tbuckley/cabot-search huggingface dataset:
FULLY COVERED SELF EXPANDABLE METAL STENT IN THE MANAGEMENT OF DIFFICULT CHOLEDOCOLITIASIS
Authors: G Grande, A Caruso, F Pigò, H Bertani, S Mangiafico, R Conigliaro
Journal: Endoscopy (2019)

Difficult choledocholithiasis represents up to 15% of retained biliary stones and no standard treatment is codified. On this context, the temporary use of fully covered self expandable metal stent (FCSEMS) are an emergent option. Our aim was to assess the efficacy and safety of FCSEMS in the treatment of difficult common bile duct (CBD) stones.
Causal Factors for Knee, Hip, and Hand Osteoarthritis: A Mendelian Randomization Study in the <scp>UK</scp> Biobank
Authors: Thomas Funck‐Brentano, Maria Nethander, Sofia Movérare‐Skrtic, Pascal Richette, Claes Ohlsson
Journal: Arthritis & Rheumatology (2019)

There is no curative treatment for osteoarthritis (OA), which is the most common form of arthritis. This study was undertaken to identify causal risk factors of knee, hip, and hand OA.Individual-level data from 384,838 unrelated participants in the UK Biobank study were analyzed. Mendelian randomization (MR) analyses were performed to test for causality for body mass index (BMI), bone mineral density (BMD), serum high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglyceride levels, type 2 diabetes, systolic blood pressure (BP), and C-reactive protein (CRP) levels. The primary outcome measure was OA determined using hospital diagnoses (all sites, n = 48,431; knee, n = 19,727; hip, n = 11,875; hand, n = 2,330). Odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated.MR analyses demonstrated a robust causal association of genetically determined BMI with all OA (OR per SD increase 1.57 [95% CI 1.44-1.71]), and with knee OA and hip OA, but not with hand OA. Increased genetically determined femoral neck BMD was causally associated with all OA (OR per SD increase 1.14 [95% CI 1.06-1.22]), knee OA, and hip OA. Low systolic BP was causally associated with all OA (OR per SD decrease 1.55 [95% CI 1.29-1.87]), knee OA, and hip OA. There was no evidence of causality for the other tested metabolic factors or CRP level.Our findings indicate that BMI exerts a major causal effect on the risk of OA at weight-bearing joints, but not at the hand. Evidence of causality of all OA, knee OA, and hip OA was also observed for high femoral neck BMD and low systolic BP. However, we found no evidence of causality for other metabolic factors or CRP level.
Abstract 14959: Electrophysiological Characteristics in Different Types of Univentricular Physiology
Authors: Akiko Ueda, Irina Horduna, Lilian Mantziari, Procolo Marchese, Marko Gujic, Beatrice Bonello, Sonya V Babu-Narayan, Siew Y Ho, Sabine Ernst
Journal: Circulation (2012)

Background Both classic Fontan (right atrium (RA) to pulmonary artery (PA)) and total cavopulmonary connection (TCPC) are surgical options for physiological univentricular heart. Although demographic analysis has shown that TCPC provides better long-term outcome than classical Fontan in terms of supraventricular tachycardia (SVT) occurrence, little is known about electrophysiological characteristics after these surgeries. The aim of this study was to assess clinical and electrophysiological differences in patients with these two types of operations. Methods A total of 37 procedures in 25 patients with univentricular physiology who underwent catheter ablation procedures using electroanatomic mapping system (EAM) were enrolled. The patients comprised of two groups; 1) classical Fontan (group A; 26 procedures in 17 patients, median age 31 yrs, male 10) and 2) TCPC (group B; 11 procedures in 8 patients, median age 24 yrs, male 6). Electrophysiological characteristics and procedural data were compared. Results...
Clinical and endoscopic aspects of metastases to the gastrointestinal tract
Authors: Luiza Haendchen Bento, Mauricio Kazuyoshi Minata, Clelma Pires Batista, Bruno da Costa Martins, Luciano Henrique Lenz Tolentino, Rodrigo Corsato Scomparim, Fábio Shiguehissa Kawaguti, Carla Cristina Gusmon de Oliveira, Marcelo Simas de Lima, Sebastian Naschold Geiger, Elisa Ryoka Baba, Adriana Safatle-Ribeiro, Ulysses Ribeiro Jr, Fauze Maluf-Filho
Journal: Endoscopy (2019)

