tbuckley/cabot-search huggingface dataset:
Abstract 114: A Role for Brain-derived Neurotrophic Factor in Duchenne Cardiomyopathy
Authors: Cristi L Galindo, Cassandra P Awgulewitsch, Jonathan H Soslow, Lin Zhong, Erica J Carrier, Anand P Singh, Prachi Umbakar, Qinkun Zhang, Frank Raucci, Larry W Markham, Hind Lal, Antonis K Hatzopoulos
Journal: Circulation Research (2018)

Brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin receptor kinase B (TrkB) harbor cardioprotective qualities that may attenuate CM. In a small cohort of DMD patients we found that BDNF blood levels positively correlated with preserved ejection fraction (EF) and less fibrosis, and carriers of the common BDNF single nucleotide polymorphism rs6265 (Val66-Met) tended to exhibit earlier age of onset of fibrosis with subsequent progression to LV dysfunction, compared to non-carriers. We thus hypothesized that BDNF/TrkB signaling delays CM progression in DMD. To test this hypothesis, we administered the TrkB agonist 7,8-dihydroxyflavone (DHF) to mdx 4cv ; mTR KO mice in their drinking water for 26 weeks, beginning at 8 weeks of age. Based on echocardiography, DHF treatment preserved cardiac output compared to vehicle-treated controls. Conversely, mdx 4cv ; mTR KO mice injected intraperitoneally with the TrkB inhibitor (K252a) displayed bradycardia and PR interval prolongation, as measured by EKG, as well as acute (10-20 min) reduction in percent EF and fractional shortening, as measured by echocardiography. K252a also significantly reduced sarcomere shortening in isolated murine cardiomyocytes. BDNF might also contribute to cardiac repair. Using humanized BDNF polymorphic mice, which have the Val66-Met mutation, we found that post-myocardial infarction cardiac dysfunction was significantly exacerbated in Met/Met mice compared to Val/Val littermate controls. Finally, we evaluated the role of BDNF/TrkB in human cardiomyocytes differentiated from induced pluripotent cells obtained from DMD patients (DMD iPSC-CMs) and found that they highly express BDNF protein in lysates and supernatants. DMD iPSC-CMs also expressed a truncated version of TrkB that lacks the tyrosine kinase domain essential for canonical BDNF/TrkB signaling. Nonetheless, DMD iPSC-CMs responded to treatment with recombinant BDNF, including increased phosphorylation of GSK-3α, mTOR, AMPK, and MSK1/2. Considered together, our results indicate that BDNF plays a protective role in the dystrophic heart and might represent a novel therapeutic candidate for DMD cardiomyopathy.
Abstract #LB-135: Grapefruit juice significantly increases bioavailability of weekly rapamycin (sirolimus) - evidence of safety and activity in a phase 1 study
Authors: Ezra Cohen, Christine Hartford, Michael Maitland, Kammi Fox-Kay, Pamela Vogel, Kehua Wu, Mark Ratain
Journal: Cancer Research (2009)

Background: mTOR inhibitors have activity in several cancers. The class prototype, rapamycin (R), has low oral bioavailability. Grapefruit juice (GJ) contains furanocoumarins that increase bioavailability of many drugs that undergo P450 metabolism. We hypothesized that GJ would increase AUC of R administered weekly, allowing tolerable, convenient, and cost-effective delivery of an mTOR inhibitor. Methods: R was administered orally once weekly using an adaptive escalation design based on AUC. R alone was administered in week 1 and with GJ (240 ml QD) from week 2 onwards. Pharmacokinetic parameters were compared with and without GJ. Patients with non-measurable disease were permitted to enroll. Results: 28 subjects [15 males and 13 females (ages 27 - 77)] with advanced solid tumors were enrolled. R was escalated in cohorts of 15 (n=5), 20 (n=5), 25 (n=5), and 35 (n=13) mg. The table shows mean AUC and Cmax of R vs. R+GJ. Dose limiting toxicity was observed in 2 subjects at 25 mg (grade 3 hyperglycemia) and 35 mg (grade 3 mucositis). The most commonly observed toxicities were hyperglycemia (75%), diarrhea (68%), lymphopenia (57%), fatigue (54%), and hyperlipidemia (50%). Of the 25 evaluable subjects, best observed responses included 1 partial response and 7 stable disease. The partial response was observed in a patient diagnosed with metastatic epithelioid hemangioendothelioma who had been previously treated with sorafenib and has received R+GJ for 40 weeks. Conclusions: The addition of GJ to R significantly increases the AUC and Cmax of R approximately 4-fold and 2-fold, respectively. The combination of R+GJ is well tolerated without unexpected toxicities. R exposure at 35 mg po is at least comparable to that achieved with temsirolimus 25 mg iv. Further studies are indicated in tumors of vascular origin as well as other malignancies (e.g., renal cancer).$$table_{35B2EBBE-C746-4D1F-99E9-A8777F1CB2B7}$$ *2-sided t-test for AUC R vs. R+GJ  Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr LB-135.
