tbuckley/cabot-search huggingface dataset:
Prise en charge endoscopique de 345 tumeurs neuro-endocrines du rectum
Authors: C Fine, M Pioche, V Hervieu, G Roquin, E Terrebonne, T Lecomte, R Coriat, C Docao, L de Mestier, E Coffin, G Cadiot, P Niccoli, V Lepilliez, V Hautefeuille, P Girot, FL Vélayoudom-Céphise, J Forestier, T Walter
Journal: Endoscopy (2019)

Les petites tumeurs neuroendocrines (TNE) du rectum sont de bons candidats à la résection endoscopique, à condition que celle-ci soit carcinologiquement complète (R0) et que le risque d'évolution métastatique soit faible. Cependant les résections endoscopiques doivent encore faire la preuve de leur efficacité. Nous avons donc mené une étude nationale multicentrique pour évaluer les résultats de la prise en charge endoscopique des TNE rectales initialement non métastatiques ≤2 cm.
The role of misclassification of exposure in the association between aspirin and nonsteroidal anti‐inflammatory drug use and keratinocyte cancers
Authors: S. Abtahi, O.A. Oshagbemi, A. Veelen, R.M.J.M. Geel
Journal: British Journal of Dermatology (2019)

Linked Article: Pandeya et al. Br J Dermatol 2019; DOI: 10.1111/bjd.17938
Abstract 16037: Genetic Absence of the Leukocyte Integrin Mac-1 Potentiates Adipose Tissue Inflammation by Enhancing Immune Cell Infiltration
Authors: Dennis Wolf, Eva Nora Bukosza, Felix Jehle, Florian Willecke, Ingo Hilgendorf, Peter Stachon, Christoph Bode, Karlheinz Peter, Andreas Zirlik
Journal: Circulation (2012)

Background: Infiltration with inflammatory and immune cells is a prerequisite of adipose tissue inflammation during the metabolic syndrome. β2-integrins, such as Mac-1, are classic adhesive recepto...
Association of Stroke Among Adults Aged 18 to 49 Years With Long-term Mortality
Authors: Merel Sanne Ekker, Jamie Inge Verhoeven, Ilonca Vaartjes, Wilhelmus Martinus Tim Jolink, Catharina Johanna Maria Klijn, Frank-Erik de Leeuw
Journal: JAMA (2019)

<h3>Importance</h3> Stroke remains the second leading cause of death worldwide. Approximately 10% to 15% of all strokes occur in young adults. Information on prognosis and mortality specifically in young adults is limited. <h3>Objective</h3> To determine short- and long-term mortality risk after stroke in young adults, according to age, sex, and stroke subtype; time trends in mortality; and causes of death. <h3>Design, Setting, and Participants</h3> Registry- and population-based study in the Netherlands of 15 527 patients aged 18 to 49 years with first stroke between 1998 and 2010, and follow-up until January 1, 2017. Patients and outcomes were identified through linkage of the national Hospital Discharge Registry, national Cause of Death Registry, and the Dutch Population Register. <h3>Exposures</h3> First stroke occurring at age 18 to 49 years, documented using<i>International Classification of Diseases, Ninth Revision</i>, and<i>International Statistical Classification of Diseases and Related Health Problems, Tenth Revision</i>, codes for ischemic stroke, intracerebral hemorrhage, and stroke not otherwise specified. <h3>Main Outcomes and Measures</h3> Primary outcome was all-cause cumulative mortality in 30-day survivors at end of follow-up, stratified by age, sex, and stroke subtype, and compared with all-cause cumulative mortality in the general population. <h3>Results</h3> The study population included 15 527 patients with stroke (median age, 44 years [interquartile range, 38-47 years]; 53.3% women). At end of follow-up, a total of 3540 cumulative deaths had occurred, including 1776 deaths within 30 days after stroke and 1764 deaths (23.2%) during a median duration of follow-up of 9.3 years (interquartile range, 5.9-13.1 years). The 15-year mortality in 30-day survivors was 17.0% (95% CI, 16.2%-17.9%). The standardized mortality rate compared with the general population was 5.1 (95% CI, 4.7-5.4) for ischemic stroke (observed mortality rate 12.0/1000 person-years [95% CI, 11.2-12.9/1000 person-years]; expected rate, 2.4/1000 person-years; excess rate, 9.6/1000 person-years) and the standardized mortality rate for intracerebral hemorrhage was 8.4 (95% CI, 7.4-9.3; observed rate, 18.7/1000 person-years [95% CI, 16.7-21.0/1000 person-years]; expected rate, 2.2/1000 person-years; excess rate, 16.4/1000 person-years). <h3>Conclusions and Relevance</h3> Among young adults aged 18 to 49 years in the Netherlands who were 30-day survivors of first stroke, mortality risk compared with the general population remained elevated up to 15 years later.
Response to: ‘Blood plasma versus serum: which is right for sampling circulating membrane microvesicles in human subjects?’ by Liu<i>et al</i>
Authors: Yasuhiro Kato, JeongHoon Park, Hyota Takamatsu, Atsushi Kumanogoh
Journal: Annals of the Rheumatic Diseases (2019)

