tbuckley/cabot-search huggingface dataset:
Disease Trajectories for Hidradenitis Suppurativa in the Danish Population
Authors: Rune Kjærsgaard Andersen, Isabella Friis Jørgensen, Roc Reguant, Gregor Borut Ernst Jemec, Søren Brunak
Journal: JAMA Dermatology (2020)

<h3>Importance</h3> Hidradenitis suppurativa (HS) is a chronic skin disease characterized by recurrent inflamed nodular lesions and is associated with multiple comorbidities; previous studies have been of cross-sectional design, and the temporal association of HS with multiple comorbidities remains undetermined. <h3>Objective</h3> To evaluate and characterize disease trajectories in patients with HS using population-wide disease registry data. <h3>Design, Setting, and Participants</h3> This retrospective registry-based cohort study included the entire Danish population alive between January 1, 1994, and April 10, 2018 (7 191 519 unique individuals). Among these, 14 488 Danish inhabitants were diagnosed with HS or fulfilled diagnostic criteria identified through surgical procedure codes. <h3>Exposures</h3> Citizens of Denmark with a diagnosis code of HS as defined by<i>International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10)</i>or as identified through surgical procedures. <h3>Main Outcomes and Measures</h3> Disease trajectories experienced more frequently by patients with HS than by the overall Danish population. Strength of associations between disease co-occurrences was evaluated using relative risk (RR). All significant disease pairs were tested for directionality using a binomial test, and pairs with directionality were merged into disease trajectories of 3 consecutive diseases. Numerous disease trajectories were combined into a disease progression network showing the most frequent disease paths over time for patients with HS. <h3>Results</h3> A total of 11 929 individuals were identified by<i>ICD-10</i>diagnosis codes (8392 [70.3%] female; mean [SD] age, 37.72 [13.01] years), and 2791 were identified by procedural codes (1686 [60.4%] female; mean [SD] age, 37.38 [15.83]). The set of most common temporal disease trajectories included 25 diagnoses and had a characteristic appearance in which genitourinary, respiratory, or mental and behavioral disorders preceded the diagnosis of HS and chronic obstructive pulmonary disease (604 cases [4.2%]; RR, 1.57; 95% CI, 1.55-1.59;<i>P</i> &lt; .001), pneumonia (827 [5.7%]; RR, 1.18; 95% CI, 1.15-1.20;<i>P</i> &lt; .001), and acute myocardial infarction (293 [2.0%]; RR, 1.37; 95% CI, 1.35-1.39;<i>P</i> &lt; .001) developed after the diagnosis. <h3>Conclusions and Relevance</h3> The findings suggest that patients with newly diagnosed HS may have a high frequency of manifest type 1 diabetes and subsequent high risk of acute myocardial infarction, pneumonia, and chronic obstructive pulmonary disease.
Current Panorama and Challenges for Neoadjuvant Cancer Immunotherapy
Authors: Jose Carlos Benitez, Jordi Remon, Benjamin Besse
Journal: Clinical Cancer Research (2020)

Immune checkpoint inhibitors (ICI) may overcome cancer cells' ability to evade the immune system and proliferate. The long-term benefit of ICI in the metastatic setting led to evaluate neoadjuvant ICI approaches in several tumor types such as melanoma, non-small cell lung cancer, and breast and bladder cancer. We summarize the current evidence for the efficacy of neoadjuvant ICI in cancer and discuss several unresolved challenges, including the role of adjuvant treatment after neoadjuvant ICI, the efficacy in oncogenic addicted tumors, and standardizing pathologic assessment.
Abstract 13837: The Cost Of Clot: Resource Utilization and Outcomes in Children With Thrombosis After Cardiac Surgery
Authors: Jason T Patregnani, Lina Lander, Pranava Sinha, Rahul Shah
Journal: Circulation (2019)

Introduction: The incidence of pediatric hospital associated thrombosis continues to rise. Children undergoing repair of congenital heart disease are known to be at higher risk and the presence of ...
Metabolic Remodeling of Neutrophils at Inflammatory Site Drives Invadosome Formation Favoring Transcellular Migration
Authors: Chanchal Sur Chowdhury, Elizabeth Wareham, Juying Xu, Sachin Kumar, Ashwini S. Hinge, Sribalaji Lakshmikanthan, Magdalena Chrzanowska-Wodnicka, Marie-Dominique Filippi, PhD
Journal: Blood (2017)
Gender Bias and Stereotypes in Surgical Training
Authors: Caprice C. Greenberg, Jacob A. Greenberg
Journal: JAMA Surgery (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Midline Granuloma
Authors: RICHARD A. DEREMEE
Journal: Annals of Internal Medicine (1976)

