Abstract P2-12-13: Patient reported outcome measures in breast cancer patients in a Brazilian private hospital
Authors: Maira Caleffi, Renata M. Adamy, Maiara A. Floriani, Rosane M.L. Teixeira, Carla F. Gomes, Renata F. dos Santos, Fernanda V.D. Masseroni, Gisele A. Nader, Luiz A. Nasi, Mohamed P. Mutlaq, Daniela Dornelles Rosa
Journal: Cancer Research (2020)

Abstract Introduction: Breast cancer is the leading cause of death from cancer among women with a high incidence in Southern Brazil (crude rate estimated at 114.25/100,000 for 2018). Since survival of patients with breast cancer is improving all over the world, patient reported outcomes (PROs) are of great importance for evaluating treatment decisions and outcomes. The International Consortium for Health Outcomes Measurement (ICHOM) developed standard sets of health outcome measures for specific medical conditions and breast cancer was among the first conditions covered. We recently adopted ICHOM in our institution as a standard set of health outcome measures for several medical conditions, including breast cancer. This study aimed to add knowledge on PROMs within a Brazilian breast cancer population sample from a private hospital. Material and methods: All participants were recruited prospectively and asked to complete the PROMs as proposed in the international ICHOM breast cancer outcome set after diagnosis and before treatment of breast cancer. The generic PROM EORTC-QLQ-C30 and the disease specific-PROM EORTC-QLQ-BR23 modules were applied. Scores range from 0 to 100; higher scores represent a higher quality of life, except for ‘Breast symptoms’/‘Arm symptoms’, ‘Pain’ and ‘Fatigue’.Normative scores of the EORTC-QLQ-C30 and references scores for the EORTC-QLQ-BR23 were used. Results: We obtained data from the first 164 patients who entered the ICHOM. Median age was 55.8 years; 94% were Caucasian, 66% married, 17% premonopausal and 16% had in situ ductal carcinoma and 84% had invasive carcinoma. Depression was present at baseline in 17% of patients. The worst scores in QLQ-BR23 were related to sexual function and to the perspectives patients had related to their future (Table 1). Emotional function was the lowest in QLQ-C30 (Table 1). Discussion and conclusion: Breast cancer diagnosis is associated with emotional, physical and social distress. ICHOM is a tool to guide treatment and discuss quality and functioning throughout care by the multidisciplinary health team. We found a low score for sexual function among our patients after the diagnosis of breast cancer (before the initiation of oncologic treatment). This drives our attention to establish medical and psychological interventions before starting treatment, since surgery, chemotherapy and hormonal therapy may worsen all aspects of sexuality. It is important to note that these results are initial and after future prospective analyzes we may determine the influence of treatment on quality of life scores. Table 1. PROMs score [mean (IQR)] for all participantsAll (n=164)EORTC-QLQ-C30Global Health Status75.0 (66.67.34 -87.50)Physical Functioning93.34 (80.00 - 100)Role Functioning100 (100 - 100)Emotional Functioning66.67 (41.67 - 83.34)Cognitive Functioning83.34 (66.67 - 100)Social Functioning100 (83.34 - 100)Pain10 (0 - 16.67)Fatigue111.12 (0 - 22.23)EORTC-QLQ-BR23Body Image100 (83.34 - 100)Sexual Functioning33.34 (0 - 66.67)Sexual Enjoyment66.67 (66.67 - 100)Future Perspective33.34 (0 - 66.67)Breast Symptoms18.34 (0 - 25.0)Arm Symptoms10 (0 - 11.12)1Higher scores represent lower quality of life, IQR = interquartile range Citation Format: Maira Caleffi, Renata M. Adamy, Maiara A. Floriani, Rosane M.L. Teixeira, Carla F. Gomes, Renata F. dos Santos, Fernanda V.D. Masseroni, Gisele A. Nader, Luiz A. Nasi, Mohamed P. Mutlaq, Daniela Dornelles Rosa. Patient reported outcome measures in breast cancer patients in a Brazilian private hospital [abstract]. In: Proceedings of the 2019 San Antonio Breast Cancer Symposium; 2019 Dec 10-14; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(4 Suppl):Abstract nr P2-12-13.