tbuckley/cabot-search huggingface dataset:
Abstract 10126: Chronic Anthrax-Lethal-Toxin Causes Progressive Cardiac Depression in Mice: Insights into Cellular Mechanism
Authors: Zhi Zhang, Heng-Jie Cheng, Satoshi Masutani, Michael F Callahan, David Zhao, Dalane Kitzman, Che Ping Cheng
Journal: Circulation (2019)

Background: Anthrax, an illness recognized since antiquity, has been a subject of research for more than 140 years. However, the cause of death in anthrax still remains an enigma. Recent evidence s...
Coupling of Integrin α5 to Annexin A2 by Flow Drives Endothelial Activation
Authors: Chenghu Zhang, Ting Zhou, Zhipeng Chen, Meng Yan, Bochuan Li, Huizhen Lv, Chunjiong Wang, Song Xiang, Lei Shi, Yi Zhu, Ding Ai
Journal: Circulation Research (2020)

Atherosclerosis preferentially occurs at specific sites of the vasculature where endothelial cells (ECs) are exposed to disturbed blood flow. Translocation of integrin α5 to lipid rafts promotes integrin activation and ligation, which is critical for oscillatory shear stress (OSS)-induced EC activation. However, the underlying mechanism of OSS promoted integrin α5 lipid raft translocation has remained largely unknown.The objective of this study was to specify the mechanotransduction mechanism of OSS-induced integrin α5 translocation and subsequent EC activation.Mass spectrometry studies identified endothelial ANXA2 (annexin A2) as a potential carrier allowing integrin α5β1 to traffic in response to OSS. Interference by siRNA of AnxA2 in ECs greatly decreased OSS-induced integrin α5β1 translocation to lipid rafts, EC activation, and monocyte adhesion. Pharmacological and genetic inhibition of PTP1B (protein tyrosine phosphatase 1B) blunted OSS-induced integrin α5β1 activation, which is dependent on Piezo1-mediated calcium influx in ECs. Furthermore, ANXA2 was identified as a direct substrate of activated PTP1B by mass spectrometry. Using bioluminescence resonance energy transfer assay, PTP1B-dephosphorylated ANXA2 at Y24 was found to lead to conformational freedom of the C-terminal core domain from the N-terminal domain of ANXA2. Immunoprecipitation assays showed that this unmasked ANXA2-C-terminal core domain specifically binds to an integrin α5 nonconserved cytoplasmic domain but not β1. Importantly, ectopic lentiviral overexpression of an ANXA2Y24F mutant increased and shRNA against Ptp1B decreased integrin α5β1 ligation, inflammatory signaling, and progression of plaques at atheroprone sites in apolipoprotein E (ApoE)-/- mice. However, the antiatherosclerotic effect of Ptp1B shRNA was abolished in AnxA2-/-ApoE-/- mice.Our data elucidate a novel endothelial mechanotransduction molecular mechanism linking atheroprone flow and activation of integrin α5β1, thereby identifying a class of potential therapeutic targets for atherosclerosis. Graphic Abstract: An graphic abstract is available for this article.
Cutaneous reactions in children treated with MEK inhibitors, BRAF inhibitors, or combination therapy: A multicenter study
Authors: Christina L. Boull, Samantha Gardeen, Talal Abdali, Edward Li, Jolee Potts, Nathan Rubin, Valerie M. Carlberg, Deepti Gupta, Raegan Hunt, Minnelly Luu, Sheilagh M. Maguiness, Christopher L. Moertel, Hannah Song, Karina L. Vivar, Carrie Coughlin, Jennifer T. Huang, Irene Lara-Corrales
Journal: Journal of the American Academy of Dermatology (2020)
Inhibition of IGF-IR signaling with the human monoclonal antibody A12 enhances the therapeutic effect of docetaxelin prostate cancer
Authors: Stephen R. Plymate, Jennifer Wu, Austin Odman, Robert Vessella, Dale Ludwig
Journal: Cancer Research (2005)

