tbuckley/cabot-search huggingface dataset:
Survival of the fittest?
Authors: M. Black
Journal: BMJ (2010)

<h3>ABSTRACT</h3> <h3>Introduction</h3> How cigarette smoke (CS) and chronic obstructive pulmonary disease (COPD) affect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and severity is controversial. We investigated the protein and mRNA expression of SARS-CoV-2 entry receptor ACE2 and proteinase TMPRSS2 in lungs from COPD patients and controls, and lung tissue from mice exposed acutely and chronically to CS. Also, we investigated the effects of CS exposure on SARS-CoV-2 infection in human bronchial epithelial cells. <h3>Methods</h3> In Cohort 1, ACE2-positive cells were quantified by immunostaining in FFPE sections from both central and peripheral airways. In Cohort 2, we quantified pulmonary ACE2 protein levels by immunostaining and ELISA, and both ACE2 and TMPRSS2 mRNA levels by RT-qPCR. In C57BL/6 WT mice exposed to air or CS for up to 6 months, pulmonary ACE2 protein levels were quantified by triple immunofluorescence staining and ELISA. The effects of CS exposure on SARS-CoV-2 infection were evaluated after 72hr in vitro infection of Calu-3 cells. After SARS-CoV-2 infection, the cells were fixed for IF staining with dsRNA-specific J2 monoclonal Ab, and cell lysates were harvested for WB of viral nucleocapsid (N) protein. Supernatants (SN) and cytoplasmic lysates were obtained to measure ACE2 levels by ELISA. <h3>Results</h3> In both human cohorts, ACE2 protein and mRNA levels were decreased in peripheral airways from COPD patients versus both smoker and NS controls, but similar in central airways. TMPRSS2 levels were similar across groups. Mice exposed to CS had decreased ACE2 protein levels in their bronchial and alveolar epithelia versus air-exposed mice exposed to 3 and 6 months of CS. In Calu3 cells in vitro, CS-treatment abrogated infection to levels below the limit of detection. Similar results were seen with WB for viral N protein, showing peak viral protein synthesis at 72hr. <h3>Conclusions</h3> ACE2 levels were decreased in both bronchial and alveolar epithelial cells from uninfected COPD patients versus controls, and from CS-exposed versus air-exposed mice. CS-pre-treatment did not affect ACE2 levels but potently inhibited SARS-CoV-2 replication in this in vitro model. These findings urge to further investigate the controversial effects of CS and COPD on SARS-CoV2 infection.
SAFETY AND EFFICACY OF ANTIREFLUX ABLATION THERAPY (ARAT) AT THE ESOPHAGOGASTRIC JUNCTION (EGJ) IN PATIENTS WITH GASTROESOPHAGEAL REFLUX DISEASE (GERD) WITHOUT HIATAL HERNIA
Authors: OVH Mondragón, RA Gutierrez Aguilar, LF Garcia Contreras, OMS Pineda, G Blanco Velasco, E Murcio Perez
Journal: Endoscopy (2020)

Aims GERD is a high-prevalent condition with potential severe complications. Medical and surgical treatments are the cornerstone; however, adverse events or complications limit their use. We hypothesize that an esophagogastric-junction(EGJ) controlled stenosis generated with a mucosal ablation(Antireflux ablation therapy[ARAT]), could decrease esophageal exposure to gastric contents. Therefore, our aim was to evaluate the safety and efficacy of ARAT in GERD treatment at early and mid-term.
Liver function and prognosis, and influence of sacubitril/valsartan in patients with heart failure with reduced ejection fraction
Authors: Kota Suzuki, Brian Claggett, Masatoshi Minamisawa, Milton Packer, Michael R. Zile, Jean Rouleau, Karl Swedberg, Martin Lefkowitz, Victor Shi, John J.V. McMurray, Stephen D. Zucker, Scott D. Solomon
Journal: European Journal of Heart Failure (2020)
Cost-Effectiveness Analysis of Stress Cardiovascular Magnetic Resonance Imaging for Stable Chest Pain Syndromes
Authors: Yin Ge, Ankur Pandya, Kevin Steel, Scott Bingham, Michael Jerosch-Herold, Yi-Yun Chen, J. Ronald Mikolich, Andrew E. Arai, W. Patricia Bandettini, Amit R. Patel, Afshin Farzaneh-Far, John F. Heitner, Chetan Shenoy, Steve W. Leung, Jorge A. Gonzalez, Dipan J. Shah, Subha V. Raman, Victor A. Ferrari, Jeanette Schulz-Menger, Rory Hachamovitch, Matthias Stuber, Orlando P. Simonetti, Raymond Y. Kwong
Journal: JACC. Cardiovascular imaging (2020)
ENDOSCOPIC TREATMENT OF CAUSTIC STENOSIS: ABOUT 42 CASES
Authors: M Borahma, N Lagdali, C Berhili, I Benelbarhdadi, FZ Ajana
Journal: Endoscopy (2020)

