tbuckley/cabot-search huggingface dataset:
Lenalidomide, Adriamycin and Dexamethasone (RAD) Versus Bortezomib, Lenalidomide and Dexamethasone (VRD) in Newly Diagnosed Multiple Myeloma (MM) - Post-Induction Response and MRD Results By Flow Cytometry and NGS from a Phase 3 Randomized Controlled Clinical Trial (RCT)
Authors: Thomas Stübig, Christian Langer, Monika Engelhardt, Lars-Olof Mügge, Florian Bassermann, Martin Schreder, Kerstin Schäfer-Eckart, Igor Wolfgang Blau, Denise Wolleschak, Albrecht Reichle, Ivana Metzler, Bernd Metzner, Christoph Rollig, Bernd Hertenstein, Heinz Dürk, Harald Biersack, Helge Menzel, Tobias Dechow, Jan Schleicher, Martin Gramatzki, Tim H. Brümmendorf, Stephan Fuhrmann, Max Bittrich, Franziska Appelt, Martina Müller, Jan Krönke, Julia Reusch, Christian Schmidt, Monika Brüggemann, Swantje Held, Stefan Knop, Hermann Einsele
Journal: Blood (2018)
De-Escalation of Antimicrobials in Adult Hematopoietic Cell Transplantation Recipients with Febrile Neutropenia of Unknown Origin
Authors: Megan M. Petteys, Ekaterina Kachur, Kelly E. Pillinger, Jiaxian He, James T. Symanowski, Candace M. Butler, Lynn S. Sanders, Nilanjan Ghosh, Michael R. Grunwald, Belinda Rene Avalos, Saad Z. Usmani, Edward A. Copelan, Zainab Shahid
Journal: Blood (2018)
Pyrimido-Indole Derivative, UM171 Expands Distinct Types of Myeloid and Lymphoid Progenitors from Human Pluripotent Stem Cells
Authors: Walatta-Tseyon Mesquitta, Hyunjun Kang, Matthew Wandsnider, Vera Brok-Volchanskaya, Kran Suknuntha, Igor Slukvin
Journal: Blood (2018)
COMT and Alpha-Tocopherol Effects in Cancer Prevention: Gene-Supplement Interactions in Two Randomized Clinical Trials
Authors: Kathryn T Hall, Julie E Buring, Kenneth J Mukamal, M Vinayaga Moorthy, Peter M Wayne, Ted J Kaptchuk, Elisabeth M Battinelli, Paul M Ridker, Howard D Sesso, Stephanie J Weinstein, Demetrius Albanes, Nancy R Cook, Daniel I Chasman
Journal: JNCI Journal of the National Cancer Institute (2018)

Vitamins are among the most frequently used supplements (48% of US adults). However, little is known about contributions of genetic variation to their efficacy and safety. Multiple pathways link catechol-O-methyltransferase (COMT) to the vitamin E supplement, alpha-tocopherol, and cancer.
Abstract 14012: Alkaline Phosphatase: An Alternative Inflammatory Risk Marker After Coronary Syndrome
Authors: Gregory G Schwartz, Anders G Olsson, Christie M Ballantyne, Philip Barter, David Kallend, Lawrence A Leiter, Eran Leitersdorf, John J McMurray, Stephen J Nicholls, Prediman K Shah, Jean-Claude Tardif, John Kittelson
Journal: Circulation (2017)

