tbuckley/cabot-search huggingface dataset:
ATIM-37. PHASE II, OPEN-LABEL, SINGLE ARM, MULTICENTER STUDY OF AVELUMAB WITH HYPOFRACTIONATED RADIATION (HFRT) FOR ADULT PATIENTS WITH SECONDARILY TRANSFORMED IDH-MUTANT GLIOBLASTOMA (GBM)
Authors: Sylvia Kurz, Joshua S Silverman, Tsivia Hochman, Lakshmi Nayak, Isabel Arrillaga-Romany, Eudocia Lee, Amie Patel, Malcolm Delara, Fraustina Hsu, Tooba Imtiaz, Lori Magnelli, Jennie Taylor, Timothy Cloughesy, Erik Sulman, John Golfinos, David Zagzag, Matija Snuderl, Judith D Goldberg, Andrew S Chi
Journal: Neuro-Oncology (2019)

Abstract BACKGROUND There is no effective therapy for patients (pts) with IDH-mutant gliomas that progress after RT and chemotherapy. At time of progression, these tumors have often transformed to glioblastoma (GBM) and have increased numbers of somatic mutations, i.e. have a “hypermutator phenotype”. We hypothesized that there is synergistic efficacy of Avelumab (anti-PD-L1) combined with HFRT in pts with secondarily transformed IDH-mutant GBMs. Safety-lead-in results will be presented. METHODS This is a phase II, open-label, single-arm, multicenter study of Avelumab with HFRT in adults with transformed IDH-mutant GBM who previously received RT and TMZ and/or PCV. All pts received Avelumab 10 mg/kg IV followed at Day 8 by HFRT (25 Gy in 5 daily 5-Gy fractions) and then Avelumab 10 mg/kg IV every 2 weeks. A 3 + 3 design was used for a 6-patient safety-lead-in cohort. Adverse events were recorded according to CTCAE. RESULTS Six pts (F=4, M=2) with a median age= 45.5 yrs (range 31.5–54.4 yrs) were enrolled in the safety-lead-in cohort. No DLT was observed. Grade ≥ 3 AEs included increased cerebral edema (3 pts), hyponatremia (1 pt) and worsening hemiparesis (3 pts). Grade ≤ 2 AEs included nausea, hypothyroidism, lymphopenia, thrombocytopenia, transaminase elevation, and fever/chills. Median follow-up time was 8.9 mo. Best treatment response was SD in 1 patient. At time of last follow-up all pts have discontinued treatment for PD. Median PFS was 4.2 mo (range 1.4–5.7). Median OS was 10.1 (range 6.8–21+) mo. 4 pts (67%) died, 2 pts remain alive in follow-up at 6.9 and 21.6 months after treatment initiation. The study was closed after the safety lead-in completed enrollment due to slow accrual. CONCLUSIONS Avelumab combined with HFRT was tolerable without dose-limiting toxicity in this safety-lead-in cohort of adult patients with transformed IDH-mutant GBM. Further studies are necessary to determine efficacy of this treatment regimen.
