tbuckley/cabot-search huggingface dataset:
TCT-12 Clinical, Angiographic and Procedural Correlates of Very Late Absorb Scaffold Thrombosis – Multi-Study Registry Results
Authors: Stephen Ellis, Tommaso Gori, Patrick Serruys, Giuseppe Steffenino, Salvatore Brugaletta, Cordula Felix, Götz Schmidt, Manel Sabate, Yoshinobu Onuma, Run-Lin Gao, Maurizio Menichelli, Dean Kereiakes, Takeshi Kimura, Gregg Stone, Alexandre Abizaid
Journal: Journal of the American College of Cardiology (2017)
SETD2 deficiency accelerates MDS-associated leukemogenesis via S100a9 in NHD13 mice and predicts poor prognosis in MDS
Authors: Bing-Yi Chen, Junhong Song, Cheng-Long Hu, Shu-Bei Chen, Qunling Zhang, Chun-Hui Xu, Ji-Chuan Wu, Dan Hou, Ming Sun, Yuan-Liang Zhang, Na Liu, Peng-Cheng Yu, Ping Liu, Li-Juan Zong, Jia-Ying Zhang, Ruo-Fei Dai, Fei Lan, Qiu-Hua Huang, Su-Jiang Zhang, Stephen D. Nimer, Zhu Chen, Sai-Juan Chen, Xiao-Jian Sun, Lan Wang
Journal: Blood (2020)
PROGNOSTIC VALUE OF BASELINE AND CHANGES IN CIRCULATING SOLUBLE ST2 LEVELS AND THE EFFECTS OF NESIRITIDE IN ACUTE DECOMPENSATED HEART FAILURE
Authors: Wai Hong Wilson Tang, Amy Hsu, Adrian Hernandez, Javed Butler, Marco Metra, G. Michael Felker, Adriaan Voors, Richard Troughton, Roger Mills, John McMurray, Paul Armstrong, Robert Califf, Christopher O’Connor, Randall Starling
Journal: Journal of the American College of Cardiology (2015)
TCT-855 Chronic Obstructive Pulmonary Disease in Patients Undergoing Transcatheter Aortic Valve Implantation: Insights on Clinical Outcomes, Prognostic Markers and Functional Status Changes
Authors: Michael Mok, Eric Dumont, Luis Nombela-Franco, Marina Urena, Robert De Larochelliere, Daniel Doyle, Jacques Villeneuve, Melanie Coté, Paul Poirier, Philippe Pibarot, Francois Maltais, Josep Rodes-Cabau
Journal: Journal of the American College of Cardiology (2012)
TCTAP A-174 Left Ventricular Mass Index and Septal E/E' Ratio Is Associated with Coronary Artery Calcium Score Severity in Subjects with Normal Left Ventricular Ejection Fraction
Authors: Sang-Ho Park, Seung-Woon Rha, Won-Yong Shin, Seung-Jin Lee, Dong-Kyu Jin, Byoung Geol Choi, Se Yeon Choi, Yoonjee Park, Akkala Raghavender Goud, Hu Li, Sunki Lee, Ji Bak Kim, Sung Il Im, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh
Journal: Journal of the American College of Cardiology (2014)
JNK suppresses melanogenesis by interfering with CREB-regulated transcription coactivator 3-dependent MITF expression
Authors: Ji-Hye Kim, A-reum Hong, Yo-Han Kim, Hanju Yoo, Sang-Wook Kang, Sung Eun Chang, Youngsup Song
Journal: Theranostics (2020)

