tbuckley/cabot-search huggingface dataset:
MULTIPLE NEUROENDOCRINE TUMOR OF THE SMALL BOWEL DIAGNOSED BY CAPSULE ENDOSCOPY
Authors: L Kunovsky, M Dastych, R Kroupa, J Dolina, P Kysela, R Svaton, Z Kala, J Vlazny, J Husty, M Eid, J Trna, K Poredska
Journal: Endoscopy (2019)

Primary malignant tumors of the small bowel constitute only about 1 – 2% of all gastrointestinal neoplasms. Although neuroendocrine tumors (NETs) are relatively rare, they still represent the second most common malignancy of the small bowel (after adenocarcinoma). Clinical manifestations include abdominal pain, bowel obstruction, diarrhea, weight loss and bleeding. The differential diagnosis of obscure gastrointestinal bleeding can sometimes be challenging for endoscopic as well as for radiological methods.
getITD for FLT3-ITD-based MRD monitoring in AML
Authors: Tamara J. Blätte, Laura K. Schmalbrock, Sabrina Skambraks, Susanne Lux, Sibylle Cocciardi, Anna Dolnik, Hartmut Döhner, Konstanze Döhner, Lars Bullinger
Journal: Leukemia (2019)

1 Subjects & Methods SamplesFor assay assessment, we sequenced AML cell lines (n = 3), samples from healthy volunteers (n = 2, from peripheral blood (PB)) and AML patient samples (n = 57 samples, from bone marrow aspirates (BM)).In total, and including all technical replicates, we sequenced and analyzed 90 samples.The human AML cell lines HL-60 (FLT3 -ITD negative control 1 ), MOLM-14 (FLT3 -ITD positive control, 21 bp ITD 1 ) and PL-21 (FLT3 -ITD positive control, 126 bp ITD 1 ) were obtained from the German cell line repository DSMZ (Leibniz Institute DSMZ -German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany).The 57 AML samples were derived from 28 AML patients who were all included in the AMLSG BiO Registry study (ClinicalTrials.govidentifier: NCT01252485) and gave their informed consent for both biobanking and genomic analysis of leukemia samples according to the Declaration of Helsinki.For initial assay assessment, we sequenced 3 FLT3 -ITD negative controls (healthy volunteers, n = 2; AML cell line HL-60), 2 FLT3 -ITD positive controls (AML cell lines MOLM-14 and PL-21) and diagnosis samples of 28 AML patients who previously tested FLT3 -ITD positive by PCR-and capillary electrophoresis-based fragment analysis (FA).To further evaluate our assay in the context of MRD monitoring of FLT3 -ITD positive AML, we sequenced 29 follow-up samples of 10 of these AML patients, five of whom achieved continuous complete remission and five of whom relapsed from the disease.For all patients, at least one sample from complete remission, following induction therapy, and at least one additional follow-up sample, either from continued complete remission or the time of relapse,
DOES THIRD-SPACE ENDOSCOPY PROVIDE PROMISING RESULTS FOR THE REMOVAL OF UPPER GASTROINTESTINAL SUBMUCOSAL TUMORS?
Authors: F Aslan, E Kocak, B Sengun, S Nafiz Karahan, O Yilmaz, O Cig Taskin, O Agcaoglu
Journal: Endoscopy (2019)

Submucosal-tunneling endoscopic resection (STER) has been a promising technique for treating upper-gastrointestinal submucosal tumors (SMT) originating from the muscularis propria layer. In this study, we aim to present perioperative outcomes of 31 patients with SMTs who underwent STER procedure in a tertiary care center.
Residual Inflammatory Risk in Patients With Low LDL Cholesterol Levels Undergoing Percutaneous Coronary Intervention
Authors: Paul Guedeney, Bimmer E. Claessen, Deborah N. Kalkman, Melissa Aquino, Sabato Sorrentino, Gennaro Giustino, Serdar Farhan, Birgit Vogel, Samantha Sartori, Gilles Montalescot, Joseph Sweeny, Jason C. Kovacic, Prakash Krishnan, Nitin Barman, George Dangas, Annapoorna Kini, Usman Baber, Samin Sharma, Roxana Mehran
Journal: Journal of the American College of Cardiology (2019)
Validating the CTS5 algorithm with the IDEAL study cohort
Authors: I. Noordhoek, E. Blok, E. Meershoek-Klein Kranenbarg, H. Putter, M. Duijm-De Carpentier, C. van de Velde, G.-J. Liefers, J.R. Kroep, J.E.A. Portielje
Journal: Annals of Oncology (2019)

