SAT0622B SERUM URIC ACID LEVELS WERE INDEPENDENTLY ASSOCIATED WITH AORTIC ARCH CALCIFICATION IN MIDDLE-AGED AND ELDERLY CHINESE POPULATION
Authors: Wei Yan, Aishu Luo, Shiyu Lin, Jianan Wang, Jintao Jiang, Fang Wang, Wenfeng Tan
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background:</h3> Aorta calcification are considered markers of subclinical atherosclerotic disease that are independent predictors of subsequent cardiovascular events. A growing number of studies have shown that serum uric acid is associated with the development of cardiovascular diseases. <h3>Objectives:</h3> The main purpose of this study was to investigate the prevalence of aorta calcification and to determine the relationship between the levels of serum uric acid and aorta calcification in the middle-aged and elderly population. <h3>Methods:</h3> From Jan 2018 to Dec 2018, totally 6152 consecutive participants aged &gt;50 years old underwent annual health survey were included in this study. Detailed physical examination was performed as well as a thorough review from structured questionnaires, which in baseline demographics and medical history including alcohol consumption, smoking and physical activity status, BMI, blood pressure, blood glucose and serum lipid were all collected and recorded. Aortic calcification was analyzed by chest X-ray. All data were analyzed retrospectively. <h3>Results:</h3> The prevalence of aortic arch calcification was 13.9% in these 6152 participants with age &gt;50 years and was equally common in men and women. Aortic arch calcification prevalence was significantly increased in populations with hyperuricemia (defined as serum uric acid &gt;420 umol/L), as compared with populations with normal serum uric acid levels (defined as serum uric acid ≤ 420 umol/L) (83.39% vs. 16.61%, <i>p</i> &lt; 0.001). Participants were divided into three groups according to their uric acid levels.A more prevalent aortic arch calcification was identified in high uric acid level group than those in middle or low uric acid level group (p &lt; 0.05). On logistic regression analysis, serum uric acid levels were found to be independently associated with aortic arch calcification (OR=1.469, 95%CI: 1.199∼1.800, P&lt;0.01) in these participants. <h3>Conclusion:</h3> Serum uric acid levels were independently associated with aortic arch calcification in middle-aged and elderly Chinese population. These results may suggest the need for more aggressive actions for urate lowering therapy in middle-aged and elderly hyperuricemia patients, especially in patients coexist with other cardiovascular disease risks. <h3>References</h3> [1] Gertler MM, Garn SM, Levine SA. Serum uric acid in relation to age and physique in health and in coronary heart disease. Ann Intern Med. 1951;34:1421–1431. [2] Fang J, Alderman MH. Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971–1992. National health and nutrition examination survey. JAMA. 2000;283:2404– 2410. [3] Wheeler JG, Juzwishin KD, Eiriksdottir G, et al. Serum uric acid and coronary heart disease in 9,458 incident cases and 155,084 controls: prospective study and meta-analysis. PLoS Med. 2005;2:e76. [4] Culleton BF, Larson MG, Kannel WB, Levy D. Serum uric acid and risk for cardiovascular disease and death: the Framingham heart study. Ann Intern Med. 1999;131:7–13. [5] 5.Moriarity JT, Folsom AR, Iribarren C, et al. Serum uric acid and risk of coronary heart disease: Atherosclerosis Risk in Communities (ARIC) study. Ann Epidemiol. 2000;10:136–143. <h3>Disclosure of Interests:</h3> None declared