tbuckley/cabot-search huggingface dataset:
Mental health and its related factors in patients with cardiac rehabilitation after coronary artery bypass grafting
Authors: Min Liu, Bo Yu, Qian Song, Zhi Fu, Chengbo Sun
Journal: BMJ (2019)

The mental health status of 237 patients with coronary heart disease who participated in cardiac rehabilitation (CR) after coronary artery bypass grafting and 148 non-participating patients(control group) in three hospitals was evaluated, and the related factors for mental health of patients with CR were analyzed. The results showed that the anxiety,depression,and quality of life scores of patients after 2 months of participation in CR were significantly lower than those before CR (P<0.05),and the incidence of anxiety and depressive symptoms was significantly lower than that in control group (18.5% vs. 31.1% and 14.8 vs. 25.0%, respectively, P<0.05). The risk of anxiety and depressive symptoms was higher in CR participants with lower monthly income [OR=0.335(0.150-0.751),P=0.008],unemployment [OR=0.427(0.244-0.749),P=0.003] and knowing their own disease [OR=3.243(1.427-7.371), P=0.005]. This study shows that CR can effectively improve the state of depression and anxiety and improve the quality of life. The implementation of CR shoμld fully consider a variety of influencing factors and develop a targeted rehabilitation program.


Key words: 
Cardiac rehabilitation; Coronary artery bypass grafting; Mental health
18F-FDG PET/CT Imaging of Adrenal Liposarcoma
Authors: Rang Wang, Qiuping Fan, Rong Tian
Journal: Clinical Nuclear Medicine (2020)

Liposarcoma is a common soft tissue sarcoma in retroperitoneum, but adrenal liposarcoma is rare. We here described a 61-year-old man with left-upper-quadrant pain, hypertension, and weight loss. Abdominal CT showed a large, heterogeneously enhanced mass on the left adrenal area, which compressed the surrounding pancreas, spleen, and left kidney. Subsequent FDG PET/CT demonstrated heterogeneous uptake by the lesion. Postoperative pathological findings confirmed the diagnosis of adrenal liposarcoma.
Mimicking the radiologists’ workflow: Estimating pediatric hand bone age with stacked deep neural networks
Authors: Sven Koitka, Moon S. Kim, Ming Qu, Asja Fischer, Christoph M. Friedrich, Felix Nensa
Journal: Medical Image Analysis (2020)

Pediatric endocrinologists regularly order radiographs of the left hand to estimate the degree of bone maturation in order to assess their patients for advanced or delayed growth, physical development, and to monitor consecutive therapeutic measures. The reading of such images is a labor-intensive task that requires a lot of experience and is normally performed by highly trained experts like pediatric radiologists. In this paper we build an automated system for pediatric bone age estimation that mimics and accelerates the workflow of the radiologist without breaking it. The complete system is based on two neural network based models: on the one hand a detector network, which identifies the ossification areas, on the other hand gender and region specific regression networks, which estimate the bone age from the detected areas. With a small annotated dataset an ossification area detection network can be trained, which is stable enough to work as part of a multi-stage approach. Furthermore, our system achieves competitive results on the RSNA Pediatric Bone Age Challenge test set with an average error of 4.56 months. In contrast to other approaches, especially purely encoder-based architectures, our two-stage approach provides self-explanatory results. By detecting and evaluating the individual ossification areas, thus simulating the workflow of the Tanner–Whitehouse procedure, the results are interpretable for a radiologist.
The effect of under and uninsured status on survival in lung cancer while adjusting for other mortality risk factors.
Authors: Mohamed K. Mohamed, Dana Herndon, Monica Schmidt, Matthew A. Manning
Journal: Journal of Clinical Oncology (2020)

