tbuckley/cabot-search huggingface dataset:
AB0051 The influence of anti-inflammatory lipoxin a4 on generation of cytokines by pbmcs of patients with psoriatic arthritis
Authors: A.M. Lewandowska-Polak, M. Kubiak, O. Brzezinska, E. Pomorska, M.L. Kowalski, J. Makowska
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Psoriatic arthritis (PsA) is affecting up to 40% of the patients with psoriasis. The pathogenesis of PsA in not completely understood. One of the hypothesis suggest that repeated micro injuries and trauma and lack of proper inhibition of inflammation lead to chronic inflammation spreading to surrounding tissue and other joints and ligaments. One of the mediators which lead to inhibition of inflammation in healthy conditions are derivatives of arachidonic acid – lipoxins. <h3>Objectives</h3> The aim of the study was to assess if the influence of lipoxin A4 on inhibition of synthesis of pro-inflammatory cytokines by peripheral blood mononuclear cells (PBMNCs) of patients with psoriatic arthritis. <h3>Methods</h3> The study group consisted of 10 patients with psoriatic arthritis and 5 healthy controls. The peripheral blood mononuclear cells from patients with PsA and healthy controls were isolated and were stimulated with lipopolisacharide (LPS) with or without 200 nM of lipoxin A4 for 24 hours. The supernatants were collected after 24 hour stimulation. The levels of IL-1b, IFN-gamma, TNF alfa, MCP-1, IL-6, IL-8 and IL-33 were assessed by cytometric bead array system. <h3>Results</h3> Incubation of cells with LPS, increased production of all cytokines assessed either in patients with psoriatic arthritis or in healthy controls. In PBMCs from healthy controls incubation of cells with lipoxine A4 decrease production of proinflammatory cytokines (IL-1b, MCP-1, IL-8, IL-6, IL-33 and TNF-alfa; p<i>&lt;0,05</i>). However in patients with psoriatic arthritis addition of lipoxine A4 did not inhibit LPS – induced proinflammatory cytokines release (IL-1b, MCP-1, IL-6, IL-8, IL-33 and TNF-alfa, p<i>&lt;0,05</i>) <h3>Conclusions</h3> Our study demonstrated that modulation of Inflammation by lipid mediatiors in patients with psoriatic arthritis is dysregulated. <h3>Disclosure of Interest</h3> None declared
AB1242 Comparing adherence to treatment in lupus and vasculitis patients
Authors: E. Ntatsaki, B. Ali, S. Hamour, D. Isenberg, A.D. Salama
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Good adherence to prescribed pharmacotherapy is often over-estimated by physicians. Although in Systemic Lupus Erythematous (SLE) non-adherence is well-researched,<sup>1</sup> less research exists for vasculitis. <h3>Objectives</h3> We compared cohorts of patients with SLE and vasculitis to identify emerging patterns, behaviours and differences that could introduce barriers to adherence. <h3>Methods</h3> With patient input, we designed and undertook an anonymised questionnaire-based survey on the assessment of self-reported adherence and influencing factors in lupus and vasculitis clinics at University College Hospital (UCLH) and Royal Free Hospital (RFH). Both serve a largely urban and ethnically diverse population. <h3>Results</h3> A total of 199 patients completed the questionnaire. 110 (55%) had lupus and 75 (38%) vasculitis. 14 (7%) patients reported having other conditions and thus excluded. 52% were Caucasian and 37% were born outside the UK. The majority (78%) were female and 28% were aged &gt;60 years. Half were university graduates. Both centres had similar number of responses reducing bias. As shown in table 1, lupus patients were more females (p&lt;0.001), younger (p&lt;0.001), with longer disease duration (p&lt;0.001) and commented that adherence decreased with time (p=0.011) compared to vasculitis patients. Conversely, the vasculitis patients had higher attendance at clinic appointments (p=0.022) and were more confident they could manage taking tablets correctly. 