Melanogenesis is a critical self-defense mechanism against ultraviolet radiation (UVR)-induced skin damage and carcinogenesis; however, dysregulation of melanin production and distribution causes skin-disfiguring pigmentary disorders.Melanogenesis is initiated by UVR-induced cAMP generation and ensuing activation of transcription factor CREB, which induces expression of the master melanogenic regulator MITF.Recent studies have demonstrated that recruitment of CRTCs to the CREB transcription complex is also required for UVR-stimulated melanogenesis.Therefore, modulation of cAMP -CRTC/CREB -MITF signaling may be a useful therapeutic strategy for UVR-associated skin pigmentary disorders.Methods: We identified the small-molecule Ro31-8220 from CREB/CRTC activity screening and examined its melanogenic activity in cultured mouse and human melanocytes as well as in human skin.Molecular mechanisms were deciphered by immunoblotting, RT-PCR, promoter assays, tyrosinase activity assays, immunofluorescent examination of CRTC3 subcellular localization, and shRNA-based knockdown.Results: Ro31-8220 suppressed basal and cAMP-stimulated melanin production in melanocytes and human melanocyte co-culture as well as UVR-stimulated melanin accumulation in human skin through downregulation of MITF and tyrosinase expression.Mechanistically, down regulation of MITF expression by Ro31-8220 was due to inhibition of transcriptional activity of CREB, which was resulted from phosphorylation-dependent blockade of nuclear translocation of CRTC3 via JNK activation.The selective JNK activator anisomycin also inhibited melanin production through phosphoinhibition of CRTC3, while JNK inhibition enhanced melanogenesis by stimulating CRTC3 dephosphorylation and nuclear migration.Conclusions: Melanogenesis can be enhanced or suppressed via pharmacological modulation of a previously unidentified JNK-CRTC/CREB-MITF signaling axis.As Ro31-8220 potently inhibits UVR-stimulated melanin accumulation in human skin, suggesting that small-molecule JNK-CRTC signaling modulators may provide therapeutic benefit for pigmentation disorders.
Isoflavone Intake and the Risk of Coronary Heart Disease in US Men and Women
Authors: Le Ma, Gang Liu, Ming Ding, Geng Zong, Frank B. Hu, Walter C. Willett, Eric B. Rimm, JoAnn E. Manson, Qi Sun
Journal: Circulation (2020)

Whether soy products confer health benefits related to coronary heart disease (CHD) remains controversial because of inconsistent evidence.A total of 74 241 women from the NHS (Nurses' Health Study; 1984-2012), 94 233 women from the NHSII (Nurses' Health Study II; 1991-2013), and 42 226 men from the Health Professionals Follow-Up Study (1986-2012), who were free of cardiovascular disease and cancer at baseline, were included in the present analysis. Dietary data were updated every 2 to 4 years using a validated food frequency questionnaire. Nonfatal myocardial infarction and CHD deaths were adjudicated through reviewing medical records, death certificates, and other medical documents.In these cohorts, 8359 incident CHD cases were documented during 4 826 122 person-years of follow-up. In multivariable-adjusted analyses, isoflavone intake was inversely associated with CHD (pooled hazard ratio [HR] comparing the extreme quintiles: 0.87 [95% CI, 0.81-0.94]; P=0.008). Consumption of tofu, but not soy milk, was inversely associated with the risk of CHD, with pooled HRs (95% CIs) of 0.82 (0.70-0.95; P=0.005) and 0.87 (0.69-1.10; P=0.41), respectively, comparing ≥1 serving/week with <1 serving/month. Further analyses showed that, in women, the favorable association of tofu was primarily driven by stronger inverse association of tofu intake observed in younger women before menopause and postmenopausal women without hormone use (Pinteraction=0.002).Higher intake of isoflavones and tofu was associated with a moderately lower risk of developing CHD, and in women the favorable association of tofu were more pronounced in young women or postmenopausal women without hormone use.
IMPACT OF PRASUGREL RELOAD DOSING REGIMENS ON HIGH ON–TREATMENT PLATELET REACTIVITY RATES IN PATIENTS ON MAINTENANCE PRASUGREL THERAPY
Authors: Jose Luis Ferreiro, Masafumi Ueno, Antonio Tello–Montoliu, Salvatore Tomasello, Naveen Seecheran, Bhaloo Desai, Fabiana Rollini, Luis Guzman, Theodore Bass, Dominick Angiolillo
Journal: Journal of the American College of Cardiology (2013)
Population pharmacokinetics of colistin and the relation to survival in critically ill patients infected with colistin susceptible and carbapenem-resistant bacteria
Authors: A.N. Kristoffersson, V. Rognås, M.J.E. Brill, Y. Dishon-Benattar, E. Durante-Mangoni, V. Daitch, A. Skiada, J. Lellouche, A. Nutman, A. Kotsaki, R. Andini, N. Eliakim-Raz, R. Bitterman, A. Antoniadou, M.O. Karlsson, U. Theuretzbacher, L. Leibovici, G.L. Daikos, J.W. Mouton, Y. Carmeli, M. Paul, L.E. Friberg
Journal: Clinical Microbiology and Infection (2020)