The correspondence on our study is very much appreciated.1 We have shown that the microvesicles (MVs) in the serum from patients with systemic lupus erythematisus *(SLE) contain higher concentration of double strand DNA (dsDNA) and have higher interferon-stimulated gene (ISG)-inducing activity than healthy controls. In the letter from Liu et al , authors addressed several concerns regarding the use of serum-derived MVs in experiments since these may not represent the physiological MVs present in the circulation of patients with SLE.2 We agree that plasma is preferable for the preparation of MVs. However, reporter activity could not be evaluated using …
Prise en charge des perforations digestives endoscopiques avant et après les recommandations européennes ESGE (2015): élaboration d'une charte radio-médicochirurgicale basée sur l'évidence locale
Authors: G Bertrand, J Rivory, JC Saurin, M Robert, E Pelascini, O Monneuse, L Gruner, GC Poncet, PJ Valette, H Gimonet, F Rostain, C Ber, Y Bouffard, J Jacques, T Ponchon, M Pioche
Journal: Endoscopy (2019)

Les perforations sont un effet indésirable connu des procédures endoscopiques. Une proposition de prise en charge adaptée devrait être disponible dans chaque centre et partagée avec les radiologues et les chirurgiens comme le recommande l'ESGE. L'objectif de notre étude était d'analyser rétrospectivement les résultats des prises en charge des perforations dans notre centre avant et après 2016, afin de créer un algorithme de gestion basé sur des preuves locales.
L'incision muqueuse transversale au cours du POEM facilite l'accès à la sous muqueuse
Authors: C Jung, M Barret, B Brieau, B Bordacahar, S Leblanc, F Prat, S Chaussade
Journal: Endoscopy (2019)

La myotomie perorale endoscopique (POEM) est un traitement validé dans l'achalasie et d'autres troubles moteurs oesophagiens obstructifs. La technique initialement décrite par Inoue et al. accède à la sous muqueuse au moyen d'une incision longitudinale de la muqueuse oesophagienne. Au cours de la tunnelisation de la sous muqueuse, la muqueuse oesophagienne peut être mise en tension par l'endoscope, déchirée, et l'incision muqueuse involontairement étendue. Nous proposons d'évaluer la faisabilité et la sécurité d'une incision muqueuse transversale de l'oesophage.
Controlled decongestion by Reprieve therapy in acute heart failure: results of the TARGET‐1 and TARGET‐2 studies
Authors: Jan Biegus, Robert Zymlinski, Pawel Siwolowski, Jeffrey Testani, Joanna Szachniewicz, Agnieszka Tycińska, Waldemar Banasiak, Andrew Halpert, Howard Levin, Piotr Ponikowski
Journal: European Journal of Heart Failure (2019)
ENDOSCOPIC MUCOSAL RESECTION OF LARGE COLORECTAL LESIONS BY LOW-VOLUME ENDOSCOPISTS: A RETROSPECTIVE STUDY
Authors: CI Puscasu, R Oprea, A Mihai Voiosu, A Bengus, B Radu Mateescu, TA Voiosu
Journal: Endoscopy (2019)