Abstract Background Studies that describe metastases to the gastrointestinal (GI) tract are restricted to small case series. An increase in the frequency of this condition is expected, so it would be useful to better characterize the endoscopic aspects of metastasis to the GI tract. The aims of this study were to describe the frequency and endoscopic features of the lesions, and to analyze the survival rate after diagnosis of metastasis. Methods This was a retrospective, single-center, observational study, conducted between 2009 and 2017. Patients with metastasis to the GI tract were included. Results 95 patients were included. Melanoma (25.3 %), lung (15.8 %), and breast (14.7 %) were the most frequent primary tumors. The most common endoscopic presentation was a solitary, ulcerated lesion in the gastric body. Conventional biopsy was diagnostic in 98.9 % of the cases. The mean and median survival rates were 13.3 months (95 % confidence interval [CI] 8.2 – 18.3) and 4.7 months (95 %CI 3.7 – 5.6), respectively. Palliative treatment with chemo- and/or radiotherapy after the diagnosis of the metastasis was related to a higher survival rate. Conclusions Melanoma, lung, and breast cancer were the most common primary tumors to metastasize to the GI tract. The endoscopic features could not predict the primary site of the tumor. The finding of metastasis in the GI tract is related to the final stage of the cancer disease but patients who received palliative treatment with chemo- and/or radiotherapy after diagnosis of GI metastasis had higher survival rates.
APPLICATION OF TWO SCORES TO PREDICT AND STRATIFY THE RISK OF RESIDUAL OR RECURRING ADENOMA AFTER PIECEMEAL EMR OF NON-PEDUNCULATED COLORECTAL POLYPS
Authors: G Alexandrino, T Dias Domingues, L Martins Figueiredo, LC Lourenço, R Carvalho, J Reis
Journal: Endoscopy (2019)

In 15 – 20% of colorectal EMR residual or recurring adenoma (RRA) is found at follow-up colonoscopy. The SERT score was recently developed to identify lesions most likely to recur. The SMSA score predicts difficulty in achieving endoscopic success after polypectomy. Our aim was to evaluate and compare prospectively the efficacy of these scores in identifying individually for each lesion the risk of RRA.
Use and duration of chemotherapy (CT) in patients (pts) with metastatic breast cancer (MBC) according to tumor subtype (TS) and line of therapy (tx).
Authors: Davinia Shien Seah, Ines Maria Vaz Duarte Luis, Erin Macrae Olson, Jessica Sohl, Georgia Litsas, Eric Winer, Nancy U. Lin, Harold J. Burstein
Journal: Journal of Clinical Oncology (2012)

6089 Background: Benefits of CT vary widely in MBC pts. We aimed to describe the impact of breast cancer TS and line of tx on the duration of CT. Methods: In a retrospective analysis, we identified 205 pts treated with CT for MBC at the Dana-Farber Cancer Institute between 2005-8. TS were classified as hormone receptor (HR)+ (ER+/PR+/HER2-), triple negative (TN) (ER-/PR-/HER2-) or HER2+ (HER2+, any HR). CT duration was defined as "time from start of one CT line to the start of the next CT." Chi-square, Kruskal-Wallis, and Kaplan-Meier methods were used. Results: Median follow-up was 54 months (m). Most pts had received adjuvant tx, though 23% had MBC at diagnosis. Almost all HER2+ pts had concurrent anti-HER2 tx. CT duration was longest in 1st line with consecutive stepwise decrease. The proportion of pts who received CT beyond the 3rd line varied by TS: 52% of HER2+ pts received &gt; 4 CT lines, compared with 37% of HR+ and 29% of TN pts. Duration in later CT lines also differed by TS. Median CT duration in HER2+ pts was &gt; 4 m in all 6 lines, but HR+ and TN pts had a median CT duration of &lt;4m from the 4th line onwards. Quartile estimates suggested a substantial fraction of HER2+ and HR+ pts receiving &gt;6m of CT in 5th and 6th line; by contrast, CT duration for TN pts were consistently brief in later CT lines. Conclusions: TS determines the likely duration and number of lines of CT for MBC. Among HR+ and HER2+ pts who receive CT beyond 3rd line, there are substantial rates of prolonged tx suggesting clinical benefit. For TN pts, the opportunity for additional lines and the CT duration declined more dramatically. The true role of advanced (&gt; 3rd) CT lines for all MBC in improving quality of life, survival, and the predictors of such benefit, warrant further study. [Table: see text]
Abstract 3578: Androgen receptor transcriptionally targets the ErbB3 regulator Nrdp1 in the presence of nuclear Filamin A.
Authors: Rosalinda M. Savoy, Liqun Chen, Salma Siddiqui, Frank U. Melgoza, Blythe Durbin-Johnson, Mohana Roy, Maitreyee K. Jathal, Swagata Bose, Yu Wang, Benjamin Mooso, Leandro D'Abronzo, William H. Fry, Kermit L. Carraway, Paramita M. Ghosh
Journal: Cancer Research (2013)

