Effect of Dapagliflozin in DAPA-HF According to Background Glucose-Lowering Therapy
Authors: Kieran F. Docherty, Pardeep S. Jhund, Olof Bengtsson, David L. DeMets, Silvio E. Inzucchi, Lars Køber, Mikhail N. Kosiborod, Anna Maria Langkilde, Felipe A. Martinez, Marc S. Sabatine, Mikaela Sjöstrand, Scott D. Solomon, John J.V. McMurray, Mirta Diez, Sonia Sassone, Diego Aizenberg, Maria Talavera, Guillermo Mercau, Diego Martinez, Juan Albisu, Alejandro Hershson, Rubén GarcíaDurán, Miguel Hominal, Natalia Cluigt, Fernando ColomboBerra, Eduardo Perna, Rodolfo AhuadGuerrero, Daniela GarcíaBrasca, Cesar Zaidman, Claudio Majul, José Taborda, Hugo Luquez, Jorgelina Sala, Alvaro SosaLiprandi, Guillermo Cursack, Oscar Montaña, AlbertoAlfredo Fernandez, Martín Najenson, Sebastian Nani, Gustavo Caruso, Enrique Fairman, Stella PereiroGonzalez, Lilia Maia, Adamastor Pereira, Paulo Rossi, Dalton Precoma, Fernando Neuenschwander, Gilmar Reis, Fabio Guimaraes, José Saraiva, Flavia Arantes, Mauro Hernandes, Joao Borges, Bruno Paolino, Eduardo Vasconcellos, Euler Manenti, Pedro Pimentel, Paulo Leaes, Salvador Rassi, Talia Dalcoquio, Tsvetana Katova, Danail Avramov, Nataliya Spasova, Dimitar Raev, Boryana Chompalova, Maria Milanova, Maria Tokmakova, Nikolai Runev, Atanas Mihov, Antoni Gogov, Adriana Dincheva, Nikolay Iliev, Borislav Kolomanov, Yuliyana Ivanova, Katya Ilieva, Dimitar Karageorgiev, Ivan Petrov, Nikolay Botushanov, Stefka Vladeva, Christian Constance, Saul Vizel, Amritanshu Pandey, Denis-Carl Phaneuf, Shamir Mehta, Dennis Rupka, Yves Pesant, Paul Poirier, Raja Chehayeb, Mohan Babapulle, Eileen O’Meara, Jonathan Howlett, Louis Yao, Robert McKelvie, Subodh Verma, Michael Hartleib, Ram Vijayaraghavan, John Vyselaar, Fabian Azzari, James Cha, Farah Nasser-Sharif, TunZan Maung, Samer Mansour, Yaariv Khaykin, Rina Lee, Peter Fong, Junbo Ge, Hong Jiang, Xinli Li, Lu Fu, Ying Li, Dongfang Wang, Qiang Zhao, Yugang Dong, Yimeng Zhou, Xiufang Lin, Jianzeng Dong, Xiaoli Zhang, Zeqi Zheng, Wenjun Huang, Ye Gu, Jinqiu Liu, Xueya Guo, Ling Wu, Qizhu Tang, Daoquan Peng, Wei Dong, Yingzi Liang, Daying Wang, Chun Wu, Zhanquan Li, Xuefeng Lin, Xuelian Zhang, Zhirong Wang, Bing Han, Jan Belohlavek, Josef Slaby, Jindrich Spinar, Petr Hajek, Ladislav Busak, Jiri Carda, Lenka Spinarova, Ivan Malek, Jiri Skopek, Roman Kuchar, Eva Krcova, Otto Mayer, Dusan Kucera, Morten Schou, Lars Køber, Kenneth Egstrup, JensDahlgaard Hove, Gunnar Gislason, Lars Videbæk, Michael Böhm, Ruth Nischik, Nicole Toursarkissian, Karl-Friedrich Appel, Ekkehard Schmidt, Ingo Weigmann, Monika Kellerer, Ayham Al-Zoebi, Uta Stephan, Andreas Wilke, Sabine Genth-Zotz, Gregor Simonis, Diethelm Tschöpe, Angelika Costard-Jäckle, Mark Petrie, Roy Gardner, Andrew Clark, Alan Japp, Pardeep Jhund, Chim Lang, Stephen Leslie, Clare Murphy, Colin Petrie, John Walsh, Béla Merkely, Péter Andrássy, Ebrahim Noori, Zoltán Járai, Ferenc Poór, Csaba Király, Anna Czigány, László Nagy, Ákos Motyovszki, Gabriella Masszi, Vimal Mehta, V Chopra, Ajay Naik, Milind Gadkari, Rahul Sawant, Mashhadi Mahapekar, Sunil Karna, Mukund Deshpande, Varun Bhargava, Veerappa Kothiwale, Jaideep Menon, Dhurjati Sinha, Santosh Sinha, Hemant Kokane, Prashant Udgire, Manjinder Sandhu, Masahiro Suzuki, Masami Nishino, Arihiro Kiyosue, Kotaro Sumii, Shu Suzuki, Yuichi Noguchi, Shinji Tanaka, Horoyuki Takase, Masahiro Mohri, Shinichi Higashiue, Noritaka Fujimoto, Harukazu Iseki, Takehiko Kuramochi, Taro Shibasaki, Hiroshi Tsutsui, Yuichiro Takagi, Satoru Sakuragi, Noriyuki Takeyasu, Masahumi Kitakaze, Chisato Izumi, Takafumi Oga, Akira Kimura, Tsunekazu Kakuta, Tetsuo Hashimoto, Hiroshi Sugino, Katsumi Saito, Shitoshi Hiroi, Haruo kamiya, Kazuki Fukui, Satoshi Matsuoka, Kazunori Moritani, Yoshiaki Tomobuchi, Yoshiki Hata, Ryo Kawamura, Eijiro Hattori, Kazuteru Fujimoto, Natsuki Takahashi, Wataru Takahashi, Toshiaki Kadokami, Hideki Ueno, Shinichiro