tbuckley/cabot-search huggingface dataset:
Effect of acute hypoxia on vascular responsiveness in man
Authors: Donald D. Heistad, Robert C. Wheeler
Journal: Journal of Clinical Investigation (1970)

An effect of hypoxemia on vascular responsiveness and blood pressure regulation has not been demonstrated in man. The response of forearm resistance vessels to several vasoconstrictor stimuli was compared during normoxia and acute hypoxia. Forearm vasoconstrictor responses to lower body negative pressure and to the application of ice to the forehead, which are neurogenic stimuli, were decreased during acute hypoxia. Lower body negative pressure caused a decrease in mean arterial pressure during hypoxia, but not during normoxia. Because norepinephrine is the neurotransmitter released during reflex vasoconstriction, we considered the possibility that decreased responsiveness to norepinephrine might be one mechanism for diminished responses to lower body negative pressure and ice on the forehead during hypoxia. Hypoxia decreased the response of forearm resistance vessels to infusions of norepinephrine and angiotensin into the brachial artery. In addition, the effectiveness of intravenous infusions of norepinephrine in elevating mean arterial pressure was decreased during hypoxia. Since exposure to acute hypoxia stimulates hyperventilation and hypocapnia, experiments were done to determine the contribution of hypocapnia during hypoxia to the decreased vasoconstriction. The results indicate that hypocapnia may diminish the vascular response to some stimuli, but the reduction in oxygen appears to be the primary mechanism for decreased vasoconstrictor responses during acute hypoxia.
Label-Free Raman Spectroscopy Reveals Signatures of Radiation Resistance in the Tumor Microenvironment
Authors: Santosh K. Paidi, Paola Monterroso Diaz, Sina Dadgar, Samir V. Jenkins, Charles M. Quick, Robert J. Griffin, Ruud P.M. Dings, Narasimhan Rajaram, Ishan Barman
Journal: Cancer Research (2019)

