tbuckley/cabot-search huggingface dataset:
225Ac Prostate-Specific Membrane Antigen Posttherapy α Imaging
Authors: Sharjeel Usmani, Rashid Rasheed, Fareeda Al kandari, Fahad Marafi, Syed Ali Raza Naqvi
Journal: Clinical Nuclear Medicine (2019)

Ac-based PSMA-targeted therapy has emerged as promising agent for the treatment of metastatic castration-resistant prostate cancer. Posttherapy image is used for tracer localization and dosimetry. Prior 2 photopeaks of 440 and 218 KeV were reported for posttherapy imaging. Our study of gamma ray spectrum, phantom, and clinical images show that imaging with 3 major photopeaks of 78, 218, and 440 KeV gives better quality images, high count statistics, and higher number of lesion delineations. It is therefore suggested that posttherapy imaging may be carried out using 3 major abundant photopeaks.
Reflectance confocal microscopy made easy: The 4 must-know key features for the diagnosis of melanoma and nonmelanoma skin cancers
Authors: Giovanni Pellacani, Alon Scope, Salvador Gonzalez, Pascale Guitera, Francesca Farnetani, Josep Malvehy, Alexander Witkowski, Nathalie De Carvalho, Omar Lupi, Caterina Longo
Journal: Journal of the American Academy of Dermatology (2019)
Junior doctor was negligent in not admitting patient who later died, judge rules
Authors: Clare Dyer
Journal: BMJ (2019)

A junior doctor was negligent in not admitting a 77 year old woman to hospital even though he spoke to the consultant on duty who agreed that the patient could go home, a judge at the High Court in Scotland has ruled.1

Lord Pentland said that he was “left in no doubt” that the junior doctor, Mohamed Izzath, should have suspected that Jean Graham had a serious intra-abdominal abnormality when he saw her at Glasgow Royal Infirmary’s acute assessment unit on 6 January 2013.

An on-call GP had sent Graham to the unit by ambulance with a referral note mentioning suspected melaena secondary to aspirin. Melaena refers to the passage of black tarry stools, resulting from upper gastrointestinal bleeding. Graham had told an NHS 24 call handler and the on-call GP that her stools and vomit were black.

She had originally gone to the emergency …
Asthma paradoxes: time for a new approach across the spectrum of asthma severity
Authors: Richard Beasley, Grace Bird, James Harper, Mark Weatherall
Journal: European Respiratory Journal (2019)

<b>We support the proposal that anti-inflammatory reliever therapy replaces the current use of short-acting β<sub>2</sub>-agonist reliever therapy in adults across the range of asthma severity</b>http://ow.ly/uUtP30nHqhj
THC 联合 CBD 治疗 EB 疼痛
Authors: N.H.B. Schräder, J.C. Duipmans, B. Molenbuur, A. Wolff, M.F. Jonkman
Journal: British Journal of Dermatology (2019)

EB 是一种水疱性疾病,在此病中,甚至轻微的磕碰和摩擦就可导致皮肤出现水疱或溃疡。根据身体上水疱的严重程度和部位,有三种主要类型:单纯性 EB、交界性 EB 和营养不良性 EB。在所有 EB 亚型中,疼痛是极为使人衰弱的症状。每天使用阿片类药物(一类包括例如吗啡等强效镇痛剂的药物)目前是缓解 EB 疼痛的主流药物。阿片类药物通常难以有效管理此疼痛,且与产生耐药性(意味着反复使用时,将需要更高的剂量达到最初的获益)和成瘾相关。在这项来自荷兰的研究中,3 名经受慢性严重疼痛的成人 EB 患者接受药用级大麻素药物 (CBM) 油治疗。所有 3 名参与者都报告称,与他们之前的药物方案相比,在接受 CBM 油治疗期间,所经受的疼痛水平显著下降。另一个获益是瘙痒减轻。大麻素是大麻植物中自然产生的化学物质。大麻包含超过 100 种大麻素,含量最丰富的两种是四氢大麻酚 (THC) 和大麻二醇 (CBD)。不同于 THC,CBD 没有精神活性,意味着它不会像大麻消遣性使用时那样影响情绪、感知和行为。在此研究中使用的 CBM 是 CBD 和 THC 的油基混合物,看起来似乎避免了诸如镇静和中毒等不希望的副作用。通过舌下给予该治疗。这项研究中报告的病例显示,如果这些初始结果在更深入的对照科学研究中得到证实,CBM 油可能会在 EB 治疗中发挥作用。
Stress, itch, and scratch
Authors: H. Mochizuki, M.J. Lavery, L.A. Nattkemper, C. Albornoz, R. Valdes Rodriguez, C. Stull, L. Weaver, J. Hamsher, K.M. Sanders, Y.H. Chan, G. Yosipovitch
Journal: British Journal of Dermatology (2019)

