tbuckley/cabot-search huggingface dataset:
Role of Spleen Tyrosine Kinase Signaling in Early B Cell Acute Lymphoblastic Leukemia.
Authors: Tatiana Perova, Lauryl Nutter, Irina Matei, Ildiko Grandal, Polly Pine, Yasumichi Hitoshi, Johann K. Hitzler, Cynthia J Guidos, Jayne S Danska
Journal: Blood (2009)
Allo-HSCT from MUD/MRD As a Curative Treatment in Paroxysmal Nocturnal Hemoglobinuria
Authors: Miroslaw Markiewicz, Anna Koclega, Monika Dzierzak-Mietla, Patrycja Zielinska, Ewa Mendek-Czajkowska, Krzysztof Bialas, Slawomira Kyrcz-Krzemien
Journal: Blood (2014)
Hydroxyurea Is Associated with Early Onset Malaria Episode in Treated Sickle Cell Disease Patients
Authors: Aldiouma Guindo, Yeya dit Sadio Sarro, Boubacari Ali Toure, Baba Fane, Mody Coulibaly, Oumahane Ouane Diallo, Alain Dorie, Dapa Aly Diallo
Journal: Blood (2016)
Single Unit Cord Blood Transplant Supported by Third Party Highly Purified Mobilized Hematopoietic Stem Cells: Immune Reconstitution Studies.
Authors: Elena Magro, Rosa Gonzalo-Daganzo, Trinidad Martin-Donaire, Rocio Sanchez, Nuria Panadero, Rafael Cabrera, Carmen Regidor, Jose A. Garcia-Marco, Rafael Fores, Isabel Krsnik, Elena Ruiz, Guiomar Bautista, Emilio Ojeda, Isabel Sanjuan, Carlos Vallejo, Isabel Millan, Adria Prieto, Paul Travers, Alejandro Madrigal, Manuel Fernandez
Journal: Blood (2006)
Anti-Xa Levels and Renal Function: Analysis of the First 32 Patients in the Tinzaparin in Renal Insufficiency for Venous Thromboembolism Study.
Authors: Wendy Lim, James Douketis, Luqi Wang, Karen Woods, Terri Schnurr, Krystyna Kinnon, Rebecca Cruickshank, Catherine M. Clase, Christian Rabbat, Mark A. Crowther
Journal: Blood (2005)
Efficacy of Autologous Stem-Cell Transplantation in Patients with Relapsed or Refractory Aggressive B-Cell Lymphoma in the Rituximab Era. A Multicenter Geltamo Study.
Authors: Alba María Redondo, Alejandro Martín, Helena Pomares, María Jesús Vidal, María Jesús Pascual, Beatriz Quereda, Juan Manuel Sancho, Joaquín Díaz-Mediavilla, Javier López, Eulogio Conde, Isidro Jarque, Natalia Alonso, María José Ramirez, María José Sayas, María José Requena, Antonio Salar, José David González, Eva González-Barca, Reyes Arranz, Jesús F San Miguel, Dolores Caballero
Journal: Blood (2012)
Cytochrome b5 Reductase T116S Mutation and Hemolysis in Sickle Cell Disease.
Authors: Mehdi Nouraie, Noel S. Reading, Andrew Campbell, Caterina Minniti, Sohail R Rana, Lori Luchtman-Jones, Craig Sable, Niti Dham, Gregory Ensing, Gregory J Kato, Mark Gladwin, Oswaldo L Castro, Josef T. Prchal, Victor R. Gordeuk
Journal: Blood (2009)
Successful Delivery of Patients with FXIII Deficiency on Prophylaxis in Iran
Authors: Majid Naderi, Peyman Eshghi, Nader Cohan, Minoo Yaghmaei, Ebrahim Miri Moghaddam, Simin Sadeghi-Bojd, Mehran Karimi, Hamid Hoorfar, Manijeh Lak, Behzad Narouie
Journal: Blood (2011)
Durable Remissions with the VcR-CVAD Regimen for Mantle Cell Lymphoma (MCL), Regardless of Age: Long-Term Follow-up of a Wisconsin Oncology Network (WON) Study
Authors: Julie E. Chang, Christopher Peterson, Lakeesha L. Carmichael, KyungMann Kim, David T. Yang, Anne M. Traynor, Jae E. Werndli, Michael Huie, Thomas McFarland, Michael Volk, Jules H. Blank, Natalie S. Callander, Walter L. Longo, Brad S. Kahl
Journal: Blood (2016)
NS-018, a Selective JAK2V617F Inhibitor, Improves JAK2V617F-Induced Murine Myelofibrosis Without Decreasing The Erythrocyte Or Platelet Count
Authors: Yohei Nakaya, Kotaro Shide, Haruna Naito, Tomoko Niwa, Tatsuya Horio, Jun Miyake, Kazuya Shimoda
Journal: Blood (2013)
Ex Vivo Multiplexed Signal Pathway Inhibitor Treatment Reveals Differential Sensitivity of Myeloma and Non-Myeloma Bone Marrow Cell Populations.
