tbuckley/cabot-search huggingface dataset:
Vitaxin™, a humanized monoclonal antibody recognizing αvβ3, does not inhibit healing in hamster or rabbit models of cutaneous wounds
Authors: Jon H. Heinrichs, Gizachew Kifle, Richard Woessner, Neil Sparks, Paul Pierce, Steven K. Libutti, Walter Miller
Journal: Cancer Research (2005)

4190  The objective of the study was to evaluate the cardiovascular and pulmonary safety of CuATSM/H2ATSM (NSC-D729307) when administered as a single intravenous bolus dose in beagle dogs. CuATSM is a positron emission tomography (PET) agent for imaging hypoxia, as well as, a potential therapeutic agent. This study was undertaken to determine the safety of Cu-ATSM. The formulation of the imaging drug primarily consists of Cu-ATSM and the parent ligand H2ATSM, which was the formulation used for testing. Doses of 0 (vehicle) and 0.3 mg/kg were administered. Each dose group utilized two male and two female dogs. Clinical observations, body temperatures, body weights, clinical pathology, cardiovascular data (systemic arterial blood pressures, heart rate, ECG waveforms and ECG interval measurements) and pulmonary data (respiratory rate, tidal volume and minute volume) were all evaluated. There were no test article-related changes associated with the clinical observations, body temperatures, body weights or clinical pathology. The hemodynamic parameters, systemic arterial blood pressures (systolic, diastolic, and mean) and heart rate, appeared to increase for the first 10-minute post-dosing period for all animals in both test article and vehicle groups. The 10-minute average pressures increased 10 to 15 mmHg and heart rates increased 15 to 30 BPM as compared to baseline. Pressures returned to near baseline by the second 10-minute interval whereas heart rates returned towards baseline slower. Similar pressure and rate increases in both test article and vehicle groups indicate that a component present in the vehicle was responsible for these elevations. When both sexes were considered, there were no differences between the test article and vehicle groups for first 4.5 hours when the animals were “in-slings” for simultaneous pulmonary determinations. Following the 4.5 hours post-dosing period, animals were returned to their home cages and cardiovascular monitoring continued until 72 hours post-dosing. For the 6 to 72 hour “in-cage” post-dosing period, there were no statistically significant differences between the test article and vehicle groups. No alterations in ECG intervals, rhythm or morphology were noted that could be attributed to the test article. No statistically significant alterations in the pulmonary parameters (respiratory rate, tidal volume, and minute volume) were observed. There were no alterations in the blood pressure, heart rate, ECG or pulmonary parameters that could be attributed to the administration of CuATSM/H2ATSM. The acute blood pressure and heart alterations seen in both test article and vehicle groups, are likely a response to the DMSO component of the formulations (Supported by NCI contract N01-CM-87028 and N01-CM-42200)
Saliva sample as a non-invasive specimen for the diagnosis of coronavirus disease 2019: a cross-sectional study
Authors: E. Pasomsub, S.P. Watcharananan, K. Boonyawat, P. Janchompoo, G. Wongtabtim, W. Suksuwan, S. Sungkanuparph, A. Phuphuakrat
Journal: Clinical Microbiology and Infection (2020)
Empagliflozin improves endothelial and cardiomyocyte function in human heart failure with preserved ejection fraction via reduced pro-inflammatory-oxidative pathways and protein kinase Gα oxidation
Authors: Detmar Kolijn, Steffen Pabel, Yanna Tian, Mária Lódi, Melissa Herwig, Albino Carrizzo, Saltanat Zhazykbayeva, Árpád Kovács, Gábor Á Fülöp, Inês Falcão-Pires, Peter H Reusch, Sophie Van Linthout, Zoltán Papp, Loek van Heerebeek, Carmine Vecchione, Lars S Maier, Michele Ciccarelli, Carsten Tschöpe, Andreas Mügge, Zsolt Bagi, Samuel Sossalla, Nazha Hamdani
Journal: Cardiovascular Research (2020)

