tbuckley/cabot-search huggingface dataset:
Sorafenib maintenance in patients with FLT3-ITD acute myeloid leukaemia undergoing allogeneic haematopoietic stem-cell transplantation: an open-label, multicentre, randomised phase 3 trial
Authors: Li Xuan, Yu Wang, Fen Huang, Zhiping Fan, Yajing Xu, Jing Sun, Na Xu, Lan Deng, Xudong Li, Xinquan Liang, Xiaodan Luo, Pengcheng Shi, Hui Liu, Zhixiang Wang, Ling Jiang, Chunzi Yu, Xuan Zhou, Ren Lin, Yan Chen, Sanfang Tu, Xiaojun Huang, Qifa Liu
Journal: The Lancet Oncology (2020)
Evolution of Endoscopic Lesions in Steroid-Refractory Acute Severe Ulcerative Colitis Responding to Infliximab or Cyclosporine
Authors: David Laharie, Arnaud Bourreille, Julien Branche, Matthieu Allez, Yoram Bouhnik, Jerome Filippi, Frank Zerbib, Guillaume Savoye, Lucine Vuitton, Jacques Moreau, Aurelien Amiot, Laurent Beaugerie, Elena Ricart, Olivier Dewit, Antonio Lopez-Sanroman, Mathurin Fumery, Franck Carbonnel, Anthony Buisson, Benoit Coffin, Xavier Roblin, Gert van Assche, Maria Esteve, Martti Farkkila, Javier P. Gisbert, Philippe Marteau, Stephane Nahon, Martine de Vos, Laurent Peyrin-Biroulet, Jean-Yves Mary
Journal: Clinical Gastroenterology and Hepatology (2020)
THU0534 LUNG ULTRASOUND IN PATIENTS WITH SECONDARY INTERSTITIAL LUNG DISEASES
Authors: E. Kirillova, N. Shamsutdinova, G. Nurullina
Journal: Annals of the Rheumatic Diseases (2020)

Background: Currently, lung ultrasound (LUS) is increasingly used in rheumatology. Objectives: To evaluate the relationship between lung ultrasound and pulmonary function and disease activity in patients with rheumatic diseases with secondary lung involvement. Methods: Thirty patients with rheumatic diseases were included in the study, who, according to the data of the high-resolution RCT of lungs (64-slice CT system Philips Diamond Select Brilliance), showed interstitial lung involvement as a type of nonspecific interstitial pneumonia. In 4 patients, mixed connective tissue disease (MCTD) was diagnosed, 20 had systemic vasculitis (SV), and 6 had rheumatoid arthritis (RA). The mean age of the patients was 56,55 ± 10,59, the duration of the disease was 2,3 ± 1,2 years. All patients underwent a standard clinical examination, the following indices and scales were used to assess the activity of the underlying disease: VDI damage index, Bermingham systemic vasculitis activity scale (BVAS), RA activity scale (DAS 28-CRP). The functional state of the lungs was assessed using spirometry, bodipletismography, gas diffusion “single breath”. LUS was carried out for the evaluation of the location and number of B-lines on both right and left hemithoraces using commercially available echographic equipment with a 5-12 MHz linear transducer (Accuvix A30, Samsung Medison). Results: Most patients had an average number of B-lines 24,5[11,5;34,0]. Тhere were no significant differences in the number of В-lines between groups of patients of different nosologies. The total number of В-lines correlated with the index of activity of systemic vasculitis BVAS (р&lt;0,05; r=0,83). There were no statistically significant correlations with clinical manifestations of pulmonary involvement. Conclusion: Lung ultrasound may be useful in screening secondary lung involvement in patients with rheumatic diseases with high activity. References: [1]Dietrich CF, Mathis G, Blaivas M, Volpicelli G, Seibel A, Wastl D, Atkinson NS, Cui XW, FanM, Yi D. Lung B-line artefacts and their use. J Thorac Dis 2016;8(6):1356-1365. doi: 10.21037/jtd.2016.04.55 [2]Tatiana Barskova, Luna Gargani, Serena Guiducci, et al. Lung ultrasound for the screening of interstitial lung disease in very early systemic sclerosis Ann Rheum Dis 2013 72: 390-395 originally published online May 15 2012 doi: 10.1136/annrheumdis-2011-201072 Disclosure of Interests: None declared
Abstract 14789: Impact of Genetic Analysis on the mode of Death in Genotyped Hypertrophic Cardiomyopathy
Authors: Noboru Fujino, Tetsuo Konno, Kenshi Hayashi, Katsuharu Uchiyama, Kenji Sakata, Takashi Fujita, Toyonobu Tsuda, Yoji Nagata, Hidekazu Ino, Masakazu Yamagishi
Journal: Circulation (2011)

