tbuckley/cabot-search huggingface dataset:
Abstract P218: Fish Consumption is Not Associated With the Risk of Coronary Heart Disease or Stroke
Authors: Rachel E Ward, Kelly Cho, Rachel M Quaden, Xuan-Mai T Nguyen, Yuk-Lam Ho, Jason Vassy, David R Gagnon, Peter Wilson, J. Michael Gaziano, Luc Djousse
Journal: Circulation (2018)

Introduction: Many studies have shown an inverse association of omega-3 polyunsaturated fatty acid (PUFA) from fish intake and supplementation with coronary heart disease (CHD) mortality. However, findings on the relationship of omega-3 PUFA with nonfatal CHD and stroke are less consistent. Higher doses or prolonged intake may be needed to affect non-fatal cardiovascular events. We hypothesized that among Veterans, greater baseline fish intake is associated with a lower risk of nonfatal CHD and stroke, particularly among those who regularly use omega-3 supplements. Methods: The Million Veteran Program (MVP) is an ongoing nation-wide longitudinal cohort study of U.S. Veterans with self-reported survey, biospecimen, and electronic health record data. Participants who were free of CHD or stroke at the time of the baseline food frequency questionnaire were included in this analysis. Separate Cox proportional hazard models were used to assess the associations of fish intake with non-fatal incident CHD and stroke, defined from electronic health records using validated algorithms. Fish intake (serving=3-5 oz.) within the past year was categorized as &lt;1 serving/month, 1-3 servings/month, 1 serving/week, 2-4 servings/week, 5-6 servings/week, and 1+ serving/day. We assessed whether omega-3 fatty acid supplementation (yes/no) modifies these relationships by testing its interaction with fish intake. Multivariable models included demographics and known CHD and stroke risk factors: age, sex, race, smoking status, alcohol use, physical activity, education, overall dietary pattern, BMI, family history of CHD or stroke, and baseline diabetes, hypertension, and use of statins and fibrates. Results: Among 508,699 MVP participants to date, 210,180 (mean age 66±12 years, 92.1% male) were free of CHD or stroke and had data from the food frequency questionnaire at baseline. Median fish intake was 1 serving/week and 21.7% (45,552 out of 210,180) regularly took omega-3 supplements. Over a median follow-up of 2.9 years, there were 5,991 and 4,244 incident cases of non-fatal CHD and stroke, respectively. Using &lt;1 fish serving/month as the reference, multivariable adjusted HR (95% CI) for CHD were 0.99 (0.91-1.07) for 1-3 servings/month, 1.06 (0.98-1.15) for 1 serving/week, 1.06 (0.96-1.16) for 2-4 servings/week, 1.26 (1.03-1.53) for 5-6 servings/week, and 0.96 (0.68-1.34) for 1+ serving/day, (p-trend=0.08); corresponding values for stroke were 0.95 (0.87-1.05) for 1-3 servings/month, 0.96 (0.87-1.06) for 1 serving/week, 0.99 (0.88-1.11) for 2-4 servings/week, 1.05 (0.83-1.34) for 5-6 servings/week, and 1.23 (0.87-1.74) for 1+ serving/day, (p-trend=0.60). Intake of omega-3 fatty acid supplements did not modify the fish-CHD/stoke relations (p-interaction=0.32 and 0.82, respectively). Conclusions: We observed no consistent association between fish intake and non-fatal CHD or stroke.
