tbuckley/cabot-search huggingface dataset:
Pearls and Pitfalls of Quantitative Software Analysis of Dopamine Transporter SPECT
Authors: Raza Mushtaq, Matthew D. Kay, Laura Steinmeyer, Devdutta Warhadpande, Phillip H. Kuo
Journal: Clinical Nuclear Medicine (2020)

Abstract Dopamine transporter SPECT with 123 I-N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) nortropane ( 123 I-ioflupane) aids in the diagnosis of parkinsonian syndrome by demonstrating loss of striatal dopamine transporters, proportional to nigrostriatal dopaminergic neuronal loss. Quantitative software analysis (QSA) is a helpful adjunct to visual interpretation. An atlas of pearls and pitfalls of QSA is presented. Examples include correction for head tilt/orientation, scaling artifacts, and detection of balanced loss of activity. Additional examples are provided where QSA can potentially fail such as patient variation and vascular disease.
Training of Male and Female Surgical Residents
Authors: Mina M. T. Ip
Journal: JAMA Surgery (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Drug Prices, Rebates, and Discounts
Authors: Anna Anderson-Cook, Andrea Noda
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SAT0467 LOW SERUM OSTEOCALCIN LEVELS ARE ASSOCIATED WITH THE PRESENCE OF DIABETES MELLITUS IN GLUCOCORTICOID TREATED PATIENTS.
Authors: H. Florez, J. Hernández-Rodríguez, J. L. Carrasco, S. Prieto-González, X. Filella, A. Monegal, N. Guañabens, P. Peris
Journal: Annals of the Rheumatic Diseases (2020)

Background: Increasing evidence indicates that osteocalcin (OC) is involved in the regulation of glucose homeostasis. Glucocorticoid (GC) treatment is associated with impaired osteoblast function and decreased OC levels and also with the development of CG-induced diabetes mellitus (GIDM). However, whether decreased OC levels in GC-treated subjects contribute to GIDM is not well known. Objectives: To analyse whether OC levels in GC-treated patients are associated with the presence of GIDM. Methods: 127 patients (aged 62±18years, 63% women) on GC treatment for autoimmune diseases (≥5mg/day, &gt;3 months) were included. Clinical and anthropometric data were analysed, including the GC dose and treatment duration, presence of GIDM, fragility fractures, densitometric osteoporosis and bone formation (OC, bone alkaline phosphatase [BAP], PINP) and resorption markers (urinary NTX, serum CTX). The cut-offs of each bone marker for the presence of GIDM were estimated and optimized with the Youden index and included in the logistic regression analysis (adjusted for BMI, age and GC doses). Results: 17.3% of patients presented GIDM. Diabetic subjects were older (70.5±12.2 vs. 59.6±18.4, p=0.001) and had a higher BMI than non-diabetics (30±5.2 vs. 26±4.2, p=0.002). No differences were observed in GC dose or duration or in the presence of vertebral fractures. Diabetics showed lower levels of OC (7.57±1.01 vs. 11.56±1; p&lt;0.001), PINP (21.48±1.01 vs. 28.39±1; p=0.0048), NTx (24.91±1.01 vs. 31.7±1; p=0.036) and CTX (0.2±1.01 vs. 0.3±1; p=0.0016) with similar BAP values. The best discriminating cut-offs for GIDM presence were: &lt;9.25ng/mL for OC, &lt;24ng/mL for PINP, &lt;27.5nMol/mM for NTX and &lt;0.25ng/mL for CTX. On multivariate analysis OC (&lt;9.25) was the only marker related to the presence of GIDM (OR 6.1; CI95% 1.87-19.89; p=0.001). Conclusion: Decreased OC levels in GC-treated patients are associated with an increased risk of GIDM, a finding that was not observed with other bone turnover markers, further confirming the involvement of OC in the glucose homeostasis regulation in this entity. Disclosure of Interests: None declared
FRI0650-HPR SEXUAL DYSFUNCTION IN WOMEN WITH SYSTEMIC LUPUS ERYTHEMATOSUS
Authors: G. V. Espasa, L. Gonzalez Lucero, Y. Soria Curi, A. L. Barbaglia, S. M. Mazza, M. L. Leguizamón, M. Pera, H. R. Sueldo, M. C. Bertolaccini, M. Santana, L. M. Galindo, V. I. Bellomio
Journal: Annals of the Rheumatic Diseases (2020)

