tbuckley/cabot-search huggingface dataset:
Prognostic significance of recurring chromosomal abnormalities in transplanted patients with acute myeloid leukemia
Authors: Jonathan Canaani, Myriam Labopin, Maija Itälä-Remes, Didier Blaise, Gerard Socié, Edouard Forcade, Johan Maertens, Depei Wu, Ram Malladi, Jan J. Cornelissen, Anne Huynh, Jean Henri Bourhis, Jordi Esteve, Mohamad Mohty, Arnon Nagler
Journal: Leukemia (2019)
STENT EXPANSION AND ENDOTHELIAL SHEAR STRESS IN BIFURCATION LESION: COMPARISON OF KISSING BALLOON INFLATION AND PROXIMAL OPTIMIZING TECHNIQUE
Authors: Naotaka Okamoto, Yuliya Vengrenyuk, Samit Bhatheja, Surbhi Chamaria, Asaad Khan, Eisha Gupta, Vishal Kapur, Nitin Barman, Choudhury Hasan, Joseph Sweeny, Usman Baber, Roxana Mehran, Jagat Narula, Samin Sharma, Annapoorna Kini
Journal: Journal of the American College of Cardiology (2019)
DECREASE IN CAROTID ARTERY THERMAL HETEROGENEITY OF PATIENTS WITH CORONARY ARTERY DISEASE UNDER OPTIMAL MEDICAL THERAPY
Authors: George Benetos, Konstantinos Toutouzas, George Oikonomou, Koutagiar Iosif, Spiros Galanakos, Maria Karmpalioti, Nikolaos Barampoutis, Periklis Davlouros, Elias Siores, Dimitrios Tousoulis
Journal: Journal of the American College of Cardiology (2019)
PROSPECTIVE REGISTRY OF YOUNG WOMEN WITH MI: EVALUATING THE PREVALENCE AND LONG-TERM IMPACT OF NON-ATHEROSCLEROTIC CORONARY ARTERY DISEASE (PRYME STUDY)
Authors: Jacqueline W.L. Saw, Eve Aymong, Andrew Starovoytov, Mahraz Parvand, Tara Sedlak, Karin Humphries, G.B. John Mancini
Journal: Journal of the American College of Cardiology (2019)
CORONARY FLOW RESERVE COULD HAVE PREDICTABILITY FOR MAJOR ADVERSE CARDIO AND CEREBROVASCULAR EVENT IN THE HEMODIALYSIS POPULATION, EVEN IN THE PATIENTS WITHOUT MYOCARDIAL PERFUSION ABNORMALITY
Authors: Satoru Ohshima, Norio Umemoto, Yusuke Izumi, Ryuta Ito, Sakakibara Takashi, Toyoaki Murohara
Journal: Journal of the American College of Cardiology (2019)
A Genome-Wide CRISPR/Cas9 Knockout Screen Identifies BEND3 As a Determinant of Sensitivity to UBA1 Inhibition in Acute Myeloid Leukemia
Authors: Samir H Barghout, Neil MacLean, G. Wei Xu, Geethu Thomas, Zachary Blatman, Rose Hurren, Aaron D Schimmer
Journal: Blood (2018)
THE GRAVID ATRIUM: AN UNCOMMON CAUSE OF SHORTNESS OF BREATH IN PREGNANCY AND THE EXPANDING ROLE OF CARDIAC MAGNETIC RESONANCE IMAGING IN THE EVALUATION OF CARDIAC MASSES
Authors: Rajeev Anchan, Kalie Kebed, Tae Song, Sarosh Rana, Roberto Lang, Amit Patel, Karima Addetia
Journal: Journal of the American College of Cardiology (2019)
ASSESSMENT OF RIGHT VENTRICULAR FUNCTION IN ADVANCED HEART FAILURE PATIENTS USING RIGHT HEART CATHETERIZATION AND SPECT VENTRICULOGRAPHY
Authors: Vojtech Melenovsky, Marek Tupy, Nevenka Solar, Adrian Reichenbach, Hikmet Al-Hiti, Tereza Havlenova, Luca Monzo, Ivan Netuka, Josef Kautzner
Journal: Journal of the American College of Cardiology (2019)
Abstract 16095: Attenuation of Aortic Valve Calcification With Local Delivery of Bisphosphonates
Authors: Andreas Synetos, Konstantinos Toutouzas, Maria Drakopoulou, Konstantinos Stathogiannis, Giorgos Agrogiannis, Konstantinos Anagnostopoulos, Apostolos Papalois, Dennis Cokkinos, Efstratios Patsouris, Dimitris Tousoulis
Journal: Circulation (2016)