Background: Half of the distant recurrences (DR) occur after the first five years from diagnosis. The Clinical Treatment Score post-5 years (CTS5) intends to predict DR after 5 years of endocrine therapy (ET). This study uses the IDEAL study cohort, consisting of patients disease free after 5 years of standard adjuvant ET and randomized between 2.5 or 5 years of extended therapy with letrozole, to validate the CTS5 as a prognostic tool for late DR and, if it is validated, to examine it as a predictive tool for choosing between 2.5 years or 5 years of extended ET. Methods: The CTS5 categorizes patients that had been disease free for 5 years, into low (<5%), intermediate (5-10%) and high (>10%) risk groups for developing DR between 5 and 10 years after diagnosis. To validate the CTS5, both the discrimination and calibration are examined. Results: In this analysis, 1591 patients from the IDEAL study cohort were included. Overall, they were younger, had more lymph node involvement, higher grade tumours and received more chemotherapy than patients in the ATAC and 1BIG 1-98 cohorts used to train and test the CTS5. Consequently, more patients were allocated to the high risk group than in the training and testing cohort. For the prognostic value of the CTS5 score, we showed that there were significantly more DR between 5 and 10 years after diagnosis in the high risk group (HR 4.9, 95% CI 2.3-10.1) and the intermediate risk group (HR 2.2, 95% CI 1.03-4.8) compared to the low risk group (log-rank p < 0.001). The expected risk scores for the low, intermediate and high risk groups, calculated using the CTS5 scores, were 3.6%, 7.2% and 19.4%, respectively. The observed late DR using K-M curves were 1.4% (95% CI 0.7-2.1), 5.6% (4.7-6.5) and 10.6% (9.4-11.8) for the low, intermediate and high risk groups, respectively. The CTS5 risk score systematically overestimates the risk of late DR. Since the algorithm could not be validated, it was not deemed relevant to examine its predictive abilities for extended ET within the risk groups. Conclusions: The CTS5 is able to significantly discriminate patients into three different risk categories. However, the calibration could not be validated, as the absolute risk for DR was significantly lower than the expected DR. The CTS5 should therefore not be used as prognostic tool for distant breast cancer recurrences. Clinical trial identification: BOOG 2006-05. Legal entity responsible for the study: CJH van de Velde. Funding: The original IDEAL trial was supported by Novartis by means of an independent educational grant (CFEM345DNL03). This IDEAL substudy received no additional funding. Disclosure: All authors have declared no conflicts of interest.
MOLECULAR ENDOSCOPIC IMAGING FOR DETECTION OF BARRETT'S ESOPHAGUS (BE) USING NANOPARTICLES
Authors: S Ahmed, E Hoque Chowdhury, PR Galle, H Neumann
Journal: Endoscopy (2019)

Early detection of BE may allow for more effective surveillance. Molecular endoscopic imaging (MEI) permits visualization of disease-specific molecular alterations. Past studies on MEI have used antibodies for detection of disease-specific targets. In contrast, nanoparticles can be coated with stronger fluorophores and can also be loaded with ligands to multiple biomarkers. To date, no data is available on the use of nanoparticles for MEI.
Abstract 18767: Race-related Disparities in Ventricular-arterial Coupling in Elderly Individuals: The Atherosclerosis Risk in Communities Study
Authors: Miguel M Fernandes-Silva, Amil M Shah, Sheila M Hegde, Alexandra Goncalves, Brian Claggett, Susan Cheng, Wilson Nadruz, Carolyn S Lam, Barry A Borlaug, Scott D Solomon
Journal: Circulation (2015)

