tbuckley/cabot-search huggingface dataset:
Abstract MP55: Associations Between Traffic-Related Air Pollution and Cardiovascular Disease Risk Factors Were Stronger in More Walkable Neighborhoods: The Cardiovascular Health in Ambulatory Care Research Team Cohort
Authors: Nicholas A Howell, Jack V Tu, Rahim Moineddin, Anna Chu, Hong Chen, Perry Hystad, Gillian L Booth
Journal: Circulation (2018)

Introduction: Studies suggest living in a more walkable neighborhood may protect against cardiovascular disease risk factors such as hypertension (HTN) and diabetes mellitus (DM) by encouraging physical activity. Walkable neighborhoods, however, often carry higher levels of traffic-related air pollution. Little is known regarding whether synergistic effects may exist between walkability and air pollution on these risk factors. Hypothesis: We hypothesized that the association between traffic-related air pollution, hypertension, and diabetes mellitus would be stronger in more walkable areas. Methods: We drew a cross-sectional sample of individuals ages 40-74 on January 1, 2008 from the CANHEART cohort. HTN and DM were ascertained using validated algorithms. Walkability (quintiles, Q5 highest, Q1 lowest) was measured using a validated index which has previously been shown to be inversely associated with obesity and diabetes. Exposure to nitrogen dioxide, a valid marker for traffic-related air pollution, was assessed using a land use regression models. The associations were tested using logistic regression with cluster-robust standard errors, adjusting for age, sex, area-level income, ethnicity, and comorbidities. Results: In total, 2,618,584 individuals were included in the analysis (mean (SD) age = 53.2 (9.2), 52% female). Walkability was inversely associated with odds for HTN (Q5 vs. Q1 OR = 0.80, 95% CI: 0.79, 0.82) and DM (Q5 vs. Q1 OR = 0.89, 95% CI: 0.87, 0.91), while NO 2 was positively associated with each (HTN: OR = 1.02 per 10 ppb (1.01, 1.03); DM: OR = 1.11 per 10 ppb (1.09, 1.13)). We observed significant interactions between walkability and NO 2 on odds for HTN and DM, with stronger NO 2 associations in the most walkable neighborhoods (Fig. 1). Conclusions: We observed significant interactions between traffic-related air pollution and walkability on odds for HTN and DM. This finding suggests that benefits from living in more walkable neighborhoods may be offset by stronger negative associations with air pollution.
Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages
Authors: Syed F. Hassnain Waqas, Anh Cuong Hoang, Ya-Tin Lin, Grace Ampem, Hind Azegrouz, Lajos Balogh, Julianna Thuróczy, Jin-Chung Chen, Ivan C. Gerling, Sorim Nam, Jong-Seok Lim, Juncal Martinez-Ibañez, José T. Real, Stephan Paschke, Raphaëlle Quillet, Safia Ayachi, Frédéric Simonin, E. Marion Schneider, Jacqueline A. Brinkman, Dudley W. Lamming, Christine M. Seroogy, Tamás Röszer
Journal: Journal of Clinical Investigation (2017)
Adult Neural Stem Cells and Multiciliated Ependymal Cells Share a Common Lineage Regulated by the Geminin Family Members
Authors: Gonzalo Ortiz-Álvarez, Marie Daclin, Asm Shihavuddin, Pauline Lansade, Aurélien Fortoul, Marion Faucourt, Solène Clavreul, Maria-Eleni Lalioti, Stavros Taraviras, Simon Hippenmeyer, Jean Livet, Alice Meunier, Auguste Genovesio, Nathalie Spassky
Journal: Neuron (2019)

Adult neural stem cells and multiciliated ependymal cells are glial cells essential for neurological functions. Together, they make up the adult neurogenic niche. Using both high-throughput clonal analysis and single-cell resolution of progenitor division patterns and fate, we show that these two components of the neurogenic niche are lineally related: adult neural stem cells are sister cells to ependymal cells, whereas most ependymal cells arise from the terminal symmetric divisions of the lineage. Unexpectedly, we found that the antagonist regulators of DNA replication, GemC1 and Geminin, can tune the proportion of neural stem cells and ependymal cells. Our findings reveal the controlled dynamic of the neurogenic niche ontogeny and identify the Geminin family members as key regulators of the initial pool of adult neural stem cells.
Response to Comment on Pongrac Barlovic et al. The Association of Severe Diabetic Retinopathy With Cardiovascular Outcomes in Long-standing Type 1 Diabetes: A Longitudinal Follow-up. Diabetes Care 2018;41:2487–2494
Authors: Drazenka Pongrac Barlovic, Valma Harjutsalo, Per-Henrik Groop
Journal: Diabetes Care (2019)

We are thankful for the response from Camoin et al. (1) to our article (2) showing the association of severe diabetic retinopathy (SDR) with cardiovascular disease, including peripheral artery disease, in long-standing type 1 diabetes. Importantly, the association was present even in the absence of DKD, a well-established risk factor for cardiovascular events and premature mortality (3). Results from the French cohort of patients with type 1 diabetes further strengthen the importance of SDR as a risk factor for lower-extremity ischemia, foot ulcers, and amputations. In their cohort ( n = 204) they were able to show an association between SDR and foot ulcers after adjustment for the presence of DKD and other cardiovascular risk factors, even with shorter diabetes duration (21 ± 13 years) and …
Defining the Functional Role of NaV1.7 in Human Nociception
Authors: Lucy A. McDermott, Greg A. Weir, Andreas C. Themistocleous, Andrew R. Segerdahl, Iulia Blesneac, Georgios Baskozos, Alex J. Clark, Val Millar, Liam J. Peck, Daniel Ebner, Irene Tracey, Jordi Serra, David L. Bennett
Journal: Neuron (2019)

Loss-of-function mutations in Na
Unifying Design and Analysis for Superiority and Noninferiority Trials With Appropriate End Point—Reply
Authors: Sergio A. Acuna, Fahima Dossa, Nancy N. Baxter
Journal: JAMA Surgery (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Update in Environmental and Occupational Medicine 2010
Authors: G. R. Scott Budinger, Gökhan M. Mutlu
Journal: American Journal of Respiratory and Critical Care Medicine (2011)

Large genome-wide association studies in patients with asthma, chronic obstructive pulmonary disease (COPD), and other major lung diseases have provided insight into the genetic determinants of disease (1, 2).However, the relatively small risk attributable to genetic variation observed in those studies has prompted investigators to renew their focus on the role of environmental exposures in the development of lung disease.Indeed, understanding how environmental exposures alter gene expression was identified as a major goal in a National Heart, Lung, and Blood Institute workshop report focused on understanding the link between genes and their function (3).The purpose of this update is to highlight the advances in environmental and occupational medicine published in the Journal over the past year in the broader context of the exciting ongoing work in this area.
Measuring the Integration of Stereotactic Ablative Radiotherapy Plus Surgery for Early-Stage Non–Small Cell Lung Cancer
Authors: David A. Palma, Timothy K. Nguyen, Alexander V. Louie, Richard Malthaner, Dalilah Fortin, George B. Rodrigues, Brian Yaremko, Joanna Laba, Keith Kwan, Stewart Gaede, Ting Lee, Aaron Ward, Andrew Warner, Richard Inculet
Journal: JAMA Oncology (2019)