Abstract Aims Sodium-glucose-cotransporter-2 inhibitors showed favourable cardiovascular outcomes, but the underlying mechanisms are still elusive. This study investigated the mechanisms of empagliflozin in human and murine heart failure with preserved ejection fraction (HFpEF). Methods and results The acute mechanisms of empagliflozin were investigated in human myocardium from patients with HFpEF and murine ZDF obese rats, which were treated in vivo. As shown with immunoblots and ELISA, empagliflozin significantly suppressed increased levels of ICAM-1, VCAM-1, TNF-α, and IL-6 in human and murine HFpEF myocardium and attenuated pathological oxidative parameters (H2O2, 3-nitrotyrosine, GSH, lipid peroxide) in both cardiomyocyte cytosol and mitochondria in addition to improved endothelial vasorelaxation. In HFpEF, we found higher oxidative stress-dependent activation of eNOS leading to PKGIα oxidation. Interestingly, immunofluorescence imaging and electron microscopy revealed that oxidized PKG1α in HFpEF appeared as dimers/polymers localized to the outer-membrane of the cardiomyocyte. Empagliflozin reduced oxidative stress/eNOS-dependent PKGIα oxidation and polymerization resulting in a higher fraction of PKGIα monomers, which translocated back to the cytosol. Consequently, diminished NO levels, sGC activity, cGMP concentration, and PKGIα activity in HFpEF increased upon empagliflozin leading to improved phosphorylation of myofilament proteins. In skinned HFpEF cardiomyocytes, empagliflozin improved cardiomyocyte stiffness in an anti-oxidative/PKGIα-dependent manner. Monovariate linear regression analysis confirmed the correlation of oxidative stress and PKGIα polymerization with increased cardiomyocyte stiffness and diastolic dysfunction of the HFpEF patients. Conclusion Empagliflozin reduces inflammatory and oxidative stress in HFpEF and thereby improves the NO–sGC–cGMP–cascade and PKGIα activity via reduced PKGIα oxidation and polymerization leading to less pathological cardiomyocyte stiffness.
FDG PET/CT in Anaplastic Lymphoma Kinase–Positive Anaplastic Large Cell Lymphoma
Authors: Meivel Angamuthu, Kanwaljeet Kaur, Madhavi Tripathi, Jagdish Prasad Meena, Rachna Seth, Rakesh Kumar
Journal: Clinical Nuclear Medicine (2020)

Abstract Anaplastic large cell lymphoma (ALCL) is a rare non-Hodgkin’s lymphoma, with rearrangements of the anaplastic lymphoma kinase gene in 60%–85% of systemic cases. We report an 11-year-old boy with ALCL in whom serial FDG PET/CT revealed partial response and complete metabolic response at interim and end of treatment, respectively. However, the patient relapsed within 2 weeks, confirmed by cytology. Because of the inherent aggressive nature of ALCL, possibility of an early relapse should always be kept in mind.
ALGORITHM COMBINING VIRTUAL CHROMOENDOSCOPY FEATURES FOR POLYP CLASSIFICATION
Authors: RM Schreuder, QEW. van der Zander, Roger Fonellà, M Smyl, PHN de With, F van der Sommen, EJ Schoon
Journal: Endoscopy (2020)

Aims Colonoscopy is considered the gold standard for decreasing colorectal cancer incidence and mortality. Visual differentiation between benign and pre-malignant colorectal polyps (CRPs) is an ongoing challenge in clinical endoscopy with accuracies of 71-90% in the Dutch bowel cancer screening program, exposing patients to risks of incorrect optical diagnosis. The PIVI thresholds for CRP-classification are only met in highly selective expert endoscopists. To allow a ‘diagnose-and-leave’ and ‘resect-and-discard’ strategy, optical diagnosis has to be improved. Computer-Aided-Diagnosis systems have been developed to analyze endoscopic images and classifies CRPs by exploiting machine learning algorithms.
The Association of Pipe and Cigar Use With Cotinine Levels, Lung Function, and Airflow Obstruction
Authors: Josanna Rodriguez, Rui Jiang, W. Craig Johnson, Barbara A. MacKenzie, Lewis J. Smith, R. Graham Barr
Journal: Annals of Internal Medicine (2010)

