SAT0517 Gender differences influences clinical presentation and vascular pattern in patients with takayasu arteritis: an italian monocentric study
Authors: A. Tomelleri, C. Campochiaro, S. Sartorelli, A. Cariddi, G. Cavalli, E. Baldissera, L. Dagna
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Takayasu arteritis(TA) is a large-vessel vasculitis affecting aorta and its major branches<sup>1</sup>. Vascular inflammation may cause luminal narrowing, occlusion or aneurysms<sup>2</sup>. TA affects more frequently young women, but occurrence in patients&gt;40 years is not rare. Female:male ratio is 9:1<sup>3</sup> <h3>Objectives</h3> To compare age at disease onset, age at diagnosis and diagnostic delay between male and female Italian TA patients from our cohort. To compare symptoms presentation and vascular involvement <h3>Methods</h3> Data from 10 male and 104 female TA patients (fulfilling ACR criteria) from our tertiary centre were retrospectively collected. Age at diagnosis, age at first symptom onset, diagnostic delay, signs and symptoms subsequently attributed to TA, and arteries involved before the diagnosis were compared. Non-parametric statistic tests were used <h3>Results</h3> In male patients mean age at diagnosis was 33.5±14.64 years and mean age at onset was 25.8±13.01 years. In female patients mean age at diagnosis was 36.26±12.6 years and mean age at onset was 31±13.1 years. The differences not being statistically significant. The highest percentage of male patients disease onset was &lt;18 years (40%), in female patients it was between 18–40 years (61.5%). Mean diagnostic delay was 92.9±80.78 months in male and 63.03±85.63 in female patients(p=0.050). Features at disease onset are summarised in table 1. Frequency of limbs claudication was not significantly different in the two groups (50% vs 56.7%), 10% of male patients had upper limbs claudication, compared to 43.3% of female patients, p=0.047. Arterial hypertension was more frequent in male patients (70% vs 35.6%, p=0.044). Acute coronary syndrome was more frequent in male patients (30% vs 5.8%, p=0.031). Frequency of cardiovascular risk was not significantly different in the two groups (40% vs 32.7%). Coronary angiography was more frequently performed in male patients (30% vs 2.9%, p=0.009). At disease onset, compared to female patients, male patients coronary (30% vs 6.7%,p=0.042), iliac (50% vs 15.4%,p=0.018) and femoral arteries (40% vs 6.6%,p=0.008) were more frequently involved. In female patients subclavian arteries were more frequently involved (72% vs 40%, p=0.066). <h3>Conclusions</h3> Male patients with TA have more frequent involvement of the coronary arteries and of the iliac and femoral arteries. As a consequence, they suffer more frequently acute coronary syndrome and lower limbs claudication. Besides, they have more frequently arterial hypertension <h3>References</h3> [1] Numano F, et al. Takayasu arteritis. Lancet2000. [2] Clomarmond C, et al. Long-Term Outcomes and Prognostic Factors of Complications in Takayasu Arteritis. Circulation2017. [3] Fatos O, et al. Epidemiology of Takayasu arteritis. Presse Med2017. <h3>Disclosure of Interest</h3> A. Tomelleri: None declared, C. Campochiaro: None declared, S. Sartorelli: None declared, A. Cariddi: None declared, G. Cavalli: None declared, E. Baldissera: None declared, L. Dagna Grant/research support from:&gt;&gt;The Unit has received unrestricted educational grants from Abbvie, BMS, Celgene, Mundipharma, Novartis, MSD, Pfizer, Roche, and SOBI.