THU0686 Changes in health-related quality of life over 5 to 8 years in 1347 patients with early arthritis or early inflammatory back pain
Authors: D. Puyraimond-Zemmour, B. Granger, A. Molto, C. Gaujoux-Viala, F. Guillemin, A. Ruyssen-Witrand, M. Dougados, B. Fautrel, L. Gossec
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Health-related quality of life (HRQoL) is a priority for patients. <h3>Objectives</h3> The objectives were to describe the changes in HRQoL over 5–8 years in patients with early arthritis (EA) or early inflammatory back pain (IBP), and to explore factors associated with HRQoL. <h3>Methods</h3> In 2 prospective observational French cohorts (ESPOIR for EA patients and DESIR for early IBP patients), HRQoL was assessed every 6 months during the first 24 months and then every year over 5–8 years, using the SF36 physical composite score (PCS) and mental composite score (MCS) (range 0–100, US population norm: 50). Disease activity was assessed by DAS28-ESR and ASDAS-CRP. Univariate and multivariate linear mixed-effect models, and trajectory-based mapping (k-means) were applied. <b>Figure 1</b> Evolution of SF36-MCS and PCS over follow-up in EA and early IBP <h3>Results</h3> In all, 1 347 patients (701 EA and 646 early IBP) were analysed: mean age 48.4±12.2 and 33.9±8.7 years respectively; mean disease duration 3.4±1.7 and 18.2±10.8 months, 76.3% and 55.0% females. At baseline, in EA, mean PCS and MCS were respectively 40.2±9.1 and 40.4±11.2, and in early IBP respectively 38.5±8.5 and 39.8±10.9. Over follow-up, HRQoL mean levels and trajectories improved mostly over the first 6 months (p&lt;0.001). Overall, 54%–61% of patients reached levels of HRQoL close to population norms. DAS28-ESR and ASDAS-CRP over time were related to PCS (range of explained variance: 9%&gt;43%, p&lt;0.001 in the mixed models) but not to MCS. Lines represent changes of mean SF36-MCS and mean SF36-PCS for EA and IBP; 95% confidence intervals were not represented because they were very small; The number of available data is between 696 and 508 according to the timepoint for SF-36 in EA and 646 to 422 according to the timepoint for SF-36 in IBP. <h3>Conclusions</h3> HRQoL was altered similarly for both physical and mental aspects in EA and early IBP. More than half the patients reached levels of HRQoL close to the general population. Disease activity only partly explained HRQoL: the drivers of HRQoL should be further explored. <h3>References</h3> [1] Dougados M, et al. Clinical presentation of patients suffering from recent onset chronic inflammatory back pain suggestive of spondyloarthritis: The DESIR cohort.Joint Bone Spine2015. [2] Combe B, et al. The ESPOIR cohort: a ten-year follow-up of early arthritis in France: methodology and baseline characteristics of the 813 included patients. Joint Bone Spine2007. <h3>Acknowledgements</h3> DESIR was financially supported by unrestricted grants from both the French Society of Rheumatology (FSR) and Pfizer-Wyeth Ltd France. ESPOIR was financially supported by an unrestricted grant from Merck Sharp and Dohme for the first 5 years. Part of the biological database was supported by two additional grants from Institut National de la Santé et de la Recherche Médicale (INSERM). The ESPOIR cohort study was supported by the FSR, AbbVie, Pfizer and Roche Chugai. <h3>Disclosure of Interest</h3> None declared