tbuckley/cabot-search huggingface dataset:
Influence of Killer Immunoglobulin-Like Receptor (KIR) Matching on Achieving T Cell (CD3+) Complete Donor Chimerism (CDC) in Related Donor Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation (NMHSCT).
Authors: Ronald Sobecks, Edward J. Ball, Medhat Askar, Karl Theil, Lisa Rybicki, Dawn Thomas, Jennifer Bates, Matt Kalaycio, Steven Andresen, Brad Pohlman, Robert M. Dean, John William Sweetenham, Laura Bernhard, Kelly Cherni, Jaroslaw P. Maciejewski, Brian J. Bolwell
Journal: Blood (2006)
SIRPα expression delineates subsets of intratumoral monocyte/macrophages with different functional and prognostic impact in follicular lymphoma
Authors: Ya-Ping Chen, Hyo Jin Kim, Hongyan Wu, Tammy Price-Troska, Jose C. Villasboas, Shahrzad Jalali, Andrew L. Feldman, Anne J. Novak, Zhi-Zhang Yang, Stephen M. Ansell
Journal: Blood Cancer Journal (2019)

Signal regulatory protein-α (SIRPα) is a key member of the "do-not-eat-me" signaling pathway, but its biological role and clinical relevance in B-cell NHL is relatively unknown. Using biopsy specimens from follicular lymphoma (FL), we identified three subsets (CD14+SIRPαhi, CD14-SIRPαlow, and CD14-SIRPαneg) of monocyte/macrophages (Mo/MΦ) based on CD14 and SIRPα expression. CD14+SIRPαhi cells expressed common Mo/MΦ markers; exhibited characteristic differentiation, migration, and phagocytosis; and suppressed T-cell function. CD14-SIRPαlow cells expressed fewer typical Mo/MΦ markers; migrated less and phagocytosed tumor cells less efficiently; and stimulated rather than suppressed T-cell function. Interestingly, the CD14-SIRPαneg subset expressed distinct Mo/MΦ markers compared to the other two subsets; had limited ability to migrate and phagocytose; but stimulated T-cell function. When using SIRPα-Fc to block the interaction between SIRPα and CD47, alone or in combination with rituximab, phagocytosis of tumor cells was differentially increased in the three Mo/MΦ subsets. Clinically, increased numbers of CD14+SIRPαhi cells were associated with an inferior survival in FL. In contrast, increased numbers of the CD14-SIRPαlow subset appeared to correlate with a better survival. Taken together, our results show that SIRPα expression delineates unique subsets of intratumoral Mo/MΦs with differing prognostic importance.
Decreased Expression of CD62L and CD54 Correlates with Poor Cytogenetic Risk Group In Myelodysplastic Syndromes
Authors: Canan Alhan, Theresia M. Westers, Claudia Cali, Floortje L. Kessler, Monique Terwijn, Gert J. Ossenkoppele, Sonja Zweegman, Arjan A. Van de Loosdrecht
Journal: Blood (2010)
Update on JACCRO CC-11 trial of 1st-line modified-FOLFOXIRI plus bevacizumab for RAS mutant metastatic colorectal cancer
Authors: Masato Nakamura, Yu Sunakawa, Hiroyuki Okuyama, Masato Matsuura, Yuji Negoro, Taichi Yabuno, Takao Takahashi, Takao Tamura, Nobumichi Takeuchi, Hironaga Satake, Yuji Miyamoto, Masato Kataoka, Manabu Shiozawa, Akitaka Makiyama, Kazuma Kobayashi, Yutaro Kubota, Takashi Sekikawa, Masahiro Takeuchi, Wataru Ichikawa, Masashi Fujii
Journal: Annals of Oncology (2019)
Three Months of Human Haptoglobin Treatment Decreases Iron Deposition in the Kidneys of Townes Sickle Mice
Authors: Patricia A Shi, Erika Choi, Julia Nguyen, Xinhua Guo, Narla Mohandas, Abdu Alayash, Elizabeth Manci, John D. Belcher, Gregory M Vercellotti
Journal: Blood (2015)
Safety of PD-1/PD-L1 blockade in patients with preexisting positive antinuclear antibodies and autoimmune disease
Authors: Tomoki Sakakida, Takeshi Ishikawa, Yusuke Chihara, Sachi Harita, Junji Uchino, Yusuke Tabuchi, Satoshi Komori, Jun Asai, Tsukasa Narukawa, Tomoki Takata, Akihito Arai, Hiroaki Tsunezuka, Toshiyuki Kosuga, Hirotaka Konishi, Fumiya Hongo, Masayoshi Inoue, Shigeru Hirano, Osamu Ukimura, Yoshito Itoh, Tetsuya Taguchi, Koichi Takayama
Journal: Annals of Oncology (2019)
Antithymocyte Globulin (ATG) Plus Cyclosporine (CSA) for Aplastic Anemia (AA) and Low-Risk Myelodysplastic Syndrome (MDS).
