tbuckley/cabot-search huggingface dataset:
The Post-COVID-19 Functional Status scale: a tool to measure functional status over time after COVID-19
Authors: Frederikus A. Klok, Gudula J.A.M. Boon, Stefano Barco, Matthias Endres, J.J. Miranda Geelhoed, Samuel Knauss, Spencer A. Rezek, Martijn A. Spruit, Jörg Vehreschild, Bob Siegerink
Journal: European Respiratory Journal (2020)

<b>An ordinal tool is proposed to measure the full spectrum of functional outcomes following COVID-19. This "Post-COVID-19 Functional Status (PCFS) scale" can be used for tracking functional status over time as well as for research purposes.</b>https://bit.ly/3cofGaa
EUS-GUIDED DRAINAGE USING LUMEN APPOSING METAL STENT AND TRANSCUTANEOUS ENDOSCOPIC NECROSECTOMY AS DUAL APPROACH FOR THE MANAGEMENT OF COMPLEX WALLED-OFF NECROSIS. A CASE REPORT
Authors: C Binda, M Sbrancia, E Giampalma, D Colussi, V Agnoletti, A Taioli, L Ansaloni, N Fabbri, C Fabbri
Journal: Endoscopy (2020)

A 61 years old man after 3 weeks from the onset of acute necrotizing pancreatitis (ANP) developed signs of severe sepsis. The CT scan showed a large WOPN, with extension to the pelvic paracolic gutter, so he underwent to EUS-guided drainage using EC-LAMS. After an initial resolution of sepsi, 3 weeks later the patient developed multiorgan failure (MOF). The CT-scan showed an increase of the amount of necrosis to the pelvic paracolic gutter. Therefore, we placed an esophageal SEMS transcutaneously and performed 5 sessions of necrosectomy. The patient rapidly resolved sepsi and a complete resolution of the necrosis was obtained.
Inefficiencies and High-Value Improvements in U.S. Cervical Cancer Screening Practice
Authors: Jane J. Kim, Nicole G. Campos, Stephen Sy, Emily A. Burger, Jack Cuzick, Philip E. Castle, William C. Hunt, Alan Waxman, Cosette M. Wheeler
Journal: Annals of Internal Medicine (2020)

Variability in cervical cancer screening practices may result in inefficiencies in the diagnosis and treatment of cervical cancer in women. This cost-effectiveness analysis compares the effect of c...
ENDOSCOPIC DRAINAGE OF PANCREATIC AND PERI-PANCREATIC COLLECTIONS: A RETROSPECTIVE ANALYSIS
Authors: C Correia, N Almeida, F Portela, D Gomes, A Fernandes, A Rosa, P Figueiredo
Journal: Endoscopy (2020)

Aims Pancreatic/peri-pancreatic fluid collections (PFC) are a common complication of acute or chronic pancreatitis. Symptomatic pseudocysts (PP) and encapsulated necrotic collections (WOPN) require treatment, being endoscopic drainage one of the therapeutic options. The aim of this study is evaluating the efficacy and safety of endoscopic drainage in the treatment of PP and WOPN.
HEMORRHAGIC RISK IN POST AMPULLECTOMY PATIENTS ON ANTITHROMBOTIC THERAPY
Authors: C Meunier, V Gupta, AI Lemaistre, F Fumex, R Gincul, C Lefort, V Lepilliez, R Bourdariat, B Napoléon
Journal: Endoscopy (2020)

Aims Endoscopic ampullectomy (EA) can cure ampullary adenomas. However, the morbidity remains high including 10% risk of bleeding .The primary objective of this single-centre study was to determine whether patients treated with antiplatelet or anticoagulant therapy (VKA) had increased morbidity or mortality risk.
KI-67-INDEXING OF EUS-GUIDED FINE NEEDLE BIOPSY SPECIMENS FOR THE PREOPERATIVE GRADING OF PANCREATIC NEUROENDOCRINE TUMORS
Authors: F Bergstedt, A Appelstrand, AK Elf, H Fagman, P Hedenström
Journal: Endoscopy (2020)

