tbuckley/cabot-search huggingface dataset:
Engineered Niches to Analyze Mechanisms of Metastasis and Guide Precision Medicine
Authors: Aaron H. Morris, Sophia M. Orbach, Grace G. Bushnell, Robert S. Oakes, Jacqueline S. Jeruss, Lonnie D. Shea
Journal: Cancer Research (2020)

Cancer metastasis poses a challenging problem both clinically and scientifically, as the stochastic nature of metastatic lesion formation introduces complexity for both early detection and the study of metastasis in preclinical models. Engineered metastatic niches represent an emerging approach to address this stochasticity by creating bioengineered sites where cancer can preferentially metastasize. As the engineered niche captures the earliest metastatic cells at a nonvital location, both noninvasive and biopsy-based monitoring of these sites can be performed routinely to detect metastasis early and monitor alterations in the forming metastatic niche. The engineered metastatic niche also provides a new platform technology that serves as a tunable site to molecularly dissect metastatic disease mechanisms. Ultimately, linking the engineered niches with advances in sensor development and synthetic biology can provide enabling tools for preclinical cancer models and fosters the potential to impact the future of clinical cancer care.
ENDOSCOPIC SUBMUCOSAL DISSECTION OF UPPER AND LOWER GASTROINTESTINAL LESIONS IN A SINGLE WESTERN CENTER: A DESCRIPTIVE, STEP-UP APPROACH
Authors: B Petrik, A Martínez-Alcalá, T Kröner, S Abe, Y Saito, K Mönkemüller
Journal: Endoscopy (2020)

Aims: Background Endoscopic submucosal dissection has been adopted in Asia and Europe. However, there is lack of data on its implementation and usefulness in the United States.
Bedside Optic Nerve Ultrasonography for Diagnosing Increased Intracranial Pressure
Authors: Alex Koziarz, Siddharth Nath, Saleh A. Almenawer
Journal: Annals of Internal Medicine (2020)

Letters2 June 2020Bedside Optic Nerve Ultrasonography for Diagnosing Increased Intracranial PressureAlex Koziarz, MSc, Siddharth Nath, MD, PhD, and Saleh A. Almenawer, MDAlex Koziarz, MScUniversity of Toronto, Toronto, Ontario, Canada (A.K.), Siddharth Nath, MD, PhDMcGill University, Montreal, Quebec, Canada (S.N.), and Saleh A. Almenawer, MDMcMaster University, Hamilton, Ontario, Canada (S.A.A.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L20-0078 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Riveros and colleagues raise excellent points about the safety of optic nerve ultrasonography when diagnosing patients with increased intracranial pressure. We noted in our review that no studies reported these complications when we reviewed the 71 prospective studies included in our meta-analysis. However, we agree with Dr. Riveros and colleagues and caution clinicians about these rare complications related to ultrasonography. Author, Article, and Disclosure InformationAffiliations: University of Toronto, Toronto, Ontario, Canada (A.K.)McGill University, Montreal, Quebec, Canada (S.N.)McMaster University, Hamilton, Ontario, Canada (S.A.A.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M19-0812. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoBedside Optic Nerve Ultrasonography for Diagnosing Increased Intracranial Pressure Alex Koziarz , Niv Sne , Fraser Kegel , Siddharth Nath , Jetan H. Badhiwala , Farshad Nassiri , Alireza Mansouri , Kaiyun Yang , Qi Zhou , Timothy Rice , Samir Faidi , Edward Passos , Andrew Healey , Laura Banfield , Mark Mensour , Andrew W. Kirkpatrick , Aussama Nassar , Michael G. Fehlings , Gregory W.J. Hawryluk , and Saleh A. Almenawer Bedside Optic Nerve Ultrasonography for Diagnosing Increased Intracranial Pressure Toni Riveros , Alex Vengerovsky , and James Town Metrics Cited byA Review of the Methods of Non-Invasive Assessment of Intracranial Pressure through Ocular MeasurementFixed, Dilated, and Conversing—Unreactive Pupil With Preserved Consciousness Indicating Acutely Rising Intracranial Pressure due to Traumatic Intraparenchymal Contusions: Case Report and Review of the LiteratureReal-Time Evaluation of Optic Nerve Sheath Diameter (ONSD) in Awake, Spontaneously Breathing Patients 2 June 2020Volume 172, Issue 11Page: 772KeywordsDisclosureOptic nerveProspective studiesSafetyUltrasound imaging ePublished: 2 June 2020 Issue Published: 2 June 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
CLOSURE OF DUODENAL FISTULA IN 10 DAYS WITH ENDOSCOPIC VACUUM THERAPY (EVT)
Authors: F Galetti, CO Matsubayashi, AC Madruga-Neto, RH Resende, DTH de Moura, R Tahmasebi, FS de Medeiros, SE Matuguma, MEL dos Santos, EGH de Moura
Journal: Endoscopy (2020)

