tbuckley/cabot-search huggingface dataset:
TCT-345 Impact of Myocardial Bridging on Long-Term Outcomes After Heart Transplantation: Risk Stratification With IVUS-Determined Anatomical Properties
Authors: Kozo Okada, Takeshi Nishi, Shigemitsu Tanaka, Helen Luikart, Paul G. Yock, Alan C. Yeung, Kiyoshi Hibi, Kazuo Kimura, Ingela Schnittger, Kiran Khush, William Fearon, Yasuhiro Honda
Journal: Journal of the American College of Cardiology (2019)
TCT-126 Does Age Impact Infarct Size and Microvascular Obstruction After PCI in STEMI? Individual Patient Data Analysis from 7 Magnetic Resonance Imaging Studies
Authors: Ghazaleh Mehdipoor, Shmuel Chen, Aaron Crowley, Yiran Zhang, Bahira Shahim, Manesh Patel, Christopher Granger, E. Magnus Ohman, Ingo Eitel, Suzanne de Waha-Thiele, Holger Thiele, Akiko Maehara, Ori Ben-Yehuda, Gregg Stone
Journal: Journal of the American College of Cardiology (2019)
TCT-82 Long-Term Clinical Outcomes After Renal Denervation in an Asian Population: Results From the Global SYMPLICITY Registry in South Korea (GSR Korea)
Authors: Byeong-Keuk Kim, Hyo-Soo Kim, Seung-Jung Park, Chang Gyu Park, Hyeon-Cheol Gwon, Taehoon Ahn, Hyuck Moon Kwon, Martin Fahy, Yangsoo Jang
Journal: Journal of the American College of Cardiology (2019)
Assessment of Hospital Readmission Rates, Risk Factors, and Causes After Cardiac Arrest
Authors: Ilhwan Yeo, Jim W. Cheung, Dmitriy N. Feldman, Nivee Amin, John Chae, S. Chiu Wong, Luke K. Kim
Journal: JAMA Network Open (2019)

Cardiac arrest (CA) remains a global health challenge with high rates of mortality and morbidity. 1,2rthermore, recovery from CA without residual neurologic deficit is limited.Consequently, the burden of CA on the US health care system is increasing.Thirty-day readmissions are costly and associated with poor outcomes. 3However, there is a paucity of data regarding the readmission characteristics of CA, and previous studies have mostly focused on older populations. 4Therefore, further understanding of readmission after CA is needed to allow institutions to focus already limited resources and prevent unnecessary readmissions.We aimed to investigate contemporary rate, timing, causes, and risk factors associated with 30-day readmissions after CA. MethodsThis cohort study used data from the Nationwide Readmissions Database (NRD) from 2010 to 2014.Data analysis was performed from January 1, 2010, to November 30, 2014.The NRD collects annual discharge data and enables nationally representative readmission analyses. 5 All hospitalizations associated with either out-of-hospital CA or in-hospital CA were selected based on the International Classification of Diseases, Ninth Revision, Clinical Modification code 427.5.Among those with CA, ventricular tachycardia and ventricular fibrillation were identified by codes 427.1 and 427.4,respectively.Pulseless electrical activity or asystole arrests were defined as CA without concomitant ventricular arrhythmia.The primary outcome of interest was 30-day all-cause readmission.To identify independent risk factors associated with 30-day readmission following discharge after CA, we created a multivariable Cox proportional hazards regression model.The Weill Cornell Medicine institutional review board deemed this study exempt because the NRD is a publicly available database containing deidentified patient information.All analyses were performed using SAS statistical software version 9.4 (SAS Institute).All tests were 2-sided, with P < .05indicating statistical significance.This study followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline. ResultsThere were 251 346 patients who survived the CA-related index hospitalization.Median (interquartile range) age was 64.8 (53.7-75.8)years, and 106 831 participants (42.5%) were women (Table 1).Among CA survivors, 49 305 (19.6%) were readmitted within 30 days after discharge.While 30-day readmission rate was higher in the cohort with pulseless electrical activity or asystole than in the cohort with ventricular tachycardia or ventricular fibrillation (20.3% vs 18.3%; difference, 2.0%; 95% CI, 1.7%-2.4%;P < .001), the median (interquartile range) time to readmission was 9 (4-18) days for both cohorts.
