Diagnosis of Pulmonary Embolism During Pregnancy
Authors: Marc Righini, Grégoire Le Gal
Journal: Annals of Internal Medicine (2019)

Letters16 July 2019Diagnosis of Pulmonary Embolism During PregnancyMarc Righini, MD and Grégoire Le Gal, MD, PhDMarc Righini, MDGeneva University Hospitals, Geneva, Switzerland (M.R.)Search for more papers by this author and Grégoire Le Gal, MD, PhDOttawa University Hospital, Ottawa, Ontario, Canada (G.L.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L19-0192 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Our trial is the first prospective management outcome study on PE in pregnant patients. In contrast, the DiPEP study was a retrospective analysis of 2 cohorts (one of women with suspected PE recruited in 11 centers and one of women with confirmed PE across the United Kingdom) and included pregnant and postpartum women. The DiPEP study used different D-dimer assays with different thresholds (1). It did not specify the timing of D-dimer measurement, but most women were already receiving anticoagulant therapy at the time of testing. Also, the final comparator to assess the diagnostic performance of this testing ...References1. Hunt BJ, Parmar K, Horspool K, et al; DiPEP research group. The DiPEP (Diagnosis of PE in Pregnancy) biomarker study: an observational cohort study augmented with additional cases to determine the diagnostic utility of biomarkers for suspected venous thromboembolism during pregnancy and puerperium. Br J Haematol. 2018;180:694-704. [PMID: 29359796] doi:10.1111/bjh.15102 CrossrefMedlineGoogle Scholar2. Chan WS, Chunilal S, Lee A, et al. A red blood cell agglutination D-dimer test to exclude deep venous thrombosis in pregnancy. Ann Intern Med. 2007;147:165-70. [PMID: 17679704] LinkGoogle Scholar3. Zhou M, Hu Y, Long X, et al. Diagnostic performance of magnetic resonance imaging for acute pulmonary embolism: a systematic review and meta-analysis. J Thromb Haemost. 2015;13:1623-34. [PMID: 26179627] doi:10.1111/jth.13054 CrossrefMedlineGoogle Scholar4. Stein PD, Chenevert TL, Fowler SE, et al; PIOPED III (Prospective Investigation of Pulmonary Embolism Diagnosis III) Investigators. Gadolinium-enhanced magnetic resonance angiography for pulmonary embolism: a multicenter prospective study (PIOPED III). Ann Intern Med. 2010;152:434-43. [PMID: 20368649]. doi:10.7326/0003-4819-152-7-201004060-00008 LinkGoogle Scholar5. Revel MP, Sanchez O, Couchon S, et al. Diagnostic accuracy of magnetic resonance imaging for an acute pulmonary embolism: results of the ‘IRM-EP' study. J Thromb Haemost. 2012;10:743-50. [PMID: 22321816] doi:10.1111/j.1538-7836.2012.04652.x CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Geneva University Hospitals, Geneva, Switzerland (M.R.)Ottawa University Hospital, Ottawa, Ontario, Canada (G.L.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M18-1670. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDiagnosis of Pulmonary Embolism During Pregnancy Marc Righini , Helia Robert-Ebadi , Antoine Elias , Olivier Sanchez , Emmanuelle Le Moigne , Jeannot Schmidt , Catherine Le Gall , Jacques Cornuz , Drahomir Aujesky , Pierre-Marie Roy , Céline Chauleur , Olivier T. Rutschmann , Pierre-Alexandre Poletti , Grégoire Le Gal , and Diagnosis of Pulmonary Embolism During Pregnancy Steve Goodacre , Beverley Hunt , and Catherine Nelson-Piercy Diagnosis of Pulmonary Embolism During Pregnancy Stephen Malnick and Lucy Kikayon Metrics 16 July 2019Volume 171, Issue 2Page: 148KeywordsAngiographyCohort studiesD-dimerDisclosurePregnancyProspective studiesSafetySafety studiesTreatment guidelinesVenous thromboembolism ePublished: 16 July 2019 Issue Published: 16 July 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...