The Burden of Relapsed/Refractory Multiple Myeloma: An Indirect Comparison of Health-Related Quality of Life Burden across Different Types of Advanced Cancers at Baseline and after Treatment Based on HORIZON (OP-106) Study of Melflufen Plus Dexamethasone
Authors: Paul G. Richardson, Alessandra Larocca, Xavier Leleu, Albert Oriol, Agne Paner, Paula Rodriguez Otero, Cyrille Touzeau, Adrián Alegre Amor, Christopher Maisel, María-Victoria Mateos, Amitabha Mazumder, Peter Strang, Oskar Öhman, Johan Harmenberg, Stojan Zavisic, Joan Bladé
Journal: Blood (2019)
Prevalence of homologous recombination deficiency (HRD)-related signatures indicates that a wider range of prostate cancer patients may benefit from PARP-inhibitor therapy
Authors: Z. Sztupinszki, M. Diossy, M. Krzystanek, J. Borcsok, M. Pomerantz, V. Tisza, S. Spisak, O. Rusz, I. Csabai, M. Freedman, Z. Szallasi
Journal: Annals of Oncology (2019)
Implementing a Structured Health Care Transition (HCT) Process for Sickle Cell Disease (SCD) Using Quality Improvement (QI): Early Results of a SCD HCT Learning Collaorative
Authors: Ifeyinwa (IFY) Osunkwo, Courtlandt Cheryl, Charity Patterson, Noonan Laura, Jennifer Cornette, Peggy McManus, White Patience, Raymona Holloway Lawrence
Journal: Blood (2019)
The Addition of Ibritumomab Tiuxetan (IT) to the ATG/TLI Preparative Regimen Is Safe and May Enhance Post-Transplant Response and Outcomes for Patients with Relapsed or Refractory B Cell Non-Hodgkin Lymphomas
Authors: Michael Low Cardenas, Mehrdad Abedi, Christina Romo, Carol M. Richman, Megan Daly, Joseph Tuscano
Journal: Blood (2019)
Targeting the p62-ZZ/N-End Rule Pathway in Multiple Myeloma Overcomes Proteasome Inhibitor-Resistance Via Induction of Necroptosis and Enhances the Bone Anabolic Effects of Proteasome Inhibitors
Authors: Silvia Marino, Daniela Nicoleta Petrusca, Edward Simpson, Judith L Anderson, Xiang-Qun Xie, Yunlong Liu, John Chirgwin, G. David Roodman
Journal: Blood (2019)
CMET-05. EVALUATING RADIATION NECROSIS IN PATIENTS WITH INTRACRANIAL METASTASES FROM MELANOMA
Authors: Victoria Edmonds, Holly Thomson, Akanksha Sharma, Richard Butterfield, Nan Zhang, Terence Sio, Sujay Vora, Thomas Daniels, Steven Schild, Jonathan Ashman, Naresh Patel, Richard Zimmerman, Maciej Mrugala, Thomas DeLeon, Alan Bryce, Alyx Porter
Journal: Neuro-Oncology (2019)

Abstract BACKGROUND Radiation is an integral component of the multidisciplinary treatment of patients with intracranial metastasis (ICM) from melanoma. The risk of radiation necrosis (RN) post-treatment can range from 5–25%. We retrospectively evaluated pre- and post-radiation clinical and radiographical characteristics in patients with ICM from melanoma to identify potential risk factors for RN. METHODS After IRB approval, patients with ICM from melanoma who received radiation at our institution between 2013 and 2018 were retrospectively reviewed. We recorded demographics, intracranial metastasis (burden and location), systemic therapy, resection, stereotactic radiosurgery versus whole brain radiation, and outcomes. Brain MRI was evaluated using the Response Assessment in Neuro-Oncology criteria (RANO). RESULTS A total of 27 patients were included in the study. RN was diagnosed in 14 patients (52%) at one month to three years following radiation. Cerebellar location (n=7) was significantly associated with RN (p=0.0058). Metastasis-associated hemorrhage was present in 7 patients, 6 of which developed RN (43% vs 8%, p=0.08). Surgical resection prior to radiation was performed in 9 patients, 7 of which developed RN (50% vs 15%, p=0.1). RN appeared to be less often diagnosed when ICM were treated with higher doses of radiation (24 Gy vs 20 Gy, p=0.07). Systemic treatment was administered prior to radiation in 25 patients and we found no relationship with systemic therapy type and RN. Presumed RN was treated in 12 of 14 patients (86%). Steroids or surgical resection were the primary treatment modalities, with laser ablation used in 1 case. Following treatment, improvement was noted in 3 patients radiographically and in 1 of these clinically. CONCLUSIONS This series of patients with radiotherapy-treated brain metastases from melanoma reveals cerebellar involvement, hemorrhage, and prior surgical resection as potential risk factors for radiation necrosis. Neoadjuvant systemic treatment did not appear to be a risk factor in our review.
