tbuckley/cabot-search huggingface dataset:
Vitamin B<sub>12</sub> Therapy in Older Adults and Misconception of Its Inappropriateness
Authors: Johan Frederik Håkonsen Arendt, Ebba Nexo
Journal: JAMA Internal Medicine (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Role of Echocardiography and Cardiac Biomarkers in Early Detection of Hematopoietic Stem Cell Transplantation Associated Cardiotoxicity
Authors: Ana Carolina Oliver, Roberto Superchi, Superchi Federico, Canabal Matilde, Jubin Silvana, Carolina Errecarte, Caneiro Ada, Silvia Pierri, Sebastian Galeano, Eloisa Riva, Bello Laura, Regis Gai, Miller Andrew, Pablo J. Muxi, Ricardo Fabian Mosquera
Journal: Blood (2019)
T-Cell Reconstitution after Unrelated Donor HSCT Using Immunotherapy with CD25/71 Allodepleted Donor T Cells: Results of the Randomised Icat Study
Authors: Karl S Peggs, Sarah J Albon, Catherine Irving, Rachel Richardson, Joan Casanovas-Company, Rebecca Wallace, Aleks Guvenel, Sara Ghorashian, Angela Collura, Meera Subramaniyam, Barry Flutter, Bilyana Popova, Fernanda Castro, Andre Lopes, Kim Champion, Oliver Schofield, Laura Clifton-Hadley, Thomas Taylor, Timothy Pulham, Stuart Ings, Robert Herlihy, Maria Farrell, Rachael Wilding, Wendy Ogden, Stuart Adams, Gulrukh Ahsan, Kimberly C Gilmour, Stephen Mackinnon, Eleni Tholouli, Persis J Amrolia
Journal: Blood (2019)
IMMU-37. SINGLE-CELL SYSTEMS NEUROIMMUNOLOGY REVEALS IMMUNOSUPPRESSIVE CORRELATES WITH VENTRICULAR STEM CELL NICHE CONTACT IN HUMAN GLIOBLASTOMA
Authors: Todd Bartkowiak, Sierra Barone, Allison Greenplate, Justine Sinnaeve, Nalin Leelatian, Akshitkumar Mistry, Caroline Roe, Bret Mobley, Lola Chambless, Reid Thompson, Kyle Weaver, Rebecca Ihrie, Jonathan Irish
Journal: Neuro-Oncology (2019)

Abstract Glioblastomas make up more than 60% of adult primary brain tumors and carry a median survival of less than 15 months despite aggressive standard therapy. Immunotherapy, which is now standard of care for many solid tumors, offers an appealing therapeutic approach that may improve outcomes for glioblastoma patients. Predictive features in glioblastomas that may inform responsiveness to different immunotherapeutic modalities, however, are still lacking. Recent studies have demonstrated that patients whose tumors show radiographic contact with the lateral ventricles, and thus the stem cell niche of the ventricular-subventricular zone (V-SVZ), have reduced survival outcomes compared to patients whose tumors do not contact the V-SVZ. We therefore hypothesized that tumor contact with the V-SVZ engenders a unique, immunosuppressive microenvironment that promotes tumor growth by suppressing anti-tumor immunity. Glioblastoma tumors, obtained in accordance with the Declaration of Helsinki and with institutional IRB approval (#131870, #030372, #181970), were disaggregated into single-cell suspensions and multi-dimensional single-cell mass cytometry was performed to interrogate &gt;30 immune parameters in thirteen immune populations infiltrating human glioblastomas. Using advanced computational dimensionality-reduction tools (Citrus, t-SNE, FlowSOM, and MEM), we identified distinctions among the abundance and phenotypes of tumor-infiltrating immune cells. Firstly, on the basis of tumor contact with the V-SVZ, Citrus identified differential abundance of five T and myeloid cell subsets among glioblastomas. Secondly, differential expression of five functional immune markers was observed in seven distinct immune cell subsets infiltrating glioblastoma tumors. Further, both immune abundance and marker expression correlated with patient outcome. Manual gating analysis and parallel computational pipelines confirmed that comparable cell subsets could be identified with traditional approaches and unsupervised algorithmic analysis. These results provide key insights into the immune microenvironment of glioblastomas. In addition, several clinically actionable immunotherapeutic targets were uncovered that may be used to optimize treatment strategies for glioblastomas based on V-SVZ contact status.