Abstract Despite availability of improved androgen receptor (AR) inhibitors for the treatment of castration-resistant prostate cancer (CRPC), resistance to treatment develops, and has been traced to activation of multiple signaling pathways suppressed by the AR. We previously showed that the AR maintained castration sensitivity in prostate cancer (PCa) by transcriptional regulation of the E3 ubiquitin ligase Nrdp1, which degrades the receptor tyrosine kinase (RTK) ErbB3; whereas AR inhibition suppressed Nrdp1 levels, thereby activating ErbB3. This resulted in CRPC growth and AR stimulation, but in CRPC, the AR was unable to regulate Nrdp1 or suppress ErbB3, causing uncontrolled progression. Here, we investigate the mechanism by which the AR regulates Nrdp1 transcription and why this regulation is lost in CRPC. Immunohistochemical studies in human PCa tissue and in PCa mouse models demonstrated Nrdp1 localization in both nucleus and cytoplasm. In vitro studies determined cytoplasmic Nrdp1 as 36kDa while nuclear Nrdp1 is 28kDa, the 36kDa form, but not the 28kDa form, negatively correlated with ErbB3 levels, but both forms positively correlated with AR. We demonstrate that Nrdp1 is a direct transcriptional target of the AR in androgen-dependent cells expressing a truncated form of the structural protein Filamin A (FlnA) in the nucleus, but in CRPC cells which have lost nuclear FlnA expression, the AR is no longer able to bind to the Nrdp1 promoter. Restoration of nuclear FlnA restored the ability of AR to regulate Nrdp1 transcription. Thus dual targeting of ErbB3 and AR will be effective in patients whose tumors express nuclear FlnA. Citation Format: Rosalinda M. Savoy, Liqun Chen, Salma Siddiqui, Frank U. Melgoza, Blythe Durbin-Johnson, Mohana Roy, Maitreyee K. Jathal, Swagata Bose, Yu Wang, Benjamin Mooso, Leandro D'Abronzo, William H. Fry, Kermit L. Carraway, Paramita M. Ghosh. Androgen receptor transcriptionally targets the ErbB3 regulator Nrdp1 in the presence of nuclear Filamin A. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3578. doi:10.1158/1538-7445.AM2013-3578
Long-Term Exposure to Road Traffic Noise and Incidence of Diabetes in the Danish Nurse Cohort
Authors: Jeanette Therming Jørgensen, Elvira Vaclavik Bräuner, Claus Backalarz, Jens Elgaard Laursen, Torben Holm Pedersen, Steen Solvang Jensen, Matthias Ketzel, Ole Hertel, Søren Nyman Lophaven, Mette Kildevæld Simonsen, Zorana Jovanovic Andersen
Journal: Environmental Health Perspectives (2019)

