tbuckley/cabot-search huggingface dataset:
Abstract P6-13-07: Cost-effective care for newly diagnosed breast cancer patients: Think globally, act locally
Authors: Annie Tang, Shannon Ugarte, Rohan John, Amal Khoury, Kevin Knopf
Journal: Cancer Research (2020)

Abstract Conscientious use of scarce health economic resources allows for social distributive justice by avoiding over-treatment of patients to allow for appropriate treatment for a broader patient population. Lower socioeconomic status patients with breast cancer have a worse outcome compared to higher socioeconomic status patients in the United States. In part, this is due to poor access to medical care and a failure of logistical care. We implemented a community based breast cancer multidisciplinary program with weekly meetings to discuss patients, coordinate care, and provide cost-effective care to a medically under-served and vulnerable patient population. Breast surgery and medical oncology providers saw patients together in a co-located space and expedited timely initiation of neoadjuvant and adjuvant chemotherapy / hormone therapy for appropriate patients. The conjoint clinic allowed for rapid temporal integration of care in our safety net hospital / community. A single breast cancer navigator provided rapid identification of patients, coordination through clinics, and assistance with social work and other needs. Weekly 30 minute discussion sessions reviewing all new and relevant follow up patient issues were implemented in lieu of a breast cancer tumor board for efficiency. The relevant published clinical literature was reviewed on an ongoing basis. Cost-effective care was obtained by implementing: 1) avoidance of post lumpectomy radiation for selected patients based on PRIME2 trial results, 2) judicious use of post-mastectomy radiation based on a careful re-analysis of the data, 3) avoidance of adjuvant/neoadjuvant Perjeta in HER2+ patients based on a lack of overall survival, 4) adoption of 6 month schedule of adjuvant Herceptin, 5) avoidance of excessive imaging by following NCCN guidelines and clinical judgment, 6) limiting dose dense chemotherapy to appropriate patients (ER- high risk node negative or node positive), and 7) No Nernyx. Using a cost-effectiveness analysis methodology, we are reviewing costs, effectiveness of interventions, and risks with outcomes measured from side effects, complications, recurrence, and mortality. The improvement in temporal parameters and economic endpoints are being currently monitored retrospectively and prospectively and will be presented. Citation Format: Annie Tang, Shannon Ugarte, Rohan John, Amal Khoury, Kevin Knopf. Cost-effective care for newly diagnosed breast cancer patients: Think globally, act locally [abstract]. In: Proceedings of the 2019 San Antonio Breast Cancer Symposium; 2019 Dec 10-14; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(4 Suppl):Abstract nr P6-13-07.
Author Correction: 547 transcriptomes from 44 brain areas reveal features of the aging brain in non-human primates
Authors: Ming-Li Li, Shi-Hao Wu, Jin-Jin Zhang, Hang-Yu Tian, Yong Shao, Zheng-Bo Wang, David M. Irwin, Jia-Li Li, Xin-Tian Hu, Dong-Dong Wu
Journal: Genome biology (2020)

Following publication of the original paper [1], the authors reported an error in the affiliation of Xin-Tian Hu, who is also affiliated with "Kunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China".
BMP9/10 in Pulmonary Vascular Complications of Liver Disease
Authors: Elizabeth R. Rochon, Michael J. Krowka, Sonja Bartolome, Gustavo A. Heresi, Todd Bull, Kari Roberts, Anna Hemnes, Kimberly A. Forde, Karen L. Krok, Mamta Patel, Grace Lin, Megan McNeil, Nadine Al-Naamani, Beth L. Roman, Paul B. Yu, Michael B. Fallon, Mark T. Gladwin, Steven M. Kawut
Journal: American Journal of Respiratory and Critical Care Medicine (2020)
Single-session bridge-to-surgery choledochoduodenostomy and duodenal stenting in patient with malignant biliary and duodenal obstruction
Authors: Mauro Manno, Filippo Scopelliti, Tommaso Gabbani, Simona Deiana, Laura Ottaviani, Sara Vavassori, Paola Soriani
Journal: Endoscopy (2020)