Background: Sexual dysfunction is the alteration in one or several phases of sexual activity (desire, excitement, plateau, orgasm and resolution), which can culminate in frustration, pain and a decrease in the frequency of sexual intercourse. There are few studies that associate sexual dysfunction with Systemic Lupus Erythematosus (SLE) due to the difficulty in assessing it and its multifactorial cause. Objectives: Determine the frequency of sexual dysfunction and analyze associated factors in patients with SLE. Methods: A descriptive cross-sectional study was conducted. We included patients who attended the Rheumatology unit between May and July 2019; over 18 years of age, with a diagnosis of SLE according to the ACR 1997 and / or SLICC 2012 criteria, and healthy patients matched by age as control. Demographic and disease-related variables were studied. The DASS-21 (Depression Anxiety Stress Scale) scale that evaluates depression, anxiety and stress, and the Female Sexual Function Index (FSFI) that assesses 6 domains (desire, excitement, lubrication, orgasms, satisfaction and pain) were applied with a cut-off point ≤ 26.5 to define sexual dysfunction. Women over 50 years old, with secondary Sjogren’s syndrome, menopause, severe depression and illiterate patients were excluded. Results: One hundred and twenty three women were included (60 with SLE and 63 controls), with a mean age of 34.3 ± 8.3 and 31.7 ± 4.4 years respectively. The prevalence of sexual dysfunction in the SLE group was 71.7%; 95% CI = [58.5 – 82.5], and 23.8%, 95% CI = [13.9 – 36.2] in healthy patients. There were significant differences in all domains of sexual function between women with SLE and healthy group. In the desire, excitement and pain domains the differences were notable. The total FSFI score in patients with SLE was 18.2 ± 11.2 and in healthy women 28.3 ± 6.9 (p=0.001). Stress, anxiety and depression were observed in 58.4%, 58.3% and 50% of women with SLE and 19%, 20.6% and 28.5% of healthy women respectively (p=0.001). No association was found between sexual dysfunction and age, age at diagnosis, disease activity or treatment (pNS). No association was found in patients with SLE when analyzing the effect of sexual dysfunction in stress, depression and anxiety variables, in opposition to the healthy group (p&lt;0.05). Conclusion: The prevalence of sexual dysfunction in patients with SLE was high (71.7%). Depression, Anxiety, and Stress were not decisive variables in Sexual Dysfunction. Disclosure of Interests: None declared
Author Correction: PENet—a scalable deep-learning model for automated diagnosis of pulmonary embolism using volumetric CT imaging
Authors: Shih-Cheng Huang, Tanay Kothari, Imon Banerjee, Chris Chute, Robyn L. Ball, Norah Borus, Andrew Huang, Bhavik N. Patel, Pranav Rajpurkar, Jeremy Irvin, Jared Dunnmon, Joseph Bledsoe, Katie Shpanskaya, Abhay Dhaliwal, Roham Zamanian, Andrew Y. Ng, Matthew P. Lungren
Journal: npj Digital Medicine (2020)

[This corrects the article DOI: 10.1038/s41746-020-0266-y.].
Authors’ response: COVID-19: how accurate are seroprevalence studies?
Authors: Irene Cassaniti, Elena Percivalle, Antonella Sarasini, Giuseppe Cambiè, Gherard Batisti Biffignandi, Danilo Cereda, Fausto Baldanti
Journal: Eurosurveillance (2020)

Preview this article: Authors' response: COVID-19: how accurate are seroprevalence studies?, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/25/30/eurosurv-25-30-5-1.gif
Actionable health app evaluation: translating expert frameworks into objective metrics
Authors: Sarah Lagan, Patrick Aquino, Margaret R. Emerson, Karen Fortuna, Robert Walker, John Torous
Journal: npj Digital Medicine (2020)

Abstract As use and availability of mobile health apps have increased, so too has the need for a thorough, accessible framework for app evaluation. The American Psychiatric Association’s app evaluation model has emerged as a way to critically assess an app by considering accessibility, privacy and security, clinical foundation, engagement, and interoperability; however, there is no centralized database where users can view how various health apps perform when assessed via the APA model. In this perspective, we propose and outline our effort to translate the APA’s model for the evaluation of health apps into a set of objective metrics that can be published online, making the framework actionable and accessible to a broad audience. The questions from the APA model were operationalized into 105 objective questions that are either binary or numeric. These questions serve as the foundation of an online database, where app evaluation consists of answering these 105 questions and can be crowdsourced. While the database has yet to be published and crowdsourced, initial internal testing demonstrated excellent interrater reliability. The database proposed here introduces a public and interactive approach to data collection that is guided by the APA model. The published product enables users to sort through the many mobile health apps and filter them according to individual preferences and priorities, making the ever-growing health app market more navigable.
Characteristics and Quality of US Nursing Homes Reporting Cases of Coronavirus Disease 2019 (COVID-19)
Authors: Paula Chatterjee, Sheila Kelly, Mingyu Qi, Rachel M. Werner
Journal: JAMA Network Open (2020)