Background: Hypertrophic cardiomyopathy (HCM) is a disease of sarcomere. Sudden cardiac death in young subjects and heart failure in old subjects are the biggest issues for the management of HCM. I...
Avelumab for the treatment of relapsed or refractory extranodal NK/T-cell lymphoma: an open-label phase 2 study
Authors: Seok Jin Kim, Jing Quan Lim, Yurike Laurensia, Junhun Cho, Sang Eun Yoon, Ji Young Lee, Kyung Ju Ryu, Young Hyeh Ko, Youngil Koh, Duck Cho, Soon Thye Lim, Marie Beck Enemark, Francesco D’Amore, Mette Bjerre, Choon Kiat Ong, Won Seog Kim
Journal: Blood (2020)
The Proteogenomic Landscape of High Hyperdiploid and ETV6/RUNX1-Positive Childhood Acute Lymphoblastic Leukemia
Authors: Minjun Yang, Mattias Vesterlund, Ioannis Siavelis, Eleanor Woodward, Naveen Ravi, Henrik Lilljebjörn, Thoas Fioretos, Janne Lehtiö, Kajsa Paulsson
Journal: Blood (2017)
Pretreatment Nutritional Status and Cardiovascular Risk Factors Affect Survival of Diffuse Large B-Cell Lymphoma Patients Treated with Immunochemotherapy
Authors: Ji Hyun Lee, Sung Yong Oh, Ho Sup Lee, Jae-Cheol Jo, Yunsuk Choi, Won-Sik Lee, Kwon Kyung A, Yoojin Lee, Ho-Jin Shin
Journal: Blood (2017)
BETs that cover the spread from acquired to heritable heart failure
Authors: Michael Alexanian, Saptarsi M. Haldar
Journal: Journal of Clinical Investigation (2020)

Heart failure (HF) with reduced contractile function is a common and lethal syndrome in which the heart cannot pump blood to adequately meet bodily demands, resulting in high mortality despite the current standard of care. In modern societies, the most common drivers of HF are ischemic heart disease and hypertension. However, in a substantial subset of cases, patients present with dilated and poorly contracting hearts without evidence of common inciting stressors, a syndrome called dilated cardiomyopathy (DCM). Genome sequencing has identified a host of deleterious germline variants in key cardiomyocyte genes as causes of heritable DCM, including mutations in LMNA, which encodes the nuclear lamina-associated protein lamin A/C. In this issue of the JCI, Auguste et al. generate a mouse model of DCM in which they delete Lmna in cardiomyocytes and discover that bromodomain and extraterminal (BET) protein activation is a druggable epigenetic mechanism of disease pathogenesis in this heritable HF syndrome.
Multifunctional oncolytic nanoparticles deliver self-replicating IL-12 RNA to eliminate established tumors and prime systemic immunity
Authors: Yingzhong Li, Zhijun Su, Weiyu Zhao, Xinfu Zhang, Noor Momin, Chengxiang Zhang, K. Dane Wittrup, Yizhou Dong, Darrell J. Irvine, Ron Weiss
Journal: Nature Cancer (2020)
A compendium of mutational cancer driver genes
Authors: Francisco Martínez-Jiménez, Ferran Muiños, Inés Sentís, Jordi Deu-Pons, Iker Reyes-Salazar, Claudia Arnedo-Pac, Loris Mularoni, Oriol Pich, Jose Bonet, Hanna Kranas, Abel Gonzalez-Perez, Nuria Lopez-Bigas
Journal: Nature reviews. Cancer (2020)
Prenatal Prediction of Risk of the Fetal Hydantoin Syndrome
Authors: Bruce A. Buehler, Duane Delimont, Michael van Waes, Richard H. Finnell
Journal: New England Journal of Medicine (1990)

