tbuckley/cabot-search huggingface dataset:
IS THERE A CORRELATION BETWEEN THE ENDOSCOPIC APPEARANCE AND THE HISTOLOGICAL FINDINGS DURING ADULT CELIAC DISEASE?
Authors: S Zertiti, I Benelbarhdadi, FZ Chabib, C Berhili, N Lagdali, M Borahma, FZ Ajana
Journal: Endoscopy (2020)

Aims Celiac disease is an intolerance to gluten characterized histologically by villous atrophy that can be seen in the bulb and duodenum.Nevertheless an endoscopically healthy duodenum does not eliminate the disease, hence the interest of our study which is to study the correlation between the endoscopic abnormalities and the severity of villous atrophy.
TIME TRENDS IN ACUTE UPPER GASTROINTESTINAL BLEEDING: IS SOMETHING CHANGED IN PAST 10 YEARS?
Authors: V Milivojevic, I Rankovic, D Popovic, T Glisic, O Matejic, D Tomic, B Milicic, I Jovanovic, M Krstic, T Milosavljevic
Journal: Endoscopy (2020)

Aims To evaluate changes in clinico-epidemiologic characteristics of patients who presented with acute upper gastrointestal bleeding (AUGIB) during the last 10 years in Serbia
INCARCERATION OF THE COLONOSCOPE AND SIGMOID COLON IN AN INGUINAL HERNIA
Authors: OVH Mondragon, OM Solorzano Pineda, LF Garcia Contreras, EL de los Reyes
Journal: Endoscopy (2020)

A case of colonoscope incarceration in an inguinal hernia is presented as an uncommon complication during colonoscopy.
SMALL BOWEL CAPSULE ENDOSCOPY IN THE WEST OF IRELAND: A CLOSER LOOK AT THE FIRST YEAR
Authors: H O’Donovan, H Yousuf, D Gallagher, C Goulding
Journal: Endoscopy (2020)

Aims The European Society of Gastrointestinal Endoscopy (ESGE) recommends SBCE as the first line investigation in patients with obscure GI bleeding. SBCE is also indicated to assist in the diagnosis of small bowel Crohn’s disease. The aim of this study was to look at SBCE in the West of Ireland.
Genetics and Arrhythmias
Authors: Robert Roberts, Ramon Brugada
Journal: Annual Review of Medicine (2003)

The availability of chromosomal markers that span the human genome and improved high-throughput technology for genotyping and sequencing have led to major advances against genetic diseases. Genes have been identified for several disorders responsible for arrhythmias and sudden death. These genes all encode ion channels and are referred to as channelopathy genes. Congenital long QT syndrome is caused by mutations in genes encoding sodium or potassium channels. Brugada syndrome, only recently described, is due to mutations in a sodium channel and is an important cause of sudden death, particularly in Southeast Asia. Familial polymorphic ventricular tachycardia is due to a defect in the ryanodine receptor. A locus mapped to 10q32 is responsible for familial atrial fibrillation. Treatments based on knowledge of the molecular defect are being implemented for long QT syndrome and will probably provide paradigms for targeted treatment of acquired arrhythmias.
Effect of history of tuberculosis on specificity of Xpert MTB/RIF
Authors: Frederick Haraka, Samuel G. Schumacher, Amanda Ross, Anna Mantsoki, Sebastien Gagneux, Klaus Reither, Claudia M. Denkinger
Journal: European Respiratory Journal (2020)

