tbuckley/cabot-search huggingface dataset:
SUBMUCOSAL TUNNELING ENDOSCOPIC RESECTION (STER) FOR A GIANT ESOPHAGEAL LEIOMYOMA
Authors: S Dharamsi, P Dashatwar, A Bapaye
Journal: Endoscopy (2020)

Introduction STER is recommended for esophageal lesions < 4 cm diameter. Resection of larger lesions is technically challenging. This video-case demonstrates technical nuances of performing STER for large leiomyomas.
The Ventilatory Response to Acute Base Deficit in Humans
Authors: Nathaniel F. Pierce, David S. Fedson, Kenneth L. Brigham, Rupak C. Mitra, R. Bradley Sack, Arabindo Mondal
Journal: Annals of Internal Medicine (2020)

Abstract The time courses of ventilatory response to the development and correction of acute base-deficit acidosis were studied in 35 patients with cholera. In normal controls and during stable bas...
GI symptoms as early signs of COVID-19 in hospitalised Italian patients
Authors: Elisabetta Buscarini, Guido Manfredi, Gianfranco Brambilla, Fernanda Menozzi, Claudio Londoni, Saverio Alicante, Elena Iiritano, Samanta Romeo, Marianna Pedaci, Giampaolo Benelli, Ciro Canetta, Giuseppe La Piana, Guido Merli, Alessandro Scartabellati, Giovanni Viganò, Roberto Sfogliarini, Giovanni Melilli, Roberto Assandri, Daniele Cazzato, Davide Sebastiano Rossi, Susanna Usai, Irene Tramacere, Germano Pellegata, Giuseppe Lauria
Journal: Gut (2020)

suggested by the trend of ICU admissions and deaths, which was lower compared with patients without GI symptoms at onset, the difference proved non-significant.GI manifestations of COVID-19 are early, and possibly isolated, signs of the disease.Patient management and isolation policies should be accordingly tailored.
ENDOSCOPIC SUTURING FOR A CHALLENGING CASE OF A PERSISTENT POST-RADIATION BRONCHO-ESOPHAGEAL FISTULA
Authors: R Palma, R Maselli, VM Ormando, A Fugazza, G Pellegatta, A Anderloni, PA Galtieri, EC Ferrara, M Di Leo, S Carrara, A Repici
Journal: Endoscopy (2020)

Endoscopic suturing is an alternative to surgical treatment for a number of applications in gastrointestinal care.
A SINGLE-CENTRE RETROSPECTIVE STUDY INTO DIAGNOSIS AND MANAGEMENT OF MIRIZZI SYNDROME USING SINGLE-OPERATOR PERORAL CHOLANGIOSCOPY
Authors: G Thomas, H Martin, M Chapman, G Johnson, S Pereira, C Parisinos, T El-Menabawey, G Webster
Journal: Endoscopy (2020)

Aims Mirizzi Syndrome was first described in 1948 and refers to obstruction of the bile duct by impacted gallstones in the cystic duct or gallbladder. Management with conventional ERCP is difficult. We report our single centre experience using single operator cholangioscopy and electrohydraulic lithotripsy.
VETTING BY GENETIC COUNSELLORS IMPROVES APPROPRIATENESS OF COLONOSCOPY FOR PATIENTS ON SURVEILLANCE REGISTER WITH FAMILY HISTORY OF COLORECTAL CANCER
Authors: R Jagdish, N Haslam, A Bassi
Journal: Endoscopy (2020)

