tbuckley/cabot-search huggingface dataset:
A DEEP LEARNING METHOD FOR DELINEATING EARLY GASTRIC CANCER RESECTION MARGIN UNDER CHROMOENDOSCOPY OR WHITE LIGHT ENDOSCOPY
Authors: P An, J Wang, L Wu, S Hu, H Yu
Journal: Endoscopy (2020)

Aims The aim of this study was to validate real-time fully convolutional networks (FCNs) to delineate the resection margin of early gastric cancer (EGC) under indigo carmine chromoendoscopy (CE) or white light endoscopy (WLE).
DIAGNOSTIC PERFORMANCE OF FRANSEEN-TIP NEEDLE EUS-FNB IN COMPARISON TO EUS-FNA IN SOLID PANCREATIC LESIONS
Authors: I Boeva, P Karagyozov, I Tishkov, K Draganov, P Dakova
Journal: Endoscopy (2020)

Aims The aim of the study is to compare the diagnostic yields of EUS FNA and EUS FNB with 22 G Franseen-tip Needle in patients with solid pancreatic masses.
Association of Medicaid Expansion Under the Patient Protection and Affordable Care Act With Non–Small Cell Lung Cancer Survival
Authors: Ying Liu, Graham A. Colditz, Benjamin D. Kozower, Aimee James, Tracy Greever-Rice, Chester Schmaltz, Min Lian
Journal: JAMA Oncology (2020)

This cohort study uses Surveillance, Epidemiology, and End Results data to assess if Medicaid expansion is associated with improved population-level survival in patients with non–small cell lung cancer.
Dr. Samuel Dodd Clippingdale
Authors: A M Cooke
Journal: BMJ (1925)

Dr Clippingdale was not directly connected with the Royal College of Physicians of London, but deserves to be remembered as an industrious and interesting medical historian.He was born in 1853, the son of a general practitioner in the East End of London.He trained in medicine at Aberdeen University and The London Hos- pital, and qualified MRCS in 1875.In the following year he obtained the Aberdeen MB, and in 1879 proceeded to the MD.In 1880 he became FRCS.He practised in Kensington, and was Surgeon to the Kensington Dis- pensary and Children's Hospital, and Police Surgeon for Kensington.Prominent in local medical affairs, he be- came President of the West London Medico-Chirurgical Society.His interests were wide
Parkin on serine: a Parkinson disease gene suppresses serine synthesis in cancer
Authors: W. Brian Dalton
Journal: Journal of Clinical Investigation (2020)

Phosphoglycerate dehydrogenase (PHGDH) catalyzes the first step in the synthesis of the amino acid serine, important for protein synthesis, one-carbon metabolism, lipid production, redox homeostasis, and other key processes of normal and cancer metabolism. While PHGDH is often overexpressed in cancer cells, how it is regulated has been unclear. In this issue of the JCI, Liu and colleagues describe a new aspect of PHGDH regulation, demonstrating that the Parkinson disease gene and tumor suppressor Parkin bound and ubiquitinated PHGDH. Parkin promoted PHGDH degradation, suppressed serine synthesis, and inhibited tumor growth in human cancer cell line xenografts. Conversely, inactivation of Parkin not only accelerated tumor growth, but also sensitized tumors to small molecule inhibitors of PHGDH. These results offer a new link between Parkin and the serine synthesis pathway, and they bear translational potential that warrants further study in Parkin-deficient human cancers.
FACTORS INFLUENCING DIAGNOSTIC ACCURACY OF ENDOSCOPIC ULTRASOUND WITH FINE NEEDLE ASPIRATION (EUS-FNA) IN PANCREATO-BILIARY TUMORS
Authors: E Troncone, C Cardamone, CM Gesuale, G Palmieri, V Formica, I Portarena, A Nardecchia, M Benassi, E Giudice, A Anselmo, L Toti, M Manzia, G Tisone, M Roselli, G Monteleone, O Paoluzi, GDV Blanco
Journal: Endoscopy (2020)

