tbuckley/cabot-search huggingface dataset:
How Big Data and High-Performance Computing Drive Brain Science
Authors: Shanyu Chen, Zhipeng He, Xinyin Han, Xiaoyu He, Ruilin Li, Haidong Zhu, Dan Zhao, Chuangchuang Dai, Yu Zhang, Zhonghua Lu, Xuebin Chi, Beifang Niu
Journal: Genomics Proteomics & Bioinformatics (2019)

Abstract Brain science accelerates the study of intelligence and behavior, contributes fundamental insights into human cognition, and offers prospective treatments for brain disease. Faced with the challenges posed by imaging technologies and deep learning computational models, big data and high-performance computing (HPC) play essential roles in studying brain function, brain diseases, and large-scale brain models or connectomes. We review the driving forces behind big data and HPC methods applied to brain science, including deep learning, powerful data analysis capabilities, and computational performance solutions, each of which can be used to improve diagnostic accuracy and research output. This work reinforces predictions that big data and HPC will continue to improve brain science by making ultrahigh-performance analysis possible, by improving data standardization and sharing, and by providing new neuromorphic insights.
Strong p53 Expression Is an Independent Predictor of Outcome in De Novo Diffuse Large B Cell Lymphoma (DLBCL) Treated with Either CHOP or CHOP-R.
Authors: Pedro Farinha, Laurie Sehn, Brian Skinnider, Lin Wu, Nancy Patten, Sim Truong, Joseph M. Connors, Randy D. Gascoyne
Journal: Blood (2006)
G-CSF Stimulates Expression of Non-Phosphorylated Stathmin (Oncoprotein, Op18) in Hematopoietic Stem Cells.
Authors: Heinrich Lannert, Thomas Able, Thomas Franz, Stefan Leicht, Patrick Wuchter, Angela Lenze, Volker Eckstein, Rainer Saffrich, Anthony D. Ho
Journal: Blood (2007)
Feedback Responses of the Pyrimidine Metabolism Network Mediate Resistance to Decitabine and 5-Azacytidine
Authors: Xiaorong Gu, Rita Tohme, Benjamin K. Tomlinson, Lisa Durkin, Caroline Schuerger, Asmaa M Zidan, Tomas Radivoyevitch, Hetty E. Carraway, Ronald Sobecks, Betty K. Hamilton, Alan Lichtin, MD, Jaroslaw P. Maciejewski, Yogenthiran Saunthararajah
Journal: Blood (2019)
Improved Post-Transplant Outcomes in Hematologic Malignancy Patients Undergoing Non-Myeloablative Hematopoietic Stem Cell Transplant (NMHSCT) Using a 400 cGy Total Body Irradiation (TBI) Dose with Fludarabine.
Authors: Ronald M. Sobecks, Karl S. Theil, Lisa Rybicki, Roger Macklis, Brad Pohlman, Steve Andresen, Stacey Brown, Elizabeth Kuczkowski, Kelly Cherni, Janet Baker, Laura Bernhard, Matt Kalaycio, Brian Bolwell
Journal: Blood (2005)
Von Willebrand Factor Cleaving Protease (ADAMTS-13) Antigen Levels Are Decreased in Patients with Heparin-Induced Thrombocytopenia.
Authors: Debra Hoppensteadt, Josephine Cunanan, Jeanine M. Walenga, Michael P. Ero, Walter P. Jeske, Rodger Bick, Jawed Fareed
Journal: Blood (2005)
Gender dysphoria: a question of informed consent
Authors: Julie Maxwell, Katherine Clyde, Lucy Griffin
Journal: BMJ (2019)

We welcome discussion around the treatment of children with gender dysphoria, particularly the concerns that have been raised regarding the puberty blockers study.1 Although the Health Research Authority’s investigation concluded that researchers did not veer from research norms, we are left with important questions over their use.