THU0359 Relationship between damage clustering and mortality in juvenile systemic lupus erythematosus: cluster analyses in a large cohort from the spanish society of rheumatology lupus registry
Authors: J.M. Pego-Reigosa, T.C. Salman-Monte, I. Rua-Figueroa, J. Calvo-Alén, F.J. López-Longo, M. Galindo, A. Olivé, V. Torrente-Segarra
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Objectives</h3> Identify patterns (clusters) of damage manifestations within a large cohort of patients with juvenile-onset SLE (jSLE) and evaluate their potential association with mortality. <h3>Methods</h3> Multicenter, descriptive and cross-sectional study of a cohort of 345 patients with jSLE (age at SLE diagnosis &lt;18 years) from the Lupus Registry of the Spanish Society of Rheumatology (RELESSER). Organ damage was determined by using the SLICC/ACR damage index (SDI). By using cluster analysis, groups of patients with similar patterns of damage manifestations were identified and compared among them. <h3>Results</h3> Mean age (years)±S.D. at diagnosis was 14.2±2.89, 88.7% were female and 93.4% were Caucasian. Mean SLICC/ACR DI±S.D. was 1.27±1.63. A total of 12 (3.5%) patients died. Three damage clusters were identified: Cluster 1 (72.7% of patients) presented a lower amount of individuals with damage (22.3% vs 100% in clusters 2 and 3, p&lt;0.001). Cluster 2 (14.5% of patients) was featured by renal damage in 60% of patients, significantly more frequent than clusters 1 and 3 (p&lt;0.001), alongside more ocular, cardiovascular and gonadal damage. Cluster 3 (12.7%) was the only group with musculoskeletal damage (100%), significantly higher than in clusters 1 and 2 (p&lt;0.001). The overall mortality rate in cluster 2 was 2.2 times higher than that in cluster 3 and 5 times higher than that in cluster 1 (p&lt;0.017 for both comparisons). <h3>Conclusions</h3> In a large cohort of jSLE patients, renal and musculoskeletal damage manifestations were the two dominant forms of damage to sort patients into clinically meaningful clusters. We found two clusters of jSLE with important clinical damage that were associated to higher rates of mortality, especially for the cluster of patients with predominant renal damage. Physicians should pay special attention to the early prevention of damage in this particular subset of jSLE patients with kidney involvement. <h3>Disclosure of Interest</h3> None declared
Abstract P002: Black-White Differences in the Association of Neighborhood Socioeconomic Status with AHA’s Life’s Simple 7: The REasons for Geographic and Racial Differences in Stroke (REGARDS) Study
Authors: Virginia J Howard, George Howard, April P Carson, Shauntice Allen, Suzanne E Judd, Monika M Safford, Paul M Muntner, Leslie A McClure, Mary Cushman
Journal: Circulation (2016)

Introduction: The AHA’s Life’s Simple 7 (LSS) assesses cardiovascular health. Neighborhood socioeconomic status (N-SES) influences health; however, data are limited on racial differences in the association of N-SES and LSS. Hypothesis: Higher N-SES is associated with better LSS status similarly in whites and blacks. Methods: We studied 9,899 black and white participants aged 45+ without CVD from across the US. The 7 LSS metrics (blood pressure, cholesterol, glucose, BMI, smoking, physical activity, diet) were scored as poor, intermediate or ideal. N-SES was indexed by a composite score of 7 measures of wealth and education. The association of N-SES with both ideal health (vs intermediate or poor) and poor health (vs intermediate or ideal) was assessed adjusting for age and sex, and additional adjustment for individual SES (I-SES as income and education). Results: In whites, higher N-SES was associated with both higher ideal and lower poor status for 4 of the LSS metrics, with the remaining 3 associated with either higher ideal or lower poor status (figure). In blacks, only 1 LSS metric was associated with both higher ideal and lower poor status, 3 associated with either higher ideal or lower poor status, and there was no association in 3 metrics. After adjustment for I-SES, in whites N-SES remained associated with both higher ideal and lower poor status for 3 metrics, either higher ideal or lower poor in 3 metrics, and no association in 1 metric; however, in blacks, only 1 metric was associated with either ideal or poor status, no association for 5 metrics, and 1 metric with higher N-SES was associated with higher poor status. Conclusions: Higher N-SES was strongly associated with better LSS status in whites, even after adjustment for I-SES. However, the association between N-SES with better LSS status was much weaker in blacks, and was largely attenuated with adjustment for I-SES. With regard to LSS, place matters for whites, but plays a much smaller role for blacks.
