tbuckley/cabot-search huggingface dataset:
Effect analysis of the technique of retrograde puncture of popliteal artery applied in the interventional therapy of lower extremity arteriosclerosis obliterans patients
Authors: Xuemin Zhang, Jingjun Jiang, Xiaoming Zhang, Wei Li, Qingle Li, Yang Jiao, Zhibin He, Changshun He
Journal: BMJ (2016)

To investigate the effectiveness of retrograde puncture of popliteal artery in lower extremity arteriosclerosis obliterans(ASO) patients classified as TASC(Tans-Atlantic Inter-Society Consensus)C/D. Retrospective analysis of 35 lower extremity ASO patients, 28 male and 7 female , the mean age was 72±8, 23 cases of Rutherford 3, 8 cases of Rutherford 4 and 4 cases of Rutherford 5. Preoperative ABI was 0.35±0.14, Lesion length in CT angiography (CTA) was (18±5) cm. The technique success rate of 35 cases was 100%. The puncture time was (6±4) min.6 cases used 4 F sheath and 29 cases used no sheath technology at the puncture site. In 27 cases guide wires passed retrograde through the occluded superficial femoral artery lesion and returned to the true lumen.8 cases of SAFARI technology to established the guild wire track. The complication rate of retrograde puncture was 14.2%(5/35), 2 cases of postoperative hematoma appeared at the puncture site the next day, 2 cases of pseudoaneurysms emerged and 1 case of postoperative arteriovenous fistula at the puncture site of popliteal area were found by Doppler ultrasonography before discharged. All 5 patients were recovered by conservative treatment. The retrograde puncture of popliteal artery is a safe and reliable method.


Key words: 
Arteriosclerosis; Popliteal artery; Punctures
老年卒中相关性肺炎临床特点分析
Authors: 徐娟娟, 楼丽娜
Journal: BMJ (2012)

回顾性分析2007年至2010年的120例老年卒中后吸人性肺炎病例资料.检出的132株病原菌中,革兰阴性杆菌为主(85株),耐药率高,临床表现差异大.需根据病原学特点合理使用抗生素,积极防治老年卒中患者吸人性肺炎的发生。
Evaluation of four approaches in screening of cervical lesions
Authors: Min Jiang, Min Yu, Xin-mei Hu
Journal: BMJ (2012)

Exfoliative cell samples were collected from 545 patients in outpatient clinic of Kelamayi Centre Hospital from Sep 2009 to Dec 2010. Liquid-based cytology test ( LCT ) and high-risk human papillomavirus (HR-HPV) test were performed in exfoliative cells; and colposcopic biopsy was undertaken in all patients.With the pathological results as gold standard the diagnostic values of HR-HPV test,LCT test,HPV-LCT serial test and HPV-LCT parallel test were evaluated for cervical cancer screening.The sensitivity of HPV-LCT parallel test was 99.17％ with a Youden's index of 0.81.Our results indicate that HPV-LCT parallel test can improve significantly the detection rate of cervical cancer screening.

Key words: 
Cervical neoplasm;  Screening
Estimating productivity losses for cancer patients and caregivers of cancer patients.
Authors: Kevin Chiu, Joanna P. MacEwan, Katalin Bognar, Desi Peneva, Suepattra Grace May, Lauren Zhao, Candice Yong, Suvina Amin, Bjorn Bolinder, Katharine Batt, James Baumgardner
Journal: Journal of Clinical Oncology (2020)

