tbuckley/cabot-search huggingface dataset:
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Authors: Wei‐Yu Kao, Elise Chia‐Hui Tan, Chien‐Wei Su
Journal: Hepatology (2019)

Potential conflict of interest: Dr. Kao is on the speakers’ bureau for Gilead, Bristol‐Myers Squibb, AbbVie, Bayer, and Roche. Dr. Su advises for and is on the speakers’ bureau for Gilead. He is on the speakers’ bureau for Bristol‐Myers Squibb, AbbVie, Bayer, and Roche. We appreciate the comments by Lai on our study.1 We completely agree that proton pump inhibitor (PPI) use is not associated with an increased risk of hepatocellular carcinoma (HCC) development in patients with chronic hepatitis B or C. However, another recent nested case‐control study, using the Taiwan National Health Insurance (NHI) database, showed that PPI use might increase the risk of HCC in patients without hepatitis B or C infection.2 The different results between Shao et al. and our study may be attributed to the different study designs (case‐control study vs. cohort study) and subjects (nonviral hepatitis vs. viral hepatitis). Because the majority (>80%) of HCC patients in Taiwan and East Asia have an active ongoing or resolved viral hepatitis, our study might provide more clinical implications for patients who bear a higher risk of developing HCC.3 Regarding the nonviral etiology of HCC, Lai conducted a cohort study using the Taiwan NHI database, and it showed that incidences of HCC were similar between PPI users and non‐PPI users after excluding alcohol‐related disease, cirrhosis, hepatitis B infection, hepatitis C infection, other chronic hepatitis, and diabetes mellitus.4 Furthermore, another recent meta‐analysis of five observational studies demonstrated that PPI use was not associated with an increased risk of HCC.5 The results were consistent after excluding two studies that enrolled patients with chronic hepatitis B or C. Taken together, most published human studies of PPI use and HCC risk have revealed weak associations and are prone to residual confounding or protopathic bias, both in terms of viral etiology and nonviral etiology of HCC.2 Based on these studies, PPI use is not associated with an increased risk of developing HCC both in patients with and those without viral hepatitis. The overinterpretation and sensationalization of medical studies has led to public misinformation and should not be overextrapolated to alter clinical practice. Therefore, more prospective, large‐scale, randomized controlled clinical trials with long‐term follow‐up studies are warranted to establish the relationship between PPI use and HCC.
Abstract 18356: Deficient Problem-Solving Abilities Are Associated With Unhealthy Behaviors and Factors Among Patients With Comorbid Obesity and Depression
Authors: Lisa Goldman Rosas, Nan Lv, Lan Xiao, Mark Snowden, Lesley Steinman, Elizabeth Venditti, Megan Lewis, Jeremy Goldhaber-Fiebert, Jun Ma
Journal: Circulation (2017)

Introduction: Deficient problem-solving abilities are linked to chronic health problems such as obesity and depression, although underlying mechanisms are unclear. Examining the association of prob...
Endocrine and Metabolic Diseases Among Colorectal Cancer Survivors in a Population-Based Cohort
Authors: Makenzie L Hawkins, Brenna E Blackburn, Kerry Rowe, John Snyder, Vikrant G Deshmukh, Michael Newman, Alison Fraser, Ken Smith, Kimberly Herget, Patricia A Ganz, N Jewel Samadder, Mia Hashibe
Journal: JNCI Journal of the National Cancer Institute (2019)

There are an estimated 1.4 million colorectal cancer (CRC) survivors in the United States. Research on endocrine and metabolic diseases over the long term in CRC survivors is limited. Obesity is a risk factor for CRC; thus it is of interest to investigate diseases that may share this risk factor, such as diabetes, for long-term health outcomes among CRC survivors.
Mechanical Characterization of Human Brain Tissue and Soft Dynamic Gels Exhibiting Electromechanical Neuro‐Mimicry
Authors: Anthony Tabet, Stefan Mommer, Julian A. Vigil, Clement Hallou, Harry Bulstrode, Oren A. Scherman
Journal: Advanced Healthcare Materials (2019)

