tbuckley/cabot-search huggingface dataset:
Prospective Implementation of a Risk Prediction Model for Bloodstream Infection Safely Reduces Antibiotic Usage in Febrile Pediatric Cancer Patients Without Severe Neutropenia
Authors: Adam J. Esbenshade, Zhiguo Zhao, Alaina Baird, Emily A. Holmes, Daniel E. Dulek, Ritu Banerjee, Debra L. Friedman
Journal: Journal of Clinical Oncology (2020)

Management of febrile pediatric patients with cancer with an absolute neutrophil count of 500/µL or greater is unclear. The Esbenshade Vanderbilt (EsVan) risk prediction models have been shown to predict bloodstream infection (BSI) likelihood in this population, and this study sought to prospectively validate and implement these models in clinical practice.Data were prospectively collected on febrile pediatric patients with cancer with a central venous catheter from April 2015 to August 2019 at a single site, at which the models (EsVan: 2015 to 2017; EsVan2: October 2017 to 2019) were initially developed and subsequently implemented for clinical management in well-appearing nonseverely neutropenic individuals. It was recommended that patients with low BSI risk (< 10%) be discharged home without antibiotics, those with intermediate BSI risk (10%-39.9%) be administered an antibiotic before discharge, and those with high BSI risk (> 40%) be admitted on broad-spectrum antibiotics. Seven-day outcomes were then collected and EsVan models were prospectively validated and C-statistics estimated.In 937 febrile, nonsevere neutropenia episodes, frequencies of low-, intermediate-, and high-risk episodes were 88.9%, 8.6%, and 2.3% respectively. BSI incidence was 4.2% (39 of 937). Within risk groups, low-risk BSI incidence was 1.9% (16 of 834) with BSI incidence of 13.6% and 54.5% for intermediate- and high-risk episodes, respectively. Empirical intravenous antibiotics were administered in 21.1% of low-risk episodes at presentation and at 7 days postpresentation, 72.3% of episodes never required intravenous antibiotics. There were no deaths or clinical decompensations attributable to antibiotic delay. For BSI detection, EsVan and EsVan2 models applied to the new cohort achieved C-statistics of 0.802 and 0.824, respectively.Prospective, real-time clinical utilization of the EsVan models accurately predicts BSI risk and safely reduces unnecessary antibiotic use in febrile, nonseverely neutropenic pediatric patients with cancer.
A Fully Human Monoclonal IgG Phosphorylcholine Antibody Prevents Accelerated Atherosclerosis in Mice
Authors: K. Pettersson, M.M. Ewing, M.R. de Vries, R. Atout, M. Nordzell, D.J. Sexton, F. Charlotte, W. Jukema, E. Ninio, S. Karabina, P. Quax
Journal: Circulation (2011)
FRI0078 Long term results of yttrium-90 radiosynoviorthesis in chronic knee synovitis of different origin
Authors: M Szentesi, S Takács
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> <h3>Objectives</h3> Authors report on the results of Yttrium-90 radiosynoviorthesis in chronic synovitis of the knee joint. Out of these 213 patients 122 suffered from rheumatoid arthritis, 17 ankylosing spondylitis,13 other seronegative spondylarthritis, 48 suffered from inflamed osteoarthritis, 1 hydrops articulorum intermitterns, l synovitis villonodularis, 11 from chronic traumatic synovitis. <h3>Methods</h3> Evaulation was based on the criteria as described by Müller, Rau and Scütte the score system was developed by the authors. <h3>Results</h3> In the first seven years excellent and good results were recorded in 71%. They achieved excellent as well as good results at 83% of patients with rheumatoid arthritis, at 50% of patients with ankylosing spondylitis and at 55% of patients with osteoarthritis. Seven years after radiosynoviorthesis 65% of patients did not need another punction. <h3>Conclusion</h3> Radiosynoviorthesis is as effective method of treating chronic synovitis as surgical synovectomy. The treatment must be done in rheumatoid arthritis Steinbrocker stadium I-II, local stadium I-II.
Time to Rethink Surveillance Testing Prior to Kidney Transplant
Authors: Mohammed Ruzieh, Andrew J. Foy
Journal: JAMA Internal Medicine (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Astrocytic STAT3 activation and chronic itch require IP3R1/TRPC-dependent Ca2+ signals in mice
Authors: Miho Shiratori-Hayashi, Chiharu Yamaguchi, Kazushi Eguchi, Yuto Shiraishi, Keita Kohno, Katsuhiko Mikoshiba, Kazuhide Inoue, Motohiro Nishida, Makoto Tsuda
Journal: Journal of Allergy and Clinical Immunology (2020)
The role of exome sequencing in newborn screening for inborn errors of metabolism
Authors: Aashish N. Adhikari, Renata C. Gallagher, Yaqiong Wang, Robert J. Currier, George Amatuni, Laia Bassaganyas, Flavia Chen, Kunal Kundu, Mark Kvale, Sean D. Mooney, Robert L. Nussbaum, Savanna S. Randi, Jeremy Sanford, Joseph T. Shieh, Rajgopal Srinivasan, Uma Sunderam, Hao Tang, Dedeepya Vaka, Yangyun Zou, Barbara A. Koenig, Pui-Yan Kwok, Neil Risch, Jennifer M. Puck, Steven E. Brenner
Journal: Nature Medicine (2020)
Bone Mass and Density in Youth With Type 2 Diabetes, Obesity, and Healthy Weight
Authors: Joseph M. Kindler, Andrea Kelly, Philip R. Khoury, Lorraine E. Levitt Katz, Elaine M. Urbina, Babette S. Zemel
Journal: Diabetes Care (2020)

