tbuckley/cabot-search huggingface dataset:
AB0242 Delay in dmard initiation in patients newly diagnosed with rheumatoid arthritis: an analysis of united states military health system beneficiaries
Authors: L. Kimsey, J.S. Weissman, A. Patel, A. Drew, T. Koehlmoos, J.A. Sparks
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Prompt initiation of disease-modifying antirheumatic drugs (DMARDs) is recommended for patients diagnosed with rheumatoid arthritis (RA) to improve symptoms and prevent disease progression, but treatment delays may still occur. <h3>Objectives</h3> To investigate predictors and temporal trends for delay in DMARD initiation among patients with incident RA in the United States. <h3>Methods</h3> We performed a longitudinal cohort study using administrative data from the United States military's TRICARE program (2007–2012). TRICARE beneficiaries, who are demographically similar to the US, include active/retired military members, spouses, and dependents and receive care in military or civilian settings. We identified incident RA cases using billing codes and initial DMARD receipt using prescription fill date. We quantified the time between RA presentation and initial DMARD receipt, temporal changes in time to treatment over the study period, and investigated predictors of treatment delay (&gt;90 days) using logistic regression. <h3>Results</h3> We identified 16 680 patients with incident RA that were later prescribed DMARDs. Mean age was 47.2 (SD 13.5) years, 77.6% were female, and 76.5% were spouses/dependents of the military sponsor. The mean time from initial RA presentation to first DMARD prescription was 125.3 days (SD 175.4). Over one-third (35.6%) of incident RA patients experienced treatment delay (&gt;90 days between presentation and DMARD receipt). Time to DMARD initiation was shorter in later years of the study (mean 144.7 days in 2007; 109.7 days in 2012). Patients prescribed opioids between RA presentation and initial DMARD receipt had 4-fold increased risk for delay in initial DMARD (OR 4.07, 95% CI 3.78–4.37). Patients prescribed opioids had mean time to DMARD of 212.8 days (SD 207.4) compared to mean of 77.3 days (SD 132.3) for those who did not use opioids (p&lt;0.0001). Use of prescription NSAIDs between initial RA presentation and DMARD initiation was also associated with delay (OR 3.32, 95% CI 3.09–3.57). Men were less likely than women to experience delay (OR 0.89, 95% CI 0.82–0.98). <h3>Conclusions</h3> In this large US nationwide study, delays in initial DMARD receipt after incident RA were common but time to treatment improved in later years of the study. Avoiding opioid use may decrease delay in initiating DMARDs during this vulnerable period when pain and disease activity are often most pronounced. <h3>Disclosure of Interest</h3> None declared
AB0818 The comparative study of systemic sclerosis and systemic lupus erythematosus-associated pulmonary arterial hypertension
Authors: Y. Feng, J. Wang, Y. Lei, X. Zhang
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Systemic Sclerosis(SSc) is the main cause of Connective Tissue Disease-associated pulmonary arterial hypertension (CTD-PAH) in western countries, while Systemic Lupus Erythematosus(SLE) is the first cause in Asian. Systemic Sclerosis(SSc) is the main cause of Connective Tissue Disease-associated pulmonary arterial hypertension (CTD-PAH) in western countries, while Systemic Lupus Erythematosus(SLE) is the first cause in Asian. <h3>Objectives</h3> This study aimed to identify the clinical difference between SSc-PAH and SLE-PAH. This study aimed to identify the clinical difference between SSc-PAH and SLE-PAH. <h3>Methods</h3> SSc and SLE patients with pulmonary arterial hypertension who visited Guangdong General Hospital in China from 2009 to 2017 were recruited. PAH was diagnosed by transthoracic echocardiography or right heart catheterization and clinical data of patients was collected. Comparative study between SSc-PAH and SLE-PAH was conducted to identify the difference. SSc and SLE patients with pulmonary arterial hypertension who visited Guangdong General Hospital in China from 2009 to 2017 were recruited. PAH was diagnosed by transthoracic echocardiography or right heart catheterization and clinical data of patients was collected. Comparative study between SSc-PAH and SLE-PAH was conducted to identify the difference. <h3>Results</h3> Twenty-nine