Endoscopic ultrasound (EUS)-guided biliary drainage using lumen-apposing metal stent (LAMS) is considered an effective alternative approach when endoscopic retrograde cholangiopancreatography fails in patients with malignant obstructive jaundice. Duodenal neoplastic stenosis may coexist and patient management becomes challenging. Sequential placement of biliary and duodenal stents has been described previously in patients with unresectable pancreatic cancer [1].
Leukocytosis in Polycythemia Vera and Splenomegaly in Essential Thrombocythemia Are Independent Risk Factors of Hemorrhage
Authors: Y. Chou, J. Gau, J. Liu, Y. Yu, J. Pai, L. Hsiao, Y. Hong, C. Liu, P. Chen, C. Tzeng
Journal: Annals of Oncology (2012)
Microstructural Bone Changes Are Associated With <scp>Broad‐Spectrum</scp> Autoimmunity and Predict the Onset of Rheumatoid Arthritis
Authors: David Simon, Arnd Kleyer, Duy Bui Cong, Axel Hueber, Holger Bang, Andreas Ramming, Juergen Rech, Georg Schett
Journal: Arthritis & Rheumatology (2020)

To assess if microstructural bone lesions in individuals at risk of developing rheumatoid arthritis (RA) are related to the spectrum of anti-modified protein antibodies (AMPAs) and affect the risk of developing RA.Cortical microchannels as well as cortical and trabecular bone mineral density (BMD) volumes (expressed as mg hydroxyapatite/cm3 ) were analyzed by high-resolution peripheral quantitative computed tomography of the hand joints of individuals at risk of RA. AMPA response was profiled, including reactivities against citrullinated proteins (vimentin, enolase, and fibrinogen) as well as carbamylated and acetylated vimentin. All subjects were followed up for the development of RA.Subjects at risk of developing RA (n = 75) who had broad-spectrum AMPAs (6-8 reactivities) had significantly more severe microstructural changes, including a higher mean ± SD number of cortical microchannels per joint (95 ± 3) and lower total volumetric BMD (vBMD; 265 ± 45), trabecular vBMD (176 ± 42), and cortical vBMD (585 ± 138), than those with moderate AMPA reactivity (3-5 reactivities) (number of cortical microchannels, 79 ± 30; total vBMD, 293 ± 33; trabecular vBMD, 195 ± 32; and cortical vBMD, 627 ± 91) and those with narrow AMPA reactivity (1-2 reactivities) (number of cortical microchannels, 47 ± 20; total vBMD, 311 ± 34; trabecular vBMD, 211 ± 30; and cortical vBMD, 674 ± 56). Progressors to RA had significantly higher numbers of cortical microchannels (103 ± 30 versus 71 ± 35) and lower bone volume (258 ± 37 versus 295 ± 34) compared to nonprogressors. Furthermore, rate of progression to RA was high in subjects with broad AMPA reactivity (48%) versus those with medium AMPA reactivity (26%) or narrow AMPA reactivity (0%), as well as in those with a high number of cortical microchannels (44%) versus those with a low number of cortical microchannels (10%).Microstructural changes in individuals at risk of RA are associated with broad-spectrum autoimmunity and predict the onset of RA. These data support the concept of structural priming of joints by autoimmunity before the onset of the inflammatory phase of the disease.
Airway Occlusion Pressure As an Estimate of Respiratory Drive and Inspiratory Effort during Assisted Ventilation
Authors: Irene Telias, Detajin Junhasavasdikul, Nuttapol Rittayamai, Lise Piquilloud, Lu Chen, Niall D. Ferguson, Ewan C. Goligher, Laurent Brochard
Journal: American Journal of Respiratory and Critical Care Medicine (2020)