e19381 Background: Although cancer is a leading cause of illness in the United States, its true impact on productivity is poorly understood. Traditional approaches to capturing health-related productivity loss—e.g., the human capital method—focus on patients’ foregone wages, overlooking fringe benefits and the impacts incurred by caregivers and co-workers. Thus, the value of lost productivity is often underestimated. We sought to comprehensively estimate productivity loss incurred by working-age cancer patients and unpaid caregivers in the United States. Methods: We conducted a cross-sectional survey study of (i) non-small cell lung cancer (NSCLC) and breast cancer (BC) patients, and (ii) unpaid caregivers. To measure loss associated with absenteeism and presenteeism, participants reported pre- and post-cancer diagnosis income, hours worked, and time to complete tasks. The “multiplier effect” method was used to measure productivity loss incurred by co-workers due to patient or caregiver absenteeism and/or presenteeism. Exploratory multivariable analyses controlled for cancer type, stage, age, time since diagnosis, oncogene mutation status, and industry sector. Results: A total of 404 participants (104 BC, 100 NSCLC patients; 100 BC, 100 NSCLC caregivers) completed the surveys. Of these, 319 participants (162 BC, 157 NSCLC) who worked ≥40 weeks in the year pre-diagnosis and who did not transition from part- to full-time work after diagnosis were included in the analysis. Over a third of the NSCLC (33%) and BC (43%) patients left the workforce after diagnosis. For patients, estimated mean annual productivity loss equaled $123,792 (144% of mean income pre-diagnosis) for NSCLC and $123,502 (209% of mean income pre-diagnosis) for BC. For caregivers, the estimated mean annual productivity loss was $90,421 (108% of mean income pre-diagnosis) for NSCLC and $143,839 (190% of mean income pre-diagnosis) for BC. Exploratory analyses also found that patient age and stage at diagnosis were positively correlated with a greater absenteeism effect. Conclusions: This study found that traditional approaches, such as the human capital method, significantly underestimate productivity loss in cancer patients and caregivers. Holistic approaches that include lost wages, fringe benefits, and teamwork effects, are better approaches to understanding the amplified impact cancer can have for patients, caregivers, and co-workers.
Community based integrated intervention for prevention and management of chronic obstructive pulmonary disease (COPD) in Guangdong, China: cluster randomised controlled trial
Authors: 周玉民, 胡国平, 王大礼, 王少毅, 王宇骏, 刘志刚, 胡锦兴, 石喆, 彭公永, 刘升明, 吕嘉春, 郑劲平, 王健, 钟南山, 冉丕鑫
Journal: BMJ (2011)

Objective
To evaluate the effects of a community based integrated intervention for early prevention and management of chronic obstructive pulmonary disease (COPD) in China.


Design
Cluster randomised controlled trial.


Setting
Eight healthcare units in two communities.


Participants
Of 1062 people aged 40-89, 872 (101 with COPD and 771 without COPD) who fulfilled the inclusion and exclusion criteria were allocated to the intervention or the usual care programmes.


Intervention
Participants randomly assigned to integrated intervention (systematic health education, intensive and individualised intervention, treatment, and rehabilitation) or usual care.


Main outcome measures
Annual rate of decline in forced expiratory rate in one second (FEV1) before use of bronchodilator.


Results
Annual rate of decline in FEV1 was significantly lower in the intervention community than the control community, with an adjusted difference of 19 ml/year (95% confidence interval 3 to 36) and 0.9% (0.1% to 1.8%) of predicted values (all P<0.05), as well as a lower annual rate of decline in FEV1/FVC (forced vital capacity) ratio (adjusted difference 0.6% (0.1% to 1.2%), P=0.029). There were also higher rates of smoking cessation (21% v 8%, P<0.004) and lower cumulative death rates from all causes (1% v 3%, P<0.009) in the intervention community than in the control community during the four year follow-up. Improvements in knowledge of COPD and smoking hazards, outdoor air quality, environmental tobacco smoke, and working conditions were also achieved (all P<0.05). The difference in cumulative incidence rate of COPD (both around 4%) and cumulative death rate from COPD (2% v 11%) did not reach significance between the two communities.


Conclusions
A community based integrated intervention can have a significant impact on the prevention and management of COPD, mainly reflected in the annual rate of decline in FEV1.
全科医生应掌握新生儿眼病普查的技能
Authors: 周仲华
Journal: BMJ (2007)

3年前,我还在沈阳,经常和几个学习全科的医生跟着美国家庭医生Peter去沈阳福利院义诊.有一次,我们给一个刚刚被送到福利院的孩子体检,她大约2岁(没人知道她确切的年龄和既往的任何情况)。
视触叩听急腹症:急性胆系疾病
Authors: 吴东, 韩显林, 朱峰
Journal: BMJ (2012)

胆系来源的急腹症包括胆绞痛、急性胆囊炎和急性胆管炎.这类疾病在我国发病率正逐渐上升.熟悉胆系病变的解剖和病理机制,有助于我们深入理解其临床表现,从而正确诊断.急性胆管炎是临床急症,延误治疗后果严重,更需要早期识别并加以处理。
Long non-coding RNAs towards precision medicine in gastric cancer: early diagnosis, treatment, and drug resistance
Authors: Li Yuan, Zhi-Yuan Xu, Shan-Ming Ruan, Shaowei Mo, Jiang-Jiang Qin, Xiang-Dong Cheng
Journal: Molecular Cancer (2020)

