tbuckley/cabot-search huggingface dataset:
ERC CLIP WITH LINE – A GERMAN PILOT SERIES
Authors: A Horn, V Meves, J Hochberger
Journal: Endoscopy (2019)

Duodenal diverticulum (DD) is a frequent condition that is described in up to 20% of endoscopically retrograde cholangiopancreatography (ERCP)1. Large DD with intradiverticular located Papilla vateri (PV) have a lower incidence2, but the exploratiuon and treatment of biliary tract (BT) can be difficult and shows significantly higher complication rates2. In 2016 the ERC Clip With Line Technique (ECLT) developed by our group as part of a method transfer from the ESD3 and was present for the first time in 2016. To visualize the PV in cases of large DD we attached dental floss via a haemoclip to the papillary roof and the line was pulled out via the mouth. Traction on the diverticular collum makes it easier to visualize/cannulate the PV.
Tumor suppression of novel anti–PD-1 antibodies mediated through CD28 costimulatory pathway
Authors: Craig Fenwick, Juan-Luis Loredo-Varela, Victor Joo, Céline Pellaton, Alex Farina, Navina Rajah, Line Esteves-Leuenberger, Thibaut Decaillon, Madeleine Suffiotti, Alessandra Noto, Khalid Ohmiti, Raphael Gottardo, Winfried Weissenhorn, Giuseppe Pantaleo
Journal: The Journal of Experimental Medicine (2019)

Classical antagonistic antibodies (Abs) targeting PD-1, such as pembrolizumab and nivolumab, act through blockade of the PD-1-PDL-1 interaction. Here, we have identified novel antagonistic anti-PD-1 Abs not blocking the PD-1-PDL-1 interaction. The nonblocking Abs recognize epitopes on PD-1 located on the opposing face of the PDL-1 interaction and overlap with a newly identified evolutionarily conserved patch. These nonblocking Abs act predominantly through the CD28 coreceptor. Importantly, a combination of blocking and nonblocking Abs synergize in the functional recovery of antigen-specific exhausted CD8 T cells. Interestingly, nonblocking anti-PD-1 Abs have equivalent antitumor activity compared with blocker Abs in two mouse tumor models, and combination therapy using both classes of Abs enhanced tumor suppression in the mouse immunogenic tumor model. The identification of the novel nonblocker anti-PD-1 Abs and their synergy with classical blocker Abs may be instrumental in potentiating immunotherapy strategies and antitumor activity.
Robert Tattersall, a Diabetes Physician Ahead of His Time
Authors: Simon R. Heller
Journal: Diabetes Care (2019)

The clinical and research landscape in the U.K. was dominated in the 1970s and 1980s by clinician scientists. Many worked as full-time employees of the National Health Service rather than universities. During a period when health services were under less pressure than today, they were able to find sufficient time to design clinical studies to answer important research questions that occurred to them while treating their patients. They also inspired a generation of junior colleagues to join their specialty and become clinical researchers themselves. In many ways it was a golden age for clinical diabetes research in Britain. Clinician scientists within the diabetes field who attained international stature include John Ward and Peter Watkins, who made major advances in diabetic neuropathy; Harry Keen, who pioneered the use of insulin pumps and introduced microalbuminuria as a sensitive test for diabetic nephropathy; and George Alberti (1), who demonstrated how low-dose insulin could be used as a practical and effective treatment for diabetic ketoacidosis. But one individual who epitomized the clinician researcher was Robert Tattersall. His contributions were many and varied and led to improved care worldwide, while the diabetes unit he developed in Nottingham came to be recognized as one of the best in the country.

