tbuckley/cabot-search huggingface dataset:
Abstract 13224: Which White Cell Subtypes Predict the Presence of Coronary Artery Disease in High Risk Patients Over 55 Years Old?
Authors: Issada Trakarnwijitr, Bobby V Li, Heath Adams, Jamie Layland, John Garlick, Andrew M Wilson
Journal: Circulation (2015)

Introduction: Inflammation has an important role in initiation and progression of coronary artery disease (CAD). Different white cell count (WCC) subtypes may reflect different mechanisms of this complex disease, and may be valuable clinically in risk stratification and detection of patients with CAD. Studies on the correlation between WCC subtypes and CAD have yielded conflicting results. Hypothesis: We hypothesized that WCC subtypes are associated with the presence of CAD in high-risk patients over 55 years old. Methods: We analyzed 622 patients over the age of 55 from the BRAVEHEART and MINACS cohort who were referred for coronary angiogram at our institution. Univariate and multivariate logistic regression models were used to compare different WCC subtypes as predictors of presence of CAD, defined as ≥50% stenosis of 1 or more coronary arteries. We adjusted for age, sex and conventional cardiac risk factors. Results: On univariate analysis, patients with CAD had significantly more CVD risk factors compared to control patients. Markers associated with CAD were lower lymphocytes (tertile 2 OR 0.61, 95% CI 0.39-0.98, p=0.040, tertile 3 OR 0.70, 95% CI 0.44-1.12, p=0.139), and higher monocytes (tertile 3 OR 2.51, 95% CI 1.45-4.34, p=0.001), neutrophil-lymphocyte ratio (NLR) (OR 1.70, 95% CI 1.07-2.68, p=0.024), and monocyte-lymphocyte ratio (MLR) (tertile 3 OR 2.62, 95% CI 1.61-4.26, p&lt;0.001). After adjustment for CVD risk factors, lower lymphocytes (tertile 2 OR 0.40, 95% CI 0.22-0.73, p=0.003, tertile 3 OR 0.50, 95% CI 0.27-0.93, p=0.028), and higher monocytes (tertile 3 OR 2.38, 95% CI 1.23-4.61, p=0.010), NLR (tertile 3 OR 1.91, 95% CI 1.08-3.38, p=0.025), and MLR (tertile 3 OR 2.26, 95% CI 1.23-4.14, p=0.009) were associated with CAD. Conclusions: In high-risk patients over 55 years old, lower lymphocytes, and higher monocytes, NLR and MLR were associated with angiographically determined CAD independent of other risk factors. Monocytes and MLR were the strongest correlates of CAD in high-risk patients over 55. Whether these can be used as biomarkers of CAD in high risk patients warrants further study.
New short regimens for latent tuberculosis treatment: safety first!
Authors: Dick Menzies, Anete Trajman
Journal: European Respiratory Journal (2018)

<b>Safety must be the first consideration in evaluating any new regimen for latent tuberculosis treatment. Caution is needed when using isoniazid plus rifapentine, once or twice weekly, in individuals aged over 50 years, even for a short period.</b>http://ow.ly/T0fT30mOs7m
Cytokine Gene Polymorphisms Are Associated with Disease Response to Blinatumomab in Patients with B-Cell Acute Lymphoblastic Leukemia
Authors: Nikeshan Jeyakumar, Ibrahim Aldoss, Dongyun Yang, Sally Mokhtari, Ketevan Gendzekhadze, Margaret O'Donnell, Joycelynne Palmer, Joo Y Song, Guido Marcucci, Anthony S. Stein, Stephen J Forman, Vinod A. Pullarkat, Xiwei Wu, Ryotaro Nakamura
Journal: Blood (2018)
Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia
Authors: Piers Blombery, Mary Ann Anderson, Jianan Gong, Rachel Thijssen, Richard W Birkinshaw, Ella Thompson, Charis E Teh, Tamia Nguyen, Zhen Xu, Christoffer Flensburg, Thomas Lew, Ian Majewski, Daniel Gray, David Alan Westerman, Constantine S. Tam, John F. Seymour, Peter E Czabotar, David Huang, Andrew W. Roberts
Journal: Blood (2018)
Abstract 16617: Association of Inflammation in Epicardial Adipose Tissue as Assessed by 16-Fluorodeoxyglucose Positron Emission Tomography With Coronary Artery Disease
Authors: Manu Kaushik, Scott Degenhardt, Venkata M Alla, Atul Ramachandran, Jyoti Ramachandran, Michael Del Core, Devendra K Agrawal, Syed M Mohiuddin, Samuel Mehr, Subhash Paknikar
Journal: Circulation (2013)

