tbuckley/cabot-search huggingface dataset:
SAT0678 Seasonality of new early inflammatory arthritis cases: preliminary results from the canadian early arthritis cohort
Authors: F. Kudaeva, M. Speechley, N. Klar, O. Schieir, S. Bartlett, C. Hitchon, G. Boire, B. Haraoui, E. Keystone, D. Tin, C. Thorne, V. Bykerk, J. Pope
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Disease clustering suggests a possible environmental cause. However, confirming the causes of time-place clustering is challenging. Rheumatoid arthritis (RA) is an autoimmune disease that may be triggered by environmental factors: viral or bacterial infections can lead to RA via molecular mimicry, epitope spreading, B-cell-mediated pathway, bystander activation and via superantigens. Putative infections may also cluster. <h3>Objectives</h3> To study the seasonal distribution of early inflammatory arthritis (IA) onsets in a Canadian sample, and potential relationships with influenza (flu) outbreaks. <h3>Methods</h3> Data from an incidence cohort of adults (&gt;18 years) with early IA with &lt;13 months symptom duration from the Canadian Early Arthritis Cohort (CATCH) enrolled between January 2007 – January 2017. Patient-reported date of symptom onset and physician-reported date of IA onset were used to estimate the monthly frequency of early inflammatory arthritis onsets. Monthly flu case frequencies from September 2010 – December 2016 were retrieved from the Public Health Agency of Canada's FluWatch national surveillance system of confirmed influenza A and B cases. Time-series Poisson regression analyses were performed to assess the non-random covariance of IA and flu with different hypothesised time lags. <h3>Results</h3> A total of 2262 with early IA were included. Patient-reported IA onset was more frequent in winter months compared to other seasons (p=0.002), with peaks in January (figure 1). The ten-year aggregated data also showed January peaks of IA onset. There was a positive linear correlation between the number of IA and influenza A onsets (r=0.23, p=0.045), and almost no relationship between the number of IA and influenza B cases (p=0.87) (figure 2). <h3>Conclusions</h3> Our study provides novel information on the increased onset of IA in relation to seasonal influenza patterns in a Canadian population and adds to the existing literature supporting viral infections as a possible trigger to RA onset. <h3>Disclosure of Interest</h3> None declared
THU0747-HPR The effect of clinical pilates exercises on disease specific-indices, core stabilisation and balance in patients with ankylosing spondylitis
Authors: Y. Acar, B. Gürpınar, G. Can, F. Önen, N. Özdemir
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> The Pilates method has been widely used to improve physical fitness and rehabilitation in general. Altough Pilates method gives precedence to the spine and focuses on controlled movement, posture, and breathing, which are obviously the basic goals of Ankilozing Spondylitis(AS) treatment there is limited literature on the effectiveness of the Pilates method as treatment for patients with AS. <h3>Objectives</h3> The aim of this study was to investigate the efficacy of clinical pilates exercises on on disease-specific indices, core stabilisation and balance in patients with AS. <h3>Methods</h3> The study included 21 AS patients(11 male, 10 female). Demographic and physical characteristics(age, height, weigth, body mass index) were recorded. Evalutions were performed before clinical pilates treatment and after 8 weeks clinical pilates treatment. Bath Ankylosing Spondylitis Disease Activity Index(BASDAI) for disease activity, Bath Ankylosing Spondylitis Functional Index(BASFI) for functional capacity, Bath Ankylosing Spondylitis Mobility Index(BASMI) for spinal mobility were used. Balance was evaluated with Biodex Balance System SD. Overall postural stability indices obtained with bilateral stance(stable and unstable platform), single leg stance(stable