tbuckley/cabot-search huggingface dataset:
Abstract 18863: Poorer Attention in Heart Failure is Related to Increased Attentional Demands and Oxygen Saturation
Authors: Miyeon Jung, John Jonides, Laurel Northouse, Marc G Berman, Todd M Koelling, Janet L Larson, Susan J Pressler
Journal: Circulation (2015)

Introduction: Attention is critical to performing self-care and is impaired in 25% of patients with heart failure (HF). Although HF patients may have greater attentional demands from their chronic condition, reasons for their impaired attention have included altered oxygenation to the brain, but not mental effort. Purpose: To compare attention between HF patients and age-matched healthy adults and examine relationships between attention and mental effort, blood pressure (BP), and oxygen saturation (SpO2). Methods: Baseline data were included from 40 participants (20 HF, 20 healthy) enrolled in a cognitive intervention study. Attention was measured using 4 neuropsychological tests (Multi-Source Inference Task (MSIT), Stroop, Trail Making (TMT), Digit Span Tests) and perceived attention by Attentional Function Index (AFI). Mental effort for chronic disease was measured by a self-report questionnaire. BP and SpO2 were measured during testing. Descriptive statistics, t-tests, X2 tests, and Pearson correlations were conducted. Significance level was .05. Results: Demographics were similar for HF and healthy groups (age = 60 vs 59 yrs, education = 15 yrs for both). Mean LVEF was 37% and NYHA class was 2.5 in HF patients. Compared with healthy adults, HF patients performed poorer on 3 tests of attention. On TMT, HF patients took 40% longer to complete test A (41 vs 27, p = .001) and B (100 vs 60 sec, p = .002). Similarly, HF patients had slower responses and more errors on MSIT and Stroop test (p = .007 - .045). Patients with HF scored lower in AFI than healthy adults (p &lt; .001). Compared with healthy adults, HF patients had greater mental effort (p = .014), lower BP (110/66 vs 124/74mmHg) and SpO2 (96.6 vs 97.6%). Greater mental effort was related to slower responses on TMT-A and MSIT, more errors on MSIT and Stroop test, and poorer AFI (p = &lt;.001 - .048). Lower SpO2 was related to poorer attention on TMT-B and AFI. More time with SpO2 &lt; 95% was related to poorer attention on TMT-B, MSIT, and AFI. Conclusions: Patients with HF had poorer attention than healthy adults. Poorer attention was associated with increased mental effort and lower oxygen saturation. Future studies are needed to improve attention and to evaluate if improving oxygen and mental effort improve attention in larger samples.
Performance of a new preloaded fiducial needle to guide radiation therapy of upper gastrointestinal cancers
Authors: Vinh-An Phan, Raymond Dalfsen, Hien Le, Nam Q. Nguyen
Journal: Endoscopy (2018)

