COVID-19 in a patient with severe chronic rhinosinusitis with nasal polyps during therapy with dupilumab
Authors: Ulrike Förster-Ruhrmann, Agnieszka J. Szczepek, Claus Bachert, Heidi Olze
Journal: Journal of Allergy and Clinical Immunology (2020)

mAbs (biologics) such as dupilumab, a fully human mAb blocking IL-4 and IL-13 signaling, started recently to be successfully used also for the treatment of severe forms of chronic rhinosinusitis with nasal polyps (CRSwNP).1Bachert C. Han J.K. Desrosiers M. Hellings P.W. Amin N. Lee S.E. et al.Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials.Lancet. 2019; 394: 1638-1650Abstract Full Text Full Text PDF PubMed Scopus (863) Google Scholar Currently, no data are available on whether the therapy with dupilumab influences the risk of infection with the coronavirus (severe acute respiratory disease coronavirus 2 [SARS-CoV-2]) or whether it modulates the course of coronavirus disease 2019 (COVID-19). Here, we report a case of a 53-year-old female patient (body mass index, 23.5) treated with dupilumab for uncontrolled severe CRSwNP, who developed COVID-19. Twenty years ago, the patient consulted her physician because of rhinitis, which was consecutively diagnosed as CRSwNP. At that time, she also developed asthma, and in 2005, reported respiratory symptoms following intake of 2 different nonsteroidal anti-inflammatory drugs. No further diagnostic tests were performed. Despite the administration of oral prednisolone 3 times a year, the regrowing nasal polyps had to be surgically removed in 2012, 2016, and 2019. She was receiving prednisolone because of recurrent documented nasal polyps extending beyond the middle nasal passage on both sides (Davos score 4 NP, a sum of both sides). The last course of prednisolone was administered in January 2020. In February 2020, the patient was admitted to our outpatient department for possible alternative treatment and was offered therapy with dupilumab for uncontrolled CRSwNP. Also, she was administered mometasone furoate 400 μg/d, fluticasone/salmeterol 250/50 μg 2 inhalations orally twice a day, 12 hours apart, and salbutamol when needed. The following set of clinical tests used in our clinic as a standard to characterize the patients with CRSwNP was applied:•Rhinological parameters: Nasal endoscopy Davos score—score 1: NP in middle meatus only; score 2: NP beyond middle meatus; score 3: NP not blocking the nose completely; score 4: NP completely obstructing the nose; a sum of both nasal sides.•Pulmonary parameters: The Asthma Control Test (ACT) score, with ACT score 20 or more as controlled asthma, ACT score less than 20 as uncontrolled asthma,2Nathan R.A. Sorkness C.A. Kosinski M. Schatz M. Li J.T. Marcus P. et al.Development of the asthma control test: a survey for assessing asthma control.J Allergy Clin Immunol. 2004; 113: 59-65Abstract Full Text Full Text PDF PubMed Scopus (2243) Google Scholar and FEV1 and forced vital capacity (FVC) values of spirometric measurements.•Validated rhinological questionnaires: CRS Symptoms Score 0: no symptoms; 1: mild symptoms; 2: moderate symptoms; 3: severe symptoms1Bachert C. Han J.K. Desrosiers M. Hellings P.W. Amin N. Lee S.E. et al.Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials.Lancet. 2019; 394: 1638-1650Abstract Full Text Full Text PDF PubMed Scopus (863) Google Scholar; 22-item Sino-Nasal Outcome Test (SNOT-22) with 22 questions, each scored 0 to 5 (total score range, 0-110), with higher scores representing worse quality of life.3Hopkins C. Gillett S. Slack R. Lund V.J. Browne J.P. Psychometric validity of the 22-item Sinonasal Outcome Test.Clin Otolaryngol. 2009; 34: 447-454Crossref PubMed Scopus (1154) Google Scholar At presentation, the pulmonary parameters of the patient were FEV1/FVC ratio 62%; FEV1 57%; ACT score 16 (see Table I). Dupilumab (300 mg) was administered on February 24, 2020, in the outpatient ward of the Department of Otorhinolaryngology. The subcutaneous injections with dupilumab were continued on March 8 and 30, 2020, by self-application. Smell impairment, runny nose, and postnasal drip disappeared within 2 weeks from the therapy onset, and the nasal congestion kept improving. The SNOT-22 score decreased from 38 to 8. Between 11 and 15 March, the patient went on a trip with her husband (Table II). On March 14, she reported a return of anosmia while her husband (50 years old, body mass index, 31.6) developed fever, cough, and shortness of breath. Two days later, the patient, too, developed a fever and later cough. The SNOT-22 score increased to 24. On March 16, based on a viral PCR test, the patient and her husband were diagnosed with COVID-19 and were quarantined at home for 2 weeks. The patient continued the treatment with dupilumab by self-injection. Two weeks after the COVID-19 diagnosis, the patient and her husband were entirely relieved from the COVID-19 symptoms. The administration of dupilumab continued at home on March 22, 2020. During the telephone interview on March 30, 2020, the patient reported complete control of nasal polyp symptoms, normosmia, and a low SNOT-22 score.Table IRhinologic and pulmonary parameters before and during therapy with dupilumab: Symptoms during and after COVID-19ParameterTimelineFebruary 24, 2020Dupilumabinjection300 mg SCMarch 8, 2020Dupilumabinjection300 mg SCMarch 14, 2020toMarch 22, 2020COVID-19symptomsMarch 22, 2020Dupilumabinjection300 mg SCMarch 30, 2020Additional telephoneconsultationApril 22, 2020Outpatient department appointmentSmell Identification Test5/16 (anosmia)Not measuredNot measuredNot measuredNot measuredNot measuredCRS symptoms Nasal congestion321100 Smell impairment303000 Runny nose200000 Postnasal drip200000 SNOT-22 score38824974 ACT Score162525252525SC, Subcutaneous.Score of CRS symptoms: 0: no symptoms; 1: mild symptoms; 2: moderate symptoms; 3: severe symptoms. Open table in a new tab Table IIThe dynamics of COVID-19 symptoms development by the patient receiving dupilumab and her husbandCOVID-19-related eventsDateDupilumab patient (53 y)Patient's husband (50 y)March 11, 2020, to March 12, 2020Visiting BarcelonaMarch 12, 2020, to Macrh 15, 2020Visiting LisbonCOVID-19 symptomsMarch 14, 2020Onset of smell impairmentOnset of cough, shortness of breathMarch 14, 2020onset of fever (axillary measurement, 38.0°C)March 16-19, 2020Onset of fever (axillary measurement, 38.0°C)Use of antipyreticsParacetamol 500 mg oralParacetamol 500 mg and ibuprofen 400 mg oralMatch 14-18, 2020HeadacheMarch 17-22, 2020CoughCOVID-19 viral PCR test (nasal swabs taken by the family physician)March 16, 2020COVID-19-PCR-test result positiveCOVID-19-PCR-test result positiveCOVID-19 viral PCR test (nasal swabs taken by the outpatient physician)March 22, 2020COVID-19-PCR-test result negativeCOVID-19-PCR-test result negative Open table in a new tab SC, Subcutaneous. Score of CRS symptoms: 0: no symptoms; 1: mild symptoms; 2: moderate symptoms; 3: severe symptoms. To summarize, our patient with CRSwNP treated with dupilumab had an unexpectedly light course of COVID-19 (Table II). A few possible reasons might explain that. The first reason for the observed clinical course of COVID-19 in our patient could be that ongoing therapy with dupilumab already after a short time controlled the CRSwNP symptoms by reducing local inflammation and improving nasal respiration. Improvement in sinonasal function could be essential for the initial combating of COVID-19. Before therapy with dupilumab, our patient had poorly controlled asthma. Already after the second injection, she shifted into controlled asthma. Similarly, her nasal symptoms (eg, nasal congestion) improved, positively affecting the upper respiratory tract. The second reason for the light course of COVID-19 might be the recently described negative association between an increased number of eosinophils and the viral load.4Liu F. Xu A. Zhang Y. Xuan W. Yan T. Pan K. et al.Patients of COVID-19 may benefit from sustained lopinavir-combined regimen and the increase of eosinophil may predict the outcome of COVID-19 progression.Int J Infect Dis. 2020; 95: 183-191Abstract Full Text Full Text PDF PubMed Scopus (251) Google Scholar Such an increase was indeed seen in our patient (see Table E1 in this article's Online Repository at www.jacionline.org), corroborating the observations made during clinical trials with dupilumab.5Wollenberg A. Beck L.A. Blauvelt A. Simpson E.L. Chen Z. Chen Q. et al.Laboratory safety of dupilumab in moderate-to-severe atopic dermatitis: results from three phase III trials (LIBERTY AD SOLO 1, LIBERTY AD SOLO 2, LIBERTY AD CHRONOS).Br J Dermatol. 2020; 182: 1120-1135Crossref PubMed Scopus (95) Google Scholar The third possible reason for the uneventful COVID-19 could be that the initial viral load of SARS-CoV-2 was rather low upon infection, and the disease course was not associated with the dupilumab treatment. Finally, the direct positive effect of dupilumab on COVID-19 cannot be excluded, because it modulates immunity by affecting the TH2-type immune responses. It is tempting to speculate that this type of modulation might be beneficial to combat COVID-19, which is supported by higher levels of IL-4 associating with a fatal disease.6Li C.K. Wu H. Yan H. Ma S. Wang L. Zhang M. et al.T cell responses to whole SARS coronavirus in humans.J Immunol (Baltimore, Md : 1950). 2008; 181: 5490-5500Crossref PubMed Scopus (390) Google Scholar However, our patient received dupilumab for only a short period before infection, while observations made during clinical trials indicated that the full effect of dupilumab on the immune system occurs later.1Bachert C. Han J.K. Desrosiers M. Hellings P.W. Amin N. Lee S.E. et al.Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials.Lancet. 2019; 394: 1638-1650Abstract Full Text Full Text PDF PubMed Scopus (863) Google Scholar The continuation of dupilumab treatment during the infection with SARS-CoV-2 is in agreement with our own clinical experience and with the current recommendations of the German Society for Allergology and Clinical Immunology7DGAKIStatement of the German Society for Allergology and Clinical immunology (DGAKI) dated March 20, 2020 on the active substances: omalizumab, mepolizumab, reslizumab, benralizumab and dupilumab 2020.https://dgaki.de/wp-content/uploads/2020/03/Empfehlungen-der-DGAKI-zur-Biologikatherapie-und-COVID-19-3-2020.pdfGoogle Scholar about the continuation of the biologics treatment for severe CRSwNP. Interruption of therapy could lead to the progression of rhinosinusitis, expansion of polyp formation, and worsening of common comorbidities such as asthma. That, in turn, could negatively impact the course of COVID-19 and increase the spread of the virus by coughing. Also, many patients would have to be put back on therapy with systemic glucocorticosteroids if the biologic treatment were discontinued, which could have an undesirable effect on the immune defense against COVID-19. In the case of our patient, systemic glucocorticosteroids were administered just until before the start of therapy with dupilumab. Given the wash-out time of 22 hours, our patient was no longer under the direct anti-inflammatory influence of prednisolone. However, glucocorticoids can influence immunity, for instance, by inducing the apoptosis of proinflammatory monocytes.8Achuthan A. Aslam A.S.M. Nguyen Q. Lam P.-Y. Fleetwood A.J. Frye A.T. et al.Glucocorticoids promote apoptosis of proinflammatory monocytes by inhibiting ERK activity.Cell Death Dis. 2018; 9: 267Crossref PubMed Scopus (48) Google Scholar It might be possible that this type of monocytes could contribute to a more severe course of COVID-19. However, present knowledge about the efficacy of glucocorticoids used to treat COVID-19 remains ambivalent.9Russell B. Moss C. George G. Santaolalla A. Cope A. Papa S. et al.Associations between immune-suppressive and stimulating drugs and novel COVID-19—a systematic review of current evidence.Ecancermedicalscience. 2020; 14: 1022Crossref PubMed Scopus (340) Google Scholar According to the World Health Organization, patients with chronic lung diseases (such as asthma) seem to be more at risk for a severe course of COVID-19. Interestingly, a recent report from Wuhan indicated that none of the patients included in a sample of 140 patients affected by COVID-19 had asthma or allergic rhinitisE1Zhang JJ, Dong X, Cao YY, Yuan YD, Yang YB, Yan YQ, et al. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China [published online ahead of print February 19, 2020]. Allergy. https://doi.org/10.1111/all.14238.Google Scholar; therefore, the severity level of COVID-19 could not be assessed in this particular group. Particularly interesting is the course of the olfactory disorder. Before the treatment with dupilumab, the patient had respiratory anosmia caused by the obstruction of the olfactory region by nasal polyps. A significant recovery of olfactory function occurred already after the second dose of dupilumab. Anosmia was the first sign of COVID-19 in the absence of other typical symptoms. After the patient's recovery, she regained the function of the olfactory system. Interestingly, anosmia is described as occurring in up to two-thirds of patients with COVID-19 in the affected countries.E2Neurology BoDotSSoCovid-19: recommendations of the Spanish Society of Neurology (SEN) in relation to the loss of smell as a possible early symptom of CoVID-19 infection.http://www.sen.es/noticias-y-actividades/222-noticias/covid-19-informacion-para-pacientes/2663-covid-recomendaciones-de-la-sociedad-espanola-de-neurologia-sen-en-relacion-con-la-perdida-de-olfato-como-posible-sintoma-precoz-de-infeccion-por-covid-19Date: 2020Google Scholar, E3Luers J.C. Klussmann J.P. Guntinas-Lichius O. The Covid-19 pandemic and otolaryngology: what it comes down to? [Article in German; Abstract available in German from the publisher].Laryngorhinootologie. 2020; 99: 287-291PubMed Google Scholar The patients report a sudden onset of almost complete loss of the olfactory function. However, so far, this has only been determined while collecting patients' medical history and not through validated smell tests. The pathomechanism of the olfactory dysfunction during COVID-19 is not yet known. Nevertheless, a newly occurring olfactory disorder should be assessed as an essential symptom of COVID-19, and the patients affected by anosmia should be regarded as infectious until tested for COVID-19. In summary, we delivered the first piece of evidence supporting the view that patients with severe CRSwNP can continue to be treated with dupilumab during COVID-19. Emerging information about the course of SARS-CoV-2/COVID-19 in patients with CRSwNP should further facilitate the decision-making process about the continuation of therapy with dupilumab. Table E1A white blood cell count and differentialParameterBefore the infectionSeptember 30, 2019After COVID-19 diagnosisApril 7, 2020COVID-19–freeApril 22, 2020HgB (g/dL)14.207.9013.30HCT (%)413638Erythrocytes4.704.064.30WBC (×109/L)10.406.807.20Thrombocytes (absolute)411.00404.00301.00Neutrophils (absolute) (×109/L)6.643.63.46Lymphocytes (absolute) (×109/L)2.82.522.73Monocytes (absolute) (×109/L)0.620.470.48Eosinophils (absolute) (×109/L)0.170.220.24Basophils (absolute) (×109/L)0.060.100.06Neutrophils (%)63.852.649.3Lymphocytes (%)26.937.138.8Monocytes (%)6.06.96.8Eosinophils (%)2.12.53.4Basophils (%)0.60.90.9HCT, Hemotacrit; WBC, white blood cell. Open table in a new tab HCT, Hemotacrit; WBC, white blood cell.