Authors: Je-Hwan Lee, Seong-Jun Choi, Jung-Hee Lee, Miee Seol, Keun Hee Kim, Jae-Hoo Park, Hawk Kim, Young-Don Joo, Won-Sik Lee, Dae Young Zang, Hyo Jung Kim, Kyoo Hyung Lee
Journal: Blood (2006)
Reduced-Toxicity (RTC) Versus Myeloablative Conditioning (MAC) Prior to Allogeneic Stem Cell Transplantation in Pediatric Participants: Significant Improvement in Physical Functioning Following RTC Versus MAC
Authors: Jennifer A Oberg, Erin Morris, Lauren Harrison, Julia Glade Bender, James H Garvin, Stephen Sands, Mitchell S. Cairo
Journal: Blood (2011)
A Conserved Cis-Regulatory Retinoic Acid Responsive Element Is Essential for Maintenance of Primitive Hematopoietic Stem Cells through Regulation of Hoxb Cluster
Authors: Pengxu Qian, Youngwook Ahn, Bony De Kumar, Christof Nolte, Xi C. He, Ariel Paulson, John M. Perry, Zhenrui Li, Robb Krumlauf, Linheng Li
Journal: Blood (2015)
Treatment with a New Nitric Oxide Donor, a Hybrid Derived from Thalidomide and Hydroxycarbamide 3-(1,3-dioxoisoindolin-2-yl)Benzyl Nitrate, Reverses Priapism in the Sickle Cell Mouse and the Nitric Oxide-Deficient Mouse
Authors: Fabio Henrique Silva, Serkan Karakus, Biljana Musicki, Hotaka Matsui, Trinity J Bivalacqua, Jean L dos Santos, Arthut L Burnett, Fernando F Costa
Journal: Blood (2016)
Study of Lenalidomide Plus Dexamethasone Versus Dexamethasone Alone in Relapsed or Refractory Multiple Myeloma (MM): Results of a Phase 3 Study (MM-010).
Authors: Meletios A. Dimopoulos, Andrew Spencer, Michael Attal, Miles Prince, Jean-Luc Harousseau, Anna Dmoszynska, Zhinuan Yu, Marta Olesnyckyj, Jerome Zeldis, Robert Knight
Journal: Blood (2005)
Genome-Wide and Functional Analysis of Acquired Resistance to TRAIL/APO2l Mediated Apoptosis of Leukemia Cell Lines.