Abstract Background Insertion of fiducials to outline the targeted lesion allows image-guided radiotherapy, and is best achieved by endoscopic ultrasound (EUS). This study is a performance comparison of the new EUS-guided preloaded fiducial needle against Visicoil fiducials. Methods Technical success, visibility score, procedural time, costs, and complications for patients who underwent EUS-guided fiducial placement in upper gastrointestinal malignancies were prospectively collected. Results 60 patients with upper gastrointestinal cancers had fiducials (14 Visicoil; 46 preloaded fiducials) inserted for image-guided radiotherapy. Technical success was 100 %, with a shorter mean (standard deviation) insertion time of 0.94 minutes (0.28 minutes) vs. 5.5 minutes (1.9 minutes; P &lt; 0.001) and higher visibility score on fluoroscopy of 2 vs. 1.18 (P &lt; 0.001) in the preloaded group. Neither group had major complications related to fiducial insertion. The cost of consumables per patient was lower in the preloaded group at US$480 (US$124) vs. US$643 (US$123; P &lt; 0.001). Conclusion Fiducial insertion for image-guided radiotherapy using the new preloaded needle is associated with 100 % technical success, shorter insertion time, and higher visibility, and is more cost-effective than the Visicoil system.
Perioperative Anticoagulant Use for Surgery Evaluation (PAUSE) Study: A Perioperative Management Plan for Patients with Atrial Fibrillation Who Are Receiving a Direct Oral Anticoagulant
Authors: James Douketis, Alex C. Spyropoulos, Joanne M Duncan, Marc Carrier, Gregoire Le Gal, Alfonso J Tafur, Thomas Vanassche, Peter Verhamme, Sudeep P Shivakumar, Peter L. Gross, Agnes Yuet Ying Lee, Erik Yeo, Susan Solymoss, Jeannine Kassis, Genevieve Le Templier, Stephen Kowalski, Mark Blostein, Vinay Shah, Elizabeth MacKay, Cynthia M. Wu, Nathan Clark, Shannon M. Bates, Fred Spencer, Eleni Arnaoutoglou, Michiel Coppens, Donald M. Arnold, Joseph A Caprini, Na Li, Karen Moffat, Syed Summer, Sam Schulman
Journal: Blood (2018)
Prevalence of pathogenic/likely pathogenic variants in the 24 cancer genes of the ACMG Secondary Findings v2.0 list in a large cancer cohort and ethnicity-matched controls
Authors: Jung Kim, Wen Luo, Mingyi Wang, Talia Wegman-Ostrosky, Megan N. Frone, Jennifer J. Johnston, Michael L. Nickerson, Melissa Rotunno, Shengchao A. Li, Maria I. Achatz, Seth A. Brodie, Michael Dean, Kelvin C. de Andrade, Fernanda P. Fortes, Matthew Gianferante, Payal Khincha, Mary L. McMaster, Lisa J. McReynolds, Alexander Pemov, Maisa Pinheiro, Karina M. Santiago, Blanche P. Alter, Neil E. Caporaso, Shahinaz M. Gadalla, Lynn R. Goldin, Mark H. Greene, Jennifer Loud, Xiaohong R. Yang, Neal D. Freedman, Susan M. Gapstur, Mia M. Gaudet, Donato Calista, Paola Ghiorzo, Maria Concetta Fargnoli, Eduardo Nagore, Ketty Peris, Susana Puig, Maria Teresa Landi, Belynda Hicks, Bin Zhu, Jia Liu, Joshua N. Sampson, Stephen J. Chanock, Lisa J. Mirabello, Lindsay M. Morton, Leslie G. Biesecker, Margaret A. Tucker, Sharon A. Savage, Alisa M. Goldstein, Douglas R. Stewart
Journal: Genome Medicine (2018)