5037  Docetaxel therapy has been shown to be effective in prolonging life in men with androgen-independent (AI) prostate cancer. The effect is modest with an average increase in survival of 3 months. Anti-apoptotic pathways activated via the type 1 insulin-like growth factor receptor (IGF-IR) result in survival of prostate cancer cells following docetaxel therapy. Thus, inhibition of IGF-IR signaling should result in significant prolongation of tumor suppression. To test this hypothesis we implanted the human AI prostate cancer xenograft line LuCaP 35v subcutaneously in castrate SCID mice. When tumors reached ca.100mm3 volume, mice were divided into five treatment groups with 12 animals per group. Group 1 received docetaxel 10mg/kg i.p weekly x4; group 2 received docetaxel 5mg/kg i.p weekly x4; group 3 received docetaxel 10mg/kg i.p plus A12 40mg/kg i.p. weekly x 4; group 4 received docetaxel 5mg/kg i.p plus A12 40ug/kg weekly x4; and group 5 received vehicle control i.p. weekly x4. All therapy was stopped at week 4 and the animals were monitored for an additional 8 weeks. All control animals had tumor volumes of 1000mm3 by four weeks and were sacrificed according to tumor volume criteria. All four treatment groups had slower growth rates than control, p
Evidence for Environmental–Human Microbiota Transfer at a Manufacturing Facility with Novel Work-related Respiratory Disease
Authors: Benjamin G. Wu, Bianca Kapoor, Kristin J. Cummings, Marcia L. Stanton, Randall J. Nett, Kathleen Kreiss, Jerrold L. Abraham, Thomas V. Colby, Angela D. Franko, Francis H. Y. Green, Soma Sanyal, Jose C. Clemente, Zhan Gao, Maryaline Coffre, Peter Meyn, Adriana Heguy, Yonghua Li, Imran Sulaiman, Timothy C. Borbet, Sergei B. Koralov, Robert J. Tallaksen, Douglas Wendland, Vance D. Bachelder, Randy J. Boylstein, Ju-Hyeong Park, Jean M. Cox-Ganser, M. Abbas Virji, Judith A. Crawford, Nicole T. Edwards, Marc Veillette, Caroline Duchaine, Krista Warren, Sarah Lundeen, Martin J. Blaser, Leopoldo N. Segal
Journal: American Journal of Respiratory and Critical Care Medicine (2020)