Results 81-year-old female underwent laparoscopic left hemicolectomy for colon neoplasm. After 2 days she underwent duodeno-jejunal segmental resection with duodeno-jejunal anastomosis for generalized peritonitis. 25 days later the endoscopy showed a transmural defect. EVT was performed. Ten days later a significant decrease in the size of the defect was observed, without extravasation of the contrast in fluoroscopy resulted in the closure of the duodenal fistula.
ENDOSCOPIC-ULTRASOUND (EUS)-DIRECTED TRANSGASTRIC ERCP (EDGE) PROCEDURE FOR THE MANAGEMENT OF CHOLEDOCHOLITHIASIS FOLLOWING ROUX-EN-Y GASTRIC BYPASS
Authors: F Rana, M Ishtiaq, S Everett, B Paranandi, M Huggett
Journal: Endoscopy (2020)

Aims The obesity epidemic and resultant growth in bariatric surgery have led to a unique problem of managing pancreaticobiliary diseases in patients with altered anatomy, particularly after Roux-en-Y gastric bypass (RYGB). Various techniques including enteroscopy-assisted [1] and laparoscopy/laparotomy-assisted [2,3] endoscopic retrograde cholangiopancreatography (ERCP) have been developed to address this problem with varying success. More recently, a novel endoscopic-ultrasound (EUS)-directed transgastric ERCP (EDGE) procedure has been described4. Here we present what the authors believe are the first five EDGE procedures performed in the United Kingdom.
SALINE-IMMERSION THERAPEUTIC ENDOSCOPY (SITE) ASSISTED POCKET-CREATION METHOD (PCM) ENDOSCOPIC SUBMUCOSAL DISSECTION (ESD) OF A CIRCUMFERENTIAL 11 × 8 CM RECTOSIGMOID COLORECTAL TUMOUR
Authors: EJ Despott, C Coppo, N Lazaridis, D Costa, R Raymond, A Skamnelos, N Koukias, A Murino
Journal: Endoscopy (2020)

In our institution, pocket-creation-method(PCM) for endoscopic-submucosal-dissection(ESD), is combined with saline-immersion-therapeutic-endoscopy(SITE); this further facilitates PCM-ESD by improving view quality (through refractive magnification and minimal lense fogging) and lesion lifting (through buoyancy).
SINGLE OTSC CLIP IS SUPERIOR COMPARED TO STANDARD THERAPY FOR ACUTE UPPER GI BLEEDING IN LARGE UK SERIES- IS IT TIME TO CHANGE?
Authors: I Rahman, P Duarte, T Hollingworth, P Boger, P Patel
Journal: Endoscopy (2020)

Aims To determine whether the use of the OTSC was associated with lower upper GI haemorrhage rebleeding rates and mortality in the UK.
A COMPREHENSIVE SYSTEMATIC REVIEW AND META-ANALYSIS OF RISK FACTORS FOR REBLEEDING FOLLOWING DEVICE-ASSISTED ENTEROSCOPY THERAPY OF SMALL-BOWEL VASCULAR LESIONS
Authors: E Pérez-Cuadrado-Robles, G Perrod, T Moreels, LEZ Nava, G Blanco, PE Delgado, E Samaha, OVH Mondragón, G Rahmi, C Cellier
Journal: Endoscopy (2020)