Few studies have examined the association of pipe and cigar smoking with lung function. In this large population-based study, persons who smoked pipes or cigars but not cigarettes were more likely ...
EXPERIENCE WITH CYTOLYT SOLUTION IN ENDOSCOPIC ULTRASOUND-GUIDED TISSUE SAMPLING FOR SPECIMEN PRESERVATION AND EVALUATION
Authors: A López-Serrano, MJ Suárez, P Besó, A Algarra, J Hervás, P Latorre, A Machancoses, E Moreno-Osset
Journal: Endoscopy (2020)

Aims Although Endoscopic Ultrasound (EUS)-guided tissue sampling is widely used, the optimal sampling strategy remains subject of debate. We present our initial experience with liquid based cytology with a special fixative (Cytolyt solution).
ENDOSCOPIC ULTRASOUND FINE NEEDLE ASPIRATION (EUS-FNA) OF A PANCREATIC MASS AFTER ROUX-EN-Y GASTRIC RESECTION - A LAPAROSCOPIC ASSISTED TRANS-JEJUNAL APPROACH
Authors: AL Constantin, E Catanescu, C Copaescu, A Saftoiu
Journal: Endoscopy (2020)

EUS in patients with altered upper GI anatomy represents a real challenge. We present the case of a 48 year male known with gastric resection for peptic ulcer disease with Roux-en-Y anastomosis and cholecystectomy who came to our hospital for jaundice and weight loss. Both CT scan and MRCP showed an expansive process of the head of the pancreas. EUS FNA laparoscopically assisted-trans-jejunal approach was performed and the histopathological exam revealed a mass-forming chronic pancreatitis. In spite of the scarcity of data, this approach has proved to be an appropriate solution in order to put a correct diagnosis
Sodium Etidronate in the Treatment of Paget's Disease of Bone
Authors: M. R. A. Khairi, R. D. Altman, G. P. DeROSA, J. Zimmermann, R. K. Schenk, C. C. Johnston
Journal: Annals of Internal Medicine (2020)

Abstract Subjects (109) with symptomatic Paget's disease of bone were treated with 5, 10, or 20 mg of sodium etidronate (EHDP)/kg body weight day for 6 to 24 months. Significant decreases in serum ...
ENDOSCOPIC INTERNAL DRAINAGE (EID) USING TRANSMURAL DOUBLE-PIG-TAIL STENTS (DPT) IN LEAKS AND SUTURE-LINE DEHISCENCE FOLLOWING UPPER GI TRACT SURGERY: SIMPLE SOLUTION TO A COMPLEX PROBLEM
Authors: JT Tejada, R Sánchez-Ocaña Hernández, FJG Alonso, AY Carbajo López, M De Benito Sanz, CA Martín, KP Muñiz, DP Sánchez, C De La Serna Higuera, M Pérez-Miranda Castillo
Journal: Endoscopy (2020)

Aims Endoscopic management of GI postoperative leaks (POL) is challenging. Therapeutic endoscopy of POL includes intraluminal SEMS and endoscopic vacuum therapy (EVT) using bioactive sponge. Endoscopic internal drainage (EID) with double-pigtail (DPT) could be effective treatment. We report our experience with DPT-EID for leaks or suture-line dehiscence following upper GI tract surgery
Antimicrobial Prophylaxis of Recurrent Urinary Tract Infections
Authors: Walter E. Stamm, George W. Counts, Kenneth F. Wagner, David Martin, David Gregory, Mary McKEVITT, Marvin Turck, King K. Holmes
Journal: Annals of Internal Medicine (2020)