Abstract Synthetic hydrogels are an important class of materials in tissue engineering, drug delivery, and other biomedical fields. Their mechanical and electrical properties can be tuned to match those of biological tissues. In this work, hydrogels that exhibit both mechanical and electrical biomimicry are reported. The presented dual networks consist of supramolecular networks formed from 2:1 homoternary complexes of imidazolium‐based guest molecules in cucubit[8]uril and covalent networks of oligoethylene glycol‐(di)methacrylate. The viscoelastic properties of human brain tissues are also investigated. The mechanical properties of the dual network gels are benchmarked against the human tissue, and it is found that they both are neuro‐mimetic and exhibit cytocompatibility in a neural stem cell model.
Analysis of Genomic Predispositions to Sporadic Myeloid Neoplasms Mediated By DDX41 in Japan
Authors: June Takeda, Kenichi Yoshida, Tetsuichi Yoshizato, Yuichi Shiraishi, Yusuke Okuno, Ayana Kon, Keisuke Kataoka, Kenichi Chiba, Hiroko Tanaka, Masashi Sanada, Ken Ishiyama, Shigeru Chiba, Norio Asou, Yasushi Miyazaki, Tomoki Naoe, Kensuke Usuki, Shuichi Miyawaki, Yoichiro Kamatani, Yukihide Momozawa, Masao Nagasaki, Satoru Miyano, Michiaki Kubo, Hideki Makishima, Seishi Ogawa
Journal: Blood (2018)
Notice of Retraction. Maret-Ouda et al. Risk of Esophageal Adenocarcinoma After Antireflux Surgery in Patients With Gastroesophageal Reflux Disease in the Nordic Countries. <i>JAMA Oncol</i>. 2018;4(11):1576-1582
Authors: Jesper Lagergren
Journal: JAMA Oncology (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Singling out Th2 cells in eosinophilic esophagitis
Authors: Walter L. Eckalbar, David J. Erle
Journal: Journal of Clinical Investigation (2019)

Eosinophilic esophagitis (EoE) is a recently described disease in which exposure to specific foods and allergens leads to type 2 inflammation, epithelial barrier dysfunction, and difficulty in swallowing. In the current issue of the JCI, Wen and colleagues investigate tissue T cell heterogeneity in patients with EoE using single-cell RNA sequencing (scRNA-seq). Esophageal epithelium from individuals with EoE convtained a prominent population of Th2 cells not seen in controls. The short-chain fatty acid (SCFA) receptor FFAR3 was found to be highly expressed in EoE Th2 cells. Experiments presented here provide evidence that SCFAs may promote type 2 inflammation in allergic diseases such as EoE and asthma. This study provides an early example of scRNA-seq for identifying relevant cell populations and mechanisms underlying allergic diseases.
Impact of the gut microbiome on the genome and epigenome of colon epithelial cells: contributions to colorectal cancer development
Authors: Jawara Allen, Cynthia L. Sears
Journal: Genome Medicine (2019)

In recent years, the number of studies investigating the impact of the gut microbiome in colorectal cancer (CRC) has risen sharply. As a result, we now know that various microbes (and microbial communities) are found more frequently in the stool and mucosa of individuals with CRC than healthy controls, including in the primary tumors themselves, and even in distant metastases. We also know that these microbes induce tumors in various mouse models, but we know little about how they impact colon epithelial cells (CECs) directly, or about how these interactions might lead to modifications at the genetic and epigenetic levels that trigger and propagate tumor growth. Rates of CRC are increasing in younger individuals, and CRC remains the second most frequent cause of cancer-related deaths globally. Hence, a more in-depth understanding of the role that gut microbes play in CRC is needed. Here, we review recent advances in understanding the impact of gut microbes on the genome and epigenome of CECs, as it relates to CRC. Overall, numerous studies in the past few years have definitively shown that gut microbes exert distinct impacts on DNA damage, DNA methylation, chromatin structure and non-coding RNA expression in CECs. Some of the genes and pathways that are altered by gut microbes relate to CRC development, particularly those involved in cell proliferation and WNT signaling. We need to implement more standardized analysis strategies, collate data from multiple studies, and utilize CRC mouse models to better assess these effects, understand their functional relevance, and leverage this information to improve patient care.
Heart and Lung Transplants from HCV-Infected Donors to Uninfected Recipients
Authors: Ann E. Woolley, Steve K. Singh, Hilary J. Goldberg, Hari R. Mallidi, Michael M. Givertz, Mandeep R. Mehra, Antonio Coppolino, Amanda E. Kusztos, Megan E. Johnson, Kaiwen Chen, Esther A. Haddad, John Fanikos, David P. Harrington, Phillip C. Camp, Lindsey R. Baden
Journal: New England Journal of Medicine (2019)

