tbuckley/cabot-search huggingface dataset:
EFFICACY AND SAFETY OF SODIUM PICOSULFATE-MAGNESIUM CITRATE IN BOWEL PREPARATION FOR ELDERLY IN KOREAN POPULATION: A PILOT STUDY
Authors: SH Kim, KW Lee, S Kim, SH Jang, HJ Jeon, SJ Choi, JM Lee, HS Choi, ES Kim, B Keum, YT Jeen, HS Lee, HJ Chun, CD Kim
Journal: Endoscopy (2020)

Aims Bowel preparation is one of the most important colonoscopy quality indicators. Sodium picosulfate-magnesium citrate (SP-MC) is getting more attention for its better tolerance and patient satisfaction compared to PEG-based solutions. However, its efficacy and safety in elderly patients has not been verified enough in Korean population. We compared the efficacy and safety of SP-MC compared to polyethyleneglycol (PEG) based bowel preparations in the elderly.
Should Immunoglobulin Therapy Be Used in Allogeneic Stem-Cell Transplantation?
Authors: Catherine Cordonnier, Sylvie Chevret, Marc Legrand, Homa Rafi, Nathalie Dhdin, Blandine Lehmann, Franois Bassompierre, Eliane Gluckman
Journal: Annals of Internal Medicine (2003)

This clinical trial showed that prophylactic immunoglobulin is not effective in patients undergoing allogeneic hematopoietic stem-cell transplantation.
A dose-finding Phase 2 study of single agent isatuximab (anti-CD38 mAb) in relapsed/refractory multiple myeloma
Authors: Joseph Mikhael, Joshua Richter, Ravi Vij, Craig Cole, Jeffrey Zonder, Jonathan L. Kaufman, William Bensinger, Meletios Dimopoulos, Nikoletta Lendvai, Parameswaran Hari, Enrique M. Ocio, Cristina Gasparetto, Shaji Kumar, Corina Oprea, Marielle Chiron, Claire Brillac, Eric Charpentier, Jesús San-Miguel, Thomas Martin
Journal: Leukemia (2020)

Abstract A Phase 2 dose-finding study evaluated isatuximab, an anti-CD38 monoclonal antibody, in relapsed/refractory multiple myeloma (RRMM; NCT01084252). Patients with ≥3 prior lines or refractory to both immunomodulatory drugs and proteasome inhibitors (dual refractory) were randomized to isatuximab 3 mg/kg every 2 weeks (Q2W), 10 mg/kg Q2W(2 cycles)/Q4W, or 10 mg/kg Q2W. A fourth arm evaluated 20 mg/kg QW(1 cycle)/Q2W. Patients ( N = 97) had a median (range) age of 62 years (38–85), 5 (2–14) prior therapy lines, and 85% were double refractory. The overall response rate (ORR) was 4.3, 20.0, 29.2, and 24.0% with isatuximab 3 mg/kg Q2W, 10 mg/kg Q2W/Q4W, 10 mg/kg Q2W, and 20 mg/kg QW/Q2W, respectively. At doses ≥10 mg/kg, median progression-free survival and overall survival were 4.6 and 18.7 months, respectively, and the ORR was 40.9% (9/22) in patients with high-risk cytogenetics. CD38 receptor density was similar in responders and non-responders. The most common non-hematologic adverse events (typically grade ≤2) were nausea (34.0%), fatigue (32.0%), and upper respiratory tract infections (28.9%). Infusion reactions (typically with first infusion and grade ≤2) occurred in 51.5% of patients. In conclusion, isatuximab is active and generally well tolerated in heavily pretreated RRMM, with greatest efficacy at doses ≥10 mg/kg.
The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer
Authors: Seth A. Wander, Ofir Cohen, Xueqian Gong, Gabriela N. Johnson, Jorge E. Buendia-Buendia, Maxwell R. Lloyd, Dewey Kim, Flora Luo, Pingping Mao, Karla Helvie, Kailey J. Kowalski, Utthara Nayar, Adrienne G. Waks, Stephen H. Parsons, Ricardo Martinez, Lacey M. Litchfield, Xiang S. Ye, Chunping Yu, Valerie M. Jansen, John R. Stille, Patricia S. Smith, Gerard J. Oakley, Quincy S. Chu, Gerald Batist, Melissa E. Hughes, Jill D. Kremer, Levi A. Garraway, Eric P. Winer, Sara M. Tolaney, Nancy U. Lin, Sean G. Buchanan, Nikhil Wagle
Journal: Cancer Discovery (2020)