Gastric cancer is a deadly disease and remains the third leading cause of cancer-related death worldwide. The 5-year overall survival rate of patients with early-stage localized gastric cancer is more than 60%, whereas that of patients with distant metastasis is less than 5%. Surgical resection is the best option for early-stage gastric cancer, while chemotherapy is mainly used in the middle and advanced stages of this disease, despite the frequently reported treatment failure due to chemotherapy resistance. Therefore, there is an unmet medical need for identifying new biomarkers for the early diagnosis and proper management of patients, to achieve the best response to treatment. Long non-coding RNAs (lncRNAs) in body fluids have attracted widespread attention as biomarkers for early screening, diagnosis, treatment, prognosis, and responses to drugs due to the high specificity and sensitivity. In the present review, we focus on the clinical potential of lncRNAs as biomarkers in liquid biopsies in the diagnosis and prognosis of gastric cancer. We also comprehensively discuss the roles of lncRNAs and their molecular mechanisms in gastric cancer chemoresistance as well as their potential as therapeutic targets for gastric cancer precision medicine.
Surgical treatment of secondary hyperparathyroidism in patients with chronic kidney disease
Authors: Shuai Xue, Li Zhang, Jia Liu, Peisong Wang, Guang Chen
Journal: BMJ (2016)

Secondary hyperparathyroidism is the most common complication of patients with chronic kidney disease. For patients poorly responding to medical treatment, parathyroidectomy would be the best choice. This article reviews the indications and modalities of surgical treatment for secondary hyperparathyroidism in patients with chronic kidney disease.


Key words: 
Hyperparathyroidism, secondary; Surgical procedures, operative
MSB2311, an anti-programmed death-ligand 1 antibody, in advanced solid tumors and hematological malignancies: Safety and tolerability, early anti-cancer activities from a phase I study in Chinese patients.
Authors: Xichun Hu, Jifang Gong, Dongmei Ji, Lin Shen, Yufeng Li, Mengde Wang, Yingjie Huang, Zhenzhong Xia, Lingmin Lu, John Huang, Li Xu, Jenny Li, Yuntao Wan, Xueming Qian
Journal: Journal of Clinical Oncology (2020)

e15011 Background: MSB2311 is a novel humanized programmed death-ligand 1 (PD-L1) antibody with a unique pH-dependent antigen binding property that enables intra-tumor recycling and potentiates tumor penetration. Methods: Patients with metastatic solid tumors and selected hematological malignancies progressed after standard treatments were enrolled in this Phase I study. In dose escalation part, MSB2311 was given at levels of 3, 10, and 20 mg/kg intravenously every 3 weeks. At the dose expansion part, patients with enriched biomarker expression, either EBV positive, PD-L1 positive, MSI-High or TMB-High, were enrolled and dosed either in 20mg/kg Q3W or 10mg/kg Q2W. Primary objectives are to evaluate the safety and tolerability and to identify MTD/MAD and RP2D. Secondary objectives include the assessment of pharmacokinetics, immunogenicity, and preliminary efficacy per RECIST1.1. Results: At data cut-off at Jan 19, 2020, 27 Chinese patients have been treated, 18 (66.7%) of them received at least 4 cycles of MSB2311. No dose limiting toxicity was reported and MTD has not been identified. The most common treatment-emergent adverse events (TEAEs) ( &gt; 10%) included: anemia, hypothyroidism, hyperglycemia, hypertriglyceridemia, nausea, vomiting, fatigue, malaise, pyrexia and cough. Eleven patients (40.7%) experienced Grade 3 TEAEs, and 6 patients (22.2%) experienced SAEs. One lymphoma patient experienced grade 4 hypercalcemia and platelet count decreased, which were assessed as related to study drug by the investigator. MSB2311 displayed a linear pharmacokinetic profile with calculated T 1/2 of about 10-13 days. Among 18 evaluable patients treated with 20 mg/kg Q3W, the best response of PR was observed in 4 out of 12 patients with solid tumors including NSCLC, NPC and Gastric cancer, and 1 out of 6 patients with lymphoma. The mean duration of response was 127 (range 38-278) days. Conclusions: MSB2311 demonstrated a manageable safety profile and promising preliminary antitumor activity in patients with advanced solid tumors and hematological malignancies.
Cases studies: falls in the elderly
Authors: Venus W Lam
Journal: BMJ (2016)

