tbuckley/cabot-search huggingface dataset:
Intracellular Self‐Assembly of Peptide Conjugates for Tumor Imaging and Therapy
Authors: Yu Deng, Wenjun Zhan, Gaolin Liang
Journal: Advanced Healthcare Materials (2020)

Abstract Intracellular self‐assembly (ISA) is a versatile and powerful strategy for in situ constructing sophisticated and functional supramolecular nanostructures, which has been widely applied in biomedicine and biomedical engineering. Among the common building blocks for ISA, peptides have attracted increasingly attention due to their intrinsic bioactivity, biocompatibility, and biodegradability. Particularly, by conjugating functional motifs (e.g., probes or drugs) to peptides to yield the peptide conjugates, the latter show enhanced stability and efficiency, and probably new functions. In recent years, employing ISA of peptide conjugates for tumor imaging and treatment has achieved great progresses. Therefore, the recent progress of ISA of peptide conjugates is summarized in this progress report. Moreover, several examples of ISA of peptide conjugates for other important imaging or therapeutic applications are also introduced. Finally, a brief perspective on remaining challenges and potential directions for future research in this area is presented.
Walking the Gauntlet
Authors: Ronald D. Ennis
Journal: JAMA Oncology (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Efficacy of maintenance olaparib for newly diagnosed, advanced ovarian cancer patients with a BRCA mutation: subgroup analysis findings from the SOLO1 trial
Authors: Paul DiSilvestro, Nicoletta Colombo, Giovanni Scambia, Byoung-Gie Kim, Ana Oaknin, Michael Friedlander, Alla Lisyanskaya, Anne Floquet, Alexandra Leary, Gabe S Sonke, Charlie Gourley, Susana Banerjee, Amit Oza, Antonio González-Martín, Carol A Aghajanian, William H Bradley, Cara A Mathews, Joyce Liu, Elizabeth S Lowe, Ralph Bloomfield, Kathleen N Moore
Journal: Journal of Clinical Oncology (2020)
A Middle-aged Patient in a Coma 4 Weeks After Percutaneous Radiofrequency Ablation for Atrial Fibrillation
Authors: Damien Contou, Margot Deshons, Hervé Mentec
Journal: JAMA Cardiology (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Agonistic antibody to TRAIL-R1 (Mapatumumab) and low dose Bortezomib induce apoptosis in multiple myeloma while preserving dendritic cell function
Authors: Paul Neeson, Karen Chen, Tsin Tai, Amanda Shin, Kellie Tainton, Kate Fielding, Joanne Davis, H Prince, Robin Humphreys, David Ritchie
Journal: Cancer Research (2009)
Complete response to avelumab and IL-15 superagonist N-803 with Abraxane in Merkel cell carcinoma: a case study
Authors: Leylah Drusbosky, Chaitali Nangia, Andrew Nguyen, Christopher Szeto, Yulia Newton, Patricia Spilman, Sandeep Bobby Reddy
Journal: Journal for ImmunoTherapy of Cancer (2020)

Merkel cell carcinoma (MCC) is a rare aggressive form of skin cancer originating in neuroendocrine cells. The antiprogrammed death ligand 1 (PD-L1) monoclonal antibody (mAb) avelumab has been approved for treatment of MCC, but options are limited, should it be ineffective as a monotherapy. Combined therapy with low/moderate dose nab-paclitaxel and an interleukin 15 (IL-15)-based therapeutic such as the IL-15 ‘superagonist’ N-803 may increase response by activation of the immune system. The case of a 71-year-old man diagnosed with MCC who achieved and maintained a complete response (CR) by treatment with the anti-PD-L1 mAb avelumab in combination with IL-15 superagonist N-803 and nab-paclitaxel (Abraxane) is presented. Avelumab treatment alone resulted in a response in a para-aortic lesion, but not the other tumor masses. N-803 was added, followed by nab-paclitaxel; CT showed a decrease in the size of the abdominal mass at 1 month, near resolution at 3 months and CR at 5 months. Abraxane was discontinued after the first CR on CT, and the patient continues on avelumab/N-803 treatment and maintains a CR. Combination of avelumab with low/moderate-dose chemotherapy and an immune enhancer such as N-803 may offer a viable treatment option for MCC patients for whom avelumab therapy alone was not effective.
Role for caveolin-mediated transcytosis in facilitating transport of large cargoes into the brain via ultrasound
Authors: Rucha Pandit, Wee Kiat Koh, Robert K.P. Sullivan, Tishila Palliyaguru, Robert G. Parton, Jürgen Götz
Journal: Journal of Controlled Release (2020)