Aims The demands for endoscopy have increased and robust vetting of patients on the waiting list for colonoscopy could reduce the waiting lists. In our hospital all patients on the surveillance register are vetted by endoscopists for appropriateness based on information available on the previous reports/referrals. For the patients undergoing surveillance because of family history of colorectal cancer, the vetting team may not have information regarding the full family history or access to the family genetic screening results. For this sub group, we organised a one off vetting by the genetic counsellors from our regional genetics team. The aim was to ensure that these patients are on the correct surveillance schedule.
Randomized Phase III Study of Pemetrexed Plus Cisplatin Versus Vinorelbine Plus Cisplatin for Completely Resected Stage II to IIIA Nonsquamous Non–Small-Cell Lung Cancer
Authors: Hirotsugu Kenmotsu, Nobuyuki Yamamoto, Takeharu Yamanaka, Katsuo Yoshiya, Toshiaki Takahashi, Tsuyoshi Ueno, Koichi Goto, Haruko Daga, Norihiko Ikeda, Kenji Sugio, Takashi Seto, Shinichi Toyooka, Hiroshi Date, Tetsuya Mitsudomi, Isamu Okamoto, Kohei Yokoi, Hideo Saka, Hiroaki Okamoto, Yuichi Takiguchi, Masahiro Tsuboi
Journal: Journal of Clinical Oncology (2020)

PURPOSE To evaluate the efficacy of pemetrexed plus cisplatin versus vinorelbine plus cisplatin as postoperative adjuvant chemotherapy in patients with pathologic stage II-IIIA nonsquamous non–small-cell lung cancer (NSCLC). PATIENTS AND METHODS We performed a randomized, open-label, phase III study at 50 institutions within 7 clinical study groups in Japan. Patients with completely resected pathologic stage II-IIIA (TNM 7th edition) nonsquamous NSCLC were randomly assigned to receive either pemetrexed (500 mg/m 2 , day 1) plus cisplatin (75 mg/m 2 , day 1) or vinorelbine (25 mg/m 2 , days 1 and 8) plus cisplatin (80 mg/m 2 , day 1) with stratification by sex, age, pathologic stage, EGFR mutation, and institution. These treatments were planned to be given every 3 weeks for 4 cycles. The primary end point was recurrence-free survival in the modified intent-to-treat population, excluding ineligible patients. RESULT Between March 2012 and August 2016, 804 patients were enrolled (402 assigned to vinorelbine plus cisplatin and 402 assigned to pemetrexed plus cisplatin). Of 784 eligible patients, 410 (52%) had stage IIIA disease and 192 (24%) had EGFR-sensitive mutations. At a median follow-up of 45.2 months, median recurrence-free survival was 37.3 months for vinorelbine plus cisplatin and 38.9 months for pemetrexed plus cisplatin, with a hazard ratio of 0.98 (95% CI, 0.81 to 1.20; 1-sided P = .474). Grade 3-4 toxicities reported more frequently for vinorelbine plus cisplatin than for pemetrexed plus cisplatin were febrile neutropenia (11.6% v 0.3%, respectively), neutropenia (81.1% v 22.7%, respectively), and anemia (9.3% v 2.8%, respectively). One treatment-related death occurred in each arm. CONCLUSION Although this study failed to show the superiority of pemetrexed plus cisplatin for patients with resected nonsquamous NSCLC, this regimen showed a better tolerability as adjuvant chemotherapy.
RESULTS OF ADDITIONAL SURGERY AFTER ENDOSCOPIC RESECTION FOR T1 COLORECTAL CANCER IN A FRENCH MULTICENTER COHORT
Authors: F Corre, M Barret, JP Ratone, J Albouys, G Rahmi, E Chabrun, JM Canard, M Camus, T Wallenhorst, D Karsenti, M François, R Gerard, J Jacques, B Terris, R Coriat, S Chaussade
Journal: Endoscopy (2020)

Aims A 10% risk of lymph node involvement is associated with submucosal (T1) colorectal carcinomas treated with endoscopic resection, potentially indicating additional surgical resection. The absence of four histological features recalled in the Japanese (JSCCR) and European (ESGE) guidelines allows in case of R0 resection to avoid additional surgery. We aimed to evaluate the results of complementary surgery after endoscopic resection for a T1 colorectal cancer in a Western population.
Supplementation with vitamin D plus calcium reduces fracture risk; vitamin D alone does not
Authors: Anthony A. Donato, Jonathan Nesfeder
Journal: Annals of Internal Medicine (2020)

