AB0446 CLINICAL AND IMMUNOLOGICAL CHARACTERISTICS OF 484 SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS IN XINJIANG OF CHINA: A COMPARATIVE ANALYSIS
Authors: Y. M. Shi, X. Wu, L. Wu, C. N. Luo
Journal: Annals of the Rheumatic Diseases (2020)

Background: Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease. Epidemiological studies in SLE have been reported in the literature in many countries and ethnic groups. Although SLE in China has been described in the past, there has not been a detailed evaluation of SLE patients in Xinjiang of China, a largely Uygur population. Objectives: To describe the clinical featuresand immunological features of 484 SLE subjects. Methods: 484 adult patients followed in the The People’s Hospital of the Xinjiang Uygur Autonomous Region, 211 patients with Uygur SLE as welI as 273patients with Han SLE. Results: Of the 211 Uygur SLE patients, 195 (92.4%) were female and 16 (7.6%) were male (female:male=12.2:1),the mean age at SLE onset was 34.67±11.57 years, mean disease duration was 20.77±35.16 months.Of the 273 Han SLE patients,247(90.5%)were female and 26(9.5%) were male,the mean age at SLE onset was 36.68±14.44 years,mean disease duration was 41.64±61.89 months.(2)between the Uygur and Han SLE patients,the Raynaud phenomenon(χ 2 =6.066 P=0.014), Chest pain(χ 2 =7.906 P=0.005), headache(χ 2 =4.572 P=0.029)has obvious differences(table 1).(3)The anti-nuclear (χ 2 =8.108 P=0.004), anti-AHA (χ 2 =4.952 P=0.026)were higer in Uygur SLE patients than those in Han SLE patients;the Uygur SLE patients has been anemia(χ 2 =6.904,P=0.009), high level of immunoglobulin (χ 2 =8.939,P=0.003),decrease of complement(χ 2 =6.330 P=0.012).(table 2) figure 1. Clinical manifestations Clinical manifestations Uygur SLE patients(n=211) Han SLE (n=273) χ 2 P rash 106(50.2%) 157(57.5%) 2.537 0.111 Photosensitivity 40(19%) 56(20.5%) 0.181 0.670 Alopecia 73(34.6%) 101(37.0%) 0.298 0.585 Oral ulcers 49(23.2%) 64(23.5%) 0.006 0.937 Raynaud phenomenon 28(13.3%) 60(22%) 6.066 0.014 livedo reticularis 5(2.4%) 7(2.6%) 0.020 0.866 arthralgia/arthritis 105(49.8%) 159(58.5%) 3.623 0.057 abnormal liver-function 8(3.8%) 7(2.6%) 0.597 0.440 Chest pain 28(13.3%) 16(5.9%) 7.906 0.005 Suffocation 49(23.2%) 52(19%) 1.256 0.262 palpitation 27(12.8%) 41(15%) 0.487 0.485 Shortness of breath 24(11.4%) 35(12.8%) 0.233 0.630 Ophthalmia 2(0.9%) 6(2.2%) 1.154 0.283 Visual impairment 1(0.5%) 3(1.1%) 0.567 0.457 hemiplegia 1(0.5%) 0(0.0%) 1.297 0.436 Mental disorder 4(1.9%) 11(4.0%) 1.804 0.179 headache 14(6.6%) 7(2.6%) 4.572 0.029 Lower Limb Edem 36(17.1%) 34(12.5%) 2.042 0.153 pleurisy 37(17.5%) 43(15.8%) 0.256 0.613 pericarditis 38(18%) 33(12.1%) 3.273 0.070 pulmonary fibrosis 7(3.3%) 9(3.3%) 0.000 0.982 figure 2. immunological manifestations manifestations Uygur SLE patients(n=211) Han SLE (n=273) χ 2 P antinuclear antibodies 185(87.7%) 212(77.7%) 8.108 0.004 anti-dsDNA 115(54.5%) 144(52.7%) 0.147 0.701 anti-SSA 101(47.9%) 149(54.6%) 2.147 0.143 anti-SSB 45(21.3%) 63(23.1%) 0.210 0.647 anti-Sm 44(21%) 68(25%) 1.088 0.297 ACL 29(13.8%) 26(9.5%) 2.161 0.142 antiU1-RNP 74(35.1%) 100(36.6%) 0.126 0.723 anti-AHA 60(28.4%) 54(19.8%) 4.952 0.026 Low white blood cell 46(22.1%) 79(29%) 2.938 0.087 anemia 90(42.9%) 85(36.3%) 6.904 0.009 Thrombocytopenia 36(17.1%) 51(18.7%) 0.212 0.645 Urine protein positive 84(39.8%) 114(41.9%) 0.217 0.641 Rise of urine RBC 29(13.7%) 35(12.8%) 0.088 0.766 Increased immunoglobulin 82(38.9%) 71(26.1%) 8.939 0.003 Complement decline 120(57.1%) 124(45.6%) 6.330 0.012 Conclusion: The Uygur SLE patients have their own clinical and immunological characteristics, which has guiding significance in the diagnosis, treatment and prognosis of SLE. References: [1]Martyna TS,Hanna SS, Marek F. Clinical and immunological characteristics of Polish patients with systemic lupus erythematosus. Adv Clin Exp Med. 2018;27(1):57–61 [2]Maloney K C, Ferguson T S, Stewart H D, et al. Clinical and immunological characteristics of 150 systemic lupus erythematosus patients in Jamaica: A comparative analysis[J]. Lupus, 2017, 26(13):961203317707828. [3]Ching K H, Burbelo P D, Christopher T, et al. Two Major Autoantibody Clusters in Systemic Lupus Erythematosus[J]. PLoS ONE, 2012, 7(2):e32001. Disclosure of Interests: None declared