Gender dysphoric children and teens are experiencing a crisis of identity. Young people …
Assembly of the Prothrombinase Complex on Human Fibroblast Surface Is Enhanced by TSP1 and Leads to CTGF Upregulation by a Different Mechanism from the One Used by FXa and Thrombin.
Authors: Mario C. Rico, James J. Rough, Joanne M. Manns, Satya P. Kunapuli, Raul A. De La Cadena
Journal: Blood (2008)
The Unfolded Protein Response Is a Determinant of Disease Actvity in Waldenstrom’s Macroglobulinemia (WM).
Authors: Xavier Leleu, Lian Xu, Daniel D. Santos, Allen W. Ho, Zachary R. Hunter, Kelly O’Connor, Robert J. Manning, Olivier Tournilhac, Mariana Chemaly, Andrew R. Branagan, Christopher J. Patterson, Kenneth C. Anderson, Steven Treon
Journal: Blood (2005)
c-Myb Plays a Role InG2/M Cell Cycle Transition by Direct Regulation of Cyclin B1 Expression in Hematopoietic Cells.
Authors: Yuji Nakata, Susan Shetzline, Chizuko Sakashita, Anna Kalota, Andrzej Ptasznik, Yi Zhang, Stephen G. Emerson, Alan M. Gewirtz
Journal: Blood (2005)
Pediatric hepatic angiosarcoma treated with chemotherapy and partial hepatectomy: A case report.
Authors: Flavia Watusi Faria
Journal: Journal of Clinical Oncology (2013)

e21001 Background: Hepatic angiosarcoma is a high-grade malignant neoplasm, extremely rare in children and associated with a poor prognosis. It is reported in English language less than fifty cases in children between 2 months and 15- year-old at presentation. Due to the rarity of this tumor type, little is known about effective systemic therapy. Many diferent schedules have been reported, comprising surgery only, neoadjuvant chemotherapy, surgery wih adjuvant radiotherapy and hepatic transplantation. The median survival rate stays between 10 to 48 months, independently of the treatment chosen, with inconsistent results. Methods: retrospective medical records review. Objective: We present our experience wih a female 3-year-old child presenting wih a huge unressectable liver angiosarcoma at diagnosis, treated with neoadjuvant intensive chemotherapy based on ifosfamide, carboplatine and etoposide and right hepatectomy. The child remained in complete remission for 5 years, after that presenting with local relapse treated again with the same intensive chemotherapy, resulting in a very good response. Conclusion: the children is alive after a relapsed hepatic angiosarcoma treated with neoadjuvant chemotherapy and partial hepatectomy. In this case, neoadjuvant chemotherapy based in carboplatine, ifofamide and etoposide was an effective strategy to treat pediatric hepatic angiosarcoma.
Synthesis of histidine kinase inhibitors and their biological properties
Authors: Miyanou Rosales‐Hurtado, Patrick Meffre, Hendrik Szurmant, Zohra Benfodda
Journal: Medicinal Research Reviews (2019)

Abstract Infections caused by multidrug‐resistant bacteria represent a significant and ever‐increasing cause of morbidity and mortality. There is thus an urgent need to develop efficient and well‐tolerated antibacterials targeting unique cellular processes. Numerous studies have led to the identification of new biological targets to fight bacterial resistance. Two‐component signal transduction systems are widely employed by bacteria to translate external and cellular signals into a cellular response. They are ubiquitous in bacteria, absent in the animal kingdom and are integrated into various virulence pathways. Several chemical series, including isothiazolidones, imidazolium salts, benzoxazines, salicylanilides, thiophenes, thiazolidiones, benzimidazoles, and other derivatives deduced by different approaches have been reported in the literature to have histidine kinase (HK) inhibitory activity. In this review, we report on the design and the synthesis of these HKs inhibitors and their potential to serve as antibacterial agents.
The association between initial white blood cell count/absolute neutrophil count and mortality in patients with acute coronary syndrome
Authors: Pararayasingam Yogeswaran, Anil Gupta, Rajasree Roy, Ranju Gupta, Nagender Mankan, Sirisha Perumandla, Jasotha Sanmugarajah, Gloria Fernandez, Shafkat Hussain
Journal: Blood (2003)
Transition from chronic stunning to hibernation and further on to necrosis in a porcine model of chronic ischemia identified with PET
Authors: Monika Szilard, Liesbet Mesotten, XS Liu, Johan Nuyts, Alex Maes, YM Huang, Willem Flameng, Eric Verbeken, Luc Mortelmans, Frans Van de Werf, Ivan De Scheerder
Journal: Circulation (2001)
Higher Erythroid Response Rates with Epoetin Alfa Versus Other Agents in Treatment-Naïve Low/Int-1 Myelodysplastic Syndrome Patients: A Comparative Meta-Analysis
Authors: Suneel Mundle, Patrick Lefebvre, Francis Vekeman, Mei Sheng Duh, François Laliberté, Ruchi Rastogi, Victor Moyo
Journal: Blood (2008)
Single Cell RNA Sequencing Identifies Transcriptional Programs That Enhance Anti-Tumor Function of Transgenic CD4+ T Cells Redirected with TCR and CD8αβ
Authors: Jan A Rath, Gagan Bajwa, Benoit Carreres, Isabelle Gruber, Elisabeth Hoyer, Meng-Fen Wu, Yi-Ru Yu, Ping-Chih Ho, Malcolm K. Brenner, David Gfeller, Caroline Arber
Journal: Blood (2019)
Follicular lymphoma: 2020 update on diagnosis and management
Authors: Arnold Freedman, Eric Jacobsen
Journal: American Journal of Hematology (2019)

