tbuckley/cabot-search huggingface dataset:
TCT-526 Impact of Pre-existing Conduction Abnormalities on Permanent Pacemaker Requirement and Survival in Patients Undergoing Transcatheter Aortic Valve Replacement With Sapien-3 Valve
Authors: Yasser Sammour, Kimi Sato, Arnav Kumar, Kinjal Banerjee, Manpreet Kaur, Jay Patel, Cameron Incognito, Hassan Lak, Mohamed Gad, Keerat Rai Ahuja, Lars Svensson, Stephanie Mick, Khaldoun Tarakji, Rishi Puri, Grant Reed, James Yun, Amar Krishnaswamy, Samir Kapadia
Journal: Journal of the American College of Cardiology (2019)
TCT-540 The Prognostic Impact of Bleeding and Ischemic Events on Mortality in Atrial Fibrillation Patients Undergoing Percutaneous Coronary Intervention: Results From a Multicenter Registry
Authors: Hisao Otsuki, Junichi Yamaguchi, Yusuke Inagaki, Suguru Ebihara, Kazuki Tanaka, Masashi Nakao, Nobuhisa Hagiwara
Journal: Journal of the American College of Cardiology (2019)
<i>MUC5B</i> variant is associated with visually and quantitatively detected preclinical pulmonary fibrosis
Authors: Susan K Mathai, Stephen Humphries, Jonathan A Kropski, Timothy S Blackwell, Julia Powers, Avram D Walts, Cheryl Markin, Julia Woodward, Jonathan H Chung, Kevin K Brown, Mark P Steele, James E Loyd, Marvin I Schwarz, Tasha Fingerlin, Ivana V Yang, David A Lynch, David A Schwartz
Journal: Thorax (2019)

Background Relatives of patients with familial interstitial pneumonia (FIP) are at increased risk for pulmonary fibrosis. We assessed the prevalence and risk factors for preclinical pulmonary fibrosis (PrePF) in first-degree relatives of patients with FIP and determined the utility of deep learning in detecting PrePF on CT. Methods First-degree relatives of patients with FIP over 40 years of age who believed themselves to be unaffected by pulmonary fibrosis underwent CT scans of the chest. Images were visually reviewed, and a deep learning algorithm was used to quantify lung fibrosis. Genotyping for common idiopathic pulmonary fibrosis risk variants in MUC5B and TERT was performed. Findings In 494 relatives of patients with FIP from 263 families of patients with FIP, the prevalence of PrePF on visual CT evaluation was 15.6% (95% CI 12.6 to 19.0). Compared with visual CT evaluation, deep learning quantitative CT analysis had 84% sensitivity (95% CI 0.72 to 0.89) and 86% sensitivity (95% CI 0.83 to 0.89) for discriminating subjects with visual PrePF diagnosis. Subjects with PrePF were older (65.9, SD 10.1 years) than subjects without fibrosis (55.8 SD 8.7 years), more likely to be male (49% vs 37%), more likely to have smoked (44% vs 27%) and more likely to have the MUC5B promoter variant rs35705950 (minor allele frequency 0.29 vs 0.21). MUC5B variant carriers had higher quantitative CT fibrosis scores (mean difference of 0.36%), a difference that remains significant when controlling for age and sex. Interpretation PrePF is common in relatives of patients with FIP. Its prevalence increases with age and the presence of a common MUC5B promoter variant. Quantitative CT analysis can detect these imaging abnormalities.
Analysis of mutation detection in cell-free DNA in ascites using comprehensive NGS panel.
Authors: Chunmei Shi, Yan Zhang, Lingjun Zhu, Pingping Dai, Yong Tang, Junping Zhang, Jie Gao, Chi Zhang, Yan-Fang Guan, Xuefeng Xia, Ling Yang, Xin Yi
Journal: Journal of Clinical Oncology (2019)