Prevalence of Immunodeficiency in Children With Invasive Pneumococcal Disease in the Pneumococcal Vaccine Era
Authors: Coen Butters, Linny Kimly Phuong, Theresa Cole, Amanda Gwee
Journal: JAMA Pediatrics (2019)

Despite increasing access to vaccination, invasive pneumococcal disease (IPD) is responsible for approximately 826 000 deaths worldwide in children younger than 5 years each year. To allow early identification and prevention, an improved understanding of risk factors for IPD is needed.To review the literature on the prevalence of primary immunodeficiency (PID) in children younger than 18 years presenting with IPD without another predisposing condition and to inform guidelines for immunologic evaluation after the first episode of IPD based on published evidence.A literature search of PubMed, Embase (inception [1974] to February 28, 2019), and MEDLINE (inception [1946] to February 28, 2019) was conducted using the terms Streptococcus pneumonia, Streptococcus pneumoniae, pneumococcal infection, Streptococcus infection, pneumococcal meningitis, immunodeficiency, immune response, immunocompromised, susceptib*, precursor, predispose*, recurren*, newborn, neonat*, infan*, toddler, child, preschooler, adolescen*, and pediatric. Publications reporting original data on immunodeficiency in children with microbiologically confirmed primary or recurrent IPD were included. Strength of clinical data was graded according to the 5-point scale of the Oxford Centre for Evidence-Based Medicine.In 6022 unique children with primary IPD, 5 of 393 (1.3%) to 17 of 162 (10.5%) of all children and 14 of 53 (26.4%) of those older than 2 years had a PID identified. Higher rates of PID, up to 10 of 15 (66.7%), were found in children with recurrent IPD. Antibody deficiency was the most common immunodeficiency, followed by complement deficiency, asplenia, and rarer defects in T-cell signaling. The site of infection was a key indicator for the risk of underlying PID, with the greatest risk of PID in children with meningitis or complicated pneumonia.Results of this study suggest that invasive pneumococcal disease, and particularly recurrent IPD, is an important marker of underlying PID in children without other risk factors. The findings also suggest that children older than 2 years with pneumococcal meningitis or complicated pneumonia and all children with recurrent IPD should be referred for an immune evaluation.PROSPERO identifier: CRD42017075978.
TCT-533 New Permanent Pacemaker Implantation Does Not Affect Survival After Transcatheter Aortic Valve Replacement With Sapien-3 Valve
Authors: Yasser Sammour, Kimi Sato, Arnav Kumar, Kinjal Banerjee, Manpreet Kaur, Jay Patel, Cameron Incognito, Hassan Lak, Mohamed Gad, Keerat Rai Ahuja, Lars Svensson, Oussama Wazni, Faisal Bakaeen, Rishi Puri, Grant Reed, James Yun, Amar Krishnaswamy, Samir Kapadia
Journal: Journal of the American College of Cardiology (2019)
Taking Off the Blinders: The Critical Phase of Suicidality Doesn’t End With Discharge From Inpatient Treatment
Authors: Christian G. Huber, Stefan Borgwardt, Undine E. Lang, Andres R. Schneeberger
Journal: The American Journal of Bioethics (2019)

"Taking Off the Blinders: The Critical Phase of Suicidality Doesn’t End With Discharge From Inpatient Treatment." The American Journal of Bioethics, 19(10), pp. 93–94
Androgenic Effects on Ventricular Repolarization
Authors: Joe-Elie Salem, Tao Yang, Javid J. Moslehi, Xavier Waintraub, Estelle Gandjbakhch, Anne Bachelot, Francoise Hidden-Lucet, Jean-Sebastien Hulot, Bjorn C. Knollmann, Benedicte Lebrun-Vignes, Christian Funck-Brentano, Andrew M. Glazer, Dan M. Roden
Journal: Circulation (2019)

