tbuckley/cabot-search huggingface dataset:
OP0338 Relationship of provider density on total joint replacement outcomes
Authors: B. Mehta, J. Szymonifka, S.A. Dey, I.Y. Navarro-Millan, L.A. Mandl, A.R. Bass, L.A. Russell, M.L. Parks, M.P. Figgie, J.T. Nguyen, S.M. Goodman
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> The proportion of providers in a geographical location (provider density) has been associated with improved surgical outcomes in hand and wrist surgery, appendicitis and other high-volume procedures, demonstrating the importance of access to care. <h3>Objectives</h3> The purpose of this study is to assess the association of provider density with Total Knee Replacement (TKR) and Total Hip Replacement (THR) outcomes. <h3>Methods</h3> Individual patient-level variables were obtained from a single institution TKR and THR registry between 5/1/07 and 2/1/11. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and function scores at baseline and 2 years after elective TKR and THR were collected and retrospectively analysed. We included patients living in New York, Connecticut and New Jersey which is the catchment area for the hospital. Individuals' geocodable addresses were used to obtain the number of primary care physicians (PCPs) and specialists in each census tract using the ArcGIS software. Provider density was calculated and broken down into percentage quartiles. Comparisons were made using Kruskal-Wallis tests. <h3>Results</h3> A total of 3606 TKR, and 4295 THR patients were included. (figure 1) Mean number of PCPs were 5.4(SD 9.5) and specialists were 15.8(SD 41.1) per census tract. The median number of PCPs were 2 (IQR 1, 6) and specialists were 3 (IQR 1, 13). Neighbourhood poverty or education correlated poorly with the number of PCPs and specialists. Baseline WOMAC pain and function scores (table 1) are statistically significantly better in neighbourhoods with a higher proportion of specialists, but not PCPs. These differences were no longer present 2 years after surgery. <h3>Conclusions</h3> Patients from neighbourhoods with fewer specialists seek arthroplasty with worse baseline pain and function than those from neighbourhoods with more specialists. However, once these patients receive arthroplasty (i.e. specialty care), these differences resolve by 2 years. These data suggest that once a patient can access specialty care in the health care system, their outcomes improve despite worse baseline pain and function. <h3>Disclosure of Interest</h3> B. Mehta: None declared, J. Szymonifka: None declared, S. Dey: None declared, I. Navarro-Millan: None declared, L. Mandl Grant/research support from: Boehringer-Ingelheim, A. Bass Grant/research support from: Abbott, Pfizer, L. Russell: None declared, M. Parks Grant/research support from: Zimmer, Consultant for: Zimmer, M. Figgie Shareholder of: Mekanika, J. Nguyen: None declared, S. Goodman: None declared
A Novel Oral Histone Deacetylase Inhibitor Chidamide Is Highly Effective and Well-Tolerated in Adult Early T-Cell Precursor and Ph-like Acute Lymphoblastic Leukemia
Authors: Hongsheng Zhou, Ya Gao, Qiang Wang, Rui Cao, Zhongxin Zhen, Qiuli Li, Dainan Lin, Linlin Zhou, Changxin Yin, Han He, Xiaoli Liu, Bing Z Carter, Qifa Liu
Journal: Blood (2018)
Prognostic Role of Neutrophil to Lymphocyte Ratio (NLR) in Myelofibrosis Patients Treated with Ruxolitinib: A Multi-Center Experience
Authors: Alessandra Romano, Francesca Palandri, Lucia Masarova, Massimiliano Bonifacio, Nicola Polverelli, Elena Maria Elli, Alessandra Iurlo, Micaela Bergamaschi, Giulia Benevolo, Alessia Tieghi, Nicola Sgherza, Francesco Cavazzini, Alessandro Isidori, Gianni Binotto, Costanza Bosi, Monica Crugnola, Lucia Catani, Luigi Scaffidi, Daniele Cattaneo, Umberto Vitolo, Antonio Cuneo, Gianpietro Semenzato, Franco Aversa, Michele Cavo, Nicola Vianelli, Daniela Bartoletti, Luca Scalise, Giuseppe A. Palumbo, Francesco Di Raimondo, Srdan Verstovsek
Journal: Blood (2018)
AB1251 Quality of inpatient referrals to rheumatology in an irish tertiary referral hospital
Authors: K. Murray, N. Rutledge, Q. Shah, D.J. Veale
