tbuckley/cabot-search huggingface dataset:
Influence of Paroxysmal Nocturnal Hemoglobinuria Clone Positivity on Outcome of Childhood Acquried Aplastic Anemia: A Multicenter Center Study
Authors: Sule Unal Cangul, Deniz Yilmaz Karapinar, Arzu Yazal Erdem, Husniye Nese Yarali, Hamiyet Hekimci Ozdemir, Fatma Gumruk, Hasan Fatih Cakmakli, Elif Unal Ince, Gul Nihal Nihal Ozdemir, Muge Gokce, Tiraje Celkan, Aysenur Bahadir, Turan Bayhan, Hale Oren, Huseyin Gulen, Funda Tayfun Kupesiz, Mualla Cetin, Namik Ozbek
Journal: Blood (2018)
TCT-447 MitraClip Compared With Surgical Mitral Valve Repair in Octogenarians: A Nationwide Analysis 2012 to 2015
Authors: Aaqib Malik, Syed Zaid, Srikanth Yandrapalli, Suchith Shetty, Senada Malik, Wilbert Aronow, Cenap Undemir, Hasan Ahmad, Gilbert Tang
Journal: Journal of the American College of Cardiology (2019)
Fibrogenic fibroblast-selective near-infrared phototherapy to control scarring
Authors: Zelin Chen, Ziwen Wang, Taotao Jin, Gufang Shen, Yu Wang, Xu Tan, Yibo Gan, Fan Yang, Yunsheng Liu, Chunji Huang, Yixin Zhang, Xiaobing Fu, Chunmeng Shi
Journal: Theranostics (2019)

Rationale: Fibroblasts, the predominant cell type responsible for tissue fibrosis, are heterogeneous, and the targeting of unique fibrogenic population of fibroblasts is highly expected. Very recently, elevated glycolysis is demonstrated to play a pivotal role in the determination of fibrogenic phenotype of fibroblasts. However, it is lack of specific strategies for targeting and elimination of such fibrogenic populations. In this study, a novel strategy to use the a near-infrared (NIR) dye IR-780 for the targeting and elimination of a fibrogenic population of glycolytic fibroblasts to control the cutaneous scarring is developed. Methods: The identification and cell properties test of fibrogenic fibroblasts with IR-780 were conducted by using fluorescence activated cell sorting, transplantation experiments, in vivo imaging, RNA sequencing in human cell experiments and mouse and rat wound models. The uptake of IR-780 in fibroblasts mediated by HIF-1α/SLCO2A1 and the metabolic properties of IR-780H fibroblasts were investigated using RNA interference or signaling inhibitors. The fibrogenic fibroblast-selective near-infrared phototherapy of IR-780 were evaluated in human cell experiments and mouse wound models. Results: IR-780 is demonstrated to recognize a unique glycolytic fibroblast lineage, which is responsible for the bulk of connective tissue deposition during cutaneous wound healing and cancer stroma formation. Further results identified that SLCO2A1 is involved in the preferential uptake of IR-780 in fibrogenic fibroblasts, which is regulated by HIF-1α. Moreover, with intrinsic dual phototherapeutic activities, IR-780 significantly diminishes cutaneous scarring through the targeted ablation of the fibrogenic population by photothermal and photodynamic effects. Conclusion: This work provides a unique strategy for the targeted control of tissue scarring by fibrogenic fibroblast-selective near-infrared phototherapy. It is proposed that IR-780 based theranostic methodology holds promise for translational medicine aimed at regulation of fibrogenic behavior.
Noninvasive <i>versus</i> invasive pressure–flow relationship of the pulmonary circulation: bias and error
Authors: Sergio Caravita, Patrick Yerly, Claudia Baratto, Céline Dewachter, Andrea Faini, Asma Rimouche, Giovanna Branzi, Giovanni Battista Perego, Antoine Bondue, Gianfranco Parati, Jean-Luc Vachiéry
Journal: European Respiratory Journal (2019)

<b>Exercise echocardiography can provide imprecise but rather accurate and sensitive estimates of pressure–flow relationships of the pulmonary circulation, as compared with RHC under exercise</b>http://bit.ly/2YQIPZ1
The influence of alexithymia and mood on eating psychopathology in a non-clinical female sample
Authors: N. Ridout, D.J. Wallis, Y. Autwal, A. Kralj, J. Sellis, E. Taylor
Journal: Psychotherapy and Psychosomatics (2013)

