AB1273 ESTABLISHMENT OF A PROSPECTIVE COHORT FOR RHEUMATOID ARTHRITIS PATIENTS WITH INTERSTITIAL LUNG DISEASE: COMPARISON OF BASELINE CHARACTERISTICS BETWEEN RHEUMATOID ARTHRITIS PATIENT WITH OR WITHOUT INTERSTITIAL LUNG DISEASE
Authors: Juyeon Kang, Hyoungyoung Kim, Ga Young Ahn, Seung-Ah Jeong, Hye Won Kim, Chan-Bum Choi, Tae-Hwan Kim, Jae-Bum Jun, Sang-Cheol Bae, Daehyun Yoo, Dong Won Park, Jang Won Sohn, Ho Joo Yoon, Su Jin Hong, Yo Won Choi, Youkyung Lee, Sang-Heon Kim, Soo-Kyung Cho, Yoon-Kyoung Sung
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background:</h3> Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) has a clinical significance of high mortality rate in patients with RA. Hence, we established a multidisciplinary prospective single center cohort for RA-ILD patients with multidisciplinary collaboration called the HUMANISM. Patients with RA who have checked a chest computed tomography (CT) scan within previous 2 years were eligible for the enrollment, and they were classified according to the presence of ILD by expert radiologists. All RA patients were assessed with various outcomes of RA, and reviewed for treatment pattern of medications annually. <h3>Objectives:</h3> To introduce a prospective, non-interventional cohort of RA-ILD patients, HUMANISM cohort and to compare baseline characteristics and treatment patterns between RA patients according to the presence of ILD using the enrollment data of this prospective cohort. <h3>Methods:</h3> We compared the baseline characteristics between RA patients with and without ILD using the Chi-square test and Student's t-test. For RA-ILD patients, we described the ILD patterns that could be identified in high-resolution CT (HRCT) to determine their dominant radiological characteristics. <h3>Results:</h3> A total of 74 RA-ILD patients and 239 RA patients without ILD were consecutively enrolled between May 2017 and October 2018. At the baseline, RA-ILD patients showed higher proportion of male patients and older age compared to RA patients without ILD. They also showed higher RF positivity than those without ILD. RA-ILD patients also have higher disease activity measured with DAS28. In the treatment, oral glucocorticoids (OC) are used in higher rate and higher doses in RA-ILD patients than those without ILD. Methotrexate (MTX) use rate was higher in RA without ILD patients compared to RA-ILD patients, but there was no difference in the prevalence of biological DMARDs. In HRCT findings of RA-ILD patients, usual interstitial pneumonia (UIP) and non-specific interstitial pneumonia (NSIP) dominant patterns were common, followed by organizing pneumonia (OP), and overlapping patterns combined with NSIP or UIP. <h3>Conclusion:</h3> We found that RA-ILD patients showed higher disease activity, male predominance and older age than those without ILD. Treatment patterns were different in the use of MTX or OCs. In our HUMANISM cohort, common HRCT findings of RA-ILD patients were UIP and NSIP. <h3>Acknowledgement:</h3> This study was funded by Bristol-Myers Squibb and JW pharmaceuticals <h3>Disclosure of Interests:</h3> Juyeon Kang: None declared, Hyoungyoung Kim: None declared, Ga Young Ahn: None declared, Seung-Ah Jeong: None declared, Hye Won Kim: None declared, Chan-Bum Choi: None declared, Tae-hwan Kim: None declared, Jae-Bum Jun: None declared, Sang-Cheol Bae: None declared, DaeHyun Yoo Grant/research support from: Celltrion, Inc., Consultant for: Celltrion, Inc., Dong Won Park: None declared, Jang Won Sohn: None declared, Ho Joo Yoon: None declared, Su Jin Hong: None declared, Yo Won Choi: None declared, Youkyung Lee: None declared, Sang-Heon Kim: None declared, Soo-Kyung Cho: None declared, Yoon-Kyoung Sung Grant/research support from: Dr. Yoon-Kyoung, Sung has received research funding from BMS, Eisai, Pfizer, JW pharmaceutical., Consultant for: Dr. Yoon-Kyoung, Sung has served as a consultant to AbbVie and Amgen, Speakers bureau: Dr. Yoon-Kyoung, Sung has received honoraria from AbbVie, Amgen, BMS, Pfizer.