AB1485-PARE Reumanifest: joining forces for political urgency
Authors: N Lopuhaä, M. Feith
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> In 2012, health insurance provisions for people with RMDs were cut drastically when reimbursement of physical therapy under the Dutch basic health insurance package was scrapped for reasons including lack of scientific evidence, the economic crisis and rising healthcare costs. The effect has been counterproductive. Costs have gone up as more patients use more medication and visit their rheumatologist and other specialists more often. It has also led to patients not getting the care they need. Because the Dutch Arthritis Foundation(DAF) believes that patients with RMDs should have access to the care they need, it launched a lobby to influence key governmental and political stakeholders. <h3>Objectives</h3> According to the DAF, patients with RMDs need access to the physical therapy they need. Efforts made in this area, such as the introduction of a registration point and impact research to demonstrate the effect of decreased accessibility, remained unsuccessful. We needed to adopt a different approach to instil in the government and political stakeholders a sense of urgency and to raise general awareness of the issue. <h3>Methods</h3> Parties in the field of RMD have now joined forces by: - consulting patients and care providers in a national survey: "Why is physiotherapy important to you?" - drafting a Reumanifest in which patients, doctors and researchers lobby for reinstatement of physiotherapy in the basic medical insurance package. - having the Reumanifest signed by patients, caregivers, professional organisations, professors, and other patient organisations (more than 25 000 responses). <h3>Results</h3> The Reumanifest was presented to political parties as a petition, and appeared in newspapers as an advertisement. This led to critical questions being asked to the Dutch Minister of Health, and put the issue and its urgency firmly back on the political agenda. With renewed political pressure on the issue, we expect that this will eventually lead to a solution for people with RMDs who need physiotherapy, but who now have to pay for this privately. The campaign has increased awareness among the cabinet and other political stakeholders. <h3>Conclusions</h3> By joining forces, you can make your voice heard in politics, as support from various perspectives lends credibility and relevance to the urgency. <h3>Disclosure of Interest</h3> None declared
THU0081 Identification of novel autoantibodies in the synovial fluid from patients with rheumatoid arthritis
Authors: K.-I. Goto, T. Kawamoto, A. Nakajima, M. Tahara, T. Ebata
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Rheumatoid arthritis (RA) is a chromic, autoimmune and inflammatory joint disease with a poorly understood etiology. Despite widespread diagnostic use of anti-citrullinated protein antibodies and rheumatoid factor, there is strong demand for novel biomarkers to improve the diagnosis this disease. <h3>Objectives</h3> The purpose of present study is to investigate novel autoantibodies in the synovial fluid of RA patients. <h3>Methods</h3> 1) By using SEREX (Serological identification of antigens by recombinant cDNA expression cloning), we identified ten and several antigens from sera of RA patients. 2) Three epitope sites in the candidate antigens proteins were predicted and 18 mer peptides were synthesised. 3) Synovial fluid of the knees was obtained from 48 RA and 48 osteoarthritis (OA) patients. 4) Furthermore, AlphaLISA was used to analyse the antibody levels in synovial fluid using synthetic polypeptide as antigens. <h3>Results</h3> Significantly higher proportion of antibodies against lamin A (LMNA, RA 19871+13924 VS OA 6726+3975, p&lt;0.0000001) and cell growth-regulating nucleolar protein (CGRN, RA 19673+13314 VS OA 10614+6391, p&lt;0.00007) were found in synovial fluid of RA as compared with OA. <h3>Conclusions</h3> We identified two novel autoantibodies in the knee synovial fluid of RA patients. These antibodies would have the potential to become diagnostic biomarkers of RA. <h3>References</h3> [1] Taimen P, Pfleghaar K, Shimi T, et al. A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization. Proc Natl Acad Sci U S2009;106:20788–93. [2] Su L, Hershberger RJ, and Weissman IL. LYAR, a nobel nucleolar protein with zinc finger DNA-binding mitifs, is involved in cell growth regulation. Genes Dev1993;7:735–48. <h3>Disclosure of Interest</h3> None declared
A Study of Haemostatic Parameters in Patients with Philadelphia-Negative Myeloproliferative Neoplasms. Correlation with, Clinical, Laboratory, Molecular, and Treatment Characteristics
Authors: Nefeli Giannakopoulou, Marianna Politou, Panagiotis Theodorou Diamantopoulos, Dimitris Korakakis, Maria Efstathopoulou, Theodora Kassi, Christina-Nefeli Kontandreopoulou, Katerina Zoi, Andreas Giannopoulos, Maria Dimou, Panayiotis Panayiotidis, Nora-Athina Viniou
Journal: Blood (2018)
Abstract 14133: Blood Pressure Lowering Less Than 130 mmHg is Best but Less Than 120 mmHg is Worst in a General Japanese Population
Authors: Hisako Tsuji, Ichiro Shiojima
Journal: Circulation (2016)

Background: The SPRINT trial reported the blood pressure (BP) lowering to 120 mmHg in some high-risk patients and meta-analyses supported intensive BP lowering. However, impact of BP lowering and a...