Polygenic Risk Score Contribution to Psychosis Prediction in a Target Population of Persons at Clinical High Risk
Authors: Diana O. Perkins, Loes Olde Loohuis, Jenna Barbee, John Ford, Clark D. Jeffries, Jean Addington, Carrie E. Bearden, Kristin S. Cadenhead, Tyrone D. Cannon, Barbara A. Cornblatt, Daniel H. Mathalon, Thomas H. McGlashan, Larry J. Seidman, Ming Tsuang, Elaine F. Walker, Scott W. Woods
Journal: American Journal of Psychiatry (2019)

The 2-year risk of psychosis in persons who meet research criteria for a high-risk syndrome is about 15%-25%; improvements in risk prediction accuracy would benefit the development and implementation of preventive interventions. The authors sought to assess polygenic risk score (PRS) prediction of subsequent psychosis in persons at high risk and to determine the impact of adding the PRS to a previously validated psychosis risk calculator.
Treosulfan Metabolite (S, S-EBDM) Pharmacokinetics Influences Regimen Related Toxicity in Patients with Beta Thalassaemia Major Undergoing HSCT
Authors: Aswin Anand PAI, John C Panetta, Ezhil Pavai Mohanan, Raveen Stephen Stallon Illangeswaran, Balaji Balakrishnan, Eunice Sindhuvi Edison, Kavitha M Lakshmi, Uday Prakash Kulkarni, Anup Joseph Devasia, Fouzia N., Anu Korula, Aby Abraham, Biju George, Vikram Mathews, Alok Srivastava, Poonkuzhali Balasubramanian
Journal: Blood (2019)
Updated Progression-Free Survival (PFS) and Overall Survival (OS) with Melflufen and Dexamethasone in Patients with Relapsed/Refractory Multiple Myeloma (RRMM): Results from the Phase 2 Study O-12-M1
Authors: Sara Bringhen, Peter M. Voorhees, Torben Plesner, Ulf-Henrik Mellqvist, Brandi Reeves, Pieter Sonneveld, Catriona Byrne, Eva Nordström, Johan Harmenberg, Jakob Obermüller, Paul G. Richardson
Journal: Blood (2019)
How many rare diseases are there?
Authors: Melissa Haendel, Nicole Vasilevsky, Deepak Unni, Cristian Bologa, Nomi Harris, Heidi Rehm, Ada Hamosh, Gareth Baynam, Tudor Groza, Julie McMurry, Hugh Dawkins, Ana Rath, Courtney Thaxton, Giovanni Bocci, Marcin P. Joachimiak, Sebastian Köhler, Peter N. Robinson, Chris Mungall, Tudor I. Oprea
Journal: Nature Reviews Drug Discovery (2019)
A Phase Ib/II Study of the Histone Methyltransferase Inhibitor Pinometostat in Combination with Azacitidine in Patients with 11q23-Rearranged Acute Myeloid Leukemia
Authors: Kamal Menghrajani, Sheng F Cai, Sean M. Devlin, Scott A. Armstrong, Richard Piekarz, Michelle Rudek, Martin S. Tallman, Eytan M. Stein
Journal: Blood (2019)
Sociodemographic and Clinical Characteristics Associated with Patient's Decision to Refuse Multiple Myeloma (MM) Treatment, and Its Impact on Outcomes
Authors: Vivek Kumar, Mays F Abdulazeez, Srilekha Bodepudi, Suman Biswas, Vivek Roy, Taimur Sher, Meghna Ailawadhi, Victoria R. Alegria, Aneel Paulus, Asher A. Chanan-Khan, Sikander Ailawadhi
Journal: Blood (2019)
Combined Point of Care Tools Are Able to Improve Treatment Adherence and Health-Related Quality of Life in Patients with Severe Hemophilia: An Observational Prospective Study
Authors: Mariasanta Napolitano, Simona Raso, Maria Francesca Mansueto, Salvatrice Mancuso, Matteo Nicola Dario Di Minno, Dalila Scaturro, Giulia Letizia Mauro, Giovanni Di Minno, Sergio Siragusa
