tbuckley/cabot-search huggingface dataset:
126TiP Tailored axillary surgery with or without axillary lymph node dissection followed by radiotherapy in patients with clinically node-positive breast cancer (SAKK 23/16 / IBCSG 57-18 / ABCSG-53 / GBG 101 - TAXIS): A multicenter randomized phase III trial
Authors: W.P. Weber, G. Henke, K. Ribi, S. Hayoz, S. Seiler, C. Maddox, T. Ruhstaller, D. Zwahlen, S. Muenst, M. Ackerknecht, F. Fitzal, Z.T. Matrai, M. Újhelyi, C. Kurzeder, L. Lelièvre, C.J. Tausch, J. Heil, M. Knauer
Journal: Annals of Oncology (2020)
The Diagnostic Tripod
Authors: Samuel Vaisrub
Journal: JAMA (1974)

When a patient with angina exhibits characteristic S-T depressions on the electrocardiogram and evidence of vessel obstruction on the coronary angiogram, the diagnosis of coronary heart disease is not in doubt. Yet, what if the clinical, electrophysiologic, and roentgenographic findings are discordant? What if the ECG is normal and the arteriogram is not, or vice versa? What if both are normal, but the patient continues to have incapacitating chest pain? It would appear that the three diagnostic criteria do not carry equal measures of importance. Pain, being subjective, receives the least weight. True, patients were known to suffer acute myocardial infarction shortly after being cleared by objective evidence. They were, however, considered exceptions to the general rule. An abnormal exercise ECG is taken more seriously. Before the advent of coronary angiography, positive results from a Master step test or a treadmill exercise test could make the difference between a diagnosis
112TiP SOLTI-1710 PROMETEO II: Palbociclib in combination with letrozole in patients with hormone receptor-positive (HR+)/HER2-negative residual disease after standard neoadjuvant chemotherapy (NAC)
Authors: E.M. Ciruelos, X. González-Farré, A. Perelló, E. Alba, P. Palacios-Ozores, J. Salvador-Bofil, M. Merino, P. Villagrasa, P. Celiz, T. Pascual, A. Prat, S. Pernas Simon
Journal: Annals of Oncology (2020)
Personalized neoantigen vaccination with synthetic long peptides: recent advances and future perspectives
Authors: Xiaotong Chen, Ju Yang, Lifeng Wang, Baorui Liu
Journal: Theranostics (2020)

Therapeutic cancer vaccines are one of the most promising strategies of immunotherapy.Traditional vaccines consisting of tumor-associated antigens have met with limited success.Recently, neoantigens derived from nonsynonymous mutations in tumor cells have emerged as alternatives that can improve tumor-specificity and reduce on-target off-tumor toxicity.Synthetic peptides are a common platform for neoantigen vaccines.It has been suggested that extending short peptides into long peptides can overcome immune tolerance and induce both CD4 + and CD8 + T cell responses.This review will introduce the history of long peptide-based neoantigen vaccines, discuss their advantages, summarize current preclinical and clinical developments, and propose future perspectives.
Commentary: Epidemiology for and with a Distrustful Community
Authors: Raymond R. Neutra
Journal: Environmental Health Perspectives (1985)

The epidemiology of diseases associated with chemical waste disposal sites has often been delayed for years after the affected community became aware of the exposure. Frequently, this has resulted in an aroused neighborhood community that is distrustful of those public agencies and officials responsible for protecting their health. It is thus important that positive steps be taken to alleviate the antagonism and to involve the community in an active and constructive role in the epidemiology study. This paper presents a case history of such an incident and highlights some of the lessons learned. The first steps were to involve and inform the community. A citizen and industry advisory committee was formed to participate in the work, publish a newsletter, and conduct regular community meetings. The newsletter and the community meetings were used to identify problems and to explain them; to describe uncertainties of a scientific as well as of political or financial nature; to involve community leaders, including those distrustful; to conduct an epidemiologic census and a neighborhood environmental ex-
14P Evolution of cytotoxic and regulatory T cells in blood and in tissue after neoadjuvant treatment in breast carcinoma
Authors: N. Palazón Carrión, C. Jiménez Cortegana, M.L. Sánchez León, F. Henao Carrasco, E. Nogales Fernandez, V. Sánchez Margalet, L. de la Cruz Merino
Journal: Annals of Oncology (2020)
Abstract 15275: Cardiac Troponin I is Present in Blood of Type 1 and 2 Myocardial Infarction Patients as IC Complex With Little TIC and Free I
Authors: Xander M van Wijk, Stijn Claassen, Nicholas S Enea, Pu Li, Samuel Yang, Marc A Brouwer, G. E Cramer, Robert Zuk, Kara L Lynch, Alan H Wu
Journal: Circulation (2018)