Authors: Jan Zivny, Pavel Klener, Pavel Prochazka, Sergiu Laehomschi, Ales Vicha, Tomas Eckschlager, Ladislav Andera, Emanuel Necas
Journal: Blood (2006)
Outcomes of Patients Treated with Matched and Mismatched Unrelated Donors Using High-Resolution HLA Typing at 12 Loci
Authors: Stefan O. Ciurea, Rima M. Saliba, Gabriela Rondon, Poliana A. Patah, Morgani Rodrigues, Fleur M. Aung, Borje S. Andersson, Simrit Parmar, Richard E. Champlin, Marcos de Lima, Marcelo Fernandez-Vina
Journal: Blood (2010)
Phase I/II Study of the Novel Combination of Panobinostat (LBH589) and Everolimus (RAD001) In Relapsed/Refractory Hodgkin and Non-Hodgkin Lymphoma
Authors: Anas Younes, Amanda Copeland, Michelle A. Fanale, Fredrick Hagemeister, Luis Fayad, Barbara Pro, Silvana C. Faria, Yuan Ji, L. Jeffrey Medeiros, Donald A Berry, Daniela Buglio
Journal: Blood (2010)
Characterization of Targets of Plitidepsin In JAK2V617F-Mutated Cells From Myeloproliferative Neoplasms
Authors: Paola Guglielmelli, Costanza Bogani, Niccolò Bartalucci, Lisa Pieri, Alessandro Pancrazzi, Alberto Bosi, Andrea Bisognin, Miguel Aracil, Stefania Bortoluzzi, Alessandro M. Vannucchi
Journal: Blood (2010)
The Nature of the Antigen Determines Leukemia Development and Behavior in the Eμ-TCL1 Transgenic Mouse Model of CLL
Authors: Sara Bennardo, Stefano Iacovelli, Stefania Gobessi, Mirza Suljagic, Daniel Bilbao, Julia Eckl-Dorna, Hongsheng Wang, Richard J. Cornall, Stephen H Clarke, Carlo M. Croce, Dimitar G Efremov
Journal: Blood (2012)
Oxidation Of Peroxiredoxins By Thioredoxin Inactivation Is Mediated In Arsenic Trioxide-Induced Reactive Oxygen Species Formation and Its Cytotoxicity In Acute Promyelocytic Leukemia Cells
Authors: Yeung-Chul Mun, Jee-Young Ahn, Eun-Sun Yoo, Jungwon Huh, Kyoung Eun Lee, Eunmi Nam, Soon Nam Lee, Chu-Myong Seong
Journal: Blood (2013)
BRAFV600E Induces ABCB1/P-Glycoprotein Expression and Drug Resistance in B-Cells Via AP-1 Activation
Authors: Yo-Ting Tsai, Gerard Lozanski, Amy M. Lehman, Ellen Sass, Erin K. Hertlein, Santosh Salunke, Ching-Shih Chen, Michael R. Grever, John C. Byrd, David M. Lucas
Journal: Blood (2015)
Standard of Care of Patients with CML Treated in Community Based Oncology Group Practices in Rhineland-Palatinate (Germany)
Authors: Rudolf Weide, Bernhard Rendenbach, Monika Grundheber, Oswald Burkhard, Joachim Behringer, Michael Maasberg, Peter Ehscheidt, John Werner Strehl, Richard Hansen, Stefan Feiten
Journal: Blood (2016)
SCIDOT-19. A MECHANICALLY-ENGINEERED SPRAY TO INCREASE BRAIN PENETRATION OF CHEMOTHERAPEUTIC NANOPARTICLES IN THE TREATMENT OF HIGH-GRADE GLIOMAS
Authors: Phoebe McCrorie, Vincenzo Taresco, Zeyuan Xu, Alison Ritchie, Philip A Clarke, Maria Marlow, Ruman Rahman
Journal: Neuro-Oncology (2019)

Abstract Design and implementation of innovative local drug delivery systems (DDS) may overcome current limitations in GBM treatment, such as the lack of therapeutic drug concentrations reaching residual GBM cells following surgery. Here we describe a novel DDS which utilises a bespoke mechanically engineered spray device, designed for safe surgical use, to deliver a mucoadhesive hydrogel containing chemotherapeutic nanoparticles (NPs) into the tumour resection margins. The overall aim is to spray a NP and polymer solution onto the resection cavity and potentially increase penetration of anti-cancer drugs within the 2 cm reoccurrence zone beyond the infiltrative margin. The mucoadhesive gel of choice, pectin, is currently used in other in vivo applications; however we have repurposed this for the brain. Pectin is biocompatible with GBM and human astrocyte cells in vitro and showed neither toxicity nor inflammation for up to 2 weeks upon orthotopic brain injection. Pectin is biodegradable in artificial CSF and is capable of being sprayed from the engineered device. A panel of polymeric, oil-based and polymer-coated NPs have been developed and optimised to maximise drug encapsulation of etoposide and olaparib as proof-of-concept for combination drug delivery. Etoposide/olaparib was chosen due to cytotoxicity from 5 GBM cell lines, including primary lines isolated from the invasive tumour margin (Mean IC50 of 1.1 µM and 8.3 µM respectively). The optimal NP/drug formulation (based on drug encapsulation, spray capability and bio-adhesiveness) will ultimately be assessed for tolerability and efficacy using orthotopic allograft and xenograft high-grade glioma models, including measurement of penetration of drug/nanoparticle in ex vivo murine and porcine brain using novel hybrid time-of-flight/Orbitrap TM secondary ion mass spectrometer (orbiSIMS) technology.