SSc-PAH and 55 SLE-PAH patients were enrolled. The baseline characteristics of two groups was shown in table 1. In comparative study: the gender(p=0.018), the age of PAH diagnosis(p=0.001), Raynaud's phenomenon(p&lt;0.001), WHO function state(p=0.019), PASP (p=0.013), the diameter of RA(p=0.045) and RV(p=0.029) showed significant difference between SSc and SLE-PAH. <h3>Conclusions</h3> The SSc-PAH patients tent to be older, have more angiopathic characteristics and more silent clinical course than SLE patients, which might bring some insight into the different pathophysiological process between SSc and SLE-PAH. The SSc-PAH patients tent to be older, have more angiopathic characteristics and more silent clinical course than SLE patients, which might bring some insight into the different pathophysiological process between SSc and SLE-PAH. <h3>Disclosure of Interest</h3> None declared
AB1320 Clinical, immunological and expositional factors in a colombian population with systemic lupus erythematosus associated with lupus nephritis
Authors: J.C. Diaz-Coronado, A. Rojas-Villarraga, D. Hernandez Parra, L. Betancur-Vasquez, J. Lacouture-Fierro, D. Gonzalez-Hurtado, J. Gonzalez- Arango, L. Uribe- Arango, M.C. Gaviria-Aguilar, P. Perez-Estrada, M.C. Soto-Osorio, R. Pineda-Tamayo
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by multiple organ involvement, lupus nephritis (LN)<sup>1</sup> being one of the most serious manifestations <h3>Objectives</h3> To establish associated factors with lupus nephritis development in patients with SLE <h3>Methods</h3> Cross-sectional study taken from a cohort of 1175 patient with SLE who met criteria for classification for <sup>ACR 1997</sup> or ,<sup>SLICC 2012</sup> between 2007 and 2015. Bivariate analysis of multiple characteristics was performed between patients with presence and absence of LN at through chi squared and U Mann Whitney. Multivariate analysis was performed by logistic regression to adjust for significant associations <h3>Results</h3> The cohort of patients with SLE 90% was female gender, had an average of 44 years with a duration of the disease of 10.6 years. Joint and haematological involvement was present in more than 80% of patients. The presence of antibodies against DNA and low complement was found in 53% and 60% respectively. The exposure to dyes was 44% and tobacco 21%. It was found 455 patients with SLE and LN with an average age of 41 years and a time of evolution of SLE of 11 years. The male gender proportion was higher in those who presented LN with 11.6% compared to 7.1% who did not have LN. The immunological profile of patients with NL was characterised by a higher proportion of positivity for Anti-DNA, anti-SM and low complement. Male gender has a greater association with LN (OR 1.98 CI 95% 1,20–3,27). Having a disease duration greater than 10 years increases the association with LN (OR 1.48 95% CI 1–2,16) as well as the presence of anti-DNA (OR 1.34 CI95% 1,03–1,75) and antiSM (OR 1.45 95% CI 1.04–2.02). Never smoker was a protective factor for LN (OR 0.52 CI95% 0.34–0.81). <h3>Conclusions</h3> This study shows a greater association of LN in men. Although there are disparities in the findings worldwide, we believe that other factors typical of this current population such as ancestry and racial mixing may be influencing this finding. No smoking seems to be a protective factor. Awareness of the disclosed risk factor should encourage preventive strategies for LN in SLE patients such as suppression of cigarette smoking. <h3>References</h3> [1] Pons-estel GJ, Catoggio LJ, Cardiel MH, Bonfa E, Caeiro F, Sato E, et al. Lupus in Latin-American patients: lessons from the GLADEL cohort. 2015;536–45 [2] V. A. Seligman, R. F. Lum JLO. Demographic Differences in the Development of Lupus Nephritis: A Retrospective Analysis. Am J Med. 2002;9343(2):726–9. <h3>Disclosure of Interest</h3> None declared
ACC1 determines memory potential of individual CD4+ T cells by regulating de novo fatty acid biosynthesis
Authors: Yusuke Endo, Atsushi Onodera, Kazushige Obata-Ninomiya, Ryo Koyama-Nasu, Hikari K. Asou, Toshihiro Ito, Takeshi Yamamoto, Toshio Kanno, Takahiro Nakajima, Kenji Ishiwata, Hirotaka Kanuka, Damon J. Tumes, Toshinori Nakayama
Journal: Nature Metabolism (2019)
SAT0697 Association between tonsillitis and newly diagnosed ankylosing spondylitis: a nationwide, population-based, case-control study
