tbuckley/cabot-search huggingface dataset:
Nonrigid reconstruction of 3D breast surfaces with a low-cost RGBD camera for surgical planning and aesthetic evaluation
Authors: R.M. Lacher, F. Vasconcelos, N.R. Williams, G. Rindermann, J. Hipwell, D. Hawkes, D. Stoyanov
Journal: Medical Image Analysis (2019)

Accounting for 26% of all new cancer cases worldwide, breast cancer remains the most common form of cancer in women. Although early breast cancer has a favourable long-term prognosis, roughly a third of patients suffer from a suboptimal aesthetic outcome despite breast conserving cancer treatment. Clinical-quality 3D modelling of the breast surface therefore assumes an increasingly important role in advancing treatment planning, prediction and evaluation of breast cosmesis. Yet, existing 3D torso scanners are expensive and either infrastructure-heavy or subject to motion artefacts. In this paper we employ a single consumer-grade RGBD camera with an ICP-based registration approach to jointly align all points from a sequence of depth images non-rigidly. Subtle body deformation due to postural sway and respiration is successfully mitigated leading to a higher geometric accuracy through regularised locally affine transformations. We present results from 6 clinical cases where our method compares well with the gold standard and outperforms a previous approach. We show that our method produces better reconstructions qualitatively by visual assessment and quantitatively by consistently obtaining lower landmark error scores and yielding more accurate breast volume estimates.
Dermatologists and Antibiotics—Reflecting on Our Habits, the Evidence, and Next Steps
Authors: Joslyn S. Kirby, Jordan S. Lim
Journal: JAMA Dermatology (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
AB1207 Correlation between clinical findings and ultrasonography in evaluating painful rheumatoid shoulder
Authors: M. Abdel Zaher, S. Tharwat, A. Abdel khalek, A. Abdel salam
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Shoulder pain is one of the most common complaints encountered in patients with rheumatoid arthritis (RA) <sup>1</sup>. In recent years ultrasonography (US) became an essential tool in diagnosing rheumatic diseases <sup>2</sup>. As clinical examination often does not allow an exact diagnosis, the agreement between both methods needs to be discussed to know how much the US add benefits to clinical examination. <h3>Objectives</h3> To determine the agreement between clinical examination and ultrasound in evaluating shoulder pain in rheumatoid. <h3>Methods</h3> A cross-sectional study including thirty RA patients, meeting the ACR/EULAR classification criteria for RA complaining of shoulder pain. They were recruited from rheumatology outpatient clinic in Mansoura University Hospitals. The sixty shoulders of the thirty patients were examined clinically by inspection, palpation and special tests, then fully examined by ultrasound including biceps tendon, subacromial bursa, rotator cuff tendons and acromioclavicular joint. <h3>Results</h3> Agreement among clinical examination and US was examined using Cohen's kappa. There was slight agreement between clinical examination and US regarding biceps tenosynovitis with k=0.206, fair agreement regarding acromioclavicular osteoarthritis with k=0.392 and SASD bursitis with k=0.233. There was also moderate agreement between clinical examination and US examination of the shoulder in case of supraspinatus tendinopathy with k=0.464. Data were statistically significant (p&lt;0.001). The overall agreement between clinical examination and ultrasound was poor. <h3>Conclusions</h3> Clinical examination of shoulder pain in rheumatoid arthritis is not accurate, insufficient. It should be confirmed with US examination during the initial evaluation of the shoulder to give reliable data and differentiate between different pathologies. <h3>References</h3> [1] Amin M, Ismail F,El-shereef R. The Role of Ultrasonography in Early Detection and Monitoring of Shoulder Erosions and Disease Activity in Rheumatoid Arthritis Patients; Comparison with MRI Examination. Acid Radiol2012;19(6):693–700. [2] Plaza M, Nowakowska-Plaza A., Pracon G., Sudol-szopinska I. Role of ultrasonography in the diagnosis of rheumatic diseases in light of ACR/EULAR guidelines. Journal of ultrasonography2016;16,55. <h3>Disclosure of Interest</h3> None declared
Abstract P327: Stress Overload and Methylation of Hypertension Related Genes
Authors: Kristen M Brown, Qin Hui, Cindy Crusto, Jacquelyn Y Taylor, Yan V Sun
Journal: Circulation (2018)