Male hypogonadism, arising from a range of etiologies including androgen-deprivation therapies (ADTs), has been reported as a risk factor for acquired long-QT syndrome (aLQTS) and torsades de pointes (TdP). A full description of the clinical features of aLQTS associated with ADT and of underlying mechanisms is lacking.We searched the international pharmacovigilance database VigiBase for men (n=6 560 565 individual case safety reports) presenting with aLQTS, TdP, or sudden death associated with ADT. In cardiomyocytes derived from induced pluripotent stem cells from men, we studied electrophysiological effects of ADT and dihydrotestosterone.Among subjects receiving ADT in VigiBase, we identified 184 cases of aLQTS (n=168) and/or TdP (n=68; 11% fatal), and 99 with sudden death. Of the 10 ADT drugs examined, 7 had a disproportional association (reporting odds ratio=1.4-4.7; P<0.05) with aLQTS, TdP, or sudden death. The minimum and median times to sudden death were 0.25 and 92 days, respectively. The androgen receptor antagonist enzalutamide was associated with more deaths (5430/31 896 [17%]; P<0.0001) than other ADT used for prostate cancer (4208/52 089 [8.1%]). In induced pluripotent stem cells, acute and chronic enzalutamide (25 µM) significantly prolonged action potential durations (action potential duration at 90% when paced at 0.5 Hz; 429.7±27.1 (control) versus 982.4±33.2 (acute, P<0.001) and 1062.3±28.9 ms (chronic; P<0.001), and generated afterdepolarizations and/or triggered activity in drug-treated cells (11/20 acutely and 8/15 chronically). Enzalutamide acutely and chronically inhibited delayed rectifier potassium current, and chronically enhanced late sodium current. Dihydrotestosterone (30 nM) reversed enzalutamide electrophysiological effects on induced pluripotent stem cells.QT prolongation and TdP are a risk in men receiving enzalutamide and other ADTs.URL: https://www.clinicaltrials.gov. Unique identifier: NCT03193138.
Quantitative Results of a National Intervention to Prevent Hospital-Onset Methicillin-Resistant<i>Staphylococcus aureus</i>Bloodstream Infection
Authors: David P. Calfee, Shannon Davila, Vineet Chopra, Payal K. Patel, Ashley Snyder, David Ratz, Andrew J. Rolle, Russell N. Olmsted, Kyle J. Popovich
Journal: Annals of Internal Medicine (2019)

Background: Methicillin-resistant Staphylococcus aureus (MRSA) remains one of the most common causes of health care–associated infection (HAI). Objective: To evaluate the effect of education and a tiered, evidence-based infection prevention strategy on rates of hospital-onset MRSA bloodstream infection (BSI). Design: Prospective, national, nonrandomized, interventional, 12-month, multiple cohort, pre–post observational quality improvement project. Setting: Acute care, long-term acute care, and critical access hospitals with a disproportionate burden of HAI. Patients: All patients admitted to participating facilities during the project period. Intervention: A multimodal infection prevention intervention consisting of recommendations and tools for prioritizing and implementing evidence-based infection prevention strategies, on-demand educational videos, Internet-based live educational presentations, and access to content experts. Measurements: Rates of hospital-onset MRSA BSI, overall and stratified by hospital type, during 12-month baseline and postintervention periods. Variation in outcomes across hospital types was examined. Results: Between November 2016 and May 2018, 387 hospitals in 23 states and the District of Columbia participated, 353 (91%) submitted MRSA data, and 172 (49%) indicated that MRSA prevention was a priority. Unadjusted overall rates of hospital-onset MRSA BSI were 0.075 (95% CI, 0.065 to 0.085) and 0.071 (CI, 0.063 to 0.080) per 1000 patient-days in the baseline and postintervention periods, respectively. Limitations: The intervention period was short. Participation and adherence to recommended interventions were not fully assessed. Baseline rates of hospital-onset MRSA BSI were relatively low. Prevention of MRSA was a priority in a minority of participating hospitals. Patient characteristics and other MRSA risk factors were not assessed. Conclusion: In hospitals with a disproportionate burden of HAIs, access to tools to assist with implementation of evidence-based prevention strategies and education resources alone may not be sufficient to prevent MRSA BSI. Primary Funding Source: Centers for Disease Control and Prevention.