Background: Evidence on the association between road traffic noise and diabetes risk is sparse and inconsistent with respect to how confounding by air pollution was treated. Objectives: In this study, we aimed to examine whether long-term exposure to road traffic noise over 25 years is associated with incidence of diabetes, independent of air pollution. Methods: A total of 28,731 female nurses from the Danish Nurse cohort (&gt;44 years old at recruitment in 1993 or 1999) were linked to the Danish National Diabetes Register with information on incidence of diabetes from 1995 until 2013. The annual mean weighted levels of 24-h average road traffic noise (Lden) at nurses’ residences from 1970 until 2013 were estimated with the Nord2000 method and annual mean levels of particulate matter (PM) with diameter &lt;2.5 and 10 nm (PM2.5 and PM10), nitrogen dioxide (NO2), and nitrogen oxide (NOx) with the Danish AirGIS modeling system. Cox proportional hazards regression models were used to examine the association between residential Lden in four different exposure windows (1-, 5-, 10-, and 25-years) and the incidence of diabetes, adjusted for lifestyle factors and air pollutants. Results: Of 23,762 nurses free of diabetes at the cohort baseline, 1,158 developed diabetes during a mean follow-up of 15.2 years. We found weak positive associations between 5-y mean exposure to Lden (per 10 dB increase) and diabetes incidence in a crude model [hazard ratio (HR): 1.07; 95% confidence interval (CI): 0.99, 1.12], which attenuated in a model adjusted for lifestyle factors (HR:1.04; 95% CI: 0.97, 1.12), and reached unity after additional adjustment for PM2.5 (HR: 0.99; 0.91, 1.08). In analyses by level of urbanization, we found a positive association between noise and diabetes in urban areas (HR:1.27; 95% CI: 0.98, 1.63) that was unchanged after adjusting for PM2.5 (HR: 1.25; 95% CI: 0.97, 1.62), but we found no apparent association in provincial (HR: 1.02; 95% CI: 0.88, 1.18) or rural areas (HR: 0.97; 95% CI: 0.87, 1.08). Conclusion: In the nationwide cohort of Danish nurses 44 years of age and older, we found no association between long-term exposure to road traffic noise and diabetes incidence after adjustment for PM2.5 but found suggestive evidence of an association limited to urban areas. https://doi.org/10.1289/EHP4389
ACCURACY OF ARTIFICAL INTELLIGENCE BASED DECISION SUPPORT SYSTEM COMBINED WITH BASIC CLASSIFICATION IN COLON POLYP DETERMINATION
Authors: L Madacsy, K Zsobrak, P Schmiedt, M Szalai, L Oczella, B Dorottya Lovasz, Z Dubravcsik
Journal: Endoscopy (2019)

All colon polyps have to be removed for histological analysis due to regulatory reasons, causing real health care burden. Virtual-chromoendoscopy only in expert hands may be used for real-time diagnosis of polyp characteristics to support resect and discard strategy. In our present study, we aimed to develop an Artificial Intelligence-based Decision Support System (AI-DSS) that can assist the decision of endoscopist in the real-time determination of sub-centimetric polyp's histology with high accuracy.
UPPER GASTROINTESTINAL TRACT INVOLVEMENT IN PEDIATRIC CROHN'S DISEASE: A SINGLE-CENTER EXPERIENCE
Authors: HJ Kim, SH Oh, KM Kim
Journal: Endoscopy (2019)

Crohn's disease (CD) may involve any part of the intestine, but the prevalence of upper gastrointestinal (UGI) lesions has greatly varied. This aim of this study was to evaluate the prevalence and associated factors of UGI involvement in pediatric CD.
Assessment of Treatment Response by 99mTc-MIP-1404 SPECT/CT
Authors: Christian Schmidkonz, Michael Cordes, Michael Beck, Theresa Ida Goetz, Daniela Schmidt, Olaf Prante, Tobias Bäuerle, Alexander Cavallaro, Michael Uder, Bernd Wullich, Peter Goebell, Torsten Kuwert, Philipp Ritt
Journal: Clinical Nuclear Medicine (2018)