It has been demonstrated that clinical and subclinical disor- dered eating are associated with elevated levels of depression and the personality trait alexithymia (ALX). ALX means literally lack of words for emotion and is associated with a difficulty identifying and describing feelings, and with an externally oriented cognitive style. The aim of the current study was to examine the inter-relationships between mood and ALX in accounting for variations in non-clinical eating psychopathology. 124 females were assessed on the 20- item Toronto Alexithymia Scale (TAS-20), the Hospital Anxiety and Depression Scale (HADS) and the Eating Disorders Inventory (EDI). Results revealed that EDI scores were positively associated with scores on the TAS-20 and with scores on the depression and anxi- ety subscales of the HADS. A series of stepwise multiple regressions revealed that depression and ALX accounted for 53% of the variance in total EDI scores and 40% of the variance in scores on the drive- for-thinness subscale of the EDI. Scores on the bulimia and body dissatisfaction subscales were predicted by the mood scores only. In conclusion, ALX and mood may contribute, alone and in combi- nation, to the development of some forms of disordered eating.
TCT-494 PFT-Based Antiplatelet Therapy Reduces Cardiovascular Events in Post-AMI Patients With Left Ventricular Dysfunction After Percutaneous Coronary Intervention
Authors: You Jieyun, Yuying Gu, Wei Guo, Yunli Shen, Jiming Li, Liming Gao, Yunkai Wang, Liang Geng, Xingxu Wang, Qi Zhang
Journal: Journal of the American College of Cardiology (2019)
Rammya Mathew: Improving referrals isn’t about rationing care
Authors: Rammya Mathew
Journal: BMJ (2019)

Frequently, a patient’s opening gambit in a consultation is a request for a hospital referral. More often than not this turns out to be entirely appropriate, but occasionally I recommend an alternative course of action. My general impression is that patients don’t mind this, as long as I’ve explained my rationale.

A handful of times, however, patients have asked whether my motive is to save money. I find this deeply upsetting—especially when the insinuation is that I stand to gain personally by declining their request.

However, I’m not surprised by such accusations when the …
An 80-year-old man with caecal ulceration
Authors: Benjamin Easton White, Adnan Al-Badri, John Nicholas Gordon
Journal: Gut (2019)

An 80-year-old man presented with a 3-month history of altered bowel habit, intermittent right iliac fossa abdominal discomfort and fluctuating perianal pain. He had a background of ischaemic heart disease and was taking atorvastatin, clopidogrel, bisoprolol, isosorbide mononitrate, fenofibrate, nicorandil and furosemide. Abdominal examination was unremarkable with rectal examination revealing a minor posterior fissure. He had a normochromic, normocytic anaemia of 108 g/L and a C-reactive protein of 5. Other bloods were normal.

A colonoscopy was arranged, which revealed a large area of deep ulceration in the ascending colon extending to the …
TCT-61 1-Year Outcome of Subintimal Versus Intraluminal Approach, Subintimal Versus Intraluminal Wire Passage Based on Intravascular Ultrasound Findings for Femoro-Popliteal Chronic Total Occlusions
Authors: Yusuke Tomoi, Yoshimitsu Soga, Osamu Iida, Mitsuyoshi Takahara, Kenji Ando
Journal: Journal of the American College of Cardiology (2019)
TCT-842 Long-Term Incidence of Myocardial Infarction in Patients Undergoing Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting for Isolated Left Anterior Descending Artery Disease: A Meta-Analysis
Authors: Megha Prasad, Shmuel Chen, Erin Flattery, Matthew Finn, Dimitrios Karmpaliotis, Ajay Jayant Kirtane, Jeffrey W. Moses
Journal: Journal of the American College of Cardiology (2019)
TCT-114 Comparative Data on Left Atrial Appendage Occlusion Efficacy and Clinical Outcomes by Age Group in the Amplatzer Amulet Observational Study
Authors: Xavier Freixa, Boris Schmidt, Patrizio Mazzone, Sergio Berti, Sven Fischer, Juha Lund, Matteo Montorfano, Paolo Della Bella, Simon Lam, Ignacio Cruz-Gonzalez, Heyder Omran, Giuseppe Tarantini, Adel Aminian, Jens Erik Nielsen-Kudsk
Journal: Journal of the American College of Cardiology (2019)
TCT-112 Comparison Between the Diagnostic Performance of Quantitative Flow Ratio and Myocardial Perfusion Imaging for Detecting Myocardial Ischemia
Authors: Pepijn van Diemen, Roel Driessen, Wynand Stuijfzand, Stefan Schumacher, Michiel Bom, Henk Everaars, Peter van de Ven, Jonathon Leipsic, Juhani Knuuti, Stephen Underwood, Albert van Rossum, Ibrahim Danad, Paul Knaapen
Journal: Journal of the American College of Cardiology (2019)
TCT-424 Systematic Review and Pooled Analysis of New- Versus Old-Generation Valves for Transcatheter Aortic Valve Replacement in Bicuspid Aortic Stenosis
Authors: Nausharwan Butt, Jaffar Khan, Toby Rogers, Paul Kolm, Anees Mussalam, James Edelman, Nauman Khalid, Evan Shlofmitz, Yuefeng Chen, Micaela Iantorno, Deepakraj Gajanana, Rebecca Torguson, William Weintraub, Ron Waksman
Journal: Journal of the American College of Cardiology (2019)
TCT-675 Direct Stenting Versus Adjunctive Balloon Angioplasty for Saphenous Vein Graft Percutaneous Coronary Intervention
Authors: Faisal Latif, Lauren Uyeda, Robert Edson, David Holmes, Sunil Rao, Kul Aggarwal, Barry Uretsky, Khaled Ziada, Edward McFalls, Anand Irimpen, Huu Tam Truong, Scott Kinlay, Vasilios Papademetriou, Raghava Velagaleti, Bavana Rangan, Kreton Mavromatis, Subhash Banerjee, Emmanouil Brilakis
Journal: Journal of the American College of Cardiology (2019)
De-adoption of Routine Urine Culture Testing—A Call to Action
Authors: Jerome A. Leis, Christine Soong
Journal: JAMA Internal Medicine (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
State of deworming coverage and equity in low-income and middle-income countries using household health surveys: a spatiotemporal cross-sectional study
Authors: Nathan C Lo, Sam Heft-Neal, Jean T Coulibaly, Leslie Leonard, Eran Bendavid, David G Addiss
Journal: The Lancet Global Health (2019)