Mechanisms driving resistance to cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) in hormone receptor-positive (HR+) breast cancer have not been clearly defined. Whole-exome sequencing of 59 tumors with CDK4/6i exposure revealed multiple candidate resistance mechanisms including RB1 loss, activating alterations in AKT1, RAS, AURKA, CCNE2, ERBB2, and FGFR2, and loss of estrogen receptor expression. In vitro experiments confirmed that these alterations conferred CDK4/6i resistance. Cancer cells cultured to resistance with CDK4/6i also acquired RB1, KRAS, AURKA, or CCNE2 alterations, which conferred sensitivity to AURKA, ERK, or CHEK1 inhibition. Three of these activating alterations-in AKT1, RAS, and AURKA-have not, to our knowledge, been previously demonstrated as mechanisms of resistance to CDK4/6i in breast cancer preclinically or in patient samples. Together, these eight mechanisms were present in 66% of resistant tumors profiled and may define therapeutic opportunities in patients. SIGNIFICANCE: We identified eight distinct mechanisms of resistance to CDK4/6i present in 66% of resistant tumors profiled. Most of these have a therapeutic strategy to overcome or prevent resistance in these tumors. Taken together, these findings have critical implications related to the potential utility of precision-based approaches to overcome resistance in many patients with HR+ metastatic breast cancer.This article is highlighted in the In This Issue feature, p. 1079.
Sedentary Time and Its Association With Risk for Disease Incidence, Mortality, and Hospitalization in Adults
Authors: Aviroop Biswas, Paul I. Oh, Guy E. Faulkner, Ravi R. Bajaj, Michael A. Silver, Marc S. Mitchell, David A. Alter
Journal: Annals of Internal Medicine (2015)

Physical activity has many health-enhancing benefits, but it may not be enough to reduce the risk for disease and illness. This systematic review and meta-analysis evaluated the association between...
Reply to the Letter to the Editor ‘Germline-somatic fluidity in guiding patient care. Reply to the Letter to the Editor “Choice of control tissue impacts designation of germline variants in a cohort of papillary thyroid carcinoma patients” by J. C. Rubinstein et al.’ by E. Hahn &amp; G. S. Charames
Authors: E.R. Christison-Lagay, J.C. Rubinstein
Journal: Annals of Oncology (2020)
TREATMENT OF HAEMORRHAGIC RADIATION PROCTITIS (HRP) BY ARGON PLASMA ELECTROCOAGULATION (APC): RESULTS AND COMPLICATIONS
Authors: K Loubaris, H Seddik, Ayoub Aomari, Samir Mrabti, Tarik Addajou, Ahlam Benhamdane, Hanae Boutallaka, Ilham El Koti, Sara Sentissi, Ahmed Benkirane
Journal: Endoscopy (2020)

Methods This is a retrospective and descriptive study between January 2009 and December 2018, including 46 patients with HRP. The technique used was a monopolar electrocoagulation with argon plasma.
IBD PATIENTS EQUALLY TOLERATE BOWEL PREPARATION BUT NEED HIGHER DOSES OF SEDATION DURING COLONOSCOPY: RESULTS FROM A PROSPECTIVE, CASE-CONTROL, SINGLE-CENTRE STUDY
Authors: C Bezzio, P Andreozzi, M Schettino, I Arena, C Della Corte, M Devani, G Manes, B Omazzi, S Saibeni
Journal: Endoscopy (2020)

Aims IBD patients are intended to undergo several times colonoscopy. To prospectively evaluate tolerability of bowel preparation and colonoscopy in UC and CD patients compared to subjects participating in a colorectal cancer population screening program.
Saline-Resistant Metabolic Alkalosis or "Chloride-Wasting Nephropathy"
Authors: Serafino Garella, Joseph A. Chazan, Jordan J. Cohen
Journal: Annals of Internal Medicine (2020)

Abstract Saline resistant metabolic alkalosis, which is characterized by the persistent urinary excretion of chloride in the presence of metabolic alkalosis, is known to occur in patients with hy...
Increasing accessibility in COVID-19 clinical trials
Authors: Vijay Shankar Balakrishnan
Journal: The Lancet Microbe (2020)

