tbuckley/cabot-search huggingface dataset:
P2Y6 Signaling Controls an Innate Alveolar Macrophage-NK Cell Axis That Dampens Type 2 Lung Immunopathology
Authors: Jun Nagai, Barbara Balestrieri, Laura B. Fanning, Timothy Kyin, Haley Cirka, Junrui Lin, Patrick J. Brennan, Joshua A. Boyce
Journal: Journal of Allergy and Clinical Immunology (2019)
Abstract 20645: Ambient Circulation Surrounding an Ablation Catheter Tip Will Affect Delivery of Radiofrequency Current and Ablation Lesion Characteristics
Authors: Matthew M Zipse, Lijun Zheng, Ryan T Borne, Joseph L Schuller, Wendy S Tzou, William H Sauer, Duy T Nguyen
Journal: Circulation (2017)

Introduction: The circulating environment (CE) surrounding an ablation catheter electrode may affect radiofrequency (RF) current. A higher flow CE around a catheter tip may impact RF of targeted ca...
A Machine-Learning Sepsis Prediction Model for Patients Undergoing Hematopoietic Cell Transplantation
Authors: Sanjeet Dadwal, Zahra Eftekhari, Tushondra Thomas, Deron Johnson, Dongyun Yang, Sally Mokhtari, Liana Nikolaenko, Janet Munu, Ryotaro Nakamura
Journal: Blood (2018)
Efficacy and Safety of CPX-351 Versus 7+3 in Older Adults with Secondary Acute Myeloid Leukemia: Combined Subgroup Analysis of Phase 2 and Phase 3 Studies
Authors: Jeffrey E. Lancet, Ellen K Ritchie, Geoffrey L. Uy, Bruno C Medeiros, Laura F. Newell, Tara L. Lin, Donna Hogge, Robert K. Stuart, Stephen A Strickland, Scott R Solomon, Richard M. Stone, Jonathan E. Kolitz, Dale L. Bixby, Gary J. Schiller, Matthew J. Wieduwilt, Tibor Kovacsovics, Robert J. Ryan, Michael Chiarella, Arthur C Louie, Jorge E. Cortes
Journal: Blood (2017)
Being misunderstood in autism: The role of motor disruption in expressive communication, implications for satisfying social relations
Authors: Jonathan Delafield-Butt, Colwyn Trevarthen, Philip Rowe, Christopher Gillberg
Journal: Behavioral and Brain Sciences (2019)

Abstract Jaswal &amp; Akhtar's outstanding target article identifies the necessary social nature of the human mind, even in autism. We agree with the authors and present significant contributory origins of this autistic isolation in disruption of purposeful movement made social from infancy. Timing differences in expression can be misunderstood in embodied engagement, and social intention misread. Sensitive relations can repair this.
Fried food linked to increased risk of death among older US women
Authors: Zosia Kmietowicz
Journal: BMJ (2019)

Regularly eating fried food is linked with a heightened risk of death from any cause and of heart related death among postmenopausal women, a US study published in The BMJ has found.1

The researchers say that reducing consumption of fried foods, especially fried chicken and fried fish or shellfish, could have a positive public health impact.

Up to a third of North American adults have fast food every day, and previous studies have shown that a greater intake of fried food is associated with a higher risk of type 2 diabetes and heart disease. But evidence about the risk of death …
Investigation of the skin microbiome: swabs vs. biopsies
Authors: S. Prast‐Nielsen, A.‐M. Tobin, K. Adamzik, A. Powles, L.W. Hugerth, C. Sweeney, B. Kirby, L. Engstrand, L. Fry
Journal: British Journal of Dermatology (2019)