67% of lupus patients and 81% of vasculitis patients reported that they always took tablets as prescribed (p=0.104). Concerns of weight gain and osteoporosis worried patients on steroids. Changes in weight, appearance, nausea and fatigue were common side-effects for missed medications. A small number of patients cited religion or alternative therapies as a reason (&lt;5%). Furthermore, as shown in fig 1, non-deliberate forgetfulness was the most common reason for non-adherence, in both groups. Overall, the majority of patients (96%) were self-medicating and reported taking an average of 5 different types of tablets, half of this for their Lupus/Vasculitis. Patients were well-informed about their condition and medications. <h3>Conclusions</h3> Self-reported adherence was high in our cohort with differences between the two groups. "Forgetfulness" regarding medication and keeping track of hospital appointments were the commonest reasons for non-adherence rather than deliberate non-adherence. Therefore novel behavioural or electronic cues for medication, including mobile app use, and appointment alerts could lead to improvement. Further work is required to identify whether a different personalised approach in the lupus and vasculitis patients can improve adhrence. <h3>Reference</h3> [1] Chambers SA, et al. Rheumatology. 2008;48: 266–271. <h3>Disclosure of Interest</h3> None declared
Comparison of Running Cutaneous Suture Spacing During Linear Wound Closures and the Effect on Wound Cosmesis of the Face and Neck
Authors: Lindsay R. Sklar, Aunna Pourang, April W. Armstrong, Simran K. Dhaliwal, Raja K. Sivamani, Daniel B. Eisen
Journal: JAMA Dermatology (2019)

Surgeons have varying opinions on the ideal cutaneous suture spacing for optimal cosmetic outcomes. To date, no studies concerning the effect of suture spacing on cosmetic outcomes exist in the literature.To compare outcomes and wound cosmesis achieved with running cutaneous sutures spaced 2 vs 5 mm apart.This randomized clinical trial was conducted at the University of California, Davis dermatology clinic from November 28, 2017, to June 15, 2018. Fifty-six patients 18 years or older with surgical fusiform wounds (from Mohs procedure or surgical excision) on the head or neck with assumed closure lengths of at least 3 cm were screened. Six patients were excluded, 50 patients were enrolled, and 48 patients were followed up.Fifty surgical fusiform wounds were randomized to running cuticular closure with 2-mm spacing on half and 5-mm spacing on half.At 3 months, patients and 2 masked observers evaluated each scar using the Patient and Observer Scar Assessment Scale (POSAS).A total of 50 patients (mean [SD] age, 71.1 [11.4] years; 43 [86%] male; 50 [100%] white) were enrolled in the study. The mean (SD) sum of the POSAS observer component scores was 10.7 (4.3) for the 2-mm interval side and 10.8 (3.5) for the 5-mm side at 3 months (P = .77). No statistically significant difference was found in the mean (SD) sum of the patient component for the POSAS score between the 2-mm interval side (10.2 [4.7]) and the 5-mm interval side (11.5 [6.4]) at 3 months (P = .24). No statistically significant difference was observed in mean (SD) scar width between the 2-mm side (0.9 [0.6] mm) and the 5-mm side (0.8 [0.4] mm; P = .15).No statistically significant difference in wound cosmesis or total complications were noted between running cuticular sutures spaced 2 vs 5 mm apart. Both suturing techniques resulted in similar cosmetic outcomes and complication rates. Surgeons may want to consider whether the extra time involved in placing very closely spaced cuticular sutures is worthwhile.ClinicalTrials.gov identifier: NCT03330041.
Abstract 16080: Right Ventricular Free Wall Strain Differentiates Acute Pulmonary Afterload Increases From Chronic Pulmonary Hypertension
Authors: Leah Wright, Kazuaki Negishi, Nathan Dwyer, Thomas Marwick
Journal: Circulation (2014)

Introduction: Distinction between an acute (pulmonary embolism (PE)) or chronic afterload etiology (pulmonary vascular disease (PHT)) of the right ventricle (RV) has important therapeutic implications. RV free wall strain (RVGS) may help to quantify this distinction. Hypothesis: RVGS can differentiate chronic from acute RV ventricular afterload. Methods: Study groups ; PE pts (n=45) with echo performed 48 h of CT pulmonary angiogram were compared with 1)PHT pts 1;1 matched for age, gender and pulmonary artery systolic pressure (PASP) (n=45), and 2) un-matched PHT control group (n=116). RVGS was assessed by speckle tracking. Diagnostic ability of RV measurements was assessed using receivers operating characteristic (ROC) curves in the matched pts, then incremental ability of RVGS was examined in un-matched pts. Multivariate logistic regression models were adjusted for age, sex, gender and PASP. Results: RVEDA, FAC, and RVGS were significantly impaired in PE pts (p<.05) with no significant differences in ot...