THE CARDIOVASCULAR EFFECTS OF CHIMERIC ANTIGEN RECEPTOR T-CELLS
Authors: Raza M. Alvi, Syed Mahmood, Malek Z.O. Hassan, Magid Awadalla, Lili Zhang, Connor P. Mulligan, Adam Rokicki, Noopur Raje, Jeremy Abramson, Matthew J. Frigault, Tomas G. Neilan
Journal: Journal of the American College of Cardiology (2019)
ALTERED SERCA2A EXPRESSION IN MITRAL VALVE LEAFLETS IN CHRONIC ISCHEMIC MITRAL REGURGITATION
Authors: Tarek Sami Absi, Cristi L. Galindo, Richard Gumina, Kelsey Tomasek, Alexandra Foshage, Christopher Groark, James Atkinson, Keki Balsara, Clayton Allen Kaiser, Ashish Shah, Yan Ru Su
Journal: Journal of the American College of Cardiology (2019)
Acute Disseminated Encephalomyelitis After Chikungunya Infection
Authors: Anderson Alexsander Rodrigues Teixeira, Lucas Fernandes Ferreira, Roberto da Justa Pires Neto
Journal: JAMA Neurology (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
MICROVASCULAR CORONARY DYSFUNCTION IS A HARBINGER FOR ATHEROSCLEROSIS: A CASE OF ACCELERATED ATHEROSCLEROSIS IN A PATIENT WITH UNDIAGNOSED IDIOPATHIC AORTITIS AND MICROVASCULAR DYSFUNCTION
Authors: Nchang Taka, Megan Toole, Myrna Alexander Nickens
Journal: Journal of the American College of Cardiology (2019)
IATROGENIC AORTIC PLAQUE DEHISCENCE CAUSED BY ROTATIONAL ATHERECTOMY IN A PATIENT WITH SEVERE AORTIC STENOSIS SUCCESSFULLY TREATED WITH TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Syed Yaseen Naqvi, Erik Howell, Jeffrey Bruckel, Thomas Stuver
Journal: Journal of the American College of Cardiology (2019)
PROGNOSTIC IMPACT OF LEFT VENTRICULAR MASS INDEX REGRESSION AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT IN PATIENTS WITH LEFT VENTRICULAR HYPERTROPHY
Authors: Jin Kyung Oh, Dae-Hee Kim, Jong-Min Song, Seung-Ah Lee, Do-Yoon Kang, Sahmin Lee, Duk-Woo Park, Duk-Hyun Kang, Jae-Kwan Song, Seung-Jung Park
Journal: Journal of the American College of Cardiology (2019)
CARDIOMYOCYTE SPECIFIC DELETION OF PLASMA MEMBRANE CALCIUM ATPASE1 (PMCA1CKO) MAY EXACERBATE CARDIAC REMODELLING AFTER MYOCARDIAL INFARCTION IN MURINE MODEL
Authors: Hatim Alsusa, Tahir Nazir, Sukhpal Prehar, Florence Baudoin, Min Zi, Elizabeth Cartwright
Journal: Journal of the American College of Cardiology (2019)
Genomic Features of Exceptional Response in Vemurafenib ± Cobimetinib–treated Patients with <i>BRAF</i>V600-mutated Metastatic Melanoma
Authors: Yibing Yan, Matthew J. Wongchenko, Caroline Robert, James Larkin, Paolo A. Ascierto, Brigitte Dréno, Michele Maio, Claus Garbe, Paul B. Chapman, Jeffrey A. Sosman, Zhen Shi, Hartmut Koeppen, Jessie J. Hsu, Ilsung Chang, Ivor Caro, Isabelle Rooney, Grant A. McArthur, Antoni Ribas
Journal: Clinical Cancer Research (2019)

Abstract Purpose: Previous investigations identified transcriptional signatures associated with innate resistance to anti–programmed cell death protein 1 therapy in melanoma. This analysis aimed to increase understanding of the role of baseline genetic features in the variability of response to BRAF and MEK inhibitor therapy for BRAFV600-mutated metastatic melanoma. Patients and Methods: This exploratory analysis compared genomic features, using whole-exome and RNA sequencing, of baseline tumors from patients who had complete response versus rapid progression (disease progression