Authors: Virginia Espina, Alessandra Romano, Amy VanMeter, Gregory Orloff, Alexander I. Spira, Dipti Patel, Christopher Walker, Emanuel F Petricoin, Lance A Liotta
Journal: Blood (2009)
Rituximab Reduces Anti-UL94 and Anti-NAG-2 Antibodies Titer and Is Effective against Skin-Chronic Graft Versus Host Disease Resembling Scleroderma.
Authors: Rocco Pastano, Chiara Dell'Agnola, Caterina Bason, Federica Gigli, Cristina Rabascio, Antonio Puccetti, Gianluigi Cetto, Fedro Alessandro Peccatori, Giovanni Martinelli, Claudio Lunardi
Journal: Blood (2009)
Phase IB/II Study of Nivolumab in Combination with Azacytidine (AZA) in Patients (pts) with Relapsed Acute Myeloid Leukemia (AML)
Authors: Naval Daver, Sreyashi Basu, Guillermo Garcia-Manero, Jorge E. Cortes, Farhad Ravandi, Elias J. Jabbour, Stephany Hendrickson, Sherry Pierce, Jing Ning, Marina Konopleva, Michael Andreeff, Steven M. Kornblau, Naveen Pemmaraju, Carlos E Bueso-Ramos, Jorge Blando, Juliana Elisa Hidalgo Lopez, James Allison, Hagop M. Kantarjian, Padmanee Sharma
Journal: Blood (2016)
Incidence of Severe (≤ 10g/dl) Chronic Anemia in Elderly Patients with Newly Diagnosed Chronic Myeloid Leukemia Treated with Imatinib and Role of Erythropoietin Therapy
Authors: Laura Cesini, Ida Carmosino, Melissa Campanelli, Massimo Breccia, Maria Lucia De Luca, Gioia Colafigli, Matteo Molica, Fulvio Massaro, Federico Vozella, Daniela Diverio, Marco Mancini, Giuliana Alimena, Roberto Latagliata
Journal: Blood (2016)
Molecular Response at 3 Months On Nilotinib Therapy Predicts Response and Long-Term Outcomes in Patients with Imatinib-Resistant or -Intolerant Chronic Myeloid Leukemia in Chronic Phase (CML-CP).
Authors: Susan Branford, Dong-Wook Kim, Simona Soverini, Enrico Gottardi, Lan Beppu, Martin C Müller, Ariful Haque, Yaping Shou, Richard C. Woodman, Hagop M. Kantarjian, Giovanni Martinelli, Jerald P. Radich, Giuseppe Saglio, Timothy P. Hughes, Andreas Hochhaus
Journal: Blood (2009)
PKC412 Inhibits the ZNF198-FGFR1 Fusion Tyrosine Kinase and Is Efficacious in Treatment of t(8;13)(p11;q12) Associated Stem Cell Myeloproliferative Disease.
Authors: Jing Chen, Daniel J. DeAngelo, Jeffery L. Kutok, Ifor R. Williams, Benjamin H. Lee, Martha Wadleigh, Nicole Duclos, Sarah Cohen, Jennifer Adelsperger, Rachel Okabe, Allison Coburn, Ilene Galinsky, Brian J.P. Huntly, Pamela Cohen, Thomas Meyer, Doriano Fabbro, Lolita Banerji, James D. Griffin, Sheng Xiao, Jonathan A. Fletcher, Richard M. Stone, D. Gary Gilliland
Journal: Blood (2004)
Impact of Pegfilgrastim on Hematological Reconstitution and Incidence of Neutropenic Fever after Consolidation Therapy with High-Dose Cytarabine in Acute Myeloid Leukemia: Comparative Analysis between AMLSG 07-04 and the German AML Intergroup Trial.
