tbuckley/cabot-search huggingface dataset:
Northstar-3: Interim Results from a Phase 3 Study Evaluating Lentiglobin Gene Therapy in Patients with Transfusion-Dependent β-Thalassemia and Either a β0 or IVS-I-110 Mutation at Both Alleles of the HBB Gene
Authors: Ashutosh Lal, Franco Locatelli, Janet L. Kwiatkowski, Andreas E. Kulozik, Evangelia Yannaki, John B. Porter, Isabelle Thuret, Martin G. Sauer, Heidi Elliot, Ying Chen, Richard A. Colvin, Alexis A. Thompson
Journal: Blood (2019)
ATIM-35. THE ASSOCIATIONS BETWEEN TOTAL LYMPHOCYTE COUNTS AFTER CONCOMITANT CHEMORADIATION WITH OVERALL SURVIVAL IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA
Authors: Stephen Ahn, Jae-Sung Park, Yong Kil Hong, Seung Ho Yang, Sin-Soo Jeun
Journal: Neuro-Oncology (2019)

Abstract Several studies have been conducted to determine the relationship between post-treatment total lymphocyte count (TLC) and overall survival (OS) in patients with malignant tumors including glioblastomas (GBMs). In this retrospective study, whether patients with newly diagnosed GBM experience significant lymphopenia after concomitant chemoradiation (CCRT) was evaluated, and whether TLC after this treatment is associated with OS in the treated population was examined. Using electronic medical records, all patients newly diagnosed with GBM between 2008 and 2016 at Seoul St. Mary’s Hospital were retrospectively examined. The eligible criteria included the following: 1) craniotomy with surgical resection or biopsy, 2) completion of CCRT, 3) accessible baseline and/or follow-up complete blood count (CBC). Median TLC significantly decreased after completion of CCRT, compared to TLC at baseline (1,742 versus 1,319 cells/mm3, P-value &amp;lt; 0.001). Patients with TLC &amp;lt; 1,200 cells/mm3 at 4 weeks after the completion of CCRT showed shorter survival than those with TLC ≥ 1,200 cells/mm3 with median OS of 14.5 versus 21.0 months (P-value = 0.017). Also, in multivariate analysis for OS, TLC &amp;lt; 1,200 cells/mm3 at 4 weeks after the completion of CCRT (HR 1.97, 95% CI 1.61 – 2.25, P-value = 0.004) were significantly associated with shorter survival. The results from the present study indicate that treatment-related total lymphocyte counts after CCRT is associated with worse survival in patients with newly diagnosed GBM.
Assessment of carotid compliance using real time vascular ultrasound image analysis in Marfan syndrome
Authors: Anatoli Kiotsekoglou, Valentine Newey, Abhay Bajpai, Bart Bijnens, Benedict Kapetanakis, Alison Halliday, Dariush Nassiri, John Camm, George Sutherland, Anne Child
Journal: Circulation (2007)
Lack of social care has cost the NHS 2.5 million bed days since last election, charity says
Authors: Gareth Iacobucci
Journal: BMJ (2019)

A lack of social care provision will have led to 2.5 million lost bed days in the NHS between the last UK general election and this one, an analysis by the charity Age UK has found.

Over the course of 917 days from 8 June 2017 (the date of the last general election) and 12 December 2019, delayed discharges from hospital to social care in the community will have cost the NHS £587m (€695m; $770m), the charity estimates.

Delayed or lost bed days are defined as each day a person spends unnecessarily in hospital when they are medically fit to be discharged.

The charity said …
Differences in colon cancer incidence rates by latitude.
Authors: Binay Kumar Shah, Krishna Bilas Ghimire, Barsha Nepal
Journal: Journal of Clinical Oncology (2013)