BackgroundHuman skin is populated by diverse bacteria and there is increasing evidence that resident bacteria play a key role initiating immune responses in cutaneous diseases such as atopic dermatitis, psoriasis and hidradenitis suppurativa. Bacteria are present at all layers of the skin but many studies have relied on swabs to profile the skin microbiota.
Efficacy and safety of dabrafenib (D) and trametinib (T) in patients (pts) with <i>BRAF</i> V600E–mutated biliary tract cancer (BTC): A cohort of the ROAR basket trial.
Authors: Zev A. Wainberg, Ulrik Niels Lassen, Elena Elez, Antoine Italiano, Giuseppe Curigliano, Filippo G. De Braud, Gerald Prager, Richard Greil, Alexander Stein, Angelica Fasolo, Jan H. M. Schellens, Patrick Y. Wen, Aislyn D. Boran, Paul Burgess, Eduard Gasal, Palanichamy Ilankumaran, Vivek Subbiah
Journal: Journal of Clinical Oncology (2019)

187 Background: BTCs are rare, aggressive malignancies with poor prognoses. Treatment options and outcomes after first-line therapy are not well defined. Median progression-free survival (PFS) in second-line BTC is &lt; 5 mo. Combined BRAF + MEK inhibition is efficacious in BRAF V600–mutated anaplastic thyroid cancer, melanoma, and lung cancer, but less so in BRAF V600E-mutated colorectal cancer. Activating BRAF V600E mutations have been reported in 0% to 20% of BTCs; thus, D (BRAF inhibitor) + T (MEK inhibitor) was evaluated as a treatment for pts with BRAF V600E–mutated BTC in the ROAR basket trial. Methods: In this phase II, open-label trial, pts with BRAF V600E mutations in 9 rare tumor types, including BTC, received D (150 mg BID) + T (2 mg QD) until unacceptable toxicity, disease progression, or death. Eligible pts had advanced or metastatic cancer and had been treated with ≥ 1 prior systemic therapy. The primary endpoint was investigator-assessed overall response rate (ORR). Secondary endpoints included duration of response (DOR), PFS, overall survival (OS), biomarker correlates, and safety. Results: Thirty-three pts with BTC had enrolled at data cutoff (January 3, 2018). BRAF V600E mutations were centrally confirmed in 30 of 33 pts with BTC (91%). Median age was 58 y, and 78% had received ≥ 2 prior lines of systemic therapy. 32 of 33 pts with BTC were evaluable. Investigator-assessed ORR was 41% (13/32; 95% CI, 24%-59%), with 6 of 13 responses ongoing at data cutoff, 7 of 13 pts (54%) had a DOR ≥ 6 mo. Median PFS was 7.2 mo (95% CI, 4.6-10.1 mo), and median OS was 11.3 mo (95% CI, 7.3-17.6 mo). Grade 3/4 adverse events in ≥ 3 pts were increased γ-glutamyltransferase (n = 3 [9%]) and decreased white blood cell count (n = 3 pts [9%]). Biomarker analyses demonstrate a heterogeneous genetic landscape, and suggest a higher baseline expression of MAPK pathway genes in the pts who did not respond to D + T. Conclusions: D + T demonstrated promising efficacy in pts with BTC, with a favorable safety profile. These pts should be considered for BRAF mutation analysis, and D + T should be considered for pts with BRAF V600E-mutated BTC. Clinical trial information: NCT02034110.
<i>Notes from the Field:</i> Assessment of State-Level Influenza Season Severity — Minnesota and Utah, 2017–18 Influenza Season
Authors: Michelle M. Hughes, Joshua D. Doyle, Keegan McCaffrey, Melissa McMahon, Melanie Spencer, Karen Martin, Gregg M. Reed, Anna E. Carmack, Shikha Garg, Melissa Rolfes, Carrie Reed, Matthew Biggerstaff
Journal: MMWR Morbidity and Mortality Weekly Report (2019)

