tbuckley/cabot-search huggingface dataset:
Cost analysis and barriers to implementing and sustaining an international surgical resident rotation: a retrospective review
Authors: Ogechukwu Onuh, Rebecca Fisher, Stephen Trinidad, Celia Divino, Michael Marin, Pedro Trejo, Prerna Khetan, Linda Zhang
Journal: The Lancet Global Health (2020)

BackgroundThe overwhelming need and interest in global surgery has led to increasing numbers of international surgery resident rotations. Despite the validity of global surgical education, financial and logistical barriers remain when implementing these international rotations. The Mount Sinai Department of Surgery, New York, USA, established an international resident rotation in 2005. Here, we describe some of the costs and barriers to establishing and maintaining a global surgery rotation with the aim of providing a guideline for academic institutions interested in building an international rotation.MethodsThis study is a retrospective review of the international rotation with the Hospital Jose Maria Cabral y Báez (Cabral) in Santiago, Dominican Republic. The exchange programme is an opportunity for two resident doctors from Dominican Republic to join Mount Sinai third year residents in a 1-month surgical rotation. We reviewed data collected from budgets, financial investments, resident and programme director experiences, and formal agreements between the two institutions.FindingsWith the Mount Sinai funding, there have been three residents from the Dominican Republic who have completed an exchange rotation at the Mount Sinai Hospital. An optimum international site requires a balanced alliance between the US academic institution and the international site. The Cabral and Mount Sinai collaborative partnership allows residents from both institutions to benefit from the exchange of experiences and surgical practices. Site selection is contingent on: hospital infrastructure (eg, operative variety and volume, faculty oversight); suitable living accommodations that allow personal safety, access to food, running water, electricity, and an internet connection; and overcoming language barriers. Successful implementation requires a time commitment from staff at both institutions. The monthly operational cost of this programme is US$3530, with 37% for visiting resident accommodation, 30% for transport, 20% for visiting resident expenses, and 13% for health and communication expenses. The time required by the US programme director includes an annual trip to the international rotation site and approximately 100 h per year, which includes monthly orientations and debriefings, and research. Finally, this programme requires adherence to Accreditation Council for Graduate Medical Education and Residency Review Committee guidelines.InterpretationGlobal academic surgery combines surgery with education, clinical service, research, and advocacy in resource-limited settings. Mitigation of logistical barriers and addressing financial costs allows for successful global academic surgery programmes.FundingNone
Prevalence of Continuous Pulse Oximetry Monitoring in Hospitalized Children With Bronchiolitis Not Requiring Supplemental Oxygen
Authors: Christopher P. Bonafide, Rui Xiao, Patrick W. Brady, Christopher P. Landrigan, Canita Brent, Courtney Benjamin Wolk, Amanda P. Bettencourt, Lisa McLeod, Frances Barg, Rinad S. Beidas, Amanda Schondelmeyer
Journal: JAMA (2020)