ObjectivesThe aim was to analyse the population pharmacokinetics of colistin and to explore the relationship between colistin exposure and time to death.MethodsPatients included in the AIDA randomized controlled trial were treated with colistin for severe infections caused by carbapenem-resistant Gram-negative bacteria. All subjects received a 9 million units (MU) loading dose, followed by a 4.5 MU twice daily maintenance dose, with dose reduction if creatinine clearance (CrCL) < 50 mL/min. Individual colistin exposures were estimated from the developed population pharmacokinetic model and an optimized two-sample per patient sampling design. Time to death was evaluated in a parametric survival analysis.ResultsOut of 406 randomized patients, 349 contributed pharmacokinetic data. The median (90% range) colistin plasma concentration was 0.44 (0.14–1.59) mg/L at 15 minutes after the end of first infusion. In samples drawn 10 hr after a maintenance dose, concentrations were >2 mg/L in 94% (195/208) and 44% (38/87) of patients with CrCL ≤120 mL/min, and >120 mL/min, respectively. Colistin methanesulfonate sodium (CMS) and colistin clearances were strongly dependent on CrCL. High colistin exposure to MIC ratio was associated with increased hazard of death in the multivariate analysis (adjusted hazard ratio (95% CI): 1.07 (1.03–1.12)). Other significant predictors included SOFA score at baseline (HR 1.24 (1.19–1.30) per score increase), age and Acinetobacter or Pseudomonas as index pathogen.DiscussionThe population pharmacokinetic model predicted that >90% of the patients had colistin concentrations >2 mg/L at steady state, but only 66% at 4 hr after start of treatment. High colistin exposure was associated with poor kidney function, and was not related to a prolonged survival.
Tumor-intrinsic CD47 signal regulates glycolysis and promotes colorectal cancer cell growth and metastasis
Authors: Tuo Hu, Huashan Liu, Zhenxing Liang, Fengwei Wang, Chi Zhou, Xiaobin Zheng, Yunfeng Zhang, Yiwen Song, Jiancong Hu, Xiaowen He, Jian Xiao, Ryan J. King, Xianrui Wu, Ping Lan
Journal: Theranostics (2020)

Rationale: CD47 plays a vital role in the immune escape of tumor cells, but its role in regulating immune-unrelated biological processes such as proliferation and metastasis remains unclear. We seek to explore the immune-independent functions of CD47 in colorectal cancer (CRC). Methods: The expression of CD47 in CRC was determined by immunohistochemistry. The biological effect of CD47 signaling on tumor cell proliferation and metastasis was evaluated in vitro and in vivo. RNA sequencing analysis was performed to identify pivotal signaling pathways modulated by CD47. The interaction between CD47 and ENO1 was verified by co-immunoprecipitation (co-IP). The effect of CD47 on glycolytic metabolites was analyzed by seahorse XF and targeted metabolomics. Results: The expression of CD47 was upregulated and correlated to poor prognosis in CRC patients. Functional assays revealed that CD47 promoted CRC cell growth and metastasis in vitro and in vivo. Our mechanistic investigations demonstrated that CD47 interacted with ENO1 and protected it from ubiquitin-mediated degradation, subsequently promoting glycolytic activity and phosphorylation of ERK in CRC cells. Inhibition of ENO1 diminished CD47-mediated cell growth and migration. Clinically, the combined expression of CD47 and ENO1 provided reliable predictive biomarkers for the prognosis of CRC patients. Conclusions: CD47 is overexpressed in CRC, and its expression is associated with poor prognosis. Through stabilizing ENO1, CD47 enhances the aerobic glycolysis and ERK activity in CRC cells, thereby promoting the progression of CRC. Our studies reveal an unconventional role of CD47, suggesting that targeting the CD47-ENO1 axis may provide a novel therapeutic avenue for CRC.
Time Kinetics of Viral Clearance and Resolution of Symptoms in Novel Coronavirus Infection
Authors: De Chang, Guoxin Mo, Xin Yuan, Yi Tao, Xiaohua Peng, Fu-Sheng Wang, Lixin Xie, Lokesh Sharma, Charles S. Dela Cruz, Enqiang Qin
Journal: American Journal of Respiratory and Critical Care Medicine (2020)
Ideas for Next-Generation Treatments of Adolescent Obesity
Authors: Leonard H. Epstein, Teresa Quattrin
Journal: JAMA Pediatrics (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
ASSESSING THE TEMPORAL COURSE OF NEOINTIMAL HYPERPLASIA FORMATION AFTER DIFFERENT GENERATIONS OF DRUG-ELUTING STENTS
Authors: Carlos A. Collet, Jose R. Costa, Daniel Chamié, Amanda Sousa, Rodolfo Staico, Dimytri Siqueira, Javier Obregon, Ricardo A. Costa, Alexandre Abizaid, Jose E. Sousa
Journal: Journal of the American College of Cardiology (2011)
TCT-725 Changes in left atrial appendage dimensions following volume loading during percutaneous left atrial appendage closure
Authors: Ryan J. Spencer, Michael Y. Tsang, Jacqueline Saw, Peter Fahmy, Ken Gin, John Jue, Teresa S. Tsang, Peggy M. DeJong, Parvathy Nair, P.K. Lee, Mathieu Lempereur
Journal: Journal of the American College of Cardiology (2015)
Covid-19: What is the UK’s testing strategy?
Authors: Gareth Iacobucci
Journal: BMJ (2020)

