tbuckley/cabot-search huggingface dataset:
A survey on transarterial chemoembolization refractoriness and a real-world treatment pattern for hepatocellular carcinoma in Korea
Authors: Jae Seung Lee, Beom Kyung Kim, Seung Up Kim, Jun Yong Park, Sang Hoon Ahn, Jin Sil Seong, Kwang-Hyub Han, Do Young Kim
Journal: Clinical and Molecular Hepatology (2019)

Background/Aims Transarterial chemoembolization (TACE) is a standard treatment for intermediate-stage hepatocellular carcinoma (HCC), but there is much controversy about TACE refractoriness. The aim of this study was to identify trends in the actual clinical application of TACE and recognition of TACE refractoriness by Korean experts. Methods In total, 17 questionnaires on TACE refractoriness were administered to 161 clinicians via an online survey. Multiple answers were allowed for some questions. Results Most clinicians agreed that there is a need for standardization of TACE application through specific scoring systems (n=124, 77.0%). TACE refractoriness was predominantly expected by participants when recurrences were detected within 1 month (n=70, 43.5%), there were 4 to 6 tumors (n=77, 47.8%), the maximal tumor size was 3–5 cm (n=49, 30.4%), and when there was insufficient tumor necrosis despite TACE being repeated more than three times (n=78, 48.4%). Overall, sorafenib therapy (n=137) and radiotherapy (n=114) were preferred when repeated TACE was considered ineffective. Conclusions Treatment of HCC is often based on the clinical judgment of clinicians because of the heterogeneity among individuals. Experts need to continue discussions on the standardization and sub-classification of HCC treatment guidelines in Korea. Keywords: Liver neoplasms; Carcinoma, Hepatocellular; Embolization, Therapeutic; Surveys and Questionnaires
TREATMENT OF AORTODUODENAL SYNDROME (ADS) WITH EUS-GUIDED GASTROENTEROSTOMY (EUS-GE)
Authors: KDC Pham, R Flesland Havre
Journal: Endoscopy (2019)

ADS is a very rare condition characterized by nausea, vomiting, abdominal pain, malnourishment, and weight loss. ADS is caused by upper gastrointestinal obstruction due to an abdominal aorta aneurysm (AAA). Most patients are treated with open surgery with AAA repair and gastro-enteral anastomosis. EUS-GJ with lumen apposing metallic stents (LAMS) is a technique to create a fistula between the stomach and the jejunum, to relieve symptoms in case of gastric outlet obstruction. We describe the first case of ADS managed endoscopically with EUS-GE.
Vascular Teams in Peripheral Vascular Disease
Authors: Dhaval Kolte, Sahil A. Parikh, Gregory Piazza, Mehdi H. Shishehbor, Joshua A. Beckman, Christopher J. White, Michael R. Jaff, Alexander Iribarne, Tom C. Nguyen, James B. Froehlich, Kenneth Rosenfield, Herbert D. Aronow
Journal: Journal of the American College of Cardiology (2019)
Abstract 1449: Neovascularization and Left Ventricular Function after Myocardial Infarction in Rats are Improved by Transplantation of Endothelial Progenitor Cells
Authors: Alexander Schuh, Elisa A Liehn, Rebekka Schneider, Sabine Neuss, Malte Kelm, Christian Weber, Marc W Merx
Journal: Circulation (2006)

As a novel therapy for heart failure and ischemic heart disease cell transplantation has emerged as a promising future treatment. Recent reports suggest that local or systemic administration of end...
Letter to Editor: Association Between Postoperative Liver Dysfunction and Blood‐Derived MicroRNA Signatures
Authors: Haisu Dai, Kaicheng Shen, Xingxing Su, Yishi Yang, Yan Jiang, Zhiyu Chen
Journal: Hepatology (2019)

