tbuckley/cabot-search huggingface dataset:
Endocrinopathies Following Allogeneic Stem Cell Transplantation: 10 Years Follow-up in 402 Patients
Authors: Maria Teresa Lupo Stanghellini, Giovanni Vita, Andrea Assanelli, Francesca Lorentino, Fabio Serpenti, Raffaella Greco, Magda Marcatti, Fabio Giglio, Elisabetta Xue, Gabriele Casirati, Francesca Farina, Daniela Clerici, Sara Mastaglio, Carmine Liberatore, Lorenzo Lazzari, Simona Piemontese, Francesca Pavesi, Massimo Bernardi, Jacopo Peccatori, Consuelo Corti, Chiara Bonini, Fabio Ciceri, Emanuele Bosi
Journal: Blood (2018)
STIFF AND STRONG: DOES RESTRICTIVE RIGHT VENTRICULAR PHYSIOLOGY PROTECT RIGHT VENTRICULAR FUNCTION IN ADULTS WITH REPAIRED TETRALOGY OF FALLOT AND PULMONARY REGURGITATION?
Authors: Sarah Blissett, Ahmed Kheiwa, Kelly Cordero, Anushree Agarwal, Elyse Foster, Ian Harris, Vaikom Mahadevan, Karen Ordovas
Journal: Journal of the American College of Cardiology (2019)
A NOVEL RISK MODEL FOR VERY LATE RETURN OF ATRIAL FIBRILLATION AFTER CRYOBALLOON ABLATION: THE SCALE-CRYOAF SCORE
Authors: Graham Peigh, Rachel Kaplan, Aakash Bavishi, Celso Diaz, Richard Matiasz, Amar Trivedi, Prasongchai Sattayaprasert, Jeremiah Wasserlauf, Mark Shen, Alexandru Chicos, Rishi Arora, Susan Kim, Albert Lin, Nishant Verma, Bradley Knight, Rod Passman
Journal: Journal of the American College of Cardiology (2019)
TISSUE-BASED MARKERS OF RIGHT VENTRICULAR DYSFUNCTION IN ISCHEMIC MITRAL REGURGITATION AS ASSESSED VIA STRESS CARDIAC MAGNETIC RESONANCE
Authors: Jonathan Kochav, Brian Yum, Nathan Tehrani, Lillian Brouwer, Richard Devereux, Jonathan Weinsaft, Jiwon Kim
Journal: Journal of the American College of Cardiology (2019)
Blast Fungal Genomes Show Frequent Chromosomal Changes, Gene Gains and Losses, and Effector Gene Turnover
Authors: Luis B Gómez Luciano, Isheng Jason Tsai, Izumi Chuma, Yukio Tosa, Yi-Hua Chen, Jeng-Yi Li, Meng-Yun Li, Mei-Yeh Jade Lu, Hitoshi Nakayashiki, Wen-Hsiung Li
Journal: Molecular Biology and Evolution (2019)

Pyricularia is a fungal genus comprising several pathogenic species causing the blast disease in monocots. Pyricularia oryzae, the best-known species, infects rice, wheat, finger millet, and other crops. As past comparative and population genomics studies mainly focused on isolates of P. oryzae, the genomes of the other Pyricularia species have not been well explored. In this study, we obtained a chromosomal-level genome assembly of the finger millet isolate P. oryzae MZ5-1-6 and also highly contiguous assemblies of Pyricularia sp. LS, P. grisea, and P. pennisetigena. The differences in the genomic content of repetitive DNA sequences could largely explain the variation in genome size among these new genomes. Moreover, we found extensive gene gains and losses and structural changes among Pyricularia genomes, including a large interchromosomal translocation. We searched for homologs of known blast effectors across fungal taxa and found that most avirulence effectors are specific to Pyricularia, whereas many other effectors share homologs with distant fungal taxa. In particular, we discovered a novel effector family with metalloprotease activity, distinct from the well-known AVR-Pita family. We predicted 751 gene families containing putative effectors in 7 Pyricularia genomes and found that 60 of them showed differential expression in the P. oryzae MZ5-1-6 transcriptomes obtained under experimental conditions mimicking the pathogen infection process. In summary, this study increased our understanding of the structural, functional, and evolutionary genomics of the blast pathogen and identified new potential effector genes, providing useful data for developing crops with durable resistance.