A Clinical Prediction Score for Course of Disease in Newly Diagnosed Childhood Immune Thrombocytopenia
Authors: David Schmidt, Katja M.J. Heitink-Pollé, C. Ellen van der Schoot, Leendert Porcelijn, Gestur Vidarsson, Marrie Bruin, Johanna G. van der Bom, Masja De Haas
Journal: Blood (2019)
Zika virus seroprevalence in blood donors from the Northeastern region of São Paulo State, Brazil, between 2015 and 2017
Authors: Svetoslav Nanev Slavov, Rafael Rahal Guaragna Machado, Alexander Rodrigo Ferreira, Camila Pereira Soares, Danielle Bastos Araujo, Danielle Bruna Leal Oliveira, Dimas Tadeu Covas, Edison Luiz Durigon, Simone Kashima
Journal: Journal of Infection (2019)
SF3B1 Mutations Induce Oncogenic IRAK4 Isoforms and Activate Targetable Innate Immune Pathways in MDS and AML
Authors: Gaurav S Choudhary, Molly A Smith, Andrea Pellagatti, Tushar D Bhagat, Shanisha Gordon, Sanjay Pandey, Nishi Shah, Srinivas Aluri, Robert N Booher, Murali Ramachandra, Maria Elena Samson, Kith Pradhan, Teresa V. Bowman, Manoj M Pillai, Chandan Guha, Amittha Wickrema, Britta Will, Aditi Shastri, Ulrich G. Steidl, Jacqueline Boultwood, Daniel T. Starczynowski, Amit Verma
Journal: Blood (2019)
Foetal Death after Pethidine and Promazine
Authors: J. MacVicar
Journal: BMJ (1963)

with the tissue-buffering mechanism for storage of catechol amines.Under these circumstances it is also likely that the tissue monoamine system is more sensi- tive to the action of ephedrine and amphetamine.It is clear that tranylcypromine should never be given either in the form of " parstelin " (tranylcypromine and trifluo- perazine) or of " parnate " (tranylcypromine) within one to two weeks of giving ephedrine or amphetamine as well.In view of the pharmacological action of the drug on so many systems it should probably not be given with anything else at all, at any rate in the present state of our knowledge.The side-effects of tranylcypromine are due to amine-oxidase inhibition, but there is comparatively little to suggest that this is true of its antidepressant action.One hopes that it will be possible to separate these effects.since the practical difficulty of ensuring that a patient will not con- sume other tablets as well as tranylcypromine makes the drug a liability in prac- tice.Although all these effects have been known since 1960 they are often still unrecognized.-Iam, etc.,
Serum Neutrophil Gelatinase-Associated Lipocalin Independently Predicts for Renal Response in Myeloma Patients with Severe Renal Impairment
Authors: Meletios A. Dimopoulos, Maria Roussou, Eftathios Kastritis, Alexandra Margeli, Evangelos Eleutherakis-Papaiakovou, Ioannis Ntanasis-Stathopoulos, Nikolaos Kanellias, Gerasimos-Petros Papassotiriou, Despina Fotiou, Magdalini Migkou, Maria Gavriatopoulou, Erasmia Psimenou, Ioannis Papassotiriou, Evangelos Terpos
Journal: Blood (2019)
Specific targeting cancer cells with nanoparticles and drug delivery in cancer therapy
Authors: Sibi Raj, Sartaj Khurana, Ramesh Choudhari, Kavindra Kumar Kesari, Mohammad Amjad Kamal, Neha Garg, Janne Ruokolainen, Bhudev C. Das, Dhruv Kumar
Journal: Seminars in Cancer Biology (2019)
Bone Conduction in Otosclerosis
Authors: H. Macnaughton-Jones
Journal: BMJ (1948)

less severely.Clearly muscular tenseness from anxiety or any other cause will augment pain."From the foregoing it is contended that pain felt in labour is a physiological response to uterine ischaemia, cervical dilata- tion, and stretching of the passages.As in pain from other sources, percention may be modified by the emotional state, which is doubly important in that it may influence actual uterine functioning.While therefore certain obstetricians are able to conduct relatively painless childbirth without anaesthe- sia, this is a tribute to their enthusiasm, personality, skill, and zeal rather than a proof that childbirth is " normally" free from pain.The great majority of parturient women will con- tinue to require some form of analgesia, local or general, and no vague philosophical concepts should be allowed to interfere with progress in this direction.-Iam, etc., London.W.2.