Abstract Delay in the assessment of tumor response to radiotherapy continues to pose a major challenge to quality of life for patients with nonresponsive tumors. Here, we exploited label-free Raman spectroscopic mapping to elucidate radiation-induced biomolecular changes in tumors and uncovered latent microenvironmental differences between treatment-resistant and -sensitive tumors. We used isogenic radiation-resistant and -sensitive A549 human lung cancer cells and human head and neck squamous cell carcinoma (HNSCC) cell lines (UM-SCC-47 and UM-SCC-22B, respectively) to grow tumor xenografts in athymic nude mice and demonstrated the molecular specificity and quantitative nature of Raman spectroscopic tissue assessments. Raman spectra obtained from untreated and treated tumors were subjected to chemometric analysis using multivariate curve resolution-alternating least squares (MCR-ALS) and support vector machine (SVM) to quantify biomolecular differences in the tumor microenvironment. The Raman measurements revealed significant and reliable differences in lipid and collagen content postradiation in the tumor microenvironment, with consistently greater changes observed in the radiation-sensitive tumors. In addition to accurately evaluating tumor response to therapy, the combination of Raman spectral markers potentially offers a route to predicting response in untreated tumors prior to commencing treatment. Combined with its noninvasive nature, our findings provide a rationale for in vivo studies using Raman spectroscopy, with the ultimate goal of clinical translation for patient stratification and guiding adaptation of radiotherapy during the course of treatment. Significance: These findings highlight the sensitivity of label-free Raman spectroscopy to changes induced by radiotherapy and indicate the potential to predict radiation resistance prior to commencing therapy.
EXAMINING THE ASSOCIATION BETWEEN FRAILTY AND ORAL ANTICOAGULANT USE FOR ATRIAL FIBRILLATION: DATA FROM A CONTEMPORARY AMBULATORY VA COHORT
Authors: Saket Sanghai, Victoria Wang, Adam Rose, Hong Yu, Weisong Liu, Kelly Cho, Jane Driver, Ariela Orkaby, Jane Saczynski, David McManus
Journal: Journal of the American College of Cardiology (2019)
Diet and Depression—From Confirmation to Implementation
Authors: Michael Berk, Felice N. Jacka
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
WHOLE EXOME SEQUENCING IDENTIFIES KNOWN AND UNKNOWN GENES ASSOCIATED WITH MITRAL VALVE PROLAPSE
Authors: Aniek Van Wijngaarden, Yasmine L. Hiemstra, Tamara T. Koopmann, Claudia A.L. Ruivenkamp, Emmelien Aten, Jeroen J. Bax, Victoria Delgado, Daniela Q.C.M. Barge-Schaapveld, Nina Ajmone Marsan
Journal: Journal of the American College of Cardiology (2019)
ACTIVATION OF MIR-145/P70S6K1/ENOS PATHWAY IN MICROVASCULAR ENDOTHELIAL CELLS BY TONGXINLUO ALLEVIATES MYOCARDIAL ISCHEMIA/REPERFUSION INJURY-ROLE OF EXOSOMAL LINC-ROR FROM CARDIOMYOCYTES
Authors: Guihao Chen, Yuejin Yang, Ruijie Tang, Cunrong Huang
Journal: Journal of the American College of Cardiology (2019)
ASSOCIATION BETWEEN LEFT ATRIAL STRAIN AND SUBCLINICAL ATRIAL FIBRILLATION IN PATIENTS WITH CRYPTOGENIC STROKE: THE SURPRISE ECHO SUBSTUDY
Authors: Flemming Javier Olsen, Louisa M. Christensen, Derk W. Krieger, Søren Højberg, Nis B. Høst, Finn M. Karlsen, Gunnar H. Gislason, Jesper Hastrup Svendsen, Hanne K. Christensen, Tor Biering-Sorensen
Journal: Journal of the American College of Cardiology (2019)
IDENTIFYING BIOMARKERS INDEPENDENTLY ASSOCIATED WITH SPONTANEOUS REPERFUSION IN ST ELEVATION MYOCARDIAL INFARCTION
Authors: Jay Shavadia, Christopher B. Granger, Wendimagegn Alemayehu, Cynthia Westerhout, Thomas Povsic, Sorin Brener, Christopher DeFilippi, Paul Armstrong
Journal: Journal of the American College of Cardiology (2019)
THE REASONS WHY FRACTIONAL FLOW RESERVE AND INSTANCE WAVE-FREE RATION ARE SIMILAR USING WAVE SEPARATION ANALYSIS
Authors: Joon Hyouk Choi, Justin Davies, Christopher Cook, Sayan Sen, Sukhjinder Nijjer, Ricardo Petraco Da Cunha, Rasha Al-Lamee, Yousif Ahmad
Journal: Journal of the American College of Cardiology (2019)
THE ASSOCIATION OF PERCEIVED STRESS WITH HEALTH STATUS OUTCOMES IN PATIENTS WITH PERIPHERAL ARTERY DISEASE
Authors: Ali O. Malik, Poghni Peri-Okonny, Jeremy Provance, Kensey Gosch, Merrill Thomas, Clementine Labrosciano, John A. Spertus, Kim Smolderen
Journal: Journal of the American College of Cardiology (2019)
GVHD Is Sustained By T Cell Maintenance within Target Tissues: Insights from Clonal Tracking and Parabiosis
Authors: Faruk Sacirbegovic, Sarah T Rosenberger, Daqiang Zhao, Matthias Günther, Martin H Oberbarnscheidt, Fadi G Lakkis, Thomas Höfer, Warren D Shlomchik
Journal: Blood (2018)
Integrated Adherence Monitoring for Inhaler Medications
Authors: Mark Hew, Helen K. Reddel
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HEPARIN AND LOW-MOLECULAR-WEIGHT HEPARIN SWITCH ASSOCIATED WITH AN INCREASE IN BLEEDING COMPLICATIONS IN PATIENTS ON APIXABAN UNDERGOING CATHETER ABLATION: THE AMPER ABLATION STUDY
Authors: Walid Amara, Rodrigue Garcia, Jacques Mansourati, Jerome Taieb, Estelle Gandjbackh, Antoine Dompnier, Herve Gorka, Noura Zannad-Bahe, Antoine Da Costa, Fred Sacher, Francois Jourda, Stephane Fromentin, Saida Cheggour, Frederic Georger, Arthur Ramonatxco, Antoine Milhem
Journal: Journal of the American College of Cardiology (2019)
Measures aim to promote SAS doctors as a “genuine alternative” to postgraduate training
Authors: Abi Rimmer
Journal: BMJ (2019)

Health Education England (HEE) has outlined a range of measures designed to better support specialty and associate specialist (SAS) doctors in the NHS.1

A foreword to the report says: “The actions from this guidance are aligned to the ambitions of the NHS Long Term Plan and aim to ensure that there is a visible career trajectory for SAS doctors that is a genuine alternative for those not wanting to pursue …
皮肤外科诊所中的 OTR 管理
Authors: K. Papier, L.G. Gordon, K. Khosrotehrani, N. Isbel, S. Campbell, A. Griffin, A.C. Green
Journal: British Journal of Dermatology (2019)