In expert hands, endoscopic mucosal resection (EMR) is a safe and effective method for managing superficial neoplastic lesions of the lower GI tract. We aimed to evaluate the technical outcome and safety of colon EMR performed by endoscopists with limited experience in advanced resection techniques.
EVALUATION OF A NEW DEMILUNE SHAPED DEVICE FOR RAPID ENDOSCOPIC SUBMUCOSAL DISSECTION (ESD)
Authors: H Neumann, T Zimmermann, P Grimminger, KF Rahman, F Thieringer, PR Galle, K Mönkemüller, W Kneist
Journal: Endoscopy (2019)

ESD has been established as an effective treatment option for early gastrointestinal cancer. To date, various devices for ESD are available. Most recently, a novel, demilune shaped device was introduced potentially allowing for fast submucosal cutting due to its special design which allows rapid movements of the device above the muscle layer. I addition, the device allows for selective grasping of the vessels thereby enabling ad hoc haemostasis.
FEASIBILITY OF ENDOSCOPIC SUBMUCOSAL DISSECTION USING DETACHABLE ROBOTIC ASSITIVE DEVICE
Authors: SH Jang, HS Choi, SH Kim, HJ Jeon, SJ Choi, SH Kim, JM Lee, ES Kim, B Keum, YT Jeen, HJ Chun, HS Lee, CD Kim
Journal: Endoscopy (2019)

Endoscopic submucosal dissection (ESD) is a standard treatment treatment of early gastric cancer without lymph node dissection. However, ESD still takes long procedure time and ESD related complications still exist. One of those reason is that there is no proper counter-traction during procedure. Many ways have been tried to overcome these limitations. Recently, our research team developed Endoscopic Assistive Robot (EAR). In this study, we improved previous Endoscopic assistive robot and conducted an in vivo test to evaluate the efficacy and safety of our device.
Interconnected Toroidal Hydrogels for Islet Encapsulation
Authors: Alexander U. Ernst, Long‐Hai Wang, Minglin Ma
Journal: Advanced Healthcare Materials (2019)

Abstract Islet encapsulation and transplantation promises to improve upon current treatments for type 1 diabetes mellitus, though several limitations remain. Macroscale devices have been designed for in vivo transplantation and retrieval, but traditional geometries do not support clinically adequate mass transfer of nutrients to and insulin from the encapsulated tissue. Microcapsule technologies have improved mass transfer properties, but their clinical translation remains challenging as their complete retrieval is difficult, should the graft become a safety concern. Here, the design, characterization and testing of a novel encapsulation structure, comprised of elastomer‐reinforced interconnected toroidal hydrogels is reported. These donut‐shaped hydrogels feature a high surface area, higher than conventional spherical capsules of the same volume, bestowing suitable mass transport conditions, while allowing interconnection and reversible deformation for intraperitoneal implantation and retrieval. Diabetes correction up to 12 weeks and complete retrieval is achieved in a diabetic mouse model, providing a proof‐of‐concept for the potential application as a type 1 diabetes cell replacement therapy.
A HEAD TO HEAD ANALYSIS OF ENDOSCOPIC ULTRASOUND AND ENDO-BRONCHIAL ULTRASOUND GUIDED FINE NEEDLE ASPIRATION OF SUB-CARINAL LYMPHADENOPATHY
Authors: S Mehmood, N Ali, S Bilal, MA Yusuf, A Loya
Journal: Endoscopy (2019)

Very few studies have compared the diagnostic utility of these two tests in sub-carinal lymphadenopathy. The aim of this study was to compare effectiveness and safety of both modalities and assess their diagnostic accuracy.
Annals Graphic Medicine - Almost a Doctor
Authors: Mollie Kotzen
Journal: Annals of Internal Medicine (2019)

