THU0565 COMPARISON OF SURVIVAL RATES AMONG SUBGROUPS OF PATIENTS EVALUATED FOR FEVER OF UNKNOWN ORIGIN
Authors: Emre Bilgin, Berkan Armagan, Alper Sarı, Ertuğrul Çağrı Bölek, Bayram Farisoğulları, Gözde Kübra Yardımcı, Levent Kılıç, Ali Akdoğan, Omer Karadag, Şule Apraş Bilgen, Ali İhsan Ertenli, Sedat Kiraz, Umut Kalyoncu
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> Fever of unknown origin (FUO) is one of the most challenging clinical situations. Although several studies showed a relatively benign course of patients remained undiagnosed, long-term outcome of patients with a certain diagnosis remain non-established (1). <h3>Objectives</h3> To describe the follow-up results of patients investigated for FUO and had a certain diagnosis. <h3>Methods</h3> Data from patients who admitted to Hacettepe University Hospitals, inpatients sections of department of the internal medicine with the complaint of FUO collected prospectively from January 2015 to October 2017. Patients with an uncertain diagnosis after all diagnostic procedures excluded. Patients were divided into 3 main subgroups: rheumatologic, infectious and malignant groups. We compared Kaplan-Meier curves for all diagnosis-to-death time frames with the standart log-rank test. p&lt;0.05 was considered as statistically significant. <h3>Results</h3> Total 106 patients were included, 58(55%) of them were female. Median age was 48 (18-81) years. Patients were also divided into three subgroups: rheumatologic (RHE) (n=49, 46.2%), infectious (INF) (n=28, 26.4%) and malignant (MLG) (n=29, 27.4%) causes; adult-onset Still's disease (n=20; 41% of), tuberculosis (n=9; 32%) and lymphoma (n=19; 66%) were the most common diagnosis among groups, respectively. Mortality rates in decreasing order were RHE, INF and MLG groups, respectively. As an interaction was found between gender and survival, results of survival analysis were given as stratified according to gender. While there was no survival difference between RHE and INF groups among men, both of these groups had better survival than MLG group (ROM-INF p=0.13; ROM-MLG p=0,001; INF-MLG p=0,022). Among women, only there was a significant survival difference between RHE and MLG groups (ROM-INF p=0.15; ROM-MLG p=0,007; INF-MLG p=0,42). <h3>Conclusion</h3> Among patients evaluated for FUO, survival rate was higher in patients who had a rheumatological diagnosis. Further diagnostic algorithms are needed to identify these subgroups, because of the higher mortality among INF and MLG groups. <h3>References</h3> [1] Knockaert DC, Dujardin KS, Bobbaers HJ. Long-term follow-up of patients with undiagnosed fever of unknown origin. Arch Intern Med. 1996;156(6):618. <h3>Disclosure of Interests</h3> Emre Bilgin: None declared, Berkan Armagan: None declared, Alper Sarı: None declared, Ertuğrul Çağrı Bölek: None declared, Bayram Farisoğulları: None declared, Gözde Kübra Yardımcı: None declared, Levent Kılıç: None declared, Ali Akdoğan: None declared, Omer Karadag: None declared, Şule Apraş Bilgen: None declared, Ali İhsan Ertenli: None declared, Sedat Kiraz: None declared, Umut Kalyoncu Grant/research support from: MSD, Roche, UCB, Novartis and Pfizer, Consultant for: MSD, Abbvie, Roche, UCB, Novartis, Pfizer and Abdi Ibrahim, Speakers bureau: MSD, Abbvie, Roche, UCB, Novartis, Pfizer and Abdi Ibrahim