Aims To evaluate the factors influencing diagnostic accuracy of EUS-FNA in patients with suspected pancreato-biliary tumors.
THE IMPORTANCE OF INTRODUCING COLONOSCOPY SCREENING IN THE ADULT CYSTIC FIBROSIS PATIENTS: A SINGLE TERTIARY REFERRAL CENTRE ANALYSIS
Authors: J Doherty, M McCarthy, C Fleming, C Shortt, S Zulquernain, BJ Plant
Journal: Endoscopy (2020)

Aims The risk of colorectal cancer (CRC) in patients with cystic fibrosis (PWCF) is 10times greater than the general population and 30times greater post-transplant. Due to this new screening guidelines were published in Gastroenterology by the CF Colorectal Cancer Screening Task Force in 2018. Our aim in this audit is to benchmark current practise at our centre against current guidelines.
INTEROBSERVER AGREEMENT OF ENDOSCOPIC ULTRASOUND ASSESSMENT AND MANAGEMENT OF PANCREATIC FLUID COLLECTIONS (PFCS) - AN INTERNATIONAL STUDY
Authors: C Fabbri, G Gibiino, C Binda, M Sbrancia, A Anderloni, P Cecinato, A Lisotti, PG Arcidiacono, MC Petrone, I Tarantino, TH Baron, M Perez-Miranda, JB Gornals, A Larghi, P Fusaroli
Journal: Endoscopy (2020)

Aims Pancreatic and peripancreatic fluid collections (PFCs) are amongst the most ominous complications of severe acute pancreatitis and in this field Endoscopic Ultrasound (EUS) is emerging as an accurate tool for diagnostic and therapeutic approach. EUS- guided drainage is a common procedure in advanced endoscopic centres but guidelines or specific recommendation are still lacking.
Abstract 15753: Delayed Enhancement Ultrasound Imaging With Acoustically Activated Definity Droplets in Detecting and Quantifying Myocardial Infarct Size
Authors: Songita A Choudhury, Feng Xie, John Lof, Thomas R Porter
Journal: Circulation (2017)

Introduction: Commercially available Definity (Lantheus Medical) microbubbles (MB) can be converted to nanometer-sized droplets (DD) using cooled compression at the bedside. These droplets have pro...
DIAGNOSIS AND TREATMENT OF PANCREATIC DUCT DISRUPTION OR DISCONNECTION: AN INTERNATIONAL EXPERT SURVEY AND CASE VIGNETTE STUDY
Authors: HC Timmerhuis, L Boxhoorn, MG Besselink, TL Bollen, MJ Bruno, B Joseph Elmunzer, P Fockens, KD Horvath, RC Verdonk, HC van Santvoort, RP Voermans
Journal: Endoscopy (2020)

Aims A disrupted or disconnected pancreatic duct is an often overlooked and potentially severe complication of necrotizing pancreatitis. We aimed to evaluate current expert opinion regarding the diagnosis and treatment of pancreatic duct disruption and disconnection in patients with necrotizing pancreatitis to assist in developing future guidelines.
Estrogen Replacement Therapy and Risk of Ovarian Cancer in Postmenopausal Women—Reply
Authors: James V. Lacey, Jr, Pamela J. Mink, Jay H. Lubin, Mark E. Sherman, Rebecca Troisi, Patricia Hartge, Arthur Schatzkin, Catherine Schairer
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SCREENING FOR HEAD AND NECK SECOND PRIMARY TUMORS IN PATIENTS WITH ESOPHAGEAL SQUAMOUS CELL CANCER: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: SEM van de Ven, O Bugter, JA Hardillo, MJ Bruno, RJ Baatenburg de Jong, AD Koch
Journal: Endoscopy (2019)