Supported by grants from the National Natural Science Foundation of China (No. 81472775 and 81874211). Potential conflict of interest: Nothing to report. To the Editor: We read with great interest the article by Starlinger et al.1 This translational study analyzed preoperative plasma microRNA (miRNA) signature levels in two cohorts (exploratory and confirmatory) of 154 patients with hepatectomy. Random forest modeling showed that two top‐ranked miRNA pairs were identified (151a‐5p/192‐5p, 122‐5p/151a‐5p) with significant preoperative differences between individuals developing liver dysfunction (LD) and controls, and multivariate logistic regression analysis revealed that two miRNA ratios were independently associated with LD after curative resection (all P < 0.01). Therefore, the author concluded that the novel miRNA‐based biomarker represents a promising prognostic factor in patients undergoing partial hepatectomy, which might be helpful in guiding surgical decisions to the specific risk profile of patients. However, we would like to raise the following points: As the authors mention, patients with and without LD were matched based on basic characteristics and liver function. However, showed in their study, albumin levels differed significantly between the two groups (39.1 [31.5‐47.3] vs. 43.2 [37.0‐46.6] g/dL; P = 0.004), suggesting that there was an unbalanced background for comparisons between the two groups. Albumin is one of the main factors in Child‐Pugh classification, and it is an important marker of synthetic function. Decreases in serum albumin concentrations lead to increased perioperative morbidity and mortality rates.2 Therefore, we highly recommend that albumin should be matched between the two groups. In addition, the number of variables on patients’ baseline characteristics in this study seemed insufficient (e.g., operative time, operative estimated blood loss,3 need for vena cava or other vascular resection,4 and blood transfusion requirement5), even though these variables have an important influence on the postoperative morbidity and mortality, as demonstrated in many studies.3 Therefore, the reliability and accuracy of the conclusions of this study need further evaluation. Furthermore, whether analyzing miRNA would cost more money and cause longer wait times or even delay treatment is another important aspect that must be considered in translational medicine. In conclusion, we deeply appreciate the authors’ work. Moreover, we suggest that the level of albumin in preoperative groups should be matched. In addition, more details on the variables of patients’ characteristics should be included in this study. Clarification about the omissions we mention would greatly solidify the conclusions of the study by Starlinger et al.1
Clinical Application of Volatile Organic Compound–Based Exhaled Breath Tests for Cancer Diagnosis—In Reply
Authors: George B. Hanna, Piers R. Boshier, Sheraz R. Markar
Journal: JAMA Oncology (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Conception d'une application mobile d'aide à la prise en charge en Hépato-Gastro-Entérologie à destination des internes en médecine: le projet «GastroHelp»
Authors: J Lazartigues, A Gangloff, M Hassine, F Di Fiore, G Savoye
Journal: Endoscopy (2019)

L'essor et la démocratisation des smartphones ont considérablement modifié la vie des professionnels de santé en facilitant l'accès au savoir. Néanmoins, les applications mobiles de santé à destination des internes en médecine d'Hépato-Gastro-Entérologie (HGE) renfermant un contenu médical synthétique, fiable et utilisable dans notre pratique quotidienne sont peu nombreuses. L'objectif est la mise en place d'un guide thérapeutique en HGE sous forme d'application mobile.
Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes
Authors: Hemraj B. Dodiya, Thomas Kuntz, Shabana M. Shaik, Caroline Baufeld, Jeffrey Leibowitz, Xulun Zhang, Neil Gottel, Xiaoqiong Zhang, Oleg Butovsky, Jack A. Gilbert, Sangram S. Sisodia
Journal: The Journal of Experimental Medicine (2019)