Rationale: Workers' exposure to metalworking fluid (MWF) has been associated with respiratory disease.Objectives: As part of a public health investigation of a manufacturing facility, we performed a cross-sectional study using paired environmental and human sampling to evaluate the cross-pollination of microbes between the environment and the host and possible effects on lung pathology present among workers.Methods: Workplace environmental microbiota were evaluated in air and MWF samples. Human microbiota were evaluated in lung tissue samples from workers with respiratory symptoms found to have lymphocytic bronchiolitis and alveolar ductitis with B-cell follicles and emphysema, in lung tissue samples from control subjects, and in skin, nasal, and oral samples from 302 workers from different areas of the facility. In vitro effects of MWF exposure on murine B cells were assessed.Measurements and Main Results: An increased similarity of microbial composition was found between MWF samples and lung tissue samples of case workers compared with control subjects. Among workers in different locations within the facility, those that worked in the machine shop area had skin, nasal, and oral microbiota more closely related to the microbiota present in the MWF samples. Lung samples from four index cases and skin and nasal samples from workers in the machine shop area were enriched with Pseudomonas, the dominant taxa in MWF. Exposure to used MWF stimulated murine B-cell proliferation in vitro, a hallmark cell subtype found in the pathology of index cases.Conclusions: Evaluation of a manufacturing facility with a cluster of workers with respiratory disease supports cross-pollination of microbes from MWF to humans and suggests the potential for exposure to these microbes to be a health hazard.
The Hydrocortisone vs Pasireotide in Reducing Pancreatic Surgery Complications Noninferiority Trial—Reply
Authors: Ville Sallinen, Timo Tarvainen
Journal: JAMA Surgery (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
THU0031 High synovial fluid and serum il-18 levels in patients with rheumatoid and psoriatic arthritis
Authors: V Pittoni, M Bombardieri, A Spadaro, A Ossandon, FR Spinelli, E Taccari, V Riccieri, T Rinaldi, C Alessandri, G Valesini
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> IL-18 is a recently identified cytokine with a broad array of proinflammatory actions. Il-18 is expressed at sites of chronic inflammation in human autoimmune diseases and is thought to play a pathogenetic role especially in those immune-mediated diseases with a predominant Th1 cytokine profile. <h3>Objectives</h3> The aim of this study was to measure IL-18 levels in sera and synovial fluids (SF) of patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and osteoarthritis (OA). <h3>Methods</h3> Eighty-one patients were studied, of which thirty-three with RA (11M, 22F; mean age 54.7 ± 12.8 yrs), twenty-nine &nbsp;with PsA (23M, 6F; mean age 48.1 ± 14.2 yrs) and nineteen with OA (9M, 10F; mean age 63.6 ± 8.8 yrs). After centrifugation sera and SF were stored at -20°C and a sandwich enzyme-linked IL-18 immunoassay was performed. Statistical analysis was carried out using non parametric methods. <h3>Results</h3> IL-18 levels were significantly higher in SF than in sera of either RA (mean value ± SD = 6,758 ± 3,702 pg/ml vs 575 ± 1,118 pg/ml, p = &lt;1 × 10<sup>–6</sup>), PsA (4,234 ± 2,834 pg/ml vs 556 ± 634 pg/ml, p = &lt;1 × 10<sup>–5</sup>) and OA patients (1,054 ± 1,215 pg/ml vs 283 ± 542 pg/ml, p = 0,002). Serum IL-18 levels were significantly higher in RA(p &lt; 0.05) and in PsA (p &lt; 0.01) than in OA, while no significant difference between RA and PsA serum levels was found. SF IL-18 levels were significantly more increased in RA than in PsA (p &lt; 0.01) and OA (p &lt; 1 × 10<sup>–8</sup>). SF IL-18 levels in PsA were also higher than in OA (p &lt; 0.0002). <h3>Conclusion</h3> This study indicates that IL-18 levels are augmented in immune-mediated inflammatory arthropaties such as RA and PsA as against OA where degenerative mechanisms are generally associated with mild inflammation. The difference found is more striking if SF rather than sera were considered. The increased concentration of IL-18 found in SF as against sera in the three groups of patients suggests a pivotal role of this cytokine in local mechanisms of inflammation.
Long: molecular tracking of CML with bilineal inv(16) myeloid and del(9) lymphoid blast crisis and durable response to CD19-directed CAR-T therapy
Authors: Vinayak Venkataraman, Keagan S. Casey, Maristela Onozato, Paola Dal Cin, Valentina Nardi, Philip C. Amrein, Meghan K. Bergeron, Andrew M. Brunner, Amir T. Fathi, Julia E. Foster, Jenna Moran, Timothy A. Graubert, Hanno Hock, Chrisa Hunnewell, Matthew J. Frigault, Steven McAfee, Gabriela S. Hobbs
Journal: Leukemia (2020)
The prevalence of food allergy in Opisthorchis felineus infection endemic region - the EuroPrevall study
Authors: O. Fedorova, T. Yevdokimova, M. Fedotova, J. Janse, M. Yazdanbakhsh, G. Wong, I. Kummeling, P. Burney, M. Fernandez-Rivas, R. van Ree, L. Ogorodova, E.M. Kamaltynova
Journal: Allergy (2013)
化膿性関節炎,壊疽性膿皮症,座瘡および化膿性汗腺炎(PAPASH): PSTPIP1遺伝子の新規変異に関連する新たな自己炎症性症候群 | 文献情報 | J-GLOBAL 科学技術総合リンクセンター
Authors: V Marzano Angelo, Trevisan Valentina, Gattorno Marco, Ceccherini Isabella, DE Simone Clara, Crosti Carlo
Journal: JAMA Dermatology (2013)
ΔNp63-Regulated Epithelial-to-Mesenchymal Transition State Heterogeneity Confers a Leader–Follower Relationship That Drives Collective Invasion
Authors: Jill M. Westcott, Sharon Camacho, Apsra Nasir, Molly E. Huysman, Raneen Rahhal, Tuyen T. Dang, Anna T. Riegel, Rolf A. Brekken, Gray W. Pearson
Journal: Cancer Research (2020)