Journal: Blood (2019)
Prognostic Significance of Interim PET/CT Assessment for the Treatment of Advanced Stage of Marginal Zone Lymphoma in the Post Immunochemotherapy Era
Authors: Ga-Young Song, Seok Jin Kim, Sang Eun Yoon, Jin Seok Kim, Ho-Young Yhim, Youngil Koh, Sung Yong Oh, Ho Sup Lee, Ho-Jin Shin, Young Rok Do, Won Sik Lee, Lee Gyeong-Won, Dae Sik Kim, Yong Park, Deok-Hwan Yang
Journal: Blood (2019)
Developmental DNA Methylation Subtype Predicts Progression to Treatment and Survival in High-Count Monoclonal B Lymphocytosis
Authors: Brian Giacopelli, Kari G. Chaffee, Yue-zhong Wu, John C. Byrd, Tait D. Shanafelt, Sameer A. Parikh, Esteban Braggio, Susan L. Slager, Neil E. Kay, Christopher C. Oakes
Journal: Blood (2019)
Outcomes of HIV-Associated Burkitt Lymphoma in Brazil: High Treatment Toxicity and Refractoriness Rates - a Multicenter Cohort Study
Authors: Wellington F Silva, Pedro Marques Garibaldi, Lidiane Inês Da Rosa, Marcelo Bellesso, Diego V Clé, Marcia Torresan Delamain, Eduardo M Rego, Juliana Pereira, Vanderson Rocha
Journal: Blood (2019)
Machine Learning Unveils Proteotypic Mimicry in Genetically Defined SCN Variants
Authors: Sebastian Hesse, Christoph Klein, Rappsilber Juri, Yoko Mizoguchi, Monika Linder, Piotr Grabowski, Zahra Alizadeh, Zahra Pourpak, Nima Rezaei, Sorin Iurian, Ekrem Unal, Fabian Hauck, Ralf Zimmer, Gergely Csaba
Journal: Blood (2019)
Evaluation of commonly used analysis strategies for epigenome- and transcriptome-wide association studies through replication of large-scale population studies
Authors: Jeroen van Rooij, Pooja R. Mandaviya, Annique Claringbould, Janine F. Felix, Jenny van Dongen, Rick Jansen, Lude Franke, Peter A. C. ’t Hoen, Bas Heijmans, Joyce B. J. van Meurs
Journal: Genome biology (2019)

Abstract Background A large number of analysis strategies are available for DNA methylation (DNAm) array and RNA-seq datasets, but it is unclear which strategies are best to use. We compare commonly used strategies and report how they influence results in large cohort studies. Results We tested the associations of DNAm and RNA expression with age, BMI, and smoking in four different cohorts ( n = ~ 2900). By comparing strategies against the base model on the number and percentage of replicated CpGs for DNAm analyses or genes for RNA-seq analyses in a leave-one-out cohort replication approach, we find the choice of the normalization method and statistical test does not strongly influence the results for DNAm array data. However, adjusting for cell counts or hidden confounders substantially decreases the number of replicated CpGs for age and increases the number of replicated CpGs for BMI and smoking. For RNA-seq data, the choice of the normalization method, gene expression inclusion threshold, and statistical test does not strongly influence the results. Including five principal components or excluding correction of technical covariates or cell counts decreases the number of replicated genes. Conclusions Results were not influenced by the normalization method or statistical test. However, the correction method for cell counts, technical covariates, principal components, and/or hidden confounders does influence the results.