Just a week after WHO declared coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) a pandemic, on March 18, 2020, the agency launched a global clinical trial, named SOLIDARITY. Open to any country to participate, as of April 21, 2020, over 100 countries have signed up to take part in this single, large, randomised trial to find a treatment effective against COVD-19.
Phase 2 randomized, double-blind study of IL-17 targeting with secukinumab in atopic dermatitis
Authors: Benjamin Ungar, Ana B. Pavel, Randall Li, Grace Kimmel, John Nia, Peter Hashim, Hee Jin Kim, Margot Chima, Anjali S. Vekaria, Yeriel Estrada, Hui Xu, Xiangyu Peng, Giselle K. Singer, Danielle Baum, Yasaman Mansouri, Mark Taliercio, Emma Guttman-Yassky
Journal: Journal of Allergy and Clinical Immunology (2020)
68Ga-PSMA PET/CT and 18F-FDG PET/CT in Renal Cell Carcinoma
Authors: Ew-Jun Chen, Teik Hin Tan, Ming Tsuey Chew, Ping Ching Chye
Journal: Clinical Nuclear Medicine (2020)

Abstract Recent case reports and series have demonstrated the usefulness of 68 Ga/ 18 F-PSMA PET/CT in restaging recurrent renal cancer after nephrectomy. We presented a case of a patient with renal mass who had undergone both 18 F-FDG and 68 Ga-PSMA PET/CT for diagnosis and staging. Concordant tracer uptake in the primary tumor and metastatic lesions was demonstrated by both radiotracers. Final histopathological reports revealed clear cell renal cell carcinoma. Furthermore, unusual left metacarpal bone metastasis was also detected.
Acute Myocardial Infarction Temporally Related to Cocaine Use
Authors: Henry W. B. Smith, Henry A. Liberman, Steven L. Brody, Louis L. Battey, Bryan C. Donohue, Douglas C. Morris
Journal: Annals of Internal Medicine (2020)

Abstract Ischemic chest pain syndromes and myocardial infarction occurred within minutes to hours of cocaine use in nine persons ages 23 to 39 years. Five developed symptoms after taking cocaine in...
ENDOSCOPIC PAPILLECTOMY WITH CLOSURE OF THE DEFECT USING NEW RUSSIAN CLIP DEVICE
Authors: I Nedoluzhko, E Khon, K Shishin, N Kurushkina, L Shumkina
Journal: Endoscopy (2020)

The aim is to show the method of decreasing the risks of complication after endoscopic papillectomy. 68-year-old female was treated. Duodenoscopy and ultrasonography showed protruding tumor of papilla, size 3.0 × 1.5 cm. without invasion of the duodenal muscularis propria and no ductal infiltration.
Effectiveness of Leech Therapy in Osteoarthritis of the Knee
Authors: Andreas Michalsen, Stefanie Klotz, Rainer Ldtke, Susanne Moebus, Gnther Spahn, Gustav J. Dobos
Journal: Annals of Internal Medicine (2003)

Patients with osteoarthritis of the knee have reduced symptoms for at least 1 week after application of leeches. The pharmacologic properties of leech saliva that are responsible for this effect ar...
EFFICACY OF ENDOSCOPIC TOPICAL MITOMYCIN C APPLICATION IN CAUSTIC ESOPHAGEAL STRICTURES IN THE PEDIATRIC POPULATION: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
Authors: M Flor, IB Ribeiro, DTH de Moura, M Coronel, WM Bernardo, P Sakai, EGH de Moura
Journal: Endoscopy (2020)

Aims Caustic ingestion and consequential esophageal strictures constitute a significant health problem in childhood. Multiple sessions of endoscopic dilatation are usually required to manage caustic esophageal strictures. Recently, the application of topical mitomycin C as an adjuvant treatment with endoscopic dilatation therapy has shown promising results in improving symptoms and decreasing the number of dilation sessions. We aimed of this study is to evaluate the efficacy of endoscopic topical mitomycin C application in the treatment of caustic esophageal strictures in the pediatric population.
A PORCINE MODEL OF CROHN´S DISEASE ANASTOMOTIC STRICTURE FOR TRAINING IN ADVANCED ENDOSCOPIC TREATMENT METHODS
Authors: M Kolar, M Lukas, O Ryska, S Juhas, J Juhasova, J Kalvach, J Pazin, J Hadac, T Kocisova, O Foltan, H Kristianova, J Ptacnik, I Vitkova, M Bortlik, M Lukas
Journal: Endoscopy (2020)