Abstract Defining how interactions between tumor subpopulations contribute to invasion is essential for understanding how tumors metastasize. Here, we find that the heterogeneous expression of the transcription factor ΔNp63 confers distinct proliferative and invasive epithelial-to-mesenchymal transition (EMT) states in subpopulations that establish a leader–follower relationship to collectively invade. A ΔNp63-high EMT program coupled the ability to proliferate with an IL1α- and miR-205–dependent suppression of cellular protrusions that are required to initiate collective invasion. An alternative ΔNp63-low EMT program conferred cells with the ability to initiate and lead collective invasion. However, this ΔNp63-low EMT state triggered a collateral loss of fitness. Importantly, rare growth-suppressed ΔNp63-low EMT cells influenced tumor progression by leading the invasion of proliferative ΔNp63-high EMT cells in heterogeneous primary tumors. Thus, heterogeneous activation of distinct EMT programs promotes a mode of collective invasion that overcomes cell intrinsic phenotypic deficiencies to induce the dissemination of proliferative tumor cells. Significance: These findings reveal how an interaction between cells in different EMT states confers properties that are not induced by either EMT program alone.
How mental health care should change as a consequence of the COVID-19 pandemic
Authors: Carmen Moreno, Til Wykes, Silvana Galderisi, Merete Nordentoft, Nicolas Crossley, Nev Jones, Mary Cannon, Christoph U Correll, Louise Byrne, Sarah Carr, Eric Y H Chen, Philip Gorwood, Sonia Johnson, Hilkka Kärkkäinen, John H Krystal, Jimmy Lee, Jeffrey Lieberman, Carlos López-Jaramillo, Miia Männikkö, Michael R Phillips, Hiroyuki Uchida, Eduard Vieta, Antonio Vita, Celso Arango
Journal: The Lancet Psychiatry (2020)
Head-to-Head Comparison of the Two MAO-B Radioligands, 18F-THK5351 and 11C-L-Deprenyl, to Visualize Astrogliosis in Patients With Neurological Disorders
Authors: Kenji Ishibashi, Masashi Kameyama, Yoshiharu Miura, Jun Toyohara, Kenji Ishii
Journal: Clinical Nuclear Medicine (2020)

Three patients with neurological disorders (cerebral infarction, progressive multifocal leukoencephalopathy, and multiple sclerosis) underwent F-THK5351 and C-L-deprenyl PET on the same day to visualize lesions undergoing astrogliosis by measuring MAO-B activity. BPND map and SUV image with F-THK5351 as well as Ki map, Ki/K1 map and SUV image with C-L-deprenyl were created. F-THK5351 BPND maps and SUV images clearly identified the lesions undergoing astrogliosis. C-L-deprenyl Ki/K1 maps were close to F-THK5351 images, but very noisy. Ki maps and SUV images were likely affected by the effect of blood flow. Hence, F-THK5351 is superior to C-L-deprenyl for visualizing lesions undergoing astrogliosis.
Abstract P229: Cost-Effectiveness of a US National Sugar-Sweetened Beverage Tax Using a Multi-Stakeholder Approach
Authors: Parke Wilde, Yue Huang, Stephen Sy, Shafika Abrahams-Gessel, Thiago V Jardim, Robert Paarlberg, Dariush Mozaffarian, Renata Micha, Tom A Gaziano
Journal: Circulation (2018)