They call us fellows: the challenge of gender bias in the Australasian College of Sport and Exercise Physicians
Authors: Louise Tulloh
Journal: British Journal of Sports Medicine (2019)

Last year, BJSM published the editorial ‘We need to talk about manels’1 as a foray into implicit gender discrimination within Sport and Exercise Medicine (SEM). In this editorial, I seek to outline the situation for women within the Australasian College of Sport and Exercise Physicians (ACSEP) and its challenges in overcoming gender imbalance.

The ACSEP has the proud reputation of developing one of the world’s first structured SEM specialist training programme and paving the way for doctors to choose SEM as a valid and recognised vocation. But it is largely a male organisation. Notably, I am the 16th president, and the first woman in that role, in a college that is 36 years old. Our 2019 gender dashboard reveals 23% of fellows, 30% of registrars and only 28% of training programme applicants are women (figure 1).



Figure 1 
ACSEP Gender Dashboard 2019



The numbers of women applying to train with ACSEP are not at parity. Furthermore, these numbers have plateaued. As a result of such disappointing figures, we are taking deliberate action towards gender parity. If we are to serve our …
Effects of Granulocyte Colony Stimulating Factor (G-CSF) On Monosomy 7 Aneuploidy and T Cell Subsets in Healthy Donors.
Authors: Matthew J. Olnes, Susan Leitman, Angelique Biancotto, J. Philip McCoy, Susan Miranda, Zachary Tucker, Loretta Pfannes, Megan Furnari, Neal S Young, Elaine M Sloand
Journal: Blood (2009)
Safety of Liposomal Cytarabine (DepoCyte®) in the Central Nervous System (CNS) Prophylaxis of Patients with Non-Hodgkin’s Lymphoma (NHL) and Acute Lymphoblastic Leukaemia: Results of a Single-Centre Experience
Authors: Fabio Ardizzone, Luciano Vitali, Michele Sciacca, Paola Migliora, Cristina Ravanelli, Alberto Santagostino
Journal: Blood (2008)
US hospital is accused of keeping vegetative patient alive to boost its transplant survival rate
Authors: Owen Dyer
Journal: BMJ (2019)

Federal agents are investigating a New Jersey hospital accused of keeping a patient with catastrophic brain damage alive for a year and barely consulting his family, in order to keep its one year transplantation survival rate from falling to a level where the programme’s Medicare certification might be withdrawn.

The Centers for Medicare and Medicaid Services, which has its own law enforcement agency, will lead the investigation into Newark Beth Israel Medical Center. The hospital has launched its own internal probe.