Introduction: Bisphosphonates have been proven to have a beneficial effect on inhibition of calcification in arterial wall of an experimental model. Hypothesis: To evaluate the safety and effective...
EFFECT OF PREOPERATIVE RENAL DYSFUNCTION ON COST AND OUTCOMES IN PATIENTS UNDERGOING CORONARY ARTERY BYPASS GRAFT IN THE UNITED STATES BETWEEN 2004-2014
Authors: Aasim Afzal, Tariq Nisar, Aayla Jamil, Aaron Kluger, Joost Felius, Parag Kale, Shelley Hall, Dan Meyer
Journal: Journal of the American College of Cardiology (2019)
Abstract 371: Cardiac Endocrinology: Biology of a Heart-derived Hormone That Regulates Body Growth
Authors: Liming Pei
Journal: Circulation Research (2018)

The endocrine system is crucial for maintaining whole-body homeostasis. Little is known regarding endocrine hormones secreted by the heart other than ANP and BNP discovered over 30 years ago. We recently identified growth differentiation factor 15 (GDF15) as a heart-derived hormone that regulates body growth. Pediatric heart disease induces GDF15 synthesis and secretion by cardiomyocytes. Circulating GDF15 in turn acts on the liver to inhibit growth hormone (GH) signaling and body growth. Blocking cardiomyocyte production of GDF15 normalizes circulating GDF15 level and restores liver GH signaling, establishing GDF15 as a bona fide heart-derived hormone that regulates pediatric body growth. Importantly, plasma GDF15 is further increased in children with concomitant heart disease and failure to thrive. In addition, we used massively parallel single-nucleus RNA-Seq to decipher cardiac cell type specific gene regulatory network that induces GDF15 transcription in heart disease condition. We further determined how GDF15 precursor is processed into mature hormone. Together these studies reveal a new endocrine mechanism (cardiac endocrinology) by which the heart coordinates cardiac function and body growth.
James A T Dyer
Authors: Joe Morrow
Journal: BMJ (2019)

James A T Dyer (“Jim”) was one of the most influential psychiatrists of his generation and led the Mental Welfare Commission for Scotland for many years, keeping its focus always on the care of those with mental disorder who had been detained. He was a quiet, gentle, and firm man, who never lost sight of what was important in the care of patients. He brought a sense of gravitas as well as professional insight to the work he carried out and raised an awareness of mental health issues in Scotland. He had a focused interest in mental health law and substantially influenced the formation and practice of mental health law in Scotland.

Jim Dyer shaped the practice of most of Scotland’s mental health law in force. Born in Arbroath, a son of the Manse, with his sister, Christine, he would comment on the dutiful way his mother faithfully fulfilled the role of a minister’s wife while at …
COMPARATIVE EFFECTIVENESS AND SAFETY OF EMPAGLIFLOZIN: AN INTERIM ANALYSIS FROM THE EMPAGLIFLOZIN COMPARATIVE EFFECTIVENESS AND SAFETY (EMPRISE) STUDY
Authors: Elisabetta Patorno, Ajinkya Pawar, Jessica M. Franklin, Mehdi Najafzadeh, Anouk Déruaz-Luyet, Kimberly G. Brodovicz, Lily G. Bessette, Martin Kulldorff, Sebastian Schneeweiss
Journal: Journal of the American College of Cardiology (2019)
Abstract P130: Infant Growth as an Effect Modifier of Genetic-lipid Associations: Evidence From a Chilean Infancy Cohort
Authors: Ann Von Holle, Kari E North, Sheila Gahagan, Estela Blanco, Misa Graff, Anne Justice, Betsy Lozoff, José Santos, Bárbara Angel, Raquel Burrows, Saroja Voruganti, Annie Green Howard
Journal: Circulation (2018)