Introduction: Taxes on sugar-sweetened beverage (SSB) purchases have emerged as a policy tool to lower obesity, diabetes and CVD risks. Prior cost-effectiveness analyses included SSB tax administration costs yet ignored tax payments as mere transfers from a societal perspective. Yet, tax payments could count as revenues for the government and as costs for consumers and the SSB industry. Corresponding health and economic impacts for different stakeholders, essential to guide decision-making, are not established. Aim: To estimate the health impact and cost-effectiveness of a national penny-per-ounce SSB tax from the healthcare perspective, societal perspective, and across 9 stakeholder groups: 6 consumer categories classified by insurance status (and reflecting varying SSB intake and risk factors), the government, the beverage industry, and other private sector. Methods: A validated microsimulation model (CVD PREDICT) was used to estimate CVD reductions, quality-adjusted life-years (QALYs) gained, costs, and cost-effectiveness among US adults (35+ years), evaluating both 100% and 50% price pass-through to consumers. Model inputs included dietary and demographic data from NHANES, policy effects on consumer intake and SSB-disease effects from meta-analyses, policy costs for tax administration based on the Berkeley tax, and validated healthcare costs. Findings were evaluated over a lifetime, with costs inflated to constant 2017 US dollars and outcomes discounted annually by 3%. Results: With 100% pass-through, the tax prevented 518,000 CVD events among US adults 35+ years over a lifetime and was cost-saving from a societal perspective. Lifetime discounted healthcare cost savings ($31.5bn) were 24 times as large as tax implementation costs ($1.3bn). Evaluating cost-effectiveness by stakeholder, for the 6 consumer categories, the tax was not cost saving, but incremental cost-effectiveness ratios (ICERs) each were &lt;$50,000/QALY. For the government, tax revenues and healthcare savings were positive, netting $73.7bn in savings. For the beverage industry, net costs were $0.63bn (limited to tax compliance costs). With 50% pass-through, the tax would prevent 279,000 CVD events over a lifetime and remained cost-saving from a societal perspective. Government healthcare savings were approximately half as large, while consumer ICERs all remained &lt;$50,000/QALY. For the beverage industry, tax costs were $33.64bn, much larger than with 100% pass-through, reflecting lower producer revenue per unit sold. Findings were robust to a range of sensitivity analyses. Conclusions: A national SSB tax would improve health and be cost-saving nationally, with varying health impacts and costs across major stakeholders. These novel findings are relevant and timely for policy decisions on continuing expansion of SSB taxes.
Hematology and oncology clinical care during the coronavirus disease 2019 pandemic
Authors: Manish A. Shah, M. Frances Emlen, Tsiporah Shore, Sebastian Mayer, John P. Leonard, Adriana Rossi, Peter Martin, Ellen Ritchie, Ruben Niesvizky, Raymond Pastore, Tessa Cigler, Maria De Sancho, Ronald Scheff, Koen Van Besien, Gail Roboz, David Nanus, Paula Goldstein, Lara Scrimenti, Manuel Hidalgo
Journal: CA A Cancer Journal for Clinicians (2020)