Web Exclusives21 May 2019Annals Graphic Medicine - Almost a DoctorFREEMollie Kotzen, MD, MPHMollie Kotzen, MD, MPHPennsylvania Hospital, Philadelphia, Pennsylvania (M.K.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/G19-0009 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Download figure Download PowerPoint Download figure Download PowerPoint Download figure Download PowerPoint Download figure Download PowerPoint Download figure Download PowerPoint Comments0 CommentsSign In to Submit A Comment Adam KortowskiSolo Internist12 June 2019 Typical Even when 30 years postgrad You have the same feeling of not having done your homework. Author, Article, and Disclosure InformationAffiliations: Pennsylvania Hospital, Philadelphia, Pennsylvania (M.K.)Disclosures: The author has disclosed no conflicts of interest. The form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=G18-0006.Author/Illustrator Information: Mollie Kotzen, MD, MPH, is an obstetrics and gynecology resident at Pennsylvania Hospital in Philadelphia (e-mail, mollie.[email protected]upenn.edu).This article was published at Annals.org on 14 May 2019. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 21 May 2019Volume 170, Issue 10Page: W116-W120KeywordsConflicts of interestDisclosureHealth careObstetrics and gynecologyResidency ePublished: 14 May 2019 Issue Published: 21 May 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
EFFICACY OF PURASTAT IN UPPER AND LOWER ACUTE GASTROINTESTINAL BLEEDING: A DUAL CASE SERIES EXPERIENCE
Authors: G de Nucci, R Reati, M Dinelli, D Redaelli, D Morganti, E Domenico Mandelli, G Manes
Journal: Endoscopy (2019)

Gastrointestinal (GI) bleeding is a common cause for hospitalization, resulting in significant mortality and morbidity. Innovative topical hemostatic modalities have been developed for endoscopic use. Our aim is to demostrate the efficacy, feasibility and safety of Purastat to control GI bleedings. Puramatrix is a synthetic, bioresorbable material used to produce Purastat, created to control venous/arteriolar bleedings, It's easy, quick and trasparent allowing to continue the procedure/to use other haemostatic therapies.
Exosomal Induction of Tumor Innervation
Authors: Paola D. Vermeer
Journal: Cancer Research (2019)

Abstract The naïve view of tumors as isolated islands of rogue cells has given way to a deeper understanding of cancer as being closer to a foreign organ. This “organ” contains immunologic, vascular, and neural connections to its host that provide not only mechanisms for disease progression but also opportunities for therapeutic intervention. The presence of nerves within tumor tissues has long been appreciated. However, a mechanistic understanding of how tumors recruit nerves has been slower to emerge. Tumor release of neurotrophic factors and axonal guidance molecules likely directs axons toward the tumor bed. Newly emerging data support a contribution of tumor-released exosomes in the induction of axonogenesis toward the tumor. Exosomes, small membrane-bound vesicles that carry a complex cargo (DNA, RNA, miRNA, lipids, and proteins), protect their cargo from the low pH of the tumor microenvironment. They also represent an efficient means of local and distal communication between the tumor and potentially innervating nerves. Likely, a combination of neurotrophins, guidance molecules, and exosomes work in concert to promote tumor innervation. As such, defining the critical components driving tumor innervation will identify new targets for intervention. Moreover, with a deepening understanding, tumor innervation may emerge as a new hallmark of cancer.
A Phase I Dose-Escalation Trial of BN-CV301, a Recombinant Poxviral Vaccine Targeting MUC1 and CEA with Costimulatory Molecules
Authors: Margaret E. Gatti-Mays, Julius Strauss, Renee N. Donahue, Claudia Palena, Jaydira Del Rivero, Jason M. Redman, Ravi A. Madan, Jennifer L. Marté, Lisa M. Cordes, Elizabeth Lamping, Alanvin Orpia, Andrea Burmeister, Eva Wagner, Cesar Pico Navarro, Christopher R. Heery, Jeffrey Schlom, James L. Gulley
Journal: Clinical Cancer Research (2019)