Aims Ingestion of a corrosive substance causes esophageal lesions of varying severity. The endoscopic assessment allows to make the inventory of digestive lesions that condition the prognosis and guide the therapeutic strategy. Treatment of esophageal stenosis, once organized, involves endoscopic treatment (dilatation) and/or surgery. Our work aimed to report, through a retrospective analysis, the experience of our department concerning the endoscopic treatment of caustic stenosis.
FIT BUT AIMING FOR ‘FITTER’ AT A NHS UNIVERSITY DISTRICT GENERAL HOSPITAL FOR TARGET REFERRALS
Authors: IE Zayat, F Akinlade, A Siddiqui, L Neeves, S Banerjee
Journal: Endoscopy (2020)

Aims FIT replaces gFOBT for the detection of faecal occult blood in low risk symptomatic patients (NICE DG30) and in the bowel cancer screening programme (BCSP). The aim was to review the outcomes of FIT with regards to two week wait referrals via loco-regional GP practices between June - August 2019, paying particular attention to the number of confirmed colorectal cancer cases. We also compared the outcomes of FIT with gFOBT in the BCSP.
A MiR-31-dependent Loss of Dystrophin & Nnos in the Human Atria Plays a Key Role in Atrial Fibrillation-induced Electrical Remodelling
Authors: S Reilly, X Liu, R Carnicer, T Rajakumar, R Sayeed, G Krasopoulos, S Verheule, T Fulga, U Schotten, B Casadei
Journal: Circulation (2014)
CASE REPORT: RECURRENT UGIB SECONDARY TO A PANCREATICODUODENAL PSEUDOANEURYSM - ROLE OF EUS IN THE DIAGNOSIS AND MANAGEMENT
Authors: M Zaho, B Maher, N Tehami
Journal: Endoscopy (2020)

Aims Aneurysms of the pancreaticoduodenal artery (PDA) are extremely rare, with a reported incidence of 1-2% amongst all splanchnic artery aneurysms.
BARRETT’S SURVEILLANCE: IS A FULL GASTROSCOPY REQUIRED?
Authors: A Ghodeif, S Afify, M Mathew, M Thoufeeq
Journal: Endoscopy (2020)

Aims To assess if a full gastroscopy would detect significant finding on repeated endoscopic examinations of patients undergoing Barrett’s surveillance or it could be sufficient to focus on Barrett’s examination with more dedicated time and examination techniques to the oesophageal pathology.
Nivolumab and dinutuximab beta in two patients with refractory neuroblastoma
Authors: Karoline Ehlert, Ina Hansjuergens, Andreas Zinke, Sylke Otto, Nikolai Siebert, Guenter Henze, Holger Lode
Journal: Journal for ImmunoTherapy of Cancer (2020)