Introduction: Cardiac troponin (cTn) is a complex of three subunits (T, I, C), with some studies reporting that 6-8% is unbound (‘free’) and presumably located in the cytosol. It has been hypothesi...
Belimumab for refractory manifestations of cutaneous lupus: A multicenter, retrospective observational study of 16 patients
Authors: Romain Salle, François Chasset, Diane Kottler, Catherine Picard-Dahan, Arnaud Jannic, Nour Mekki, Tullia De Risi-Pugliese, Jean-Benoît Monfort, Annick Barbaud, Camille Francès, Vincent Descamps
Journal: Journal of the American Academy of Dermatology (2020)
Abstract 13279: Sports Participation and Exercise Restriction of Children With Isolated Bicuspid Aortic Valve
Authors: Marica Baleilevuka-Hart, Kathryn A Carson, William J Ravekes, Teng J Brandon, Kathryn W Holmes
Journal: Circulation (2018)

Introduction: Parents of school age children with bicuspid aortic valve (BAV) frequently ask whether their children will be able to participate in competitive sports during their school age years. ...
Telemonitoring versus standard care in heart failure: a randomised multicentre trial
Authors: Michel Galinier, François Roubille, Philippe Berdague, Gilles Brierre, Philippe Cantie, Patrick Dary, Jean‐Marc Ferradou, Olivier Fondard, Jean Philippe Labarre, Jacques Mansourati, François Picard, Jean‐Etienne Ricci, Muriel Salvat, Lamia Tartière, Jean‐Bernard Ruidavets, Vanina Bongard, Cécile Delval, Guila Lancman, Hélène Pasche, Juan Fernando Ramirez‐Gil, Atul Pathak
Journal: European Journal of Heart Failure (2020)
Advanced biomimetic nanoreactor for specifically killing tumor cells through multi-enzyme cascade
Authors: Wen Liu, Jinpei Wu, Xin Ji, Yandong Ma, Lamei Liu, Xiaoqing Zong, Haiyuan Yang, Jian Dai, Xiaoyuan Chen, Wei Xue
Journal: Theranostics (2020)

Although the enzyme catalytic nanoreactors reported so far have achieved excellent therapeutic efficacy, how to accurately exert enzyme activity in the tumor microenvironment to specifically kill tumor cells and avoid systemic oxidative damage would be an inevitable challenge for catalytic nanomedicine. At the present study, we fabricate an advanced biomimetic nanoreactor, SOD-Fe0@Lapa-ZRF for tumor multi-enzyme cascade delivery that combined specifically killing tumor cells and protect cells from oxidative stress. Methods: We first synthesized the FeNP-embedded SOD (SOD-Fe0) by reduction reaction using sodium borohydride. Next, SOD-Fe0 and Lapa cargo were encapsulated in ZIF-8 by self-assembly. In order to protect the cargo enzyme from digestion by protease and prolong blood circulating time, SOD-Fe0@Lapa-Z was further cloaked with RBC membrane and functionalized with folate targeting, resulting in the final advanced biomimetic nanoreactor SOD-Fe0@Lapa-ZRF. Results: Once internalized, ZIF-8 achieves pH-triggered disassembly in weakly acidic tumor microenvironment. The released SOD-Fe0 and Lapa were further endocytosed by tumor cells and the Lapa produces superoxide anion (O2-•) through the catalysis of NQO1 that is overexpressed in tumor cells, while O2-• is converted to H2O2 via SOD. At this time, the released ferrous ions from SOD-Fe0 and H2O2 are further transformed to highly toxic hydroxyl radicals (•OH) for specifically killing tumor cells, and there was no obvious toxicological response during long-term treatment. Importantly, SOD-Fe0@Lapa-ZRF enhanced the normal cell's anti-oxidation ability, and thus had little effect on the secretion of TNF-α, IL-6 and IL-1β pro-inflammatory cytokines, while effectively reversed the decreased activity of T-SOD and GSH-Px and remained stable MDA content after tumor treatment. In vitro and in vivo results indicate that the tumor microenvironment-responsive release multi-enzyme cascade have high tumor specificity and effective anti-tumor efficacy, and can protect cells from oxidative stress damage. Conclusion: The biomimetic nanoreactor will have a great potential in cancer nanomedicine and provide a novel strategy to regulate oxidative stress.
Predictors of death in patients with diabetes mellitus and ischemic left ventricular dysfunction
Authors: M. Martinelli Filho, M. S. Rocha, G. L. Peixoto, S. F. Siqueira, E. S. Nakahira, W. A. Hueb, L. A. M. Cesar, T. O. Hueb, R. A. Teixeira, R. Costa
Journal: European Journal of Heart Failure (2014)
External Validation of the MEESSI Acute Heart Failure Risk Score
Authors: Desiree Wussler, Nikola Kozhuharov, Zaid Sabti, Joan Walter, Ivo Strebel, Letizia Scholl, Oscar Miró, Xavier Rossello, Francisco Javier Martín-Sánchez, Stuart J. Pocock, Albina Nowak, Patrick Badertscher, Raphael Twerenbold, Karin Wildi, Christian Puelacher, Jeanne du Fay de Lavallaz, Samyut Shrestha, Olivia Strauch, Dayana Flores, Thomas Nestelberger, Jasper Boeddinghaus, Carmela Schumacher, Assen Goudev, Otmar Pfister, Tobias Breidthardt, Christian Mueller
Journal: Annals of Internal Medicine (2019)