BN-CV301 is a poxviral-based vaccine comprised of recombinant (rec.) modified vaccinia Ankara (MVA-BN-CV301; prime) and rec. fowlpox (FPV-CV301; boost). Like its predecessor PANVAC, BN-CV301 contains transgenes encoding tumor-associated antigens MUC1 and CEA as well as costimulatory molecules (B7.1, ICAM-1, and LFA-3). PANVAC was reengineered to make it safer and more antigenic.This open-label, 3+3 design, dose-escalation trial evaluated three dose levels (DL) of MVA-BN-CV301: one, two, or four subcutaneous injections of 4 × 108 infectious units (Inf.U)/0.5 mL on weeks 0 and 4. All patients received FPV-CV301 subcutaneously at 1 × 109 Inf.U/0.5 mL every 2 weeks for 4 doses, then every 4 weeks. Clinical and immune responses were evaluated.There were no dose-limiting toxicities. Twelve patients enrolled on trial [dose level (DL) 1 = 3, DL2 = 3, DL3 = 6). Most side effects were seen with the prime doses and lessened with subsequent boosters. All treatment-related adverse events were temporary, self-limiting, grade 1/2, and included injection-site reactions and flu-like symptoms. Antigen-specific T cells to MUC1 and CEA, as well as to a cascade antigen, brachyury, were generated in most patients. Single-agent BN-CV301 produced a confirmed partial response (PR) in 1 patient and prolonged stable disease (SD) in multiple patients, most notably in KRAS-mutant gastrointestinal tumors. Furthermore, 2 patients with KRAS-mutant colorectal cancer had prolonged SD when treated with an anti-PD-L1 antibody following BN-CV301.The BN-CV301 vaccine can be safely administered to patients with advanced cancer. Further studies of the vaccine in combination with other agents are planned.See related commentary by Repáraz et al., p. 4871.
Efficacy of using imprint and exfoliative cytology followed by frozen section as intraoperative margin assessment in breast conservation surgery
Authors: T. Tamanuki, M. Namura, T. Aoyagi, S. Shimizu, T. Suwa, H. Matsuzaki
Journal: Annals of Oncology (2019)

Background: Intraoperative imprint and exfoliative cytology (IEC) or frozen section (FS) are margin assessment techniques to reduce reoperation risk. These techniques reduce the rate of positive margin on permanent section (PS) after breast conservation surgery (BCS), which lead to reduction of reoperation. The rate of positive margin using these techniques are reported accounts for 6–19% of BCS. However, previous studies reported only the single use of each method. The purpose of this study was to elucidate the efficacy of using IEC followed by FS as intraoperative margin assessment (IMA) in BCS regarding the positive margin rate of PS. Methods: Four hundred and fifty-one women who were admitted to our institution and underwent BCS between January 2013 and November 2018, and participated in this study. At first, IEC was performed as IMA. When the margin was likely to be positive by IEC result, FS was added. Additional excision was performed in patients with positive margin FS. We have analyzed the rate of positive margin on PS based on our margin assessment techniques. Results: Of 451 patients, 121 (26.8%) patients were IEC-positive and 330 (73.2%) patients were IEC-negative. Among these 121 patients who were added FS, 87 (71.9%) patients were FS-positive. Also, 10 (3.0%) of 330 patients with IEC-negative had positive margin with PS. Of 34 patients with FS-negative, no PS-positive patients were found. Though 87 patients with FS-positive received additional excision, only 3 patients resulted in PS-positive. Overall positive margin rate on final pathology according to PS was 2.9% (13 of 451 patients). Conclusions: Technique of IMA using IEC followed by FS improved positive margin rate of PS compared to that in the previous studies. Our techniques should contribute to reducing reoperation risk. Legal entity responsible for the study: The authors. Funding: Has not received any funding. Disclosure: All authors have declared no conflicts of interest.
A randomised phase II study investigating durvalumab in addition to an anthracycline taxane-based neoadjuvant therapy in early triple-negative breast cancer: clinical results and biomarker analysis of GeparNuevo study
Authors: S. Loibl, M. Untch, N. Burchardi, J. Huober, B.V. Sinn, J.-U. Blohmer, E.-M. Grischke, J. Furlanetto, H. Tesch, C. Hanusch, K. Engels, M. Rezai, C. Jackisch, W.D. Schmitt, G. von Minckwitz, J. Thomalla, S. Kümmel, B. Rautenberg, P.A. Fasching, K. Weber, K. Rhiem, C. Denkert, A. Schneeweiss
Journal: Annals of Oncology (2019)
Clinical factors associated with peanut allergy in a high‐risk infant cohort
Authors: Scott H. Sicherer, Robert A. Wood, Tamara T. Perry, Stacie M. Jones, Donald Y. M. Leung, Alice K. Henning, Peter Dawson, A. Wesley Burks, Robert Lindblad, Hugh A. Sampson
Journal: Allergy (2019)

