tbuckley/cabot-search huggingface dataset:
Acceptable Toxicity and Good Hematological and Renal Responses after Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma Patients with Renal Insufficiency at Transplant: A Prospective SFGM-TC Observational Study
Authors: Laurent Garderet, Hafida Ouldjeriouat, Mohamed-Amine Bekadja, Elisabeth Daguenet, Laure Vincent, Damien roos Weil, Marguerite Vignon, Mohamad Mohty, Julie Abraham, Martine Escoffre-Barbe, Bruno Lioure, Redhouane Ahmed Nacer, Denis Caillot, Clara Mariette, Lionel Karlin, Pierre Morel, Lila Gilis, Emanuelle Leray, Anaise Blouet, Nicole Raus, Marie Robin, jean Jacques Boffa, Pierre Ronco, Marie Thérèse Rubio, Jérôme Cornillon
Journal: Blood (2020)
High MYC Protein Expression in MDS Is Associated with Early Transformation to AML
Authors: Seongseok Yun, David Gajzer, Najla Al Ali, Nicole D. Vincelette, Pukhraz Basra, Chetasi Talati, Andrew T. Kuykendall, Eric Padron, Kendra Sweet, Rami S. Komrokji, Jeffrey E. Lancet, David A. Sallman, Ling Zhang
Journal: Blood (2020)
Is Tandem ASCT Needed in MM Patients with High Risk Cytogenetics in the Era of Maintenance Therapy? Results from the Canadian Myeloma Research Group (CMRG) Database
Authors: Peter Duggan, Donna E. Reece, Kevin Song, Victor Jimenez-Zepeda, Arleigh McCurdy, Martha L Louzada, Hira S Mian, Michael Sebag, Darrell J White, Julie Stakiw, Richard Leblanc, Esther Masih-Khan, Eshetu G Atenafu, Rami Kotb, Muhammad Aslam, Anthony Reiman, Engin Gul, Christopher P. Venner
Journal: Blood (2020)
Abstract 227: Lack of Beta-carotene 9’,10’ Diooxygenase (Bco2) Impacts Cardiac Postnatal Growth and Energy Metabolism in Female Mice
Authors: Chelsee Holloway, Youn-kyung Kim, Guo Zhong, Nina Isoherranen, Loredana Quadro
Journal: Circulation Research (2020)

As the postnatal heart grows it also undergoes critical metabolic adaptations to use mainly lipids rather than carbohydrates as energy-providing substrates. Abnormal growth patterns and lack of metabolic flexibility are pathological responses of the heart that lead to cardiovascular diseases (CVD). Carotenoids, such as β-carotene - the most abundant dietary precursor of vitamin A - have been linked to the prevention of CVD. In the heart, β-carotene can be metabolized to retinoids and other apo-carotenoids by the action of β-carotene 9’,10’-dioxygenase (BCO2). We found that Bco2 -/- female mice have significantly smaller hearts than wild-type (WT), pre- and post-puberty. Echocardiography revealed a significant increase in aortic blood flow velocity with no change in overall cardiac output. This analysis also suggests that the mutant has a smaller left ventricle with thinner walls. In addition, expression of cardiac foetal genes (BNP, α-Skeletal actinin and β-MyHc ), typically upregulated during embryogenesis or under pathological conditions in the adult, were significantly increased in the mutant. Bco2 -/- females showed impaired exercise capacity, displaying a ~40% reduction in running distance compared to WT. These data indicate functional cardiac defects in the mutant under stress conditions. Bco2 -/- females also displayed impaired cardiac metabolic flexibility. We found that Bco2 -/- mice have reduced Pdk4 expression and thus enhanced PDH activity. Cardiac expression of Glut1 and Mct1, key glucose and lactate transporters , were significantly higher in Bco2 -/- females, while triglyceride levels were lower in the heart and serum. These findings suggest preferential use of glucose as a cardiac energy source. Interestingly, the mutants had reduced cardiac retinoic acid levels (by LC-MS analysis) compared to WT. Retinoic acid upregulates Pdk4 , thus we postulated that retinoic acid deficiency contributes to loss of cardiac metabolic flexibility in Bco2 -/- females. Ongoing studies aim to confirm this hypothesis and determine if altered retinoic acid homeostasis is also linked to impaired postnatal heart growth in mutant mice. These findings give new insights into a potential role of the β-carotene metabolic pathway in regulating adult heart function.