Prior research has established that the prevalence of pathogenic/likely pathogenic (P/LP) variants across all of the American College of Medical Genetics (ACMG) Secondary Findings (SF) genes is approximately 0.8–5%. We investigated the prevalence of P/LP variants in the 24 ACMG SF v2.0 cancer genes in a family-based cancer research cohort (n = 1173) and in cancer-free ethnicity-matched controls (n = 982). We used InterVar to classify variants and subsequently conducted a manual review to further examine variants of unknown significance (VUS). In the 24 genes on the ACMG SF v2.0 list associated with a cancer phenotype, we observed 8 P/LP unique variants (8 individuals; 0.8%) in controls and 11 P/LP unique variants (14 individuals; 1.2%) in cases, a non-significant difference. We reviewed 115 VUS. The median estimated per-variant review time required was 30 min; the first variant within a gene took significantly (p = 0.0009) longer to review (median = 60 min) compared with subsequent variants (median = 30 min). The concordance rate was 83.3% for the variants examined by two reviewers. The 115 VUS required database and literature review, a time- and labor-intensive process hampered by the difficulty in interpreting conflicting P/LP determinations. By rigorously investigating the 24 ACMG SF v2.0 cancer genes, our work establishes a benchmark P/LP variant prevalence rate in a familial cancer cohort and controls.
A network of trans-cortical capillaries as mainstay for blood circulation in long bones
Authors: Anika Grüneboom, Ibrahim Hawwari, Daniela Weidner, Stephan Culemann, Sylvia Müller, Sophie Henneberg, Alexandra Brenzel, Simon Merz, Lea Bornemann, Kristina Zec, Manuela Wuelling, Lasse Kling, Mike Hasenberg, Sylvia Voortmann, Stefanie Lang, Wolfgang Baum, Alexandra Ohs, Oliver Kraff, Harald H. Quick, Marcus Jäger, Stefan Landgraeber, Marcel Dudda, Renzo Danuser, Jens V. Stein, Manfred Rohde, Kolja Gelse, Annette I. Garbe, Alexandra Adamczyk, Astrid M. Westendorf, Daniel Hoffmann, Silke Christiansen, Daniel Robert Engel, Andrea Vortkamp, Gerhard Krönke, Martin Herrmann, Thomas Kamradt, Georg Schett, Anja Hasenberg, Matthias Gunzer
Journal: Nature Metabolism (2018)
Association between physical activity and risk of hepatobiliary cancers: A multinational cohort study
Authors: Sebastian E. Baumeister, Sabrina Schlesinger, Krasimira Aleksandrova, Carmen Jochem, Mazda Jenab, Marc J. Gunter, Kim Overvad, Anne Tjønneland, Marie-Christine Boutron-Ruault, Franck Carbonnel, Agnès Fournier, Tilman Kühn, Rudolf Kaaks, Tobias Pischon, Heiner Boeing, Antonia Trichopoulou, Christina Bamia, Carlo La Vecchia, Giovanna Masala, Salvatore Panico, Francesca Fasanelli, Rosario Tumino, Sara Grioni, Bas Bueno de Mesquita, Roel Vermeulen, Anne M. May, Kristin B. Borch, Sunday O. Oyeyemi, Eva Ardanaz, Miguel Rodríguez-Barranco, María Dolores Chirlaque López, Mireia Felez-Nobrega, Emily Sonestedt, Bodil Ohlsson, Oskar Hemmingsson, Mårten Werner, Aurora Perez-Cornago, Pietro Ferrari, Magdalena Stepien, Heinz Freisling, Konstantinos K. Tsilidis, Heather Ward, Elio Riboli, Elisabete Weiderpass, Michael F. Leitzmann
Journal: Journal of Hepatology (2018)
Evaluation of chemotherapy benefit in patients who continue to smoke: Preliminary experience.
Authors: Antonio Jirillo, Paola Rescigno, Magdalena Mazurek, Marta Paulina Trojniak, Antonio di Maggio, Silvia Imbevaro
Journal: Journal of Clinical Oncology (2013)

e12534 Background: The smoking continuation during chemotherapy treatments affects positive results. As reported for instance by Mazza et al. in the review "Taking care of smoker cancer patients: a review and some recommendations" (Ann Oncol. 21(7):1404-9, 2010), nicotin seems to inhibit the potential of cisplatin in determining tumor cell death (Int J Oral Maxillofac Surg 2007; 36: 739–744), while some new anti-cancer drugs can give an excellent response only in people who have never smoked (Proc Natl Acad Sci U S A 2004; 101(36): 13306–13311). Methods: It is an observational monoistitutional analysis. The analysis covered 886 patients undergoing chemotherapy at the Veneto Oncology Institute of Padua during an observation period of six years (from 2006 to 2011). We have been taken into account all patients included in the Onco-AIFA national register for the monitoring of innovative anticancer drugs, focusing on the three big killer diseases: colon and rectum cancer (40% of the sample analyzed), lung cancer (36%) and breast cancer (24%). The Kaplen-Meier method was used to analyze the overall survival data. Results: Among the information collected, the aspect of smoking was taken into account: it was possible to extract the data for about half of the patients (n = 473), 48% of whom were non-smokers, 31% were smokers and the remaining 21% ex-smokers. Although there are three types of cancer that have three different natural histories, the study revealed that being a smoker or ex-smoker is a determinant of the OS of patients: in particular non-smokers showed a median survival of 27 months, ex-smokers of 18 and smokers of 13 (p &lt;0.001). Conclusions: It should be noted then, that in the entirety of the sample smoking continuation reduces survival. Therefore, in addition to an increased risk, there is a reduced benefit in terms of clinical conditions and response since tobacco reduces the effects of anticancer chemotherapy. That being so, although the data are still preliminary, every effort must be made to ensure that a patient stops smoking during chemotherapy treatments as it has been demonstrated that the ex-smokers live an average 6 months longer.
Evaluation of a Standardized Geriatric Assessment at Diagnosis in a Prospective Cohort of Elderly Patients with Newly Diagnosed Acute Myeloid Leukemia
Authors: Colombe Saillard, Frederique Rousseau, Maud Cecile, Cecile Braticevic, Anne Etienne, Jerome Rey, Evelyne D'Incan, Christophe Zemmour, Norbert Vey, Aude Charbonnier
Journal: Blood (2018)
Abstract 16994: Excitation-Contraction Coupling in a Rat Model of Heart Failure With Preserved Ejection Fraction (HFpEF)
Authors: Peter J Kilfoil, Xin Yue, Rui Zhang, Ryan Solymani, Daniel Soetkamp, Eduardo Marbán, Joshua I Goldhaber
Journal: Circulation (2017)

The fundamental characteristics of calcium cycling are poorly characterized in heart failure with preserved ejection fraction (HFpEF). Abnormal diastolic function is the hallmark of HFpEF, but several lines of evidence hint that systolic function is also defective. To characterize excitation-contraction (EC) coupling in HFpEF, we measured L-type Ca current (ICa) and intracellular calcium (Ca) in left ventricular myocytes isolated from Dahl salt-sensitive (DS) rats with phenotypically-verified HFpEF produced by feeding them a high salt diet (8% NaCl). DS rats fed normal salt served as controls (Con). Whole-cell patch clamp revealed a 24% increase in ICa density in HFpEF myocytes depolarized to 0 mV (n=17 Con; n=29 HFpEF; p<0.01) with a leftward shift in the peak voltage, despite a 37% reduction in Cav1.2 protein expression by mass spectroscopy. ICa inactivation kinetics were slowed in HFpEF (τfast: 7.2 ± 0.4 vs. 9.0 ± 0.7, p<0.03; τslow: 59.8 ± 2.8 vs. 86.8 ± 5.8, p<0.001; n=20 Con, n=17 HFpEF). Steady-sta...
42 Depression-associated alterations in the maternal microbiome during pregnancy: priming for adverse infant outcomes?
Authors: KL Togher, AS Khashan, LC Kenny, C Stanton, I Carafa, K Murphy, Gwo Keeffe, CA Ryan, JF Cryan, TG Dinan, G Clarke
Journal: Gut (2017)

Background  Women at high risk of prenatal depressive symptomology have higher rates of adverse obstetric outcomes (1) and altered infant development (2). The mechanisms underpinning this may be linked to inappropriate remodelling of the microbiome during pregnancy and subsequent vertical transmission of a suboptimal microbiome at birth.  Aim  This cross-sectional study aimed to assess the association between the maternal microbiome and depressive symptoms.  Method  Women enrolled in the IMPROvED study at Cork University Maternity Hospital (3) completed the Edinburgh Postnatal Depression Scale (EPDS) and provided faecal samples during the second (n=46) and third trimester (n=33) of pregnancy. Vaginal swabs were collected prior to delivery (n=60). EPDS ≤8 and EPDS ≥9 were used to indicate low and high depressive symptoms respectively. Microbial community structure analysed by 16S rRNA gene sequencing.  Results  Women reporting higher depressive symptoms in second trimester had reduced phylogenetic diversity (p=0.024) and species richness (chao1; p=0.040) of the gut microbiota. There were significant alterations observed at Phyla, Family and Genus level including an increase in the dominant Faecalibacterium (p=0.029) among the higher depressive group. The magnitude of the depression-associated gut alterations was greatly reduced in the third trimester. The vaginal microbiome remained largely unchanged by prenatal depressive symptoms.  Conclusions  The experience of depressive symptoms in mid pregnancy is associated with marked alterations in the maternal gut microbiome that do not persist into late pregnancy. Further studies are planned to clarify the implications of these depression-associated maternal microbiome alterations during pregnancy for obstetric outcomes and infant development.
Abstract 17714: Prevalence of Bicuspid Aortic Valve in 9000 Newborns and Associated Echocardiographic Findings Estimated by Systematic Echocardiographic Screening
Authors: Anne-Sophie Sillesen, Christian A Pihl, Niels G Vejlstrup, Henning Bundgaard, Anna Axelsson, Kasper K Iversen
Journal: Circulation (2017)