The NHS is using polymerase chain reaction (PCR) testing to determine which people currently have covid-19. This involves extracting RNA from a nose or throat swab sample through laboratory analysis. It has a high level of accuracy, and results take around a day to come through. But once a person has recovered the test can no longer tell if they have been infected. The other type of test, which Public Health England (PHE) says could be available to UK residents to use at home “within days,” subject to testing, detects antibodies in the blood. This test is designed to detect whether someone previously had the virus. Blood or plasma samples are inserted into a small plastic cassette-shaped device, and results are typically ready within 10 minutes. Aside from the speed of obtaining results, the UK’s chief scientific adviser, Patrick Vallance, said that antibody tests had the advantage of being able to detect infection in people without symptoms. But the tests are less sensitive and specific than PCR tests, so can produce more false positives and false negatives.

Patients in hospital intensive care units with suspected covid-19 have been first priority, followed by people with severe respiratory illness such as pneumonia. The next priority has been isolated cluster outbreaks, …
Smoking prevalence in the area of responsibility of the German Ministry of Defense — results of the employee survey in the context of occupational health management
Authors: Stefan Sammito, Annika Claus, Dirk-Matthias Rose
Journal: Military Medical Research (2020)

Tobacco use, correlated with reduced physical fitness, is one of the leading causes of avoidable death worldwide. It increases the risk of dementia and can shorten the lifespan by 10 years. For the German Armed Forces (Bundeswehr), figures on smoking behavior have not been comprehensively captured. This study analyzes current data in a large sample from this population.Based on an employee survey as part of the Occupational Health Management System, data on smoking behavior from 13,326 participants were analyzed in relation to age, gender, professional status, education level and membership in military operational units versus other agencies.Smoking behavior varied significantly (P < 0.001) by age group (younger > older), gender, professional status, military agency membership status, and education level (the lower the education level, the higher the smoking rates). With the exception of the downward trend in smoking behavior with increasing age among civilian employees, these results were all significant (P < 0.005).This data analysis shows that smoking prevalence among personnel in the area of responsibility of the Federal Ministry of Defense is comparable to the current data from corresponding surveys of the German population. Depending on gender, they generally show values that are slightly above those of the German population. The well-known trend in the general population of decreasing smoking prevalence with increasing age is also seen in this analysis. However, there are considerable differences in the smoking prevalence among individual subgroups (professional status, agency, gender, education level). The data show that particular young soldiers in the armed forces should be the target group for further preventive measures.
Melflufen plus dexamethasone in relapsed and refractory multiple myeloma (O-12-M1): a multicentre, international, open-label, phase 1–2 study
Authors: Paul G Richardson, Sara Bringhen, Peter Voorhees, Torben Plesner, Ulf-Henrik Mellqvist, Brandi Reeves, Claudia Paba-Prada, Hanan Zubair, Catriona Byrne, Dharminder Chauhan, Kenneth Anderson, Eva Nordström, Johan Harmenberg, Antonio Palumbo, Pieter Sonneveld
Journal: The Lancet Haematology (2020)
<i>Helicobacter pylori</i>eradication therapy to prevent gastric cancer: systematic review and meta-analysis
Authors: Alexander Charles Ford, Yuhong Yuan, Paul Moayyedi
Journal: Gut (2020)