OBJECTIVE Youth-onset type 2 diabetes is an aggressive condition with increasing incidence. Adults with type 2 diabetes have increased fracture risk despite normal areal bone mineral density (aBMD), but the influence of diabetes on the growing skeleton is unknown. We compared bone health in youth with type 2 diabetes to control patients with obesity or healthy weight. RESEARCH DESIGN AND METHODS Cross-sectional study of youth (56% African American, 67% female) ages 10–23 years with type 2 diabetes (n = 180), obesity (BMI &amp;gt;95th; n = 226), or healthy weight (BMI &amp;lt;85th; n = 238). Whole-body (less head) aBMD and lean mass as well as abdominal visceral fat were assessed via DXA. Lean BMI (LBMI) and aBMD SD scores (z scores) were computed using published reference data. RESULTS We observed age-dependent differences in aBMD and LBMI z scores between the healthy weight, obese, and type 2 diabetes groups. In children, aBMD and LBMI z scores were greater in the type 2 diabetes group versus the obese group, but in adolescents and young adults, aBMD and LBMI z scores were lower in the type 2 diabetes group versus the obese group (age interactions P &amp;lt; 0.05). In the type 2 diabetes group and the obese group, aBMD was about 0.5 SDs lower for a given LBMI z score compared with healthy weight control patients (P &amp;lt; 0.05). Further, aBMD was lower in those with greater visceral fat (β = −0.121, P = 0.047). CONCLUSIONS These results suggest that type 2 diabetes may be detrimental to bone density around the age of peak bone mass. Given the increased fracture risk in adults with type 2 diabetes, there is a pressing need for longitudinal studies aimed at understanding the influence of diabetes on the growing skeleton.
Development of Promitil®, a lipidic prodrug of mitomycin c in PEGylated liposomes: From bench to bedside
Authors: Alberto Gabizon, Hilary Shmeeda, Esther Tahover, Gleb Kornev, Yogita Patil, Yasmine Amitay, Patricia Ohana, Eli Sapir, Samuel Zalipsky
Journal: Advanced Drug Delivery Reviews (2020)
Medicaid Expansion and Rates of Opioid-Related Hospital Use
Authors: Arshjot Khokhar, Anuj V. Mehta, Kenneth John
Journal: JAMA Internal Medicine (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Commentaire du travail de Sato H et al., pp. 122
Journal: Endoscopy (2015)

See also: Utility of intrapapillary capillary loops seen on magnifying narrow-band imaging in estimating invasive depth of esophageal squamous cell carcinomaEndoscopy 2015; 47(02): 122-128DOI: 10.1055/s-0034-1390858
FRI0084 Autopsy reports of the cerebrum of 24 patients with sle in the period 1988–99
Authors: CF Allaart, MJ Rood, SG Van Duinen, TW Huizinga
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> Clinical manifestations of neurologic involvement in patients with SLE (Neuropsychiatric SLE or NPSLE) may be either due to secundary causes such as antiphospholipid-syndrome associated infarctions or bleedings or infections, or due to primary causes such as immune-mediated vasculitis or cerebritis. Depending on the probable cause, different therapeutic approaches are chosen. <h3>Objectives</h3> Previous reports on histopathologic have suggested that, since it is so seldomly found, cerebral vasculitis cannot be an important cause of neurologic symptoms in SLE. <h3>Methods</h3> <h3>Results</h3> However, a search in the computer archives of PALGA, the foundation that collects all pathology reports from Dutch PA-laboratories, beginning in 1988 and covering all reports since 1990, revealed vasculitis laesions in no less than 5 of 24 cranial autopsies of patients with SLE. In an additional 4, laesions were described that were compatible with remnants of previous vasculitis. <h3>Conclusion</h3> These findings suggest that cerebral vasculitis must be considered as a possible underlying cause of symptoms when it comes to choosing therapy for patients with NPSLE.
The Genomic Selfing Syndrome Accompanies the Evolutionary Breakdown of Heterostyly
Authors: Xin-Jia Wang, Spencer C H Barrett, Li Zhong, Zhi-Kun Wu, De-Zhu Li, Hong Wang, Wei Zhou
Journal: Molecular Biology and Evolution (2020)