We demonstrated that an antibiotic cocktail (ABX)-perturbed gut microbiome is associated with reduced amyloid-β (Aβ) plaque pathology and astrogliosis in the male amyloid precursor protein (APP)SWE/presenilin 1 (PS1)ΔE9 transgenic model of Aβ amyloidosis. We now show that in an independent, aggressive APPSWE/PS1L166P (APPPS1-21) mouse model of Aβ amyloidosis, an ABX-perturbed gut microbiome is associated with a reduction in Aβ pathology and alterations in microglial morphology, thus establishing the generality of the phenomenon. Most importantly, these latter alterations occur only in brains of male mice, not in the brains of female mice. Furthermore, ABX treatment lead to alterations in levels of selected microglial expressed transcripts indicative of the “M0” homeostatic state in male but not in female mice. Finally, we found that transplants of fecal microbiota from age-matched APPPS1-21 male mice into ABX-treated APPPS1-21 male restores the gut microbiome and partially restores Aβ pathology and microglial morphology, thus demonstrating a causal role of the microbiome in the modulation of Aβ amyloidosis and microglial physiology in mouse models of Aβ amyloidosis.
Treatment outcomes after post-operative radiotherapy in triple-negative breast cancer: Multi-institutional retrospective study (KROG 17-05)
Authors: J.H. Kim, S.J. Byun, K.H. Shin, D.-Y. Kim, T.H. Kim, Y.B. Kim, S.-Y. Lee, K. Kim
Journal: Annals of Oncology (2019)

Background: Triple-negative breast cancer (TNBC) shows different clinical course from ER-positive cancers. We designed multi-institutional retrospective study to analyze treatment outcomes after post-operative radiotherapy in TNBC. Methods: We retrospectively reviewed 699 TNBC patients with post-operative radiation therapy from 6 institutions between 2008 and 2010. Median age was 49 (range, 24-80) and neoadjuvant chemotherapy was administered in 130 patients (18.6%). Breast conserving surgery was done in 634 (90.7%) and invasive ductal carcinoma was reported in 611 (87.4%). Two hundred and twenty five patients (36.5%) were stage I, 305 (43.6%) in II, and 67 (9.6%) in III. Lymphatic invasion (LI) was reported in 240 patients (34.3%) and extracapsular extension (ECE) was in 49 (7.0%). Patients were irradiated 45-50.4Gy with 25-28 fractions to the breast or chest wall followed by tumor bed boost with 10-16Gy with 5-8 fractions. Simultaneously, additional radiation fields were irradiated to supraclavicular or internal mammary lymph nodal areas. Adjuvant chemotherapy was done in 596 (85.3%). Results: In median 94 months (range, 7-192) after treatments, 594 patients (85.0%) were no evidence of disease, 31 patients (5.0%) with alive with disease, 3 patients (0.4%) with died due to other causes, and 67 (9.6%) death from the breast cancer. Local recurrence was reported in 33 patients (4.7%), and regional failure was in 31 patients (4.4%), respectively. Distant metastasis was in 78 patients (11.2%). 5-year OS was 91.4%, 5-year LRRFS was 92.3%, 5-year DMFS was 89.4%, 5-year DFS was 85.2%, and 5-year CSS was 91.8%. On univariate analysis, age, clinical/pathologic T stages, clinical/pathologic N stages, histologic grade, LI, and ECE were related to survival rates. On multivariate analysis, younger age (≤50), clinical/pathologic stages, and ECE were also related to the survival outcomes. Conclusions: We could verify several prognostic factors including age, stage, and ECE related survival outcomes after post-operative radiation therapy in TNBC. Distant metastasis was also more common than loco-regional failures. Further detailed analysis, including more patients scheduled for enrolment, would be necessary. Legal entity responsible for the study: Jin Hee Kim. Funding: Has not received any funding. Disclosure: All authors have declared no conflicts of interest.
RANDOMIZED STUDY SHOWS THAT SIMPLE, SPECIFIC VERBAL INSTRUCTIONS IMPROVE THE QUALITY OF BOWEL PREPARATION IN INPATIENTS UNDERGOING COLONOSCOPY
Authors: K Triantafyllou, P Gkolfakis, A Skamnelos, G Diamantopoulou, A Dagas, G Tziatzios, K Thomopoulos, S Potamianos, D Christodoulou
Journal: Endoscopy (2019)