Aims A reliable preoperative grading of pancreatic neuroendocrine tumors (PanNET) is important to assess the prognosis and to determine the clinical managment - surgical resection vs active follow-up. EUS-guided fine-needle biopsy sampling (EUS-FNB) is a promising tool for this task.
FUSION RADIOLOGY FOR ENDOSCOPIC DRAINAGE OF PANCREATIC FLUID COLLECTIONS: AN INNOVATIVE SINGLE CENTER EXPERIENCE
Authors: R Sassatelli, S Grillo, P Cecinato, V Iori, G Besutti, M Ottone, PG Rossi, G Sereni, M Cavina, S Arona, F Bassi, MC Campanale, F Decembrino, M Lucarini, VG Mirante, F Parmeggiani, C Tioli
Journal: Endoscopy (2020)

Aims Virtual reality obtained by the fusion of images can be applied to several fields of medicine leading to the so-called “augmented reality”. Since 2017 we have been using a new digital angiographic system (Discovery IGS 40, General Electrics) in biliopancreatic endoscopy, where fluoroscopy can be fused with pre-procedural CT o MRI. Specifically the present study aimed at verifying the advantages that fusion imaging could bring in EUS-guided drainage of post-pancreatitis fluid collection (PFC), i.e. pseudocysts or WON, in terms of more appropriate visualization, drainage approach and time needed for resolution.
A POTENTIAL SIMPLE ENDOSCOPIC ANTIREFLUX METHOD, ‘THE RIPPLE PROCEDURE’ IN PORCINE MODEL
Authors: SK Shin, H Chung, SH Kim, YC Lee
Journal: Endoscopy (2020)

Aims Currently available endoscopic or minimally invasive antireflux modalities are not widely accepted due to high procedure cost or inconsistent results. Therefore, a simpler and less technically demanding method is required. We evaluated the feasibility and efficacy of new endoscopic antireflux method (the Ripple procedure) using functional lumen imaging probe (FLIP).
PREDICTORS OF POST BANDING-ULCER BLEEDING AFTER ENDOSCOPIC VARICEAL LIGATION
Authors: M Ayari, Y Zaimi, EBH Mabrouk, S Ayadi, L Mouelhi, R Debbeche
Journal: Endoscopy (2020)

Aims Bleeding related to post banding-ulcer is a rare life-threatening complication of endoscopic variceal ligation (EVL) in cirrhotic patients with esophageal varices (EV). The aim of this study was to determine the incidence and predictive factors of EVL induced ulcer bleeding.
Incidence trend of five common musculoskeletal disorders from 1990 to 2017 at the global, regional and national level: results from the global burden of disease study 2017
Authors: Ziyi Jin, Dandan Wang, Huayong Zhang, Jun Liang, Xuebing Feng, Jinkou Zhao, Lingyun Sun
Journal: Annals of the Rheumatic Diseases (2020)

To assess cause-specific incidence and its trend of musculoskeletal (MSK) disorders at global, regional and national levels.Data on MSK disorders were downloaded from the Global Burden of Disease 2017 study website. Estimated annual percentage change (EAPC) was calculated to quantify the temporal trend in age-standardised incidence rate (ASR) of MSK disorders, by age, sex, region and cause.Between 1990 and 2017 incident cases of MSK disorders increased globally by 58% from 211.80 million to 334.74 million, with a decreasing ASR of 0.18% annually (95% CI -0.21% to -0.15%). The ASR decreased for low back pain (LBP), remained stable for neck pain (NP), and increased for rheumatoid arthritis (RA), osteoarthritis (OA) and gout, with EAPCs (95% CI) of -0.24 (-0.29 to -0.20), -0.09 (-0.13 to -0.05), 0.36 (0.28 to 0.43), 0.32 (0.28 to 0.36) and 0.22 (0.21 to 0.23), respectively. It appears women have higher increase in EAPC than men for RA (1.3 times) and gout (1.6 times). The absolute EAPC was strikingly high in high or high-middle sociodemographic index (SDI) regions for overall, LBP and gout, and in low SDI regions for NP. EAPC was significantly associated with baseline ASR for LBP (nonlinear), RA (ρ=-0.41) and gout (ρ=-0.42), also with 2017 human development index for LBP (ρ=-0.53) and gout (ρ=0.15).Globally, MSK disorders remain a public health burden. The ASR is decreasing for MSK disorders overall, mainly in high-middle SDI regions, but increasing for RA, OA and gout.
PREVALENCE OF GASTROINTESTINAL DISEASE IN AN ASYMPTOMATIC POPULATION USING VIDEOCAPSULE
Authors: FER Vuik, SAV Nieuwenburg, S Moen, EH Schreuders, C Spada, O Epstein, I Fernández-Urién, I Lansdorp-Vogelaar, EJ Kuipers, MCW Spaander
Journal: Endoscopy (2020)

