tbuckley/cabot-search huggingface dataset:
1380P Description of the clinical characteristics and survival in patients with metastatic NSCLC in the Spanish population: An analysis of the thoracic tumours registry (RTT study)
Authors: F. Franco, E. Carcereny Costa, D. Rodriguez-Abreu, R. Lopez Castro, M. Cobo Dols, M. Guirado, B. Massuti Sureda, A.L. Ortega Granados, R. Garcia Campelo, O. Juan-Vidal, A. Blasco Cordellat, E. del Barco Morillo, R. Bernabe Caro, J. Bosch-Barrera, J.L. Gonzalez-Larriba, M.A. Sala Gonzalez, J.M. Trigo Perez, J.M. Oramas Rodriguez, A. Estival, M. Provencio Pulla
Journal: Annals of Oncology (2020)
1517P Integration of the palliative care team with oncologic care in a tertiary cancer center in Brazil: Perception of patients and healthcare professionals after 1 year of integration
Authors: T.V. Guimarães, A.G. Campolina, F.N. Costa, M.H.C. Sponton, M.D.P.E. Diz, M.R. Silva, T. Chiba
Journal: Annals of Oncology (2020)
Metabolic Imaging Detects Resistance to PI3Kα Inhibition Mediated by Persistent FOXM1 Expression in ER+ Breast Cancer
Authors: Susana Ros, Alan J. Wright, Paula D'Santos, De-en Hu, Richard L. Hesketh, Yaniv Lubling, Dimitra Georgopoulou, Giulia Lerda, Dominique-Laurent Couturier, Pedram Razavi, Rapahel Pelossof, Ankita S. Batra, Elizabeth Mannion, David Y. Lewis, Alistair Martin, Richard D. Baird, Mafalda Oliveira, Leonora W. de Boo, Sabine C. Linn, Maurizio Scaltriti, Oscar M. Rueda, Alejandra Bruna, Carlos Caldas, Kevin M. Brindle
Journal: Cancer Cell (2020)

PIK3CA, encoding the PI3Kα isoform, is the most frequently mutated oncogene in estrogen receptor (ER)-positive breast cancer. Isoform-selective PI3K inhibitors are used clinically but intrinsic and acquired resistance limits their utility. Improved selection of patients that will benefit from these drugs requires predictive biomarkers. We show here that persistent FOXM1 expression following drug treatment is a biomarker of resistance to PI3Kα inhibition in ER
1443P Modified FOLFOX versus modified FOLFOX plus nivolumab and ipilimumab in patients with previously untreated advanced or metastatic adenocarcinoma of the stomach or gastroesophageal junction – Safety Results from AIO-STO-0417: A randomized phase II trial of the German Gastric Group of the AIO
Authors: C. Pauligk, T.O. Götze, P.C. Thuss-Patience, J. Riera-Knorrenschild, E. Goekkurt, T.J. Ettrich, D. Pink, U. Lindig, K.B. Luley, T. Dechow, M. Bitzer, S. Angermeier, N. Homann, F. Kullmann, G. Schuch, C. Bolling, S. Junge, R.D. Hofheinz, S. Lorenzen, S-E. Al-Batran
Journal: Annals of Oncology (2020)
362O Perifocal edema volume correlates with density of tumour-infiltrating cytotoxic T cells in newly diagnosed glioblastoma
Authors: M.J. Mair, K. Häller, G.J. Kührer, K. Feldmann, B. Kiesel, A. Wöhrer, G. Widhalm, J. Furtner-Srajer, M. Preusser, A.S. Berghoff
Journal: Annals of Oncology (2020)
1330P Discontinuation of ICIs above 18 months of treatment in real-life patients with NSCLC: A multicentric retrospective study
Authors: G. Bilger, N. Girard, E. Giroux-Leprieur, F. Giraud, S. Friard, C. Decroisette, M. Giaj Levra, A. Livartowski, M.A. Massiani
Journal: Annals of Oncology (2020)
The Perth Gender Picture (PGP): Young people’s feedback about acceptability and usefulness of a new pictorial and narrative approach to gender identity assessment and exploration