Authors: H.-H. Chen, W.-C. Chao, D.-Y. Chen
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> To date, two most commonly proposed environmental risk factors for ankylosing spondylitis (AS) include mechanical stress at the enthesis and infections. A recent Swedish study showed that childhood tonsillitis was associated with future development of AS. However, no Ascian study has reported this association. <h3>Objectives</h3> To investigate the association between tonsillitis and the risk of newly diagnosed AS. <h3>Methods</h3> We used 2003–2012 data from the Taiwanese National Health Insurance Database to perform a nationwide, population-based, case-control study. We identified AS patients newly diagnosed from 2005 to 2012 as the study group and selected sex, age and the year of index date matched (1:6) non-AS individuals as controls. Using conditional logistic regression analysis after adjustment for potential confounders, including a history of periodontitis, appendicitis, and Charlson comorbidity index (CCI), we measured the association of AS risk with prior tonsillitis by calculating odds ratios (ORs) with 95% confidence intervals (CIs). Sensitivity analyses for the association between AS risk and tonsillitis were conducted by varying the definition of tonsillitis. <h3>Results</h3> We identified 37 002 incident AS cases and 2 22 012 matched non-AS controls. The risk of AS was associated with tonsillitis (OR, 1.80; 95% CI, 1.55–2.10) after adjustment for potential confounders. The association between AS risk and a history of tonsillitis remained significant by using various definitions of tonsillitis based on ICD9-CM Codes. Such associations were consistent across various subgroups stratified by age, sex, and a history of periodontitis or appendicitis. <h3>Conclusions</h3> The present study reveals an association between AS risk and prior tonsillitis. <h3>Reference</h3> [1] Lindstrom U, Exarchou S, Lie E, Dehlin M, Forsblad-d'Elia H, Askling J, Jacobsson L. Childhood hospitalisation with infections and later development of ankylosing spondylitis: a national case-control study. Arthritis research &amp; therapy2016;18:240. <h3>Acknowledgements</h3> We would like to thank the Biostatistics Task Force of Taichung Veterans General Hospital, Taichung, Taiwan, ROC, for assistance with statistical analysis. <h3>Disclosure of Interest</h3> None declared
Immunostimulatory Effects Triggered by Self‐Assembled Microspheres with Tandem Repeats of Polymerized RNA Strands
Authors: Dajeong Kim, Hyejin Kim, Sangwoo Han, Marta Scatena, Deok‐Ho Kim, Jong Bum Lee
Journal: Advanced Healthcare Materials (2019)

Abstract Self‐assembled RNA particles have been exploited widely to maximize the therapeutic potential of RNA. However, the immune response via RNA particles is not fully understood. In addition, the investigation of the immunogenicity from RNA‐based particles is required owing to inherent immunostimulatory effects of RNA for clinical translation. To examine the immune stimulating potency, rationally designed microsized RNA particles, called RNA microspheres (RMSs), are generated with single or double strands via rolling circle transcription. The RMSs show an exceptional stability in the presence of serum, while they are selectively degraded under endolysosomal conditions. With precisely controlled size, both RMSs are successfully taken up by macrophages. Unlike the nature of RNA fragments, RMSs induce only basal‐level expression of inflammatory cytokines as well as type I interferon from macrophages, suggesting that RMSs are immunocompatible in the therapeutic dose range. Taken together, this study could help accelerate clinical translation and broaden the applicability of the self‐assembled RNA‐based particles without being limited by their potential immunotoxicity, while a systematic controllability study observing the release of RNA fragments from RMSs would provide self‐assembled RNA‐based structures with a great potential for immunomodulation.
FRI0650 The diagnostic value of the aeskulisa pr3 sensitive &amp; aeskulisa mpo in the euvas-cohort
Authors: K. Prager, N. Marte, E. Csernok, A. Lerner, T. Matthias