Introduction: Bicuspid aortic valve (BAV) is the most common congenital heart defect with necropsy studies estimating a prevalence of 0.5-2 %. Large-scale echocardiographic screening for BAV has no...
Chronic pulmonary aspergillosis commonly complicates treated pulmonary tuberculosis with residual cavitation
Authors: Iain D. Page, Rosemary Byanyima, Sharath Hosmane, Nathan Onyachi, Cyprian Opira, Malcolm Richardson, Richard Sawyer, Anna Sharman, David W. Denning
Journal: European Respiratory Journal (2019)

Chronic pulmonary aspergillosis (CPA) complicates treated pulmonary tuberculosis (TB), with high 5-year mortality. We measured CPA prevalence in this group. 398 Ugandans with treated pulmonary TB underwent clinical assessment, chest radiography and Aspergillus -specific IgG measurement. 285 were resurveyed 2 years later, including computed tomography of the thorax in 73 with suspected CPA. CPA was diagnosed in patients without active TB who had raised Aspergillus- specific IgG, radiological features of CPA and chronic cough or haemoptysis. Author-defined CPA was present in 14 (4.9%, 95% CI 2.8–7.9%) resurvey patients. CPA was significantly more common in those with chest radiography cavitation (26% versus 0.8%; p&lt;0.001), but possibly less frequent in HIV co-infected patients (3% versus 6.7%; p=0.177 ) . The annual rate of new CPA development between surveys was 6.5% in those with chest radiography cavitation and 0.2% in those without (p&lt;0.001). Absence of cavitation and pleural thickening on chest radiography had 100% negative predictive value for CPA. The combination of raised Aspergillus- specific IgG, chronic cough or haemoptysis and chest radiography cavitation had 85.7% sensitivity and 99.6% specificity for CPA diagnosis. CPA commonly complicates treated pulmonary TB with residual chest radiography cavitation. Chest radiography alone can exclude CPA. Addition of serology can diagnose CPA with reasonable accuracy.
Health-related Quality of Life in Nonalcoholic Fatty Liver Disease Associates With Hepatic Inflammation
Authors: Yvonne Huber, Marie Boyle, Kate Hallsworth, Dina Tiniakos, Beate K. Straub, Christian Labenz, Christian Ruckes, Peter R. Galle, Manuel Romero-Gómez, Quentin M. Anstee, Jörn M. Schattenberg
Journal: Clinical Gastroenterology and Hepatology (2018)
Abstract 11301: Lower Systemic Arterial Compliance is Associated With Increased Cardiovascular Morbidity and Mortality in Aortic Valve Stenosis
Authors: Edda Bahlmann, Dana Cramariuc, Mai Tone Lonnebakken, Christa Gohlke-Baerwolf, Terje Pedersen, Christoph A Nienaber, John B Chambers, Karl Heinz Kuck, Eva Gerdts
Journal: Circulation (2016)