Comments and Corrections1 July 1976Midline GranulomaRICHARD A. DEREMEE, M.D., F.A.C.P., THOMAS J. MCDONALD, M.D.RICHARD A. DEREMEE, M.D., F.A.C.P.Search for more papers by this author, THOMAS J. MCDONALD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-1-128_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We were interested to read the paper, "Radiation Therapy of Midline Granuloma" by Fauci, Johnson, and Wolff (Ann Intern Med84:140-147, 1976). They report, however, a concept and experience at variance with ours. Granulomatous lesions of the nose, as we have seen them, have usually been conveniently classifiable as either necrotizing granuloma with vasculitis consistent with Wegener's granulomatosis, polymorphic reticulosis ( 1 ), specific infectious granuloma, or lymphoma. The non-specific pathologic features referred to in the paper have suggested to us either that the biopsy was inadequate or that the disease process has not yet evolved into...Reference1. MCDONALD T, DEREMEE R, and HARRISON E: The protean clinical features of polymorphic reticulosis (lethal midline granuloma). Laryngoscope, in press Google Scholar1. WALTON E: Non-healing granulomata of the nose. J Laryngol Otol 73:242-260, 1959 CrossrefMedlineGoogle Scholar2. FRIEDMANN I: Midline granuloma. Proc R Soc Med 57:289-297, 1964 MedlineGoogle Scholar3. GODMAN G and CHURG J: Wegener's granulomatosis. Pathology and review of the literature. Arch Pathol 58:533-553, 1954 MedlineGoogle Scholar4. FAUCI A and WOLFF S: Wegener's granulomatosis: studies in eighteen patients and a review of the literature. Medicine 52:535-561, 1973 CrossrefMedlineGoogle Scholar1. ABRAMS A, MELROSE R, and HOWELL F: Necrotizing sialometaplasia. A disease simulating malignancy. Cancer 32:130-135, 1973 CrossrefMedlineGoogle Scholar2. FECHNER R and WILLS P: Necrotizing sialometaplasia. Arch Otolaryngol 101:76-78, 1975 CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RICHARD A. DEREMEE, M.D., F.A.C.P.; THOMAS J. MCDONALD, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1976Volume 85, Issue 1Page: 128-129KeywordsBiopsyGranulomasLesionsLymphomaRadiation therapyVasculitisWegener granulomatosis ePublished: 1 December 2008 Issue Published: 1 July 1976 PDF downloadLoading ...
The Sound of Grief
Authors: Elizabeth L. Mitchell
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Real‐world effectiveness of eliglustat in treatment‐naïve and switch patients enrolled in the International Collaborative Gaucher Group Gaucher Registry
Authors: Pramod K. Mistry, Manisha Balwani, Joel Charrow, Priya Kishnani, Claus Niederau, Lisa H. Underhill, Monica R. McClain
Journal: American Journal of Hematology (2020)

Eliglustat is a first-line oral therapy for adults with Gaucher disease type 1 (GD1) with extensive, intermediate, or poor CYP2D6-metabolizer phenotypes (90% of patients). We report real-world outcomes after 2 years of eliglustat therapy in the International Collaborative Gaucher Group Gaucher Registry (NCT00358943). As of January 2019, baseline and 2-year data (±1 year) were available for 231 eliglustat-treated GD1 patients: 19 treatment-naïve (zero splenectomized) and 212 ERT patients who switched to eliglustat (36 splenectomized). Most patients (89%) were from the United States, where eliglustat was first approved. In treatment-naïve patients, mean hemoglobin increased from 12.4 to 13.4 g/dL (P = .004, n = 18), mean platelet count increased from 113 to 156 × 109 /L (P < .001, n = 17); mean spleen volume decreased from 7.4 to 3.5 multiples of normal (MN) (P = .02, n = 7); mean liver volume remained normal (n = 7), and median spine Z-score was unchanged (-1.3 to -1.2, n = 6). In non-splenectomized switch patients, mean hemoglobin remained stable/non-anemic (n = 167); mean platelet count remained stable/normal (n = 165); mean spleen volume decreased from 3.3 to 2.8 MN (P < .001, n = 64); mean liver volume remained normal (n = 63), and median lumbar spine Z-score improved from -0.7 to -0.4 (P = .014, n = 68). In splenectomized switch patients, mean hemoglobin remained stable/non-anemic (n = 31); mean platelet count increased from 297 to 324 × 109 /L (non-significant, n = 29); mean liver volume remained normal (n = 13); median spine Z-score improved from -0.8 to -0.6 (non-significant, n = 11). Median chitotriosidase decreased in all groups (P < .01 for all). These real-world results are consistent with eliglustat clinical trial results demonstrating long-term benefit in treatment-naïve patients and stability in ERT switch patients.
The Interleukin 22 Pathway Interacts with Mutant KRAS to Promote Poor Prognosis in Colon Cancer
Authors: Sarah McCuaig, David Barras, Elizabeth H. Mann, Matthias Friedrich, Samuel J. Bullers, Alina Janney, Lucy C. Garner, Enric Domingo, Viktor Hendrik Koelzer, Mauro Delorenzi, Sabine Tejpar, Timothy S. Maughan, Nathaniel R. West, Fiona Powrie
Journal: Clinical Cancer Research (2020)