接受器官移植的患者由于长期接受免疫抑制治疗更可能发生皮肤癌。对于居住在澳大利亚昆士兰的器官移植受者 (OTR) 尤其如此,因为该地区的皮肤癌比别的地方更常见。为了尝试阐明居住在昆士兰 OTR 中的极端皮肤癌问题,在布里斯班建立了一个专门的移植皮肤诊所。这项研究旨在介绍澳大利亚昆士兰这一新诊所(同类中首个)的表现。邀请诊所就诊者们完成了两项调查,这两项调查间隔 3 个月提供,涉及他们的健康和个人特征,并获得了允许,可访问正在参与的就诊者的病历,以了解在相同的 3 个月时间段中发现和治疗的皮肤癌的细节。作者们共计招募了 101 名诊所患者进入此研究。在 3 个月时间中,作者们发现,在该诊所检出了 615 例皮损。其中 55 例被转诊至该诊所以外接受治疗,478 例在诊所内接受治疗,大部分(78%)通过手术。在该诊所内治疗的皮损中,268 例被确诊为皮肤癌,相当于 3 个月中每名患者接近 3 例皮肤癌。平均而言,在每 1.4 例他们成功手术切除的皮损中,该诊所就成功治疗了 1 例皮肤癌。总而言之,这项研究发现,该诊所检测并有效治疗了大量的 OTR 中的皮肤癌,因此有助于高效控制居住在昆士兰的 OTR 的癌症负担。
IMPACT OF RENAL FUNCTION IN PATIENTS WITH HIGH BLEEDING RISK WHO UNDERWENT PERCUTANEOUS CORONARY INTERVENTION WITH XIENCE: A PATIENT-LEVEL POOLED ANALYSIS FROM FOUR XIENCE POST-APPROVAL TRIALS
Authors: Toshiki Kuno, Paul Guedeney, Bimmer Claessen, Roxana Mehran, Marco Valgimigli
Journal: Journal of the American College of Cardiology (2019)
Letter to the Editor: Is Nodular Regenerative Hyperplasia an Immune‐Mediated Phenomenon?
Authors: Nedim Hadžić
Journal: Hepatology (2019)

