tbuckley/cabot-search huggingface dataset:
Abstract 127: Usefulness Of Kawasaki Disease Risk-scoring Systems For Initial Intravenous Immunoglobulin Resistance In Korean Patients with Kawasaki Disease
Authors: Mi Young Han, Jae Hoe Koo, Jung Yoon Cho, Kyung Lim Yoon, Sung Ho Cha
Journal: Circulation (2015)

Intravenous immunoglobulin (IVIG) infusion in the acute stage is the standard therapy in patients with Kawasaki disease (KD). Although some risk-scoring system made in Japan are widely used, there are few reports that describe the usefulness of risk-scoring systems to predict initial IVIG resistance. This study aimed to investigate which risk-scoring system of KD is the most useful. And this study evaluated the usefulness of N-terminal pro-brain natriuretic peptide (NT-proBNP) as an additional criteria of risk-scoring system. In this study, 228 patients with a diagnosis of KD who received IVIG treatment were viewed retrospectively. Of these 228 patients, 27 were nonresponders who received additional rescue therapy. The Kobayashi score (responders n=201, non-responders n=27) showed statistically significant difference between IVIG-sensitive and IVIG-resistant patients, yielding a sensitivity of 83 % and specificity of 67 %. The Egami score (responders n=201, non-responders n=27) also showed statistically significant difference between IVIG-sensitive and IVIG-resistant patients, yielding a sensitivity of 38 % and specificity of 92 %. The Sano score (responders n=108, non-responders n=15) also showed statistically significant difference between IVIG-sensitive and IVIG-resistant patients, yielding a sensitivity of 52 % and specificity of 90 %. The new risk-scoring system ( Kobayashi risk-scoring + NT-proBNP &gt; 1093 pg/mL, responders n=201, non-responders n=27, high risk ≥ 5 points ) also showed statistically significant difference between IVIG-sensitive and IVIG-resistant patients, yielding a sensitivity of 83 % and specificity of 71 %. This findings show the new risk-scoring system is helpful in determining patients at risk for non-responders to initial IVIG treatment. This study suggest that in patients with high risk defined as ≥ 5 points, risk calculation by new scoring system are likely to fail to the initial IVIG therapy and may require further rescue therapy in Korean Kawasaki disease patients .
Pediatricians Awakened: Addressing Family Immigration Status as a Critical and Intersectional Social Determinant of Health
Authors: Julie M. Linton, Nusheen Ameenuddin, Olanrewaju Falusi
Journal: The American Journal of Bioethics (2019)

This article refers to:Clinical Ethicists Awakened: Addressing Two Generations of Clinical Ethics Issues Involving Undocumented Patients
Complex Simplicity and Hirschsprung’s Disease
Authors: Allan M. Goldstein, Nancy J. Cox
Journal: New England Journal of Medicine (2019)

Science envy comes in many flavors, and it is particularly easy to envy those who are privileged to discover simple stories. A study by Tilghman et al. on the genetic risk of Hirschsprung's disease, published in this issue of the Journal,1 is a reminder of the critical lessons learned and insights gained through discovering the complexity behind what once appeared to be simple. Hirschsprung's disease is highly heritable, and yet it is not obviously mendelian in its transmission through families. It was, nevertheless, one of the first complex diseases in which genetic risk factors were discovered, and the relatively large . . .
Abstract P347: The Relationship Between Renal Artery Calcium and Kidney Function: the Multi-Ethnic Study of Atherosclerosis
Authors: Devesh Vashishtha, Robyn McClelland, Joachim Ix, Dena Rifkin, Nancy Jenny, Matthew Allison
Journal: Circulation (2017)