US national guidelines discourage the use of continuous pulse oximetry monitoring in hospitalized children with bronchiolitis who do not require supplemental oxygen. Measure continuous pulse oximetry use in children with bronchiolitis. A multicenter cross-sectional study was performed in pediatric wards in 56 US and Canadian hospitals in the Pediatric Research in Inpatient Settings Network from December 1, 2018, through March 31, 2019. Participants included a convenience sample of patients aged 8 weeks through 23 months with bronchiolitis who were not receiving active supplemental oxygen administration. Patients with extreme prematurity, cyanotic congenital heart disease, pulmonary hypertension, home respiratory support, neuromuscular disease, immunodeficiency, or cancer were excluded. Hospitalization with bronchiolitis without active supplemental oxygen administration. The primary outcome, receipt of continuous pulse oximetry, was measured using direct observation. Continuous pulse oximetry use percentages were risk standardized using the following variables: nighttime (11 pm to 7 am), age combined with preterm birth, time after weaning from supplemental oxygen or flow, apnea or cyanosis during the present illness, neurologic impairment, and presence of an enteral feeding tube. The sample included 3612 patient observations in 33 freestanding children's hospitals, 14 children's hospitals within hospitals, and 9 community hospitals. In the sample, 59% were male, 56% were white, and 15% were black; 48% were aged 8 weeks through 5 months, 28% were aged 6 through 11 months, 16% were aged 12 through 17 months, and 9% were aged 18 through 23 months. The overall continuous pulse oximetry monitoring use percentage in these patients, none of whom were receiving any supplemental oxygen or nasal cannula flow, was 46% (95% CI, 40%-53%). Hospital-level unadjusted continuous pulse oximetry use ranged from 2% to 92%. After risk standardization, use ranged from 6% to 82%. Intraclass correlation coefficient suggested that 27% (95% CI, 19%-36%) of observed variation was attributable to unmeasured hospital-level factors. In a convenience sample of children hospitalized with bronchiolitis who were not receiving active supplemental oxygen administration, monitoring with continuous pulse oximetry was frequent and varied widely among hospitals. Because of the apparent absence of a guideline- or evidence-based indication for continuous monitoring in this population, this practice may represent overuse.
Low anterior resection syndrome (LARS) in ovarian cancer patients - A multi-centre comparative cohort study
Authors: Felix Harpain, Marlene Kranawetter, Tobias Zott, Ioannis I. Lazaridis, Marc-Olivier Guenin, Marijana Ninkovic, Irmgard E. Kronberger, Ingrid Tapiolas, Eloy Espin Basany, Bernhard Dauser, Friedrich Herbst, Cherry Koh, Anton Stift, Bela Teleky, Alexander Reinthaller, Christoph Grimm, Stefan Riss
Journal: International Journal of Surgery (2020)
Cytotoxic Therapy–Induced Effects on Both Hematopoietic and Marrow Stromal Cells Promotes Therapy-Related Myeloid Neoplasms
Authors: Angela Stoddart, Jianghong Wang, Anthony A. Fernald, Elizabeth M. Davis, Camille R. Johnson, Chunmei Hu, Jason X. Cheng, Megan E. McNerney, Michelle M. Le Beau
Journal: Blood Cancer Discovery (2020)

Abstract Therapy-related myeloid neoplasms (t-MN) following treatment with alkylating agents are characterized by a del(5q), complex karyotypes, alterations of TP53, and a dismal prognosis. To decipher the molecular pathway(s) leading to the pathogenesis of del(5q) t-MN and the effect(s) of cytotoxic therapy on the marrow microenvironment, we developed a mouse model with loss of two key del(5q) genes, EGR1 and APC, in hematopoietic cells. We used the well-characterized drug, N-ethyl-N-nitrosurea (ENU), to demonstrate that alkylating agent exposure of stromal cells in the microenvironment increases the incidence of myeloid disease. In addition, loss of Trp53 with Egr1 and Apc was required to drive the development of a transplantable leukemia, and accompanied by the acquisition of somatic mutations in DNA damage response genes. ENU treatment of mesenchymal stromal cells induced cellular senescence and led to the acquisition of a senescence-associated secretory phenotype, which may be a critical microenvironmental alteration in the pathogenesis of myeloid neoplasms. Significance: This study challenges the historic view that prior cytotoxic therapy targets only hematopoietic cells and shows that chemotherapy-induced alterations to the microenvironment contribute to myeloid neoplasms in a model of del(5q) t-MN. The DNA damage response in hematopoietic cells and senescence of stromal cells are identified as potential therapeutic targets. See related commentary by Shannon and Link, p. 10. This article is highlighted in the In This Issue feature, p. 5
SELDI-TOF Identifies Specific Protein Patterns in Small Lymphocytic Lymphoma, Marginal Zone Lymphoma and Mantle Cell Lymphoma.
Authors: Delphine Rolland, Ali Bouamrami, Benoit Ballester, Samuel Grangeaud, Marie Arlotto, Aurelie Paret, Francoise Berger, Pascale Felman, Evelyne Callet-Bauchu, Bertrand Coiffier, Remi Houlgatte, Francois Berger, Catherine Thieblemont
Journal: Blood (2005)
Decreased Vagal Activity and Deviation in Sympathetic Activity Precedes Development of Diabetes
Authors: Da Young Lee, Mi Yeon Lee, Jung Hwan Cho, Hyemi Kwon, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Won-Young Lee, Sung-Woo Park, Seungho Ryu, Se Eun Park
Journal: Diabetes Care (2020)