Rationale: Monitoring and controlling respiratory drive and effort may help to minimize lung and diaphragm injury. Airway occlusion pressure (P0.1) is a noninvasive measure of respiratory drive.Objectives: To determine 1) the validity of "ventilator" P0.1 (P0.1vent) displayed on the screen as a measure of drive, 2) the ability of P0.1 to detect potentially injurious levels of effort, and 3) how P0.1vent displayed by different ventilators compares to a "reference" P0.1 (P0.1ref) measured from airway pressure recording during an occlusion.Methods: Analysis of three studies in patients, one in healthy subjects, under assisted ventilation, and a bench study with six ventilators. P0.1vent was validated against measures of drive (electrical activity of the diaphragm and muscular pressure over time) and P0.1ref. Performance of P0.1ref and P0.1vent to detect predefined potentially injurious effort was tested using derivation and validation datasets using esophageal pressure-time product as the reference standard.Measurements and Main Results: P0.1vent correlated well with measures of drive and with the esophageal pressure-time product (within-subjects R2 = 0.8). P0.1ref >3.5 cm H2O was 80% sensitive and 77% specific for detecting high effort (≥200 cm H2O ⋅ s ⋅ min-1); P0.1ref ≤1.0 cm H2O was 100% sensitive and 92% specific for low effort (≤50 cm H2O ⋅ s ⋅ min-1). The area under the receiver operating characteristics curve for P0.1vent to detect potentially high and low effort were 0.81 and 0.92, respectively. Bench experiments showed a low mean bias for P0.1vent compared with P0.1ref for most ventilators but precision varied; in patients, precision was lower. Ventilators estimating P0.1vent without occlusions could underestimate P0.1ref.Conclusions: P0.1 is a reliable bedside tool to assess respiratory drive and detect potentially injurious inspiratory effort.
circRIP2 accelerates bladder cancer progression via miR-1305/Tgf-β2/smad3 pathway
Authors: Yinjie Su, Weilian Feng, Juanyi Shi, Luping Chen, Jian Huang, Tianxin Lin
Journal: Molecular Cancer (2020)

Abstract Background Increasing evidences indicate that circular RNAs exert critical function in regulating bladder cancer progression. However, the expressive patterns and roles of circular RNAs in bladder cancer remain less investigated. Methods circRIP2 was identified and evaluated by RNA-sequencing and qPCR; in vitro effects of circRIP2 were determined by CCK8, clone forming, wound healing and trans-well assays; while mice subcutaneous tumor model was designed for in vivo analysis. Western blot, RNA pulldown assay, miRNA capture and dual luciferase assessment were applied for mechanistic studies. Results circRIP2 was identified as a conserved and dramatically repressed circular RNA in bladder cancer. Patients that displayed higher circRIP2 expression negatively associate with the grade, stage, metastasis as well as outcome of bladder cancer. In vitro and in vivo studies suggest that circRIP2 enables to promote bladder cancer progression via inducing EMT. Regarding the mechanism, we performed RNA-sequencing analysis, RNA pulldown with biotin-labeled circRIP2-specific probe, dual luciferase reporter assay. It was found that circRIP2 enables to sponge miR-1305 to elevate Tgf-β2 in bladder cancer, and inducing EMT via Tgf-β2/smad3 pathway. Blocking Tgf-β2 in bladder cancer deprives circRIP2 induced cancer progression and EMT. Conclusions Taken together, our study provides the first evidence that circRIP2 expresses differentially in bladder cancer and negatively along with the cancer progression; effective circRIP2 activity accelerates bladder cancer progression via inducing EMT by activating miR-1305/Tgf-β2/smad3 pathway. The research implies that circRIP2 might be a potential biomarker and therapeutic target for bladder cancer patients.
CMI readers' survey 2019
Authors: L. Leibovici, R. Pereira-Moreira
Journal: Clinical Microbiology and Infection (2020)

In 2019, 1173 people participated in the CMI readers' survey. They were based in 95 countries, with 316 responders (27%) in non-European countries. We cannot be sure that this is a fair representation of our readers, but it is a group involved in and caring enough about CMI to participate in the survey. Their opinions matter to us. We compared the responses to a similar CMI readers' survey we conducted in 2016 [1].
Abstract 14960: Development of a 30-Day Angina Risk Standardization Model Following an Acute Myocardial Infarction
Authors: Faraz Kureshi, Suzanne V Arnold, Yan Li, Frederick A Masoudi, Philip G Jones, Sharon Cresci, Thomas M Maddox, Michael Ho, John A Spertus
Journal: Circulation (2013)

