tbuckley/cabot-search huggingface dataset:
A Handbook of Medical Climatology, Embodying its Principles and Therapeutic Application, with Scientific Data of the Chief Health Resorts of the World.
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiometabolic multimorbidity and depression in adults aged 45 years and older in China: longitudinal findings from the China Health and Retirement Longitudinal Study
Authors: Zi-Ting Huang, Gui-Ying Cao, Shan-Shan Yao, Zi-Shuo Chen, Yong-Hua Hu, Beibei Xu
Journal: The Lancet (2019)
Alk3, a BMP Type I Receptor Is Required for the Induction of Hepatic Hepcidin Gene Expression by Interleukin-6
Authors: Andrea U. Steinbicker, Claire Mayeur, Lisa K. Lohmeyer, Patricio Leyton, Sonya M. Kao, Alexandra E. Pappas, Rita Nobre, Randall T. Peterson, Donald B. Bloch, Paul B. Yu, Kenneth D. Bloch
Journal: Blood (2011)
Individualizing Revascularization Strategy for Diabetic Patients With Multivessel Coronary Disease
Authors: Mohammed Qintar, Karin H. Humphries, Julie E. Park, Suzanne V. Arnold, Yuanyuan Tang, Phillip Jones, Adam C. Salisbury, Faraz Kureshi, Michael E. Farkouh, Valentin Fuster, David J. Cohen, John A. Spertus
Journal: Journal of the American College of Cardiology (2019)
Inter-Observer Discordance With The Diagnosis Of Myelodysplastic Syndromes With Less Than 5% Bone Marrow Blasts: Unilineage Vs Multilineage Dysplasia and Reproducibility Of The Threshold Of 2% Blasts
Authors: Patricia Font, Javier Loscertales, Carlos Soto, Pilar Ricard, Carolina Muñoz Novas, Estela Martin-Clavero, Montserrat Lopez-Rubio, Luis Garcia-Alonso, Marta Callejas, Alfredo Bermejo, Celina Benavente, Monica Ballesteros, Teresa Cedena, María Calbacho, Raquel Urbina, Jesus Villarrubia, Ana Villegas
Journal: Blood (2013)
Natural-Killer Cell Cytotoxicity and Interleukin-2R As a Relevant Marker for Diagnosis of Secondary Hemophagocytic Lymphohistiocytosis in Adult Patients: The Results of Prospective Phase II Observational Study
Authors: Jae-Ho Yoon, Ki Hyun Park, Seug Yun Yoon, GI June MIN, Sung-Soo Park, Young-Woo Jeon, Sung-Eun Lee, Byung Sik Cho, Ki-Seong Eom, Yoo-Jin Kim, Seok Lee, Hee-Je Kim, Chang-Ki Min, Seok-Goo Cho, Dong-Wook Kim, Jong-Wook Lee, Eun-Jee Oh
Journal: Blood (2018)
High Neuropilin-1 Expression in Acute Myeloid Leukemia Is Mainly Associated with Monocytic Subtypes and Extramedullary Invasion
Authors: Yasser H ElNahass, Mohamed Abdel Mooti Samra, Omar A Fahmy, Fatma A Elrefaey, Soad Eltokhy, Hossam K Mahmoud
Journal: Blood (2018)
Opiate and Benzodiazepine Use during Hospitalization for Hematopoietic Stem Cell Transplantation (HSCT) Is Associated with Adverse Health Related Outcomes
Authors: Madiha Iqbal, Aaron C. Spaulding, Salman Ahmed, Prachi Jani, Chanel Wood, Shehzad Niazi, Rami Manochakian, Aneel Paulus, Ernesto Ayala, Mohamed A Kharfan-Dabaja, Vivek Roy, Asher A. Chanan-Khan, Sikander Ailawadhi, Taimur Sher
Journal: Blood (2018)
Gain-of-Function ADAMTS13 Variants Resistant to Anti-ADAMTS13 Autoantibody Inhibition: A Potential Novel Therapy for Acquired Autoimmune Thrombotic Thrombocytopenic Purpura
Authors: Cui Jian, Juan (Jenny) Xiao, Lingjie Gong, Christopher G. Skipwith, Sheng-Yu Jin, Hau C. Kwaan, X. Long Zheng
Journal: Blood (2011)