Transcutaneous electrical acupoint stimulation for preventing postoperative nausea and vomiting after general anesthesia: A meta-analysis of randomized controlled trials
Authors: Jiabao Chen, Qing Tu, Shuai Miao, Zhenfeng Zhou, Shuangfei Hu
Journal: International Journal of Surgery (2019)

We performed this meta-analysis to evaluate the effectiveness of transcutaneous electrical acupoint stimulation (TEAS) for preventing postoperative nausea and vomiting (PONV) after general anesthesia.We searched PubMed, EMbase, Ovid, Web of Science for relevant randomized controlled trials (RCTs) about TEAS for the prevention of PONV, published through July 31, 2019. The primary outcome was the incidence of PONV, postoperative nausea (PON) and postoperative vomiting (POV) recorded within 24 h after surgery. Secondary outcomes included the numbers of patients needing antiemetic rescue and the incidence of postoperative adverse effects referred to general anesthesia. Data were pooled and analyzed by RevMan 5.3 software.Fourteen RCTs (1653 participants) were included in this meta-analysis. The current results suggested that application of TEAS showed obvious superiority in lower incidence of PONV (relative risk [RR] 0.54, 95% confidence interval [CI] 0.42 to 0.68, P < 0.0001), PON (RR, 0.59, 95% CI 0.49 to 0.71, P < 0.0001), POV (RR 0.46; 95% CI, 0.33 to 0.65, P < 0.0001), lower numbers of patients needing antiemetic rescue (RR 0.56, 95% CI 0.40 to 0.78, P = 0.0005), lower incidence of dizziness (RR 0.43, 95% CI 0.31 to 0.60, P < 0.0001) and pruritus (RR 0.43, 95% CI 0.31 to 0.58, P = 0.02), compared with controlled intervention.TEAS is a reasonable modality to incorporate into a multimodal management approach for the prevention of PONV, PON, POV and associated with lower numbers needing antiemetic rescue, lower incidence of adverse effects after general anesthesia.
Recent Advances in Hemostasis at the Nanoscale
Authors: Xiao‐Xiong Wang, Qi Liu, Jin‐Xia Sui, Seeram Ramakrishna, Miao Yu, Yu Zhou, Xing‐Yu Jiang, Yun‐Ze Long
Journal: Advanced Healthcare Materials (2019)

Rapid and effective hemostatic materials have received wide attention not only in the battlefield but also in hospitals and clinics. Traditional hemostasis relies on materials with little designability which has many limitations. Nanohemostasis has been proposed since the use of peptides in hemostasis. Nanomaterials exhibit excellent adhesion, versatility, and designability compared to traditional materials, laying a good foundation for future hemostatic materials. This review first summarizes current hemostatic methods and materials, and then introduces several cutting-edge designs and applications of nanohemostatic materials such as polypeptide assembly, electrospinning of cyanoacrylate, and nanochitosan. Particularly, their advantages and working mechanisms are introduced. Finally, the challenges and prospects of nanohemostasis are discussed.
