tbuckley/cabot-search huggingface dataset:
TCT-198 Final Results of the IC-CATARACT (CATaracts Attributed to Radiation in the CaTh Lab) Study: Lens Changes Associated With Radiation in the Cardiac Catheterization Laboratory
Authors: Judit Karacsonyi, Harilaos Brilakis, J. Roberto Martinez-Parachini, Aris Karatasakis, Barbara Danek, Peter Tajti, Phuong-Khanh Nguyen-Trong, Aya Alame, Iosif Xenogiannis, Michele Roesle, Bavana Rangan, Kenneth Rosenfield, Roxana Mehran, Ehtisham Mahmud, Charles Chambers, Imre Ungi, Subhash Banerjee, Emmanouil Brilakis
Journal: Journal of the American College of Cardiology (2019)
TCT-677 Bare Metal Versus Drug-Eluting Stents for Saphenous Vein Graft Interventions: A Systematic Review and Meta-Analysis
Authors: Qasim Malik, Najam Saqib, Muhammad Siddique Pir, Raza Mian, David Prutzman, Raymond Durkin, Jamshid Shirani, Peter Puleo
Journal: Journal of the American College of Cardiology (2019)
Abstract 18620: Irregular Protrusion Detected by Optical Coherence Tomography is Correlated With the Elevation of Cardiac Enzyme After Metallic Stent Implantation in Patients With Stable Angina
Authors: Tsunenari Soeda, Daisuke Kamon, Yoko Kita, Takuya Isojima, Tomoya Ueda, Satoshi Okayama, Hiroyuki Kawata, Makoto Watanabe, Hiroyuki Okura, Yoshihiko Saito
Journal: Circulation (2017)

Background: Irregular protrusion identified by optical coherence tomography (OCT) after metallic stent implantation is an independent predictor of cardiac events. Methods and Results: We enrolled 1...
TCT-132 Simultaneous Interventional Treatment of Patients With Hypertrophic Obstructive Cardiomyopathy and Coexisting Coronary Artery Disease
Authors: Stanislav Fanta, Vasyl Lazoryshynets, Sviatoslav Kalashnikov, Nataliia Yashchuk, Lidiia Nevmerzhytska, Evgen Aksenov, Liudmyla Dzakhoeva, Vasyl Romanyak
Journal: Journal of the American College of Cardiology (2019)
TCT-568 Effectiveness and Safety of Vacuum-Assisted Thrombectomy Device (AngioVac) for Extraction of Vegetations on Intra-Cardiac Devices and Valves Prior to Device Removal: A Single Center Experience
Authors: Mithun Chakravarthy, David Lasorda, Nitin Bhanot, Krishna Cherukuri, Priyanka Ghosh, Deepika Abbadi, Chinmaya Mareddy
Journal: Journal of the American College of Cardiology (2019)
TCT-169 Early Scaffold Strut Coverage in Ultra-High Molecular Weight Amorphous PLLA Sirolimus-Eluting Bioresorbable Scaffolds: Impact of Strut Thickness Assessed in Normal Porcine Coronary Arteries
Authors: Pawel Gasior, Yanping Cheng, Jenn McGregor, Gerard Conditt, Juan Granada, Grzegorz Kaluza
Journal: Journal of the American College of Cardiology (2019)
Boosting Gamma Delta T Cells-Mediated ADCC By PD-1 Blockade in Follicular Lymphoma
Authors: Christine Bezombes, Cédric Rossi, Pauline Gravelle, Julie Bordenave, Emilie Decaup, Mary Poupot, Marie Tosolini, Don-Marc Franchini, Camille Laurent, Renaud Morin, Jean-Michel Lagarde, Loic Ysebaert, Ariel Savina, Christian Klein, Patricia Perez-Galan, Jean-Jacques Fournié
Journal: Blood (2018)
Tips and tricks for avoiding the dreaded intramural esophageal dissection during peroral endoscopic myotomy: recognize!
Authors: Dennis Yang, Peter V. Draganov
Journal: Endoscopy (2019)

See also:Intramural esophageal dissection during peroral endoscopic myotomyEndoscopy 2019; 51(07): E197-E198DOI: 10.1055/a-0875-3869See also:Reply to Yang et al.Endoscopy 2019; 51(10): 997-997DOI: 10.1055/a-0977-3263
An outbreak of viral gastroenteritis linked to municipal water supply, Lombardy, Italy, June 2009
Authors: C Scarcella, S Carasi, F Cadoria, L Macchi, A Pavan, M Salamana, G L Alborali, M N Losio, P Boni, A Lavazza, T Seyler
Journal: Eurosurveillance (2009)