The evolutionary transition from outcrossing to selfing can have important genomic consequences. Decreased effective population size and the reduced efficacy of selection are predicted to play an important role in the molecular evolution of the genomes of selfing species. We investigated evidence for molecular signatures of the genomic selfing syndrome using 66 species of Primula including distylous (outcrossing) and derived homostylous (selfing) taxa. We complemented our comparative analysis with a microevolutionary study of P. chungensis, which is polymorphic for mating system and consists of both distylous and homostylous populations. We generated chloroplast and nuclear genomic data sets for distylous, homostylous, and distylous-homostylous species and identified patterns of nonsynonymous to synonymous divergence (dN/dS) and polymorphism (πN/πS) in species or lineages with contrasting mating systems. Our analysis of coding sequence divergence and polymorphism detected strongly reduced genetic diversity and heterozygosity, decreased efficacy of purifying selection, purging of large-effect deleterious mutations, and lower rates of adaptive evolution in samples from homostylous compared with distylous populations, consistent with theoretical expectations of the genomic selfing syndrome. Our results demonstrate that self-fertilization is a major driver of molecular evolutionary processes with genomic signatures of selfing evident in both old and relatively young homostylous populations.
A Functional Screening Strategy for Engineering Chimeric Antigen Receptors with Reduced On-Target, Off-Tumor Activation
Authors: Raphaël B. Di Roberto, Rocío Castellanos-Rueda, Samara Frey, David Egli, Rodrigo Vazquez-Lombardi, Edo Kapetanovic, Jakub Kucharczyk, Sai T. Reddy
Journal: Molecular Therapy (2020)

In recent years, chimeric antigen receptor (CAR) T cell cancer immunotherapies have advanced substantially in the clinic. However, challenges related to safety persist; one major concern occurs when CARs trigger a response to antigen present on healthy cells (on-target, off-tumor response). A strategy to ameliorate this relies on the complex relationship between receptor affinity and signaling, such that one can engineer a CAR that is only activated by tumor cells expressing high antigen levels. Here, we developed a CAR T cell display platform with stable genomic expression and rapid functional screening based on interleukin-2 signaling. Starting with a CAR with high affinity toward its target antigen, we combined CRISPR-Cas9 genome editing and deep mutational scanning to generate a library of antigen-binding domain variants. This library was subjected to multiple rounds of selection based on either antigen binding or cell signaling. Deep sequencing of the resulting libraries and a comparative analysis revealed the enrichment and depletion of specific variants from which we selected CARs that were selectively activated by tumor cells based on antigen expression levels. Our platform demonstrates how directed evolution based on functional screening and deep sequencing-guided selection can be combined to enhance the selectivity and safety of CARs. In recent years, chimeric antigen receptor (CAR) T cell cancer immunotherapies have advanced substantially in the clinic. However, challenges related to safety persist; one major concern occurs when CARs trigger a response to antigen present on healthy cells (on-target, off-tumor response). A strategy to ameliorate this relies on the complex relationship between receptor affinity and signaling, such that one can engineer a CAR that is only activated by tumor cells expressing high antigen levels. Here, we developed a CAR T cell display platform with stable genomic expression and rapid functional screening based on interleukin-2 signaling. Starting with a CAR with high affinity toward its target antigen, we combined CRISPR-Cas9 genome editing and deep mutational scanning to generate a library of antigen-binding domain variants. This library was subjected to multiple rounds of selection based on either antigen binding or cell signaling. Deep sequencing of the resulting libraries and a comparative analysis revealed the enrichment and depletion of specific variants from which we selected CARs that were selectively activated by tumor cells based on antigen expression levels. Our platform demonstrates how directed evolution based on functional screening and deep sequencing-guided selection can be combined to enhance the selectivity and safety of CARs.
Risk factors for hospital admissions related to COVID-19 in patients with autoimmune inflammatory rheumatic diseases
Authors: Dalifer D Freites Nuñez, Leticia Leon, Arkaitz Mucientes, Luis Rodriguez-Rodriguez, Judit Font Urgelles, Alfredo Madrid García, Jose I Colomer, Juan A Jover, Benjamín Fernandez-Gutierrez, Lydia Abasolo
Journal: Annals of the Rheumatic Diseases (2020)