Aims Although gastrointestinal (GI) diseases are common, prevalence rates of lesions in the GI tract in an asymptomatic population are difficult to assess. Colon capsule endoscopy (CCE) is a safe, minimally invasive tool that images the entire GI tract. The aim of this study is to assess prevalence of lesions in the entire GI tract in an asymptomatic population by CCE.
Radiation-Induced Breast Cancer Incidence and Mortality From Digital Mammography Screening
Authors: Diana L. Miglioretti, Jane Lange, Jeroen J. van den Broek, Christoph I. Lee, Nicolien T. van Ravesteyn, Dominique Ritley, Karla Kerlikowske, Joshua J. Fenton, Joy Melnikow, Harry J. de Koning, Rebecca A. Hubbard
Journal: Annals of Internal Medicine (2016)

This modeling study, conducted to inform the new recommendation on breast cancer screening from the U.S. Preventive Services Task Force (USPSTF), examines radiation-induced breast cancer incidence ...
School Closure During the Coronavirus Disease 2019 (COVID-19) Pandemic
Authors: Susanna Esposito, Nicola Principi
Journal: JAMA Pediatrics (2020)

An Effective Intervention at the Global Level?In most countries, attempts to reduce severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) circulation and new coronavirus disease 2019 (COVID-19) development have been mainly based on restrictive measures, including the avoidance of social interactions, the prohibition of movements within the national territory, and the closureofallnonessentialactivities,includingschools.While the closure of factories and the avoidance of other social interaction together with proper hand washing remain the best measures to reduce the total burden of COVID-19, the usefulness of school closure can be debated.It is highly likely that the most important reason leadinggovernmentstocloseschoolswastheevidencethatthe early introduction of this restrictive measure had been effective in reducing influenza incidence rates and related clinical,social,andeconomicproblemsduringbothseasonal and pandemic influenza outbreaks. 1However, it is not at all certain that the same advantages can be expected in the case of the COVID-19 pandemic.It is even possible that schoolclosuremayhavenegativeeffectsandleadtogreater medical, economic, and social problems.Modeling studies seem to indicate that school closure can be significantly effective for infection control only when the outbreaks are due to viruses with low transmissibility and attack rates are higher in children than in adults.This applies to influenza viruses and influenza infection but does not seem valid for coronaviruses,includingSARS-CoV-2,whichhavedifferent transmission dynamics, or for COVID-19, which affects mainlyadultsandelderlyindividuals.Ithasbeencalculated that the expected number of cases directly generated by 1 case of SARS-CoV-2 infection (R 0 ) is high and not lower than 2.5. 2 Moreover, children younger than 10 years account for only 1% of COVID-19 cases, 3 and although a certain number of them can experience an asymptomatic infection, the total number of children with SARS-CoV-2 infection seems lower than expected.Although no official data are available, to our knowledge, on the effectiveness of school closure during the COVID-19 epidemic, the poor relevance of this restrictive measure seems confirmed by the evidence that in Taiwan, the spread of COVID-19 was minimized without widespread planned school closures. 4n the other hand, using UK population and school data together with data on SARS-CoV-2 transmission dynamics calculated in the early COVID-19 pandemic in China, it was predicted that school closure would be insufficient to mitigatethepandemic.Finally,thepooreffectofschoolclosure during coronavirus epidemics has already been evidenced in some studies carried out during the SARS epidemic.In China,itwasfoundthatschoolclosurefor2monthswasnot significantlyeffectivefordiseasepreventionmainlybecause of the very low incidence of symptomatic disease among school-aged children. 5Moreover, in Taiwan, it was evidenced that the risk of transmission of infection among
First-line pembrolizumab and trastuzumab in HER2-positive oesophageal, gastric, or gastro-oesophageal junction cancer: an open-label, single-arm, phase 2 trial
Authors: Yelena Y Janjigian, Steven B Maron, Walid K Chatila, Brittanie Millang, Shweta S Chavan, Carly Alterman, Joanne F Chou, Michal F Segal, Marc Z Simmons, Parisa Momtaz, Marina Shcherba, Geoffrey Y Ku, Alice Zervoudakis, Elizabeth S Won, David P Kelsen, David H Ilson, Rebecca J Nagy, Richard B Lanman, Ryan N Ptashkin, Mark T A Donoghue, Marinela Capanu, Barry S Taylor, David B Solit, Nikolaus Schultz, Jaclyn F Hechtman
Journal: The Lancet Oncology (2020)
LARGE NON-PEDUNCULATED COLORECTAL POLYPS/COMPLEX POLYPS MDT ORGANISATION AND PRACTICE ACROSS YORKSHIRE REGION, UK
Authors: A Al-Rifaie, E Said, S Riley, M Thoufeeq
Journal: Endoscopy (2020)