Patients with atopic dermatitis (eczema) often report that stress is a major factor to worsen their itchy skin. This study investigated the effects of acute stress on itch, urge to scratch, and scratching behavior in subjects with atopic dermatitis compared to healthy controls. Stress was created in a standardized way using the Trier Social Stress Test (TSST), where subjects were asked to perform a public speaking task and mental arithmetic. In a second control visit, instead of being stressed, subjects watched a non‐stressful video of landscape scenes. Both subjects with atopic dermatitis and healthy subjects reported feeling stressed after the TSST. Interestingly, atopic dermatitis subjects who were more sensitive to stress also had higher eczema severity. Before and after the TSST or landscape video, cowhage (a plant that causes itch) was applied to the arm of each subject. Patients with atopic dermatitis reported less itch from cowhage and less urge to scratch after they had been stressed by the TSST. However, despite reporting less itch, they actually scratched their limbs significantly more when they were stressed. Healthy individuals did not have any difference in itch, urge to scratch, or scratching behavior in the stressful condition compared to the control landscape video condition. This study shows that acute stress can affect itch and scratching differently in chronic itch patients compared to healthy individuals. Stress led to more scratching in those with atopic dermatitis. Over time, this response to stress could lead to increased skin damage from scratching and therefore worse eczema and itch.
Genomic Drivers of Poor Prognosis and Enzalutamide Resistance in Metastatic Castration-resistant Prostate Cancer
Authors: William S. Chen, Rahul Aggarwal, Li Zhang, Shuang G. Zhao, George V. Thomas, Tomasz M. Beer, David A. Quigley, Adam Foye, Denise Playdle, Jiaoti Huang, Paul Lloyd, Eric Lu, Duanchen Sun, Xiangnan Guan, Matthew Rettig, Martin Gleave, Christopher P. Evans, Jack Youngren, Lawrence True, Primo Lara, Vishal Kothari, Zheng Xia, Kim N. Chi, Robert E. Reiter, Christopher A. Maher, Felix Y. Feng, Eric J. Small, Joshi J. Alumkal
Journal: European Urology (2019)
Abstract 13949: Transendocardial Stem Cell Injection Site Tissue Viability Predicts Ejection Fraction Improvement in Non Ischemic Dilated Cardiomyopathy: An Analysis of POSEIDON-DCM Trial
Authors: Victoria Florea, Makoto Natsumeda, Angela C Rieger, Bryon A Tompkins, Monisha N Banerjee, Aisha Khan, Darcy Difede, Joshua Hare, Raul Mitrani
Journal: Circulation (2017)