Bowel preparation for colonoscopy is often inadequate in hospitalized patients. We aimed to explore the effect of specific verbal instructions on the quality of inpatients bowel preparation.
Neutrophilic inflammation in asthma and defective epithelial translational control
Authors: Abilash Ravi, Saheli Chowdhury, Annemiek Dijkhuis, Peter I. Bonta, Peter J. Sterk, René Lutter
Journal: European Respiratory Journal (2019)

Neutrophilic inflammation in asthma is associated with interleukin (IL)-17A, corticosteroid-insensitivity and bronchodilator-induced forced expiratory volume in 1 s (FEV1) reversibility. IL-17A synergises with tumour necrosis factor (TNF)-α in the production of the neutrophil chemokine CXCL-8 by primary bronchial epithelial cells (PBECs).We hypothesised that local neutrophilic inflammation in asthma correlates with IL-17A and TNF-α-induced CXCL-8 production by PBECs from asthma patients.PBECs from most asthma patients displayed an exaggerated CXCL-8 production in response to TNF-α and IL-17A, but not to TNF-α alone, and which was also insensitive to corticosteroids. This hyperresponsiveness of PBECs strongly correlated with CXCL-8 levels and neutrophil numbers in bronchoalveolar lavage from the corresponding patients, but not with that of eosinophils. In addition, this hyperresponsiveness also correlated with bronchodilator-induced FEV1 % reversibility. At the molecular level, epithelial hyperresponsiveness was associated with failure of the translational repressor T-cell internal antigen-1 related protein (TiAR) to translocate to the cytoplasm to halt CXCL-8 production, as confirmed by TiAR knockdown. This is in line with the finding that hyperresponsive PBECs also produced enhanced levels of other inflammatory mediators.Hyperresponsive PBECs in asthma patients may underlie neutrophilic and corticosteroid-insensitive inflammation and a reduced FEV1, irrespective of eosinophilic inflammation. Normalising cytoplasmic translocation of TiAR is a potential therapeutic target in neutrophilic, corticosteroid-insensitive asthma.
Reply to Maxine G. Tran, Ravi Barod, and Axel Bex's Letter to the Editor re: Philip S. Macklin, Mark E. Sullivan, Charles R. Tapping, et al. Tumour Seeding in the Tract of Percutaneous Renal Tumour Biopsy: A Report on Seven Cases from a UK Tertiary Referral Centre. Eur Urol 2019;75:861–7
Authors: Philip S. Macklin, Mark E. Sullivan, Charles R. Tapping, Guy M. Webster, Ian S.D. Roberts, Clare L. Verrill, Lisa Browning
Journal: European Urology (2019)
TEMPORARY EUS-GUIDED ANASTOMOSES (TEA) AS THERAPEUTIC ACCESS FISTULAS (TAF) IN BENIGN BILIARY OBSTRUCTION (BBO) NOT AMENABLE TO ERCP: EMERGING APPLICATION OF EUS-GUIDED BILIARY DRAINAGE (EUS-BD)
Authors: M De Benito, A Yaiza Carbajo, S Bazaga, FJ Garcia-Alonso, R Sanchez-Ocaña, I Peñas-Herrero, F Garcia-Pajares, C De la Serna Higuera, M Perez-Miranda
Journal: Endoscopy (2019)

Transpapillary EUS-BD is gaining acceptance in BBO. The potential of transmural EUS-BD in complex BBO warrants study. To assess feasibility and efficacy of TEA using transmural covered self-expandable metal-stents (cSEMS) to provide interval biliary drainage and create TAF for biliary endotherapy under cholangioscopy/fluoroscopy in BBO not amenable to ERCP.
Adjuvant capecitabine for invasive lobular/mixed early breast cancer (EBC): USON 01062 exploratory analyses.
Authors: Joyce O'Shaughnessy, John E. Pippen, Devchand Paul, Christopher T. Stokoe, Joanne Lorraine Blum, Lea Krekow, Frankie Ann Holmes, Christine Lopez-Diaz, Svetislava J. Vukelja, Deborah Lindquist, Scot M. Sedlacek, Ragene Ruth Rivera, Robert J. Brooks, Kristi McIntyre, Yunfei Wang
Journal: Journal of Clinical Oncology (2012)