Introduction: The incidence of heart failure (HF) is higher in black than in white Americans, but the causes are unclear. We proposed that ethnic differences in ventricular-arterial interaction may contribute to this differential HF risk. Methods: We studied measures of arterial elastance (Ea) and left ventricle (LV) end-systolic elastance (Ees) in 5767 community-based elderly participants (76±5 years, 41% male, 22% black) who underwent echocardiography in the Atherosclerosis Risk in Community (ARIC) Study. Results: Black participants were more frequently women (66 vs 57%) and had a higher prevalence of obesity (46 vs 31%), hypertension (94 vs 80%), and diabetes mellitus (47 vs 34%). Adjusting for these baseline differences, the prevalence of LV hypertrophy was similar, but Ea, Ees and Ea/Ees ratio were higher in blacks than whites, particularly in black women (Figure). Ea was positively associated with LV mass index and E/e’ ratio in blacks, but not in whites (p for interaction &lt; 0.001). Conclusion: These community-based data demonstrate that ventricular-arterial stiffening is greater in black than white Americans, coupled with more ventricular remodeling and dysfunction. The heightened afterload dependence in blacks suggests greater potential for risk reduction with anti-hypertensive therapy.
CONFOCAL LASER ENDOMICROSCOPY IN THE ASSESSMENT OF PERSISTENT OR RECURRENT INTESTINAL METAPLASIA/NEOPLASIA AFTER ENDOSCOPIC TREATMENT OF BARRETT'S ESOPHAGUS RELATED NEOPLASIA – A PROSPECTIVE STUDY
Authors: J Krajciova, M Kollar, J Maluskova, M Kment, Z Vackova, J Spicak, J Martinek
Journal: Endoscopy (2019)

Patients after endoscopic treatment of Barrett's esophagus related neoplasia (BORN) should undergo regular endoscopic surveillance. Probe-based confocal laser endomicroscopy (pCLE) offers detailed examination of cellular structures and may examine larger areas compared to standard biopsy. The aim of this study was to evaluate the efficacy of pCLE (vs. standard biopsies) in detection of persistent/recurrent intestinal metaplasia (IM)/neoplasia (N) in patients after endoscopic treatment of BORN.
N-Glycosylation Defects in Humans Lower Low-Density Lipoprotein Cholesterol Through Increased Low-Density Lipoprotein Receptor Expression
Authors: Marjolein A.W. van den Boogert, Lars E. Larsen, Lubna Ali, Sacha D. Kuil, Patrick L.W. Chong, Anke Loregger, Jeffrey Kroon, Johan G. Schnitzler, Alinda W.M. Schimmel, Jorge Peter, Johannes H.M. Levels, Gerry Steenbergen, Eva Morava, Geesje M. Dallinga-Thie, Ron A. Wevers, Jan Albert Kuivenhoven, Nicholas J. Hand, Noam Zelcer, Daniel J. Rader, Erik S.G. Stroes, Dirk J. Lefeber, Adriaan G. Holleboom
Journal: Circulation (2019)