The allegations were raised by public interest watchdog ProPublica, which says it has recordings of meetings at which Beth Israel doctors discussed the fate of patient Darryl Young. Young, who is 61 years old, has been in a vegetative state since receiving a new heart on 21 September 2018, …
Timely Controlled T Cell Receptor Expression of Genetically Engineered Precursor T Cells Requires Early Transgene Induction for Leukemia Control after Hematopoietic Stem Cell Transplantation
Authors: Sayed Shahabuddin Hoseini, Martin Hapke, Jessica Herbst, Dirk Wedekind, Rolf Baumann, Andreas Krueger, Niels Heinz, Bernhard Schiedlmeier, Dario Vignali, Marcel R.M. van den Brink, Axel Schambach, Bruce R. Blazar, Martin G. Sauer
Journal: Blood (2014)
Clinical Reflection of Immunophenotyping in Paroxysmal Nocturnal Hemoglobinuria: Experience of a Single Center
Authors: Ugur Sahin, Mustafa Merter, Pinar Ataca, Erden Atilla, Berna Atesagaoglu, Gultekin Pekcan, Sinem Civriz Bozdag, Selami Kocak Toprak, Pervin Topcuoglu, Onder Arslan, Muhit Ozcan, Taner Demirer, Osman Ilhan, Hamdi Akan, Meral Beksac, Nahide Konuk, Gunhan Gurman
Journal: Blood (2014)
Characteristics of Patients Presenting with Secondary Myelodysplastic Syndrome During Treatment with Lenalidomide for Relapsed/Refractory Multiple Myeloma: 5q Deletions Can Be Observed
Authors: Rashmi S. Goswami, David Barth, Esther Masih-Khan, Haowei (Linda) Sun, Manoj Mathew, Christine Chen, Suzanne Trudel, Suzanne Kamel-Reid, Donna E. Reece
Journal: Blood (2010)
Non Homologous End Joining, a Marker Of Genomic Instability Is Elevated In Multiple Myeloma: A New Prognostic Factor
Authors: Teresa Calimeri, Mehmet Kemal Samur, Nicola Amodio, Michele Cea, Antonia Cagnetta, Mariateresa Fulciniti, Sophia Adamia, Marco Rossi, Yu-Tzu Tai, Fortunato Morabito, Abdel Kareem Azab, Stephane Minvielle, Herve Avet-Loiseau, Cheng Li, Jean-Bernard Lazaro, Kenneth C. Anderson, Masood A. Shammas, Pierfrancesco Tassone, Nikhil C. Munshi
Journal: Blood (2013)
Pexidartinib: First Approval
Authors: Yvette N. Lamb
Journal: Drugs (2019)

Pexidartinib (TURALIO™) is an orally administered small molecule tyrosine kinase inhibitor with selective activity against the colony-stimulating factor 1 (CSF1) receptor, KIT proto-oncogene receptor tyrosine kinase (KIT) and FMS-like tyrosine kinase 3 harboring an internal tandem duplication mutation (FLT3-ITD). In August 2019, the US FDA approved pexidartinib capsules for the treatment of adult patients with symptomatic tenosynovial giant cell tumor (TGCT) associated with severe morbidity or functional limitations and not amenable to improvement with surgery. This approval was based on positive results from the phase III ENLIVEN trial. Pexidartinib is being investigated in various malignancies as monotherapy or combination therapy. This article summarizes the milestones in the development of pexidartinib leading to its first approval for TGCT.
Cardiac resynchronisation therapy in heart failure patients with ischaemic vs non-ischaemic aetiology : results from 11088 patients in the ESC CRT Survey II
Authors: C. Camilla Normand, C. Linde, A. Auricchio, N. Bogale, J. Cleland, A. Gitt, C. Stellbrink, S. Anker, G. Filippatos, M. Gasparini, G. Hindricks, Carina Blomström-Lundqvist, P. Ponikowski, F. Ruschitzka, K. Dickstein
Journal: European Journal of Heart Failure (2018)
Evaluation of Idelalisib with B-Cell Receptor or Orthogonal Pathway Inhibitors in Diffuse Large B-Cell Lymphoma Cell Lines in Vitro and In Vivo
Authors: Sarah Meadows, Anella Yahiaoui, Rick Sorensen, Zhi-Hua Cui, Robert Brockett, Kathleen S Keegan, Stacey Tannheimer
Journal: Blood (2016)
Fluorescence Activated Cell Sorting (FACS) Followed by Fluorescence In Situ Hybridization (FISH) To Determine Clonal Origins of Cells in Myelodysplastic Syndrome (MDS) with Paroxysmal Nocturnal Hemoglobinuria (PNH).
Authors: Minoo Battiwalla, Sheila Sait, AnneMarie W. Block, Ibrahim Kebbewar, Manmeet S. Ahluwalia, Earl A. Timm, Paul K. Wallace
Journal: Blood (2007)
The Investigational Aurora A Kinase Inhibitor MLN8237 in Combination with Vincristine Demonstrates Robust Anti-Tumor Activity in Preclinical B-Cell Non-Hodgkin's Lymphoma Models
Authors: Mengkun Zhang, Jessica Huck, Marc Hyer, Karuppian Kannan, Wen Chyi Shyu, Susan Chen, Mark Manfredi, Jeffrey Ecsedy
Journal: Blood (2011)
Stable Polyclonal Murine Long-Term Hematopoiesis without Clonal Exhaustion of MGMT P140K Expressing Murine Hematopoietic Stem Cells after Extended Reduced Intensity Selection.