Abstract Purpose: The cytokine IL22 promotes tumor progression in murine models of colorectal cancer. However, the clinical significance of IL22 in human colorectal cancer remains unclear. We sought to determine whether the IL22 pathway is associated with prognosis in human colorectal cancer, and to identify mechanisms by which IL22 can influence disease progression. Experimental Design: Transcriptomic data from stage II/III colon cancers in independent discovery (GSE39582 population-based cohort, N = 566) and verification (PETACC3 clinical trial, N = 752) datasets were used to investigate the association between IL22 receptor expression (encoded by the genes IL22RA1 and IL10RB), tumor mutation status, and clinical outcome using Cox proportional hazard models. Functional interactions between IL22 and mutant KRAS were elucidated using human colorectal cancer cell lines and primary tumor organoids. Results: Transcriptomic analysis revealed a poor-prognosis subset of tumors characterized by high expression of IL22RA1, the alpha subunit of the heterodimeric IL22 receptor, and KRAS mutation [relapse-free survival (RFS): HR = 2.93, P = 0.0006; overall survival (OS): HR = 2.45, P = 0.0023]. KRAS mutations showed a similar interaction with IL10RB and conferred the worst prognosis in tumors with high expression of both IL22RA1 and IL10RB (RFS: HR = 3.81, P = 0.0036; OS: HR = 3.90, P = 0.0050). Analysis of human colorectal cancer cell lines and primary tumor organoids, including an isogenic cell line pair that differed only in KRAS mutation status, showed that IL22 and mutant KRAS cooperatively enhance cancer cell proliferation, in part through augmentation of the Myc pathway. Conclusions: Interactions between KRAS and IL22 signaling may underlie a previously unrecognized subset of clinically aggressive colorectal cancer that could benefit from therapeutic modulation of the IL22 pathway.
Radioiodine Retention Within Dilated Common Biliary Duct Mimicking Metastatic Thyroid Cancer Diagnosed by the Combination of SPECT/CT and MRI
Authors: Hongyuan Dai, Rui Huang
Journal: Clinical Nuclear Medicine (2020)

Abstract A 55-year-old woman with papillary thyroid carcinoma under total thyroidectomy and cervical lymph node dissection was referred for 131 I radioiodine therapy. Posttherapeutic whole-body scintigraphy revealed increased focal uptake in the right upper abdomen, which localized to the region of the head of the pancreas on SPECT/CT fusion images. Further evaluation with MRI affirmed the radioiodine retention corresponded to bile duct dilation.
Comment on Koromani et al. Vertebral Fractures in Individuals With Type 2 Diabetes: More Than Skeletal Complications Alone. Diabetes Care 2020;43:137–144
Authors: Raffaella Mormile
Journal: Diabetes Care (2020)

In a recent publication, Koromani et al. (1) focused on vertebral fractures (VFs) in patients affected by type 2 diabetes (T2D) (1). They conducted a systematic PubMed search to identify studies that examined the association between T2D and VFs (1). The authors also assessed cohorts providing individual participant data (IPD) (1). They evaluated 15 studies including 852,705 men and women (1). They conclude that individuals suffering from T2D should be systematically examined for presence of VFs, and, as in individuals without T2D, the finding of VFs represents an …
The right treatment for the right patient with COPD: lessons from the IMPACT trial
Authors: Daiana Stolz, Marc Miravitlles
Journal: European Respiratory Journal (2020)

