Advising Patients on How to Achieve Long-Term Weight Loss
Authors: Leslie I. Katzel, John D. Sorkin
Journal: Annals of Internal Medicine (2019)

Editorials21 May 2019Advising Patients on How to Achieve Long-Term Weight LossLeslie I. Katzel, MD, PhD and John D. Sorkin, MD, PhDLeslie I. Katzel, MD, PhDBaltimore VA Medical Center Geriatric Research and Education Clinical Center and University of Maryland School of Medicine, Baltimore, Maryland (L.I.K., J.D.S.)Search for more papers by this author and John D. Sorkin, MD, PhDBaltimore VA Medical Center Geriatric Research and Education Clinical Center and University of Maryland School of Medicine, Baltimore, Maryland (L.I.K., J.D.S.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M19-0782 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Approximately 40% of adults are obese, and an additional 32% are overweight (1). Helping overweight and obese patients lose weight and keep it off is a major public health problem. Although some patients are initially successful in losing weight, many regain some if not most of the weight (2). Understanding factors that contribute to long-term weight loss (LTWL) may allow for development of interventions that promote LTWL.In this issue, Apolzan and colleagues (3) report post hoc analyses of predictors of LTWL over 15 years of follow-up in the DPP (Diabetes Prevention Program) (4) and the DPPOS (Diabetes Prevention Program ...References1. Fryar CD, Carroll MD, Ogden CL. Prevalence of Overweight, Obesity, and Severe Obesity Among Adults Aged 20 and Over: United States, 1960–1962 Through 2015–2016. Atlanta: National Center for Health Statistics; 2018. Accessed at https://stacks.cdc.gov/view/cdc/58670 on 27 February 2019. Google Scholar2. Ryan DH, Kahan S. Guideline recommendations for obesity management. Med Clin North Am. 2018;102:49-63. [PMID: 29156187] doi:10.1016/j.mcna.2017.08.006 CrossrefMedlineGoogle Scholar3. Apolzan JW, Venditti EM, Edelstein SL, Knowler WC, Dabelea D, Boyko EJ, et al; Diabetes Prevention Program Research Group. Long-term weight loss with metformin or lifestyle intervention in the Diabetes Prevention Program Outcomes Study. Ann Intern Med. 2019;170:682-90. doi:10.7326/M18-1605 LinkGoogle Scholar4. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, et al; Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346:393-403. [PMID: 11832527] CrossrefMedlineGoogle Scholar5. Knowler WC, Fowler SE, Hamman RF, Christophi CA, Hoffman HJ, Brenneman AT, et al; Diabetes Prevention Program Research Group. 10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. Lancet. 2009;374:1677-86. [PMID: 19878986] doi:10.1016/S0140-6736(09)61457-4 CrossrefMedlineGoogle Scholar6. Aroda VR, Knowler WC, Crandall JP, Perreault L, Edelstein SL, Jeffries SL, et al; Diabetes Prevention Program Research Group. Metformin for diabetes prevention: insights gained from the Diabetes Prevention Program/Diabetes Prevention Program Outcomes Study. Diabetologia. 2017;60:1601-11. [PMID: 28770322] doi:10.1007/s00125-017-4361-9 CrossrefMedlineGoogle Scholar7. Diabetes Prevention Program Research Group. Long-term effects of lifestyle intervention or metformin on diabetes development and microvascular complications over 15-year follow-up: the Diabetes Prevention Program Outcomes Study. Lancet Diabetes Endocrinol. 2015;3:866-75. [PMID: 26377054] doi:10.1016/S2213-8587(15)00291-0 CrossrefMedlineGoogle Scholar8. National Heart, Lung, and Blood Institute. Managing Overweight and Obesity in Adults. Systematic Evidence Review From the Obesity Expert Panel, 2013. Bethesda, MD: National Heart, Lung, and Blood Institute. Accessed at www.nhlbi.nih.gov/sites/default/files/media/docs/obesity-evidence-review.pdf on 24 February 2019. Google Scholar9. Diabetes Prevention Program Outcomes Study (DPPOS) [clinical trial]. Accessed at https://clinicaltrials.gov/ct2/show/study/NCT00038727 on 22 February 2019. Google Scholar Author, Article, and Disclosure InformationAffiliations: Baltimore VA Medical Center Geriatric Research and Education Clinical Center and University of Maryland School of Medicine, Baltimore, Maryland (L.I.K., J.D.S.)Grant Support: Drs. Katzel and Sorkin receive salary support from grant P30 AG028747 from the National Institutes of Health (NIH). Dr. Sorkin also receives salary support from NIH grant P30 DK072488.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M19-0782.Corresponding Author: Leslie I. Katzel, MD, PhD, Baltimore VA Medical Center Geriatric Research Education and Clinical Center, 10 North Greene Street (BT/18/GR), Baltimore, MD 21201; e-mail, [email protected]umaryland.edu.Current Author Addresses: Dr. Katzel: Baltimore VA Medical Center Geriatric Research and Education Clinical Center, 10 North Greene Street (BT/18/GR), Baltimore, MD 21201.Dr. Sorkin: Division of Gerontology, Baltimore VA Medical Center Geriatric Research and Education Clinical Center, 10 North Greene Street (BT/18/GR), Baltimore, MD 21201.This article was published at Annals.org on 23 April 2019. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoLong-Term Weight Loss With Metformin or Lifestyle Intervention in the Diabetes Prevention Program Outcomes Study John W. Apolzan , Elizabeth M. Venditti , Sharon L. Edelstein , William C. Knowler , Dana Dabelea , Edward J. Boyko , Xavier Pi-Sunyer , Rita R. Kalyani , Paul W. Franks , Preethi Srikanthan , Kishore M. Gadde , and Metrics 21 May 2019Volume 170, Issue 10Page: 724-725KeywordsDiabetes preventionExerciseGeriatricsHeartInterleukinsLungsMedical educationOverweightPrevention, policy, and public healthWeight loss ePublished: 23 April 2019 Issue Published: 21 May 2019 PDF downloadLoading ...