tbuckley/cabot-search huggingface dataset:
Clinical and Genetic Profiles of the Aging Sickle Cell Patient.
Authors: Allison E. Ashley-Koch, Laura M. De Castro, Felicia Lennon-Graham, Jude Jonassaint, Terry L. Jackson, Jennifer Price, Jason Galloway, Susan Jones, Eldrida Randall, Charles Packman, Charles Knupp, James R. Eckman, Eugene P. Orringer, Jeffery M. Vance, Marilyn J. Telen
Journal: Blood (2005)
Leukemic Transformation Induces the Constitutive Expression of Indoleamine 2,3-Dyoxigenase Which Directly Increases CD4+CD25+ T Regulatory Cells.
Authors: Antonio Curti, Simona Pandolfi, Michela Aluigi, Barbara Valzasina, Alessandro Isidori, Elisa Ferri, Sergio Rutella, Ilaria Durelli, Alberto L. Horenstein, Francesca Fiore, Massimo Massaia, Milena Piccioli, Emanuela Palmerini, Stefano Pileri, Mario P. Colombo, Michele Baccarani, Roberto M. Lemoli
Journal: Blood (2005)
Dyskeratosis Congenita: Low Regimen-Related Toxicity Following Hematopoietic Cell Transplantation (HCT) Using a Reduced Intensity Conditioning Regimen.
Authors: Jakub Tolar, Paul J. Orchard, Jeffrey S. Miller, Margaret L. MacMillan, John E. Wagner, Blanche P. Alter, K.S. Baker
Journal: Blood (2007)
The Effect of Malignant Neoplasms on the Heart A Study on the Electrocardiographic Abnomalities and the Anatomical Findings in Cases with and without Cardiac Involvement
Authors: Akira Nakamura, Taizan Suchi, Yasushi Mizuno
Journal: Circulation (1975)

Six hundred and twenty-two autopsies of patients with malignant neoplasm were used for this study in order to analyze the incidence of cardiac involvement in relation to the sites of the primary tumor, the anatomical distribution within the heart, and the ECG findings in tumor patients with and without cardiac involvement. Our findings were then discussed in the light of previous reports. 1) The overall incidence of cardiac involvement by malignant tumor was 12.7% (79 outof 622 cases), and the average incidences in carcinomas, sarcomas and the other groups were 1 3.0%, 7.7%, and 17.0%, respectively. Among various carcinomas, breast and pulmonary cancer showed a very high incidence of cardiac involvement, while intestinal and gastric cancer were found to metastasise infrequently to the heart. 2) The incidence of epicardial involvement was very high (65.8%) and that of involvement of the pericardium, myocardium and endocardium was 38.0%, 29. 1% and 19.0%, respectively. 3) No significant difference was observed in the ECG findings recorded between 3 to 6 months, or over 6 months before death between the groups with and without cardiac involvement. 4) A significant difference in the incidence of myocardial damage pattern, arrhythmia and/or intraventricular conduction disturbance (such as ST-T depression, sinus tachycardia or incomplete right bundle branch block) was observed in the ECG recorded within 3 months before death when comparing with the groups with and without cardiac involvement. 5) The cases with metastases to the myocardium were always associated with the pattern of myocardial damage on the ECG.
Abstract #3931: Smoking, green tea consumption, UGT1A1 polymorphism associated with lung cancer risk
Authors: I-Hsin Lin, Ming-Lin Ho, Pei-Yu Chen, You-Rung Chen, Ya-Ru Deng, Yu-Min Tang, Ruey-Hong Wong
Journal: Cancer Research (2009)