Follicular lymphoma (FL) is generally an indolent B cell lymphoproliferative disorder of transformed follicular center B cells. Follicular lymphoma is characterized by diffuse lymphadenopathy, bone marrow involvement, and splenomegaly. Extranodal involvement is less common. Cytopenias are relatively common but constitutional symptoms of fever, night sweats, and weight loss are uncommon in the absence of transformation to diffuse large B cell lymphoma.The diagnosis is based on histology from a biopsy of a lymph node or other affected tissue. Incisional biopsy is preferred over needle biopsies in order to give adequate tissue to assign grade and assess for transformation. Immunohistochemical staining is positive in virtually all cases for cell surface CD19, CD20, CD10 and monoclonal immunoglobulin, as well as cytoplasmic expression of bcl-2 protein. The overwhelming majority of cases have the characteristic t(14;18) translocation involving the IgH/bcl-2 genes.The Follicular Lymphoma International Prognostic Index (FLIPI) uses five independent predictors of inferior survival: age > 60 years, hemoglobin <12 g/dL, serum LDH > normal, Ann Arbor stage III/IV, number of involved nodal areas >4. The presence of 0-1, 2, and ≥ 3 adverse factors defines low, intermediate, and high-risk disease. There are other clinical prognostic models but the FLIPI remains the most common. Other factors such as time to relapse of less than 2 years from chemoimmunotherapy and specific gene mutations may also be useful for prognosis. Regardless of the prognostic model used, modern therapies have demonstrably improved prognosis.Observation continues to be appropriate for asymptomatic patients with low bulk disease and no cytopenias. There is no overall survival advantage for early treatment with either chemotherapy or single agent rituximab. For patients needing therapy, most patients are treated with chemoimmunotherapy, which has improved response rates, duration of response and overall survival (OS). Randomized studies have shown additional benefit for maintenance rituximab. Lenalidomide was non-inferior to chemoimmunotherapy in a randomized front-line study and, when combined with rituximab, was superior to rituximab alone in relapsed FL. Kinase inhibitors, other immunotherapies, and stem cell transplantation (SCT) are also considered for recurrent disease.
艾滋病（四）：HIV咨询和艾滋病毒感染者或艾滋病患者的社会心理治疗
Authors: 孔朝霞
Journal: BMJ (2002)