Introduction: Alkaline phosphatase (AP) may promote progression of atherosclerosis and vascular calcification. Like high sensitivity C-reactive protein (hsCRP), AP is also an inflammatory marker an...
AB0820 Anti-ks autoantibody is associated with sicca syndrome and interstitial lung disease
Authors: Y. Kondo, S. Sasaki, T. Kurabayashi, Y. Koyama, S. Sato
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Anti-aminoacyl-tRNA synthetase (anti-ARS) autoantibodies have been found in patients with polymyositis/dermatomyositis (PM/DM). Anti-KS, an anti-ARS antibody, often presents with interstitial lung disease (ILD) without other clinical symptoms of connective tissue disease (CTD). However, the clinical manifestations of anti-KS-positive patients are not well-studied. <h3>Objectives</h3> To clarify the clinical and laboratory characteristics of Japanese patients with antibodies against anti-KS antibody. <h3>Methods</h3> Sera from 326 patients with CTD (including PM/DM) or ILD at Tokai University were screened for anti-KS antibody using RNA and protein immunoprecipitation assays. Demographic data, clinical symptoms, laboratory findings and chest computed tomography (CT) scan results were retrospectively reviewed from medical charts. <h3>Results</h3> Five patients with anti-KS autoantibody were identified. All five patients were female with a mean age (±SD) of 59.4 (±13.9) years at onset, presenting with respiratory symptoms without any sign of myositis. In all patients, ILD was chronic and chest CT scan revealed a non-specific interstitial pneumonia pattern in three patients and the remaining two showed a usual interstitial pneumonia pattern. Three patients (60%) had arthritis, mechanic's hand, while one (20%) had Gottron's sign and was diagnosed as amyopathic DM with ILD. Interestingly, three patients (60%) showed symptoms of the Sicca syndrome with presence of anti-SSA antibody and two of those were diagnosed as Sjögren's syndrome. The frequency of Sicca syndrome in anti-KS-positive patients was significantly higher compared with other anti-ARS antibody-positive patients (60% vs. 14%, respectively, p=0.031) <h3>Conclusions</h3> These results highlight that the presence of anti-KS antibody is associated with the Sicca syndrome as well as ILD without muscle symptoms. <h3>References</h3> [1] Hirakata M, et al. J Immunol. 1999Feb 15;162(4):2315–20. [2] Hirakata M, et al. Arthritis Rheum. 2007Apr;56(4):1295–303. <h3>Disclosure of Interest</h3> None declared
Doubling NHS surcharge “punishes” international doctors for working in UK, says BMA
Authors: Matthew Limb
Journal: BMJ (2019)

The UK government is maintaining a “hostile environment” for overseas medics by doubling a levy paid by migrants seeking to work here, doctors’ leaders have warned.

The BMA said that the Home Office’s decision to raise the immigration health surcharge from £200 (€221; $255) to £400 a year was “absurd” and would “punish” international doctors working in the NHS at a time of major staffing shortages.

A BMA spokesperson said, “With Brexit mere weeks away, Britain must present itself as a welcoming and attractive place for doctors and other international healthcare workers to come and work.

“However, this move sends the exact opposite message and does nothing …
Progress in the HIV epidemic: Identifying goals and measuring success
Authors: Jeb Jones, Patrick S. Sullivan, James W. Curran
Journal: PLoS Medicine (2019)