Abstract Background Prognostication of peanut allergy (PNA) is relevant for early interventions. We aimed to determine baseline parameters associated with the development of PNA in 3‐ to 15‐month‐olds with likely egg and/or milk allergy, and/or moderate to severe atopic dermatitis (AD) and a positive egg/milk skin prick test (SPT), but no known PNA. Methods The primary endpoint was PNA [confirmed/convincing diagnosis or last classified as serologic PNA (&lt;2 years, ≥5 kUA/L, otherwise ≥14 kUA/L, peanut IgE)] among 511 participants (median follow‐up, 7.3 years). Associations were explored with univariate logistic regression; factors with P &lt; 0.15 were analyzed by stepwise multiple logistic regression, using data stratified by PNA status and randomly assigned to development and validation datasets. Results 205/511 (40.1%) had PNA. Univariate factors associated with PNA ( P &lt; 0.01) included increased AD severity, larger egg and peanut SPT, greater egg, milk, peanut, Ara h1‐h3 IgE, higher peanut IgG and IgG4, and increased pregnancy peanut consumption. P ‐values were between 0.01 and 0.05 for younger age, non‐white race, lack of breastfeeding, and increased lactation peanut consumption. Using a development dataset, the multivariate model identified younger age at enrollment, greater peanut and Ara h2 IgE, and lack of breastfeeding as prognosticators. The final model predicted 79% in the development and 75% in the validation dataset (AUC = 0.83 for both). Models using stricter or less strict PNA criteria both found Ara h2 as predictive. Conclusions Key factors associated with PNA in this high‐risk population included lack of breastfeeding, age, and greater Ara h2 and peanut‐specific IgE, which can be used to prognosticate outcomes.
ENDOSCOPIC TREATMENT OF INTRALUMINAL DUODENAL ("WINDSOCK") DIVERTICULUM WITH DIVERTICULOTOMY
Authors: AC Gatto Paulo, L Alves da Cruz Teixeira, A Andrade Franciscani Peixoto, F Alves Retes, P Coelho Fraga Moreira, PF Souto Bittencourt, LR Alberti, E Fraga Moreira
Journal: Endoscopy (2019)

Intraluminal duodenal diverticulum (IDD), also known as windsock's diverticulum is a rare congenital anomaly, which results from an incomplete recanalization of the foregut in the embryonic formation. Although most patients are asymptomatic, the most frequent symptoms are nausea, vomit, early satiety and epigastric discomfort. Complications are rare and include gastrointestinal bleeding, obstruction, pancreatitis and cholangitis. Endoscopic therapeutic can be used as an alternative treatment in symptomatic cases.
Plasmin-mediated fibrinolysis enables macrophage migration in a murine model of inflammation
Authors: Lakmali Munasinghage Silva, Andrew Gary Lum, Collin Tran, Molly W. Shaw, Zhen Gao, Matthew J. Flick, Niki M. Moutsopoulos, Thomas H. Bugge, Eric S. Mullins
Journal: Blood (2019)