Background: The postnatal period can function as a window of time for metabolic programming. As evidence from human observational studies is scarce, we examined the role of postnatal weight, length (linear growth), and weight-for-length (WFL) growth trajectories as effect modifiers of established single nucleotide polymorphism (SNP) associations on lipid levels in a cohort of adolescents from the Santiago Longitudinal Study (SLS) (n=484). Methods: Growth trajectories were characterized via two different approaches: nonlinear mixed effects model (SITAR) and a latent growth mixture model (LGMM). We assessed gene-environment interaction in an additive model within: 1) SITAR including product terms that accurately reflects the trichotomous genetic term, and 2) LGMM using stratified SNP-lipid associations by latent growth patterns. Bonferroni-corrected significant findings are reported. Results: SITAR models did not reveal any evidence of gene-environment interaction. In contrast, given three LGMM patterns of growth, gene-environment interactions emerge for both weight and WFL trajectories. One group of infants had lower velocity but higher acceleration; another group had medium velocity and lower acceleration; a third group had high velocity and lower acceleration. The association between the rs7412 (APOE) variant and HDL (mg/dL) was negative for the low velocity/high acceleration weight trajectory group (mean= -10.2; 95% CI = -16.0, -4.5; n~23) compared to the high velocity/low acceleration group (mean = 11.3; 95% CI = 2.6, 20; n~152). Similarly, the association (95% CI) between the rs78536982 (BAI3, LMBRD1) variant and triglycerides (log(mg/dL) was lower for the low velocity/high acceleration WFL group (-0.61; 0.84, -0.37; n~24) when compared to both the medium velocity/low acceleration (-0.09; -0.23, 0.05; n~271) and high velocity/low acceleration (0.001; -0.11, 0.11; n~189). In sex-stratified analyses, the high velocity/low acceleration group for males (n=254) had a negative association (95% CI) between the rs11076175 (CETP) variant and LDL (mg/dL) (-10.6; -16.7, -4.5; n~140) versus a positive association for the low velocity/high acceleration (12.6; 2.93, 22.2; n~114). Summary: These results demonstrate potential heterogeneity in the genetic association between lipid loci and adolescent lipid levels across different patterns of growth from 0 to 5 months. Future work to examine the role of infant growth as a causal factor in direct and indirect effects is of interest.
Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair
Authors: Jianhui Ma, Jorge A. Benitez, Jie Li, Shunichiro Miki, Claudio Ponte de Albuquerque, Thais Galatro, Laura Orellana, Ciro Zanca, Rachel Reed, Antonia Boyer, Tomoyuki Koga, Nissi M. Varki, Tim R. Fenton, Suely Kazue Nagahashi Marie, Erik Lindahl, Timothy C. Gahman, Andrew K. Shiau, Huilin Zhou, John DeGroot, Erik P. Sulman, Webster K. Cavenee, Richard D. Kolodner, Clark C. Chen, Frank B. Furnari
Journal: Cancer Cell (2019)
Abstract 18559: Inhibition of Mitochondrial Fission as a Novel Molecular Target to Attenuate Myocardial Ischemia-Reperfusion Injury: Critical Importance of the Timing of Treatment
Authors: Yi Dong, Vishnu V Undyala, Karin Przyklenk
Journal: Circulation (2013)