TCT-578 Contrast Mediated FFR Plus Intracoronary Injection of Nitroglycerine: A Submaximal Hyperemic Adenosine-Free Index That Accurately Predicts FFR
Authors: Alejandro Gutierrez-Barrios, Livia L. Gheorghe, Juan Enrique Puche, Santiago Camacho Freire, Inmaculada Noval-Morillas, Elena Izaga
Journal: Journal of the American College of Cardiology (2019)
CMKLR1-targeting peptide tracers for PET/MR imaging of breast cancer
Authors: Sarah Erdmann, Lars Niederstadt, Eva Jolanthe Koziolek, Juan Daniel Castillo Gómez, Sonal Prasad, Asja Wagener, Jan Lennart von Hacht, Sandy Reinicke, Samantha Exner, Sebastian Bandholtz, Nicola Beindorff, Winfried Brenner, Carsten Grötzinger
Journal: Theranostics (2019)

Background: Molecular targeting remains to be a promising approach in oncology. Overexpression of G protein-coupled receptors (GPCRs) in human cancer is offering a powerful opportunity for tumor-selective imaging and treatment employing nuclear medicine. We utilized novel chemerin-based peptide conjugates for chemokine-like receptor 1 (CMKLR1) targeting in a breast cancer xenograft model. Methods: By conjugation with the chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), we obtained a family of five highly specific, high-affinity tracers for hybrid positron emission tomography/magnetic resonance (PET/MR) imaging. A xenograft model with target-positive DU4475 and negative A549 tumors in immunodeficient nude mice enabled CMKLR1-specific imaging in vivo. We acquired small animal PET/MR images, assessed biodistribution by ex vivo measurements and investigated the tracer specificity by blocking experiments. Results: Five CMKLR1-targeting peptide tracers demonstrated high biological activity and affinity in vitro with EC50 and IC50 values below 2 nM. Our target-positive (DU4475) and target-negative (A549) xenograft model could be validated by ex vivo analysis of CMKLR1 expression and binding. After preliminary PET imaging, the three most promising tracers [68Ga]Ga-DOTA-AHX-CG34, [68Ga]Ga-DOTA-KCap-CG34 and [68Ga]Ga-DOTA-ADX-CG34 with best tumor uptake were further analyzed. Hybrid PET/MR imaging along with concomitant biodistribution studies revealed distinct CMKLR1-specific uptake (5.1% IA/g, 3.3% IA/g and 6.2% IA/g 1 h post-injection) of our targeted tracers in DU4475 tumor tissue. In addition, tumor uptake was blocked by excess of unlabeled peptide (6.4-fold, 5.5-fold and 3.4-fold 1 h post-injection), further confirming CMKLR1 specificity. Out of five tracers, we identified these three tracers with moderate, balanced hydrophilicity to be the most potent in receptor-mediated tumor targeting. Conclusion: We demonstrated the applicability of 68Ga-labeled peptide tracers by visualizing CMKLR1-positive breast cancer xenografts in PET/MR imaging, paving the way for developing them into theranostics for tumor treatment.
Germline NPM1 mutations lead to altered rRNA 2′-O-methylation and cause dyskeratosis congenita
Authors: Daphna Nachmani, Anne H. Bothmer, Silvia Grisendi, Aldo Mele, Dietmar Bothmer, Jonathan D. Lee, Emanuele Monteleone, Ke Cheng, Yang Zhang, Assaf C. Bester, Alison Guzzetti, Caitlin A. Mitchell, Lourdes M. Mendez, Olga Pozdnyakova, Paolo Sportoletti, Maria-Paola Martelli, Tom J. Vulliamy, Modi Safra, Schraga Schwartz, Lucio Luzzatto, Olivier Bluteau, Jean Soulier, Robert B. Darnell, Brunangelo Falini, Inderjeet Dokal, Keisuke Ito, John G. Clohessy, Pier Paolo Pandolfi
Journal: Nature Genetics (2019)
Listeriosis outbreak likely due to contaminated liver pâté consumed in a tavern, Austria, December 2018
Authors: Adriana Cabal, Franz Allerberger, Steliana Huhulescu, Christian Kornschober, Burkhard Springer, Claudia Schlagenhaufen, Marianne Wassermann-Neuhold, Harald Fötschl, Peter Pless, Robert Krause, Anna Lennkh, Andrea Murer, Werner Ruppitsch, Ariane Pietzka
Journal: Eurosurveillance (2019)

In late December 2018, an outbreak of listeriosis occurred after a group of 32 individuals celebrated in a tavern in Styria, Austria; traditional Austrian food (e.g. meat, meat products and cheese) was served. After the celebration, 11 individuals developed gastrointestinal symptoms, including one case with severe sepsis. Cases had consumed mixed platters with several meat products and pâtés originating from a local production facility (company X). Human, food and environmental samples taken from the tavern and company X were tested for L. monocytogenes. Whole genome sequence-based typing detected a novel L. monocytogenes strain of serotype IVb, sequence type 4 and CT7652 in 15 samples; 12 human, two food and one environmental sample from company X with an allelic difference of 0 to 1. Active case finding identified two further cases who had not visited the tavern but tested positive for the outbreak strain. In total, 13 cases (seven females and six males; age range: 4-84 years) were identified. Liver pâté produced by company X was identified as the likely source of the outbreak. Control measures were implemented and since the end of December 2018, no more cases were detected.
