tbuckley/cabot-search huggingface dataset:
Military trainees can accurately measure optic nerve sheath diameter after a brief training session
Authors: Joseph Betcher, Torben K. Becker, Peter Stoyanoff, Jim Cranford, Nik Theyyunni
Journal: Military Medical Research (2018)

Identification of elevated intracranial pressure is important following traumatic brain injury. We assessed the feasibility of educating military trainees on accurately obtaining optic nerve sheath diameter measurements using a brief didactic and hands-on training session. Optic nerve sheath diameter is a noninvasive surrogate marker for elevated intracranial pressure, and may be of value in remote military operations, where rapid triage decisions must be made without access to advanced medical equipment. Military trainees with minimal ultrasound experience were given a 5-min didactic presentation on optic nerve sheath diameter ultrasound. Trainees practiced optic nerve sheath diameter measurements guided by emergency physician ultrasound experts. Trainees then measured the optic nerve sheath diameter on normal volunteers. Following this, a trained physician measured the optic nerve sheath diameter on the same volunteer as a criterion standard. An average of three measurements was taken. Twenty-three military trainees were enrolled. A mixed design ANOVA was used to compare measurements by trainees to those of physicians, with a mean difference of − 0.6 mm (P = 0.76). A Bland-Altman analysis showed that the degree of bias in optic nerve sheath diameter measures provided by trainees was very small: d = − 0.004 for the right eye and d = − 0.007 for the left eye. This study demonstrates that optic nerve sheath diameter measurement can be accurately performed by novice ultrasonographers after a brief training session. If validated, point-of-care optic nerve sheath diameter measurement could impact the triage of injured patients in remote areas.
Consumerism and Innovation in Pediatric Primary Care
Authors: Keith J. Loud, Scott A. Shipman
Journal: JAMA Pediatrics (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Abstract 14713: Evidence for Enhanced Inflammation of Coronary Adventitia and Perivascular Adipose Tissue With Altered Disease Activity in Vasospastic Angina Patients -A Multi-modality Imaging Study
Authors: Kazuma Ohyama, Yasuharu Matsumoto, Kentaro Takanami, Hideki Ota, Kensuke Nishimiya, Jun Sugisawa, Satoshi Tsuchiya, Hirokazu Amamizu, Hironori Uzuka, Akira Suda, Tomohiko Shindo, Yoku Kikuchi, Kiyotaka Hao, Jun Takahashi, Yasuhiko Sakata, Hiroaki Shimokawa
Journal: Circulation (2017)

Introduction: Recent studies implicated that perivascular components, such as perivascular adipose tissue (PVAT) and adventitial vasa vasorum (VV), play important roles as a source of various infla...
Oncogenic potential of KCNMA1 in prostate cancer.
Authors: Michael Bloch, Ronald Simon, Peter Schraml, Thomas C. Gasser, Michael J. Mihatsch, Lukas Bubendorf
Journal: Cancer Research (2004)

2266  After initial response to anti-androgen therapy, prostate cancer invariably progresses to a hormone-refractory stage with no effective therapy options being available. Tumor progression is often driven by chromosomal aberrations. We have previously found a high-level DNA amplification at 10q22 in 10-15% of late-stage prostate cancers. This amplification site contains KCNMA1, encoding for the pore forming alpha-subunit of the Ca2+ activated, large conductance K+ channel (syn. BK-channel). KCNMA1 has been shown to be a key modulator of vascular smooth muscle tone and plays a role in synaptic neurotransmitter release. Recently, it has been suggested that potassium channels may also be involved in oncogenesis. However, KCNMA1 has not been previously analyzed in prostate cancer, and DNA amplification of potassium channels has not been reported. First, we used a BAC probe containing sequences of KCNMA1 for fluorescence in situ hybridization (FISH) on a tissue microarray (TMA) representing all stages of prostate cancer progression. KCNMA1 was amplified in 13.5% of 141 hormone-refractory recurrences and metastases, but never in untreated localized prostate cancers. In addition, KCNMA1 amplification was found in the hormone-insensitive prostate cancer cell line PC-3, but not in the androgen-responsive cell line BPH-1, which originates from benign prostatic epithelial cells. Quantitative RT-PCR showed a marked over expression of BK-channel in PC-3 as compared to BPH-1. Blocking of the BK-channel by the specific BK-channel inhibitor iberiotoxin lead to a growth reduction by 15% in PC-3 but had no effect on BPH-1. To further strengthen these data we performed anti KCNMA1 siRNA revealing a 1.5-4.7-fold reduction of the average growth rate of PC-3 treated with active siRNA as compared to inactive control siRNA. This growth reduction was accompanied by changes of the cell phenotype from a spindle like shape to a spread shape. Taken together, KCNMA1 appears as a promising amplification target gene in prostate cancer, which might be involved in the progression towards late-stage hormone-refractory disease. In addition, KCNMA1 might qualify as a valuable novel therapeutic target in prostate cancer.
Within-trial cost and 1-year cost-effectiveness of the DiRECT/Counterweight-Plus weight-management programme to achieve remission of type 2 diabetes
Authors: Yiqiao Xin, Andrew Davies, Louise McCombie, Andrew Briggs, C-Martina Messow, Eleanor Grieve, Wilma S Leslie, Roy Taylor, Michael E J Lean
Journal: The Lancet Diabetes & Endocrinology (2018)
Abstract 13895: HOE642 Used During Resuscitation Induced Obviously Adverse Hemodynamic Effects Which May Be Improved by Hypothermia
Authors: Jiaxu Dong, Chaoran Nie, Meng Chen, Lina Hou, Fei Han
Journal: Circulation (2015)