The U.S. 2017â18 influenza season was a high-severity season, with the highest number of outpatient visits for influenza-like illness since the 2009â10 pandemic and the highest rate of influenza-associated hospitalizations since the system expanded to include adult hospitalizations during the 2005â06 season.
Mechanism of Abnormal Septal Motion in Left Bundle Branch Block
Authors: John M. Aalen, Espen W. Remme, Camilla K. Larsen, Oyvind S. Andersen, Magnus Krogh, Jürgen Duchenne, Einar Hopp, Stian Ross, Ahmed S. Beela, Erik Kongsgaard, Jacob Bergsland, Hans H. Odland, Helge Skulstad, Anders Opdahl, Jens-Uwe Voigt, Otto A. Smiseth
Journal: JACC. Cardiovascular imaging (2019)
Abstract 20522: Sglt2 Inhibition With Dapagliflozin Improves Coronary Vascular Derangement in the Leptin-Deficient Ob/ob Mice
Authors: Damilola Adingupu, Linda Hägerstrand, Malin Palmér, Anastassia Karageorgis, Mickaël El Hachmane, Sven Göpel, Li-Ming Gan, Ann-Cathrine Jönsson-Rylander
Journal: Circulation (2017)

Introduction: In diabetic patients with cardiovascular (CV) comorbidities, treatment with SGLT2 inhibitors have been shown to improve CV outcome. However, effects of SGLT2 inhibition on cardiovascu...
Validation of POD24 As a Robust Early Clinical Endpoint of Poor Survival in Follicular Lymphoma: Results from the Follicular Lymphoma Analysis of Surrogacy Hypothesis (FLASH) Investigation Using Individual Data from 5,453 Patients on 13 Clinical Trials
Authors: Carla Casulo, Jennifer Le-Rademacher, Jesse Dixon, Gilles Salles, Eva Hoster, Michael Herold, Wolfgang Hiddemann, Catherine Sebban, Robert Marcus, Eva Kimby, Howard Hochster, Umberto Vitolo, Emmanuel Gyan, Fang-Shu Ou, Tina Nielsen, Kenneth A. Foon, Shi Qiuan, Christopher Flowers
Journal: Blood (2017)
Abstract P4-09-07: Higher risk of metachronous contralateral breast cancer in patients with invasive lobular breast cancer
Authors: D Akdeniz, I Kramer, CH van Deurzen, M Schaapveld, PJ Westenend, AC Voogd, A Jager, EW Steyerberg, S Sleijfer, MK Schmidt, MJ Hooning
Journal: Cancer Research (2019)

Abstract Background: Risk of metachronous contralateral breast cancer (CBC) is an important health issue in primary breast cancer (PBC) survivors. Individualized CBC risk prediction can help identify patients at high or low risk who may or may not benefit from additional surveillance and treatment. For lobular PBC, inconsistent results have been reported on an association with increased risk of CBC. We investigated CBC risk in lobular versus ductal PBC using a large nationwide dataset and taking into account age at PBC and (neo-)adjuvant systemic therapy effects. Patients and Methods: We selected women diagnosed between 2003 and 2010 with early invasive lobular, lobular mixed with other types, or ductal PBC from the Netherlands Cancer Registry. Categorical and continuous characteristics between the 3 groups were compared using the chi-square statistics and the Kruskal-Wallis test, respectively. Competing risk analyses were applied to determine CBC incidence. Multivariable subdistribution hazard ratios (SHRs) were adjusted for primary tumor stage, age at PBC diagnosis, radiotherapy, (neo-)adjuvant chemotherapy and endocrine therapy. Results: We selected 74,373 women aged &amp;gt;18 years with lobular (n=8,903), lobular mixed (n=3,512), and ductal (n=62,230) PBC. Women with lobular PBC were older at diagnosis than women with lobular mixed or ductal PBC (61 vs. 58 vs. 58 years, respectively), more often had ER-positive PBC (95.7% vs. 94.1% vs. 79.6%) and were more often systemically treated with only endocrine therapy (30.7% vs. 24.9% vs. 19.7%), while less often treated with only chemotherapy (4.2% vs. 5.3% vs. 15.4%). Ten-year cumulative CBC incidences in women with lobular, lobular mixed or ductal PBC were 3.2%, 3.6% and 2.8% when treated with systemic therapy (chemotherapy and/or endocrine therapy) and 6.6%, 7.7% and 5.6% without systemic therapy, respectively. Multivariable SHRs were 1.19 (95% CI: 1.05-1.34) for lobular and 1.39 (95% CI: 1.17-1.65) for lobular mixed versus ductal PBC; for women &amp;lt;50 years, risk differences were larger: 1.60 (95% CI: 1.26-2.05) and 1.43 (95% CI: 1.00-2.06), respectively. Conclusion: Lobular histology and lobular mixed histology are independent risk factors for CBC development, and should be considered as prognostic factors when refining CBC risk prediction models. Citation Format: Akdeniz D, Kramer I, van Deurzen CH, Schaapveld M, Westenend PJ, Voogd AC, Jager A, Steyerberg EW, Sleijfer S, Schmidt MK, Hooning MJ. Higher risk of metachronous contralateral breast cancer in patients with invasive lobular breast cancer [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr P4-09-07.
Vaccination: “fake news” on social media may be harming UK uptake, report warns
Authors: Gareth Iacobucci
Journal: BMJ (2019)