Objectives Gastric cancer is strongly associated with Helicobacter pylori ( H. pylori ). We conducted a previous systematic review and meta-analysis that suggested eradication therapy reduced future incidence of gastric cancer, but effect size was uncertain, and there was no reduction in gastric cancer-related mortality. We updated this meta-analysis, as more data has accumulated. We also evaluated impact of eradication therapy on future risk of gastric cancer in patients having endoscopic mucosal resection for gastric neoplasia. Design We searched the medical literature through February 2020 to identify randomised controlled trials (RCTs) examining effect of eradication therapy on subsequent occurrence of gastric cancer in healthy H. pylori -positive adults, and in H. pylori -positive patients with gastric neoplasia undergoing endoscopic mucosal resection. The control arm received placebo or no treatment. Follow-up was for ≥2 years. We estimated the relative risk (RR) number needed to treat (NNT), and evaluated the disability-adjusted life-years (DALYs) gained from screening from the meta-analysis. Results We identified 10 RCTs, seven recruited 8323 healthy individuals, and three randomised 1841 patients with gastric neoplasia. In healthy individuals, eradication therapy reduced incidence of gastric cancer (RR=0.54; 95% CI 0.40 to 0.72, NNT=72), and reduced mortality from gastric cancer (RR=0.61; 95% CI 0.40 to 0.92, NNT=135), but did not affect all-cause mortality. These data suggest that 8 743 815 DALYs (95% CI 5 646 173 to 11 847 456) would be gained if population screening and treatment was implemented globally. In patients with gastric neoplasia, eradication therapy also reduced incidence of future gastric cancer (RR=0.49; 95% CI 0.34 to 0.70, NNT=21). Adverse events were incompletely reported. Conclusion There is moderate evidence to suggest that H. pylori eradication therapy reduces the incidence of gastric cancer in healthy individuals and patients with gastric neoplasia in East Asian countries. There also appears to be a reduction in gastric cancer-related mortality.
Covid-19: European drugs agency to review safety of ibuprofen
Authors: Michael Day
Journal: BMJ (2020)

White matter abnormalities in the CNS have been reported recently in various neurological and psychiatric disorders. Quantitation of non-Gaussianity for water diffusion by <i>q</i>-space diffusional MRI (QSI) renders biological diffusion barriers such as myelin sheaths; however, the time-consuming nature of this method hinders its clinical application. In the current study, we aimed to refine QSI protocols to enable their clinical application and to visualize myelin signals in a clinical setting. For this purpose, animal studies were first performed to optimize the acquisition protocol of a non-Gaussian QSI metric. The heat map of standardized kurtosis values derived from optimal QSI (myelin map) was then created. Histological validation of the myelin map was performed in myelin-deficient mice and in a nonhuman primate by monitoring its variation during demyelination and remyelination after chemical spinal cord injury. The results demonstrated that it was sensitive enough to depict dysmyelination, demyelination, and remyelination in animal models. Finally, its utility in clinical practice was assessed by a pilot clinical study in a selected group of patients with multiple sclerosis (MS). The human myelin map could be obtained within 10 min with a 3 T MR scanner. Use of the myelin map was practical for visualizing white matter and it sensitively detected reappearance of myelin signals after demyelination, possibly reflecting remyelination in MS patients. Our results together suggest that the myelin map, a kurtosis-related heat map obtainable with time-saving QSI, may be a novel and clinically useful means of visualizing myelin in the human CNS. <b>SIGNIFICANCE STATEMENT</b> Myelin abnormalities in the CNS have been gaining increasing attention in various neurological and psychiatric diseases. However, appropriate methods with which to monitor CNS myelin in daily clinical practice have been lacking. In the current study, we introduced a novel MRI modality that produces the “myelin map.” The myelin map accurately depicted myelin status in mice and nonhuman primates and in a pilot clinical study of multiple sclerosis patients, suggesting that it is useful in detecting possibly remyelinated lesions. A myelin map of the human brain could be obtained in &lt;10 min using a 3 T scanner and it therefore promises to be a powerful tool for researchers and clinicians examining myelin-related diseases.