We report an outbreak of viral gastroenteritis linked to municipal drinking water in a town in northern Italy in June 2009. Over one month we identified 299 probable cases of whom 30 were confirmed for at least one of the following viruses: norovirus, rotavirus, enterovirus or astrovirus. Water samples and filters from the water system also tested positive for norovirus and enterovirus. Control measures included treating the water system with chlorine dioxide and filters with peracetic acid, while providing temporary alternative sources of drinking water to the population.
Tolerance to Selenoprotein Loss Differs between Human and Mouse
Authors: Didac Santesmasses, Marco Mariotti, Vadim N Gladyshev
Journal: Molecular Biology and Evolution (2019)

Mouse has emerged as the most common model organism in biomedicine. Here, we analyzed the tolerance to the loss-of-function (LoF) of selenoprotein genes, estimated from mouse knockouts and the frequency of LoF variants in humans. We found not only a general correspondence in tolerance (e.g., GPX1, GPX2) and intolerance (TXNRD1, SELENOT) to gene LoF between humans and mice but also important differences. Notably, humans are intolerant to the loss of iodothyronine deiodinases, whereas their deletion in mice leads to mild phenotypes, and this is consistent with phenotype differences in selenocysteine machinery loss between these species. In contrast, loss of TXNRD2 and GPX4 is lethal in mice but may be tolerated in humans. We further identified the first human SELENOP variants coding for proteins varying in selenocysteine content. Finally, our analyses suggested that premature termination codons in selenoprotein genes trigger nonsense-mediated decay, but do this inefficiently when UGA codon is gained. Overall, our study highlights differences in the physiological importance of selenoproteins between human and mouse.
EBGene trial: patient preselection outcomes for the European GENEGRAFT <i>ex vivo</i> phase I/II gene therapy trial for recessive dystrophic epidermolysis bullosa
Authors: S. Gaucher, S.M. Lwin, M. Titeux, A. Abdul‐Wahab, N. Pironon, A. Izmiryan, S. Miskinyte, C. Ganier, S. Duchatelet, J.E. Mellerio, E. Bourrat, J.A. McGrath, A. Hovnanian
Journal: British Journal of Dermatology (2019)
Lefamulin—A New Antibiotic for Community-Acquired Pneumonia
Authors: Preeti N. Malani
Journal: JAMA (2019)

Elizabeth Alexander, MD, MSc; Lisa Goldberg, MS; Anita F. Das, PhD; Gregory J. Moran, MD; Christian Sandrock, MD; Leanne B. Gasink, MD; Patricia Spera, PhD; Carolyn Sweeney, BS; Susanne Paukner, PhD; Wolfgang W. Wicha, MSc; Steven P. Gelone, PharmD; Jennifer Schranz, MD
TCT-664 Overlapping Drug-Eluting Stent Increases Definite Stent Thrombosis and Revascularization: Results From 15,561 Patients in the AUTHENTIC Study
Authors: Xiang Chen, Xiaofei Gao, Jing Kan, Rajiv Shrestha, Leng Han, Shu Lu, Nailiang Tian, Song Lin, Liang Chen, Zhen Ge, Bill Gogas, Junjie Zhang, Shao-Liang Chen
Journal: Journal of the American College of Cardiology (2019)
TCT-751 Prevalence and Severity of Prosthesis-Patient Mismatch After Transcatheter Aortic Valve Replacement Defined by Computed Tomography vs. Transthoracic Echocardiography
Authors: Miho Fukui, Liang Tang, John Lesser, Hiroki Niikura, Mariana Nunes, Marcus Burns, Lynelle Schneider, B. Kelly Han, Santiago Garcia, Mario Goessl, Paul Sorajja, Joao Cavalcante
Journal: Journal of the American College of Cardiology (2019)
Today's Special on the Anticancer Menu: Immunomodulation by Antifolates
Authors: Aitziber Buque, Lorenzo Galluzzi, Noelia Casares
Journal: Clinical Cancer Research (2019)