Experimental studies have shown that tea preparations and tea polyphenols may inhibit the induction of a variety of cancers, including lung cancer. However, epidemiologic studies on tea consumption and cancer are limited and the results are inconclusive. Tea catechins could be rapidly glucuronidation by human uridine diphosphate glucuronosyltransferases (UGTs). The human UGT1A1 gene is located in chromosome 2q37. A polymorphism (TA)6 to (TA)7 change in the TATA-box of the promoter region of the UGT1A1 gene, and the position 211 of exon 1 of the UGT1A1 gene contains a G to A transition (G71R) have been reported. These structural variations are believed to result in about 30-80 percent reduction in enzymatic activity. Therefore, smokers who drank less green tea might have an elevated risk of lung cancer. Individuals who experienced non-susceptible UGT1A1 genotype and drank greater green tea might have a decreased risk of lung cancer. We designed a hospital-based case-control study to evaluate the effects of smoking, green tea intake, and genetic polymorphism of UGT1A1 on the risk of lung cancer. A total of 136 primary lung cancer patients and 272 individual-matched controls were included. Interviews were administered using the structured questionnaire that covered demographic characteristics and life styles, including smoking habits, green tea consumption, dietary intake of fruits and vegetables, cooking practices and family history of lung cancer. The genotypes for UGT1A1 G71R (Gly71Arg) and TATA box [(TA)6 to (TA)7] were identified by polymerase chain reaction and restriction fragment length polymorphism and short tandem repeat polymorphism. Our result showed that smoking, green tea consumption less than one cup per day, exposure to the fume of cooking and family history of lung cancer were associated with elevated lung cancer risk. After adjusting the effects of the fume of cooking and family history of lung cancer, the relative risks was significantly higher in heavy smokers without green tea drinking, as compared to non-smokers who drank green tea more than one cups per day (odds ratio [OR] = 26.6; 95% C.I. = 6.6-107.1), and in comparison to non-smokers who drank green tea more than ten years (OR = 42.0, 95% C.I.= 7.7-228.3), respectively. Among green tea drinkers, those who carrying the low activity of UGT1A1 G71R R allele were associated with a significantly reduced risk of lung cancer compared with those who carrying the high activity of G71R G allele. Similar result in the lung cancer risk and genotype of UGT1A1 TATA box was observed, although it did not reach a significance. In conclusion, green tea drinkers who carrying low activity of UGT1A1 genotype might metabolize tea polyphenols slowly; and thus experienced a reduced risk of lung cancer caused by smoking.  Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 3931.
Allogeneic transplantation in elderly patients ≥65 years with non-Hodgkin lymphoma: a time-trend analysis
Authors: Nirav N. Shah, Kwang Woo Ahn, Carlos Litovich, Anna Sureda, Mohamed A. Kharfan-Dabaja, Farrukh T. Awan, Siddhartha Ganguly, Usama Gergis, David Inwards, Reem Karmali, Alexsandr Lazaryan, Lazaros Lekakis, Pashna Munshi, Sunita Nathan, Ayman A. Saad, Melhem Solh, Amir Steinberg, Ravi Vij, William A. Wood, Timothy S. Fenske, Sonali Smith, Mehdi Hamadani
Journal: Blood Cancer Journal (2019)

Abstract Allogeneic hematopoietic cell transplantation (allo-HCT) is a curative therapy for relapsed/refractory and high-risk non-Hodgkin lymphoma (NHL). However, no large studies have evaluated allo-HCT utilization in elderly NHL patients (≥65 years). Using the CIBMTR registry, we report a time-trend analysis of 727 NHL patients (≥65 years) undergoing the first allo-HCT from 2000 to 2015 in the United States (US). Study cohorts were divided by time period: 2000–2005 ( N = 76) vs. 2006–2010 ( N = 238) vs. 2011–2015 ( N = 413). Primary outcome was overall survival (OS). Secondary outcomes included progression-free survival (PFS), relapse/progression (R/P), and non-relapse mortality (NRM). Median age at transplant, use of reduced-intensity conditioning, and graft source remained stable, while use of unrelated donors increased in the most current era. The 1-year probabilities of NRM from 2000 to 2005 vs. 2006–2010 vs. 2011–2015 were 24% vs. 19% vs. 21%, respectively ( p = 0.67). Four-year probability of R/P was similar among the three cohorts: 48% (2000–2005), 40% (2006–2010), and 40% (2011–2015) ( p = 0.39). The 4-year probabilities of PFS and OS (2000–2005 vs. 2006–2010 vs. 2011–2015) showed significantly improved outcomes in more recent time periods: 17% vs. 31% vs. 30% ( p = 0.02) and 21% vs. 42% vs. 44% ( p &lt; 0.001), respectively. Utilization of allo-HCT increased in elderly NHL patients in the US since 2000 with improving survival outcomes.
Mutations in the Receptor Tyrosine Kinase Pathway Are Associated with Clinical Outcome in Patients with Acute Myeloblastic Leukemia Harboring t(8;21)(q22;q22).
Authors: Tomoko Nanri, Naofumi Matsuno, Toshiro Kawakita, Hitoshi Suzushima, Fumio Kawano, Hiroaki Mitsuya, Norio Asou
Journal: Blood (2004)
Update: Demographic, Product, and Substance-Use Characteristics of Hospitalized Patients in a Nationwide Outbreak of E-cigarette, or Vaping, Product Use–Associated Lung Injuries — United States, December 2019
Authors: Matthew J. Lozier, Bailey Wallace, Kayla Anderson, Sascha Ellington, Christopher M. Jones, Dale Rose, Grant Baldwin, Brian A. King, Peter Briss, Christina A. Mikosz, Chelsea Austin, Sharyn Brown, Gyan Chandra, Angela Coulliette-Salmond, Kelsey Coy, Dustin Currie, Alissa Cyrus, Melissa Danielson, Geroncio Fajardo, Allison Gately, Sonal Goyal, Sierra Graves, Janet Hamilton, Donald Hayes, Denise Hughes, Mia Israel, Michael Landen, Ruth Lynfield, Suzanne Newton, Rashid Njai, Loria Pollack, Jeff Ratto, Matthew Ritchey, Katherine Roguski, Phillip Salvatore, Stephen Soroka, Elizabeth Swedo, Kimberly Thomas, Stephanie Thomas
Journal: MMWR Morbidity and Mortality Weekly Report (2019)
Implementation of non-communicable disease policies: a geopolitical analysis of 151 countries
Authors: Luke N Allen, Brian D Nicholson, Beatrice Y T Yeung, Francisco Goiana-da-Silva
Journal: The Lancet Global Health (2019)

