tbuckley/cabot-search huggingface dataset:
THU0430 Description and prognosis factors of systemic sclerosis-associated interstitial lung disease outcome on serial hrct
Authors: A. Forestier, N. le gouellec, A. duhamel, G. kramer, T. perez, V. sobanski, S. morell dubois, M. lambert, P.-Y. hatron, E. hachulla, H. behal, R. matran, D. launay, M. remy jardin
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Interstitial lung disease (ILD) is a leading cause of morbidity and mortality in systemic sclerosis (SSc). While factors associated with the presence of ILD in SSc (SSc-ILD) are identified, those associated with ILD outcome are still debated and studies assessing the evolution of SSc-ILD on HRCT are scarce. Yet, it is important to identify patients at risk of SSc-ILD worsening because those patients are thought to benefit the most from immunosuppressants. <h3>Objectives</h3> Thus, the aims of our study were: to describe the evolution of HRCT extension and patterns of SSc-ILD, to identify baseline prognosis factors of ILD outcome on serial HRCT and to investigate whether the evolution of pulmonary function tests (PFTs) parameters correlated with the evolution on HRCT. <h3>Methods</h3> We included 58 SSc patients with HRCT proven ILD, with at least two available HRCT, and collected clinical, biological data and PFT at baseline. We collected all HRCT and PFTs available during follow-up. We modelized PFTs and HRCT evolution using linear mixed model with random coefficients. <h3>Results</h3> Mean ILD extension at baseline was 32.3%±28.7%. During a mean follow-up of 5.3±4.9 years, we found a significant mean progression of ILD extension of 0.92%±0.36% per year (p=0.018). Male sex, anti-topoisomerase 1 antibodies, diffuse cutaneous SSc were associated with faster progression of ILD extension. Limited ILD according to Goh <i>et al.</i> staging system, and a coarseness score at zero (meaning 100% of ground glass opacification) were associated with a faster progression of ILD extension. We also found a significant decline of DLCO, FVC and TLC during follow-up. There was a significant correlation between the progression of ILD extension on HRCT and the decline of DLCO, but not with the evolution of FVC. <h3>Conclusions</h3> Male patients, patients with diffuse SSc/antitopoisomerase 1, patients with less severe and less extensive ILD at baseline were more likely to experiment a faster progression of ILD extension on serial HRCT. To our knowledge, this is the first study that clearly highlighted the diffuse form of SSc/presence of antitopoisomerase 1 as a worsening factor of SSc-ILD on HRCT. FVC might not be the best mirror of ILD progression while DLCO significantly correlated with change in ILD extension. Our study helps to define the profile of patients who are going to experience a progression of ILD on HRCT during follow up. <h3>Disclosure of Interest</h3> None declared
The clinical impact of<i>Pseudomonas aeruginosa</i>eradication in bronchiectasis in a Dutch referral centre
Authors: Angelina Pieters, Marleen Bakker, Rogier A.S. Hoek, Josje Altenburg, Mireille van Westreenen, Joachim G.J.V. Aerts, Menno M. van der Eerden
Journal: European Respiratory Journal (2019)

<b>An antibiotic approach directed at eradication of a new isolate of <i>Pseudomonas aeruginosa</i> can result in a significant reduction in exacerbation frequency in bronchiectasis patients</b>http://ow.ly/L1Zl30nv1WS
Abstract 18953: Performing CPR on a Beating Heart Alters Mean AOP
Authors: Giulia Di Tomaso, George Bratinov, Ralph Wijshoff, Dawn Jorgenson, Marc Fuller, Todd J Kilbaugh, Lance B Becker, Joshua W Lampe
Journal: Circulation (2017)

Introduction: It is recommended that bystanders witnessing the sudden collapse of an individual should provide cardiopulmonary resuscitation (CPR) whilst waiting for the emergency medical services. As the presence of pulse might not be assessed correctly, it is possible that a bystander might perform CPR on a beating heart. Although potentially important to the patient’s outcome, the hemodynamic changes caused by performing CPR on a beating heart have not been extensively investigated. Hypothesis: Aim of this study is to investigate changes in mean arterial blood pressure (AOP) following CPR in animals with a beating heart. Methods: Prospective laboratory investigation using an established porcine model with instrumentation for measurement of hemodynamic variables, vital organ blood flow and blood gases. Animals (n=5) were anesthetized and mechanically ventilated on a mixture of room air and titrated isoflurane (≈1.0% to 2.5%). CPR at 30:2 compressions over breaths was performed for 2 minutes followed by ...
The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons
Authors: Brian P. Daniels, Sigal B. Kofman, Julian R. Smith, Geoffrey T. Norris, Annelise G. Snyder, Joseph P. Kolb, Xia Gao, Jason W. Locasale, Jennifer Martinez, Michael Gale, Yueh-Ming Loo, Andrew Oberst
Journal: Immunity (2019)
AB0341 Metatarsophalangeal joints have more erosions in patients with rheumatoid arthritis
Authors: M. Alagoz, E. Emlakcioglu, A.C. Tunc, A. Kucuk, T. Gulen, M. Kocabas, R. Tunc
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised by destruction of synovial joints, especially in the hand and feet, leading to severe disability and premature mortality. The erosions seen in RA differentiate it from other rheumatological diseases. <h3>Objectives</h3> The aim of the study was to evaluate the relationship between attack frequency and erosions seen in RA. <h3>Methods</h3> Forty-four patients according to 2010 ACR/EULAR Classification Criteria for RA were included into the study. Involved joints and number of attacks were recorded. The X-rays of the involved joints were assessed on admission and after 3 months in terms of joint erosion as a blinded manner. Comparison of erosions were calculated by chi-square. <h3>Results</h3> Kappa value of intra-observer agreement of reading of x-ray films was 0.68. Erosions were detected in 16 of 44 patients with RA. The Ratios of erosion in joints with more than 10 attacks were different according to involved joints. The ratios of erosions were 10% for metacarpophalangeal (MCP), 8% for proximal interphalangeal (PIP), 0% for knee, 5% for ankle and 69% for metatarsophalangeal (MTP) joints. When compared MTP joints with MCP, PIP and wrist joints, it was seen that the erosion rate was higher in MTP joints than the other joints (p&lt;0,01). Knee and ankle joints were combined as a single group and compared with MTP joints in terms of erosion. It was seen that the erosions in the MTP joints were significantly higher than the erosions in the knee and ankle joints (p&lt;0,01). <h3>Conclusions</h3> In RA, the erosion ratio of MTP joints was significantly higher than seen in MCP, PIP and wrist joints. On the other hand the erosion rate in knee and ankle joints was rare. These results show us the erosion in MTP joints may not related to mechanical overload. Therefore foot imaging with x-ray may be important in the folllowing of patients with RA. In addition existence of false positive erosions in MTP joints of healthy people should be studied. <h3>Disclosure of Interest</h3> None declared
THU0486 The vitamin d receptor expression in skeletal muscle of women with distal radius fracture
Authors: H.S. Gong, K. Kim
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> A distal radius fracture (DRF) is the most common upper extremity fracture in old women. Since DRFs typically occur earlier than hip fractures by an average of 15 years, they can reflect early changes of bone such as osteoporosis and muscle frailty for instance, the loss of muscle mass. <h3>Objectives</h3> We aimed to evaluate the relationship between the vitamin D receptor (VDR) expression in the muscle cell and the muscle mass in women with a DRF. <h3>Methods</h3> This research was conducted as a part of the Study on Ageing Radial fracture Cohort (SARCO) which is an ongoing longitudinal, population-based cohort investigation of patients with a DRF which began in November 2015. For the current study, we prospectively recruited 45 women over 50 years of age (mean age, 66 years) with DRF and acquired biopsy of the forearm flexor muscle. The muscle cross-sectional area (CSA) and VDR expression were measured using immunohistochemistry staining. The clinical parameters including grip strength, gait speed, body mass index (BMI), bone mineral density (BMD), and serum vitamin D levels were compared between patients grouped by appendicular lean mass index and were correlated with the VDR expression. <h3>Results</h3> Twelve patients (27%) showed a decreased appendicular lean mass index, less than the cut-off value of 5.4 kg/m<sup>2</sup> which was suggested by the Asian Working Group for Sarcopenia. Patients with a low appendicular lean mass index had significantly lower muscle CSA (p=0.037), but a higher VDR expression (p=0.045) than those with higher indices. VDR expression was negatively correlated with BMI (<i>r</i>=−0.417, p=0.004) and appendicular lean mass index (<i>r</i>=−0.316, p=0.044). <h3>Conclusions</h3> DRF patients with low appendicular lean mass index presented high VDR expression and low CSA in forearm muscle cells. This suggests that the VDR expression might be up-regulated in the attempt to compensate for the decreasing muscle mass. Further studies are necessary to explore the role of VDR in the progression of sarcopenia. <h3>References</h3> [1] Ceglia L, Harris SS. Vitamin D and its role in skeletal muscle. Calcif Tissue Int2013;92(2):151–162. [2] Bischoff-Ferrari H, Borchers M, Gudat F, Dürmüller U, Stähelin H, Dick W. Vitamin D receptor expression in human muscle tissue decreases with age. J Bone Miner Res2004;19(2):265–269. [3] Frontera WR, Reid KF, Phillips EM, Krivickas LS, Hughes VA, Roubenoff R, Fielding RA. Muscle fiber size and function in elderly humans: a longitudinal study. J Appl Physiol2008;105(2):637–642. <h3>Disclosure of Interest</h3> None declared
Presentation Patterns and Management Strategies for Central Nervous System Involvement in Multiple Myeloma: A Systematic Review of Literature
Authors: Jemin Aby Jose, Insija Ilyas Selene, Mustafa Nadeem Malik, Anum Qureshi, Abdul Rafae, Hafiz Muhammad Fazeel, Muhammad Abu Zar, Ahmad Kamal, Saad Ullah Malik, Ceren Durer, Seren Durer, Faiza Jamil, Madeeha Shafqat, Muhammad Usman, Giyth Mithim Mahdi, Faiz Anwer
Journal: Blood (2018)
Adaptive Landscapes in the Age of Synthetic Biology
Authors: Xiao Yi, Antony M Dean
Journal: Molecular Biology and Evolution (2019)

For nearly a century adaptive landscapes have provided overviews of the evolutionary process and yet they remain metaphors. We redefine adaptive landscapes in terms of biological processes rather than descriptive phenomenology. We focus on the underlying mechanisms that generate emergent properties such as epistasis, dominance, trade-offs and adaptive peaks. We illustrate the utility of landscapes in predicting the course of adaptation and the distribution of fitness effects. We abandon aged arguments concerning landscape ruggedness in favor of empirically determining landscape architecture. In so doing, we transform the landscape metaphor into a scientific framework within which causal hypotheses can be tested.
Potential Unintended Effects of Medicare’s Bundled Payments for Care Improvement Program
Authors: William B. Weeks, Elliott S. Fisher
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THU0541 The effect of physical therapy on clinical and quality of life in chronic neck pain patients:a randomised controlled trial
Authors: N. &Scedil;ahin, M. &Scedil;ahin
Journal: Annals of the Rheumatic Diseases (2018)

Background  In the treatment of chronic neck pain (CNP), education, medical treatment, exercise and physical therapy (PT) modalities are in place. However, there are not enough studies on the efficacy of PT modalities in CNP  Objectives  To evaluate the effectiveness of the addiction of PT modalities to exercise and medical treatment in relieving pain and improving the funcitonal status of patient with CNP  Methods  80 patients with CNP were included in a randomised, controlled trial. Patients were assigned in two groups randomly. Treatment group (TG) recieved convantional PT (hot pack (HP), ultrasound (US), Transcutaneous Electrical Nerve Stimulation (TENS)) treatment in addition.PT was applied ten sessions.HP treatment was applied in 20 min.US treatment was applied with 1,5watt/cm² dose and continuous type in 10 min.TENS treatment was applied with conventional type in 30 min. All patients were informed about correct posture and daily life activities. Both groups received home-based exercises program and analgesic medical treatment if it is necessary. Patients were evaluated before and after therapy and 3th month later by Visual Analogue Scale (VAS), cervical range of motion (ROM), Beck Depression Scale (BDS) and short form-36 (SF-36)  Results  In both groups there is significant improvement in VAS, cervical ROM, SF 36 and BDS after treatment (p  There is no significant difference between groups for VAS, SF-36 parameters and BDS before and after treatment (p>0.05). There was a significant improvement in VAS, SF-36 parameters and BDS in the TG compared with the CG at the end of therapy and 3 months post-treatment (p   Conclusions  Medical treatment and exercise with HP, US and TENS therapy was effective on both pain and disability during the treatment. This improvement keep on 3th month follow up. Also same improvement was seen on mood and life qualty. Exercise has better effects on after treatment, but these goods effects decrease on 3th month follow up. So we think physical medicine modalities should be used in CNP with disability  References  [1] Binder A.The diagnosis and treatment of nonspecific neck pain and whiplash.Eura Medicophys2007;43:79–89.  [2] Leaver AM, Refshauge KM, Maher CG, et al. Conservative interventions provide short-term relief for non-specific neck pain. J Physiother2010;56:73–84.  [3] Wang WTJ, Olson SL, Campbell AH, et al.Effectiveness of Physical Therapy for Patients with Neck Pain. A Individualized Approach Using a Clinical Decision-Making Algorithm. Am J Phys Med Rehabil2003;82:203–218.  Disclosure of Interest  None declared
THU0166 The diastolic dysfunction in patients with rheumatoid arthritis
Authors: L. Feiskhanova
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Rheumatoid arthritis is autoimmune rheumatic disease characterised by injury not only the joints but also other organs, including the heart. It is known that the presence of rheumatoid arthritis increases the risk of fatal cardiovascular complications by 1.5 times compared to the general population. <h3>Objectives</h3> to identify features of development of diastolic dysfunction in patients with rheumatoid arthritis. <h3>Methods</h3> we examined 180 patients with rheumatoid arthritis. The activity of disease was defined according to the scale of the DAS-28. By echocardiography in 101 patients (group 1) were identified diastolic dysfunction of the left or both ventricles and in 79 patients (group 2) it was absent. Both groups were matched for age and sex. We determined the following echocardiographic parameters: mitral E/A, tricuspid E/A, end-diastolic dimension of left ventricle. In addition to echocardiography, patients underwent the vectorcardiography with the assessment of electrophysiological parameters: the squares of loops P, QRS, T, maximum vector (MV), MV-azimuth and MV- ascent. To compare two independent groups on quantitative grounds used nonparametric methods, the rank correlation and Mann-Whitney test. Differences were considered to be valid when p&lt;0.05. <h3>Results</h3> when comparing the groups revealed that in the 1st group, DAS-28 was higher than in the 2nd (p&lt;0,05): 5,575<sup>5,17; 6,15</sup> and 5.32<sup>4,8; 5,8</sup> respectively. In the 1st group, the square of loop QRS and the MV- ascent directly correlated with E/A of mitral valve (p&lt;0.05), whereas in the 2nd group, we have established a direct relationship with end-diastolic dimension (p&lt;0.05). <h3>Conclusions</h3> the results indicate that increased activity of rheumatoid arthritis contributes to the development of diastolic dysfunction of the myocardium. In addition, the decrease in E/A observed in diastolic dysfunction, accompanied by electrophysiological remodelling and reduction in electrical activity of the myocardium of the left ventricle, diagnosed during registration of vectorcardiogram. Moreover, even in the absence of diastolic dysfunction, a tendency to its development in the presence of electrophysiological remodelling. This demonstrates the relationship between early electrophysiological, structural-geometric changes in patients with rheumatoid arthritis. Early diagnosis allows for timely start prevention of remodelling in patients with rheumatologic diseases. <h3>Disclosure of Interest</h3> None declared
Risk of Appendicitis in IgE-Mediated Allergy—Reply
Authors: Martin Salö, Lars Hagander, Pernilla Stenström
Journal: JAMA Pediatrics (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
THU0513 Is there a role of serum nesfatin-1 level in fibromyalgia?
Authors: B. Bilgici, Y. Akyol, Y. Ulus, S.S. Urkmez, O. Kuru
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Fibromyalgia (FM) is characterised by chronic widespread pain, sleep disturbances, affective disorders, fatigue, cognitive dysfunction, anxiety and depressive episodes and its pathogenesis is still unclear.<sup>1</sup> Nesfatin-1 is a recently identified anorexigenic hypothalamic polypeptide which plays role on mood, stress, sleep, anxiety, eating behaviour, and metabolic regulation.<sup>2, 3</sup> Serum level of nesfatin-1 may be associated with the physiopathology and clinical semptoms of FM. <h3>Objectives</h3> The aim of the present study was to compare serum nesfatin-1 level in patients with FM with healthy controls, and to investigate its relationship with demographic features and clinical parameters such as pain severity, disease activity, fatigue, emotional status, and sleep quality in FM patients. <h3>Methods</h3> Forty-six female patients with FM and 46 healthy female controls were included in the study. Demographic characteristics of participants were recorded. Severity of Pain by Visual Analogue Scale (VAS), disase activity by Fibromyalgia Impact Questionnaire (FIQ) were evaluated in patients with FM. Fatigue by Multidimensional Assesment of Fatigue (MAF), sleep quality by Pittsburgh Sleep Quality Index (PSQI), emotional status by Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) were performed in both groups. Serum nesfatin-1 concentrations were measured in all participants. <h3>Results</h3> Serum nesfatin-1 concentrations were significantly low in patients with FM compared to the healthy subjects (p&lt;0.05). When compared to the FM patients without anxiety, serum nesfatin-1 concentrations were significantly increased in FM patients with anxiety (p&lt;0.05). Serum nesfatin-1 concentrations were positive correlated with BAI scores in patients with FM (p&lt;0.05) whereas no statistically significant correlations were found between serum nesfatin-1 concentrations and age, BMI, and other clinical parameters in the patient and control group (p&gt;0.05). <h3>Conclusions</h3> According to the results of this study, it can be suggested that decreased nesfatin-1 plays a role in the FM pathogenesis and nesfatin-1 may mediate anxiety-related responses in FM patients. <h3>References</h3> [1] Talotta R, Bazzichi L, Di Franco M, Casale R, Batticciotto A, Gerardi MC, et al. One year in review 2017: fibromyalgia. Clin Exp Rheumatol2017;35:6–12. [2] Oh-I S, Shimizu H, Satoh T, Okada S, Adachi S, Inoue K, et al. Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature2006;443:709–12. [3] Aydin S. Multi-functional peptide hormone NUCB2/nesfatin-1. Endocrine2013;44:312–25. <h3>Disclosure of Interest</h3> None declared
SP0177 Quality of life at the workplace – how early interventions of health professionals can support people with rmds
Authors: E. Mosor
Journal: Annals of the Rheumatic Diseases (2018)

<h3></h3> It is widely acknowledged that work has huge impact on health and well-being. As people affected by rheumatic and musculoskeletal diseases (RMDs) often have problems in participating in work, they should be supported by the multidisciplinary health care team. Health professionals in rheumatology play an important role in early interventions to support people with RMDs at their work places. This presentation will set out to explore important issues which need to be addressed when enabling people with RMDs to stay employed or return to work from the perspective of health professionals in rheumatology. The presentation will focus on paid work, but also include unpaid work. With reference to ongoing clinical and research work in this field, the author will discuss possibilities and challenges in identifying work related problems, setting goals in a collaborative way, as well as providing different secondary and tertiary preventive strategies, interventions and workplace adaptations. By using a participatory multi-methods approach, facilitating self-management, evaluating and adapting work tasks and the environment, and providing ergonomic devices, people with RMDs can be supported. And as the right time point for doing something for health and more quality of life at the work place is now, some innovative, easy-to-transfer ideas for patients, health professionals and rheumatologists will also be presented. <h3>Disclosure of Interest</h3> None declared