Abstract To study once-daily antimicrobial prophylaxis of urinary tract infections, we gave trimethoprim-sulfamethoxazole (40 mg/200 mg), trimethoprim (100 mg), nitrofurantoin macrocrystals (100 mg...
USING OF ACETIC ACID CHROMOENDOSCOPY FOR THE DIAGNOSIS OF SERRATED COLON POLYPS
Authors: N Ageykina, E Fedorov, P Malkov, N Oleynikova, N Danilova, O Kharlova, Y Korolev
Journal: Endoscopy (2020)

Methods 71 polyps were detected in 57 patients in all parts of the colon: 27(38%) – < 5 mm; 36(50,7%)- 6-10 mm; 8(11,3%) – > 10 mm. The macroscopic type was 0-IIа −50(70,2%), 0-Is −21 (29,5). During colonoscopy, 1.5%-acetic acid, 5 ml, was sprayed onto the identified polyps. Mucosa was observed endoscopically for 2 minutes. Then lesions were removed and sent for pathology examination.
A Case of COVID-19 and <i>Pneumocystis jirovecii</i> Coinfection
Authors: Aravind A. Menon, David D. Berg, Elliot J. Brea, Aaron J. Deutsch, Khameer K. Kidia, Emilia G. Thurber, Sylvie B. Polsky, Tiffany Yeh, Jonathan A. Duskin, Alison M. Holliday, Elizabeth B. Gay, Laura E. Fredenburgh
Journal: American Journal of Respiratory and Critical Care Medicine (2020)

A Case of COVID-19 and Pneumocystis jirovecii CoinfectionTo the Editor:Lymphocytopenia has been identified as a common laboratory finding in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, particularly among those with more severe presentations (1); however, there are limited data on which specific lymphocyte populations may be affected or the clinical sequelae.In this report, we describe the case of a woman with hypoxemic respiratory failure found to have coinfection with SARS-CoV-2 and Pneumocystis jirovecii, a pathogen commonly seen in patients with defects in T-cell immunity.An 83-year-old female nonsmoker presented to our hospital on March 12, 2020, with fevers, malaise, headache, dry cough, and dyspnea.She had a history of mild intermittent asthma, managed with an albuterol inhaler as needed, mitral valve prolapse with moderate to severe mitral regurgitation, and mild to moderate ulcerative colitis, which was well controlled on oral budesonide (3 mg daily and being tapered) as well as maintenance-dose sulfasalazine (1,500 mg twice daily).Her symptoms had started approximately 2 weeks prior to presentation, shortly after travel from Florida to Massachusetts, and had failed to improve with courses of azithromycin and amoxicillin-clavulanate.In the emergency department, she had a fever of 39.3 8 C and oxygen saturation of 86% on room air, which improved to 95% on 5 L/min of supplemental oxygen by nasal cannula.Initial laboratory evaluation revealed leukocytosis and relative lymphocytopenia (absolute lymphocyte count, 1,090 cells/ml) (Table 1).Chest computed tomography was notable for diffuse bilateral ground-glass opacities with patchy bands of atelectasis and small nodular foci of consolidation with a distribution suggestive of a viral pneumonia.Subtle cystic changes were also seen in the affected regions (Figure 1).She was admitted to the medical intensive care unit and placed on strict isolation precautions given concern for community-acquired SARS-CoV-2.She developed worsening tachypnea with a respiratory rate of 40 breaths/min and hypoxia with an oxygen saturation of 80% requiring supplemental oxygen through a nonrebreather mask at a rate of 15 L/min.An arterial blood gas measurement showed a Pa O 2 of 63 mm Hg on 15 L/min of supplemental oxygen.She was intubated for hypoxemic respiratory failure and supported on low VT ventilation according to the Acute Respiratory Distress Syndrome Network
COMBINED ENDOSCOPIC STENTING FOR CONCOMITANT BILIARY AND DUODENAL MALIGNANT STRICTURES: DATA FROM A SERIES IN A SINGLE REFERRAL CENTER
Authors: M Lo Mastro, D Scimeca, F Mocciaro, A Bonaccorso, E Conte, G Russo, R Di Mitri
Journal: Endoscopy (2020)

