tbuckley/cabot-search huggingface dataset:
CBMT-14. THE DIELECTRIC PROPERTIES OF BRAIN TUMOR TISSUE
Authors: Martin Proescholdt, Amer Haj, Christian Doenitz, Alexander Brawanski, Ze’ev Bomzon, Hadas Sara Hershkovich
Journal: Neuro-Oncology (2019)

Abstract INTRODUCTION Recently, tumor treating fields (TTFields) were established for the treatment of newly diagnosed GBM. One of the most crucial parameters defining the treatment efficacy of TTFields is the electric field intensity, which depends on the dielectric properties of the tumor tissue. In this study we determined the dielectric properties of brain tumors by analyzing resected tissue following a fast acquisition protocol. To account for the intratumoral heterogeneity, different regions of the tumor were analyzed separately. METHODS A cohort of 84 patients with tumors of different histology have been recruited. Tissue probes were acquired from the vital tumor area and perinecrotic compartment. The tissue was measured immediately to avoid artifacts. A fragment was dissected from each tissue sample and was placed into a cylindrical cell with a known diameter. The impedance was recorded at frequencies 20Hz-1MHz using a software specifically developed for this study, which controls the LCR meter. The measured impedance was translated into dielectric properties of the sample (conductivity and relative permittivity) based on the parallel plate model, the recorded complex impedance and the geometry of the samples. Each tissue probe was fixed, H&amp;E stained and histologically analyzed. RESULTS We found significant differences between the conductivity of different types of tumors with meningiomas showing the lowest conductivity (mean conductivity [S/m]: 0.193; range: 0.327 – 0.113) and GBM tissue exhibiting the highest conductivity values (mean conductivity [S/m]: 0.402; range: 0.893 – 0.157). Consistently, the perinecrotic areas displayed lower conductivity values compared to the solid tumor compartments. Also, we found a significant intratumoral heterogeneity in tumors of one specific histological diagnosis. CONCLUSION The dielectric properties of intracranial tumors appear to be depending on histological class and malignancy grade and show significant intratumoral heterogeneity. These results may allow a more precise modelling of electric field intensity distribution within the tumor.
Concentric vs. eccentric remodelling in heart failure with reduced ejection fraction: clinical characteristics, pathophysiology and response to treatment
Authors: Jan F. Nauta, Yoran M. Hummel, Jasper Tromp, Wouter Ouwerkerk, Peter van der Meer, Xuanyi Jin, Carolyn S.P. Lam, Jeroen J. Bax, Marco Metra, Nilesh J. Samani, Piotr Ponikowski, Kenneth Dickstein, Stefan D. Anker, Chim C. Lang, Leong L. Ng, Faiez Zannad, Gerasimos S. Filippatos, Dirk J. van Veldhuisen, Joost P. van Melle, Adriaan A. Voors
Journal: European Journal of Heart Failure (2019)

Heart failure is traditionally classified by left ventricular ejection fraction (LVEF), rather than by left ventricular (LV) geometry, with guideline-recommended therapies in heart failure with reduced ejection fraction (HFrEF) but not heart failure with preserved ejection fraction (HFpEF). Most patients with HFrEF have eccentric LV hypertrophy, but some have concentric LV hypertrophy. We aimed to compare clinical characteristics, biomarker patterns, and response to treatment of patients with HFrEF and eccentric vs. concentric LV hypertrophy.We performed a retrospective post-hoc analysis including 1015 patients with HFrEF (LVEF <40%) from the multinational observational BIOSTAT-CHF study. LV geometry was classified using two-dimensional echocardiography. Network analysis of 92 biomarkers was used to investigate pathophysiologic pathways. Concentric LV hypertrophy was present in 142 (14%) patients, who were on average older and more likely hypertensive compared to those with eccentric LV hypertrophy. Network analysis revealed that N-terminal pro-B-type natriuretic peptide was an important hub in eccentric hypertrophy, whereas in concentric hypertrophy, tumour necrosis factor receptor 1, urokinase plasminogen activator surface receptor, paraoxonase and P-selectin were central hubs. Up-titration of beta-blockers was associated with a mortality benefit in HFrEF with eccentric but not concentric LV hypertrophy (P-value for interaction ≤0.001). For angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, the hazard ratio for mortality was higher in concentric hypertrophy, but the interaction was not significant.Patients with HFrEF with concentric hypertrophy have a clinical and biomarker phenotype that is distinctly different from those with eccentric hypertrophy. Patients with concentric hypertrophy may not experience similar benefit from up.-titration of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers and beta-blockers compared to patients with eccentric hypertrophy.