<b>Specificity of Xpert MTB/RIF was lower in those with tuberculosis (TB) history compared to those without TB history and specificity increased as time since previous TB increased</b>https://bit.ly/2W4hWfX
No alteration of Cyp3A4 activity after major hepatectomy in the early postoperative period – A prospective before-after study
Authors: J. Jedamzik, J. Mühlbacher, F. Fitschek, C. Schwarz, J. Burhenne, U. Asenbaum, K. Kaczirek, G. Mikus
Journal: International Journal of Surgery (2020)
Effectiveness of seven-valent pneumococcal conjugate vaccine against invasive pneumococcal disease: a matched case-control study
Authors: Cynthia G. Whitney, Tamar Pilishvili, Monica M. Farley, William Schaffner, Allen S. Craig, Ruth Lynfield, Ann Christine Nyquist, Kenneth A. Gershman, Marietta Vazquez, Nancy M. Bennett, Arthur Reingold, Ann Thomas, Mary P. Glode, Elizabeth R. Zell, James H. Jorgensen, Bernard Beall, Anne Schuchat
Journal: The Lancet (2006)
Empagliflozin in Heart Failure
Authors: Matthew Griffin, Veena S. Rao, Juan Ivey-Miranda, James Fleming, Devin Mahoney, Christopher Maulion, Nisha Suda, Krishmita Siwakoti, Tariq Ahmad, Daniel Jacoby, Ralph Riello, Lavanya Bellumkonda, Zachary Cox, Sean Collins, Sangchoon Jeon, Jeffrey M. Turner, F. Perry Wilson, Javed Butler, Silvio E. Inzucchi, Jeffrey M. Testani
Journal: Circulation (2020)

Sodium-glucose cotransporter-2 inhibitors improve heart failure-related outcomes. The mechanisms underlying these benefits are not well understood, but diuretic properties may contribute. Traditional diuretics such as furosemide induce substantial neurohormonal activation, contributing to the limited improvement in intravascular volume often seen with these agents. However, the proximal tubular site of action of the sodium-glucose cotransporter-2 inhibitors may help circumvent these limitations.
TIMING OF PANCREATODUODENECTOMY AFTER BILIARY DRAINAGE IN PATIENTS WITH PERIAMPULLARY CANCER IN THE NETHERLANDS
Authors: NCM van Huijgevoort, AEJ Latenstein, TM Mackay, BA Bonsing, HC van Santvoort, MJ Bruno, RC Verdonk, JE van Hooft, MG Besselink
Journal: Endoscopy (2020)

Aims Obstructive jaundice is a frequent symptom in patients with periampullary cancer. Preoperative biliary drainage (PBD) is indicated in patients with cholangitis, severe jaundice, neoadjuvant chemotherapy and extended waiting time for definitive surgical treatment. Several studies suggest to delay surgery until 4-8 weeks after PBD to allow for recovery of the liver and immune function but consensus is lacking. The aim of this study is to investigate the relation between time from PBD to pancreatoduodenectomy and (major) postoperative outcomes in patients with periampullary cancer.
No detectable remodelling in adult human menisci: an analysis based on the C<sup>14</sup>bomb pulse
Authors: Christoffer Våben, Katja M Heinemeier, Peter Schjerling, Jesper Olsen, Michael Mørk Petersen, Michael Kjaer, Michael R Krogsgaard
Journal: British Journal of Sports Medicine (2020)

Objectives Bone and other human tissues remodel through life, for example, as a response to increasing load, and this prevents permanent destruction of the tissue. Non-traumatic meniscal rupture is a common musculoskeletal disease, but it is unknown if it is caused by inability of the menisci to remodel. The aim of this study was to determine whether meniscal collagen is remodelling throughout life. Methods The life-long turnover of the human meniscal collagens was explored by the 14 C bomb pulse method. 14 C levels were determined in menisci from 18 patients with osteoarthritis and 7 patients with healthy knees. Results There was a negligible turnover of the meniscal collagen in adults. This low turnover was observed in menisci from patients with knee osteoarthritis and in healthy menisci. Conclusion This study provides evidence that essentially no remodelling occurs in the adult human meniscal collagen structure and explains the clinical degeneration that is often seen in menisci of middle-aged and elderly persons. It suggests that strengthening of the collagen structure of menisci, as response to physical activity, may occur during childhood, while it is not possible in the adult population.
HIGH CLEANSING EFFICACY WITH OVERNIGHT SPLIT DOSING 1L NER1006 ACROSS SCREENING, DIAGNOSTIC AND SURVEILLANCE COLONOSCOPY: POST HOC ANALYSIS OF TWO RANDOMISED PHASE 3 CLINICAL TRIALS
Authors: MA Alvarez-Gonzalez, B Amlani, R Bisschops
Journal: Endoscopy (2020)

