tbuckley/cabot-search huggingface dataset:
Primary tumor resection after nivolumab treatment for metastatic renal cell carcinoma: A case report
Authors: Tokiyoshi Tanegashima, Shigehiro Tsukahara, Takashi Ikenoue, Satoshi Otsubo, Shuji Hasehawa, Hiroyoshi Nishikawa, Masatoshi Eto
Journal: Annals of Oncology (2019)
Determining the Optimal Timing of Initiation for Venous Thromboembolism (VTE) Anticoagulant (AC) Prophylaxis (proph) after Orthopedic Surgery (OS).
Authors: Alejandro Lazo-Langner, Douglas A. Coyle, Philip S. Wells, Dimitrios Scarvelis, Melissa A. Forgie, Marc A. Rodger
Journal: Blood (2007)
Derivation of Disease-Free Induced Pluripotent Stem Cells From Patients with Pearson Marrow Pancreas Syndrome
Authors: Suneet Agarwal, Anne B.C. Cherry, Erin M. McLoughlin, Paul H. Lerou, Justine D. Miller, Hongguang Huo, Odelya Hartung, Rebecca L. Zon, Mark D. Fleming, Tan A. Ince, Ellis J. Neufeld, George Q. Daley
Journal: Blood (2010)
Clinical Presentation and Outcome of Patients with Myeloid Differentiation Factor 88 Gene (MYD88) Wild-Type Waldenstrom Macroglobulinemia
Authors: Jithma P Abeykoon, Jonas Paludo, Prashant Kapoor, Wilson I Gonsalves, Morie A. Gertz, Stephen Ansell, Rong He, Ronald S. Go, Francis K. Baudi, S. Vincent Rajkumar, Shaji Kumar, Rebecca L King
Journal: Blood (2016)
Chronic intermittent tachypacing by an optogenetic approach induces arrhythmia vulnerability in human engineered heart tissue
Authors: Marta Lemme, Ingke Braren, Maksymilian Prondzynski, Bülent Aksehirlioglu, Bärbel M Ulmer, Mirja L Schulze, Djemail Ismaili, Christian Meyer, Arne Hansen, Torsten Christ, Marc D Lemoine, Thomas Eschenhagen
Journal: Cardiovascular Research (2019)

Chronic tachypacing is commonly used in animals to induce cardiac dysfunction and to study mechanisms of heart failure and arrhythmogenesis. Human induced pluripotent stem cells (hiPSC) may replace animal models to overcome species differences and ethical problems. Here, 3D engineered heart tissue (EHT) was used to investigate the effect of chronic tachypacing on hiPSC-cardiomyocytes (hiPSC-CMs).To avoid cell toxicity by electrical pacing, we developed an optogenetic approach. EHTs were transduced with lentivirus expressing channelrhodopsin-2 (H134R) and stimulated by 15 s bursts of blue light pulses (0.3 mW/mm2, 30 ms, 3 Hz) separated by 15 s without pacing for 3 weeks. Chronic optical tachypacing did not affect contractile peak force, but induced faster contraction kinetics, shorter action potentials, and shorter effective refractory periods. This electrical remodelling increased vulnerability to tachycardia episodes upon electrical burst pacing. Lower calsequestrin 2 protein levels, faster diastolic depolarization (DD) and efficacy of JTV-519 (46% at 1 µmol/L) to terminate tachycardia indicate alterations of Ca2+ handling being part of the underlying mechanism. However, other antiarrhythmic compounds like flecainide (69% at 1 µmol/L) and E-4031 (100% at 1 µmol/L) were also effective, but not ivabradine (1 µmol/L) or SEA0400 (10 µmol/L).We demonstrated a high vulnerability to tachycardia of optically tachypaced hiPSC-CMs in EHT and the effective termination by ryanodine receptor stabilization, sodium or hERG potassium channel inhibition. This new model might serve as a preclinical tool to test antiarrhythmic drugs increasing the insight in treating ventricular tachycardia.
Genome Editing of the Bcl11A Erythroid Specific Enhancer in Bone Marrow Derived Hematopoietic Stem and Progenitor Cells for the Treatment of Sickle Cell Disease
Authors: Siyuan Tan, Kai-Hsin Chang, Sarah Smith, Kai Chen, Timonthy Sullivan, Qianhe Zhou, Andreas Reik, Fyodor D Urnov, Edward J. Rebar, Olivier Danos, Haiyan Jiang
Journal: Blood (2015)
Comparison Of Umbilical Cord Blood and Haploidentical Donor Grafts In Adults With High Risk Hematologic Diseases After Fludarabine Cyclophosphamide and TBI 2 Gy Based Reduced-Intensity Conditioning Regimen Stem Cell Transplantation
Authors: El-Cheikh Jean, Crocchiolo Roberto, Fürst Sabine, Bramanti Stefania, Sarina Barbara, Granata Angela, Faucher Catherine, Mohty Bilal, Harbi Samia, Bouabdallah Reda, Vey Norbert, Santoro Armando, Chabannon Christian, Castagna Luca, Didier Blaise
Journal: Blood (2013)
In AML Secondary to MDS NPM1 Mutations Are Late Events, Less Frequent, and Associated with a Different Pattern of Molecular Mutations Than in De Novo AML
Authors: Susanne Schnittger, Claudia Haferlach, Niroshan Nadarajah, Tamara Alpermann, Manja Meggendorfer, Karolina Perglerová, Wolfgang Kern, Torsten Haferlach
Journal: Blood (2014)
Stable Silencing of RUNX1/ETO Induces Expression of a Shortened PU.1 Variant in t(8;21) Kasumi Cells
Authors: Matthias Eder, Caroline Schoenherr, Katharina Wohlan, Fabian Frömling, Denise Hilfiker-Kleiner, Arnold Ganser, Michaela Scherr
Journal: Blood (2016)
Apoptotic Death of Bcr-Abl-Expressing Myeloid Progenitors in Response to the m-Tor Inhibitor RAD001 (Everolimus) Is Promoted by the Nuclear Import of c-Abl.
Authors: Manuela Mancini, Elisa Zuffa, Patrizia Corrado, Gianluca Brusa, Sara Petta, Eleonora Pagnotta, Maria Alessandra Santucci
Journal: Blood (2006)
UTX mutations in Myeloid Neoplasms
Authors: Yasunobu Nagata, Tomas Radivoyevitch, Hideki Makishima, Cassandra M. Hirsch, Bartlomiej P Przychodzen, Teodora Kuzmanovic, Eiju Negoro, Michael J. Clemente, Sudipto Mukherjee, Hetty E. Carraway, Mikkael A. Sekeres, Jaroslaw P Maciejewski
Journal: Blood (2016)
Clinical Impact of an Internet-Based Tool to Help Guide Therapeutic Changes While Monitoring Patients with Chronic Myeloid Leukemia Receiving First-Line Tyrosine Kinase Inhibitor Therapy
Authors: Kevin L. Obholz, Daniel J. DeAngelo, Michael J. Mauro, Neil Shah, B. Douglas Smith, Andrew Bowser, Eric D. Peterson, Jerald P. Radich
Journal: Blood (2012)
Abstract 19460: Antidepressants Attenuate the Effect of Mental Stress on the Left Atrial Electrophysiology
Authors: Zakaria Almuwaqqat, Wesley O'neal, Muhammad Hammadah, Naser Abdelhadi, Mohamad Mazen Gafeer, Kobina Wilmot, Ronnie Ramadan, ibhar Al Mheid, Doug Bremner, Michael Kutner, Arshed Quyyumi, Elsayed Z Soliman, Viola Vaccarino, Paolo Raggi, Amit J Shah
Journal: Circulation (2017)

Background: The risk of new-onset atrial fibrillation (AF) is associated with acute episodes of sadness, anxiety, anger, and stress. Antidepressants (ADs) may help stabilize emotional lability and,...
Mortality and Resource Utilization in Children with De Novo Acute Myeloid Leukemia Treated with Chemotherapy and Gemtuzumab Ozogamicin in the United States
Authors: Marko Kavcic, Brian T. Fisher, Yimei Li, Alix E. Seif, Kari Torp, Yuan-Shung Huang, Grace E. Lee, Sarah K Tasian, Ami V. Desai, Marijana Vujkovic, Rochelle Bagatell, Richard Aplenc
Journal: Blood (2012)
Inhibition of CDK4/CDK6 Sensitizes Myeloma to IMiD By Reducing the MEIS2 to Cereblon Ratio That Accelerates IKZF1 and IKZF3 Degradation
Authors: Xiangao Huang, David Jayabalan, Maurizio Di Liberto, Zhengming Chen, Anna C Schinzel, Scott Ely, Adriana C Rossi, Roger N Pearse, Ekta Aneja, Morton Coleman, Joseph M Lane, William C. Hahn, Tomer M Mark, Ruben Niesvizky, Selina Chen-Kiang
Journal: Blood (2015)
CLL Subsets with Distinct Stereotyped B Cell Receptors Have Distinct Epigenetic Make-up, Even Beyond IGHV Gene Mutational Status: DNA Methylation Profiling of IGHV-Unmutated CLL Stereotyped Subsets #6 and #8
Authors: Nikos Papakonstantinou, Jana Gutwein, Ole Ammerpohl, Eva Koravou, Chrysoula Belessi, Reiner Siebert, Michael Kneba, Matthias Ritgen, Kostas Stamatopoulos, Christiane Pott
Journal: Blood (2012)
Phase 1b Study Of Otlertuzumab (TRU-016), An Anti-CD37 ADAPTIR™ Protein, In Combination With Rituximab In Patients With Previously Untreated Chronic Lymphocytic Leukemia (CLL)
Authors: Kami Maddocks, John M. Pagel, Susan O'Brien, John C. Byrd, Scott Stromatt, Farrukh T Awan
Journal: Blood (2013)
Selection of a Suitable Rapid Turn Around and Sensitive Test for the Laboratory Monitoring of Newer Oral Anticoagulants, Rivaroxaban, Apixaban and Dabigatran,
Authors: Debra Hoppensteadt, Jeanine M. Walenga, Josephine Cunanan, Omer Iqbal, Bruce E Lewis, Evi Kalodiki, Stephen Kahn, Jawed Fareed
Journal: Blood (2011)
Clonal Involvement of the CD34+CD33− Progenitor Population by Leukemic Cells Harboring FLT3/ITD Correlates with High Risk of Relapse in Pediatric Acute Myeloid Leukemia.
Authors: Jessica A. Wright, Todd A. Alonzo, Robert B. Gerbing, William G. Woods, Beverly J. Lange, Jerald P. Radich, Irwin D. Bernstein, Soheil Meshinchi
Journal: Blood (2005)
KIR Genes and Their HLA-C Ligands in B-Cell Chronic Lymphocytic Leukemia in a Polish Population.
Authors: Irena Frydecka, Anna Jedynak, Lidia Karabon, Edyta Pawlak, Anna Tomkiewicz, Marek Kielbinski, Dariusz Woszczyk, Dariusz Wolowiec, Kazimierz Kuliczkowski
Journal: Blood (2009)
Refractory Cytopenia In Childhood (RCC) with Normal Karyotype Is Unlikely to Progress to Advanced MDS Under a Watch and Wait Strategy
Authors: Shinsuke Hirabayashi, Brigitte Strahm, Stephan Schwarz, Marco Zecca, Markus Schmugge, Michael Dworzak, Marry van den Heuvel-Eibrink, Henrik Hasle, Barbara De Moerloose, Jan Stary, Dorota Wojcik, Ingrid Furlan, Franco Locatelli, Irith Baumann, Charlotte M Niemeyer
Journal: Blood (2010)
High Rates of Molecular Response and Low Incidence of Mutations in Patients Treated with Newly Diagnosed Chronic Myeloid Leukemia (CML) Treated with a Dose-Escalated Combination of Imatinib and Cytarabin.
Authors: Jan J. Cornelissen, Peter Valk, Gregor E.G. Verhoef, Wim M. Smit, Marinus van Marwijk-Kooij, Shulamit Wittebol, Marinus H.J. van Oers, Hanneke C. Kluin-Nelemans, Bob Lowenberg, Roelof Willemze, Antonius V.M.B. Schattenberg, Gert Ossenkoppele
Journal: Blood (2004)
Bendamustine + Rituximab (BR) Chemoimmunotherapy and Maintenance Lenalidomide in Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia (CLL) and Small Lymphocytic Lymphoma (SLL): A Wisconsin Oncology Network (WON) Study
Authors: Julie E. Chang, Chong Zhang, KyungMann Kim, Rachel Kirby, Lynn Volk, Jae Werndli, Ronald S. Go, Matthias Weiss, Jules H. Blank, Michael A. Thompson, John P. Farnen, Craig E. Cole, Ali W. Bseiso, Michael Volk, Gerald Bayer, Tim Wassenaar, Patrick Mansky, Anne Traynor, Timothy S. Fenske, Brad S. Kahl
Journal: Blood (2012)
The Accuracy of the Patient Health Questionnaire-9 Algorithm for Screening to Detect Major Depression: An Individual Participant Data Meta-Analysis
Authors: Chen He, Brooke Levis, Kira E. Riehm, Nazanin Saadat, Alexander W. Levis, Marleine Azar, Danielle B. Rice, Ankur Krishnan, Yin Wu, Ying Sun, Mahrukh Imran, Jill Boruff, Pim Cuijpers, Simon Gilbody, John P.A. Ioannidis, Lorie A. Kloda, Dean McMillan, Scott B. Patten, Ian Shrier, Roy C. Ziegelstein, Dickens H. Akena, Bruce Arroll, Liat Ayalon, Hamid R. Baradaran, Murray Baron, Anna Beraldi, Charles H. Bombardier, Peter Butterworth, Gregory Carter, Marcos Hortes Nisihara Chagas, Juliana C.N. Chan, Rushina Cholera, Kerrie Clover, Yeates Conwell, Janneke M. de Man-van Ginkel, Jesse R. Fann, Felix H. Fischer, Daniel Fung, Bizu  Gelaye, Felicity Goodyear-Smith, Catherine G. Greeno, Brian J. Hall, Patricia A. Harrison, Martin Härter, Ulrich Hegerl, Leanne Hides, Stevan E. Hobfoll, Marie Hudson, Thomas N. Hyphantis, Masatoshi Inagaki, Khalida Ismail, Nathalie Jetté, Mohammad E. Khamseh, Kim M. Kiely, Yunxin Kwan, Femke Lamers, Shen-Ing Liu, Manote Lotrakul, Sonia R. Loureiro, Bernd Löwe, Laura Marsh, Anthony McGuire, Sherina Mohd-Sidik, Tiago N. Munhoz, Kumiko Muramatsu, Flávia L. Osório, Vikram Patel, Brian W. Pence, Philippe Persoons, Angelo Picardi, Katrin Reuter, Alasdair G. Rooney, Iná S. da Silva dos Santos, Juwita Shaaban, Abbey Sidebottom, Adam Simning, Lesley Stafford, Sharon Sung, Pei Lin Lynnette Tan, Alyna Turner, Henk C.P.M. van Weert, Jennifer White, Mary A. Whooley, Kirsty Winkley, Mitsuhiko Yamada, Brett D. Thombs, Andrea Benedetti
Journal: Psychotherapy and Psychosomatics (2019)

Screening for major depression with the Patient Health Questionnaire-9 (PHQ-9) can be done using a cutoff or the PHQ-9 diagnostic algorithm. Many primary studies publish results for only one approach, and previous meta-analyses of the algorithm approach included only a subset of primary studies that collected data and could have published results.
Targeting Hypoxia and AKR1C3 with PR104 in Patients with Acute Leukemia
Authors: Juliana M Benito, Hongbo Lu, William R Wilson, Teresa J Melink, Jennie Bretz, Sergej Konoplev, Elihu H. Estey, Hagop M. Kantarjian, John C Gutheil, Michael Andreeff, Marina Konopleva
Journal: Blood (2012)
Casein Kinase-2 Induces Constitutive Phosphorylation of STAT3 in CLL Cells
Authors: Uri Rozovski, David M. Harris, Ping LI, Zhiming Liu, Preetesh Jain, Alessandra Ferrajoli, Jan A. Burger, Susan M. O'Brien, Prithviraj Bose, Philip A. Thompson, Nitin Jain, William G. Wierda, Michael Keating, Zeev Estrov
Journal: Blood (2016)
Quantifying the Possible Consequences of Parathyroidectomy on Hypertension in Patients With Primary Hyperparathyroidism
Authors: Wen T. Shen
Journal: JAMA Surgery (2019)

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Prevention of Morbidity in Sickle Cell Disease (POMS 2): A Pilot Study of Nocturnal Respiratory Support Shows That Auto-Adjusting Positive Airways Pressure Is Safe and Is Preferred to Oxygen Therapy
Authors: Jo Howard, Baba Inusa, Christina Liossi, David C. Rees, Swee Lay Thein, Edith Cheng, Sati Sahota, Nicholas Hart, Patrick Murphy, Johanna Gavlak, Maria Chorozoglou, Eufemia Jacob, Carol Nwosu, Maureen Gwam, SallyAnn Wakeford, Fenella Kirkham
Journal: Blood (2015)
Abstract 673: Exploration of tissue morphologies in breast cancer samples using unsupervised machine learning
Authors: Riku Turkki, Dmitrii Bychkov, Nina Linder, Jorma Isola, Heikki Joensuu, Johan Lundin
Journal: Cancer Research (2017)

Abstract We applied a machine learning approach for exploration of tissue morphology in hematoxylin and eosin (H&amp;E) stained breast cancer tissue microarray (TMA) samples. We then investigated whether the morphological categories produced were associated with clinically relevant molecular biomarkers and 10-year overall survival. The data set comprises digitized (0.22 µm/pixel) and H&amp;E stained TMA spots from tumor samples of 490 women who were diagnosed with primary breast cancer within a Finnish breast cancer database (FinProg) collected in 1991 and 1992. In order to quantitatively describe the tissue morphologies of the TMA spots, we divided the tissue images into rectangular sub-images (224x224 pixels), and extracted features with a pre-trained convolutional neural network. We then clustered the sub-images (n=147,266) with a non-linear data embedding algorithm that creates a two-dimensional mapping of the tissue morphologies. Lastly, we defined a quantitative profile for each tumor, describing the morphologies within the tissue spot image by dividing the two-dimensional map of morphologies into 128 separate clusters with k-nearest neighbor clustering. Visual inspection of the two-dimensional embedding of tissue spot images verified that the morphologies clustered coherently, i.e. similar looking sub-images formed distinct clusters in the map. Interestingly, some morphological patterns were strongly associated with tumor estrogen receptor content, progesterone receptor content, human epidermal growth factor receptor 2 status, and the proliferation marker Ki-67 status (p&amp;lt;0.0001 for each comparison). In exploratory analyses we identified one morphological category that was associated with a favorable 10-year overall survival with a risk ratio of 0.68 (CI95% 0.53-0.89, p=0.002, power = 0.87). Our work demonstrates that unsupervised machine learning can be applied to explore and better understand the role of morphological patterns in breast cancer. Methods that quantitatively assess the morphology of cancer tissue may complement molecular biomarkers and potentially reveal novel prognostic and predictive factors. Citation Format: Riku Turkki, Dmitrii Bychkov, Nina Linder, Jorma Isola, Heikki Joensuu, Johan Lundin. Exploration of tissue morphologies in breast cancer samples using unsupervised machine learning [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 673. doi:10.1158/1538-7445.AM2017-673
Preliminary Results of a Phase 1 Trial Evaluating MRG-106, a Synthetic microRNA Antagonist (LNA antimiR) of microRNA-155, in Patients with CTCL
Authors: Christiane Querfeld, Theresa Pacheco, Francine M. Foss, Ahmad S. Halwani, Pierluigi Porcu, Anita G Seto, Judy Ruckman, Michele L Landry, Aimee L Jackson, Linda A Pestano, Brent A Dickinson, Mark Sanseverino, David M Rodman, Gilad Gordon, William Marshall
Journal: Blood (2016)
Variations in Surveillance Imaging for Patients with Treated Diffuse Large B-Cell Lymphoma in the National Comprehensive Cancer Network (NCCN) Lymphoma Database.
Authors: Gregory A. Abel, Ann Vanderplas, Jonathan W. Friedberg, Joyce Niland, Maria A. Rodriguez, Myron S Czuczman, Michael Millenson, Allison L. Crosby, Leo I. Gordon, Douglas W. Blayney, Andrew D. Zelenetz, Ann S. LaCasce
Journal: Blood (2009)
A Simple Clinical Prognostic Scoring System for Newly Diagnosed Cytogenetically Normal Acute Myeloid Leukemia: a Retrospective Analysis on 530 Patients
Authors: Michele Malagola, Crisitina Skert, Marco Vignetti, Alfonso Piciocchi, Giovanni Martinelli, Cristina Mecucci, Nicoletta Testoni, Ilaria Iacobucci, Marino Clavio, Marco Gobbi, Candoni Anna, Daniela Damiani, Monica Bocchia, Francesco Lauria, Alfonso Zaccaria, Patrizio Mazza, Giuseppe Visani, Peli Annalisa, Marco Mancini, Robin Foà, Massimo Martelli, Nicola Cantore, Francesco Di Raimondo, Mario Petrini, Paolo de Fabritiis, Giuseppe Fioritoni, Francesco Nobile, Francesco Fabbiano, Giorgina Specchia, Michele Baccarani, Francesco Lo Coco, Sergio Amadori, Franco Mandelli, Domenico Russo
Journal: Blood (2010)
Author Correction: Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways
Authors: Evan Der, Hemant Suryawanshi, Pavel Morozov, Manjunath Kustagi, Beatrice Goilav, Saritha Ranabothu, Peter Izmirly, Robert Clancy, H. Michael Belmont, Mordecai Koenigsberg, Michele Mokrzycki, Helen Rominieki, Jay A. Graham, Juan P. Rocca, Nicole Bornkamp, Nicole Jordan, Emma Schulte, Ming Wu, James Pullman, Kamil Slowikowski, Soumya Raychaudhuri, Joel Guthridge, Judith James, Jill Buyon, Thomas Tuschl, Chaim Putterman
Journal: Nature Immunology (2019)
UNC2025, a Small Molecule MerTK and Flt3 Tyrosine Kinase Inhibitor, Decreases Disease Burden, Prolongs Survival, and Promotes Sensitivity to Chemotherapy in Xenograft Models of Acute Leukemia
Authors: Deborah DeRyckere, Alisa B. Lee-Sherick, Amanda A. Hill, Lauren Page, Xiaodong Wang, Stephen V. Frye, H. Shelton Earp, Douglas K. Graham
Journal: Blood (2014)
Cytogenetic and Molecular Responses in Patients with Chronic-Phase Chronic Myeloid Leukemia (CP-CML) in a Prospective Observational Study (SIMPLICITY)
Authors: Michael Mauro, Carlo Gambacorti-Passerini, Stuart L Goldberg, Jorge E. Cortes, H. Jean Khoury, Mauricette Michallet, Ronald Paquette, Bengt Simonsson, Michelle P Turner, Hesham Mohamed, Milayna Subar, Teresa Zyczynski
Journal: Blood (2014)
Patterns of Disease Relapse and Progression in Patients with Multiple Myeloma After First Line Therapy with Autologous Stem Cell Transplantation: Implications for Patient Monitoring After Transplantation
Authors: Dmitriy Zamarin, Manisha Bhutani, Danielle Chimento, Sergio Giralt, Nikoletta Lendvai, Heather Landau, Alex Lesokhin, David Chung, Dilip Babu, Hani Hassoun
Journal: Blood (2011)
NPI-0052 and gamma-radiation induce a synergistic apoptotic effect in the most aggressive medulloblastoma subgroup
Authors: Eleni Frisira, Fatima Rashid, David Michod, Maria Victoria Niklison Chirou
Journal: Neuro-Oncology (2019)