Substantial progress has been made towards the goal of ending the HIV/AIDS epidemic due to advancements in both prevention and treatment of HIV. However, major challenges still remain. We describe basic principles of epidemic control in the context of HIV and identify a number of attainable goals in terms of control and elimination of HIV in specific populations and risk groups, given currently available HIV prevention and treatment methods. Currently available HIV prevention methods make it a feasible goal to eliminate HIV transmission attributable to mother-to-child transmission and blood transfusions. Reductions in transmission attributable to sexual behavior and injection drug use are feasible, but elimination of these modes of transmission will require further advancements in behavioral and biomedical HIV prevention. With regard to HIV-related mortality, we argue that elimination of death due to HIV-related causes is a feasible goal. HIV-related deaths should be treated as sentinel events triggering epidemiological investigation into the breakdowns in the HIV care continuum that led to them. We briefly discuss additional considerations that will affect the success of HIV prevention programs.
AB0284 Relationship of biomarkers, ultrasound (US) signs of joint damage and radiographic progression in patients with rheumatoid arthritis(RA)
Authors: O. Alekseeva, T. Saykovskaya, A. Smirnov, A. Volkov, E. Nasonov
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Rheumatoid arthritis (RA) is a chronic inflammatory immune-mediated disease, based on the imbalance of biomarkers, leading to the appearance of inflammatory changes in the joints, the progression of bone and cartilage destruction. <h3>Objectives</h3> to identify the relationship between cytokines, their dynamic changes, ultrasound (US) signs and radiologic progression in 12 month prospective study in patients RA. <h3>Methods</h3> 35 patients (median age 55.0 [48.0; 64.0] years) with early RA use MTX and/or biologic therapy in accordance with the treat-to-target concept. Serum cytokine concentrations were determined using the xMAP multiplexing technology baseline, 3 and 6 months after the start of therapy. US with grey scale (GS), power Doppler (PD) and destructive changes (erosion), according to the criteria of OMERACT, were performed baseline, 3, 6, 9 and 12 months after the start of therapy. We analysed absolutely levels and theirs changes(Δ). X-ray examination was conducted baseline and at 12 month of therapy with an assessment of X-ray changes by Sharp van der Heijde scores (ΔSHS). <h3>Results</h3> Levels of proinflammatory cytokines (IL1β, IL6, IL12, IL15, TNFα) decreased by 3 month. Significant differences in PD-group at the end of observation were revealed only for IL6 and TNFα, and with X-ray progression – for Δ IL17 level at 6 month. At baseline a positive correlation was found between PD and levels of IL1β (r=0.34), IL6 (r=0.42). We found correlation between PD at 12 month and ΔIL1β by 6 month, ΔTNFα by 3 month. In the PD-group concentration of IL6 baseline was significantly higher: 75.2 (37.9; 101.7) vs 38.7 (19.2; 59.6); by 6 month level of TNFα in this group also higher: 67.6 (34.3;125.5) vs 38.8 (21.9; 67.2). Radiographic progression was detected in 6 of 35 RA patients; this group was with PD and destructive change by US was significantly higher. We found correlation between ΔIL17 and ΔFGF levels at 3 month with PD at 3 month: r=0.57 p=0.001 and r=0.52 p=0.004, respectively. Also we found significantly correlation between ΔIL17 and ΔFGF at 3 month and ΔIL17 at 6 month with the X-ray examination: the sum of erosions, the sum of the narrowing of the joints and the total score (for IL17 at 3 month r=0.43 p=0.01, r=0.51 p=0.0018, r=0.52 p=0.001, respectively, for the FGF at the 3 month r=0.37 p=0.03, r=0.41 p=0.014, r=0.41 p=0.014, respectively, for IL17 at 6 month r=0.38 p=0.024, r=0.39 p=0.019, r=0.4 p=0.016, respectively). <h3>Conclusions</h3> The revealed relationship of active synovitis by US, X-ray progression and biomarkers of inflammation in RA confirm the role of ultrasound as a method of independent evaluation of the course and outcomes of the disease. <h3>Disclosure of Interest</h3> None declared
SP0145 Light at the lower gastrointestinal tract in systemic sclerosis
Authors: C.P. Denton
Journal: Annals of the Rheumatic Diseases (2018)