Introduction: The substantial economic burden and morbidity associated with angina following myocardial infarction (MI) make it an ideal target for performance measurement to expand quality improve...
Genotype correlates with the natural history of severe bile salt export pump deficiency
Authors: Daan B.E. van Wessel, Richard J. Thompson, Emmanuel Gonzales, Irena Jankowska, Etienne Sokal, Tassos Grammatikopoulos, Agustina Kadaristiana, Emmanuel Jacquemin, Anne Spraul, Patryk Lipiński, Piotr Czubkowski, Nathalie Rock, Mohammad Shagrani, Dieter Broering, Talal Algoufi, Nejat Mazhar, Emanuele Nicastro, Deirdre A. Kelly, Gabriella Nebbia, Henrik Arnell, None Björn Fischler, Jan B.F. Hulscher, Daniele Serranti, Cigdem Arikan, Esra Polat, Dominique Debray, Florence Lacaille, Cristina Goncalves, Loreto Hierro, Gema Muñoz Bartolo, Yael Mozer-Glassberg, Amer Azaz, Jernej Brecelj, Antal Dezsőfi, Pier Luigi Calvo, Enke Grabhorn, Ekkehard Sturm, Wendy J. van der Woerd, Binita M. Kamath, Jian-She Wang, Liting Li, Özlem Durmaz, Zerrin Onal, Ton M.G. Bunt, Bettina E. Hansen, Henkjan J. Verkade
Journal: Journal of Hepatology (2020)
A Phase 2 Study of Multi Oral Immunotherapy in Multi Food Allergic Patients to Test Immune Markers after Minimum Maintenance Dose using Xolair
Authors: Sayantani Sindher, Divya Kumar, Natasha Purington, Dana Tupa, Andrew Long, Shu Cao, Margaret Woch, Tiffany Tan, Maria Garcia Lloret, Sharon Chinthrajah, Kari Nadeau
Journal: Journal of Allergy and Clinical Immunology (2020)
Feasibility of Subcutaneous IgPro20 Administration via Manual Push at High Flow Rates in Patients with Primary Immunodeficiency: Findings of the HILO Study
Authors: Juthaporn Cowan, Vincent Bonagura, Chengping Hu, Patricia Lugar, Paul Maglione, Niraj Patel, Donald VINH, Jutta Hofmann, Mikhail Rojavin
Journal: Journal of Allergy and Clinical Immunology (2020)
肥胖、BMI、吸烟和饮酒作为银屑病关节炎风险因素的研究
Authors: A. Green, G. Shaddick, R. Charlton, J. Snowball, A. Nightingale, C. Smith, W. Tillett, N. McHugh
Journal: British Journal of Dermatology (2020)

银屑病性关节炎 (PsA) 是一种进行性且通常具有破坏性的关节疾病,影响约 20% 的银屑病患者。PsA 引起疼痛、肿胀和关节僵硬,并伴有慢性皮肤病,并可能导致生活质量下降。 了解发生 PsA 的风险因素有所帮助。这项英国研究的目的是研究银屑病患者中肥胖、体重指数 (BMI) 变化、饮酒、吸烟状态和 PsA 的发生之间的关联。从匿名医疗记录中收集数据并进行分析。 作者发现,发生 PsA 的风险增加与 BMI 升高、中度饮酒和曾经戒烟状态有关。此外,与 10 年期间 BMI 保持不变相比,在 10 年期间减少 BMI 与发生 PsA 的风险降低相关。 综上所述,虽然还需要更多的研究来调查有意的体重减轻对发生 PsA 风险的影响,但在肥胖的银屑病患者中,体重减轻可能具有预防他们过度 PsA 风险的潜在作用,同时提供额外的健康益处,包括降低心血管和死亡风险。 本摘要涉及研究: 银屑病患者中可改变风险因素和银屑病关节炎的发生
Deep learning using preoperative MRI information to predict early recovery of urinary continence after robot-assisted radical prostatectomy.
Authors: Makoto Sumitomo, Atsushi Teramoto, Naohiko Fukami, Kosuke Fukaya, Kenji Zennami, Manabu Ichino, Kiyoshi Takahara, Mamoru Kusaka, Ryoichi Shiroki
Journal: Journal of Clinical Oncology (2020)