Aims Currently, options in post-surgical recurrence of stricturing Crohn´s disease (CD) are limited to another surgery or balloon dilation with unsatisfactory long-term effects. However, development of new invasive endoscopic techniques is hindered by safety issues with testing these methods on patients. Aim was to create a large animal model of anastomotic stricture with CD properties enabling development of new endoscopic techniques and serving as a training subject for endoscopists to familiarize themselves with these methods.
PRE-ENDOSCOPIC INTRAVENOUS PROTON PUMP INHIBITORS HAVE NO IMPACT ON CLINICAL OUTCOMES IN ACUTE UPPER GASTROINTESTINAL BLEEDING: A PROSPECTIVE MULTICENTER ITALIAN COHORT STUDY
Authors: Riccardo Marmo, Marco Soncini, Cristina Bucci
Journal: Endoscopy (2020)

Aims Incidence of hospital admission for acute upper gastrointestinal bleeding (AUGIB) has decreased by 20% during the past 10 years, due to the changing epidemiology. The use of pre-endoscopic intravenous proton pump inhibitors (PPIs), currently recommended, is debated. Aim to verify if the use of pre-endoscopic PPIs improves the death and outcomes rate in these patients
Ethical and Sensible Dissemination of Information During the COVID-19 Pandemic
Authors: Farid Rahimi, Amin Talebi Bezmin Abadi
Journal: The American Journal of Bioethics (2020)

Following the report by the Wuhan Municipal Health Commission about a pneumonia case of unknown cause observed in a patient on 12 December 2019, initial news foreboding a clinical crisis surfaced (...
Urinary Frequency as a Possibly Overlooked Symptom in COVID-19 Patients: Does SARS-CoV-2 Cause Viral Cystitis?
Authors: Jan-Niclas Mumm, Andreas Osterman, Michael Ruzicka, Clemens Stihl, Theresa Vilsmaier, Dieter Munker, Elham Khatamzas, Clemens Giessen-Jung, Christian Stief, Michael Staehler, Severin Rodler
Journal: European Urology (2020)
EDUCATIONAL INTERVENTION FOR IMPROVING THE APPROPRIATENESS OF TRANSTHORACIC ECHOCARDIOGRAMS ORDERED BY PEDIATRIC CARDIOLOGISTS
Authors: Ritu Sachdeva, Michael S. Kelleman, Joseph Allen, Oscar Benavidez, Robert Campbell, Pamela Douglas, Benjamin Eidem, Lara Gold, Leo Lopez, Courtney McCracken, Kenan Stern, Rory Weiner, Elizabeth Welch, Wyman Lai
Journal: Journal of the American College of Cardiology (2016)
FACTORS AFFECTING THE QUALITY OF BOWEL PREPARATION FOR COLONOSCOPY IN THE ELDERLY: A RETROSPECTIVE ANALYSIS OF A PROSPECTIVE COHORT
Authors: M Maida, E Sinagra, G Morreale, S Sferrazza, G Scalisi, D Schillaci, G Vettori, G Conoscenti, CD Bartolo, D Catarella, S Garufi, M Manganaro, CM Virgilio, S Camilleri
Journal: Endoscopy (2020)

Aims This study aimed to assess the difference in bowel cleansing in the elderly compared to younger patients and to evaluate independent factors of cleansing success.
Duration of Antibiotic Therapy for Early Lyme Disease
Authors: Gary P. Wormser, Roshan Ramanathan, John Nowakowski, Donna McKenna, Diane Holmgren, Paul Visintainer, Rhea Dornbush, Brij Singh, Robert B. Nadelman
Journal: Annals of Internal Medicine (2003)

A 10-day course of doxycycline was sufficient for patients with erythema migrans. Extending doxycycline treatment to 20 days or adding one ceftriaxone dose at the beginning of a 10-day course of do...
Low dose CDDP+ACNU chemotherapy against gallbladder cancer via attenuation of MGMT gene expression by CDDP
Authors: Ken Sato, Atsushi Hagiwara, Yoshihiko Kitajima, Yasuo Koga, Kohji Miyazaki, Atsushi Miyoshi
Journal: Cancer Research (2004)