Background: Nearly 30% of U.S. adults are hypertensive with a high prevalence existing among Black Americans (42%). Exposure to psychosocial stress has been identified as a risk factor for hypertension and may explain part of the observed racial disparities. One pathway through which stress exposure may mechanistically alter biological functioning in a manner that affects risk of hypertension is via epigenetic modifications in hypertension-related genes, but this area remains understudied. Aims and Hypothesis: In the present study, we investigate the relationship between stress exposure and methylation of 25 genes that have been associated with blood pressure in Blacks in previous genetic research. We hypothesize that stress exposure is associated with DNA methylation of blood pressure related genes. Methods: We conducted an epigenetic association study using data from the ongoing InterGEN Study, a longitudinal investigation of the psychological, environmental, and genetic factors that contribute to hypertension risk in African American mothers (n=74) and their young children. Stress exposure was measured using the 24-item Stress Overload Scale (α=0.95), and a summary score was calculated by summing the Likert scale responses. Methylation was measured using the Illumina Infinium MethylationEPIC Beadchip, and M-values (i.e. log2 ratio of the intensities of methylated probe versus unmethylated probe) were calculated for association analysis. Linear regression was employed to assess the association between stress exposure and methylation in the a priori defined genes. Results: At p&lt;0.05, we identified 45 methylation sites associated with stress overload. These sites represented 17 of the 25 investigated genes. The most statistically significant sites were related to the genes: insulin like growth factor binding protein 3 ( IGFBP3 ), calcium voltage-gated channel subunit alpha1 H ( CACNA1H ), and solute carrier family 4 member 5 ( SLC4A5 ) (p=0.001, p=0.002, and p=0.006, respectively). Conclusion: This study provides biological insight into DNA methylation as a mechanism whereby exposure to psychosocial stress affects risk of hypertension in Black women. Additional replication studies with a larger sample size and includes men are needed to validate and generalize the findings. Future research should further investigate the biological mediators between DNA methylation and hypertension manifestation.
Clinical Practice Guidelines and the Need for Systematic Reviews
Authors: Kevin C. Wilson, Noah C. Schoenberg
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Critical Role for Apobec and Its Interacting Partners in Mediating Mutations and Cell Growth in Multiple Myeloma (MM)
Authors: Srikanth Talluri, Mehmet Kemal Samur, Jialan Shi, Rao Prabhala, Hervé Avet-Loiseau, Masood A. Shammas, Nikhil Munshi
Journal: Blood (2018)
Measurement of Tumor Antioxidant Capacity and Prediction of Chemotherapy Resistance in Preclinical Models of Ovarian Cancer by Positron Emission Tomography
Authors: Hannah E. Greenwood, Patrick N. McCormick, Thibault Gendron, Matthias Glaser, Raul Pereira, Oliver D. K. Maddocks, Kerstin Sander, Tong Zhang, Norman Koglin, Mark F. Lythgoe, Erik Årstad, Daniel Hochhauser, Timothy H. Witney
Journal: Clinical Cancer Research (2019)

Abstract Purpose: Drug resistance is a major obstacle for the effective treatment of patients with high-grade serous ovarian cancer (HGSOC). Currently, there is no satisfactory way to identify patients with HGSOC that are refractive to the standard of care. Here, we propose the system xc− radiotracer (4S)-4-(3-[18F]fluoropropyl)-l-glutamate ([18F]FSPG) as a non-invasive method to measure upregulated antioxidant pathways present in drug-resistant HGSOC. Experimental Design: Using matched chemotherapy sensitive and resistant ovarian cancer cell lines, we assessed their antioxidant capacity and its relation to [18F]FSPG uptake, both in cells and in animal models of human ovarian cancer. We identified the mechanisms driving differential [18F]FSPG cell accumulation and evaluated [18F]FSPG tumor uptake as predictive marker of treatment response in drug-resistant tumors. Results: High intracellular glutathione (GSH) and low reactive oxygen species corresponded to decreased [18F]FSPG cell accumulation in drug-resistant versus drug-sensitive cells. Decreased [18F]FSPG uptake in drug-resistant cells was a consequence of changes in intracellular cystine, a key precursor in GSH biosynthesis. In vivo, [18F]FSPG uptake was decreased nearly 80% in chemotherapy-resistant A2780 tumors compared with parental drug-sensitive tumors, with nonresponding tumors displaying high levels of oxidized-to-reduced GSH. Treatment of drug-resistant A2780 tumors with doxorubicin resulted in no detectable change in tumor volume, GSH, or [18F]FSPG uptake. Conclusions: This study demonstrates the ability of [18F]FSPG to detect upregulated antioxidant pathways present in drug-resistant cancer. [18F]FSPG may therefore enable the identification of patients with HGSOC that are refractory to standard of care, allowing the transferal of drug-resistant patients to alternative therapies, thereby improving outcomes in this disease.