The blood-brain barrier (BBB) is a dynamic diffusional barrier regulating the molecular and chemical flux between the blood and brain, thereby preserving cerebral homeostasis. Endothelial cells form the core anatomical component of the BBB based on properties such as specialized junctional complexes between cells, which restricts paracellular transport, and extremely low levels of vesicular transport, restricting transcytosis. In performing its protective function, the BBB also constrains the entry of therapeutics into the brain, hampering the treatment of various neurological disorders. Focused ultrasound is a novel therapeutic modality that has shown efficacy in transiently and non-invasively opening the BBB for the targeted delivery of therapeutics to the brain. Although the ability of ultrasound to disrupt the junctional assembly of endothelial cells has been partially investigated, its effect on the transcellular mode of transport has been largely neglected. In this study, we found that ultrasound induces a pronounced increase in the levels of the vesicle-forming protein caveolin-1. In order to investigate the role of vesicle-mediated transcytoplasmic transport, we compared the leakage of various cargo sizes between a mouse model that lacks caveolin-1 and wild-type mice following sonication of the hippocampus. The absence of caveolin-1 did not lead to overt abnormalities in the cerebral vasculature in the mice. We found that caveolin-1 has a critical role specifically in the transport of large (500 kDa), but not smaller (3 and 70 kDa) cargoes. Our findings indicate differential effects of therapeutic ultrasound on cellular transport mechanisms, with implications for therapeutic interventions.
Apgar Score—It Is Time to Avoid Pain
Authors: Carlo V. Bellieni
Journal: JAMA Pediatrics (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Wireless Programmable Recording and Stimulation of Deep Brain Activity in Freely Moving Humans
Authors: Uros Topalovic, Zahra M. Aghajan, Diane Villaroman, Sonja Hiller, Leonardo Christov-Moore, Tyler J. Wishard, Matthias Stangl, Nicholas R. Hasulak, Cory S. Inman, Tony A. Fields, Vikram R. Rao, Dawn Eliashiv, Itzhak Fried, Nanthia Suthana
Journal: Neuron (2020)
Quality and Safety in Healthcare, Part LXXXI
Authors: Jay A. Harolds, Laura B. Miller
Journal: Clinical Nuclear Medicine (2020)

Abstract When the “Standards for Establishing and Sustaining Healthy Work Environments” set forth by the American Association of Critical-Care Nurses are met in a health care system, there is enhanced safety and quality care for the patient, better job satisfaction, and less turnover by the staff. The American Association of Critical-Care Nurses started the Beacon Award for Excellence not only to recognize those who have such high standards but also to encourage units who already have achieved this distinction or are applying for it to do better.
IgG4-related sclerosing cholangitis presenting as an isolated intrahepatic stenosis: a rare presentation of a rare disease
Authors: Aymeric Becq, Marine Camus, Lionel Arrivé, Thevy Hor, Doryan Amoodadashi, Louis Buscail, Ulriikka Chaput
Journal: Endoscopy (2020)

A 36-year-old woman with no significant past medical history presented with fatigue and a 5-kg weight loss. Blood work-up showed isolated elevated γ-glutamyltransferase (3 × upper limit of normal). Magnetic resonance cholangiopancreatography (MRCP) demonstrated a short stricture of the left main intrahepatic duct (IHD) with upstream dilatation of the IHDs ([Fig. 1]). The biliary tract was otherwise unremarkable.
Enhance the Efficacy of Doxorubicin Destabilizing the G2/M Checkpoint with a CHK1/CHK2 Inhibitor Pre-Treatment on Acute Lymphoblastic Leukemia
Authors: Andrea Ghelli Luserna di Rora, Anna Ferrari, Enrica Imbrogno, Valentina Robustelli, Cristina Papayannidis, maria Chiara Abbenante, Giovanni Marconi, Michele Cavo, Giovanni Martinelli
Journal: Blood (2017)
Complex genetic signatures in immune cells underlie autoimmunity and inform therapy
Authors: Valeria Orrù, Maristella Steri, Carlo Sidore, Michele Marongiu, Valentina Serra, Stefania Olla, Gabriella Sole, Sandra Lai, Mariano Dei, Antonella Mulas, Francesca Virdis, Maria Grazia Piras, Monia Lobina, Mara Marongiu, Maristella Pitzalis, Francesca Deidda, Annalisa Loizedda, Stefano Onano, Magdalena Zoledziewska, Stephen Sawcer, Marcella Devoto, Myriam Gorospe, Gonçalo R. Abecasis, Matteo Floris, Mauro Pala, David Schlessinger, Edoardo Fiorillo, Francesco Cucca
Journal: Nature Genetics (2020)
Iron Induces Cell Death and Strengthens the Efficacy of Antiandrogen Therapy in Prostate Cancer Models
Authors: Jessica Bordini, Federica Morisi, Angela Rita Elia, Paolo Santambrogio, Alessia Pagani, Vito Cucchiara, Paolo Ghia, Matteo Bellone, Alberto Briganti, Clara Camaschella, Alessandro Campanella
Journal: Clinical Cancer Research (2020)