Introduction: Transendocardial Stem Cell Injection (TESI) is safe and effective for patients with ischemic and non-ischemic dilated cardiomyopathy (NIDCM). However, the optimal areas for TESI in NI...
Erratum for the Research Article: “Triple-negative breast cancers with amplification of JAK2 at the 9p24 locus demonstrate JAK2-specific dependence” by J. M. Balko, L. J. Schwarz, N. Luo, M. V. Estrada, J. M. Giltnane, D. Dávila-González, K. Wang, V. Sánchez, P. T. Dean, S. E. Combs, D. Hicks, J. A. Pinto, M. D. Landis, F. D. Doimi, R. Yelensky, V. A. Miller, P. J. Stephens, D. L. Rimm, H. Gómez, J. C. Chang, M. E. Sanders, R. S. Cook, C. L. Arteaga
Journal: Science Translational Medicine (2019)
68Ga-DOTA-TATE in Neuroblastoma With Marrow Involvement
Authors: Nese Torun
Journal: Clinical Nuclear Medicine (2019)

A 22-month-old boy diagnosed with neuroblastoma was evaluated by bone scintigraphy and I-metaiodobenzylguanidine scintigraphy, and no metastases to skeletal system was detected. However, plain radiograph and MRI revealed suspected metastatic lesions. The patient was therefore evaluated by Ga-DOTA-TATE PET/CT, and Ga-DOTA-TATE uptake was observed in multiple bone and bone marrow areas, which were consistent with metastases. Biopsy was taken from the right iliac bone, and the pathological examination of the biopsy specimen was coherent with neuroblastoma invasion.
Infographic. Energy availability: concept, control and consequences in relative energy deficiency in sport (RED-S)
Authors: Nicola Keay, Gavin Francis
Journal: British Journal of Sports Medicine (2019)

Relative energy deficiency in sport (RED-S) is an issue of increasing concern in sports and exercise medicine. RED-S impacts exercisers of all levels and ages, particularly where low body weight confers a performance or aesthetic advantage. Key to mitigating adverse health and performance consequences of RED-S is supporting athletes and dancers to change behaviours. These infographics aim to assist clinicians in communicating the concepts to exercisers and in implementing effective management of athletes in their care.1

Figure 1 illustrates the concept of energy availability (EA) in RED-S. Preferentially energy derived …
Tumor endothelial cell-derived cadherin-2 promotes angiogenesis and has prognostic significance for lung adenocarcinoma
Authors: Huiqin Zhuo, Yan Zhao, Xiao Cheng, Mao Xu, Lin Wang, Lingyun Lin, Zhi Lyu, Xuehui Hong, Jianchun Cai
Journal: Molecular Cancer (2019)

In lung cancer, antiangiogenic strategies targeting tumor-derived endothelial cells (TECs) afford a survival advantage, but the characteristics of TECs have not been comprehensively elucidated. Herein, high-purity (> 98%) TECs were obtained, and these cells retained expression of EC markers and exhibited high viability. ITRAQ-2DLC-MS/MS was performed to profile the proteome and the heterogeneity of ECs. Only 31 of 1820 identified proteins were differentially expressed between adenocarcinoma (ADC)- and squamous cell carcinoma (SCC)-derived TECs (TEC-A and TEC-S, respectively), and cadherin-2 (CDH2) was the most significantly upregulated protein in TEC-A samples. Positive immunostaining for CDH2 (score > 3) was significantly more frequent in the endothelium of ADC tissues than in that of SCC tissues. Loss- or gain-of-function analysis showed that CDH2 significantly promoted in vitro and in vivo angiogenesis and sensitivity to the antagonist exherin. The MAPK/ERK and MAPK/JNK signaling pathways may play crucial roles in CDH2-induced HIF-1α/VEGF-mediated angiogenesis. Moreover, high CDH2 expression in TECs was significantly associated with tumor stage, visceral pleural metastasis, and decreased overall survival in patients with ADC but not SCC. Together, these data indicate the importance of CDH2 in angiogenesis and highlight its potential both for antiangiogenic therapy and as a candidate prognostic marker for ADC.
Mandibular Advancement Devices
Authors: Francois-Xavier Petit, Jean-Louis Pépin, Georges Bettega, Hazem Sadek, Bernard Raphaël, Patrick Lévy
Journal: American Journal of Respiratory and Critical Care Medicine (2002)