Hearts and lungs from donors with hepatitis C viremia are typically not transplanted. The advent of direct-acting antiviral agents to treat hepatitis C virus (HCV) infection has raised the possibility of substantially increasing the donor organ pool by enabling the transplantation of hearts and lungs from HCV-infected donors into recipients who do not have HCV infection.
Multiscale analyses reveal native-like lamellar bone repair and near perfect bone-contact with porous strontium-loaded bioactive glass
Authors: H. Autefage, F. Allen, H.M. Tang, C. Kallepitis, E. Gentleman, N. Reznikov, K. Nitiputri, A. Nommeots-Nomm, M.D. O'Donnell, C. Lange, B.M. Seidt, T.B. Kim, A.K. Solanki, F. Tallia, G. Young, P.D. Lee, B.F. Pierce, W. Wagermaier, P. Fratzl, A. Goodship, J.R. Jones, G. Blunn, M.M. Stevens
Journal: Biomaterials (2019)

The efficient healing of critical-sized bone defects using synthetic biomaterial-based strategies is promising but remains challenging as it requires the development of biomaterials that combine a 3D porous architecture and a robust biological activity. Bioactive glasses (BGs) are attractive candidates as they stimulate a biological response that favors osteogenesis and vascularization, but amorphous 3D porous BGs are difficult to produce because conventional compositions crystallize during processing. Here, we rationally designed a porous, strontium-releasing, bioactive glass-based scaffold (pSrBG) whose composition was tailored to deliver strontium and whose properties were optimized to retain an amorphous phase, induce tissue infiltration and encourage bone formation. The hypothesis was that it would allow the repair of a critical-sized defect in an ovine model with newly-formed bone exhibiting physiological matrix composition and structural architecture. Histological and histomorphometric analyses combined with indentation testing showed pSrBG encouraged near perfect bone-to-material contact and the formation of well-organized lamellar bone. Analysis of bone quality by a combination of Raman spectral imaging, small-angle X-ray scattering, X-ray fluorescence and focused ion beam-scanning electron microscopy demonstrated that the repaired tissue was akin to that of normal, healthy bone, and incorporated small amounts of strontium in the newly formed bone mineral. These data show the potential of pSrBG to induce an efficient repair of critical-sized bone defects and establish the importance of thorough multi-scale characterization in assessing biomaterial outcomes in large animal models.
Association of Rhinovirus C Bronchiolitis and Immunoglobulin E Sensitization During Infancy With Development of Recurrent Wheeze
Authors: Kohei Hasegawa, Jonathan M. Mansbach, Yury A. Bochkov, James E. Gern, Pedro A. Piedra, Cindy S. Bauer, Stephen J. Teach, Susan Wu, Ashley F. Sullivan, Carlos A. Camargo
Journal: JAMA Pediatrics (2019)

Rhinovirus infection in early life, particularly with allergic sensitization, is associated with higher risks of developing recurrent wheeze and asthma. While emerging evidence links different rhinovirus species (eg, rhinovirus C) to a higher severity of infection and asthma exacerbation, to our knowledge, little is known about longitudinal associations of rhinovirus C infection during infancy with subsequent morbidities.To examine the association of different viruses (respiratory syncytial virus [RSV], rhinovirus species) in bronchiolitis with risks of developing recurrent wheeze.This multicenter prospective cohort study of infants younger than 1 year who were hospitalized for bronchiolitis was conducted at 17 hospitals across 14 US states during 3 consecutive fall to winter seasons (2011-2014).Major causative viruses of bronchiolitis, including RSV (reference group) and 3 rhinovirus species (rhinovirus A, B, and C).Development of recurrent wheeze (as defined in national asthma guidelines) by age 3 years.This analytic cohort comprised 716 infants who were hospitalized for RSV-only or rhinovirus bronchiolitis. The median age was 2.9 months (interquartile range, 1.6-3.8 months), 541 (76%) had bronchiolitis with RSV only, 85 (12%) had rhinovirus A, 12 (2%) had rhinovirus B, and 78 (11%) had rhinovirus C infection. Overall, 231 (32%) developed recurrent wheeze by age 3 years. In the multivariable Cox model, compared with infants with RSV-only infection, the risk of recurrent wheeze was not significantly different in those with rhinovirus A or B (rhinovirus A: hazard ratio [HR], 1.27; 95% CI, 0.86-1.88; rhinovirus B: HR, 1.39; 95% CI, 0.51-3.77; both P > .10). By contrast, infants with rhinovirus C had a significantly higher risk (HR, 1.58; 95% CI, 1.08-2.32). There was a significant interaction between virus groups and IgE sensitization on the risk of recurrent wheeze (P for interaction < .01). Only infants with both rhinovirus C infection and IgE sensitization (to food or aeroallergens) during infancy had significantly higher risks of recurrent wheeze (HR, 3.03; 95% CI, 1.20-7.61). Furthermore, compared with RSV-only, rhinovirus C infection with IgE sensitization was associated with significantly higher risks of recurrent wheeze with subsequent development of asthma at age 4 years (HR, 4.06; 95% CI, 1.17-14.1).This multicenter cohort study of infants hospitalized for bronchiolitis demonstrated between-virus differences in the risk of developing recurrent wheeze. Infants with rhinovirus C infection, along with IgE sensitization, had the highest risk. This finding was driven by the association with a subtype of recurrent wheeze: children with subsequent development of asthma.
Corrigendum to: “Lithium-containing biomaterials stimulate bone marrow stromal cell-derived exosomal miR-130a secretion to promote angiogenesis” [Biomaterials 192(2019) 523–536]
Authors: Lu Liu, Yaqin Liu, Chun Feng, Jiang Chang, Runqing Fu, Tingting Wu, Fei Yu, Xiaoting Wang, Lunguo Xia, Chengtie Wu, Bing Fang
Journal: Biomaterials (2019)
Abstract 13074: High Detection Rates of Atrial Fibrillation in Patients After a Cerebrovascular Event by Systematic ECG Monitoring With an Implanted Device: SPIDER-AF Study
Authors: Franz Goss, Karin Rybak, Ralph Bosch, Markus Seige, Winfried Haerer, Bernd Schütz, Rolf Mitusch, Michael Müller, Ullus Heinrich, Reinhard Stöhring, Oliver Turschner, Andreas Knapp, Martin Jauernig, Michael Drexler
Journal: Circulation (2018)