Mass deworming against soil-transmitted helminthiasis, which affects 1 billion of the poorest people globally, is one of the largest public health programmes for neglected tropical diseases, and is intended to be equitable. However, the extent to which treatment programmes for deworming achieve equitable coverage across wealth class and sex is unclear and the public health metric of national deworming coverage does not include representation of equity. This study aims to measure both coverage and equity in global, national, and subnational deworming to guide future programmatic evaluation, investment, and metric design.We used nationally representative, geospatial, household data from Demographic and Health Surveys that measured mother-reported deworming in children of preschool age (12-59 months). Deworming was defined as children having received drugs for intestinal parasites in the previous 6 months before the survey. We estimated deworming coverage disaggregated by geography, wealth quintile, and sex, and computed an equity index. We examined trends in coverage and equity index across countries, within countries, and over time. We used a regression model to compute the household correlates of deworming and ecological correlates of equitable deworming.Our study included 820 883 children living in 50 countries from Africa, the Americas, Asia, and Europe that are endemic for soil-transmitted helminthiasis using 77 Demographic and Health Surveys from December, 2003, to October, 2017. In these countries, the mean deworming coverage in preschool children was estimated at 33·0% (95% CI 32·9-33·1). The subnational coverage ranged from 0·5% to 87·5%, and within-country variation was greater than between-country variation. Of the 31 countries reporting that they reached the WHO goal of more than 75% national coverage, 30 had inequity in deworming, with treatment concentrated in wealthier populations. We did not detect systematic differences in deworming equity by sex.Substantial inequities in mass deworming programmes are common as wealthier populations have consistently higher coverage than that of the poor, including in countries reporting to have reached the WHO goal of more than 75% national coverage. These inequities seem to be geographically heterogeneous, modestly improving over time, with no evidence of sex differences in inequity. Future reporting of deworming coverage should consider disaggregation by geography, wealth, and sex with incorporation of an equity index to complement the conventional public health metric of national deworming coverage.Bill & Melinda Gates Foundation, Stanford University Medical Scientist Training Program.
TCT-561 The Lesion and Procedure Characteristics Associated With “Easy-to-Recanalize” for Chronic Total Occlusion of the Superficial Femoral Artery in Endovascular Treatment
Authors: Yutaka Tadano, Jun-ichi Kotani, Takuya Haraguchi, Tomohiko Watanabe, Takuro Sugie, Daitaro Kanno, Yoshifumi Kashima, Tsutomu Fujita
Journal: Journal of the American College of Cardiology (2019)
Diet Associations With Nonalcoholic Fatty Liver Disease in an Ethnically Diverse Population: The Multiethnic Cohort
Authors: Mazen Noureddin, Shira Zelber‐Sagi, Lynne R. Wilkens, Jacqueline Porcel, Carol J. Boushey, Loïc Le Marchand, Hugo R. Rosen, Veronica Wendy Setiawan
Journal: Hepatology (2019)