Aims To determine the risk factors for rebleeding following device-assisted enteroscopy therapy of small bowel vascular lesions.
Abstract 16204: High Cardiovascular Disease Risk in Sexual Minority Women
Authors: Billy A Caceres, Ab Brody, Perry Halkitis, Caroline Dorsen, Gary Yu, Deborah A Chyun
Journal: Circulation (2017)

Introduction: Sexual minority - lesbian and bisexual - women (SMW) experience significant discrimination and marginalization, which may increase their cardiovascular disease (CVD) risk. The purpose...
LUMEN-APPOSING METAL STENTS (LAMS) VERSUS FULLY COVERED SELF-EXPANDABLE METAL STENT (SEMS) IN ENDOSCOPIC ULTRASOUND-GUIDED CHOLEDOCHODUODENOSTOMY (EUS-CDS) FOR DISTAL MALIGNANT BILIARY OBSTRUCTION (DMBO)
Authors: RN Muñoz, E Valenzuela, JT Tejada, JG Alonso, AC López, MDB Sanz, RSO Hernández, C De la Serna Higuera, MPM Castillo
Journal: Endoscopy (2020)

Aims EUS-CDS is an alternative to PTBD in unresectable distal MBO after failed ERCP. Electrocautery enhanced delivery system (EC-LAMS) facilitates access to the target lumen simplifying the classic multi-step procedure of EUS-CDS. It is unknown if LAMS improve results obtained with SEMS. We sought to compare LAMS vs SEMS for EUS-CDS after failed ERCP in DMBO.
Right Atrial Intimal Sarcoma on 18F-FDG PET/CT
Authors: Nick Janssen, Jef Verheyen, Adrien Albert
Journal: Clinical Nuclear Medicine (2020)

Abstract A right atrial mass was discovered with transthoracic cardiac ultrasound in a complaint-free, 81-year-old man at his yearly cardiological checkup. Further investigation of the mass with transesophageal cardiac ultrasound showed a well-defined nodular mass of approximately 3 × 3 cm, in close proximity to the posterior wall of the right atrium. The patient underwent an 18 F-FDG PET/CT, which showed a right atrial mass with very high FDG uptake, suggesting a malignant process. The mass was surgically removed, and anatomopathological assessment revealed an intimal sarcoma, which is a very malignant tumor and an extremely rare occurrence at this location.
SPHINCTEROPLASTY, ELECTROHYDRAULIC LITHOTRIPSY AND FINAL PLACEMENT OF A SEMS INTO THE BILE DUCT OF A PATIENT WITH SURGICALLY ALTERED UPPER GI ANATOMY USING DOUBLE-BALLOON ENTEROSCOPY-ERCP
Authors: A Martínez-Alcalá García, PT Kroener, I Jovanovic, K Mönkemüller
Journal: Endoscopy (2020)

87-year-old multi-morbid female with complex choledocholithiasis had undergone several colonoscopy and DBE-assisted ERCPs in attempts to clear the bile duct, which was dilated, tortuous and distally stenotic, resulting in recurrent obstruction and cholangitis.
ACCURACY OF CAPSULE ENDOSCOPY IN THE DIAGNOSIS OF GASTROINTESTINAL GRAFT-VERSUS-HOST-DISEASE
Authors: GB Velasco, R Palos-Cuellar, MR Domínguez-García, OM Solórzano-Pineda, RA Zamarripa-Mottu, E Murcio-Pérez, JM Blancas-Valencia, OV Hernández-Mondragón
Journal: Endoscopy (2020)

Aims Graft-versus-host disease (GVHD) is a common complication of hematopoietic cell transplantation. It can involve the skin, lungs, liver and gastrointestinal (GI) tract. The small bowel is one of the principles targets in the GI tract. The capsule endoscopy (CE) is a safe procedure and can be a useful tool for a quicker diagnosis in GI GVHD. The aim of this study is to compare the accuracy of the CE in GVHD with the histopathological findings.
Cerebral Cavernous Malformations
Authors: Daniele Rigamonti, Mark N. Hadley, Burton P. Drayer, Peter C. Johnson, Karen Hoenig-Rigamonti, J. Thomas Knight, Robert F. Spetzler
Journal: New England Journal of Medicine (1988)