Background: Extent of epicardial adipose tissue (EAT) has been shown to be associated with coronary artery disease (CAD). 16-Flourodeoxyglucose(FDG) uptake on positron emission tomography(PET) can ...
Abstract 15204: The Effect of Primary Prevention Statin Therapy on Mortality in Persons With Aortic Atherosclerosis
Authors: Rabia R Razi, Somjot S Brar, Michael B Jorgensen, Ian Finn, Daniel Zisook
Journal: Circulation (2016)

Introduction: The prevalence of aortic atherosclerosis has increased as a result of greater availability and use of medical imaging. The role of statin therapy in subjects with aortic atheroscleros...
Abstract 17356: Anti-arrhythmic Effect of Exosomes Secreted by Cardiosphere-derived Cells: Reduction in Inducible Ventricular Arrhythmias in a Porcine Model of Chronic Myocardial Infarction
Authors: James F Dawkins, Romain Gallet De Saint, Jackelyn Valle, Eugenio Cingolani, Eduardo Marban
Journal: Circulation (2015)

Introduction: Myocardial infarction (MI) survivors are at increased risk for ventricular arrhythmias and sudden death; risk directly correlates with infarct size and scar heterogeneity. The regenerative effects of cardiosphere-derived cells (CDCs),which are now in phase 2 clinical trials, are mediated by exosomes (CDC exo ).Like CDCs, CDC exo reduce scar size and increase viable mass in chronic MI. These naturally secreted nanoparticles mediate cell-cell signaling by transfer of bioactive payloads including microRNAs. Hypothesis: We hypothesized that post-MI hearts treated with CDC exo exhibit reduced inducibility of ventricular tachycardia (VT). Methods: An angioplasty balloon was inflated in the left anterior descending coronary artery for 150 minutes followed by one month of reperfusion in 7 female Yucatán minipigs. Electroanatomical mapping (EAM) was then performed to define the MI border zone (4.1-7mV NOGA tip potentials), after which we injected either CDC exo (7.5mg/1 ml n=4) or phosphate-buffered saline(PBS, 1ml, n=3), in 12-15 border zone sites via MYOSTAR catheter. Four weeks later, EAM was repeated and arrhythmia susceptibility was probed using both programmed ventricular stimulation and burst pacing (train of 8 beats from 400 to 200ms in 10 ms decrements) at the infarct border zone, and in healthy tissue near the posterolateral wall (&gt;10mv). Arrhythmia morphology was characterized by 12 lead ECG. Final infarct size was quantified by histology (TTC). Results: In CDC exo -injected pigs, infarct size was lower (11.4% vs 7.8%, p=0.05) and viable mass was higher (69.3g vs 79.3g, p=0.03) than in PBS controls. No sustained VT was induced by programmed ventricular stimulation. Burst pacing elicited VT which rapidly degenerated into ventricular fibrillation in all control animals (n=3), but in only 1 of 4 CDC exo -treated animals (p=0.04),when paced at both the infarct border and healthy myocardium. Conclusions: Exosomes from CDCs regenerate myocardium post-MI. Pigs treated with CDC exo exhibit reduced inducibility of sustained ventricular arrhythmias by burst pacing. This first demonstration of an anti-arrhythmic effect of exosomes motivates more extensive investigation of the effects of these nanoparticles on rhythm disorders.
Abstract 11149: Efficacy of Statin Therapy for Inducing Coronary Plaque Regression in Patient With Low Cholesterol Level
Authors: Kohei Wakabayashi, Tsuyoshi Nozue, Shingo Yamamoto, Shinichi Tohyama, Kazuki Fukui, Shigeo Umezawa, Yuko Onishi, Tomoyuki Kunishima, Akira Sato, Shogo Miyake, Yoshihiro Morino, Takao Yamauchi, Kiyoshi Hibi, Toshiya Muramatsu, Takashi Sozu, Mitsuyasu Terashma, Hiroshi Suzuki, Ichiro Michishita
Journal: Circulation (2014)