Jose F. Figueroa, MD, MPH; Rishi K. Wadhera, MD, MPP; Irene Papanicolas, PhD; Kristen Riley, BA; Jie Zheng, PhD; E. John Orav, PhD; Ashish K. Jha, MD, MPH
Immune monitoring of interleukin-7 compassionate use in a critically ill COVID-19 patient
Authors: Guillaume Monneret, Donatien de Marignan, Rémy Coudereau, Céline Bernet, Florence Ader, Emilie Frobert, Morgane Gossez, Sébastien Viel, Fabienne Venet, Florent Wallet
Journal: Cellular and Molecular Immunology (2020)
A biomimetic antitumor nanovaccine based on biocompatible calcium pyrophosphate and tumor cell membrane antigens
Authors: Minghui Li, Mengmeng Qin, Ge Song, Hailiang Deng, Dakuan Wang, Xueqing Wang, Wenbing Dai, Bing He, Hua Zhang, Qiang Zhang
Journal: Asian Journal of Pharmaceutical Sciences (2020)

Currently, the cancer immunotherapy has made great progress while antitumor vaccine attracts substantial attention. Still, the selection of adjuvants as well as antigens are always the most crucial issues for better vaccination. In this study, we proposed a biomimetic antitumor nanovaccine based on biocompatible nanocarriers and tumor cell membrane antigens. Briefly, endogenous calcium pyrophosphate nanogranules with possible immune potentiating effect are designed and engineered, both as delivery vehicles and adjuvants. Then, these nanocarriers are coated with lipids and B16-OVA tumor cell membranes, so the biomembrane proteins can serve as tumor-specific antigens. It was found that calcium pyrophosphate nanogranules themselves were compatible and possessed adjuvant effect, while membrane proteins including tumor associated antigen were transferred onto the nanocarriers. It was demonstrated that such a biomimetic nanovaccine could be well endocytosed by dendritic cells, promote their maturation and antigen-presentation, facilitate lymph retention, and trigger obvious immune response. It was confirmed that the biomimetic vaccine could induce strong T-cell response, exhibit excellent tumor therapy and prophylactic effects, and simultaneously possess nice biocompatibility. In general, the present investigation might provide insights for the further design and application of antitumor vaccines.
Kinetics and performance of the Abbott architect SARS-CoV-2 IgG antibody assay
Authors: Fergus Hamilton, Peter Muir, Marie Attwood, Alan Noela Barry Vipond, Richard Hopes, Ed Moran, Nick Maskell, Deborah Warwick, Mahableshwar Albur, Jonathan Turner, Alasdair MacGowan, David Arnold
Journal: Journal of Infection (2020)
CD84 Links T Cell and Platelet Activity in Cerebral Thrombo-Inflammation in Acute Stroke
Authors: Michael K. Schuhmann, Guido Stoll, Michael Bieber, Timo Vögtle, Sebastian Hofmann, Vanessa Klaus, Peter Kraft, Mert Seyhan, Alexander M. Kollikowski, Lena Papp, Peter U. Heuschmann, Mirko Pham, Bernhard Nieswandt, David Stegner
Journal: Circulation Research (2020)

Ischemic stroke is a leading cause of morbidity and mortality worldwide. Recanalization of the occluded vessel is essential but not sufficient to guarantee brain salvage. Experimental and clinical data suggest that infarcts often develop further due to a thromboinflammatory process critically involving platelets and T cells, but the underlying mechanisms are unknown.
Distinct roles for calcium signaling in apoptosis of prostate and cervical cancer cells exposed to diindolylmethane
Authors: John Savino, Jodi Evans, Dorianne Rabinowitz, Karen Auborn, Timothy Carter
Journal: Cancer Research (2005)