Stereotactic ablative radiotherapy (SABR) is a standard treatment option in patients with medically inoperable early-stage non-small cell lung cancer (NSCLC), yet the pathologic complete response (pCR) rate after SABR is unknown. Neoadjuvant SABR in patients with cancer who are fit for resection has been hypothesized to improve local control and induce antitumor immune activity, potentially leading to better outcomes.To determine the pCR rate after SABR and to assess oncologic and toxicity outcomes after a combined approach of neoadjuvant SABR followed by surgery.A phase 2, single-arm trial, with patient accrual from September 30, 2014, to August 15, 2017 (median follow-up, 19 months), was performed at a tertiary academic cancer center. Patients 18 years or older with T1T2N0M0 NSCLC and good performance status, with adequate pulmonary reserve to undergo surgical resection, were studied.Patients underwent neoadjuvant SABR using a risk-adapted fractionation scheme followed by surgery 10 weeks later.The pCR rate as determined by hematoxylin-eosin staining.Forty patients (mean [SD] age, 68 [8] years; 23 [58%] female) were enrolled. Thirty-five patients underwent surgery and were evaluable for the primary end point. The pCR rate was 60% (95% CI, 44%-76%). The 30- and 90-day postoperative mortality rates were both 0%. Grade 3 or 4 toxic effects occurred in 7 patients (18%). In patients receiving surgery, 2-year overall survival was 77% (95% CI, 48%-91%), local control was 100% (95% CI, not defined), regional control was 53% (95% CI, 22%-76%), and distant control was 76% (95% CI, 45%-91%). Quality of life did not decline after treatment, with no significant changes in mean Functional Assessment of Cancer Therapy for Lung-Trial Outcome Index score during the first year of follow-up.The pCR rate after SABR for early-stage NSCLC was 60%, lower than hypothesized. The combined approach had toxic effects comparable to series of surgery alone, and there was no perioperative mortality. Further studies are needed to evaluate this combined approach compared with surgical resection alone.ClinicalTrials.gov identifier: NCT02136355.
Update in Pediatric Lung Disease 2012
Authors: Susanna A. McColley, Rory E. Morty
Journal: American Journal of Respiratory and Critical Care Medicine (2013)

In this article, we review publications especially relevant to pediatric pulmonologists, allergists, sleep medicine specialists, and neonatologists published in theAmerican Journal of Respiratory and Critical Care Medicine in 2012. Cystic fibrosis is excluded, as it is the topic of a separate Update (1). Additional asthma articles that may be of interest to pediatricians will be found in the Update in Asthma 2012 (2). Work published in the Journal during 2012 in the lung development and pediatrics arena has included discussion on the topical and controversial issues of alveolar regeneration in adults (3), has expanded upon previous work published in the Journal addressing susceptibility genes for bronchopulmonary dysplasia (BPD) (4), and has explored the growth of the pulmonary vasculature and the assessment of candidate prognostic factors in premature infants. The current interest in the pharmacological management of pediatric patients with glucocorticoids has been reviewed, as has the field of regenerative medicine.
Abstract 3980: Quantitative detection of discriminatory proteins in tissue and serum of ovarian cancer patients by LC-MSE
Authors: Wouter Wegdam, Gertjan Kramer, James Langridge, Perry D. Moerland, Shreyas M. de Jong, Johannes P. Vissers, Gemma G. Kenter, Marrije R. Buist, Johannes M.F.G. Aerts
Journal: Cancer Research (2010)

Abstract Purpose To search for potential protein markers or activated pathways which play a role in ovarian cancer. Experimental procedures Serum of six patients with a serous adenocarcinoma of the ovary (stage IIIB or higher) was collected before treatment. Matched control patients with a serous cystadenoma of the ovary were chosen as a control group. In addition, homogeneous regions of cells that exhibited uniform histology were isolated from cancer tissue in three of these patients by laser capture microdissection (LCM), normal ovarian epithelial cell samples were taken from their matched controls. Subsequently we employed label-free liquid chromatography tandem mass spectrometry (LC-MSE) to identify proteins and determine their absolute concentrations in serum specimens and tissue lysates. Moderated t-tests were used to identify differentially expressed proteins between patient- and control-group, p-values were adjusted for multiple-testing using Benjamini-Hochberg false discovery rates. Proteins were considered to be differentially expressed if the adjusted p-values were &amp;lt;0.05. Summary of the data In the serum specimens, 13 differentially expressed proteins were identified by LC-MSE profiling. Proteins with different concentrations in patients versus control sera include abundant serum proteins such as apolipoprotein AI and transferrin, that both exhibited a lower concentration in serum of cancer patients. Differential expression was also observed for apolipoproteins (APOA IV, APOA II and APOC III) and other proteins that have not been associated with ovarian cancer previously such as C9 and Afamin. In the tissue lysates, 17 differentially expressed proteins were identified. Amounts of collagen found were decreased in cancer tissue. Furthermore, proteins associated with the respiratory chain and cell migration were found in increased amounts in the cancer tissue lysates. Interestingly, no overlap was found between the discriminatory proteins in serum specimens and corresponding tissue lysates, illustrating the challenge to identify a single biomarker in the circulation reflecting ovary cancer. Conclusions Our study revealed several protein changes in serum and the ovary of patients suffering from serous adenocarcinoma of the ovary (stage IIIB or higher). Further investigation of these proteins is warranted to establish whether they could provide new insights into the etiology of the disease and act as potential new disease markers. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3980.
Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion
Authors: Isaac S. Harris, Jennifer E. Endress, Jonathan L. Coloff, Laura M. Selfors, Samuel K. McBrayer, Jennifer M. Rosenbluth, Nobuaki Takahashi, Sabin Dhakal, Vidyasagar Koduri, Matthew G. Oser, Nathan J. Schauer, Laura M. Doherty, Andrew L. Hong, Yun Pyo Kang, Scott T. Younger, John G. Doench, William C. Hahn, Sara J. Buhrlage, Gina M. DeNicola, William G. Kaelin, Joan S. Brugge
Journal: Cell Metabolism (2019)
Clinical highlights from the National Cancer Data Base, 2000
Authors: A. K. Stewart, K. I. Bland, L. S. McGinnis, M. Morrow, H. J. Eyre
Journal: CA A Cancer Journal for Clinicians (2000)

