FRI0305 FERTILITY AND PREGNANCY OUTCOMES IN WOMEN WITH SPONDYLOARTHRITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: S. Hamroun, A. Hamroun, J. J. Bigna, E. Allado, F. Förger, A. Moltó
Journal: Annals of the Rheumatic Diseases (2020)

Background: Women with spondyloarthritis (SpA) are often affected by the disease during their reproductive years 1 . However, little is known about the impact of the disease and its treatments on fertility and pregnancy outcomes, as well as the effect of pregnancy itself on disease activity 2 . Objectives: The aim of the study was to determine the effects of spondyloarthritis on fertility and pregnancy outcomes in women with SpA. Methods: We searched Pubmed, Embase, and Web of Science until 1 November 2019, without any language restriction. All studies assessing fertility, pregnancy outcomes and disease activity during pregnancy in women with spondyloarthritis (axial SpA (axSpA) but also peripheral SpA, including psoriatic arthritis (PsA)) were eligible. The heterogeneity between studies was quantified (I 2 ), and multiple meta-regressions were carried out to identify potential sources of heterogeneity. In case I 2 was &lt; 50%, a random-effects model was used to pool the available data. Prevalence of events was described as percentages. The odds ratio (OR) and corresponding 95% confidence interval (CI) were used to assess the associations between the disease and the pregnancy outcomes. Results: Within 4397 eligible studies, 21 articles fulfilling the selection criteria were included in the review, assessing overall 3306 patients (2578 with axSpA and 728 with PsA) and 4104 pregnancies compared to 42248 healthy controls (in 11 studies with a control group). Among the included studies, the risk of bias was evaluated as high, moderate and low in respectively 12, 1 and 8 studies. Regarding pregnancy outcomes, several studies report an increased risk of preterm birth, small for gestational age (pooled OR 2,05, [1,09-3,89], I 2 =5,8% in axSpA) and caesarean section (pooled OR 1,77 [1,45-2,17], I 2 =27,5% in axSpA and pooled OR 1,47 [1,22-1,76], I 2 =0,0% in PsA), without any other unfavourable pregnancy outcome (miscarriage, stillbirth, gestational diabetes or preeclampsia). Further analysis found a significant higher risk for elective caesarean (pooled OR 2,64, [1,92-3,62], I 2 =0,0% in axSpA and pooled OR 1,47, [1,15-1,88], I 2 =0,0% in PsA), without increased risk for emergency caesarean. There was no substantial heterogeneity in the majority of meta-analyses. Conclusion: Although based on observational data, this work is to our knowledge, the first systematic review and meta-analysis concerned with this subject. SpA and PsA seem to be associated with an increased risk of preterm birth, small for gestational age and elective caesarean section. The analysis of the impact of pregnancy on disease activity in this setting is currently ongoing. References: [1]Van den Brandt S. Arthritis Res Ther 2017;19(1):64. [2]Ursin K. Rheumatology. 201;57(6):1064-1071. Fig. 1. Association between caesarean section and axSpA Fig. 2. Association between small for gestational age and axSpA Disclosure of Interests: SABRINA HAMROUN: None declared, Aghilès Hamroun: None declared, Jean Joël Bigna: None declared, Edem Allado: None declared, Frauke Förger Grant/research support from: Unrestricted grant from UCB, Consultant of: UCB, GSK, Roche, Speakers bureau: UCB, GSK, Anna Moltó Grant/research support from: Pfizer, UCB, Consultant of: Abbvie, BMS, MSD, Novartis, Pfizer, UCB