Authors: Claudia R. Ball, Manfred Schmidt, Ingo H. Pilz, Fessler Sylvia, David A. Williams, Christof von Kalle, Hanno Glimm
Journal: Blood (2006)
Update on phase II trial of cetuximab plus S-1/oxaliplatin (SOX) for metastatic colorectal cancer (mCRC): JACCRO CC-06
Authors: Yu Sunakawa, Wataru Ichikawa, Ken Hagiwara, Masahiro Tsuda, Akinori Takagane, Hisateru Yasui, Hironaga Satake, Tadamichi Denda, Yoshihiko Segawa, Hiroaki Tanioka, Masahito Kotaka, Mitsugu Kochi, Takanori Watanabe, Masato Nakamura, Akihito Tsuji, Satoshi Tani, Yuji Negoro, Kazutoshi Tobimatsu, Masahiro Takeuchi, Masashi Fujii
Journal: Annals of Oncology (2019)
A Multicenter Study of a Gemcitabine-Based Regimen in Relapsed or Refractory Hodgkin’s Lymphoma Patients.
Authors: Patricia Validire, Christophe Fermé, Pauline Brice, Marine Diviné, Jean Gabarre, Krimo Bouabdallah, Olivier Fitoussi, Driss Chaoui, Hélène Pacquement, Carole Soussain, Patrice Carde, Rafika Sahli, Didier Decaudin
Journal: Blood (2007)
Prognostic Factors in Patients with HIV-Associated Hodgkin Lymphoma: An Analysis of 199 Cases
Authors: Michael Furman, Jeremy S. Abramson, Brady E Beltran, Michele Bibas, Mark Bower, Jaime Collins, Joseph M. Connors, Kate Cwynarski, Minh-Li Nguyen, Josep-Maria Ribera, Paula Y Tanaka, Julie M Vose, Jorge J Castillo
Journal: Blood (2012)
MetaCell: analysis of single-cell RNA-seq data using K-nn graph partitions
Authors: Yael Baran, Akhiad Bercovich, Arnau Sebe-Pedros, Yaniv Lubling, Amir Giladi, Elad Chomsky, Zohar Meir, Michael Hoichman, Aviezer Lifshitz, Amos Tanay
Journal: Genome biology (2019)

scRNA-seq profiles each represent a highly partial sample of mRNA molecules from a unique cell that can never be resampled, and robust analysis must separate the sampling effect from biological variance. We describe a methodology for partitioning scRNA-seq datasets into metacells: disjoint and homogenous groups of profiles that could have been resampled from the same cell. Unlike clustering analysis, our algorithm specializes at obtaining granular as opposed to maximal groups. We show how to use metacells as building blocks for complex quantitative transcriptional maps while avoiding data smoothing. Our algorithms are implemented in the MetaCell R/C++ software package.
The VEINES-QOL/Sym Questionnaire Is a Valid and Reliable Measure of Quality of Life in Patients with Deep Venous Thrombosis.