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> A previous audit of inpatient referrals to our service found 21% were vasculitides, 20% inflammatory arthritides, 19% crystal arthropathies, and 16% connective tissue disease. It was felt that many of these referrals lacked appropriate investigations (such as inflammatory markers) prior to rheumatology review. <h3>Objectives</h3> Prior to transitioning from handwritten to electronic consults, we wanted to examine the data given in inpatient referrals to our service. <h3>Methods</h3> All available consults (n=81) were reviewed. We assessed whether the age/date of birth, gender, location, duration of symptoms, medications, clinical examination findings, reason for consult, urgency and suspected diagnosis had been written on the consult request form. We examined what investigations were detailed (any blood result, C Reactive Protein (CRP) value and any imaging result) and what referrer details were given (name, contact details, consultant responsible). <h3>Results</h3> In 99% of cases, patients age or date of birth was given by the referring team. 84% detailed gender. 78% contained ward. 68% contained bed number. 56% listed urgency. 96% indicated reason for consult. 30% listed duration of symptoms. 21% detailed whether patient known to rheumatology service. 57% gave suspected diagnosis. 33% gave medications. 42% detailed clinical examination findings. 41% reported any blood test. 27% gave a CRP. 44% detailed imaging findings. 49% contained referrer name. 80% had referrer contact details. 70% gave referring consultant. <h3>Conclusions</h3> Overall, it was felt many of the inpatient referrals to our service lacked potentially important details. Less than half of consult requests included duration of symptoms, medications, examination findings, blood test results or referrer name. We will soon be transitioning to an electronic referral system and all of these data points must be entered prior to submission of the consult. Hopefully, this will improve the quality of care we deliver to our patients. <h3>Disclosure of Interest</h3> None declared
Abstract 056: Serum Metabolomic Profile of the Dietary Approaches to Stop Hypertension (DASH) Dietary Pattern
Authors: Casey M Rebholz, Alice H Lichtenstein, Zihe Zheng, Lawrence J Appel, Josef Coresh
Journal: Circulation (2018)

Introduction: The DASH dietary pattern emphasizes vegetables, fruits, and low-fat dairy products and is associated with improved cardiometabolic outcomes. No biomarkers exist for assessing adherence to this dietary pattern. The objective of the study was to use metabolomics to identify serum compounds associated with the DASH diet. Methods: We conducted untargeted metabolomic profiling in stored serum specimens collected from participants at the end of an 8-week multi-center, randomized, controlled feeding study (N=218) comparing the DASH diet to a diet typical of intake in the U.S. (control). Multivariable linear regression was used to compare the association of individual log-transformed metabolites between the two diets after adjusting for age, sex, race, education, body mass index, and hypertension. Partial least squares-discriminant analysis was used to identify a composite of compounds that discriminate between the DASH and control diets. The area under the curve was calculated as the cumulative ability to distinguish between diets. Results: Serum levels of 97 known metabolites were significantly different among participants randomized to the DASH diet compared to the control diet at the Bonferroni threshold (p&lt;6.11x10 -5 ; Figure ). The majority of these 97 metabolites were lipids (n=64; 66.0%), followed by amino acids (n=15), xenobiotics including food components (n=10), cofactors and vitamins (n=6), carbohydrate (n=1), and nucleotide (n=1). The ten most influential metabolites for discriminating between the DASH and control diets were: N-methylproline, stachydrine, tryptophan betaine, theobromine, 7-methylurate, chiro-inositol, 3-methylxanthine, methyl glucopyranoside, β-cryptoxanthin, and 7-methylxanthine (C statistic=0.986). Conclusion: An untargeted metabolomic platform identified a broad array of serum metabolites that differed between the DASH and control dietary patterns. The composite of top ten metabolites may be used to assess adherence to the DASH dietary pattern.
Eating more fibre linked to reduced risk of non-communicable diseases and death, review finds
Authors: Susan Mayor
Journal: BMJ (2019)

People consuming high levels of dietary fibre and whole grains have lower risk of all cause and cardiovascular mortality and incidence of common non-communicable diseases, including coronary heart disease and type 2 diabetes, than those eating less fibre, a series of systematic reviews and meta-analyses1 has found.

“Our findings provide convincing evidence for nutrition guidelines to focus on increasing dietary fibre and on replacing refined grains with whole grains. This reduces incidence risk and mortality from a broad range of important diseases,” said the researchers, led by Jim Mann from the University of Otago, New Zealand.