e14627 Background: There is significant decrease in the ultraviolet B photons reaching the earth’s surface during November to February (Holick MF Am J Clin Nutr. 2004 Dec; 80(6 Suppl):1678S-88S). This results in little if any vitamin D3 production in the skin during this period. This study was conducted to evaluate difference in colon cancer age adjusted incidence rates in the northern (latitude ≥37 o N) and the southern (latitude &lt; 37 o N) regions in the contiguous United States during 1973-2008. Methods: Patients, aged 20 years and older, who had been diagnosed with colong cancer during January 1973 and December 2008, were selected from the Surveillance, Epidemiology, and End Results (SEER) 13 database. Based on the counties’ centroid, northern (latitude ≥37 o N) and southern (latitude &lt; 37 o N) regions were determined. We compared age adjusted incidence rates (AAIR) of colon cancer in the southern and northern regions among cohorts of patients categorized by age (≥20, 20-64, ≥65 years), gender (Men, Women) and Race (Caucasians, Blacks, Others). The AAIR was calculated per 100,000 population. We used SEER*Stat software to calculate age adjusted incidence rate, incidence ratio, confidence interval (CI, 95%) and P value. Results: There were 314,975 cases of colon cancer diagnosed among 608,245,557 US population during 1973-2008. The overall colon cancer AAIR was 57.1 per 100,000 population studied. The incidence rates were 49.1 in the south and 58.7 in the north of 37 o N latitude, (95% CI 1.18-1.20, p&lt;0.05). The AAIRs for patients in the age group 20-64 years were 17.9 and 18.8 in the southern and northern regions, (CI 95%, 1.0346-1.0697), p&lt;0.0005 respectively. The incidence rates for patients aged ≥65 years were 194.3 and 243.9 in the southern and northern regions, (CI 95%, 1.0346-1.0697) p&lt;0.0005. Similarly, the AAIRs were significantly higher in the northern region compared to southern region for both sexes and all ethnic groups. Conclusions: Colon cancer age-adjusted incidence rate is significantly higher in the Northern compared to the Southern region of the US. The higher incidence of colon cancer in the North may be related to lack of sunlight exposure and relative vitamin D deficiency.
Blood pressure variations to be considered in the treatment of hypertension.
Authors: Tadanao Takeda, Keisuke Nishiyama, Yasunobu Hirata
Journal: Circulation (1981)

Diurnal variations of the basal blood pressure in patients with essential hypertension were investigated by the indirect recording methods. To estimate the reduction in blood pressure at midnight, disturbance of sleep in the patients should be considered. Relationship between neurohumoral factors and the diurnal blood pressure variations were also evaluated. 1) Variations of the casual blood pressure at the clinic visits may be stabilized beyond 15 minutes of the sitting rest. 2) During the out-patient treatment of essential hypertension with placebo for 6 weeks, 16% of the patients showed reduction in mean arterial pressure of 13 mmHg or more. 3) Significant influence of seasons on blood pressure was not apparent for 6 weeks of the placebo treatment of hypertension. But in patients under the long-term antihypertensive treatment, blood pressure in summer was maintained significantly lower than in winter. 4) Self-monitoring of blood pressure by patients at home is valuable for estimating diurnal changes of blood pressure with the antihypertensive treatment.
Timeliness of infectious disease reporting, the Netherlands, 2003 to 2017: law change reduced reporting delay, disease identification delay is next
Authors: Corien M Swaan, Albert Wong, Axel Bonačić Marinović, Mirjam EE Kretzschmar, Jim E van Steenbergen
Journal: Eurosurveillance (2019)

Background Timely notification of infectious diseases is essential for effective disease control and needs regular evaluation. Aim Our objective was to evaluate the effects that statutory adjustments in the Netherlands in 2008 and raising awareness during outbreaks had on notification timeliness. Methods In a retrospective analyses of routine surveillance data obtained between July 2003 and November 2017, delays between disease onset and laboratory confirmation (disease identification delay), between laboratory confirmation and notification to Municipal Health Services (notification delay) and between notification and reporting to the National Institute for Public Health and the Environment (reporting delay) were analysed for 28 notifiable diseases. Delays before (period 1) and after the law change (periods 2 and 3) were compared with legal timeframes. We studied the effect of outbreak awareness in 10 outbreaks and the effect of specific guidance messages on disease identification delay for two diseases. Results We included 144,066 notifications. Average notification delay decreased from 1.4 to 0.4 days across the three periods (six diseases; p &lt; 0.05), reporting delay decreased mainly in period 2 (from 0.5 to 0.1 days, six diseases; p &lt; 0.05). In 2016–2017, legal timeframes were met overall. Awareness resulted in decreased disease identification delay for three diseases: measles and rubella (outbreaks) and psittacosis (specific guidance messages). Conclusions Legal adjustments decreased notification and reporting delays, increased awareness reduced identification delays. As disease identification delay dominates the notification chain, insight in patient, doctor and laboratory delay is necessary to further improve timeliness and monitor the impact of control measures during outbreaks.
Evolution of a Novel and Adaptive Floral Scent in Wild Tobacco
Authors: Han Guo, Nathalie D Lackus, Tobias G Köllner, Ran Li, Julia Bing, Yangzi Wang, Ian T Baldwin, Shuqing Xu
Journal: Molecular Biology and Evolution (2019)