ACP Journal Club19 May 2020Supplementation with vitamin D plus calcium reduces fracture risk; vitamin D alone does notAnthony A. Donato, MD, MHPE, Jonathan Nesfeder, DOAnthony A. Donato, MD, MHPETower Health/Reading Hospital, Reading, Pennsylvania, USA (A.A.D., J.N.)Search for more papers by this author, Jonathan Nesfeder, DOTower Health/Reading Hospital, Reading, Pennsylvania, USA (A.A.D., J.N.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJ202005190-051 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationYao P, Bennett D, Mafham M, et al. Vitamin D and calcium for the prevention of fracture: a systematic review and meta-analysis. JAMA Netw Open. 2019;2:e1917789. https://pubmed.ncbi.nlm.nih.gov/31860103Clinical Impact RatingsGIM/FP/GP: Public Health: References1 Feng Y, Cheng G, Wang H, Chen B. The associations between serum 25-hydroxyvitamin D level and the risk of total fracture and hip fracture. Osteoporos Int. 2017;28:1641-52. [PMID: 28220196] Google Scholar2 Avenell A, Mak JC, O’Connell D. Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men. Cochrane Database Syst Rev. 2014;(4):CD000227. [PMID: 24729336] Google Scholar3 Saito T, Sterbenz JM, Malay S, et al. Effectiveness of anti-osteoporotic drugs to prevent secondary fragility fractures: systematic review and meta-analysis. Osteoporos Int. 2017;28:3289-300. [PMID: 28770272] Google Scholar4 US Preventive Services Task Force, Grossman DC, Curry SJ, et al. Vitamin D, calcium, or combined supplementation for the primary prevention of fractures in community-dwelling adults. JAMA. 2018;319:1592-9. [PMID: 29677309] Google Scholar Author, Article, and Disclosure InformationAffiliations: Tower Health/Reading Hospital, Reading, Pennsylvania, USA (A.A.D., J.N.)Disclosures: The commentators have disclosed no conflicts of interest. The forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M19-3042.This article was published at Annals.org on -13 May 2020. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 19 May 2020Volume 172, Issue 10Page: JC51KeywordsCalciumOsteoporosisPhosphorusPopulation statisticsPrevention, policy, and public healthProhormonesRisk managementSystematic reviewsVitamin D ePublished: 1 May 2020 Issue Published: 19 May 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
LYNCH SYNDROME CASCADE TESTING; REFERRAL PATTERNS AND TESTING OF FIRST-DEGREE RELATIVES IN A FAMILY SCREENING CLINIC
Authors: T Ryan, S Foy, J Leyden, P MacMathuna, NM Farrelly, M Elsiddig
Journal: Endoscopy (2020)

Aims To examine genetic testing/referral patterns in the first-degree relatives (FDRs) of Lynch Syndrome (LS) patients and assess if all high-risk patients are being captured.
A RETROSPECTIVE ASSESSMENT OF A NEW FRANSEEN-TIP NEEDLE’S DIAGNOSTIC PERFORMANCE AND ITS COMPARISON WITH STANDARD FNA NEEDLES AND WITH PROCORE 20G NEEDLE
Authors: E Dall’Amico, M Bruno, S Gaia, P Cortegoso Valdivia, L Venezia, S Rizza, F Rizzi, M Gesualdo, M Sacco, GM Saracco, CG De Angelis
Journal: Endoscopy (2020)

Aims New biopsy needles for EUS-guided tissue acquisition are gradually replacing traditional FNA needles in clinical practice. We aimed to assess the diagnostic performance and histological diagnostic yield of the new Franseen-tip needle comparing it with Echo-tip FNA needles (20 and 25G) and with ProCore-tip FNB needles (20G).
Rotavirus infection induces glycan availability to promote ileum-specific changes in the microbiome aiding rotavirus virulence
Authors: Melinda A. Engevik, Lori D. Banks, Kristen A. Engevik, Alexandra L. Chang-Graham, Jacob L. Perry, Diane S. Hutchinson, Nadim J. Ajami, Joseph F. Petrosino, Joseph M. Hyser
Journal: Gut Microbes (2020)