Pemetrexed is widely employed for the clinical management of mesothelioma and non-small cell lung carcinoma, largely based on its ability to curtail folate metabolism in highly proliferating cells. Recent preclinical findings suggest that the therapeutic efficacy of pemetrexed may involve an unsuspected immunologic component.See related article by Schaer et al., p. 7175.
Abstract 36: Application of “Omics” to Assess the Inter Passage Variability in the Immunoprivilege of Mesenchymal Stem Cells
Authors: Glen Lester Sequiera, Niketa Sareen, Vikram Sharma, Rakesh Chaudhary, Ejlal Abu Al-Rub, Meenal Moudgil, Amir Ravandi, Sanjiv Dhingra
Journal: Circulation Research (2016)

Introduction: Bone marrow derived allogeneic mesenchymal stem cells (MSCs) from young healthy donors are immunoprivileged. However recent data from preclinical and clinical studies indicate that allogeneic MSCs provoke immune response in the recipient heart and are rejected after transplantation. We recently observed that stem cell surface oxidized phospholipids (ox-PCs) modulate allogeneic immune cell response. In most of the allogeneic MSCs based clinical trials in cardiac patients, cells from a single donor were expanded in cultures and transplanted. However, the effect of increase in the passage number on stem cell membrane lipidome and its association with immunogenicity of MSCs has not been investigated yet, the present study was carried out to address this Methods: MSCs isolated from Wistar rats were allowed to grow for different passages namely Passage 3, 5 and 7 (P 3, 5 and 7). The immunoprivilege of MSCs was assessed by mixed leukocyte reaction assay. Briefly, MSCs were co-cultured with mixed leukocytes derived from SD rats for 72 h. Leukocyte mediated cytotoxicity (lactate dehydrogenase release) and apoptosis (Bax/Bcl-xl ratio) in MSCs was assessed after the co-culture. Furthermore, MSCs at different passages were analyzed by LC/MS/MS -“lipidomic platform” for cell surface ox-PCs levels and “proteomic platform” for intracellular proteins. Results and conclusions: We observed a decrease in lymphocyte mediated cytotoxicity and Bax/ Bcl-xl ratio in MSCs at P5 and7 compared to P3. The lipidome analysis showed that the levels of immunomodulatory ox-PCs increased in MSCs at P5 and P7. Inhibition of ox-PCs was associated with the loss of immunoprivilege of MSCs. To find if the ox-PCs were acting in tandem with downstream intracellular protein alterations, we performed proteome analysis. There were significant changes in proteins related to intracellular immune response, lipid metabolism and mitochondrial dynamics. In depth analysis of the ‘omics’ data is now going on to pinpoint associations between cell surface ox-PCs and the candidate intracellular proteins involved in immune modulation. To the best of our knowledge this is the first study integrating membrane lipidomic with intracellular proteins to assess immunogenicity of MSCs.
TCT-502 1-Year Outcomes of Supersaturated Oxygen Therapy in Acute Anterior Myocardial Infarction: The IC-HOT Study
Authors: Shmuel Chen, Shukri David, Zubair Khan, Nainesh Patel, D. Christopher Metzger, Frances Wood, Hal Wasserman, Amir Lotfi, Ivan Hanson, Simon Dixon, Thomas Lalonde, Philippe Genereux, M. Ozgu Ozan, Akiko Maehara, Gregg Stone
Journal: Journal of the American College of Cardiology (2019)
Incidences of Severe Hypoglycemia and Diabetic Ketoacidosis and Prevalence of Microvascular Complications Stratified by Age and Glycemic Control in U.S. Adult Patients With Type 1 Diabetes: A Real-World Study
Authors: Jeremy H. Pettus, Fang Liz Zhou, Leah Shepherd, Ronald Preblick, Phillip R. Hunt, Sachin Paranjape, Kellee M. Miller, Steven V. Edelman
Journal: Diabetes Care (2019)