Aging influences cerebrovascular myogenic reactivity and BK channel function in a sex-specific manner
Authors: Joseph T Reed, Tanya Pareek, Srinivas Sriramula, Mallikarjuna R Pabbidi
Journal: Cardiovascular Research (2019)

The myogenic reactivity of the middle cerebral arteries (MCA) protects the brain by altering the diameter in response to changes in lumen pressure. Large conductance potassium (BK) channels are known to regulate the myogenic reactivity, yet, it is not clear how aging alters the myogenic reactivity via the BK channel in males and females. Thus, we hypothesize that age-associated changes in BK channel subunits modulate the myogenic reactivity in a sex-specific manner.We used vascular reactivity, patch-clamp, and biochemical methods to measure myogenic reactivity, BK channel function, and expression, respectively in cerebral vessels of adult and aged male and female Sprague Dawley rats. Our results suggest that aging and ovariectomy (OVX) exaggerated the myogenic reactivity of MCA in females but attenuated it in males. Aging induced outward eutrophic remodelling in females but inward hypertrophic remodelling in males. Aging decreased total, Kv, BK channel currents, and spontaneous transient outward currents (STOC) in vascular smooth muscle cells isolated from females, but not in males. Aging increased BKα subunit mRNA and protein both in males and females. However, aging decreased BKβ1 subunit protein and mRNA in females only. In males, BKβ1 mRNA is increased, but protein is decreased. Iberiotoxin-induced MCA constriction is lower in aged females but higher in aged males. Activation of BKα (10 µM NS1619) and BKβ1 (10 µM S-Equol) subunits failed to increase STOCs and were unable to decrease the myogenic reactivity of MCA in aged female but not in aged male rats. OVX decreased, but chronic supplementation of oestradiol restored BK channel expression and function.Overall our results suggest that aging or OVX-associated downregulation of the BKβ1 expression and function in females results in exaggerated myogenic reactivity of MCA. However, age-associated increase in BK channel function in males attenuated myogenic reactivity of MCA.
Inv(16) AML Engrafts Human Cytokine Knock-in Mice
Authors: Philipp J Rauch, Jana M Ellegast, Larisa V Kovtonyuk, Ulrich Wagner, Rouven Müller, Yasuyuki Saito, Nicole Wildner-Verhey van Wijk, Christine Fritz, Anahita Rafiei, Veronika Lysenko, Ewa Dudkiewicz, Davide Soldini, Jeroen S Goede, Richard Flavell, Markus G Manz
Journal: Blood (2016)
Mechanisms regulating PD-L1 expression on tumor and immune cells
Authors: Shuming Chen, George A. Crabill, Theresa S. Pritchard, Tracee L. McMiller, Ping Wei, Drew M. Pardoll, Fan Pan, Suzanne L. Topalian
Journal: Journal for ImmunoTherapy of Cancer (2019)

The PD-1/PD-L1 checkpoint is a central mediator of immunosuppression in the tumor immune microenvironment (TME) and is primarily associated with IFN-g signaling. To characterize other factors regulating PD-L1 expression on tumor and/or immune cells, we investigated TME-resident cytokines and the role of transcription factors in constitutive and cytokine-induced PD-L1 expression.
Geno-Clinical Model for the Diagnosis of Bone Marrow Myeloid Neoplasms
Authors: Cameron Beau Hilton, Manja Meggendorfer, Mikkael A. Sekeres, Jacob Shreve, Nathan Radakovich, Yazan Rouphail, Wencke Walter, Stephan Hutter, Eric Padron, Michael R. Savona, Aaron T. Gerds, Sudipto Mukherjee, Brianna N Smith, Yasunobu Nagata, Cassandra M. Hirsch, Rami S. Komrokji, Babal K. Jha, Claudia Haferlach, Jaroslaw P. Maciejewski, Torsten Haferlach, Aziz Nazha
Journal: Blood (2019)
Comparative Genomic Analyses Defines Shared and Unique Features of cHL and PMBL and New Mechanisms of Sensitivity to PD-1 Blockade