1739  Diindolylmethane (DIM), a dietary phytochemical derived from indole-3-carbinol (I3C) in cruciferous vegetables, causes growth arrest and apoptosis of cancer cells in vitro. At micromolar concentrations, DIM induces endoplasmic reticulum (ER) stress1,2, and pre-treatment of cancer cells with thapsigargin (TG), a specific inhibitor of the sarcoplasmic/ER calcium-dependent ATPase and itself an inducer of ER stress, enhances DIM cytotoxicity. Increased intracellular calcium [Ca2+]i has been implicated as an apoptotic signal in several experimental and pathophysiologic models, including ER-stress; however, increased [Ca2+ ]i was not required to produce apoptosis after exposure of LnCaP prostate cancer cells to I3C3. We asked whether elevated [Ca2+]i is required for cytotoxicity of DIM and TG in two cancer cells lines, C33A (cervical), and DU145, (prostate). DIM, like TG, rapidly mobilized ER Ca2+ (measured by real-time Fura2 fluorescence). We tested the ability of DIM, TG, and DIM + TG to cause apoptosis under conditions that prevented elevation of [Ca2+ ]i (“clamp”)3. In unclamped C33A cells, 25μM DIM alone caused no detectable increase in basal levels of apoptosis (measured by nucleosome-release ELISA) after 24h, whereas thapsigargin alone increased apoptosis 3-fold, and the combination of 25μM DIM + TG caused a further, 4-fold, increase. Clamping C33A cells slightly increased basal apoptosis, but did not interfere with apoptosis induced by TG or by TG + DIM. In contrast to C33A, Ca2+ clamping significantly reduced apoptosis of DU145 cells induced by all treatments; the combination of TG + DIM acted synergistically to cause a 16-fold increase in nucleosome release in DU145 that was attenuated >50% by Ca2+ clamping. Inhibitor studies appear to rule out CaM kinase II and protein phosphatase 2A as potential mediators of the Ca2+-dependent apoptotic signal in DU145. The different responses of C33A and DU145 to perturbations in calcium homeostasis suggest either that DIM induces apoptosis by different mechanisms in these two cell lines, or that calcium mobilization activated survival pathways in C33A, but not in DU145. Apoptosis of C33A appeared to be independent of increased [Ca2+]i , suggesting that depletion of ER Ca2+ stores may be sufficient for killing by TG and DIM, whereas induction of apoptosis in DU145 requires elevated [Ca2+]i for full response. Further work is ongoing to define these different mechanisms, and to determine the role(s) of calcium-dependent apoptotic signaling in the cytotoxic effects of DIM on tumor cells. Supported in part by grants CA73850 and CA100967. 1. Carter, TH, Liu, K, Ralph, WJ, Jr. et al., (2002) J. Nutrition 132, 3314-3324. 2. Sun, S-S, Han, J, Ralph, WJ, Jr, et al., (2003) Cell Stress and Chap. 9, 1355-8145. 3. Wertz, IE and Dixit, VM, (2000) J. Biol. Chem. 275, 11470-11477.
Abstract 13840: Cardiogenic Shock Complicating ST-Elevated Myocardial Infarction in China: Data From the China Acute Myocardial Infarction Registry
Authors: Guihao Chen, Jin-gang Yang, Yuejin Yang, Chunyan Tian, Yang Wang, Haiyan Xu
Journal: Circulation (2017)

Introduction: Cardiogenic shock (CS) remains the leading cause of death in patients with ST-Elevated Myocardial Infarction(STEMI) and no data have investigated the situation of CS complicating STEM...
Optimizing pump speed promotes synergy between left ventricular assist device and right ventricular function in patients on long-term mechanical assistance
Authors: L.E.L.E. Couperus, V. Delgado, H.F. Verwey, L.F. Tops, M.J.H. Khidir, M. Palmen, R.J.M. Klautz, M.J. Schalij, S.L.M.A. Beeres
Journal: European Journal of Heart Failure (2015)
4DCT-Derived Endocardial Left Ventricular Torsion Correlates With CMR Tagging–Derived Torsion in the Same Subjects
Authors: Gabrielle M. Colvert, Juan E. Ortuño, W. Patricia Bandettini, Marcus Y. Chen, María J. Ledesma-Carbayo, Elliot R. McVeigh
Journal: JACC. Cardiovascular imaging (2020)
Abstract 12724: The Long Non-coding RNA MALAT1 is Required for Cardiomyocytes Proliferation and Postnatal Cardiac Regeneration
Authors: Galip S Aslan, Yosif Manavski, Christina Ott, Stefanie Dimmeler
Journal: Circulation (2019)