PROGNOSTIC ROLE OF LEFT ATRIAL DYSFUNCTION AND ESTIMATION OF LEFT VENTRICULAR FILLING PRESSURE ON HEART FAILURE AND CARDIOVASCULAR DEATH IN NON VALVULAR ATRIAL FIBRILLATION: THE ENGAGE-AF TIMI ECHOCARDIOGRAPHIC SUB-STUDY
Authors: Riccardo M. Inciardi, Robert Giugliano, Brian Claggett, Christian Ruff, Deepak Gupta, Elliott Antman, Michele Mercuri, Michael Grosso, Howard Rutman, Eugene Braunwald, Scott Solomon
Journal: Journal of the American College of Cardiology (2019)
Identification of an antigenic determinant of clavulanic acid responsible for IgE‐mediated reactions
Authors: Nekane Barbero, Rubén Fernández‐Santamaría, Cristobalina Mayorga, Ángela Martin‐Serrano, María Salas, Gador Bogas, Francisco Nájera, Dolores Pérez‐Sala, Ezequiel Pérez‐Inestrosa, Tahia D. Fernandez, María I. Montañez, María J. Torres
Journal: Allergy (2019)

Selective reactions to clavulanic acid (CLV) account for around 30% of immediate reactions after administration of amoxicillin-CLV. Currently, no immunoassay is available for detecting specific IgE to CLV, and its specific recognition in patients with immediate reactions has only been demonstrated by basophil activation testing, however with suboptimal sensitivity. The lack of knowledge regarding the structure of the drug that remains bound to proteins (antigenic determinant) is hampering the development of in vitro diagnostics. We aimed to identify the antigenic determinants of CLV as well as to evaluate their specific IgE recognition and potential role for diagnosis.Based on complex CLV degradation mechanisms, we hypothesized the formation of two antigenic determinants for CLV, AD-I (N-protein, 3-oxopropanamide) and AD-II (N-protein, 3-aminopropanamide), and designed different synthetic analogs to each one. IgE recognition of these structures was evaluated in basophils from patients with selective reactions to CLV and tolerant subjects. In parallel, the CLV fragments bound to proteins were identified by proteomic approaches.Two synthetic analogs of AD-I were found to activate basophils from allergic patients. This determinant was also detected bound to lysines 195 and 475 of CLV-treated human serum albumin. One of these analogs was able to activate basophils in 59% of patients whereas CLV only in 41%. Combining both results led to an increase in basophil activation in 69% of patients, and only in 12% of controls.We have identified AD-I as one CLV antigenic determinant, which is the drug fragment that remains protein-bound.
STRUCTURAL AND FUNCTIONAL CHANGES BY 3-DIMENSIONAL (3D) TRANSTHORACIC ECHOCARDIOGRAPHY AND GLOBAL LONGITUDINAL STRAIN IN ASYMPTOMATIC PATIENTS WITH BIOPSY-PROVEN NAFLD: RESULTS FROM THE PROSPECTIVE PREVALENCE STUDY
Authors: Anthony Vande Hei, Kelvin Bush, Emilio Fentanes, James Aden, Angelo Paredes, Stephen Harrison, Dustin Thomas
Journal: Journal of the American College of Cardiology (2019)
“<i>Salmonella</i>, meet mycobacteria.”
Authors: Stephanie R. Lovell-Read, Luiz Pedro Sorio de Carvalho
Journal: The Journal of Experimental Medicine (2019)

In this issue of JEM, Reinink et al. (https://doi.org/10.1084/jem.20181812) use comparative lipidomics to identify a new family of trehalose-containing cell wall lipids that are enriched in virulent Salmonella serovars. These lipids are structurally related to the important mycobacterial immunogen cord factor.