Background Neuroblastoma (NB) is the most frequent extracranial solid tumor in children. More than 50% of patients present with widespread (stage M) or refractory disease. In these patients, event-free and overall survival was improved by the addition of the anti-disialoganglioside antibody dinutuximab beta (DB) following multimodal conventional therapy. However, the prognosis of patients with refractory/relapsed NB remains poor. In the past decade, immunotherapy approaches with checkpoint inhibitors were approved for patients with certain malignant diseases such as melanoma or Hodgkin lymphoma. In preclinical models, DB resulted in an upregulation of the programmed cell death protein 1 (PD-1) checkpoint in NB cell lines and a combined treatment of DB with a murine anti-PD-1 checkpoint inhibitor showed a synergistic effect in a NB mouse model. Case presentations Two patients were admitted with refractory metastatic NB. In the 4-year-old girl, NB was diagnosed in 2013. She completed her first-line therapy with a first remission in 2015, but suffered a relapse in 2017. Treatment with chemotherapy and DB resulted in progressive disease after transient improvement. In the 17-year-old young man, NB was first diagnosed in April 2010. After two local relapses in 2011 and 2014, a metastatic relapse and a large abdominal tumor bulk were found in 2018. Despite transient improvement with multimodal therapy, progressive metastatic disease was observed in May 2019. Both patients had a satisfactory quality of life. Therefore, treatment with DB and nivolumab was performed—in the girl from October 2018 until August 2019, in the young man since June 2019. Tolerance to treatment was excellent. The girl continues to be in complete remission 6 months after therapy was stopped. In the young man, the soft tissue lesions disappeared completely, the skeletal lesions regressed substantially after 9 months of his still ongoing treatment. Conclusions The combination of DB with the checkpoint inhibitor nivolumab led to complete and a very good partial remission in two patients with relapsed/refractory NB. Prospective trials are warranted to clarify the role of this novel approach in a larger number of patients.
EXPERIENCE WITH ENDOROTORXT FOR ENDOSCOPIC NECROSECTOMY IN PATIENTS WITH ACUTE NECROTIC PANCREATITIS AT A TERTIARY CARE CENTER
Authors: K Soota, MM. Abdelfatah, S Peter, C.M Wilcox, KR K.K. Baig, A Ahmed
Journal: Endoscopy (2020)

Aims Acute necrotic pancreatitis is a devastating disease with mortality rates ranging from 26 - 86%. Recent development of a lumen apposing metal stent (LAMS) has improved endoscopic therapies but is limited by the lack of dedicated endoscopic tools. The EndoRotor XT is a novel mechanical endoscopic debridement system designed for this purpose. So far only 2 cases of pancreatic necrosis treated by EndoRotor have been described in the literature.
Endoscopic diagnosis and management of chronic relapsing pancreatitis due to eroded embolization coils
Authors: Wesam M. Frandah, Nicolas Fiore, Merall Sherif, Saad Emhmed Ali, Ahmed M. Sherif
Journal: Endoscopy (2020)

A 59-year-old man with alcohol-induced pancreatitis was referred due to dilated pancreatic duct and pancreatic mass. He had presented 9 years earlier with gastrointestinal bleeding secondary to hemosuccus pancreaticus, which was treated by interventional radiology-guided coil and glue application to the superior pancreatico-duodenal artery pseudoaneurysm. He had complained of postprandial upper abdominal pain and a 10-lb weight loss, and had experienced recurrent acute pancreatitis in the preceding 4 months. Contrast-enhanced computed tomography showed dilated pancreatic duct and multiple coils around the head of the pancreas, and extensive shadowing artifact precluded further evaluation.
Growth Rate Patterns of Solid Tumors and Their Relation to Responsiveness to Therapy
Authors: STANLEY E. SHACKNEY
Journal: Annals of Internal Medicine (1978)

The clinical doubling times of human solid tumors are reviewed. Methods are also described for estimating subclinical tumor doubling times, and these methods are applied to Wilms' tumor, choriocarcinoma, Burkitt's tumor, and breast cancer. Rapidly growing tumors are often responsive to therapy, and such complete responses are often quite durable. Slowly growing tumors respond less favorably to therapy, and responses are generally not durable. Rapidly growing tumors in advanced stages are similar in their response behavior to the slowly growing tumors. A strategy based on cell kinetics principles and tumor doubling time data is proposed for improving therapeutic results in responsive tumors. Data on clinical and subclinical tumor doubling times are used to distinguish early recurrences from late recurrences in a given tumor type. Early recurrences call for intensification of induction therapy, whereas late recurrences call for prolongation of consolidative therapy. This strategy may also apply in adjuvant therapy of slowly growing tumors.
DUODENO-BILIARY FISTULA CLOSING WITH NAGI LUMINAL APPOSING METAL STENT
Authors: S Bazaga, E Pijoan, I Miguel, M Alburquerque, A Vargas, N Torres, L Guerrero, C Aracil, JA Rodiguez, F Gonzalez-Huix
Journal: Endoscopy (2020)

