AB1041 PREVALENCE OF JUVENILE IDIOPATHIC ARTHRITIS (JIA) SUBGROUPS AND JIA-ASSOCIATED UVEITIS AMONG JIA PATIENTS ADMITTED TO REFERRAL PEDIATRIC RHEUMATOLOGY CLINICS IN TURKEY: A RETROSPECTIVE STUDY, JUPITER
Authors: Sezgin Sahin, Ceyhun Acarı, Hafize Emine Sonmez, Fatma Zehra Kilic, Erdal Sag, Hatice Adiguzel Dundar, Amra Adrovic, Selcan Demir, Kenan Barut, Yelda Bilginer, Betül Sözeri, Erbil Unsal, Seza özen, Ozgur Kasapcopur
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> Juvenile Idiopathic Arthritis (JIA) is a chronic childhood arthritis with onset before age of 16 and has a significant degree of morbidity that negatively affects quality of life. Uveitis, which is defined as the inflammation of the iris, ciliary body and choroid, is the most common cause of morbidity of JIA. This study was planned to collect data from a Turkish cohort to provide the initial national prevalence data of patients with JIA. <h3>Objectives</h3> The objective of this study was to determine the frequency of JIA subtypes in Turkey. We also aimed to assess the frequency and characteristics of eye involvement in JIA. <h3>Methods</h3> This national, non-interventional, multicenter, observational study was conducted in a retrospective manner in four study centers which were main referral pediatric rheumatology clinics across Turkey. Data on patient demography, medical history, JIA disease characteristics, laboratory data, cases of JIA-associated uveitis, JIA treatment history and data on other comorbidities were collected from a cohort of 500 patients. <h3>Results</h3> Oligoarthritis (n=194, 38.8%) was the most common JIA disease characteristic in this study cohort. The frequency of the subgroups was as follows: Enthesitis-Related Arthritis (ERA) in 23.2% (n=116), polyarthritis in 15.6% (n=78), systemic arthritis in 12.2% (n=61), psoriatic arthritis in 5.2% (n=26), idiopathic arthritis in 2.8% (n=14) and polyarthritis (RF+) in 2.2% (n=11) of patients were identified. The most frequently prescribed treatment for JIA was methotrexate (n=384, 76.8%). A total of 85 comorbidities were reported, and the most frequently reported comorbidity was Familial Mediterranean Fever (FMF) (n=63, 12.6%). The number of patients with JIA-associated uveitis diagnosis was 34 (6.8%), and the mean duration of uveitis was 3.2 (±2.3) years. The mean duration between the initial JIA diagnosis and diagnosis of uveitis was 1.8 (±1.9) years. Among 34 patients with uveitis, 45 eye involvements were identified; left eye, right eye and both eyes were affected in 5, 8 and 16 patients, respectively. Five patients (14.7%) had uveitis-related complications that required surgical intervention. <h3>Conclusion</h3> The main difference from the European Caucasian population is the lower frequency of oligoarticular JIA and higher frequency of ERA in Turkish JIA patients. Uveitis was also somewhat lower than expected. Geographic and ethnic factors, that may affect these differences, need further investigation. <h3>References</h3> [1] Barut K, Adrovic A, Şahin S and KasapÇopur ö. Juvenile Idiopathic Arthritis. Balkan Med J. 2017;34:90-101. [2] Demirkaya E, Ozen S, Bilginer Y, et al. The distribution of juvenile idiopathic arthritis in the eastern Mediterranean: results from the registry of the Turkish Paediatric Rheumatology Association. Clin Exp Rheumatol. 2011;29:111-6 <h3>Acknowledgement</h3> This JUPITER study is a collaborative study. <h3>Disclosure of Interests</h3> Sezgin Sahin: None declared, Ceyhun Acarı: None declared, Hafize Emine Sonmez: None declared, Fatma Zehra Kilic: None declared, Erdal Sag: None declared, Hatice Adiguzel Dundar: None declared, Amra Adrovic: None declared, Selcan Demir: None declared, Kenan Barut: None declared, Yelda Bilginer: None declared, Betül Sözeri: None declared, Erbil Unsal Grant/research support from: Novartis, AbbVie, Roche, KoÇak Pharma, Speakers bureau: Novartis, AbbVie, Roche, KoÇak Pharma, Seza özen Consultant for: Seza Ozen is receiving consultancy fees from Novartis, Speakers bureau: Roche, Ozgur Kasapcopur: None declared