The spread of misinformation and “fake news” on social media may be fuelling public concern about potential side effects of vaccination and could restrict uptake, the Royal Society for Public Health has warned.1

Although the UK maintains “world leading” levels of vaccine coverage, the extent to which social media propagates misinformation about vaccinations is a concern, it said.

The society conducted a literature review of relevant articles and three public surveys carried out in May 2018.1 These included a poll of 2622 UK parents, which found that two in five (41%; 1075) had been exposed to negative messages about vaccines on social media. …
Abstract 19902: Impact of Cardiac Rehabilitation on Total Mortality After Myectomy Procedure for Hypertrophic Cardiomyopathy
Authors: Umama Gorsi, Jose R Medina-Inojosa, Ray W Squires
Journal: Circulation (2017)

Introduction: Cardiac rehabilitation (CR) is proven to be beneficial for patients with cardiovascular diseases CVD in reducing mortality. The clinical impact of CR in post myectomy patients is unkn...
Abstract 010: Prevention of Chronic Kidney Disease: Impact of Addressing the Blood Pressure Distribution, Not Just the Tail
Authors: Shakia T Hardy, Christy L Avery, Donglin Zeng, Abhijit V Kshirsagar, Anthony J Viera, Gerardo Heiss
Journal: Circulation (2018)

Background: While much of the chronic kidney disease (CKD) literature focuses on the role of blood pressure reduction in delaying CKD progression, little is known about the benefits of modest population-wide decrements in blood pressure on incident CKD. Methods: We used multivariable linear regression to estimate incidence rate differences comparing the impact of 2 pragmatic hypothetical interventions to reduce the incidence of CKD: (1) a population-wide intervention that reduced systolic blood pressure by 1 mmHg and (2) targeted interventions that reduced the prevalence of unaware, untreated, or uncontrolled blood pressure above goal (as defined by Joint National Committee (JNC) 7 and JNC 8 thresholds) by 10%. The population comprised 15,390 participants of the Atherosclerosis Risk in Communities Study (45-64 years of age at baseline, 1987-1989). Incident CKD was ascertained from laboratory assays and abstraction of medical records. Results: Over a mean of 20 years of follow up, 3,852 incident CKD events were ascertained. After adjustment for antihypertensive use, gender, diabetes, and age a 1 mmHg decrement in SBP across the total population was associated with an estimated 11.7 and 13.4 fewer incident CKD events per 100,000 person-years (PY) in African Americans and white Americans, respectively. Among participants with blood pressure above JNC 7 goal, a 10% decrease in unaware, untreated, or uncontrolled blood pressure was associated with 3.2, 2.8 and 5.8 fewer incident CKD events per 100,000 PY in African Americans and 3.1, 0.7, and 1.0 fewer incident CKD per 100,000 PY in white Americans. Interventions targeted to the population with blood pressure above JNC 7 goal produced greater reductions in incident CKD than interventions targeted at reductions in blood pressure above JNC 8 treatment goal. Extrapolation to the US African American and white American populations age greater than 45 years (NHANES 2010) suggests that a 1 mmHg decrement in SBP could result in approximately 9,996 fewer incident CKD events annually compared to approximately 2,098, 636, and 1,598 fewer incident CKD events potentially preventable from 10% decreases in unaware, untreated, and uncontrolled blood pressure above goal. Conclusions: Modest blood pressure interventions population-wide provide an opportunity to substantially reduce the burden of incident CKD. Among the high-risk population, lowering the threshold for blood pressure treatment to JNC 7’s treatment goal could increase the impact of high-risk strategies on CKD prevention when compared to JNC 8’s treatment goal.
Gene editing of the multi-copy H2A.B gene and its importance for fertility
Authors: Nur Diana Anuar, Sebastian Kurscheid, Matt Field, Lei Zhang, Edward Rebar, Philip Gregory, Thierry Buchou, Josephine Bowles, Peter Koopman, David J. Tremethick, Tatiana A. Soboleva
Journal: Genome biology (2019)