We investigated the role of Tc-MIP-1404 (Progenics Pharmaceuticals, Inc, New York, NY) SPECT/CT of PSMA expression in the assessment of treatment response in patients with metastatic prostate cancer.We retrospectively analyzed Tc-MIP-1404 SPECT/CT scans from 28 patients with metastatic prostate cancer examined before initiation and after completion of therapy. Eight of these patients had been treated with androgen deprivation therapy, 10 with docetaxel, and another 10 with external beam radiotherapy. On the CT images from SPECT/CT, treatment response was assessed according to RECIST 1.1 criteria; independently from that analysis, maximal standardized uptake values (SUVmax) were quantified in representative tumor lesions and treatment response assumed at differences in SUVmax greater than 30%. Radiographic response assessment was correlated to biochemical response (BR) based on prostate-specific antigen serum levels.The concordance rate between SPECT and BR was 75% (95% confidence interval [CI], 0.55-0.89) (Cohen κ = 0.57; 95% CI, 0.29-0.85; P ≤ 0.01), higher than for that between SPECT and CT with 57% (95% CI, 0.37-0.76) (κ = 0.40; 95% CI, 0.14-0.65; P ≤ 0.01), as well as that between CT and BR with 50% (95% CI, 0.31-0.69) (κ = 0.31; 95% CI, 0.06-0.57, P ≤ 0.05). Discordant findings between SPECT and CT were most likely due to limitations of CT in assessing metastases in lymph nodes, as well as bone involvement, which was sometimes not detectable on CT scans.The high agreement between treatment response, as assessed by Tc-MIP-1404 SPECT/CT and BR, suggests a possible role of that imaging tool for monitoring treatment in metastatic prostate cancer. Larger, ideally prospective trials are needed to help to reveal the full potential of SPECT imaging of PSMA expression in that regard.
Responsiveness of the EuroQol 5‐Dimension 3‐Level instrument, Dermatology Life Quality Index ( <scp>DLQI</scp> ) and <scp>DLQI</scp> ‐Relevant for patients with psoriasis in the U.S.A.
Authors: J.S. Barbieri, J.M. Gelfand
Journal: British Journal of Dermatology (2019)
NARROW-BAND IMAGING PREDICTS THE HISTOLOGY OF ANAL SQUAMOUS INTRAEPITHELIAL LESION AND SUPERFICIALLY INVASIVE SQUAMOUS CELL CARCINOMA WITH HIGH ACCURACY
Authors: G Gizzi, V Villani, L Frazzoni, G Tamanini, M La Marca, L Fuccio
Journal: Endoscopy (2019)

Anal cancer incidence is increasing. Squamous cell carcinoma is the most frequent histologic type and is preceded by precancerous lesions, i.e. squamous intraepithelial lesions (SILs), and by superficially invasive squamous cell carcinoma (SISCCA), a microinvasive disease with low metastatic risk. SIL and SISCCA are amenable to conservative or excisional treatment, however their endoscopic identification is challenging. We aimed at assessing narrow-band imaging (NBI) in predicting histology of SIL and SISCCA.
Comment on Evron et al. Changes in Screening Practices for Prediabetes and Diabetes Since the Recommendation for Hemoglobin A1c Testing. Diabetes Care 2019;42:576–584
Authors: Lioubov Stankevich, Jean-Philippe Galhaud, Roman Kuvshinov, Catherine Helmer, Pauline Poupon, Laurence Blanco, Marie Monlun, Ninon Foussard, Kamel Mohammedi, Vincent Rigalleau
Journal: Diabetes Care (2019)

We were interested by the recent article from Evron et al. (1). Based on the results of 12,772 eligible patients, the authors reported a 78% screening rate during 2010–2013 ( N = 9,941 screened), which is higher than the reported 69% (2) before the 2010 American Diabetes Association HbA1c screening recommendation. In France, as in some other countries (3), HbA1c is not recommended for screening, but it is popular among general practitioners as the 5.7–6.5% thresholds (4) are mentioned on laboratory reports. How much does this HbA1c-based screening expand, and what are the results?

The LABEXA consortium is the biggest laboratory group in New Aquitaine; it comprises three laboratories and 77 blood collecting points distributed in the …
Atorvastatin enhances the therapeutic efficacy of mesenchymal stem cells-derived exosomes in acute myocardial infarction via up-regulating long non-coding RNA H19
Authors: Peisen Huang, Li Wang, Qing Li, Xiaqiu Tian, Jun Xu, Junyan Xu, Yuyan Xiong, Guihao Chen, Haiyan Qian, Chen Jin, Yuan Yu, Ke Cheng, Li Qian, Yuejin Yang
Journal: Cardiovascular Research (2019)