New York City has been at the epicenter of the coronavirus disease 2019 (COVID-19) pandemic that has already infected over a million people and resulted in more than 70,000 deaths as of early May 2020 in the United States alone. This rapid and enormous influx of patients into the health care system has had profound effects on all aspects of health care, including the care of patients with cancer. In this report, the authors highlight the transformation they underwent within the Division of Hematology and Medical Oncology as they prepared for the COVID-19 crisis in New York City. Under stressful and uncertain conditions, some of the many changes they enacted within their division included developing a regular line of communication among division leaders to ensure the development and implementation of a restructuring strategy, completely reconfiguring the inpatient and outpatient units, rapidly developing the ability to perform telemedicine video visits, and creating new COVID-rule-out and COVID-positive clinics for their patients. These changes allowed them to manage the storm while minimizing the disruption of important continuity of care to their patients with cancer. The authors hope that their experiences will be helpful to other oncology practices about to experience their own individual COVID-19 crises.
Hydroxychloroquine in Nonhospitalized Adults With Early COVID-19
Authors: Caleb P. Skipper, Katelyn A. Pastick, Nicole W. Engen, Ananta S. Bangdiwala, Mahsa Abassi, Sarah M. Lofgren, Darlisha A. Williams, Elizabeth C. Okafor, Matthew F. Pullen, Melanie R. Nicol, Alanna A. Nascene, Kathy H. Hullsiek, Matthew P. Cheng, Darlette Luke, Sylvain A. Lother, Lauren J. MacKenzie, Glen Drobot, Lauren E. Kelly, Ilan S. Schwartz, Ryan Zarychanski, Emily G. McDonald, Todd C. Lee, Radha Rajasingham, David R. Boulware
Journal: Annals of Internal Medicine (2020)

No effective oral therapy exists for early coronavirus disease 2019 (COVID-19).
Riociguat in systemic sclerosis: a potential for disease modification
Authors: Siddharth Jain, Varun Dhir
Journal: Annals of the Rheumatic Diseases (2020)

Riociguat in systemic sclerosis: a potential for disease modificationWe read with great interest the results of the recently published Riociguat Safety and Efficacy in Systemic Sclerosis (RISE-SSc) trial 1 and believe that additional analyses could further elucidate the role of riociguat in systemic sclerosis (SSc).First, considering the pleiotropic (antifibrotic, antiinflammatory and antiproliferative) actions of riociguat, an analysis of the radiographic findings [pattern-cellular non-specific interstitial pneumonia (NSIP), fibrotic NSIP or usual interstitial pneumonia (UIP); and the extent of fibrosis) in the subset of patients with interstitial lung disease (ILD) could provide useful preliminary information regarding the subset of SSc-ILD most likely be benefited with riociguat and the dominant mechanism behind its potential efficacy.Second, what was the change in forced vital capacity (FVC) in millilitre in the two groups?As done in the Safety and Efficacy of Nintedanib in Systemic Sclerosis (SENSCIS) trial in SSc-ILD, studying absolute change in millilitre, rather than percentage predicted FVC, could help avoid masking early signals of efficacy. 2 Third, a post hoc analysis of the effect of riociguat on swollen joints (31.4% patients), tender joints (42.1% patients), tenosynovitis and serum levels of C reactive protein could provide valuable evidence regarding the contribution of anti-inflammatory action 3 to its overall efficacy.With an already proven efficacy in SSc-pulmonary hypertension 4 and early signals of efficacy in skin tightening, ILD and prevention of digital ulceration, riociguat holds promise as a potential disease-modifying agent in the diverse manifestations of SSc.Trials in SSc-ILD, and those employing the exploratory and post hoc endpoints of RISE-SSc as primary outcomes, are much needed.
18F-FDG PET/CT in Labrune Syndrome
Authors: Marco Cuzzocrea, Luigia Florimonte, Elisa Scola, Riccardo Benti, Massimo Castellani
Journal: Clinical Nuclear Medicine (2020)

Abstract A 69-year-old woman presented with cognitive impairment related to attentive, executive, and mnemonic functions; progressive worsening of walking, speaking, writing, and reading ability; and double sphincter incontinence. Leukoencephalopathy, cystic lesions, and calcifications, suspected for Labrune syndrome, were observed at MRI and CT brain images. Generalized wave abnormalities were also visible at electroencephalogram. Functional brain imaging performed with 18 F-FDG PET/CT demonstrated a decreased glucose metabolism in impaired brain regions, in accordance with MRI findings. Genetic testing confirmed a mutation of SNORD118.