at first postbaseline assessment) on treatment with cobimetinib combined with vemurafenib or vemurafenib alone. Associations of gene expression with progression-free survival or overall survival were assessed by Cox proportional hazards modeling. Results: Whole-exome sequencing showed that MITF and TP53 alterations were more frequent in tumors from patients with rapid progression, while NF1 alterations were more frequent in tumors from patients with complete response. However, the low frequency of alterations in any one gene precluded their characterization as drivers of response/resistance. Analysis of RNA profiles showed that expression of immune response–related genes was enriched in tumors from patients with complete response, while expression of keratinization-related genes was enriched in tumors from patients who experienced rapid progression. Conclusions: These findings suggest that enriched immune infiltration might be a shared feature favoring response to both targeted and immune therapies, while features of innate resistance to targeted and immune therapies were distinct.
TARGET WEIGHT: MEASURING THE IMPACT OF COMMUNICATING VOLUME STATUS GOALS TO IMPROVE HEART FAILURE MANAGEMENT ACROSS HEALTHCARE SETTINGS AND AT HOME
Authors: Sarah Hallen, Heidi R. Wierman, Richard Marino, Douglas Sawyer, Samuel Coffin, Esther S. Shao, Ann M. Cannon, Melissa Caminiti, Richard Veilleux
Journal: Journal of the American College of Cardiology (2019)
EFFECT OF SACUBITRIL/VALSARTAN INITIATION ON 30-DAY READMISSIONS AFTER A HOSPITALIZATION FOR ACUTE DECOMPENSATED HEART FAILURE: A SECONDARY ANALYSIS OF THE PIONEER-HF TRIAL
Authors: Adam DeVore, David Morrow, Eugene Braunwald, Carol I. Duffy, Andrew P. Ambrosy, Kevin McCague, Ricardo Rocha, Eric Velazquez
Journal: Journal of the American College of Cardiology (2019)
Inflammation: a common contributor to cancer, aging, and cardiovascular diseases—expanding the concept of cardio-oncology
Authors: Peter Libby, Sebastian Kobold
Journal: Cardiovascular Research (2019)

Inflammation participates in the pathogenesis of both cancer and cardiovascular disease. This review examines the mechanistic commonalities between these two scourges of humanity through the lens of inflammation biology. Inflammatory pathways contribute to the initiation, the progression, and the complication of both malignant tumours and atherosclerotic plaques. Modulation of inflammatory pathways have proven transformative in the treatment of cancers and have crossed the threshold of clinical reality as treatments to reduce the risk of cardiovascular events. The finding that clonal haematopoiesis drives both leukaemia and cardiovascular events provides yet another link between these two seemingly disparate diseases. The nascent specialty of cardio-oncology has initially focused on the cardiovascular complications of cancer therapies. The recognition of a more profound pathophysiologic connection between cancer and cardiovascular diseases should expand the concept of cardio-oncology. Embracing the mechanistic connection and transcending traditional barriers between disciplines offers immense opportunities for speeding innovative research that can address the growing burden of both cancer and cardiovascular disease.