S100A9 Contributes to T Cell Dysfunction through Its Interaction with RAGE in MDS
Authors: Wendy Kandell, Thu Le Trinh, Xianghong Chen, Pingyan Cheng, Danielle Gilvary, Yin-Kai Chen, Alexandra Calescibetta, Erika Adriana Eksioglu, Alan F. List, Sheng Wei
Journal: Blood (2019)
Circulating Tumor Cells (CTCs) for Comprehensive and Multiregional Non-Invasive Genetic Characterization of Multiple Myeloma (MM)
Authors: Juan José Garcés, Gabriel Bretones, Leire Burgos, Rafael Valdes-Mas, Diego Alignani, Diana Álvarez Puente, Ibai Goicoechea, Miguel García Álvarez, Sonia Garate, Idoia Rodriguez, Maria Jose Calasanz, Paula Rodriguez, Rafael Rios, Joaquin Martinez-Lopez, Pamela Millacoy, Luis Palomera, Rafael Del Orbe, Albert Pérez, Xabier Agirre, Juan Flores-Montero, Luzalba Sanoja-Flores, Alberto Orfao, Halima El Omri, Felipe Prosper, Carlos Lopez-Otin, Jesús San-Miguel, Bruno Paiva
Journal: Blood (2019)
Dose-Dependent Iron Chelating Effects of Eltrombopag on in Vitro Human Megakaryopoiesis
Authors: Zhi-Jian Liu, Emoke Deschmann, Haley E. Ramsey, Henry Feldman, Bethan Psaila, Nichola Cooper, Evangelia Vlachodimtropoulou Koumoutsea, John B. Porter, James B. Bussel, Michael Georgieff, Martha Sola-Visner
Journal: Blood (2019)
A Phase II, Prospective, Randomized, Multicenter, Open-Label Study of GX-188E, an HPV DNA Vaccine, in Patients with Cervical Intraepithelial Neoplasia 3
Authors: Youn Jin Choi, Soo Young Hur, Tae-Jin Kim, Sung Ran Hong, Jae Kwan Lee, Chi-Heum Cho, Ki Seok Park, Jung Won Woo, Young Chul Sung, You Suk Suh, Jong Sup Park
Journal: Clinical Cancer Research (2019)

Abstract Purpose: To determine the efficacy of the therapeutic DNA vaccine GX-188E for inducing regression of cervical intraepithelial neoplasia (CIN) 3. Patients and Methods: We conducted a prospective, randomized, multicenter, open-label, phase II clinical trial of GX-188E in CIN3 patients positive for human papillomavirus (HPV) type 16/18. The primary endpoint was to determine the histopathologic regression to ≤CIN1 at visit seven (V7; 20 weeks after the first GX-188E injection), and an extension study was pursued until visit 8 (V8; 36 weeks after the first GX-188E injection). HPV-sequencing analysis and an ex vivo IFNγ ELISpot assay were performed using the collected cervical biopsy and blood samples from patients. Results: In total, 72 patients were enrolled and underwent randomization. Of them, 64 patients were included in per-protocol analysis (V7) and 52 in extension analysis (V8). Our data showed 52% (33/64) of patients at V7 and 67% (35/52) of patients at V8 presented histopathologic regression after receiving the GX-188E injection. We found that 73% (V7) and 77% (V8) of the patients with histologic regression showed HPV clearance. HPV clearance and histopathologic regression were significantly associated at V7 and at V8. Compared with the measurements at V1 (baseline), the patients at V8 with HPV clearance showed significantly higher fold changes in their IFNγ ELISpot responses compared with those without HPV clearance. The HPV sequence analysis revealed that the HPV type 16 E6/E7 variants D25E, V83L, and N29S were inversely associated with histopathologic regression at V8. Conclusions: GX-188E is an effective therapeutic vaccine against a cohort containing only CIN3 patients.