Background: Mitochondrial fragmentation (i.e., fission) has been implicated as: (i) a critical determinant of myocyte viability and, thus (ii) a potential molecular target for novel cardioprotective therapies. This concept is based on evidence that inhibition of fission, achieved by pharmacologic or genetic manipulation of DRP1 (dynamin-related protein 1: the key molecular regulator of fission) attenuates lethal myocardial ischemia-reperfusion injury. However, all studies have implemented treatment/genetic silencing as a pre-treatment; the effect of inhibition of fission, initiated in a therapeutically relevant manner (at reoxygenation) has, to date, not been explored. Methods: To address this issue, cultured HL-1 cells underwent 2 hrs of hypoxia + reoxygenation (R). Cells were given: (i) mdivi-1 (specific DRP1 inhibitor; 50 μM) 1 hr before hypoxia (pre-treat); (ii) mdivi-1 (50 μM) at reoxygenation (post-treatment); or (iii) vehicle. Time-matched normoxic cells served as controls. Endpoints included: (i) translocation of DRP1 to mitochondria, assessed at 2 hrs post-R; (ii) expression of cleaved caspase 3 (harbinger of apoptosis), assessed at 2 hrs post-R; and (iii) cell viability quantified by trypan blue staining at 20 hrs post-R. Results: As expected, pre-treatment with mdivi-1 inhibited translocation of DRP1 to the mitochondria (not shown), attenuated the cleavage of caspase 3 (right: p&lt;0.05), and preserved cell viability (left: p&lt;0.05 vs vehicle). Post-treatment with mdivi-1 had a similar, favorable effect on caspase 3 cleavage (right: p&lt;0.05), but, in contrast, exacerbated cell death (left: p&lt;0.0001 vs vehicle). Conclusion: We report novel evidence that mdivi-1, given at reoxygenation, has a paradoxical and dissociative effect on apoptotic vs necrotic cell death. Moreover, these data provide initial insight into an apparently complex temporal relationship between inhibition of mitochondrial fission and cardioprotection.
ONE-YEAR MORTALITY AND ASSOCIATED RISK FACTORS IN PATIENTS UNDERGOING EXTRACTION OF INFECTED CARDIAC IMPLANTABLE ELECTRONIC DEVICES AND INTRODUCTION OF A NOVEL RISK SCORE TO PREDICT ONE-YEAR MORTALITY
Authors: Stephen Tuohy, Maki Ono, Divyang Patel, Claudia Georges, Mohammad Maysara Asfari, Allen Nemeh, Antoine Addoumieh, Mingyuan Shao, Steven Gordon, Ayman Hussein, Oussama Wazni, Bruce Wilkoff, Khaldoun Tarakji
Journal: Journal of the American College of Cardiology (2019)
BAL Cell Gene Expression Is Indicative of Outcome and Airway Basal Cell Involvement in Idiopathic Pulmonary Fibrosis
Authors: Antje Prasse, Harald Binder, Jonas C. Schupp, Gian Kayser, Elena Bargagli, Benedikt Jaeger, Moritz Hess, Susanne Rittinghausen, Louis Vuga, Heather Lynn, Shelia Violette, Birgit Jung, Karsten Quast, Bart Vanaudenaerde, Yan Xu, Jens M. Hohlfeld, Norbert Krug, Jose D. Herazo-Maya, Paola Rottoli, Wim A. Wuyts, Naftali Kaminski
Journal: American Journal of Respiratory and Critical Care Medicine (2018)

Idiopathic pulmonary fibrosis (IPF) is a fatal disease with a variable and unpredictable course.
Abstract 18336: Electromagnetic Interference in Cardiac Contractility Modulation Devices
Authors: Andreas Napp, Matthias Zink, Thomas Kraus, Nikolaus Marx, Dominik Stunder
Journal: Circulation (2017)

Introduction: Cardiac contractility modulation (CCM) is a non-excitatory therapy in heart failure. Due to a missing error memory malfunctions due to electromagnetic interference (EMI) may be disreg...
DNA Damage-Response Pathway in Lymphoma Determines Interactions with Macrophages By Altered PD-L1 Expression and Exosome Formation
Authors: Daniela Vorholt, Elena Izquierdo-Alvarez, Benedict Sackey, Jan Schmitz, Nadine Nickel, Stuart Blakemore, Gero Knittel, Christian Reinhardt, Clemens-Martin Wendtner, Heiko Bruns, Michael Hallek, Christian Pallasch
Journal: Blood (2018)
Two Randomized Clinical Trials on the Treatment of Secondary Mitral Regurgitation—Contradictory or Complementary?
Authors: Gilbert H. L. Tang, Subodh Verma, Deepak L. Bhatt
Journal: JAMA Cardiology (2019)

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STATIN THERAPY IN PATIENTS WITH CEREBROVASCULAR DISEASE VERSUS CORONARY ARTERY DISEASE: INSIGHTS FROM THE PALM REGISTRY
Authors: Ying Xian, Ann Navar, Shuang Li, Zhuokai Li, Veronique Roger, Salim Virani, Peter Wilson, Anne Goldberg, Jennifer Robinson, Andrew Koren, Michael Louie, Eric Peterson, Tracy Wang
Journal: Journal of the American College of Cardiology (2019)
Histologic and Transcriptional Evidence of Subclinical Synovial Inflammation in Patients With Rheumatoid Arthritis in Clinical Remission
Authors: Dana E. Orange, Phaedra Agius, Edward F. DiCarlo, Serene Z. Mirza, Tania Pannellini, Jackie Szymonifka, Caroline S. Jiang, Mark P. Figgie, Mayu O. Frank, William H. Robinson, Laura T. Donlin, Cristina Rozo, Ellen M. Gravallese, Vivian P. Bykerk, Susan M. Goodman
Journal: Arthritis & Rheumatology (2019)

Objective Patients with rheumatoid arthritis ( RA ) in clinical remission may have subclinical synovial inflammation. This study was undertaken to determine the proportion of patients with RA in remission or with low disease activity at the time of arthroplasty who had histologic or transcriptional evidence of synovitis, and to identify clinical features that distinguished patients as having subclinical synovitis. Methods We compared Disease Activity Score in 28 joints ( DAS 28) to synovial histologic features in 135 patients with RA undergoing arthroplasty. We also compared DAS 28 scores to RNA ‐Seq data in a subset of 35 patients. Results Fourteen percent of patients met DAS 28 criteria for clinical remission ( DAS 28 &lt;2.6), and another 15% met criteria for low disease activity ( DAS 28 &lt;3.2). Histologic analysis of synovium revealed synovitis in 27% and 31% of samples from patients in remission and patients with low disease activity, respectively. Patients with low disease activity and synovitis also exhibited increased C‐reactive protein ( CRP ) ( P = 0.0006) and increased anti–cyclic citrullinated peptide (anti‐ CCP ) antibody levels ( P = 0.03) compared to patients without synovitis. Compared to patients with a “low inflammatory synovium” subtype, 183 genes were differentially expressed in the synovium of patients with subclinical synovitis. The majority of these genes (86%) were also differentially expressed in the synovium of patients with clinically active disease ( DAS 28 ≥3.2). Conclusion Thirty‐one percent of patients with low clinical disease activity exhibited histologic evidence of subclinical synovitis, which was associated with increased CRP and anti‐ CCP levels. Our findings suggest that synovial gene expression signatures of clinical synovitis are present in patients with subclinical synovitis.
UTILITY OF CARDIOPULMONARY EXERCISE TESTING IN PATIENTS WITH ASYMPTOMATIC SEVERE AORTIC STENOSIS
Authors: Sonia Fortin, Vuyisile Nkomo, Maria I. Barillas Lara, Yazan Assaf, Amanda Bonikowske, Michel Corban, Karina Gonzalez Carta, Thomas Allison, Debora Brala
Journal: Journal of the American College of Cardiology (2019)
REGURGITANT VOLUME AND LEFT VENTRICULAR END-DIASTOLIC VOLUME RATIO: A NEW PROGNOSTIC INDICE IN PATIENTS WITH SECONDARY MITRAL REGURGITATION?
Authors: Farnaz Namazi, Pieter van der Bijl, Vasileios Kamperidis, Suzanne van Wijngaarden, Nina Ajmone Marsan, Alec Vahanian, Victoria Delgado, Jeroen J. Bax
Journal: Journal of the American College of Cardiology (2019)
IMPACT OF HISTORY OF CEREBRO-VASCULAR DISEASE TO THE LONG-TERM OUTCOMES AFTER PERCUTANEOUS CORONARY INTERVENTION: INSIGHTS FROM THE SHINANO 5 YEARS REGISTRY
Authors: Chie Nakamura, Soichiro Ebisawa, Takashi Miura, Keisuke Senda, Minami Taki, Masanori Kobayashi, Masafumi Kanai, Yukari Okuma, Takashi Yanagisawa, Naoto Hashidume, Kyuhachi Otagiri, Kyoko Shoin, Noboru Watanabe, Kenichi Karube, Hiroyuki Nakajima, Tatsuya Saigusa, Yusuke Miyashita, Hisanori Yui, Shusaku Maruyama, Daisuke Kashiwagi, Ayumu Nagae, Ayako Okada, Hirohiko Motoki, Koichiro Kuwahara
Journal: Journal of the American College of Cardiology (2019)
SEX-DIFFERENCES IN CIRCULATING SOLUBLE UROKINASE-TYPE PLASMINOGEN ACTIVATOR RECEPTOR (SUPAR) LEVELS AND ITS IMPACT ON THE PROGNOSTIC SIGNIFICANCE OF SUPAR AMONG PATIENTS WITH CORONARY ARTERY DISEASE
Authors: Anurag Mehta, Chang Liu, Devinder Dhindsa, Yi-An Ko, Jeong Hwan Kim, Pratik Sandesara, Ayman Samman Tahhan, Matthew Topel, Heval Mohamed Kelli, Kasra Moazzami, Beka Bakhtadze, Ayman Alkhoder, Samir Martin, Laurence S. Sperling, Jochen Reiser, Salim Hayek, Arshed Quyyumi
Journal: Journal of the American College of Cardiology (2019)
Serum S-100B Protein Is A Predictor of Survival in Recurrent Glioma
Authors: T.J.M. van Mierlo, T.J. Postma, M.J. Vos, B.M.J. Uitdehaag, R.A. Blankenstein, J. Buter, J.C. Reijneveld, J.J. Heimans
Journal: Neuro-Oncology (2010)
CROTONOBETAINE IS A PROATHEROGENIC GUT MICROBIOTA METABOLITE OF L-CARNITINE
Authors: Robert Koeth, Miranda Culley, Zeneng Wang, Ina Nemet, Jennifer Kirsop, Elin Org, Jennifer Buffa, Xinmin Li, Bruce Levison, David Bartlett, Xiaoming Fu, Yuping Wu, Lin Li, Jonathan Smith, Joseph DiDonato, Jake Lusis, Wai Hong Tang, Stanley L. Hazen
Journal: Journal of the American College of Cardiology (2019)
EXPANDING LATIN TELEMEDICINE PROJECT: 100 MILLION COVERAGE, 700,000 SCREENED PATIENTS, AND 8,000 STEMI
Authors: Sameer Mehta, Roberto Botelho, Francisco Fernandez, Fausto Feres, Alexandre Abizaid, Jamil Cade, Marco Perin, Mauricio Prudente, Ricardo Cavalcanti, Cesar Dusilek, Nabil Hamdan, Luis Ignacio Calderon, Edgar Hurtado, Marco Alcocer Gamba, Alfredo Estrada, Odin De Los Rios, Alejandro Ricalde, Hernan Acosta, Lorena Villagran, Mario Alberto Torres, Daniel Vieira, Jorge Mazinni, Haytham Aboushi, Alejandra Frauenfelder, Gladys Pinto
Journal: Journal of the American College of Cardiology (2019)
Abstract 556: Intramyocardial EphrinA1-Fc Preserves Mitochondrial Structure and Bioenergetics Post-Myocardial Infarction
Authors: Julie Horton, Maria Torres, Kelsey McLaughlin, Randall Renegar, Uma Sharma, Smrithi Valsaraj, Omar Sharaf, K’Shylah Whitehurst, Brinda Sarathy, Darrell Neufer, Jitka A Virag
Journal: Circulation Research (2018)

