tbuckley/cabot-search huggingface dataset:
SAT0594 LONG-TERM MORBIDITY FOLLOWING IGA VASCULITIS IN CHILDHOOD
Authors: J. “. Nossent, W. Raymond, M. Ognjenivic, H. Keen, D. Preen, C. Inderjeeth
Journal: Annals of the Rheumatic Diseases (2020)

Background: IgA vasculitis (IgAV) in children is considered a mostly self-limiting disease. However, patients may require aggressive initial treatment, are prone to disease relapses and conceivably have a sustained abnormality in mucosal and /or circulating IgA responsiveness, that can predispose to the development of other conditions. Objectives: To determine whether childhood IgAV predisposes to comorbidity later in life. Methods: Observational cohort study examining rates of hospitalization, ED visits, procedures and accrual of comorbidity (by Charlson comorbidity index; CCI) comparing 494 IgAV patients &lt;20 years at diagnosis with 1385 non-exposed matched controls over a 20-year period. Maximum likelihood estimates were used to obtain Odds (OR) and Rate ratios per 1000 person-years (RR). Results: Hospitalization was increased proportionally (73.5 vs 51.5%) and by rate (21.7 vs 18.9; rate ratio 1.15) (both p&lt;0.01) for IgAV patients, who underwent more diagnostic and medical procedures whereas controls had higher rates of surgical interventions. IgAV patients had an higher overall ED attendance (25 vs 16%) and visit rate (10.8 vs 8.43, RR 1.29) (each p&lt;0.01)) and accrued more often peptic ulcer and renal disease and developed severe comorbidity (CCI ≥3) at a higher rate (OR 2.9, 95% CI 0.79-11.6) than controls. Conclusion: A diagnosis of IgAV in childhood associates with increased risk and rate of subsequent hospital admission, ED attendance and severe comorbidity. The occurrence of childhood IgAV thus signifies the presence of a sustained predisposition to illness. Acknowledgments: Supported by an unrestricted grant from the Arthritis Foundation of Western Australia Disclosure of Interests: Johannes (“Hans”) Nossent Speakers bureau: Janssen, warren raymond: None declared, milica ognjenivic: None declared, Helen Keen Speakers bureau: Pfizer Austrlaia, Abbvie Australia, David Preen: None declared, Charles Inderjeeth Grant/research support from: UCB Australia, Speakers bureau: Eli Lilly
Peering Into Cancer
Authors: L. Ritsma, E.J.A. Steller, E. Beerling, C.J.M. Loomans, A. Zomer, C. Gerlach, N. Vrisekoop, D. Seinstra, L. van Gurp, R. Schafer, D.A. Raats, A. de Graaff, T.N. Schumacher, E.J.P. de Koning, I.H.B. Rinkes, O. Kranenburg, J. van Rheenen
Journal: Science Translational Medicine (2012)
Early Parenting Intervention Effects on Brain Responses to Maternal Cues Among High-Risk Children
Authors: Emilio A. Valadez, Nim Tottenham, Alexandra R. Tabachnick, Mary Dozier
Journal: American Journal of Psychiatry (2020)

Objective: Early adversity is correlated with increased risk for negative outcomes, including psychopathology and atypical neurodevelopment. The authors aimed to test the causal impact of an early parenting intervention (Attachment and Biobehavioral Catch-Up; ABC) on children’s neural processing of parent cues and on psychosocial functioning in a longitudinal randomized clinical trial. Methods: Participants (N=68, mean age, 10.0 years [SD=0.8 years]) were 46 high-risk children whose parents were randomly assigned to receive either the ABC intervention (N=22) or a control intervention (N=24) while the children were infants, in addition to a comparison sample of low-risk children (N=22). During functional MRI scanning, children viewed pictures of their own mothers and of a stranger. Results: Children in the ABC condition showed greater maternal cue-related activation than children in the control condition in clusters of brain regions, including the precuneus, the cingulate gyrus, and the hippocampus, regions commonly associated with social cognition. Additionally, greater activity in these regions was associated with fewer total behavior problems. There was an indirect effect of early intervention on middle childhood psychosocial functioning mediated through increased activity in brain regions in response to maternal cues. Conclusions: These results suggest that early parenting intervention (in this case the ABC intervention) can enhance brain regions supporting children’s social cognitive development. In addition, the findings highlight these brain effects as a possible neural pathway through which ABC may prevent future behavior problems among high-risk children, yielding psychosocial benefits that endure through at least middle childhood without the need to intervene with the child directly.
Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Kinase Transcriptional and Biochemical Function
Authors: Conor N. Gruber, Jorg J.A. Calis, Sofija Buta, Gilad Evrony, Jerome C. Martin, Skyler A. Uhl, Rachel Caron, Lauren Jarchin, David Dunkin, Robert Phelps, Bryn D. Webb, Jeffrey M. Saland, Miriam Merad, Jordan S. Orange, Emily M. Mace, Brad R. Rosenberg, Bruce D. Gelb, Dusan Bogunovic
Journal: Immunity (2020)
<i>Notes from the Field:</i> Amphetamine Use Among Workers with Severe Hyperthermia — Eight States, 2010–2019
Authors: Andrew S. Karasick, Richard J. Thomas, Dawn L. Cannon, Kathleen M. Fagan, Patricia A. Bray, Michael J. Hodgson, Aaron W. Tustin
Journal: MMWR Morbidity and Mortality Weekly Report (2020)
The Effect of a Novel Low-Volume Aerobic Exercise Intervention on Liver Fat in Type 2 Diabetes: A Randomized Controlled Trial
Authors: Angelo Sabag, Kimberley L. Way, Rachelle N. Sultana, Shelley E. Keating, James A. Gerofi, Vivienne H. Chuter, Nuala M. Byrne, Michael K. Baker, Jacob George, Ian D. Caterson, Stephen M. Twigg, Nathan A. Johnson
Journal: Diabetes Care (2020)

The aim of this study was to examine the effect of a novel low-volume high-intensity interval training (HIIT), moderate-intensity continuous training (MICT), or placebo (PLA) intervention on liver fat, glycemia, and cardiorespiratory fitness using a randomized placebo-controlled design.Thirty-five inactive adults (age 54.6 ± 1.4 years, 54% male; BMI 35.9 ± 0.9 kg/m2) with obesity and type 2 diabetes were randomized to 12 weeks of supervised MICT (n = 12) at 60% VO2peak for 45 min, 3 days/week; HIIT (n = 12) at 90% VO2peak for 4 min, 3 days/week; or PLA (n = 11). Liver fat percentage was quantified through proton MRS.Liver fat reduced in MICT (-0.9 ± 0.7%) and HIIT (-1.7 ± 1.1%) but increased in PLA (1.2 ± 0.5%) (P = 0.046). HbA1c improved in MICT (-0.3 ± 0.3%) and HIIT (-0.3 ± 0.3%) but not in PLA (0.5 ± 0.2%) (P = 0.014). Cardiorespiratory fitness improved in MICT (2.3 ± 1.2 mL/kg/min) and HIIT (1.1 ± 0.5 mL/kg/min) but not in PLA (-1.5 ± 0.9 mL/kg/min) (P = 0.006).MICT or a low-volume HIIT approach involving 12 min of weekly high-intensity aerobic exercise may improve liver fat, glycemia, and cardiorespiratory fitness in people with type 2 diabetes in the absence of weight loss. Further studies are required to elucidate the relationship between exercise-induced reductions in liver fat and improvements in glycemia.