Long-acting bronchodilators are the basis of treatment for COPD [1]; however, there are some patients who suffer from frequent or severe exacerbations, despite maximal bronchodilation [2]. These patients are at increased risk of death and represent a great challenge in clinical practice [3]. Inhaled corticosteroids (ICS) are the basis of the treatment of asthma and are also effective, albeit to a lesser extent, in some patients with COPD [4]. Generally speaking, ICS are indicated in patients with COPD and exacerbations, despite bronchodilator treatment [1]. Different patient characteristics have to be considered for prescription of triple therapy in COPD <https://bit.ly/2xWq7lW>
66P Impact of EPClin on adjuvant therapeutic decision-making and comparison of EPClin to PREDICT tool
Authors: H. Bourien, V. Quillien, F. Godey, C. Perrin, F. Le Du, A. Brunot, L. Crouzet, T. de La Motte Rouge, V. Dieras, C. Lefeuvre-Plesse
Journal: Annals of Oncology (2020)
Oral iron supplementation with ferric maltol in patients with pulmonary hypertension
Authors: Karen M. Olsson, Jan Fuge, Torben Brod, Jan C. Kamp, Jan Schmitto, Tibor Kempf, Johann Bauersachs, Marius M. Hoeper
Journal: European Respiratory Journal (2020)

<b>Oral ferric maltol was well tolerated and effective in patients with pulmonary hypertension and iron deficiency anaemia. Restoration of iron stores corrected anaemia and resulted in improved right ventricular function and exercise tolerance</b>https://bit.ly/2zMwvxc
Abstract 85: Early Detection of Kawasaki Disease in Infants
Authors: Ji Hae Kang, Dong-Seok Lee, In Ae Seo, Min Ha Kwak, Sung Min Choi, Doo Kwon Kim, Seung Man Cho
Journal: Circulation (2015)

Background and Objective: This study was aimed to investigate clinical characteristics of infantile Kawasaki disease (KD), and to evaluate early diagnostic features of KD in febrile infants. Subjects and Methods: We retrospectively reviewed the medical records of 66 patients with KD who were admitted to Dongguk University Gyeongju Hospital, between January 2010 and August 2014. The clinical, laboratory data between infants and children were analyzed. And the clinical and laboratory data of infantile KD patients were compared with 18 infants who were admitted for other acute febrile disease during same period as above. Results: A total of 66 patients were identified; 21(31.8%) were infants; 45(68.2%) were &gt; 1 year old children. Incomplete KD was much more common in infants (n=15, 71.4%) than in children group (n=14, 31.1%) (P = 0.002). The infants group was characterized by significantly higher rates of inflammatory changes at the Bacille Calmett-Guerin (BCG) inoculation site (P&lt;0.001), but lower rates of changes in the cervical lymphadenopathy (P=0.005), conjunctival injection (P=0.047). The serum levels of hemoglobin were lower (P&lt;0.001), and platelet (P=0.029), C-reactive protein (P=0.042), N-terminal pro-brain natriuretic peptide (NT-proBNP) (P=0.042) was higher in the infants group significantly. Pyuria was also significantly higher in the infants group (P=0.017). Between infants with KD and with other acute febrile diseases, there were significantly higher serum levels of ESR (P&lt;0.001), CRP (P=0.009) and NT-proBNP (P=0.002) in the infantile KD. Conclusion: Because incomplete KD was much more in infants, the diagnosis of infantile KD can be difficult. The BCGitis and higher level of NT-proBNP can help to early diagnosis of incomplete KD in infants, and may be a good predictor of KD in acute febrile infants combined with other acute phase reactants.
From the Office of the General Counsel. Collective negotiation and physician unions
Authors: M. L. Ile
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
68Ga-DOTATATE Uptake in an Endolymphatic Sac Tumor
Authors: Robert Lou, Jillian W. Lazor, Ezra Baraban, Jeffrey B. Ware, Kumarasen Cooper, Austin R. Pantel
Journal: Clinical Nuclear Medicine (2020)

Abstract After dedicated CT and MRI, 68 Ga-DOTATATE PET/CT was performed in a patient with a temporal bone mass with primary diagnostic considerations of an endolymphatic sac tumor versus a glomus jugulotympanicum paraganglioma. The 68 Ga-DOTATATE PET showed mild radiotracer uptake in the mass (SUV max , 10.9). After surgical resection, pathology revealed an endolymphatic sac tumor. Immunohistochemical staining demonstrated somatostatin receptor type 2A expression in the vasculature of the mass, but not in the tumor cells.
Time for Action to Address the Persistent Sex-Based Disparity in Liver Transplant Access
Authors: Elizabeth C. Verna, Jennifer C. Lai
Journal: JAMA Surgery (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal