tbuckley/cabot-search huggingface dataset:
Remission and Survival after Single Versus Double Induction with 7+3 for Newly Diagnosed Acute Myeloid Leukemia: Results from the Planned Interim Analysis of Randomized Controlled SAL-Daunodouble Trial
Authors: Christoph Röllig, Björn Steffen, Nael Alakel, Regina Herbst, Richard Noppeney, Maher Hanoun, Zdenek Racil, Kerstin Schäfer-Eckart, Alwin Krämer, Andreas Neubauer, Claudia D Baldus, Christoph Schliemann, Martin Kaufmann, Jolana Mertova, Edgar Jost, Dirk Niemann, Jan Novak, Stefan W Krause, Sebastian Scholl, Gerhard Held, Stefani B. Parmentier, Tomáš Szotkowski, Pavel Zak, Andreas Rank, Maxi Wass, Sebastian Buske, Michael Kramer, Frank Fiebig, Annett Haake, Johannes Schetelig, Uwe Platzbecker, Christian Thiede, Carsten Müller-Tidow, Wolfgang E. Berdel, Hubert Serve, Gerhard Ehninger, Jiri Mayer, Martin Bornhäuser
Journal: Blood (2020)
Combined Genetic Lesions in TP53 and CDKN2A/CDKN2B Drive B Cell Receptor-Dependent/Costimulatory Signal-Independent Proliferation in Richter Syndrome
Authors: Supriya Chakraborty, Claudio Martines, Fabiola Porro, Ilaria Fortunati, Alice Bonato, Marija Dimishkovska, Brijesh Yadav, Idanna Innocenti, Rosa Fazio, Tizianna Vaisitti, Silvia Deaglio, Alberto Zamò, Aleksandar Dimovski, Luca Laurenti, Dimitar G Efremov
Journal: Blood (2020)
Hematologic Predictors of Outcomes in Patients Undergoing Intensive Induction Chemotherapy for Newly Diagnosed Acute Myeloid Leukemia
Authors: Saad Arain, Eshana Shah, Betul Gok Yavuz, Sarah Stettner, Gregory Sampang Calip, Irum Khan, Pritesh Patel, John G. Quigley
Journal: Blood (2020)
TWIST1 Preserves Hematopoietic Stem Cell Function Via Repression of Cacna1b Expression
Authors: Nan Wang, Jing Yin, Na You, Dan Guo, Yangyang Zhao, Yongxin Ru, Xiaoyan Liu, Hui Cheng, Qian Ren, Tao Cheng, Xiao-Tong Ma
Journal: Blood (2020)
Thrombin-Induced Endothelial Cell Damage Is Mitigated By Human Anti-Thrombin III in a Microfluidic Device
Authors: William Wulftange, Erdem Kucukal, Yuncheng Man, Ran An, Karamoja Monchamp, Olabimpe Olayiwola, Jane A. Little, Nigel S. Key, Umut A. Gurkan
Journal: Blood (2020)
Sustained Reductions in Red Blood Cell (RBC) Transfusion Burden and Events in β-Thalassemia with Luspatercept: Longitudinal Results of the Believe Trial
Authors: Ali T. Taher, Vip Viprakasit, Olivier Hermine, John B. Porter, Antonio Piga, Kevin H.M. Kuo, Thomas D. Coates, Ersi Voskaridou, Abderrahim Khelif, Antonis Kattamis, Jeevan K. Shetty, George Zhang, Yu (Olivia) Tian, Dimana Miteva, Tatiana Zinger, Derek Tang, Jay T. Backstrom, Maria Domenica Cappellini
Journal: Blood (2020)
Immunogenomics of Paroxysmal Nocturnal Hemoglobinuria: A Model of Immune Escape
Authors: Carmelo Gurnari, Simona Pagliuca, Cassandra M Kerr, Hassan Awada, Sunisa Kongkiatkamon, Laila Terkawi, Neetha Parameswaran, Misam Zawit, Adam Wahida, Valeria Visconte, Jaroslaw P. Maciejewski
Journal: Blood (2020)
Pain and Opioid Use in Patients with FLT3 Mutation-Positive Relapsed/Refractory AML: A Subanalysis of Patient-Reported Outcomes from the Admiral Trial
Authors: David Cella, Ellen Ritchie, Arnaud Pigneux, Yoshinobu Kanda, Cristina Ivanescu, Bhavik J. Pandya, Manasee V. Shah
Journal: Blood (2020)
Characteristics of <i>in Vitro</i> Differentiated Erythrocytes Derived from Human <i>Bmi-1</i> Extensively Expanded Erythroblasts (E3)
Authors: Moira M. Lancelot, Natia Saakadze, Jiusheng Deng, Sean R. Stowell, Ryan Jajosky, Linzhao Cheng, Senquan Liu, John D Roback
Journal: Blood (2020)
THU0133 New approaches in diagnosis of sensor polyneuropathy in rheumatoid arthritis
Authors: BF Nemtsov, LA Smirnova, OV Simonova