AB0993 A CASE SERIES OF KAWASAKI DISEASE FROM KENYA
Authors: C. Njeru, A. Migowa
Journal: Annals of the Rheumatic Diseases (2020)

Background: Kawasaki disease (KD) has been described across the globe, including the African continent, but none yet from Kenya. Objectives: To describe the clinical features and management strategies of pediatric patients diagnosed with Kawasaki Disease at a tertiary referral hospital in Kenya. Methods: A retrospective chart review was undertaken for the period January 2013 to December 2017 for all pediatric patients admitted at Aga Khan University Hospital Nairobi, Kenya. All medical records with a discharge diagnosis of Kawasaki disease were reviewed, de-identified and data extracted using a data collection tool. Results: Among the 15 cases identified, 8 (53%) had complete KD. The mean age was 1 year 10 months with a slight increase in males (53.3%). The mean duration of symptoms at diagnosis was 7.2 days (range 1-11 days). Fourteen patients (93.3%) received both intravenous immunoglobulin and aspirin but dosing varied from high dose aspirin (80-90 mg/kg/day) to low dose aspirin (3 mg/kg/day). Baseline cardiac evaluations were done among these 14 (93.3%) and one patient was found to have bilateral dilated coronaries. Only 5 patients (33.3%) had repeat echo examinations within 6 weeks after diagnosis all of which were normal. Conclusion: The challenges faced in the management of KD in Kenya include awareness of the disease, access and expertise to pediatric echocardiography, follow-up, access and cost of IVIG. Increasing awareness and improving health care resources is important in improving outcomes of KD in Kenya. Keywords: Kawasaki Disease, Pediatric Rheumatology, Kenya, Global Health, Vasculitis References: [1]McCrindle BW, Rowley AH, Newburger JW, Burns JC, Bolger AF, Gewitz M, Baker AL, Jackson MA, Takahashi M, Shah PB, Kobayashi T, Wu MH, Saji TT, Pahl E. Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association. Circulation. 2017;135(17):e927-e999. [2]Kawasaki T. Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children. Arerugi (Japanese) 1967;16:178–222. [3]Singh S, Sharma A, Jiao F. Kawasaki Disease: Issues in Diagnosis and Treatment – A Developing Country Perspective. Indian J Pediatr 2016:83(2):140–145. [4]Scuccimarri R. Kawasaki Disease. Pediatr Clin N Am 2012; 59:425–445. Disclosure of Interests: None declared
Are Observational, Real-World Studies Suitable to Make Cancer Treatment Recommendations?
Authors: Rahul Banerjee, Vinay Prasad
Journal: JAMA Network Open (2020)

Abhishek Kumar, MD, MAS; Zachary D. Guss, MD; Patrick T. Courtney, BA; Vinit Nalawade, MS; Paige Sheridan, MPH; Reith R. Sarkar, MD, MAS; Matthew P. Banegas, PhD, MPH; Brent S. Rose, MD; Ronghui Xu, PhD, MA; James D. Murphy, MD, MS
Contemporary Techniques of Prostate Dissection for Robot-assisted Prostatectomy
Authors: Alberto Martini, Ugo Giovanni Falagario, Arnauld Villers, Paolo Dell’Oglio, Elio Mazzone, Riccardo Autorino, Marcio Covas Moschovas, Maurizio Buscarini, Carlo Andrea Bravi, Alberto Briganti, Guilherme Sawczyn, Jihad Kaouk, Mani Menon, Silvia Secco, Aldo Massimo Bocciardi, Gongxian Wang, Xiaochen Zhou, Francesco Porpiglia, Alexandre Mottrie, Vipul Patel, Ashutosh K. Tewari, Francesco Montorsi, Richard Gaston, N. Peter Wiklund, Ashok K. Hemal
Journal: European Urology (2020)
AB0298 LONG-TERM SUPPRESSION OF RAPID RADIOGRAPHIC PROGRESSION AFTER DISCONTINUATION/REDUCTION OF SHORT-TERM BIOLOGIC THERAPY IN PATIENTS WITH EARLY DESTRUCTIVE RHEUMATOID ARTHRITIS ACCOMPANIED WITH EXTENSIVE BONE MARROW EDEMA.