589  (Background) Biochemical modulation has been widely accepted as new strategy for cancer chemotherapy. We have reported that gallbladder (GB) cancer cell lines which lacked DNA-repair enzyme 06-methylguanine methyltransferase (MGMT) and possessed mismatch repair gene hMLH1 expression showed higher sensitivity to alkylating agents such as MNU and ACNU. On the other hand, CDDP has been reported to reduce MGMT expression and enzyme activity. Based on these findings, we designed novel modulation chemotherapy mediated via reducing MGMT expression by CDDP against MGMT+/hMLH1+ GB cancer which demonstrates resistance to alkylating agents. Furthermore, we analyzed the mechanism about this. (Material and Methods) (1) RT-PCR was performed to assess whether MGMT expression of GB cancer cell line (KMGC) was repressed by low dose CDDP at concentration 2.5, 5.0, 7.5 and 10 uM. (2) In KMGC cells, drug effects were compared between alkylating agent (ACNU) alone and CDDP(5uM) +ACNU using MTT assay. (3) We constructed several reporter plasmids connected to luciferase gene, in which MGMT promoter region was variously deleted (p -575/+224, S1: p –575/+141, S2: p –148/+141, S3: p –72/+141, S4: p +1/+141). These reporter plasmids were transiently transfected together with b-galactosidase plasmid into KMG-C cells. After 24hr exposure under 0∼5uM CDDP, we assessed relative lucifearse activity in the deletion reporter series. (Result) (1) RT-PCR: Under exposure to CDDP at various concentrations, MGMT expression in KMG-C cells was repressed in dose and time-dependent manner. (2) MTT assay: In KMGC cells, drug sensitivity to ACNU was increased >2-fold by pretreatment of 5uM CDDP, compared with no pretreatment. (3) Reporter promoter assay: Luciferase activity from MGMT promoter series including p, S1, S2 and S3 was inhibited by CDDP treatment in dose dependent manner. However, The repression by CDDP was not observed in the S4 deletion mutant, which lacked minimal promoter (72bp) region. (Conclusion) (1) We confirmed that low dose CDDP enhanced ACNU sensitivity in MGMT+/hMLH1+ KMGC cells, where CDDP repressed an alkyllating agent sensitive marker MGMT. (2) Reporter promoter assay strongly indicated that 72bp upstream region in MGMT promoter may be a crucial element for transcriptional suppression by CDDP. (3) These results may provide a new strategy in alkylating agent-based chemotherapy via biochemical modulation effect by pretreatment of low dose CDDP.
HD-WLE COLONOSCOPY AND CHROMOENDOSCOPY IN THE DETECTION OF DYSPLASIA IN LONG-STANDING ULCERATIVE COLITIS
Authors: S Skridlevskiy, O Arkhipova, O Maynovskaya, V Veselov
Journal: Endoscopy (2020)

Aims Improving approaches to the endoscopic diagnosis of ulcerative colitis (UC)-associated dysplasia includes improvement in the detection of dysplasia and labour intensity reduction of the diagnosis process. In this regard, the study aimed to determine the effectiveness of HD-WLE colonoscopy and chromoendoscopy in the detection of dysplasia in long-standing UC.
EVEN IN CASE OF A ‘SIMPLE’ PNET…ONE NEVER KNOWS WHAT TO EXPECT
Authors: P Cortegoso Valdivia, L Venezia, S Rizza, F Rizzi, M Gesualdo, M Pennazio, CGD Angelis
Journal: Endoscopy (2020)

Aims Pancreatic neuroendocrine tumors (pNETs) are known for their unpredictable behaviour. Even in case of apparent disease stability, progression of the disease must always be suspected.
Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade
Authors: Rui Yang, Samah Elsaadi, Kristine Misund, Pegah Abdollahi, Esten Nymoen Vandsemb, Siv Helen Moen, Anna Kusnierczyk, Geir Slupphaug, Therese Standal, Anders Waage, Tobias S Slørdahl, Torstein Baade Rø, Even Rustad, Anders Sundan, Carl Hay, Zachary Cooper, Alwin G Schuller, Richard Woessner, Alexandra Borodovsky, Eline Menu, Magne Børset, Anne Marit Sponaas
Journal: Journal for ImmunoTherapy of Cancer (2020)