Aims We compared, per reason for colonoscopy (screening, surveillance or diagnostic), the cleansing performance of 1L polyethylene glycol NER1006 (PLENVU) versus two preparations.
Validation of diffusion MRI phenotypes for predicting response to bevacizumab in recurrent glioblastoma: post-hoc analysis of the EORTC-26101 trial
Authors: Marianne Schell, Irada Pflüger, Gianluca Brugnara, Fabian Isensee, Ulf Neuberger, Martha Foltyn, Tobias Kessler, Felix Sahm, Antje Wick, Martha Nowosielski, Sabine Heiland, Michael Weller, Michael Platten, Klaus H Maier-Hein, Andreas Von Deimling, Martin J Van Den Bent, Thierry Gorlia, Wolfgang Wick, Martin Bendszus, Philipp Kickingereder
Journal: Neuro-Oncology (2020)

This study validated a previously described diffusion MRI phenotype as a potential predictive imaging biomarker in patients with recurrent glioblastoma receiving bevacizumab (BEV).
CONCOMITANT MALIGNANT DUODENAL AND BILIARY STENOSIS: DUODENAL STENTING AND HEPATICOGASTROSTOMY DURING THE SAME PROCEDURE IS A SAFETY PROCEDURE (SAMETIME STUDY)
Authors: A Debourdeau, F Caillol, JP Ratone, J Winkler, C Decoster, C Pesenti, E Bories, M Giovannini
Journal: Endoscopy (2020)

Aims The concomitant biliary and duodenal malignant stenosis is a rare event, reflecting a locally advanced neoplastic process. We conducted a retrospective study to evaluate biliary drainage in association with duodenal stenting.
Transmission of SARS-CoV-2 in Domestic Cats
Authors: Peter J Halfmann, Masato Hatta, Shiho Chiba, Tadashi Maemura, Shufang Fan, Makoto Takeda, Noriko Kinoshita, Shin-Ichiro Hattori, Yuko Sakai-Tagawa, Kiyoko Iwatsuki-Horimoto, Masaki Imai, Yoshihiro Kawaoka
Journal: New England Journal of Medicine (2020)

Coronavirus in Cats SARS-CoV-2 was detected in three cats after they were cohoused with cats that had been experimentally inoculated with the virus. Cats may be a silent intermediate host of SARS-C...
A SINGLE CENTRE EXPERIENCE OF ESD AND EFTR OF 133 CASES IN INDIA WITHOUT USING RETRACTION DEVICES
Authors: P Desai, M Kabrawala, C Patel, R Prajapati, P Kalra, N Patel
Journal: Endoscopy (2020)

Aims Feasibility and outcome of endoscopic submucosal dissection for early submucosal and subepithelial lesion of gastrointestinal tract in western India- a single center experience without using any traction method.
ACUTE LOWER GASTROINTESTINAL BLEEDING: WHICH IS THE BETTER SCORE FOR EACH OUTCOME?
Authors: C Sequeira, IC Santos, M Coelho, E Dantas, C Teixeira, J Mangualde, AP Oliveira
Journal: Endoscopy (2020)

Aims: Introduction Although several scores have been proposed as risk stratification tools for acute lower gastrointestinal bleeding (ALGIB) there are few comparative studies among them.
EUS-GUIDED PERCUTANEOUS ENDOSCOPIC GASTROSTOMY (PEG)
Authors: S Baile-Maxía, L Medina, C Mangas-Sanjuan, M Bozhychko, F Ruiz, L Compañy, J Martínez, JA Casellas, JR Aparicio
Journal: Endoscopy (2020)

We present an alternative EUS-guided PEG technique in 2 patients deemed unfit for conventional PEG due to absence of transillumination or previous gastric surgery. An EUS target was created by filling a sterile glove with saline and placing it in the abdominal wall of the patient. EUS was performed and target identified from the stomach. Abdominal wall was punctured from the stomach with a 19 G needle and a 0.025ʹ’ guidewire was advanced. The guidewire was knotted to a string, which was passed into the stomach and drawn back through the mouth. The procedure was continued following the traditional technique.
EFFECT OF SUBMUCOSAL INJECTION IN ENDOSCOPIC PAPILLECTOMY OF AMPULLARY TUMOR: PROPENSITY-SCORE MATCHING ANALYSIS
Authors: JK Ryu, KH Chung, SH Lee, YT Kim, DH Lee
Journal: Endoscopy (2019)