The importance of protein glycosylation in regulating lipid metabolism is becoming increasingly apparent. We set out to further investigate this by studying patients with type I congenital disorders of glycosylation (CDGs) with defective N-glycosylation.We studied 29 patients with the 2 most prevalent types of type I CDG, ALG6 (asparagine-linked glycosylation protein 6)-deficiency CDG and PMM2 (phosphomannomutase 2)-deficiency CDG, and 23 first- and second-degree relatives with a heterozygous mutation and measured plasma cholesterol levels. Low-density lipoprotein (LDL) metabolism was studied in 3 cell models-gene silencing in HepG2 cells, patient fibroblasts, and patient hepatocyte-like cells derived from induced pluripotent stem cells-by measuring apolipoprotein B production and secretion, LDL receptor expression and membrane abundance, and LDL particle uptake. Furthermore, SREBP2 (sterol regulatory element-binding protein 2) protein expression and activation and endoplasmic reticulum stress markers were studied.We report hypobetalipoproteinemia (LDL cholesterol [LDL-C] and apolipoprotein B below the fifth percentile) in a large cohort of patients with type I CDG (mean age, 9 years), together with reduced LDL-C and apolipoprotein B in clinically unaffected heterozygous relatives (mean age, 46 years), compared with 2 separate sets of age- and sex-matched control subjects. ALG6 and PMM2 deficiency led to markedly increased LDL uptake as a result of increased cell surface LDL receptor abundance. Mechanistically, this outcome was driven by increased SREBP2 protein expression accompanied by amplified target gene expression, resulting in higher LDL receptor protein levels. Endoplasmic reticulum stress was not found to be a major mediator.Our study establishes N-glycosylation as an important regulator of LDL metabolism. Given that LDL-C was also reduced in a group of clinically unaffected heterozygotes, we propose that increasing LDL receptor-mediated cholesterol clearance by targeting N-glycosylation in the LDL pathway may represent a novel therapeutic strategy to reduce LDL-C and cardiovascular disease.
HIGH ACCURANCY OF TRANSDUODENAL ENDOSCOPIC FINE NEEDLE BIOPSY USING A 19 G FLEXIBLE NEEDLE: A RETROSPECTIVE MULTICENTER STUDY
Authors: G de Nucci, MC Petrone, N Imperatore, E Forti, R Grassia, S Giovanelli, L Ottaviani, V Mirante, M Manno, C Fabbri, PG Arcidiacono, G Manes
Journal: Endoscopy (2019)

Endoscopic ultrasound-guided fine needle aspiration (EUS FNA) is the gold standard to obtain samples from gastrointestinal tract and pancreatic lesions. EUS-FNA is accurate especially when rapid on-site evaluation (ROSE) is performed. The use of EUS-guided fine needle biopsy (EUS FNB) can give a chance to reach a diagnosis. For lesions from the duodenum, it' s recommended the use of a nitinol 19-gauge needle that is more flexible. Recent data shared doubts about feasibility and safety of this needles used through the duodenum. The aim of the study is to evaluate the feasibility, safety and accuracy of 19-gauge nitinol flexible needle in patients with solid lesions punctured from duodenum.
Multifocal Meningiomas Mimicking Dural-Based Intracranial Metastases at 18F-Fluciclovine PET/CT
Authors: Mark S. Manganaro, John D. Millet, Matthew S. Manganaro
Journal: Clinical Nuclear Medicine (2019)

Abstract A 78-year-old man with biochemically recurrent prostate adenocarcinoma (prostate-specific antigen, 2.3 ng/mL) but without detectable disease in the chest, abdomen, or pelvis at conventional CT imaging or in the bones at 99m Tc-MDP scintigraphy underwent 18 F-fluciclovine (anti–1-amino-3- 18 F-fluorocyclobutane-1-carboxylic acid) PET/CT to evaluate for occult recurrent or metastatic disease. Imaging identified intense radiotracer uptake within 3 dural-based lesions along the left cerebral convexity. Subsequent MRI and biopsy confirmed multifocal World Health Organization grade 2 atypical meningiomas. Focal intracranial radiotracer uptake at 18 F-fluciclovine PET/CT may create a diagnostic dilemma as incidental meningiomas can mimic intracranial metastases.
THE NEW INTERNATIONAL BLEEDING RISK SCORE SYSTEM IS A USEFUL PREDICTOR OF MORTALITY IN PATIENTS WITH NON-VARICEAL UPPER GASTROINTESTINAL BLEEDING
Authors: HS Moon, MS Kim, JH Park, JS Kim, SH Kang, JK Sung, HY Jeong
Journal: Endoscopy (2019)

To validate the use of the new international bleeding score for prediction of mortality in patients with non-variceal upper gastrointestinal bleeding and to assess whether a high new score can predict re-bleeding or an extended hospital stay.
Adjuvant trastuzumab in stage I breast cancer with the tumour size &lt; 1 cm: Our centre experience
Authors: H. Belikova, A. Alhasso
Journal: Annals of Oncology (2019)