什么是ＨＩＶ咨询 ? 有关艾滋病毒 (ＨＩＶ)和艾滋病 (ＡＩＤＳ)方面的咨询 ,目前已成为整个卫生保健模式的重要组成部分 ,涉及社会心理问题 ,已被纳入对患者的治疗。ＨＩＶ和ＡＩＤＳ咨询主要有两个目标 :(1)预防ＨＩＶ传播 ;(2 )为直接或间接感染ＨＩＶ的患者提供支持。由于改变行为方式可以预防ＨＩＶ的传播 ,因此ＨＩＶ咨询的关键是实现这两个目标。一对一的预防咨询为坦诚讨论患者私人生活中的敏感问题提供特殊的便利 ,在其他场合患者可能会因为担心泄露隐私或遭到指责而拒绝参与讨论。此外 ,当患者得知自己的ＨＩＶ感染状况或病情时 ,可能会因为惧怕排斥、社会歧视、疾病进展和无法确定未来的ＨＩＶ治疗
Design of an antigenic determinant of cefaclor: Chemical structure–IgE recognition relationship
Authors: Angela Martín-Serrano, Cristobalina Mayorga, Esther Barrionuevo, Natalia Pérez, Antonino Romano, Esther Moreno, Adriana Ariza, Ezequiel Pérez-Inestrosa, Maria J. Torres, Maria I. Montañez
Journal: Journal of Allergy and Clinical Immunology (2019)
Coexistence of Trisomy 8 as Both Clonal and Adjunctive Cytogenetic Abnormality in Philadelphia-Positive (Ph+) Chronic Myeloid Leukemia (CML) Patients on Treatment with Tirosine Kinase Inhibitors (TKIs): Report of Two Cases
Authors: Ester Pungolino, Silvia Cantoni, Cecilia Del Curto, Cristina Gabutti, Marianna Caramella, Luciana Barbarano, Michela Draisci, Enrica Morra
Journal: Blood (2008)
Paroxysmal slow cortical activity in Alzheimer’s disease and epilepsy is associated with blood-brain barrier dysfunction
Authors: Dan Z. Milikovsky, Jonathan Ofer, Vladimir V. Senatorov, Aaron R. Friedman, Ofer Prager, Liron Sheintuch, Netta Elazari, Ronel Veksler, Daniel Zelig, Itai Weissberg, Guy Bar-Klein, Evyatar Swissa, Erez Hanael, Gal Ben-Arie, Osnat Schefenbauer, Lyna Kamintsky, Rotem Saar-Ashkenazy, Ilan Shelef, Merav H. Shamir, Ilan Goldberg, Amir Glik, Felix Benninger, Daniela Kaufer, Alon Friedman
Journal: Science Translational Medicine (2019)

A growing body of evidence shows that epileptic activity is frequent but often undiagnosed in patients with Alzheimer's disease (AD) and has major therapeutic implications. Here, we analyzed electroencephalogram (EEG) data from patients with AD and found an EEG signature of transient slowing of the cortical network that we termed paroxysmal slow wave events (PSWEs). The occurrence per minute of the PSWEs was correlated with level of cognitive impairment. Interictal (between seizures) PSWEs were also found in patients with epilepsy, localized to cortical regions displaying blood-brain barrier (BBB) dysfunction, and in three rodent models with BBB pathology: aged mice, young 5x familial AD model, and status epilepticus-induced epilepsy in young rats. To investigate the potential causative role of BBB dysfunction in network modifications underlying PSWEs, we infused the serum protein albumin directly into the cerebral ventricles of naïve young rats. Infusion of albumin, but not artificial cerebrospinal fluid control, resulted in high incidence of PSWEs. Our results identify PSWEs as an EEG manifestation of nonconvulsive seizures in patients with AD and suggest BBB pathology as an underlying mechanism and as a promising therapeutic target.
Improvement of Supportive Care in Patients Undergoing Myeloablative Allogeneic Stem Cell Transplantation Not Only Reduces Transplant-Related Mortality but Also Increases Long-Term Survival
Authors: Benedicte Bruno, David Seguy, Vincent Maunoury, Valerie Coiteux, Leonardo Magro, Francis Bauters, Francoise Mazingue, Jean-Pierre Jouet, Ibrahim Yakoub-Agha
Journal: Blood (2008)
Improving nanotherapy delivery and action through image-guided systems pharmacology
Authors: Thomas S.C. Ng, Michelle A. Garlin, Ralph Weissleder, Miles A. Miller
Journal: Theranostics (2019)

