tbuckley/cabot-search huggingface dataset:
Comparative effectiveness of physical exercise interventions for chronic non-specific neck pain: a systematic review with network meta-analysis of 40 randomised controlled trials
Authors: Rutger MJ de Zoete, Nigel R Armfield, James H McAuley, Kenneth Chen, Michele Sterling
Journal: British Journal of Sports Medicine (2020)

Objective To compare the effectiveness of different physical exercise interventions for chronic non-specific neck pain. Design Systematic review and network meta-analysis. Data sources Electronic databases: AMED, CINAHL, Cochrane Central Register of Controlled Trials, Embase, MEDLINE, Physiotherapy Evidence Database, PsycINFO, Scopus and SPORTDiscus. Eligibility criteria Randomised controlled trials (RCTs) describing the effects of any physical exercise intervention in adults with chronic non-specific neck pain. Results The search returned 6549 records, 40 studies were included. Two networks of pairwise comparisons were constructed, one for pain intensity (n=38 RCTs, n=3151 participants) and one for disability (n=29 RCTs, n=2336 participants), and direct and indirect evidence was obtained. Compared with no treatment, three exercise interventions were found to be effective for pain and disability: motor control (Hedges’ g , pain −1.32, 95% CI: −1.99 to −0.65; disability −0.87, 95% CI: –1.45 o −0.29), yoga/Pilates/Tai Chi/Qigong (pain −1.25, 95% CI: –1.85 to −0.65; disability –1.16, 95% CI: –1.75 to −0.57) and strengthening (pain –1.21, 95% CI: –1.63 to −0.78; disability –0.75, 95% CI: –1.28 to −0.22). Other interventions, including range of motion (pain −0.98 CI: −2.51 to 0.56), balance (pain −0.38, 95% CI: −2.10 to 1.33) and multimodal (three or more exercises types combined) (pain −0.08, 95% CI: −1.70 to 1.53) exercises showed uncertain or negligible effects. The quality of evidence was very low according to the GRADE (Grading of Recommendations Assessment, Development and Evaluation) criteria. Conclusion There is not one superior type of physical exercise for people with chronic non-specific neck pain. Rather, there is very low quality evidence that motor control, yoga/Pilates/Tai Chi/Qigong and strengthening exercises are equally effective. These findings may assist clinicians to select exercises for people with chronic non-specific neck pain. PROSPERO registration number CRD42019126523.
Challenges in the Treatment of Newly Diagnosed and Recurrent Primary Central Nervous System Lymphoma
Authors: Matthias Holdhoff, Maciej M. Mrugala, Christian Grommes, Thomas J. Kaley, Lode J. Swinnen, Carlos Perez-Heydrich, Lakshmi Nayak
Journal: Journal of the National Comprehensive Cancer Network (2020)

Primary central nervous system lymphomas (PCNSLs) are rare cancers of the central nervous system (CNS) and are predominantly diffuse large B-cell lymphomas of the activated B-cell (ABC) subtype. They typically present in the sixth and seventh decade of life, with the highest incidence among patients aged &gt;75 years. Although many different regimens have demonstrated efficacy in newly diagnosed and relapsed or refractory PCNSL, there have been few randomized prospective trials, and most recommendations and treatment decisions are based on single-arm phase II trials or even retrospective studies. High-dose methotrexate (HD-MTX; 3–8 g/m 2 ) is the backbone of preferred standard induction regimens. Various effective regimens with different toxicity profiles can be considered that combine other chemotherapies and/or rituximab with HD-MTX, but there is currently no consensus for a single preferred regimen. There is controversy about the role of various consolidation therapies for patients who respond to HD-MTX–based induction therapy. For patients with relapsed or refractory PCNSL who previously experienced response to HD-MTX, repeat treatment with HD-MTX–based therapy can be considered depending on the timing of recurrence. Other more novel and less toxic regimens have been developed that show efficacy in recurrent disease, including ibrutinib, or lenalidomide ± rituximab. There is uniform agreement to delay or avoid whole-brain radiation therapy due to concerns for significant neurotoxicity if a reasonable systemic treatment option exists. This article aims to provide a clinically practical approach to PCNSL, including special considerations for older patients and those with impaired renal function. The benefits and risks of HD-MTX or high-dose chemotherapy with autologous stem cell transplantation versus other, better tolerated strategies are also discussed. In all settings, the preferred treatment is always enrollment in a clinical trial if one is available.
Abstract 342: Cortical Bone Stem Cell Therapy Alters Macrophage Phenotype and Reduces Cardiac Cell Death After Myocardial Infarction
Authors: Alexander R Hoachlandr-Hobby, Remus M Berretta, Yijun Yang, Eric Feldsott, Hajime Kubo, Sadia Mohsin, Steven R Houser
Journal: Circulation Research (2020)

Acute injuries to the heart, like myocardial infarction (MI), contribute to the development and pathology of heart failure (HF). Reperfusion of the ischemic heart greatly increases survival but results in reperfusion injury that can account for up to 50% of the final infarct size. The inflammatory response to MI-induced myocardial injury is thought to be responsible for the propagation of reperfusion injury into the infarct border zone, expanding myocardial damage. We have previously shown in a swine model of MI that intramyocardial injections of cortical bone-derived stem cells (CBSCs) into the infarct border zone has no acute cardioprotective effect but reduces scar size by half and prevents the decline of ejection fraction and LV dilation 3 months after MI. Our new preliminary data show that CBSCs have potent immunoregulatory capabilities. Therefore, we hypothesize that CBSC treatment has an effect on the immune response to MI that improves the wound healing response to myocardial injury and mitigates LV remodeling and infarct size 3 months later. To test this hypothesis, we characterized the effects of CBSC paracrine factors on macrophages in vitro and found that CBSC-treated macrophages express higher levels of CD206, produce more IL-1RA and IL-10, and phagocytose apoptotic myocytes more efficiently. In addition, macrophages were increased in CBSC-treated swine hearts 7 days after MI compared to controls with a corresponding increase in IL-1RA and TIMP-2. Apoptosis was decreased overall and in macrophages specifically in CBSC-treated animals. From these data we conclude CBSCs may exert an acute pro-reparative effect on the immune response after MI, reducing reperfusion injury and adverse remodeling resulting in improved functional outcomes at later time points.
Outcomes of Non-Myeloablative HLA-Haploidentical Bone Marrow Transplant with Thiotepa and Post-Transplant Cyclophosphamide in Children and Adults with Severe Sickle Cell Disease, a Phase II Trial: Vanderbilt Global Haploidentical Transplant Learning Collaborative (VGC2)
Authors: Adetola A. Kassim, Josu de la Fuente, Ali Debsan Alahmari, Michael J. Eckrich, Rabi Hanna, Nathalie Dhedin, Biljana N. Horn, Vandy Black, Roseane V Gouveia, Adriana Seber, Belinda Pinto Simões, Thalita Cristina de Mello Costa, Renato Guerino-Cunha, Carmem M. S. Bonfim, Roberto Luiz da Silva, Nelson Hamerschlak, Juliana Folloni Fernandes, Michael Kent, Satya Prakash Yadav, Erfan Nur, Mohsen Alzahrani, Ben Carpenter, William Tse, Maria Isabel, Hemalatha G Rangarajan, Ibrahim Ahmed, Adeseye Michael Akinsete, Courtney D. Fitzhugh, Kathryn A. Culos, Leena Karnik, James Connelly, Carrie Kitko, Jennifer Andrews, Karina L Wilkerson, Robert Brodsky, Tatsuki Koyama, Michael R. DeBaun
Journal: Blood (2020)
Maximal Tolerated Dose of the BCL-2 Inhibitor Venetoclax in Combination with Daunorubicin/Cytarabine Induction in Previously Untreated Adults with Acute Myeloid Leukemia (AML)
Authors: Richard M. Stone, Daniel J. DeAngelo, Anthony G. Letai, Jeremy M. Stewart, Michael McGinnis, Francis Brown, Geoffrey Fell, Yael Flammand, Marina Konopleva, Jacqueline S. Garcia, Marlise R Luskin
Journal: Blood (2020)
Abstract 335: Distinct Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid Linked Phospholipids on Membrane Structure
Authors: Preston Mason, Samuel Sherratt, Deepak L Bhatt
Journal: Circulation Research (2020)

In REDUCE-IT, prescription eicosapentaenoic acid (EPA), an omega-3 fatty acid (O3FA), significantly reduced ischemic events in patients with diabetes or cardiovascular disease. Treatments containing docosahexaenoic acid (DHA) have not shown similar benefits in other trials. EPA and DHA differentially influence lipid oxidation, signal transduction, fluidity, and cholesterol domain formation, potentially due to distinct membrane interactions. Small angle x-ray diffraction approaches compared the separate and combined effects of 1-palmitoyl-2-eicosapentaenoyl-sn-glycero-3-phosphocholine (PL-EPA) and 1-palmitoyl-2-docosahexaenoic-sn-glycero-3-phosphocholine (PL-DHA) at a 1:20 ratio in membranes composed of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (PL-OA) and cholesterol (C) at a 0.3:1 C:PL ratio. As a control, we also evaluated membranes consisting of PL-OA and C only. Electron density profiles (electrons/Å 3 vs Å) generated from the diffraction data served to determine membrane structure, including its width or d -space, at 1 Å resolution (Fig. 1A). Addition of PL-EPA increased membrane hydrocarbon core electron density over a broad area ± 0-10 Å from the membrane center, indicating an energetically favorable extended membrane orientation for EPA, stabilized by van der Waals interactions (Fig. 1B). By contrast, PL-DHA increased electron density in the phospholipid head group region concomitant with disordering in the hydrocarbon core ± 0-9 Å (Fig. 1C). Addition of the PL-O3FAs did not alter the overall membrane width (57 ± 1 Å). The combination of PL-EPA with PL-DHA highly attenuated their separate effects on the hydrocarbon core and headgroup (Fig. 1D). The contrasting EPA and DHA effects on membrane structure signify distinct molecular orientations that may contribute to observed differences in biological activity.
The Combinatorial Activity of Eftozanermin (ABBV-621), a Novel and Potent TRAIL Receptor Agonist Fusion Protein, in Pre-Clinical Models of Hematologic Malignancies
Authors: Morey L Smith, Sha Jin, Dong Chen, Haichao Zhang, Jason Huska, Deborah Widomski, Vicky Bontcheva, Greg Buchanan, Susan Morgan-Lappe, Darren C. Phillips, Stephen K Tahir
Journal: Blood (2020)
Hexosamine biosynthetic pathway promotes the antiviral activity of SAMHD1 by enhancing O-GlcNAc transferase-mediated protein O-GlcNAcylation
Authors: Jie Hu, Qingzhu Gao, Yang Yang, Jie Xia, Wanjun Zhang, Yao Chen, Zhi Zhou, Lei Chang, Yuan Hu, Hui Zhou, Li Liang, Xiaosong Li, Quanxin Long, Kai Wang, Ailong Huang, Ni Tang
Journal: Theranostics (2020)

Rationale:Viruses hijack the host cell machinery to promote viral replication; however, the mechanism by which metabolic reprogramming regulates innate antiviral immunity in the host remains elusive.Herein, we explore how the hexosamine biosynthesis pathway (HBP) and O-linked-N-acetylglucosaminylation (O-GlcNAcylation) regulate host antiviral response against hepatitis B virus (HBV) in vitro and in vivo.Methods: We conducted a metabolomics assay to evaluate metabolic responses of host cells to HBV infection.We systematically explored the role of HBP and protein O-GlcNAcylation in regulating HBV infection in cell and mouse models.O-linked N-acetylglucosamine (O-GlcNAc) target proteins were identified via liquid chromatography-tandem mass spectrometry (LC-MS) and co-immunoprecipitation assays.Additionally, we also examined uridine diphosphate (UDP)-GlcNAc biosynthesis and O-GlcNAcylation levels in patients with chronic hepatitis B (CHB).Results: HBV infection upregulated GLUT1 expression on the hepatocyte surface and facilitated glucose uptake, which provides substrates to HBP to synthesize UDP-GlcNAc, leading to an increase in protein O-GlcNAcylation.Pharmacological or transcriptional inhibition of HBP and O-GlcNAcylation promoted HBV replication.Mechanistically, O-GlcNAc transferase (OGT)-mediated O-GlcNAcylation of sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1) on Ser93 stabilizes SAMHD1 and enhances its antiviral activity.Analysis of clinical samples revealed that UDP-GlcNAc level was increased, and SAMHD1 was O-GlcNAcylated in patients with CHB.Conclusions: HBP-mediated O-GlcNAcylation positively regulates host antiviral response against HBV in vitro and in vivo.The findings reveal a link between HBP, O-GlcNAc modification, and innate antiviral immunity by targeting SAMHD1.
The Comparison of Frontline Lower-Dose Dasatinib 50 Mg/Day to Standard-Dose Dasatinib 100 Mg/Day in Newly Diagnosed Chronic Myeloid Leukemia: A Propensity Score Analysis
Authors: Koji Sasaki, Elias Jabbour, Kiran Naqvi, Jeffrey Skinner, Kristin Anderson, Sara E Dellasala, Musa Yilmaz, Alessandra Ferrajoli, Prithviraj Bose, Philip A. Thompson, Yesid Alvarado, Nitin Jain, Guillermo Garcia-Manero, Koichi Takahashi, Jan A. Burger, Gautam Borthakur, Naveen Pemmaraju, Rita Khouri, Shilpa Paul, Sherry A. Pierce, Jorge E. Cortes, Hagop M. Kantarjian
Journal: Blood (2020)
A Novel View of the Role of Prostaglandin E2 (PGE2) in Facilitating Engraftment of HSPCs By Activating the NOX2-ROS-Nlrp3 Inflammasome Axis to Incorporate the CXCR4 Receptor into Membrane Lipid Rafts
Authors: Magdalena Kucia, Kamila Bujko, Arjun Thapa, Janina Ratajczak, Mariusz Z Ratajczak
Journal: Blood (2020)
Sars Cov-2/COVID-19 in Multiple Myeloma Latin-American Patients <i>COVID-Lamm Study on Behalf of Gelamm (</i> <i>Grupo de Estudio Latino- Americano de Mieloma Múltiple</i> <i>)</i>
Authors: Humberto Martínez Cordero, Camila Peña, Dorotea Fantl, Eloisa Riva, Natalia Paola Schutz, Virginia Abello, Guillermo Ruiz Arguelles, Aline Ramirez Alvarado, Lina Moreno Gómez, Alana Von Glasenapp, Andrea Noboa, Henry Idrobo, Juan Ospina Idarraga, Christine Rojas, Judith Pineda, Cristian Seehaus, Guillermina Remaggi, Sofia Sanchez, Ramiro Espinoza, Martha Alvarado, Jose Antonio De la Peña-Celaya, Juan Manuel Perez, Luara L. Arana-Luna, María Eugenia Espitia, Eleazar Hernandez, Lourdes David Salas, Evelyn Herrera
Journal: Blood (2020)
Oral vesiculobullous lesions as an early sign of COVID‐19: immunohistochemical detection of SARS‐CoV‐2 spike protein
Authors: C.D. Soares, A. Mosqueda‐Taylor, M.G.F. Carvalho, O.P. Almeida
Journal: British Journal of Dermatology (2020)

Oral vesiculobullous lesions as
A Phase 1 Single Dose Escalation Study of Palifermin Administered Pre-Transplant Conditioning in Subjects Undergoing Matched Unrelated Donor Allogeneic Hematopoietic Stem Cell Transplantation
Authors: Alen Ostojic, Noa G. Holtzman, Lauren M. Curtis, Brian C. Shaffer, Jeffrey S Rubin, Frances T. Hakim, Jacqueline W Mays, Theo Heller, Edward W Cowen, Sabine Werner, Michael Emanuel, Seth M. Steinberg, Ronald E. Gress, Steven Z. Pavletic
Journal: Blood (2020)
Abstract 12946: Mid- To Late-life Systemic Inflammation and Incidence of Heart Failure With Preserved (HFpEF) and Reduced Ejection Fraction (HFrEF) in Late-Life: The Atherosclerosis Risk in Communities (ARIC) Study
Authors: Aaron J Cohen, Kanako Teramoto, Jenine E John, Brian Claggett, Leo F Buckley, Scott D Solomon, Christie M Ballantyne, Elizabeth Selvin, Amil M Shah
Journal: Circulation (2019)

Introduction: Inflammation is associated with heightened risk of heart failure (HF), but little data is available regarding the influence of mid- to late-life inflammation on late-life HF risk, and...
Quality of Life (QoL) and Clinical Outcomes in Patients with Relapsed/Refractory Multiple Myeloma (RRMM) Receiving Ixazomib-Lenalidomide-Dexamethasone (IRd) in a Real-World Setting
Authors: Tatyana Ionova, Elena Ado, Lyudmila Anchukova, Elena Babich, Dolgorzhap Dasheeva, Marina Demchenkova, Sergei Dubov, Tatiana Esenina, Lyudmila Ivanova, Kamil Kaplanov, Anna Kopylova, Yulia Kochkareva, Tatiana Kravchuk, Alexander Levanov, Olga Li, Tatiana Mitina, Tatiana Nikitina, Natalia Porfirieva, Elena Rimashevskaya, Oleg Rukavitsyn, Natalia Saraeva, Marina Savinova, Tatiana Shelekhova, Polina Simashova, Mariya Shirokova, Olga Vinogradova, Svetlana Volkova, Anna Zinkovskaya
Journal: Blood (2020)
Clinical Outcomes Among Real-World Patients with Chronic Lymphocytic Leukemia (CLL) Initiating First-Line Ibrutinib or Chemoimmunotherapy (CIT) Stratified By Risk Status: Results from a US Retrospective Chart Review Study
Authors: Qing Huang, Kathleen L Deering, Qing Harshaw, Tarun Bhagnani, Lori A. Leslie
Journal: Blood (2020)
Incidence of influenza during pregnancy and association with pregnancy and perinatal outcomes in three middle-income countries: a multisite prospective longitudinal cohort study
Authors: Fatimah S Dawood, Wanitchaya Kittikraisak, Archana Patel, Danielle Rentz Hunt, Piyarat Suntarattiwong, Meredith G Wesley, Mark G Thompson, Giselle Soto, Shailendra Mundhada, Carmen S Arriola, Eduardo Azziz-Baumgartner, Tana Brummer, Santiago Cabrera, Howard H Chang, Madhavi Deshmukh, Damon Ellison, Richard Florian, Oswaldo Gonzales, Kunal Kurhe, Surasak Kaoiean, Boonsong Rawangban, Stephen Lindstrom, Edwin Llajaruna, Joshua A Mott, Siddhartha Saha, Amber Prakash, Sarita Mohanty, Chalinthorn Sinthuwattanawibool, Yeny Tinoco
Journal: The Lancet Infectious Diseases (2020)
Patient-Reported Outcomes Among Patients with High-Risk Untreated Follicular Lymphoma (FL) Randomized to Bendamustine/Rituximab (BR) or Bendamustine/Rituximab with Bortezomib (BVR) Therapy: Results from the ECOG-ACRIN E2408 Study
Authors: Giselle K. Perez, Fangxin Hong, Andrew M. Evens, Thomas M. Habermann, Ranjana Advani, Stephen M. Ansell, Puneet S. Cheema, Philip A. Dy, Timothy E. O'Brien, Jane N. Winter, Julie E. Chang, David Cella, Brad S. Kahl, Lynne I. Wagner
Journal: Blood (2020)
The Potential Role of Therapeutic Dose of Low Molecular Weight Heparin (LWMH) to Attenuate Hyper-Inflammatory State in Hospitalized COVID-19 Patients
Authors: Mohsin Sheraz Mughal, Ikwinder Preet Kaur, Ali R. Jaffery, Chang Wang, Muhammad Asif, Anthony J. Ricca, Doantrang T. Du, Chandler D. Patton, Kenneth Granet
Journal: Blood (2020)
<i>Long-Term Outcome of Chronic Phase Chronic Myeloid Leukemia Patients Treated with Nilotinib Front-Line</i>
Authors: Franck E Nicolini, Vincent Alcazer, Pascale Cony-Makhoul, Stephanie Dulucq, Sandrine Hayette, Stephane Morisset, Jean-Michel Cayuela, Marie-Pierre Fort, Christophe Bouvier, Clemence Deteix-Santana, Etienne Lengline, Delphine Rea, Francois-Xavier Mahon, Gabriel Etienne
Journal: Blood (2020)
High-Density Data Mining to Identify Unique Toxicities of Adolescent/Young Adult Cancer Treatment: A Report from the Children's Oncology Group
Authors: Mayur Sarangdhar, Susan L. Whiteway, Jessica L. Heath, Elizabeth A. Raetz, Emily Hibbits, Meenakshi Devidas, David R. Freyer, John Peter Perentesis
Journal: Blood (2017)
Rates of recurrent positive SARS-CoV-2 swab results among patients attending primary care in Qatar
Authors: Ehab Hamed, Saad Sedeeq, Ahmed Sameer Alnuaimi, Mohamed Syed, Mohamed Abd ElHamid, Bayan Alemrayat, Amina Mukhtar, AlAnoud AlFehaidi, Hamda A/Qotba
Journal: Journal of Infection (2020)
HMGB1 increases radiosensitivity by interacting with HDAC1
Authors: Yang Jiao, Chunmin Ge, Qinghui Meng, Haicao Wang, Saijun Fan
Journal: Cancer Research (2007)

3114  HMGB1 (high mobility group box 1 is an important nuclear protein responding to the body’s inflammatory, ischemia and injury. In this study, we found that increased expression of HMGB1 enhances susceptibility of breast cancer cells to ionizing radiation, while decreased expression reduced the sensitivity. We also demonstrated that HMGB1 associated with the histone deacetylase HDAC1, an important mediator in DNA damage repair pathway. A LXCXE motif of HMGB1 was required for HDAC1 binding, HMGB1 with mutant LXCXE motif failed to interact with HDAC1. Furthermore, the HMGB1 binding to HDAC1 was significantly increased by ionizing radiation. HDAC1 inhibitors significantly increased HMGB1 radiosensitization. These results suggest an important mechanism contributing to HMGB1 radiosensitivity by interacting with HDAC1.
Estimated Association of Construction Work With Risks of COVID-19 Infection and Hospitalization in Texas
Authors: Remy F. Pasco, Spencer J. Fox, S. Claiborne Johnston, Michael Pignone, Lauren Ancel Meyers
Journal: JAMA Network Open (2020)

<h3>Importance</h3> Policy makers have relaxed restrictions for certain nonessential industries, including construction, jeopardizing the effectiveness of social distancing measures and putting already at-risk populations at greater risk of coronavirus disease 2019 (COVID-19) infection. In Texas, Latinx populations are overly represented among construction workers, and thus have elevated rates of exposure that are compounded by prevalent high-risk comorbidities and lack of access to health care. <h3>Objective</h3> To assess the association between construction work during the COVID-19 pandemic and hospitalization rates for construction workers and the surrounding community. <h3>Design, Setting, and Participants</h3> This decision analytical model used a mathematical model of COVID-19 transmission, stratified by age and risk group, with construction workers modeled explicitly. The model was based on residents of the Austin–Round Rock metropolitan statistical area, with a population of 2.17 million. Based on 500 stochastic simulations for each of 15 scenarios that varied the size of the construction workforce and level of worksite transmission risk, the association between continued construction work and hospitalizations was estimated and then compared with anonymized line-list hospitalization data from central Texas through August 20, 2020. <h3>Exposures</h3> Social distancing interventions, size of construction workforce, and level of disease transmission at construction worksites. <h3>Main Outcomes and Measures</h3> For each scenario, the total number of COVID-19 hospitalizations and the relative risk of hospitalization among construction workers was projected and then compared with relative risks estimated from reported hospitalization data. <h3>Results</h3> Allowing unrestricted construction work was associated with an increase of COVID-19 hospitalization rates through mid-August 2020 from 0.38 per 1000 residents to 1.5 per 1000 residents and from 0.22 per 1000 construction workers to 9.3 per 1000 construction workers. This increased risk was estimated to be offset by safety measures (such as thorough cleaning of equipment between uses, wearing of protective equipment, limits on the number of workers at a worksite, and increased health surveillance) that were associated with a 50% decrease in transmission. The observed relative risk of hospitalization among construction workers compared with other occupational categories among adults aged 18 to 64 years was 4.9 (95% CI, 3.8-6.2). <h3>Conclusions and Relevance</h3> The findings of this study suggest that unrestricted work in high-contact industries, such as construction, is associated with a higher level of community transmission, increased risks to at-risk workers, and larger health disparities among members of racial and ethnic minority groups.
Molecular Response Patterns in Hydroxyurea (HU)-Resistant or Intolerant Polycythemia Vera (PV) during Treatment with Idasanutlin: Results of an Open-Label, Single-Arm Phase 2 Study
Authors: Francesco Passamonti, Kate Burbury, Tarec Christoffer El-Galaly, Aaron T. Gerds, Vikas Gupta, Brian Higgins, Ling-Yuh Huw, Margherita Maffioli, Ruben Mesa, Jeanne M. Palmer, Alessandro Rambaldi, David M Ross, Alessandro M. Vannucchi, Abdulraheem Yacoub, John Mascarenhas
Journal: Blood (2020)