platform) and overall limits of stability scores were recorded. Static and dynamic endurance tests were used to evaluate core stabilisation. Modified sit-ups test for dynamic core endurance and static core endurance tests recommeded by McGill were used to evaluate core stabilisation. Patients attended group clinical pilates exercise sessions three times a week, during 8 weeks with physotherapist. <h3>Results</h3> The mean age of patients was 43,9±8,93 years and the mean body mass index(BMI) was 27,37±3,68 kg/m<sup>2</sup>. Pre and post treatment measurements were shown in table 1. Statistically significiant improvement were observed in all parameters except stable platform bilateral stance and single leg stance postural stability results(p&lt;0,05). <h3>Conclusions</h3> Clinical pilates exercises is benefical and safety method in patients with AS to improve functional capasity, disease activity, spinal mobility, core stabilisation and balance. Clinical pilates is an enjoyable and effective way to exercise for Ankylosing Spondylitis patients. <h3>Reference</h3> [1] Altan L, et al. Effect of Pilates training on people with ankylosing spondylitis. Rheumatology international2012.32(7):2093–2099. <h3>Disclosure of Interest</h3> None declared
Stimuli-Responsive Nanotheranostics for Real-Time Monitoring Drug Release by Photoacoustic Imaging
Authors: Zhen Yang, Jibin Song, Wei Tang, Wenpei Fan, Yunlu Dai, Zheyu Shen, Lisen Lin, Siyuan Cheng, Yijing Liu, Gang Niu, Pengfei Rong, Wei Wang, Xiaoyuan Chen
Journal: Theranostics (2019)

Molecular photoacoustic imaging (PA) is a promising technology to understand tumor pathology and guide precision therapeutics. Despite the capability of activatable PA probes to image tumor-specific biomarkers, limitations in their molecular structure hamper them from effective drug delivery and the drug release monitoring. Herein, we developed a perylene diimide (PDI) based theranostic platform that provides noninvasive PA imaging signals to monitor tumor-specific pH-responsive drug release. Methods: we first designed and synthesized an acid-responsive amine-substituted PDI derivative. The pH sensitive properties of the PDI was demonstrated by density functional theory (DFT) calculations, UV-vis experiments and PA studies. The theranostic platform (THPDINs) was fabricated by self-assembly of the acid-responsive PDI, a pH irrelevant IR825 dye, and anti-cancer drug doxorubicin (DOX). The PA properties in various pH environment, drug delivery, cytotoxicity, cell uptake, ratiometric PA imaging and anti-tumor efficacy of the THPDINs were investigated in vitro and in vivo by using U87MG glioma cell line and U87MG tumor model. Results: We found that our designed PDI was sensitive to the tumor specific pH environment, reflected by absorbance shift, PA intensity and aggregation morphology changes in aqueous solution. The as-synthesized pH sensitive PDI acted as a molecular switch in the THPDINs, in which the switch can be triggered in the mild acidic tumor microenvironment to accelerate DOX release. Meanwhile, the DOX release could be monitored by ratiometric PA imaging. Conclusions: We developed a multifunctional PDI based theranostic platform for noninvasive real-time ratiometric PA imaging of tumor acidic pH and monitoring of drug release in living mice simultaneously. This strategy will shed light on the development of smart activatable theranostic nanoplatforms and will significantly advance the application of PA theranostics in biology and medicine.
Cancer: more young people in England are surviving
Authors: Susan Mayor
Journal: BMJ (2019)

Mortality and five year survival rates have improved in a range of different cancers in young people aged 13-24 in England, an overview of cancer trends has shown.1

“This new report shows for the first time that cancer survival rates are improving in young people,” said Kate Collins, chief executive of the Teenage Cancer Trust, which funded the research with Public Health England.