Background: Small node-negative breast cancers measuring less than 1 cm are generally associated with a favorable prognosis. Around 10% of these malignances exhibit human epidermal growth factor receptor 2 (HER2) overexpression and/or amplification. Patients with HER2+ tumors have a higher risk of recurrence. Several large retrospective reviews have reported a lower overall survival among HER2+ cases in the pT1a/b N0 patient group where adjuvant treatment was not given. In this retrospective study we looked at our institutional experience of using trastuzumab (Herceptin®) in early breast cancer, and how the outcomes compared to the same stage of HER2+ group not treated with Herceptin®, or HER2- group. Methods: A retrospective review of 963 early breast cancer cases staged pT1a and pT1b N0 who underwent surgical treatment in 2009-2015.The data was collected using clinical electronic resources including Clinical Portal, TrakCare, ChemoCare and PACS. Statistical analysis comparing HER2+ and HER2- groups using an individualised pairwise matching was performed. Results: In total, 1045 cases of breast cancer treated in the Beatson Cancer Centre between 2009 and 2015 were analyzed. 82 patients were excluded from the analysis due to an upstaging. We had 4.4% of pT1/pT2 N0 breast cancers which were HER2 + (42 cases). We have matched HER2+ group with 42 cases from the HER2- group using age, tumor size, grade, hormonal status, adjuvant treatment and type of surgery, to allow a direct comparison. The recurrence rate was 2.3% in HER2- group compared to 6.8% in HER2+ group when Herceptin® was not given. From our small sample size of 42 HER2+ cases, 31% have received adjuvant Herceptin® and none of those patients had a recurrent disease with an average follow up of 5 years. Conclusions: The risk of recurrent breast cancer after completion of standard radical treatment appears to be higher in HER2+ve cases even in early stage disease with tumor size less than 1 cm. In HER2+ve breast cancer staged pT1a/pT1b N0, adjuvant treatment with Herceptin® may reduce the risk of recurrence. The sample size is too small to draw any statistically significant conclusions but our data come in tune with the findings from the other trials. Legal entity responsible for the study: Abdulla Alhasso. Funding: Has not received any funding. Disclosure: All authors have declared no conflicts of interest.
Anterior Leaflet Laceration to Prevent Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Replacement
Authors: Jaffar M. Khan, Vasilis C. Babaliaros, Adam B. Greenbaum, Jason R. Foerst, Shahram Yazdani, James M. McCabe, Gaetano Paone, Marvin H. Eng, Bradley G. Leshnower, Patrick T. Gleason, Marcus Y. Chen, Dee Dee Wang, Xin Tian, Annette M. Stine, Toby Rogers, Robert J. Lederman
Journal: Journal of the American College of Cardiology (2019)
POLYP FINGERPRINT: AUTOMATIC RECOGNITION OF UNIQUE FEATURES TO UNIVOCALLY IDENTIFY COLORECTAL POLYPS
Authors: A García-Rodríguez, J Bernal, H Córdova, C Rodríguez de Miguel, R Garcés, M Pellisé, J Sánchez, G Fernández-Esparrach
Journal: Endoscopy (2019)