The MEESSI-AHF (Multiple Estimation of risk based on the Emergency department Spanish Score In patients with Acute Heart Failure [AHF]) risk score was developed to predict 30-day mortality in patie...
Physician Self-assessment of Shared Decision-making in Simulated Intensive Care Unit Family Meetings
Authors: Scott T. Vasher, Ian M. Oppenheim, Pragyashree Sharma Basyal, Emma M. Lee, Margaret M. Hayes, Alison E. Turnbull
Journal: JAMA Network Open (2020)

<h3>Importance</h3> Professional guidelines have identified key communication skills for shared decision-making for critically ill patients, but it is unclear how intensivists interpret and implement them. <h3>Objective</h3> To compare the self-evaluations of intensivists reviewing transcripts of their own simulated intensive care unit family meetings with the evaluations of trained expert colleagues. <h3>Design, Setting, and Participants</h3> A posttrial web-based survey of intensivists was conducted between January and March 2019. Intensivists reviewed transcripts of simulated intensive care unit family meetings in which they participated in a previous trial from October 2016 to November 2017. In the follow-up survey, participants identified if and how they performed key elements of shared decision-making for an intensive care unit patient at high risk of death. Transcript texts that intensivists self-identified as examples of key communication skills recommended by their professional society's policy on shared decision-making were categorized. <h3>Main Outcomes and Measures</h3> Comparison of the evaluations of 2 blinded nonparticipant intensivist colleagues with the self-reported responses of the intensivists. <h3>Results</h3> Of 116 eligible intensivists, 76 (66%) completed the follow-up survey (mean [SD] respondent age was 43.1 [8.1] years; 72% were male). Sixty-one of 76 intensivists reported conveying prognosis; however, blinded colleagues who reviewed the deidentified transcripts were less likely to report that prognosis had been conveyed than intensivists reviewing their own transcripts (42 of 61; odds ratio, 0.10; 95% CI, 0.01-0.44;<i>P</i> &lt; .001). When reviewing their own transcript, intensivists reported presenting many choices, with the most common choice being code status. They also provided a variety of recommendations, with the most common being to continue the current treatment plan. Thirty-three participants (43%) reported that they offered care focused on comfort, but blinded colleagues rated only 1 (4%) as explaining this option in a clear manner. <h3>Conclusions and Relevance</h3> In this study, guidelines for shared decision-making and end of life care were interpreted by intensivists in disparate ways. In the absence of training or personalized feedback, self-assessment of communication skills may not be interpreted consistently.
158P Patient (pt) demographics, treatment patterns (tx) and hematologic (heme) toxicities among pts with HER2− advanced breast cancer (ABC) and BRCA1/2 mutation(s) (BRCA1/2mut): A multi-country real-world (RW) study
Authors: R. Mahtani, A. Niyazov, K. Lewis, M. Last, A. Rider, B. Arondekar, M.P. Lux
Journal: Annals of Oncology (2020)
Annals Graphic Medicine - Be Calm
Authors: Jesse Powell
Journal: Annals of Internal Medicine (2020)