老年人跌倒的发生率高，且很多首诊于社区诊所或卫生服务中心。展示2例老年人跌倒在社区诊所工作中的实践案例，通过检查－提问－回答的方式帮助全科医生了解老年人跌倒的危险因素、风险评估和干预措施。
Diagnostic performance of skeletal survey versus 18F-FDG-PET/CT for detecting lytic lesions in smoldering multiple myeloma.
Authors: Elizabeth M. Hill, Alexander Dew, Candis Morrison, Peter L. Choyke, Esther Mena, Liza Lindenberg, Dickran Garo Kazandjian
Journal: Journal of Clinical Oncology (2020)

8532 Background: Per NCCN Guidelines for smoldering multiple myeloma (SMM), whole body radiography, i.e. skeletal survey (SS), should be used to rule out osteolytic bone lesions. If negative, more sensitive imaging techniques such as whole body 18 F-FDG-PET/CT(PET/CT), MRI, or low dose CT should be used to differentiate between SMM and multiple myeloma (MM). The false-negative rate of SS is high (30-70%). The frequency of false-positive SS in SMM is less well known but important because of its common use in community practice. We examine the specificity of SS in patients with a presumed diagnosis of SMM and question if SS is still warranted prior to modern imaging techniques to confirm a diagnosis of SMM. Methods: Records of patients sequentially referred from the community and evaluated for a presumed diagnosis of SMM at the National Institutes of Health Myeloma Program between April 2010 to January 2020 were reviewed. Patients with a SS and PET/CT performed within 30 days were included. Positive findings on PET/CT were defined per the 2014 IMWG criteria as one or more sites of osteolytic bone destruction seen on CT. The sensitivity and specificity of SS were calculated using PET/CT as the reference test. Results: Charts from 144 patients with presumed SMM were reviewed. A total of 76 SMM patients had both a SS and PET/CT performed within 30 days of each other. Sixty-four patients (84.2%) showed concordant results. Twelve (15.8%) patients had discordant imaging results. SS was falsely negative in 3 (4.7% (95% CI: 1.2%-14.2%)) patients and falsely positive in 9 (69.2% (95% CI: 38.9%-89.6%)) patients. SS had a sensitivity of 57.1% (95% CI: 20.2%-88.2%) and a specificity of 86.9% (95% CI: 76.2-93.5). Conclusions: In patients presumed to have SMM, disease burden is low thus highly sensitive imaging modalities are needed to rule out bone disease. This study confirms the low sensitivity of SS in the SMM population. It more importantly points out the low specificity of SS in SMM. The IMWG no longer recommends conventional SS prior to whole body CT (or PET/CT) as first imaging choice in SMM. While the argument may be made that SS should still be used upfront due to low cost and widespread availability, this study shows the risk of overestimating disease. Over 10% of patients in this series had false positive disease on SS and thus at risk of receiving unnecessary treatment. Not only concerning for patient toxicity but more so financial toxicity. If SS is used, it is important to review positive findings directly with a radiologist and consider follow-up confirmatory imaging.
Specifying the treatment targets of exercise interventions: do we?
Authors: Lianne Wood, Rachel Ogilvie, Jill A Hayden
Journal: British Journal of Sports Medicine (2020)

Persistent non-specific low back pain (NSLBP) is the leading cause of disability worldwide.1 Although exercise is the most recommended intervention for NSLBP,2 the effects are small to moderate.3 Researchers who conduct and publish exercise-focused randomised controlled trials (RCTs) (clinicians/scientists) are doing a ‘poor to moderate’ job reporting.4 Gaps in reporting limit evidence synthesis and the ability of clinicians to replicate the exercises in a clinical setting.

The CONSORT statement and the Template for Intervention Description and Replication checklist aim to improve minimum reporting standards. More recently, the Consensus on Exercise Reporting Template (CERT) was developed to work alongside the existing RCT checklists. Authors and journal editors need to embrace these standards to ensure a high quality of research conduct and implementation. If you work in exercise medicine/science and do not yet know ‘CERT’, we encourage you to study it and use it.

Despite CERT adding value for our community, it fails to address the aim or target of the exercise intervention.5 Related to the content of this discussion—low back pain—our call to action is that researchers should be clear on the purpose of exercise treatment. For example, is the purpose of exercise therapy to reduce pain, to make the patient stronger or to improve function? Understanding the aim of the exercise therapy will impact the selection of the exercise intervention and RCT design.5 Clearly, specified target(s) of exercise are helpful—yoga, may aim to increase strength and flexibility as well …
残胃病变155例的胃镜及临床表现
Authors: 陈建荣, 郭锡明
Journal: BMJ (2006)

回顾分析我院155例胃部分切除术后患者的胃镜资料及临床表现.结果显示在残胃病变中以残胃及吻合口炎最常见,占76.1%(118例),多发生于BillrothⅡ式术后;残胃及吻合口溃疡16.1%(25例),多发生于Billroth Ⅰ式术后;残胃癌7.7%(12例);缝线残留5.2%(8例),息肉4.5%(7例).残胃病变的临床表现主要为上腹疼痛、恶心、呕吐、纳差、消瘦、呕血、黑便等,缺乏特异性.提示为减少残胃病变,尤其是残胃癌的发生,要严格掌握胃切除的指征并选择合理的手术方式,且手术后应定期内镜检查。
脊髓亚急性联合变性临床分析20例
Authors: 吴瑞云, 龚涛
Journal: BMJ (2006)

脊髓亚急性联合变性(subacute combined degeneration of the spinal cord,SCD)是由于维生素B12缺乏引起的神经系统变性疾病,通常与恶性贫血伴发.病变主要累及脊髓侧索、后索及周围神经,严重时大脑白质及视神经也可受累.病理改变可以是变性、坏死,也可以是脱髓鞘,早期髓鞘肿胀,病情发展髓鞘断裂,最终轴突变性.临床表现为双下肢深感觉缺失、感觉性共济失调、痉挛性截瘫及周围神经病变等.我们对北京医院2000年至2003年确诊的SCD 20例进行回顾性分析,报告如下。
Prostate cancer associated natural killer cells show a pro-angiogenic and pro-inflammatory phenotype.
Authors: Adriana Albini, Antonino Bruno, Matteo Gallazzi, Angelo Naselli, Lorenzo Mortara, Douglas M Noonan
Journal: Journal of Clinical Oncology (2020)

e17544 Background: Prostate cancer (PCa) represents the second most common cancer worldwide in men. Angiogenesis has been shown to play a crucial role in PCa progression in several preclinical models. Production of pro-angiogenic factors can correlate with metastasis, Gleason score and prognosis in PCa and plasma levels of VEGF were shown to be higher in patients with metastatic PCa than those with localized disease. Natural killer (NK) cells, effector lymphocytes of the innate immunity, have been found to be immunosuppressed in solid cancers, including PCa. Methods: Here, we phenotypically and functionally characterize circulating NK cells from PCa patients and their interaction with endothelial cells and macrophages. NK cell subset distribution has been investigated by multicolor flow cytometry (FACS) for surface antigens on peripheral blood samples PCa patients (TANKs). Conditioned media (CM) from FACS-sorted TANKs were used for functional studies of angiogenesis, on human umbilical-vein endothelial cells (HUVEC), studies for macrophage recruitment (migration assay on Boyden chambers) and polarization. Molecular studies were performed by real time PCR (qPCR) on HUCECs and macrophages exposed to CM of TANKs. Protein arrays were performed to characterize the secretome on FACS-sorted TANKs. Results: We found that TANKs acquire a pro-angiogenic/ dNK-like CD56 bright CD9 + CD49a + CXCR4 + phenotype. The same phenotype was observed on cytolytic NK cells, from healthy donors, exposed to CMs of three different PCa cell lines (PC-3, DU-145, LNCaP), together with increased production of CXCL8, Angiogenin, Angiopoietin1 and reduced production of TNFa, IFNg and GranzymeA. CMs from TANKs support the formation on capillary-like structures on HUVEC, together with increased expression of VEGF, VEGR-2, CXCL8, ICAM-1 and VCAM-1. Secretome analysis revealed the ability of TANKs release pro-angiogenic pro-invasive factors (CLXL8, MMP-1, MMP-9; uPAR) and cytokines/chemokines involved in macrophage recruitment (CCL1, CCL2, CCL5, CCL7, CCL13, CXCL1, CXCL11) and M2-like polarization (IL-10). Finally, CMs from TANKs can recruit THP-1 monocyte and polarize THP-1 macrophage towards CD206, Arginase1, CXCL8-expressing M2-like/TAM phenotype. Conclusions: Our results place PCa TANKs as effector cells able in supporting angiogenesis in PCa by directly interaction with endothelial cells and via macrophage polarization.
Quantitative assessments of real-time elastosonography in the diagnosis of uterine fibroids and adenomyoma
Authors: Qinghong Zhao, Hua Shi, Jing Yang, Jiaqi Hu, Yuguo Zhang
Journal: BMJ (2015)

To explore the diagnostic values of real-time elastosonography quantitative parameters in uterine fibroids and adenomyoma. The clinical data of 175 cases were analyzed retrospectively. Strain ratios (B/A) of lesion and normal adjacent myometrium were measured and mean B/A was calculated. The average B/A of uterine fibroids and adenomyoma was 3.81±0.52 and 1.39±0.46 respectively. And there was significant statistic difference (t=2.563, P<0.05). the accuracy rates of real-time elastosonography in the diagnosis of uterine fibroids and adenomyoma were high at 97.4%(148/152) and 95.3%(122/128) respectively. Real-time elastosonography has high diagnostic values for uterine fibroids and adenomyoma.


Key words: 
Elasticity imaging techniques; Leiomyoma; Uterus
Randomized phase II trial of modified (m) FOLFOX6 induction chemotherapy with or without aflibercept before standard chemoradiotherapy (CRT) and total mesorectal excision (TME) in patients with high-risk rectal adenocarcinoma (HRRC): Final results of the GEMCAD 1402, and by molecular subtypes.
Authors: Carlos Fernandez-Martos, Isidro Machado, Carles Pericay, Nuria Salas, Jaime Feliu Batlle, Sanne ten Hoorn, Louis Vermeulen, Ferran Losa, Rocio Garcia Carbonero, Vicente Alonso, Ruth Vera, Javier Gallego, Jaume Capdevila, Antonieta Salud, Miguel Nogué, Joan Maurel, Laura Layos, Clara Montagut, Xabier Garcia-Albeniz
Journal: Journal of Clinical Oncology (2020)

4102 Background: Neoadjuvant chemotherapy (CT) followed by CRT and TME is a treatment option for clinically staged HRRC. The goal of the GEMCAD 1402 trial was to evaluate the benefit of adding an antiangiogenic drug to the neoadjuvant CT. The analysis of primary endpoint showed a better response rate in the experimental arm (Fernandez-Martos et al. Jama Oncol 2019). Here we present 3-year disease-free survival (DFS) and a retrospective analysis of consensus molecular subtypes by Immunohistochemistry (CMSs-IHQ). Methods: Patients (p) with middle or distal third, mrT3/T4/N2 rectal adenocarcinoma were randomly assigned (2:1), to mFOLFOX6 with (arm 1, n=115) or without Aflibercept (arm 2, n=65) prior to CRT (capecitabine with 50.4 Gy in 28 fractions) and TME. Tissue microarrays from 90 (58 arm1, 32 arm 2) p were stained for nine markers (CDX2, FRMD6, HTR2B, ZEB1, KER, MSH2, MSH6, PMS2 and MLH1) by IHQ using both semiquantitative and quantitative approaches. Cases were classified as CMS1-IHQ1, CMS-IHQ2/3 or CMS-IHQ 4 (immune, epithelial or mesenchymal subtypes). Results: In the intention-to-treat population after a median follow-up time of 38 months, 29 p (25%) in arm 1 had a DFS-related event, as compared with 14 p (21%) in arm 2 (HR 1.2063, 95% confidence interval 0.6374 to 2.2829, P=0.5644. The rate of DFS at three years was 75.2% (95% confidence interval, 66.1% to 82.2%) in arm 1 and 81.5% (95% confidence interval, 69.8% to 89.1%) in arm 2 (P=0.5638 by the exact stratified log-rank test). Overall 0/80/10 p were classified as CMS-IHQ1, CMS-IHQ2/3 or CMS-IHQ4 respectively. The pathological complete response (pCR) rate (ypT0N0) was achieved in 27.5% and 0% in epithelial and mesenchymal subtypes respectively. A trend towards worse survival for the mesenchymal subtype was observed. Conclusions: Adding aflibercept to induction mFOLFOX6 is not associated with an improvement in DFS. Our findings suggest that CMSs-IHQ subtypes could be predictive for pCR with this treatment strategy. Clinical trial information: NCT02340949 .