ASSOCIATION BETWEEN GERIATRIC ELEMENTS AND ORAL ANTICOAGULANT PRESCRIBING AMONG OLDER ADULTS WITH ATRIAL FIBRILLATION: DATA FROM THE SAGE-AF STUDY
Authors: Saket Sanghai, Summer Aldrugh, Molly Waring, Catarina Kiefe, Robert Goldberg, Jerry Gurwitz, Darleen Lessard, David C. Parish, Hamza H. Awad, Felix Sogade, Robert Helm, Robert Hayward, David McManus, Jane Saczynski
Journal: Journal of the American College of Cardiology (2019)
IMPACT OF HYPERURICEMIA ON PATIENTS WITH DIABETES MELLITUS WHO UNDERWENT PERCUTANEOUS CORONARY INTERVENTION
Authors: Ken Nishikawa, Ayumu Nagae, Takashi Miura, Koki Fujimori, Daisuke Sunohara, Hisanori Yui, Shusaku Maruyama, Chie Nakamura, Hiroaki Tabata, Daisuke Kashiwagi, Hideki Kobayashi, Takahiro Sakai, Keisuke Senda, Tamon Katoh, Tatsuya Saigusa, Soichiro Ebisawa, Ayako Okada, Hirohiko Motoki, Koichiro Kuwahara
Journal: Journal of the American College of Cardiology (2019)
Abstract 586: Early Characterization of the Mechanisms of ATRA-mediated Suppression of Cardiac Hypertrophy
Authors: Lauren Parker, Brian O’Rourke, D. Brian Foster
Journal: Circulation Research (2018)

Pathway analyses of proteomic studies in guinea pig and rat hearts subjected to pressure overload-induced hypertrophy and heart failure (HF) suggest aberrant retinoid signaling may contribute to HF progression. Though the precise mechanisms are unknown, we recently showed that cardiac levels of the hormone all-trans retinoic acid (ATRA) are deficient in human non-ischemic HF patients. This has prompted us to revisit an old, but poorly understood, observation that ATRA suppresses phenylephrine (Phe)-induced hypertrophy in neonatal rat ventricular myocytes (NRVMs). Using confocal microscopy to measure cross-sectional area (CSA) as an index of hypertrophy, we show, consistent with prior work, that ATRA suppresses Phe-induced increases in NRVM CSA by average of 70%. Specifically, treatment groups of maintenance media (MM) alone and MM+Phe+ATRA were significantly different from the MM+Phe treatment group (p&lt;0.005, n&gt;58). ATRA exerts its biological actions through a class of ligand-dependent transcription factors called retinoic acid receptors (RARs), of which there are three forms, a, b and g. To better understand the mechanism by which ATRA exerts its anti-hypertrophic effect in NRVMs, we examined the impact of RARα, RARβ, and RARγ antagonists. The RARβ antagonist LE135 (1mM) fully blocked the action of ATRA (p&lt;0.0001, n&gt;46), while initial studies with the RARa and RARg antagonists (BMS 195614 and MM 11253) failed to significantly mitigate CSA suppression by ATRA. Thus, initial pharmacologic studies indicate ATRA elicits an anti-hypertrophic program, at least in part, through its activation of RARb. Ongoing experiments are aimed at corroborating these observations in NRVMs virally-transduced with shRNA to knock down levels of each of the RAR isoforms. These studies will provide key insights as we begin to delineate the mechanisms by which ATRA dysregulation contributes to HF pathogenesis.