Abstract 14816: Electronic Cigarette Use is Associated With Altered Lipid Profiles in the CITU Study
Authors: Sana Majid, Kathleen L McGlasson, Jessica L Fetterman, Rachel J Keith, Robert M Weisbrod, Joseph N Palmisano, Rosa Breton-Romero, Bihua Feng, Comreen Vargees, Aruni Bhatnagar, Rose M Robertson, Naomi M Hamburg
Journal: Circulation (2019)

Electronic cigarettes (e-cigarettes) are increasingly used by current and former smokers. Whether e-cigarette use lowers cardiovascular (CV) risk is poorly defined. Traditional cigarettes (t-cigare...
Progressive Down Regulation of JAK-STAT, Cell Cycle, and ABC Transporter Genes in CD34+/Lin- Cells of Chronic-Phase Chronic Myeloid Leukemia (CP-CML) Patients at Diagnosis Vs. 12 Months of Nilotinib Treatment Vs. Healthy Subjects
Authors: Alessandra Trojani, Ester Pungolino, Giuseppe Rossi, Mariella D'adda, Luca Emanuele Bossi, Giacomo Baruzzo, Barbara Di Camillo, Alessandra Perego, Mauro Turrini, Chiara Elena, Lorenza Maria Borin, Alessandra Iurlo, Simona Malato, Francesco Spina, Maria Luisa Latargia, Pierangelo Spedini, Salvatore Artale, Michela Anghilieri, Maria Cristina Carraro, Cristina Bucelli, Gabriella De Canal, Enrica Morra, Roberto Cairoli
Journal: Blood (2019)
Resetting Policies to End Family Homelessness
Authors: Ellen L. Bassuk, Jacqueline A. Hart, Effy Donovan
Journal: Annual Review of Public Health (2019)

Homelessness is a devastating experience for children and their families. Families, the majority of whose members are children, now comprise more than one-third of the overall US homeless population. Most of these children are less than six years old. Various assumptions have driven policy and the allocation of resources to programs serving these families. Although decades of research and field experience suggest strategies for preventing and reducing this problem, perspectives differ, hindering the development of effective solutions. In this article, we explore some of these assumptions, including ( a) definitions of homelessness used to count the numbers of families and determine resource allocation, ( b) the needs of children and responses to the impact of adverse childhood experiences, and ( c) whether services matter and should be integrated with affordable housing. We conclude by suggesting various directions to ensure that these children are protected and have the opportunity to grow and thrive.
Medical Education in the United States
Authors: M R ZAVON
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myeloid Leukemia Stem Cells Depend on Phospholipase C Gamma 1 (Plcg1) Signaling
Authors: Tina M. Schnoeder, Patricia Arreba-Tutusaus, Juliane Mohr, Soenke Weinert, Stephanie Frey, Anja Sammt, Lars Bullinger, Florian H. Heidel
Journal: Blood (2016)
Plant-Based Dietary Patterns and Incidence of Type 2 Diabetes—Reply
Authors: Frank Qian, Qi Sun
Journal: JAMA Internal Medicine (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Trends in Self-perceived Weight Status, Weight Loss Attempts, and Weight Loss Strategies Among Adults in the United States, 1999-2016
Authors: Liyuan Han, Dingyun You, Fangfang Zeng, Xiaoqi Feng, Thomas Astell-Burt, Shiwei Duan, Lu Qi
Journal: JAMA Network Open (2019)

The self-perception of weight and weight loss attempts might promote weight loss and maintenance.To examine trends in current measured body mass index (BMI) and weight, self-reported weight, self-perceived weight status, weight loss attempts, and weight loss strategies among adults in the United States.This national cross-sectional study used data from continuous National Health and Nutrition Examination Survey (NHANES) data sets (1999-2000 to 2015-2016). Participants were US residents older than 20 years. Data were analyzed from January 2018 to December 2018.Current measured BMI and