Gastrointestinal tract manifestations of systemic sclerosis are common and represent a high burden of the disease. Whilst some aspects can be treated the lower bowel involvement is especially challenging. The midgut is affected with dysmotility and functional impairment including the consequences of impaired absorption and exocrine pancreatic insufficiency. Midgut hypomotility can lead to stagnation of bowel contents and small intestinal bacterial overgrowth that contributes to bloating, diarrhoea and malnutrition. Colonic involvement contributes to chronic constipation and anorectal disease is a major non-lethal burden leading to incontinence. This has enormous impact on quality of life. The end result is a constellation of symptoms and clinical problems that require integrated management to ensure appropriate investigation and treatment. Strategies that can be helpful include broad spectrum antibiotics to address small intestinal bacterial overgrowth and prokinetics to address issues of pseudo-obstruction. The latter is best managed conservatively. Occasionally patients develop nutritional failure that requires parental nutrition. This can be successfully delivered as part of a home care programme and is generally parenteral supplementation, for example with overnight feeds, rather than total parenteral nutrition. Constipation and diarrhoea require opposite strategies for treatment and often a high degree of patient self-management. Recent trials of techniques to improve anorectal incontinence have been promising for strategies such as posterior tibial nerve stimulations and this may represent useful option in some cases. <h3>Disclosure of Interest</h3> C. Denton Grant/research support from: Inventiva, CSL Behring, GSK, Bayer, Consultant for: GSK, Actelion, Inventiva, Roche, Bayer, Boehringer Ingelheim, EMD Serono, Sanofi Aventis
The effect of local anesthetic continuous wound infusion for the prevention of postoperative pneumonia after on-pump cardiac surgery with sternotomy: the STERNOCAT randomized clinical trial
Authors: Julien Amour, Bernard Cholley, Alexandre Ouattara, Dan Longrois, Pascal Leprince, Jean-Luc Fellahi, Bruno Riou, Sarah Hariri, Christian Latrémouille, Alain Rémy, Sophie Provenchère, Aude Carillion, Paul Achouh, Louis Labrousse, Alexy Tran Dinh, Nora Ait Hamou, Ahmed Charfeddine, Alexandre Lafourcade, David Hajage, Adrien Bouglé, Louis Puybasset, Dimitri Margetis, Guillaume Lebreton, Mojgane Laalie, Théodoro Barreda, Cossimo D’Alessandro, Marie-Fazia Boughenou, Alain Bel, Jérôme Jouan, Leonara Du Puy Montbrun, Philippe Menasché, Astrid Quessard
Journal: Intensive Care Medicine (2019)
Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion
Authors: Taito Matsuda, Takashi Irie, Shutaro Katsurabayashi, Yoshinori Hayashi, Tatsuya Nagai, Nobuhiko Hamazaki, Aliya Mari D. Adefuin, Fumihito Miura, Takashi Ito, Hiroshi Kimura, Katsuhiko Shirahige, Tadayuki Takeda, Katsunori Iwasaki, Takuya Imamura, Kinichi Nakashima
Journal: Neuron (2019)
Challenges in assessing the efficacy of systemic corticosteroids for severe wheezing episodes in preschool children
Authors: Theresa W. Guilbert, Leonard B. Bacharier, David T. Mauger, Wanda Phipatanakul, Stanley J. Szefler, Susan Boehmer, Avraham Beigelman, Anne M. Fitzpatrick, Daniel J. Jackson, Sachin N. Baxi, Mindy Benson, Carey-Ann D. Burnham, Michael D. Cabana, Mario Castro, James F. Chmiel, Ronina Covar, Michael Daines, Jonathan M. Gaffin, Deborah A. Gentile, Fernando Holguin, Elliot Israel, H. William Kelly, Stephen C. Lazarus, Robert F. Lemanske, Ngoc Ly, Kelley Meade, Wayne Morgan, James Moy, J. Tod Olin, Stephen P. Peters, Jacqueline A. Pongracic, Hengameh H. Raissy, Kristie Ross, William J. Sheehan, Christine Sorkness, W. Gerald Teague, Shannon Thyne, Fernando D. Martinez, Lisa Bartnikas, Alisha Bouzaher, Christopher Burke, Matthew Cavanaugh, Julia Chen, Elizabeth Cunningham, Amparito Cunningham, James Friedlander, Enal Hindi, David Kantor, Perdita Permaul, Devako Rao, Melinda Rossi, Doris Schierembergg, Kynda Schneider, Jennifer Troung, Dale Umetsu, Joseph Zhou, Jill Chmielewski, Anna Fishbein, Iliana Flexas, Ramsay Fuleihan, Rajesh Kumar, James Lane, Melanie Makhija, Louis Martos, Brandon Parker, Benjamin Prince, Nashmia Qamar, Mary Riordan, Rachel Robinson, Waheeda Samady, Christine Szychlinski, Daniel Tsang, Christopher Codispoti, Juan Fu, Grace Li, Diana Munoz-Mendoza, Benjamin Thompson, Melanie Gleason, Sakari Graves, Jonathan Malka, Melanie Phillips, Gayle Spears, D. Sundstrom, Michael White, Christina Batson, Lea Davies, Franceska Kelly, Esmeralda Morales, Abby Redway, Mary Spicher, Lauren Kaminski, Megan R. Knutson, Kelly Miller, Jennifer Promer, Sheila Turcsanyi, Tanya Watson, Shean Aujla, John Broyles, Hey Chong, Patricia Dubin, Jonathan Finder, Todd D. Green, Lori Holt, Adam Kufen, Geoffrey Kurland, Rose Lanzo, David Nash, Julianne Parente, Catherine Smith, Jonathan Spahr, Daniel J. Weiner, Daniel Craven, Danielle Goetz, Meeghan Hart, Leigh A. Kerns, Laurie Logan, Ross Myers, Laura Veri, Erica Butler, Jennifer Maiolo, Sara Misplay, David Skoner, Glennys Smith, Wanda Caldwell, Courtney Dula, Alysa Ellis, Caroline Horner, Lila Kertz, Tina Norris, Katherine Rivera-Spoljaric, Oscar Rodriguez, Robert Strunk, Jessica Bowman, Vicky Bowyer, Judy Gonzales-Vargas, Sara Hawkey, Susannah McCormick, Michelle McKean, Dan Shapiro, Katherine Tom, Jason Decker, Keonna Harrison, Dayna Long, Jyothi Marbin, Robert Mok, Cindy Nelson-Purdy, Dennis Ren, Hollie Stessel, Jason Decker, Keonna Harrison, Dayna Long, Jyothi Marbin, Robert Mok, Cindy Nelson-Purdy, Dennis Ren, Hollie Stessel, Deb Green, Denise Thompson-Batt, Kristin Wavell, Donna Wolf, Timothy Beaty, Alice C. Bruce, Karen DeMuth, Jennifer Dodds, Shaneka Douglas, Dawn M. Simon, Denise Whitlock, Shanae Brown, Susan Boehmer, Matthew Bowman, Loretta Doty, Linda Ferrari, Beth Gern, Dave Mauger, Aimee Merchlinski, James Schmidt, Daniel Tekely, Lindsay Texter, Angela Updegrave, Ronald Zimmerman
Journal: Journal of Allergy and Clinical Immunology (2019)
Abstract 13062: Pathogenic IgG Antibodies in Hyperlipidemic Mice Promote Atherosclerosis
Authors: Tin Kyaw, Chris Tay, Peter Kanellakis, Anh Cao, Peter Tipping, Ban-Hock Toh, Alex Bobik
Journal: Circulation (2016)