e13029 Background: Ascites is one of complications for patients with malignancies in advanced stage. Detection and characterization of cell-free DNA (cfDNA) from ascites effusions have not yet been studied. Herein, we analysis genomic alterations present in advanced cancer with ascites. Methods: We implemented targeted capture NGS with a panel of 1021 cancer-relevant genes on 85 ascites ctDNA, also on 46 matched plasma and 9 tissue from 85 patients. Results: Among 85 patients with advanced cancer, 42 digest system cancer (DC), 16 gynecologic cancer (GC), 14 non-small cell lung cancer(NSCLC) and 13 other solid tumors included. Overall, 90%(77/85) patients detected somatic mutations, which were identified predominantly in TP53 and KRAS for DC and TP53 for GC. Among NSCLC patients with ascites, nine were treated with EGFR TKI-targeted therapy previously. Mutations lead to the resistance of EGFR-TKI were identified in 55.6% (5/9) cases, including acquired EGFR T790M/C797S and primary BRAF V600E. These indicate ctDNA in ascites can used to guide tumor treatment and monitor of resistance. For the 46 pairs of ascites and plasma samples, actionable variations with on label, off-label, or experimental drugs available, were identified in 61% (n = 28) of ascites effusion samples, whereas plasma was 46% (n = 21). Median number of ascites somatic mutations was 4, while the median number was 3 in plasma samples. Of that, 85% and 61% of plasma ctDNA and ascites cfDNA samples were observed with the highest MAF above 1%. In addition, 63% and 35% of plasma ctDNA and pleural cfDNA samples were observed with the highest MAF above 10%. For the 9 groups of plasma, ascites and tumor tissue samples, at least 1 mutations within tissue was detected in 8 ascites samples and 6 in plasma samples. Conclusions: Our results suggest that cfDNA from ascites is more sensitive than plasma and had higher similarity with the tumor tissues for advanced cancer patients. With higher MAF and detection rate of actionable variations, cfDNA from ascites might provide additional information not detected with plasma cell-free DNA guide more precise cancer treatment.
Physician Aid-in-Dying and Suicide Prevention in Psychiatry: A Moral Crisis?
Authors: Brent M. Kious, Margaret (Peggy) Battin
Journal: The American Journal of Bioethics (2019)

Involuntary psychiatric commitment for suicide prevention and physician aid-in-dying (PAD) in terminal illness combine to create a moral dilemma. If PAD in terminal illness is permissible, it should also be permissible for some who suffer from nonterminal psychiatric illness: suffering provides much of the justification for PAD, and the suffering in mental illness can be as severe as in physical illness. But involuntary psychiatric commitment to prevent suicide suggests that the suffering of persons with mental illness does not justify ending their own lives, ruling out PAD. Since both practices have compelling underlying justifications, the most reasonable accommodation might seem to be to allow PAD for persons with mental illness whose suffering is severe enough to justify self-killing, but prohibit PAD for persons whose suffering is less severe. This compromise, however, would require the articulation of standards by which persons' mental as well as physical suffering could be evaluated. Doing so would present a serious philosophical challenge.
TCT-110 The Prognostic Value of Angiography-Based Vessel-FFR After Successful Percutaneous Coronary Intervention: The FAST Outcome Study
Authors: Kaneshka Masdjedi, Jurgen Ligthart, Karen Witberg, Mariusz Tomaniak, Laurens Zandvoort, Roberto Diletti, Felix Zijlstra, Nicolas Van Mieghem, Joost Daemen
Journal: Journal of the American College of Cardiology (2019)
Decreased Physical Activity in Autologous Stem Cell Recipients Leads to Reduced QOL Scores during Hospitalization
Authors: Candice Baldeo, Yenny Moreno Vanegas, Sharad Khurana, Madiha Iqbal, Abdel-Ghani Azzouqa, Taimur Sher, Sikander Ailawadhi, Prakash Vishnu
Journal: Blood (2018)
TCT-195 Anatomical Attributes of Myocardial Territory of Diagonal Branches Assessed by Coronary Computed Tomography Angiography
Authors: Seokhun Yang, Bon-Kwon Koo, Won Kyeong Jeon, Jonghanne Park, Minseok Suh, Hyung Yoon Kim, Joo Myung Lee, Kyung-Jin Kim, Jin-Ho Choi, Hong-Seok Lim, Jin Chul Paeng, Jinlong Zhang, Doyeon Hwang, Jeehoon Kang, Jung-Kyu Han, Han-Mo Yang, Kyung Woo (K.W.) Park, Hyo-Soo Kim
Journal: Journal of the American College of Cardiology (2019)
Age at Diagnosis of Type 2 Diabetes Mellitus and Associations With Cardiovascular and Mortality Risks
Authors: Naveed Sattar, Araz Rawshani, Stefan Franzén, Aidin Rawshani, Ann-Marie Svensson, Annika Rosengren, Darren K. McGuire, Björn Eliasson, Soffia Gudbjörnsdottir
Journal: Circulation (2019)

Background: Risk of cardiovascular disease (CVD) and mortality for patients with versus without type 2 diabetes mellitus (T2DM) appears to vary by the age at T2DM diagnosis, but few population studies have analyzed mortality and CVD outcomes associations across the full age range. Methods: With use of the Swedish National Diabetes Registry, everyone with T2DM registered in the Registry between 1998 and 2012 was included. Controls were randomly selected from the general population matched for age, sex, and county. The analysis cohort comprised 318 083 patients with T2DM matched with just &lt;1.6 million controls. Participants were followed from 1998 to 2013 for CVD outcomes and to 2014 for mortality. Outcomes of interest were total mortality, cardiovascular mortality, noncardiovascular mortality, coronary heart disease, acute myocardial infarction, stroke, heart failure, and atrial fibrillation. We also examined life expectancy by age at diagnosis. We conducted the primary analyses using Cox proportional hazards models in those with no previous CVD and repeated the work in the entire cohort. Results: Over a median follow-up period of 5.63 years, patients with T2DM diagnosed at ≤40 years had the highest excess risk for most outcomes relative to controls with adjusted hazard ratio (95% CI) of 2.05 (1.81–2.33) for total mortality, 2.72 (2.13–3.48) for cardiovascular-related mortality, 1.95 (1.68–2.25) for noncardiovascular mortality, 4.77 (3.86–5.89) for heart failure, and 4.33 (3.82–4.91) for coronary heart disease. All risks attenuated progressively with each increasing decade at diagnostic age; by the time T2DM was diagnosed at &gt;80 years, the adjusted hazard ratios for CVD and non-CVD mortality were &lt;1, with excess risks for other CVD outcomes substantially attenuated. Moreover, survival in those diagnosed beyond 80 was the same as controls, whereas it was more than a decade less when T2DM was diagnosed in adolescence. Finally, hazard ratios for most outcomes were numerically greater in younger women with T2DM. Conclusions: Age at diagnosis of T2DM is prognostically important for survival and cardiovascular risks, with implications for determining the timing and intensity of risk factor interventions for clinical decision making and for guideline-directed care. These observations amplify support for preventing/delaying T2DM onset in younger individuals.
Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation
Authors: Jack L. Martin, Ana S. H. Costa, Anja V. Gruszczyk, Timothy E. Beach, Fay M. Allen, Hiran A. Prag, Elizabeth C. Hinchy, Krishnaa Mahbubani, Mazin Hamed, Laura Tronci, Efterpi Nikitopoulou, Andrew M. James, Thomas Krieg, Alan J. Robinson, Margaret M. Huang, Stuart T. Caldwell, Angela Logan, Laura Pala, Richard C. Hartley, Christian Frezza, Kourosh Saeb-Parsy, Michael P. Murphy
Journal: Nature Metabolism (2019)
TCT-136 Validation of Surgical Risk Scores (EuroSCORE, EuroSCORE II, and STS) Power to Predict Mortality After TAVR
Authors: Javier Lopez-Pais, Diego Lopez Otero, Pablo Antunez Muinos, Rocío González Ferreiro, Marta Perez Poza, Fernando Gómez Peña, Alfredo Redondo Dieguez, Ana Belen Cid Alvarez, Ramiro Trillo
Journal: Journal of the American College of Cardiology (2019)
Primary prostate cancer educates bone stroma through exosomal pyruvate kinase M2 to promote bone metastasis
Authors: Jinlu Dai, June Escara-Wilke, Jill M. Keller, Younghun Jung, Russell S. Taichman, Kenneth J. Pienta, Evan T. Keller
Journal: The Journal of Experimental Medicine (2019)

Prostate cancer (PCa) metastasizes selectively to bone through unknown mechanisms. In the current study, we identified exosome-mediated transfer of pyruvate kinase M2 (PKM2) from PCa cells into bone marrow stromal cells (BMSCs) as a novel mechanism through which primary tumor-derived exosomes promote premetastatic niche formation. We found that PKM2 up-regulates BMSC CXCL12 production in a HIF-1α-dependent fashion, which subsequently enhances PCa seeding and growth in the bone marrow. Furthermore, serum-derived exosomes from patients with either primary PCa or PCa metastasis, as opposed to healthy men, reveal that increased exosome PKM2 expression is associated with metastasis, suggesting clinical relevance of exosome PKM2 in PCa. Targeting the exosome-induced CXCL12 axis diminished exosome-mediated bone metastasis. In summary, primary PCa cells educate the bone marrow to create a premetastatic niche through primary PCa exosome-mediated transfer of PKM2 into BMSCs and subsequent up-regulation of CXCL12. This novel mechanism indicates the potential for exosome PKM2 as a biomarker and suggests therapeutic targets for PCa bone metastasis.
Modification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA‐B*57:01 binding and T‐cell activation
Authors: Paul J. Thomson, Patricia T. Illing, John Farrell, Mohammad Alhaidari, Catherine C. Bell, Neil Berry, Paul M. O’Neill, Anthony W. Purcell, Kevin B. Park, Dean J. Naisbitt
Journal: Allergy (2019)

Abstract Background Abacavir is associated with hypersensitivity reactions in individuals positive for the HLA‐B*57:01 allele. The drug binds within the peptide binding groove of HLA‐B*57:01 altering peptides displayed on the cell surface. Presentation of these HLA‐abacavir‐peptide complexes to T‐cells is hypothesized to trigger a CD8 + T‐cell response underpinning the hypersensitivity. Thus, the aim of this study was to explore the relationship between the structure of abacavir with HLA‐B*57:01 binding and the CD8 + T‐cell activation. Methods Seventeen abacavir analogues were synthesized and cytokine secretion from abacavir/abacavir analogue‐responsive CD8 + T‐cell clones was measured using IFN‐γ ELIspot. In silico docking studies were undertaken to assess the predicted binding poses of the abacavir analogues within the HLA‐B*57:01 peptide binding groove. In parallel, the effect of selected abacavir analogues on the repertoire of self‐peptides presented by cellular HLA‐B*57:01 was characterized using mass spectrometry. Results Abacavir and ten analogues stimulated CD8 + T‐cell IFN‐γ release. Molecular docking of analogues that retained antiviral activity demonstrated a relationship between predicted HLA‐B*57:01 binding orientations and the ability to induce a T‐cell response. Analogues that stimulated T‐cells displayed a perturbation of the natural peptides displayed by HLA‐B*57:01. The antigen‐specific CD8 + T‐cell response was dependent on the enantiomeric form of abacavir at both cyclopropyl and cyclopentyl regions. Conclusion Alteration of the chemical constitution of abacavir generates analogues that retain a degree of pharmacological activity, but have variable ability to activate T‐cells. Modelling and immunopeptidome analysis delineate how drug HLA‐B*57:01 binding and peptide display by antigen presenting cells relate to the activation of CD8 + T‐cells.
A Treatise on Nasal Suppuration; or Suppurative Diseases of the Nose and Its Accessory Sinuses
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Government announces details of hospital building programme in England
Authors: Gareth Iacobucci
Journal: BMJ (2019)

The government has announced a £2.8bn (€3.1bn; $3.4bn) hospital building programme in England that will fund six new facilities between now and 2025.1

An additional 34 hospital rebuilds will be delivered between 2025 and 2030, subject to business case approvals, as part of a long term programme of investment.

Announcing the plans at the Conservative Party conference in Manchester on 30 September, the health and social care secretary, Matt Hancock, described the scheme as “the biggest hospital building programme in a generation.” …
Magnetic anchor-guided endoscopic submucosal dissection using a stainless steel anchor
Authors: Ippei Matsuzaki, Hiroki Yamauchi, Naoya Goto, Yuji Iwata, Mafu Tsunemi, Makoto Kobayashi, Masashi Hattori
Journal: Endoscopy (2019)