Robert was born in London in July 1943, the only child of Stanley Tattersall and Edith Booth, who were psychiatrists. He was brought up in the grounds of Bucks County Mental Hospital, where his father worked in a senior administrative position. He was educated at Charterhouse School (a private boarding school) and trained in medicine at the University of Cambridge and St Thomas’ Hospital, London. After qualification he undertook his first junior post at St Thomas’ before moving to Nottingham General Hospital, where he met his future wife, Bridget Jack, while they were both doctors in …
PRMT5 is upregulated by B-cell receptor signaling and forms a positive-feedback loop with PI3K/AKT in lymphoma cells
Authors: Fen Zhu, Hui Guo, Paul D. Bates, Shanxiang Zhang, Hui Zhang, Krystle J. Nomie, Yangguang Li, Li Lu, Kaitlyn R. Seibold, Fangyu Wang, Ian Rumball, Hunter Cameron, Nguyet M. Hoang, David T. Yang, Wei Xu, Liang Zhang, Michael Wang, Christian M. Capitini, Lixin Rui
Journal: Leukemia (2019)
Pomalidomide, bortezomib, and dexamethasone for patients with relapsed or refractory multiple myeloma previously treated with lenalidomide (OPTIMISMM): a randomised, open-label, phase 3 trial
Authors: Paul G Richardson, Albert Oriol, Meral Beksac, Anna Marina Liberati, Monica Galli, Fredrik Schjesvold, Jindriska Lindsay, Katja Weisel, Darrell White, Thierry Facon, Jesus San Miguel, Kazutaka Sunami, Peter O'Gorman, Pieter Sonneveld, Pawel Robak, Sergey Semochkin, Steve Schey, Xin Yu, Thomas Doerr, Amine Bensmaine, Tsvetan Biyukov, Teresa Peluso, Mohamed Zaki, Kenneth Anderson, Meletios Dimopoulos, Niels Abildgaard, Howard Adler, Fevzi Altuntas, Olga Meltem Akay, Bipinkumar Amin, Achilleas Anagnostopoulos, Larry Anderson, Pekka Anttila, Carla Araujo, Carlos Arce-Lara, Yildiz Aydin, Supratik Basu, Ramakrishna Battini, Thaddeus Beeker, Lotfi Benboubker, Dina Ben-Yehuda, Joan Bladé, Igor Wolfgang Blau, Ralph Boccia, Lillian Burke, Peter Byeff, Nicola Cascavilla, Michele Cavo, Andrew Chantry, Yen Charles, Arvind Chaudhry, Alessandro Corso, Mark Coyne, Felipe De Arriba, Sosana Delimpasi, Pierre Desjardins, Binod Dhakal, Paolo Di Bartolomeo, Francesco Di Raimondo, Jan Dürig, Monika Engelhardt, Martine Escoffre-Barbe, Graca Esteves, Max Flogegard, Nashat Gabrail, Barbara Gamberi, Mitchell Garrison, Julie Gay, Heinz Gisslinger, Hartmut Goldschmidt, Cristina Goncalves, Laurent Gressot, Sebastian Grosicki, Wahid Hanna, Patrick Hayden, Maria Manuela Henriques Bernardo, Robert Hermann, Viran Holden, Kirsti Honkalehto, Marianne Huben, John Huffman, Hannah Hunter, Marek Hus, Madan Jagasia, Sundar Jagganath, Murali Janakiram, Ishmael Jaiyesimi, Matthew Jenner, Cristina João, Peter Johnson, Artur Jurcyszyn, Sevgi Kalayoğlu Beşişik, Suman Kambhampati, Abraham Kanate, Ihsan Karadoğan, Ali Khojasteh, Dean Kirkel, Mieczyslaw Komarnicki, Maria-Theresa Krauth, Phillip Kuriakose, Alessandra Larocca, Birgitta Lauri, Xavier Leleu, Paulo Lucio, Mario Luppi, Silvia Mangiacavalli, Clara Mariette, Kosei Matsue, Ulf-Henri Mellqvist, Larisa Mendeleeva, Michael Meshad, Carole Miller, Ann Mohrbacher, Philippe Moreau, Anna Maria Morelli, Ercan Müldür, Anthony Naassan, Hareth Nahi, Rajesh Nair, Mike O'Dwyer, Seniz Öngören Aydin, Thomas Openshaw, Timothy O'Rourke, Michael Osswald, Lindsay Overton, Asmin Pati, Michel Pavic, Brigitte Pegourie, Mustafa Pehlivan, Ana Alfonso Pierola, Torben Plesner, Andrzej Pluta, Neil Rabin, Karthik Ramasamy, Alessandro Rambaldi, Paula Rodriguez, Christoph Röllig, Jacalyn Rosenblatt, Jonathan Rosenbluth, Morten Salomo, Olga Samoylova, Jose Sastre Moral, Hamdi Sati, Carmine Selleri, Salim Shafeek, Atsushi Shinagawa, Bethany Sleckman, Clay Smith, Mehmet Sonmez, Chester Stone, Matthew Streetly, Kenshi Suzuki, Raymond Taetle, Agostino Tafuri, Naoki Takezako, Hava Üsküdar Teke, Mirja Vapaatalo, George Vassilopoulos, Amit Verma, Sarah Vidito, Luisa Viterbo, Filiz Vural, Xiang Sean Wang, Munci Yağci, Andrew Yee
Journal: The Lancet Oncology (2019)
Cancer screening must be made more convenient to suit busy lifestyles, says NHS report
Authors: Jacqui Thornton
Journal: BMJ (2019)

The NHS should make booking screening appointments as “simple as booking a plane ticket online,” with appointments out of hours and text reminders to boost uptake, an interim report by Mike Richards has recommended.1

Richards, the first NHS cancer director and former chief inspector of hospitals for the Care Quality Commission, is leading an overhaul of national cancer screening programmes in England.