Abstract Group 3 medulloblastoma (MB) is the most aggressive and least characterised of all MB subgroups. These tumours are highly metastatic and patients undergo aggressive treatments leaving survivors with severe side effects. The standard of care for these patients consists of surgical resection followed by gamma-radiation and chemotherapy. Whilst this conventional therapy is successful in the majority of cases, however, many survivors are left with lifelong severe neurocognitive and physical sequelae. Interestingly, the proteasome plays a vital role in the pathogenesis of different tumours, therefore proteasome inhibition can be used as a new strategy for treating MB. NPI-0052 is a proteasome inhibitor that can penetrate the blood-brain barrier with a good safety profile, making it an appealing treatment for brain tumors. In the present study, we evaluate the anticancer activity of NPI-0052 in a range of MB patient derived MB cells and cell lines. Our preclinical work demonstrated that NPI-0052 can inhibit proteasome activity and activate apoptosis in MB cells. We also show that the p53-family plays a substantial role in NPI-0052’s mechanism of action. Moreover, we observe that NPI-0052 has a synergistic apoptotic effect with gamma-radiation, a component of the current MB therapy, in both cells and tumour organoids. Our work underscores the use of NPI-0052 as a novel therapy for reducing the doses of gamma-radiation in G3-MB patients.
Functional Somatic and Germline Variants in the NF-κB Pathway in Chronic Lymphocytic Leukemia
Authors: Ma. Reina Improgo, Adam Kiezun, Yaoyu Wang, Lillian Werner, Petar Stojanov, Dan Landau, Carrie Sougnez, Bethany Tesar, Stacey M. Fernandes, Alexander R. Vartanov, Michael S. Lawrence, Kristian Cibulskis, Donna S. Neuberg, Catherine J. Wu, Gad Getz, Jennifer R. Brown
Journal: Blood (2012)
Subcutaneous Dosing of CRA-027483, a Small Molecule FVIIa Inhibitor, Prevents Arterial Thrombosis in a Baboon Model.
Authors: Ulla M. Marzec, Juthamas Sukbuntherng, Stacie A. Dalrymple, Wendy B. Young, Dange Vijaykumar, Peter R. Young, Stephen R. Hanson
Journal: Blood (2005)
Results of a Randomized, Open-Label, Phase IIIb Study of 2 Schedules of Decitabine in Higher-Risk Myelodysplastic Syndrome Patients
Authors: Depei Wu, Xin Du, Jie Jin, Zhijian Xiao, Zhixiang Shen, Zonghong Shao, Xiao Li, Xiaojun Huang, Ting Liu, Li Yu, Jianyong Li, Baoan Chen, Guangsheng He, Zhen Cai, Changgeng Ruan
Journal: Blood (2012)
Rare Genetic Variants Of The Protein-Coding Area Of The Genome and The Risk Of Inhibitor Development: An Exome-Sequencing Study Of 28 Patients With Severe Hemophilia A
Authors: Luca A. Lotta, Marco Fornili, Federico Ambrogi, Maria Elisa Mancuso, Elena Santagostino, Isabella Garagiola, Sabrina Seregni, Donna M. Muzny, Ginger Metcalf, Richard A. Gibbs, Elia Biganzoli, Flora Peyvandi
Journal: Blood (2013)
A Phase I Dose Expansion Cohort Study of the Safety, Pharmacokinetics and Pharmacodynamics of SAR245409 (S09), An Orally Administered PI3K/mTOR Inhibitor, in Patients with Lymphoma
Authors: Kyriakos P Papadopoulos, Pau Abrisqueta, Glenda Chambers, Drew Rasco, Amita Patnaik, Josep Tabernero, Kanya Rajangam, Kevin Rockich, Coumaran Egile, Adrianne Kelly, Yi Xu, Joanne Lager, Julie M Vose
Journal: Blood (2011)