Despite recent advances in the translation of therapeutic nanoparticles (TNPs) into the clinic, the field continues to face challenges in predictably and selectively delivering nanomaterials for the treatment of solid cancers. The concept of enhanced permeability and retention (EPR) has been coined as a convenient but simplistic descriptor of high TNP accumulation in some tumors. However, in practice EPR represents a number of physiological variables rather than a single one (including dysfunctional vasculature, compromised lymphatics and recruited host cells, among other aspects of the tumor microenvironment) - each of which can be highly heterogenous within a given tumor, patient and across patients. Therefore, a clear need exists to dissect the specific biophysical factors underlying the EPR effect, to formulate better TNP designs, and to identify patients with high-EPR tumors who are likely to respond to TNP. The overall pharmacology of TNP is governed by an interconnected set of spatially defined and dynamic processes that benefit from a systems-level quantitative approach, and insights into the physiology have profited from the marriage between in vivo imaging and quantitative systems pharmacology (QSP) methodologies. In this article, we review recent developments pertinent to image-guided systems pharmacology of nanomedicines in oncology. We first discuss recent developments of quantitative imaging technologies that enable analysis of nanomaterial pharmacology at multiple spatiotemporal scales, and then examine reports that have adopted these imaging technologies to guide QSP approaches. In particular, we focus on studies that have integrated multi-scale imaging with computational modeling to derive insights about the EPR effect, as well as studies that have used modeling to guide the manipulation of the EPR effect and other aspects of the tumor microenvironment for improving TNP action. We anticipate that the synergistic combination of imaging with systems-level computational methods for effective clinical translation of TNPs will only grow in relevance as technologies increase in resolution, multiplexing capability, and in the ability to examine heterogeneous behaviors at the single-cell level.
Recurrent Additional Genetic Aberrations and a Novel Mechanism of CBFB-MYH11-Rearrangement in AML M4eo Are Detected Using High-Resolution Genome-Wide Single Nucleotide Polymorphisms (SNPs) Microarrays
Authors: Alexander Kohlmann, Sonja Rauhut, Frank Dicker, Susanne Schnittger, Wolfgang Kern, Torsten Haferlach, Claudia Haferlach
Journal: Blood (2008)
A Phase II Study of Dasatinib in Patients with Chronic Myeloid Leukemia (CML) in Myeloid Blast Crisis Who Are Resistant or Intolerant to Imatinib: First Results of the CA180006 ‘START-B’ Study.
Authors: M. Talpaz, P. Rousselot, D.W. Kim, F. Guilhot, S. Corm, E. Bleickardt, R. Zink, G. Rosti, S. Coutre, C. Sawyers
Journal: Blood (2005)
Allogeneic Stem Cell Transplantation (allo-SCT) from a HLA Identical Sibling for CR1 AML Patients Aged above 55 Years Old after a Reduced Intensity Conditioning: A Survey from the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC).
Authors: Didier Blaise, Zina Chir, Michel Attal, Jean-Henri Bourhis, Jean-Jacques Sotto, Jean-Michel Boiron, Noel Milpied, Jean-Yves Cahn, Bernard Rio, Bruno Lioure, Francois Guilhot, C. Berthou, Agnes Buzyn, Mauricette Michallet
Journal: Blood (2005)
Abstract 196: Comparing Bystander Response to an Unannounced Cardiac Arrest Based on Victim Gender Using an Immersive Virtual Reality System
Authors: Marion Leary, Alfredo Almodovar, David Buckler, Jaldhi Patel, Zainab A Chaudhary, Ariel Karwat, Benjamin S Abella, Audrey L Blewer
Journal: Circulation (2018)

Introduction: Bystander response to a sudden cardiac arrest (SCA) should ideally be the same for all victims, however studies have shown disparities in response exist based on the gender of the victim. Current virtual reality (VR) wearable technology allows for the creation of high realism scenarios permitting manipulation of the victim’s gender in order to observe bystander response. Objectives: We sought to compare lay bystander response to an unannounced simulated VR SCA event based on the victim’s gender. Methods: Using our VR SCA system integrated with a CPR recording manikin, we randomized the avatar victim’s gender to either female or male (Figure 1). Subjects were able to interact with simulated bystanders, give vocal commands such as “call 911” or “get an AED”, and perform CPR on the simulated victim in the virtual environment while simultaneously performing CPR on the manikin. Subjects were unaware of the nature of the event but were told to respond however they would in real-life to an emergency situation. Subject’s ability to proceed through the Chain of Survival (Call 911, Perform CPR, Ask for and Use an AED) and CPR quality were recorded. Results: Between 9/2017 and 12/2017, 75 subjects were enrolled; mean age was 31±11 yrs, 35% were female, 49% were White, and 66% had never been trained in CPR or were trained &gt;2 yrs prior. In total, 59% of subjects performed CPR, and 11% used an AED. CPR was performed on male victims 65% of the time vs 54% on female victims (p=NS, Figure 2a); An AED was used 21% of the time for male victims vs 15% for female victims (p=NS, Figure 2b). If the subject was male, CPR was performed on a female victim 56% of the time vs 71% for a male victim; female subjects performed CPR on a female victim 50% vs 58% on a male victim (p=NS). Conclusion: In our unannounced, immersive VR SCA study, there was a trend toward less CPR and AED use on female avatar victims. Future work will need to be powered to evaluate disparities in CPR and AED use based on gender.
Exposure–Toxicity Association of Cyclophosphamide and Its Metabolites in Infants and Young Children with Primary Brain Tumors: Implications for Dosing
Authors: Olivia Campagne, Bo Zhong, Sreenath Nair, Tong Lin, Jie Huang, Arzu Onar-Thomas, Giles Robinson, Amar Gajjar, Clinton F. Stewart
Journal: Clinical Cancer Research (2019)