She added, “This hugely positive shift has occurred since the National Institute for Health and Care Excellence decided in 2005 to recognise and treat teenagers and young adults …
AB0949 Serum 25-hydroxyvitamin d status in patient with psoriatic arthritis
Authors: S. Tsuji, J. Hashimoto, T. Noguchi, S. Akita, K. Yachi, S. Ohshima, Y. Saeki, M. Higashiyama
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Vitamin D has been recognised not only in calcium metabolism and bone metabolism but also in the physiological activities of a wide variety of cells, and its deficiency is caused by fractures/falls, osteoporosis and other various disease risks have been reported. <h3>Objectives</h3> To clarify vitamin D satisfaction status of patients with PsA, which is one of spondyloarthritis, by measuring serum 25OHD concentration. <h3>Methods</h3> 180 patients with PsA satisfying CASPAR criteria during the visit to our hospital between <sup>August 2016</sup> and June 2017, 125 males, averaging age 54.1 y.o., BMI average 24.2, mean disease duration of PsA and psoriasis were 8.1 years, 19.3 years, respectively. The type of psoriatic arthritis was 79 spondylitis type and 101 peripheral type. MTX was 51.7% as an agent for treating PsA, and the average dose was 8.3±3.1 mg/week. The number of biologics use was 37.2%. There were 9 cases of osteoporosis and 21 cases of osteopenia, 20 patients who were undergoing treatment for osteoporosis, and all patients were treated with activated VD3. 110 patients (61.1%) had active type VD3 paint applied to psoriasis eruption. The ACPA positive rate was 7.4%, the rheumatoid factor positive was 17.7%, and average CRP was 0.25±0.36 mg/dl. The test method for the serum 25OHD concentration was measured with the CLIA antibody method (SRL, Inc.). Regarding the judgment criteria of deficiency, although various discussions are in progress, "the index of serum 25OHD deficiency less than 20 ng/ml" prepared by the institute of medicine (IOM) in 2011 was used. As a study item, firstly, the degree of satisfaction of vitamin D using serum 25OHD concentration was determined. Second, it divided into VD deficient group and non-deficient group age, sex, disease duration, psoriatic arthritis type, blood biochemical test, presence of active VD administration, presence or absence of active type VD coating for skin, presence or absence of MTX · BIO, Osteoporosis · Percentage of osteopenia · The presence or absence of vulnerability fracture history was compared between both groups. <h3>Results</h3> Mean serum 25OHD concentration in patients with PsA was 16.4±6.3 ng/ml and serum 25OHD deficiency was observed in 134cases (74.4%). Factors that showed significant differences between the two groups (VD deficient group/normal group) were age (54.4/59.0y.o. p=0.032), gender (female rate) 35.0%/11.9%: p=0.040, ACPA negative rate 97.0%/85.2%: p=0.010, serum MMP-3 (69.0/98.4 ng/ml p=0.030), active vitamin D top coating use rate for skin 54.0%/88.9%: p=0.001, Biologics treatment rate 49.3%/11.1%: p&lt;0.001. <h3>Conclusions</h3> 74.4% of patients with PsA had vitamin D deficiency. In the vitamin d-deficient group, low age, high female rate, ACPA negative, low serum MMP-3, VD coating low use rate for skin, biological product high usage rate were significant. <h3>Disclosure of Interest</h3> None declared
A Magnetically Assembled High‐Aspect‐Ratio Needle Electrode for Recording Neuronal Activity
Authors: Taiki Yasui, Shota Yamagiwa, Hirohito Sawahata, Shinnosuke Idogawa, Yoshihiro Kubota, Yuto Kita, Koji Yamashita, Rika Numano, Kowa Koida, Takeshi Kawano
Journal: Advanced Healthcare Materials (2019)

Abstract Microelectrode devices, which enable the detection of neuronal signals in brain tissues, have made significant contributions in the field of neuroscience and the brain–machine interfaces. To further develop such microelectrode devices, the following requirements must be met: i) a fine needle's diameter (&lt;30 µm) to reduce damage to tissues; ii) a long needle (e.g., ≈1 mm for rodents and ≈2 mm for macaques); and iii) multiple electrodes to achieve high spatial recording (&lt;100 µm in pitch). In order to meet these requirements, this study herein reports an assembly technique for high‐aspect‐ratio microneedles, which employs a magnet. The assembly is demonstrated, in which nickel wires of length 750 µm and diameter 25 µm are produced on a silicon substrate. The impedance magnitude of the assembled needle‐like electrode measured at 1 kHz is 5.6 kΩ, exhibiting output and input signal amplitudes of 96.7% at 1 kHz. To confirm the recording capability of the fabricated device, neuronal signal recordings are performed using mouse cerebra in vivo. The packaged single microneedle electrode penetrates the barrel field in the primary somatosensory cortex of the mouse and enables the detection of evoked neuronal activity of both local field potentials and action potentials.