Introduction: HOE642, the sodium-hydrogen exchanger inhibitor, can delay the opening of mitochondrial permeability transition pore (mPTP) and reduce mitochondrial-derived superoxide production. It was reported HOE642 improved neurological recovery after prolonged ischemia. Hypothesis: We sought to find the effects of HOE642 with or without hypothermia on resuscitation in rats. Methods: Thirty male SD rats (240-340g) were included. Cardiac arrest was induced by 8 min asphyxia. Rats were divided into 4 groups: (1) normothermia group (N group, n=9), rectal temperature (Trec) maintained at 37±0.5°C; (2) hypothermia group (H group, n=7), Trec maintained at 37±0.5°C during cardiac arrest and CPR periods, rats were cooled to 33°C in 3 min after ROSC, Trec maintained at 33±0.5°C for 1 h, rewarmed gradually to 37±0.5°C during the following 1 h; (3) HOE642 group (n=7), Trec maintained the same as the N group, HOE642 was given (1mg/kg, iv) when initiating CPR; (4) hypothermia and HOE642 group (H+HOE642 group, n=7), Trec maintained the same as the H group, HOE642 was given the same as the HOE642 group. Epinephrine (0.01mg/kg) was used when initiating CPR. Epinephrine (1μg) was used to maintain MAP ≥ 60mmHg after resuscitation. Results: There were no significant difference about the baseline characters, CA time, CPR time, and survival among groups. HOE642 did not influence the rate of ROSC. MAP in the H group (113.4±36.7mmHg) was significantly higher than the HOE642 group (67.4±18.5mmHg) and the H+HOE642 group (69.0±17.6mmHg) when ROSC (Fig. 1). MAP in the H group (77.4±21.1mmHg) was significantly higher than the HOE642 group (55.1±18.4mmHg) after 60 min of ROSC. Epinephrine used after ROSC in the HOE642 group (9.4±5.3μg) was significantly more than the N group (0.9±1.1μg), the H group (1.6±1.8μg), and the H+HOE642 group (2.3±1.6μg). Conclusions: HOE642 used during resuscitation induced hypotension. Hypothermia may prevent the adverse hemodynamic effects caused by HOE642.
Low aspirin use and high prevalence of pre-eclampsia risk factors among pregnant women in a multinational SLE inception cohort
Authors: Arielle Mendel, Sasha B Bernatsky, John G Hanly, Murray B Urowitz, Ann Elaine Clarke, Juanita Romero-Diaz, Caroline Gordon, Sang-Cheol Bae, Daniel J Wallace, Joan T Merrill, Jill P Buyon, David A Isenberg, Anisur Rahman, Ellen M Ginzler, Michelle Petri, Mary Anne Dooley, Paul R Fortin, Dafna D Gladman, Kristján Steinsson, Rosalind Ramsey-Goldman, Munther A Khamashta, Cynthia Aranow, Meggan Mackay, Graciela S Alarcón, Susan Manzi, Ola Nived, Andreas Jönsen, Asad A Zoma, Ronald F van Vollenhoven, Manuel Ramos-Casals, Guillermo Ruiz-Irastorza, Sam Lim, Ken C Kalunian, Murat Inanc, Diane L Kamen, Christine A Peschken, Søren Jacobsen, Anca Askanase, Jorge Sanchez-Guerrero, Ian N Bruce, Nathalie Costedoat-Chalumeau, Évelyne Vinet
Journal: Annals of the Rheumatic Diseases (2018)