Background: Renal Artery Calcium (RAC) has been shown to be associated with a higher odds of hypertension (HTN). The purpose of this study was to determine if the presence and extent of RAC is associated with significant differences in several measures of kidney function. Methods: We analyzed cross-sectional data from the Multi-Ethnic Study of Atherosclerosis (MESA). During MESA follow-up visits 2 and 3, a random subsample of 1226 participants underwent computed tomography (CT) of the abdomen and also had venous blood samples assayed for kidney function. RAC was the primary predictor variable and the following measures of kidney function were the outcome variables: eGFR, cystatin-C, micro and macroalbuminuria and CKD stage. CKD stage was divided into the following groups: stage 1 GFR &lt; 90mL/min, stage 2 GFR 60-89 mL/min, stage 3A GFR 45-59 mL/min, and stage 3B GFR 30-44 mL/min. There were no study participants in the stage 4 category of GFR &lt; 30mL/min. The analyses were adjusted for age, gender, race, height, visceral fat, dyslipidemia, diabetes, cigarette smoking, hypertension, interleukin-6 (IL-6), coronary artery calcium (CAC), abdominal aortic calcium (AAC), renin and aldosterone. Findings: The average age of this cohort was 66.1 years (SD 9.7) and 44.8% (549 of 1226) were male, 36.3% (445 of 1226) Caucasian, 14.1% (173 of 1226) Chinese-American, 21.6% (265 of 1226) African-American and 28.0% (343 of 1226) Hispanic-American. Compared with those with no RAC, those with RAC &gt; 0 were significantly older but not different by gender or race. After adjustment for age, sex and race, those with RAC &gt; 0 had significantly higher visceral fat, were more likely to have dyslipidemia, diabetes and hypertension, had a higher IL6, and a higher prevalence of CAC and AAC &gt; 0. In fully adjusted multivariable linear regression models, the presence of RAC was associated with higher creatinine (β = 0.052, p = 0.01) and Cystatin-C (β = 0.052, p &lt; 0.01), as well as a lower eGFR (β = -2.209, p = 0.06). In logistic regression, the presence of RAC was also associated with albuminuria but after adjustment for cardiovascular risk factors including dyslipidemia, diabetes, smoking and hypertension, this association was no longer significant. In fully adjusted ordinal logistic regression, RAC as a continuous variable was associated with increased odds of being in a higher CKD category (β = 1.14, p = 0.05). Discussion: Our results suggest a modest relationship between RAC and kidney function, when measured by creatinine, Cystatin-C, eGFR and CKD stage. As such, the identification of RAC on abdominal CT scans obtained as part of clinical practice may be considered in the prevention of chronic kidney disease.
Impact of Multiple Myocardial Scars Detected by CMR in Patients Following STEMI
Authors: Kathrine Ekström, Lars Nepper-Christensen, Kiril A. Ahtarovski, Kasper Kyhl, Christoffer Göransson, Litten Bertelsen, Adam A. Ghotbi, Henning Kelbæk, Steffen Helqvist, Dan E. Høfsten, Lars Køber, Mikkel M. Schoos, Niels Vejlstrup, Jacob Lønborg, Thomas Engstrøm
Journal: JACC. Cardiovascular imaging (2019)
Inhaled corticosteroids and the risk of lung cancer in COPD: a population-based cohort study
Authors: Adam J.N. Raymakers, Mohsen Sadatsafavi, Don D. Sin, J. Mark FitzGerald, Carlo A. Marra, Larry D. Lynd
Journal: European Respiratory Journal (2019)