e21734 Background: Lung cancer is the leading cause of cancer death in the US. Significant improvements in survival have occurred with improved treatments. Payer status has been recognized as a barrier to treatment access across multiple cancer types including lung. This study aims to evaluate the impact of payer on 2-year survival rates for patients presenting in one health system with newly diagnosed lung or bronchus cancer. Methods: This is a retrospective survival analysis. There were 1,681 patients with lung cancer (small and non-small) under observation from time of first diagnosis. The first diagnosis date in the Cone health system defined study entry. Failure was defined as death during the 2-year observation period with right censoring after 2-years. Patients were categorized as underinsured if they had no insurance or Medicaid while those with commercial and Medicare were considered having full coverage. Cox proportional hazard models were used reporting hazard ratios. Results: Mortality rates per 10 patients diagnosed with lung or bronchus cancers were 3.5 for those with commercial insurance, 3.8 for Medicare, 3.3 for Medicaid and 5.4 for uninsured patients. Of those patients considered underinsured, 56.7% presented with stage IV cancer compared to those with full coverage (41.4%)*. 40.7% of those without insurance or underinsured were current tobacco product users compared to 25.1% of those with full coverage. Cox proportional hazard models revealed the risk of death is 1.34* times (95% CI 1.07-1.68) greater for underinsured patients compared to those with full coverage. The model adjusted for age, race, gender, marital status, language, Gini coefficient, Elixhauser comorbidity index, illicit drug use, cigarette smoker, smokeless tobacco user, alcohol use, PCP on record, and religion. However, when we add the AJCC stage to this model, the underinsured estimate is no longer statistically significant (1.23; 95% CI 0.92-1.65). Conclusions: Patients without insurance are diagnosed at later stages of disease. This late diagnosis is the primary driver of poor survival. Although being underinsured or uninsured is associated with a greater risk of death after diagnosis, adjusting for stage mitigates this effect. These findings support the need for equal access to early screening and diagnosis regardless of payer. *statistically significant at p &lt; 0.05.
The landscape of DNA damage response (DDR) pathway in colorectal cancer (CRC).
Authors: Hiroyuki Arai, Andrew Elliott, Jingyuan Wang, Francesca Battaglin, Shivani Soni, Wu Zhang, Davendra Sohal, Richard M. Goldberg, Michael J. Hall, Aaron James Scott, Mohd Khushman, Jimmy J. Hwang, Emil Lou, Benjamin A. Weinberg, John Marshall, Albert Craig Lockhart, Phillip Stafford, Jian Zhang, W. Michael Korn, Heinz-Josef Lenz
Journal: Journal of Clinical Oncology (2020)

4064 Background: Abnormal DDR is a hallmark of cancer, relating to genome instability, anti-tumor immunity, and sensitivity to chemotherapeutic agents and radiation. We conducted a large-scale investigation to clarify the alteration of DDR pathway in CRC. Methods: Tumor samples from 9321 CRC patients were retrospectively reviewed. Next-Generation Sequencing (NGS) on a custom-designed panel enriching 592 gene targets was performed. Samples with mutations detected in any of 29 DDR-related genes were deemed DDR-mutant (DDR-MT); the rest DDR-wild type (DDR-WT). Microsatellite instability (MSI) status was tested with a combination of immunohistochemistry (IHC), fragment analysis and NGS. Tumor mutational burden (TMB) was calculated based on somatic nonsynonymous missense mutations. PD-L1 was tested by IHC (SP142). Consensus molecular subtype (CMS) was developed using RNA sequencing data. Results: Of 9321 cases, 1290 (13.8%) were DDR-MT. DDR-MT frequency was higher in right vs. left sided (20.9% vs 10.8%, p &lt; 0.001) and MSI-H vs. MSS (76.4% vs 9.5%, p &lt; 0.001) cases. In the MSS cases, right-sided had marginally higher frequency of DDR-MT than left-sided (10.6% vs 9.1%, p = 0.055), with much higher frequency of Fanconi anemia pathway alteration in right-sided (1.5% vs 0.7%, p &lt; 0.01). CMS1 subtype had the highest frequency of DDR-MT (34.8%); CMS2 had the lowest (7.1%). DDR-MT cases (vs. DDR-WT) had higher mutation rate of ARID1A (55.0% vs 19.1%, p &lt; 0.0001), PIK3CA (22.6% vs 15.8%, p &lt; 0.0001) and BRAF (20.4% vs 7.3%, p &lt; 0.0001), and lower mutation rate of TP53 (48.2% vs 76.1%, p &lt; 0.0001), APC (60.5% vs 74.5%, p &lt; 0.0001) and KRAS (44.0% vs 49.8%, p &lt; 0.001). Mean TMB was much greater in DDR-MT than DDR-WT (All: 20.9/Mb vs 7.7/Mb, p &lt; 0.0001; MSS: 13.7/Mb vs 7.6/Mb, p &lt; 0.05). PD-L1 positivity was also higher in DDR-MT compared to DDR-WT (All: 10.1% vs 2.7%, p &lt; 0.0001; MSS: 4.8% vs 2.4%, p &lt; 0.0001). Conclusions: Alteration of the DDR pathway was strongly associated with MSI status in CRC. The primary tumor sidedness might also be related, as DDR-MT was more prevalent in right-sided tumors. Elevated TMB and PD-L1 expression in DDR-MT CRC indicate more activated anti-tumor immune profiles compared to DDR-WT, regardless of MSI status, suggesting possible therapeutic benefit from immune checkpoint inhibitors in DDR-MT CRC.
Copy number variation and expression of CT-genes in patients with colorectal cancer.
Authors: Yuriy A. Gevorkyan, Denis S. Kutilin, Oleg I. Kit, Natalya V. Soldatkina, Dmitry A. Kharagezov, Andrey V. Dashkov, Dmitry O. Kaymakchi, Sergey I. Poluektov, Vladimir E. Kolesnikov, Vladimir A. Dontsov, Roman E. Tolmakh, Sergei A. Ilchenko, Oleg N. Stateshny, Dmitry S. Petrov, Fedor N. Grechkin, Nairi B. Oganyan, Ellada Mirzoyan, Yuriy A. Fomenko
Journal: Journal of Clinical Oncology (2020)