Colorectal endoscopic submucosal dissection (ESD) is technically difficult and involves long procedure times with the risk of perforation because of the thinness of the muscularis propria and the poor maneuverability of the endoscope [1] [2]. Magnetic anchor-guided (MAG) systems using neodymium magnets have been reported to be useful in resolving the difficulties of ESD [3] [4]. However, a remaining problem with this procedure has been the inability to deliver the magnetic anchor through the scope [5].
Immunoglobulin-driven Complement Activation Regulates Proinflammatory Remodeling in Pulmonary Hypertension
Authors: Maria G. Frid, B. Alexandre McKeon, Joshua M. Thurman, Bradley A. Maron, Min Li, Hui Zhang, Sushil Kumar, Timothy Sullivan, Jennifer Laskowsky, Mehdi A. Fini, Samantha Hu, Rubin M. Tuder, Aneta Gandjeva, Martin R. Wilkins, Christopher J. Rhodes, Pavandeep Ghataorhe, Jane A. Leopold, Rui-Sheng Wang, V. Michael Holers, Kurt R. Stenmark
Journal: American Journal of Respiratory and Critical Care Medicine (2019)

Rationale: Pulmonary hypertension (PH) is a life-threatening cardiopulmonary disorder in which inflammation and immunity have emerged as critical early pathogenic elements. Although proinflammatory processes in PH and pulmonary arterial hypertension (PAH) are the focus of extensive investigation, the initiating mechanisms remain elusive.Objectives: We tested whether activation of the complement cascade is critical in regulating proinflammatory and pro-proliferative processes in the initiation of experimental hypoxic PH and can serve as a prognostic biomarker of outcome in human PAH.Methods: We used immunostaining of lung tissues from experimental PH models and patients with PAH, analyses of genetic murine models lacking specific complement components or circulating immunoglobulins, cultured human pulmonary adventitial fibroblasts, and network medicine analysis of a biomarker risk panel from plasma of patients with PAH.Measurements and Main Results: Pulmonary perivascular-specific activation of the complement cascade was identified as a consistent critical determinant of PH and PAH in experimental animal models and humans. In experimental hypoxic PH, proinflammatory and pro-proliferative responses were dependent on complement (alternative pathway and component 5), and immunoglobulins, particularly IgG, were critical for activation of the complement cascade. We identified Csf2/GM-CSF as a primary complement-dependent inflammatory mediator. Furthermore, using network medicine analysis of a biomarker risk panel from plasma of patients with PAH, we demonstrated that complement signaling can serve as a prognostic factor for clinical outcome in PAH.Conclusions: This study establishes immunoglobulin-driven dysregulated complement activation as a critical pathobiological mechanism regulating proinflammatory and pro-proliferative processes in the initiation of experimental hypoxic PH and demonstrates complement signaling as a critical determinant of clinical outcome in PAH.
TCT-348 Comparison of Stent Expansion Between OCT-Guided Rotational Atherectomy and IVUS-Guided Rotational Atherectomy for Calcified Coronary Lesion
Authors: Norihiro Kobayashi, Yoshiaki Ito, Keisuke Hirano, Masahiro Yamawaki, Motoharu Araki
Journal: Journal of the American College of Cardiology (2019)
What Is Safe Household Firearm Storage to Prevent Deaths Among US Youths?
Authors: Robert S. Brown
Journal: JAMA Pediatrics (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
THE UTILITY OF SALINE-INDUCED RESTING FULL-CYCLE RATIO COMPARED WITH RESTING FULL-CYCLE RATIO ANDFRACTIONAL FLOW RESERVE
Authors: Takao Sato, Yoshifusa Aizawa, Yusuke Ohta, Sonoka Goto, Yuji Taya, Minoru Takahashi, Masaaki Okabe
Journal: Journal of the American College of Cardiology (2020)
TCT-844 Very Late (&gt;1 Year) Stent-Related Adverse Cardiovascular Events: Individual Patient Data and Network Meta-Analyses From 19 Randomized Clinical Trials
Authors: Mahesh Madhavan, Ajay Jayant Kirtane, Bjorn Redfors, John Burton, Ori Ben-Yehuda, Tullio Palmerini, Umberto Benedetto, Giuseppe Biondi-Zoccai, Pieter Smits, Clemens von Birgelen, Roxana Mehran, Thomas McAndrew, Patrick Serruys, Martin Leon, Stuart Pocock, Gregg Stone
Journal: Journal of the American College of Cardiology (2019)
Ischemia on PET MPI May Identify Patients With Improvement in Angina and Health Status Post-Revascularization
Authors: Krishna K. Patel, John A. Spertus, Suzanne V. Arnold, Paul S. Chan, Kevin F. Kennedy, Philip G. Jones, Firas Al Badarin, James A. Case, Staci Courter, A. Iain McGhie, Timothy M. Bateman
Journal: Journal of the American College of Cardiology (2019)