Authors: Julia K. Moore, Cati S. Thomas, Hans-willem van Hall, Penelope Strauss, Liz A. Saunders, Melanie Harry, Simone Mahfouda, Sahra J. Lawrence, Florian D. Zepf, Ashleigh Lin
Journal: International Journal of Transgender Health (2020)

A number of psychological assessment tools have been developed to describe various dimensions of gender. Some of these tools are restricted to a binary gender concept and are inflexible in reflecting how a young person's gender may change and develop over time. Most are text questionnaires which require a good level of literacy.This study aimed to evaluate a newly developed pictorial tool that facilitates a conversation about gender between a child or adolescent (aged 11-18) and their clinician, enabling a diverse understanding and expression of gender identity.The Perth Gender Picture (PGP) was co-created between clinicians and young clients between 2016 and 2018. In 2018, the measure was evaluated through a pilot study at the Gender Diversity Service at Perth Children's Hospital in Western Australia. After use of the PGP during a clinical consultation, clients were invited to fill in a feedback questionnaire about their experience of its use. Clinicians participated in unstructured interviews to give their feedback.Most participants rated the PGP as easy to understand, acceptable and useful, and many stated that they found gender easier to describe with the picture rather than words. The results show positive uptake from clients, demonstrating feasible implementation with gender diverse young people.This evaluation positions the PGP as a useful tool to facilitate conversations about gender identity between gender diverse children and adolescents and their clinicians, in a nonjudgmental and playful manner. It is well-suited to young people who may have limited literacy or difficulty with complex language. The PGP has potential for use in other age groups and non-clinical contexts.
690TiP A phase III, randomized, double-blind trial of nivolumab or placebo combined with docetaxel for metastatic castration-resistant prostate cancer (mCRPC; CheckMate 7DX)
Authors: C.G. Drake, F. Saad, W.R. Clark, M. Ciprotti, B. Sharkey, S.K. Subudhi, K. Fizazi
Journal: Annals of Oncology (2020)
422P Age and pathological complete response after neoadjuvant chemoradiation (CRT) with or without oxaliplatin in locally advanced rectal cancer (LARC): Individual patient data (IPD) meta-analysis of three randomised trials (RTs)
Authors: E. Fontana, C. Zichi, E.C. Smyth, M. Mauer, C. Rödel, E. Fokas, R.D. Hofheinz, D. Arnold, H.J.E-V. Schmoll, E. Van Cutsem, K.M. Haustermans, A. Stein, J-P. Gérard, T. Conroy, C. Jouffroy, M. Moehler, F. Lordick, I. Ben-Aharon, M. Di Maio
Journal: Annals of Oncology (2020)
Endoscopic ultrasound-guided jejuno-jejunal anastomosis for malignant outlet obstruction after total gastrectomy
Authors: Andrea Lisotti, Claudio Calvanese, Martina Valgiusti, Igor Bacchilega, Pietro Fusaroli
Journal: Endoscopy (2020)

Endoscopic ultrasound (EUS)-guided gastrointestinal anastomosis with a lumen-apposing metal stent (LAMS) is an effective alternative to intraluminal stenting for upper gastrointestinal obstruction [1] [2]. Recently, EUS-guided jejuno-jejunal anastomosis (EUS-JJA) has been reported for adhesive obstruction after gastric bypass and afferent loop syndrome [3] [4] [5].