Altering the biochemical makeup of chromatin by the incorporation of histone variants during development represents a key mechanism in regulating gene expression. The histone variant H2A.B, H2A.B.3 in mice, appeared late in evolution and is most highly expressed in the testis. In the mouse, it is encoded by three different genes. H2A.B expression is spatially and temporally regulated during spermatogenesis being most highly expressed in the haploid round spermatid stage. Active genes gain H2A.B where it directly interacts with polymerase II and RNA processing factors within splicing speckles. However, the importance of H2A.B for gene expression and fertility are unknown. Here, we report the first mouse knockout of this histone variant and its effects on fertility, nuclear organization, and gene expression. In view of the controversy related to the generation of off-target mutations by gene editing approaches, we test the specificity of TALENs by disrupting the H2A.B multi-copy gene family using only one pair of TALENs. We show that TALENs do display a high level of specificity since no off-target mutations are detected by bioinformatics analyses of exome sequences obtained from three consecutive generations of knockout mice and by Sanger DNA sequencing. Male H2A.B.3 knockout mice are subfertile and display an increase in the proportion of abnormal sperm and clogged seminiferous tubules. Significantly, a loss of proper RNA Pol II targeting to distinct transcription–splicing territories and changes to pre-mRNA splicing are observed. We have produced the first H2A.B knockout mouse using the TALEN approach.
Abstract 15645: Plasma Trans-fatty Acids and Lipid and Lipoprotein Concentrations Among U.S. Adults: Findings From NHANES 1999-2000 and 2009-2010
Authors: Quanhe Yang, Zefeng Zhang, Fleetwood Loustalot, Hubert Vesper, Samuel P Caudil, Mattew Ritchey, Cathleen Gillespie, Robert Merritt, Yuling Hong, Barbara B Bowman
Journal: Circulation (2016)

Introduction: High intake of trans-fatty acids (TFAs), especially industrially-produced TFA, can lead to unfavorable lipid and lipoprotein concentrations and increased risk for cardiovascular disea...
A novel device for the endoscopic management of buried bumper syndrome
Authors: Pieter Hindryckx, Barbara Dhooghe, Andreas Wannhoff
Journal: Endoscopy (2019)

Abstract Background Buried bumper syndrome (BBS) is a complication of percutaneous endoscopic gastrostomy (PEG) in which the internal bumper is overgrown by the gastric mucosa. Apart from loss of patency of the PEG tube, the buried bumper may evoke symptoms such as abdominal pain or peritubular leakage. While the management of an incompletely buried bumper is fairly straightforward, this is not the case for a completely buried bumper. Different approaches to remove completely buried bumpers have been described, including endoscopic knife- or papillotome-based techniques. However, these devices are used off-label and the procedures can be laborious. Methods The Flamingo device has recently been introduced as the first tool specifically designed to remove a completely buried bumper. Results We describe the technique and our first experience in five patients with a completely (n = 4) or almost completely (n = 1) buried bumper. Fast and save removal of the buried bumper was obtained in all patients. Conclusion We believe that this device has the potential to become the standard first-line tool for the management of completely buried bumpers.
Abstract 18517: Treprostinil Decreases Platelet Microparticles in Pediatric Pulmonary Hypertension
Authors: Nour Bacha, Marilyne Levy, Coralie L Guerin, Bernard le Bonniec, Annie Harroche, Pascale Gaussem, Dominique Israel-Biet, Chantal M Boulanger, David M Smadja
Journal: Circulation (2017)