Cancer-Associated Thrombosis: Anatomic Distribution of the Index Event Is Not a Reliable Predictor of Recurrence Risk
Authors: Gerald A. Soff, Jeanette Batista, Debra M. M Sarasohn, Jodi V Mones, Cy Wilkins, Eva S Haegler-Laube, Sean M Devlin, Yimei Miao, Gemma Bendheim, Jonathan Wills, Simon H Mantha
Journal: Blood (2018)
A Feasibility and Safety Study of CD19 and CD22 Chimeric Antigen Receptors-Modified T Cell Cocktail for Therapy of B Cell Acute Lymphoblastic Leukemia
Authors: Junfang Yang, Jianqiang Li, Xian Zhang, Fanyong LV, Xiaoling Guo, Qinglong Wang, Lin Wang, Dandan Chen, Xiaosu Zhou, Jinhai Ren, Peihua Lu
Journal: Blood (2018)
Evolution of an X-Linked miRNA Family Predominantly Expressed in Mammalian Male Germ Cells
Authors: Fengjuan Zhang, Ying Zhang, Xiaolong Lv, Beiying Xu, Hongdao Zhang, Jun Yan, Haipeng Li, Ligang Wu
Journal: Molecular Biology and Evolution (2019)

MicroRNAs (miRNAs) are important posttranscriptional regulators of gene expression. However, comprehensive expression profiles of miRNAs during mammalian spermatogenesis are lacking. Herein, we sequenced small RNAs in highly purified mouse spermatogenic cells at different stages. We found that a family of X-linked miRNAs named spermatogenesis-related miRNAs (spermiRs) is predominantly expressed in the early meiotic phases and has a conserved testis-specific high expression pattern in different mammals. We identified one spermiR homolog in opossum; this homolog might originate from THER1, a retrotransposon that is active in marsupials but extinct in current placental mammals. SpermiRs have expanded rapidly with mammalian evolution and are diverged into two clades, spermiR-L and spermiR-R, which are likely to have been generated at least in part by tandem duplication mediated by flanking retrotransposable elements. Notably, despite having undergone highly frequent lineage-specific duplication events, the sequences encoding all spermiR family members are strictly located between two protein-coding genes, Slitrk2 and Fmr1. Moreover, spermiR-Ls and spermiR-Rs have evolved different expression patterns during spermatogenesis in different mammals. Intriguingly, the seed sequences of spermiRs, which are critical for the recognition of target genes, are highly divergent within and among mammals, whereas spermiR target genes largely overlap. When miR-741, the most highly expressed spermiR, is knocked out in cultured mouse spermatogonial stem cells (SSCs), another spermiR, miR-465a-5p, is dramatically upregulated and becomes the most abundant miRNA. Notably, miR-741−/− SSCs grow normally, and the genome-wide expression levels of mRNAs remain unchanged. All these observations indicate functional compensation between spermiR family members and strong coevolution between spermiRs and their targets.