Inflammation-triggered local drug release ameliorates colitis by inhibiting dendritic cell migration and Th1/Th17 differentiation
Authors: Shobha Regmi, Shiva Pathak, Mahesh Raj Nepal, Prakash Shrestha, Junhyeung Park, Jong Oh Kim, Chul Soon Yong, Dong-Yong Choi, Jae-Hoon Chang, Tae Cheon Jeong, Gorka Orive, Simmyung Yook, Jee-Heon Jeong
Journal: Journal of Controlled Release (2019)
Characteristics and Outcomes of Patients Who Did Not Develop CRS after Axicabtagene Ciloleucel for Relapsed/Refractory Large B-Cell Lymphoma: Results from the US Lymphoma CAR-T Consortium
Authors: Miriam T. Jacobs, Michael D. Jain, Jay Y. Spiegel, Loretta J. Nastoupil, Yibo Li, Gao Feng, Matthew A. Lunning, Lazaros J Lekakis, Saurabh Dahiya, Patrick M Reagan, Olalekan O. Oluwole, Joseph P. McGuirk, Abhinav Deol, Alison R. Sehgal, Andre Goy, Brian T. Hill, Charalambos Andreadis, Javier Munoz, Julio Chavez, N. Nora Bennani, Aaron P. Rapoport, Julie M Vose, David B Miklos, Sattva S Neelapu, Armin Ghobadi, Frederick L. Locke
Journal: Blood (2019)
Prognostic Impact of Clonal Diversity in Acute Myeloid Leukemia (AML) Treated with Intensive Chemotherapy (IC)
Authors: Marco Cerrano, Marie Passet, Loic Vasseur, Pierre Hirsch, Xavier Thomas, Samuel Quentin, Justine Pasanisi, Florence Rabian, Ramy Rahmé, Etienne Lengline, Emmanuel Raffoux, Nathalie Dhedin, Marie Sebert, Odile Maarek, Anna Raimbault, Karine Celli-Lebras, Lionel Ades, Pierre Fenaux, Nicolas Boissel, Francois Delhommeau, Jean Soulier, Herve Dombret, Emmanuelle Clappier, Pierre Sujobert, Raphael Itzykson
Journal: Blood (2019)
Combination of CYC065, a Second Generation CDK2/9 Inhibitor, with Venetoclax or Standard Chemotherapies - a Novel Therapeutic Approach for Acute Myeloid Leukaemia (AML)
Authors: Wittawat Chantkran, Daniella Zheleva, Sheelagh Frame, Ya-Ching Hsieh, Mhairi Copland
Journal: Blood (2019)
Challenging the Association of Marijuana Laws With Teen Marijuana Use
Authors: Russell Kamer
Journal: JAMA Pediatrics (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
ASIC1a induces synovial inflammation via the Ca<sup>2+</sup>/NFATc3/ RANTES pathway
Authors: Yihao Zhang, Xuewen Qian, Xiaojuan Yang, Ruowen Niu, Sujing Song, Fei Zhu, Chuanjun Zhu, Xiaoqing Peng, Feihu Chen
Journal: Theranostics (2019)

Rationale: Synovial inflammation is one of the main pathological features of rheumatoid arthritis (RA) and is a key factor leading to the progression of RA. Understanding the regulatory mechanism of synovial inflammation is crucial for the treatment of RA. Acid-sensing ion channel 1a (ASIC1a) is an H+-gated cation channel that promotes the progression of RA, but the role of ASIC1a in synovial inflammation is unclear. This study aimed to investigate whether ASIC1a is involved in the synovial inflammation and explore the underlying mechanisms in vitro and in vivo. Methods: The expression of ASIC1a and nuclear factor of activated T cells (NFATs) were analyzed by Western blotting, immunofluorescence, and immunohistochemistry both in vitro and in vivo. The Ca2+ influx mediated by ASIC1a was detected by calcium imaging and flow cytometry. The role of ASIC1a in inflammation was studied in rats with adjuvant-induced arthritis (AA). Inflammatory cytokine profile was analyzed by protein chip in RA synovial fibroblasts (RASF) and