tbuckley/cabot-search huggingface dataset:
Roles of long non-coding RNAs and emerging RNA-binding proteins in innate antiviral responses
Authors: Yiliang Wang, Yun Wang, Weisheng Luo, Xiaowei Song, Lianzhou Huang, Ji Xiao, Fujun Jin, Zhe Ren, Yifei Wang
Journal: Theranostics (2020)

The diseases caused by viruses posed a great challenge to human health, the development of which was driven by the imbalanced host immune response. Host innate immunity is an evolutionary old defense system that is critical for the elimination of the virus. The overactive innate immune response also leads to inflammatory autoimmune diseases, which require precise control of innate antiviral response for maintaining immune homeostasis. Mounting long non-coding RNAs (lncRNAs) transcribed from the mammalian genome are key regulators of innate antiviral response, functions of which greatly depend on their protein interactors, including classical RNA-binding proteins (RBPs) and the unconventional proteins without classical RNA binding domains. In particular, several emerging RBPs, such as m6A machinery components, TRIM family members, and even the DNA binding factors recognized traditionally, function in innate antiviral response. In this review, we highlight recent progress in the regulation of type I interferon signaling-based antiviral responses by lncRNAs and emerging RBPs as well as their mechanism of actions. We then posed the future perspective toward the role of lncRNA-RBP interaction networks in innate antiviral response and discussed the promising and challenges of lncRNA-based drug development as well as the technical bottleneck in studying lncRNA-protein interactions. Our review provides a comprehensive understanding of lncRNA and emerging RBPs in the innate antiviral immune response.
THU0169 Early rheumatoid arthritis(era) in the aspect of differential diagnosis
Authors: AF Filipowicz-Sosnowska, MP Przygodzka, JZ Zabek
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> Difficulty in the diagnosis of early rheumatoid arthritis (ERA) in the aspect of differential diagnosis. <h3>Objectives</h3> The diagnosis of rheumatoid arthritis (RA) is based on ACR criteria, which are clinical, radiological and immunological. During the first month after onset the diagnosis is often difficult because of a frequently ?atypical? presentation and a lack of radiological changes. Rheumatoid factor has low specify and is often negative in ERA. The other non-rheumatological disorders (viral infection, neoplastic and endocrine diseases) may also in the early stage present like RA symptoms. The objective of this study was to revised the preliminary diagnosis of ERA in hospitalised patient. <h3>Methods</h3> Clinical examination (including laboratory tests and X ray), immunological tests: RF, antikeratin antibodies (AKA). <h3>Results</h3> During the last 26 month 510 RA patients (according ACR criteria) were hospitalised in Rheumatology Department. Among this group of patients 94 (18%) were admitted with the preliminary diagnosis ERA. All of this patients group fulfilled the first four clinical ACR criteria The duration of the disease was varied 3 to 9 months. All patients were carefully examined according number of painful and swollen joints, their symmetry and localisation, presence of RF, AKA antibodies and radiological erosions. In cases were RA diagnosis was doubtful other needful examination were done. The diagnosis of ERA was established in 48 (52%), but in 46 (48%) was excluded. ERA patients were predominately women, symmetrical polyarthris of the hands was present in 45 (52%). RF in 28 (58%), radiological erosions were found in 5 (10%). In group of patients with excluded ERA the following diagnosis was established: osteoarthritis 14 (31%), RA ? like (nonclassified) 13 (28%), reactive arthritis 3(7%), hepatitis viral infection 2 (4%), neo 2 (4%), Hashimoto syndrome 5 (11%), Sjogren syndrome 2 (4%), Polymialgia 2 (4%), Fibromialgia 3 (7%). AKA were present in 30 (62%) patients in group with established diagnosis of RA and RF was present in 28 (58%) patients in this group. AKA was present in 10 (21%) patients with different diagnosis and RF was observed in 8 (17%) patients in this group. <h3>Conclusion</h3> 1) ACR criteria are insufficient in aspect of differential diagnosis of ERA and non ERA. 2) Present RF and AKA are more specific in ERA than in non ERA patients.3) The diagnosis of ERA should be established by specialists. <h3>References</h3> Hassfeld W, Steiner G, Graninger W, Witzmann G, Schweitzer H, Smolen JS. Autoantibody to the nuclear antigen RA 33: a marker for early RA. Br J Rheumatol. 1993;32:199–203 Paimela L, Gripenberg M, Kuski P, Leirisalo ? Repo M. Antikeratin antibodies: diagnostic and progostic markers for early rheumatoid arthritis. Ann Rheum Dis. 1992;51:743–6
Comment on Ye<i>et al</i>‘Presence of respiratory failure of COVID-19 infection in rheumatism patients in Wuhan, China’
Authors: Xiao-Huan Chen, Chih-Jung Yeh, Han-You Mo, James Cheng Chung Wei
Journal: Annals of the Rheumatic Diseases (2020)

We read with great interest the article by Ye et al ,1 which reported the clinical features of COVID-19 in patients with rheumatic diseases, most notably that respiratory failure developed more commonly in patients with rheumatic disease infected with COVID-19 than those without rheumatic disease (38% vs 10%, p<0.001). The authors collected data from a total of 2326 patients with COVID-19 from 13 January to 15 March 2020, including 21 cases in combination with rheumatic disease, and conducted a retrospective case series study of their laboratory indices. However, some conclusions and findings in the study need to be further clarified.

First, the sample size of patients with rheumatic disease infected with COVID-19 was only 21—too small to extrapolate results with statistical confidence. Rheumatic diseases often affect the lungs, which can cause further damage to …
The Milroy Lectures on Quarantine: Delivered before the Royal College of Physicians of London, March, 1897
Authors: W. Collingridge
Journal: BMJ (1897)

MARCHIlonged operation, and, if so, free drainage will probably do all that is necessary.If the patient be in sufficiently good condition to permit a search for the rupture, and it can be found, it may be closed by fine silk or catgut sutures ; but, as a rule, it will be wise to open and drain the gall bladder at the same time.Should marked cholecystitis be found the question of cholecystectomy may be worth considering, but when the patient is in a critical condition it is a mistake to attempt too much, and, as a rule, cleansing and free drainage will be all that are necessary or advisable at the time, the removal of the cause beiDg left until the patient is better able to bear a pro- longed operation.
THU0263 LUNG INVOLVEMENT IN PRIMARY SJÖGREN SYNDROME – AN UNDER-DIAGNOSED ENTITY
Authors: G. Sogkas, S. Hirsch, K. Olsson, R. Schmidt, T. Witte, A. Jabonka, D. Ernst
Journal: Annals of the Rheumatic Diseases (2020)

Background: Interstitial lung disease (ILD) represents a frequent extra-glandular manifestation of primary Sjögren’s Syndrome (pSS). Limited published data regarding phenotyping and treatment exists. Advances in managing specific ILD phenotypes have not been comprehensively explored in patients with coexisting pSS. Objectives: This retrospective study aimed to phenotype lung diseases occurring in a well-described pSS cohort and describe treatment course and outcomes. Methods: Between April 2018 and September 2019, all pSS patients attending our Outpatient clinic were screened for possible lung involvement. Clinical, laboratory and computer tomography (CT) findings were analysed. Patients were classified according to CT findings into 5 groups: usual interstitial pneumonia (UIP), non-specific interstitial pneumonia (NSIP), desquamative interstitial pneumonia (DIP), combined pulmonary fibrosis and emphysema (CPFE) and unspecific-ILD. Results: Lung involvement was confirmed in 24/240 patients (10%). Clinically manifest pSS occurred later in patients with ILD vs. non-ILD (53.2 [42.0-61.7] vs. 62.3 [55.6-68.8] years; p=0.0016). The commonest phenotype was UIP n=10 (41%), followed by NSIP n=7 (29%), DIP n=2 (8%), CPFE n=2 (8%) and unspecific-ILD n=3 (13%). Forced vital capacity (FVC) and carbon monoxide diffusion capacity (D LCO ) appeared lower in UIP and DIP, without reaching a significant difference. Treatment focused universally on intensified immunosuppression, with 12/24 patients (50%) receiving cyclophosphamide. No anti-fibrotic treatments were used. Follow-up was median 13.2 [7.9-72.3] months, during which 6/24 (25%) patients exhibited a further decline in FVC. No deaths occurred. Conclusion: Lung involvement in pSS is heterogeneous. Better phenotyping and tailored treatment may improve outcomes and requires further evaluation in larger prospective studies. Disclosure of Interests: None declared
Muscle area and density and risk of all-cause mortality: The Multi-Ethnic Study of Atherosclerosis
Authors: Britta Larsen, John Bellettiere, Matthew Allison, Robyn L. McClelland, Iva Miljkovic, Chantal A. Vella, Pamela Ouyang, Kimberly R. De-guzman, Michael Criqui, Jonathan Unkart
Journal: Metabolism (2020)
Prognostic Impact of Clonal Hematopoiesis in Acute Myeloid Leukemia Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation in Complete Remission
Authors: Juliane Grimm, Marius Bill, Madlen Jentzsch, Stefanie Beinicke, Janine Häntschel, Karoline Goldmann, Julia Schulz, Michael Cross, Wolfram Pönisch, Vladan Vucinic, Gerhard Behre, Thoralf Lange, Georg-Nikolaus Franke, Dietger Niederwieser, Sebastian Schwind
Journal: Blood (2017)
Duodenal Microbiota in Stunted Undernourished Children with Enteropathy
Authors: Robert Y. Chen, Vanderlene L. Kung, Subhasish Das, M. Shabab Hossain, Matthew C. Hibberd, Janaki Guruge, Mustafa Mahfuz, S.M. Khodeza Nahar Begum, M. Masudur Rahman, Shah Mohammad Fahim, M. Amran Gazi, Rashidul Haque, Shafiqul A. Sarker, Ramendra N. Mazumder, Blanda Di Luccia, Kazi Ahsan, Elizabeth Kennedy, Jesus Santiago-Borges, Dmitry A. Rodionov, Semen A. Leyn, Andrei L. Osterman, Michael J. Barratt, Tahmeed Ahmed, Jeffrey I. Gordon
Journal: New England Journal of Medicine (2020)

Environmental enteric dysfunction (EED) is an enigmatic disorder of the small intestine that is postulated to play a role in childhood undernutrition, a pressing global health problem. Defining the incidence of this disorder, its pathophysiological features, and its contribution to impaired linear and ponderal growth has been hampered by the difficulty in directly sampling the small intestinal mucosa and microbial community (microbiota).
PTSD Treatments for Veterans
Authors: Paula P. Schnurr, Sonya B. Norman, Jessica L. Hamblen
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Multichannel optogenetic stimulation of the auditory pathway using microfabricated LED cochlear implants in rodents
Authors: Daniel Keppeler, Michael Schwaerzle, Tamas Harczos, Lukasz Jablonski, Alexander Dieter, Bettina Wolf, Suleman Ayub, Christian Vogl, Christian Wrobel, Gerhard Hoch, Khaled Abdellatif, Marcus Jeschke, Vladan Rankovic, Oliver Paul, Patrick Ruther, Tobias Moser
Journal: Science Translational Medicine (2020)

When hearing fails, electrical cochlear implants (eCIs) provide the brain with auditory information. One important bottleneck of CIs is the poor spectral selectivity that results from the wide current spread from each of the electrode contacts. Optical CIs (oCIs) promise to make better use of the tonotopic order of spiral ganglion neurons (SGNs) inside the cochlea by spatially confined stimulation. Here, we established multichannel oCIs based on light-emitting diode (LED) arrays and used them for optical stimulation of channelrhodopsin (ChR)-expressing SGNs in rodents. Power-efficient blue LED chips were integrated onto microfabricated 15-μm-thin polyimide-based carriers comprising interconnecting lines to address individual LEDs by a stationary or mobile driver circuitry. We extensively characterized the optoelectronic, thermal, and mechanical properties of the oCIs and demonstrated stability over weeks in vitro. We then implanted the oCIs into ChR-expressing rats and gerbils, and characterized multichannel optogenetic SGN stimulation by electrophysiological and behavioral experiments. Improved spectral selectivity was directly demonstrated by recordings from the auditory midbrain. Long-term experiments in deafened ChR-expressing rats and in nontreated control animals demonstrated specificity of optogenetic stimulation. Behavioral studies on animals carrying a wireless oCI sound processor revealed auditory percepts. This study demonstrates hearing restoration with improved spectral selectivity by an LED-based multichannel oCI system.
Epigenetic repression of miR-17 contributed to di(2-ethylhexyl) phthalate-triggered insulin resistance by targeting Keap1-Nrf2/miR-200a axis in skeletal muscle
Authors: Jie Wei, Qiongyu Hao, Chengkun Chen, Juan Li, Xikui Han, Zhao Lei, Tao Wang, Yinan Wang, Xiang You, Xiaoxuan Chen, Huasheng Li, Yuxin Ding, Weihao Huang, Yangyang Hu, Shuirong Lin, Heqing Shen, Yi Lin
Journal: Theranostics (2020)

Skeletal muscle insulin resistance is detectable before type 2 diabetes is diagnosed. Exposure to di(2-ethylhexyl) phthalate (DEHP), a typical environmental endocrine-disrupting chemical, is a novel risk factor for insulin resistance and type 2 diabetes. This study aimed to explore insulin signaling regulatory pathway in skeletal muscle of the DEHP-induced insulin-resistant mice and to investigate potential therapeutic strategies for treating insulin resistance.
Review of the French Working Group on Perioperative Hemostasis, French Study Group on Thrombosis and Hemostasis, and French Society for Anaesthesia and Intensive Care Guidelines on Management of Antiplatelet Therapy for Nonelective Invasive Procedures or Bleeding Complications
Authors: David P. Stonko, Elliott R. Haut
Journal: JAMA Surgery (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Use of Biomarkers in Individualization of Treatment
Authors: Jennifer J.D. Morrissette
Journal: Journal of the National Comprehensive Cancer Network (2020)

Next-generation sequencing (NGS), also known as massively parallel sequencing (MPS), offers broad detection of genetic alterations that, in approximately one-third of patients with cancer, are “actionable,” meaning that they can be targeted by available therapeutics or the detection of the alteration can lead to a change in therapy. NGS is useful in the diagnosis of patients, determining their prognosis, appropriate treatment selection, and clinical trial enrollment. Many testing panels are available, each with different abilities to detect various mutation types. Clinicians not only have to decide which test to use, but which specimen to test, and when and how often to test. Aside from unique mutations, immunotherapy markers have become important for the use of checkpoint inhibitors, and their detection and interpretation can also be challenging. Efforts are underway to simplify and validate these assays. Meanwhile, clinicians should become educated about the benefit of, means of, and interpretation of genomic testing patients across the disease course.
CT lung lesions as predictors of early death or ICU admission in COVID-19 patients
Authors: Yvon Ruch, Charlotte Kaeuffer, Mickael Ohana, Aissam Labani, Thibaut Fabacher, Pascal Bilbault, Sabrina Kepka, Morgane Solis, Valentin Greigert, Nicolas Lefebvre, Yves Hansmann, François Danion
Journal: Clinical Microbiology and Infection (2020)
Guselkumab safely improved clinical outcomes in biologic-naive patients with psoriatic arthritis
Authors: Ami Schattner
Journal: Annals of Internal Medicine (2020)