Proteomics Pathways of Sickle Cell Anemia (P2SCA): A Comprehensive Analysis By Liquid Chromatography Mass Spectrometry of Erythrocyte Membrane Proteins Characterized from the Muhimbili Sickle Cell Programme, Tanzania
Authors: Haddy KS Fye, Paul Mrosso, Frédéric B Piel, Simon Davis, Roman Fischer, Gration Rwegasira, Benedikt Kessler, Julie Makani
Journal: Blood (2018)
A PILOT STUDY OF ADVANCE CARE PLANNING IN THE OUTPATIENT CARDIOLOGY SETTING: PRELIMINARY FEASIBILITY AND STUDY DESIGN
Authors: Krystle M. Leung, Charles Blatt, Shmuel Ravid, Brian Bilchik, Kristian Bakken, Donna R. McGrath, Rachelle E. Bernacki, Kristen G. Schaefer, Dara Lee-Lewis
Journal: Journal of the American College of Cardiology (2019)
EFFECT OF TICAGRELOR AND CLOPIDOGREL ON CORONARY MICROCIRCULATION IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
Authors: Marco Antonio Scanavini Filho, Otavio Berwanger, Wilson Mathias, Miguel Osman Aguiar, Hsu Po Chiang, Luciano Moreira Baracioli, Felipe Gallego Lima, Fernando Reis Menezes, Talia Dalçoquio, Remo Holanda M. Furtado, Fabio Augusto De Luca, Delcio Uezato, Jose Antonio Franchini Ramires, Roberto Kalil Filho, Jose Carlos Nicolau
Journal: Journal of the American College of Cardiology (2019)
NEW MURMUR OF AORTIC INSUFFICIENCY IN ACUTE AORTIC DISSECTION
Authors: Stephen Philip, Edward Chen, Stuart Hutchison, Patrick O'Gara, Emil Missov, G. Chad Hughes, Dan Gilon, Lori Conklin, Sherene Shalhub, Ali Khoynezhad, Raffi Bekeredjian, Daniel Montgomery, Guillaume Geuzebroek, Bradley Taylor, Valerio Tolva, Eric Isselbacher, Christoph Nienaber, Kim Eagle
Journal: Journal of the American College of Cardiology (2019)
AGED GARLIC EXTRACT REDUCES LOW ATTENUATION PLAQUE IN CORONARY ARTERIES OF PATIENTS WITH DIABETES IN A PROSPECTIVE RANDOMIZED DOUBLE-BLIND STUDY
Authors: Kashif Shaikh, Lavanya Cherukuri, Divya Birudaraju, Rine Nakanishi, Shone Almeida, Eranthi Jayawardena, Chandana Shekar, Ferdinand Flores, Sajad Hamal, Salman Sheikh, Amit Johanis, Benedict Cu, Matthew Budoff
Journal: Journal of the American College of Cardiology (2019)
Abstract 13245: The Pro-Atherogenic DNA-Binding Cytokine HMGB1 Binds to Activated Platelets via the Receptor for Advanced Glycation End Products (RAGE) and Toll-Like Receptor 2 (TLR 2)
Authors: Ingo Ahrens, Alex Agrotis, Denijal Topcic, Nicole Bassler, Yung-Chih Chen, Alex Bobik, Christoph Bode, Karlheinz Peter
Journal: Circulation (2011)

Background and Rationale: High-mobility group box1 (HMGB1) facilitates gene transcription as an architectural nuclear protein but may also be secreted, thereby mediating inflammatory and immune res...
Characterization of Mechanisms Underlying Acquired Venetoclax-Resistance in Mantle Cell Lymphoma: BDA-366 As a Potential Treatment Option
Authors: Daniela Steinbrecher, Felix Seyfried, Johannes Bloehdorn, Billy Michael Chelliah Jebaraj, Lüder Hinrich Meyer, Hartmut Döhner, Stephan Stilgenbauer, Christof Schneider
Journal: Blood (2018)
COMPARISON OF PERCUTANEOUS MITRAL VALVE REPAIR AND OPTIMAL MEDICAL THERAPY VERSUS OPTIMAL MEDICAL THERAPY ALONE FOR PATIENTS WITH SEVERE FUNCTIONAL MITRAL REGURGITATION: AN UPDATED META-ANALYSIS