verified by a magnetic multi-cytokine assay and ELISA. The NFATc3-regulated RANTES (Regulated upon activation, normal T cell expressed and secreted) gene transcription was investigated by ChIP-qPCR and dual-luciferase reporter assay. Results: The expression of ASIC1a was significantly increased in human RA synovial tissues and primary human RASF as well as in ankle synovium of AA rats. Activated ASIC1a mediated Ca2+ influx to increase [Ca2+]i in RASF. The activation/overexpression of ASIC1a in RASF up-regulated the expression of inflammatory cytokines RANTES, sTNF RI, MIP-1a, IL-8, sTNF RII, and ICAM-1 among which RANTES was increased most remarkably. In vivo, ASIC1a promoted inflammation, synovial hyperplasia, articular cartilage, and bone destruction, leading to the progression of AA. Furthermore, activation of ASIC1a upregulated the nuclear translocation of NFATc3, which bound to RANTES promoter and directly regulated gene transcription to enhance RANTES expression. Conclusion: ASIC1a induces synovial inflammation, which leads to the progression of RA. Our study reveals a novel RA inflammation regulatory mechanism and indicates that ASIC1a might be a potential therapeutic target for RA.
Reconstruction of Human AML Reveals Stem Cell Origin and Therapeutic Targets for Treatment Resistant CD34-/Lo MLL-Rearranged Leukemia
Authors: Tsz Kan Fung, Bernd Zeisig, Magdalena Zarowiecki, Huacheng Luo, Chiou Tsun Tsai, Boban Stanojevic, Claire Lynn, Anskar Y.-H. Leung, Jan Zuna, Marketa Zaliova, Martin Bornhaeuser, Malte Von Bonin, Boris Lenhard, Suming Huang, Ghulam J. Mufti, Chi Wai Eric So
Journal: Blood (2019)
The Paracaspase MALT1 Acts Independently of Pre-B-Cell Receptor Signaling As a Key Factor in Leukemic Cell Survival in Precursor B-Cell Acute Lymphoblastic Leukemia
Authors: Nakhle S. Saba, Jade Meyers, Lorena Fontan, Ari Melnick, Adrian Wiestner, Patricia Lobelle-Rich, Ekaterina Kim, Jan A. Burger, Yara Mouawad, Prescott L. Deininger, Francisco Socola, Hana Safah, Erik K Flemington
Journal: Blood (2019)
Typical Medical Students
Authors: N. Malleson
Journal: BMJ (1964)

CJOUnNc L tion necessary.The one case had taken only small oral doses of ergotamine; the other was receiving subcutaneous dihydroergotamine.This report was referred to in our article' in the British Medical 7ournal four years ago.Our own report was on gangrenous ergotism in a woman of 45 who had taken only 7 tablets, each containing 1 mg.ergotamine tartrate, over three days-not for migraine.Amputation of both legs, the right thumb, and tip of right index finger had to be performed.We believe that migraine confers immunity to possible side-effects from ergotamine, and further that the route of administration is probably of little importance.In some cases side-effects may arise because of abnormal response to accepted therapeutic dosage.The smallest possible dose that will control the symptoms of migraine must be found by gradually increasing the dose with each attack-increasing from 1 mg.by 1 mg.increments, respectively, in subsequent attacks until either a satisfactory dose is thus safely found, or side-effects are too severe.Paraesthesiae, coldness, and pains in the extremities should be reported at once.-We are, etc.,
Robotic radiosurgery for severe recurrent and primary head and neck cancer