Following human recognition by fingerprints, we propose to study the potential of computer systems in the definition and recognition of unique characteristics for each colorectal polyp. Polyp fingerprint can be used in two types of applications: assistance in polyp detection to ensure that a polyp observed during insertion is recognized during withdrawal and assistance in the in-vivo prediction of the histology of those polyps sharing a similar appearance with one with known histology.
Reply to Thomas Gevaert, Markus Eckstein, Rodolfo Montironi, and Antonio Lopez-Beltran's Letter to the Editor re: Maud Rijnders, Astrid A.M. van der Veldt, Tahlita C.M. Zuiverloon, et al. PD-L1 Antibody Comparison in Urothelial Carcinoma. Eur Urol 2019;75:538–40
Authors: Maud Rijnders, Astrid A.M. van der Veldt, Ronald de Wit, Geert J.L.H. van Leenders
Journal: European Urology (2019)
Monitoring a Combination of Calprotectin and Infliximab Identifies Patients With Mucosal Healing of Crohn’s Disease
Authors: Erwin Dreesen, Filip Baert, David Laharie, Peter Bossuyt, Yoram Bouhnik, Anthony Buisson, Guy Lambrecht, Edouard Louis, Bas Oldenburg, Benjamin Pariente, Marieke Pierik, C. Janneke van der Woude, Geert D’Haens, Séverine Vermeire, Ann Gils
Journal: Clinical Gastroenterology and Hepatology (2019)
Clinical Application of Volatile Organic Compound–Based Exhaled Breath Tests for Cancer Diagnosis
Authors: Yubin Cao, Chunjie Li, Longjiang Li
Journal: JAMA Oncology (2019)

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Abstract MP11: Acculturation is Associated with a Higher Prevalence of Cardiometabolic Risk Factors in US Immigrants: An Analysis of the 2010-2014 National Health Interview Survey
Authors: Nwakaego Ukonu, Olawunmi Obisesan, Jonathan Aboagye, Kojo Amoakwa, Charles Agyemang, Yvonne Y Commodore-Mensah
Journal: Circulation (2016)

Background: The burden of cardiometabolic disease and associated risk factors including overweight/obesity, diabetes and hypertension is high in ethnic minorities in the United States (US). The size of the immigrant population in the US continues to grow rapidly. It has been posited that acculturation to the US society results in an elevation or reduction of risk for cardiometabolic disease in immigrants. Hypothesis: We hypothesized that increased years of US residence (proxy measure for acculturation) would be associated with a higher prevalence of overweight/obesity, diabetes and hypertension, known risk factors for cardiometabolic disease, in US immigrants. Methods: We analyzed data on adult US immigrants in the National Health Interview Survey (NHIS) from 2010-2014. The immigrants were from the following 9 regions of birth: Europe, South America, Mexico/Central America/Caribbean, Russia, Africa, Middle East, India, Central and Southeast Asia. The main independent variable was length of US residence; &lt;10 years and ≥10 years. The main outcome variables were hypertension, overweight/obesity and diabetes. We used multivariable logistic regression to examine these associations and adjusted for known confounders. Results: Of the 54,984 immigrants, 62% were overweight/obese, 20 % had hypertension and 8% had diabetes. The mean age (± SE) was 43 (±0.15) years. Half were females and those who had resided in the US for ≥10 years were more likely to have health insurance coverage (70% vs 54%, p&lt;0.001) and older (46 years vs 35years, p&lt;0.001) compared to immigrants with &lt;10 years of duration of stay. After adjusting for region of birth, poverty income ratio, age and sex, we observed that immigrants residing in the US for ≥10 years were more likely to be overweight/obese (Odds Ratio[OR] 1.21, 95% CI 1.11-1.31), diabetic (OR: 1.58, 95% CI 1.32-1.90) and hypertensive(OR: 1.34, 95% CI 1.19-1.50) than those residing in the US for &lt;10 years. Conclusion: In an ethnically diverse sample of contemporary US immigrants, we found that increased length of US residence (acculturation) was associated with overall presence of cardiometabolic risk factors. Culturally-tailored public health strategies should be developed and implemented in immigrant sub-populations in the US to prevent the development of cardiometabolic disease.
OPTIMAL TIMING OF ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY IN ELDERLY PATIENTS WITH ACUTE CHOLANGITIS
Authors: B Miutescu, I Ratiu, A Popescu, R Sirli, M Danila, E Hajdarmataj, F Bende, I Sporea
Journal: Endoscopy (2019)

Acute cholangitis may deteriorate the patients condition due to sepsis, therefore antibiotic therapy and biliary decompression is mandatory. Endoscopic retrograde cholangiopancreatography (ERCP) is the first line procedure used for biliary drainage. Our aim was to define the clinical impact of ERCP timing in elderly patients with acute cholangitis.