The interim report calls for practical measures throughout the NHS to make screening more convenient and reverse a longstanding decline in the proportion of people being tested.

“People live increasingly busy lives, and we need …
POST-POLYPECTOMY SURVEILLANCE IN THE ENGLISH BOWEL CANCER SCREENING PROGRAMME: MULTIVARIATE LOGISTIC REGRESSION OF FACTORS INFLUENCING ADVANCED ADENOMA DETECTION AT FIRST SURVEILLANCE
Authors: SN Bonnington, L Sharp, MD Rutter
Journal: Endoscopy (2019)

The English Bowel Cancer Screening Programme (BCSP) offers individuals aged 60 to 74 years guaiac FOB testing, with an invitation for colonoscopy if positive. Post-polypectomy surveillance is performed by quality-accredited colonoscopists within the BCSP for individuals within the screening age range.
ENDOSCOPIC FINDINGS IN PATIENTS WITH BOWEL WALL THICKENING ON EMERGENCY ROOM CT SCANS
Authors: S Adnan Mohiuddin, S Al Kaabi, J Anjilivelil Joseph
Journal: Endoscopy (2019)

Patients presenting to the Emergency Room with abdominal pain, fever or blood in stools often undergo an urgent CT scan, often revealing bowel wall thickening (BWT). The aim of the current study is to evaluate the significance of such BWT and assess predictors of significant pathology.
The combination of exercise training and sodium-glucose cotransporter-2 inhibition improves glucose tolerance and exercise capacity in a rodent model of type 2 diabetes
Authors: Melissa A. Linden, Trenton T. Ross, David A. Beebe, Matthew F. Gorgoglione, Karyn L. Hamilton, Benjamin F. Miller, Barry Braun, William P. Esler
Journal: Metabolism (2019)
CONTRIBUTION OF COLONOSCOPY AFTER AN EPISODE OF COMPLICATED DIVERTICULOSIS
Authors: S Mrabet, R Kallel, I Akkari, E Ben Jazia
Journal: Endoscopy (2019)

A colonoscopy is often indicated after an episode of complicated diverticlosis to the search for a malignant tumor of the colon. The purpose of our study is to clarify the value of this examination in patients with complicated diverticular disease of the colon.
Case 15-2019: A 55-Year-Old Man with Jaundice
Authors: Esperance A. Schaefer, Mark A. Anderson, Arthur Y. Kim, Maroun M. Sfeir
Journal: New England Journal of Medicine (2019)

A 55-year-old man with a history of opioid use disorder and hepatitis C virus infection presented to the hospital with jaundice. The alanine aminotransferase level was 2698 U per liter, the aspartate aminotransferase level 2869 U per liter, and the total bilirubin level 21.6 mg per deciliter. Additional diagnostic tests were performed.
FACTORS ASSOCIATED WITH THE PROGRESSION OF GASTRIC INTESTINAL METAPLASIA IN A LOW RISK POPULATION – A MULTICENTER, PROSPECTIVE COHORT STUDY
Authors: SAV Nieuwenburg, MC Mommersteeg, TJ Tang, MP Anten, I Prytz-Berset, E Witteman, F ter Borg, GD den Hartog, MJ Bruno, MP Peppelenbosch, M Doukas, EJ Kuipers, MCW Spaander
Journal: Endoscopy (2019)

Gastric cancer (GC) is preceded by several gastric precursor lesions (GPL) which makes it suitable for surveillance. For low risk areas method and frequency of endoscopic surveillance is still under debate. This study aims to identify high and low risk subjects for progression of GPL to prevent unnecessary performed endoscopies. Patient characteristics and previously described discriminative serum markers at baseline (pepsinogens (PG) and gastrin-17) are assessed to predict progression of PGL.
High-Flow Oxygen Therapy for Respiratory Failure in Immunocompromised Patients
Authors: Jean-Pierre Frat, Rémi Coudroy, Arnaud W. Thille
Journal: JAMA (2019)