Inhaled corticosteroids (ICSs) are often prescribed in patients with chronic obstructive pulmonary disease (COPD). Their impact on the risk of lung cancer, a leading cause of mortality in COPD patients, remains uncertain. Population-based linked administrative data between the years 1997 and 2007 from the province of British Columbia, Canada, were used to evaluate the association between lung cancer risk and ICS use in COPD patients. COPD was defined on the basis of receipt of three COPD-related prescriptions in subjects ≥50 years of age. Exposure to ICS was incorporated into multivariable Cox regression models using several time-dependent methods (“ever” exposure, cumulative duration of use, cumulative dose, weighted cumulative duration of use and weighted cumulative dose). There were 39 676 patients who met the inclusion criteria. The mean± sd age of the cohort was 70.7±11.1 years and 53% were female. There were 994 (2.5%) cases of lung cancer during follow-up. In the reference case analysis (time-dependent “ever” exposure), ICS exposure was associated with a 30% reduced risk of lung cancer (HR 0.70 (95% CI 0.61–0.80)). ICS exposure was associated with a decrease in the risk of lung cancer diagnosis over all five methods of quantifying exposure. This population-based study suggests that ICS use reduces the risk of lung cancer in COPD patients.
CT-guided cutting needle lung biopsy using “Liquid Withdraw” technique: Incidence of pneumothorax when combined with co-axial technique.
Authors: Rutian Li, Baorui Liu, Hang Zhang, Wei Ren, Xiaoping Qian, Lifeng Wang
Journal: Journal of Clinical Oncology (2015)

e22225 Background: CT-guided cutting needle lung biopsy is important for the diagnosis of lung cancer. The co-axial method is now widely used. However, the co-axial method failed to decrease the incidence of pneumothorax. This study investigates whether our new-developed “Liquid withdraw” technique (to inject small amount of lidocaine while withdrawing the needle) can reduce incidence of pneumothorax when combined with co-axial technique. Methods: From Jan 2013 to Dec 2014, we retrospectively studied 38 CT-guided percutaneous lung biopsies using co-axial and liquid withdraw techniques. The pathologies and complications secondary to biopsy procedure (pneumothorax, bleeding and hemoptysis) were noted. Pneumothorax was graded as mild, moderate, and severe. Results: 37 cases were diagnosed out of 38 biopsies, of which 23 cases were adenocarcinoma (21 patients consented to EGFR mutation test, and 15 cases had EGFR mutations), 2 squamous cell carcinoma, 1 non-small cell lung cancer (cannot be further classified after IHC), 1 small-cell lung cancer, 2 primary lung cancer of other types, 5 metastatic lung cancer and 3 benign diseases. Four cases (10.5%) experienced pneumothorax (all were mild pneumothorax), bleeding during biopsy happened in 1 (2.6%) case, 6 cases with a small amount of hemoptysis (15.8%). No infection, tumor implantation, or aeroembolism occurred. Conclusions: CT-guided percutaneous lung biopsy using co-axial and liquid withdraw is an accurate, safe, reliable technique. Compared to co-axial technique without liquid withdraw, the incidence of pneumothorax was reduced from approximately 35% to 10.5%. More studies according to liquid withdraw technique will be conducted in our future work.
FRI-276-Effect of korean red ginseng on non-alcohlic steatohepatitis: Randomized controlled trial
Authors: Sang Joon Yoon, Nayoung Lee, Dae Hee Han, Haripriya Gupta, Gi Soo Youn, Ki Tae Suk, Dong Joon Kim, Young Lim Ham
Journal: Journal of Hepatology (2019)
SAT-006-Efficacy of oral thrombopoietin receptor agonist lusutrombopag in chronic liver disease by underlying disease aetiology
Authors: Naim Alkhouri, Michio Imawari, Namiki Izumi, Yukio Osaki, Toshimitsu Ochiai, Roy Bentley, Takeshi Kano
Journal: Journal of Hepatology (2019)
Abstract 10938: Outcomes of Coronary Artery Bypass Grafting in 1.9 Million Medicare Patients From 1999-2010
Authors: Justin M Schaffer, Bharathi Lingala, James I Fann, Thomas A Burdon, W D Ogden, Y J Woo, Jack H Boyd
Journal: Circulation (2015)

