Fanconi Syndrome and Tenofovir Alafenamide: A Case Report
Authors: Nathan C. Bahr, Sri G. Yarlagadda
Journal: Annals of Internal Medicine (2019)

Letters4 June 2019Fanconi Syndrome and Tenofovir Alafenamide: A Case ReportNathan C. Bahr, MD and Sri G. Yarlagadda, MDNathan C. Bahr, MDUniversity of Kansas, Kansas City, Kansas (N.C.B., S.G.Y.) and Sri G. Yarlagadda, MDUniversity of Kansas, Kansas City, Kansas (N.C.B., S.G.Y.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L18-0592 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: In the United States, tenofovir disoproxil fumarate (TDF) has been almost completely replaced by tenofovir alafenamide (TAF) for treatment of HIV infection and chronic hepatitis B virus infection. This change occurred in part because TAF causes less injury to the kidney than TDF (1).Objective: To alert clinicians to the possibility that TAF can cause Fanconi syndrome.Case Report: A 54-year-old man with HIV infection came to our institution to establish an ongoing source of care. In 1994, he had been diagnosed elsewhere with HIV. His HIV had been well controlled with antiretroviral regimens containing TDF for the 10 ...References1. Sax PE, Wohl D, Yin MT, Post F, DeJesus E, Saag M, et al; GS-US-292-0104/0111 Study Team. Tenofovir alafenamide versus tenofovir disoproxil fumarate, coformulated with elvitegravir, cobicistat, and emtricitabine, for initial treatment of HIV-1 infection: two randomised, double-blind, phase 3, non-inferiority trials. Lancet. 2015;385:2606-15. [PMID: 25890673] doi:10.1016/S0140-6736(15)60616-X CrossrefMedlineGoogle Scholar2. Álvarez H, Mariño A, Valcarce N, García-González J, Díaz-Cambre H, Llibre JM. Overdose of elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide in an HIV-1-infected subject with attempted suicide. Infection. 2018. [PMID: 30145772] doi:10.1007/s15010-018-1201-x CrossrefMedlineGoogle Scholar3. Novick TK, Choi MJ, Rosenberg AZ, McMahon BA, Fine D, Atta MG. Tenofovir alafenamide nephrotoxicity in an HIV-positive patient: a case report. Medicine (Baltimore). 2017;96:e8046. [PMID: 28885375] doi:10.1097/MD.0000000000008046 CrossrefMedlineGoogle Scholar4. Serota DP, Franch HA, Cartwright EJ. Acute kidney injury in a patient on tenofovir alafenamide fumarate after initiation of treatment for hepatitis C virus infection. Open Forum Infect Dis. 2018;5:ofy189. [PMID: 30151414] doi:10.1093/ofid/ofy189 CrossrefMedlineGoogle Scholar5. Edwards IR, Aronson JK. Adverse drug reactions: definitions, diagnosis, and management. Lancet. 2000;356:1255-9. [PMID: 11072960] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Kansas, Kansas City, Kansas (N.C.B., S.G.Y.)Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L18-0592.This article was published at Annals.org on 29 January 2019. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoFanconi Syndrome and Tenofovir Alafenamide Nathan C. Bahr and Sri G. Yarlagadda Fanconi Syndrome and Tenofovir Alafenamide Hortensia Álvarez and Josep M. Llibre Metrics Cited byTenofovir alafenamide nephrotoxicity: a case report and literature reviewSafety of Tenofovir Alafenamide in People With HIV Who Experienced Proximal Renal Tubulopathy on Tenofovir Disoproxil FumarateManagement of Patients With Chronic Hepatitis B (Hepadnaviridae) and Chronic Hepatitis D Infection (Deltavirus)Renal proximal tubulopathy in an HIV-infected patient treated with tenofovir alafenamide and gentamicin: a case reportContemporary issues and new challenges in chronic kidney disease amongst people living with HIVTherapeutic management of HIV-infected patients with chronic kidney diseaseCoronavirus disease 2019: acute Fanconi syndrome precedes acute kidney injuryEarly safety of tenofovir alafenamide in patients with a history of tubulopathy on tenofovir disoproxil fumarate: a randomized controlled clinical trialFanconi Syndrome and Tenofovir AlafenamideHortensia Álvarez, MD and Josep M. Llibre, MD, PhDProximal renal tubular acidosis with and without Fanconi syndromeKidney Disease in HIV InfectionTenofovir alafenamide 4 June 2019Volume 170, Issue 11Page: 814-815KeywordsAcute renal failureAntiretroviralsCreatinineDrugsHIVHIV infectionsRenal failureThyroxineToxicityUltrasound imaging ePublished: 29 January 2019 Issue Published: 4 June 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...