We studied 24 patients with histologically verified cerebral cavernous malformations, reviewing the familial occurrence and presenting signs, symptoms, and radiographic features of the disorder. Eleven patients had no evidence of a heritable trait and had negative family histories. Thirteen patients were members of six unrelated Mexican-American families. Sixty-four first-degree and second-degree relatives were examined, and family pedigrees were established. Most relatives (83 percent) were asymptomatic; 11 percent had seizures. Magnetic resonance imaging was performed in 16 relatives (5 of whom were asymptomatic). Fourteen of the 16 studies revealed cavernous malformations; 11 studies identified multiple lesions. As compared with computerized tomography and angiography, magnetic resonance imaging was far more accurate in detecting cavernous malformations. We conclude that cavernous malformations are more prevalent than previously reported, and that a familial form of the disorder exists that is more common than expected, with a high incidence of multiple lesions and an increased frequency of occurrence among Mexican-American families. Magnetic resonance imaging is the radiographic technique of choice for the identification and follow-up of these lesions. (N Engl J Med 1988; 319:343–7.)
Sputum Il-17a Levels Correlate With Biomarkers Of Non-Eosinophilic Inflammation In Patients With Asthma
Authors: G Hynes, S Go, S J Thulborn, C Borg, C Connolly, R Shrimanker, L Xue, M Bafadhel, I Pavord, U Oxford
Journal: American Journal of Respiratory and Critical Care Medicine (2017)
USE OF NARROW BAND IMAGING COLONOSCOPY IN DIAGNOSIS OF ULCERATIVE COLITIS, CORRELATION WITH CONVENTIONAL COLONOSCOPY &amp; HISTOPATHOLOGY
Authors: A Shamseya, E Aly, KA Abdelaaty, R Ezzat, M Fawzy
Journal: Endoscopy (2020)

Aims Ulcerative colitis is a disease of increasing incidence and may progress to colorectal cancer (CRC). Early detection of dysplastic changes is required. Narrow Band Imaging (NBI) is an imaging procedure that is supposed to increase the yielding of diagnosis of ulcerative colitis.
ESD CURRICULUM IN FRANCE: A COMPARATIVE STUDY OF LEARNING CURVES IN 3 FRENCH CENTERS WITH DIFFERENT TRAINING METHODS
Authors: M Schaefer, T Wallenhorst, R Legros, A Lamoureux, J Albouys, S Hahn, M Dahan, C Gouynou, H Lepetit, J-B Chevaux, J Jacques
Journal: Endoscopy (2020)

Aims Development of ESD in Europe remains limited compared to Japan. ESGE lately published a position statement for the training in ESD. We aimed to compare the learning curves of three french centers, with different curriculum.
Severe obesity, increasing age and male sex are independently associated with worse in-hospital outcomes, and higher in-hospital mortality, in a cohort of patients with COVID-19 in the Bronx, New York
Authors: Leonidas Palaiodimos, Damianos G. Kokkinidis, Weijia Li, Dimitrios Karamanis, Jennifer Ognibene, Shitij Arora, William N. Southern, Christos S. Mantzoros
Journal: Metabolism (2020)
THE USEFULNESS OF PROPHYLACTIC TEMPORARY 3F PANCREATIC DUCT STENT TO PREVENT POST-ERCP PANCREATITIS IN PATIENTS WITH BILLROTH II GASTRECTOMY
Authors: HH Jo, DH Kwun, JH Moon, YN Lee, JK Park, SJ Jo, MH Choi, TH Lee, SH Park, SW Cha, YD Cho
Journal: Endoscopy (2020)