TCT-652 Intravascular Lithotripsy for the Management of Undilatable Coronary Stent: The Multicenter SMILE Registry
Authors: Alfonso Ielasi, Gaetano Gioffrè, Bernardo Cortese, Salvatore Colangelo, Francesco Arioli, Fabrizio Tomai, Mauro Maioli, Giuseppe Pietro Greco Lucchina, Massimo Leoncini, Gabriele Tumminello, Matteo Pennesi, Francesco Bedogni, Maurizio Tespili
Journal: Journal of the American College of Cardiology (2019)
PSMA-targeting agents for radio- and fluorescence-guided prostate cancer surgery
Authors: Yvonne H.W. Derks, Dennis W. P. M. Löwik, J. P. Michiel Sedelaar, Martin Gotthardt, Otto C. Boerman, Mark Rijpkema, Susanne Lütje, Sandra Heskamp
Journal: Theranostics (2019)

Despite recent improvements in imaging and therapy, prostate cancer (PCa) still causes substantial morbidity and mortality.In surgical treatment, incomplete resection of PCa and understaging of possible undetected metastases may lead to disease recurrence and consequently poor patient outcome.To increase the chance of accurate staging and subsequently complete removal of all cancerous tissue, prostate specific membrane antigen (PSMA) targeting agents may provide the surgeon an aid for the intraoperative detection and resection of PCa lesions.Two modalities suitable for this purpose are radionuclide detection, which allows sensitive intraoperative localization of tumor lesions with a gamma probe, and fluorescence imaging, allowing tumor visualization and delineation.Next to fluorescence, use of photosensitizers may enable intraoperative targeted photodynamic therapy to eradicate remaining tumor lesions.Since radiodetection and optical imaging techniques each have their own strengths and weaknesses, a combination of both modalities could be of additional value.Here, we provide an overview of recent preclinical and clinical advances in PSMA-targeted radio-and fluorescence-guided surgery of PCa.