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> Investigation of vibration perception disorders is a required method for diagnosis of sensor polyneuropathy (SPNP) in case of diabetes mellitus. SPNP is one of the most frequent extraarticular symptoms of rheumatoid arthritis (RA). <h3>Objectives</h3> To develop and introduce a new express diagnostic method for SPNP in RA into clinical practice. <h3>Methods</h3> 91 RA patients were studied. Of them, 91% were females and 9% were males. The majority of patients had a severe form of RA. 49% had extraarticular symptoms. SPNP was studied by means of measuring of vibration perception. The biothesiometer of the EG-Electronic Company was used. Lower extremities were investigated. In addition to that electroneuromyography (ENMG) was performed. <h3>Results</h3> In more severe forms of RA the vibration perception considerably increased (p &lt; 0.01). In the patients with extraarticular symptoms the above disorder was more severe and more frequent as compared with the patients who had no extraarticular symptoms (p &lt; 0.0001). Comparison of the two diagnostic methods showed that ENMG and biothesiometry enable to diagnose SPNP with the same frequency (80% and 77% relatively). <h3>Conclusion</h3> Thus, investigation of vibration perception is as effective as the routine ENMG. This is a painless fast express method. This new method enables to diagnose extraarticular symptoms in RA very quickly. It can be used as an additional evaluation criterion of RA severity.
Cap-and-suction hemoclip closure of an iatrogenic cricopharyngeal perforation
Authors: Michiel Bronswijk, Philip Roelandt
Journal: Endoscopy (2020)

Over-the-scope (OTS) clips have revolutionized the management of gastrointestinal (GI) perforations and leaks [1] [2] [3] [4]. However, the dimensions of the OTS clip and its delivery device can make deployment challenging or even undesirable [5], especially in regions of the GI tract where maneuverability may be limited.
Single-Cell Transcriptomic Heterogeneity in Invasive Ductal and Lobular Breast Cancer Cells
Authors: Fangyuan Chen, Kai Ding, Nolan Priedigkeit, Ashuvinee Elangovan, Kevin M. Levine, Neil Carleton, Laura Savariau, Jennifer M. Atkinson, Steffi Oesterreich, Adrian V. Lee
Journal: Cancer Research (2020)

Invasive lobular breast carcinoma (ILC), one of the major breast cancer histologic subtypes, exhibits unique features compared with the well-studied ductal cancer subtype (IDC). The pathognomonic feature of ILC is loss of E-cadherin, mainly caused by inactivating mutations, but the contribution of this genetic alteration to ILC-specific molecular characteristics remains largely understudied. To profile these features transcriptionally, we conducted single-cell RNA sequencing on a panel of IDC and ILC cell lines, and an IDC cell line (T47D) with CRISPR-Cas9-mediated E-cadherin knockout (KO). Inspection of intracell line heterogeneity illustrated genetically and transcriptionally distinct subpopulations in multiple cell lines and highlighted rare populations of MCF7 cells highly expressing an apoptosis-related signature, positively correlated with a preadaptation signature to estrogen deprivation. Investigation of E-cadherin KO-induced alterations showed transcriptomic membranous systems remodeling, elevated resemblance to ILCs in regulon activation, and increased sensitivity to IFNγ-mediated growth inhibition via activation of IRF1. This study reveals single-cell transcriptional heterogeneity in breast cancer cell lines and provides a resource to identify drivers of cancer progression and drug resistance. SIGNIFICANCE: This study represents a key step towards understanding heterogeneity in cancer cell lines and the role of E-cadherin depletion in contributing to the molecular features of invasive lobular breast carcinoma.
Treatment of Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Using Tyrosine Kinase Inhibitors in Combination with Chemotherapy: A Patient-Centered Benefit-Risk Assessment
Authors: Ajibade O Ashaye, Caitlin Thomas, Mehul Dalal, Vamsi Kota, Nicolas Krucien, Maria Sae-Hau, Meredith Barnhart, Elisa S. Weiss, Scott Campbell, Kevin Marsh
Journal: Blood (2020)
Low Level <i>BCR-ABL1 G</i>ene Fusion Detected By RT-PCR in Newly Diagnosed Childhood Acute Lymphoblastic Leukemia Does Not Predict Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia at Relapse: A 10-Year Single Institution Study
Authors: Lucy E Cain, Oksana Mirochnik, Michael M Stevens, Stewart J Kellie, Bhavna Padhye, Steven J Keogh, Dinisha Govender, Jessica Ryan, Luciano Dalla-Pozza, Caroline M Bateman
Journal: Blood (2020)
Fedratinib, an Oral, Selective Inhibitor of Janus Kinase 2 (JAK2), in Patients with Intermediate-2 or High-Risk Myelofibrosis (MF): Updated Results from the Randomized, Placebo-Controlled, Phase III JAKARTA Trial
Authors: Animesh Pardanani, Ayalew Tefferi, Tamas Masszi, Elena Mishchenko, Mark W. Drummond, Eric Jourdan, Alessandro M. Vannucchi, Mindaugas Jurgutis, Vincent Ribrag, Alessandro Rambaldi, Liang Piu Koh, Shelonitda Rose, Jun Zhang, Claire Harrison
Journal: Blood (2020)
Co-Inhibition of IL-2, IL-9 and IL-15 By the Novel Immunomodulator, Bnz-1, Provides Clinical Efficacy in Patients with Refractory Cutaneous T Cell Lymphoma in a Phase 1/2 Clinical Trial
Authors: Christiane Querfeld, Basem M. William, Lubomir Sokol, Oleg Akilov, Brian Poligone, Jasmine Zain, Yutaka Tagaya, Nazli Azimi
Journal: Blood (2020)
Successful and Safe Treatment of Intestinal Graft-Versus-Host Disease (GvHD) with Pooled-Donor Full Ecosystem Microbiota Biotherapeutic: Results from a 29 Patient-Cohort of a Compassionate Use/Expanded Access Treatment Program
Authors: Florent Malard, Michael Loschi, Faezeh Legrand, Raynier Devillier, Sarah Guenounou, Cecile Borel, Deborah Desmier, Jérôme Cornillon, Amandine Le Bourgeois, Jean-Baptiste Mear, Delphine Martineau, Hélène Labussière, Marie-Anne Couturier, Claude-Eric Bulabois, Emilie Plantamura, Mohamad Mohty
Journal: Blood (2020)
Brentuximab Vedotin with Chemotherapy in Frontline Treatment of Classic Hodgkin Lymphoma Nodular Sclerosis Syncytial Variant
Authors: Raphael Eric Steiner, Melody R. Becnel, Branko Cuglievan, Ranjit Nair, Prachee Singh, Paolo Strati, Preetesh Jain, Sairah Ahmed, Felipe Samaniego, Jillian R. Gunther, Chelsea C. Pinnix, Penny Fang, Bouthaina S. Dabaja, Lei Feng, Hun Ju Lee
Journal: Blood (2020)
Molecular Epidemiology of AML: Association of Somatic Gene Mutations with Epidemiologic Exposures and Outcomes in the Mayo Clinic AML Epidemiology Cohort
Authors: Zaid Abdel Rahman, Yesesri Cherukuri, Michael G. Heckman, Laura E. Finn, Liuyan Jiang, Lisa Z. Sproat, James R. Cerhan, Yan Asmann, James M. Foran
Journal: Blood (2020)
10-Year Real-World Data on Acute Myeloid Leukemia: The Paradigm of a Public Health Center in Brazil
Authors: Camilla C. Campos, Lorena M. Caldas, Lais T. Silva, Monica Botura, Alessandro de M. Almeida, Ana Luzia Schriefer, Maria da Gloria B. Arruda, Marco Aurelio Salvino
Journal: Blood (2020)
Local Review Versus (vs) Central Review of Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) in Diffuse Large B-Cell Lymphoma (DLBCL): Results from the CALGB 50303 Trial [Alliance]
Authors: Amy S. Ruppert, Levi D. Pederson, Michael V. Knopp, David Poon, Jun Zhang, Brad S. Kahl, Jonathan W. Friedberg, Lawrence H. Schwartz, Wyndham H. Wilson, John P. Leonard, Nancy L. Bartlett, Heiko Schöder
Journal: Blood (2020)
Defective lysosome reformation during autophagy causes skeletal muscle disease
Authors: Meagan J. McGrath, Matthew J. Eramo, Rajendra Gurung, Absorn Sriratana, Stefan M. Gehrig, Gordon S. Lynch, Sonia Raveena Lourdes, Frank Koentgen, Sandra J. Feeney, Michael Lazarou, Catriona A. McLean, Christina A. Mitchell
Journal: Journal of Clinical Investigation (2020)