Upregulation of miR-489-3p and miR-630 inhibits oxaliplatin uptake in renal cell carcinoma by targeting OCT2
Authors: Lu Chen, Le Chen, Zhiyuan Qin, Jinxiu Lei, Sheng Ye, Kui Zeng, Hua Wang, Meidan Ying, Jianqing Gao, Su Zeng, Lushan Yu
Journal: Acta Pharmaceutica Sinica B (2019)

Renal cell carcinoma (RCC) is one of the most common malignant tumors affecting the urogenital system, accounting for 90% of renal malignancies. Traditional chemotherapy options are often the front-line choice of regimen in the treatment of patients with RCC, but responses may be modest or limited due to resistance of the tumor to anticarcinogen. Downregulated expression of organic cation transporter OCT2 is a possible mechanism underlying oxaliplatin resistance in RCC treatment. In this study, we observed that miR-489-3p and miR-630 suppress OCT2 expression by directly binding to the OCT2 3′-UTR. Meanwhile, via 786-O-OCT2-miRNAs stable expression cell models, we found that miRNAs could repress the classic substrate 1-methyl-4-phenylpyridinium (MPP+), fluorogenic substrate N,N-dimethyl-4-(2-pyridin-4-ylethenyl) aniline (ASP+), and oxaliplatin uptake by OCT2 both in vitro and in xenografts. In 33 clinical samples, miR-489-3p and miR-630 were significantly upregulated in RCC, negatively correlating with the OCT2 expression level compared to that in adjacent normal tissues, using tissue microarray analysis and qPCR validation. The increased binding of c-Myc to the promoter of pri-miR-630, responsible for the upregulation of miR-630 in RCC, was further evidenced by chromatin immunoprecipitation and dual-luciferase reporter assay. Overall, this study indicated that miR-489-3p and miR-630 function as oncotherapy-obstructing microRNAs by directly targeting OCT2 in RCC.
SP0086 Occupational physical activities and knee osteoarthritis
Authors: D Coggon
Journal: Annals of the Rheumatic Diseases (2001)

<h3></h3> Assessing the contribution of occupational activities to knee osteoarthritis presents several methodological difficulties. Nevertheless, a strong body of evidence has accumulated that the disease is more common in people who have carried out heavy physical work, and particularly in those whose work has entailed prolonged or repeated kneeling or squatting. The precise definition of occupational kneeling and squatting has varied between studies, but relative risks have often been two or higher. It seems likely that the hazard arises from unusual mechanical stresses on the joint, and it is notable that the same occupational activities have also been linked with degenerative tears of the menisci. In addition, some occupations such as professional footballers carry a risk of acute meniscal injury which may later lead to osteoarthritis. The challenge now is to translate these epidemiological observations into effective policies for the prevention of disease. In most developed countries, the requirement for heavy physical work has declined over recent decades as a consequence of increasing mechanisation. However, there are still many jobs that involve kneeling or squatting. Often, as for example in the construction industry, the work work environment is difficult to control and the hazardous tasks cannot easily be eliminated or substituted. Knee pads may be used to reduce discomfort and protect against pre-patellar bursitis, but as yet we have no evidence that they reduce the risk of osteoarthritis. Another approach might be to identify individuals who are at unusually high risk from kneeling because of the concomitant presence of other risk factors. For example, in a recent case-control study, the interaction of occupational kneeling with obesity was approximately multiplicative. It follows that the absolute reduction in risk from avoidance of obesity would be greater in workers who have to kneel in their jobs. Where the combination of occupational kneeling with other risk factors leads to exceptionally high risk, there may even be a case for selectively excluding such individuals from certain jobs.