TCT-2 Paravalvular Regurgitation After Transcatheter Aortic Valve Replacement in Moderate-Risk Patients: A Pooled PARTNER 2 Trial and Registry Study
Authors: Katherine Chau, Shmuel Chen, Aaron Crowley, Philippe Pibarot, Rebecca Hahn, Pamela Douglas, Maria Alu, Matthew Finn, Susheel Kodali, Wael Jaber, L. Leonardo Rodriguez, Vinod Thourani, Martin Leon
Journal: Journal of the American College of Cardiology (2019)
Alcohol Consumption and Risk of Dementia and Cognitive Decline Among Older Adults With or Without Mild Cognitive Impairment
Authors: Manja Koch, Annette L. Fitzpatrick, Stephen R. Rapp, Richard L. Nahin, Jeff D. Williamson, Oscar L. Lopez, Steven T. DeKosky, Lewis H. Kuller, Rachel H. Mackey, Kenneth J. Mukamal, Majken K. Jensen, Kaycee M. Sink
Journal: JAMA Network Open (2019)

Substantial heterogeneity and uncertainty exist in the observed associations between alcohol consumption and dementia.To assess the association between alcohol consumption and dementia and the roles of mild cognitive impairment (MCI) and apolipoprotein E ε4 (APOE E4) genotype in modifying this association.This cohort study used data from the Ginkgo Evaluation of Memory Study, conducted from 2000 to 2008 among US community-dwelling participants. This study analyzed 3021 participants aged 72 years and older who were free of dementia. Data analysis was performed from 2017 to 2018.Self-reported alcohol consumption, drinking frequency, and quantity.Using multivariable proportional hazards regression and linear mixed models, the risk of dementia and the rate of change over time in the Modified Mini-Mental State Examination were estimated.Among 3021 participants, the median (interquartile range) age was 78 (76-80) years; 1395 (46.2%) were female. During a median (interquartile range) follow-up of 6.0 (4.9-6.5) years, 512 cases of dementia occurred. For 7.1 to 14.0 drinks per week compared with less than 1.0 drink per week, the hazard ratios for dementia were 0.63 (95% CI, 0.38-1.06) among 2548 participants without MCI and 0.93 (95% CI, 0.47-1.84) among 473 participants with MCI. Among participants with MCI, the hazard ratio for dementia was 1.72 (95% CI, 0.87-3.40) for more than 14.0 drinks per week compared with less than 1.0 drink per week. The association of alcohol intake with dementia differed for participants with and without baseline MCI (P for interaction = .03). Among participants without MCI, daily low-quantity drinking was associated with lower dementia risk than infrequent higher-quantity drinking (hazard ratio, 0.45; 95% CI, 0.23-0.89; P = .02). Findings were consistent when stratified by sex, age, and APOE E4 genotype. Compared with drinking less than 1.0 drink per week, complete abstention (in participants without MCI) and the consumption of more than 14.0 drinks per week (in participants with MCI) were associated with lower Modified Mini-Mental State Examination scores (mean difference at follow-up compared with baseline, -0.46 point [95% CI, -0.87 to -0.04 point] and -3.51 points [95% CI, -5.75 to -1.27 points], respectively).In this study, complete abstention and consuming more than 14.0 drinks per week (compared with drinking <1.0 drink per week) were associated with lower cognitive scores among participants aged 72 years and older. Particular caution is needed among individuals with MCI who continue to drink alcohol.
TCT-119 Reduced Mortality in Severe PE With Ultrasound-Assisted Catheter-Directed Thrombolysis: A Single-Center Experience
Authors: Shayan Nabavi Nouri, Mahesh Madhavan, Michael Lavelle, Heidi Lumish, Jianhua Li, Erika Berman-Rosenzweig, Sahil A. Parikh, Ajay Jayant Kirtane, Arthur Garan, Justin Fried, Daniel Brodie, Cara Agerstrand, Sanjum Sethi, Philip Green
Journal: Journal of the American College of Cardiology (2019)
TCT-282 Predictors of Clinical Outcomes After Implantation of Novel Sirolimus-Eluting Stent in Real-World Patient Population
Authors: Sameer Dani, Devang Desai, Rashmit Pandya, Pritesh Parekh, Apurva Vasavada, Nirav Bhalani, Arvind Sharma, Chirag Sheth, Dinesh Shah
Journal: Journal of the American College of Cardiology (2019)
Erratum: Waldenström's macroglobulinaemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (Annals of oncology : official journal of the European Society for Medical Oncology (2018) 29 Suppl 4 (iv41-iv50))
Authors: E. Kastritis, V. Leblond, M. A. Dimopoulos, E. Kimby, P. Staber, M. J. Kersten, A. Tedeschi, C. Buske
Journal: Annals of Oncology (2018)
TCT-319 Impact of Percutaneous Ventricular Assist Device Utilization Volume During Percutaneous Coronary Intervention in Noncardiogenic Shock Patients on 30-Day Readmission Rate: A Nationwide Cohort Study
Authors: Yasser Al-Khadra, Fahed Darmoch, Homam Moussa Pacha, Mohamad Soud, M. Chadi Alraies
Journal: Journal of the American College of Cardiology (2019)