547 Background: Randomized phase III USON 01062 trial determining if patients with EBC would benefit from addition of capecitabine to docetaxel after AC (AC-T vs AC-XT). AC-T: docetaxel 100mg/M 2 IV; AC-XT: docetaxel 75mg/M 2 IV with capecitabine 825mg/M 2 PO BID 14/7 days every 21days for 4 cycles. The primary endpoint, improvement in disease-free survival (DFS) at 5 years, was not met (HR=0.84, p=0.12) likely due to lower-than-expected event rate. The secondary endpoint, overall survival (OS), was improved with capecitabine (HR 0.68, p=0.01) (O’Shaughnessy, J. ASCO, 2011). Methods: Molecular analyses demonstrate that pleomorphic lobular (mixed lobular/ductal) carcinomas evolve from the same precursor and/or through the same genetic pathway as classical lobular cancers (Reis-Filho, J., J Path, 2005). We conducted exploratory analyses to evaluate the addition of adjuvant capecitabine in ductal vs lobular or lobular/ductal (mixed) EBC within USON 01062. Histology was classified according to local pathology assessment on patients’ primary cancers. Results: In ductal patients (n=2195), there was no difference in DFS (HR=0.92, p=0.48) and OS (HR=0.75, p=0.07) with AC-T vs AC-XT. In lobular/mixed patients (n=355), adding capecitabine improved DFS (HR=0.55, p=0.055) and OS (HR=0.38, p=0.04). There was no difference in DFS (HR=1.004, p=0.98) in the ER+ ductal patients (n=1258) with the addition of capecitabine. Conclusions: Ductal and lobular cancers have distinct histologic and molecular characteristics; lobular cancers are generally less sensitive to chemotherapy (Cristofanilli, M. JCO, 2005). This exploratory analysis suggests that patients with lobular/mixed EBC may benefit from adjuvant capecitabine. This hypothesis requires evaluation in other adjuvant capecitabine trials. [Table: see text]
Increased Incidence of Autoimmune and Infectious Diseases Among a Large Group of Diffuse Large B-Cell Lymphoma (DLBCL) Survivors: A Population-Based Study
Authors: Tanaya Shree, Qian Li, Sally L. Glaser, Holden T. Maecker, Robert W. Haile, Ronald Levy, Theresa H.M. Keegan
Journal: Blood (2017)
Abstract 12: Whole Blood DNA Methylation Signatures of a Mediterranean-style Dietary Pattern
Authors: Jiantao Ma, Chunyu Liu, Roby Joehanes, Michael M Mendelson, Liming Liang, Alice H Lichtenstein, Frank B Hu, Daniel Levy
Journal: Circulation (2017)