The average consumption of dietary fibre by adults across the world is …
Role of Immunotherapy in the Management of Locally Advanced and Recurrent/Metastatic Cervical Cancer
Authors: Brandon A. Dyer, Dmitriy Zamarin, Ramez N. Eskandar, Jyoti M. Mayadev
Journal: Journal of the National Comprehensive Cancer Network (2019)

Despite combined therapeutic approaches, there is an unmet clinical need to identify effective strategies for improved patient outcomes in treating locally advanced and metastatic cervical cancer (CC). Immunotherapy is emerging as a novel therapeutic approach in this disease for which the causative agent, human papillomavirus (HPV), has dynamic, complex immunomodulatory effects. This review explores the biologic rational of immuno-oncology in the treatment of CC and discusses the initial clinical efficacy, ongoing clinical trials, and rationale for combined multimodal treatment approaches for locally advanced and recurrent/metastatic CC. The utility of immune checkpoint inhibitors is explored, including anti–cytotoxic T-lymphocyte antigen-4 (CTLA-4), PD-1, and PD-L1. Preliminary data supporting the combination of radiotherapy and immunotherapy and areas of active drug development for CC are also reviewed.
Face masks reduce the release of pseudomonas aeruginosa cough aerosols when worn for clinically relevant periods (Correspondence)
Authors: Rebecca Stockwell, Michelle Wood, Congrong He, Laura Sherrard, Emma Ballard, Timothy Kidd, Graham Johnson, Luke Knibbs, Lidia Morawska, Scott Bell
Journal: American Journal of Respiratory and Critical Care Medicine (2018)

We recruited 25 people with CF and chronic P. aeruginosa infection (6) from the Adult Cystic Fibrosis Centre, The Prince Charles Hospital, Brisbane, Australia. Ten healthy volunteers were recruited from hospital and research staff to assess mask comfort and mask weight change. All participants performed up to five randomly ordered tests in a validated cough system (7): uncovered cough, coughing with surgical mask worn for 10 minutes, coughing with surgical mask worn for 20 minutes, coughing with surgical mask worn for 40 minutes, and coughing with N95 mask worn for 20 minutes (3, 7). The N95 test was an optional test based on the poor comfort ratings observed in our earlier mask study (3).
FRI0092 The association of psychological stress with inflammation in patients with clinically suspect arthralgia – a study during rheumatoid arthritis development
Authors: A.C. Boer, R.M. ten Brinck, A.W.M. Evers, A.H.M. van Der Helm – van Mil
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Within established Rheumatoid Arthritis (RA), stress can have pro-inflammatory effects by activating the immune system via the hypothalamic-pituitary-adrenal axis and the autonomic nervous system. It is unknown if stress-levels promote also inflammation during RA-development. <h3>Objectives</h3> We studied whether the psychological stress response was increased in Clinically Suspect Arthralgia (CSA) and if this associated with inflammation at presentation with arthralgia and with progression to clinical arthritis. <h3>Methods</h3> In 241 CSA-patients, psychological stress was measured by the Mental Health Inventory (MHI-5) and the Perceived Stress Scale (PSS-10) at first presentation and during follow-up. Systemic inflammation was measured by C-reactive protein (CRP) and joint inflammation by 1.5T-MRI of wrist-, MCP- and MTP-joints. <h3>Results</h3> At baseline, 10% of CSA-patients had a high psychological stress-response according to the MHI-5. This was not different for patients presenting with or without an elevated CRP, with or without subclinical MRI-detected inflammation and for patients who did or did not develop arthritis. Similar findings were obtained with the PSS-10. When developing clinical arthritis, the percentage of patients with 'high psychological stress' increased to 31% (p=0.025); during the first year of treatment this decreased to 8% (p=0.020). 'High psychological stress' in non-progressors remained infrequent over time (range 7%–13%). Stress was associated with fatigue (p=0.003) and wellbeing (p&lt;0.001). <h3>Conclusions</h3> Psychological stress was not increased in the phase of arthralgia, raised at the time of diagnoses and decreased thereafter. This temporal-relationship, and the lack of association with inflammation in arthralgia, argue against psychological stress having a significant contribution to inflammatory arthritis development. <h3>Disclosure of Interest</h3> None declared
Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction
Authors: Daniel A. Nation, Melanie D. Sweeney, Axel Montagne, Abhay P. Sagare, Lina M. D’Orazio, Maricarmen Pachicano, Farshid Sepehrband, Amy R. Nelson, David P. Buennagel, Michael G. Harrington, Tammie L. S. Benzinger, Anne M. Fagan, John M. Ringman, Lon S. Schneider, John C. Morris, Helena C. Chui, Meng Law, Arthur W. Toga, Berislav V. Zlokovic
Journal: Nature Medicine (2019)
Oleic Acid Can Make Heart Claim Without Hard Evidence
Authors: Rebecca Voelker
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lessons from Nature: A Novel Class of TET Inhibitors for TET2 Mutant Associated Diseases
Authors: Yihong Guan, Anand D. Tiwari, Metis Hasipek, Dale Grabowski, Yvonne Parker, Cassandra M. Hirsch, Amy C Graham, Yasunobu Nagata, Bartlomiej P. Przychodzen, Aziz Nazha, Daniel Lindner, Tomas Radivoyevitch, James G Phillips, Jaroslaw P. Maciejewski, Babal K. Jha
Journal: Blood (2018)
The association between obesity and hyperhidrosis: A nationwide, cross-sectional study of 2.77 million Israeli adolescents
Authors: Nadav Astman, Itay Friedberg, Jakob D. Wikstrom, Estela Derazne, Orit Pinhas-Hamiel, Arnon Afek, Michal Freireich-Astman, Aviv Barzilai, Tarif Bader, Gilad Twig
Journal: Journal of the American Academy of Dermatology (2019)
Abstract 14833: Ventricular Interdependence by Means of Preload Tress Echocardiography in Patients With Pulmonary Hypertension
Authors: hiroyuki sano, Hidekazu Tanaka, Yoshiki Motoji, Jun Mukai, Makiko Suto, Hiroki Takada, Fumitaka Soga, Kumiko Dokuni, Yutaka Hatani, Hiroki Matsuzoe, Keiko Hatazawa, Junichi Ooka, Kensuke Matsumoto, Kazuhiko Nakayama, Noriaki Emoto, Ken-ichi Hirata
Journal: Circulation (2017)

Background: Pulmonary hypertension (PH) is characterized by a marked and sustained elevation of pulmonary vascular resistance, leading to an increase in pulmonary artery pressure, and right ventricular (RV) failure. RV pressure overload in PH patients can affect left ventricular (LV) performance as a result of ventricular interdependence, however, association of functional reserve with ventricular interdependence remains uncertain. Thus, the aim of this study was to investigate the effect of preload stress echocardiography on ventricular interdependence in PH patients by means of leg-positive pressure (LPP) maneuver. Methods: We studied 43 PH patients with pulmonary arterial hypertension, and chronic thromboembolic pulmonary hypertension. All patients underwent echocardiography at rest and during LPP maneuver. RV function was calculated by averaging peak speckle-tracking longitudinal strain from RV free-wall (RV free-wall strain). RV contractile reserve was assessed as a relative change in RV free-wall st...