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Anthropometric Risk Factors for Cancers of the Biliary Tract in the Biliary Tract Cancers Pooling Project
Authors: Sarah S. Jackson, Alison L. Van Dyke, Bin Zhu, Ruth M. Pfeiffer, Jessica L. Petrick, Hans-Olov Adami, Demetrius Albanes, Gabriella Andreotti, Laura E. Beane Freeman, Amy Berrington de González, Julie E. Buring, Andrew T. Chan, Yu Chen, Gary E. Fraser, Neal D. Freedman, Yu-Tang Gao, Susan M. Gapstur, J. Michael Gaziano, Graham G. Giles, Eric J. Grant, Francine Grodstein, Patricia Hartge, Mazda Jenab, Cari M. Kitahara, Synnove F. Knutsen, Woon-Puay Koh, Susanna C. Larsson, I-Min Lee, Linda M. Liao, Juhua Luo, Emma E. McGee, Roger L. Milne, Kristine R. Monroe, Marian L. Neuhouser, Katie M. O’Brien, Ulrike Peters, Jenny N. Poynter, Mark P. Purdue, Kim Robien, Dale P. Sandler, Norie Sawada, Catherine Schairer, Howard D. Sesso, Tracey G. Simon, Rashmi Sinha, Rachael Z. Stolzenberg-Solomon, Shoichiro Tsugane, Renwei Wang, Elisabete Weiderpass, Stephanie J. Weinstein, Emily White, Alicja Wolk, Jian-Min Yuan, Anne Zeleniuch-Jacquotte, Xuehong Zhang, Katherine A. McGlynn, Peter T. Campbell, Jill Koshiol
Journal: Cancer Research (2019)

Abstract Biliary tract cancers are rare but highly fatal with poorly understood etiology. Identifying potentially modifiable risk factors for these cancers is essential for prevention. Here we estimated the relationship between adiposity and cancer across the biliary tract, including cancers of the gallbladder (GBC), intrahepatic bile ducts (IHBDC), extrahepatic bile ducts (EHBDC), and the ampulla of Vater (AVC). We pooled data from 27 prospective cohorts with over 2.7 million adults. Adiposity was measured using baseline body mass index (BMI), waist circumference, hip circumference, waist-to-hip, and waist-to-height ratios. HRs and 95% confidence intervals (95% CI) were estimated using Cox proportional hazards models adjusted for sex, education, race, smoking, and alcohol consumption with age as the time metric and the baseline hazard stratified by study. During 37,883,648 person-years of follow-up, 1,343 GBC cases, 1,194 EHBDC cases, 784 IHBDC cases, and 623 AVC cases occurred. For each 5 kg/m2 increase in BMI, there were risk increases for GBC (HR = 1.27; 95% CI, 1.19–1.36), IHBDC (HR = 1.32; 95% CI, 1.21–1.45), and EHBDC (HR = 1.13; 95% CI, 1.03–1.23), but not AVC (HR = 0.99; 95% CI, 0.88–1.11). Increasing waist circumference, hip circumference, waist-to-hip ratio, and waist-to-height ratio were associated with GBC and IHBDC but not EHBDC or AVC. These results indicate that adult adiposity is associated with an increased risk of biliary tract cancer, particularly GBC and IHBDC. Moreover, they provide evidence for recommending weight maintenance programs to reduce the risk of developing these cancers. Significance: These findings identify a correlation between adiposity and biliary tract cancers, indicating that weight management programs may help minimize the risk of these diseases.
POLYPECTOMY IN SCREENING COLONOSCOPIES – ARE WE FOLLOWING THE PUBLICATION OR THE GUIDELINES?
Authors: D Pammer, E Waldmann-Kammerlander, D Penz, A Asaturi, A Hinterberger, B Majcher, A Szymanska, M Trauner, M Ferlitsch
Journal: Endoscopy (2019)

The European Society of Gastrointestinal Endoscopy (ESGE) guidelines for colorectal polypectomy recommends cold snare polypectomy for all diminutive (≤5 mm) and small polyps between 6 – 10 mm. In a publication from Britto-Arias the forceps resection rates (FRR) for polyps ≥5 mm were 22,75% in hospitals and 52,58% in private practices. The aim of this study was to compare if the publication of own results or publication of the guidelines has more impact on the reduction of FRRs of polyps ≥5 mm.
DIGITAL, SINGLE-OPERATOR CHOLANGIOPANCREATOSCOPY IN THE DIAGNOSIS AND MANAGEMENT OF PANCREATOBILIARY DISORDERS: RESULTS FROM A SINGLE TERTIARY CENTER
Authors: R Hustak, J Usak, F Zavada, J Martinek
Journal: Endoscopy (2019)

A new digital cholangioscopy (SPY DS) provides higher-resolution imaging of the pancreatobiliary tract. The aims of our study were to assess:
ENDOSCOPIC SUBMUCOSAL DISSECTION OF RECTAL SUPERFICIAL TUMORS WITH A NEW ENDOSCOPIC PLATFORM: THE ORISE TISSUE RETRACTOR SYSTEM. A MULTICENTER EUROPEAN SERIES
Authors: R Maselli, PA Galtieri, PJ Belletrutti, F D'Amico, L Varytimiadis, EA Albizu, A Repici
Journal: Endoscopy (2019)