Mandibular advancement devices (MAD) should be contraindicated (Clark GT, Sleep Med Rev 1998;2:163–174) if there are: (1) insufficient teeth to support the device, (2) periodontal problems inducing tooth mobility, (3) active temporomandibular joint (TMJ) disorder, and (4) limited maximum protrusive distance (< 6 mm). The aim of the present study was to evaluate the proportion of the obstructive sleep apnea population that exhibits any contraindication (CI) to MAD. For this study there were 100 unselected adult patients consecutively diagnosed by polysomnography in a tertiary sleep laboratory. Clinical and radiologic evaluation of the dental, periodontal, and TMJ status of these 100 patients were performed by two expert maxillofacial surgeons, blind to each other, permitting the identification of MAD CIs. The two maxillofacial surgeons agreed on MAD absolute CIs in 96 of the 100 patients. CIs were identified in 34% of the patients. The nature of the CIs systematically referred to an insufficient number of remaining teeth (mean number of teeth lost: 7.8 ± 6.1 with 31 patients having had more than 10 teeth removed). The tooth avulsions were significantly higher in contraindicated compared with noncontraindicated patients (16 ± 8 versus 4 ± 3, p < 0.00001). Periodontal abnormalities coexisted with dental CI in approximately half of the patients. A TMJ disorder was considered as significant enough to lead to CI in two patients. Dental and periodontal care was needed in 16 patients before the use of MAD could be considered. Conclusions were that primary CIs were present in 34% of 100 consecutive patients, mainly owing to dental problems. Moreover, another subgroup of patients (16%) required close supervision and follow-up to avoid impairment of preexisting TMJ and dental problems. Such a high rate of CI should be considered when the overall efficacy of oral appliances is compared with other treatments, such as surgery or nasal continuous positive airway pressure.
Results from the randomized controlled IHOPE trial suggest no effects of oral protein supplementation and exercise training on physical function in hemodialysis patients
Authors: Jin Hee Jeong, Annabel Biruete, Emily J. Tomayko, Pei Tzu Wu, Peter Fitschen, Hae Ryong Chung, Mohamad Ali, Edward McAuley, Bo Fernhall, Shane A. Phillips, Kenneth R. Wilund
Journal: Kidney International (2019)
Reply to E. Hindié and K.R. Hess
Authors: Georgina V. Long, Reinhard Dummer, Dirk Schadendorf, Mario Santinami, Victoria Atkinson, Mario Mandalà, Vanna Chiarion-Sileni, James Larkin, Marta Nyakas, Caroline Dutriaux, Andrew Haydon, Caroline Robert, Laurent Mortier, Jacob Schachter, Thierry Lesimple, Ruth Plummer, Kohinoor Dasgupta, Tomas Haas, Mark Shilkrut, Eduard Gasal, Richard Kefford, John M. Kirkwood, Axel Hauschild
Journal: Journal of Clinical Oncology (2019)
Abstract 21160: Predictors of Early Readmission and Complications Associated With Atrial Flutter Ablation
Authors: Byomesh K Tripathi, Shilpkumar Arora, Nilay Patel, Abhishek Mishra, Sopan Lahewala, Neil Patel, Varun Kumar, Mihir Dave, Madan Badal, Nirali Patel, Prashant Patel, Mustafa Kagalwala, Nilesh Patel, Radha Gopalan
Journal: Circulation (2017)