BackgroundMost countries have endorsed WHO non-communicable disease (NCD) best buy policies, but we know very little about global implementation patterns and about the geopolitical factors affecting implementation. We aimed to assess global implementation based on analysis of multiple geopolitical datasets.MethodsWe used the 2015 and 2017 WHO NCD progress monitor reports to calculate aggregate implementation scores for 151 countries, based on their implementation of 18 WHO-recommended NCD policies. We ranked all countries and used descriptive statistics to analyse global trends. We used linear regression to assess the associations between policy implementation and World Bank geographic region, risk of premature NCD mortality, percentage of all deaths caused by NCDs, World Bank income group, human capital index, democracy index, and tax burden.FindingsIn 2017, the mean NCD policy implementation score was 49·3% (SD 18·4%). Costa Rica and Iran had the joint-highest implementation scores (86·1% of all WHO-recommended policies). Scores were lowest in Haiti and South Sudan (5·5%). Between 2015 and 2017, aggregate implementation scores rose in 109 countries and regressed in 32 countries. Mean implementation rose for all of the 18 policies except for those targeting alcohol and physical activity. The most commonly implemented policies were clinical guidelines, graphic warnings on tobacco packaging, and NCD risk factor surveys. Our multiple linear regression model explained 61·1% of the variance in 2017 aggregate scores (p<0·0001), but we found evidence of a high degree of collinearity between the explanatory variables.InterpretationImplementation of WHO-recommended NCD policies is increasing over time. On average, countries implemented just under half of the NCD policies recommended by WHO in 2017. Nutrition-related policies saw gains, while those related to alcohol and physical activity were the most likely to have been dropped. Aggregate implementation scores tended to be highest in high-income countries that invest in health care and education.FundingNational Institute for Health Research, Imperial College London, University of Oxford.
Bortezomib Induces an Antioxidant and ER-Stress Response Gene Expression Signature in Mantle Cell Lymphoma: Implications for Response Prediction and Optimized Chemotherapy Regimens.
Authors: Edgar G. Rizzatti, Helena Mora-Jensen, Raymond Lai, Masanori Daibata, Therese White, Kieron Dunleavy, Wyndham Wilson, Adrian Wiestner
Journal: Blood (2006)
Parent-Measured and Parent-Estimated Child’s Heights and Weights
Authors: Xiangling Deng, Wenquan Niu
Journal: JAMA Pediatrics (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Specific Peptide Disruption of the Bcl-6 Repression Complex Reveals Its Transcriptional Mechanism of Action in Normal and Malignant B-Cells and Is a Novel Therapeutic Approach for Diffuse Large B-Cell Lymphoma.
Authors: Jose M. Polo, Tania Dell’Oso, Stella Maris Ranuncolo, Leandro Cerchietti, Gustavo F. Da Silva, Gilvert G. Prive, Jonathan D. Licht, Ari Melnick
Journal: Blood (2004)
The distribution of transferrin saturation in an asymptomatic Australian population: relevance to the early diagnosis of hemochromatosis Washington, from. December 1-5, 1995.
Authors: C.E. McLaren, G.J. McLachlan, S.J. Webb, E.C. Jazwinska, D.H.G. Crawford, V.R. Gordeuk, G.D. McLaren, LW Powell
Journal: Blood (1995)
Anti-Leukemic Effect of a Synthetic Compound, (±)Trans-Dihydronarciclasione (HYU-01) Via Cell Cycle Arrest and Apoptosis
Authors: Seoju Kim, Jinsun Yoon, Eun Shil Kim, Byoungbae PARK, Junghye Choi, Insoon Kim, Byoung Kook Kim, Young Lee
Journal: Blood (2008)
Effectiveness of Prompt Mental Health Care, the Norwegian Version of Improving Access to Psychological Therapies: A Randomized Controlled Trial
Authors: Marit Knapstad, Linn Vathne Lervik, Solbjørg Makalani Myrtveit Sæther, Leif Edvard Aarø, Otto Robert F. Smith
Journal: Psychotherapy and Psychosomatics (2019)