Introduction: Statin therapy induces coronary plaque regression and cardiovascular events; however, the efficacy for the patients with low serum cholesterol level is still controversial. The present study was therefore conducted to assess the relationship between serum cholesterol level at baseline and coronary plaque regression by statin therapy, using serial intravascular ultrasound (IVUS) data from the TRUTH (treatment with statin on atheroma regression evaluated by IVUS with virtual histology) study. Hypothesis: Statin therapy may not induce coronary plaque regression in patient with low cholesterol level at baseline. Methods: The TRUTH study evaluated the effects of 8-month statin therapy on coronary atherosclerosis in 164 patients. All patients were statin naive and were started statin therapy after enrollment. The primary end point of the present study was % coronary plaque volume change in IVUS. Results: Serial IVUS data, baseline and 8-month follow-up, was available for 119 patients. The patients...
Abstract 18461: Catheter Directed Thrombolysis versus Systemic Thrombolysis for the Treatment of Pulmonary Embolism
Authors: Bram J Geller, Srinath Adusumalli, Lin Yang, Peter W Groeneveld, Jay Giri
Journal: Circulation (2017)

Introduction: Catheter-directed thrombolysis (CDT) and systemic thrombolysis (ST) are used to treat intermediate/high-risk pulmonary embolism (PE) in the absence of comparative safety and effective...
Erratum: Corrigendum: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
Authors: Helen R Warren, Evangelos Evangelou, Claudia P Cabrera, He Gao, Meixia Ren, Borbala Mifsud, Ioanna Ntalla, Praveen Surendran, Chunyu Liu, James P Cook, Aldi T Kraja, Fotios Drenos, Marie Loh, Niek Verweij, Jonathan Marten, Ibrahim Karaman, Marcelo P Segura Lepe, Paul F O'Reilly, Joanne Knight, Harold Snieder, Norihiro Kato, Jiang He, E Shyong Tai, M Abdullah Said, David Porteous, Maris Alver, Neil Poulter, Martin Farrall, Ron T Gansevoort, Sandosh Padmanabhan, Reedik Mägi, Alice Stanton, John Connell, Stephan J L Bakker, Andres Metspalu, Denis C Shields, Simon Thom, Morris Brown, Peter Sever, Tõnu Esko, Caroline Hayward, Pim van der Harst, Danish Saleheen, Rajiv Chowdhury, John C Chambers, Daniel I Chasman, Aravinda Chakravarti, Christopher Newton-Cheh, Cecilia M Lindgren, Daniel Levy, Jaspal S Kooner, Bernard Keavney, Maciej Tomaszewski, Nilesh J Samani, Joanna M M Howson, Martin D Tobin, Patricia B Munroe, Georg B Ehret, Louise V Wain, Michael R Barnes, Ioanna Tzoulaki, Mark J Caulfield, Paul Elliott
Journal: Nature Genetics (2017)
Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis
Authors: João Pedro Garcia, Jeroen Stein, Yunpeng Cai, Frank Riemers, Ezequiel Wexselblatt, Jesper Wengel, Marianna Tryfonidou, Avner Yayon, Kenneth A. Howard, Laura B. Creemers
Journal: Journal of Controlled Release (2018)