Introduction: Atrial flutter (AFL) ablation is associated with significant complications. Recognition of predictors of worse outcomes early is critical. Methods: National Readmission Data (NRD) 2013-14 was utilized to select study cohort and AFL and Cather ablation were identified using International Classification of Diseases, 9th Revision (ICD-9-CM) diagnostic code 427.32 and procedure code 37.34 respectively. Admissions within 90 day of index admission were considered as early readmissions. Cox proportional hazard regression and hierarchical two level logistic models were used to evaluate predictors of early readmission and complications. Result: A total of 1010 patients were readmitted (18.36%). Significant predictors of early readmission included [Hazards Ratio (HR), 95% confidence interval (CI), p-value] heart failure (HR: 1.30, 95% CI: 1.13 - 1.49, p &lt; 0.001), chronic pulmonary disease (HR: 1.37, 95% CI: 1.18 - 1.58, p &lt; 0.001), anemia (HR: 1.23, 95% CI: 1.02 - 1.49, p = 0.035), malignancy (HR: 1.87, 95% CI: 1.40 - 2.49, p&lt;0.001), weekend admission(HR: 1.23, 95% CI: 1.02 - 1.47, p = 0.029) compared to weekday admission, index hospitalization length of stay of 3 to 4 days(HR: 1.29, 95% CI: 1.09 - 1.52, p = 0.003) and ≥ 5days (HR: 1.39, 95% CI: 1.16 - 1.65, p &lt; 0.001) compared to length of stay of ≤2 days. (Figure 1A) Overall complication rate of 4% was noted. Cardiac complications were most common. Predictors of complications (odds ratio=OR, 95% confidence interval= CI, p-value) were diabetes (OR:1.50, CI-1.18-1,92, p&lt;0.001), heart failure (OR:1.44, CI:1.12-1.85, p=0.005), peripheral vascular disease (OR:2.62, CI-1.87-3.69, p&lt;0.001) and anemia (OR:2.02, CI-1.45-2.80, p&lt;0.001). (Figure 1B) Conclusion: Identification of high risk population based on certain pre-existing conditions can have improved outcomes in patients undergoing AFL ablation.
From the American College of Chest Physicians: Guidelines on Conflict-of-Interest Management—Reply
Authors: Rishad Khan, Michael A. Scaffidi, Samir C. Grover
Journal: JAMA Internal Medicine (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Bone mineral density in cystic fibrosis patients using low-dose chest computed tomography: a pilot study
Authors: Rubens Gabriel Feijó Andrade, Gabriele Carra Forte, Bruno Hochhegger, Leonardo Araujo Pinto
Journal: European Respiratory Journal (2019)

<b>Bone mineral density assessed using a low-dose chest computed tomography in cystic fibrosis presented a strong correlation with DXA. For CF patients, there is an additional possible benefit of assessing lung and bone health using only one method.</b>http://bit.ly/2vsCYrQ
Pooled Safety Analysis from Phase I and II Studies for Patients with Relapsed Indolent Non-Hodgkin's Lymphoma Treated with Intravenous Copanlisib
Authors: Pier Luigi Zinzani, Amita Patnaik, Franck Morschhauser, Gilles Andre Salles, Armando Santoro, Luigina Mollica, Krimo Bouabdallah, David Cunningham, Sirpa Leppa, George Follows, Alice Benson, Peter Bonata, Isabelle Genvresse, Ashok Miriyala, Aruna Mehra, Jose Garcia-Vargas, Barrett H. Childs, Martin Dreyling
Journal: Blood (2017)
Distinct Profiles on Subjective and Objective Adherence Measures in Patients Prescribed Antidepressants
Authors: Hans Wouters, Didi Rhebergen, Marcia Vervloet, Antoine Egberts, Katja Taxis, Liset van Dijk, Helga Gardarsdottir
Journal: Drugs (2019)

A recurrent observation is that associations between self-reported and objective medication adherence measures are often weak to moderate. Our aim was therefore to identify patients with different profiles on self-reported and objective adherence measures. This was an observational study of 221 community pharmacy patients who were dispensed antidepressants. Adherence profiles were estimated with Latent Profile Analysis (LPA) using data on self-reported adherence (Medication Adherence Rating Scale) complemented with data on medication beliefs (perceived necessity and concerns measured with the Beliefs about Medicines Questionnaire) and data from objective adherence measures (electronic monitoring of medication taking and the Medication Possession Ratio calculated from pharmacy dispensing data). 'Goodness-of-fit' statistics indicated the presence of three classes: "concordantly high adherent" (83%, high adherence on all measures), "concordantly suboptimal adherent" (11%, low adherence on all measures), and "discordant" (6%, high self-reported adherence but lower adherence on objective measures). Most patients had concordant outcomes on self-reported and objective measures of adherence. A small discordant class had high self-reported but low objective adherence. LPA will enable sensitivity analyses in future studies, for example excluding patients from the discordant class.
Breast cancer cells co-cultured with neutrophils express endogenous oncostatin M (OSM)
Authors: Marisa Queen, Alexander Ide, Kencee Amyx, Barbara Smith, Randall E. Ryan, Cheryl L. Jorcyk
Journal: Cancer Research (2004)