Potential conflict of interest: Nothing to report. To the Editor: LoPiccolo et al.1 describe the very effective clinical management of severe portal hypertension associated with nodular regenerative hyperplasia (NRH), developing acutely during melanoma treatment with pembrolizumab. Pembrolizumab is a novel immunoglobulin G4 antibody targeting the antiprogrammed death‐1 receptor on lymphocytes, and therefore physiologically serving as an immune check‐point blocker. NRH is a rare diffuse architectural disturbance of the liver that is thought to be caused by uneven microperfusion, secondary to endothelial damage of the small portal vein radicles.2 It is likely that NRH is overall underdiagnosed due to its slow‐evolving nature, but in an unknown proportion of individuals it progresses to histological nodularity (<3 mm) with no fibrosis, clinically significant portal hypertension, and end‐stage liver disease.2 Due to the frequent association with immune‐mediated and hemato‐oncological conditions and/or use of medications interfering with the lymphocyte functions (e.g., azathioprine, 6‐thioguanine, busulfan, cyclophosphamide, oxaliplatin),2 it has been tempting to contemplate a putative immune background to NRH. A particularly strong association has been observed with common variable immune deficiency (CVI), noted in between 5%‐12% of all CVI patients.3 Most of the patients with NRH and CVI have autoimmune‐like manifestations, such as idiopathic thrombocytopenic purpura, scleroderma, psoriasis, vasculopathies, autoimmune hemolytic anemia, or arthritis.3 CVI has not been defined molecularly, but the principal immunological features involve B cell and T cell abnormalities with defective interleukin‐4 signaling, resulting in poor antibody production and frequent hypogammaglobulinemia.3 A possible explanation for the link was suggested when one‐third of NRH patients were found to have cytotoxic CD8+ T cells in hepatic sinusoids adjacent to atrophic areas. These CD8+ T cells specifically target apoptotic sinusoidal endothelial cells, according to clonality studies, and thus rule out the “passenger lymphocyte” effect.4 The similar CD8+ T cell infiltrate findings were reproduced with associated hepatic tissue increase in interferon‐γ production in NRH with CVI.3 Finally, one report described NRH in adult sibling pairs from three unrelated families with no triggering factors in history and severe clinical phenotypes.5 Although LoPiccolo et al.1 suggest the idiosyncratic nature of this rare complication in background of immune check blockade, we wonder whether patients with NRH should be subjected to formal immunological studies and the emerging large‐scale genetic sequencing studies involving subtler immunological aberrations. Although NRH is likely a heterogeneous condition, it is conceivable that a proportion could have a verifiable underlying immune dysregulation.
ADDITIONAL ROLE OF ECHOCARDIOGRAM IN PULMONARY ARTERIAL HYPERTENSION RISK STRATIFICATION ACCORDING TO CURRENT ESC/ERS GUIDELINES
Authors: Fabio Dardi, Alessandra Manes, Massimiliano Palazzini, Enrico Gotti, Andrea Rinaldi, Elisa Zuffa, Alessandra Albini, Daniele Guarino, Alessandro De Lorenzis, Filippo Pasca, Ilenia Magnani, Mariangela Rotunno, Nazzareno Galiè
Journal: Journal of the American College of Cardiology (2019)
FOCAL TAKOTSUBO CARDIOMYOPATHY: NAVIGATING THE DIFFERENTIALS WITH HELP OF CARDIAC MAGNETIC RESONANCE IMAGING
Authors: Rahul Vasudev, Rachel Abboud, Rushdy Abanoub, Sameh Scander, Rana Garris, Upamanyu Rampal, Nirmal Guragai, Hiten Patel, Priyank Shah, Fayez Shamoon, Hartaj Virk, Mahesh Bikkina
Journal: Journal of the American College of Cardiology (2019)
VALUE OF AORTIC PLAQUE IN PREDICTING LEFT ATRIAL APPENDAGE THROMBUS IN LOW RISK PATIENTS UNDERGOING ELECTROPHYSIOLOGICAL PROCEDURES
Authors: Samah Alkharji, Michelle Samuel, Mohamed Al Rawahi, George Thanassoulis, Martin L. Bernier, Thao Huynh, Vidal Essebag, Jacqueline Joza
Journal: Journal of the American College of Cardiology (2019)
DYSGLYCEMIA, EJECTION FRACTION, AND THE RISK OF HEART FAILURE OR CARDIOVASCULAR DEATH IN PATIENTS WITH TYPE 2 DIABETES AND A RECENT ACUTE CORONARY SYNDROME
Authors: Sung-Hee Shin, Brian Claggett, Marc Pfeffer, David Aguilar, Rafael Diaz, Kenneth Dickstein, Hertzel Gerstein, Lars Kober, Francesca Lawson, Eldrin Lewis, Aldo Maggioni, John McMurray, Jeffrey Probstfield, Matthew C. Riddle, Jean Claude Tardif, Scott Solomon
Journal: Journal of the American College of Cardiology (2019)
Better survival in female SOD1-mutant patients with ALS: a study of SOD1-related natural history
Authors: Lu Tang, Yan Ma, Xiao-lu Liu, Lu Chen, Dong-sheng Fan
Journal: Translational Neurodegeneration (2019)

SOD1 mutations are the most common cause of amyotrophic lateral sclerosis (ALS) in non-Caucasian patients. Detailed natural history profiles of SOD1-mutant patients will be beneficial for the strategy and interpretation of future SOD1-targeted clinical practice. Mutational distribution, age at onset (AAO), site of onset, diagnostic delay, disease progression (rate of ALSFRS-R decrease, ΔFS) and survival were analysed. Further comparisons between heredity of disease, gender, and mutations were performed. Sixty-six cases with 43 SOD1 mutations were included and analysed, with p.His47Arg as the leading mutation and seven novel variants identified. The mean (SD) AAO was 43.92 years (9.24) for all subjects, with a significant difference between patients carrying mutations in exon 2 (n = 24,46.83, 8.31) and exon 4 (n = 18, 37.75, 7.67) (p = 0.002). The median (IQR) diagnostic delay from symptom onset was 14.50 (6.00–36.50) months for all SOD1-mutant patients, 9.50 (4.75–24.25) months for males and 24.00 (9.50–47.50) months for females, revealing a gender difference (p = 0.009). Similar advantages in median (IQR) ΔFS [male: female, 0.55 (0.24–0.94) vs 0.19 (0.06–0.90), p = 0.041] and mean (95% CI) survival [57.4 (38.90–75.90) months vs 125.6 (99.80–151.50) months, p = 0.006] were also observed in females, both of which existed in sporadic ALS only when stratified by familiar or sporadic ALS. The results highlight a distinct mutational distribution and natural history spectrum in ALS patients carrying SOD1 mutations in China. A prominent mild disease progression was observed in female patients, which had rarely been reported in the previous literature. This finding, together with the detailed analysis of natural history among each mutation, can have important implications for future genetic counselling and SOD1-targeted clinical trials.
Abstract 15948: Inhibition of NF-kB Signaling Attenuates Age-related Aggravation of Myocardial Ischemia/Reperfusion Injury
Authors: Guangming Cheng, Sheng Ye, Magdy Girgis, Lin Zhao, Xing Chen, Anweshan Samanta, Yanjuan Yang, Jeryl Hauptman, Robert Vincent, Buddhadeb Dawn
Journal: Circulation (2015)