Aims Biliary cannulation in patients with Billroth II gastrectomy is more difficult than normal anatomy. Difficult cannulation can lead to post-ERCP pancreatitis (PEP). Prophylactic pancreatic stent (PS) can reduce the frequency and severity of PEP. Especially, prophylactic temporary 3F PS placement is known to be effective to reduce PEP with spontaneous stent dislodgment. The aim of this study is to evaluate the effectiveness and spontaneous dislodgement rate of 3F PS in patients with Billroth II gastrectomy comparing with normal anatomy with a difficult biliary cannulation.
Erratum: Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection (Nature Immunology (2009) 10 (831-839))
Authors: A L Johnson, L Aravind, N Shulzhenko, A Morgun, S Y Choi, T L Crockford, T Lambe, H Domaschenz, E M Kucharska, L Zheng, C G Vinuesa, M J Lenardo, C C Goodnow, R J Cornall, R H Schwartz
Journal: Nature Immunology (2010)
The probiotic <i>L. casei</i> LC-XCAL™ improves metabolic health in a diet-induced obesity mouse model without altering the microbiome
Authors: Calum J. Walsh, Selena Healy, Paul W. O’Toole, Eileen F. Murphy, Paul D. Cotter
Journal: Gut Microbes (2020)

Chronic low-grade inflammation associated with obesity may be a target for improvement of metabolic health. Some exopolysaccharide (EPS)-producing bacteria have been shown to have anti-inflammatory effects in gastrointestinal inflammatory conditions. However, evidence for the role of EPS-producing probiotics in the management of obesity and associated conditions is scarce and the role of the microbiota is unclear. In this study, two probiotic candidates were screened for their effects on metabolic health using the diet-induced obesity (DIO) mouse model. Mice fed a high-fat diet supplemented with the anti-inflammatory, EPS-producing strain L. casei LC-XCAL™ showed significantly reduced hepatic triglycerides, hepatic total cholesterol, and fat pad weight compared to those fed a high-fat diet alone, likely as a result of reduced energy absorption from food. 16-S rRNA amplicon analysis of the fecal microbiota of these mice indicated that the altered metabolic phenotype as a result of the L. casei LC-XCAL strain administration was not associated with an overall change in the composition or inferred functional capacity of the fecal microbiota despite some abundance changes in individual taxa and functions. These findings provide evidence that specific microbial strategies can improve metabolic health independent of the microbiome and reinforce the importance of carefully selecting the most appropriate strain for specific indications by thorough screening programmes.
VIDEO CASE REPORT: ENDOSCOPIC RESLEEVE GASTROPLASTY (ERSG)
Authors: A D’Alessandro, FP Zito, L Bertolani, E Giglio, U Bardi, C Giardiello, G Galasso
Journal: Endoscopy (2020)

We present a case report of C.P. (F 41ys) with weight regain (25 Kg) after sleeve gastrectomy (BMI 40,1 Kg/m2). Procedure was performed in general anaesthesia using Apollo Overstitch Suturing Device. The suture pattern was circumferencial from the distal margin of the suture-line to 2 cm under the Z-line. We used 4 not-resorbable 2.0 sutures and the time of procedure was 55 minutes. The day after, radiological study showed a filiform passage of gastrografin with sub-cardial stagnation. In our series of 10 patients (BMI: 35±3.7 Kg/m2) we registered a significant reduction of BMI (31.2±2,4 Kg/m2) without adverse events.
COVID-19: implications for immunosuppression in kidney disease and transplantation
Authors: Andreas Kronbichler, Philipp Gauckler, Martin Windpessl, Jae Il Shin, Vivekanand Jha, Brad H. Rovin, Rainer Oberbauer
Journal: Nature Reviews Nephrology (2020)

The coronavirus disease 2019 (COVID-19) pandemic poses important challenges to the care of patients with immune-mediated kidney diseases and to kidney transplant recipients. Here, we discuss the management of immunosuppression for these patients during the pandemic and suggest potential approaches that could be considered in the absence of validated strategies.
Association of preceding psychosis risk states and non‐psychotic mental disorders with incidence of clinical psychosis in the general population: a prospective study in the NEMESIS‐2 cohort
Authors: Sinan Guloksuz, Lotta‐Katrin Pries, Margreet ten Have, Ron de Graaf, Saskia van Dorsselaer, Boris Klingenberg, Maarten Bak, Bochao D. Lin, Kristel R. van Eijk, Philippe Delespaul, Therese van Amelsvoort, Jurjen J. Luykx, Bart P.F. Rutten, Jim van Os
Journal: World Psychiatry (2020)