559P Phase Ib study of CC-90011 plus etoposide and cisplatin (EP) in patients with first-line extensive-stage (ES) small cell lung cancer (SCLC)
Authors: L. Paz-Ares, O. Juan-Vidal, E. Carcereny, L. Greillier, A. Navarro, J. Bennouna, A. Santoro, R. Berardi, B. Besse, S. Salvagni, H. Gonzalez, J. de Alvaro, J. Parra-Palau, T. Sánchez-Pérez, I. Aronchik, E. Filvaroff, M. Lamba, Z. Nikolova, S. Ponce
Journal: Annals of Oncology (2020)
78TiP KEYNOTE-966 trial in progress: Pembrolizumab plus gemcitabine and cisplatin for advanced biliary tract cancer
Authors: J.W. Valle, R.K. Kelley, J. Furuse, J. Edeline, R.S. Finn, Z. Ren, S-C. Su, U. Malhotra, A.B. Siegel, A. Vogel
Journal: Annals of Oncology (2020)
Rabies in a Dog Imported from Egypt — Kansas, 2019
Authors: Chelsea Raybern, Allison Zaldivar, Sheri Tubach, Farah S. Ahmed, Susan Moore, Caitlin Kintner, Ryan M. Wallace, Anna M. Mandra, Kendra Stauffer, Rene Edgar Condori, Ingrid Garrison
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

Although canine rabies virus variant (CRVV) was successfully eliminated from the United States after approximately 6 decades of vaccination campaigns, licensing requirements, and stray animal control, dogs remain the principal source of human rabies infections worldwide. A rabies vaccination certificate is required for dogs entering the United States from approximately 100 countries with endemic CRVV, including Egypt (1). On February 25, 2019, rabies was diagnosed in a dog imported from Egypt, representing the third canine rabies case imported from Egypt in 4 years (2,3). This dog and 25 others were imported by a pet rescue organization in the Kansas City metropolitan area on January 29. Upon entry into the United States, all 26 dogs had certificates of veterinary inspection, rabies vaccination certificates, and documentation of serologic conversion from a government-affiliated rabies laboratory in Egypt. CDC confirmed that the dog was infected with a CRVV that circulates in Egypt, underscoring the continued risk for CRVV reintroduction and concern regarding the legitimacy of vaccine documentation of dogs imported from countries considered at high risk for CRVV. Vaccination documentation of dogs imported from these countries should be critically evaluated before entry into the United States is permitted, and public health should be consulted upon suspicion of questionable documents.
1137P Incidence and time course of adverse events (AEs) with atezolizumab (A) in combination with vemurafenib (V) and cobimetinib (C) in the phase III IMspire150 study
Authors: K. Lewis, C. Robert, P.A. Ascierto, R. Munhoz, G. Liszkay, L. de la Cruz Merino, J. Olah, P. Queirolo, J. Mackiewicz, H. Li, Q. Zhu, E. McKenna, V. McNally, R. Gutzmer, G. McArthur
Journal: Annals of Oncology (2020)
1145P Metabolic activity of liver metastases may predict survival in patients with metastatic uveal melanoma
Authors: L.P. del Carpio Huerta, M. Algarra, A. Sabaté Llobera, A. Rodríguez-Vida, S. Ruiz, D. Leiva, D. Lorenzo, V. Navarro, C. Gutiérrez, J.M. Caminal, J.M. Piulats Rodriguez
Journal: Annals of Oncology (2020)
Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer’s disease
Authors: Xiaoqi Wang, Weijie Huang, Li Su, Yue Xing, Frank Jessen, Yu Sun, Ni Shu, Ying Han
Journal: Molecular Neurodegeneration (2020)

Subjective cognitive decline (SCD) is regarded as the first clinical manifestation in the Alzheimer's disease (AD) continuum. Investigating populations with SCD is important for understanding the early pathological mechanisms of AD and identifying SCD-related biomarkers, which are critical for the early detection of AD. With the advent of advanced neuroimaging techniques, such as positron emission tomography (PET) and magnetic resonance imaging (MRI), accumulating evidence has revealed structural and functional brain alterations related to the symptoms of SCD. In this review, we summarize the main imaging features and key findings regarding SCD related to AD, from local and regional data to connectivity-based imaging measures, with the aim of delineating a multimodal imaging signature of SCD due to AD. Additionally, the interaction of SCD with other risk factors for dementia due to AD, such as age and the Apolipoprotein E (ApoE) ɛ4 status, has also been described. Finally, the possible explanations for the inconsistent and heterogeneous neuroimaging findings observed in individuals with SCD are discussed, along with future directions. Overall, the literature reveals a preferential vulnerability of AD signature regions in SCD in the context of AD, supporting the notion that individuals with SCD share a similar pattern of brain alterations with patients with mild cognitive impairment (MCI) and dementia due to AD. We conclude that these neuroimaging techniques, particularly multimodal neuroimaging techniques, have great potential for identifying the underlying pathological alterations associated with SCD. More longitudinal studies with larger sample sizes combined with more advanced imaging modeling approaches such as artificial intelligence are still warranted to establish their clinical utility.