Authors: K. Kawaguchi
Journal: Journal of Clinical Oncology (2009)

e17038 Background: We considered the functional reconstruction following head and neck tumor ablation, however, it was impossible to recover completely the function against the severe postoperative status. Here we describe our aim to improve local control and to obtain organ preservation by using the non-surgical outpatient procedure the CyberKnife frameless radiosurgery (CK). Methods: Between March 2006 and January 2008, 22 patients with severe recurrent, previously treated with conventional methods, and 14 patients with primary lesions were treated with CK in the management of head and neck cancer. All the patients had biopsy confirmation of disease prior to radiation therapy; rT2 (3 patients), rT3 (8), rT4 (9), T2 (5), T3 (3), T4 (6), N1 (4), N2b (3), M1 (1), tongue (11), mandibule (11), maxilla (6), maxillary sinus (4), soft palate (2), with sq. cell ca.(34), adenoid cystic ca.(1), fibrosarcoma (1). The treatment plan was set up based on CT, MRI and PET-CT in Yokohama CyberKnife Center. CK's lightweight linear accelerator always irradiates toward the target from 120 directions with image-guided computer based on CT. Marginal Doses were 2000–4200cGy in 3–5 fractions. Curative effects were evaluated assessed by RECIST included PET. Results: 11/22 (50.0%) of the severe recurrent cases were controlled from 6 to 25 months at follow-up range. The local recurrent cases with non-lymph node metastases were excellently controlled as 10/12 (83.3%). For the primary cases, significant tumor reduction were noted at the third-month follow-up, all the 14 patients went into remission with 5 cases in CR, and 9 cases in PR. Between the 4–6 month follow-up, 4 cases were performed additional CK treatment for the recurrent lesions, however, 3 patients with T4 tongue cancer were not cured. Finally, the total control rate of the primary cases was 10/14 (71.4%), however, 8/9 (88.9%) primary cases except tongue cancer has been controlled treated by CK with chemotherapy. The cases of non-lymph node metastases were cured 8/8 (100.0%) by CK. There have been no seriously complications of treatment caused by CK except severe osteoradionecrosis of the 4 patients irradiated with maximum dose. Conclusions: It is now possible with the development of CyberKnife Radiosurgery to improve our treatments of the local control in head and neck cancer. No significant financial relationships to disclose.
The Impact of the 2011 European Leukemianet (ELN) Guidelines for Philadelphia Chromosome-Negative Classical Myeloproliferative Neoplasms on Therapeutic Phlebotomy and Hydroxyurea Use in Patients with Polycythemia Vera and Essential Thrombocythemia
Authors: Nikolai A. Podoltsev, Rong Wang, Rory M Shallis, Scott F. Huntington, Amer M. Zeidan, Steven D. Gore, Amy J Davidoff, Xiaomei Ma
Journal: Blood (2019)
Loss of METTL3 Mediated m6A RNA Modification Results in Double-Stranded RNA Induced Innate Immune Response and Hematopoietic Failure
Authors: Yimeng Gao, Radovan Vasic, Yuanbin Song, Rhea Teng, Rana Gbyli, Giulia Biancon, Raman Nelakanti, Eriko Kudo, Wei Liu, Anastasia Ardasheva, Xiaoying Fu, Xiaman Wang, Poorval Joshi, Burak Dura, Veronica Lee, Gabriella Viero, Akiko Iwasaki, Rong Fan, Andrew Xiao, Richard Flavell, Hua-Bing Li, Toma Tebaldi, Stephanie Halene