Abstract Aims Naturally secreted nanovesicles, known as exosomes, play important roles in stem cell-mediated cardioprotection. We have previously demonstrated that atorvastatin (ATV) pretreatment improved the cardioprotective effects of mesenchymal stem cells (MSCs) in a rat model of acute myocardial infarction (AMI). The aim of this study was to investigate if exosomes derived from ATV-pretreated MSCs exhibit more potent cardioprotective function in a rat model of AMI and if so to explore the underlying mechanisms. Methods and results Exosomes were isolated from control MSCs (MSC-Exo) and ATV-pretreated MSCs (MSCATV-Exo) and were then delivered to endothelial cells and cardiomyocytes in vitro under hypoxia and serum deprivation (H/SD) condition or in vivo in an acutely infarcted Sprague-Dawley rat heart. Regulatory genes and pathways activated by ATV pretreatment were explored using genomics approaches and functional studies. In vitro, MSCATV-Exo accelerated migration, tube-like structure formation, and increased survival of endothelial cells but not cardiomyocytes, whereas the exosomes derived from MSCATV-Exo-treated endothelial cells prevented cardiomyocytes from H/SD-induced apoptosis. In a rat AMI model, MSCATV-Exo resulted in improved recovery in cardiac function, further reduction in infarct size and reduced cardiomyocyte apoptosis compared to MSC-Exo. In addition, MSCATV-Exo promoted angiogenesis and inhibited the elevation of IL-6 and TNF-α in the peri-infarct region. Mechanistically, we identified lncRNA H19 as a mediator of the role of MSCATV-Exo in regulating expression of miR-675 and activation of proangiogenic factor VEGF and intercellular adhesion molecule-1. Consistently, the cardioprotective effects of MSCATV-Exo was abrogated when lncRNA H19 was depleted in the ATV-pretreated MSCs and was mimicked by overexpression of lncRNA H19. Conclusion Exosomes obtained from ATV-pretreated MSCs have significantly enhanced therapeutic efficacy for treatment of AMI possibly through promoting endothelial cell function. LncRNA H19 mediates, at least partially, the cardioprotective roles of MSCATV-Exo in promoting angiogenesis.
CLINICAL OUTCOMES OF RECTAL NEUROENDOCRINE TUMORS TREATED BY ESMR-L
Authors: M Takita, K Ohata, N Matsuhashi
Journal: Endoscopy (2019)

The therapeutic strategies for the rectal neuroendocrine tumor (NET) have not been still established. We often use endoscopic submucosal resection with ligation device (ESMR-L) for treatment of rectal NET. We conducted this study to evaluate the clinical outcomes of rectal NET treated by ESMR-L.
ASSOCIATED FACTORS WITH ABSCENSE OF BILE DUCT STONE AT ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY (ERCP) IN PATIENTS WITH CHOLEDOCHOLITHIASIS DOCUMENTED ON MAGNETIC RESONANCE CHOLANGIOPANCREATOGRAPHY (MRCP)
Authors: R Palos-Cuellar, E Murcio-Pérez, A Ferreira-Hermosillo, OM Solórzano-Pineda, G Blanco-Velasco, OV Hernández-Mondragón
Journal: Endoscopy (2019)

Determine factors associated with abscense of bile duct stone at ERCP in patients with choledocholithiasis documented on MRCP.
ERCP WITH DRILLING USING SOHENDRA EXTRACTOR FOR STENTING NARROW AND IMPASSABLE MAIN DUCT STRICTURES IN CHRONIC CALCIFYING PANCREATITIS: A LARGE RETROSPECTIVE STUDY
Authors: JM Gonzalez, JP Le Mouel, M Barthet
Journal: Endoscopy (2019)

The management of symptomatic chronic pancreatitis (CP) requires stenting of the main pancreatic duct (MPD), to calibrate strictures, sometimes non crossable except by the wire. We describe our experience using Sohendra extractor to cross the obstruction for stent placement. The objectives were: to assess the technical success (ability to place a stent), and to elucidate the characteristics of the management, the factor associated with failure, and the complications.
IMPACT OF ANTIBIOTIC PROPHYLAXIS AND CONDITIONING MODALITIES DURING THE REALIZATION OF ENDOSCOPIC ORAL MYOTOMY FOR ESOPHAGEAL MOTOR DISORDERS
Authors: A Hastier-De Chelle, R Olivier, I Bentellis, M Pioche, T Piche, T Ponchon, E Coron, JM Gonzalez, M Barthet, G Vanbiervliet
Journal: Endoscopy (2019)

No guidelines regarding antibiotic prophylaxis, preparation and packaging are available in patients with esophageal motor disorders benefiting from per endoscopic oral myotomy (POEM). The main purpose of our study was to evaluate the impact of antibiotic prophylaxis on the POEM's safety.