Background and Aims Epidemiological data on dietary risk factors for nonalcoholic fatty liver disease (NAFLD) from population‐based studies, particularly in an ethnically diverse population, are scarce. We examined dietary factors in relation to NAFLD risk in African Americans, Japanese Americans, Latinos, native Hawaiians, and whites in the Multiethnic Cohort (MEC). Approach and Results A nested case–control analysis was conducted within the MEC, a large prospective study with &gt;215,000 older adult participants in Hawaii and California. NAFLD was identified using Medicare claims data, and controls were selected among participants without liver disease and individually matched to cases by birth year, sex, ethnicity, and length of Medicare enrollment. Diet was assessed at baseline through a validated quantitative food frequency questionnaire. Diet–NAFLD associations were quantified by odds ratios and 95% confidence intervals using multivariable conditional logistic regression. The study consisted of 2,974 NAFLD cases (518 with cirrhosis, 2,456 without cirrhosis) and 29,474 matched controls. Red meat ( P trend = 0.010), processed red meat ( P trend = 0.004), poultry ( P trend = 0.005), and cholesterol ( P trend = 0.005) intakes were positively associated with NAFLD, while dietary fiber intake ( P trend = 0.003) was inversely associated with risk. Stronger associations were observed between red meat and cholesterol and NAFLD with cirrhosis than without cirrhosis ( P heterogeneity ≤0.014). Conclusions Dietary factors are independently associated with NAFLD and NAFLD‐related cirrhosis in a multiethnic population. Decreasing the consumption of cholesterol, red and processed meat, and poultry and increasing consumption of fiber may reduce the risk for NAFLD and related advanced liver disease.
TCT-217 Predictors for Long-Term Target Lesion Revascularization of Successful Recanalized Coronary Chronic Total Occlusion Using Drug-Eluting Stents
Authors: Lei Song, Changdong Guan, Zhongwei Sun, Tongqiang Zou, Lihua Xie, Yue Jin Yang, Bo Xu
Journal: Journal of the American College of Cardiology (2019)
TCT-278 Clinical Outcomes of All-Comer Patients Presenting With Acute Coronary Syndrome Treated With the COMBO Stent: From the MASCOT and REMEDEE Registry
Authors: Vera de Winter, Doreen Zeebregts, Puk de Wilde, Jaya Chandrasekhar, Deborah Kalkman, Melissa Aquino, Pier Woudstra, Marcel Beijk, Davide Cao, Ridhima Goel, Rishi Chandiramani, Moritz Blum, Anastasios Roumeliotis, Rachel Singleton, Samantha Sartori, Usman Baber, Jan Tijssen, Karel Koch, George Dangas, Antonio Colombo, Robbert de Winter, Roxana Mehran
Journal: Journal of the American College of Cardiology (2019)
Peter Lance d’Ambrumenil
Authors: John Cherry
Journal: BMJ (2019)

Peter Lance d’Ambrumenil was educated at All Hallows School in Shepton Mallett and the Oratory School in Reading. He studied chemistry at Reading University for a year before gaining admission to St Bartholomew’s Hospital Medical College in 1970 to follow his true vocation. He graduated in 1975 and entered general practice in 1978 in Odiham, Hampshire. Afterwards he moved to Old Basing to establish a new practice, initially on a singlehanded basis, which is large and flourishing today.

After eight years as a principal he became frustrated by the constraints of …
TCT-277 Global Differences in Predictors of Long-Term Outcomes After Percutaneous Coronary Intervention: Insights From the XIENCE Pooled Registry
Authors: Rishi Chandiramani, Moritz Blum, Davide Cao, Anastasios Roumeliotis, Ridhima Goel, Lijuan Jenny Wang, Marco Valgimigli, Roxana Mehran
Journal: Journal of the American College of Cardiology (2019)
TCT-147 Stress Aortic Valve Index (SAVI) With Dobutamine for Low-Gradient Aortic Stenosis
Authors: Jo Zelis, Pim Tonino, Daniel Johnson, Prakash Balan, Guus Brueren, Inge Wijnbergen, Richard Kirkeeide, Nico Pijls, K. Lance Gould, Nils Johnson
Journal: Journal of the American College of Cardiology (2019)
TCT-486 Critical Role of Stakeholders in STEMI Networks
Authors: Sameer Mehta, Roberto Botelho, Jamil Cade, Marco Perin, Mauricio Prudente, Ricardo Cavalcanti, Cesar Dusilek, Rodolfo Cardoso, Nabil Hamdan, Luis Ignacio Calderon, Juan Carlos Perez Alva, Alfredo Estrada, Manuel De Los Rios Ibarra, Alejandro Ricalde, Alejandra Frauenfelder, Daniel Vieira, Mariana Ceschim, Genesis Del Nogal, Pedro Cruz, Benjamin Wood, Akhil Vaid
Journal: Journal of the American College of Cardiology (2019)
TCT-292 5-Years’ Comparison of Vessel Remodeling Between a Thin-Strut Non–Drug-Eluting Bioresorbable Stent and Bare-Metal Stent in Porcine Coronary Arteries
Authors: Marco Ferrone, Yanping Cheng, Gerard Conditt, Jenn McGregor, Grzegorz Kaluza, Juan Granada
Journal: Journal of the American College of Cardiology (2019)
Case 30-2019: A 65-Year-Old Woman with Lung Cancer and Chest Pain
Authors: Timothy E. Guiney, Mathew S. Lopes, Mannudeep K. Kalra, Meghan J. Mooradian, Tomas G. Neilan, James R. Stone
Journal: New England Journal of Medicine (2019)

