AB0255 CLINICO- BIOLOGICAL PROFILE OF RHEUMATOID ARTHRITIS WITH PERIODONTITIS AND PORPHYROMONAS GINGIVALIS
Authors: Farida Mechid, Houda Hafirassou, Malika Meddad, Samir Salah, Saida Merad, Nawel Blidi, Chafia Makhloufi-Dahou
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> The Periodontitis (PD) is currently recognized as a risk factor of occurrence of the rheumatoid arthritis(RA). The porphyromonas gingivalis (P.gingivalis) figure among the main germs incriminated in the occurrence of the PD. Previous studies have shown that antibodies to P. gingivalis are associated with anti-CCP antibody in patients with RA. However others studies have not demonstrated this association. <h3>Objectives</h3> The aim of this study was to seek for a possible association between clinico-biological parameters of the RA and the presence of the P.gingivalis. <h3>Methods</h3> We conducted a prospective study of 69 patients with early rheumatoid arthritis (≤2 years), naive of biotherapy. Smokers, diabetics, and subjects who received dental care and those who used antibiotics in the previous 6 months were not included. Periodontal status, demographic, clinical activity, and anticyclic citrullinated peptide antibodies (anti-CCP) parameters were determined. The P. gingivalis has been searched in patients with a PD. We sought to investigate an association between Rheumatoid disease activity (DAS28), anticyclic citrullinated peptide antibodies (anti-CCP) and P.gingivalis. <h3>Results</h3> The mean age of our patients was 40.75 ± 12.04, the mean duration of the illness was 14.30±6.76 months (extremes: 1-24 months). ACPA was detected in 88% of patients and the mean titre was 255.57±409.78. 43% of patients have presented a PD. The P.gingivalis has been detected in 59% of PD. The means DAS28 of patient with and without P.gingivalis is respectively 4.40±1.32 and 4.15±1.45, and there was no significant difference (p=0.65). There was also no association observed between anti CCP and the presence of P.gingivalis(the mean titre of anti CCP was 249.47±294.58 with P.gingivalis and 258.67±93.48 without P.gingivalis, p= 0.74). <h3>Conclusion</h3> This study showed that periodontitis is frequent in rheumatoid arthritis. More than half of our patients suffering of periodontitis were infected by porphyromonas gingivalis. Rheumatoid disease activity does not seem to be related to porphyromonas gingivalis. In addition there was no association between anti-CCP antibody and the presence of porphyromonas gingivalis. <h3>References</h3> [1] Johansson L, Sherina N, Kharlamova N, Potempa B, Larsson B, Israelsson L, Potempa J, RantapÄÄ-Dahlqvist S, Lundberg K. Concentration of antibodies against Porphyromonas gingivalis is increased before the onset of symptoms of rheumatoid arthritis. Arthritis Research &amp; Therapy 2016;18: 201. [2] Bello-Gualtero JM, Lafaurie GI, Hoyos LX, et al. Periodontal Disease in Individuals With a Genetic Risk of Developing Arthritis and EarlyRheumatoid Arthritis: A Cross-Sectional Study. J Periodontol. 2016;87(4):346-56. [3] Fisher BA, Cartwright AJ, Quirke AM, de Pablo P, Romaguera D, Panico S, et al. Smoking, Porphyromonas gingivalis and the immune response to citrullinated autoantigens before the clinical onset of rheumatoid arthritis in a Southern European nested case-control study. BMC Musculoskelet Disord. 2015;16:331. [4] Cheng Z, Meade J, Mankia K, Emery P, Devine DA. Periodontal disease and periodontal bacteria as triggers for rheumatoid arthritis. Best Pract Res Clin Rheumatol. 2017;31(1):19-30. <h3>Disclosure of Interests</h3> None declared