Objectives To describe patients with autoimmune inflammatory rheumatic diseases (AIRD) who had COVID-19 disease; to compare patients who required hospital admission with those who did not and assess risk factors for hospital admission related to COVID-19. Methods An observational longitudinal study was conducted during the pandemic peak of severe acute respiratory syndrome coronavirus 2 (1 March 2020 to 24 April). All patients attended at the rheumatology outpatient clinic of a tertiary hospital in Madrid, Spain with a medical diagnosis of AIRD and with symptomatic COVID-19 were included. The main outcome was hospital admission related to COVID-19. The covariates were sociodemographic, clinical and treatments. We ran a multivariable logistic regression model to assess risk factors for the hospital admission. Results The study population included 123 patients with AIRD and COVID-19. Of these, 54 patients required hospital admission related to COVID-19. The mean age on admission was 69.7 (15.7) years, and the median time from onset of symptoms to hospital admission was 5 (3–10) days. The median length of stay was 9 (6–14) days. A total of 12 patients died (22%) during admission. Compared with outpatients, the factors independently associated with hospital admission were older age (OR: 1.08; p=0.00) and autoimmune systemic condition (vs chronic inflammatory arthritis) (OR: 3.55; p=0.01). No statistically significant findings for exposure to disease-modifying antirheumatic drugs were found in the final model. Conclusion Our results suggest that age and having a systemic autoimmune condition increased the risk of hospital admission, whereas disease-modifying antirheumatic drugs were not associated with hospital admission.
Abstract IA21: Blocking purine synthesis in cancer promotes response to immunotherapy
Authors: Ayelet Erez, Eytan Ruppin, Rom Keshet, Joo Sang Lee
Journal: Cancer Research (2020)

Abstract Nucleotide imbalance promotes mutagenesis in multiple types of cancer. We have previously shown that nucleotide imbalance favoring pyrimidines leads to mutational bias, which promotes the generation of immunogenic neoantigens that respond to ICT. We now find that tumors with high purine bias demonstrate a novel asymmetric genomic signature, consisting of transversion mutations manifested at the DNA, RNA, and protein level. This metabolic alteration leads to presentation of less immunogenic neoantigens and to decreased response to immune checkpoint inhibitors independent of mutational load. Reversing the nucleotide imbalance to favor pyrimidines improves the response to immunotherapy. Our data firmly establish that beyond mutational load and tumor heterogeneity, purine/pyrimidine bias is a strong determinant of the response to immunotherapy. Importantly, our findings suggest that we can metabolically manipulate tumor mutations to improve patients’ response to immunotherapy. Citation Format: Ayelet Erez, Eytan Ruppin, Rom Keshet, Joo Sang Lee. Blocking purine synthesis in cancer promotes response to immunotherapy [abstract]. In: Proceedings of the AACR Special Conference on the Advances in Pediatric Cancer Research; 2019 Sep 17-20; Montreal, QC, Canada. Philadelphia (PA): AACR; Cancer Res 2020;80(14 Suppl):Abstract nr IA21.
MM-013 Phase 2, Multicenter Study of Pomalidomide (POM) Plus Low-Dose Dexamethasone (LoDEX) in Patients (pts) with Relapsed/Refractory Multiple Myeloma (RRMM) and Renal Impairment (RI): Pharmacokinetics (PK) Analysis
Authors: Pieter Sonneveld, Katja C. Weisel, Yan Li, Elisabeth Kueenburg, Shona Collins, Antonia Di Micco, Barbara Rosettani, Pamela Bacon, Meletios A. Dimopoulos
Journal: Blood (2017)
Chemotherapy and Radiation Results in Distinct Patterns of Somatic Mutations in Subsequent Myeloid Disease
Authors: Teodora Kuzmanovic, Tomas Radivoyevitch, Srinivasa Reddy Sanikommu, Bhumika J. Patel, Yasunobu Nagata, Cassandra M. Hirsch, Bartlomiej P. Przychodzen, Sudipto Mukherjee, Anjali S. Advani, Aziz Nazha, Aaron T. Gerds, Hetty E. Carraway, Mikkael A. Sekeres, Jaroslaw P. Maciejewski
Journal: Blood (2017)
Abstract 15399: The Association of Visit-To-Visit Blood Pressure and Blood Glucose Variability and Incidence of Dementia in Patients With Type 2 Diabetes Mellitus: Insights From the Jpad2 Cohort Study
Authors: Chisa Matsumoto, HIsao Ogawa, Yoshihiko Saito, Sadanori Okada, Mio Sakuma, Hirofumi Soejima, Masafumi Nakayama, Naofumi Doi, Hideaki Jinnouchi, Masako Waki, Izuru Masuda, Takeshi Morimoto
Journal: Circulation (2018)

Introduction: Previous studies reported that visit-to-visit blood pressure (BP) variability and blood glucose (Glu) variability were associated with higher risk of cardiovascular disease (CVD) beyo...