Web Exclusives2 June 2020Annals Graphic Medicine - Be CalmFREEJesse Powell, MDJesse Powell, MDProvidence Portland Medical Center, Portland, Oregon (J.P.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/G19-0052 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Download figure Download PowerPoint Download figure Download PowerPoint Download figure Download PowerPoint Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: Providence Portland Medical Center, Portland, Oregon (J.P.)Disclosures: The author has disclosed no conflicts of interest. The form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=G19-0052.Author/Illustrator Information: Jesse Powell, MD, is a member of the teaching faculty at the Providence Portland Internal Medicine residency program in Portland, Oregon (e-mail, jesse.[email protected]org).This article was published at Annals.org on 26 May 2020. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 2 June 2020Volume 172, Issue 11Page: W136-W139KeywordsConflicts of interestDisclosureHealth careResidency ePublished: 26 May 2020 Issue Published: 2 June 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Editorial: Restless legs syndrome
Authors: H. H. Hussey
Journal: JAMA (1976)

Except for<i>Current Medical Information and Terminology</i>,<sup>1</sup>standard reference sources (eg, a popular textbook of medicine) are unlikely to reward a seeker of information about restless legs syndrome. In like manner, writings on the subject in medical periodicals are comparatively few. When a practicing physician, uninformed about the malady, is confronted for the first time by a patient who complains of the syndrome, the physician may be mystified. Characteristically, an afflicted person is likely to tell the attending physician that the symptoms are difficult to describe. They are usually most bothersome at night when the patient goes to bed. He may say that his legs feel funny, or heavy (or light) and fidgety. Or, he may resort to saying what the symptoms do<i>not</i>feel like (itching, crawling sensation, warmth, coldness, and so on to the limit of the patient's vocabulary) and will conclude with, "Doctor, unless you've had
Current and Projected Distributions of <i>Aedes aegypti</i> and <i>Ae. albopictus</i> in Canada and the U.S.
Authors: Salah Uddin Khan, Nicholas H. Ogden, Aamir A. Fazil, Philippe H. Gachon, Guillaume U. Dueymes, Amy L. Greer, Victoria Ng
Journal: Environmental Health Perspectives (2020)

Aedes aegypti and Ae. albopictus are mosquito vectors of more than 22 arboviruses that infect humans.Our objective was to develop regional ecological niche models for Ae. aegypti and Ae. albopictus in the conterminous United States and Canada with current observed and simulated climate and land-use data using boosted regression trees (BRTs).We used BRTs to assess climatic suitability for Ae. albopictus and Ae. aegypti mosquitoes in Canada and the United States under current and future projected climates.Models for both species were mostly influenced by minimum daily temperature and demonstrated high accuracy for predicting their geographic ranges under the current climate. The northward range expansion of suitable niches for both species was projected under future climate models. Much of the United States and parts of southern Canada are projected to be suitable for both species by 2100, with Ae. albopictus projected to expand its range north earlier this century and further north than Ae. aegypti.Our projections suggest that the suitable ecological niche for Aedes will expand with climate change in Canada and the United States, thus increasing the risk of Aedes-transmitted arboviruses. Increased surveillance for these vectors and the pathogens they carry would be prudent. https://doi.org/10.1289/EHP5899.
Treatment of Hyperhomocysteinemia in Renal Transplant Recipients
Authors: Andrew G. Bostom, Reginald Y. Gohh, Andrew J. Beaulieu, Marie R. Nadeau, Anne L. Hume, Paul F. Jacques, Jacob Selhub, Irwin H. Rosenberg
Journal: Annals of Internal Medicine (1997)

Background: Stable renal transplant recipients have an excess prevalence of hyperhomocysteinemia, which is a risk factor for arteriosclerosis. Objective: To determine the effect of treatment with 1...
Prevention of Venous Thromboembolism after Knee Arthroplasty
Authors: Jacques R. Leclerc, William H. Geerts, Louis Desjardins, George H. Laflamme, Bernard l'Esperance, Christine Demers, Jeannine Kassis, Moira Cruickshank, Lucinda Whitman, Fernand Delorme
Journal: Annals of Internal Medicine (1996)