Journal: Blood (2019)
Prospective Monitoring of Peripheral Blood CD26+ Leukemia Stem Cells in Chronic Myeloid Leukemia Patients from Time of TKI Discontinuation
Authors: Monica Bocchia, Anna Sicuranza, Paola Pacelli, Patrizia Pregno, Mario Annunziata, Federica Sorà, Elisabetta Abruzzese, Monica Crugnola, Luigiana Luciano, Alessandra Iurlo, Sara Galimberti, Anna Marina Liberati, Ilaria Ferrigno, Sara Ciofini, Marzia Defina, Luca Puccetti, Donatella Raspadori
Journal: Blood (2019)
Serum Free Light Chain Assay As an Additional Tool for Defining Response and Progressive Disease in Immunoglobulin Secretory Multiple Myeloma
Authors: Paola Tacchetti, Serena Rocchi, Luca Dozza, Elena Zamagni, Isola Caratozzolo, Ilaria Rizzello, Alessio Fusco, Gabriella De Cicco, Lucia Pantani, Katia Mancuso, Carolina Terragna, Nicoletta Testoni, Pier Luigi Luigi Zinzani, Michele Cavo
Journal: Blood (2019)
QOLP-02. PRESERVING FUNCTIONS OF LANGUAGE, MOTOR, AND WORKING MEMORY BY AWAKE MAPPING CONTRIBUTES TO MAINTAIN QUALITY OF LIFE IN GLIOMAS
Authors: Riho Nakajima, Masashi Kinoshita, Hirokazu Okita, Mitsutoshi Nakada
Journal: Neuro-Oncology (2019)

Abstract INTRODUCTION Aims of awake surgery are considered as maximum resection and functional preservation for postoperative quality of life (QOL). However, any studies have not been focused on the fundamental hypothesis that preservation of brain functions contributes to patient’s QOL. In this study, we investigated postoperative QOL and its related factors to reveal contribution of awake surgery for maintaining QOL. METHODS A total of 63 patients who underwent awake surgery were studied. Several kinds of neuropsychological/neurological tests and SF-36 to assess QOL were performed at 6-month postoperatively. In SF-36, 3-component scores, including physical, mental, and role/social component were calculated and they were compared with healthy volunteers. Additionally, their background factors were collected from medical records. Then, influenced background and functional factors to QOL were analyzed using multiple regression analysis. Moreover, voxel-based lesion symptom (VLSM) analyses were performed to investigate relationship between resected regions and QOL. RESULTS Though physical and mental QOL scores were almost equivalent to healthy volunteers, role and social component score (RCS) were significantly declined (36.7, &lt; .0001). Using multiple regression analysis, RCS significantly related to reinstatement among several background factors (p=0.0038). Until postoperative 6 months, 71.6% returned to professional work. Moreover, RCS correlated significantly with working memory, language, and motor function among several brain functions (p=0.019, 0.0028, 0.010, respectively). In the VLSM analysis, patients who resected following regions showed significantly low RCS; the left inferior frontal and superior to middle temporal gyri which relate to language; and right supplementary motor area and cingulate cortex which are involved in motor control or working memory. CONCLUSIONS The important factors to maintain QOL are reinstatement and preserving brain functions including language, motor, and working memory. This suggests that awake surgery aiming for preserving these functions is a benefit for postoperative QOL.