Public-Access Defibrillation in Japan
Authors: Nicole Karam, Xavier Jouven, Eloi Marijon
Journal: New England Journal of Medicine (2017)

To the Editor: In their study of the effect of public-access defibrillation on outcomes after out-of-hospital cardiac arrest in Japan, Kitamura et al. (Oct.27 issue) 1 found an improved survival rate when a publicly accessible automated external defibrillator (AED) was used in the field.However, the frequency of AED use by bystanders before the arrival of emergency medical service (EMS) personnel remained very poor (approximately 2% of witnessed arrests of cardiac origin).As compared with patients who did not receive public-access defibrillation, those who did had nearly twice the rate of cardiopulmonary resuscitation (CPR) (99.4% vs. 51.3%,P<0.001), and the bystanders required dispatcher instructions less frequently during CPR.These findings suggest that patients who received public-access defibrillation were treated by trained bystanders, who were aware of the importance of CPR and of how to perform it.The higher survival rate observed in this group highlights the importance of education, which most probably improved the rates of both public-access AED use and bystander CPR.In addition to AED use, bystander education constitutes the other component of any public-access defibrillation program 2,3 and must be a priority.
Abstract 148: Neonatal Mouse Heart Regeneration is Dependent on Mononuclear Diploid Cardiomyocytes and Paracrine IGF2 Signaling
Authors: Hua Shen, Michaela Patterson, Peiheng Gan, Henry M Sucov
Journal: Circulation Research (2019)

In normal mice, injury to the newborn heart is efficiently regenerated, but this capacity is lost by one week after birth when most cardiomyocytes have become post-mitotic. Concurrently during the first week, most cardiomyocytes become polyploid. Despite this temporal association, the relation of polyploidization to neonatal heart regeneration has not been adequately examined. In this study, we find that IGF2, an important mitogenic factor in heart development, is required to support neonatal mouse heart regeneration. Following injury on postnatal day 1, absence of IGF2 abolished injury-induced cell cycle entry (as indicated by phospho-histone H3 staining) during the early part of the first postnatal week, when cardiomyocytes are still mononuclear and diploid. Consequently, regeneration failed despite the later presence of additional activities that support robust cell cycle entry 7 days following injury, a time when most cardiomyocytes are polyploid and no longer able to complete cytokinesis. IGF2 originates from the endocardium/endothelium lineage and is transduced by the insulin receptor; both features distinguish the action of IGF2 in neonatal heart regeneration from that in embryonic heart development. Regeneration in injured Igf2-deficient neonates was rescued by three different contexts that elevate the percentage of mononuclear diploid cardiomyocytes beyond postnatal day 7. Thus, IGF2 is the primary paracrine-acting mitogen for heart regeneration during the early postnatal period, and IGF2-deficiency unmasks the dependence of this process on proliferation-competent mononuclear diploid cardiomyocytes.