Aims Endoluminal stent placement is a simple and safe alternative to surgical by-pass in gastric outlet obstruction (GOO) due to advanced gastro-duodenal and bilio-pancreatic cancer. In either biliary or gastro-duodenal malignant obstruction, double biliary and duodenal stenting placement is needed.
ENDOSCOPIC FULL-THICKNESS RESECTION OF EARLY DUODENAL CANCER
Authors: P Pavlov, A Kiryukhin, A Tertychnyy
Journal: Endoscopy (2020)

We present the case of 45-year-old male with early duodenal cancer. Physical and laboratory examinations (including colonoscopy) were unremarkable. The patient underwent endoscopic full-thickness resection of the lesion with the FTRD (full-thickness resection device; Ovesco Endoscopy, Tubingen, Germany) by using a 1-step clip-and-snare technique. Histology confirmed complete (R0) full-thickness resection. There were no complications in postoperative period. The patient was discharged on the third day after surgery.
INCIDENCE OF SEDATION-RELATED COMPLICATIONS AND RISK FACTORS ASSOCIATED WITH NON-ANESTHESIOLOGIST ADMINISTRATION OF SEDATION IN ENDOSCOPIC ULTRASOUND (EUS)- PROSPECTIVE STUDY
Authors: M Razpotnik, S Bota, M Kutilek, G Essler, C Urak, J Weber-Eibel, A Maieron, M Peck-Radosavljevic
Journal: Endoscopy (2020)

Aims To investigate the incidence of adverse events related to non-anesthesiologist sedation during EUS and associated risk factors.
THE PATHOLOGY OF THE PINEAL GLAND.
Authors: J Gruner
Journal: JAMA (1898)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Obstetrics and Gynecology
Authors: Howard G. McQuarrie
Journal: JAMA (1978)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SINGLE-OPERATOR PERORAL CHOLANGIOSCOPY-GUIDED LITHOTRIPSY FOR DIFFICULT BILIARY STONES - A PROSPECTIVE MULTICENTER STUDY
Authors: M Moreira, D Costa, G Alexandrino, J Fernandes, T Araújo, L Lourenço, S Campos, D Horta, Tiago Bana e Costa, Luís Lopes, Jorge Canena
Journal: Endoscopy (2020)

Aims ERCP is the first choice for removal of biliary stones. In difficult stones, advanced therapeutic techniques, such as electrohydraulic lithotripsy (EHL) and laser lithotripsy (LL) have been proposed. Recently, the availability of single-operator cholangioscopy (SOC) turned these techniques more accessible and easier to perform. We sought to evaluate the clinical efficacy and safety of SOC guided-lithotripsy using EHL or LL in patients with complex biliary stones.
SESSILE SERRATED LESIONS IN INFLAMMATORY BOWEL DISEASE - A RETROSPECTIVE STUDY IN A TERTIARY CENTRE
Authors: A Dhillon, A Wilson, N Suzuki, M Choy, S Thomas-Gibson, BP Saunders, A Latchford
Journal: Endoscopy (2020)

Aims Sessile serrated lesions (SSLs) are increasingly recognised at colonoscopy. However, their significance in inflammatory bowel disease (IBD) is unclear. We examined the clinicopathological features and outcome of IBD patients with SSLs.
COLUMNAR-LINED OESOPHAGUS LESS THAN 1 CM ABOVE GASTRO-OESOPHAGEAL JUNCTION AND BARRETT´S OESOPHAGUS: COMPARATIVE MORPHOLOGICAL ANALYSIS
Authors: L Mikhaleva, K Voytkovskaya, E Fedorov, A Shidii-Zakrua
Journal: Endoscopy (2020)