Lung Cancer Incidence in Nonmetropolitan and Metropolitan Counties — United States, 2007–2016
Authors: Mary Elizabeth O’Neil, S. Jane Henley, Elizabeth A. Rohan, Taylor D. Ellington, M. Shayne Gallaway
Journal: MMWR Morbidity and Mortality Weekly Report (2019)

Lung and bronchus (lung) cancer is the leading cause of cancer death in the United States (1). In 2016, 148,869 lung cancer deaths were reported.* Most lung cancers can be attributed to modifiable exposures, such as tobacco use, secondhand smoke, radon, and asbestos (1). Exposure to lung cancer risk factors vary over time and by characteristics such as sex, age, and nonmetropolitan or metropolitan residence that might affect lung cancer rates (1,2). A recent report found that lung cancer incidence rates were higher and decreased more slowly in nonmetropolitan counties than in metropolitan counties (3). To examine whether lung cancer incidence trends among nonmetropolitan and metropolitan counties differed by age and sex, CDC analyzed data from U.S. Cancer Statistics during 2007-2016, the most recent years for which data are available. During the 10-year study period, lung cancer incidence rates were stable among females aged <35, 45-64, and ≥75 years in nonmetropolitan counties, were stable among females aged <35 years in metropolitan counties, and decreased in all other groups. Overall, among males, lung cancer incidence rates decreased from 99 to 82 per 100,000 in nonmetropolitan areas and from 83 to 63 in metropolitan areas; among females, lung cancer incidence rates decreased from 61 to 58 in nonmetropolitan areas and from 57 to 50 in metropolitan areas. A comprehensive approach to lung cancer prevention and control includes such population-based strategies as screening for tobacco dependence, promoting tobacco cessation, implementing comprehensive smoke-free laws, testing all homes for radon and using proven methods to lower high radon levels, and reducing exposure to lung carcinogens such as asbestos (1). Increasing the implementation of these strategies, particularly among persons living in nonmetropolitan counties, might help to reduce disparities in the decline of lung cancer incidence.
Self-management interventions in COPD patients with multimorbidity
Authors: Lowie E.G.W. Vanfleteren, Leonardo M. Fabbri
Journal: European Respiratory Journal (2019)

<b>Self-management interventions in patients with COPD need to address the complexity of multimorbidity and should include action plans for worsening of both COPD and common comorbidities in order to empower patients to manage their different diseases.</b>http://bit.ly/2nXSCuz
NIMG-50. DOES THE PRESENCE OF GADOLINIUM AFFECT T2 –WEIGHTED IMAGES OF GLIOMA?: IMPLICATIONS FOR MRI PROTOCOL STANDARDIZATION
Authors: Pamela Jackson, Yuxiang Zhou, Joseph Hoxworth, Kristin Swanson, Leland Hu
Journal: Neuro-Oncology (2019)

Abstract There have been increasing efforts to standardize MRI scanning protocols for both routine and clinical trial imaging of glioma. The recent BTIP guidelines propose acquisition of T2-weighted images after gadiolinium (Gd) based contrast injection and before post-contrast 3D T1-weighted (T1W) images to control timing of images after contrast administration. While Gd-contrast shortens T1W signal and appears hyperintense on magnetic resonance imaging (MRI), Gd-contrast also shortens T2W signal, which could result in unintended alternations in T2W signal intensities. This has potential implications for model-based approaches for GBM diagnosis and the differential diagnosis of other tumor types (e.g., lymphoma) that rely on T2W signal characteristics. To our knowledge, no neuroimaging studies have formally evaluated the impact of Gd contrast on T2W imaging. We acquired multi-echo T2 sequences (TE=14, 28, 41, 55, 69 ms) both prior to and after the administration of Gd for 5 patients suspected of having a brain tumor. Quantitative T2 maps were created by fitting the signal decay to a signal exponential with the Levenburg-Marqurdt algorithm. Percent difference maps were calculated to compare the quantitative T2 changes between the pre- and post-Gd T2 maps. Additionally, we performed a Wilcoxon Rank-Sum test comparing T2 values within regions of interest (ROIs) representing the tumor and normal appearing white matter (NAWM). Significant differences between the T2 values in the tumor and NAWM ROIs were seen for 4 and 3 of the patients, respectively (all p-values &lt; 0.01). Our initial data suggests that the administration of Gd contrast may affect T2 values in both the tumor and NAWM, which could impact quantitative image-based models and diagnoses in glioma. We are currently replicating these preliminary results in an expanded cohort.
A New Step in Understanding of Fanconi Patients Peripheral Stem Cell Harvesting, a Bridge to Gene Therapy
Authors: Jean-Sebastien Diana, Sandra Manceau, Thierry Leblanc, Chloé Couzin, Alessandra Magnani, Elisa Magrin, Matthieux Bendavid, Laure Joseph, Marianne Delville, Stephane Blanche, Jean Soulier, Marina Cavazzana, Francois Lefrere
Journal: Blood (2019)