1464P Asian-ethnicity related differences among patients with metastatic gastroesophageal junction (GEJ) and gastric adenocarcinoma
Authors: M.X. Honório, C. Suzuki, O. Espin-Garcia, M.J. Allen, L. Ma, F.A. Almugbel, I. Lyra Gonzalez, G. Darling, J.C-W. Yeung, E. Chen, S. Kalimuthu, R. Wong, P. Veit-Haibach, R. Jang, E. Elimova
Journal: Annals of Oncology (2020)
748P Prognostic factors related to post-platinum atezolizumab for relapsed metastatic urothelial cancer (mUC) from the SAUL study
Authors: A. Bamias, A. Merseburger, Y. Loriot, N. James, E. Choy, D. Castellano Gauna, F. Lopez-Rios, F. Calabro, M.W. Kramer, G. de Velasco, R. Zakopoulou, K. Tzannis, C.N. Sternberg
Journal: Annals of Oncology (2020)
1008P IMbrave150: Management of adverse events of special interest (AESIs) for atezolizumab (atezo) and bevacizumab (bev) in unresectable HCC
Authors: M. Ikeda, A.X. Zhu, S. Qin, T-Y. Kim, H.Y. Lim, M. Kudo, V. Breder, P. Merle, A. Kaseb, D. Li, N. Ma, M. Villalobos, S. Stanzel, V.E. Gaillard, D-Z. Xu, S. Hernandez, A-L. Cheng, R.S. Finn, P.R. Galle, M.P. Ducreux
Journal: Annals of Oncology (2020)
101P Accuracy of detecting PIK3CA mutations on circulating tumour (ct) DNA as compared to tumour tissue (TT) in breast cancer (BC) patients (pts): Results from a systematic review and meta-analysis
Authors: C. De Angelis, M. Bruzzone, R. Caparica, S. Crucitta, M. Ceppi, A. Fontana, A. Falcone, A. Prat, E. de Azambuja, M. Lambertini
Journal: Annals of Oncology (2020)
Rationally designed dual-plasmonic gold nanorod@cuprous selenide hybrid heterostructures by regioselective overgrowth for <i>in vivo</i> photothermal tumor ablation in the second near-infrared biowindow
Authors: Beibei Shan, Haitao Wang, Linhu Li, Guangzhi Zhou, Yu Wen, Mingyang Chen, Ming Li
Journal: Theranostics (2020)

NIR-II plasmonic materials offer multiple functionalities for in vivo biomedical applications, such as photothermal tumor ablation, surface-enhanced Raman scattering biosensing, photoacoustic imaging, and drug carriers. However, integration of noble metals and plasmonic semiconductors is greatly challenging because of the large lattice-mismatch. This study reports the regioselective overgrowth of Cu2-xSe on gold nanorods (GNRs) for preparation of dual-plasmonic GNR@Cu2-xSe hybrid heterostructures with tunable NIR-II plasmon resonance absorption for in vivo photothermal tumor ablation. Methods: The regioselective deposition of amorphous Se and its subsequent conversion into Cu2-xSe on the GNRs are performed by altering capping agents to produce the GNR@Cu2-xSe heterostructures of various morphologies. Their photothermal performances for NIR-II photothermal tumor ablation are evaluated both in vitro and in vivo. Results: We find that the lateral one- and two-side deposition, conformal core-shell coating and island growth of Cu2-xSe on the GNRs can be achieved using different capping agents. The Cu2-xSe domain size in these hybrids can be effectively adjusted by the SeO2 concentration, thereby tuning the NIR-II plasmon bands. A photothermal conversion efficiency up to 58-85% and superior photostability of these dual-plasmonic hybrids can be achieved under the NIR-II laser. Results also show that the photothermal conversion efficiency is dependent on the proportion of optical absorption converted into heat; however, the temperature rise is tightly related to the concentration of their constituents. The excellent NIR-II photothermal effect is further verified in the following in vitro and in vivo experiments. Conclusions: This study achieves one-side or two-side deposition, conformal core-shell coating, and island deposition of Cu2-xSe on GNRs for GNR@Cu2-xSe heterostructures with NIR-II plasmonic absorption, and further demonstrates their excellent NIR-II photothermal tumor ablation in vivo. This study provides a promising strategy for the rational design of NIR-II dual-plasmonic heterostructures and highlights their therapeutic in vivo potential.