To date no disease-modifying drugs for osteoarthritis (OA) are available, with treatment limited to the use of pain killers and prosthetic replacement. The ADAMTS (A Disintegrin and Metallo Proteinase with Thrombospondin Motifs) enzyme family is thought to be instrumental in the loss of proteoglycans during cartilage degeneration in OA, and their inhibition was shown to reverse osteoarthritic cartilage degeneration. Locked Nucleic Acid (LNA)-modified antisense oligonucleotides (gapmers) released from biomaterial scaffolds for specific and prolonged ADAMTS inhibition in co-delivered and resident chondrocytes, is an attractive therapeutic strategy. Here, a gapmer sequence identified from a gapmer screen showed 90% ADAMTS5 silencing in a monolayer culture of human OA chondrocytes. Incorporation of the gapmer in a fibrin-hyaluronic acid hydrogel exhibited a sustained release profile up to 14 days. Gapmers loaded in hydrogels were able to transfect both co-embedded chondrocytes and chondrocytes in a neighboring gapmer-free hydrogel, as demonstrated by flow cytometry and confocal microscopy. Efficient knockdown of ADAMTS5 was shown up to 14 days in both cell populations, i.e. the gapmer-loaded and gapmer-free hydrogel. This work demonstrates the use applicability of a hydrogel as a platform for combined local delivery of chondrocytes and an ADAMTS-targeting gapmer for catabolic gene modulation in OA.
Digital Media Use and ADHD Symptoms
Authors: Margaret H. Sibley, Stefany J. Coxe
Journal: JAMA (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Safety and Efficacy of Evomela™ in Myeloma Autotransplants
Authors: Kimberly Amelsberg, Nisha Joseph, Amelia Langston, Jonathan L Kaufman, Craig C Hofmeister, Edmund K. Waller, Michael Graiser, Robin Larocco, Leonard Heffner, Madhav V Dhodapkar, Sagar Lonial, Ajay K Nooka
Journal: Blood (2018)
Naevoid acanthosis nigricans or RAVEN (rounded and velvety epidermal naevus) and mosaic <i>FGFR3</i> and <i>FGFR2</i> mutations
Authors: D. Bessis, A. Petit, M. Battistella, E. Bourrat, C. Girard, V. Pallure, M. Marque, J.‐P. Lacour, A. Vitetta, É. Bieth, J. Selves, J. Solassol, J. Vendrell
Journal: British Journal of Dermatology (2018)

Linked Article:Larsabal et al. Br J Dermatol 2019; 180:201–202.
Abstract 16711: Left Atrial Abnormality is Associated With Greater Cognitive Decline Independent of Atrial Fibrillation: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS)
Authors: Lin Y Chen, Faye L Norby, Rebecca F Gottesman, Thomas H Mosley, Aaron R Folsom, Hooman Kamel, Elsayed Z Soliman, Alvaro Alonso
Journal: Circulation (2016)

Introduction: Atrial fibrillation (AF) is associated with greater cognitive decline. Abnormal P-wave terminal force in ECG lead V1 (PTFV1)—a marker of left atrial (LA) abnormality—is associated wit...
Abstract 10291: Predictive Values of N-Terminal Pro-B-Type Natriuretic Peptide and Cardiac Troponin I for Myocardial Fibrosis in Hypertrophic Obstructive Cardiomyopathy
Authors: Changlin Zhang, Rong Liu, Jiansong Yuan, Jingang Cui, Fenghuan Hu, Weixian Yang, Yan Zhang, Youzhou Chen, Shubin Qiao
Journal: Circulation (2015)