Introduction: The adult mammalian heart has a limited capacity for regeneration and repair. Instead, fibrotic tissue replaces scarred myocardium. However, there is a short time during postnatal dev...
68Ga–Prostate-Specific Membrane Antigen-11–Avid Cardiac Metastases in a Patient With Adenoid Cystic Carcinoma, A Rare Presentation of a Rare Cancer
Authors: Maike José Maria Uijen, Wim van Boxtel, Carla Marie Louise van Herpen, Martin Gotthardt, James Nagarajah
Journal: Clinical Nuclear Medicine (2020)

Abstract Adenoid cystic carcinoma is a rare cancer that arises from secretory glands. Metastases are mainly seen in the lungs and bones. Cardiac metastases are extremely rare; only 1 case has previously been described. In this patient, cardiac metastases were suspected based on CT imaging. Tumor imaging by 68 Ga–prostate-specific membrane antigen (PSMA)-11 PET is mainly used in prostate cancer patients but is also of interest in adenoid cystic carcinoma patients because of high PSMA-ligand uptake in salivary glands. 68 Ga-PSMA-11 PET imaging supported the suspicion of cardiac metastases, because the cardiac lesions showed similar tracer uptake compared with other metastases.
Macular Atrophy Incidence and Progression in Eyes with Neovascular Age-Related Macular Degeneration Treated with Vascular Endothelial Growth Factor Inhibitors Using a Treat-and-Extend or a Pro Re Nata Regimen
Authors: Kimberly L. Spooner, Samantha Fraser-Bell, Mariano Cozzi, Giovanni Staurenghi, Alessandro Invernizzi, Davide Monteduro, Marion R. Munk, Thomas Hong, Andrew A. Chang
Journal: Ophthalmology (2020)
Alpha v beta 3 integrin and HER-2 expression profiles of the MNU induced mammary tumors in Wistar-Furth inbred Rats
Authors: Robabeh Rezaeipoor, Eric Chaney, Stephen Boppart
Journal: Cancer Research (2007)

3041  Introduction:  Tracking and ultimately destroying tumor cells is the most ambitious aim in cancer therapy. To achieve this one must be able to distinguish between normal and the cancerous cells. One of the most practical approaches is to focus on the tumor specific or associated antigens. Human epidermal growth factor receptor 2 (Her-2) also known as c-erbB-2/neu and αvβ3 integrin (Vitronectin receptor) promise to be effective targets for cancer therapy.  Materials and Method:  In this study, N-methyl-N-nitrosoureas (50 mg/kg body weight) was injected intraperitoneally twice, at a one week interval in 33 Wistar-Furth inbred female rats (32 days old). For negative control, a group of three Wistar rat were kept under the same housing conditions but with no MNU injection, receiving only the carrier buffer (0.9% NaCl, pH 4.0). Every week following the second injection, three MNU treated rats were euthanized by CO2 inhalation. Whole mount of the mammary tissues, any possible tumor, lymph nodes, etc. were dissected out and kept frozen in LN2. Five micron cryosections were made using cryostat and fixed with cold acetone for 15 minutes. For immunochemical study, mouse monoclonal anti-αv, β3, αvβ3 (Gene Tex, Inc.) and rabbit polyclonal anti-her2 (Lab Vision Neo-Markers) antibodies were used as primaries. Subsequently, FITC rabbit anti-mouse and FITC Donkey anti-rabbit were used as secondary antibodies (Jackson ImmunoResearch Laboratories). Prior to immuonostaining, all cryosections were pre-blocked using secondary isotype matched normal sera.  Results:  Different tumor sizes [from very early stage (  Conclusion:  Understanding about the expression profiles, the level, and the pathogenesis of these tumor markers will eventually lead to specific and effective cancer therapy. Having knowledge about the expression profiles of these tumor markers will help in using targeted particles for optimal imaging protocols in breast cancer.
Magnetic resonance imaging of COVID-19 anosmic patients reveals abnormalities of the olfactory bulb: Preliminary prospective study
Authors: Annaelle Chetrit, Jerome R. Lechien, Amine Ammar, Younes Chekkoury-Idrissi, Lea Distinguin, Marta Circiu, Sven Saussez, Marie-Christine Ballester, Marc Vasse, Najete Berradja, Stephane Hans, Robert Carlier, Myriam Edjlali
Journal: Journal of Infection (2020)