Introduction: Systemic arterial compliance (SAC) significantly influences cardiovascular morbidity and mortality in hypertension, but this has not been assessed in a prospective study in aortic stenosis (AS). Hypothesis: Lower SAC is associated with reduced outcome in AS. Methods: Data from 1471 patients (38% women) with initially asymptomatic mild-moderate AS enrolled in the Simvastatin and Ezetimibe in Aortic Stenosis study was used. Median follow-up was 4.3 years. SAC was assessed as the ratio of stroke volume index to central pulse pressure. Results: In multivariable linear regression analysis, lower SAC at baseline was associated with older age, hypertension, obesity, presence of a small aortic root and more severe AS (all p&lt;0.001). In Cox regression analysis, lower SAC (per 1 ml/m 2 /mmHg) was associated with higher hazard rates for major cardiovascular events, aortic valve events, ischemic cardiovascular events and total mortality (all p&lt;0.05), also after adjusting for hypertension, left ventricular mass, AS severity, presence of a small aortic root, randomized study treatment and aortic valve replacement (Table). Conclusion: In AS patients without known cardiovascular disease, but a high prevalence of hypertension, lower SAC is associated with higher morbidity and mortality independent of other well-known prognosticators. Table. The association of lower SAC with cardiovascular events in asymptomatic AS in multivariable Cox analyses.
Abstract 13900: Secretoneurin is an Endogenous CaMKII Inhibitor That Attenuates Ca2+-Dependent Arrhythmogenesis
Authors: Anett Hellebo Ottesen, Cathrine R. Carlson, Derek R. Laver, Peder L. Myhre, Bjørn Dalhus, Per Kristian Lunde, Marianne Lunde, Jon Erik Hoff, Kristin Godang, Mats Stridsberg, Torbjørn Omland, Geir Christensen, Helge Røsjø, William E. Louch
Journal: Circulation (2017)

Introduction: Circulating secretoneurin (SN) levels are reported to predict mortality in patients with myocardial dysfunction. SN has also been observed to inhibit Ca2+/calmodulin-dependent protein...
Abstract 18743: Digoxin and Hospital Readmission in Older Patients With Heart Failure and Reduced Ejection Fraction Receiving Beta Blockers: A Propensity Matched Study of Medicare Linked OPTIMIZE HF
Authors: Ahmed Abdelmawgoud, Sayed Z Qamer, Phillip Lam, Daniel J Dooley, Deedwania Prakash, Javed Butler, Cherinne Arundel, Marc R Blackman, Charity J Morgan, Wilbert S Aronow, Ioannis E Kanonidis, Gregg C Fonarow, Ali Ahmed
Journal: Circulation (2017)

Background: In patients with heart failure (HF), digoxin reduces the risk of 30-day all-cause readmission (PMCID: PMC3929967). In the current study, we examined if digoxin use is associated with lower 30-day all-cause readmission in hospitalized patients with HF and reduced EF (HFrEF) receiving beta-blockers (BBs). Methods: In the Medicare-linked OPTIMIZE-HF registry, of the 10625 hospitalized patients with HFrEF (EF ≤40%), 7601 received a discharge prescription for BBs. We restricted our analysis to an inception cohort of 5307 patients who were not receiving digoxin on admission. Of these, 1075 received a new discharge prescription for digoxin. Propensity scores for digoxin use, estimated for each of the 5307 patients, were used to assemble a cohort of 1043 pairs of patients, receiving and not receiving digoxin, balanced on 46 baseline characteristics. All results are based on 2086 matched patients who had a mean (±SD) age of 75 (±11) years and EF of 25 (±8) percent, 42% were women, and 13% African Ameri...
The Cerebroventricular Environment Reprograms Locally Infused CAR T Cells for Superior Activity Against Both CNS and Systemic B Cell Lymphoma
Authors: Xiuli Wang, Christian Huynh, Ryan Urak, Miriam Walter, Lihong Weng, Laura Lim, Vibhuti Vyas, Brenda Aguilar, Alfonso Brito, Aniee Sarkissian, Achini Bandara, Elizabeth E Budde, Leslie Popplewell, Tanya Siddiqi, Christine Brown, Stephen J Forman
Journal: Blood (2018)
Unintended Harm Associated With the Hospital Readmissions Reduction Program
Authors: Gregg C. Fonarow
Journal: JAMA (2018)

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