The well-known teratogenicity of several anticonvulsant medications is associated with an elevated level of oxidative metabolites that are normally eliminated by the enzyme epoxide hydrolase. In this study, we attempted to determine whether infants who are at risk for congenital malformations could be identified prenatally by the measurement of epoxide hydrolase activity.
Trends in clinical profiles, organ support use and outcomes of patients with cancer requiring unplanned ICU admission: a multicenter cohort study
Authors: Fernando G. Zampieri, Thiago G. Romano, Jorge I. F. Salluh, Leandro U. Taniguchi, Pedro V. Mendes, Antonio P. Nassar, Roberto Costa, William N. Viana, Marcelo O. Maia, Mariza F. A. Lima, Sylas B. Cappi, Alexandre G. R. Carvalho, Fernando V. C. De Marco, Marcelo S. Santino, Eric Perecmanis, Fabio G. Miranda, Grazielle V. Ramos, Aline R. Silva, Paulo M. Hoff, Fernando A. Bozza, Marcio Soares
Journal: Intensive Care Medicine (2020)
Management of post-acute covid-19 in primary care
Authors: Trisha Greenhalgh, Matthew Knight, Christine A’Court, Maria Buxton, Laiba Husain
Journal: BMJ (2020)

What you need to know• Management of covid-19 after the first three weeks is currently based on limited evidence • Approximately 10% of people experience prolonged illness after covid-19 • Many such patients recover spontaneously (if slowly) with holistic support, rest, symptomatic treatment, and gradual increase in activity • Home pulse oximetry can be helpful in monitoring breathlessness • Indications for specialist assessment include clinical concern along with respiratory, cardiac, or neurological symptoms that are new, persistent, or progressive the
Adoptive Immunotherapy with Cord Blood (CB) Grafts Targeting Shared Inherited Paternal Antigens (IPA) and/or Non-Inherited Maternal Antigens (NIMA) during Induction Treatment for High Risk Myeloid Malignancies: Safety and Preliminary Results
Authors: Usama Gergis, Koen Van Besien, Emeline Masson Frenet, Tsiporah B. Shore, Sebastian A. Mayer, Adrienne A. Phillips, Jingmei Hsu, Gail J. Roboz, Ellen K Ritchie, Joseph Scandura, Sangmin Lee, Pinkal Desai, Michael Samuel, Jeffrey Ball, Maria S. Albano, Rodica Ciubotariu, Ludy Dobrila, Cynthia Romeo, Andromachi Scaradavou
Journal: Blood (2017)
Dental procedure aerosols and COVID-19
Authors: Joel B Epstein, Kenneth Chow, Richard Mathias
Journal: The Lancet Infectious Diseases (2020)

providers to be compared with infection incidence in the community.To date there are no reported clusters of respiratory-transmitted diseases, including severe acute respiratory syndrome coronavirus and SARS-CoV-2, in dental providers or patients in a dental setting.We declare no competing interests.
ASO慢性完全閉塞(CTO)病変に対する膝か動脈アプローチPTAの有用性
Authors: 飯田修, 南都伸介, 上松正朗, 大原知樹, 両角隆一, 小谷順一, 粟田政樹, 肥後修一朗, 大西俊成
Journal: Circulation (2004)
The COVID-19 Outbreak Negatively Affects the Delivery of Care for Patients With Diabetic Foot Ulcers
Authors: Chao Liu, Jiaxing You, Weifen Zhu, Yixin Chen, Shengyun Li, Yuefeng Zhu, Shujuan Ji, Ying Wang, Hongye Li, Lin Li, Shunwu Fan
Journal: Diabetes Care (2020)

Diabetic foot ulcers (DFUs) represent the most frequent diabetes-related cause for hospitalization (1). Currently, the coronavirus disease 2019 (COVID-19) pandemic is likely to pose a threat to the delivery of care, leading to some unintended consequences. We aimed to determine the impact of the COVID-19 outbreak on patients with DFUs at a multidisciplinary center in China.