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; The innovative treatment model Improving Access to Psychological Therapies (IAPT) and its Norwegian adaptation, Prompt Mental Health Care (PMHC), have been evaluated by cohort studies only. Albeit yielding promising results, the extent to which these are attributable to the treatment thus remains unsettled. &lt;b&gt;&lt;i&gt;Objective:&lt;/i&gt;&lt;/b&gt; To investigate the effectiveness of the PMHC treatment compared to treatment as usual (TAU) at 6-month follow-up. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; A randomized controlled trial with parallel assignment was performed in two PMHC sites (Sandnes and Kristiansand) and enrolled clients between November 9, 2015 and August 31, 2017. Participants were 681 adults (aged ≥18 years) considered for admission to PMHC due to anxiety and/or mild to moderate depression (Patient Health Questionnaire [PHQ-9]/Generalized Anxiety Disorder scale [GAD-7] scores above cutoff). These were randomly assigned (70:30 ratio; &lt;i&gt;n&lt;/i&gt; = 463 to PMHC, &lt;i&gt;n&lt;/i&gt; = 218 to TAU) with simple randomization within each site with no further constraints. The main outcomes were recovery rates and changes in symptoms of depression (PHQ-9) and anxiety (GAD-7) between baseline and follow-up. Primary outcome data were available for 73/67% in PMHC/TAU. Sensitivity analyses based on observed patterns of missingness were also conducted. Secondary outcomes were work participation, functional status, health-related quality of life, and mental well-being. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; A reliable recovery rate of 58.5% was observed in the PMHC group and of 31.9% in the TAU group, equaling a between-group effect size of 0.61 (95% CI 0.37 to 0.85, &lt;i&gt;p&lt;/i&gt; &amp;#x3c; 0.001). The differences in degree of improvement between PMHC and TAU yielded an effect size of –0.88 (95% CI –1.23 to –0.43, &lt;i&gt;p&lt;/i&gt; &amp;#x3c; 0.001) for PHQ-9 and –0.60 (95% CI –0.90 to –0.30, &lt;i&gt;p&lt;/i&gt; &amp;#x3c; 0.001) for GAD-7 in favor of PMHC. All sensitivity analyses pointed in the same direction, with small variations in point estimates. Findings were slightly more robust for depressive than anxiety symptoms. PMHC was also more effective than TAU in improving all secondary outcomes, except for work participation (&lt;i&gt;z&lt;/i&gt; = 0.415, &lt;i&gt;p&lt;/i&gt; = 0.69). &lt;b&gt;&lt;i&gt;Conclusions:&lt;/i&gt;&lt;/b&gt; The PMHC treatment was substantially more effective than TAU in alleviating the burden of anxiety and depression. This adaptation of IAPT is considered a viable supplement to existing health services to increase access to effective treatment for adults who suffer from anxiety and mild to moderate depression. A potential effect on work participation needs further examination.
Political events and mood among young physicians: a prospective cohort study
Authors: Elena Frank, Brahmajee K Nallamothu, Zhuo Zhao, Srijan Sen
Journal: BMJ (2019)