Introduction: Emerging evidence indicates that myocardial ischemia/reperfusion (I/R) injury is more severe in aged hearts. Although nuclear factor-kappaB (NF-kB) activity increases with aging, whether this redox-responsive transcription factor plays any role in age-related worsening of I/R injury remains unknown. Hypothesis: We hypothesized that activation of myocardial NF-kB exerts deleterious effects during I/R injury in young as well as aged hearts; and that NF-kB signaling contributes to age-related worsening of myocardial I/R injury. Methods: We used transgenic mice overexpressing a mutant IkBa that prevents NF-kB activation only in the heart. Age-matched young (10-week-old) and aged (86-week-old) male non-transgenic littermates (NTg) and IkBa transgenic (Tg) mice underwent a 30-min coronary occlusion followed by 24 h of reperfusion. Following sacrifice, infarct size was measured and molecular assays were performed. Results: The infarct size was significantly smaller in young Tg mice compared with young NTg mice (Fig), indicating a deleterious role of NF-kB signaling during myocardial I/R injury even in the young. The infarct size in aged NTg hearts was greater compared with young NTg hearts, consistent with an age-related worsening of I/R injury effects. However, infarct size in aged Tg hearts was significantly smaller than aged NTg hearts, and similar to young Tg hearts, indicating that NF-kB signaling contributes toward age-related aggravation of I/R injury. Interestingly, the levels of molecular markers of senescence, such as p16, were lower in aged Tg hearts (Fig), indicating a deleterious role of NF-kB in cardiac aging and susceptibility to I/R injury. Conclusions: We conclude that inhibition of cardiac NF-kB signaling protects against age-related aggravation of acute myocardial I/R injury. These findings suggest that modulation of NF-kB signaling may be potentially used to achieve therapeutic cardioprotection in the elderly.
Pre-Chemotherapy Levels of Hemostatic Biomarkers and Prediction of Prognosis in Newly Diagnosed Metastatic Cancer Patients from the Hypercan Study
Authors: Anna Falanga, Cinzia Giaccherini, Cristina Verzeroli, Marina Marchetti, Laura Russo, Giovanna Masci, Luigi Celio, Barbara Merelli, Roberta Sarmiento, Mara Ghilardi, Carmen J Tartari, Shenaz Brevi, Gloria Caldara, Sara Gamba, Paolo Malighetti, Daniele Spinelli, Armando Santoro, Filippo De Braud, Giampietro Gasparini, Francesco Giuliani, Sandro Barni, Andrea D'Alessio, Roberto Labianca
Journal: Blood (2018)
Pairing JAK with MEK for improved therapeutic efficiency in myeloproliferative disorders
Authors: David A. Williams
Journal: Journal of Clinical Investigation (2019)

The identification of JAK2 mutations as disease-initiating in myeloproliferative neoplasms (MPNs) has led to new and effective therapies for these diseases. In a study published in this issue of the JCI, Stivala et al. explored the key observation that JAK inhibition successfully suppresses MAPK activation in MPN cell lines and primary MPN cells in vitro, and the finding that it failed to completely and effectively suppress MAPK activation in vivo in two mouse models. The authors went on to show that dual inhibition of JAK and the MAP kinase pathway provided enhanced therapeutic efficacy in the in vivo models of MPN.
ACCURACY OF COMBINED PARAMETERS OF SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY MYOCARDIAL PERFUSION IMAGING IN MULTI VESSEL CORONARY ARTERY DISEASE PATIENTS ASSESSED WITH FRACTIONAL FLOW RESERVE
Authors: Lucas Cronemberger Maia Mendes, Mateus V. Silva, Maria Letícia B.R. Ambiel, Edmur C. Araújo, Sebastião L. Lacerda Filho, Heleno R. Reis, Carlos J.D.G. Barbosa
Journal: Journal of the American College of Cardiology (2019)