In the first part of this study, an interrupted time-series design was applied to estimate the trends in hospitalization for patients with DFUs before the COVID-19 outbreak to generate the predicted value in 2020. Monthly hospitalization records from 2016 to 2019 were abstracted to fit the autoregressive integrated moving-average model. We compared the prediction with the actual values in the first trimester of 2020 to project changes in trends that were assumed to have been caused by the outbreak. This analysis showed significant reductions in January and February, as indicated by actual hospitalizations being significantly lower than the lower boundary of 95% CI of predicted values. The number of hospitalizations in March rebounded and was close to the usual level (Fig. 1).



Figure 1 
Actual and predicted values of monthly hospitalizations for patients with DFUs. The numbers of inpatients with DFU episodes were 343 in 2016, 376 in 2017, 403 …
Comparison of endoscopic ultrasound-guided fine-needle biopsy versus fine-needle aspiration for genomic profiling and DNA yield in pancreatic cancer: a randomized crossover trial
Authors: Pujan Kandel, Aziza Nassar, Victoria Gomez, Massimo Raimondo, Timothy A. Woodward, Julia E. Crook, Natalie S. Fares, Michael B. Wallace
Journal: Endoscopy (2020)

Abstract Background National guidelines recommend genomic profiling of tumor tissue to guide precision therapy. We compared the specimen adequacy for genomic profiling and yield of DNA between endoscopic ultrasound (EUS)-guided fine-needle biopsy (FNB) and EUS-guided fine-needle aspiration (FNA). Methods In our tandem, randomized controlled trial, consecutive patients undergoing EUS for evaluation of pancreatic masses underwent both conventional EUS-FNA with a 25-gauge needle and paired EUS-FNB (19 or 22-gauge needle), with the order randomized (EUS-FNA first followed by EUS-FNB, or vice versa). A minimum of one pass with each needle was obtained for histology. Second and third passes were performed to collect DNA. Specimens were evaluated by a cytopathologist blinded to the needle type. Specimen adequacy for genomic profiling was calculated based on FoundationOne clinical diagnostic (CDx) adequacy requirements. We compared the adequacy for genomic profiling DNA (quantity) and histology yields with both needles. Results Analysis included 50 patients (25 men; mean age 68 [standard deviation (SD) 13] years), with a mean lesion size of 38 (SD 17) mm; 37 lesions (74 %) were pancreatic ductal adenocarcinoma (PDAC). The mean DNA concentrations in PDAC by FNB and FNA needles were 5.930 (SD 0.881) µg/mL vs. 3.365 (SD 0.788) µg/mL, respectively (P = 0.01). The median standardized histology score per pass with EUS-FNB was 5 (sufficient for histology) and for EUS-FNA was 2 (enough for cytology). Specimen adequacy for genomic profiling and yield of DNA was significantly higher with FNB than with FNA needles. Conclusions In this study, adequacy for genomic profiling, DNA, and histology yield were considerably superior using an EUS-FNB needle compared with an EUS-FNA needle.
Breast Cancer Screening and Health Care Costs—Reply
Authors: Natalia Kunst, Cary P. Gross
Journal: JAMA Internal Medicine (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Gene Expression Profiling (GEP) Is More Prognostic of OS and Post-ASCT PFS Compared to FISH in High-Risk Multiple Myeloma — a Single Center Experience
Authors: Miguel Gonzalez Velez, Narjust Duma, Badal Thakkar, Ning Dong, Giselle Suero, David Siegel, Joshua R Richter, David H. Vesole, Noa Biran
Journal: Blood (2017)
Abstract B61: Improvement of physical activity training in childhood acute lymphoblastic leukemia survivors: New specific equation to predict the peak oxygen uptake from the six-minute walk test
Authors: Maxime Caru, Jennifer Labonté, Valérie Lemay, Simon Drouin, Laurence Bertout, Gregor Andelfinger, Nathalie Alos, Maja Krajinovic, Caroline Laverdière, Daniel Sinnett, Daniel Curnier
Journal: Cancer Research (2020)