OBJECTIVE The objective of this study was to examine whether altered heart rate variability (HRV) could predict the risk of diabetes in Asians. RESEARCH DESIGN AND METHODS A cohort study was conducted in 54,075 adults without diabetes who underwent 3-min HRV measurement during health checkups between 2011 and 2014 at Kangbuk Samsung Hospital. We analyzed the time domain (SD of the normal-to-normal interval [SDNN] and root mean square differences of successive normal-to-normal intervals [RMSSD]) and the frequency domain (total power, normalized low-frequency power [LF], and normalized high-frequency power [HF] and LF/HF ratio). We compared the risk of diabetes until 2017 according to tertiles of heart rate and HRV variables, with tertile 1 serving as the reference group. RESULTS During 243,758.2 person-years, 1,369 subjects were diagnosed with diabetes. Both time and frequency domain variables were lower in the group with diabetes, with the exception of those with normalized LF and LF/HF ratio. In Cox analysis, as SDNN, RMSSD, and normalized HF tertiles increased, the risk of diabetes decreased (hazard ratios [95% CIs] of tertile 3: 0.81 [0.70–0.95], 0.76 [0.65–0.90], and 0.78 [0.67–0.91], respectively), whereas the risk of diabetes increased in the case of heart rate, normalized LF, and LF/HF ratio (hazard ratios [95% CIs] of tertile 3: 1.41 [1.21–1.65], 1.32 [1.13–1.53], and 1.31 [1.13–1.53), respectively) after adjusting for age, sex, BMI, smoking, drinking, systolic blood pressure, lipid level, CRP, and HOMA of insulin resistance. CONCLUSIONS Abnormal HRV, especially decreased vagal activity and deviation in sympathovagal imbalance to sympathetic activity, might precede incident diabetes.
Analysis of Early Intervention Services on Adult Judicial Outcomes
Authors: Jessica M. Pollard, Maria Ferrara, I-Hsin Lin, Suat Kucukgoncu, Tobias Wasser, Fangyong Li, Vinod H. Srihari
Journal: JAMA Psychiatry (2020)

This secondary analysis of a randomized clinical trial assesses the association of specialty team-based services for first-episode psychosis with criminal justice outcomes compared with usual treatment.
Riociguat in patients with early diffuse cutaneous systemic sclerosis (RISE-SSc): randomised, double-blind, placebo-controlled multicentre trial
Authors: Dinesh Khanna, Yannick Allanore, Christopher P Denton, Masataka Kuwana, Marco Matucci-Cerinic, Janet E Pope, Tatsuya Atsumi, Radim Bečvář, László Czirják, Eric Hachulla, Tomonori Ishii, Osamu Ishikawa, Sindhu R Johnson, Ellen De Langhe, Chiara Stagnaro, Valeria Riccieri, Elena Schiopu, Richard M Silver, Vanessa Smith, Virginia Steen, Wendy Stevens, Gabriella Szücs, Marie-Elise Truchetet, Melanie Wosnitza, Kaisa Laapas, Janethe de Oliveira Pena, Zhen Yao, Frank Kramer, Oliver Distler
Journal: Annals of the Rheumatic Diseases (2020)