Authors: Manuel Rivera, Neal Olarte, Leonardo Knijnik, Alexander Toirac, Amanda Fernandes, Gilson Fernandes
Journal: Journal of the American College of Cardiology (2019)
SUPPRESSING PHYSIOLOGIC 18-FLUORODEOXYGLUCOSE UPTAKE IN PATIENTS UNDERGOING POSITRON EMISSION TOMOGRAPHY FOR CARDIAC SARCOIDOSIS: THE EFFECT OF A STRICT DIETARY PROTOCOL
Authors: Georgios Christopoulos, Hayan Jouni, Gayatri Acharya, Panithaya Chareonthaitawee, Martin Rodriguez-Porcel
Journal: Journal of the American College of Cardiology (2019)
PROBE MULTICENTRE STUDY, TO COMPARE LONG-TERM ADHERENCE OF SECONDARY PREVENTION MEASURES, AFTER AN ACUTE CORONARY SYNDROME, OF AN INTENSIVE CARDIAC REHABILITATION PROGRAM VERSUS A STANDARD PROGRAM
Authors: Almu Castro, Regina Dalmau, Vicente Ignacio Arrarte Esteban, Fernando Garza Benito, Rafael Hidalgo, Rafael Vidal, Joan Torres Marques, Manuel Abeytua
Journal: Journal of the American College of Cardiology (2019)
BRAIN-HEART CONNECTION: ALTERED MENTAL STATUS AS A PRESENTING SYMPTOM OF ATRIOESOPHAGEAL FISTULA AFTER CATHETER ABLATION OF ATRIAL FIBRILLATION
Authors: Prashanth Venkatesh, Eric Yang, Eric Buch, Houman Khakpour, Brenton Bauer, Janet Han
Journal: Journal of the American College of Cardiology (2019)
PROGNOSIS BASED ON CHARACTERISTICS OF NON-TREATED EDGE DISSECTIONS AS DETECTED BY OPTICAL COHERENCE TOMOGRAPHY
Authors: Mariusz Tomaniak, Laurens J.C. Zandvoort, Maria N. Tovar Forero, Ken Masdjedi, Lisanne Visseren, Karen Witberg, Jurgen Ligthart, Miguel M. Lemmert, Roberto Diletti, Jeroen Wilschut, Peter de Jaegere, Felix Zijlstra, Nicolas Van Mieghem, Joost Daemen
Journal: Journal of the American College of Cardiology (2019)
DISCORDANT TRICUSPID ANNULAR PLANE SYSTOLIC EXCURSION AND GLOBAL RIGHT VENTRICULAR FUNCTION IN PULMONARY ARTERIAL HYPERTENSION: IMPACT OF RIGHT VENTRICULAR GEOMETRY AND TRICUSPID REGURGITATION
Authors: Abhishek Chaturvedi, Mitha Naik, Jose Ricardo Po, Talha Meeran, Amresh Raina
Journal: Journal of the American College of Cardiology (2019)
INTER-OBSERVER DIFFERENCES IN INTERPRETATION OF PRESSURE-WIRE PULLBACK TRACES
Authors: Takayuki Warisawa, James P. Howard, Christopher Cook, Yousif Ahmad, Shunichi Doi, Masafumi Nakayama, Sonoka Goto, Yohei Yakuta, Kenichi Karube, Fumiyasu Seike, Teruyoshi Uetani, Tadashi Murai, Yuetsu Kikuta, Yasutsugu Shiono, Yoshiaki Kawase, Toshiki Kaihara, Takumi Higuma, Yuki Ishibashi, Hisao Matsuda, Hidetaka Nishina, Hitoshi Matsuo, Javier Escaned, Darrel Francis, Yoshihiro Akashi, Justin Davies
Journal: Journal of the American College of Cardiology (2019)
CLINICAL INDICATORS AND CORONARY ANGIOGRAPHIC FEATURES OF EXPANSIVE ARTERY REMODELING IN PATIENTS WITH ABDOMINAL AORTIC ANEURYSM
Authors: Hirohisa Endo, Tomotaka Dohi, Shizuyuki Dohi, Hideki Wada, Shinichiro Doi, Yoshiteru Kato, Iwao Okai, Hiroshi Iwata, Shinya Okazaki, Kikuo Isoda, Taira Yamamoto, Katsumi Miyauchi, Atsushi Amano, Hiroyuki Daida
Journal: Journal of the American College of Cardiology (2019)
CORRELATION OF CARDIAC DEVICE-RELATED MASSES AND INFECTIVE ENDOCARDITIS
Authors: Ayman Elbadawi, Nishit Biniwale, Muhammad Waqas Tahir, Erfan Alotaki, Mohamed Faher Almahmoud, Amr Barakat, Matthew Funderburk, Ann R. Falsey
Journal: Journal of the American College of Cardiology (2019)