FRI0188 Factors associated with patient-physician discordance in global assessment in patients with axial spondyloarthritis: an asian perspective
Authors: C. Wang, W. Fong, Y.H. Kwan, J.K. Phang, N.L. Lui, Y.Y. Leung, J. Thumboo, P. Cheung
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Shared decision making between patients and physicians is important in the management of patients with axial spondyloarthritis. However patient's perspective on disease activity is not always similar to physician's perspective.<sup>1</sup> There are limited studies on patient-physician discordance, none of which is based on Asian population. <h3>Objectives</h3> To identify the factors associated with patient-physician discordance in patients with axial spondyloarthritis (axSpA) in an Asian population. <h3>Methods</h3> A cross-sectional study was conducted in 2 tertiary referral centres in Singapore. Patients who fulfilled ASAS 2009 criteria for axial spondyloarthritis (axSpA) were recruited. Sociodemographic, clinical, laboratory and patient reported outcomes (PROs) data were collected during study visits from 2014 to 2015. We performed univariate and multivariate logistics regression analysis to evaluate the factors associated with patient-physician discordance, which we defined as the absolute difference ≥20 mm between Patient Global Assessment (PGA) and Physician Global Assessment (PhGA). <h3>Results</h3> 298 axSpA patients were included: 82% male, 81% Chinese, median age of 40 (range:20–78) years, median disease duration of 9 (range:0.1–48) years. 80% were on non-steroidal anti-inflammatory drugs and 23% were on biologics. In univariate logistic regression analysis, current age (OR:1.01, p=0.09), post-secondary education level (OR:0.34, p=0.02), pain score (OR:1.03, p&lt;0.01), Bath Ankylosing Spondylitis Functional Index (BASFI) (OR:1.26, p&lt;0.01), Ankylosing Spondylitis Disease Activity Score C-reactive protein (ASDAS-CRP) (OR:1.39, p&lt;0.01) and current use of biologics (OR:1.80, p=0.05) were associated with patient-physician discordance. In multivariate logistic regression analysis, pain score (OR:1.03, p&lt;0.01), post-secondary education level (OR:0.35, p=0.04) and current biologics use (OR:2.63, p&lt;0.01) were associated with patient-physician discordance. <h3>Reference</h3> a with reference to pre-secondary <h3>Conclusions</h3> Higher pain score, lower education level and current biologics use were associated with greater patient-physician discordance. These factors should be taken into account during shared decision making. <h3>Reference</h3> [1] Desthieux C, Molto A, Granger B, Saraux A, Fautrel B, Gossec L. Patient-physician discordance in global assessment in early spondyloarthritis and its change over time: the DESIR cohort. Annals of the Rheumatic Diseases2016;75(9):1661–6. <h3>Disclosure of Interest</h3> None declared
Somatic PRAME Deletions Are Associated with Decreased Immunogenicity, Apoptosis Resistance and Poor Outcomes in Diffuse Large B-Cell Lymphoma
Authors: Katsuyoshi Takata, Daisuke Ennishi, Ali Bashashati, Saeed Saberi, Elena Viganò, Shannon Healy, Julie S Nielsen, Gianluca D' Antonio, Brad H Nelson, Sohrab P Shah, Joseph M Connors, Randy D. Gascoyne, David W. Scott, Christian Steidl
Journal: Blood (2018)
White hair in alopecia areata: Clinical forms and proposed physiopathologic mechanisms
Authors: Daniel Asz-Sigall, María Fernanda Ortega-Springall, Mariam Smith-Pliego, Erika Rodríguez-Lobato, Maria Abril Martinez-Velasco, Roberto Arenas, Colombina Vincenzi, Antonella Tosti
Journal: Journal of the American Academy of Dermatology (2019)
Trends in Oral Antibiotic Prescription in Dermatology, 2008 to 2016
Authors: John S. Barbieri, Ketaki Bhate, Kathleen P. Hartnett, Katherine E. Fleming-Dutra, David J. Margolis
Journal: JAMA Dermatology (2019)

Dermatologists prescribe more oral antibiotic courses per clinician than any other specialty, and this use puts patients at risk of antibiotic-resistant infections and antibiotic-associated adverse events.To characterize the temporal trends in the diagnoses most commonly associated with oral antibiotic prescription by dermatologists, as well as the duration of this use.Repeated cross-sectional analysis of antibiotic prescribing by dermatologists from January 1, 2008, to December 31, 2016. The setting was Optum Clinformatics Data Mart (Eden Prairie, Minnesota) deidentified commercial claims data. Participants were dermatology clinicians identified by their National Uniform Claim Committee taxonomy codes, and courses of oral antibiotics prescribed by these clinicians were identified by their National Drug Codes.Claims for oral antibiotic prescriptions were consolidated into courses of therapy and associated with the primary diagnosis from the most recent visit. Courses were stratified into those of extended duration (>28 days) and those of short duration (≤28 days).Frequency of antibiotic prescribing and associated diagnoses. Poisson regression models were used to assess for changes in the frequency of antibiotic prescribing over time.Between 2008 and 2016 among 985 866 courses of oral antibiotics prescribed by 11 986 unique dermatologists, overall antibiotic prescribing among dermatologists decreased 36.6% (1.23 courses per 100 visits) from 3.36 (95% CI, 3.34-3.38) to 2.13 (95% CI, 2.12-2.14) courses per 100 visits with a dermatologist (prevalence rate ratio for annual change, 0.931; 95% CI, 0.930-0.932), with much of this decrease occurring among extended courses for acne and rosacea. Oral antibiotic use associated with surgical visits increased 69.6% (2.73 courses per 100 visits) from 3.92 (95% CI, 3.83-4.01) to 6.65 (95% CI, 6.57-6.74) courses per 100 visits associated with a surgical visit (prevalence rate ratio, 1.061; 95% CI, 1.059-1.063).Continuing to develop alternatives to oral antibiotics for noninfectious conditions, such as acne, can improve antibiotic stewardship and decrease complications from antibiotic use. In addition, the rising use of postoperative antibiotics after surgical visits is concerning and may put patients at unnecessary risk of adverse events. Future studies are needed to identify the value of this practice and the risk of adverse events.