To characterize the population pharmacokinetics of cyclophosphamide, active 4-hydroxy-cyclophosphamide (4OH-CTX), and inactive carboxyethylphosphoramide mustard (CEPM), and their associations with hematologic toxicities in infants and young children with brain tumors. To use this information to provide cyclophosphamide dosing recommendations in this population.Patients received four cycles of a 1-hour infusion of 1.5 g/m2 cyclophosphamide. Serial samples were collected to measure cyclophosphamide, 4OH-CTX, and CEPM plasma concentrations. Population pharmacokinetic modeling was performed to identify the patient characteristics influencing drug disposition. Associations between drug exposures and metrics reflecting drug-induced neutropenia, erythropenia, and thrombocytopenia were investigated. A Bayesian approach was developed to predict 4OH-CTX exposure using only cyclophosphamide and CEPM plasma concentrations.Data from 171 patients (0.07-4.9 years) were adequately fitted by a two-compartment (cyclophosphamide) and one-compartment model (metabolites). Young infants (<6 months) exhibited higher mean 4OH-CTX exposure than did young children (138.4 vs. 107.2 μmol/L·h, P < 0.0001). No genotypes exhibited clinically significant influence on drug exposures. Worse toxicity metrics were significantly associated with higher 4OH-CTX exposures. Dosing simulations suggested decreased cyclophosphamide dosage to 1.2 g/m2 for young infants versus 1.5 g/m2 for children to attain similar 4OH-CTX exposure. Bayesian-modeled 4OH-CTX exposure predictions were precise (mean absolute prediction error 14.8% ± 4.2%) and had low bias (mean prediction error 4.9% ± 5.1%).A 4OH-CTX exposure-toxicity association was established, and a decreased cyclophosphamide dosage for young infants was suggested to reduce toxicity in this population. Bayesian modeling to predict 4OH-CTX exposure may reduce clinical processing-related costs and provide insights into further exposure-response associations.
A Hypomorphic Cbfb Allele Reveals Requirements for the Development of T Lymphocytes, Granulocytes, and Monocytes/Macrophages, and for Maintaining Proper Numbers of Hematopoietic Progenitors.
Authors: Laleh Talebian, Zhe Li, Torrey L. Gallagher, Yalin Guo, Caroline L. Speck, Terryl Stacy, Nancy A. Speck
Journal: Blood (2004)
Drug-induced esophagitis
Authors: Joe W. Matthews
Journal: JAMA (1985)

<h3>To the Editor.—</h3> In the Feb 15, 1984, TOPICS IN RADIOLOGY on doxycycline-induced esophagitis<sup>1</sup>there was a table of drugs reported to produce esophagitis. Included among them was the asthma prophylactic agent cromolyn inhalant. It seems unlikely that a drug conjugated to lactose specifically for inhalation into the lung could possibly induce esophagitis when swallowed in small amounts. If the drug is locally irritating or corrosive it could certainly cause at least as much difficulty in the respiratory tract as in the gastrointestinal tract. Allergists have been using cromolyn on a daily basis for a number of years with a very low instance of any side effects. I would appreciate the authors' comment on their source of information for this statement.