EphrinA1, a receptor tyrosine kinase ligand expressed in the plasma membrane of healthy cardiomyocytes, is reduced following acute myocardial ischemia (I)/reperfusion (R) injury in mice. Intramyocardial injection of recombinant EphrinA1-Fc at the time of LAD ligation attenuated infarct injury by 46% and completely preserved cardiac function in I/R (30min I/24hrs R). This was accompanied by reduced inflammation, attenuation of apoptosis, enhanced autophagy, and modulation of metabolic pathways that promote more efficient energy utilization. To examine the mechanism by which this occurs, mitochondrial structure and function was examined in 10 wk-old B6129SF2/J male mice given intramyocardial EphrinA1-Fc or IgG-Fc at LAD occlusion and subsequently reperfused for 24hrs. Permeabilized cardiac muscle fibers were isolated from a portion of the infarct margin of the left ventricle to assess mitochondrial function and energetics. EphrinA1-Fc prevented the 30% loss (p&lt;0.005) in mitochondrial respiratory capacity in the absence of changes in H 2 O 2 emitting potential. Moreover, using a titrated creatine kinase energetic clamp, we found that EphrinA1-Fc improved the mitochondrial thermodynamic force-flow relationship by increasing OXPHOS conductance (+55% vmax, p&lt;0.005), without changes in ADP affinity. Another small portion of the infarct margin was fixed and processed for transmission electron microscopy imaging which revealed that EphrinA1-Fc treatment prevented the MI-induced loss of sarcomere alignment and mitochondrial organization along the Z disks, as well as disorganization of the cristae. There was also significantly less lipid droplet accumulation and preservation of intermitochondrial junctions. Morphometric analyses of mitochondria are in progress as are Western blot assays to identify the proteins involved. Myocardial strain analyses are also underway to explore and pinpoint regional changes in contractile function. Collectively, these data demonstrate that intramyocardial injection of EphrinA1-Fc attenuates I/R injury by preserving the mitochondrial network structure and bioenergetic capacity. The robust cardioprotection afforded by ephrinA1-Fc offers promise as a novel therapeutic for the treatment of acute MI.