Table 1 Characteristics of SLE pregnancies overall and according to aspirin use Characteristic All pregnant visits (n=475)* Pregnant visits with aspirin (n=121) Pregnant visits without aspirin (n=354) Patient characteristic Age, mean (SD) 31.0 (4.9) 30.5 (4.6) 31.2 (5.0) Ethnicity, n (%) Asian 66 (14) 7/66 (11) 59/66 (89) Native North American 3 (1) 2/3 (67) 1/3 (33) Black 88 (19) 9/88 (10) 79/88 (90) Caucasian 209 (44) 71/209 (34) 138/209 (66) Hispanic 62 (13) 20/62 (32) 42/62 (68) Indian subcontinent 25 (5) 8/25 (32) 17/25 (68) Other 22 (5) 4/22 (18) 18/22 (82) Country, n (%)
AB0115 Scleroderma-like changes in a diabetic patient: a clinical case
Authors: M Cruz, A Alves de Matos, JC Branco
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> Diabetes mellitus is a metabolic systemic disease that can be associated, particularly when glucose metabolism control is poor, with skin changes and sometimes finger contractures of the hands that clinically resemble scleroderma. Distinction between the two different conditions is important, because they have distinct therapeutic approach and prognostic. A 55 year-old white woman came to our Unit because of skin changes and articular contractures. She had diabetes mellitus since a gestation eleven years ago and was being followed in the Endocrinology department for this reason. Her disease had been resistant to antidiabetic oral treatment and was complicated with a severe polyneuropathy in glove and stoking pattern. Control of glucose metabolism was poor and she was being teached to start insulin therapy. She had been also diagnosticated of an autoimmune tiroiditis and recent arterial hypertension. We observed a thin woman wiyh yight shiny skin over her fingers and unreduceable contractures of some of them in both hands. The skin of her distal legs was billaterally swelled and sclerotic too. She refered a Raynaud fenomenon, which we weren´t able to provoque with cold water. There were no other musculoskeletal findings or symptoms suggesting CREST or systemic disease beyond diabetes. Her ANA and anti-DNA were negative, as was anticentrome antibody and Scl70. The hand x-rays showed neither calcifications nor erosions. A capilaroscopy was performed, showing some megacapilaries and structural disorganisation. No avascular areas were found. We concluded, in face of the analytic results, that this was a scleroderma-like manifestation of diabetic cheiroarthropathy and not systemic or limited scleroderma. The changes seen in the capilaroscopy could be due to the cheiroarthropathy itself. <h3>Objectives</h3> <h3>Methods</h3> <h3>Results</h3> <h3>Conclusion</h3>
International, Prospective Study Comparing Nilotinib Versus Imatinib with Early Switch to Nilotinib to Obtain Sustained Treatment-Free Remission in Patients with Chronic Myeloid Leukemia. a GIMEMA and HOVON Study
Authors: Fabrizio Pane, Luigia Luciano, Novella Pugliese, Juan Luis Steegman, Peter E. Westerweel, Elisabetta Abruzzese, Massimo Breccia, Monica Bocchia, Simona Soverini, Fausto Castagnetti, Maria Monteverde, Gianantonio Rosti, Giuseppe Saglio, Jeroen J. Janssen
Journal: Blood (2018)
Enhanced Pulmonary Artery Radiodensity in Pulmonary Arterial Hypertension: A Sign of Early Calcification?
Authors: Virginie F. Tanguay, Camille Babin, Gabrielle Giardetti, Catherine Sohier-Poirier, Vincent Ménard-Cholette, Benoît Ranchoux, Grégoire Ruffenach, David Montani, Sébastien Bonnet, Steeve Provencher
Journal: American Journal of Respiratory and Critical Care Medicine (2018)
Relationship between pollen concentrations and short-acting β<sub>2</sub>-agonist bronchodilator sales in central France: a daily time-series analysis over a 5-year period
Authors: Denis M. Caillaud, Sylvie Martin, Claire Ségala, Bertrand Evrard, Nihade Adrouche
Journal: European Respiratory Journal (2019)

<b><i>Betula</i>, <i>Quercus</i>, <i>Fraxinus, Carpinus</i> and <i>Platanus</i> tree pollens contribute to asthma morbidity and consequent sales of SABA medications in the general population in central France, and <i>Poaceae, Corylus</i> and <i>Ambrosia</i> in some age classes</b>http://bit.ly/2LWQQVs
Abstract 15618: Anatomy Does Matter: The Relationship Between Catheter-Tissue Contact Force and Anatomical Variations of Left Atrium
Authors: Akinori Sairaku, Yukiko Nakano, Kazuyoshi Suenari, Yasuki Kihara
Journal: Circulation (2015)