Aims The British Society of Gastroenterology published guidance on the management of large non-pedunculated polyps in 2015. The aim of this survey was to assess the organisation and practice of complex polyps MDT across the Yorkshire region, UK.
THE JOINT ADVISORY GROUP ON GI ENDOSCOPY (JAG) SURVEY OF UK ENDOSCOPY SERVICES: RESULTS FROM THE 2019 CENSUS
Authors: S Ravindran, T Shaw, M Dron, R Broughton, H Griffiths, C Healey, J Green, H Ashrafian, A Darzi, S Thomas-Gibson
Journal: Endoscopy (2020)

Aims To understand factors related to endoscopy quality, workforce and training across services in the UK.
Efficacy of Anti-EGFR in Microsatellite Instability Metastatic Colorectal Cancer Depending on Sporadic or Familial Origin
Authors: Aziz Zaanan, Julie Henriques, Romain Cohen, David Sefrioui, Camille Evrard, Christelle de la Fouchardiere, Thierry Lecomte, Thomas Aparicio, Magali Svrcek, Julien Taieb, Thierry André, Dewi Vernerey, David Tougeron
Journal: JNCI Journal of the National Cancer Institute (2020)

Abstract Anti-epidermal growth factor receptor (EGFR) efficacy in patients with microsatellite instability (MSI) metastatic colorectal cancer (mCRC) according to sporadic vs familial origin is unknown. We retrospectively analyzed 128 patients with MSI mCRC treated with first-line chemotherapy ± anti-EGFR. Among them, 61 and 67 patients were respectively categorized as familial and sporadic based on mismatch repair protein immunostaining, BRAF mutational status, and MLH1 promoter methylation status. We observed that addition of anti-EGFR to chemotherapy was associated with a statistically significant improvement of progression-free survival for familial (median = 5.0 vs 10.2 months, hazard ratio [HR] = 0.47, 95% confidence interval [CI] = 0.23 to 0.94; P = .03) but not for sporadic (median = 4.4 vs 5.4 months, HR = 0.80, 95% CI = 0.39 to 1.60; P = .52) MSI mCRC patients. In multivariate analysis, the survival benefit of adding anti-EGFR to chemotherapy remained statistically significant for familial MSI cases (P = .04). These findings deserve to be confirmed in a prospective study and could help decision making in MSI mCRC without access or resistant to immunotherapy.
Modern Trends in Public Health
Authors: R C Wofinden
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Renal Function in Donors and Recipients of Renal Allotransplantation
Authors: James V. Donadio, Charles D. Farmer, James C. Hunt, W. Newlon Tauxe, George A. Hallenbeck, Roy G. Shorter
Journal: Annals of Internal Medicine (2020)

Excerpt In patients with renal allografts, serial determinations of renal function are of prognostic significance. Trends in renal function may be considered as reflecting a balance between effecti...
EFFICACY OF EARLY ERCP IN PRIMARY AND SECONDARY DISTAL MALIGNANT BILIARY OBSTRUCTION
Authors: JK Ryu, S H Lee, Y-T Kim
Journal: Endoscopy (2020)