e16104 Background: Cancer-testis antigens (CTAs) can be used for immunotherapeutic approaches and early detection of malignant tumors. Despite numerous studies of CTA expression in various tumors, including colon tumors, the mechanisms of transcriptional activity regulation in colorectal cancer (CRC) remain poorly studied. One of the possible mechanisms of regulation of gene expression is a change in their copy number (CNV). The aim of the study was to analyze the changes in the copy number and expression of CT-genes in patients with CRC. Methods: Tumor and normal colon tissues of 81 patients were used in the study. DNA was isolated by phenol-chloroform extraction. RNA was isolated by the Chomczynski&amp;Sacchi method (2006). The REVERTA-L reagent kit was used for the cDNA synthesis. Determination of expression and copy number of 16 CT genes ( MAGE-A1, -A2, -A3, -A4, MAGE-B1, -B2, GAGE-1, -3, -4, MAGEC1, BAGE, XAGE3, NYESO1, SSX2, SCP1, PRAME1) was performed using the Real-Time qPCR method (reference genes - GAPDH and GUSB). Differences were evaluated using the Mann-Whitney test, correlation analysis - using Spearman's rank correlation coefficient (r). Results: An analysis of CT-gene expression and CNV in tumor and normal colon tissues (n = 81) revealed a statistically significant (p &lt; 0.05) difference between these parameters in tumor tissue relative to normal one: for MAGEB1 an increase of 2.0 and 2.7 times, GAGE3 an increase of 2.0 and 2.5 times, GAGE4 decreased by 5.0 and 6.8 times, BAGE decreased by 2.4 and 1.7 times, SSX2 increased by 1.8 and 2.1 times, SCP1 increased copy number by 4.4 times and PRAME1 increased expression and copy number by 2.9 and 2.3 times, respectively. When comparing CNV and expression of 16 CT genes, a positive correlation was observed (r = 0.875). Conclusions: Thus, the aberrant expression of MAGEB1, GAGE3, GAGE4, BAGE, SSX2 and PRAME1 found in the tumor tissue of CRC patients depends on the copy number of these CT-genes.
Fovea-like Photoreceptor Specializations Underlie Single UV Cone Driven Prey-Capture Behavior in Zebrafish
Authors: Takeshi Yoshimatsu, Cornelius Schröder, Noora E. Nevala, Philipp Berens, Tom Baden
Journal: Neuron (2020)

In the eye, the function of same-type photoreceptors must be regionally adjusted to process a highly asymmetrical natural visual world. Here, we show that UV cones in the larval zebrafish area temporalis are specifically tuned for UV-bright prey capture in their upper frontal visual field, which may use the signal from a single cone at a time. For this, UV-photon detection probability is regionally boosted more than 10-fold. Next, in vivo two-photon imaging, transcriptomics, and computational modeling reveal that these cones use an elevated baseline of synaptic calcium to facilitate the encoding of bright objects, which in turn results from expressional tuning of phototransduction genes. Moreover, the light-driven synaptic calcium signal is regionally slowed by interactions with horizontal cells and later accentuated at the level of glutamate release driving retinal networks. These regional differences tally with variations between peripheral and foveal cones in primates and hint at a common mechanistic origin.
Novel dose escalation to predict treatment with hydroxyurea ( <scp>NDEPTH</scp> ): A randomized controlled trial of a dose‐prediction equation to determine maximum tolerated dose of hydroxyurea in pediatric sickle cell disease
Authors: Alex George, Bogdan Dinu, Norma Estrada, Charles G. Minard, Richard Hurwitz, Donald H. Mahoney, Amber M. Yates, Mary Vaughan, Alaundra Carmouche, Gladstone Airewele, Susan E. Kirk, Titilope Fasipe, Precious Uwaezuoke, Russell E. Ware
Journal: American Journal of Hematology (2020)
发挥全科医学分会在全科医生制度建设中的作用
Authors: 张愈, 顾湲
Journal: BMJ (2011)