Aims Barrett’s oesophagus (BE) is а premalignant lesion of distal oesophagus. BOBCAT consensus defined BE as any type of columnar metaplasia higher than 1cm above gastro-oesophageal junction (GEJ). Though columnar-lined oesophagus (CLE) less than 1cm above GEJ is not well characterized. The aim of our study was to perform a comparative morphological analysis of BE and CLE less than 1cm above GEJ.
EUS GUIDED RFA OF PNETS: RESULTS OF A PROSPECTIVE STUDY IN 11 PATIENTS
Authors: M Giovannini, F Caillol, JP Ratone, C Pesenti, P Niccoli
Journal: Endoscopy (2020)

Aims Radiofrequency tumor ablation (RFA) is currently used routinely for different primary tumors or metastases. We report our EUS-guided experience of EUS guided RFA for grade 1 PNETs and less than 30 mm in diameter.
OUR NEW EXPERIENCES WITH A ROBOTICCALLY CONTROLLED MAGNETIC CAPSULE ENDOSCOPY SYSTEM TO EVALUATE ESOPHAGEAL AND GASTRIC DISODERS IN PATIENTS REFERRED FOR SMALL BOWEL CAPSULE ENDOSCOPY
Authors: A Finta, BD Lovász, M Szalai, L Oczella, Z Dubravcsik, L Madácsy
Journal: Endoscopy (2020)

Aims: Introduction Capsule endoscopy(CE) is the gold standard examination method of the small bowel. The new robotically controlled magnetic capsule endoscopy (MACE) system has been developed to investigate both stomach and small bowels.
Colonic endoscopic submucosal dissection – increasing attraction with improved traction?
Authors: Andreas Probst
Journal: Endoscopy (2020)

Colonic endoscopic submucosal dissection (ESD) is a challenging procedure involving a learning curve and showing substantial complication rates in unexperienced hands [1]. For this reason, ESD of colonic neoplasms has not become a standard procedure and is still restricted, especially in Western countries, to a few expert centers. Various modifications of the technique have been developed over recent years to overcome technical difficulties, to make ESD easier, and to shorten the learning curve. Key points of the ESD technique are the accessibility of the submucosal layer, which is influenced by the lifting capacity of the submucosal layer (degree of fibrosis), and the traction of the targeted lesion toward the colonic lumen. Consequently, one of the main focuses for modification of the ESD technique has been the development of strategies and devices aimed at improving tissue traction. Modified resection strategies include the optimum use of gravity, tunneling techniques, and pocket creation techniques. In 2002, Oyama et al. first described the clip and line method for esophageal and gastric ESD [2]. After circumferential incision of the target lesion, a hemoclip with a line is fixed at the edge of the lesion, allowing stable access into the submucosal layer. For lesions located in the distal colon and rectum, the double scope technique was introduced by Uraoka et al. in 2007 [3]. The edge of the target lesion is grasped and lifted using a snare or forceps inserted through a second thin endoscope. During subsequent years, several randomized controlled trials were published by Japanese experts investigating different modifications of the clip and line technique (S-O clip method, ring-shaped thread countertraction method, clip and thread method). All studies showed comparable success rates but with significant shortening of the procedure time compared with the standard ESD technique [4]. Nomura et al. described a single-clip traction method in combination with the pocket creation method without using a line [5]. Recently, Jacques et al. presented another innovative technique using two clips and a rubber band to improve countertraction during colonic ESD (DCT-ESD). Compared with the standard ESD technique, a significantly increased en bloc resection rate (95.7 % vs. 76.3 %), R0 resection rate (78.5 % vs. 64.5 %), and speed of dissection (28.2 vs. 16.7 mm2/min) was shown for DCT-ESD in treatment-naïve colorectal lesions [6].