Abstract Purpose: In search of novel strategies to improve the outcome of advanced prostate cancer, we considered that prostate cancer cells rearrange iron homeostasis, favoring iron uptake and proliferation. We exploited this adaptation by exposing prostate cancer preclinical models to high-dose iron to induce toxicity and disrupt adaptation to androgen starvation. Experimental Design: We analyzed markers of cell viability and mechanisms underlying iron toxicity in androgen receptor–positive VCaP and LNCaP, castration-resistant DU-145 and PC-3, and murine TRAMP-C2 cells treated with iron and/or the antiandrogen bicalutamide. We validated the results in vivo in VCaP and PC-3 xenografts and in TRAMP-C2 injected mice treated with iron and/or bicalutamide. Results: Iron was toxic for all prostate cancer cells. In particular, VCaP, LNCaP, and TRAMP-C2 were highly iron sensitive. Toxicity was mediated by oxidative stress, which primarily affected lipids, promoting ferroptosis. In highly sensitive cells, iron additionally caused protein damage. High-basal iron content and oxidative status defined high iron sensitivity. Bicalutamide–iron combination exacerbated oxidative damage and cell death, triggering protein oxidation also in poorly iron-sensitive DU-145 and PC-3 cells. In vivo, iron reduced tumor growth in TRAMP-C2 and VCaP mice. In PC-3 xenografts, bicalutamide–iron combination caused protein oxidation and successfully impaired tumor expansion while single compounds were ineffective. Macrophages influenced body iron distribution but did not limit the iron effect on tumor expansion. Conclusions: Our models allow us to dissect the direct iron effect on cancer cells. We demonstrate the proof of principle that iron toxicity inhibits prostate cancer cell proliferation, proposing a novel tool to strengthen antiandrogen treatment efficacy.
Outcomes of lenalidomide‐ or bortezomib‐based regimens in older patients with plasma cell myeloma
Authors: Peter Barth, Smith Giri, John L Reagan, Adam J Olszewski
Journal: American Journal of Hematology (2020)

The "triplet" regimen of lenalidomide, bortezomib, and dexamethasone (RVD) showed survival advantage over lenalidomide-dexamethasone (RD) in clinical trials, but older patients with myeloma often receive doublet regimens (RD or bortezomib-dexamethasone, VD), or VD plus cyclophosphamide (VCD). We compared these first-line regimens using real-world data from Medicare beneficiaries receiving therapy between 2007 and 2015. In each comparative analysis, we balanced confounding characteristics using a propensity score. Outcomes included overall (OS) and event-free survival (EFS, reporting hazard ratios [HR] with 95% confidence intervals [CI]), adverse events, and costs. We identified 6076 patients with median age 76 and median OS of 2.6 years. In the comparison of RVD vs RD/VD doublets, RVD showed significantly better OS (HR = 0.83; 95% CI, 0.72-0.95) and EFS (HR = 0.68; 95% CI, 0.61-0.76). So, RVD was associated with more frequent hospitalizations, anemia, and neuropathy, but no increase in thromboembolism or secondary cancers. Costs were higher with RVD. In the comparison of RD vs VD, RD demonstrated better EFS (HR = 0.74; 95% CI, 0.68-0.81) and marginally better OS (HR = 0.91; 95% CI, 0.83-0.99). And, RD resulted in significantly more thromboembolic events, less neuropathy, and no significant difference in hospitalizations, transfusions, or secondary cancers. In the comparison of VCD vs VD, we observed no significant difference in any outcome. Superior survival favors RVD over doublet regimens, but even in 2015 RVD was applied for only about 25% of Medicare beneficiaries with myeloma. For patients not eligible for RVD due to toxicity, VCD offers no survival benefit over VD. Lenalidomide-dexamethasone may be the preferred line doublet considering its advantage over VD.
Abstract 15785: Inhibition of p16INK4a Protects Against Myocardial Ischemia/Reperfusion Injury
Authors: Yihua Bei, Xiangmin Meng, Qiulian Zhou, Junjie Xiao
Journal: Circulation (2018)

Background: The apoptosis of cardiomyocytes is an essential pathological process in myocardial ischemia/reperfusion (I/R) injury. p16INK4a is a cyclin kinase inhibitor, while inhibition of p16INK4a...
Abstract 16479: A Conserved HH-Gli1-Mycn Network Regulates Heart Regeneration
Authors: Bhairab N Singh, Wuming Gong, Ivan Moskowitz, Elizabeth Braunlin, Satyabrata Das, Jop Van Berlo, Mary Garry, Daniel Garry
Journal: Circulation (2018)