weight, self-reported weight, self-perceived weight status, weight loss attempts, and applied weight loss strategies. Adjusted, self-reported, prior-year weight was calculated using correction equations that considered age, sex, race/ethnicity, and quartile of self-reported prior-year weight.Data were collected from 48 026 participants (19 792 [41.2%] aged 40-64 years; 24 255 [50.5%] women; 21 725 [45.2%] white) through 9 surveys from 1999-2000 to 2015-2016. Increasing trends were observed in current measured BMI (difference, 1.20; 95% CI, 0.92-1.47; P for trend < .001), current measured weight (difference 2.77 kg; 95% CI, 1.92-3.61 kg; P for trend < .001), adjusted, self-reported, prior-year weight (difference, 2.36 kg; 95% CI, 1.52-3.21 kg; P for trend < .001), and the difference between measured and adjusted self-reported weight (difference 0.70 kg; 95% CI, 0.34-1.07 kg; P for trend < .001). During this period, the proportion of overall participants who had attempted to lose weight increased from 34.3% to 42.2% (difference, 8.0%; 95% CI, 4.1%-10.5%; P for trend < .001). The most commonly reported weight loss strategies with the most rapidly increasing prevalence during the study period were reduced food consumption (21.2%-31.9%; difference, 11.1%; 95% CI, 8.2%-13.3%; P for trend < .001), exercise (18.2%-31.5%; difference, 14.4%; 95% CI, 11.3%-16.9%; P for trend < .001), and frequent water intake (0.2%-26.3%; difference, 26.2%; 95% CI, 24.1%-29.0%; P for trend < .001). Between 2005-2006 and 2015-2016, increases were also observed for the reported consumption of more fruits, vegetables, and salads (0.1%-29.4%; difference, 30.3%; 95% CI, 28.1%-31.2%; P for trend < .001), changing eating habits (0.3%-20.5%; difference, 20.2%; 95% CI, 19.1%-22.3%; P for trend < .001), and the consumption of less sugar, candy, and sweets (0.2%-20.9%; difference, 21.7%; 95% CI, 19.3%-22.6%; P for trend < .001).In this cross-sectional study, our data indicated an increasing trend in the proportion of participants who attempted to lose weight and a parallel increasing trend in current measured BMI and weight among adults in the United States.
FDA Analysis of Survival Outcomes in Older Adults with Relapsed-Refractory Multiple Myeloma (RRMM) Treated with Novel Drug Regimens
Authors: Bindu Kanapuru, Susan Jin, Kunthel By, Theresa Carioti, Yuan-Li Shen, Rajeshwari Sridhara, Nicole J Gormley, Ann T. Farrell, Richard Pazdur
Journal: Blood (2019)
Decreased GABA-A Receptor Binding in Association With β-Lactam Antibiotic Use
Authors: Anthime Flaus, Daniela Alexandra Riaño Barros, Rainer Hinz, James F. Myers, Anne Lingford-Hughes, Matthias J. Koepp, Alexander Hammers, Colm Joseph McGinnity
Journal: Clinical Nuclear Medicine (2019)

β-Lactam antibiotics are proconvulsive. In laboratory animals, this effect seems to be predominantly mediated through inhibition of GABA-A receptors, but it has not been demonstrated in humans in vivo. We report images of a [C]Ro15-4513 PET from a 40-year-old man who had completed a 1-week course of flucloxacillin before it. Relative to healthy controls, the participant had significantly lower mean gray matter binding. These novel data suggest that, in humans, the proconvulsive effect of β-lactam antibiotics is mediated via either competition for the same benzodiazepine-binding site as [C]Ro15-4513 or downregulation of GABA-A receptor expression.
Prognostic Implications of Metabolic Total Volume and Total Lesion Glycolysis Assessed By PET/CT Combined with High Levels of Bone Marrow Plasma Cells Percentages As a Potential Risk Model in Patients with Newly Diagnosed Multiple Myeloma
Authors: Toshiki Terao, Yoichi Machida, Takafumi Tsushima, Akihiro Kitadate, Daisuke Miura, Kentaro Narita, Masami Takeuchi, Kosei Matsue
Journal: Blood (2019)