CARDIAC AND SYSTEMIC INFLAMMATORY BURDEN PREDICTS CARDIAC RECOVERY IN VENTRICULAR ASSIST DEVICE PATIENTS: A PROSPECTIVE STUDY
Authors: Nikolaos Diakos, Iosif Taleb, Omar Wever-Pinzon, Hadi Javan, Anna Catino, Elizabeth Dranow, Abdallah Kfoury, Rami Alharethi, Josef Stehlik, William Caine, Antigoni Koliopoulou, James Fang, Craig Selzman, Stavros Drakos
Journal: Journal of the American College of Cardiology (2019)
PROGNOSTIC SIGNIFICANCE OF NONOBSTRUCTIVE LEFT MAIN CORONARY ARTERY DISEASE IN DIABETES VERSUS NON-DIABETES: LONG-TERM OUTCOMES FROM THE CONFIRM REGISTRY
Authors: Juhwan Lee, Kashif Shaikh, Rine Nakanishi, Stephan Achenbach, Mouaz Al-Mallah, Jeroen J. Bax, Daniel Berman, Filippo Cademartiri, Tracy Callister, Hyuk-Jae Chang, Benjamin Chow, Ricardo Cury, Gudrun Feuchtner, Martin Hadamitzky, Joerg Hausleiter, Philipp Kaufmann, Jonathon Leipsic, Yong-Jin Kim, Hugo Marques, Gianluca Pontone, Gilbert Raff, Ronen Rubinshtein, Todd Villines, James Min, Matthew Budoff
Journal: Journal of the American College of Cardiology (2019)
ANNEXIN A1 A NOVEL BIOMARKER FOR CONGESTION IN ACUTE HEART FAILURE?
Authors: Seethalakshmi Iyer, Aruna Rikhi, Fadi Adel, Siu-Hin Wan, Hrishikesh Chakraborty, Wai Hong Tang, G. Michael Felker, Michael Givertz, Horng Chen
Journal: Journal of the American College of Cardiology (2019)
Novel and Significant Impact of Germline Variants Predisposed to Pathogenic Somatic Mutations and Loss of Heterozygosity (LOH) in Myelodysplastic Syndromes (MDS) and Clonal Hematopoiesis of Indeterminate Potential (CHIP)
Authors: Hideki Makishima, Tetsuichi Yoshizato, Yasuhito Nannya, Yasuhide Momozawa, Yoshiko Atsuta, Yusuke Shiozawa, Yuka Iijima-Yamashita, Kenichi Yoshida, Yuichi Shiraishi, Hiromichi Suzuki, June Takeda, Yasunobu Nagata, Yusuke Sato, Nobuyuki Kakiuchi, Makoto Onizuka, Keisuke Kataoka, Kenichi Chiba, Hiroko Tanaka, Hiroo Ueno, Masahiro Marshall Nakagawa, Hidehiro Itonaga, Yoshinobu Kanda, Yasushi Miyazaki, Keizo Horibe, Masashi Sanada, Yoichiro Kamatani, Michiaki Kubo, Satoru Miyano, Seishi Ogawa
Journal: Blood (2018)
Abstract 336: Human Bone Contains Primitive Cells With Angiogenic and Immunomodulatory Properties
Authors: Hajime Kubo, Eric Feldsot, Giana Schena, Alexander Hobby, Yijun Yang, Jaslyn Johnson, Polina Gross, Thomas Sharp, Sadia Mohsin, Remus Berretta, Eric T Choi, Joanne Donnelly, Hydel Christopher, Steven R Houser
Journal: Circulation Research (2018)