Background: Myocardial fibrosis, as a hallmark of hypertrophic cardiomyopathy (HCM), can be detected by late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR). The combination of high-sensitivity cardiac troponin T (hs-cTnT) and B-type natriuretic peptide (BNP) has been suggested useful in detecting myocardial fibrosis in patients with non-obstructive HCM. However, the values of those biomarkers to predict myocardial fibrosis in hypertrophic obstructive cardiomyopathy (HOCM) remain unclear. Hypothesis: We assessed the hypothesis that circulating levels of N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) and cardiac troponin I (cTnI) may predict LGE in patients with HOCM. Methods: Patients with HOCM (n=163; age=47.2 ± 10.8, [range 20 to 71] years; 38.7% females) underwent peripheral venous sampling to determine concentrations of NT-proBNP and cTnI. Contrast-enhanced CMR was performed to identify and quantify myocardial fibrosis. We evaluated the relation between LGE and levels of NT-pro BNP and cTnI. Results: LGE was detected in 120 of 163 patients (73.6%), and involved 31.6 ± 14.5% of left ventricle (range 2.9% to 73.5%). All participants had left ventricular outflow tract obstruction (LVOT gradient at rest, 78.7 ± 32.5 mmHg). Patients with LGE had significantly higher levels of NT-proBNP and cTnI than those without LGE (1386.2 [904.6 - 2340.8] vs. 866.6 [707.2 - 1875.2] pmol/L, P=0.003; 0.024 [0.010 - 0.049] vs. 0.010 [0.005 - 0.021] ng/ml, P&lt;0.001, respectively). The extent of LGE was positively correlated with log cTnI (r=0.371, P&lt;0.001) and log NT-proBNP (r=0.211, P=0.007). On multivariable analysis, log cTnI and log NT-proBNP were independent predictors of the presence of LGE (OR=3.916, P=0.010; OR=16.6, P=0.014, respectively). According to receiver operating characteristic curve analysis, combined measurements of NT-proBNP level ≥867.0 pmol/L and/or cTnI ≥0.025ng/ml indicated good diagnostic performance for the presence of LGE, with specificity of 92% or sensitivity of 90%. Conclusions: Both NT-proBNP and cTnI are useful for identifying myocardial fibrosis, respectively. Combined measurements of these biomarkers further improve their values in detecting myocardial fibrosis in patients with HOCM.
Abstract 15965: BAG3 Rescues Contractile Dysfunction Post-MI: Cellular Mechanism
Authors: Valerie D Myers, Feifei Su, Tijana Knezevic, Xue-Qian Zhang, Jianliang Song, Jufang Wang, Erhe Gao, Joseph Rabinowitz, Madesh Muniswamy, Joseph Y Cheung, Arthur M Feldman
Journal: Circulation (2016)

Mutations in BAG3 underlie the development of heart failure with reduced ejection fraction (HFrEF). However, little is known regarding molecular mechanisms of BAG3 in the heart. Methods: To dissect...
Abstract 16883: Liquid Chromatography-tandem Mass Spectrometry (lc-ms/ms) Demonstrates That Palmitate Can Ameliorate Cardiac Redox State Under Oxidized Conditions
Authors: Neoma T Boardman, Roy Andre Lyså, Ole-Martin Fuskevåg, Ellen Aasum
Journal: Circulation (2017)

Introduction: Changes in the ratio of reduced (GSH) to oxidized (GSSG) glutathione is commonly used to indicate redox status in the heart. However, previously reported values of myocardial GSH, GSS...
Abstract 13101: Improved Angiographic Outcomes With Delayed Stenting Compared With Immediate Stenting for Acute Myocardial Infarction. Evidence From a Meta-analysis
Authors: Ramez Nairooz, Partha Sardar, Saurav Chatterjee, Srinivas R Bapoje, Srihari S Naidu
Journal: Circulation (2014)