Riociguat is approved for pulmonary arterial hypertension and has antiproliferative, anti-inflammatory and antifibrotic effects in animal models of tissue fibrosis. We evaluated the efficacy and safety of riociguat in patients with early diffuse cutaneous systemic sclerosis (dcSSc) at high risk of skin fibrosis progression.In this randomised, double-blind, placebo-controlled, phase IIb trial, adults with dcSSc of <18 months' duration and a modified Rodnan skin score (mRSS) 10-22 units received riociguat 0.5 mg to 2.5 mg orally three times daily (n=60) or placebo (n=61). The primary endpoint was change in mRSS from baseline to week 52.At week 52, change from baseline in mRSS units was -2.09±5.66 (n=57) with riociguat and -0.77±8.24 (n=52) with placebo (difference of least squares means -2.34 (95% CI -4.99 to 0.30; p=0.08)). In patients with interstitial lung disease, forced vital capacity declined by 2.7% with riociguat and 7.6% with placebo. At week 14, average Raynaud's condition score had improved ≥50% in 19 (41.3%)/46 patients with riociguat and 13 (26.0%)/50 patients with placebo. Safety assessments showed no new signals with riociguat and no treatment-related deaths.Riociguat did not significantly benefit mRSS versus placebo at the predefined p<0.05. Secondary and exploratory analyses showed potential efficacy signals that should be tested in further trials. Riociguat was well tolerated.
Rituximab for granulomatosis with polyangiitis in the pandemic of covid-19: lessons from a case with severe pneumonia
Authors: Philippe Guilpain, Clément Le Bihan, Vincent Foulongne, Patrice Taourel, Nathalie Pansu, Alexandre Thibault Jacques MARIA, Boris Jung, Romaric Larcher, Kada Klouche, Vincent Le Moing
Journal: Annals of the Rheumatic Diseases (2020)

niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
Trends in Utilization of Prescribed Controlled Substances in US Commercially Insured Adults, 2004-2019
Authors: Katsiaryna Bykov, Mengdong He, Joshua J. Gagne
Journal: JAMA Internal Medicine (2020)

This study examines the most commonly dispensed categories and individual substances of all prescribed controlled substances, including stimulants, benzodiazepines, and depressants, among US commercially insured adults.
Targeting ANXA1 abrogates Treg-mediated immune suppression in triple-negative breast cancer
Authors: Fang Bai, Peng Zhang, Yipeng Fu, Hongliang Chen, Mingdi Zhang, Qianru Huang, Dan Li, Bin Li, Kejin Wu
Journal: Journal for ImmunoTherapy of Cancer (2020)

Background Regulatory T (Treg) cells play a negative role in anti-tumor immunity against triple-negative breast cancer, so it is of great significance to find the potential therapeutic target of Treg cells. Methods First, Annexin A1 (ANXA1) expression and survival of patients with breast cancer were analyzed using TCGA data. Then plasma ANXA1 levels in patients with malignant and benign breast tumors were detected by ELISA. Next, the effect of ANXA1 on Treg cells was studied through suppressive assays, and how ANXA1 regulates the function of Treg cells was detected by RNA sequencing. Finally, the in vivo experiment in balb/c mice was conducted to test whether the ANXA1 blocker Boc1 could shrink tumors and affect the function of Treg cells. Results Our data suggest that ANXA1 expression is associated with lower survival and a higher risk of breast malignancy. Suppressive assays show that ANXA1 can enhance the inhibition function of Treg cells. RNA-Sequencing results indicate that Boc1 could reduce the expression of granzyme A mRNA in Treg cells. Animal experiments have been done to show that Boc1 can reduce tumor size and down regulate Treg cell function. Conclusions ANXA1 can enhance the function of Treg cells and reduce the survival rate of patients with breast cancer. Targeting ANXA1 can reduce Treg cell function and shrink breast tumors.
Effect of intravenous IgG therapy on natural killer cell function related to Fc gamma receptor gene expression
Authors: Maria Papaserafeim, Peter Jandus, Ruxandra Iancu Ferfoglia, Jan P. Nieke, Cédric Vonarburg, Rolf Spirig, Gisella L. Puga Yung, Jörg D. Seebach
Journal: Journal of Allergy and Clinical Immunology (2020)
Adding oseltamivir to usual primary care reduced recovery time in influenza-like illness
Authors: Henry S. Sacks
Journal: Annals of Internal Medicine (2020)