Endoscopic submucosal dissection (ESD) is accepted worldwide for resection of most superficial tumors > 20 mm in the GI. The main challenges of ESD are related to the instability of the operative field and the lack of tissue traction. The ORISE Tissue Retractor System (TRS, Boston Scientific) is a new endoscopic platform designed to overcome these limitations. Aim of this study is to assess the efficacy and safety of the TRS used in the first human procedures in three different European centers.
Gestion des perforations digestives hautes iatrogènes endoscopiques: Fermeture par clip(s) et prothèse métallique couverte versus clip OTS seul
Authors: C Fortier-Beaulieu, C Gomercic, JM Gonzalez, G Bertrand, M Pioche, T Ponchon, T Piche, M Barthet, G Vanbiervliet
Journal: Endoscopy (2019)

Les perforations iatrogènes digestives per endoscopiques, sont associées à une morbidité et une mortalité significative. À ce jour il n'existe pas de données comparant l'utilisation d'une prothèse métallique complètement couverte en complément d'une fermeture par clips versus l'utilisation d'un clip over-the-scope (OTSC) seul dans la gestion endoscopique de ces complications en site oesophagien ou duodénal. Le but principal de l'étude était de comparer l'efficacité de la fermeture endoscopique par OTSC seul versus clips et prothèse métallique complètement couverte extirpable en cas de perforation oesophagienne ou duodénale iatrogénique. Les objectifs secondaires étaient de comparer les deux techniques en termes de complications, de durée d'hospitalisation, et de durée du jeun dans les suites.
The adipokine receptor CAP1 regulates breast cancer cell proliferation
Authors: M. Bergqvist, S. Borgquist, A.H. Rosendahl
Journal: Annals of Oncology (2019)

Background: The adipokine resistin is linked to insulin resistance and has been shown to be upregulated in breast cancer patients. Previously we demonstrated that high levels of newly identified resistin receptor Adenylate Cyclase-Associated Protein-1 (CAP1) in breast tumors was associated with impaired prognosis. We here aim to delineate the molecular linkage between resistin, CAP1 and breast cancer prognosis. Methods: In estrogen receptor (ER)-positive T47D and ER-negative MDA-MB-231 breast cancer cells, CAP1 expression was silenced by 80-90% using small interfering RNA. Functional effects of reduced CAP1 expression and resistin exposure on cell proliferation, colony formation, and signaling pathways were subsequently investigated. Results: Initial experiments showed that CAP1 knock down resulted in reduced proliferation of both ER-positive T47D and ER-negative MDA-MB-231 cells by approximately 35 and 40%, respectively, P < 0.0001. CAP1 knock down further decreased the colony formation of T47D and MDA-MB-231 cells by 15 and 20%, respectively, compared with control. Resistin-stimulated T47D cells displayed increased CAP1 and STAT3 protein expression. Resistin exposure induced STAT3 activation in MDA-MB-231 cells, which was reduced following CAP1 knock down. Conclusions: These results indicate that CAP1 is mechanistically important for both ER-positive and ER-negative breast cancer cell proliferation, supporting our earlier clinical results. This could be mediated by the putative resistin-CAP1-STAT3 signaling pathway. Further clinical and experimental studies are ongoing to elucidate the role of resistin-CAP1 in breast cancer prognosis. These studies could provide a biological insight into how factors contributing to obesity and insulin resistance could impact breast cancer. Legal entity responsible for the study: Lund University. Funding: Swedish Cancer Society, the Swedish Research Council, the Governmental Funding of Clinical Research within the National Health Service (ALF), the Lund University Hospital Fund, the Swedish Breast Cancer Group (BRO), the Albert Pahlsson Foundation, the Mrs. Berta Kamprad Foundation, the Gyllenstienska Krapperup Foundation and the Royal Physiographic Society in Lund. Disclosure: All authors have declared no conflicts of interest.
PERIPROCEDURAL SAFETY PROFILE OF PERORAL ENDOSCOPIC MYOTOMY (POEM)
Authors: D Drazilova, Z Vackova, T Hucl, P Stirand, E Kieslichová, R Janousek, J Spicak, J Martinek
Journal: Endoscopy (2019)

POEM has become a standard treatment for achalasia due to its efficacy and safety. Nevertheless, POEM remains an invasive intervention carrying risk of complications. The aim was to assess the perioperative complications of patients undergoing POEM at our institution.