Introduction: High coronary thrombus burden may increase procedural complications, including distal embolization and no re-flow, during percutaneous coronary intervention for acute myocardial infar...
We Are All the Same
Authors: Mandy L. Maneval
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RGAAT: A Reference-based Genome Assembly and Annotation Tool for New Genomes and Upgrade of Known Genomes
Authors: Wanfei Liu, Shuangyang Wu, Qiang Lin, Shenghan Gao, Feng Ding, Xiaowei Zhang, Hasan Awad Aljohi, Jun Yu, Songnian Hu
Journal: Genomics Proteomics & Bioinformatics (2018)

Abstract The rapid development of high-throughput sequencing technologies has led to a dramatic decrease in the money and time required for de novo genome sequencing or genome resequencing projects, with new genome sequences constantly released every week. Among such projects, the plethora of updated genome assemblies induces the requirement of version-dependent annotation files and other compatible public dataset for downstream analysis. To handle these tasks in an efficient manner, we developed the reference-based genome assembly and annotation tool (RGAAT), a flexible toolkit for resequencing-based consensus building and annotation update. RGAAT can detect sequence variants with comparable precision, specificity, and sensitivity to GATK and with higher precision and specificity than Freebayes and SAMtools on four DNA-seq datasets tested in this study. RGAAT can also identify sequence variants based on cross-cultivar or cross-version genomic alignments. Unlike GATK and SAMtools/BCFtools, RGAAT builds the consensus sequence by taking into account the true allele frequency. Finally, RGAAT generates a coordinate conversion file between the reference and query genomes using sequence variants and supports annotation file transfer. Compared to the rapid annotation transfer tool (RATT), RGAAT displays better performance characteristics for annotation transfer between different genome assemblies, strains, and species. In addition, RGAAT can be used for genome modification, genome comparison, and coordinate conversion. RGAAT is available at https://sourceforge.net/projects/rgaat/ and https://github.com/wushyer/RGAAT_v2 at no cost.
Abstract 15533: Time to Epinephrine Administration and Survival From Out-of-hospital Cardiac Arrests Presenting With Non-shockable Rhythms
Authors: Matthew L Hansen, Rob Schmicker, Craig Newgard, Thomas D Rea, Debra Egan, Heather Herren, Brian Grunau, Franck Scheuermeyer, Sheldon Cheskes, Jamie Hutchison, Fuad Alnaji, Michael Austin, M. Riccardo Colella, Ahamed Idris, Veer Vithalani, Mohamud Daya
Journal: Circulation (2017)

Introduction: Epinephrine is used for out-of-hospital cardiac arrests (OHCA) though its efficacy is unclear. Hypothesis: Shorter time from EMS arrival to epinephrine administration is associated wi...
Race, Poverty, and Initial Implementation of Precision Medicine for Lung Cancer
Authors: Kenneth L Kehl, Christopher S Lathan, Bruce E Johnson, Deborah Schrag
Journal: JNCI Journal of the National Cancer Institute (2018)

Data are limited regarding whether the availability of biomarker-directed therapy for lung cancer exacerbates racial and socioeconomic disparities. Patients diagnosed with stage IV lung adenocarcinoma from 2008 to 2013 were identified using Surveillance, Epidemiology, and End Results Program-Medicare. The primary outcome was a Medicare claim for molecular testing within 60 days of diagnosis, analyzed using multivariable logistic regression; the secondary outcome was overall survival, analyzed using multivariable Cox proportional hazards models. All statistical tests were two-sided. Of 5556 patients, 1437 (25.9%) had molecular testing. Testing rates were 14.1% among black, 26.2% among white, and 32.8% among patients of Asian/other descent (adjusted P < .001); 20.6% among patients with Medicaid eligibility vs 28.4% among those without (adjusted P = .01); and 19.9% among patients in the highest census tract-level poverty rate quintile vs 30.7% among patients in the lowest quintile (for all quintiles, adjusted P = .18). Median survival from 60 days was 8.2 months among patients with molecular testing within 60 days of diagnosis and 6.1 months among those without (hazard ratio = 0.92, 95% confidence interval = 0.86 to 0.99; adjusted P = .02). Equitable precision medicine requires concerted implementation efforts.