Authors: K. Katayama, T. Okubo, T. Sato, R. Fukai, M. Yuichi, K. Yujiro, H. Ito
Journal: Annals of the Rheumatic Diseases (2020)

Background: We reported that short-term (3 or 6 months) treatment with biologics (BIO) group compared with conventional synthetic non-biological disease-modifying anti rheumatic drug (csDMARDs) enhanced group is more effective in the reducing bone marrow edema (BE) and improving structural remission in early destructive RA accompanied with extensive hand BM despite csDMARDs therapy (1). Objectives: Purpose of this extended study is to investigate whether suppression of RRP will maintain after the discontinuation/reduction of short term biological treatment during over 1 year. Clinical registration number; (UMIN-CTR 000013614)(Figure 1) Methods: RA disease activity was evaluated by DAS28-ESR after BIO withdrawal/reduction at 12 months. Bone destruction was determined by modified total Sharp scoring (mTSS) using by conventional radiography expressed as yearly progression of mTSS (ΔmTSS/y) at 12 months. Statistical analysis were performed by t-test or Wilcoxon rank sum test using SAS .13.2 software Results: Fourteen out of 23 patients in BIO group achieved improvement of BM (&gt;70% improvement of baseline BE). Three patient continued BIO. Among 11 patient started to discontinuation/reduction of BIO, 7 patients were successful for discontinuation of BIO. Four patients flared (Table 1). Mean DAS28-ESR, mean ΔmTSS/y at 0, 12 months after discontinuation in 7 patients were 1.77, 2.02 and -0.66,-0.44, respectively (no significant difference between values in 0 and12 month). In contrast, those in 4 flared patients were 1.91, 4.08 and 0, 1.83, respectively (significant difference). Finally, to resolve baseline prognostic factors for improvement of BE for biological treatment, we compared baseline data between 14 BE improved and 9 BE unimproved RA patients. Low DAS28-ESR at 3 or 6 month (P&lt;0.001) are indicated for significant prognostic factor for improvement of BE, although Low DAS28-ESR at baseline (P=0.07) may associate improvement of BE. Table 1. Summary of 1 year clinical data in 11 patients treated in BIO discontinuation/reduction after improvement of BE by short-term treatment of BIO Conclusion: Results of this study indicated suppression of RRP will maintain during over 1 year after the discontinuation of short term biological treatment in some patients. We recommend that a short-term treatment with biologics for early RA patients, who are resistant to non-bio DMARDs therapy and at high risk to transit to RRP, will be an effective and economical treatment strategy. References: [1]K. Katayama, T. Okubo, S. Sato et al. Prevention of extensive bone marrow edema and consequent rapid radiographic progression by short term usage of biologics in DMARDs resistant patients with early destructive rheumatoid arthritis. EULAR meeting. FRI 0124(2018). Disclosure of Interests: None declared
Analysis of Ugandan cervical carcinomas identifies human papillomavirus clade–specific epigenome and transcriptome landscapes
Authors: Alessia Gagliardi, Vanessa L. Porter, Zusheng Zong, Reanne Bowlby, Emma Titmuss, Constance Namirembe, Nicholas B. Griner, Hilary Petrello, Jay Bowen, Simon K. Chan, Luka Culibrk, Teresa M. Darragh, Mark H. Stoler, Thomas C. Wright, Patee Gesuwan, Maureen A. Dyer, Yussanne Ma, Karen L. Mungall, Steven J. M. Jones, Carolyn Nakisige, Karen Novik, Jackson Orem, Martin Origa, Julie M. Gastier-Foster, Robert Yarchoan, Corey Casper, Gordon B. Mills, Janet S. Rader, Akinyemi I. Ojesina, Daniela S. Gerhard, Andrew J. Mungall, Marco A. Marra
Journal: Nature Genetics (2020)
Anti–Neutrophil Extracellular Trap Antibodies and Impaired Neutrophil Extracellular Trap Degradation in Antiphospholipid Syndrome
Authors: Yu Zuo, Srilakshmi Yalavarthi, Kelsey Gockman, Jacqueline A. Madison, Johann E. Gudjonsson, J. Michelle Kahlenberg, W. Joseph McCune, Paula L. Bockenstedt, David R. Karp, Jason S. Knight
Journal: Arthritis & Rheumatology (2020)