Multiple studies have identified changes within the gut microbiome in response to diarrheal-inducing bacterial pathogens. However, examination of the microbiome in response to viral pathogens remains understudied. Compounding this, many studies use fecal samples to assess microbiome composition; which may not accurately mirror changes within the small intestine, the primary site for most enteric virus infections. As a result, the functional significance of small intestinal microbiome shifts during infection is not well defined. To address these gaps, rotavirus-infected neonatal mice were examined for changes in bacterial community dynamics, host gene expression, and tissue recovery during infection. Profiling bacterial communities using 16S rRNA sequencing suggested significant and distinct changes in ileal communities in response to rotavirus infection, with no significant changes for other gastrointestinal (GI) compartments. At 1-d post-infection, we observed a loss in Lactobacillus species from the ileum, but an increase in Bacteroides and Akkermansia, both of which exhibit mucin-digesting capabilities. Concomitant with the bacterial community shifts, we observed a loss of mucin-filled goblet cells in the small intestine at d 1, with recovery occurring by d 3. Rotavirus infection of mucin-producing cell lines and human intestinal enteroids (HIEs) stimulated release of stored mucin granules, similar to in vivo findings. In vitro, incubation of mucins with Bacteroides or Akkermansia members resulted in significant glycan degradation, which altered the binding capacity of rotavirus in silico and in vitro. Taken together, these data suggest that the response to and recovery from rotavirus-diarrhea is unique between sub-compartments of the GI tract and may be influenced by mucin-degrading microbes.
GLUCOSE LEVELS IN EUS-ASPIRATED CYST FLUID HAVE A HIGH ACCURACY FOR THE DIAGNOSIS OF MUCINOUS PANCREATIC CYSTIC LESIONS
Authors: G Rossi, G Capurso, MC Petrone, M Locatelli, S Crippa, C Doglioni, A Mariani, SGG Testoni, L Archibugi, PG Arcidiacono
Journal: Endoscopy (2020)

Aims Differential diagnosis(DD)between mucinous(M) and non-mucinous(NM) pancreatic cystic lesions(PCLs) is fundamental for appropriate patients’management. CEA levels>192 ng/ml are considered suggestive of mucinous cysts(MC), yet with limited accuracy. Recent studies have suggested that low intracystic glucose levels are associated with MC.
Correspondence regarding “T-box protein 4 mutation causing pulmonary arterial hypertension and lung disease”: a single-centre case series
Authors: Samara M.A. Jansen, Lieke van den Heuvel, Lilian J. Meijboom, Suzanne I.M. Alsters, Anton Vonk Noordegraaf, Arjan C. Houweling, Harm Jan Bogaard
Journal: European Respiratory Journal (2020)

<b>A single-centre case series of adult subjects with a TBX4 mutation, in whom two distinctive findings on HRCT (<i>i.e.</i> tracheal and bronchial diverticulosis; irregular bronchial walls) were observed</b>http://bit.ly/2v3s7HE
Hypofibrinogenemic Hemorrhage in Acute Myelogenous Leukemia Treated with Heparin
Authors: William G. Baker, Nils U. Bang, Ralph L. Nachman, Farro Raafat, Herbert I. Horowitz
Journal: Annals of Internal Medicine (2020)

Excerpt Hemorrhage is a frequent complication of acute leukemia. A recent review of acute leukemia presented evidence of bleeding in 66% of 322 cases and showed that it was the principal cause of d...
Fusion 68Ga–Prostate-Specific Membrane Antigen PET/MRI on Postoperative Surveillance of Juvenile Nasal Angiofibroma
Authors: Pirabu Sakthivel, Alok Thakar, Sreedharan Thankarajan Arunraj, Ashu Seith Bhalla, Rakesh Kumar
Journal: Clinical Nuclear Medicine (2020)