83-year-old man who underwent gastroscopy, which showed a 5–6 mm fistula orifice in duodenal bulb. With radiological control, placed a balloon occlude fistula orifice, checking that there was a 2 cm small cavity that drained through percutaneous drainage for cholecystitis. We passed off a 0.035wire into the cavity. A NAGI luminal-apposing metal stent placed. This stent turns the external fistula into internal (duodenal-perihiliar cavity). Gallbladder drainage was clamped and finally removing by the clinical improvement drainage. Patient did not present biliary obstruction symptoms. A gastroscopy was performed in 6 weeks, showed a little cavity with hyperplasic mucosa. Stent removed without complications.
MULTICENTER PROSPECTIVE RANDOMIZED STUDY TO COMPARE ENDOSCOPIC TREATMENT OF STRICTURES IN CROHN´S DISEASE (CD): SELF-EXPANDING METAL STENTS (SEMS) VS ENDOSCOPIC BALLOON DILATION (EBD). PROTDILAT STUDY
Authors: X Andújar, C Loras, JB Gornals, J Guardiola, V Sanchiz, M Bosca, E Brullet, B Sicilia, A Naranjo, C Dueñas, JR Foruny, D Busquets, D Monfort, MD Martín-Arranz, J Barrio, JR Pineda, F González-Huix, F Pérez-Roldán, V Pons, B González, E Sainz, J Reyes-Moreno, F Fernández-Bañares, M Esteve
Journal: Endoscopy (2020)

Aims: Introduction EBD is the established endoscopic treatment for short strictures in CD. SEMS have been used for endoscopic treatment in patients that failed to dilation.
Genomic Epidemiology, Evolution, and Transmission Dynamics of Porcine Deltacoronavirus
Authors: Wan-Ting He, Xiang Ji, Wei He, Simon Dellicour, Shilei Wang, Gairu Li, Letian Zhang, Marius Gilbert, Henan Zhu, Gang Xing, Michael Veit, Zhen Huang, Guan-Zhu Han, Yaowei Huang, Marc A Suchard, Guy Baele, Philippe Lemey, Shuo Su
Journal: Molecular Biology and Evolution (2020)

Abstract The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown once again that coronavirus (CoV) in animals are potential sources for epidemics in humans. Porcine deltacoronavirus (PDCoV) is an emerging enteropathogen of swine with a worldwide distribution. Here, we implemented and described an approach to analyze the epidemiology of PDCoV following its emergence in the pig population. We performed an integrated analysis of full genome sequence data from 21 newly sequenced viruses, along with comprehensive epidemiological surveillance data collected globally over the last 15 years. We found four distinct phylogenetic lineages of PDCoV, which differ in their geographic circulation patterns. Interestingly, we identified more frequent intra- and interlineage recombination and higher virus genetic diversity in the Chinese lineages compared with the USA lineage where pigs are raised in different farming systems and ecological environments. Most recombination breakpoints are located in the ORF1ab gene rather than in genes encoding structural proteins. We also identified five amino acids under positive selection in the spike protein suggesting a role for adaptive evolution. According to structural mapping, three positively selected sites are located in the N-terminal domain of the S1 subunit, which is the most likely involved in binding to a carbohydrate receptor, whereas the other two are located in or near the fusion peptide of the S2 subunit and thus might affect membrane fusion. Finally, our phylogeographic investigations highlighted notable South-North transmission as well as frequent long-distance dispersal events in China that could implicate human-mediated transmission. Our findings provide new insights into the evolution and dispersal of PDCoV that contribute to our understanding of the critical factors involved in CoVs emergence.
DEVELOPMENT OF MACHINE LEARNING MODELS TO PREDICT RISK OF PATHOLOGY OR NEED FOR INTERVENTION AMONGST ADULT PATIENTS UNDERGOING COLONOSCOPY
Authors: M Stammers, S Thayalasekaran, M Abdelrahim, P Bhandari
Journal: Endoscopy (2020)

Aims Background The number of colonoscopies performed yearly is constantly increasing around Europe. Accordingly, endoscopy services are coming under huge service-delivery pressure, and waiting times are becoming unacceptable; This calls for better risk-stratification.
Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium
Authors: Bartomeu Colom, Maria P. Alcolea, Gabriel Piedrafita, Michael W. J. Hall, Agnieszka Wabik, Stefan C. Dentro, Joanna C. Fowler, Albert Herms, Charlotte King, Swee Hoe Ong, Roshan K. Sood, Moritz Gerstung, Inigo Martincorena, Benjamin A. Hall, Philip H. Jones
Journal: Nature Genetics (2020)
Tablet and web-based audiometry to screen for hearing loss in adults with cystic fibrosis
Authors: Anitha Vijayasingam, Emily Frost, Julie Wilkins, Lise Gillen, Presanna Premachandra, Kate Mclaren, Desmond Gilmartin, Lorenzo Picinali, Alberto Vidal-Diez, Simone Borsci, Melody Zhifang Ni, Wai Y Tang, Deborah Morris-Rosendahl, Jonny Harcourt, Caroline Elston, N J Simmonds, Anand Shah
Journal: Thorax (2020)

Individuals with chronic lung disease (eg, cystic fibrosis (CF)) often receive antimicrobial therapy including aminoglycosides resulting in ototoxicity. Extended high-frequency audiometry has increased sensitivity for ototoxicity detection, but diagnostic audiometry in a sound-booth is costly, time-consuming and requires a trained audiologist. This cross-sectional study analysed tablet-based audiometry (Shoebox MD) performed by non-audiologists in an outpatient setting, alongside home web-based audiometry (3D Tune-In) to screen for hearing loss in adults with CF.Hearing was analysed in 126 CF adults using validated questionnaires, a web self-hearing test (0.5 to 4 kHz), tablet (0.25 to 12 kHz) and sound-booth audiometry (0.25 to 12 kHz). A threshold of ≥25 dB hearing loss at ≥1 audiometric frequency was considered abnormal. Demographics and mitochondrial DNA sequencing were used to analyse risk factors, and accuracy and usability of hearing tests determined.Prevalence of hearing loss within any frequency band tested was 48%. Multivariate analysis showed age (OR 1.127; (95% CI: 1.07 to 1.18; p value<0.0001) per year older) and total intravenous antibiotic days over 10 years (OR 1.006; (95% CI: 1.002 to 1.010; p value=0.004) per further intravenous day) were significantly associated with increased risk of hearing loss. Tablet audiometry had good usability, was 93% sensitive, 88% specific with 94% negative predictive value to screen for hearing loss compared with web self-test audiometry and questionnaires which had poor sensitivity (17% and 13%, respectively). Intraclass correlation (ICC) of tablet versus sound-booth audiometry showed high correlation (ICC >0.9) at all frequencies ≥4 kHz.Adults with CF have a high prevalence of drug-related hearing loss and tablet-based audiometry can be a practical, accurate screening tool within integrated ototoxicity monitoring programmes for early detection.
CHANGHAI ADVANCED ENDOSCOPY COURSES FOR ERCP TRAINING PROGRAM (CHANCE): A SHORT-TERM TRAINING MODEL IN CHINA
Authors: D Zhang, D Wang, TJ Wang, L Xin, ZS Li, LH Hu
Journal: Endoscopy (2020)

Aims There is a huge shortage of ERCP practitioners (ERCPists) in China, and ERCP training is urgently needed. ChangHai Advanced eNdoscopy Courses for ERCP (CHANCE) is a 4-month program for ERCP training since 2004. This study evaluated the efficiency of this short-term training model, and reported on the ERCP careers of the trainees following completion of the CHANCE program.
Dense biased networks with deep priori anatomy and hard region adaptation: Semi-supervised learning for fine renal artery segmentation
Authors: Yuting He, Guanyu Yang, Jian Yang, Yang Chen, Youyong Kong, Jiasong Wu, Lijun Tang, Xiaomei Zhu, Jean-Louis Dillenseger, Pengfei Shao, Shaobo Zhang, Huazhong Shu, Jean-Louis Coatrieux, Shuo Li
Journal: Medical Image Analysis (2020)
IMPROVING ENDOSCOPIC ASSESSMENT AND MANAGEMENT OF LARGE NON-PEDUNCOLATED COLORECTAL LESIONS IN A WESTERN CENTER OVER 10 YEARS: LESSONS LEARNT AND IMPACT ON PATIENTS’ OUTCOMES
Authors: G Vanella, C Coluccio, G Antonelli, S Angeletti, F Micheli, A Barbato, G De Rossi, A Marchetti, E Mereu, P Pepe, VD Corleto, G D’Ambra, M Ruggeri, E Di Giulio
Journal: Endoscopy (2020)