在中国医疗卫生体制改革(医改)的关键时刻、在我国医药卫生事业和群众健康事业发展的重要关头,国务院正式颁布文件在中国推行全科医生制度,将全科医生制度提到国家战略的高度.这是具有历史性和革命性的事件,是新医改保基本、强基层、建机制的最有力体现,它将对我国医师队伍的结构和医疗服务模式产生巨大的影响.在这样的背景下,我们相聚在古城西安,满怀着激情和责任,共同谋划“全科医学”这样一个伟大事业,感到非常激动和自豪.在此,首先对中华医学会全科医学分会的建立和发展做一个大概回顾。
Interpretation of Rome IV criteria for functional dyspepsia
Authors: Xiaohong Sun
Journal: BMJ (2017)

与罗马Ⅲ分类及诊断标准相比较，罗马Ⅳ对功能性消化不良(FD)总体上调整不多。FD诊断标准时限仍定为病程超过6个月，近3个月有症状发作，餐后饱胀、早饱、上腹痛、上腹部烧灼感4个核心症状的程度影响日常生活，根据症状与进餐关系，FD人分为餐后不适综合征和上腹痛综合征两个亚型。临床上推荐胃镜检查，但不常规推荐胃功能评估。调节生活方式是治疗FD的基础；根据FD亚型可经验性选择抑酸药物治疗或促动力剂治疗；根除Hp治疗可使患者长期获益；对于难治性FD患者推荐抗焦虑抑郁药物治疗。
Anticoagulation management by physician-clinical pharmacist team for patients with valvular atrial fibrillation
Authors: Wenqi Liu, Jie Liu, Zhengrong Li, Fengyuan Che, Zonglin Zhang, Zengcheng Shi, Zhihong Ou
Journal: BMJ (2018)

Objective
To evaluate the effectiveness of anticoagulation management by physician-clinical pharmacist team for patients with valvular atrial fibrillation.


Methods
One hundred and seventy two patients with valvular atrial fibrillation received warfarin therapy for anticoagulation during hospitalization in Linyi People′s Hospital from January 2014 to December 2016, the patients continued to receive warfarin therapy for>6 months after discharge. The patients were randomly assigned in two groups: the anticoagulation management was given by physician-clinical pharmacist team in 87 cases (trial group), while the dosage of wargarin was adjusted in outpatient department by physicians alone in 85 cases (control group). The goal attainment rate of international normalized ratio (INR), the proportion of patients with a stable warfarin dose, knowledge of anticoagulants, belief of medication, medication compliance were compared between two groups.


Results
There were no significant differences in age, sex, body weight, smoking and drinking habits, valvular disease type, comorbidities; and the initial INR, knowledge of anticoagulants, belief of medication and medication compliance at admission between two groups (all P>0.05). The goal attainment rate of INR (52.17% vs. 41.02%, χ2=8.178,P=0.004), the proportion of patients with a stable dose of warfarin (74.71% vs. 56.47%, χ2=6.349, P=0.012), the knowledge of anticoagulants(11.03±2.25 vs. 10.08±1.86, t=3.018, P=0.003), the belief of medication[(12.23±2.07) vs.(11.67±1.48), t=2.042, P=0.043], and the medication compliance[(7.36±0.89) vs. (7.04±1.10), t=2.112 8, P=0.036] in the trial group were significantly higher than those in control group.


Conclusion
Anticoagulation management by physician-clinical pharmacist team can improve the management level of anticoagulation and the knowledge of anticoagulans, enhance the medication belief, improve the goal attainment rate of INR and the compliance rate of medication in patients with valvular atrial fibrillation.