Previously, we have shown that treatments of cortical bone derived stem cells (CBSCs) reduce ventricular remodeling and improve cardiac functions in both mouse and pig myocardial infarction (MI) models. The goals of the present study were to isolate and characterize human CBSCs (hCBSCs). Using bone fragments obtained at the time surgeries, we isolated three morphologically distinctive hCBSC phenotypes; 1) sphere forming (SF); 2) epithelial like monolayer (ELM); and 3) larger and spindle shaped (LSS) phenotype. The hCBSC phenotypes grew without senescence in culture. Mean doubling time (hour) for SF, ELM, and LSS at the passage number 20 (P20) were 19.54, 21.21, and 20.3 respectively and at the P40 were 18.01, 17.13, and 20.56 respectively. All of the phenotypes were found to have surface expression of CD44; however, other markers detected (CD105, CD90, CD73, CD106, CD271, and CD133) on mouse CBSCs (mCBSCs) were not detected along with the markers not detected on the surface of mCBSCs (CD45, CD11b, CD31, CD34, CD117, and CD325). Erythrocytes (CD235a) and immune cell markers (CD2, CD3, CD14, CD16, CD19, and CD56) were also not detected. The hCBSCs were found without histocompatibility antigen Ia (MHC-Ia: HLA-A, HLA-B, and HLA-C) and MHC-II (HLA-DR); instead, they expressed soluble forms of MHC-Ib (HLA-G5, HLA-G6, and HLA-G7), potent inhibitor of natural killer cells and other immune cells. These features are commonly found in immune privileged cells. Further, the hCBSCs produced the immunomodulatory and anti-inflammatory factors (IL-4, IL-1RA, TGF-b and IL-10). Additionally, the hCBSCs secreted angiogenic factors that organize endothelial cells into tube like structures. From these results, the hCBSCs we isolated have totally different surface marker characteristics compared to any other known cells including mCBSCs. In addition to their angiogenic effects, the hCBSCs have immunomodulatory properties that could make them suitable for cell therapy targeting inflammatory diseases such post myocardial infarction remodeling.
Design of a NGS Platform for the Integrated Analysis of Genetic Mutations, Copy Number Alteration and Somatic Hypermutation of IGHV in CLL
Authors: Miguel Alcoceba, Maria Garcia-Alvarez, Anna Puiggros, Luis Espinosa-Hevia, Andrea Gómez-Llonín, Almudena Navarro, Jose Maria Bastida, Norma C. Gutierrez, Jose A. Garcia-Marco, Blanca Espinet, Ramón García-Sanz, Marcos González
Journal: Blood (2018)
Clarifications Needed on Study of Association Between Physician Burnout and Patient Safety
Authors: Lotte N. Dyrbye, Tait D. Shanafelt, Colin P. West
Journal: JAMA Internal Medicine (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Abstract 279: Evaluation of Prehospital Therapeutic Hypothermia for Comatose Resuscitated Patients in Japanese Doctor-Car System
Authors: Hirotaka Sawano, Noritoshi Ito, Yuma Kurozumi, Daisuke Tonomura, Tomoaki Natsukawa, Yasuyuki Hayashi, Tatsuro Kai
Journal: Circulation (2010)

Background: Mild therapeutic hypothermia (MTH) has been integrated to improve the neurological outcome in out-of-hospital cardiac arrest. Several studies reported the effectiveness of prehospital M...
COMPARATIVE EFFECTIVENESS AND SAFETY OF NON-VITAMIN K ANTAGONIST ORAL ANTICOAGULANTS AMONG FRAIL NONVALVULAR ATRIAL FIBRILLATION PATIENTS
Authors: Gregory Y.H. Lip, Allison Keshishian, Amiee Kang, Amol Dhamane, Xuemei Luo, Xiaoyan Li, Neeraja Balachander, Lisa Rosenblatt, Jack Mardekian, Xianying Pan, Manuela Di Fusco, Alessandra Bassalobre Garcia, Huseyin Yuce, Steven Deitelzweig
Journal: Journal of the American College of Cardiology (2019)
LOW AND ELEVATED B-TYPE NATRIURETIC PEPTIDE LEVELS ARE ASSOCIATED WITH INCREASED MORTALITY IN PATIENTS WITH PRESERVED EJECTION FRACTION UNDERGOING TRANSCATHETER AORTIC VALVE REPLACEMENT: FROM THE PARTNER 2 TRIAL AND REGISTRIES
Authors: Shmuel Chen, Bjorn Redfors, Brian O'Neill, Marie-Annick Clavel, Philippe Pibarot, Sammy Elmariah, Tamim Nazif, Aaron Crowley, Ori Ben-Yehuda, Matthew Finn, Maria Alu, Torsten Vahl, Rebecca Hahn, Susheel Kodali, Martin Leon, Brian Lindman
Journal: Journal of the American College of Cardiology (2019)
Differential food protein‐induced inflammatory responses in swine lines selected for reactivity to soy antigens
Authors: Seika Hashimoto‐Hill, Myunghoo Kim, Leon Friesen, Kolapo M. Ajuwon, Eliot Herman, Allan Schinckel, Chang H. Kim
Journal: Allergy (2019)

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Abstract 215: Induced Pluripotent Stem Cell-Derived Cardiomyocyte Proliferation is Enhanced by Co-culture With Female Mesenchymal Stem Cells
Authors: Amarylis B Wanschel, Alessandro G Salerno, Konstantinos E Hatzistergos, Ivonne H Schulman, Wayne Balkan, Joshua Hare
Journal: Circulation Research (2018)

Background: Myocardial ischemia remains a leading cause of morbidity and mortality worldwide. Bone marrow-derived adult mesenchymal stem cells (MSCs) improve cardiac structure and function post-MI likely mediated in large part by paracrine factors. There is emerging evidence that female MSCs have greater therapeutic efficacy than male MSCs. Objective: We hypothesized that female MSCs promote cardiomyocyte differentiation, proliferation and contractility of induced pluripotent stem cells (iPSCs) better than male MSCs. Methods &amp; Results: Human (h) iPSCs were co-cultured with male or female murine MSCs during or after differentiation into beating cardiomyocytes. Female MSCs were significantly more potent at stimulating ISL-1 and NKX2-5 expression in hiPSC-derived cardiac precursors and cardiomyocytes. Exosomes from female MSCs had lower levels of miR-17, a miR that directly represses Isl1 . hiPSCs co-cultured with female MSCs, exhibited a 2-fold greater increase in proliferation compared to male MSCs. In addition, ß 2 -adrenergic receptor expression was up regulated 3.5-fold in hiPSCs incubated with female MSCs compared to 2.5-fold for male MSCs. Conclusion: Our findings illustrate that there are significant differences between female and male MSCs in their ability to affect cardiomyogenesis of hiPSCs and suggest that this effect is mediated, at least in part, by reduced levels of miR-17. The observation that female MSCs have greater potential to improve cardiomyocyte proliferation and contractility has important implications for stem cell therapy.
Abstract 19823: Exposure to High Level PM2.5 Causes Increased Central Blood Pressure
Authors: Shixuan Wang, Dandan Xu, Litong Qi, Yi Zhang, Jia Jia, Fangfang Fan, Long Zhang, Tiantian Li, Yan Zhang
Journal: Circulation (2017)

Introduction: Central blood pressure (BP) has been increasingly recognized as having a closer relationship with cardiovascular risks than peripheral BP. Epidemiological studies have shown that expo...