The National Cancer Data Base (NCDB) is the empirical data collection and analysis arm of the American College of Surgeons Commission on Cancer, and is supported in part by the American Cancer Society. The NCDB collects oncology patient demographic information, diagnostic and treatment information, and outcomes data from a broad spectrum of hospital-based cancer registries throughout the US, ranging from large research and teaching facilities to small community hospitals. Through this unique network, data are aggregated and reported back to participating hospitals to allow individual facilities to evaluate local patient care practices and outcomes. This article highlights the principal findings of articles published in 1999 and early 2000 that used NCDB data as the empirical basis of their analyses. Included among these are articles on breast cancer, gastric carcinoma, head and neck cancers, leukemia, liver carcinoma, lung cancer, parathyroid tumors, prostate carcinoma, small bowel adenocarcinoma, testicular malignancies, and vulvar melanoma. These articles are based on cases diagnosed between 1985 and 1996. The NCDB has accrued more than 6.4 million cancer cases for this time period. Sufficient numbers of rare cancers are reported to the NCDB to permit some types of clinical evaluation not possible using other data sources.
Expression Profile of VEGF and VEGFR2 in the Female Reproductive Tract at the Time of Placentation in a Porcine Model of Von Willebrand Disease Type 1
Authors: Mario von Depka, Mahnaz Ekhlasi-Hundrieser, Carsten Detering, Stefanie Lehner, Christiane Pfarrer, Hanna Allerkamp
Journal: Blood (2018)
Abstract 2729: Quantitative cell-based bioassays to advance individual or combination immune checkpoint immunotherapy
Authors: Jamison Grailer, Julia Gilden, Pete Stecha, Denise Garvin, Jim Hartnett, Frank Fan, Mei Cong, Zhi-Jie Jey Cheng
Journal: Cancer Research (2018)

Abstract Immune checkpoint receptors play a critical role in maintaining immune homeostasis and are genetically and functionally associated with autoimmune disease, cancer and persistent viral infections. Blockade of immune checkpoints has emerged as a promising new approach to enhance anti-tumor immune responses. After initial successes with PD-1 and CTLA-4-targeted therapies, immunotherapy research has broadened to include additional immune checkpoint receptors targeted individually or in combination. A significant challenge in the development of biologics that target immune checkpoints is access to quantitative and reproducible functional bioassays. Existing methods rely on primary cells and measurement of complex functional endpoints. As an alternative to primary cell assays, we have developed a panel of cell-based reporter bioassays that can quantitatively determine the potencies of biologics targeting the immune checkpoints PD-1, CTLA-4, LAG-3, TIM-3, TIGIT, and BTLA, or bispecific antibody or antibody cocktails targeting two immune checkpoint receptors such as PD-1+TIGIT, PD-1+LAG-3, and PD-1+CTLA-4. These assays consist of engineered T effector cells that express luciferase reporters driven by specific response elements integrating signaling from the T cell receptor and immune checkpoint target(s), and engineered artificial antigen presenting cells. These mechanism of action-based bioassays demonstrate high specificity, sensitivity and reproducibility. Therefore they can serve as valuable tools for immunotherapy drug development. Citation Format: Jamison Grailer, Julia Gilden, Pete Stecha, Denise Garvin, Jim Hartnett, Frank Fan, Mei Cong, Zhi-Jie Jey Cheng. Quantitative cell-based bioassays to advance individual or combination immune checkpoint immunotherapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 2729.
Stand by me(mory): Chronic infection diminishes memory pool via IL-6/STAT1
Authors: Philipp A. Lang, Karl S. Lang
Journal: The Journal of Experimental Medicine (2019)