Authors: Richard F. Schlenk, Konstanze Dohner, Silia Groner, Peer C. Hartmann, Jürgen Krauter, Arnold Ganser, Hartmut Dohner
Journal: Blood (2006)
Gene Modification of Human Primary Natural Killer Cells by Electroporation with mRNA or DNA Coding for An Anti-GD2 Chimeric Antigen Receptor.
Authors: Srinivas S. Somanchi, Cecele J Denman, Atharva Amritkar, Vladimir Senyukov, Simon Olivares, Laurence J.N Cooper, Dean A. Lee
Journal: Blood (2009)
An Analysis of CNS2 Patients with AML: Do They Require Additional Intrathecal Therapy? a Report from Children’s Oncology Group Protocols AAML0531 and 03P1 and St Jude Children’s Research Hospital Protocol AML02
Authors: Donna Johnston, Jeffrey E Rubnitz, Todd A. Alonzo, Robert B. Gerbing, Richard Aplenc, Alan S. Gamis, Soheil Meshinchi
Journal: Blood (2014)
Hydroxyurea Effectiveness in Children and Adolescents with Sickle Cell Anemia: A Large Retrospective, Population-Based Cohort Study
Authors: Maa-Ohui Quarmyne, Wei Dong, Vaughn Barry, Rodney Theodore, Olufolake A. Adisa, Iris Buchanan, James Bost, Robert Clark Brown, Clinton H. Joiner, Peter A. Lane
Journal: Blood (2015)
Coordinated Regulation of Hematopoietic and Mesenchymal Stem Cells in a Bone Marrow Niche.
Authors: Simón Méndez-Ferrer, Tatyana V. Michurina, Francesca Ferraro, Amin Mazloom, Ben MacArthur, Sergio Lira, David T. Scadden, Avi Ma'ayan, Grigori N. Enikolopov, Paul S. Frenette
Journal: Blood (2009)
The Hospital Readmissions Reduction Program
Authors: Mitchell A. Psotka, Gregg C. Fonarow, Larry A. Allen, Karen E. Joynt Maddox, Mona Fiuzat, Paul Heidenreich, Adrian F. Hernandez, Marvin A. Konstam, Clyde W. Yancy, Christopher M. O'Connor
Journal: JACC Heart Failure (2019)
A Phase 2, Double-Blind, Placebo-Controlled Trial of Rituximab + Galiximab Vs Rituximab + Placebo In Advanced Follicular Non-Hodgkin's Lymphoma (NHL)
Authors: Isabelle Bence-Bruckler, David Macdonald, Patrick J Stiff, Byron McKinney, Katherine L. Ruffner, Lynn Wilson, Margaret Whiteley, Brad Kahl
Journal: Blood (2010)
Improved Strategy for Rapid Generation of Quadrivirus-Specific CD8+ and CD4+ Cytotoxic T Lymphocytes (CTLs) for Adoptive Transfer After Stem Cell Transplantation (SCT)
Authors: Alexandros Spyridonidis, Pawel Muranski, Sid Kerkar, Kazushi Tanimoto, Nancy F. Hensel, J. Joseph Melenhorst, A. John Barrett
Journal: Blood (2012)
Whole Genome Association Study in Leukemia: Frequent Loss of Heterozygosity (LOH) and Single Nucleotide Polymorphism (SNP) in Acute Myeloid Leukemia with a Normal Karyotype.
Authors: Young Y. Lee, Joowon Park, Sung-Soo Yoon, Kwang-Sung Ahn, Jung H. Choi, Byoung B. Park, Byoung K. Kim
Journal: Blood (2007)
High Dose Therapy with Autologous Stem Cell Transplantation (HDT/ASCT) Support in Follicular Lymphoma (FL) a Very Long Follow-up Analysis of 640 Patients of Geltamo Spanish Group Suggests That FL Might be Cured, Even in High-Risk Patients
Authors: Ana Jiménez Ubieto, Carlos Grande García, Lucrecia Yáñez, Dolores Caballero, Silvana Novelli, María Jesús Rodriguez, María Manzanares, Reyes Arranz, Jose Javier Ferreiro, Sabella Bobillo, Santiago Mercadel, Andrea Galeo, Javier López, Carlos Vallejo, Carmen Albo, Elena Perez, Carmen Marrero, Laura Magnano, Luis Palomera, Isidro Jarque, Erika Coria, Teresa Palomo, Juan José Lahuerta, Armando Lopez-Guillermo, Antonio Salar
Journal: Blood (2014)
Optimization of Fludarabine + Melphalan Conditioning for Marrow Transplantation From Unrelated Donors for Patients with Hematopoietic Malignancies: A Prospective Dose-Finding Trial Using Modified Continual Reassessment Method.