The regulation of autophagy-dependent lysosome homeostasis in vivo is unclear. We showed that the inositol polyphosphate 5-phosphatase INPP5K regulates autophagic lysosome reformation (ALR), a lysosome recycling pathway, in muscle. INPP5K hydrolyzes phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] to phosphatidylinositol 4-phosphate [PI(4)P], and INPP5K mutations cause muscular dystrophy by unknown mechanisms. We report that loss of INPP5K in muscle caused severe disease, autophagy inhibition, and lysosome depletion. Reduced PI(4,5)P2 turnover on autolysosomes in Inpp5k-/- muscle suppressed autophagy and lysosome repopulation via ALR inhibition. Defective ALR in Inpp5k-/- myoblasts was characterized by enlarged autolysosomes and the persistence of hyperextended reformation tubules, structures that participate in membrane recycling to form lysosomes. Reduced disengagement of the PI(4,5)P2 effector clathrin was observed on reformation tubules, which we propose interfered with ALR completion. Inhibition of PI(4,5)P2 synthesis or expression of WT INPP5K but not INPP5K disease mutants in INPP5K-depleted myoblasts restored lysosomal homeostasis. Therefore, bidirectional interconversion of PI(4)P/PI(4,5)P2 on autolysosomes was integral to lysosome replenishment and autophagy function in muscle. Activation of TFEB-dependent de novo lysosome biogenesis did not compensate for loss of ALR in Inpp5k-/- muscle, revealing a dependence on this lysosome recycling pathway. Therefore, in muscle, ALR is indispensable for lysosome homeostasis during autophagy and when defective is associated with muscular dystrophy.
COVID-19 Impact on Lymphoma Patients' Clinical Outcomes - an Observational Cohort Study
Authors: Andrew Ip, Anthony Mato, Jordan Intrator, Nicholas P Howard, Alessandra Petrillo, Rosalba Vicioso, Rani Sebti, Cristina Cicogna, Gabriella Magarelli, Lori A. Leslie, Andre H. Goy, Tatyana A. Feldman
Journal: Blood (2020)
Correction: Is there a link between very early changes of primary and secondary lymphoid organs in 18F-FDG-PET/MRI and treatment response to checkpoint inhibitor therapy?
Authors: Yuan Chen, Zhibin Xie, Kehan Song, Zhi-Ying Zhan, Yi Yao, Hongyun Gong, Qun Wang, Xiaorong Dong, Chun-Quan Ou, Qinyong Hu
Journal: Journal for ImmunoTherapy of Cancer (2020)
Hepatic Fibrosis Associates With Multiple Cardiometabolic Disease Risk Factors: The Framingham Heart Study
Authors: Michelle T. Long, Xiaoyu Zhang, Hanfei Xu, Ching‐Ti Liu, Kathleen E. Corey, Raymond T. Chung, Rohit Loomba, Emelia J. Benjamin
Journal: Hepatology (2020)

Background and Aims NAFLD is increasing in prevalence and will soon be the most common chronic liver disease. Liver stiffness, as assessed by vibration‐controlled transient elastography (VCTE), correlates with hepatic fibrosis, an important predictor of liver‐related and all‐cause mortality. Although liver fat is associated with cardiovascular risk factors, the association between hepatic fibrosis and cardiovascular risk factors is less clear. Approach and Results We performed VCTE, assessing controlled attenuation parameter (CAP; measure of steatosis) and liver stiffness measurement (LSM) in 3,276 Framingham Heart Study adult participants (53.9% women, mean age 54.3 ± 9.1 years) presenting for a routine study visit. We performed multivariable‐adjusted logistic regression models to determine the association between LSM and obesity‐related, vascular‐related, glucose‐related, and cholesterol‐related cardiovascular risk factors. The prevalence of hepatic steatosis (CAP ≥ 290 dB/m) was 28.8%, and 8.8% had hepatic fibrosis (LSM ≥ 8.2 kPa). Hepatic fibrosis was associated with multiple cardiovascular risk factors, including increased odds of obesity (OR, 1.82; 95% CI, 1.35‐2.47), metabolic syndrome (OR, 1.49; 95% CI 1.10‐2.01), diabetes (OR, 2.67; 95% CI, 1.21‐3.75), hypertension (OR, 1.52; 95% CI, 1.15‐1.99), and low high‐density lipoprotein cholesterol (OR, 1.47; 95% CI, 1.09‐1.98), after adjustment for age, sex, smoking status, alcohol drinks/week, physical activity index, aminotransferases, and CAP. Conclusions In our community‐based cohort, VCTE‐defined hepatic fibrosis was associated with multiple cardiovascular risk factors, including obesity, metabolic syndrome, diabetes, hypertension, and high‐density lipoprotein cholesterol, even after accounting for covariates and CAP. Additional longitudinal studies are needed to determine if hepatic fibrosis contributes to incident cardiovascular disease risk factors or events.