The transcriptional regulator FUBP1 influences disease outcome in murine and human myeloid leukemia
Authors: Van T. Hoang, Divij Verma, Parimala Sonika Godavarthy, Pablo Llavona, Marlene Steiner, Katharina Gerlach, Birgitta E. Michels, Hanibal Bohnenberger, Astrid Wachter, Thomas Oellerich, Uta Müller-Kuller, Eva Weissenberger, Jenna M. Voutsinas, Vivian G. Oehler, Henner F. Farin, Martin Zörnig, Daniela S. Krause
Journal: Leukemia (2019)
OP0145 Scleroderma related interstitial lung disease and mycophenolate : long term outcomes
Authors: R. Janardana, A. Irodi, P.P. Chebbi, L. RV, D. danda, G. Mahasampath
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Interstitial lung disease [ILD] is a leading cause of mortality in scleroderma.<sup>1</sup> Scleroderma lung study-II clearly illustrates the equivalent efficacy and a better side-effect profile of mycophenolate mofetil [MMF] as compared to cyclophosphamide. <h3>Objectives</h3> To study the long term outcomes of mycophenolate mofetil in scleroderma related interstitial lung disease (SSc-ILD) in terms of change in forced vital capacity (FVC) To determine the effect of MMF on longitudinal high resolution computed tomography (HRCT) scores. <h3>Methods</h3> All patients of SSc-ILD from 2013 till date who had a baseline FVC and follow up FVC were taken for analysis. All patient received an average dose of 2 g/day of MMF for a median duration of 2 years and were tapered as per the standard protocol. FVC was measured using standard protocols. The FVC change was computed as percentage relative change from baseline FVC value. According to American Thoracic society recommendations, improvement is defined as an increase in FVC ≥10%, stabilisation by change in FVC &lt;10% and worsening by a reduction in FVC ≥10%. <h3>Results</h3> We had 88 patients with a baseline and followup FVC data. Of these 66 patients had a 1 year follow up; 46 patients had a 2 year followup and 29 patients had a 3 year followup data. The absolute median (IQR) increase in the FVC value at the end of 1 year, 2 years, 3 years were 4.15 (-2.3 to 10.5), 2.85 (-3.4 to 7.2) and 3.8 (-0.6 to 10.4) respectively. At the end of 1 year, 2 years and 3 years 89.4%; 82.6% and 75.9% respectively had a stable or improved relative FVC change from baseline. Of the 52 individuals who had a baseline as well as repeat HRCT, stable/improved scores in ground glass opacity, fibrosis and honey combing was seen in 80.8%, 86.5% and 86.5% respectively. There was no difference in the extent of FVC change between those with limited vs extensive disease. <h3>Conclusions</h3> A vast majority of individuals of scleroderma ILD patients on MMF in our cohort had a stable disease or improvement over short and long term followup both in terms of FVC change from baseline as well as HRCT scoring. <h3>Reference</h3> [1] Kazerooni EA, Martinez FJ, Flint A, et al. Thin-section CT obtained at 10-mm increments versus limited three-level thin- section CT for idiopathic pulmonary fibrosis: Correlation with pathologic scoring AJR. <i>Am J Roentgenol</i>1997Oct;169(4):977–83. <h3>Disclosure of Interest</h3> None declared
FRI0185 Factors determining work instability in patients with axial spondyloarthritis
Authors: A.S. Buche, L. Preston, N. Barkham
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Work instability is defined as mismatch between the employee's ability to work and the employer's expectations<sup>1</sup>. 