FRI0491 Smoking as a risk factor for giant cell arteritis: a systematic review and meta-analysis
Authors: D. Brennan, P. Ungprasert, K.J. Warrington, M.J. Koster
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Tobacco smoking is a well-established risk factor for the development of several autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. A similar association between smoking and giant cell arteritis (GCA) has been suspected but remains unclear due to limited study size and conflicting epidemiologic data. <h3>Objectives</h3> To conduct a systematic review and meta-analysis to further investigate the association between smoking and the development of GCA. <h3>Methods</h3> Two investigators (D.B. and M.K.) independently searched published studies indexed in MEDLINE and EMBASE from inception to February 2017 using the terms "giant cell arteritis," "temporal arteritis," "cranial arteritis," and "Horton disease." Recent conference abstracts available online were also reviewed. The following inclusion criteria were used: 1) original observational study comparing patients with GCA to healthy controls; 2) inclusion of smoking history; 3) provision of absolute numbers and/or statistical comparisons with 95% confidence intervals. Study eligibility was independently determined by the two investigators, with disagreements reviewed by a third investigator (P.U.) and resolved by consensus. RevMan 5.3 software was used for the data analysis. Point estimates and standard errors were extracted from individual studies and were combined by the generic inverse variance method of DerSimonian and Laird. Given the high likelihood of between-study variance, we used a random-effect model rather than a fixed-effect model. Statistical heterogeneity was assessed using the Cochran's Q test. <h3>Results</h3> The initial search yielded 3312 articles. Of these, thirteen studies (8 prospective and, 5 retrospective case-control studies) with unique cohorts were identified and included in the primary analysis (ever vs. never smoking history). Patients in the GCA cohort were more likely to have a history of smoking with an odds ratio of 1.19 (95% CI, 1.01–1.39) [figure 1A]. Considerable heterogeneity was present (I<sup>2=</sup>85%). Five of these studies included information on current smoking status. One additional study, which only reported current smoking status, was also included. The GCA cohort showed an association with current tobacco use with an odds ratio of 1.18 (95% CI, 1.01–1.38) [figure 1B]. <h3>Conclusions</h3> Our study demonstrated a statistically significant increased risk of GCA among smokers compared to non-smokers. <h3>Disclosure of Interest</h3> None declared
Abstract 12221: Low Nasal Nitric Oxide as a Biomarker for Increased Pulmonary Vascular Resistance in Congenital Heart Disease
Authors: Rukmalee Vithana, Phillip Adams, Maliha Zahid, Linda Leatherbury, Shawn West, Jacqueline Kreutzer, Cecilia Lo
Journal: Circulation (2017)

Introduction: Pulmonary arterial hypertension (PAH) reflected by increased pulmonary vascular resistance (PVR) is an important cause of mortality and morbidity in congenital heart disease (CHD). In...