The validity and clinical utility of the concept of “clinical high risk” (CHR) for psychosis have so far been investigated only in risk‐enriched samples in clinical settings. In this population‐based prospective study, we aimed – for the first time – to assess the incidence rate of clinical psychosis and es­timate the population attributable fraction (PAF) of that incidence for preceding psychosis risk states and DSM‐IV diagnoses of non‐psychotic mental disorders (mood disorders, anxiety disorders, alcohol use disorders, and drug use disorders). All analyses were adjusted for age, gender and education. The incidence rate of clinical psychosis was 63.0 per 100,000 person‐years. The mutually‐adjusted Cox proportional hazards model indicated that preceding diagnoses of mood disorders (hazard ratio, HR=10.67, 95% CI: 3.12‐36.49), psychosis high‐risk state (HR=7.86, 95% CI: 2.76‐22.42) and drug use disorders (HR=5.33, 95% CI: 1.61‐17.64) were associated with an increased risk for clinical psychosis incidence. Of the clinical psychosis incidence in the population, 85.5% (95% CI: 64.6‐94.1) was attributable to prior psychopathology, with mood disorders (PAF=66.2, 95% CI: 33.4‐82.9), psychosis high‐risk state (PAF=36.9, 95% CI: 11.3‐55.1), and drug use disorders (PAF=18.7, 95% CI: –0.9 to 34.6) as the most important factors. Although the psychosis high‐risk state displayed a high relative risk for clinical psychosis outcome even after adjusting for other psychopathology, the PAF was comparatively low, given the low prevalence of psychosis high‐risk states in the population. These findings provide empirical evidence for the “prevention paradox” of targeted CHR early intervention. A comprehensive prevention strategy with a focus on broader psychopathology may be more effective than the current psychosis‐focused approach for achieving population‐based improvements in prevention of psychotic disorders.
POUCHOSCOPY AS A USEFUL TOOL FOR THE DIAGNOSIS AND TREATMENT OF PATIENTS WITH IPAA
Authors: T Emmanouil, S Gavriel, P Alepas, G Sourtse, IS Papanikolaou
Journal: Endoscopy (2020)

Aims Pouchoscopy is a useful tool for the study of patients operated with total colectomy and ileal pouch anal anastomosis (IPAA). It can be used either for the diagnosis of pouchitis in combination with clinical presentation and histology or for endoscopic interventions if post surgery complications appear.
Effects of yoga on depressive symptoms in people with mental disorders: a systematic review and meta-analysis
Authors: Jacinta Brinsley, Felipe Schuch, Oscar Lederman, Danielle Girard, Matthew Smout, Maarten A Immink, Brendon Stubbs, Joseph Firth, Kade Davison, Simon Rosenbaum
Journal: British Journal of Sports Medicine (2020)

Objective To assess whether physically active yoga is superior to waitlist control, treatment as usual and attention control in alleviating depressive symptoms in people with a diagnosed mental disorder recognised by the Diagnostic and Statistical Manual of Mental Disorders (DSM). Design Systematic review and meta-analysis following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Data sources Data were obtained from online databases (MEDLINE, EMBASE, PsychINFO, CENTRAL, EMCARE, PEDro). The search and collection of eligible studies was conducted up to 14 May 2019 (PROSPERO registration No CRD42018090441). Eligibility criteria for selecting studies We included randomised controlled trials with a yoga intervention comprising ≥50% physical activity in adults with a recognised diagnosed mental disorder according to DSM-3, 4 or 5. Results 19 studies were included in the review (1080 participants) and 13 studies were included in the meta-analysis (632 participants). Disorders of depression, post-traumatic stress, schizophrenia, anxiety, alcohol dependence and bipolar were included. Yoga showed greater reductions in depressive symptoms than waitlist, treatment as usual and attention control (standardised mean difference=0.41; 95% CI −0.65 to −0.17; p&lt;0.001). Greater reductions in depressive symptoms were associated with higher frequency of yoga sessions per week (β=−0.44, p&lt;0.01).