Source Citation Mease PJ, Rahman P, Gottlieb AB, et al. Guselkumab in biologic-naive patients with active psoriatic arthritis (DISCOVER-2): a double-blind, randomised, placebo-controlled phase 3 trial. Lancet. 2020;395:1126-36. 32178766
FRI0206 Plasma homocysteine levels in patients with systemic sclerosis
Authors: T Pirildar, N Turgan, E Tunc, T Turk, D Ozmen, G Keser, O Bayindir, E Doganavsargil
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> <h3>Objectives</h3> Homocysteine is a nonessential amino acid containing sulfur. Homocysteine has a toxic effect on the endothelium suggesting that it may take part in the etiopathogenesis of the diseases with vascular impairment. Since complex etiopathogenesis of systemic sclerosis (SSc) involves endothelial injury and activation, elevated plasma homocysteine levels might be expected in this disease. Standing from this point, we investigated plasma homocysteine levels in patients with limited (ISSc) and diffuse (dSSc) systemic sclerosis and in healthy controls. <h3>Methods</h3> Serum samples were collected from 59 (31 limited and 28 diffuse; F/M:56/3 male) patients with systemic sclerosis attending Ege University Rheumatology department, and 27 age and sex matched healthy controls were included in the study. Homocyteine was measured by high-performance liquid chromotography. Hyperhomocyteinemia may occur due to diabetes mellitus, hyperlipidemia and vitamin B12, folic acid deficiencies. Therefore, patients with these conditions excluded from the study. <h3>Results</h3> Statistical analysis was performed using one way analysis of varience test. All data are presented as mean = SD. A p value &lt;0.05 was accepted as statistically significant. Plasma homocyteine levels in patients with diffuse SSc (16.31 ± 5.916 mmol/L) and limited SSc (13.27 ± 8.352 mmol/L) were significantly higher than healthy controls (6.34 ± 1.540 mmol/L). When we compared the two subgroups of SSc, plasma homocystein levels in diffuse SSc, was significantly higher than limited SSc (F = 19.22 p &lt; 0.001). <h3>Conclusion</h3> Numerous clinical studies have been published on the association between homocysteine and vascular diseases. It has been shown to be cytotoxic to endothelium, to induce a vascular-endothelial cell activator, and to promote smooth muscle cell proliferation. Our finding of Significantly higher plasma homocysteine levels in the both subgroups of SSc implicate the contribution of hyperhomocysteinemia to endothelial damage in this disease.
SAT0007 BLOCKING HISTAMINE-RELEASING FACTOR/TRANSLATIONALLY CONTROLLED TUMOR PROTEIN (HRF/TCTP) ATTENUATES AGGRESSIVENESS OF FIBROBLAST-LIKE SYNOVIOCYTES AND AMELIORATES COLLAGEN-INDUCED ARTHRITIS IN RHEUMATOID ARTHRITIS
Authors: M. Kim, Y. Choe, H. Lee, Y. H. Cheon, S. I. Lee
Journal: Annals of the Rheumatic Diseases (2020)

Background: Histamine-releasing factor/translationally controlled tumor protein (HRF/TCTP) stimulates cancer progression and allergic responses. Increased expression of HRF/TCTP occurs in joints of rheumatoid arthritis (RA) patients, but the role of HRF/TCTP in RA remains undefined Objectives: In this study, we explored the pathogenic significance of HRF/TCTP and evaluated therapeutic effects of HRF/TCTP blockade in RA. Methods: HRF/TCTP transgenic (TG) and knockdown (KD) mice with collagen-induced arthritis (CIA) were used to determine experimental phenotypes of RA. HRF/TCTP levels were measured in sera and joint fluids in patients with RA and compared to those with osteoarthritis, ankylosing spondylitis, Behcet disease, and healthy controls. HRF/TCTP expression was also assessed in synovium and fibroblast-like synoviocytes (FLS) obtained from RA or OA patients. Finally, we assessed effects of HRF/TCTP and dimerized HRF/TCTP binding peptide-2 (dTBP2), an inhibitor of HRF/TCTP, in RA-FLS and CIA mice. Results: Our clinical, radiological, histological, and biochemical analyses indicate that inflammatory responses and joint destruction were increased in HRF/TCTP TG mice, and decreased in KD mice compared to wild-type littermates. HRF/TCTP levels were higher in sera, synovial fluid, synovium, and FLS of patients with RA than in control groups. Serum levels of HRF/TCTP correlated well with disease activity in RA. Tumor-like aggressiveness of RA-FLS was exacerbated by HRF/TCTP stimulation and ameliorated by dTBP2 treatment. dTBP2 exerted protective and therapeutic effects in CIA mice, and had no detrimental effect in a murine tuberculosis model. Conclusion: Our results indicate that HRF/TCTP represents a novel biomarker and therapeutic target for diagnosis and treatment of RA. References: N/A Acknowledgments : National Research Foundation of Korea Korea Health Industry Development Institute Disclosure of Interests: None declared
USPSTF recommends screening adults 18 to 79 years for hepatitis C virus infection (moderate certainty)
Authors: Ronald L. Koretz
Journal: Annals of Internal Medicine (2020)

Source Citation Owens DK, Davidson KW, Krist AH, et al. Screening for hepatitis C virus infection in adolescents and adults: US Preventive Services Task Force Recommendation Statement. JAMA. 2020;323:970-5. 32119076