GENDER DIFFERENCES IN BASELINE CHARACTERISTICS DO NOT PREDICT EARLY OUTCOMES AFTER PERCUTANEOUS CORONARY INTERVENTION: RESULTS FROM THE AUSTRALIAN GENESIS CARDIOVASCULAR OUTCOMES REGISTRY (GCOR)
Authors: Andre Conradie, Stephen G. Worthley, Enayet Chowdhury, Tony Rafter, Alan Whelan, David Eccleston
Journal: Journal of the American College of Cardiology (2019)
Evaluation of Lymph Node Ratio Association With Long-term Patient Survival After Surgery for Node-Positive Merkel Cell Carcinoma
Authors: Shayan Cheraghlou, George O. Agogo, Michael Girardi
Journal: JAMA Dermatology (2019)

Merkel cell carcinoma (MCC) carries the highest mortality rate among cutaneous cancers and is rapidly rising in incidence. Identification of prognostic indicators may help guide patient counseling and treatment planning. Lymph node ratio (LNR), the ratio of positive lymph nodes to the total number of examined lymph nodes, is an established prognostic indicator in other cancers.The primary objective was to evaluate the association between LNR and patient survival after surgery for node-positive MCC. The secondary objective was to evaluate whether the survival rates associated with adjuvant therapies vary by patient LNR status.Retrospective cohort study of patients with node-positive MCC treated with surgery and lymphadenectomy. We queried the National Cancer Database (NCDB) and the Surveillance, Epidemiology, and End Results (SEER) registry for patient records. Data originated from 2004 through 2017 for the NCDB and from 1973 through 2016 for the SEER registry. The SEER registry comprises a population-based US cohort while cases from the NCDB include all reportable cases from Commission on Cancer-accredited facilities and represents approximately 70% of all newly diagnosed cancers in the United States. All data analysis took place between August 1, 2018, and February 11, 2019.The ratio of positive lymph nodes to the total number of examined lymph nodes, LNR, was stratified into quartiles.Overall survival (NCDB) and disease-specific survival (SEER).We identified 736 eligible cases in the NCDB and 538 eligible cases in the SEER registry. Among these 1274 patients, the mean (SD) age was 71.1 (11.5) years, and 401 (31.5%) were women. After controlling for clinical and tumor factors including AJCC N staging, patient LNR of 0.07 to 0.31 (hazard ratio [HR], 1.37; 95% CI, 1.03-1.81) and greater than 0.31 (HR, 2.84; 95% CI, 2.10-3.86) was associated with significantly worse survival than an LNR less than 0.07. Univariate supplementary analysis performed in the SEER data set revealed a similar association of LNR with disease-specific survival. For patients with an LNR greater than 0.31, treatment with surgery and adjuvant chemoradiation therapy was associated with improved survival compared with surgery and adjuvant radiation therapy alone (HR, 0.61; 95% CI, 0.38-0.97), while this was not found for patients with an LNR of 0.31 or lower (HR, 0.93; 95% CI, 0.65-1.33).For lymph node-positive MCC, LNR offers a potentially prognostic metric alongside traditional TNM staging that may be useful for both patient counseling and treatment planning after surgery.
Abstract 112: Doxorubicin Alters Cardiac Fibroblast Phenotype
Authors: Trevi R Mancilla, Gregory J Aune
Journal: Circulation Research (2018)

The oldest cohort of childhood cancer survivors are entering into their sixth decade. The milestone comes with the knowledge that this population is at a 15 times greater risk of cardiovascular events than the general population. One factor in this is doxorubicin, a chemotherapeutic drug commonly used to treat pediatric cancers. Our study investigates the effect of doxorubicin on proliferating cells in the heart, specifically, cardiac fibroblasts. Doxorubicin inhibits cardiac fibroblast growth and migration. Cardiac fibroblasts also undergo a shift in gene expression when exposed to doxorubicin. Inflammatory cytokines and their receptors are upregulated, along with extracellular matrix regulatory proteins. ECM structural proteins and adhesion molecules are downregulated compared to control cells. Of note, monocyte chemoattractant protein-1, and its receptor C-C motif chemokine receptor-4, are upregulated over 40-fold compared to control cells. Doxorubicin has multiple mechanisms of actions that target proliferating and non-proliferating cells differently. Cardiac fibroblasts are proliferative cells with a major role in multiple processes of cardiac homeostasis. This study lays the foundation of the phenotypic changes cardiac fibroblasts undergo when exposed to doxorubicin. These changes may create a microenvironment that primes the heart for adverse cardiac remodeling.
Abstract 10878: Validation of Non-invasive Measures of Diastolic Function in Children: A Simultaneous Echocardiography and Conductance Catheterization Study
Authors: Shahryar M Chowdhury, Ryan J Butts, Anthony M Hlavacek, Carolyn L Taylor, Varsha M Bandisode, Karen S Chessa, Girish S Shirali, Arni Nutting, George H Baker
Journal: Circulation (2015)

Introduction: The accuracy of echocardiography in evaluating left ventricular (LV) diastolic function has not been validated in children. The objective of this study was to compare echocardiographic and gold-standard measures of LV diastolic function in children. Methods: Patients undergoing routine left heart catheterization were prospectively enrolled. Pressure-volume loops (PVL) were obtained via conductance catheters. The end-diastolic pressure-volume relationship was obtained via balloon occlusion of the vena cavae. PVL measures of diastolic function were divided into early active relaxation (the isovolumic relaxation time constant, tau), and ventricular stiffness (the chamber stiffness constant, β). End-diastolic pressure (EDP) was also recorded. Echocardiographic measures of diastolic function were derived from spectral Doppler, tissue Doppler, and 2D speckle-tracking. The relationships between PVL and echocardiographic measures were determined using Spearman’s correlation. Results: Of 24 patients, 18 patients were s/p heart transplant, 5 patients had a small patent ductus arteriosus or coronary fistula. Mean age was 9.1 ± 5.6 years. The median τ was 24.9 ms (IQR 22.8 - 28.4 ms), median β was 0.094 (IQR 0.035 - 0.154), and median EDP was 9 mmHg (IQR 8 - 13 mmHg). Statistically significant correlations between invasive and echocardiographic measures of diastolic function are reported in the Table. No echocardiographic measures correlated with β. Conclusion: Early diastolic echocardiographic measures correlate with tau and may accurately represent early active relaxation in children. Modest associations exist between echocardiographic measures and EDP. The use of these non-invasive measures in accurately assessing LV diastolic function appears promising in children. However, no echocardiographic measures correlate with chamber stiffness. The development of such measures merits further study.
ONE-YEAR MAJOR ADVERSE LIMB EVENTS AND PLANNED REVASCULARIZATIONS FOLLOWING INVASIVE VERSUS OPTIMAL MEDICAL THERAPY FOR NEW OR WORSENING OF CLAUDICATION SYMPTOMS: INSIGHTS FROM THE PORTRAIT REGISTRY
Authors: Kim Smolderen, David Safley, Philip Jones, Manesh Patel, Schuyler Jones, Mehdi Shishehbor, Herbert Aronow, Clementine Labrosciano, Christine Fuss, Kate Scott, Nancy Stone, John A. Spertus
Journal: Journal of the American College of Cardiology (2019)
BRUGADA SYNDROME: TAILORING GENETIC TESTING FOR CLINICAL PHENOTYPE
Authors: Rahul Vasudev, Rana Garris, Nirmal Guragai, Upamanyu Rampal, Hiten Patel, Priyank Shah, Bader Abu Ghalyoun, Mahesh Bikkina, Fayez Shamoon, Punita Gupta, Satish Tiyyagura
Journal: Journal of the American College of Cardiology (2019)