SAT0070 Role of c/ebpΒ in 1,25d-induced activation of rankl expression
Authors: S. Jo, Y.L. Lee, I.-H. Sung, T.-H. Kim
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> 1 alpha 25-dihydroxyvitamin D3 (1,25D) is the active form of vitamin D3, which is responsible for osteoblast activation, subsequently bone formation. Although recent studies have shown that 1,25D stimulates RANKL expression in osteoblast differentiation<sup>1</sup>, its molecular mechanism of action is not fully understood. <h3>Objectives</h3> The aims of this study were to evaluate cellular response of human bone-derived cells to 1,25D treatment by observing expression during osteoblast differentiation <h3>Methods</h3> In this study, MG63, SaOS2, and primary bone-derived cells (BdCs) were cultured and isolated to further elucidate the effect of 1,25D on osteoblasts. Those were incubated in osteogenic medium (ascorbic acid, beta-glycerol phosphate, and dexamethasone) for 1, 3, and 7 days with or without 20 µM 1,25D. The osteoblast activity and differentiation status were evaluated by intercellular Alkaline Phosphatase (ALP) activity, ALP staining, Alizarin Red S (ARS) staining, and hydroxyapatite staining. In this situation, C/EBPβ gene manipulation with siRNA or overexpression system were subjected to report assay of human RANKL promoter, quantitative PCR(qPCR), immunoblotting and immunostaining of osteoblastic gene expression (alkaline phosphatase, osteocalcin, vitamin D3 receptor, RANKL, and C/EBPβ etc.) <h3>Results</h3> 1,25D promotes osteoblast differentiation and expression of osteogenic markers in three different cells. Intriguingly, treatment of 1,25D to those cells are accompanied by stabilising C/EBPβ proteins and stimulating RANKL expression. Moreover, Overexpression of C/EBPβ significantly increases RANKL mRNA and protein. In contrast, suppression of C/EBPβ decreases RANKL expression. Thus, C/EBPβ is a key mediator involved in 1,25D induced RANKL expression. <h3>Conclusions</h3> our preliminary data indicated that human bone-derived cells response to vitamin D3 promoted RANKL expression via activation of C/EBPβ, and enhanced osteoblast activity and differentiation. This study provides insight into the molecular mechanism of RANKL expression and osteoblast activation in human bone-derived cells response to 1,25D. <h3>Reference</h3> [1] Both ligandand VDR expression levels critically determine the effect of 1α, 25-dihydroxyvitamin-D3 on osteoblast differentiation. J Steroid Biochem Mol Biol2017Sep 6, PMID:28887147. DOI:10.1016/j.jsbmb.2017.09.005 <h3>Disclosure of Interest</h3> None declared
Immune Thrombocytopenia Complications: Implications on Length of Stay and and Mortality
Authors: Manoj P Rai, Prabhjot Singh Bedi, Justin D. Kaner, Prajwal Dhakal, Samanjit Kaur Kandola, Nishant Tageja, Heather Laird-Fick, Marwan S Abougergi, James B. Bussel, Stanley M. Marks
Journal: Blood (2018)
AB0277 Leptin and adiponectin levels in rheumatoid arthritis patients
Authors: N. Nicolaou, J. Joseph, I.N. Bruce
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Rheumatoid Arthritis (RA) is a chronic inflammatory autoimmune disorder characterised by systemic inflammation of joints, in particular the synovial membrane, cartilage and bone. Leptin (LEP) and adiponectin (ADIP) belong to a distinct group of biological molecules, adipokines which are secreted by white adipose tissue and have a central role in energy storage and metabolism. <h3>Objectives</h3> To compare fasting serum LEP and ADIP in RA to healthy controls and to investigate whether fasting LEP and ADIP serum levels change following a change in RA treatment. <h3>Methods</h3> Male and female subjects aged 18 years old or above with RA, fulfilling the 2010 ACR/EULAR classification criteria and having DAS28 score &gt;4.2, were recruited and followed up for 90 days. LEP and ADIP levels were measured using ELISA. Fasting glucose, lipids and insulin levels were also measured as indicating factors for co-morbidities. The associations between RA patients at baseline and controls were assessed by uncorrelated/unrelated t-test analyses while associations between RA patients at baseline, day 30 and day 90 were assessed by one-way correlated/related analysis of variance. <h3>Results</h3> We studied 30 RA patients with mean (SD) age of 56.33 (13.84) years, of whom 24 (80%) were female and 15 healthy individuals with mean (SD) age of 53.80 (13.97) years, of whom 12 (80%) were female. LEP and ADIP levels for control subjects were 28.36 (15.08) ng/mL (p=NS vs RA at baseline) and 14.76 (4.42) μg/mL (p&lt;0.05 vs RA at baseline) (table 1). Over 90 days DAS28 and HAQ score improved significantly in RA patients. LEP levels for RA patients were 29.65 (18.17) ng/mL at baseline, 30.81 (17.65) ng/mL at day 30 and 25.90 (15.01) ng/mL at day 90 (p=NS) whilst ADIP levels for RA patients were 16.78 (8.73) μg/mL at baseline, 16.65 (8.70) μg/mL at day 30 and 15.44 (7.24) μg/mL at day 90 (p=NS) (table 2). <h3>Conclusions</h3> ADIP was significantly higher in RA patients at baseline compared to control subjects and there was a trend towards normalisation of levels as inflammation improved. The role of ADIP in active RA remains unclear and further examination of the site of origin of ADIP as well as its role in pro- and anti-inflammatory pathways warrants further study. <h3>Disclosure of Interest</h3> None declared