Single-Cell Analysis of the Transcriptional Response in AML Patients Treated with BET-Inhibitors
Authors: Sophia Miliara, Bogumil Kaczkowski, Takahiro Suzuki, Huthayfa Mujahed, Maasaki Furuno, Satoshi Takizawa, Harukazu Suzuki, Takahiro Arakawa, Soren Lehmann, Andreas Lennartsson, Erik Arner
Journal: Blood (2018)
Comprehensive Genomic Analysis Identified Acute Lymphoblastic Leukemia in Down Syndrome Was Highly Heterogeneous with the High Prevalence of Ph-like Signature
Authors: Yasuo Kubota, Kumiko Uryu, Tatsuya Ito, Masafumi Seki, Tomoya Isobe, Tsutomu Toki, Kenichi Yoshida, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, MItsuteru Hiwatari, Satoru Miyano, Akira Oka, Seishi Ogawa, Kiminori Terui, Atsushi Sato, Etsuro Ito, Junko Takita
Journal: Blood (2018)
Neuroblastoma differentiation is regulated by cooperation of the RET and TRKA signaling pathways
Authors: Fei Xu, Sue Dubman, Himanso Sahni, Sharon Settnek, Harris Johnson, Ajay Gupta, Dana Zhang, Johnita Beasley, Sherri De Coronado, Ulli Wagner, Kevin Rosso, Clint Malone, Dinah Singer, Cheryl Marks, Betty Tarnowski, Ken Buetow
Journal: Cancer Research (2004)

4804  The Mouse Models of Human Cancers Consortium (MMHCC) is a collaborative program designed to derive and characterize mouse models of human malignancies. To enhance information and resource exchange among the MMHCC investigators and other cancer research scientists, the NCI Center for Bioinformatics (NCICB, http://ncicb.nci.nih.gov/) has developed web-based resources that are freely available to the cancer research community. These resources include a website (http://emice.nci.nih.gov) and databases for cancer models (http://cancermodels.nci.nih.gov) and cancer images (http://cancerimages.nci.nih.gov). The emice website describes mouse models for human cancer, providing background information on human cancer and a general overview of cancer incidence, disease etiology, current methods for diagnosis and treatment, molecular alterations, and existing rodent models of human cancer listed by organ site. Furthermore, this website contains links to recent publications of mouse models, offers learning and communication tools, catalogs research resources, and provides information about the MMHCC, its organization and activities. The cancer models database provides information about rodent models for cancer, including phenotypic and genetic descriptions of models, histopathology, derived cell lines, images, gene expression data, therapeutic approaches and publications. Users can query or submit the database by model name, species, tumor sites, therapeutic drugs, and other criteria. Some of the models in the cancer model databases are available to all members of the scientific community through the MMHCC Repository (http://mouse.ncifcrf.gov/). The cancer images database is being developed to host human and rodent cancer images with various modalities such as histology, MRI, CT, PET/SPECT and optical imaging. Users can retrieve images and image annotations including species, tissue, gender, diagnosis, and image dimensions. The images are displayed in a viewer with zoom capabilities. These resources are built using controlled vocabularies and are inter-linked with each other. They are also linked with other NCICB databases and outside resources. Together the emice, cancer models and cancer images sites provide comprehensive information from the level of molecular biology all the way through pre-clinical trials using mouse models of human cancer.
Abstract 829: Endothelial Estrogen Non-nuclear Signaling Plays a Key Role in Anti-remodeling Effects via cGMP Signaling in Failing Heart
Authors: Nobuaki Fukuma, Eiki Takimoto, Kazutaka Ueda, Pangyen Liu, Yuxin Li, Kensuke Noma, Yukio Hiroi, James K Liao, Issei Komuro
Journal: Circulation Research (2019)