OBJECTIVE To assess the burden of disease for adults with type 1 diabetes in a U.S. electronic health record database by evaluating acute and microvascular complications stratified by age and glycemic control. RESEARCH DESIGN AND METHODS This is a retrospective observational study of adults with type 1 diabetes (1 July 2014–30 June 2016) classified using a validated algorithm, with disease duration ≥24 months and, during a 12-month baseline period, not pregnant and having one or more insulin prescriptions and one or more HbA1c measurements. Demographic characteristics, acute complications (severe hypoglycemia [SH], diabetic ketoacidosis [DKA]), and microvascular complications (neuropathy, nephropathy, retinopathy) were stratified by age (18–25, 26–49, 50–64, ≥65 years) and glycemic control (HbA1c &amp;lt;7%, 7% to &amp;lt;9%, ≥9%). RESULTS Of 31,430 patients, ∼20% had HbA1c &amp;lt;7%. Older patients had lower HbA1c values than younger patients (P &amp;lt; 0.001). Patients with poor glycemic control had the highest annual incidence of SH (4.2%, 4.0%, and 8.3%) and DKA (1.3%, 2.8%, and 15.8%) for HbA1c &amp;lt;7%, 7% to &amp;lt;9%, and ≥9% cohorts, respectively (both P &amp;lt; 0.001), and a higher prevalence of neuropathy and nephropathy (both P &amp;lt; 0.001). CONCLUSIONS For adults with type 1 diabetes, glycemic control appears worse than previously estimated. Rates of all complications increased with increasing HbA1c. Compared with HbA1c &amp;lt;7%, HbA1c ≥9% was associated with twofold and 12-fold higher incidences of SH and DKA, respectively. Younger adults had more pronounced higher risks of SH and DKA associated with poor glycemic control than older adults.
TCT-423 Periprocedural Myocardial Infarction Is Associated With Mortality in Stable Angina Pectoris Patients Undergoing Elective Coronary Intervention
Authors: Mohamad Soud, Alexandre Hideo-Kajita, Gavin Ho, Omar Yacob, Sabin Parajuli, Gauravpal S. Gill, Ron Waksman, Eugene McFadden, Hector Garcia-Garcia
Journal: Journal of the American College of Cardiology (2019)
TCT-166 Optimal Vessel Sizing for the Bioresorbable Scaffold Implantation and the Incidence of Scaffold Thrombosis: Insights From the COMPARE-ABSORB Trial
Authors: Chun-Chin Chang, Yoshinobu Onuma, Bernard Chevalier, Nick West, Tommaso Gori, Emanuele Barbato, Giuseppe Tarantini, Viktor Kocka, Stephan Achenbach, Dariusz Dudek, Javier Escaned, Mohamed Abdel-Wahab, Giovanni Esposito, Jan Tijssen, Marie-Claude Morice, Pieter Smits, Robert-Jan Van Geuns
Journal: Journal of the American College of Cardiology (2019)
TCT-363 In-Hospital Outcomes of Intracoronary Imaging-Guided Versus Angiographic-Guided Percutaneous Coronary Intervention
Authors: Fahed Darmoch, Yasser Al-Khadra, Homam Moussa Pacha, Mohamad Soud, M. Chadi Alraies
Journal: Journal of the American College of Cardiology (2019)
Mapping and Ablation of Ventricular Fibrillation Associated With Early Repolarization Syndrome
Authors: Koonlawee Nademanee, Michel Haissaguerre, Mélèze Hocini, Akihiko Nogami, Ghassen Cheniti, Josselin Duchateau, Elijah R. Behr, Magdi Saba, Ryan Bokan, Qing Lou, Montawatt Amnueypol, Ruben Coronel, Apichai Khongphatthanayothin, Gumpanart Veerakul
Journal: Circulation (2019)