Introduction: Vasodilator therapy has greatly improved Pulmonary arterial hypertension (PAH) prognosis. Increased numbers of circulating microparticles (MPs) are found in adult PAH patients and might correlate with disease severity. Therefore, our purpose was to determine if MPs are upregulated in pediatric PAH, and the impact of vasodilator therapies on MPs count and function. Methods: Population study consisted of 27 patients with Congenital Heart Disease (CHD) and elevated pulmonary vascular resistance (CHD-PAH) or idiopathic PAH (iPAH) with a median age of 6.09 years. Among the 27 patients, 12 of them never received any therapy, 8 received one or two oral vasodilators (bosentan and/or sildenafil) and 6 received a triple therapy associating bosentan, sildenafil and SC-treprostinil. Results: Compared to healthy controls, all circulating MP subpopulations were found higher in untreated PAH patients confirming results of adult PAH patients. No significant differences were found between untreated patients ...
Achieving Clinical Remission for Patients With Rheumatoid Arthritis
Authors: Daniel Aletaha, Josef S. Smolen
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MicroRNA-23a-3p Inhibits Mucosal Melanoma Growth and Progression through Targeting Adenylate Cyclase 1 and Attenuating cAMP and MAPK Pathways
Authors: Meng Ma, Jie Dai, Huan Tang, Tianxiao Xu, Sifan Yu, Lu Si, Chuanliang Cui, Xinan Sheng, Zhihong Chi, Lili Mao, Xiaowen Wu, Lu Yang, Huan Yu, Siming Li, Bin Lian, Bixiang Tang, Xuan Wang, Xieqiao Yan, Xue Bai, Li Zhou, Yan Kong, Jun Guo
Journal: Theranostics (2019)

Mucosal melanoma (MM) is the second most common melanoma subtype in Asian populations. Deregulation of microRNAs (miRNAs) has been extensively investigated in various cancers, including cutaneous melanoma. However, the roles of miRNAs in MM are unclear. In this study, we carried out miRNA profiling in MM, and we investigated the clinical and biological roles of miR-23a-3p in MM. Methods: miRNA expression in MM was profiled by miRNA microarray analysis. The expression of miR-23a-3p was quantitated by qRT-PCR in a cohort of 117 patients with MM, and its prognostic significance was evaluated. The biological effect of miR-23a-3p was demonstrated by both in vitro and in vivo studies through ectopic expression of miR-23a-3p. The target gene of miR-23a-3p and molecular pathway influenced by it was characterized using in silico target prediction tools, dual luciferase reporter assays, knockdown, and rescue experiments. Results: Microarray and qRT-PCR results showed that the miR-23a-3p level was substantially lower in MM, and low miR-23a-3p expression was significantly associated with poor outcomes. Ectopic expression of miR-23a-3p suppressed MM cell proliferation, migration, invasion, and tumorigenicity, indicating that miR-23a-3p has a tumor-suppressive role in MM. Mechanistic investigations identified adenylate cyclase 1 (ADCY1) as a direct target of miR-23a-3p in MM, and knockdown of ADCY1 recapitulated all the phenotypic characteristics of miR-23a-3p overexpression. Targeting of ADCY1 by miR-23a-3p resulted in the suppression of cyclic adenosine monophosphate (cAMP) and mitogen-activated protein kinase (MAPK) signaling pathways. Conclusions: Our data highlight the molecular etiology and clinical significance of miR-23a-3p in MM and reveal its major target and biological function. miR-23a-3p may represent a new prognostic biomarker or therapeutic target in MM.