Introduction: Coronary artery bypass grafting (CABG) remains a mainstay of treatment in patients with coronary artery disease. Outcomes of CABG from a large modern U.S. cohort (the Medicare database) were analyzed, with a focus on outcomes. Methods: Medicare patients undergoing CABG from 1999-2010 were assessed. ICD-9 and CPT codes were used to describe operative details. Survival distributions were estimated with the Kaplan-Meier method, and compared with an age-/sex-/race-matched general US population cohort. A Cox proportional hazards analysis determined variables associated with survival. Cubic-spline analyses were used to assess hospital and surgeon volume-outcome relationships. Results: Median survival following CABG for the entire cohort (n=1,902,315) was 9.43 years (95% confidence intervals [CI] 9.41-9.45) (Figure 1A), and was 10.02 years (95% CI: 10.00-10.04) in isolated CABG (n=1,523,529) recipients (Figure 1B). During the 12 year study period, Medicare patients underwent CABG at 1,391 U.S. hospitals and by 5,899 U.S. surgeons. Multivariable analysis identified multiple predictors of death including age, gender, race, patient comorbidities, prior cardiac surgery, year of operation, adjunct cardiac procedures (e.g. valve repair/replacement or aortic repair), the lack of internal mammary artery (IMA) use, the absence of billing for cardiopulmonary bypass, and both hospital and surgeon volume. A transition point was identified in the surgeon-volume and hospital-volume relationships suggesting a volume beyond which additional case numbers only improved outcomes minimally (Figures 1C/1D). Conclusions: Survival following CABG in Medicare patients is robust. Even in this elderly cohort, the use of a single IMA was associated with significantly improved outcomes, and bilateral IMA use was associated with an even lower hazard for death compared with single IMA. Both hospital and surgeon volume had strong associations with survival.
Ferroptosis, a new form of cell death: opportunities and challenges in cancer
Authors: Yanhua Mou, Jun Wang, Jinchun Wu, Dan He, Chunfang Zhang, Chaojun Duan, Bin Li
Journal: Journal of Hematology & Oncology (2019)

Ferroptosis is a novel type of cell death with distinct properties and recognizing functions involved in physical conditions or various diseases including cancers. The fast-growing studies of ferroptosis in cancer have boosted a perspective for its usage in cancer therapeutics. Here, we review the current findings of ferroptosis regulation and especially focus on the function of ncRNAs in mediating the process of cell ferroptotic death and on how ferroptosis was in relation to other regulated cell deaths. Aberrant ferroptosis in diverse cancer types and tissues were summarized, and we elaborated recent data about the novel actors of some "conventional" drugs or natural compounds as ferroptosis inducers in cancer. Finally, we deliberate future orientation for ferroptosis in cancer cells and current unsettled issues, which may forward the speed of clinical use of ferroptosis induction in cancer treatment.
PS-076-Antiviral activity of JNJ-4964 (AL-034/TQ-A3334), a selective toll-like receptor 7 agonist, in AAV/HBV mice after oral administration for 12 weeks
Authors: Florence Herschke, Chris Li, An De Creus, Ren Zhu, Qinglin Han, Qing Lu, Tse -I Lin
Journal: Journal of Hepatology (2019)
TCTAP C-208 Appearance of Peri-stent Contrast Staining in Everolimus Eluting Stent After Target Vessel Revascularization
Authors: Wataru Yamamoto, Satoru Otsuji, Katsuyuki Hasegawa, Kasumi Ishibuchi, Yorihiko Higashino
Journal: Journal of the American College of Cardiology (2019)
SAT-218-Impact of sofosbuvir-based therapy on renal functions indices in chronic hepatitis c patients who achieved sustained virological response
Authors: Rabab Omar, Reham Abdelmoniem, Mohammed El-Kassas, Mohammad El-Sayed, Aisha Elsharkawy, Zeinab Abdellatif, Shereen Abdel Alem, Gamal Esmat
Journal: Journal of Hepatology (2019)
Prevention of hand foot syndrome using an antioxidant containing ointment in patients treated with pegylated liposomal doxorubicin  a randomized placebo controlled double-blind study.
Authors: Sora Jung, Juergen Lademann, Alexa Patzelt, Franziska Kluschke, Radoslav Chekerov, Jalid Sehouli
Journal: Journal of Clinical Oncology (2015)