We conducted a multicenter study to evaluate mapping and ablation of ventricular fibrillation (VF) substrates or VF triggers in early repolarization syndromes (ERS) or J-wave syndrome (JWS).We studied 52 patients with ERS (4 women; median age, 35 years) with recurrent VF episodes. Body surface electrocardiographic imaging and endocardial and epicardial electroanatomical mapping of both ventricles were performed during sinus rhythm and VF for localization of triggers, substrates, and drivers. Ablations were performed on VF substrates, defined as areas that had late depolarization abnormalities characterized by low-voltage fractionated late potentials, and VF triggers.Fifty-one of the 52 patients had detailed mapping that revealed 2 phenotypes: group 1 had late depolarization abnormalities predominantly at the right ventricular (RV) epicardium (n=40), and group 2 had no depolarization abnormalities (n=11). Group 1 can be subcategorized into 2 groups: Group 1A included 33 patients with ERS with Brugada electrocardiographic pattern, and group 1B included 7 patients with ERS without Brugada electrocardiographic pattern. Late depolarization areas colocalize with VF driver areas. The anterior RV outflow tract/RV epicardium and the RV inferior epicardium are the major substrate sites for group 1. The Purkinje network is the leading underlying VF trigger in group 2 that had no substrates. Ablations were performed in 43 patients: 31 and 5 group 1 patients had only VF substrate ablation and VF substrates plus VF trigger, respectively (mean, 1.4±0.6 sessions); 6 group 2 patients and 1 patient without group classification had only Purkinje VF trigger ablation (mean, 1.2±0.4 sessions). Ablations were successful in reducing VF recurrences (P<0.0001). After follow-up of 31±26 months, 39 (91%) had no VF recurrences.There are 2 phenotypes of ERS/J-wave syndrome: one with late depolarization abnormality as the underlying mechanism of high-amplitude J-wave elevation that predominantly resides in the RV outflow tract and RV inferolateral epicardium, serving as an excellent target for ablation, and the other with pure ERS devoid of VF substrates but with VF triggers that are associated with Purkinje sites. Ablation is effective in treating symptomatic patients with ERS/J-wave syndrome with frequent VF episodes.
TCT-42 Polymer-Free Drug-Coated Versus Bare-Metal Coronary Stents in Patients Undergoing Noncardiac Surgery: A Subgroup Analysis of the LEADERS FREE Trial
Authors: Gert Richardt, Mohammad Abdelghani, Ralph Toelg, Marie-Claude Morice, Samuel Copt, Hans-Peter Stoll, Philip Urban
Journal: Journal of the American College of Cardiology (2019)
TCT-684 Treatment Strategies in Patients With Stable Obstructive Coronary Artery Disease and Severe Aortic Valve Stenosis Who Underwent TAVR
Authors: Mahmoud Ali, Marc Atzenhoefer, Payal Sharma, Khalil Odeh, Ana Perez Moreno, Renuka Jain, Suhail Q. Allaqaband, Tanvir Bajwa, Louie Kostopoulos
Journal: Journal of the American College of Cardiology (2019)
TCT-388 Very Long-Term (&gt;10 Years) Safety and Effectiveness of Drug-Eluting or Bare-Metal Stents for Unprotected Left Main Coronary Disease
Authors: Hanbit Park, Ju Hyeon Kim, Junho Hyun, Yeongjin Jeong, Yujin Yang, KyungJin Choe, Sangwoo Park, Sang-Cheol Cho, Euihong Ko, Do-Yoon Kang, Pil Hyung Lee, Jung-Min Ahn, Duk-Woo Park, Seung-Whan Lee, Seong-Wook Park, Seung-Jung Park
Journal: Journal of the American College of Cardiology (2019)
Generation of hepatic spheroids using human hepatocyte-derived liver progenitor-like cells for hepatotoxicity screening
Authors: Zhenyu Wang, Weijian Li, Hongshu Jing, Ming Ding, Gongbo Fu, Tianjie Yuan, Weijian Huang, Mengjun Dai, Dan Tang, Min Zeng, Yi Chen, Hongdan Zhang, Xuejing Zhu, Yuan Peng, Qigen Li, Wei-Feng Yu, He-Xin Yan, Bo Zhai
Journal: Theranostics (2019)