Source Citation Butler CC, van der Velden AW, Bongard E, et al. Oseltamivir plus usual care versus usual care for influenza-like illness in primary care: an open-label, pragmatic, randomised controlled trial. Lancet. 2020;395:42-52. 31839279
Safety and immunogenicity of a modified vaccinia virus Ankara vector vaccine candidate for Middle East respiratory syndrome: an open-label, phase 1 trial
Authors: Till Koch, Christine Dahlke, Anahita Fathi, Alexandra Kupke, Verena Krähling, Nisreen M A Okba, Sandro Halwe, Cornelius Rohde, Markus Eickmann, Asisa Volz, Thomas Hesterkamp, Alen Jambrecina, Saskia Borregaard, My L Ly, Madeleine E Zinser, Etienne Bartels, Joseph S H Poetsch, Reza Neumann, Robert Fux, Stefan Schmiedel, Ansgar W Lohse, Bart L Haagmans, Gerd Sutter, Stephan Becker, Marylyn M Addo
Journal: The Lancet Infectious Diseases (2020)

The Middle East respiratory syndrome coronavirus (MERS-CoV) causes a respiratory disease with a case fatality rate of up to 35%. Given its potential to cause a public health emergency and the absence of efficacious drugs or vaccines, MERS is one of the WHO priority diseases warranting urgent research and development of countermeasures. We aimed to assess safety and tolerability of an anti-MERS-CoV modified vaccinia virus Ankara (MVA)-based vaccine candidate that expresses the MERS-CoV spike glycoprotein, MVA-MERS-S, in healthy adults.
Retrospective study of locally advanced bladder cancer in elderly patients
Authors: F. El Karak, G. Bringeon, G. Kepenekian, A. Flechon, M. Ghosn, J. Droz, C. Terret
Journal: Journal of Clinical Oncology (2006)

18523 Background: Bladder cancer is one of the most frequent tumors in elderly patients (pts). However, guidelines have not been established yet in this age group. Methods: We analyzed retrospectively pts aged 75 years or more, with muscle invasive or metastatic bladder cancer treated between January 2000 and June 2005, in three institutions in Lyon-France: Léon Bérard Center, Saint Luc Saint Joseph Hospital and Protestant Infirmary. Results: Data from 126 pts (81% male) were available: median age was 80 years (75–94). 99 pts had disease confined to the bladder, 19 confirmed metastatic cancer and 8 at least T2aM0 disease. 42% of pts had a history of superficial bladder cancer; 96% an urothelial carcinoma, 19% an associated in situ carcinoma. Of note, 33% of male pts had a concomitant prostate cancer. Median Performance Status, American Society of Anesthesia score and Charlson Comorbidity index were 1, 2 and 2.14 respectively. Cardiovascular comorbidities were the most common (42.8%). 87% of pts were taking medications; median number of drug intake was 4. We focused on pts with muscle invasive, non metastatic bladder cancer: 55 of 99 pts underwent surgery; 48 of them had external urinary diversion. Postoperative complications occurred in 34% of pts: evisceration (15%), sepsis, hemorrhage, acute cardiac failure, acute renal failure, pulmonary embolism (3.7% each), bowel obstruction and acute arterial thrombosis of lower limbs (1.8% each), and 2 immediate postoperative deaths. 16 pts received radiotherapy with a curative intent, 6 of them had chemoradiation. Mean irradiation dose and duration were respectively 56.4 Gy and 6.5 weeks. Toxicity occurred in 5 pts: 2 discontinuations for intolerance, 1 acute cardiac failure, 1 grade 3 thrombopenia, and 1 toxic death (intestinal perforation). The last 28 pts received palliative care. After a median follow up of 14 months, 33 operated pts and 3 pts treated by radiotherapy were still alive in complete remission. Disease free survival and median survival were 11.5 and 42 months in the surgical group respectively and 12 and 12 months in the radiotherapy group respectively. Conclusions: Treatment of locally advanced bladder cancer in the elderly carries significant morbidity and mortality. Oncogeriatric assessment benefit for individual management must be studied. No significant financial relationships to disclose.
Critical analysis of techniques and materials used in devices, syringes, and needles used for intravitreal injections
Authors: Gustavo Barreto Melo, Natasha Ferreira Santos da Cruz, Geoffrey Guy Emerson, Flávio Atanázio Rezende, Carsten H. Meyer, Susumu Uchiyama, John Carpenter, Hélio Francisco Shiroma, Michel Eid Farah, Maurício Maia, Eduardo Büchele Rodrigues
Journal: Progress in Retinal and Eye Research (2020)
Alterations in Smell or Taste in Mildly Symptomatic Outpatients With SARS-CoV-2 Infection
Authors: Giacomo Spinato, Cristoforo Fabbris, Jerry Polesel, Diego Cazzador, Daniele Borsetto, Claire Hopkins, Paolo Boscolo-Rizzo
Journal: JAMA (2020)

Michael Eliezer, MD; Charlotte Hautefort, MD; Anne-Laure Hamel, MD; Benjamin Verillaud, MD; Philippe Herman, MD, PhD; Emmanuel Houdart, MD, PhD; Corinne Eloit, MD
Abstract B30: Intratumoral microbes correlate with tumor-infiltrating lymphocytes in lung cancer RNAseq
Authors: Daniel Spakowicz, Rebecca Hoyd, YunZhou Liu, Janhavi Sahasrabudhe, Malvenderjit J. Singh, Isaac Arefi, Andrew Denney, David Carbone, Xiaokui Mo
Journal: Cancer Research (2020)

Abstract Nonhuman sequences have been found in many tumors, but their effect on outcomes remains poorly understood. We hypothesize that intratumoral microbes affect the recruitment of immune cells through local immunostimulatory effects including activation nucleic acid sensing pathways. We obtained RNA-seq data from 480 tumor biopsies including melanoma (16), bladder (104), colorectal (20), renal cell carcinoma (20), sarcoma (118), and lung (202) from patients treated at The Ohio State University Comprehensive Cancer Center as part of the Oncology Research Information Exchange Network (ORIEN). Reads were aligned to human and exogenous genomes using TopHat2 and Kraken2/Bracken, respectively. Human gene expression was deconvolved to absolute abundances of immune cells using CIBERSORT. An average of 99.87% of reads aligned to the human reference genome across all samples. Inferred counts of tumor-infiltrating lymphocytes (TILs), and particularly the immune cell types CD8+ T-cells and M1 macrophages, were significantly enriched in lung cancer relative to the other tested cancers (p-values &amp;lt;0.0001). TILs significantly correlated with both RIG-I and cGAS expression (p-values &amp;lt;0.0001). Exogenous reads aligned to 1328 genomes of bacteria, archaea, viruses, and fungi after filtering. The most abundant phyla within exogenous counts were the Proteobacteria (39.5%), Firmicutes (20.1%), and Actinobacteria (5.16%). Lung cancer samples showed positive correlations between Acinetobacter junii and CD8+ T-cells (p-value=0.035) and between Acidipropionibacterium virtanenii and activated NK cells (p-value=0.035). This suggests a mechanism by which intratumoral microbes may affect immune cell infiltration and cancer outcomes. Citation Format: Daniel Spakowicz, Rebecca Hoyd, YunZhou Liu, Janhavi Sahasrabudhe, Malvenderjit J. Singh, Isaac Arefi, Andrew Denney, David Carbone, Xiaokui Mo. Intratumoral microbes correlate with tumor-infiltrating lymphocytes in lung cancer RNAseq [abstract]. In: Proceedings of the AACR Special Conference on the Microbiome, Viruses, and Cancer; 2020 Feb 21-24; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2020;80(8 Suppl):Abstract nr B30.
A Phase 2 Study of Vorinostat (Suberoylanilide Hydroxamic Acid, SAHA) in Relapsed or Refractory Indolent Non Hodgkin Lymphoma. A California Cancer Consortium Study.
Authors: Mark H. Kirschbaum, Jasmine M. Zain, Leslie Popplewell, Vinod Pullarkat, Auayporn P. Nademanee, Maria L. Delioukina, Bernadette Pulone, Deron Matsuoka, Paul Frankel, Zwiebel A. James, Stephen J. Forman, Edward Newman, David Gandara
Journal: Blood (2007)
Congenital Amniotic Band Syndrome and MLL Rearranged Neonatal Leukemia in an Infant with Multiple Pre-Conception and In Utero Exposures.
Authors: Anna Sechser Perl, Blaine W. Robinson, Jaclyn A. Biegel, Elaine H. Zackai, Christos P. Kolaris, Carolyn A. Felix
Journal: Blood (2006)