Introduction: Mediterranean-style dietary patterns (MSDPs) have been associated with lower risk of cardiometabolic diseases, but the underlying biological mechanisms are poorly understood. To date, little is known in humans of the relationship between MSDPs and epigenetics. We hypothesized that adherence to a MSDP is associated with DNA methylation, an important epigenetic modification. Methods: We conducted a cross-sectional study of 3,563 Framingham Heart Study participants (median age 59 years, 55% women). We excluded participants with heavy alcohol use. Whole-blood derived DNA methylation of 480,000 cytosine-phosphate-guanine dinucleotides (CpGs) was assessed using the Illumina HumanMethylation450 BeadChip. A MSDP score was created based on nine dietary components, including fruits, vegetables, legumes, nuts, whole grains, fish, red meat, alcohol, and ratio of monounsaturated fatty acids to saturated fatty acids. Food intake was assessed by a validated food frequency questionnaire. Our study sample was randomly split into separate discovery/replication groups (n=1,788 and n=1,775) by pedigrees. We tested the association of CpG methylation with the MSDP score using linear mixed model, adjusted for sex, age, and energy intake (as well as family structure, imputed leukocyte composition, and technical variables). CpGs identified in discovery at FDR&lt;0.05 were taken forward for replication. We then tested the significance (Bonferroni corrected α 0.05) of the identified CpGs after additional adjustment for smoking, physical activity, and BMI in whole study sample. Results: One CpG, cg05575921 in the AHRR gene, was associated with MSDP score in the discovery sample ( P =3.3x10 -10 ) and replicated in the replication sample ( P =3.6x10 -5 ). In whole study sample, higher MSDP score was associated with greater methylation of cg05575921 after adjustment for sex, age, energy intake, smoking, physical activity, and BMI ( P =4.5x10 -3 ). Higher fruit and whole grain intake was also associated with higher methylation level of cg05575921 ( P =3.8x10 -7 and 5.1x10 -8 , respectively) and legume intake was associated with higher methylation level of cg17333223 (annotated to the NSA2 gene, P =1.3x10 -7 ). In contrast, fruit intake was associated with lower methylation of cg07035242 (annotated to the UBIAD1 gene, P =2.0x10 -7 ). These patterns persisted in the replication and in whole study sample. Conclusions: These data demonstrate a unique whole blood DNA methylation signature of a MSDP score and some of its individual components. The differentially methylated genes may represent therapeutic targets for prevention or treatment of cardiometabolic diseases. Future work is needed to explore the underlying mechanisms.
Targeting Peripheral CB1 Receptors Reduces Ethanol Intake via a Gut-Brain Axis
Authors: Grzegorz Godlewski, Resat Cinar, Nathan J. Coffey, Jie Liu, Tony Jourdan, Bani Mukhopadhyay, Lee Chedester, Ziyi Liu, Douglas Osei-Hyiaman, Malliga R. Iyer, Joshua K. Park, Roy G. Smith, Hiroshi Iwakura, George Kunos
Journal: Cell Metabolism (2019)
Phosphatase 1 Nuclear Targeting Subunit, a Novel DNA Repair Partner of PARP1
Authors: Junko Murai, Yves Pommier
Journal: Cancer Research (2019)

Abstract There is extensive literature on PARP1, owing to the multiple functions of PARP1 for DNA repair, aging, chromatin remodeling and transcription, and to the successful clinical development of four PARP inhibitors. In this issue of Cancer Research, Wang and colleagues identified phosphatase 1 nuclear targeting subunit (PNUTS, also referred to as PP1R10) as a partner of PARP1 and demonstrated that PNUTS and PARP1 are interdependent for their recruitment to DNA damage sites. As PARP1 is a prominent target for cancer therapy and PNUTS has PARP-dependent as well as PARP1-independent activities, the findings of Wang and colleagues add insight into DNA repair mechanisms with potential application to drug targeting and precision therapy. See related article by Wang et al., p. 2526
Heart Failure With Preserved Ejection Fraction In Perspective
Authors: Marc A. Pfeffer, Amil M. Shah, Barry A. Borlaug
Journal: Circulation Research (2019)

Approximately half of the patients with signs and symptoms of heart failure have a left ventricular ejection fraction that is not markedly abnormal. Despite the historically initial surprise, heightened risks for heart failure specific major adverse events occur across the broad range of ejection fraction, including normal. The recognition of the magnitude of the problem of heart failure with preserved ejection fraction in the past 20 years has spurred an explosion of clinical investigation and growing intensity of informative outcome trials. This article addresses the historic development of this component of the heart failure syndrome, including the epidemiology, pathophysiology, and existing and planned therapeutic studies. Looking forward, more specific phenotyping and even genotyping of subpopulations should lead to improvements in outcomes from future trials.