Endoscopic necrosectomy using electric conductivity: anchoring the snare tip into a groove made with Endocut may improve necrosis grasping
Authors: Alexiane Delmeule, Jérémie Jacques, Thomas Lambin, Frédéric Moll, Alexandru Lupu, Sanaa Brahmia, Mathieu Pioche
Journal: Endoscopy (2020)

Around 20 – 30 % of all acute cases of pancreatitis are necrotizing, further marred by a 10 – 20 % mortality rate [1]. Walled-off pancreatic fluid or necrotic collections can lead to complications such as compression or secondary infection. In these cases, a step-up approach is recommended [2] [3] instead of open surgery, first with decompression by cystogastrostomy for fluid collection, followed by an endoscopic necrosectomy if solid components remain in the drained collection.
Correspondence on ‘Rheumatoid arthritis-associated DNA methylation sites in peripheral blood mononuclear cells’
Authors: Honglin Wang, Lei Niu
Journal: Annals of the Rheumatic Diseases (2020)

Correspondence on 'Rheumatoid arthritisassociated DNA methylation sites in peripheral blood mononuclear cells'We read with interest the paper by Zhu et al 1 on DNA methylation, mRNA expression and their role in the pathology of rheumatoid arthritis (RA).We found that their findings highlighted the importance of PARP9 gene DNA methylation in RA.However, we found that the study had some limitations that necessitate a cautious interpretation of the findings and merit further attention.First, 43 subjects (RA:healthy controls=25:18) were included during the discovery stage, 52 (RA:healthy controls=25:27) for DNA methylation and 70 (RA:healthy controls=35:35) for mRNA expression.However, we found that the ratio of patients to healthy controls in the first two phases was not suitable.The number of healthy controls should be greater than that of patients (patients vs healthy controls=1:R, where R is equal to or less than 4) in case-control studies.Second, patients with RA were separated into three sample sets, and the consistency of the results needs to be interpreted with caution.The main reasons for this are as follows: (1) patients with RA may have different disease status (eg, disease activity and age) across the three stages; (2) the three assays had different levels of sensitivity (ie, microarray analysis, bisulfate sequencing and real-time quantitative-PCR).However, the authors did not take these matters into account or adjust for them accordingly.Third, we do not know why the authors chose the PARP9 gene instead of other genes (eg, IFI44L and MX1) for their in vitro study.Is the PARP9 gene the most representative gene available with respect to diagnostic value?Fourth, Jurkat cells, as the authors said, are an immortal line of human T lymphocytes.They are frequently used as a cell model in studies of immune-related diseases. 2The authors used Jurkat cells to investigate the functional effects of the PARP9 gene.Are the Jurkat cells specific or RA-related?If they are not specific, we can say that these effects are also suitable for other autoimmune diseases including systemic lupus erythematosus.Lastly, the authors used T cells from patients with active RA to explore the correlation between methylation and mRNA, which may mean that their results are applicable to many situations.Because the disease activities and inflammation levels of active RA are more intense than those of stable patients, it may be more appropriate to use T cells from newly detected and newly diagnosed cases.