A 65-year-old woman presented to the hospital with chest pain and dyspnea. Three weeks earlier, treatment with nivolumab had been initiated for metastatic KRAS-positive lung adenocarcinoma. The troponin T level, d-dimer level, and white-cell count were elevated. Diagnostic tests were performed.
Improvements to the US Preventive Services Task Force Recommendation Statement
Authors: John W. Epling, Amanda E. Borsky, Jessie Gerteis
Journal: JAMA (2019)

US Preventive Services Task Force; Douglas K. Owens, MD, MS; Karina W. Davidson, PhD, MASc; Alex H. Krist, MD, MPH; Michael J. Barry, MD; Michael Cabana, MD, MA, MPH; Aaron B. Caughey, MD, PhD; Chyke A. Doubeni, MD, MPH; John W. Epling Jr, MD, MSEd; Martha Kubik, PhD, RN; C. Seth Landefeld, MD; Carol M. Mangione, MD, MSPH; Lori Pbert, PhD; Michael Silverstein, MD, MPH; Melissa A. Simon, MD, MPH; Chien-Wen Tseng, MD, MPH, MSEE; John B. Wong, MD
Analysis of response pattern for patients with recurrent or metastatic colorectal cancer treated with Irinotecan, 5-FU, and low dose leucovorin (modified FOLFIRI) as 1st line chemotherapy
Authors: M. A. Lee, J. H. Kang, Y. S. Hong, K. S. Lee, S. M. Park, W. K. Kang, S. M. Park
Journal: Journal of Clinical Oncology (2006)

13546 Background: Irinotecan in combination with 5-fluorouracil (5-FU) and high dose leucovorin (LV), known as FOLFIRI regimen, has shown activity in recurrent or metastatic colorectal cancer. We analyzed the response pattern of irinotecan, 5-FU and low dose LV (modified FOLFIRI) as a first line therapy for patients with relapsed or metastatic colorectal cancer. Methods: Between September 2002 and November 2005, 46 patients with histologically confirmed recurrent or metastatic colorectal cancer were enrolled. The chemotherapy schedule consisted of irinotecan 180 mg/m 2 intravenous (i.v) on day 1, 5-FU 400 mg/m 2 as i.v bolus with 600 mg/m 2 as a 22hr continuous infusion on day 1 and 2, leucovorin 20 mg/m 2 on day 1 and 2, repeated every two weeks.We investigated the pattern of response to chemotherapy according to clinical parameters. Results: The overall response rate was 47.8%. There was no difference according to disease status and location of primary cancer, but Each metastatic lesions showed different response to chemotherapy. The response rate for metastatic lesions in liver was 54.2%, but only 7.7% for lung lesion. Most peritoneal lesions and lymphadenopathies showed stable disease (60.0% and 55.6%, respectively). 27 patients received 2 nd line chemotherapy with oxaliplatin, 5-FU and leucovorin (FOLFOX regimen) after progressive disease. The overall response rate with FOLFOX was 15.2%. With 2 nd line chemotherapy, response rate for lesions in liver was 23.5%, but 11.1% for lung lesions. For peritoneal seeding, no response was observed (72.7% stable disease). If the lesion did not achieve response to 1st line chemotherapy, it did not showed response to 2nd line treatment. Conclusions: The response to chemotherapy may be different according to metastatic site within same cancer. The lesions in liver may respond better than those in lung. If the lesion is classified ‘refractory‘ with 1st line treatment, or stage IV cancer with lung or peritoneal seeding only, we may consider more aggressive treatment to achieve better response. No significant financial relationships to disclose.