All patients who underwent initial curative EP at our institution between March 2006 and March 2014 were retrospectively recruited. The presence of residual tumor after three months, recurrence-free survival and post-procedural adverse events were compared between the SI group and non-injection (NI) group. Propensity-score matching was performed between the two groups to reduce potential selection bias and confounding.
Estrogen Replacement Therapy and Risk of Ovarian Cancer in Postmenopausal Women
Authors: Lucy Gilbert, Srinivasan Krishnamurthy, Seang Lin Tan, Eduardo L. Franco
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Effect of Oral Corticosteroids on Circulating Type-2 Cytokine Producing Cells in Patients with Severe Eosinophilic Asthma
Authors: G Hynes, S Go, J Luo, R Shrimanker, C Borg, C Connolly, L Xue, I D Pavord
Journal: American Journal of Respiratory and Critical Care Medicine (2018)
Ferumoxytol MR Angiography
Authors: Sokratis Stoumpos, Pauline Hall Barrientos, Douglas H. Black, Karen Stevenson, Martin Hennessy, Alex T. Vesey, William Strauss, Ram Kasthuri, Aleksandra Radjenovic, David B. Kingsmore, Giles Roditi, Patrick B. Mark
Journal: JACC. Cardiovascular imaging (2020)
HYPERTENSIVE GASTROPATHY IN CIRRHOTIC PATIENTS: PREVALENCE AND PROGNOSTIC IMPACT
Authors: S Bradai, I Akkari, S Mrabet, EB Jazia
Journal: Endoscopy (2020)

Aims Esophageal (OV) and gastric (GV) varices are the most described endoscopic signs of portal hypertension (PHT) in cirrhotic patients. However, hypertensive gastropathy (HTG) is a cause of digestive hemorrhage by PHT often neglected and poorly studied.
Inhibition of xanthine oxidase in the acute phase of myocardial infarction prevents skeletal muscle abnormalities and exercise intolerance
Authors: Hideo Nambu, Shingo Takada, Satoshi Maekawa, Junichi Matsumoto, Naoya Kakutani, Takaaki Furihata, Ryosuke Shirakawa, Takashi Katayama, Takayuki Nakajima, Katsuma Yamanashi, Yoshikuni Obata, Ippei Nakano, Masaya Tsuda, Akimichi Saito, Arata Fukushima, Takashi Yokota, Junko Nio-Kobayashi, Hironobu Yasui, Kei Higashikawa, Yuji Kuge, Toshihisa Anzai, Hisataka Sabe, Shintaro Kinugawa
Journal: Cardiovascular Research (2020)

Exercise intolerance in patients with heart failure (HF) is partly attributed to skeletal muscle abnormalities. We have shown that reactive oxygen species (ROS) play a crucial role in skeletal muscle abnormalities, but the pathogenic mechanism remains unclear. Xanthine oxidase (XO) is reported to be an important mediator of ROS overproduction in ischaemic tissue. Here, we tested the hypothesis that skeletal muscle abnormalities in HF are initially caused by XO-derived ROS and are prevented by the inhibition of their production.
Cytogenetic changes in follicular lymphoma with a diffuse large cell component
Authors: Bhavana J. Dave, Dennis D. Weisenburger, Wing C. Chan, Smrati Jain, Michelle M. Hess, Warren G. Sanger
Journal: Cancer Research (2005)