Background: B2 cells promote atherosclerosis, but the exact mechanisms by which they promote atherosclerosis are not known. Antibodies can be pathogenic in a number of chronic inflammatory diseases. Here, we examined the role of antibodies in the development of atherosclerosis in hyperlipidemic mice. Methods and Results: As an interaction between B cells and CD4 T cells is important for plasma cell development and antibody production, we generated mixed chimeric LDLR -/- mice with B cells selectively deficient in MHC II or CD40 molecules. B cells deficient in either molecule decreased atherosclerosis by ~30-40%. This was associated with reduced spleen germinal centre B cells and plasma cells, markedly reduced plasma total immunoglobulins, reduced spleen CD4 T cell activation and decreased IFN-γ+ CD4 T cells. To confirm that the observed effects on atherosclerosis were largely due to impaired plasma cell generation and antibody production, we also deleted B cell-specific Blimp-1, a transcription factor critically important for B cell differentiation into antibody-producing plasma cells. Chimeric LDLR -/- mice transplanted with CD23 CRE -Blimp-1 fl/fl bone marrow were completely devoid of spleen plasma cells and plasma total immunoglobulins but CD4+ T cell activation was unaffected; atherosclerosis in these mice was reduced by nearly 50%. To exclude the possibility that the reduction in atherosclerosis was due to deletion of plasma cells, we then purified IgG from hyperlipidemic mice with atherosclerosis and transferred the IgG into immunoglobulin/plasma cell-deficient CD23 CRE -Blimp-1 fl/fl bone marrow transplanted LDLR -/- mice. Atherosclerotic lesions doubled in size in mice that received IgG from atherosclerotic mice, compared to transfer of IgG purified from non-atherosclerotic mice. Conclusions: Our study indicates that IgG antibodies generated in hyperlipidemic mice during atherosclerosis development accelerates growth of atherosclerotic lesions. Targeting pathogenic IgG antibodies in atherosclerosis has a potential to reduce lesion progression and the incidence of heart attacks and strokes.
Cyclical Sweating Caused by Temporal Lobe Seizures
Authors: Mark K. Chelmowski, George L. Morris
Journal: Annals of Internal Medicine (2019)

Letters4 June 2019Cyclical Sweating Caused by Temporal Lobe SeizuresMark K. Chelmowski, MD and George L. Morris III, MDMark K. Chelmowski, MDAdvocate Aurora Health Care, Milwaukee, Wisconsin (M.K.C.) and George L. Morris III, MDWisconsin Ascension Health Care, Milwaukee, Wisconsin (G.L.M.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L18-0425 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Excessive sweating is commonly reported by patients in primary care. Obesity, anxiety, hyperthyroidism, infection, cancer, and side effects of some medications are the most frequent causes. Cyclical sweating is different because it occurs in regularly repeated cycles.Objective: To alert clinicians to an uncommon cause of excessive sweating.Case Report: A 60-year-old man had spontaneous episodes of sweating that had started 3 years earlier. He was otherwise healthy; worked as a business consultant; and was in a long-term, monogamous, same-sex relationship. He and his partner had meticulously chronicled the episodes, which occurred approximately monthly in clusters. Every 24 to ...References1. Moseley B, Bateman L, Millichap JJ, Wirrell E, Panayiotopoulos CP. Autonomic epileptic seizures, autonomic effects of seizures, and SUDEP. Epilepsy Behav. 2013;26:375-85. [PMID: 23099286] doi:10.1016/j.yebeh.2012.08.0201 CrossrefMedlineGoogle Scholar2. Gowers WR. The Borderland of Epilepsy: Faints, Vagal Attacks, Vertigo, Migraine, Sleep Symptoms, and Their Treatment. Philadelphia: P Blakiston's Son; 1903. Google Scholar3. Werz MA. Temporal lobe epilepsy. In: Gowers WR, Pita I, eds. Epilepsy Syndromes. Philadelphia: Saunders Elsevier; 2010:73-89. Google Scholar4. Stefan H, Pauli E, Kerling F, Schwarz A, Koebnick C. Autonomic auras: left hemispheric predominance of epileptic generators of cold shivers and goose bumps? Epilepsia. 2002;43:41-5. [PMID: 11879385] CrossrefMedlineGoogle Scholar5. Baud MO, Kleen JK, Mirro EA, Andrechak JC, King-Stephens D, Chang EF, et al. Multi-day rhythms modulate seizure risk in epilepsy. Nat Commun. 2018;9:88. [PMID: 29311566] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Advocate Aurora Health Care, Milwaukee, Wisconsin (M.K.C.)Wisconsin Ascension Health Care, Milwaukee, Wisconsin (G.L.M.)Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L18-0425.This article was published at Annals.org on 15 January 2019. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 4 June 2019Volume 170, Issue 11Page: 813-814KeywordsElectroencephalographyEmotionsEpilepsyEpileptic seizuresSweatTemporal lobeVertigoVital signsVomitingWeight loss ePublished: 15 January 2019 Issue Published: 4 June 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Use of Bisphosphonates in Elderly Patients With Newly Diagnosed Multiple Myeloma
Authors: Siyang Leng, Yizhen Chen, Wei-Yann Tsai, Divaya Bhutani, Grace C. Hillyer, Emerson Lim, Melissa K. Accordino, Jason D. Wright, Dawn L. Hershman, Suzanne Lentzsch, Alfred I. Neugut
Journal: Journal of the National Comprehensive Cancer Network (2019)

Bisphosphonates reduce skeletal-related events (SREs) in patients with multiple myeloma (MM) and, in some studies, improved survival. Since 2011, bisphosphonate use has been recommended by NCCN for all patients with newly diagnosed MM receiving antineoplastic therapy independent of the presence of bone disease. This study investigated their use after these guidelines were established.