Introduction: Atrial fibrillation (AF) is associated with a substantial increase in the risk of stroke and cardiovascular morbidity. Therefore, early detection of AF to initiate appropriate therapy...
Food processing and occupational respiratory allergy‐ An EAACI position paper
Authors: Mohamed F. Jeebhay, Gianna Moscato, Berit E. Bang, Ilenia Folletti, Agnieszka Lipińska‐Ojrzanowska, Andreas L. Lopata, Gianni Pala, Santiago Quirce, Monika Raulf, Joaquin Sastre, Ines Swoboda, Jolanta Walusiak‐Skorupa, Andrea Siracusa
Journal: Allergy (2019)

Occupational exposure to foods is responsible for up to 25% of cases of occupational asthma and rhinitis. Animal and vegetable high-molecular-weight proteins present in aerosolized foods during food processing, additives, preservatives, antioxidants, and food contaminants are the main inhalant allergen sources. Most agents typically cause IgE-mediated allergic reactions, causing a distinct form of food allergy (Class 3 food allergy). The allergenicity of a food protein, allergen exposure levels, and atopy are important risk factors. Diagnosis relies on a thorough medical and occupational history, functional assessment, assessment of sensitization, including component-resolved diagnostics where appropriate, and in selected cases specific inhalation tests. Exposure assessment, including allergen determination, is a cornerstone for establishing preventive measures. Management includes allergen exposure avoidance or reduction (second best option), pharmacological treatment, assessment of impairment, and worker's compensation. Further studies are needed to identify and characterize major food allergens and define occupational exposure limits, evaluate the relative contribution of respiratory versus cutaneous sensitization to food antigens, evaluate the role of raw versus cooked food in influencing risk, and define the absolute or relative contraindication of patients with ingestion-related food allergy, pollinosis, or oral allergy syndrome continuing to work with exposure to aerosolized food allergens.
Psychiatric Comorbidity in Moyamoya Disease and Preliminary Guidelines For Treatment
Authors: Misty Richards, Adrienne Grzenda, Evelyn Nelson, Michael Gitlin
Journal: American Journal of Psychiatry (2019)