4874  Follicular lymphoma (FL), one of the most common types of non-Hodgkin lymphoma (NHL), is typically an indolent NHL with a propensity to progress and transform into diffuse large B-cell lymphoma (DLBCL). Transformed NHL has an aggressive clinical course and is frequently refractory to therapy. Some cases of the FL contain a DLBCL component at presentation. In order to categorize specific cytogenetic changes that presumably play a role in progression/transformation and to identify cytogenetic differences, if any, from ‘pure’ FL cases, we examined the karyotypes of 30 consecutive, histologically-confirmed FL cases that had a high-grade follicular large cell component as well as DLBCL component; these represent cases undergoing transformation/progression at the time of diagnosis. Nearly all of the 30 cases were characterized by an extremely complex karyotype. We performed multicolor FISH (M-FISH) studies in available cryopreserved specimens to more completely define the karyotypes. Fifty percent of the cases (15/30) had a modal number of greater than 55 chromosomes and more than 35% of cases (11/30) did not have the t(14;18) which is characteristic of FL. Of these 11 cases without the t(14;18), three had either the t(3;14) or the variant t(3;22). The most common numerical abnormalities included gains of chromosomes X, 5, 7, 12 and 18, as well as losses of chromosomes 4, 9, and 13. Recurrent breakpoints observed in more than 20% of the cases included 1p36, 3q27, 4q35, 6q21-q23, 13q14, 14q32, and 18q21. Rearrangements in ≥3 cases included 4q31, 5q31, 6q15, 7q22, 9p13, 10q22, 10q24, 12p13, and 22q11.2. As determined by cytogenetic and M-FISH studies, some of these recurrent breakpoints represent early secondary karyotypic alterations among FL undergoing progression/transformation. Morphologic and cytogenetic correlation at diagnosis is important in delineating the genetic and molecular basis of progression/transformation in FL.
YAP-Mediated Recruitment of YY1 and EZH2 Represses Transcription of Key Cell-Cycle Regulators
Authors: Sany Hoxha, Alyssa Shepard, Scott Troutman, Huitian Diao, Joanne R. Doherty, Michalina Janiszewska, Robert M. Witwicki, Matthew E. Pipkin, William W. Ja, Michael S. Kareta, Joseph L. Kissil
Journal: Cancer Research (2020)

Abstract The Hippo pathway regulates cell proliferation and organ size through control of the transcriptional regulators YAP (yes-associated protein) and TAZ. Upon extracellular stimuli such as cell–cell contact, the pathway negatively regulates YAP through cytoplasmic sequestration. Under conditions of low cell density, YAP is nuclear and associates with enhancer regions and gene promoters. YAP is mainly described as a transcriptional activator of genes involved in cell proliferation and survival. Using a genome-wide approach, we show here that, in addition to its known function as a transcriptional activator, YAP functions as a transcriptional repressor by interacting with the multifunctional transcription factor Yin Yang 1 (YY1) and Polycomb repressive complex member enhancer of zeste homologue 2 (EZH2). YAP colocalized with YY1 and EZH2 on the genome to transcriptionally repress a broad network of genes mediating a host of cellular functions, including repression of the cell-cycle kinase inhibitor p27, whose role is to functionally promote contact inhibition. This work unveils a broad and underappreciated aspect of YAP nuclear function as a transcriptional repressor and highlights how loss of contact inhibition in cancer is mediated in part through YAP repressive function. Significance: This study provides new insights into YAP as a broad transcriptional repressor of key regulators of the cell cycle, in turn influencing contact inhibition and tumorigenesis.
FLEXIBLE ENDOSCOPIC TREATMENT FOR ZENKER’S DIVERTICULUM: RESULTS OF OUR 44 CONVENTIONAL INTERVENTIONS
Authors: Á Orbán-Szilágyi, T Bakucz, T Gyökeres
Journal: Endoscopy (2020)

Aims Flexible endoscopic myotomy (FEM) of the cricopharyngeal muscle is a widely used technique in the treatment of symptomatic Zenker’s diverticulum. It is considered to be safe and effective. Nowadays a new endoscopic technique using submucosal tunneling method (Z-POEM) has been introduced. Until now, no clear advantage of this new technique has been confirmed.
SINGLE-STEP ERCP PLUS EUS-GUIDED GALLBLADDER DRAINAGE THROUGH LAMS FOR CHOLECYSTOLITHIASIS WITH ACUTE CHOLECYSTITIS AND CONCOMITANT CHOLEDOCHOLITHIASIS, IN PATIENTS UNFIT FOR SURGERY
Authors: A Ciccone, G Valerii, C Baldassarre, G Marchetti, G Cappello, D Gabrieli, F Ciccone, C Barbera
Journal: Endoscopy (2020)