Esophageal squamous cell carcinoma (ESCC) is often accompanied by second primary tumors in the head and neck region. Patients with an additional head and neck second primary tumor (HNSPT) have a worse prognosis than those with only ESCC. Therefore, early detection of HNSPTs may improve the overall outcome of esophageal cancer patients. The aim of this study was to review the literature to investigate the yield of endoscopic head and neck screening to detect HNSPTs in patients with ESCC. Secondary aims were to investigate whether screening should be performed synchronously or metachronously, and to investigate whether there is enough evidence to justify endoscopic screening in the Western world.
AUTOMATED POLYP SIZE ESTIMATION WITH DEEP LEARNING REDUCES OVERESTIMATION BIAS
Authors: J Suykens, T Eelbode, J Daenen, P Suetens, F Maes, R Bisschops
Journal: Endoscopy (2020)

Aims Polyp size is directly correlated with risk of future CRC and growth invasiveness. Despite its big impact, endoscopists typically provide a visual size estimation, but several studies have reported low accuracies. We aim to enable more accurate in-vivo polyp size measurements and ultimately reduce clinical mis-sizing by endoscopists. Therefore, we developed an AI system that can objectively infer polyp size based on a reference tool in the endoscopic image.
ASSESSMENT OF DIAGNOSTIC ACCURACY OF ENDOSCOPIC ULTRASOUND IN GALLBLADDER LESIONS
Authors: KR Joo, MK Chae, SY Shin
Journal: Endoscopy (2020)

Aims Endoscopic ultrasound (EUS) has been widely used in the diagnosis of gallbladder lesions. The purpose of this study was to determine whether there was a difference in diagnosis rate according to gallbladder lesions.
Complete visualization of epidermal margin during ex vivo confocal microscopy of excised tissue with 3-dimensional mosaicking and intensity projection
Authors: Mercedes Sendín-Martín, Kivanc Kose, Ucalene Harris, Anthony Rossi, Erica Lee, Kishwer Nehal, Milind Rajadhyaksha, Manu Jain
Journal: Journal of the American Academy of Dermatology (2020)
TET1 promotes growth of T-cell acute lymphoblastic leukemia and can be antagonized via PARP inhibition
Authors: Shiva Bamezai, Deniz Demir, Alex Jose Pulikkottil, Fabio Ciccarone, Elena Fischbein, Amit Sinha, Chiara Borga, Geertruy te Kronnie, Lüder-Hinrich Meyer, Fabian Mohr, Maria Götze, Paola Caiafa, Klaus-Michael Debatin, Konstanze Döhner, Hartmut Döhner, Irene González-Menéndez, Leticia Quintanilla-Fend, Tobias Herold, Irmela Jeremias, Michaela Feuring-Buske, Christian Buske, Vijay P. S. Rawat
Journal: Leukemia (2020)
Efficacy and safety of hydroxychloroquine for treatment of patients with rosacea: A multicenter, randomized, double-blind, double-dummy, pilot study
Authors: Ben Wang, Xin Yuan, Xin Huang, Yan Tang, Zhixiang Zhao, Bin Yang, Baoqi Yang, Yue Zheng, Chao Yuan, Hongfu Xie, Ji Li
Journal: Journal of the American Academy of Dermatology (2020)
LOW PREVALENCE OF COLORECTAL NEOPLASIA IN MICROSCOPIC COLITIS: A PROSPECTIVE, MULTICENTER STUDY
Authors: E Borsotti, B Barberio, R D’Incà, G Bonitta, F Cavallaro, L Pastorelli, E Rondonotti, L Samperi, M Dinelli, M Vecchi, GE Tontini
Journal: Endoscopy (2020)

Aims Microscopic colitis (MC) is the most frequent condition in subjects undergoing ileocolonoscopy for chronic non bloody diarrhea (CNBD) in Western countries. Emerging evidences have shown a negative association between MC and colorectal cancer. We designed this prospective multicentre study to determine whether the risk of colorectal neoplasia differs significantly between MC and non-MC patients receiving for the first time ever colonoscopy with high-definition and dye-less chromoendoscopy for chronic non bloody diarrhea (CNBD) of unknown origin
Telomere Length Predicts Post-Operative Atrial Fibrillation in Patients Undergoing CABG Independently of Chronological Age
Authors: M Margaritis, S Patel, A S Antonopoulos, L Herdman, M Petrou, R Sayeed, G Krasopoulos, K M Channon, B Casadei, C Antoniades
Journal: Circulation (2014)
TBX4 syndrome: a systemic disease highlighted by pulmonary arterial hypertension in its most severe form
Authors: Eric D. Austin, C. Gregory Elliott
Journal: European Respiratory Journal (2020)