Background: The mammalian heart has a limited regenerative capacity and typically progresses to heart failure following injury. Understanding the underlying mechanisms and signaling pathways that p...
Association of Adjuvant Chemotherapy With Overall Survival Among Women With Small, Node-Negative, Triple-Negative Breast Cancer
Authors: Oluwadamilola T. Oladeru, Anurag K. Singh, Sung Jun Ma
Journal: JAMA Network Open (2020)

This cohort study uses data from the National Cancer Database to evaluate overall survival rates of women who were diagnosed between 2010 and 2015 with small, node-negative, triple-negative breast cancer and were treated with or without adjuvant chemotherapy.
Surgery during covid-19: co-producing patient resources
Authors: Mary L Venn, Carrie Tierney Weir
Journal: BMJ (2020)

Surgical patients are facing new territory. On the one hand they hear that elective surgery carries an increased risk of getting covid-19, on the other, that delaying surgery may cause problems, and that operations can be done safely when precautions are taken. In this article, <b>Mary Venn</b>, surgical research fellow, and <b>Carrie Tierney Weir</b>, a patient with inflammatory bowel disease, describe how their collaborative group, CovidSurg, has worked with patients to rapidly produce information resources about the risks of surgery during the pandemic.
Consent to Trainee Involvement in Pediatric Care
Authors: Emily A Largent
Journal: New England Journal of Medicine (2020)

Interview with Dr. Michael Greene on considerations regarding the consent process for procedures performed by medical students and residents. (09:09)Download Consent to the involvement of students, interns, and residents in the care of children has received scant attention as compared with consent for either care or research. But there are compelling reasons for routinely obtaining children’s assent to trainee involvement.
Phase I Study of Cabozantinib and Nivolumab Alone or With Ipilimumab for Advanced or Metastatic Urothelial Carcinoma and Other Genitourinary Tumors
Authors: Andrea B. Apolo, Rosa Nadal, Daniel M. Girardi, Scot A. Niglio, Lisa Ley, Lisa M. Cordes, Seth M. Steinberg, Olena Sierra Ortiz, Jacqueline Cadena, Carlos Diaz, Marissa Mallek, Nicole N. Davarpanah, Rene Costello, Jane B. Trepel, Min-Jung Lee, Maria J. Merino, Mohammad Hadi Bagheri, Paul Monk, William D. Figg, James L. Gulley, Piyush K. Agarwal, Vladimir Valera, Heather J. Chalfin, Jennifer Jones, Howard Streicher, John J. Wright, Yangmin M. Ning, Howard L. Parnes, William L. Dahut, Donald P. Bottaro, Primo N. Lara, Biren Saraiya, Sumanta K. Pal, Mark N. Stein, Amir Mortazavi
Journal: Journal of Clinical Oncology (2020)

We assessed the safety and efficacy of cabozantinib and nivolumab (CaboNivo) and CaboNivo plus ipilimumab (CaboNivoIpi) in patients with metastatic urothelial carcinoma (mUC) and other genitourinary (GU) malignances.
Cardiovascular Magnetic Resonance Findings in Competitive Athletes Recovering From COVID-19 Infection
Authors: Saurabh Rajpal, Matthew S. Tong, James Borchers, Karolina M. Zareba, Timothy P. Obarski, Orlando P. Simonetti, Curt J. Daniels
Journal: JAMA Cardiology (2020)

This study investigates the use of cardiac magnetic resonance imaging in competitive athletes who recovered from coronavirus disease 2019 (COVID-10) to detect myocardial inflammation that would identify high-risk athletes for return to competitive play.
PRPS-ST: A Protocol-Agnostic Self-training Method for Gene Expression–Based Classification of Blood Cancers
Authors: Aixiang Jiang, Laura K. Hilton, Jeffrey Tang, Christopher K. Rushton, Bruno M. Grande, David W. Scott, Ryan D. Morin
Journal: Blood Cancer Discovery (2020)

Gene expression classifiers are gaining increasing popularity for stratifying tumors into subgroups with distinct biological features. A fundamental limitation shared by current classifiers is the requirement for comparable training and testing data sets. Here, we describe a self-training implementation of our probability ratio-based classification prediction score method (PRPS-ST), which facilitates the porting of existing classification models to other gene expression data sets. In comparison to gold standards, we demonstrate favorable performance of PRPS-ST in gene expression-based classification of DLBCL and B-ALL using a diverse variety of gene expression data types and pre-processing methods, including in classifications with a high degree of class imbalance. Tumors classified by our method were significantly enriched for prototypical genetic features of their respective subgroups. Interestingly, this included cases that were unclassifiable by established methods, implying the potential enhanced sensitivity of PRPS-ST.