High-Risk Population Screening for Gaucher Disease: Final Results and Key Learnings from an Italian Multicenter Observational Study
Authors: Irene Motta, Christian Benedetto, Marina Stroppiano, Elena Cassinerio, Dario Consonni, Lorenza Borin, Paola Ranalli, Wilma Barcellini, Maria Domenica Cappellini
Journal: Blood (2020)
The Incidence of Mastocytosis in Patients with Unclear Cytopenia and/or Leucocytosis: The Hryd Study
Authors: Hannah Seemann, Nadja Jaekel, Susann Schulze, Juliane Grimm, Ole Vollstaedt, Anja Haak, Dietger Niederwieser, Claudia Wickenhauser, Haifa Kathrin Al-Ali
Journal: Blood (2020)
AB0133 Blue coloured skin in psoriatic arthritis
Authors: I Jajic, Z Jajiæ, T Nemcic
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> <h3>Objectives</h3> In this paper, we have analysed blue coloured skin over involved joints as a one of the clinical features of the psoriatic arthritis that is helpful for simpler and earlier reaching the diagnosis. <h3>Methods</h3> Clinical material consisted of 650 consecutively hospitalised and outdepartment patients with the diagnosis of PsA and 1265 patients with diagnosis of RA in period between 1975 and 1998 year. Special attention was attended to inspection of the skin over involved joint including skin appearance, colour and size of the involved area and its changes in different conditions of the weather and temperature. <h3>Results</h3> We have found blue coloured skin over involved joints in 598 patients with PsA (92%) and in 63 patients with RA (5%) (N2 joints and digits in case of sausage digits. In less involved joints blue colour develops in minor area, usually on central dorsal part of the sin over the joint. Blue coloured skin was better visible in the cold winter days while in the summer season and during the remission of the disease as well as at room temperature, blue colour is less marked or even disappears. <h3>Conclusion</h3> This sign is reliable, so it should be very useful in PsA diagnostics.