Prognostic Value of TTM with TTM Distribution and Ball Score in Relapsed/Refractory Ibrutinib Treated B-CLL - in the Real-World Setting
Authors: Ozren Jaksic, Marija Ivic, Rajko Kusec, Zdravko Mitrovic, Mario Pirsic, Branimir Jaksic, David Cicic, Vlatko Pejsa
Journal: Blood (2020)
Predicting suicide attempt or suicide death following a visit to psychiatric specialty care: A machine learning study using Swedish national registry data
Authors: Qi Chen, Yanli Zhang-James, Eric J. Barnett, Paul Lichtenstein, Jussi Jokinen, Brian M. D’Onofrio, Stephen V. Faraone, Henrik Larsson, Seena Fazel
Journal: PLoS Medicine (2020)

Suicide is a major public health concern globally. Accurately predicting suicidal behavior remains challenging. This study aimed to use machine learning approaches to examine the potential of the Swedish national registry data for prediction of suicidal behavior.The study sample consisted of 541,300 inpatient and outpatient visits by 126,205 Sweden-born patients (54% female and 46% male) aged 18 to 39 (mean age at the visit: 27.3) years to psychiatric specialty care in Sweden between January 1, 2011 and December 31, 2012. The most common psychiatric diagnoses at the visit were anxiety disorders (20.0%), major depressive disorder (16.9%), and substance use disorders (13.6%). A total of 425 candidate predictors covering demographic characteristics, socioeconomic status (SES), electronic medical records, criminality, as well as family history of disease and crime were extracted from the Swedish registry data. The sample was randomly split into an 80% training set containing 433,024 visits and a 20% test set containing 108,276 visits. Models were trained separately for suicide attempt/death within 90 and 30 days following a visit using multiple machine learning algorithms. Model discrimination and calibration were both evaluated. Among all eligible visits, 3.5% (18,682) were followed by a suicide attempt/death within 90 days and 1.7% (9,099) within 30 days. The final models were based on ensemble learning that combined predictions from elastic net penalized logistic regression, random forest, gradient boosting, and a neural network. The area under the receiver operating characteristic (ROC) curves (AUCs) on the test set were 0.88 (95% confidence interval [CI] = 0.87-0.89) and 0.89 (95% CI = 0.88-0.90) for the outcome within 90 days and 30 days, respectively, both being significantly better than chance (i.e., AUC = 0.50) (p < 0.01). Sensitivity, specificity, and predictive values were reported at different risk thresholds. A limitation of our study is that our models have not yet been externally validated, and thus, the generalizability of the models to other populations remains unknown.By combining the ensemble method of multiple machine learning algorithms and high-quality data solely from the Swedish registers, we developed prognostic models to predict short-term suicide attempt/death with good discrimination and calibration. Whether novel predictors can improve predictive performance requires further investigation.
Radiographic read paradigms and the roles of the central imaging laboratory in neuro-oncology clinical trials
Authors: Benjamin M Ellingson, Matthew S Brown, Jerrold L Boxerman, Elizabeth R Gerstner, Timothy J Kaufmann, Patricia E Cole, Jeffrey A Bacha, David Leung, Amy Barone, Howard Colman, Martin J van den Bent, Patrick Y Wen, W K Alfred Yung, Timothy F Cloughesy, Jonathan G Goldin
Journal: Neuro-Oncology (2020)

Abstract Determination of therapeutic benefit in intracranial tumors is intimately dependent on serial assessment of radiographic images. The Response Assessment in Neuro-Oncology (RANO) criteria were established in 2010 to provide an updated framework to better characterize tumor response to contemporary treatments. Since this initial update a number of RANO criteria have provided some basic principles for the interpretation of changes on MR images; however, the details of how to operationalize RANO and other criteria for use in clinical trials are ambiguous and not standardized. In this review article designed for the neuro-oncologist or treating clinician, we outline essential steps for performing radiographic assessments by highlighting primary features of the Imaging Charter (referred to as the Charter for the remainder of this article), a document that describes the clinical trial imaging methodology and methods to ensure operationalization of the Charter into the workings of a clinical trial. Lastly, we provide recommendations for specific changes to optimize this methodology for neuro-oncology, including image registration, requirement of growing tumor for eligibility in trials of recurrent tumor, standardized image acquisition guidelines, and hybrid reader paradigms that allow for both unbiased measurements and more comprehensive interpretation.