Background: Adequate catheter-to-myocardial contact force (CF) and catheter stability are important to create transmural lesions during catheter ablation of atrial fibrillation (AF). It is known that there are anatomical variations in left atrium (LA) and it is related to the outcome after the ablation. We tested any relationship between the CF and LA anatomical variations. Methods: Consecutive patients undergoing radiofrequency-based extensive encircling pulmonary vein (PV) isolation for the treatment of paroxysmal AF were dichotomized according to the LA anatomical variations; patients who had a PV-bifurcation region of LA ridge that was steep enough to enable a stable catheter-tip contact or a left common PV (group 1, the red arrows in Figure 1), or those who had neither (group 2, the blue arrows in Figure 1). The blinded operators carried out the procedure with the use of CARTO system, and the following VisiTag™ module setting was applied; a minimum time spent in an area of 5 seconds, a maximum distance the catheter has moved of 4mm, a force over time of 25%, and a minimum force of 10g. Low-CF tags was defined as ablation tags on CARTO map located at anterior aspect of left PVs that did not fulfill the pre-determined VisiTag™ criteria. The endpoints were the number of low-CF tags and freedom from AF 1 year after the ablation. Results: Patients in group 1 (n=31) had a smaller number of low-CF tags than those in group 2 (n=55, 2.8±2.1 vs. 5.9±3.8; p=0.013). Freedom from AF was more common in group 1 compared to group 2 (80.6% vs. 60%; p=0.04), and was independently associated with the number of low-CF of &lt;3 (hazard ratio 2.4, confidence interval 1.12-6.87; p=0.026). Conclusions: Contact of the catheter-tip with the tissue may predict outcome after AF ablation, and it may depend on LA anatomical variations.
Associations of early life and adulthood adiposity with risk of epithelial ovarian cancer
Authors: T. Huang, S.S. Tworoger, W.C. Willett, M.J. Stampfer, B.A. Rosner
Journal: Annals of Oncology (2018)

Few studies have evaluated the association between early life adiposity and ovarian cancer risk. Adiposity during different periods of life may be differentially associated with the risk.
Detection and Surveillance of Bladder Cancer Using Urine Tumor DNA
Authors: Jonathan C. Dudley, Joseph Schroers-Martin, Daniel V. Lazzareschi, William Y. Shi, Simon B. Chen, Mohammad S. Esfahani, Dharati Trivedi, Jacob J. Chabon, Aadel A. Chaudhuri, Henning Stehr, Chih Long Liu, Harumi Lim, Helio A. Costa, Barzin Y. Nabet, Mandy L.Y. Sin, Joseph C. Liao, Ash A. Alizadeh, Maximilian Diehn
Journal: Cancer Discovery (2018)

Abstract Current regimens for the detection and surveillance of bladder cancer are invasive and have suboptimal sensitivity. Here, we present a novel high-throughput sequencing (HTS) method for detection of urine tumor DNA (utDNA) called utDNA CAPP-Seq (uCAPP-Seq) and apply it to 67 healthy adults and 118 patients with early-stage bladder cancer who had urine collected either prior to treatment or during surveillance. Using this targeted sequencing approach, we detected a median of 6 mutations per patient with bladder cancer and observed surprisingly frequent mutations of the PLEKHS1 promoter (46%), suggesting these mutations represent a useful biomarker for detection of bladder cancer. We detected utDNA pretreatment in 93% of cases using a tumor mutation–informed approach and in 84% when blinded to tumor mutation status, with 96% to 100% specificity. In the surveillance setting, we detected utDNA in 91% of patients who ultimately recurred, with utDNA detection preceding clinical progression in 92% of cases. uCAPP-Seq outperformed a commonly used ancillary test (UroVysion, P = 0.02) and cytology and cystoscopy combined (P ≤ 0.006), detecting 100% of bladder cancer cases detected by cytology and 82% that cytology missed. Our results indicate that uCAPP-Seq is a promising approach for early detection and surveillance of bladder cancer. Significance: This study shows that utDNA can be detected using HTS with high sensitivity and specificity in patients with early-stage bladder cancer and during post-treatment surveillance, significantly outperforming standard diagnostic modalities and facilitating noninvasive detection, genotyping, and monitoring. This article is highlighted in the In This Issue feature, p. 453
Abstract 19955: A New Method Using Cardiac Computed Tomography to Analyze Left Atrial Appendage and Thereby Predict Stroke Risk in Patients With Atrial Fibrillation
Authors: Takafumi Inoue, Yoshihiro Suematsu
Journal: Circulation (2017)