<i>ASXL1</i> Mutations Predict a Poor Response to Darbepoetin Alfa in Anemic Patients with Low-Risk MDS: A Multicenter, Phase II Study
Authors: Hitoshi Hanamoto, Yasuyoshi Morita, Motoshi Ichikawa, Yasuhito Nannya, Hirohiko Shibayama, Yoshinobu Maeda, Tomoko Hata, Toshihiro Miyamoto, Hiroshi Kawabata, Kazuto Takeuchi, Hiroko Tanaka, Junji Kishimoto, Satoru Miyano, Itaru Matsumura, Seishi Ogawa, Koichi Akashi, Yuzuru Kanakura, Kinuko Mitani
Journal: Blood (2020)
Results of Genetic Analysis of 11,341 Participants Enrolled in the <i>My Life, Our Future</i> (MLOF) Hemophilia Genotyping Initiative
Authors: Jill M Johnsen, Shelley N Fletcher, Angela Dove, Haley McCracken, Beth K Martin, Martin Kircher, Neil C Josephson, Jay Shendure, Sarah Ruuska, Leonard A. Valentino, Glenn Pierce, Crystal Watson, Dunlei Cheng, Michael Recht, Barbara A. Konkle
Journal: Blood (2020)
The predicting role of circulating tumor DNA landscape in gastric cancer patients treated with immune checkpoint inhibitors
Authors: Ying Jin, Dong-Liang Chen, Feng Wang, Chao-pin Yang, Xu-Xian Chen, Jin-qi You, Jin-Sheng Huang, Yang Shao, Dong-Qin Zhu, Yu-Ming Ouyang, Hui-Yan Luo, Zhi-Qiang Wang, Feng-Hua Wang, Yu-Hong Li, Rui-Hua Xu, Dong-Sheng Zhang
Journal: Molecular Cancer (2020)

A more common and noninvasive predicting biomarker for programmed cell death 1 (PD-1) antibody remains to be explored. We assessed 46 patients with advanced gastric cancer who received PD-1 antibody immunotherapy and 425-genes next-generation sequencing (NGS) testing. Patients who had a > 25% decline in maximal somatic variant allelic frequency (maxVAF) had a longer progression free survival (PFS) and higher response rate than those who did not (7.3 months vs 3.6 months, p = 0.0011; 53.3% vs 13.3%, p = 0.06). The median PFS of patients with undetectable and detectable post-treatment circulating tumor DNA (ctDNA) was 7.4 months vs. 4.9 months (p = 0.025). Mutation status of TGFBR2, RHOA, and PREX2 in baseline ctDNA influenced the PFS of immunotherapy (p < 0.05). Patients with alterations in CEBPA, FGFR4, MET or KMT2B (p = 0.09) gene had greater likelihood of immune-related adverse events (irAEs). ctDNA can serve as a potential biomarker of the response to immunotherapy in advanced gastric cancers, and its potential role in predicting irAEs worth further exploration.
Influence of Aging Processes on the Biology and Outcome of Multiple Myeloma
Authors: Eileen M Boyle, Louis Williams, Patrick Blaney, Cody Ashby, Michael A Bauer, Brian A Walker, Jinyoung Choi, Jessica Caro, Beatrice Razzo, Arnaldo A. Arbini, David Kaminetzky, Marc Braunstein, Francesco Maura, Yubao Wang, Ola Landgren, James Stoeckle, Kylee H Maclachlan, Rachel Litke, Faith E. Davies, Gareth Morgan
Journal: Blood (2020)
Abstract 532: Isolation of Human Placenta-derived Cdx2 Cells for Cardiac Regeneration
Authors: Sangeetha Vadakke-Madathil, Fumiko Dekio, Rhoda Sperling, Rachel Brody, Angela Bianco, Hina Chaudhry
Journal: Circulation Research (2020)

Coronary artery disease and heart failure are among the leading causes of mortality in United States and worldwide. The limited proliferation of the adult mammalian heart has prompted the need to recognize novel strategies that can restore contractile function in heart disease. We recently reported that cells expressing trophoblast marker Cdx2 isolated from murine end-gestation placentas are multipotent and immune-privileged, with homing ability to travel to sites of cardiac injury to regenerate injured myocardium. Since murine Cdx2 cells are immunologically naïve and trophoblast-mediated placentation is a conserved phenomenon, our findings are ripe for translational application. Here we demonstrate the expression of CDX2 and isolation of CDX2 cells from human term placentas highlighting a potentially critical cell source for allogeneic therapy for cardiac regeneration. We studied de-identified human term placenta tissues from three different anatomical sites from three different patients. Formalin-fixed paraffin embedded samples, second trimester chorionic villus samples and de-identified fresh chorion samples were utilized. Using a multiparametric approach including transcript analysis and Sanger sequencing, immunoblot and immunofluorescence analysis, with the subsequent screening of different anatomical sites, we observed that CDX2 is present in the chorionic (fetal cytotrophoblast) portion of human term placentas including the chorionic villous samples (CVS). Subsequent validation on positive control cells DLD1 (human colon carcinoma cell line), versus HeLa cells (low endogenous CDX2 expression) was performed. Visualization of CDX2 expression showed the nuclear localization in the villi region. We have further demonstrated using a CDX2 promoter-driven fluorescence-based lentiviral expression system, we can isolate viable CDX2 cells from fresh term placenta. We demonstrate for the first time that CDX2 cells are present and can be isolated from term human placentas for prospective cardiomyocgenic differentiation. A step closer to the translational approach, our results herein may represent a paradigmatic shift in the way we approach early embryonic lineages and cell fate choices towards the identification of an unexplored human cell-based approach for cardiac regeneration.