660  Oncostatin M (OSM) is a pleiotropic cytokine belonging to the interleukin-6 family and is expressed by several cell types, including activated human T-lymphocytes and macrophages. Recent evidence suggests that OSM may promote tumor progression by enhancing angiogenesis and metastasis. Tumor-associated and tumor-infiltrating neutrophils (TANs) and macrophages (TAMs) can account for as much as 50% of the total tumor mass in invasive breast carcinomas. It is thought that tumors secrete factors that elicit a wound-repair response from TAMs and TANs, and that this response inadvertently stimulates tumor progression. Our preliminary findings have shown that human neutrophils express OSM when co-cultured with human MDA-MB-231 breast cancer cells. Neutrophils were isolated from whole blood and then plated with breast cancer cells at different ratios. Neutrophils and breast cancer cells alone did not express OSM by immunohistochemistry, but when co-cultured together at a ratio of 10:1 for 3 to 5 days, neutrophils expressed OSM. In fibroblasts, OSM has also been shown to induce the expression of proteases, whose activities are reported to correlate with metastatic potential in tumor models. Matrix metalloproteinase (MMPs) and other proteolytic enzymes have been demonstrated to play critical roles in the angiogenesis cascade and to be markers of metastatic potential. Presently, we are examining whether neutrophil-derived OSM will induce proteases, such as MMPs, in co-cultured breast cancer cells utilizing ELISAs and immunoblotting. Positive findings could provide a rationale for the development of therapies that inhibit OSM. The potential to develop anti-OSM therapeutics is currently limitless: to date, there has been no attempt to inhibit OSM for the purposes of cancer therapy.
Paediatrician who downloaded videos of child abuse is given suspended sentence
Authors: Clare Dyer
Journal: BMJ (2019)

A former junior doctor in paediatrics has been spared jail after police found dozens of images of serious child sexual abuse on his laptop during a raid on his home.

Ralph Harper, 31, was given an eight month suspended sentence at Snaresbrook Crown Court, Greater London, after downloading images that included serious assaults on children as young as 8.

Harper was a …
Car Accident With Airbag Deployment Trauma Showed Special Pattern in Bone Scan
Authors: Tzyy-Ling Chuang, Ta-Wen Hsu, Shih-Chin Chou, Yuh-Feng Wang
Journal: Clinical Nuclear Medicine (2019)

A 72-year-old man had rectal adenocarcinoma with partial obstruction with liver and lung metastases. Bone scan showed special pattern with bony destructions to the lateral aspect of the left first to fourth and right first to 10th ribs (in a row in continuous vertical alignment), the costal end of the left second rib, the left sternoclavicular junction, and sternum. Patient recalled a car traffic accident with airbag deployment trauma to the anterior aspect of the chest about 2 months prior. Chest CT confirmed that the bone lesions were all fractures.
Physicians' guideline adherence is associated with long‐term heart failure mortality in outpatients with heart failure with reduced ejection fraction: the QUALIFY international registry
Authors: Michel Komajda, Jakob Schöpe, Stefan Wagenpfeil, Luigi Tavazzi, Michael Böhm, Piotr Ponikowski, Stefan D. Anker, Gerasimos S. Filippatos, Martin R. Cowie
Journal: European Journal of Heart Failure (2019)