Abstract Prostate-specific membrane antigen (PSMA) is expressed universally in juvenile nasopharyngeal angiofibroma (JNA). As contrast enhancement of postoperative scar is common with contrast-enhanced MRI (CEMRI), diagnosis of residual/recurrent JNA remains perplexing. Prostate-specific membrane antigen PET targets only the neovasculature and may aid in resolving this dilemma. Positive contrast enhancement on CEMRI was noted in a patient after 30 years of initial surgery, simulating recurrence. However, there was no abnormal uptake in PSMA scan, which was confirmed by biopsy as postoperative fibrosis. 68 Ga-PSMA PET/MRI fusion may be an easy and novel technique to aid in differentiating residual/recurrent disease from surgical site reparative tissue.
INTERVENTIONAL TRAINING MODEL FOR FLEXIBLE ENDOSCOPY IN POSTOPERATIVELY ALTERED ANATOMY OF THE UPPER GI TRACT
Authors: K Koch, U Schweizer, B Mothes, D Wichmann, KE Grund
Journal: Endoscopy (2020)

Aims Many surgeries in the upper gastrointestinal tract, especially the steadily growing number of bariatric procedures, often result in a fundamentally altered anatomy. Insufficient knowledge of the altered anatomy leads to an increased risk in follow-up endoscopy, for example due to cholelithiasis after bariatric surgery. A realistic, patient-like training model is not yet available, but could improve the quality of diagnostic and, above all, therapeutic endoscopy in patients with postoperatively altered anatomy.
SPYBITE BIOPSY SYSTEM DURING CHOLANGIOSCOPY – LEARNING CURVE AND EXPERIENCES FROM A SINGLE CENTRE, TERTIARY HOSPITAL IN THE UNITED KINGDOM
Authors: N Noor, MG Fonseca, A Komoriyama, G Corbett
Journal: Endoscopy (2020)

Aims Previous small studies have suggested that SpyBite may be superior to cytology brushings and standard forceps biopsies. However, the utility for establishing a biliary diagnosis and the learning process required for this procedure is still unclear. The objective of this study was to investigate the learning process for SpyBite biopsies in a tertiary centre cholangioscopy service.
EVALUATION OF TISSUE OXYGEN SATURATION (STO2) BEFORE AND AFTER CHEMOTHERAPY FOR ADVANCED ESOPHAGEAL CANCER BY OXYGEN SATURATION (OS) IMAGING
Authors: Y Yoda, K Nishihara, H Sunakawa, T Minamide, Y Yamamoto, K Nakajo, T Murano, T Kadota, K Shinmura, H Ikematsu, T Yano
Journal: Endoscopy (2020)

Aims Oxygen saturation (OS) imaging (FUJIFILM Corporation, Tokyo, Japan) is a novel endoscopic technology which can directly measure and visualize the tissue oxygen saturation (StO2) of gastrointestinal tract pixel-by-pixel without any additional drugs. OS imaging is expected to contribute to cancer research which leads to predict the efficacy of anti-cancer treatment. The purpose of this study is to evaluate StO2 and their changes due to chemotherapy in advanced esophageal cancer.
<i>Vital Signs:</i> Postpartum Depressive Symptoms and Provider Discussions About Perinatal Depression — United States, 2018
Authors: Brenda L. Bauman, Jean Y. Ko, Shanna Cox, Denise V. D’Angelo, MPH, Lee Warner, Suzanne Folger, Heather D. Tevendale, Kelsey C. Coy, Leslie Harrison, Wanda D. Barfield
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