Authors: Kirsty Wienand, Bjoern Chapuy, Chip Stewart, Andrew Dunford, David Wu, Jaegil Kim, Atanas Kamburov, Timothy Wood, Fathima Zumla Cader, Matthew D. Ducar, Aaron R. Thorner, Anwesha Nag, Gabriel K Griffin, Pei-Hsuan Chen, Alexander T Heubeck, Michael J Buonopane, Kamil Bojarczuk, Claire McEwen Cote, Lee N. Lawton, Philippe Armand, Scott J Rodig, Jonathan R. Fromm, Gad Getz, Margaret A. Shipp
Journal: Blood (2019)
Use of Thymoglobulin with Lower Dose of Busulfan Results in Less Acute Gvhd Following Unrelated Donor Allogeneic Stem Cell Transplantation for AML without Affecting Relapse-Free and Overall Survival
Authors: Dipenkumar Modi, Vijendra Singh, Seongho Kim, Abhinav Deol, Asif Alavi, Lois Ayash, Andrew Kin, Voravit Ratanatharathorn, Joseph P. Uberti
Journal: Blood (2019)
Clustering of Transcriptomic Signatures in Newly Diagnosed Diffuse Large B-Cell Lymphoma Identifies Two High-Risk Subgroups Which Increase in Prevalence at Relapse
Authors: Maria Ortiz, Kerstin Wenzl, Matthew Stokes, C. Chris Huang, Matthew J. Maurer, Fadi Towfic, Patrick R. Hagner, Alexander Ratushny, Mark McConnell, Samuel A Danziger, Nicholas Stong, Sneh Lata, Sitharthan Kamalakaran, Konstantimos Mavrommatis, Matthew Trotter, Rebecca L. King, Brian K. Link, Susan L. Slager, Yan Asmann, Myron Czuczman, Stephen M Ansell, James R. Cerhan, Grzegorz Nowakowski, Thomas M. Habermann, Anita K Gandhi, Anne J Novak
Journal: Blood (2019)
Hematopoietic Cell Transplantation Donor Selection Reimagined: KIR-KIR Ligand Interactions and a Formalized Donor Risk Index Effective at Predicting Survival
Authors: Elizabeth Krieger, Urmila Sivagnanaling, Katherine Webb, Dana Broadway, Catherine Roberts, John M. McCarty, Christina M. Wiedl, Rizwan Romee, Armand Keating, Rehan Qayyum, Amir Ahmed Toor
Journal: Blood (2019)
CMET-10. INTRACRANIAL SOLITARY PITUITARY METASTASIS: THE IMPLICATIONS FROM FIVE CASES
Authors: Changguo Shan, Weiping Hong, Mingyao Lai, Hui Wang, Linbo Cai
Journal: Neuro-Oncology (2019)

Abstract BACKGROUND Pituitary gland metastasis is a rare disease which represents only 1% of pituitary gland lesions. Intracranial solitary pituitary metastasis tends to be misdiagnosed as pituitary adenoma, resulting in a delayed anti-tumor treatment. METHODS Five cases of patients with pituitary gland metastasis recorded between 2014 and 2018 in our hospital were investigated with reference to patient demographics, symptoms at presentation, radiological and histological findings, management and outcomes. RESULTS Five patients (4 male and 1 female) were included and the median age was 48 years (range: 21 to 66). In those five cases, central nervous system related symptoms were the first sign of malignancy, including visual loss (5 in 5 patients), visual field defects (5 in 5 patients), apituitarism (5 in 5 patients), headache (4 in 5 patients), hypothroidism (4 in 5 patients) and diabetes insipidus (2 in 5 patients). All patients received total or partial hypophysectomy and pathologically revealed metastatic adenocarcinoma in 4 patients and metastatic squamous carcinoma in 1 patient. Further examinations by Computed Tomography (CT) or Positron Emission Computed Tomography (PET) indicated lung as primary site in five cases. EGFR mutation and ROS1 fusion were found in 3 and 1 adenocarcinoma patient, respectively, through gene detection of tissue. Postoperative radiotherapy (5 patients), target therapy (4 patients) and chemotherapy (1 patient) were given as subsequent treatment. During the follow-up, four patients died and the overall survival was 2, 8, 28 and 30 months, respectively. CONCLUSION We found that pituitary symptoms usually presented as the first sign of malignancy in intracranial solitary pituitary metastasis. Lung is the most frequently primary site, particularly in adenocarcinoma with driver gene mutation. Patients may benefit from multidiscipline treatment, including resection of pituitary metastasis combined with radiotherapy and targeted therapy.