e20679 Background: Hand foot syndrome (HFS) or palmoplantar erythrodysesthesia (PPE) is a dose-limiting cutaneous side effect with an incidence of up to 78% in patients treated with pegylated liposomal doxorubicin (PLD), hence being one of its most frequent side effects. These skin lesions can cause a major impairment in the patients’ quality of life. Limited efficacy of symptomatic treatment often requires dose reduction or discontinuation of chemotherapy. Recently, PPE has been described as a local toxic effect resulting from radical formation after excretion of PLD with the sweat on the skin surface after systemic application. In the present study, the preventive effect of a radical scavenging ointment compared to a placebo ointment was investigated. Methods: The primary endpoint of this randomized placebo controlled double-blind study was to compare the occurrence rate of PPE grade 3 in the verum and placebo group. Patients treated with 40-50 mg/m2 PLD every 4 weeks were included. The ointment was applied at least 3 times daily on the hands and twice on the feet starting 3 days prior to the first cycle of PLD. The observation period ranged from the first to the fourth cycle of PLD with a follow-up period of 4 months. Patients were examined by an oncologist and a trained dermatologist at least every 4 weeks. Results: 27 patients were enrolled in this study, of which 13 (48.1%) patients were able to complete the study. 4 (30.8%) of these patients developed grade 3 PPE, all belonging to the placebo group. The application of the antioxidant containing ointment showed a significant effect in the prevention of PPE grade 3 (p = 0.021, Fisher’s exact test) as well as a reduction in maximal severity grade (2.6±0.89 to 1.6±0.55) and occurrence (83.3% to 71.4%) of PPE. All grade 3 PPE patients were unblinded and treated with the verum ointment. As a result, PPE was strongly reduced in these patients so that chemotherapy could be continued. Conclusions: The topical application of an antioxidant containing ointment with a high radical protection factor has to be considered as an effective prevention strategy for pegylated liposomal doxorubicin-induced PPE.
Agreement to Regulate Cell-Based Meat Products
Authors: Feyza Sancar
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Analysis of the role of tumor infiltrating lymphocytes in different malignancies.
Authors: Patricia Arboleda Ezcurra, Carlos Castaneda Altamirano, Miluska Castillo Garcia, Valeria Villegas, Sandro Casavilca Zambrano, Esperanza Milla, Ketty Dolores Cerna, Carolina Belmar Lopez, Henry Guerra, Henry Leonidas Gomez, Tatiana Vidaurre
Journal: Journal of Clinical Oncology (2015)