Key words: 
Atrial fibrillation; Warfarin; Anticoagulation management service; Physician; Clinical pharmacist; International normalized ratio
Clinical significance of small airway function and inflammatory markers in induced sputum among patients with clinically controlled asthma
Authors: Han-xiang Nie, Xu-hong Ding, Yi Huang, Su-ping Hu
Journal: BMJ (2010)

Objective To investigate clinical significance of small airway function and eosinophil (Eos) percentage,levels of eosinophil cationic protein (ECP) and IL-5 in induced sputum among patients with clinically controlled asthma. Methods Sixty-two patients with clinically controlled asthma were selected for the study. Lung function was performed and percentage of Eos, levels of ECP and IL-5 in induced sputum were measured by Wrights' stain, fluorescence immuno-CAP system and ELISA,respectively. Thirty patients of asthma at acute exacerbation period and 20 healthy subjects were selected as controls. Results In 62 patients with clinically controlled asthma, 43 (69. 4% ) showed abnormal small airway function and 19(30. 6% ) normal one. Percentage of Eos [(5. 6 ±2. 9)%], levels of ECP [( 129 ±100) μg/L] and IL-5 [(21± 12) μg/L] in induced sputum were significantly lower in patients with clinically controlled asthma than those of asthma at acute exacerbation period [( 16. 2 ± 9. 7 ) %, ( 362 ±182) μg/L and IL-5(51 ±26) μg/L, respectively] (all P ＜0. 01 ), but significantly higher than those in healthy controls ( all P ＜ 0. 01 ). Percentage of Eos, levels of ECP and IL-5 in induced sputum were significantly higher in patients with clinically controlled asthma with abnormal small airway function than those with normal ane [(6.9±3.1)% vs. (2.0±1.1)%, (148±90) μg/Lvs. (54±29) μg/L and (24 ±12) μg/L vs. ( 13 ± 5 ) μg/L, respectively] ( all P ＜ 0. 01 ). Conclusions Abnormal small airway function and airway inflammation persistently exist in patients with clinically controlled asthma and it may be helpful to guild treatment during clinical control to determine small airway function and inflammatory markers in their induced sputum.

Key words: 
Asthma; Eosinophils; Eosinophil cationic protein
乳胶手套致接触性皮炎一例
Authors: 姜文忠, 杨学敏, 李淑华
Journal: BMJ (2005)

患者男,35岁,外科医生,从事外科工作11年.因手术后手臂出现皮疹伴瘙痒就诊.近4年来双手经常于手术后起皮疹,粟粒状,以手背部为多,有时蔓延至腕部,春夏较重,涂擦氟西奈德(肤轻松)软膏后,皮疹好转或消失,未予重视.近半年来手术后又起皮疹,且皮疹渐重,愈期延长,遂采用薄线手套作内衬,仍不能阻止其发作.既往无药物过敏史及家族史.皮肤检查:双手背皮肤轻度发红,可见散在粟粒大小红色丘疹,余无异常.致敏原检查:采用瑞典生产标准抗原系列(瑞典化学诊断AB公司),患者皮损消退后,进行常规斑贴试验,按ICDRG标准判定[1].结果显示,秋蓝姆混合物呈强阳性,用秋蓝姆混和物的成分作斑贴试验,发现硫化物四甲基秋蓝姆(TETD)、二硫化物四甲基秋蓝姆(TMTD)均为强阳性,二硫化双亚戊基秋蓝姆(PTD)为阴性。
Logistic regression analysis for risk factors related to end-stage liver disease among HIV/HBV co-infection patients
Authors: Rong-rong Yang, Xi-en Gui, Shi-cheng Gao, Yong Xiong, Li-ping Deng, Yu-ping Rong
Journal: BMJ (2011)

Objective To understand major risk factors associated with end-stage liver disease (ESLD) among patients with human immunedeficiency virus (HIV)/hepatitis B virus (HBV) co-infection.Methods Patients with HIV/HBV co-infection were followed-up and factors related to ESLD were analyzed using logistic regression model to estimate odds ratios (ORs) for them. Results A total of 255 patients with HIV/HBV co-infection were investigated, with an incidence of ESLD of 19. 2% ( 49/255 ). Major risk factors associated with ESLD among patients with HIV/HBV co-infection included count of CD4 below 200 cells/μl at baseline, HIV RNA load decreasing to the lower limit of its detection level within six months after antiretroviral treatment (ART), abnormal of serum activities of transaminase (ALT or AST), longer persistently positive of HIV RNA and HBV DNA, and use of lamivudine-based ART, with OR of 6. 503,14. 456, 0. 049, 1. 814, 1. 536 and 0. 012, respectively. Conclusions Lower CD4 count, abnormal serum transaminases, persistent replication of HIV and HBV all are closely related to ESLD in patients with HIV/HBV co-infection. Therefore, lamivudine-based ART should be of choice for patients with HIV/HBV coinfection to decrease incidence of ESLD.