Abstract 11695: Development and Validation of New Cardiovascular Disease Risk Scores for Patients With Diabetes Mellitus From a Pooled Cohort of the US Population
Authors: Yanglu Zhao, Ralph B D’Agostino, Alain G Bertoni, Matthew J Budoff, Adolfo Correa, Aaron Folsom, David R Jacobs, Shaista Malik, Elizabeth Selvin, Karol E Watson, Nathan D Wong
Journal: Circulation (2019)

Introduction: Existing cardiovascular disease (CVD) risk scores used in diabetes mellitus (DM) patients may be outdated, derived from single or clinical trial cohort, or designed for one endpoint. ...
Plasminogen Eye Drops Are Effective in Preventing Recurrence of Pseudomembranes in Ligneous Conjunctivitis: Results from the Phase 2/3 KB046 Trial
Authors: Roberto Caputo, Maria Teresa Sartori, Andrea Leonardi, Anna Lotti Suffredini, Mirella Calcinai, Roberto Crea, Prasad Mathew, Charles Nakar, Neelam Thukral, Amy D Shapiro
Journal: Blood (2020)
Oral Posaconazole or Intravenous-Oral Itraconazole in Preventing Invasive Fungal Diseases for Patients with Acute Leukemia
Authors: Li Liu, Xiaolei Pei, Runzhi Ma, Yi He, Rongli Zhang, Jialin Wei, Qiaoling Ma, Weihua Zhai, Erlie Jiang, Aiming Pang, Donglin Yang, Sizhou Feng, Ming-Zhe Han
Journal: Blood (2020)
The Role of D-Dimer for Optimal Thromboprophylaxis Strategy in Patients with COVID-19
Authors: Lantarima Bhoopat, Anastasia Martynova, April Choi, Pattharawin Pattharanitima, Semi Han, Senxi Du, Ibrahim Syed, Catherine Chan, Caitlin O'Neill, Esther Oh, Casey L. O'Connell
Journal: Blood (2020)
ZUMA-19: A Phase 1/2 Multicenter Study of Lenzilumab Use With Axicabtagene Ciloleucel (Axi-Cel) in Patients (Pts) With Relapsed or Refractory Large B Cell Lymphoma (R/R LBCL)
Authors: Saad S. Kenderian, Olalekan O. Oluwole, Philip L. McCarthy, Ran Reshef, Parveen Shiraz, Omar Ahmed, John Le Gall, Myrna Nahas, Lily Tang, Sattva S. Neelapu
Journal: Blood (2020)
SAT0197 Intestinal behcet’s disease and crohn?s disease: a radiological comperative study
Authors: U Korman, N Soylu, V Hamuryudan, S Kuruoglu, I Mihmanli, H Yazici
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> <h3>Objectives</h3> The aim of this study was to compare the enteroclysis findings in Behcet's disease (BD) and Crohn?s disease (CD). <h3>Methods</h3> From 1997 to 2000, seventeen patients with clinical suspicion of intestinal BD were examined by enteroclysis and radiological findings were compared to those seen in 50 Crohn?s cases. <h3>Results</h3> Twelve of 17 patients with BD showed findings of intestinal involvement in enteroclysis (70.58%). Disease duration and duration of intestinal involvement were 3–19 years (median 8.09 years) and 1 month-8 years (median 3.02 years) respectively. The findings were aphtous ulceration (n = 10), linear ulceration (n = 4), deep ulceration (n = 1), coarse granular pattern (n = 1), thickened folds (n = 5), wall thickening (n = 2), pseudopolypoid appereance of the ileocecal valve (n = 6), long segment involvement (n = 1), perforation and reccurrence at the side of anastomosis after right hemicolectomy (n = 1). In 50 Crohn?s cases, disease duration were 3 months-22 years (median 4.14 years). Ten cases were in the early,11 in the intermediate and 29 in the advanced radiological stage with or without complication. <h3>Conclusion</h3> Enteroclysis is the method of choice with a high accuracy rate (70.58%) for symptomatic patients to detect the intestinal pathology in BD. The enteroclysis findings in BD even when longstanding were usually mild when compared to those seen in CD. The main finding in BD was superficial ulceration. Deep ulceration common in CD was seen in only one patient with BD.
Creative Strategies Implemented During the Coronavirus Pandemic That Will Impact the Future of Cancer Care
Authors: Jessica Sugalski, Theresa Franco, Lawrence N. Shulman, Pelin Cinar, James Bachman, Jennie R. Crews, MiKaela Olsen, Alyssa Schatz, Timothy Kubal
Journal: Journal of the National Comprehensive Cancer Network (2021)

The coronavirus pandemic has significantly impacted operations at leading cancer centers across the United States. In the midst of the chaos, at least one silver lining has emerged: the development of new, creative strategies for delivering cancer care that are likely to continue post pandemic. The NCCN Best Practices Committee, which is composed of senior physician, nursing, and administrative leaders at NCCN Member Institutions, conducted a webinar series in June 2020 highlighting the most promising and effective strategies to date. Experts from NCCN Member Institutions participated in the series to share their experiences, knowledge, and thoughts about the future of cancer care.
Immune-Related Hematologic Adverse Events in the Context of Checkpoint Inhibitors
Authors: Antoine Saliba, Zhuoer Xie, Ally Higgins, Xavier A Andrade-Gonzalez, Harry E Fuentes-Bayne, Paul J. Hampel, Lionel Kankeu Fonkoua, Daniel Childs, Sagar Rakshit, Evandro D. Bezerra, Yanyan Lou, Candido E. Rivera, Katharine Price, Yiyi Yan, Anna Schwecke, Matthew S. Block, Uma Thanarajasingam, Gita Thanarajasingam, Alexandra P. Wolanskyj, Ariela L. Marshall, Lisa A Kottschade, Ronald S. Go, Aref Al-Kali
Journal: Blood (2020)
Venous Thromboembolism Prophylaxis Practices for Patients with Sickle Cell Disease Pre and during the COVID-19 Pandemic
Authors: Jennifer G. Davila, W. Beau Mitchell, Kerry A Morrone, Ellen J Silver, Caterina P Minniti, Henny H. Billett, Payal Desai, Sarah H. O'Brien, Deepa Manwani
Journal: Blood (2020)
Abstract 273: Utilization of Proximity-labeling to Identify Sarcomere Assembly Dependent Interactions
Authors: Feria Ladha, Ketan Thakar, Anthony PETTINATO, Nick Legere, Rachel Cohn, Robert Romano, Emily Meredith, Yu-sheng Chen, John Hinson
Journal: Circulation Research (2020)

The cardiac sarcomere is a multiprotein complex that generates pulsatile contractile force, enabling the heart to circulate vital nutrients, but its molecular components and dynamic interactions are incompletely understood. Cardiac alpha-actinin-2 (encoded by ACTN2 ; referred to as actinin) functions as the structural backbone of the Z-disc and is prone to mutations that result in human heart failure. We hypothesize that through identifying actinin PPIs at the Z-disc, we can identify new sarcomere functions and gain insights into heart failure pathogenesis. Until now, studying sarcomere PPIs has been challenging due to limitations in purifying intact sarcomere complexes and the inability to detect dynamic molecular interactions. To overcome this, we adapted BioID proximity proteomics to comprehensively study actinin PPIs in human induced pluripotent stem cells (hiPSCs) differentiated into cardiomyocytes (iCMs).We engineered an isogenic hiPSC line carrying an in-frame knock-in of BirA* , which encodes a promiscuous biotin ligase, at the ACTN2 locus. Upon differentiation into iCMs, the Actinin-BirA* fusion construct localizes to the Z-disc and, upon biotin supplementation, biotinylates vicinal proteins. We immunoprecipitated and analyzed Z-disc PPIs via quantitative tandem mass spectrometry. Among the &gt;100 PPIs detected by this method, we identified known interactions including sarcomere and focal adhesion proteins, but also new interactions including proteins involved in translation and metabolism. Furthermore, we wanted to better understand which of these protein interactions are dependent on sarcomere assembly and function, potentially elucidating interactions involved in normal cardiomyocyte biology and disease states. Through disruption of sarcomere assembly in our Actinin-BirA* model, we were also able to identify sarcomere-dependent actinin interactions including specific proteins involved in translation, the unfolded protein response, and glycolysis. Further investigation will allow us to better understand the proteomic network around actinin and provide novel insights into human sarcomere biology.
Recombinant Human Thrombopoietin in the Treatment of Chemotherapy-Induced Thrombocytopenia in Acute Myeloid Leukemia
Authors: Can Can, Lu Ding, Yuxin Tan, Balu Wu, Dongdong Zhang, Yanling Chen, Ziyi Luo, Xiaoyan Liu, Li Liu, Hui Shen, Fuling Zhou
Journal: Blood (2020)
Autologous Stem Cell Transplantation for Multiple Myeloma Patients Aged ≥ 75 Treated with Novel Agents
Authors: Iuliana Vaxman, Alissa Visram, Shaji K. Kumar, Angela Dispenzieri, Francis K. Buadi, David Dingli, Martha Q. Lacy, Eli Muchtar, Prashant Kapoor, William J Hogan, Suzanne R. Hayman, Nelson Leung, Wilson I Gonsalves, Taxiarchis Kourelis, Rahma M Warsame, Tamar Berger, Morie A. Gertz
Journal: Blood (2020)
AO-176, a Highly Differentiated Clinical Stage Anti-CD47 Antibody, Exerts Potent Anti-Tumor Activity in Preclinical Models of Multiple Myeloma As a Single Agent and in Combination with Approved Therapeutics
Authors: William Casey Wilson, John Richards, Robyn J Puro, Gabriela Andrejeva, Ben J Capoccia, Mike J Donio, Ronald R Hiebsch, Prabir Chakraborty, Victoria Sung, Daniel S Pereira
Journal: Blood (2020)
Effect of Nicotinamide, 1-Methylnicotinamide, and N'-Methylnicotinamide on Erythroid Colony Formation and γ-Globin Expression in Cultured Baboon CD34+ Cells
Authors: Donald Lavelle, Vinzon Ibanez, Kestis Vaitkus, Yogenthiran Saunthararajah, Robert E. Molokie
Journal: Blood (2020)
Molecular Predictors and Effectiveness of Measurable Residual Disease (MRD) Eradication with Chemotherapy and Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia
Authors: Maximilian Stahl, Andriy Derkach, Christopher Famulare, Christina Cho, Sean Devlin, Noushin Farnoud, Kamal Menghrajani, Minal A Patel, Sheng F Cai, Mark B. Geyer, Andrew Dunbar, Zachary D. Epstein-Peterson, Erin McGovern, Jessica Schulman, Jacob L Glass, Justin Taylor, Aaron D Viny, Eytan M. Stein, Bartlomiej Getta, Maria E. Arcila, Ross L. Levine, Juliet Barker, Brian C. Shaffer, Esperanza B. Papadopoulos, Boglarka Gyurkocza, Miguel-Angel Perales, Omar Abdel-Wahab, Elli Papaemmanuil, Sergio A. Giralt, Yanming Zhang, Mikhail Roshal, Martin S. Tallman, Aaron D Goldberg
Journal: Blood (2020)
Randomized Phase 2 Study of Weekly Carfilzomib 70 Mg/m2 and Dexamethasone Plus/Minus Cyclophosphamide in Relapsed and/or Refractory Multiple Myeloma (RRMM) Patients (GEM-KyCyDex)
Authors: Maria-Victoria Mateos, Enrique M. Ocio, Anna Sureda Balari, Albert Oriol, Esther González Garcia, Maria José Moreno, Miquel Granell, Fernando Escalante, Veronica Gonzalez De La Calle, Laura Rosinol Dachs, Estrella Carrillo-Cruz, Joaquín Martínez-López, Maria Victoria Dourdil Sahun, Marta Sonia Gonzalez, Jaime Perez De Oteyza, Felipe De Arriba, Miguel T Hernández, Aránzazu García Mateo, Ana Pilar Gonzalez, Rafael Rios, Carmen Cabrera, Juan Jose Bargay, Paula Rodriguez-Otero, Felipe Casado, Maria Casanova, María Jesús Blanchard, Joan Blade Creixenti, Juan Jose Lahuerta, Jesus F. San-Miguel
Journal: Blood (2020)
Treatment Decision-Making and Decisional Support Experiences Among Acute Myeloid Leukemia Survivors
Authors: Elissa C. Kranzler, Erica E. Fortune, Melissa F. Miller, Kelly Clark, Jemeille Ackourey, Linda Bohannon, Heather Badt, Thomas W. Leblanc, Jane L. Liesveld, Kristin Scheeler, Alexandra K Zaleta
Journal: Blood (2020)
Prognostic Impact of Hyperdiploidy on Multiple Myeloma in the Era of New Agents
Authors: Yi Wang, Jing Zhuang, Gang An, Xue-Han Mao, Chenxing Du, Jiahui Liu, Huishou Fan, Shuhui Deng, Yan Xu, Weiwei Sui, Lugui Qiu
Journal: Blood (2020)
Phase 1/2 Study of the Safety and Response of P-BCMA-101 CAR-T Cells in Patients with Relapsed/Refractory (r/r) Multiple Myeloma (MM) (PRIME) with Novel Therapeutic Strategies
Authors: Caitlin L. Costello, Adam D. Cohen, Krina K. Patel, Syed S Ali, Jesus G. Berdeja, Nina Shah, Siddhartha Ganguly, Mehmet Hakan Kocoglu, Mehrdad Abedi, Eric M. Ostertag, Chris E Martin, Majid Ghoddussi, Devon J Shedlock, Joanne McCaigue, Hamid Namini, Sreeni Yalamanchili, Matthew A. Spear, Tara K. Gregory
Journal: Blood (2020)
A novel STAT3 inhibitor W2014-S regresses human non-small cell lung cancer xenografts and sensitizes EGFR-TKI acquired resistance
Authors: Qiyao Zheng, Hui Dong, Jianshan Mo, Yi Zhang, Jie Huang, Shumin Ouyang, Shuo Shi, Kai Zhu, Xinming Qu, Wenhao Hu, Peiqing Liu, Yuanxiang Wang, Xiaolei Zhang
Journal: Theranostics (2020)

Constitutive activation of signal transducer and activator of transcription 3 (STAT3) is a common feature in human non-small cell lung cancer (NSCLC).STAT3 plays an important role in cancer progression as a driver oncogene and acquired resistance of targeted therapies as an alternatively activated pathway.W2014-S with pharmacophore structure of imidazopyridine, which was firstly reported to be utilized in STAT3 inhibitor discovery, was screened out as a potent STAT3 inhibitor from a library of small molecules.The aim of this study is to investigate the antitumor activities and mechanisms of W2014-S in NSCLC and effect on epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) resistance in vitro and in vivo.Methods: SPR analysis, Co-immunoprecipitation, confocal microscope imaging, and luciferase report gene assays were utilized to determine the mechanisms.Cell viability, colonial survival, wound healing, cell invasion assay, human cancer cell xenografts and PDX tumor xenografts were used to determine antitumor activities.Results: W2014-S disrupted STAT3 dimerization and selectively inhibited aberrant STAT3 signaling in NSCLC cell line.W2014-S strongly suppressed proliferation, survival, migration and invasion of lung cancer cells with aberrant STAT3 activation and inhibited the growth of human NSCLC cell xenografts and PDX tumor xenografts in mouse model.Furthermore, W2014-S significantly sensitized resistant NSCLC cell line to gefitinib and erlotinib in vitro and enhances the anti-tumor effect of gefitinib in TKI-resistant lung cancer xenografts in vivo.Conclusions: Our study has provided a novel STAT3 inhibitor with significant anti-tumor activities in NSCLC and suggests that combination of STAT3 inhibitor such as W2014-S with gefitinib could serve as a promising strategy to overcome EGFR-TKIs acquired resistance in NSCLC patients.