Rationale: The idiosyncratic drug-induced liver injury (iDILI) is a major cause of acute liver injury and a key challenge in late-stage drug development. Individual heterogeneity is considered to be an essential factor of iDILI. However, few in vitro model can predict heterogeneity in iDILI. We have previously shown that mouse and human hepatocytes can be converted to expandable liver progenitor-like cells in vitro (HepLPCs). However, the limited proliferation potential of human HepLPCs confines its industrial application. Here, we reported the generation of a novel hepatocyte model not only to provide unlimited cell sources for human hepatocytes but also to establish a tool for studying iDILI in vitro. Methods: Human primary hepatocytes were isolated by modified two-step perfusion technique. The chemical reprogramming culture condition together with gene-transfer were then used to generate the immortalized HepLPC cell lines (iHepLPCs). Growth curve, doubling time, and karyotype were analyzed to evaluate the proliferation characteristics of iHepLPCs. Modified Hepatocyte Maturation Medium and 3D spheroid culture were applied to re-differentiate iHepLPCs. Results: iHepLPCs exhibited efficient expansion for at least 40 population doublings, with a stable proliferative ability. They could easily differentiate back into metabolically functional hepatocytes in vitro within 10 days. Furthermore, under three-dimensional culture conditions, the formed hepatic spheroids showed multiple liver functions and toxicity profiles close to those of primary human hepatocytes. Importantly, we established a hepatocyte bank by generating a specific number of such cell lines. Screening for population heterogeneity allowed us to analyze the in vitro heterogeneous responses to hepatotoxicity induced by molecular targeted drugs. Conclusions: In light of the proliferative capacity and the heterogeneity they represented, these iHepLPCs cell lines may offer assistance in studying xenobiotic metabolism as well as liver diseases in vitro.
TCT-264 Clinical Outcome Post–Sirolimus-Coated Balloon Angioplasty in Patients With De Novo Lesions Located in Small-Vessel Arteries (≤2.75 mm): 2-Year Results From a Prospective Study
Authors: Bernardo Cortese, Sameer Dani, Keyur Parikh, Prathrap Kumar, Ranjan Shetty, Jagdish Hiremath, Dinesh Shah
Journal: Journal of the American College of Cardiology (2019)
TCT-640 Clinical Outcomes After Percutaneous Coronary Intervention in Very Old Patients With Acute Coronary Syndrome: An Analysis From Interventional Cardiology Research In-Cooperation Society-Drug-Eluting Stents (IRIS-DES) Registry
Authors: Tae Oh Kim, Sangwoo Park, KyungJin Choe, Yujin Yang, Junghoon Lee, Yeongjin Jeong, Junho Hyun, Hanbit Park, Sang-Cheol Cho, Euihong Ko, Do-Yoon Kang, Pil Hyung Lee, Jung-Min Ahn, Duk-Woo Park, Seung-Whan Lee, Seong-Wook Park, Seung-Jung Park
Journal: Journal of the American College of Cardiology (2019)
TCT-670 Worse Prognosis in Old Thrombi Related Large Vessel Occlusion Stroke
Authors: Martijn Meuwissen, Tim van de Hoef, Robbert de Winter, Allard van der Wal, Kartika Pertiwi, Thijs de Jong, Ruud Aarts, Rob Versteylen, Maarten Sturm, Farshad Imani, Peter Den Heijer, Alexander Ijsselmuiden
Journal: Journal of the American College of Cardiology (2019)
Analysis of State-Level Drug Pricing Transparency Laws in the United States
Authors: Martha S. Ryan, Neeraj Sood
Journal: JAMA Network Open (2019)

Increasing drug prices strain the budgets of consumers and public payers, including Medicaid. Faced with an opaque drug supply chain, few people outside of the pharmaceutical industry know which supply chain participants are making excess profits and where to target policy solutions.1,2 Some states have responded by passing laws to increase drug price transparency in the supply chain.3 In this study, we analyzed state drug price transparency laws to assess their potential to improve transparency in the drug supply system. Prior research has focused on state laws requiring manufacturers to report research and development expenditures and efforts to control costs through drug importation or manufacturer price controls.3,4 To our knowledge, this is the first study to focus on state laws to improve drug price transparency across the supply chain.
TCT-204 Evaluation and Validation of the Beckman-Coulter ACCESS High Sensitivity Troponin I Assay using a Novel Single Cut-Off Strategy for an Early Rule Out Acute Coronary Syndrome Protocol (ACS-ERP) in a Real-World Emergency Department Population
Authors: Kalaivani Mahadevan, Chloe Walster, Georgina Latcham, Amy Carolin, Alex Hobson
Journal: Journal of the American College of Cardiology (2019)
Efficacy and safety of dupilumab in Japanese adults with moderate‐to‐severe atopic dermatitis: a subanalysis of three clinical trials
Authors: N. Katoh, Y. Kataoka, H. Saeki, M. Hide, K. Kabashima, T. Etoh, A. Igarashi, S. Imafuku, M. Kawashima, M. Ohtsuki, H. Fujita, K. Arima, H. Takagi, Z. Chen, B. Shumel, M. Ardeleanu
Journal: British Journal of Dermatology (2019)

BackgroundDupilumab, a human monoclonal antibody, blocks the shared receptor unit for interleukin‐4 and interleukin‐13. International phase II and III studies have evaluated the efficacy and safety of dupilumab in adults with moderate‐to‐severe atopic dermatitis (AD), but the effects of dupilumab in Japanese patients have not been reported.
TCT-31 Use of Iso-Osmolar Contrast Media in High-AKI-Risk Patients Undergoing Peripheral Revascularization Procedures Is Associated With Lower Incidence of Major Adverse Renal or Cardiac Events (MARCE)
Authors: Anand Prasad, Amit Amin, Michael Ryan, Candace Gunnarsson, Emmanouil Brilakis
Journal: Journal of the American College of Cardiology (2019)