Despite great efforts to eradicate chronic viral infections, they still remain a global health problem. In this issue, Barnstorf et al. (2019. J. Exp. Med. https://doi.org/10.1084/jem.20181589) show that virus-unspecific bystander memory T cells are highly affected during chronic viral infection via IL-6/STAT1. Bystander memory T cells are strongly decimated in numbers and change in phenotype and function during chronic viral infection. These data provide new explanations for immune-mediated problems during chronic virus infections.
microRNA-16-5p enhances radiosensitivity through modulating cyclin D1/E1–pRb–E2F1 pathway in prostate cancer cells
Authors: L. Gan, F. Wang
Journal: Annals of Oncology (2019)

Background: Prostate cancer (CaP) was the second most common cancer in men worldwide in 2012, and radiation therapy is one of the most common definitive treatment options for localized CaP. However, radioresistance is a major challenge for current radiotherapy, accumulating evidence suggests microRNAs (miRNAs), as an important regulator in cellular ionizing radiation (IR) responses, are closely correlated with radiosensitivity in many cancers. Methods: We performed human miRNA probe hybridization chip analysis to identify the expression profile of miRNAs in CaP cells exposed to IR, and then we analysed the cell proliferation, cell viability, and cell cycle after transfection of miR-16-5p into the CaP cells. Analysis of the cyclin D1/E1–pRb–E2F1 pathway related proteins were performed by western blotting. Results: microRNA- 16-5p (miR-16-5p) is significantly upregulated in CaP LNCaP cells following IR and can enhance radiosensitivity through modulating the cyclin D1/E1–pRb–E2F1 pathway. Overexpression of miR-16-5p suppressed cell proliferation, reduced cell viability, and induced cell cycle arrest at G0/G1 phase, resulting in enhanced radiosensitivity in LNCaP cells. Additionally, miR-16-5p specifically targeted the cyclin D1/E1-3′-UTR in LNCaP cells and affected the expression of cyclin D1/E1 at both mRNA and protein levels. Conclusions: miR-16-5p enhanced radiosensitivity of CaP cells, the mechanism may be through modulating the cyclin D1/cyclin E1/pRb/E2F1 pathway to cause cell cycle arrest at G0/G1 phase. These findings provided new insight into the correlation between miR-16-5p, cell cycle arrest, and radiosensitivity in CaP, revealed a previously unrecognized function of miR-16-5p–cyclin D1/E1–pRb–E2F1 regulation in response to IR and may offer an alternative therapy to improve the efficiency of conventional radiotherapy. Legal entity responsible for the study: Institute of Modern Physics, Chinese Academy of Sciences. Funding: Has not received any funding. Disclosure: All authors have declared no conflicts of interest.
CRISPR Activation Screen for HDAC Inhibitor Resistance
Authors: Huihui Tang, Ricardo De Matos Simoes, Ryosuke Shirasaki, Olga Dashevsky, Brian Glassner, Sondra L. Downey-Kopyscinski, Sara Gandolfi, Michal Sheffer, Megan Bariteau, John G Doench, Constantine S. Mitsiades
Journal: Blood (2018)
Association of Outcome Definitions With Success Following Adrenalectomy for Primary Aldosteronism
Authors: Heather Wachtel, Rachel R. Kelz
Journal: JAMA Surgery (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal