tbuckley/cabot-search huggingface dataset:
Abandon of intramuscular administration of rabies immunoglobulin for post-exposure prophylaxis in the revised guidelines in the Netherlands in 2018: cost and volume savings
Authors: Imke Schreuder, Cornelis De Pijper, Rob van Kessel, Leo Visser, Hans van den Kerkhof
Journal: Eurosurveillance (2020)

The World Health Organization (WHO) issued an updated position paper on rabies in 2018, mainly focusing on simplification of vaccination schedules and use of rabies immunoglobulin (RIG). The maximum amount of RIG anatomically feasible should be infiltrated exclusively in and around the wound and will no longer be calculated solely based on body weight. We describe the practical guideline implementing the revised RIG policy in the Netherlands on how to determine the amount of RIG for local administration. We calculated savings achieved through the revised WHO policy. We used information from a national database including rabies consultations in the Netherlands and clinical information from a public health service, clinical practitioners and national data on the amount of distributed RIG. Between 2008 and 2019, 5,164 consultations were registered. The most frequently affected anatomical location was hand or leg (43%). Around 80% concerned minor injuries (< 2 cm). From January 2016 to end December 2019, 7,361 mL RIG were distributed for 1,042 possible rabies exposures (EUR 1.4 million). Since implementing the revised policy, the amount of RIG distributed per order has sharply decreased (59%). Infiltrating RIG only locally saved large quantities of human RIG (EUR 1.1 million during 4 years) in the Netherlands.
346P Phase I study of the liposomal formulation of eribulin (E7389-LF): Results from the HER2-negative breast cancer expansion
Authors: K. Tamura, S. Takahashi, T. Mukohara, M. Tanioka, H. Yasojima, M. Ono, Y. Naito, T. Shimoi, Y. Otani, K. Kobayashi, T. Kogawa, T. Suzuki, T. Takase, R. Matsunaga, N. Masuda
Journal: Annals of Oncology (2020)
961P Genomic and transcriptomic profiling in head and neck tumours to identify treatment options: The WINTHER trial experience
Authors: I. Brana, Y. Loriot, R. Berger, E. Rubin, J. Rodon, W.H. Miller, A.M. Tsimberidou, P. Saintigny, R. Dienstmann, P. Nuciforo, C. Bescos, J. Lorente, C. Viaplana, F. Wunder, C. Bresson, J. Tabernero, R.L. Schilsky, V. Lazar, R. Kurzrock, J-C. Soria
Journal: Annals of Oncology (2020)
Kidney Single-Cell Atlas Reveals Myeloid Heterogeneity in Progression and Regression of Kidney Disease
Authors: Bryan R. Conway, Eoin D. O’Sullivan, Carolynn Cairns, James O’Sullivan, Daniel J. Simpson, Angela Salzano, Katie Connor, Peng Ding, Duncan Humphries, Kevin Stewart, Oliver Teenan, Riinu Pius, Neil C. Henderson, Cécile Bénézech, Prakash Ramachandran, David Ferenbach, Jeremy Hughes, Tamir Chandra, Laura Denby
Journal: Journal of the American Society of Nephrology (2020)

Significance Statement The innate immune system is central to injury and repair in the kidney, but the heterogeneity of myeloid cell subsets behind these processes is unknown. Complementary technologies—including bulk tissue transcriptomics, integrated droplet– and plate-based single-cell RNA sequencing, and paired blood exchange—resolved myeloid cell heterogeneity in a murine model of reversible unilateral ureteric obstruction, creating a single-cell atlas. The identified novel myeloid subsets could be targeted to ameliorate injury or enhance repair, including an Arg1+ monocyte subset present during injury and Mmp12+ macrophages present during repair. Standard flow cytometry to detect cell surface markers would have missed these subsets. Complementary techniques capture the complexity and dynamics of monocyte, dendritic cell, and macrophage phenotypes in the injured and repairing kidney. Background Little is known about the roles of myeloid cell subsets in kidney injury and in the limited ability of the organ to repair itself. Characterizing these cells based only on surface markers using flow cytometry might not provide a full phenotypic picture. Defining these cells at the single-cell, transcriptomic level could reveal myeloid heterogeneity in the progression and regression of kidney disease. Methods Integrated droplet– and plate-based single-cell RNA sequencing were used in the murine, reversible, unilateral ureteric obstruction model to dissect the transcriptomic landscape at the single-cell level during renal injury and the resolution of fibrosis. Paired blood exchange tracked the fate of monocytes recruited to the injured kidney. Results A single-cell atlas of the kidney generated using transcriptomics revealed marked changes in the proportion and gene expression of renal cell types during injury and repair. Conventional flow cytometry markers would not have identified the 12 myeloid cell subsets. Monocytes recruited to the kidney early after injury rapidly adopt a proinflammatory, profibrotic phenotype that expresses Arg1 , before transitioning to become Ccr2 + macrophages that accumulate in late injury. Conversely, a novel Mmp12 + macrophage subset acts during repair. Conclusions Complementary technologies identified novel myeloid subtypes, based on transcriptomics in single cells, that represent therapeutic targets to inhibit progression or promote regression of kidney disease.
Repurposing a novel anti-cancer RXR agonist to attenuate murine acute GVHD and maintain graft-versus-leukemia responses
Authors: Govindarajan Thangavelu, Chao Wang, Michael Loschi, Asim Saha, Mark J. Osborn, Scott N. Furlan, Kazutoshi Aoyama, Cameron McDonald-Hyman, Ethan G. Aguilar, Amanda S. Janesick, Roshantha A. Chandraratna, Yosef Refaeli, Angela Panoskaltsis-Mortari, Kelli P. MacDonald, Geoffrey R. Hill, Robert Zeiser, Ivan Maillard, Jonathan S. Serody, William J. Murphy, David H. Munn, Bruce Blumberg, Chrysothemis Brown, Vijay Kuchroo, Leslie S. Kean, Keli L. Hippen, Randolph J. Noelle, Bruce R. Blazar
Journal: Blood (2020)
LBA89 A randomized multicentered phase III study to evaluate apatinib in subjects with locally advanced or metastatic radioactive iodine-refractory differentiated thyroid cancer
Authors: Y-S. Lin, S-K. Qin, Z-Y. Li, H. Yang, W. Fu, S-H. Li, W-X. Chen, Z-R. Gao, W-B. Miao, H-Q. Xu, Q. Zhang, X-M. Zhao, J-D. Bao, L-F. Li, Y. Ren, C-H. Lin, S-H. Jing, Q-J. Ma, J. Liang, G. Chen
Journal: Annals of Oncology (2020)
32P Comparison of fully automated microsatellite instability test to immunohistochemistry for mismatch repair protein expression in endometrial carcinoma
Authors: M. Mendiola, I. Ruz-Caracuel, V. Heredia Soto, J.L. Ramón Patiño, L.E. García de la Calle, Á. López Janeiro, F.J. Escudero, P. Ruiz, M. Miguel, R. Crespo, L. Yebenes, A. Berjón, A. Gallego Martínez, A. Peláez-García, D. Hardisson, A. Redondo
Journal: Annals of Oncology (2020)
347P Results of the phase Ib dose escalation study of MEN1611, a PI3K inhibitor, combined with trastuzumab (T) ± fulvestrant (F) for HER2+/PIK3CA mutant (mut) advanced or metastatic (a/m) breast cancer (BC)
Authors: M. Piccart, M. Ruiz Borrego, F. Duhoux, H-T. Arkenau, B. Doger de Spéville, H. Wildiers, M. Campone, D. Tosi, J. Garcia-Corbacho, B. Jimenez, S. Escrivá-de Romaní, A.M. Wardley, P. Tassone, V. Boni, Y. Jerez, P.G. Aftimos, A. Hennequin, F. Amair-Pinedo, A.U.E. Pellacani, D.O. Laurent
Journal: Annals of Oncology (2020)
402MO Final results of the CARACAS study: Randomized phase II trial of avelumab alone or with cetuximab for unresectable, locally advanced or metastatic squamous cell anal carcinoma progressed to at least one line of treatment
Authors: S. Lonardi, F. Pietrantonio, A.A. Prete, M. Messina, V. Formica, D.C. Corsi, E. Cortesi, L.G. Frassineti, M.G. Zampino, M. Ronzoni, M. Scartozzi, M. Casagrande, V. Conca, F. Bergamo, M. Prisciandaro, R. Intini, M. Antista, D.B. Paola, V. Vettore, V. Zagonel
Journal: Annals of Oncology (2020)
702O Cabozantinib (C) in combination with atezolizumab (A) as first-line therapy for advanced clear cell renal cell carcinoma (ccRCC): Results from the COSMIC-021 study
Authors: S. Pal, C-K. Tsao, C. Suarez, W. Kelly, L. Pagliaro, U.N. Vaishampayan, Y. Loriot, S. Srinivas, B.A. McGregor, A. Panneerselvam, D. Curran, T.K. Choueiri, N. Agarwal
Journal: Annals of Oncology (2020)
The direct effect of pneumococcal conjugate vaccines on invasive pneumococcal disease in children in the Latin American and Caribbean region (SIREVA 2006–17): a multicentre, retrospective observational study
Authors: Clara Inés Agudelo, Carlos Castañeda-Orjuela, Maria Cristina de Cunto Brandileone, Gabriela Echániz-Aviles, Samanta Cristine Grassi Almeida, María Noemí Carnalla-Barajas, Mabel Regueira, Sofia Fossati, Pedro Alarcón, Pamela Araya, Carolina Duarte, Jacqueline Sánchez, Mirna Novas, Gilda Toraño-Peraza, Misladys Rodríguez-Ortega, Gustavo Chamorro-Cortesi, Anibal Kawabata, Gabriela García-Gabarrot, Teresa Camou, Enza Spadola, Daisy Payares, Ana Lucía Andrade, José Luis Di Fabio, Elizabeth Castañeda, A Corso, Paula Gaguetti, Omar Veliz, C S Pereira, D Napoli, M A Moscoloni, M L L Silva e Guerra, S Bokermann, Lincoln S do Prado, U J Días, J C Hormazabal, B Rojas, S Castro, D Ibáñez, J Fernandez, O Sanabria, J Moreno, Z Alarcón, M K Rodriguez, A Bautista, L P Solis, D S Apaza, M A Capote, J M Feris, D Cedano, Araceli Soto-Noguerón, Maria E Velázquez-Meza, Margarita Hernández-Salgado, M E León, Minako Nagai, Liliana Rojas, M L Vega, G P Giffoni, V Félix
Journal: The Lancet Infectious Diseases (2020)
Re: Predictors of mortality for patients with COVID-19 pneumonia caused by SARSCoV-2: a prospective cohort study
Authors: Hai-Jun Yang, Yan-Mei Zhang, Min Yang, Xing Huang
Journal: European Respiratory Journal (2020)

<b>There are several issues which are worth clarifying in the paper "Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study" published in the <i>European Respiratory Journal</i></b>https://bit.ly/336rv2Y
Imaging risk in pulmonary arterial hypertension
Authors: Roberto Badagliacca, Carmine Dario Vizza
Journal: European Respiratory Journal (2020)

<b>Risk assessment is essential in PAH to optimise treatment decisions aiming to slow disease progression. Imaging of the RV matters in the assessment of these patients, and needs to be seriously considered in the elaboration of more performant tools.</b>https://bit.ly/3ibbo9F
246P A survey of breast cancer patients’ attitudes toward the breast reconstruction based on breast implant associated-anaplastic large cell lymphoma (BIA-ALCL)
Authors: H. Suzuki, N. Ueda, S. Matsumura, M. Masui, C. Tsutsumi, M. Mori, Y. Okubo, K. Ishiguro
Journal: Annals of Oncology (2020)
1892P One-year experience at the Catalan Institute of Oncology (ICO) Drug Desensitisation Centre (DDC)
Authors: K. Molina-Mata, J. Martí-Garrido, P. Vazquez-Revuelta, R. Lleonart Bellfill, C. Fernández-López, R. Madrigal-Burgaleta
Journal: Annals of Oncology (2020)
973TiP LEAP-010: Phase III study of first-line pembrolizumab with or without lenvatinib in patients (pts) with recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC)
Authors: L.L. Siu, B. Burtness, E.E. Cohen, K.J. Harrington, L.F. Licitra, D. Rischin, Y. Zhu, C.E. Okpara, C. Pinheiro, R.F. Swaby, J-P. Machiels, M. Tahara
Journal: Annals of Oncology (2020)
1281P The prognostic impact of tissue tumour mutational burden (TMB) in the first-line treatment of advanced non-oncogene addicted non-small cell lung cancer (NSCLC): A systematic review and meta-analysis of randomized controlled trials
Authors: V. Gristina, A. Galvano, N. Barraco, L. Castellana, L. Insalaco, A. Guarini, M. Bono, G. Militi, M. Ricciardi, S. Cutaia, A. Cucinella, G. Madonia, L. Tomasello, C. Filorizzo, D. Fanale, L. Incorvaia, S. Rizzo, G. Badalamenti, V. Bazan, A. Russo
Journal: Annals of Oncology (2020)
The myeloid type I interferon response to myocardial infarction begins in bone marrow and is regulated by Nrf2-activated macrophages
Authors: David M. Calcagno, Richard P. Ng, Avinash Toomu, Claire Zhang, Kenneth Huang, Aaron D. Aguirre, Ralph Weissleder, Lori B. Daniels, Zhenxing Fu, Kevin R. King
Journal: Science Immunology (2020)

Sterile tissue injury is thought to locally activate innate immune responses via damage-associated molecular patterns (DAMPs). Whether innate immune pathways are remotely activated remains relatively unexplored. Here, by analyzing ~145,000 single-cell transcriptomes at steady state and after myocardial infarction (MI) in mice and humans, we show that the type I interferon (IFN) response, characterized by expression of IFN-stimulated genes (ISGs), begins far from the site of injury, in neutrophil and monocyte progenitors within the bone marrow. In the peripheral blood of patients, we observed defined subsets of ISG-expressing neutrophils and monocytes. In the bone marrow and blood of mice, ISG expression was detected in neutrophils and monocytes and their progenitors, intensified with maturation at steady-state and after MI, and was controlled by Tet2 and Irf3 transcriptional regulators. Within the infarcted heart, ISG-expressing cells were negatively regulated by Nrf2 activation in Ccr2- steady-state cardiac macrophages. Our results show that IFN signaling begins in the bone marrow, implicate multiple transcriptional regulators (Tet2, Irf3, and Nrf2) in governing ISG expression, and provide a clinical biomarker (ISG score) for studying IFN signaling in patients.
1418TiP Randomized, placebo-controlled phase III study of 1L pembrolizumab (Pembro) plus carboplatin/taxane followed by pembro with or without maintenance olaparib in patients (Pts) with metastatic squamous non-small cell lung cancer (sqNSCLC): KEYLYNK-008
Authors: J.E. Gray, T.K. Owonikoko, T. Kato, E. Nadal, A. Greystoke, A.F. Cardona, J. Penrod, Z. Wei, H. Lara-Guerra, C. Schulz
Journal: Annals of Oncology (2020)
1772P Impact assessment of SARS-CoV-2 testing on cancer patients undergoing immunosuppressive treatment
Authors: A. Tavares, D. Magalhães, A. Soares, J. Laranjinha, A. Mesquita, F. Duarte, R.C. Abreu, H. Magalhães, F. Braga, C. Sottomayor, M. Salgado
Journal: Annals of Oncology (2020)
Susceptibility to SARS-CoV-2 Infection Among Children and Adolescents Compared With Adults
Authors: Russell M. Viner, Oliver T. Mytton, Chris Bonell, G. J. Melendez-Torres, Joseph Ward, Lee Hudson, Claire Waddington, James Thomas, Simon Russell, Fiona van der Klis, Archana Koirala, Shamez Ladhani, Jasmina Panovska-Griffiths, Nicholas G. Davies, Robert Booy, Rosalind M. Eggo
Journal: JAMA Pediatrics (2020)

The degree to which children and adolescents are infected by and transmit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unclear. The role of children and adolescents in transmission of SARS-CoV-2 is dependent on susceptibility, symptoms, viral load, social contact patterns, and behavior.To systematically review the susceptibility to and transmission of SARS-CoV-2 among children and adolescents compared with adults.PubMed and medRxiv were searched from database inception to July 28, 2020, and a total of 13 926 studies were identified, with additional studies identified through hand searching of cited references and professional contacts.Studies that provided data on the prevalence of SARS-CoV-2 in children and adolescents (younger than 20 years) compared with adults (20 years and older) derived from contact tracing or population screening were included. Single-household studies were excluded.PRISMA guidelines for abstracting data were followed, which was performed independently by 2 reviewers. Quality was assessed using a critical appraisal checklist for prevalence studies. Random-effects meta-analysis was undertaken.Secondary infection rate (contact-tracing studies) or prevalence or seroprevalence (population screening studies) among children and adolescents compared with adults.A total of 32 studies comprising 41 640 children and adolescents and 268 945 adults met inclusion criteria, including 18 contact-tracing studies and 14 population screening studies. The pooled odds ratio of being an infected contact in children compared with adults was 0.56 (95% CI, 0.37-0.85), with substantial heterogeneity (I2 = 94.6%). Three school-based contact-tracing studies found minimal transmission from child or teacher index cases. Findings from population screening studies were heterogenous and were not suitable for meta-analysis. Most studies were consistent with lower seroprevalence in children compared with adults, although seroprevalence in adolescents appeared similar to adults.In this meta-analysis, there is preliminary evidence that children and adolescents have lower susceptibility to SARS-CoV-2, with an odds ratio of 0.56 for being an infected contact compared with adults. There is weak evidence that children and adolescents play a lesser role than adults in transmission of SARS-CoV-2 at a population level. This study provides no information on the infectivity of children.
Coronavirus disease 2019 in patients with inborn errors of immunity: An international study
Authors: Isabelle Meyts, Giorgia Bucciol, Isabella Quinti, Bénédicte Neven, Alain Fischer, Elena Seoane, Eduardo Lopez-Granados, Carla Gianelli, Angel Robles-Marhuenda, Pierre-Yves Jeandel, Catherine Paillard, Vijay G. Sankaran, Yesim Yilmaz Demirdag, Vassilios Lougaris, Alessandro Aiuti, Alessandro Plebani, Cinzia Milito, Virgil ASH. Dalm, Kissy Guevara-Hoyer, Silvia Sánchez-Ramón, Liliana Bezrodnik, Federica Barzaghi, Luis Ignacio Gonzalez-Granado, Grant R. Hayman, Gulbu Uzel, Leonardo Oliveira Mendonça, Carlo Agostini, Giuseppe Spadaro, Raffaele Badolato, Annarosa Soresina, François Vermeulen, Cedric Bosteels, Bart N. Lambrecht, Michael Keller, Peter J. Mustillo, Roshini S. Abraham, Sudhir Gupta, Ahmet Ozen, Elif Karakoc-Aydiner, Safa Baris, Alexandra F. Freeman, Marco Yamazaki-Nakashimada, Selma Scheffler-Mendoza, Sara Espinosa-Padilla, Andrew R. Gennery, Stephen Jolles, Yazmin Espinosa, M. Cecilia Poli, Claire Fieschi, Fabian Hauck, Charlotte Cunningham-Rundles, Nizar Mahlaoui, Klaus Warnatz, Kathleen E. Sullivan, Stuart G. Tangye
Journal: Journal of Allergy and Clinical Immunology (2020)

There is uncertainty about the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in individuals with rare inborn errors of immunity (IEI), a population at risk of developing severe coronavirus disease 2019. This is relevant not only for these patients but also for the general population, because studies of IEIs can unveil key requirements for host defense.
Lessons learnt from easing COVID-19 restrictions: an analysis of countries and regions in Asia Pacific and Europe
Authors: Emeline Han, Melisa Mei Jin Tan, Eva Turk, Devi Sridhar, Gabriel M Leung, Kenji Shibuya, Nima Asgari, Juhwan Oh, Alberto L García-Basteiro, Johanna Hanefeld, Alex R Cook, Li Yang Hsu, Yik Ying Teo, David Heymann, Helen Clark, Martin McKee, Helena Legido-Quigley
Journal: The Lancet (2020)
Accelerated FEV<sub>1</sub>decline and risk of cardiovascular disease and mortality in a primary care population of COPD patients
Authors: Hannah R. Whittaker, Chloe Bloom, Ann Morgan, Deborah Jarvis, Steven J. Kiddle, Jennifer K. Quint
Journal: European Respiratory Journal (2020)

Accelerated lung function decline has been associated with increased risk of cardiovascular disease (CVD) in a general population, but little is known about this association in chronic obstructive pulmonary disease (COPD). We investigated the association between accelerated lung function decline and CVD outcomes and mortality in a primary care COPD population. COPD patients without a history of CVD were identified in the Clinical Practice Research Datalink (CPRD)-GOLD primary care dataset (n=36 382). Accelerated decline in forced expiratory volume in 1 s (FEV 1 ) was defined using the fastest quartile of the COPD population's decline. A Cox regression was used to assess the association between baseline accelerated FEV 1 decline and a composite CVD outcome over follow-up (myocardial infarction, ischaemic stroke, heart failure, atrial fibrillation, coronary artery disease and CVD mortality). The model was adjusted for age, sex, smoking status, body mass index, history of asthma, hypertension, diabetes, statin use, Modified Medical Research Council (mMRC) dyspnoea score, exacerbation frequency and baseline FEV 1 % predicted. 6110 COPD patients (16.8%) had a CVD event during follow-up; median length of follow-up was 3.6 years (interquartile range (IQR) 1.7–6.1 years). Median rate of FEV 1 decline was –19.4 mL·year −1 (IQR –40.5–1.9); 9095 patients (25%) had accelerated FEV 1 decline (&gt; –40.5 mL·year −1 ), 27 287 (75%) did not (≤ –40.5 mL·year −1 ). Risk of CVD and mortality was similar between patients with and without accelerated FEV 1 decline (HR adj 0.98, 95% CI 0.90–1.06). Corresponding risk estimates were 0.99 (95% CI 0.83–1.20) for heart failure, 0.89 (95% CI 0.70–1.12) for myocardial infarction, 1.01 (95% CI 0.82–1.23) for stroke, 0.97 (95% CI 0.81–1.15) for atrial fibrillation, 1.02 (95% CI 0.87–1.19) for coronary artery disease and 0.94 (95% CI 0.71–1.25) for CVD mortality. Rather, risk of CVD was associated with a mMRC score ≤2 and two or more exacerbations in the year prior. CVD outcomes and mortality were associated with exacerbation frequency and severity and increased mMRC dyspnoea score but not with accelerated FEV 1 decline.
1323P Natural killer cell activity as a prognostic biomarker in non-small cell lung cancer patients treated with check-point inhibitors
Authors: S.W.C. Wen, T.S. Hansen, L. Nederby, R.F. Andersen, C.H. Nyhus, L. Bertelsen, B.T. Sørensen, H. Hager, O. Hilberg, A. Jakobsen, T.F. Hansen
Journal: Annals of Oncology (2020)
Marine-inspired molecular mimicry generates a drug-free, but immunogenic hydrogel adhesive protecting surgical anastomosis
Authors: Jinjian Huang, Yungang Jiang, Ye Liu, Yanhan Ren, Ziyan Xu, Zongan Li, Yun Zhao, Xiuwen Wu, Jianan Ren
Journal: Bioactive Materials (2020)

Herein, we report the synthesis of a biomimic hydrogel adhesive that addresses the poor healing of surgical anastomosis. Dopamine-conjugated xanthan gum (Da-g-Xan) is fabricated using deep insights into the molecular similarity between mussels' adhesive and dopamine as well as the structural similarity between barnacle cement proteins and xanthan gum. The hydrogel mimics marine animals' adherence to wet tissue surfaces. Upon applying this adhesive to colonic anastomosis in a rat model, protective effects were shown by significantly improving the bursting pressure. Mechanistically, the architecture of Da-g-Xan hydrogel is maintained by dynamic intermolecular hydrogen bonds that allow the quick release of Da-g-Xan. The free Da-g-Xan can regulate the inflammatory status and induce type 2 macrophage polarization (M2) by specifically interacting with mannose receptors (CD206) revealed by RNA-sequencing and molecular binding assays. Consequently, an appropriate microenvironment for tissue healing is created by the secretion of chemokines and growth factors from M2 macrophages, strengthening the fibroblast migration and proliferation, collagen synthesis and epithelial vascularization. Overall, this study demonstrates an unprecedented strategy for generating an adhesive by synergistic mimicry inspired by two marine animals, and the results show that the Da-g-Xan adhesive augments native tissue regenerative responses, thus enabling enhanced recovery following surgical anastomosis.
490P Metastatic colorectal cancer derived organoids recapitulate genomic profile and treatment response of the original tumor
Authors: F. Papaccio, M.F. Gutierrez Bravo, M. Cabeza-Segura, F. Gimeno-Valiente, V. Gambardella, Z. Garzón-Lloría, B. García-Micó, M. Huerta, C. Martínez-Ciarpaglini, C. Alfaro-Cervello, L. Sabater, P. Lombardi, P. Rentero-Garrido, S. Zúñiga-Trejos, S. Roselló Keränen, T. Fleitas, N. Tarazona, D. Roda, A. Cervantes, J. Castillo
Journal: Annals of Oncology (2020)