Aims Outcomes of endoscopic management of large colorectal (CR) non-pedunculated lesions (LNPLs) are still under evaluation, especially in Western settings. We analysed the clinical impact of changes in LNPLs’ management over the last decade in a European center.
ESD ALLOWS BETTER STRATIFICATION OF METASTATIC RISK IN NON-PEDUNCULATED PT1 COLORECTAL CANCER: A SINGLE CENTRE RETROSPECTIVE STUDY
Authors: R Sassatelli, M Lucarini, P Cecinato, V Iori, VG Mirante, L De Marco, S Arona, F Bassi, M Campanale, M Cavina, F Decembrino, S Grillo, F Parmeggiani, G Sereni, C Tioli, R Zecchini
Journal: Endoscopy (2020)

Aims To compare the effectiveness of endoscopic submucosal dissection (ESD) and endoscopic mucosal resection (EMR) in T1 colorectal cancer (CRC) treatment.
Phase I/II Study of CPX-351 Followed by Fludarabine, Cytarabine, and Granulocyte-Colony Stimulating Factor for Children With Relapsed Acute Myeloid Leukemia: A Report From the Children’s Oncology Group
Authors: Todd M. Cooper, Michael J. Absalon, Todd A. Alonzo, Robert B. Gerbing, Kasey J. Leger, Betsy A. Hirsch, Jessica Pollard, Bassem I. Razzouk, Richard Aplenc, E. Anders Kolb
Journal: Journal of Clinical Oncology (2020)

Effective regimens are needed for children with relapsed acute myeloid leukemia (AML). AAML1421 is a phase I/II study of CPX-351, a liposomal preparation of daunorubicin and cytarabine. AAML1421 sought to determine the recommended phase II dose (RP2D) of CPX-351 and the response rate after up to 2 cycles of therapy.Children > 1 and ≤ 21 years of age with relapsed/refractory AML were eligible for dose finding; those in first relapse were eligible for the efficacy phase. Dose-limiting toxicity (DLT) assessment occurred during cycle 1. Two cycles of therapy were offered (cycle 1: CPX-351; cycle 2: FLAG [fludarabine 30 mg/m2/dose on days 1-5; cytarabine 2,000 mg/m2/dose on days 1-5; and granulocyte-colony stimulating factor 5 µg/kg/dose, days 1-5 and day 15 through absolute neutrophil count > 500/µL]). Response was assessed after each cycle.Thirty-eight patients enrolled: 6 in the dose-finding phase and 32 in the efficacy phase. During dose finding, 1/6 patients experienced a DLT (grade 3 decrease in ejection fraction). The RP2D was 135 units/m2 on days 1, 3, and 5. Toxicities of grade ≥ 3 during cycle 1 included fever/neutropenia (45%), infection (47%), and rash (40%). There was no toxic mortality. Best responses included 20 complete response (CR; 54%), 5 CR with partial recovery of platelet count (CRp; 14%), and 5 CR with incomplete blood count recovery (14%). Twenty-one of 25 with CR/CRp had no detectable residual disease (RD; 84%) by flow cytometry. Hematopoietic stem cell transplantation (HSCT) was used as consolidation in 29/30 responders (96.7%); 20/25 (80%) had no RD before HSCT.The RP2D of CPX-351 is 135 units/m2/dose on days 1, 3, and 5. Toxicity was manageable, and protocol therapy was effective. Response rates are superior to prior published North American cooperative group clinical trials for children with AML in first relapse.
Didanosine Compared with Continuation of Zidovudine in HIV-infected Patients with Signs of Clinical Deterioration While Receiving Zidovudine
Authors: Spotswood L. Spruance, Andrew T. Pavia, Dolores Peterson, Allison Berry, Richard Pollard, Thomas F. Patterson, Ian Frank, Scot C. Remick, Melanie Thompson, Rodger D. MacArthur, G. E. Morey, Carlos H. Ramirez-Ronda, Barry M. Bernstein, Donna E. Sweet, Lawrence Crane, Eskild A. Peterson, Constance T. Pachucki, Stephen L. Green, Jerry Brand, Adan Rios, Lisa M. Dunkle, Anne Cross, Michael J. Brown, Peter Ingraham, Ronald Gugliotti, Andrew H. Schindzielorz, Laurie Smaldone
Journal: Annals of Internal Medicine (1994)

Objective: To determine the benefits of switching to didanosine compared with continuing zidovudine among patients infected with human immunodeficiency virus (HIV) who have previously used zidovudi...