Perinatal depression is a complication of pregnancy that can result in adverse maternal and infant outcomes. Screening to identify pregnant and postpartum women with depressive symptoms is recommended to provide diagnosis, treatment, and follow-up care to reduce poor outcomes.CDC analyzed 2018 data from the Pregnancy Risk Assessment Monitoring System to describe postpartum depressive symptoms (PDS) among women with a recent live birth and to assess whether health care providers asked women about depression during prenatal and postpartum health care visits, by site and maternal and infant characteristics.Among respondents from 31 sites, the prevalence of PDS was 13.2%, ranging from 9.7% in Illinois to 23.5% in Mississippi. The prevalence of PDS exceeded 20% among women who were aged ≤19 years, were American Indian/Alaska Native, smoked during or after pregnancy, experienced intimate partner violence before or during pregnancy, self-reported depression before or during pregnancy, or whose infant had died since birth. The prevalence of women reporting that a health care provider asked about depression during prenatal care visits was 79.1% overall, ranging from 51.3% in Puerto Rico to 90.7% in Alaska. The prevalence of women reporting that a provider asked about depression during postpartum visits was 87.4% overall, ranging from 50.7% in Puerto Rico to 96.2% in Vermont.The prevalence of self-reported PDS varied by site and maternal and infant characteristics. Whether providers asked women about perinatal depression was not consistent across sites. Provision of recommended screenings and appropriate referrals for diagnosis, treatment, and follow-up care can ensure early and effective management of depression to reduce adverse maternal and infant outcomes.
Methodological Development of Combination Drug and Radiotherapy in Basic and Clinical Research
Authors: Cyrus Chargari, Antonin Levy, Xavier Paoletti, Jean-Charles Soria, Christophe Massard, Ralph R. Weichselbaum, Eric Deutsch
Journal: Clinical Cancer Research (2020)

Newer technical improvements in radiation oncology have been rapidly implemented in recent decades, allowing an improved therapeutic ratio. The development of strategies using local and systemic treatments concurrently, mainly targeted therapies, has however plateaued. Targeted molecular compounds and immunotherapy are increasingly being incorporated as the new standard of care for a wide array of cancers. A better understanding of possible prior methodology issues is therefore required and should be integrated into upcoming early clinical trials including individualized radiotherapy-drug combinations. The outcome of clinical trials is influenced by the validity of the preclinical proofs of concept, the impact on normal tissue, the robustness of biomarkers and the quality of the delivery of radiation. Herein, key methodological aspects are discussed with the aim of optimizing the design and implementation of future precision drug-radiotherapy trials.
Patient-Centered Decision Making and Health Care Outcomes
Authors: Saul J. Weiner, Alan Schwartz, Gunjan Sharma, Amy Binns-Calvey, Naomi Ashley, Brendan Kelly, Amit Dayal, Sonal Patel, Frances M. Weaver, Ilene Harris
Journal: Annals of Internal Medicine (2013)

Patient-centered decision making is when the physician considers an individual patient's needs and circumstances (that is, the context) when formulating a care plan. This study evaluated audio reco...
RAMAN SPECTROSCOPY CAN DIFFERENTIATE MUCOSAL HEALING FROM NON-HEALING IN INFLAMMATORY BOWEL DISEASE
Authors: S Smith, C Banbury, D Zardo, R Cannatelli, OM Nardone, Uday Shivaji, S Ghosh, PG Oppenheimer, M Iacucci
Journal: Endoscopy (2020)

Aims Mucosal healing is a key treatment target in IBD, and is defined in terms of mucosal and vascular architecture by the recent PICaSSO score. Despite endoscopic evidence of healing, patients still experience early relapse. Raman Spectroscopy describes the scattering of inelastic light giving spectra that is highly specific for individual molecules. Our aim was to establish if Raman Spectroscopy can differentiate between inflammation and mucosal healing.
SERIOUS AND INFREQUENT COMPLICATION AFTER PLACEMENT OF LAMS - AXIOS - IN A REFRACTORY STENOSIS OF ESOPHAGOYEYUNAL ANASTOMOSIS
Authors: SA Lorenzo, AMF López, EB Castro, MG Rivas, AG Gómez, LL Rosés, JAG Ramírez
Journal: Endoscopy (2020)

Placement of LAMS has been described to drain pancreatic collections and has been use to treat refractory gastrointestinal anastomosis.
Racial/Ethnic Bias in Pediatric Care and the Criminalization of Poverty and Race/Ethnicity—Seek and Ye Shall Find
Authors: Benard P. Dreyer
Journal: JAMA Pediatrics (2020)

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