Introduction: The objective of this study was to investigate a new diagnostic approach for predicting stroke risk in patients with atrial fibrillation (AF). Hypothesis: A poor enhancement of LAA in...
MCRN¯003/MYX·1: A Single Arm Phase II Study of High-Dose Weekly Carfilzomib Plus Cyclophosphamide and Dexamethasone in the Treatment of Relapsed Multiple Myeloma after 1-3 Prior Therapies
Authors: Christopher P. Venner, Richard Leblanc, Irwindeep Sandhu, Darrell J. White, Andrew R Belch, Donna E Reece, Christine I Chen, Sean Dolan, Andrea Kew, Marc Lalancette, Martha L Louzada, Arleigh McCurdy, Gail T. McDonald, Tony Reiman, Laura Rodriguez, Lois E. Shepherd, Engin Gul, Bingshu E. Chen, Annette E Hay
Journal: Blood (2018)
Abstract 17159: Methionine Sulfoxide Reductase a Inducer Acacetin Confers Remarkable Anti-oxidation Effects Through Nrf2 Pathway in Human Endothelial Cells
Authors: Yao Wu, Yun-Da Li, Wei-Yin Wu, Gang Li, Gui-Rong Li, Yan Wang
Journal: Circulation (2017)

Introduction: Methionine sulfoxide reductase A (MsrA) is an important intracellular oxidoreductase and has significant cellular protection against oxidative damage. Our previous study has demonstra...
Abstract 19048: Association Between Particulate Matter and Hospitalization for Heart Failure: Personalized Risk Assessment With Macro-Environmental Factors
Authors: Shao-Yuan Chuang, Shih-Hsien Sung, Chai-Huang Lai
Journal: Circulation (2017)

Introduction: Atmospheric particulate matter (PM) has been associated with increased risks for heart failure (HF). However, the individual susceptibility to PM might vary, given the discrepancies i...
Retrospective analysis of the clinicopathologic profile of ALK-positive patients in the south of Spain.
Authors: Miriam Gonzalez de la Peña, Michele Biscuola, Amparo Sanchez Gastaldo, Miriam Alonso, Lourdes Gomez Izquierdo, Jesus Corral
Journal: Journal of Clinical Oncology (2013)

e19105 Background: The anaplastic lymphoma kinase (ALK) fusion gene is a key oncogenic driver in a subset of patients with advanced non small cell lung cancer (NSCLC). ALK rearragement is detected in 2-7% of NSCLC patients. Fluorescence in situ hybridization (FISH) is the recommended method of detection. The clinical features of lung cancer that harbors ALK include light- or never-smokers, younger age, adenocarcinomas with acinar pattern or signet ring adenocarcinoma, and a lack of EGFR or KRASmutations. Crizotinib has shown an important benefit in terms of overall response rate (ORR) and progression free survival (PFS) in the 2nd/3rd line setting. Treatment related adverse events include gastrointestinal and visual disorders. Methods: Retrospective analysis of the clinico-pathological profile of ALK NSCLC patients between May 2011 and December 2012 in our region. Results: 10 cases (6,7%) were identified from 150 screened patients with adenocarcinoma histology and EGFR wild-type status. 7 (70%) patients were women. Median age at diagnosis was 62 years old (36-77). 9 (90%) patients were light-or-never smokers. All tumors were adenocarcinomas with EGFR wild-type status: Acinar growth pattern was detected in 4 cases (40%); 4 (40%) patients showed mucous cells and previous described signet-ring cells were detected in the last 2 (20%) cases. Only 5 (50%) patients received crizotinib therapy: 2 patients were treated during 1 st line with partial response, 1 patient on 2 nd line with stable disease and 2 patients received treatment in 3 rd line with partial response. Only one patient required a dose reduction due to a grade 3 nausea and mucositis. Conclusions: Most of the patients with ALK rearragements in our serie have clinical and pathological characteristics to previously described. More women and older population were showed. In stead of the small sample size, pathological pattern based on acinar growth and mucous or signet-ring cells in adenocarcinomas with no EGFR mutation should guide the ALK screening. ORR and toxicity profile confirmed Crizotinib benefit as soon as ALK status was detected.