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background:</h3> Anti-neutrophil-cytoplasmic-antibodies directed against proteinase-3 (PR3-ANCA) and myeloperoxidase (MPO-ANCA) are serological hallmarks of small vessel vasculitis, particularly granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). In a recent multicentre European-Vasculitis-Study-Group (EUVAS) evaluation, the performance of IIF was compared to that of various antigen-specific immunoassays. <h3>Objectives:</h3> The aim was to evaluate the diagnostic accuracy of the third-generation antigen-specific immunoassays PR3-ANCA (AESKULISA-PR3-sensitive) and MPO-ANCA (AESKULISA-MPO) and to compare these data with the results from the other assay (Orgentec). <h3>Methods:</h3> 257 samples from the EUVAS cohort were tested for the presence of ANCA by PR3-ANCA ELISA (AESKULISA-PR3-sensitive) and MPO-ANCA ELISA (AESKULISA-MPO). Newly diagnosed GPA/MPA (n=66) patients and diseased controls (n=191): systemic lupus erythematosus (n=60), systemic sclerosis (n=10), rheumatoid arthritis (n=90), Scleroderma (n=11) and Sjögren's syndrome (n=30) were analyzed. <h3>Results:</h3> In AAV patients, ANCAs were detected with both methods in 56 cases; divergent results were obtained in only 1 patient sample. 191 patients with other rheumatic diseases were analyzed and only 13 vs 11 (AESKU/Orgentec) were positive for ANCA (SLE, sclerosis, RA, RA/RV). This study shows that the PR3- and MPO-ANCA ELISA are highly specific (93.2%/94.2%) and sensitive (85.9%/85.9%) in the detection of ANCA to identify AAV or conditions known to be associated ANCA. <h3>Conclusions:</h3> Our comparison of PR3- and MPO-ANCA ELISAs showed (i) a high diagnostic performance of these PR3- and MPO-ANCA ELISAs to discriminate AAV from disease controls. (ii) very good correlation between the other methods tested. In conclusion, these novel assays can be used as screening method for detection of ANCA-associated diseases. <h3>Disclosure of Interest:</h3> None declared
The Oculome Panel Test
Authors: Aara Patel, Jane D. Hayward, Vijay Tailor, Rodney Nyanhete, Helena Ahlfors, Camila Gabriel, Tommaso B. Jannini, Yassir Abbou-Rayyah, Robert Henderson, Ken K. Nischal, Lily Islam, Maria Bitner-Glindzicz, Jane Hurst, Leonardo E. Valdivia, Mario Zanolli, Mariya Moosajee, John Brookes, Maria Papadopoulos, Peng T. Khaw, Thomas Cullup, Lucy Jenkins, Annegret Dahlmann-Noor, Jane C. Sowden
Journal: Ophthalmology (2019)
Abstract 12282: A Nationwide Study on the Predictors of In-hospital Mortality Among Patient With Heart Failure Receiving an Intra-aortic Balloon Pump
Authors: Ahmed M Mahmoud, Ali Abbas, Peter Draganov, Juan Aranda
Journal: Circulation (2015)

Background: Intra-aortic balloon pump (IABP) is an important treatment modality for patients with cardiogenic shock. However, little information is known about the actual incidence and predictors of in-hospital mortality following IABP placement. Methods: Using the National Inpatient Sample database 2009-2011, all adult patients with admission diagnosis codes of congestive heart failure and procedure codes for IABP were identified. Patients who underwent LVAD or OHT placement off IABP were excluded from the analysis. Information about demographics, insurance, year of admission, hospital characteristics, comorbidities and acute in hospital complications were abstracted from the database. Using in-hospital death as our outcome, variables that achieved statistical significance (p &lt;0.05) using Chi square testing were included in a multivariable analysis. Results: A total of 75,744 patients were diagnosed with congestive heart failure and had IABP placement from 2009 till 2011. The mean age was 66 years. The patient’s demographics revealed a higher incidence of IABP placement in Caucasian patients (64.3%) compared to other racial minorities. The majority of IABP placement occurred in urban hospitals (94.9%) with higher number of IABP placement in teaching (56.7%) compared to non-teaching hospitals (43.3%). The overall mortality rate following IABP placement was 20%. By multivariate analysis, the presence of acute kidney injury (AKI) requiring hemodialysis was associated with the highest risk of in-hospital death; other predictors of mortality are shown in Table 1. In a subgroup analysis, predictors of mortality did not differ for patients with or without myocardial infaction. Conclusion: In this nationwide analysis, overall in-hospital mortality was high occurring in 20% of the patients following IABP placement. The presence of older age, AKI, DIC, GIB and DIC are associated with worse outcome following IABP placement.