50% of Ankylosing spondylitis patient lose their job due to disease activity and 50% of those in job face work instability and job retention problem<sup>2</sup>. Work disability is preceded by a period of work instability, which can be measured by the Ankylosing spondylitis work instability scale (ASWIS)<sup>1</sup>. <h3>Objectives</h3> To determine the factors responsible for work instability in patients with Axial spondyloarthritis (axSpA). <h3>Methods</h3> Patients attending the Spondyloarthritis clinic at a UK centre from 2013 to 2017, were included, if in employment, and diagnosed with axSpA according to ASAS criteria. Number of patients having low(WIS ≤10) and moderate to high (WIS 11–20) and corresponding parameters were noted. Numerical values were analysed using Spearman rank test and categorical values using Pearson's test. Multiple regression analysis was done. P value≤0.05 was considered significant. <h3>Results</h3> Of total 255 patients,139 were in employment (54.5%).97 were male and 42 were female. Mean age was 43.5 years (20–78 years). 59 patients in manual and 80 patients in non-manual job type, 52 had non-radiographic axSpA (nrSpA) and 87 had radiographic axSpA (rSpA). Mean diagnostic delay was 8 years (0–37 years). Mean ASWIS score was 10.43 (0–20). 75 patients (53.9%) were in Low WIS category and 64 (46%) in moderate to high WIS category. BASDAI and BASFI are found to be significantly correlating with WIS for the whole cohort. <h3>Conclusions</h3> Work instability is prevalent in axSpA, in all job types. Main factors contributing to work instability are disease activity (BASDAI) and function (BASFI). Drivers for work instability may be different in radiographic and non-radiographic patients. A prospective study will evaluate the impact of use of biologic on work instability. <h3>References</h3> [1] Gilworth G, Emery P, Barkham N, Tennant A, et al: Reducing work disability in Ankylosing spondylitis-development of a work instability scale for AS. BMC Musculoskeletal Disord2009;10:68. [2] Barkham N, Kong KO, Tennant A, Emery P, et al. The unmet need for anti-tumour necrosis therapy in ankylosing spondylitis. Rheumatology2005;44:1277–1281. <h3>Acknowledgements</h3> UCB contributed funding for part of this research, but had no input in collection, analysis of data or preparation of abstract. <h3>Disclosure of Interest</h3> None declared
SAT0139 Subclinical impairment of myocardial functionality during the very early stage of inflammatory joint diseases
Authors: A. Lo Gullo, J. Rodríguez-Carrio, F. Savarino, C. O. Aragona, G. Dattilo, C. Zito, A. Suárez, S. Loddo, M. Atteritano, A. Saitta, G. Mandraffino
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background:</h3> cardiovascular (CV) disease morbidity is increased in inflammatory joint diseases (IJD), as rheumatoid (RA) and psoriatic arthritis (PsA). Whereas accelerated subclinical atherosclerosis and endothelial dysfunction have been widely studied, less attention has been paid to myocardial function. RA patients with established disease who develop heart failure often have impaired left ventricular (LV) diastolic functionality with preserved LV ejection fraction (EF) and present fewer signs than non-RA patients. Then, additional and more sensitive screening tools as myocardial strain imaging are needed. In this sense, speckle-tracking echocardiography (STE) has been demonstrated to be suitable for detecting impaired systolic function. Although CV risk is increased at disease onset, whether abnormal myocardial functionality could be found already in the early phase of IJD remains unknown. <h3>Objectives:</h3> to evaluate the myocardial functionality by STE in recent onset RA and PsA patients and its associations with clinical features. <h3>Methods:</h3> STE was used to assess the myocardial functionality in patients with very early RA (n=41) (2010 EULAR/ACR criteria) and PsA (n=35) (CASPAR criteria) without traditional CV risk factors, and 58 matched healthy controls (HC). Global longitudinal and circumferential strain (GLS and GCS) were estimated. <h3>Results:</h3> RA patients exhibited impaired GLS (-18.13±1.36%) and GCS (-20.15±1.34%) compared to HC (-23.25±1.80%, p&lt;0.001 and -24.50±0.70%, p&lt;0.001; respectively), GLS being also altered in PsA (-21.57±2.59%, p=0.020 vs HC). No differences in LV mass index, posterior wall thickness, LV DD, E/A index or EF were found among groups (all p&gt;0.050). DAS28 was correlated