<b>Thoré and co-workers add to our understanding of TBX4-associated pulmonary vascular disease as a precapillary form of pulmonary hypertension (PH), showing that TBX4 mutations may also cause multisystem anomalies concurrent with, or independent of, PH</b>https://bit.ly/2yIqb9v
Genomic Mismatch at <i>LIMS1</i> Locus and Kidney Allograft Rejection
Authors: Roman Reindl-Schwaighofer, Andreas Heinzel, Rainer Oberbauer
Journal: New England Journal of Medicine (2019)

To the Editor: Steers et al. (May 16 issue) 1 describe the association between donor-recipient genomic collision at the LIMS1 locus and the risk of kidney allograft rejection, which is mainly T-cell mediated.In addition, anti-LIMS1 antibodies were detected in patients with allograft rejection who had homozygous deletions.In vitro, these antibodies are cytotoxic.This mechanism is similar to how mismatching of human leukocyte antigen (HLA) can elicit a cellular immune response and the formation of de novo donor-specific HLA antibodies that can target mismatched HLA molecules on allograft endothelial cells. 2 In such cases, this process leads to microcirculation inflammation, the histologic hallmark of antibody-mediated rejection.However, there is a potential pathogenic difference between anti-LIMS1 and anti-HLA antibodies.In normoxic conditions, intrarenal LIMS1 expression occurs mainly in tubular epithelial cells.However, without LIMS1 expression on the surface of vascular endothelial cells, circulating anti-LIMS1 antibodies could remain harmless.Microcirculatory inflammation is often encountered without the presence of detectable donor-specific anti-HLA antibodies and may be explained by the action of non-HLA antibodies. 3,4Can the authors elaborate on whether patients with anti-LIMS1 antibodies had such inflammation?Without such an association, screening for anti-LIMS1 antibodies in patients with unexplained microcirculatory inflammation seems less relevant.
Sixty seconds on . . . following the science
Authors: Gareth Iacobucci
Journal: BMJ (2020)

Evidence based policy does feel rather important during a pandemic. But government ministers’ recent parroting of the phrase “we’re following the science” has raised some concerns.

True. But there’s a growing feeling that the mantra is being used by ministers to deflect scrutiny of their handling of the covid-19 pandemic, rather than as a meaningful explanation of policy making.

That’s the nub. At a Science …
HEPATICO-JEJUNOSTOMY´S ANASTOMOTIC STRICTURE TREATED BY ENTERAL-ENTERAL ENDOSCOPIC BYPASS GUIDED ERC: A TERTIARY REFERRAL SINGLE CENTER EXPERIENCE
Authors: M Mutignani, A Giannetti, E Forti, F Pugliese, M Cintolo, A Italia, G Bonato, R Rosa, L Dioscoridi
Journal: Endoscopy (2020)

Aims Since re-do surgery and interventional radiology are considered the first-line treatment for bilio-digestive anastomotic stricture, endoscopic treatment has been utilized as a minimally invasive alternative, with two critical issues: (1) ability to reach the biliary anastomosis; (2) perform an effective therapeutic procedure. We proposed a totally endoscopic approach to improve the endotherapy of bilio-digestive anastomotic stricture.
SAFFETY OF POLYPECTOMY IN PATIENTS WITH PEUTZ-JEGHERS SYNDROME: EXPERIENCE IN A TERTIARY CENTER
Authors: LE Zamora-Nava, M Quintanar-Martínez, G Grajales-Figueroa, R Barreto-Zúñiga, F Valdovinos-Andraca
Journal: Endoscopy (2020)

Methods We conducted a retrospective and observational study in a tertiary care center in Mexico City from 2000 to 2019. All patients with PJS diagnosis who underwent for endoscopic polypectomy were included. Their clinical characteristics, polyp size, endoscopic treatment and complications were reviewed.
Effect of Surgery vs Functional Bracing on Functional Outcome Among Patients With Closed Displaced Humeral Shaft Fractures
Authors: Lasse Rämö, Bakir O. Sumrein, Vesa Lepola, Tuomas Lähdeoja, Jonas Ranstam, Mika Paavola, Teppo Järvinen, Simo Taimela
Journal: JAMA (2020)

<h3>Importance</h3> Humeral shaft fractures traditionally have been treated nonsurgically, but there has been a steady increase in the rate of surgery over the past 2 decades without high-quality evidence to justify the trend. <h3>Objective</h3> To compare the effectiveness of surgical treatment with open reduction and internal plate fixation to nonsurgical treatment with functional bracing in the treatment of closed humeral shaft fractures. <h3>Design, Setting, and Participants</h3> Randomized clinical trial conducted at 2 university hospital trauma centers in Finland, enrollment between November 2012 and January 2018 with a final follow-up of January 2019. A total of 82 adult patients with closed, unilateral, displaced humeral shaft fracture met criteria for inclusion. Patients were excluded if they had cognitive disabilities preventing them from following the protocol or had multimorbidity or multiple trauma. <h3>Interventions</h3> Patients were randomly assigned to surgical treatment with open reduction and internal plate fixation (n = 38) or to nonsurgical treatment with functional bracing (n = 44). <h3>Main Outcome and Measure</h3> The primary outcome was Disabilities of Arm, Shoulder and Hand (DASH) score at 12 months (range, 0 to 100 points, 0 denotes no disability and 100 extreme disability; minimal clinically important difference, 10 points). <h3>Results</h3> Among 82 patients who were randomized (mean age, 48.9 years; 38 women [46%]; 44 men [54%]), 78 (95%) completed the trial. Thirteen (30%) of the patients assigned to functional bracing underwent surgery during the 12-month follow-up period to promote healing of the fracture. At 12 months, the mean DASH score was 8.9 (95% CI, 4.2 to 13.6) in the surgery group and 12.0 (95% CI, 7.7 to 16.4) in the bracing group (between-group difference, −3.1 points; 95% CI, −9.6 to 3.3;<i>P</i> = .34). Eleven patients (25%) allocated to functional bracing developed fracture nonunion. Three patients (8%) allocated to surgery developed a temporary radial nerve palsy. <h3>Conclusions and Relevance</h3> Among patients with closed humeral shaft fracture, internal fixation surgery, compared with nonoperative functional bracing, did not significantly improve functional outcomes at 12 months. However, the substantial amount of treatment crossover from nonoperative to surgical treatment should be considered when interpreting the trial results. <h3>Trial Registration</h3> ClinicalTrials.gov Identifier:NCT01719887
UNUSUAL FINDING IN A PATIENT WITH GASTROINTESTINAL OBSTRUCTION
Authors: B Ungureanu, S Iordache, A Ionescu-Ciocalteu, A Saftoiu
Journal: Endoscopy (2020)

An eighteen years old boy, presented in the Emergency Department with clinical signs of subboclusive syndrome. Patient’s history revealed that he was known with frequent episodes of abdominal pain and diarrhea. Biochemical tests showed a Hb of 9.8 g/dl and a prothrombin index of 25%. Plain abdominal radiography pointed out mixed images with horizontal levels arranged within the right flank. Colonoscopy revealed large amount of stones within the ascending colon and cecum. Lithophagia was considered as secondary to a celiac disease. Specific antibodies turned out to be positive and the diagnosis of celiac disease was confirmed by duodenal biopsies.
Monoclonal antibodies that target the hepatitis C virus envelope proteins prevent in vivo infection of an escape variant isolated from a liver transplant patient
Authors: S Fafi-Kremer, I Desombere, A Farhoudi, F Van Houtte, L Verhoye, S Beattie, J A McKeating, G Leroux-Roels, T F Baumert, A H Patel, P Meuleman
Journal: Hepatology (2012)
Outcome and Late Complications of Hepatoblastomas Treated Using the Japanese Study Group for Pediatric Liver Tumor 2 Protocol
Authors: Eiso Hiyama, Tomoro Hishiki, Kenichiro Watanabe, Kohmei Ida, Yuka Ueda, Sho Kurihara, Michihiro Yano, Ken Hoshino, Akiko Yokoi, Yuichi Takama, Yuki Nogami, Tomoaki Taguchi, Makiko Mori, Kentaro Kihira, Osamu Miyazaki, Hiroshi Fuji, Shohei Honda, Tomoko Iehara, Takuro Kazama, Junya Fujimura, Yukichi Tanaka, Takeshi Inoue, Tatsuro Tajiri, Satoshi Kondo, Takaharu Oue, Kenichi Yoshimura
Journal: Journal of Clinical Oncology (2020)

We report here the outcomes and late effects of the Japanese Study Group for Pediatric Liver Tumors (JPLT)-2 protocol, on the basis of cisplatin-tetrahydropyranyl-adriamycin (CITA) with risk stratification according to the pretreatment extent of disease (PRETEXT) classification for hepatoblastoma (HB).From 1999 to 2012, 361 patients with untreated HB were enrolled. PRETEXT I/II patients were treated with up-front resection, followed by low-dose CITA (stratum 1) or received low-dose CITA, followed by surgery and postoperative chemotherapy (stratum 2). In the remaining patients, after 2 cycles of CITA, responders received the CITA regimen before resection (stratum 3), and nonresponders were switched to ifosfamide, pirarubicin, etoposide, and carboplatin (ITEC; stratum 4). Intensified chemotherapeutic regimens with autologous hematopoietic stem-cell transplantation (SCT) after resection were an optional treatment for patients with refractory/metastatic disease.The 5-year event-free and overall survival rates of HB patients were 74.2% and 89.9%, respectively, for stratum 1, 84.8% and 90.8%%, respectively, for stratum 2, 71.6% and 85.9%%, respectively, for stratum 3, and 59.1% and 67.3%%, respectively, for stratum 4. The outcomes for CITA responders were significantly better than those for nonresponders, whose outcomes remained poor despite salvage therapy with a second-line ITEC regimen or SCT. The late effects, ototoxicity, cardiotoxicity, and delayed growth, occurred in 61, 18, and 47 patients, respectively. Thirteen secondary malignant neoplasms (SMNs), including 10 leukemia, occurred, correlating with higher exposure to pirarubicin and younger age at diagnosis.The JPLT-2 protocol achieved up-front resectability in PRETEXT I/II patients with no annotation factors, and satisfactory survival in patients who were CITA responders in the remaining patients. However, outcomes for CITA nonresponders were unsatisfactory, despite therapy intensification with ITEC regimens and SCT. JPLT-2 had a relatively low incidence of cardiotoxicity but high rates of SMNs.
HEPATIC SUBCAPSULAR HEMATOMA AFTER ERCP: AN UNCOMMON BUT POTENTIALLY VERY SERIOUS COMPLICATION
Authors: P Florez-Diez, V Jimenez-Beltran, N Rodriguez-Ferreiro, A Nieto-Jara, A Suarez-Noya, C Del Caño-Cerdan, L Carballo-Folgoso, M Celada-Sendino, A Gejo-Beneitez, M Fraile-Lopez
Journal: Endoscopy (2020)

Hepatic hematoma is an uncommon complication of ERCP, a potentially serious condition that requires specific treatment (surgery, embolization). A 37-year-old woman with choledocholithiasis underwent an ERCP with sphincterotomy and stone extraction, without incidents. 3 hours later she presented epigastric pain and anemization of 4 g of Hb. An urgent CT scan showed a left hepatic subcapsular hematoma of 14 × 6 cm, which compressed the hepatic surface, with gas bubbles in its deep portion, with no clear signs of active bleeding. Arteriography was decided without clear contrast extravasation points and empirical embolization was performed with Espongostan with good angiographic results, being discharged few days later.