Background: Estrogen plays a significant role in cardiovascular benefits. As one of its beneficial pathways, ERα non-nuclear signaling is known to be protective for the vascular system, but its role for cardiac remodeling is unknown thus far. We previously reported cGMP pathways are one of the critical therapeutic targets for heart failure and ERα non-nuclear signaling played a pivotal role in cardioprotection and was indispensable to the therapeutic efficacy of cGMP-PDE5 inhibition. However, it is still remaining undetermined which cells are playing the key role in cardioprotective effects via ERα non-nuclear signaling. Methods: We generated genetically modified mouse lacking ERα in cardiomyocytes (ERα f/f /αMHC Cre/+ ) or endothelial cells (ERα f/f /Tie2 Cre/+ ) and assessed the effects of chronic pressure-overload (TAC) and the efficacy of PDE5 inhibitor (PDE5i) sildenafil after TAC. In addition, for the first time we generated endothelial cell specific genet-modified mouse lacking interactions between p85α and ERα which are critical for non-nuclear signaling (ERα KI/KI /Tie2 Cre/+ ). Cardiac functions were assessed for evaluating the effects of endothelial ERα non-nuclear singlaing to failing hearts. Results: Under physiological E2 status, PDE5i’s anti-remodeling effects after TAC were abrogated in ERα f/f /Tie2 Cre/+ (FS(%) ± SEM with vs without PDE5i 28.16 ± 3.43 vs 31.87 ± 2.30) but not in ERα f/f /αMHC Cre/+ (FS(%) ± SEM with PDE5i vs without PDE5i 54.57 ± 3.418 vs 43.3 ± 1.21) consistent with hemodynamic analysis. Assessment with ERα KI/KI /Tie2 Cre/+ showed decreased cardiac functions even with physiological E2. Hemodynamic analysis also supported the cardioprotective effects of ERα non-nuclear signaling in endothelial cells. Conclusion: ERα non-nuclear reaction in endothelial cells plays an important role in cardio-protective mechanism, and endothelial estrogen signals are indispensable to the therapeutic efficacy of cGMP-PDE5 inhibition. Our results clarified one of the cardioprotective signals of estrogen and highlighted the new strategy for heart failure treatment.
Mitochondrial fragmentation limits NK cell-based tumor immunosurveillance
Authors: Xiaohu Zheng, Yeben Qian, Binqing Fu, Defeng Jiao, Yong Jiang, Peng Chen, Yiqing Shen, Huafeng Zhang, Rui Sun, Zhigang Tian, Haiming Wei
Journal: Nature Immunology (2019)
Decreased Apoptosis in Bone Marrow of Pediatric Patients After HLA-Identical Stem Cell Transplantation for African Sickle Cell Anemia
Authors: Antonella Isgrò, Marco Marziali, Pietro Sodani, Javid Gaziev, Daniela Fraboni, Katia Paciaroni, Maria Domenica Simone, Gioia De Angelis, Cecilia Alfieri, Cristiano Gallucci, Andrea Roveda, Fabio Torelli, Luisa Cardarelli, Michela Ribersani, Guido Lucarelli
Journal: Blood (2012)
Pan-viral serology implicates enteroviruses in acute flaccid myelitis
Authors: Ryan D. Schubert, Isobel A. Hawes, Prashanth S. Ramachandran, Akshaya Ramesh, Emily D. Crawford, John E. Pak, Wesley Wu, Carly K. Cheung, Brian D. O’Donovan, Cristina M. Tato, Amy Lyden, Michelle Tan, Rene Sit, Gavin M. Sowa, Hannah A. Sample, Kelsey C. Zorn, Debarko Banerji, Lillian M. Khan, Riley Bove, Stephen L. Hauser, Amy A. Gelfand, Bethany L. Johnson-Kerner, Kendall Nash, Kalpathy S. Krishnamoorthy, Tanuja Chitnis, Joy Z. Ding, Hugh J. McMillan, Charles Y. Chiu, Benjamin Briggs, Carol A. Glaser, Cynthia Yen, Victoria Chu, Debra A. Wadford, Samuel R. Dominguez, Terry Fei Fan Ng, Rachel L. Marine, Adriana S. Lopez, W. Allan Nix, Ariane Soldatos, Mark P. Gorman, Leslie Benson, Kevin Messacar, Jennifer L. Konopka-Anstadt, M. Steven Oberste, Joseph L. DeRisi, Michael R. Wilson
Journal: Nature Medicine (2019)
Single Center Retrospective Study of Essential Thrombocythaemia Diagnosed Patients Treated with Interferon - Benefit and Tolerability
Authors: Joana Desterro, Donal P McLornan, Natalia Curto-Garcia, Jennifer O'Sullivan, Kordasti Shahram, Claire Woodley, Yvonne Francis, Deepti Radia, Claire N. Harrison
Journal: Blood (2018)
Abstract 321: RBFOX2 is critical for maintaining alternative polyadenylation patterns in cardiomyoblasts
Authors: Jun Cao, KarryAnne Belanger, Ela Jaworski, Kempaiah Rayavara, Curtis Nutter, Ping Ji, Nathan Elrod, Sunil Verma, Steven Widen, Eric J Wagner, Nisha Garg, Andrew L Routh, Muge Kuyumcu-Martinez
Journal: Circulation Research (2019)

Background: The RNA binding protein RBFOX2 is implicated in human heart diseases. However, RBFOX2-regulated RNA networks are not well defined. RBFOX2 has a well-characterized role in alternative splicing (AS) while accumulating evidence suggests that RBFOX2 may also have a role in alternative polyadenylation (APA). Recent studies showed that RBFOX2 binds to regions close to poly(A) sites in the 3’UTR of pre-mRNAs. In addition, RBFOX2 binds to the cleavage and polyadenylation specificity factors. Therefore, we aimed to determine whether RBFOX2 has a role in regulating APA. Method: We employed poly(A)click sequencing (PAC-seq) and DPAC (Differential Poly(A) Cluster analysis) computational pipeline to identify differential poly(A) usage and mRNA abundance. We also used nanopore sequencing to identify different spliced variants and the coordinated AS and APA events. Results: We report that knockdown of RBFOX2 in embryonic rat heart derived cells leads to altered alternative polyadenylation (APA) of hundreds of genes. RBFOX2-mediated APA changes impacted both mRNA levels and generation of different gene isoforms. Nanopore sequencing identified full-length transcripts regulated by RBFOX2 and revealed RBFOX2-mediated isoform switches via both APA and AS in cardiac cells. Notably, RBFOX2-regulated APA networks affect genes such as Tpm1 and Tnnt1 involved in cardiac contractility. Identification of RBFOX2-regulated RNA networks provides novel insights into the pathogenesis of heart diseases in which RBFOX2 is involved and pave the way for designing therapeutics. Conclusions: RBFOX2 regulates alternative polyadenylation via splicing dependent and independent mechanisms. RBFOX2-mediated APA affects mRNA levels of contractile genes.
Abstract 856: Mitochondrial Protein Kinase B (akt) Translocation Mediates Insulin-stimulated Cardiac Glucose Oxidation
Authors: Qutuba G Karwi, Cory S Wagg, Tariq R Altamimi, Gary D Lopaschuk
Journal: Circulation Research (2019)

Introduction: Insulin stimulates glucose oxidation, an effect which is associated with simulating pyruvate dehydrogenase (PDH). However, how the insulin signal is transduced from the cell membrane to the mitochondria to stimulate PDH is not known. Protein kinase B (Akt), protein kinase C-delta (PKCδ) and glycogen synthase kinase-3beta (GSK-3β) are main components of the cytosolic insulin signalling pathway and it has been suggested that they can be translocated to the mitochondria following insulin receptor activation in noncardiac tissue. Therefore, we investigated whether any of these kinases has a role mediated cardiac insulin-stimulated glucose oxidation in the heart. Methods and Results: Male and female C57BL/6 mice were anesthetized and hearts were collected and perfused in the isolated working heart mode. Hearts were perfused with [5- 3 H] glucose and [U- 14 C] glucose to simultaneously measure glycolysis and glucose oxidation rates, respectively, in the presence and absence of insulin. Insulin enhanced the phosphorylation and translocation of Akt Ser473 , PKCδ Tyr311 and GSK-3β Ser9 to the cardiac mitochondria along with enhancing PDH activity by decreasing its phosphorylation. Pharmacological inhibition of Akt using AktiVIII completely abolish the stimulatory effect of insulin on cardiac glucose oxidation rates (354 ± 145 vs 2307 ± 185 nmol. g dry wt -1 . min -1 in vehicle-treated hearts, p&lt;0.05). However, pharmacological inhibition of either PKCδ or GSK-3β using Bisindolylmaleimide I or 3F8, respectively, did not have a significant effect on insulin-stimulated glucose oxidation rates. None of the pharmacological inhibitors had any significant effect on cardiac glycolysis. Conclusion: Insulin mediates its stimulatory effect on cardiac glucose oxidation via a mechanism which involve the activation and translocation of Akt to the mitochondria.
A feasibility trial of Acetic acid-targeted Biopsies versus nontargeted quadrantic biopsies during BArrett’s surveillance: the ABBA trial
Authors: Gaius Longcroft-Wheaton, Carole Fogg, Fergus Chedgy, Kesavan Kandiah, Lisa Murray, Ann Dewey, Hugh Barr, Bernie Higgins, David Poller, Janusz Jankowski, John DeCaestecker, Pradeep Bhandari
Journal: Endoscopy (2019)

The aims of this study were to compare neoplasia detection rates for nontargeted biopsies (Seattle protocol) versus acetic acid-targeted biopsies (Portsmouth protocol) during Barrett's surveillance and to explore feasibility, patient/clinician experience, acceptance, and barriers/enablers to study participation and implementation of the acetic acid technique.This was a mixed-methods feasibility study including a pilot multicenter, randomized, crossover trial with qualitative interviews. Patients under Barrett's surveillance with no history of neoplasia were included. Patients underwent two endoscopies, one with each protocol, 8 weeks apart. Outcomes included recruitment and retention rates, neoplasia yield, and number of biopsies.200 patients were recruited from 6 centers, and 174 (87.0 %) underwent both procedures. Neoplasia prevalence was 4.7 % (9/192). High grade dysplasia and cancer were detected with both protocols. Five low grade dysplasias were detected (two with acetic acid, four with nontargeted biopsies; one lesion was detected with both techniques). A total of 2139 biopsies were taken in the nontargeted arm and 226 in the acetic acid arm. Both patients and clinicians found the acetic acid technique acceptable. Based on these data, a noninferiority, tandem, crossover trial would require an estimated 2828 patients.We demonstrated the feasibility of performing a crossover endoscopy trial in Barrett's surveillance. Low neoplasia yield makes this design necessary and qualitative results demonstrated patient and clinician acceptance. The reduced numbers of biopsies suggest that the acetic acid technique could result in cost savings, providing the lack of missed pathology can be proven in a fully powered definitive trial.
Risk of Adverse Events Is Similar in Patients (Pts) Who Did or Did Not Achieve Hemoglobin (Hb) Above 12g/dL in a Phase 3 Clinical Trial of Darbepoetin alfa (DA) Administered Weekly (QW) or Every 3 Weeks (Q3W) in Anemic Cancer Pts Receiving Chemotherapy.
Authors: Heinz Ludwig, Jean-Luc Canon, Johan Vansteenkiste, Lisa Hamilton, Tamás Suto
Journal: Blood (2007)
Evaluation of Elderly Patients with Hematological Malignancies By Two Different Geriatric Risk Scoring Systems: G8 and Flemish Version of the Triage Risk Screening Tool (fTRST)
Authors: Erden Atilla, Merih Yalciner, Ozlem Kilic, Nurhayat Muftuoglu, Pinar Ataca Atilla, Sinem Civriz Bozdag, Selami Kocak Toprak, Meltem Kurt Yuksel, Muhit Özcan, Gunhan Gurman, Osman Ilhan
Journal: Blood (2018)
Evaluation Of CD33 Expression and Functional Analysis Of The CD33/CD3 Bispecific BiTE® Antibody AMG 330 In Primary AML Samples
Authors: Christina Krupka, Peter Kufer, Roman Kischel, Gerhard Zugmaier, Jan Boegeholz, Thomas Köhnke, Felix S Lichtenegger, Stephanie Schneider, Klaus H. Metzeler, Michael Fiegl, Karsten Spiekermann, Patrick Baeuerle, Wolfgang Hiddemann, Gert Riethmüller, Marion Subklewe
Journal: Blood (2013)