to GLS (r=0.908, p&lt;0.001) and GCS (r=0.868, p&lt;0.001) in RA. These findings were further confirmed by multivariate regression analyses adjusted for age, gender, BMI, CRP, ESR, SBP, DBP and duration of the symptoms, DAS28 being the only independent predictor of GLS (p&lt;0.001) and GCS (p=0.002). Principal Component Analyses retrieved equivalent results. Although GCS was not significantly different in PsA compared to HC, a positive correlation with DAS28 (r=0.438, p=0.008) was observed. Consequently, GLS and GCS were impaired in PsA patients with high disease activity (DAS28&gt;2.9) compared to HC (GLS: p=0.066 and GCS: p=0.007). <h3>Conclusions:</h3> a subclinical myocardial dysfunction can be observed in IJD patients with preserved LV function and without traditional CV risk factors. The subclinical impairment of the myocardial function was found to be a very early event in IJD. Disease activity was the main predictor of myocardial strain impairment. Strain imaging by STE may detect early myocardial dysfunction in IJD. <h3>Disclosure of Interest:</h3> None declared
Abstract 19787: Hyperforin Activates Trpc6 Channels and Modulates Trpc6 and L-type Calcium Channel Crosstalk in Cardiomyocytes
Authors: Polina Gross, Jaslyn Johnson, Xiongwen Chen, Steven Houser
Journal: Circulation (2017)

Background: Transient receptor potential ion channel-6 (TRPC6) gene expression is upregulated in cardiac remodeling. TRPC6 mediated calcium (Ca2+) entry (TMCE) in cardiomyocytes (CMs) has been clas...
Abstract 20116: Ablation of Mmp9 Mitigates High Glucose-induced Cardiac Stem Cell Death
Authors: Santosh K Yadav, Paras K Mishra
Journal: Circulation (2017)

Biopsies from diabetes mellitus (DM) patients revealed that DM increases loss of cardiac stem cells (CSCs). However, the underlying molecular mechanism for CSCs loss is poorly understood. Apoptosis and/or pyroptosis (inflammatory form of apoptosis) are cell death mechanisms that may contribute to loss of CSCs in DM hearts. We have reported that matrix metalloproteinase-9 (MMP9) is upregulated in DM hearts. However, role of MMP9 in CSCs loss in DM is unclear. We hypothesized that upregulated MMP9 in DM hearts increases CSCs loss by inducing cell death mechanisms, especially apoptosis and pyroptosis. To test the hypothesis, we used human CSCs cell line and validated them for stem cell and cardiac origin markers. To determine the role of MMP9 in CSCs loss, we deleted MMP9 from CSCs using CRISPR/Cas9 and created CSCs/MMP9KO stable cell line. We treated CSCs and CSCsMMP9KO cells with 5mM (LG) and 25 mM (HG) doses of glucose for 24 hours and measured the levels of apoptosis and pyroptosis markers. For apoptosis...
Targeting NAD+ Modulating Enzymes to Improve HSC Function in Aging and Bone Marrow Failure
Authors: Phillip J Maciejewski, Yihong Guan, Metis Hasipek, Anand D. Tiwari, Dale Grabowski, James G Phillips, Yogenthiran Saunthararajah, Jaroslaw P. Maciejewski, Babal K. Jha
Journal: Blood (2018)
Autologous tumor cell–derived microparticle-based targeted chemotherapy in lung cancer patients with malignant pleural effusion
Authors: Mengfei Guo, Feng Wu, Guorong Hu, Lian Chen, Juanjuan Xu, Pingwei Xu, Xuan Wang, Yumei Li, Shuqing Liu, Shuai Zhang, Qi Huang, Jinshuo Fan, Zhilei Lv, Mei Zhou, Limin Duan, Tingting Liao, Guanghai Yang, Ke Tang, Bifeng Liu, Xiaofei Liao, Xiaonan Tao, Yang Jin
Journal: Science Translational Medicine (2019)

This study investigated the application of a therapeutic tumor cell–derived microparticle-based nanodelivery platform in malignant pleural effusion.
CD19-CAR Therapy Using Naive/Memory or Central Memory T Cells Integrated into the Autologous Stem Cell Transplant Regimen for Patients with B-NHL
Authors: Leslie Popplewell, Xiuli Wang, Suzette Blanchard, Jamie Wagner, Araceli Naranjo, Arencibia Adria, Jinny Paul, Laura Lim, Wen-Chung Chang, Elizabeth E Budde, Sandra Thomas, Christine Brown, Stephen J Forman
Journal: Blood (2018)