Quantifying the transmission of antimicrobial resistance at the human and livestock interface with genomics
Authors: Bryan A. Wee, Dishon M. Muloi, Bram A.D. van Bunnik
Journal: Clinical Microbiology and Infection (2020)

Livestock have been implicated as a reservoir for antimicrobial resistance (AMR) that can spread to humans. Close proximity and ecological interfaces involving livestock have been posited as risk factors for the transmission of AMR. In spite of this, there are sparse data and limited agreement on the transmission dynamics that occur.To identify how genome sequencing approaches can be used to quantify the dynamics of AMR transmission at the human-livestock interface, and where current knowledge can be improved to better understand the impact of transmission on the spread of AMR.Key articles investigating various aspects of AMR transmission at the human-livestock interface are discussed, with a focus on Escherichia coli.We recapitulate the current understanding of the transmission of AMR between humans and livestock based on current genomic and epidemiological approaches. We discuss how the use of well-designed, high-resolution genome sequencing studies can improve our understanding of the human-livestock interface.A better understanding of the human-livestock interface will aid in the development of evidence-based and effective One Health interventions that can ultimately reduce the burden of AMR in humans.
678P Metastasis-directed stereotactic body radiotherapy (SBRT)-guided by PET-CT 18F-choline versus PET-CT 68Ga-PSMA in castration sensitive oligorecurrent prostate cancer: A comparative effectiveness analysis
Authors: L. Nicosia, R. Mazzola, G. Francolini, L. Triggiani, G. Napoli, F. Cuccia, V. Figlia, N. Giaj-Levra, F. Ricchetti, M. Rigo, C. Vitale, L. Livi, S.M. Magrini, M. Salgarello, F. Alongi
Journal: Annals of Oncology (2020)
Marked decrease in acquired resistance to antiretrovirals in latest years in Italy
Authors: Alessia Lai, Marco Franzetti, Annalisa Bergna, Francesco Saladini, Bianca Bruzzone, Simona Di Giambenedetto, Antonio Di Biagio, Sergio Lo Caputo, Maria Mercedes Santoro, Franco Maggiolo, Saverio G. Parisi, Stefano Rusconi, Nicola Gianotti, Claudia Balotta
Journal: Clinical Microbiology and Infection (2020)
1915P The lenvatinib/pembrolizumab combination induces long lasting and complete responses in patients with metastatic anaplastic or poorly differentiated thyroid carcinoma: Results from a retrospective study and first results from the prospective phase II ATLEP trial
Authors: C. Dierks, J. Seufert, J. Ruf, J. Duyster, O. Thomusch, C. Miething, A. Zielke
Journal: Annals of Oncology (2020)
1687P Oncologists knowledge, attitude and practice in COVID-19 pandemic and its negative impact on them: An international study
Authors: A.R. Jazieh, A.K. Coutinho, A. Bensalem, A.A. Alsharm, H. Errihani, L.Y.I. Mula-Hussain, S. Al-Sukhun, C.A. Sampaio-Filho, O.M. Khorshid, R.B. De Guzman, M.O.F. Alkaiyat, H. Jradi
Journal: Annals of Oncology (2020)
Tofacitinib as monotherapy following methotrexate withdrawal in patients with psoriatic arthritis previously treated with open-label tofacitinib plus methotrexate: a randomised, placebo-controlled substudy of OPAL Balance
Authors: Peter Nash, Philip J Mease, Dona Fleishaker, Joseph Wu, Laura C Coates, Frank Behrens, Dafna D Gladman, Alan J Kivitz, James C Wei, Ivan Shirinsky, Sujatha Menon, Ana B Romero, Lara Fallon, Ming-Ann Hsu, Cunshan Wang, Keith S Kanik
Journal: The Lancet Rheumatology (2020)