310 Background: Urinary incontinence remains one of the most bothersome postoperative complications even after robot-assisted radical prostatectomy (RARP). We aimed to make a novel prediction system that can be used preoperatively to inform patients of the accuracy of early recovery of urinary continence after RARP using a deep learning (DL) model from magnetic resonance imaging (MRI) information and preoperative clinicopathological parameters. Methods: A retrospective cohort study was conducted on prostate cancer (PC) patients who had undergone RARP at our hospital between August 2015 and July 2019. Patients using no pads/no leakage of urine or the use of a safety pad within 3 months after RARP is categorized into “good” continence and others into “no good” continence. MRI DICOM data from axial, coronal and sagittal imaging as well as preoperative clinicopathological covariates (age, BMI, prostate volume, serum PSA level, Gleason score, clinical stage) were assessed. Supervised DL algorithms, which included AdaBoost, Naive Bayes, Neural Network, Random Forest, and SVM were trained and tested as binary classifiers (good or no good). To evaluate the DL models from the testing data set, their sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV), as well as area under the receiver operating characteristic curve (AUC) were analyzed. Results: Data were available for 497 patients in the study period. The AdaBoost DL algorithm using MRI information in addition to clinicopathological parameters had the highest performance with sensitivity at 92%, specificity at 77%, PPV at 79%, NPV at 91%, and AUC at 84% for predicting good continence, while that using clinicopathological parameters only had the performance with sensitivity at 50%, specificity at 69%, PPV at 60%, NPV at 60%, and AUC at 60%. Conclusions: Our results suggest that the DL algorithms using MRI imaging information are highlighted as an accurate method for strongly predicting early recovery of urinary continence after RARP. Thus, DL predictions may help allocation of treatment strategies for PC patients who dislike prolonged urinary incontinence after RARP.
Associations Between Race/Ethnicity and US Childhood and Adolescent Cancer Survival by Treatment Amenability
Authors: Arash Delavar, Justin M. Barnes, Xiaoyan Wang, Kimberly J. Johnson
Journal: JAMA Pediatrics (2020)

<h3>Importance</h3> Although US cancer survival rates have increased over time, disparities by race/ethnicity remain, including for children and adolescents. <h3>Objective</h3> To examine whether racial/ethnic disparities in childhood and adolescent cancer survival vary by cancer type according to relative survival rates (RSRs), a marker for amenability to medical intervention. <h3>Design, Setting, and Participants</h3> In a retrospective cohort study using US Surveillance, Epidemiology, and End Results data, 67 061 children and adolescents diagnosed at ages 0 to 19 years with a first primary malignant cancer from January 1, 2000, to December 31, 2016, were evaluated. Data analysis was performed from June 19 to November 3, 2019. Participants were followed up from the dates of diagnosis to cancer death or the end of the follow-up period, whichever came first. <h3>Exposures</h3> Race/ethnicity defined as non-Hispanic white, non-Hispanic black, non-Hispanic American Indian/Alaskan Native, non-Hispanic Asian or Pacific Islander, or Hispanic (any race). <h3>Main Outcomes and Measures</h3> Cancer amenability was defined using 5-year RSRs for 103 cancer types. Cox proportional hazards regression was used to compute adjusted hazard ratios (aHRs) and 95% CIs for the association between race/ethnicity and cancer survival for high (&gt;85% RSR), medium (70%-85% RSR), and low (&lt;70% RSR) amenability categories. <h3>Results</h3> Among 67 061 cancer cases, 36 064 were male (53.8%); most individuals were non-Hispanic white (35 186 [52.5%]) followed by Hispanic of any race (19 220 [28.7%]), non-Hispanic black (7100 [10.6%]), non-Hispanic Asian or Pacific Islander (4981 [7.4%]), and non-Hispanic American Indian/Alaskan Native (574 [0.9%]). Mean (SD) age at diagnosis was 9.66 (6.41) years. Compared with non-Hispanic white children and adolescents, a higher aHR of death was observed for high- than low-amenability cancers for non-Hispanic black patients (high: aHR, 1.59; 95% CI, 1.41-1.80 vs low: aHR, 1.35; 95% CI, 1.24-1.47;<i>P</i> = .002 for interaction) and Hispanic (any race) patients (high: aHR, 1.63; 95% CI, 1.50-1.78 vs low: aHR, 1.16; 95% CI, 1.08-1.25;<i>P</i> &lt; .001 for interaction). Results for other race/ethnicities showed similar patterns but were not statistically significant. <h3>Conclusions and Relevance</h3> Racial/ethnic minority children and adolescents were observed to have a higher risk of death than non-Hispanic white children and adolescents, with more amenable cancers having larger relative survival differences. This disparity may be associated with a combination of factors, including differences in access to health care resources.
Association of Take-Home Naloxone and Opioid Overdose Reversals Performed by Patients in an Opioid Treatment Program
Authors: Joanna G. Katzman, Mikiko Y. Takeda, Nina Greenberg, Monica Moya Balasch, Amal Alchbli, William G. Katzman, Julie G. Salvador, Snehal R. Bhatt
Journal: JAMA Network Open (2020)