AB0618 Prevalence of hypovitaminosis d in adults with systemic lupus erythematosus and the relationship with sledai 2k in patients treated in two rheumatology services, bogota 2017
Authors: R.A. Guzman Moreno, L.G. Piñeros, J. Garcia, L.M. Pombo, A. Teheran, J. Bustillo, K.A. Guzman Moreno, V. Cadavid, M.C. Mejia
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Vitamin D is a steroid hormone with pleiotropic effects on physiological processes. Among others, immune system regulation and their analogues prevent symptom development of autoimmune diseases such as SLE. A previous research in a colombian clinic found a prevalence of hipovitaminosis D of 87% in healthy population, but hypovitaminosis D is higher in SLE patients than healthy controls. <h3>Objectives</h3> To establish the prevalence of hypovitaminosis D in patients with SLE and relationship with SLEDAI – 2K. <h3>Methods</h3> A cross sectional study was carried out. 80 medical records with a diagnoses of SLE o CIE-10 M30-M36 were identified and we included patients&gt;18 years of age who meet at least 4 of the 11 criteria to diagnoses of SLE for medical record. The analysis included means, DS and Kruskall Wallis with p-value&lt;0.05. <h3>Results</h3> The majority of patients are women (94%), with an average age of 39.9 years, married (41%), with secondary education (56.7%) and different occupations. It was found that the patients with higher activity, had lower vitamin D levels. Additionally, if the patient had lupus nephritis, vitamin D levels decreased even more. <h3>Conclusions</h3> Patients with active systemic lupus Erythematosus, (SLE) have hypovitaminosis D more frequently and we noticed that patients with renal involvement have the lowest levels of vitamin D, which justifies a later analysis. <h3>References</h3> [1] American College of Rheumatology. Guidelines for referral and management of systemic lupus erythematosus in adults. Arthritis Rheum. 1999Sep;42(9):1785–96. [2] Simioni J, Heimovski F, Skare T. On lupus, vitamin D and leukopenia. 2016;56(3):206–211. [3] Guzman R.A, Piñeros L.G, Theran A, Flechas J, Mejía M. AB0795 Hypovitaminosis D and Calcium Intake of Adult Population in Bogota (DICAVITD). Ann Rheum Dis2016;75:1175–1176. [4] Alele J., et al. Autoimmun Rev2010;9:137–39. [5] Dall, era M., et al. in Kelley&amp;Firestein,s Textbook of Rheumatology. 10th Ed, Elsevier; Philadelphia 2017; 1368–89. <h3>Disclosure of Interest</h3> None declared
AB1445-HPR Patient satisfaction in a rheumatoid arthritis outpatient centre
Authors: L. Villarreal, D Buitrago-Garcia, F. Rodriguez, I. Mendez, P. Santos-Moreno
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Patient experience (PX) can be conceptualised as "the sum of all interactions, shaped by an organisation's culture, that influence patient perceptions, across the continuum of care" nowadays patient satisfaction is considered as one of the quality for performance in health systems(.<sup>1</sup> Rheumatology is mainly an outpatient, multidisciplinary medical specialty, therefore care does not stop at the diagnosis it continues during a long-term with frequent monitoring and patient participation.<sup>2</sup> <h3>Objectives</h3> Describe the results of a patient satisfaction survey in a specialised centre in. Colombia during 2017 <h3>Methods</h3> In our RA specialised centre during a 12 month period we performed a satisfaction survey in order to evaluate the health services provided. We evaluated the waiting times, timing on attention, appointment assignment, and information provided, the treatment received by the healthcare team, facilities among others. Patients evaluated the services provided in a scale from 1 to 5 were 1 was very bad, 2 bad, 3 regular 4 good and 5 very good. Descriptive epidemiology was performed for each variable presented. <h3>Results</h3> We performed 4756 surveys during 2017, 4550 surveys were completed with a 95% rate response, out of total 80% of respondents were female and 20% male. 80% of patients reported to receive their appointments on time; regarding the service provided by our health care professionals 99% of patients understood the indications regarding their treatment, 98% understood about the administrative procedures to program future appointments and to how to access to their medications, also 98% had clearly understood the date and time of their consultation (rheumatologist, physical therapist, nutritionist, psychologist, infusion therapy, among others.) The mean score for the overall assessment of the services was 4.2/5.0 (table 1). The average time of stay at our centre was 60 min±33. The main aspects to improve our patient satisfaction were the telephone programming of appointments, and the compliance regarding the delivery of medications. <h3>Conclusions</h3> This survey describes well-functioning multidisciplinary services for all patients who visit to our specialised centre. On the other hand although we found that our patients are highly satisfied, there is a large opportunity to improve our services and generate evidence regarding other aspects that involve the patient's health determinants. <h3>References</h3> [1] Th VP. Creating the ideal patient experience. Journal of medicine and life. 2016;9(4):380–5. [2] Vare P, Nikiphorou E, Hannonen P, Sokka T. Delivering a one-stop, integrated, and patient-centered service for patients with rheumatic diseases. SAGE open medicine. 2016;4:2050312116654404. <h3>Disclosure of Interest</h3> None declared