Authors: Seitaro Terakura, Masashi Sawa, Haruhiko Ohashi, Tomonori Kato, Satoshi Nishiwaki, Nobuhiko Imahashi, Makoto Murata, Koichi Miyamura, Yoshiko Atsuta, Ritsuro Suzuki, Tomoki Naoe, Tatsuya Ito, Yoshihisa Morishita
Journal: Blood (2009)
Myeloproliferative Neoplasm Quality Of Life (MPN-QOL) Study Group: Observational Study Of Quality Of Life and Symptomatic Response In Myelofibrosis Patients Receiving Undergoing Treatment With Conventional Therapy, The Measures Trial and Allogeneic Stem Cell Transplant, The Symptoms Trial
Authors: Veena Fauble, Robyn M. Emanuel, Holly Lynn Geyer, Amylou Constance Dueck, Nicolaus Kroeger, Bart L Scott, Aaron T Gerds, Uday R Popat, Sergio A Giralt, Vikas Gupta, David Ross, Emily Knight, Ana Kerguelen Fuentes, Christen Lykkegaard Andersen, Elisabeth Ejerblad, Gunnar Birgegard, Peter Johansson, Bjorn Andreasson, Federico Sackmann, Jean-Loup Demory, Constantine S Tam, Jan J. Michiels, Deepti H Radia, Michael Boxer, Ruben A. Mesa
Journal: Blood (2013)
Old DAT / New Data : Positive Direct Antiglobulin Test Identifies a Specific Subgroup Of CLL Patients
Authors: Anne Quinquenel, Chadi Al Nawakil, Fanny Baran-Marszak, Virginie Eclache, Remi Letestu, Christine Le Roy, Nadine Varin-Blank, Alain Delmer, Vincent Levy, Florence Cymbalista
Journal: Blood (2013)
A Phase 1 Trial of Oral Ponatinib (AP24534) In Patients with Refractory Chronic Myelogenous Leukemia (CML) and Other Hematologic Malignancies: Emerging Safety and Clinical Response Findings
Authors: Jorge Cortes, Moshe Talpaz, Dale Bixby, Michael Deininger, Neil Shah, Ian W. Flinn, Michael Mauro, Thomas O'Hare, Simin Hu, Rebecca Kan, Victor M. Rivera, Tim Clackson, Frank Haluska, Hagop Kantarjian
Journal: Blood (2010)
Detection of Nucleophosmin Gene Mutations in Plasma from Patients with Acute Myeloid Leukemia: Clinical Significance and Implications.
Authors: Wanlong Ma, Xi Zhang, Iman Jilani, Farhad Ravandi, Elihu Estey, Hagop Kantarjian, Francis Giles, Mohammad Sheikholeslami, Michael Keating, Maher Albitar
Journal: Blood (2007)
Sequential High-Dose Dexamethasone and Response Adapted PAD (Bortezomib, Adriamycin, Dexamethasone) or VAD (Vincristine, Adriamycin, Dexamethasone) Induction Chemotherapy Followed by High-Dose Chemotherapy with Autologous Stem Cell Transplantation for Newly Diagnosed Multiple Myeloma; Open-Labelled, Multicenter Phase 2 Study (KMM-94 Study)-Interim Analysis
Authors: Jin Seok Kim, Cheolwon Suh, June-Won Cheong, Kihyun Kim, Yang Soo Kim, Se-Ryeon Lee, Sung Hwa Bae, Young-Don Joo, Sang Min Lee, Hyeon Seok Eom, Eunkyung Park, Sung-Soo Yoon, Inho Kim, Jae-Yong Kwak, Chang-Ki Min, Jeong-A Kim, Moo-Rim Park, Sung Hyun Kim, Hye Jin Kang, Min Kyoung Kim, Hawk Kim, Yeung-Chul Mun, Hoon-GU KIM, Moon Hee Lee, Jae Hoon Lee
Journal: Blood (2011)
Higher Expressions of PTH Receptor Type 1 and/or 2 in Bone Marrow Is Associated to Longer Survival in Newly Diagnosed Myeloma Patients Enrolled in Total Therapy 3
Authors: Maurizio Zangari, Caleb K Stein, Shmuel Yaccoby, Donghoon Yoon, Christoph Heuck, Yogesh Jethava, Donald Johann, Rashid Z Khan, Xenofon Papanikolaou, Frits van Rhee, Faith E Davies, Gareth J Morgan, Bart Barlogie
Journal: Blood (2014)
Feasibility Trial of Individualized Therapy for Relapsed or Refractory Acute Myeloid Leukemia Based on a High Throughput in Vitro Drug Sensitivity Assay
Authors: Pamela S. Becker, Vivian Oehler, Elihu H. Estey, Timothy Martins, Andrea Perdue, Jodie David, Sylvia Chien, Paul C. Hendrie, Fabiana Ostronoff, C. Anthony Blau
Journal: Blood (2014)
Cytogenetic Risk Stratification in Primary Versus Post-Essential Thrombocythemia / Post-Polycythemia Vera Myelofibrosis
Authors: Lucia Masarova, Prithviraj Bose, Naval G. Daver, Naveen Pemmaraju, Kate J Newberry, Jorge E. Cortes, Hagop M. Kantarjian, Srdan Verstovsek
Journal: Blood (2016)
Epigallocatechin-3-Gallate (EGCG), a Polyphenol Extracted from Green Tea, Has Significant In Vitro Activity Against Myeloma Cells.
Authors: Shaji Kumar, Michael M. Timm, Jessica L. Haug, Teresa K. Kimlinger, Linda Wellik, Michael P. Kline, S. Vincent Rajkumar
Journal: Blood (2006)
Oprozomib, Pomalidomide, and Dexamethasone (OPomd) in Patients (Pts) with Relapsed and/or Refractory Multiple Myeloma (RRMM): Initial Results of a Phase 1b Study (NCT01999335)
Authors: Jatin Shah, Ruben Niesvizky, Edward Stadtmauer, Robert M. Rifkin, James Berenson, Jesus G. Berdeja, Jeff P. Sharman, Roger Lyons, Zandra Klippel, Hansen Wong, Yu-Lin Chang, Saad Usmani
Journal: Blood (2015)
Treatment and outcome of IG-MYC+ neoplasms with precursor B-cell phenotype in childhood and adolescence
Authors: Heidi Herbrueggen, Stephanie Mueller, Jonas Rohde, Laura Arias Padilla, Anja Moericke, Andishe Attarbaschi, Martin Zimmermann, Richard Ratei, Monika Brueggemann, Reiner Siebert, Gudrun Goehring, Brigitte Schlegelberger, Jutta Bradtke, Wolfram Klapper, Willi Woessmann, Birgit Burkhardt
Journal: Leukemia (2019)
Plasma FGF23 Is a Biomarker for Left Ventricular Hypertrophy and Mortality in Adults with Sickle Cell Anemia Chronic Kidney Disease
Authors: Chia-Hao Liu, Olusola Laja, Laurel Mendelsohn, Kathleen Vaughan, Lena Diaw, Jefferey Kopp, James G. Taylor
Journal: Blood (2015)
The Inhibitory Receptor FcgRIIB Is Overexpressed, and Its Ligation by Anti- FcgRIIB Antibodies Suppresses IgM Production and Induces Apoptosis in Waldenstrom's Macroglobulinemia.
Authors: Guang Yang, Ping Gong, Lian Xu, Zachary Hunter, Jenny Sun, Bryan Ciccarelli, Yangsheng Zhou, Xia Liu, Hsiuyi Tseng, Yang Cao, Robert Manning, Megan Lewicki, Christina Hanzis, Thea Ioakimidis, Patricia Sheehy, Christopher J Patterson, Steven Treon
Journal: Blood (2009)
Functional Genomics and Computational Approaches Identify Novel Small Molecules Targeting Quiescent Leukemia Stem Cells
Authors: Costakis Frangou, Jason Den Haese, Jordan Warunek, Scott Portwood, Norma J Nowak, Andrei V Gudkov, Katerina Gurova, Meir Wetzler, Eunice S. Wang
Journal: Blood (2015)
EZH2 Mutations Can Be Detected in 23% of t(10;11)(p13;q14)/PICALM-MLLT10 Positive Acute Leukemias,
Authors: Vera Grossmann, Ulrike Bacher, Valentina Artusi, Hans-Ulrich Klein, Wolfgang Kern, Susanne Schnittger, Torsten Haferlach, Alexander Kohlmann, Claudia Haferlach
Journal: Blood (2011)
Proteomic/Transcriptomic Signatures of Infant MLL-r Rearranged B-ALL at Diagnosis and Relapse Reveal Lineage Plasticity and Diagnostic Heterogeneity
Authors: Jevon Cutler, Raiha Tahir, Rumen Kostadinov, Raja Sekhar, Tai-Chung Huang, Akhilesh Pandey, Patrick Brown, Mohammad Heydarian, Karen Reddy
Journal: Blood (2016)
Ketogenic diet and metabolic regulation of brain microglia
Authors: Adrian Benito, Nabil Hajji, Kevin O’Neill, Hector C Keun, Nelofer Syed
Journal: Neuro-Oncology (2019)

Abstract Ketogenic diet (KD) has been proposed as a coadjuvant therapy in the treatment of brain tumours. Reduction of blood glucose and increase in ketone bodies concentration are amongst the most important changes induced by KD in patients. Preliminary data collected in our lab indicates that KD induces substantial changes in the immune system in mice bearing brain tumours. Microglia are brain-resident immune cells that account for around 30% of the tumour mass and play a major role in controlling tumour progression by adopting a protumour (M2 polarisation) or antitumour (M1 polarisation) phenotype. We are interested in understating the molecular and metabolic determinants of microglia polarisation and how these can be modulated by the metabolic microenvironment and KD. We report some initial findings that indicate microglia adapt to changes in the metabolic microenvironment and that nutrient availability can modulate microglia activation and polarisation. We believe that the study of microglia metabolism and nutritional interventions like KD can provide new knowledge about the regulation of the brain immune system and unveil novel routes for brain cancer treatment.
PET Evaluation Before Autografting Has a Strong Prognostic Impact in High-Risk, Relapsed Follicular Lymphoma Patients
Authors: Loic Ysebaert, Jehan Dupuis, Michel Meignan, Anne Julian, Christian Recher, Murielle Roussel, Lucie Oberic, Karim Belhadj, Francoise Rigal-Huguet, Anne Huynh, Camille Laurent, Philippe Gaulard, Michel Attal, Corinne Haioun, Guy Laurent
Journal: Blood (2011)
Whole-Exome Sequencing Revealed No Recurrent Mutations within the PI3K Pathway in Relapsed Chronic Lymphocytic Leukemia Patients Progressing Under Idelalisib Treatment
Authors: Paolo Ghia, Viktor Ljungström, Eugen Tausch, Andreas Agathangelidis, Annika Scheffold, Lydia Scarfo, Billy Michael Chelliah Jebaraj, Carolyn J. Owen, Jacqueline C. Barrientos, Marc Zapatka, Veerendra Munugalavadla, Jeremiah D. Degenhardt, Yeonhee Kim, Ronald L. Dubowy, Lyndah K. Dreiling, Richard Rosenquist, Stephan Stilgenbauer
Journal: Blood (2016)
AG-221, a Small Molecule Mutant IDH2 Inhibitor, Remodels the Epigenetic State of IDH2-Mutant Cells and Induces Alterations in Self-Renewal/Differentiation in IDH2-Mutant AML Model in Vivo
Authors: Alan H. Shih, Kaitlyn R Shank, Cem Meydan, Andrew M. Intlekofer, Patrick Ward, Craig B. Thompson, Ari M Melnick, Jeremy Travins, Kim Straley, Camelia Gliser, Katherine Yen, Ross L Levine
Journal: Blood (2014)
A Potential New Application of Mobilization/Leukapheresis for Enrichment of Peripheral Blood in Circulating Non-Hematopoietic CXCR4+CD45− Tissue-Committed Stem Cells (TCSC) for Organ/Tissue Regeneration.
Authors: Magda Kucia, Ryan Reca, Marcin Wysoczynski, Jolanta Gozdzik, Janina Ratajczak, Anna Janowska-Wieczorek, Mariusz Z. Ratajczak
Journal: Blood (2004)
Normal B-Cell Gene Expression Signatures Classifies Chronic Lymphocytic Leukemia into Distinct Subtypes - Indication of Plasticity
Authors: Caroline Holm Nørgaard, Lasse Hjort Jakobsen, Andrew J. Gentles, Karen Dybkaer, Julie Støve Bødker, Alexander Schmitz, Preben Johansen, Karsten Spiekermann, Tobias Herold, Tarec Christoffer El-Galaly, Hans Erik Johnsen, Martin Bøgsted
Journal: Blood (2016)
Pediatric-Inspired Chemotherapy Incorporating Pegaspargase Is Safe and Results in High Rates of MRD Negativity in Adults Ages 18-60 with Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma
Authors: Mark Blaine Geyer, Ellen K. Ritchie, Arati V. Rao, M. Isabella Cazacu, Shreya Vemuri, Martin S. Tallman, Dan Douer, Jae H. Park
Journal: Blood (2018)
Biallelic Mutations in Tetratricopeptide Repeat Domain 26 (Intraflagellar Transport 56) Cause Severe Biliary Ciliopathy in Humans
Authors: Ranad Shaheen, Saud Alsahli, Nour Ewida, Fatema Alzahrani, Hanan E. Shamseldin, Nisha Patel, Awad Al Qahtani, Homoud Alhebbi, Amal Alhashem, Tarfa Al‐Sheddi, Rana Alomar, Eman Alobeid, Mohamed Abouelhoda, Dorota Monies, Abdulrahman Al‐Hussaini, Muneerah A. Alzouman, Mohammad Shagrani, Eissa Faqeih, Fowzan S. Alkuraya
Journal: Hepatology (2019)

Background and Aims The clinical consequences of defective primary cilium (ciliopathies) are characterized by marked phenotypic and genetic heterogeneity. Although fibrocystic liver disease is an established ciliopathy phenotype, severe neonatal cholestasis is rarely recognized as such. Approach and Results We describe seven individuals from seven families with syndromic ciliopathy clinical features, including severe neonatal cholestasis (lethal in one and necessitating liver transplant in two). Positional mapping revealed a single critical locus on chromosome 7. Whole‐exome sequencing revealed three different homozygous variants in Tetratricopeptide Repeat Domain 26 ( TTC26 ) that fully segregated with the phenotype. TTC26 (intraflagellar transport [IFT] 56/DYF13) is an atypical component of IFT‐B complex, and deficiency of its highly conserved orthologs has been consistently shown to cause defective ciliary function in several model organisms. We show that cilia in TTC26 ‐mutated patient cells display variable length and impaired function, as indicated by dysregulated sonic hedgehog signaling, abnormal staining for IFT‐B components, and transcriptomic clustering with cells derived from individuals with closely related ciliopathies. We also demonstrate a strong expression of Ttc26 in the embryonic mouse liver in a pattern consistent with its proposed role in the normal development of the intrahepatic biliary system. Conclusions In addition to establishing a TTC26 ‐related ciliopathy phenotype in humans, our results highlight the importance of considering ciliopathies in the differential diagnosis of severe neonatal cholestasis even in the absence of more typical features.
Clinical response to subsequent chemotherapy after nivolumab in patients with advanced gastric cancer
Authors: Kai Tsugaru, Yasutaka Sukawa, Keitaro Shimozaki, Kazuhiro Togasaki, Kenta Kawasaki, Kenro Hirata, Hideyuki Hayashi, Yasuo Hamamoto, Takanori Kanai, Hiromasa Takaishi
Journal: Annals of Oncology (2019)
Downing St adviser had links to Babylon Health, investigation finds
Authors: Abi Rimmer
Journal: BMJ (2019)

The prime minister’s senior adviser worked for the company that operates the controversial GP at Hand app, an investigation by the Guardian and the Bureau of Investigative Journalism has found.

Dominic Cummings, the investigation said, advised Babylon Health on its communications strategy and senior recruitment in July last year.1 Although his role at the company ended that month, he continued to advise the company until September 2018, it said.

Also in September last year the …
Clinical Phase II Study of WT1 Peptide Vaccination in Pediatric Leukemia Patients after Stem Cell Transplantation and Analysis of Immunological Monitoring
Authors: Yoshiko Hashii, Yoshihiro Oka, Takako Miyamura, Yusuke Oji, Naoki Hosen, Akihiro Tsuboi, Haruo Sugiyama, Keiichi Ozono
Journal: Blood (2014)