Objective: To compare the effectiveness and safety of fixed-dose enoxaparin and adjusted-dose warfarin in preventing venous thromboembolism after knee arthroplasty. Design: A randomized, double-bli...
Validation of the Academic Research Consortium High Bleeding Risk Definition in Contemporary PCI Patients
Authors: Davide Cao, Roxana Mehran, George Dangas, Usman Baber, Samantha Sartori, Rishi Chandiramani, Giulio G. Stefanini, Dominick J. Angiolillo, Davide Capodanno, Philip Urban, Marie-Claude Morice, Mitchell Krucoff, Ridhima Goel, Anastasios Roumeliotis, Joseph Sweeny, Samin K. Sharma, Annapoorna Kini
Journal: Journal of the American College of Cardiology (2020)
Gapless assembly of maize chromosomes using long-read technologies
Authors: Jianing Liu, Arun S. Seetharam, Kapeel Chougule, Shujun Ou, Kyle W. Swentowsky, Jonathan I. Gent, Victor Llaca, Margaret R. Woodhouse, Nancy Manchanda, Gernot G. Presting, David A. Kudrna, Magdy Alabady, Candice N. Hirsch, Kevin A. Fengler, Doreen Ware, Todd P. Michael, Matthew B. Hufford, R. Kelly Dawe
Journal: Genome biology (2020)

Abstract Creating gapless telomere-to-telomere assemblies of complex genomes is one of the ultimate challenges in genomics. We use two independent assemblies and an optical map-based merging pipeline to produce a maize genome (B73-Ab10) composed of 63 contigs and a contig N50 of 162 Mb. This genome includes gapless assemblies of chromosome 3 (236 Mb) and chromosome 9 (162 Mb), and 53 Mb of the Ab10 meiotic drive haplotype. The data also reveal the internal structure of seven centromeres and five heterochromatic knobs, showing that the major tandem repeat arrays (CentC, knob180, and TR-1) are discontinuous and frequently interspersed with retroelements.
Hypoglycemia During Fasting
Authors: Henry T. Ricketts
Journal: JAMA (1975)

Supporters of Women's Lib are noted for ferreting out one thing or another that is not to their liking and putting it to rights—<i>their</i>rights. A while ago, however, it was two male researchers<sup>1</sup>who dug up a heinous negligence that the ladies had missed. One helpful test for insuloma consists of starving the suspect for 72 hours and watching for clinical and chemical signs of hypoglycemia. Our sleuths, interested in measurements of glucose during these tests, found, on going through the literature, that practically no women had had a determination for glucose. Only men had. In women, we must surmise, hypoglycemia was diagnosed by symptoms. After unearthing this shameful oversight, Merimee, of the University of Florida School of Medicine, and Tyson, of the Johns Hopkins University School of Medicine, set about collecting normal women, as well as men, and putting them through their paces, not necessarily to
18P Inter-tumour heterogeneity in breast cancers: The dynamic evolution of cancer genome during the metastatic process
Authors: C. Fumagalli, A. Ranghiero, S. Gandini, F. Corso, S. Taormina, E. De Camilli, G. Viale, M. Barberis, E. Guerini Rocco
Journal: Annals of Oncology (2020)
Mast cells and complement system: Ancient interactions between components of innate immunity
Authors: Daniel Elieh Ali Komi, Farzaneh Shafaghat, Petri T. Kovanen, Seppo Meri
Journal: Allergy (2020)

Abstract The emergence and evolution of the complement system and mast cells (MCs) can be traced back to sea urchins and the ascidian Styela plicata, respectively. Acting as a cascade of enzymatic reactions, complement is activated through the classical (CP), the alternative (AP), and the lectin pathway (LP) based on the recognized molecules. The system's main biological functions include lysis, opsonization, and recruitment of phagocytes. MCs, beyond their classic role as master cells of allergic reactions, play a role in other settings, as well. Thus, MCs are considered as extrahepatic producers of complement proteins. They express various complement receptors, including those for C3a and C5a. C3a and C5a not only activate the C3aR and C5aR expressing MCs but also act as chemoattractants for MCs derived from different anatomic sites, such as from the bone marrow, human umbilical cord blood, or skin in vitro. Cross talk between MCs and complement is facilitated by the production of complement proteins by MCs and their activation by the MC tryptase. The coordinated activity between MCs and the complement system plays a key role, for example, in a number of allergic, cutaneous, and vascular diseases. At a molecular level, MCs and complement system interactions are based on the production of several complement zymogens by MCs and their activation by MC‐released proteases. Additionally, at a cellular level, MCs act as potent effector cells of complement activation by expressing receptors for C3a and C5a through which their chemoattraction and activation are mediated by anaphylatoxins in a paracrine and autocrine fashion.