Aims Early endoscopic retrograde cholangiopancreatography (ERCP) in patients with acute cholangitis, mainly from biliary stones, is known to improve outcomes. Currently, there is a lack of studies regarding optimal timing of ERCP in patients with malignant biliary obstruction (MBO).
COMPARISON OF LIQUID-BASED CYTOLOGY WITH CONVENTIONAL SMEAR CYTOLOGY FOR ENDOSCOPIC ULTRASOUND-GUIDED FINE NEEDLE ASPIRATION OF SOLID PANCREATIC MASSES: PROSPECTIVE RANDOMIZED NON-INFERIORITY STUDY
Authors: YT Kim, SH Lee, YJ Hwang, K Lee, H Kim, JW Chun, WH Paik, JK Ryu
Journal: Endoscopy (2020)

Aims There is limited data on the efficacy of liquid-based cytology (LBC) for endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) specimens. We aimed to evaluate the diagnostic efficacy of LBC for solid pancreatic neoplasms compared to conventional smears (CS).
THE EVOLUTION OF GASTROOESOPHAGEAL VARICES IN NON CIRRHOTIC PORTAL HYPERTENSION BY INFRA-HEPATIC BLOCK
Authors: MEl Mountassir, I Benelbarhdadi, F Laamarti, S Zertiti, H Boutalaka, C Berhili, N Lagdali, M Borahma, F Ajana
Journal: Endoscopy (2020)

Aims The aim of this study is to specify the evolution of oesogastric varices and thus haemorrhagic recurrence risk in patients with portal hypertension (PHT) by portal vein thrombosis (PVT).
ORGANIC ESOPHAGEAL STENOSIS: ETIOLOGIES AND MANAGEMENT
Authors: M Borahma, S Zertiti, N Lagdali, C Berhili, I Benelbarhdadi, FZ Ajana
Journal: Endoscopy (2020)

Aims Oesophageal stenosis is a frequent pathology confronted in endoscopy. The clinical presentation is mostly a progressive dysphagia with a negative impact on the quality of life. One of the main therapeutic approaches is endoscopic dilatation.
Abstract 10951: Mitochondrial Fusion Promoter Effectively Attenuates Left Ventricular Dysfunction via Improving Cardiac Mitochondrial Function and Dynamics in Rats With Ischemia Reperfusion Injury
Authors: Chayodom Maneechote, Siripong Palee, Sasiwan Kerdphoo, Thidarat Jaiwongkam, Siriporn C Chattipakorn, Nipon Chattipakorn
Journal: Circulation (2018)

Introduction: An increase in mitochondrial fission and decrease in mitochondrial fusion have been associated with myocardial apoptosis and increased infarct size during cardiac ischemia-reperfusion...
Aspergillus spp. in Patients with Chronic Lung Disease in Colombia : Prevalence of Increased Serum IgE, Aspergillus Sensitization and Colonization Chronic Obstructive Lung Disease COPD
Authors: Alejandra Cañas Arboleda, Carlos Álvarez Moreno, P. Le Pape, B. Ariza, E. Robinson, J. Alvarado, A. Caballero, A. Montanez
Journal: American Journal of Respiratory and Critical Care Medicine (2018)
Plan to digitise NHS will fall short without extra investment, says spending watchdog
Authors: Gareth Iacobucci
Journal: BMJ (2020)

Ambitious plans to transform digital services in the NHS in England over the next decade are unlikely to be achieved without substantial extra funding, the government’s spending watchdog has warned.

In a report published on 15 May the National Audit Office said that progress towards the government’s 2014 digital strategy for the NHS had been slower than expected, including a failure to deliver a headline target of a paperless health service by 2018.1

NHS trusts now have a revised target to reach a “core level of digitisation” by 2024. But the NAO said it was “not convinced” that lessons from previous “expensive and largely unsuccessful” attempts at NHS digital transformation were being applied to the current strategy, launched …
USEFULNESS OF ENTEROSCOPIC BALLOON DILATATION IN DIFFERENTIAL DIAGNOSIS OF SMALL BOWEL STRICTURE
Authors: JS Kim
Journal: Endoscopy (2020)