Key words: 
Human immunodeficiency virus;  Hepatitis B virus;  End-stage liver disease
深静脉置管应用体会
Authors: 李泓, 王超, 李纯, 郭晓青
Journal: BMJ (2011)

深静脉置管是危重症抢救中可靠、有效的抢救措施之一,包括:锁骨下静脉穿刺,颈内静脉穿刺,股静脉穿刺三种方式.2008年10月至2010年12月,本院对100例患者实施了深静脉穿刺置管,效果较好。
アドレノメデュリンによる麻酔モルモットにおけるヒスタミン・チャレンジに対する血管作用性と小腸ペプチド、イソプレナリンとテオフィリンの気管支保護効果の相乗作用 | 文献情報 | J-GLOBAL 科学技術総合リンクセンター
Authors: Kanazawa H, Kawaguchi T, Fujii T, Shoji S, Hirata K, Kudoh S, Kurihara N, Yoshikawa J
Journal: Thorax (1996)
Atrial fibrillation in the elderly: a risk factor beyond stroke
Authors: Leonardo Bencivenga, Klara Komici, Pierangela Nocella, Fabrizio Vincenzo Grieco, Angela Spezzano, Brunella Puzone, Alessandro Cannavo, Antonio Cittadini, Graziamaria Corbi, Nicola Ferrara, Giuseppe Rengo
Journal: Ageing Research Reviews (2020)
Interventions for falls of the elderly in general practice
Authors: Yue Jiang
Journal: BMJ (2016)

老年人跌倒发生率高，且随年龄的增加急剧上升，后果严重，是高龄老年人首位伤害死因，给个人、家庭以及社会带来巨大负担，需要积极做好防控工作。我们在《老年人跌倒干预技术指南》的基础上，结合国内外相关研究成果和社区实际情况，制定了老年人跌倒干预流程图，可从个人、家庭和社区3个不同层面来实施，并提出老年人跌倒的全科医学干预措施。
Expression profile of micro-RNA of lymphovascular invasive colon cancer.
Authors: Zhongning Chen, Tyler Fugere, Yadav Pandey
Journal: Journal of Clinical Oncology (2020)

e16109 Background: Lymphovascular invasion (LVI) is an independent predictor of disease progression in patients with colorectal cancer, and is often associated with high tumor grade and advanced tumor stage. In concordance, micro-RNA(miRNA), which are small non-coding RNA that regulate post-transcriptional gene expression, have also recently been shown to be promising biomarkers to predict disease prognosis. The purpose of this study is to investigate [1] potential mechanism of tumor invasion by identifying miRNA that are differentially expressed with respect to LVI status, and [2] create a model to predict likelihood of SVI. Methods: Data was obtained from the TCGA database. Patients were selected based on biopsy proven diagnosis of adenocarcinoma of the colon. Patients were divided into based on the status of lymphovascular invasion (209 patients LVI negative, and 145 patients positive). A total of 130 miRNA were analyzed after filtering out miRNA expression counts &lt; 10. The differential expression profile of the miRNA between the two groups were analyzed using a quasi-likelihood F test implemented by bioconductor package, edgeR. This package is well documented for analyzing RNA-seq data due to adjustment for biological variations and measuring error using a negative binomial distribution. After adjusting for gender, the expression of miRNA |Log2FC| &gt; .3 and P value &lt; 0.05 were obtained. A model was created using support vector machine (SVM) using miRNA that are differentially expressed. Results: Compared to negative LVI group, the positive LVI group has a miRNA profile with the down regulation of hsa-let-7f-1, hsa-let-7f-2, hsa-mir-200c, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-378a, hsa-mir-374a, hsa-mir-361, hsa-mir-128-1, and hsa-mir-200b, and up regulation of hsa-mir-142, hsa-mir-199b, hsa-mir-199a-1, and hsa-mir-199a-2. A support vector machine classifier with a predict power of 70% was created using the miRNA described as above. Conclusions: This miRNA expression profile unifies known pathways for LVI, such as over expression of myosin heavy chain 9 gene, or dysregulation of zinc finger E-box binding homeobox 1. They also act as biomarkers to predict the likelihood of LVI.