Abstract Objective To study the effects of recent political events on mood among young physicians. Design Prospective cohort study. Setting United States medical centres. Participants 2345 medical interns provided longitudinal mood data as part of the Intern Health Study between 2016 and 2018. Main outcome measures Mean mood score during the week following influential political and non-political events as compared with mean mood during the preceding four week control period. Results We identified nine political events and eight non-political events for analysis. With the start of internship duties in July, the mean decline in mood for interns was −0.30 (95% confidence interval −0.33 to −0.27, t=−17.45, P&lt;0.001). The decline in mood was of similar magnitude following the 2016 presidential election (mean mood change −0.32, 95% confidence interval −0.45 to −0.19, t=−4.73, P&lt;0.001) and subsequent inauguration (mean mood change −0.25, 95% confidence interval −0.37 to −0.12, t=−3.93, P&lt;0.001). Further, compared with men, women reported greater mood declines after both the 2016 election (mean gender difference 0.31, 95% confidence interval 0.05 to 0.58, t=2.33, P=0.02) and the inauguration (mean gender difference 0.25, 95% confidence interval 0.01 to 0.49, t=2.05, P=0.04). Overall, there were statistically significant changes in mood following 66.7% (6/9) of political events assessed. In contrast, none of the non-political events included in the analysis were statistically significantly associated with a change in mood. Conclusions Macro level factors such as politics may be correlated with the mood of young doctors. This finding signals the need for further evaluation of the consequences of increasing entanglement between politics and medicine moving forward for young physicians and their patients.
Decreased beta2-Glycoprotein I Plasma Levels as a Risk Factor for Myocardial Infarction in Men.
Authors: Bas De Laat, Philip G. de Groot, Ronald H.W.M. Derksen, Rolf T. Urbanus, Koen Mertens, Frits Rosendaal, Carine J.M. Doggen
Journal: Blood (2008)
Medicine, Money and Manpower — The Challenge to Professional Education
Authors: Ward Darley, Anne R. Somers
Journal: New England Journal of Medicine (1967)

ALTHOUGH it is crucial that the numbers of health and medical personnel be increased, it is equally crucial that this personnel be used in the most efficient and effective manner possible. It is necessary that the system of education be geared to serve both these ends.The preceding papers have defined the pressures and opportunities that are compelling the present system of professional education to respond to these two problems. These papers also indicate that this educational response should be brought under the umbrella of philosophies and patterns of organization that will permit a team approach to patient care and . . .
Stroke reduction with atorvastatin in acute coronary syndromes : Results of the myocardial ischemia reduction with aggressive cholesterol lowering (MIRACL) trial
Authors: D Waters, GG Schwartz, Anders Olsson, MF Oliver, P Ganz, Ezekowitz, S Leslie, T Stern
Journal: Circulation (2001)

Stroke reduction with atorvastatin in acute coronary syndromes :  Results of the myocardial ischemia reduction with aggressive cholesterol lowering (MIRACL) trial
Abstract 16980: Defining the Arrhythmia Burden in Adults With Repaired Coarctation of the Aorta
Authors: Lauren T Lastinger, Omer Cavus, Lauren Hassen, Elisa Bradley
Journal: Circulation (2018)

Introduction: Ventricular and atrial arrhythmias have been shown to correlate with the risk of sudden cardiac death (SCD) in adult congenital heart disease (ACHD). Patients with repaired coarctation of the aorta (CoA) remain one of the highest risk ACHD populations for late SCD. However, the etiology of SCD is poorly understood in this population. Hypothesis: We hypothesize that adults with repaired CoA have an increased prevalence of atrial and ventricular arrhythmia. Methods: We identified 165 adults with repaired CoA (39±11years old, 45% women) and retrospectively analyzed all cardiac rhythm testing (2008-2018). The prevalence of atrial fibrillation (AF), atrial flutter (AFL), supraventricular tachycardia (SVT) and non-sustained ventricular tachycardia (NSVT) were analyzed and compared to prevalence in the general (non-repaired CoA) population. Results: Ventricular and atrial arrhythmia were found to be more common in adults with repaired CoA. The odds of NSVT occurring were 2.4 (95% CI: 1.5-3.8). Atrial arrhythmia risk varied by type with the odds of atrial arrhythmia in the CoA group ranging from 4.4 to 129 times the risk of the general population (See Figure). Conclusions: In this relatively young cohort of adults with repaired CoA, the incidence of ventricular and atrial arrhythmia was significantly higher than the general population. This data indicates that further study of arrhythmogenic substrate for SCD in repaired CoA is important.