Uchikawa, Tsuyoshi Shinozaki, Yuko Onishi, Nobuyuki Komiyama, Shujiro Inoue, Yukihiko Momiyama, Yasunori Ueda, Yasuo Komura, Ryo Hayashida, Seigo Masuda, Motoaki Higuchi, Yasushi Hayashi, Kozaburo Seki, Kenshi Fujii, Ken Harada, Atsuyuki Wada, Takatoshi Kasai, Koichiro Kuwahara, Shogo Oishi, Issei Uchida, Yasuo Okumura, Yuji Hisamatsu, Tatsuya Nunohiro, Kengo Tsukahara, Atsushi Hirohata, Masanori Asakura, Rudolf deBoer, Louise Bellersen, Henk Swart, Björn Groenemeijer, Stieneke ZoetNugteren, Cornelis(Ron) deNooijer, Pieter Nierop, Ramon RoblesdeMedina, Jacob(Martijn) vanEck, Maarten vanHessen, Jarosław Drożdż, Paweł Miękus, Ryszard Ściborski, Beata Mikłaszewicz, Wanda Sudnik, Rafał Mariankowski, Robert Witek, Grzegorz Drelich, Ewa Mirek-Bryniarska, Sławomir Szynal, Lidia Pawłowicz, Jacek Lampart, Romuald Korzeniak, Janusz Prokopczuk, Svetlana Boldueva, Yury Didenko, Nino Dzhaiani, Lyudmila Ermoshkina, Victor Kostenko, Elena Vishneva, Natalia Koziolova, Sergey Tereschenko, Dmitrii Pevzner, Liudmila Krylova, Alexander Chernyavsky, Andrei Kazakov, Sergei Aksentiev, Rostislav Nilk, Zhanna Paltsman, Albert Galyavich, Alexey Maltcev, Philipp Kopylov, Andrey Ezhov, Julia Shilko, Lubomir Antalik, Viliam Bugan, Peter Fulop, Livia Jamriskova, Daniela Kollarova, Vladimir Macek, Maria Slovenska, Livia Tomasova, Daniela Vinanska, Rudolf Smik, Juraj Selecky, Ivan Majercak, Peter Olexa, Charlotta Ljungman, Anders Hedman, Carl-Johan Lindholm, Krister Lindmark, Thomas Mooe, Chern Chiang, Lian-Yu Lin, Ming-En Liu, Kuan-Cheng Chang, Chien-Hsun Hsia, Jhih-Yuan Shih, Ping-Yen Liu, Tsung-Hsien Lin, Hung-Yu Chang, Jin-Long Huang, I-Chang Hsieh, Chih-Cheng Wu, Wei-Kung Tseng, Ahmed Arif, David Avino, Supratim Banerjee, Manreet Kanwar, Martin Berk, Christopher Brown, Carlos Ince, Todd Lewis, Akbar Nikfarjam, Jignesh Patel, Kodangudi Ramanathan, Alexander Schabauer, Trevor Greene, Keyur Shah, Rodolfo Sotolongo, Amado Viera, Olakunle Akinboboye, Amy Arouni, Barry Bertolet, Lokesh Chandra, Thomas Cimato, Samuel DeLeon, Mosi Bennett, Francesco Franchi, Glenn Hamroff, David Hotchkiss, Michael Jardula, Julian Javier, Navid Kazemi, John Kostis, Joseph Lash, Lawrence Levinson, Ira Lieber, Eric Lo, Sharan Mahal, Ramin Manshadi, Freny Mody, Alexander Paraschos, Michael Pursley, Gavin Hickey, Juan Londono, Dinesh Singal, Sunny Srivastava, Julie Teel, Jorge Castriz, Louis Kantaros, Chandra Venugopal, Cezar Staniloae, Dinesh Gupta, Faizullah Syed, Michael Zacharias, Naseem Jaffrani, Paul Wakefield, Mike Nassif, Tariq Haddad, Sherif Iskander, Gregory Lewis, Bassam Al-Joundi, William French, Modele Ogunniyi, Sitaramesh Emani, Sara Weiss, Richard Cheng, Viorel Florea, Susan Joseph, Deepak Gupta, Samuel Lederman, Joseph Izzo, Marc Bernstein, Erich Fruehling, Brian Foley, Liwa Younis, David Song, Vinh Pham, Hai Nguyen, Huan Do, Binh Truong, Hien Nguyen, Tuan Nguyen, Hien Nguyen, Dung Ho
Journal: Diabetes Care (2020)

OBJECTIVE To determine whether the benefits of dapagliflozin in patients with heart failure and reduced ejection fraction (HFrEF) and type 2 diabetes in the Dapagliflozin And Prevention of Adverse-Outcomes in Heart Failure trial (DAPA-HF) varied by background glucose-lowering therapy (GLT). RESEARCH DESIGN AND METHODS We examined the effect of study treatment by the use or not of GLT and by GLT classes and combinations. The primary outcome was a composite of worsening heart failure (hospitalization or urgent visit requiring intravenous therapy) or cardiovascular death. RESULTS In the 2,139 type 2 diabetes patients, the effect of dapagliflozin on the primary outcome was consistent by GLT use or no use (hazard ratio 0.72 [95% CI 0.58–0.88] vs. 0.86 [0.60–1.23]; interaction P = 0.39) and across GLT classes. CONCLUSIONS In DAPA-HF, dapagliflozin improved outcomes irrespective of use or no use of GLT or by GLT type used in patients with type 2 diabetes and HFrEF.