Abstract Purpose: The six-minute walk test (6MWT) is the most widely used test to assess the functional capacity of cancer patients. However, it is reported that the actual equations cannot accurately predict oxygen uptake (VO2 value) or walk distance (6MWD) in cancer survivors. Because of the importance for clinicians and physiologists to have a validated VO2 or 6MWD equation from the 6MWT to observe the predicted survivors’ value, we focused on the validation of a standard and specific equation to predict VO2 peak and 6MWD. Methods: A total of 200 survivors were enrolled in this study, among whom 168 participants underwent a cardiopulmonary exercise test and a 6MWT. They also completed a physical activity questionnaire. Participants were randomly divided in two groups to predict the equations (n=118 (70%)) and to validate them (n=50 (30%)). Multiple linear regression analyses were used to determine a new prediction equation for VO2 peak and 6MWD from 6MWT. Bland and Altman methods were used to assess the accuracy. Results: Our findings showed that without specific variables in the VO2 peak equation, the mean bias was of 2.67 mL.kg-1.min-1 and of 2.51 mL.kg-1.min-1 with specific variables. We observed a better accuracy compared to previously published equations, which reported a mean bias of 12.09 mL.kg-1.min-1. The same results were observed for the 6MWD. Conclusion: This was the first study to predict VO2 peak and 6MWD using clinical and specific variables related to the disease. Every health care professional and exercise physiologist should use both our validated equations to provide a better adapted physical training. Our findings strengthen the need to evaluate survivors’ cardiorespiratory fitness in the care process. Citation Format: Maxime Caru, Jennifer Labonté, Valérie Lemay, Simon Drouin, Laurence Bertout, Gregor Andelfinger, Nathalie Alos, Maja Krajinovic, Caroline Laverdière, Daniel Sinnett, Daniel Curnier. Improvement of physical activity training in childhood acute lymphoblastic leukemia survivors: New specific equation to predict the peak oxygen uptake from the six-minute walk test [abstract]. In: Proceedings of the AACR Special Conference on the Advances in Pediatric Cancer Research; 2019 Sep 17-20; Montreal, QC, Canada. Philadelphia (PA): AACR; Cancer Res 2020;80(14 Suppl):Abstract nr B61.
Associations of Sleep-disordered Breathing and Insomnia with Incident Hypertension and Diabetes. The Hispanic Community Health Study/Study of Latinos
Authors: Xiaoyu Li, Daniela Sotres-Alvarez, Linda C. Gallo, Alberto R. Ramos, Larissa Aviles-Santa, Krista M. Perreira, Carmen R. Isasi, Phyllis C. Zee, Kimberly L. Savin, Neil Schneiderman, Sylvia Wassertheil-Smoller, Tamar Sofer, Martha Daviglus, Susan Redline
Journal: American Journal of Respiratory and Critical Care Medicine (2020)