Authors: Susan R. Kahn, Donna L. Lamping, Thierry Ducruet, Louise Arsenault, Marie Jose Miron, Andre Roussin, Sylvie Desmarais, France Joyal, Jeannine Kassis, Susan Solymoss, Louis Desjardins
Journal: Blood (2004)
A community-based transcriptomics classification and nomenclature of neocortical cell types
Authors: Rafael Yuste, Michael Hawrylycz, Nadia Aalling, Argel Aguilar-Valles, Detlev Arendt, Ruben Armañanzas, Giorgio A. Ascoli, Concha Bielza, Vahid Bokharaie, Tobias Borgtoft Bergmann, Irina Bystron, Marco Capogna, YoonJeung Chang, Ann Clemens, Christiaan P. J. de Kock, Javier DeFelipe, Sandra Esmeralda Dos Santos, Keagan Dunville, Dirk Feldmeyer, Richárd Fiáth, Gordon James Fishell, Angelica Foggetti, Xuefan Gao, Parviz Ghaderi, Natalia A. Goriounova, Onur Güntürkün, Kenta Hagihara, Vanessa Jane Hall, Moritz Helmstaedter, Suzana Herculano-Houzel, Markus M. Hilscher, Hajime Hirase, Jens Hjerling-Leffler, Rebecca Hodge, Josh Huang, Rafiq Huda, Konstantin Khodosevich, Ole Kiehn, Henner Koch, Eric S. Kuebler, Malte Kühnemund, Pedro Larrañaga, Boudewijn Lelieveldt, Emma Louise Louth, Jan H. Lui, Huibert D. Mansvelder, Oscar Marin, Julio Martinez-Trujillo, Homeira Moradi Chameh, Alok Nath Mohapatra, Hermany Munguba, Maiken Nedergaard, Pavel Němec, Netanel Ofer, Ulrich Gottfried Pfisterer, Samuel Pontes, William Redmond, Jean Rossier, Joshua R. Sanes, Richard H. Scheuermann, Esther Serrano-Saiz, Jochen F. Staiger, Peter Somogyi, Gábor Tamás, Andreas Savas Tolias, Maria Antonietta Tosches, Miguel Turrero García, Christian Wozny, Thomas V. Wuttke, Yong Liu, Juan Yuan, Hongkui Zeng, Ed Lein
Journal: Nature Neuroscience (2020)

To understand the function of cortical circuits, it is necessary to catalog their cellular diversity. Past attempts to do so using anatomical, physiological or molecular features of cortical cells have not resulted in a unified taxonomy of neuronal or glial cell types, partly due to limited data. Single-cell transcriptomics is enabling, for the first time, systematic high-throughput measurements of cortical cells and generation of datasets that hold the promise of being complete, accurate and permanent. Statistical analyses of these data reveal clusters that often correspond to cell types previously defined by morphological or physiological criteria and that appear conserved across cortical areas and species. To capitalize on these new methods, we propose the adoption of a transcriptome-based taxonomy of cell types for mammalian neocortex. This classification should be hierarchical and use a standardized nomenclature. It should be based on a probabilistic definition of a cell type and incorporate data from different approaches, developmental stages and species. A community-based classification and data aggregation model, such as a knowledge graph, could provide a common foundation for the study of cortical circuits. This community-based classification, nomenclature and data aggregation could serve as an example for cell type atlases in other parts of the body.
Whole Genome and Transcriptome Analysis of Waldenstrom's Cell Lines Show Preservation of Many Important Genomic Features of Primary Disease, and Identify a Non-L265P Mutation in MYD88
Authors: Zachary Hunter, Yang Cao, Guang Yang, Xia Liu, Jie Chen, Lian Xu, Nicholas Tsakmaklis, Jiaji Chen, Christopher J Patterson, Jorge J Castillo, Steven P Treon
Journal: Blood (2015)
SIRT1, a Longevity Gene Encoded Protein, Regulates Apoptosis of Adult T-Cell Leukemia Cells and Its Inhibition by Sirtinol Induces Apoptosis.
Authors: Tomohiro Kozako, Teruhisa Shoji, Akiyoshi Aikawa, Satoru Hayashida, Yukako Kuramoto, Rie Mononagare, Shinichiro Honda, Hiroshi Shimeno, Shinji Soeda, Makoto Yoshimitsu, Yohann White, Naomichi Arima
Journal: Blood (2009)
Clinical Impact Of Dose Modification On Response To Ponatinib In Patients With Chronic Phase Chronic Myeloid Leukemia (CP-CML)
Authors: Javier Pinilla-Ibarz, Jorge E. Cortes, Dong-Wook Kim, Philipp D. Le Coutre, Ronald Paquette, Charles Chuah, Franck E. Nicolini, Jane F Apperley, H. Jean Khoury, John F. Dipersio, Daniel J DeAngelo, Elisabetta Abruzzese, Delphine Rea, Michele Baccarani, Martin C Muller, Carlo Gambacorti-Passerini, Stephanie Lustgarten, Victor M. Rivera, Tim Clackson, Christopher D Turner, Frank G Haluska, Francois Guilhot, Michael W. Deininger, Andreas Hochhaus, Timothy P. Hughes, John M Goldman, Neil P. Shah, Hagop M. Kantarjian, Moshe Talpaz
Journal: Blood (2013)