<h3>Importance</h3> The US opioid crisis was deemed a public health emergency in 2017. More than 130 individuals in the US die daily as a result of unintentional opioid overdose deaths. <h3>Objective</h3> To measure use of take-home naloxone for overdose reversals performed by study participants with opioid use disorder receiving treatment at an opioid treatment program. <h3>Design, Setting, and Participants</h3> In a year-long cohort study, between April 4, 2016, and May 16, 2017, 395 study participants enrolled at the University of New Mexico Addiction and Substance Abuse Opioid Treatment Program, an outpatient clinic treating substance use disorders. Inclusion criteria included all patients enrolled at University of New Mexico Addiction and Substance Abuse Opioid Treatment Program during the study enrollment period; positive history of opioid use disorder treated with methadone, buprenorphine, or naltrexone; and age 18 years or older. Exclusion criteria included allergy to naloxone and age younger than 18 years. The study closed 1 year after enrollment, on May 17, 2018. Data analysis was performed from May 2018 to July 2019. <h3>Exposure</h3> Two doses of take-home naloxone combined with opioid overdose education were provided to study participants. <h3>Main Outcomes and Measures</h3> The primary outcome was to measure the association of take-home naloxone with overdose reversals performed by patients with opioid use disorder enrolled in an opioid treatment program. <h3>Results</h3> We enrolled 395 study participants (270 female [68.4%]; mean [SD] age, 35.4 [12.6] years; 260 [65.8%] with Hispanic white race/ethnicity) in the 1-year prospective trial. Sixty-eight female participants (25.2% of all female participants) were pregnant at the time of enrollment. Seventy-three of the 395 study participants (18.0%) performed 114 overdose reversals in the community. All community reversals were heroin related. Most study participants (86.8%) stated that the person on whom they performed an overdose reversal was a friend, relative, acquaintance, or significant other. In the year before enrollment, only 18 study participants (4.5%) had been prescribed naloxone. <h3>Conclusions and Relevance</h3> Take-home naloxone as part of overdose education and naloxone distribution provided to patients in an opioid treatment program may be associated with a strategic targeted harm reduction response for reversing opioid overdose–related deaths. Policy makers may consider regulations to mandate overdose education and naloxone distribution in opioid treatment programs.
Angiosarcoma Involving the Heart
Authors: Aju P Pazhenkottil, Peter K Bode
Journal: New England Journal of Medicine (2020)

A 66-year-old man presented to the emergency department with a 4-day history of shortness of breath and swelling in the legs.He also reported feeling fatigued and having had a recent 15-kg weight loss.A transthoracic echocardiogram showed a mass in the right atrium that appeared to be infiltrating the pericardium.This mass was also visualized on computed tomography of the chest (Panel A).No evidence of metastatic lesions was found on 18 F-fluorodeoxyglucose positron-emission tomography.Examination of a biopsy specimen from the lesion revealed high-grade angiosarcoma.Tumor-debulking surgery was performed, and adjuvant chemotherapy was planned; however, hemodynamic instability developed, and despite receiving maximal supportive therapy, the patient died in the intensive care unit.An autopsy was performed, and gross pathological examination of the heart revealed extensive infiltration of the tumor into the epicardium (Panel B).