Rationale: Sleep disorders are associated with hypertension and diabetes, which are primary risk factors for cardiovascular diseases and mortality. It is important to understand these associations in Hispanic/Latino individuals, in whom cardiovascular death is the leading cause of mortality.Objectives: To investigate the prospective associations of sleep-disordered breathing (SDB) and insomnia with incident hypertension and diabetes among U.S. Hispanic/Latino people over 6 years of follow-up and to assess potential sex differences in these associations.Methods: Data from 11,623 Hispanic/Latino participants in the Hispanic Community Health Study/Study of Latinos (visit 1, 2008–2011; visit 2, 2014–2017) were analyzed using survey logistic regression models, adjusting for potential confounders.Measurements and Main Results: SDB (apnea–hypopnea index of 5 or more) and insomnia (Women’s Health Initiative Insomnia Rating Scale of 9 or more) were measured at baseline. Incident hypertension (stage 2 or greater) and diabetes were defined according to national guidelines. In the target population, 52.6% were women, with a mean age of 41.1 ± 14.9 years at baseline. SDB was associated with 1.54 higher adjusted odds of incident hypertension (95% confidence interval [CI], 1.18–2.00) and 1.33 higher odds of incident diabetes (95% CI, 1.05–1.67) compared with no SDB. Insomnia was associated with incident hypertension (odds ratio, 1.37; 95% CI, 1.11–1.69) but not with diabetes. The association between insomnia and incident hypertension was stronger among men than among women.Conclusions: SDB was associated with incident hypertension and diabetes. Insomnia was associated with incident hypertension. These findings support the importance of sleep disorders as modifiable targets for disease prevention and reduction.
Isolation, identification, and characterization of the human airway ligand for the eosinophil and mast cell immunoinhibitory receptor Siglec-8
Authors: Anabel Gonzalez-Gil, T. August Li, Ryan N. Porell, Steve M. Fernandes, Haley E. Tarbox, Hyun Sil Lee, Kazuhiro Aoki, Michael Tiemeyer, Jean Kim, Ronald L. Schnaar
Journal: Journal of Allergy and Clinical Immunology (2020)
Virus-like nanoparticle as a co-delivery system to enhance efficacy of CRISPR/Cas9-based cancer immunotherapy
Authors: Qi Liu, Chun Wang, Yadan Zheng, Yu Zhao, Ying Wang, Jialei Hao, Xinzhi Zhao, Kaikai Yi, Linqi Shi, Chunsheng Kang, Yang Liu
Journal: Biomaterials (2020)
What makes a great clinical trial? Exploring the features of five important physiotherapy trials
Authors: Anita B Amorim, Joshua R Zadro, Anne M Moseley
Journal: British Journal of Sports Medicine (2020)

Some clinical trials are landmark trials that grab international attention. Others fail to excite. What is the difference between a great trial and a mediocre trial? A recent initiative provides some insights.

The Physiotherapy Evidence Database (PEDro) is a free, online database of randomised trials, systematic reviews and practice guidelines in physiotherapy. To mark PEDro’s 20th anniversary, physiotherapists worldwide were invited to nominate randomised trials published in 2014–2019 that answered important clinical questions in a robust and innovative way (online supplementary file A). A panel of experts in clinical trials judged the nominations and established the top five trials: LIPPSMAck POP,1 SARAH,2 AVERT,3 HIHO4 and UK FASHIoN5 (table 1). The lessons learnt from the top five trials are relevant to trials in sports and exercise medicine because they all tested exercise interventions against other models of care (ie, phase III).### Supplementary data

[bjsports-2020-102088supp001.pdf]

View this table:

Table 1 
Description of the top five trials



Not every sports physiotherapist would think about upper abdominal surgery, but ‘Exercise is Medicine’ and physiotherapy can play a major role in preventing serious, common and costly pulmonary complications. LIPPSMAck POP1 demonstrated that a single …
A Validated Risk Model for Overall Survival in Relapsed/Refractory Chronic Lymphocytic Leukemia Applicable to Patients Treated with Novel Therapies and Standard of Care
Authors: Jacob D. Soumerai, Ai Ni, Mohamed Darif, Anil Londhe, Guan Xing, Julie Huang, Ming Lin, John C. Byrd, Asher A. Chanan-Khan, Richard R. Furman, Michael Hallek, Peter Hillmen, Jeffrey Jones, Jeffrey P. Sharman, Lucille Ferrante, Vijay Reddy, Lyndah K. Dreiling, Henry Adewoye, Ronald Dubowy, Angela Howes, Danelle F. James, Andrew D. Zelenetz
Journal: Blood (2017)