PD1/PDL1-directed therapies have been unsuccessful for multiple myeloma (MM), an incurable cancer of plasma cells in the bone marrow (BM). Therefore, other immune checkpoints such as extracellular adenosine and its immunosuppressive receptor should be considered. CD39 and CD73 convert extracellular ATP to adenosine, which inhibits T-cell effector functions via the adenosine receptor A2A (A2AR). We set out to investigate whether blocking the adenosine pathway could be a therapy for MM.Expression of CD39 and CD73 on BM cells from patients and T-cell proliferation were determined by flow cytometry and adenosine production by Liquid chromatograpy-mass spectrometry (HPCL/MS). ENTPD1 (CD39) mRNA expression was determined on myeloma cells from patients enrolled in the publicly available CoMMpass study. Transplantable 5T33MM myeloma cells were used to determine the effect of inhibiting CD39, CD73 and A2AR in mice in vivo.Elevated level of adenosine was found in BM plasma of MM patients. Myeloma cells from patients expressed CD39, and high gene expression indicated reduced survival. CD73 was found on leukocytes and stromal cells in the BM. A CD39 inhibitor, POM-1, and an anti-CD73 antibody inhibited adenosine production and reduced T-cell suppression in vitro in coculture of myeloma and stromal cells. Blocking the adenosine pathway in vivo with a combination of Sodium polyoxotungstate (POM-1), anti-CD73, and the A2AR antagonist AZD4635 activated immune cells, increased interferon gamma production, and reduced the tumor load in a murine model of MM.Our data suggest that the adenosine pathway can be successfully targeted in MM and blocking this pathway could be an alternative to PD1/PDL1 inhibition for MM and other hematological cancers. Inhibitors of the adenosine pathway are available. Some are in clinical trials and they could thus reach MM patients fairly rapidly.
Liver Biochemistries in Hospitalized Patients With COVID‐19
Authors: Patricia P. Bloom, Eric A. Meyerowitz, Zoe Reinus, Michael Daidone, Jenna Gustafson, Arthur Y. Kim, Esperance Schaefer, Raymond T. Chung
Journal: Hepatology (2020)

Coronavirus disease 2019 (COVID-19) leads to elevated liver biochemistries in approximately half of patients on presentation. To date, data are limited regarding the trend of liver biochemistries over the course of illness. We aimed to evaluate the trend, etiology, and outcomes associated with liver biochemistries in COVID-19.A total of 60 patients with COVID-19 were admitted between March 21 and March 28, 2020. The mean age was 57 years, 65% were male, and 28% were Hispanic. At the study conclusion, 6 patients were deceased, 28 were discharged, and 26 remained admitted. Patients who remained admitted were followed for a median of 12 days. Of 60 patients, 41 (69%) had at least one abnormal liver biochemistry on admission. Median aspartate aminotransferase (AST) was higher than alanine aminotransferase (ALT) at admission (46 vs. 30 U/L) and during the hospital course. Aminotransferases rose above normal in 54 (93%) patients, whereas alkaline phosphatase and total bilirubin elevations were rare. Ten (17%) patients developed aminotransferases more than 5 times the upper limit of normal. AST highly correlated with ALT throughout the illness course (r = 0.97; P < 0.0001), whereas correlations with markers of muscle injury and inflammation were weak. Statin use was common before (40%) and during admission (80%) at our center, with no difference in peak liver biochemistries between users and nonusers. No demographic or comorbid illness was associated with liver injury. Admission AST (69 vs. 49; P < 0.05), peak AST (364 vs. 77; P = 0.003), and peak ALT (220 vs. 52; P = 0.002) were higher in intubated patients.AST-dominant aminotransferase elevation is common in COVID-19, mirrors disease severity, and appears to reflect true hepatic injury.
RISK FACTORS FOR FAILURE AND COMPLICATIONS OF ENDOSCOPIC PAPILLARY LARGE BALLOON DILATION (EPLBD) IN THE CLEARANCE OF DIFFICULT BILE DUCT STONES
Authors: M Alburquerque, ALV García, NZ Velasco, MF Francesc, JM Calafat, RB Clau, M Pechkova, IM Sala, JR Espinet, FGH Lladó
Journal: Endoscopy (2020)

Aims To determine risk factors for failure and complications of EPLBD in the clearance of difficult bile duct stones.
Factitious Fever and Self-Induced Infection
Authors: Robert P. Aduan, Anthony S. Fauci, David C. Dale, Joseph H. Herzberg, Sheldon M. Wolff
Journal: Annals of Internal Medicine (2020)

Abstract We review in detail the syndromes of factitious fever and self-induced infection, with discussion of 32 cases studied at the National Institutes of Health and the extensive English languag...
COLORECTAL CANCER INCIDENCE AND MORTALITY IN SUBJECTS WITH POSITIVE FAECAL IMMUNOCHEMICAL BLOOD TEST WHO DO NOT ATTEND SCREENING COLONOSCOPY
Authors: M Zorzi, C Hassan, J Battagello, G Capodaglio, G Martin, G Antonelli, A Greco, C Stocco, S Zamberlan, M Rugge
Journal: Endoscopy (2020)

Aims In the colorectal cancer screening programmes of the Veneto region, compliance with colonoscopy among subjects with a positive faecal immunochemical test (FIT) is firmly less than 90%. We compared the incidence of colorectal cancer (CCR) and cause-specific mortality in subjects with a positive who complied or did not comply with colonoscopy.