Many plants emit diverse floral scents that mediate plant-environment interactions and attain reproductive success. However, how plants evolve novel and adaptive biosynthetic pathways for floral volatiles remains unclear. Here, we show that in the wild tobacco, Nicotiana attenuata, a dominant species-specific floral volatile (benzyl acetone, BA) that attracts pollinators and deters florivore is synthesized by phenylalanine ammonia-lyase 4 (NaPAL4), isoflavone reductase 3 (NaIFR3), and chalcone synthase 3 (NaCHAL3). Transient expression of NaFIR3 alone in N. attenuata leaves is sufficient and necessary for ectopic foliar BA emissions, and coexpressing NaIFR3 with NaPAL4 and NaCHAL3 increased the BA emission levels. Independent changes in transcription of NaPAL4 and NaCHAL3 contributed to intraspecific variations of floral BA emission. However, among species, the gain of expression of NaIFR3 resulted in the biosynthesis of BA, which was only found in N. attenuata. This study suggests that novel metabolic pathways associated with adaptation can arise via reconfigurations of gene expression.
High performance one-for-all phototheranostics: NIR-II fluorescence imaging guided mitochondria-targeting phototherapy with a single-dose injection and 808 nm laser irradiation
Authors: Qi Wang, Jingzeng Xu, Renyong Geng, Jie Cai, Jie Li, Chen Xie, Weihua Tang, Qingming Shen, Wei Huang, Quli Fan
Journal: Biomaterials (2019)
Loss of Endothelial FTO Antagonizes Obesity-Induced Metabolic and Vascular Dysfunction
Authors: Nenja Krüger, Lauren A. Biwer, Miranda E. Good, Claire A. Ruddiman, Abigail G. Wolpe, Leon J. DeLalio, Sara Murphy, Edgar H. Macal, Louis Ragolia, Vlad Serbulea, Angela K. Best, Norbert Leitinger, Thurl E. Harris, Swapnil K. Sonkusare, Axel Gödecke, Brant E. Isakson
Journal: Circulation Research (2019)