Moyamoya disease is a cerebrovascular disorder of unknown etiology characterized by progressive unilateral or bilateral stenosis of the distal internal carotid arteries, frequently extending to the anterior and middle cerebral arteries.Cerebral angiogram reveals fragile compensatory collateral vessels forming along the base of the brain, resembling a "Ms.A" is a 54-year-old Chinese-American woman with no psychiatric history who presented to the emergency department in a "psychotic break."She could not provide a coherent history and appeared withdrawn, selectively mute, and confused.Her husband reported that her father had died unexpectedly 2 weeks earlier from natural causes.When she returned to work after a few days off, she disappeared for several hours, without recollection of her activities.Ms. A's physical examination was normal, with stable vital signs with mild systolic hypertension (143/86 mmHg).Fully oriented to person, place, time, and situation, she denied acute psychiatric concerns apart from sadness over her father's death.Her medical, social, and family histories were unremarkable.Findings from routine altered mental status screening, including CT, serological studies, and lumbar puncture, were negative.Urinalysis, however, showed pyuria.A diagnosis of cystitis was made, for which cephalexin was prescribed, and Ms.A was discharged home with her husband.She returned to the emergency department 2 days later with worsening symptoms and new incontinence.Psychiatry was consulted and discharged her home to begin sertraline at 50 mg/day for observed depressive symptoms.At outpatient psychiatric follow-up 1 week later, her psychomotor retardation, mutism, and cognitive slowing were unchanged.She disclosed "feelings of inadequacy" and "sad" mood, describing her father's death as "devastating."She frequently repeated the clinician's questions, but her orientation was intact.When asked to write her thoughts, she inscribed, "I am scared and excited," over 100 times on a sheet of paper.She denied domestic violence when interviewed alone.Her sertraline dosage was increased to 100 mg/day, and lorazepam was started at 1 mg b.i.d. to treat presumptive catatonia.
Prediction of Anti-FVIII Inhibitor Persistence By Anti-FVIII IgG Subclasses in Patients with Severe Hemophilia — A in the Sippet Cohort Study
Authors: Flora Peyvandi, Paolo Bucciarelli, Carla Valsecchi, Marco Boscarino, Roberta Palla, Elena Santagostino, Amal El-Beshlawy, Mohsen Saleh Elalfy, Vijay M. Ramanan, Peyman Eshghi, Suresh Hanagavadi, Mehran Karimi, Cecil Ross, Mamta V Manglani, Guy Young, Tulika Seth, Shashikant Apte, Dinesh M Nayak, Maria Elisa Mancuso, Johnny Mahlangu, Bonanad Santiago, Monica H Cerqueira, Nadia P Ewing, Christoph Male, Tarek Owaidah, Veronica Soto Arellano, Suvankar Majumdar, Mindy Simpson, Mathew Thomas, Ezio Zanon, Marilyn J Manco-Johnson, Monica Martinez, Maria Gabriella Mazzucconi, Daniela Neme, Rogelio Alejandro Paredes-Aguilera, Alessandra N L Prezotti, Klaus Schmitt, Bulent Zulfikar, Pier Mannuccio Mannucci, Frits Richard Rosendaal
Journal: Blood (2018)
Michael's Testimonial
Authors: David Killoran
Journal: Annals of Internal Medicine (2019)

Letters2 April 2019Michael's TestimonialDavid Killoran, EsqDavid Killoran, EsqALS Action Foundation, San Francisco, California (D.K.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L19-0045 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read Danielson and Dubé's essay (1) with interest. My wife was diagnosed with ALS in California before the End of Life Option Act was enacted. The day of her diagnosis, she said, “Take me to Oregon.” Physician-assisted suicide was legal there. I told her I would respect any choice she made. Four years later, she had a stroke and became unresponsive for 5 days; 2 neurologists said she had severe and permanent brain damage. In accordance with her written instructions, I dutifully removed her ventilator and stopped all nutrition and medication except morphine for comfort. Two ...Reference1. Danielson MM, Dubé K. Michael's testimonial. Ann Intern Med. 2018;169:349. [PMID: 30178018]. doi:10.7326/M18-1719 LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: ALS Action Foundation, San Francisco, California (D.K.)Disclosures: The author has disclosed no conflicts of interest. The form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L19-0045. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMichael's Testimonial Michael M. Danielson and Karine Dubé Michael's Testimonial Michael M. Danielson and Karine Dubé Michael's Testimonial Roger S. LaBonte Michael's Testimonial Stephen Strum Metrics 2 April 2019Volume 170, Issue 7Page: 510-511KeywordsEnd of life careHealth care providersHealth care sectorMorphineNutritionPatient advocacySleepStrokeSuicideVentilators ePublished: 2 April 2019 Issue Published: 2 April 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Degree and Effect Of Weight Loss In Acute Myeloid Leukemia Patients Receiving Induction and Post-Remission Chemotherapy
Authors: Surbhi Sidana, Sudipto Mukherjee, Paul Elson, David J. Seastone, Aziz Nazha, Amanda L. Maggiotto, Ccrp, Madeline J. Schaub, Candice M. Wenzell, Bcop, Anjali S. Advani, Matt Kalaycio, Mikkael A. Sekeres
Journal: Blood (2013)