optimal.FindingsThe optimal strategy was either no vaccination or TCV immunisation including a catch-up campaign. Routine vaccination with a catch-up campaign to 15 years of age was optimal in 38 countries, assuming a WTP value of at least US$200 per disability-adjusted life-year (DALY) averted, or assuming a WTP value of at least 25% of each country's gross domestic product (GDP) per capita per DALY averted, at a vaccine price of $1·50 per dose (but excluding Gavi's contribution according to each country's transition phase). This vaccination strategy was also optimal in 48 countries assuming a WTP of at least $500 per DALY averted, in 51 with assumed WTP values of at least $1000, in 47 countries assuming a WTP value of at least 50% of GDP per capita per DALY averted, and in 49 assuming a minimum of 100%. Vaccination was likely to be cost-effective in countries with 300 or more typhoid cases per 100 000 person-years. Uncertainty about the probability of hospital admission (and typhoid incidence and mortality) had the greatest influence on the optimal strategy.InterpretationCountries should establish their own WTP threshold and consider routine TCV introduction, including a catch-up campaign when vaccination is optimal on the basis of this threshold. Obtaining improved estimates of the probability of hospital admission would be valuable whenever the optimal strategy is uncertain.FundingBill & Melinda Gates Foundation, Research Foundation–Flanders, and the Belgian–American Education Foundation.
JAK2 Exon 12 Mutated Polycythemia Vera: The Mayo Clinic-University of Florence Experience with 33 Consecutive Cases and Comparison with JAK2 V617F Mutated Disease
Authors: Ayalew Tefferi, Sravanthi Lavu, Terra L. Lasho, Christy Finke, Naseema Gangat, Animesh Pardanani, Curtis A. Hanson, Carmela Mannarelli, Paola Guglielmelli, Alessandro M. Vannucchi
Journal: Blood (2017)
DEVELOPMENT OF A NEW CLASSIFICATION SYSTEM TO ASSESS MUCOSAL HEALING IN INFLAMMATORY BOWEL DISEASE (IBD) USING NARROW BAND IMAGING (NBI) WITHOUT OPTICAL MAGNIFICATION
Authors: E Wedi, KF Rahman, F Thieringer, PR Galle, H Neumann
Journal: Endoscopy (2019)

NBI is based on optical filters narrowing the red light therefore highlighting the vascular pattern morphology of the luminal gastrointestinal tract. Assessment of vascular changes in IBD is of pivotal importance for prediction of mucosal healing and for guidance of pharmaceutical therapies. To date, only limited data is available on the use of NBI for assessment of mucosal healing in IBD.
Dipeptidyl Peptidase 4 Inhibitors and Risk of Inflammatory Bowel Disease Among Patients With Type 2 Diabetes: A Meta-analysis of Randomized Controlled Trials
Authors: Guangyao Li, Matthew J. Crowley, Huilin Tang, Jeff Y. Yang, Robert S. Sandler, Tiansheng Wang
Journal: Diabetes Care (2019)

A recent retrospective cohort study found that new use of dipeptidyl peptidase 4 inhibitors (DPP4i) of 1.6 years was associated with an increased risk of inflammatory bowel disease (IBD) compared with other antidiabetes medications (hazard ratio 1.75 (95% CI 1.22, 2.49) (1). We previously demonstrated a weak association in an analysis of 86 prevalent and incident cases of IBD among DPP4i users using the U.S. Food and Drug Administration's Adverse Event Reporting System (2). In contrast, a cohort study suggested DPP4i initiation reduces risk of autoimmune diseases including IBD (3). Because the link between DPP4i and IBD remains uncertain, we performed a meta-analysis of randomized controlled trials (RCTs) to evaluate this potential association among patients with type 2 diabetes (T2D).

This meta-analysis is registered with the international prospective register of systematic reviews (PROSPERO) (no. CRD42018095206). We systematically searched PubMed, Embase, the Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov from inception to 28 April 2018 to identify DPP4i trials in T2D patients that explicitly reported IBD events. The large-scale cardiovascular trial for linagliptin (CARMELINA trial [4]) was published 7 months after our search; we therefore included this study. Two reviewers independently performed study selection, data extraction, and quality assessment. The primary outcome …
Retrieval of a large resected specimen using a large-caliber cap after colorectal endoscopic submucosal dissection
Authors: Yuichiro Kuroki, Kunio Asonuma, Natsumi Uehara, Toshiyuki Endo, Reika Suzuki, Yorimasa Yamamoto, Masatsugu Nagahama
Journal: Endoscopy (2019)

Endoscopic submucosal dissection (ESD) has emerged as a feasible treatment option for colorectal tumors [1]. However, large colorectal specimens obtained via ESD that are difficult to retrieve from the anal canal are often encountered. We have experienced a few cases of specimen fragmentation during retrieval. Precise histological evaluation requires an intact specimen and fragmentation should be avoided. Several recent reports have described useful techniques for the retrieval of intact resected specimens [2] [3] [4]; however, these reported methods are relatively complex. We describe a more convenient and easy way of retrieving resected specimens using a large-caliber cap.
Early evaluation using a radiomic signature of unresectable hepatic metastases to predict outcome in patients with colorectal cancer treated with FOLFIRI and bevacizumab
Authors: Anthony Dohan, Benoit Gallix, Boris Guiu, Karine Le Malicot, Caroline Reinhold, Philippe Soyer, Jaafar Bennouna, Francois Ghiringhelli, Emilie Barbier, Valérie Boige, Julien Taieb, Olivier Bouché, Eric François, Jean-Marc Phelip, Christian Borel, Roger Faroux, Jean-Francois Seitz, Stéphane Jacquot, Meher Ben Abdelghani, Faiza Khemissa-Akouz, Dominique Genet, Jean Louis Jouve, Yves Rinaldi, Françoise Desseigne, Patrick Texereau, Etienne Suc, Come Lepage, Thomas Aparicio, Christine Hoeffel
Journal: Gut (2019)

The objective of this study was to build and validate a radiomic signature to predict early a poor outcome using baseline and 2-month evaluation CT and to compare it to the RECIST1·1 and morphological criteria defined by changes in homogeneity and borders.This study is an ancillary study from the PRODIGE-9 multicentre prospective study for which 491 patients with metastatic colorectal cancer (mCRC) treated by 5-fluorouracil, leucovorin and irinotecan (FOLFIRI) and bevacizumab had been analysed. In 230 patients, computed texture analysis was performed on the dominant liver lesion (DLL) at baseline and 2 months after chemotherapy. RECIST1·1 evaluation was performed at 6 months. A radiomic signature (Survival PrEdiction in patients treated by FOLFIRI and bevacizumab for mCRC using contrast-enhanced CT TextuRe Analysis (SPECTRA) Score) combining the significant predictive features was built using multivariable Cox analysis in 120 patients, then locked, and validated in 110 patients. Overall survival (OS) was estimated with the Kaplan-Meier method and compared between groups with the logrank test. An external validation was performed in another cohort of 40 patients from the PRODIGE 20 Trial.In the training cohort, the significant predictive features for OS were: decrease in sum of the target liver lesions (STL), (adjusted hasard-ratio(aHR)=13·7, p=1·93×10-7), decrease in kurtosis (ssf=4) (aHR=1·08, p=0·001) and high baseline density of DLL, (aHR=0·98, p<0·001). Patients with a SPECTRA Score >0·02 had a lower OS in the training cohort (p<0·0001), in the validation cohort (p<0·0008) and in the external validation cohort (p=0·0027). SPECTRA Score at 2 months had the same prognostic value as RECIST at 6 months, while non-response according to RECIST1·1 at 2 months was not associated with a lower OS in the validation cohort (p=0·238). Morphological response was not associated with OS (p=0·41).A radiomic signature (combining decrease in STL, density and computed texture analysis of the DLL) at baseline and 2-month CT was able to predict OS, and identify good responders better than RECIST1.1 criteria in patients with mCRC treated by FOLFIRI and bevacizumab as a first-line treatment. This tool should now be validated by further prospective studies.Clinicaltrial.gov identifier of the PRODIGE 9 study: NCT00952029.Clinicaltrial.gov identifier of the PRODIGE 20 study: NCT01900717.
In adolescents and young adults, dental-related opioid prescriptions were linked to subsequent opioid use and abuse
Authors: Nancy J. Heisel
Journal: Annals of Internal Medicine (2019)

Source Citation Schroeder AR, Dehghan M, Newman TB, Bentley JP, Park KT. Association of opioid prescriptions from dental clinicians for US adolescents and young adults with subsequent opioid use and abuse. JAMA Intern Med. 2018;179:145-52. 30508022
Radiation-Induced DNA Damage Cooperates with Heterozygosity of TP53 and PTEN to Generate High-Grade Gliomas
Authors: Pavlina K. Todorova, Eliot Fletcher-Sananikone, Bipasha Mukherjee, Rahul Kollipara, Vamsidhara Vemireddy, Xian-Jin Xie, Peter M. Guida, Michael D. Story, Kimmo Hatanpaa, Amyn A. Habib, Ralf Kittler, Robert Bachoo, Robert Hromas, John R. Floyd, Sandeep Burma
Journal: Cancer Research (2019)

Glioblastomas are lethal brain tumors that are treated with conventional radiation (X-rays and gamma rays) or particle radiation (protons and carbon ions). Paradoxically, radiation is also a risk factor for GBM development, raising the possibility that radiotherapy of brain tumors could promote tumor recurrence or trigger secondary gliomas. In this study, we determined whether tumor suppressor losses commonly displayed by patients with GBM confer susceptibility to radiation-induced glioma. Mice with Nestin-Cre-driven deletions of