e22102 Background: Tumor Infiltrating Lymphocytes(TIL) are associated with better outcome in melanoma.Recent publications suggest that they also predict prognosis and response to anticancer agents in diverse neoplasms.However, used methodologies and description of TIL compartments differs among malignancies. We evaluated TIL distribution and its association with clinicopathological features in melanoma and in different epithelial malignancies. Methods: We evaluated TIL percentage through H&E in 28 samples of acral melanomas.We translated this methodology to evaluate intraepithelial(IE),stromal(S) and invasive border (IB) compartment of epithelial malignancies.We selected surgical samples of Gastric(21),Lung(51),Tongue(49) and Cervical(40)cancer. Results: Median age for Melanoma,Gastric,Lung,Tongue and Cervical Cancer was 66.5,61,62,57 and 48, respectively. Most clinical stage for Melanoma,Gastric,Lung,Tongue and Cervical Cancer was II(50%),III(47.62%),IV(45.1%),III(34.69%) and I(85%),respectively.Adenocarcinoma histology for Gastric,Lung,Tongue and Cervical Cancer was 100%,94.12%,2.04%, and 12.5%,respectively.Median IE TIL in Gastric,Lung,Tongue and Cervical Cancer was 1±0,1±2,5±4.5 and 5±4.5,respectively.Median S TIL in melanoma,Gastric,Lung,Tongue and Cervical Cancer was 40±31.25,10±7.5,20±15,30±25,60±20,respectively.Median IB TIL in Gastric,Lung,Tongue and Cervical Cancer was 20±15, 10±12.5, 40±20 and 40±20 respectively.Compartments were significantly correlated in Gastric(IE vs S r = 0.453,p = 0.0449),Lung (IE vs S r = 0.4392,p = 0.004/S vs IB r = 0.5102,p = 0.0002),Tongue(IE vs S r = 0.369,p = 0.0091/S vs IB r = 0.6362,p = 0.0001) and Cervical Cancer(S vs IB r = 0.6273,p = 0.0001).S TIL and IB TIL was associated to clinical stage (p = 0.0019 and p = 0.001 respectively). S TIL was associated to disease free survival(p = 0.023) Conclusions: TIL evaluation is a replicable methodology for different epithelial malignancies and could provide relevant prognostic information
THU-101-Artery density in human liver: A valuable measure for staging of chronic liver disease
Authors: Ian Wanless, Yameng Sun, Bingqiong Wang, Hong You, Ji-Dong Jia, Shuyan Chen, Xiaoning Wu, Jialing Zhou, Xiaojuan Ou, Priyanka Ravi, Ashley Stueck
Journal: Journal of Hepatology (2019)
EGFR testing by a new diagnostic method to detect point mutations, deletions and insertions associated to non small cell lung cancer: CLARTCMA EGFR.
Authors: Maria Jesus Sanz, Nuria Manjon, Ana Aragon, Juan Moscoso del Prado, Jose Luis Rodriguez-Peralto, Javier Hernandez-Losa, Julian Sanz, Javier Gomez-Roman, Michele Biscuola, Enrique Alava, Rosario Cospedal, Maria Luisa Villahermosa
Journal: Journal of Clinical Oncology (2015)

e19095 Background: The Epidermal Growth Factor Receptor (EGFR) mutation status is an important clinical variable for treatment indication in non-small-cell lung cancer (NSCLC). Around 30% NSCLC carry activating mutations in EGFR leading to a constitutive activation of the EGFR protein. The most prevalent EGFR mutations include deletions in exon 19, and mutation L858R in exon 21 (85% of EGFR mutations in NSCLC). CLART CMA EGFR kit is a novel diagnostic assay, based upon multiplex ARMS-PCR and microarray detection system (CLART technology) to detect a total of 40 high-prevalence mutations associated with a known sensitivity or resistance to tyrosine kinase inhibitor treatment. Methods: We designed specific ARMS-primers and hybridization probes for detecting point mutations G719A, G719C and G719S in exon 18, the 28 most prevalent deletions in exon 19, mutations S768I and T790M in exon 20, 5 insertions in exon 20, and mutations L858R and L861Q in exon 21 of EGFR. Clinical testing was performed using 406 samples which contained the targets of this assay and samples with wild type alleles. The results were cross checked by comparison to Sanger sequencing methodology. Results: Analytical sensitivity was assessed using recombinant plasmids, results ranged between 100-1000 copies/µl for all mutations and deletions, excepting low prevalence mutations L861Q, S768I, and insertions in exon 20, which were between 10e4-10e5copies/µl. Mutations L861Q, L858R and T790M were analyzed using specific cell lines, the sensitivity was between 0,1-1ng. Diagnostic sensitivity data was over 95% for all mutations except for S786I, and diagnostic specificity data was over 99% for all mutations. Concordance between present assay and Sanger sequencing was ≥ 95%. Conclusions: CLART CMA EGFR simultaneously detects the most prevalent point mutations, deletions and insertionsin EGFR with sensitivity ≥ 95% and reproducibility ≥ 91%, being capable of detecting mutations in samples with less than 5% mutated alleles. Our data support the use of this technology for clinical testing prior to selection of the appropriate treatment in NSCLC.