Clinical and Molecular Models of Prognostication in Mastocytosis: Analysis Based on 580 Consecutive Cases
Authors: Animesh Pardanani, Yoseph Elala, Sahrish Shah, Terra L. Lasho, Mrinal M. Patnaik, Darci Zblewski, Rhett P. Ketterling, Curtis A. Hanson, Ayalew Tefferi
Journal: Blood (2018)
Heart failure prognosis over time: how the prognostic role of oxygen consumption and ventilatory efficiency during exercise has changed in the last 20 years
Authors: Stefania Paolillo, Fabrizio Veglia, Elisabetta Salvioni, Ugo Corrà, Massimo Piepoli, Rocco Lagioia, Giuseppe Limongelli, Gianfranco Sinagra, Gaia Cattadori, Angela B. Scardovi, Marco Metra, Michele Senni, Alice Bonomi, Domenico Scrutinio, Rosa Raimondo, Michele Emdin, Damiano Magrì, Gianfranco Parati, Federica Re, Mariantonietta Cicoira, Chiara Minà, Michele Correale, Maria Frigerio, Maurizio Bussotti, Elisa Battaia, Marco Guazzi, Roberto Badagliacca, Andrea Di Lenarda, Aldo Maggioni, Claudio Passino, Susanna Sciomer, Giuseppe Pacileo, Massimo Mapelli, Carlo Vignati, Francesco Clemenza, Simone Binno, Carlo Lombardi, Pasquale Perrone Filardi, Piergiuseppe Agostoni
Journal: European Journal of Heart Failure (2019)
Impact of single-room contact precautions on hospital-acquisition and transmission of multidrug-resistant Escherichia coli: a prospective multicentre cohort study in haematological and oncological wards
Authors: L.M. Biehl, P. Higgins, T. Wille, K. Peter, A. Hamprecht, S. Peter, D. Dörfel, W. Vogel, H. Häfner, S. Lemmen, J. Panse, H. Rohde, E.-M. Klupp, P. Schafhausen, C. Imirzalioglu, L. Falgenhauer, J. Salmanton-García, M. Stecher, J.J. Vehreschild, H. Seifert, M.J.G.T. Vehreschild
Journal: Clinical Microbiology and Infection (2019)
Abstract 13707: Psychometric Testing of the Self-Care of Chronic Angina Index (SCCAI)
Authors: Victoria Dickson, Christopher Lee, Karen Yehle, Ken Faulkner, Ana Mola, Barbara Riegel
Journal: Circulation (2015)

Coronary heart disease (CHD) requires a significant amount of self-care conceptualized as a process of treatment adherence (self-care maintenance) and symptom response (self-care management).Yet, there are no instruments that measure self-care in this population. Purpose: To test the psychometric properties of the Self-Care of Chronic Angina Index (SCCAI). Methods: A sample of 392 adults with CHD (e.g., history of MI, angina) completed the SCCAI and the General Adherence Scale (GAS). Multidimensional factor analysis was used to identify item structure. Factor determinacy scores (FDS) were computed for multidimensional scales. Cronbach’s alpha and FDS were computed for unidimensional scales. Validity was tested using correlations to test associations between observed domains of self-care and adherence (GAS). Results: 62% of the sample was male; mean age 61.4±9.6 years; mean duration of CHD 7±10 years. A multidimensional self-care maintenance factor entailed “consultative behaviors” (keep appointments, take aspirin and medicines as prescribed, check blood pressure, use medication reminder system, and avoid smoking/smokers) and “autonomous behaviors” (exercise, ask for low sodium foods, eat fruits/vegetables, and try to lose weight) (FDS = 0.83). A multidimensional self-care management factor entailed “immediate recognition and response” (recognize symptoms, reduce activity and take nitroglycerine) and “delayed response” (call doctor, take aspirin and evaluate treatment effectiveness) (FDS = 0.74). A unidimensional confidence factor captured patients’ self-efficacy in following treatment advice, and recognizing, evaluating and treating symptoms (α=0.84, FDS = 0.91). Consultative (r=0.89) and autonomous (r=0.82) behaviors, immediate recognition and response (r=0.86), delayed response behaviors (0.79) and confidence (r=0.27) were associated with adherence (all p&lt;0.001). Conclusion: The findings support the conceptual basis of self-care in patients with CHD as a process of maintenance, i.e. consultative and autonomous behaviors, and management, with symptom awareness and response. The SCCAI confidence scale as a measure of self-efficacy can be used to identify behaviors to target in future interventions.