THU0537 Association between big five personality traits and response to multidisciplinary program in patients with chronic low back pain: a prospective study
Authors: M.E. Ibrahim, K. Weber, S. Genevay
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Chronic back pain is a multifactorial condition, which cannot be thoroughly addressed without understanding the psychological factors that influence its onset, maintenance and the response to its management. Patient attitudes and personality traits often determine how they experience pain, how they adjust to it, and their response to the different management strategies. <h3>Objectives</h3> This study aimed to identify whether patients with specific Big Five personality traits are more likely to seek medical care, and to uncover whether there is an association between personality and the patient's response to multidisciplinary functional rehabilitation program. <h3>Methods</h3> 97 patients (57% male) aged 41.1 (10.1) with chronic low back pain, enrolling in an intensive 4 week multidisciplinary functional rehabilitation program, completed the NEO Personality Inventory-Revised (NEO PI-R) at baseline. Outcome was assessed at treatment admission and discharge, and at 6 months follow up, including Core Outcome Measure Index (COMI), Tampa Scale for Kinesiophobia (TSK), Oswestry Disability Index (ODI) and Hospital Anxiety and Depression Scale (HADS). <h3>Results</h3> Both men and women had significantly lower scores in the Openness to Experience domain and significantly higher scores in the Conscientiousness domain than the average general population. At baseline, Neuroticism was found to correlate positively with TSK and HADS. Low Openness to Experience, and low Extraversion correlated with high HADS at baseline as well. Analysis of the follow up data showed a significant reduction in the COMI, ODI, HADS and TSK at the end of the program, and at 6 months follow up. There was no correlation between the improvement in COMI, ODI or TSK scores after 6 months and any of the 5 domains of the NEO PI-R <h3>Conclusions</h3> Low Openness to Experience and high Conscientiousness seem to be key factors of chronicity in patients with low back pain. Significant decrease in pain, disability as well as depressive and anxious moods showed that these patients were effectively treated by the multidisciplinary functional rehabilitation program regardless of their personality traits. <h3>Disclosure of Interest</h3> None declared
FRI0724-HPR Disease activity affects fat mass index and functional capacity of ra patients over 12 months
Authors: R.C.E. Cavalheiro Do Espírito Santo, J. Miranda de Souza Silva, P. Lora, L. Isabel Filippin, R. Machado Xavier
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background:</h3> Rheumatoid cachexia (RC) is a condition characterized by adverse changes in body composition, specifically in muscle mass and fat mass components [1]. RA patients have life quality and expectative impacted by RC [2], but there are very few prospective data analyzing the evolution of this condition. <h3>Objectives:</h3> To assess body composition, RC, clinical features and functional capacity in RA patients followed for 12 months. <h3>Methods:</h3> 81 patients with RA, aged between 40 and 70 years, were recruited. Body composition was assessed by total body dual-energy x-ray absorptiometry (DXA) for measurement of fat mass index (FMI;Kg/m<sup>2</sup>) and fat free mass index (FFMI;Kg/m<sup>2</sup>).The patients were categorized as rheumatoid cachectic if FFMI was below the 10th percentile and FMI above the 25th percentile[1],and if FFMI was below the 25th percentile and FMI above the 50th percentile[2].Disease features assessed were disease activity score 28 (DAS28). Functional capacity was assessed by muscle strength (hand grip test;Kg) and gait speed (Time up and Go (TUG;m/s)). Frequency analysis, McNemar test and GEE analyses were used and statistical significance was considered as p&lt;0.05. <h3>Results:</h3> Of the 81 patients analyzed, most were women (88.9%;72/81), with mean age of 56.8±7.3, mean disease duration time of 11.9±9.6 years. At baseline, the prevalences of RC using both diagnostic criteria were similar to the prevalences described in literature (table 1), and they did not change during the 12 month follow-up(p&gt;0.05).FMI increased after 12 months and patients with moderate disease activity showed higher FMI when compared with other DAS28 categories(p&lt;0.05).Thus, over 12 months, DAS28 affected FMI, and had no impact on FFMI(p&gt;0.05).Muscle strength decreased significantly after 12 months, and patients with high disease activity showed less muscle strength when compared with other DAS28 categories(p&lt;0.05).Gait speed increased after 12 months(p&lt;0.05). <h3>Conclusions:</h3> In this study, RC prevalence was similar to the prevalence described in literature. DAS28 score of our patients increased over 12 months, and it affected FMI, muscle strength and gait speed of RA patients. However, no effect was observed on FFMI. Our results show that the patients that are not in remission by DAS28 have decreased muscle strength and increased fat mass, possibly due the inflammatory process and the reduced physical activity level, creating a vicious circle.This vicious circle may negatively impact on life quality of RA patients. <h3>References</h3> [1] Engvall IL, et al. Scand J Rheumatol2008. [2] Elkan AC, et al. Arthritis Res Ther. 2009. <h3>Disclosure of Interest:</h3> None declared