THU0627 Demographics and presenting organ involvement in a cohort of patients with sarcoidosis
Authors: K. Sheth, G. Jeyashanmugaraja, J. Simard, S. Shoor
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Sarcoidosis is a multisystem disorder of unknown etiology characterised pathologically by non-caseating granulomas in involved organs. Although mortality is reported in only 1%–5% of patients, there is data suggesting it might be increasing and there is little information about the clinical and epidemiological characteristics of this group of patients. <h3>Objectives</h3> To compare basic demographics of a cohort of deceased sarcoid patients with a non-deceased sarcoid population, and to describe the presenting organ involvement among the deceased sarcoid population. <h3>Methods</h3> Patients seen at the Stanford University Hospital and Clinics from 2009–2017 who were &gt;18 years of age with at least one ICD-9 or 10 diagnosis of sarcoidosis and at least one clinical note with the term "sarcoidosis" were identified by EMR. After determining the demographics of this cohort, deceased patients were identified and an extensive chart review of these subset of patients was conducted. The project was approved by Stanford's Institutional Review Board. <h3>Results</h3> 1190 adult patients with an ICD code for sarcoidosis were identified. Demographic comparison between the non-deceased and deceased population is summarised in the table 1 below. In comparison with non-deceased patients with sarcoidosis, the proportion of African American population was higher in the deceased population, whereas the proportion of Asians and whites was lower in the deceased population. The percentage of male patients in the deceased subset was slightly higher than the non-deceased population. 65 (62.5%) of the 104 deceased patients were symptomatic at diagnosis, 6 (5.8%) were asymptomatic and information was not available for 33 (31.7%) patients. Of the 65 symptomatic patients, presenting organ involvement was either pulmonary(34, 52.3%), cardiac(11,16.9%), cutaneous(8,12.3%), neurological(4,6.2%), ocular(3, 4.6%), constitutional(5,7.7%), unknown(1,1.5%), musculoskeletal(1,1.5%), renal–calcium related(1,1.5%), hepatic(2,3%), laryngeal(1,1.5%), nasal and sinus(2,3%), parotid gland(1,1.5%), gastrointestinal(1,1.5%), or others (5,7.6%). <h3>Conclusions</h3> This study compares the demographics of subset of deceased sarcoid patients with a population of non-deceased sarcoid patients, and describes the presenting organ involvement among the deceased sarcoid population. African American males had a higher mortality rate compared to Asians and Caucasians. Pulmonary and cardiac disease represented 69.2% of organ involvement in the deceased. Our study showed a mortality rate of 8.7% in the sarcoid population which is in keeping with the newer studies that mortality in patients with sarcoid might be on the rise. With further study of this population, we aim to compare the characteristics of non-deceased sarcoid patients with the deceased patients, including presenting organ involvement, diagnostic workup and treatment regimen and hope to gain a better understanding of the possible reasons for increasing mortality in patients with sarcoidosis. <h3>Disclosure of Interest</h3> None declared