OP0138 Investigation of biopsychosocial assessments in patients with rheumatic disease
Authors: N.B. Karaca, G. Arın, A. Özçadırcı, F.B. Oflaz, S. Apra&scedil; Bilgen, E. Ünal
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> The daily living activities, functions, depression and anxiety of patients with rheumatic diseases can be affected at various levels.<sup>1</sup> This condition explains the biopsychosocial dimension of chronic pain, it also requires the multidimensional assessment of the disease.<sup>2</sup> <h3>Objectives</h3> The aim of this study was to investigate biopsychosocial assessments of patients with rheumatic diseases. <h3>Methods</h3> Patients with rheumatic diseases were included in this prospective study. Demographic informations of patients were recorded. Health Assessment Questionnaire (HAQ) was used to assess daily living activities, the Hospital Anxiety and Depression Scale (HADS) was used to assess the anxiety and depression levels and Cognitive Exercise Therapy Approach Scale (the authors request that the abbreviation stay as 'BETY' as the original in Turkish) was used to assess biopsychosocial status of the patients.<sup>3</sup> Data obtained from 352 patients were analysed by correlation analysis. <h3>Results</h3> 352 patients (82.4% women, 17.6% men, mean age: 46.01±11.6 years) were included in this study. Descriptives of the assessment results were given in table 1. There was a statistically significant correlation between the BETY and the anxiety and depression subscales of HADS, respectively, strong and moderately strong, in the positive direction (r=0618 p&lt;0001 and r=0572 p&lt;0,001). A statistically significant, strong correlation was found between the BETY and HAQ scores in the positive direction (r=0650 p&lt;0.001) (table 2). It was observed that patients showed depression characteristics according to HADS cut-off values (&gt;7). <h3>Conclusions</h3> It was concluded that the cognitive functions of patients with rheumatic diseases were affected by anxiety-depression levels and daily living activities. Therefore, when the patient changes his/her cognition about his/her illness, it is thought that anxiety and depression levels may change positively. It was decided that the cognitive functions of the patients should be emphasised in the assessment of rheumatic patients. <h3>References</h3> [1] Anyfanti P, Gavriilaki E, Pyrpasopoulou A, Triantafyllou G, Triantafyllou A, Chatzimichailidou S, et al. Depression, anxiety, and quality of life in a large cohort of patients with rheumatic diseases: Common, yet undertreated. Clinical rheumatology2016;35(3):733–9. [2] Booth J, Moseley GL, Schiltenwolf M, Cashin A, Davies M, Hubscher M. Exercise for chronic musculoskeletal pain: A biopsychosocial approach. Musculoskeletal Care2017;15(4):413–21. [3] Ünal E, Arin G, Karaca Nb, Kiraz S, Akdo&amp;gbreve;an A, Kalyoncu U, et al. Romatizmalı hastalar için bir ya&amp;scedil;am kalitesi ölçeıinin geli&amp;scedil;tirilmesi: Madde havuzunun olu&amp;scedil;turulması. <i>Journal of Exercise Therapy and Rehabilitation</i>2017;4(2):67–75. <h3>Disclosure of Interest</h3> None declared