Basophil-derived tumor necrosis factor can enhance survival in a sepsis model in mice
Authors: Adrian M. Piliponsky, Nicholas J. Shubin, Asha K. Lahiri, Phuong Truong, Morgan Clauson, Kerri Niino, Avery L. Tsuha, Sergei A. Nedospasov, Hajime Karasuyama, Laurent L. Reber, Mindy Tsai, Kaori Mukai, Stephen J. Galli
Journal: Nature Immunology (2019)
AB0989 The impact of a low-cost digital and print awareness campaign on patient behaviour in relation to personal risk of osteoporosis and fragility fracture
Authors: H. Mace, C. Bovey, H. Arden, T. Jones
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> The National Osteoporosis Society (NOS) 'Stop at One' campaign aims to encourage people who are over 50 and have broken a bone to find out, by taking an online quiz, if they are at risk of osteoporosis and to take action to reduce their risk of further fractures. A low-cost marketing intervention was trialled making printed campaign materials available direct to patients at the point of care (fracture clinic). <h3>Objectives</h3> The analysis sought to establish whether the marketing intervention increased take up of the online quiz, and to what extent taking the quiz influenced people's behaviour with regard to their bone health. <h3>Methods</h3> Between May and October 2017, the NOS placed Stop at One printed campaign materials encouraging people to take the online bone health quiz at 8 sites across the UK covering 13% (16/124) of UK postcode areas. 7 sites had no enhanced provision for secondary fracture prevention such as a fracture liaison service, 1 had a partial service. People who took the online quiz were sent a follow-up survey one month later. <h3>Results</h3> Up to 1st ,<sup>January 2018</sup><sup>1909</sup> people took the quiz: - 89% (1699) of these were over 50 - 95% (1814) were female. - 21% (443) of these lived in postcode areas of the pilot sites. - 1359 people were sent a follow up survey one month after taking the online quiz, and 10% (142) completed it. 27%<sup>39</sup> of these were individuals living in the postcode areas of the pilot sites. When surveyed, of the 142 respondents: - 50% (71) of respondents had broken a bone in the previous ten years. - 73% (104) thought they were at risk of osteoporosis after taking the test. - 24%<sup>34</sup> had either booked or attended an appointment with their GP to discuss their possible risk of osteoporosis. - A further 10%<sup>14</sup> planned to book a GP appointment to discuss their risk. - 31%<sup>43</sup> had made changes to their exercise habits. - 33%<sup>45</sup> had made changes to their diet. <h3>Conclusions</h3> Digital activity (patients accessing website) and the electronic patient survey show meaningful changes in patient behaviour to reduce their fracture risk. Visibility of the awareness campaign at the point of care increased uptake of the quiz and subsequent survey. <h3>Disclosure of Interest</h3> None declared
FRI0517 Vessel wall morphology in giant cell arteritis– a longterm sonographic follow-up study
Authors: E. Schegk, C.T. Berger, S. Imfeld, D. Staub, M. Recher, D. Kyburz, M. Aschwanden, T. Daikeler
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Ultrasound (US) is a cornerstone in the diagnosis of GCA. Only limited data on how US documented large vessel wall thickening changes during treatment is available. <h3>Objectives</h3> To assess arterial vessel wall findings by US during long term follow-up in GCA patients with large vessel vasculitis (LVV) and to correlate findings with the disease course <h3>Methods</h3> Patients with GCA and US defined LV vasculitis were scheduled semiannually for clinical and laboratory assessment as well as US of the temporal (TA), vertebral (VA), carotid (common, internal, external), subclavian (SA), axillary (AXA), deep (DFA), superficial (SFA) and common (CFA) femoral, and popliteal arteries (PA). US findings were classified as normal, moderate or marked vessel wall thickening. <h3>Results</h3> From 42 patients (16 male) with a median age of 75 years at diagnosis 28 had typical vessel wall thickening in the temporal artery and in at least one LV segment and 14 in the LV only. The following vessels (marked/moderate) were most often involved: PA in 11/21, SFA in 13/20, AxA in 14/5, SA in 8/13 patients respectively. A reduction of the vessel wall thickening in the temporal artery during follow-up was found in 79% of patients after in median 7 months, with bilateral normalisation in 10 patients after in median 13 months. In contrast 55% had no, 43% a partial and only one patient a complete reduction of thickening of all LV walls during follow-up. From initially marked supra-aortic LV segments 35% were moderate and 16% normal and from initially moderate LV 13% were normal at 1 year FU. From initially marked infra-aortic LV segments 36% were moderate and 3% normal and from initially moderate 10% were normal at 1 year FU. Progression of vessel wall thickening in the LV during FU was seen in a total of 3 patients, in 2 of those, a clinical relapse of GCA was diagnosed one respectively 2 months before US. There was no difference between patients with reduction of the vessel wall thickening and without during follow-up in respect to clinical parameters (relapse rate over the observation time, cumulative steroid dose after one year). <h3>Conclusions</h3> Regression of US morphological documented thickening of LV in patients with GCA is rare despite clinical remission. US remains sensitive for the diagnosis of LVV long after treatment initiation. Most plasticity is seen in the TA and more rarely in the supra-aortic segments. <h3>Disclosure of Interest</h3> None declared
Kinetics of Myeloid-Derived Suppressor Cells during Stem Cell Mobilization and Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma and Lymphoma Patients
Authors: Anika Betsch, Omer Rutgeerts, Sabine Fevery, Ben Sprangers, Daan Dierickx, Marielle Beckers
Journal: Blood (2018)