Increasing prevalence of obesity and its associated risk with cardiovascular diseases demands a better understanding of the contribution of different cell types within this complex disease for developing new treatment options. Previous studies could prove a fundamental role of FTO (fat mass and obesity-associated protein) within obesity; however, its functional role within different cell types is less understood.We identify endothelial FTO as a previously unknown central regulator of both obesity-induced metabolic and vascular alterations.We generated endothelial Fto-deficient mice and analyzed the impact of obesity on those mice. While the loss of endothelial FTO did not influence the development of obesity and dyslipidemia, it protected mice from high-fat diet-induced glucose intolerance and insulin resistance by increasing AKT (protein kinase B) phosphorylation in endothelial cells and skeletal muscle. Furthermore, loss of endothelial FTO prevented the development of obesity-induced hypertension by preserving myogenic tone in resistance arteries. In Fto-deficient arteries, microarray analysis identified upregulation of L-Pgds with significant increases in prostaglandin D2 levels. Blockade of prostaglandin D2 synthesis inhibited the myogenic tone protection in resistance arteries of endothelial Fto-deficient mice on high-fat diet; conversely, direct addition of prostaglandin D2 rescued myogenic tone in high-fat diet-fed control mice. Myogenic tone was increased in obese human arteries with FTO inhibitors or prostaglandin D2 application.These data identify endothelial FTO as a previously unknown regulator in the development of obesity-induced metabolic and vascular changes, which is independent of its known function in regulation of obesity.
NLRP3-associated autoinflammatory diseases: Phenotypic and molecular characteristics of germline versus somatic mutations
Authors: Camille Louvrier, Eman Assrawi, Elma El Khouri, Isabelle Melki, Bruno Copin, Emmanuelle Bourrat, Noémie Lachaume, Bérengère Cador-Rousseau, Philippe Duquesnoy, William Piterboth, Fawaz Awad, Claire Jumeau, Marie Legendre, Gilles Grateau, Sophie Georgin-Lavialle, Sonia A. Karabina, Serge Amselem, Irina Giurgea
Journal: Journal of Allergy and Clinical Immunology (2019)
Bortezomib Plus Dexamethasone as Second Line Therapy after Vincristine, Adriamycin and Dexamethasone in Multiple Myeloma
Authors: Pilar Galera, Ricarda Garcia-Sanchez, Ma. Angeles Cuesta, Manuel Almagro, Eduardo Ríos, Ma. Soledad Duran, Alicia Sanchez, Maria Casanova, Manuel Barrios, Laura Entrena, Pedro Gonzalez, Beatriz Dominguez, Ma. Angeles Medina, Ildefonso Espigado, Paula Cerezuela, Juan Antonio López, Carlos Clavero, Gemma Ramirez, Manuel Jurado, Encarnación Gil, Antonio Alcala, Antonio Gracia, Ana Isabel Heiniger
Journal: Blood (2008)
A self-doping conductive polymer hydrogel that can restore electrical impulse propagation at myocardial infarct to prevent cardiac arrhythmia and preserve ventricular function
Authors: Chongyu Zhang, Meng-Hsuan Hsieh, Song-Yi Wu, Shu-Hong Li, Jun Wu, Shi-Ming Liu, Hao-Ji Wei, Richard D. Weisel, Hsing-Wen Sung, Ren-Ke Li
Journal: Biomaterials (2019)
Procalcitonin Is Useful for Evaluating Patients with Ambiguous Presentation and for Early Discontinuation of Antibiotics in Community-acquired Pneumonia
Authors: Philipp Schuetz
Journal: American Journal of Respiratory and Critical Care Medicine (2019)

Thoracic Society (ATS) and Infectious Diseases Society of America (IDSA) (1).It has been 12 years since the last ATS/IDSA CAP guidelines were updated, and clinicians have been anxiously waiting for more recent guidance to assist them in the management of patients presenting with this common and challenging infectious syndrome (2).The new CPG were produced by a multidisciplinary panel of 15 experts from Australia, Canada, and the United States, and incorporate new and relevant research published since 2007 (1).Although the new CPG were endorsed by the Society of Infectious Diseases Pharmacists, and the National Academy of Medicine recommended that guideline development committees should be composed of experts from a variety of disciplinary backgrounds, there was no pharmacist representation among the authors (1, 3).This is not the first time major CPGs that include numerous pharmacotherapy recommendations have been released without inclusion of a pharmacist on the authorship panel.In fact, the proportion of pharmacist authorship in national CPG published between 2010 and 2016 was 31% and the proportion of pharmacist authorship in current IDSA guidelines was 21% (4, 5).These numbers, albeit low, represent an improvement from the past, when the pharmacist authorship representation in retired IDSA guidelines was only 13% (5).Calls to include pharmacists as authors on CPG are not new (6).Pharmacists are well trained in pharmacotherapy, pharmacokinetics, and pharmacodynamics (7).Many pharmacists complete accredited Postgraduate Year One general and Postgraduate Year Two infectious diseases specialty residencies and become board certified in infectious diseases pharmacy (8-10).Pharmacists offer a unique perspective on designing and monitoring antimicrobial regimens and play a leading role in antimicrobial stewardship (11).We call on the ATS and IDSA to further collaborate with pharmacy organizations and to demonstrate their commitment to inclusion by inviting a pharmacist to serve as an author on the next CAP guidelines.
DNA Repair Gene, XRCC1 Polymorphisms Are Associated with Chemotherapy Induced Toxicity in Patients with Diffuse Large B Cell Lymphoma Who Received Frontline R-CHOP Chemotherapy.
Authors: In-Suk Kim, Gyeong-Won Lee, Hoon-Gu Kim, Sun-Young Kong, HyeonSeok Eom
Journal: Blood (2008)
EPOCH-F: A Novel Salvage Regimen for Multiple Myeloma Prior to Reduced-Intensity Allogeneic Stem Cell Transplantation
Authors: Saad Jamshed, Daniel Fowler, Sattva Neelapu, Robert M. Dean, Seth M Steinberg, Jeanne Odom, Kelly Snow, Ronald E Gress, Michael R Bishop
Journal: Blood (2008)
Selective decontamination of the digestive tract (SDD) in critically ill patients: a narrative review
Authors: Bastiaan H. J. Wittekamp, Evelien A. N. Oostdijk, Brian H. Cuthbertson, Christian Brun-Buisson, Marc J. M. Bonten
Journal: Intensive Care Medicine (2019)

Selective decontamination of the digestive tract (SDD) is an infection prevention measure for intensive care unit (ICU) patients that was proposed more than 30 years ago, and that is currently considered standard of care in the Netherlands, but only used sporadically in ICUs in other countries. In this narrative review, we first describe the rationale of the individual components of SDD and then review the evidence base for patient-centered outcomes, where we distinguish ICUs with low prevalence of antibiotic resistance from ICUs with moderate–high prevalence of resistance. In settings with low prevalence of antibiotic resistance, SDD has been associated with improved patient outcome in three cluster-randomized studies. These benefits were not confirmed in a large international cluster-randomized study in settings with moderate-to-high prevalence of antibiotic resistance. There is no evidence that SDD increases antibiotic resistance. We end with future directions for research.
IMMUNOHISTOLOGIC FINDINGS IN THE GLOMERULAR CRESCENTS IN VARIOUS RENAL DISEASES
Authors: Takao Nagai, Tadao Tamura, Chuichi Kawai
Journal: Circulation (1979)

Renal tissues from 37 patients with glomerulopathies involving glomerular crescents were investigated using an immunofluorescence technique. Immunohistologic findings revealed two kinds of crescents, those with fibrinogen deposits (active), and those without (inactive). The degree of IgG deposition in glomeruli with active crescents was much higher than in glomeruli with inactive crescents in acute glomerulonephritis (AGN) and chronic glomerulonephritis (CGN). Active crescents were observed only in biopsy specimens taken within three months after the onset of acute glomerulonephritis or the acute exacerbation of chronic glomerulonephritis. These findings suggest that in AGN and CGN active crescents occur in an earlier stage of glomerular lesions and a more active stage in the immunological process than inactive crescents. The significance of active crescents in SLE, diabetic nephropathy and nephropathy associated with rheumatic arthritis was not evaluated due to the small number of patients.
Tuberculosis: experts question evidence and safety data used to approve latest drug
Authors: Vidya Krishnan
Journal: BMJ (2019)

Two dozen leading tuberculosis (TB) clinicians and researchers have written to a leading TB charity to question the US’s approval of the antibiotic pretomanid, which was hailed by trialists three months ago as a “watershed” moment.

In August the United States Food and Drug Administration approved pretomanid, the third new anti-TB drug in over 40 years.1 Pretomanid is used alongside bedaquiline and high dose linezolid in the “BPaL regimen,” which is also called Nix-TB when this combination is used for six months.

Francesca Conradie, principal investigator of the trial that supported pretomanid’s application, greeted the announcement by saying that treatment of TB would be measured as before and after pretomanid, much as “the annals of time are measured before and after Christ.”2

Pretomanid was announced as a fast acting oral therapy that improved the success rates of removing drug resistant TB from the sputum of patients after six months from 34% to 89%, citing data submitted to the FDA from the Nix-TB trial.3

The Global Alliance for TB Drug Development (TB Alliance), the not-for-profit innovator of the drug, said that it would haul medieval and toxic treatment of …
Therapeutic Plasma Levels of OKT3 Muromonab Are Effective as Second-Line and Subsequent Treatment in Recipients of Stem Cell Allografts with Steroid-Resistant Acute Graft-Versus-Host Disease.
Authors: Stefan Knop, Holger Hebart, Heidi Gscheidle, Ernst Holler, Hans J. Kolb, Dietger W. Niederwieser, Hermann Einsele
Journal: Blood (2004)
Abstract 16096: Anti-Oxidant Treatment in Fructose-Induced Salt-Sensitive Model of Hypertension Reverses Remodelling of the Left Ventricle
Authors: Dragana Komnenov, Natalia Perecki, Peter Levanovich, Noreen Rossi
Journal: Circulation (2018)

Dietary supplementation with 20% fructose in rats leads to salt-sensitive hypertension within three weeks. We recently reported that at least part of the mechanism involves increases in renal sympa...
Determinants Of Tissue Iron Loading In Transfused and Non-Transfused β-Thalassemia and Sickle Cell Disease Patients – Biomarkers Of Iron Regulation and Inflammation
Authors: Zahra Pakbaz, Elizabeta Nemeth, Tomas Ganz, John B Porter, Patricia Evans, Kelsey M Houston, Roland Fischer, Marcela G Weyhmiller, Matt Herz, Bs, Jeffery L Miller, Robert Hagar, Lynne D Neumayr, Elliott Vichinsky, Paul Harmatz
Journal: Blood (2013)
Gene Expression Analysis of Follicular Lymphoma Provides a Potential Rationale for Histological Grading Revision.
Authors: Pier Paolo Piccaluga, Andrea Califano, Ulf Klein, Claudio Agostinelli, Beartiz Bellosillo, Eva Gimeno, Sergi Serrano, Francisco Solè, Yonghui Zang, Brunangelo Falini, Pier Luigi Zinzani, Stefano A. Pileri
Journal: Blood (2007)
Prognostication of Molecular Relapses after Dasatinib or Nilotinib Discontinuation in Chronic Myeloid Leukemia (CML): A FI-LMC STOP 2G-TKI Study Update
Authors: Delphine Rea, Franck E Nicolini, Michel Tulliez, Philippe Rousselot, Martine Gardembas, Gabriel Etienne, Francois Guilhot, Joelle Guilhot, Agnès Guerci, Martine Escoffre-Barbe, Laurence Legros, Bruno Villemagne, Gaëlle Guillerm, Marie-Pierre Noel, Valerie Coiteux, Jean-Michel Pignon, Francois-Xavier Mahon
Journal: Blood (2019)
Correlating Multimodal Signals with Asthma Control in Children Using kHealth Personalized Digital Health System
Authors: Maninder Kalra, Amit Sheth, Samprit Banerjee, Utkarshani Jaimini, Dipesh Kadariya, V. Sridharan, K. Thirunarayam, R. Venkataramanan, Hong Yung Yip
Journal: American Journal of Respiratory and Critical Care Medicine (2018)
Evaluation of Three Different Cyclosporine-Based Graft Versus Host Disease (GVHD) Prophylaxis Regimens Following Nonmyeloablative Hematopoietic Stem Cell Transplantation (NST).
Authors: Ramaprasad Srinivasan, Nancy Geller, Sakti Chakrabarti, Igor Espinoza-Delgado, Teresa Donohue, Susan Leitman, Charles D. Bolan, Elizabeth J. Read, John A. Barrett, Richard W. Childs
Journal: Blood (2004)
Results of the First International Round Robin for the Quantification of Urinary and Plasma Hepcidin: Need for Standardization
Authors: Joyce JC Kroot, Erwin HJM Kemna, Sukhvinder Bansal, Mark Busbridge, Natascia Campostrini, Domenico Girelli, Robert C Hider, Vasiliki Koliaraki, Avgi Mamalaki, Gordana Olbina, Naohisa Tomosugi, Chris Tselepis, Douglas G Ward, Tomas Ganz, Jan CM Hendriks, Dorine W. Swinkels
Journal: Blood (2008)
Clinical Significance of Autoantibody Expression in Allogeneic Stem Cell Recipients.
Authors: Joon Ho Moon, Soo Jung Lee, Jong Gwang Kim, Yee Soo Chae, Shi Nae Kim, Yun Jeong Kim, Young Rok, Jang Soo Suh, Kun Soo Lee, Sang Kyun Sohn
Journal: Blood (2008)