Objective The release of neutrophil extracellular traps (NETs) by hyperactive neutrophils has recently been recognized to play an important role in antiphospholipid syndrome (APS). This study was undertaken to evaluate autoantibodies targeting NETs in patients with primary APS, and to determine their potential functions and clinical associations. Methods We measured global anti‐NET activity in 76 patients with primary APS, 23 patients with systemic lupus erythematosus without antiphospholipid antibodies (aPL), 11 patients with a history of unprovoked venous thrombosis without aPL, and 44 healthy controls. The ability of APS sera to degrade NETs was also assessed. Results We found markedly elevated levels of anti‐NET IgG and IgM in patients with primary APS compared with healthy controls (for IgG, mean ± SD optical density 0.55 ± 0.34 versus 0.33 ± 0.17; for IgM, mean ± SD optical density 0.76 ± 0.51 versus 0.26 ± 0.23). This anti‐NET activity did not correlate with levels of traditional aPL and was relatively stable over time. Mechanistically, anti‐NET antibodies (especially of the IgG isotype) impaired the ability of patient sera to degrade NETs (r = 0.4, P = 0.003). Levels of anti‐NET IgM inversely correlated with complement C4 (r = 0.4, P = 0.019). Clinically, anti‐NET antibodies associated with certain APS clinical manifestations, and in particular recurrent venous thrombosis (odds ratio 4.3; P = 0.002). Interestingly, anti‐NET antibody levels also appeared to be associated with unprovoked venous thrombosis in the general population (for IgM, mean ± SD optical density 0.67 ± 0.34 versus 0.26 ± 0.23). Conclusion Our data indicate high levels of anti‐NET antibodies in patients with primary APS, which may impair NET clearance and activate the complement cascade. These findings may ultimately enable more effective risk stratification.
Retraction notice for: “Characteristics and risk factors for COVID-19 diagnosis and adverse outcomes in Mexico: an analysis of 89,756 laboratory-confirmed COVID-19 cases.” Theodoros V. Giannouchos, Roberto A. Sussman, José M. Mier, Konstantinos Poulas and Konstantinos Farsalinos.<i>Eur Respir J</i>2020; in press.
Journal: European Respiratory Journal (2020)

<h3>Objectives</h3> Interpersonal violence is an increasingly recognised risk of sport participation and causally linked to negative physical and mental health outcomes. Para athletes from low- and middle-income countries may be at highest risk of physical, psychological, sexual and neglect-related violence due to various factors; however, their perceptions of these abusive behaviours are unknown. This study examined the perceptions and experiences of abuse in para athletes from three lower resourced countries: Ghana, India and Brazil. <h3>Methods</h3> Qualitative data from semistructured focus group interviews conducted with 26 individuals were collected to explore characteristics of abuse observed, navigated and experienced by para athletes. The framework method for multidisciplinary qualitative research guided data analysis. <h3>Results</h3> Athletes identified a wide range of abusive behaviours they experienced within and outside of sport, including psychological, emotional, physical, sexual and neglect-related violence, which operated on both interpersonal and systemic levels. Most athletes described three less easily recognised forms of abuse in greater detail and more frequently than others: financial abuse, neglect and disability stigma. <h3>Conclusion</h3> It is important to hear directly from athletes with diverse experiences and backgrounds and to integrate their insights and priorities into sport safeguarding policies, programmes and interventions. Understanding the requirements and challenges of para athletes and para sport is needed to achieve safe, equitable and inclusive sport. As new insights from diverse sport settings are added to the evidence base, globally balanced, athlete-generated and locally relevant preventative strategies can better protect all athletes.
Abstract 14439: Cardiac 123-Iodine Meta-Iodobenzylguanidine Imaging to Predict Response to Cardiac Resynchronization Therapy
Authors: See Hooi Ewe, Mark J Boogers, Maureen M Henneman, Petra Dibbets-Schneider, Rutger J van Bommel, Matteo Bertini, Victoria Delgado, Arnold C.T. Ng, Dominique Auger, Tomasz G Witkowski, Imad A Younis, Bernies van der Hiel, Martin J Schalij, Jeroen J Bax
Journal: Circulation (2010)

Background: Although reduced myocardial uptake of 123-iodine meta-iodobenzylguanidine (123I-mIBG) is associated with poor outcomes in heart failure (HF) patients, it is unclear if it predicts respo...
OP0099 FUNCTIONAL MAPPING OF SYNOVIAL FIBROBLAST POPULATIONS IN HEALTH AND ARTHRITIC DISEASE: INSIGHTS INTO THE PATHOGENIC REMODELING OF SYNOVIAL MICROENVIRONMENT
Authors: D. Konstantopoulos, C. Tzaferis, M. Sakkou, A. Liakos, M. Lavigne, D. Karamitros, M. Fousteri, M. Armaka, G. Kollias
Journal: Annals of the Rheumatic Diseases (2020)

Background: Our previous studies highlighted the fundamental in vivo role of synovial fibroblasts (SFs) in TNF-mediated murine chronic arthritis 1,2 and recent findings identified different SF identities based on their transcriptomic profiles with distinct contributions in acute, autoimmunity-based, murine arthritis 3 . Objectives: In this study, we focus on delineating the map of SF subpopulations in healthy joint and in the course of arthritic disease and the underlying regulatory networks functioning towards pathogenicity. Methods: Sorted single cell suspensions (CD45-, Pdpl+) and their fragmented nuclei from synovial joints of WT, early and late arthritic hTNFtg mice were processed for scRNAseq and scATAC employing a droplet-based technology (10x Genomics). To define the transcriptional and epigenetic signatures originating from the two different assays, we developed an integrative analysis pipeline based on the Seurat software package (v3.1). Meta-analysis of previously reported data of K/BxN serum transfer of arthritis was employed to define commonalities and differences in SF subsets among murine modelled disease. Results: The transition from healthy to chronically affected synovial microenvironment (SME) due to overexpression of hTNF is characterized by a dynamic transformation of SF clusters. The Lining arthritic Thy1 low synovial layer (L-SFs) is hyper-populated while Sub-Lining Thy1 high SF clusters (SL-SFs) are remodeled towards catabolic and inflammatory phenotypes compared to naïve SF organization pattern. Interestingly, trajectory analysis revealed that the SL clusters, which normally exhibit a gradual developmental-like process towards different profiles, differentially change during disease. We identified that the previously reported proliferating SL cluster is absent in healthy synovium, dominates mainly in early stages of chronic arthritis and it is closely related to the L-SFs. Mapping of the gene regulatory networks by RNAseq was supported by scATAC analysis. Similarly, meta-analysis of SF profiles derived from naïve and the K/BxN-serum–treated mice showed significant differences, possibly reflecting the phenotypes of the two established models of arthritis. Conclusion: Our approach unravels for the first time the regulatory heterogeneity and gene expression profiling of SF subpopulations in normal synovium, and reveals deep biological insights of the functional re-organization of SME during development of disease. It further identifies the common and divergent features of the different subtypes of murine arthritis that may well reflect the diversity of RA subtypes and the response to therapies. References: [1]Armaka et al; J Exp Med (2008): 205(2):331-7. [2]Armaka et al; Nat Commun (2018): 9(1):618. [3]Croft et al; Nature (2019): 570(7760):246-251. Disclosure of Interests: None declared