Aims Endoscopic retrograde cholangiopancreatography (ERCP), followed by laparoscopic cholecystectomy, remains the gold standard for the management of cholecysto-choledocholithiasis. Laparo-endoscopic rendezvous, which combines laparoscopic cholecystectomy and ERCP at the same time, is an alternative. Recently, endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) using lumen apposing metal stents (LAMS) has been increasingly used. Furthermore, a novel dedicated fully-covered and electrocautery-enhanced LAMS (Hot AxiosTM; Boston Scientific, USA) has been developed. This study aimes to evaluate the effectiveness and safety of single-step ERCP plus EUS-GBD through LAMS for cholecysto-choledocholithiasis with acute cholecystitis in patients unfit for surgery.
Fractional Exhaled Nitric Oxide and the Peripheral Blood Eosinophil Count as Biomarkers of the Response to Mepolizumab in Patients with Severe Eosinophilic Asthma
Authors: R Shrimanker, I D Pavord, R Price, E S Bradford, O N Keene, S Yancey
Journal: American Journal of Respiratory and Critical Care Medicine (2018)
ENDOSCOPIC MICRODEBRIDER-ASSISTED NECROSECTOMY FOR WALLED-OFF PANCREATIC NECROSIS
Authors: C Schlag, M Abdelhafez, M Friedrich-Rust, T Kowalski, D Lorren, A Chiang, A Schlachtermann, U Siddiqui, E Villa, A Trindade, P Benias, J.H. Hwang, H Shahid, M Khaleh, A Tyberg, A.D. Koch, M.J. Bruno
Journal: Endoscopy (2020)

Aims Debridement of infected walled-off pancreatic necrosis (WOPN) is indicated to treat ongoing infection and sepsis-related multi-organ failure. The lack of dedicated and effective accessories results in the need for time-consuming repetitive procedures. The aim of this prospective international multicenter study is to evaluate the use of a new 3.1 mm flexible microdebrider catheter (EndoRotor) to remove solid debris under direct endoscopic visualization in patients with WOPNs.
POST-ERCP INFECTIONS CAUSED BY CONTAMINATED DUODENOSCOPES
Authors: J Kwakman, M Bruno, M Vos
Journal: Endoscopy (2020)

Aims Despite compliance to extensive reprocessing protocols, duodenoscopes have been related to multiple outbreaks of multi-drug resistant organisms (MDRO) due to persistent duodenoscope contamination. Reports of duodenoscope associated infections (DAI) usually describe outbreaks of MDRO. Outbreaks with susceptible microorganisms probably do occur, but are hard to recognize and thus underreported. We aim to find all potential DAIs that occurred in a large ERCP center within fifteen months.
Polymerase Chain Reaction for the Diagnosis of HIV Infection in Adults
Authors: Douglas K. Owens, Mark Holodniy, Alan M. Garber, John Scott, Seema Sonnad, Lincoln Moses, Bruce Kinosian, J. Sanford Schwartz
Journal: Annals of Internal Medicine (1996)

Purpose: To do a meta-analysis of studies that have evaluated the sensitivity and specificity of polymerase chain reaction (PCR) assay for the diagnosis of human immunodeficiency virus (HIV) infect...
Focal 18F-NaF PET Prostate Activity in the Setting of Prostate Adenocarcinoma
Authors: Jason Chiang, Jonathan P. Gershenson, Michael S. Lewis, Kiarash Vahidi, Gholam R. Berenji
Journal: Clinical Nuclear Medicine (2020)

Abstract A 72-year-old man with a family history of prostate cancer and initial diagnosis of favorable intermediate risk prostate cancer via biopsy in 2017 elected for active surveillance. Two years later, he underwent prostate biopsy showing intermediate-risk cT1c Nx Mx lesion with Gleason score 3 + 4 = 7 (5 core positive). Transrectal ultrasound showed a prostate volume 28 mL, and the prostate-specific antigen was 8.1. Patient elected to proceed with combination radiation therapy and androgen deprivation therapy.
Case 15-2020: A 79-Year-Old Man with Hyponatremia and Involuntary Movements of the Arm and Face
Authors: Cynthia M. Cooper, Pui W. Cheung, Ellen B. Penney, Jenny J. Linnoila
Journal: New England Journal of Medicine (2020)

A 79-year-old man was admitted to this hospital because of hyponatremia and involuntary movements, which would start in the left arm and hand and then involve the left side of the face, such that he would look as though he was grimacing. After he received treatment for hyponatremia, the involuntary movements worsened. A diagnosis was made.