Aims The complications of non-steroid anti-inflammatory drugs (NSAIDs) and low dose aspirin can be presented as gastrointestinal ulceration, bleeding, perforation and stricture. The stricture is the most severe stage of NSAID enteropathy which causes obstruction of small bowel. Occasionally, this lesion can be confused with crohn’s disease stricture. Nowadays, balloon dilatation through enteroscope is available, can create a more dilated lumen by expanding force, which permit the passage of a enteroscope and accurate evaluation of more proximal or distal small bowel above the stricture, We report our experiences and outcomes of small bowel evaluation above the stricture after balloon dilatation.
SUBMUCOSAL TUNNELING ENDOSCOPIC SEPTUM DIVISION OF A ZENKER DIVERTICULUM(Z-POEM)
Authors: K Delis, I Robotis, E Sachitzi, S Labrinakos
Journal: Endoscopy (2020)

Aim Endoscopic treatment of a 73 years old female with a symptomatic 3.5 cm Zenker’s diverticulum (ZD).
Alpelisib (BYL719) Plus Fulvestrant in PIK3CA-Altered and PIK3CA-Wild-Type ER+ Advanced Breast Cancer
Authors: D Juric, F Janku, J Rodon, H A Burris, I A Mayer, M Schuler, R Seggewiss-Bernhardt, M Gil-Martin, M Middleton, J Baselga, D Bootle, D Demanse, L Blumenstein, K Schumacher, A Huang, C Quadt, H S Rugo
Journal: JAMA Oncology (2018)
Ventricular fibrillation mechanism and global fibrillatory organization are determined by gap junction coupling and fibrosis pattern
Authors: Balvinder S Handa, Xinyang Li, Nicoleta Baxan, Caroline H Roney, Anastasia Shchendrygina, Catherine A Mansfield, Richard J Jabbour, David S Pitcher, Rasheda A Chowdhury, Nicholas S Peters, Fu Siong Ng
Journal: Cardiovascular Research (2020)

Abstract Aims Conflicting data exist supporting differing mechanisms for sustaining ventricular fibrillation (VF), ranging from disorganized multiple-wavelet activation to organized rotational activities (RAs). Abnormal gap junction (GJ) coupling and fibrosis are important in initiation and maintenance of VF. We investigated whether differing ventricular fibrosis patterns and the degree of GJ coupling affected the underlying VF mechanism. Methods and results Optical mapping of 65 Langendorff-perfused rat hearts was performed to study VF mechanisms in control hearts with acute GJ modulation, and separately in three differing chronic ventricular fibrosis models; compact fibrosis (CF), diffuse fibrosis (DiF), and patchy fibrosis (PF). VF dynamics were quantified with phase mapping and frequency dominance index (FDI) analysis, a power ratio of the highest amplitude dominant frequency in the cardiac frequency spectrum. Enhanced GJ coupling with rotigaptide (n = 10) progressively organized fibrillation in a concentration-dependent manner; increasing FDI (0 nM: 0.53 ± 0.04, 80 nM: 0.78 ± 0.03, P &amp;lt; 0.001), increasing RA-sustained VF time (0 nM: 44 ± 6%, 80 nM: 94 ± 2%, P &amp;lt; 0.001), and stabilized RAs (maximum rotations for an RA; 0 nM: 5.4 ± 0.5, 80 nM: 48.2 ± 12.3, P &amp;lt; 0.001). GJ uncoupling with carbenoxolone progressively disorganized VF; the FDI decreased (0 µM: 0.60 ± 0.05, 50 µM: 0.17 ± 0.03, P &amp;lt; 0.001) and RA-sustained VF time decreased (0 µM: 61 ± 9%, 50 µM: 3 ± 2%, P &amp;lt; 0.001). In CF, VF activity was disorganized and the RA-sustained VF time was the lowest (CF: 27 ± 7% vs. PF: 75 ± 5%, P &amp;lt; 0.001). Global fibrillatory organization measured by FDI was highest in PF (PF: 0.67 ± 0.05 vs. CF: 0.33 ± 0.03, P &amp;lt; 0.001). PF harboured the longest duration and most spatially stable RAs (patchy: 1411 ± 266 ms vs. compact: 354 ± 38 ms, P &amp;lt; 0.001). DiF (n = 11) exhibited an intermediately organized VF pattern, sustained by a combination of multiple-wavelets and short-lived RAs. Conclusion The degree of GJ coupling and pattern of fibrosis influences the mechanism sustaining VF. There is a continuous spectrum of organization in VF, ranging between globally organized fibrillation sustained by stable RAs and disorganized, possibly multiple-wavelet driven fibrillation with no RAs.