tbuckley/cabot-search huggingface dataset:
Abstract 15980: Effects of a Concurrent Strength and Endurance Training Program in Diabetes Patients a Randomized Controlled Trial
Authors: Daniela Bassi, Vivian M Arakelian, Renata G Mendes, Flavia C Caruso, José C Bonjorno Júnior, Ross Arena, Audrey Borghi-Silva
Journal: Circulation (2015)

Background: The prevalence of diabetes have increased globally to epidemic proportions; glycemic control and treatment remains a challenge. Concurrent aerobic and resistance training programs (CART) have been widely recommended as an important strategy to improve physiologic and functional performance. Objective: The impact of CART programs on metabolic profile, glycemic control and exercise capacity status in patients with diabetes requires additional study, which is the primary aim of the current study. Materials and Methods: We evaluated 41 patients (15 female and 19 male, 50.8±7 years) with a confirmed diagnosis of diabetes. The subjects were randomized in two groups: sedentary group (SG) and CART group (CART-G). CART was performed 12 weeks, 3 times a week for approximately 1 hour per session (30 minutes aerobic and 30 minutes resistance). Body habitus was assessed by body mass index, waist circumference, and skinfolds. Peripheral muscular strength was evaluated by an isokinetic dynamometer and pulmonary gas exchange was measured breath-by-breath, using a portable telemetric system during maximal incremental exercise testing on a cycle ergometer. Statistical analysis included Shapiro-Wilk test follow by ANOVA two way repeated measures. Results: We observed a decrease in HbA1c (8.1±1.6 to 7.3±1.2%), cholesterol (198.38.1±50.3 to 186.8±35.1 mg/dL) and HOMA IR (6.4±6.8 to 5.0±1.4) in the CART-G compared to the SG. There was no significant difference in fasting plasma glucose. Although body weight did not significantly change after training, skinfold measurements indicated decreased body fat in the CART-G only. CART significantly enhanced muscle strength (p&lt;0.05) (peak torque: 135.5±4 to 159.7±47.7 N.m) compared to the SG (Peak torque: 145.3±47.9 to 143±42.2 N.m). CART was also associated with a significant increase in peak oxygen consumption, from 22.9±6.1 to 27.2±4.7 ml•kg –1 •min –1 compared to the SG, from 21.7±4.5 to 21±3.3 ml•kg –1 •min –1 as well as the maximal workload (124.6±29.1 to 149.9±29 watts) compared to the SG (123.6±36.9 to 122.1±32.9 watts). Conclusion: We concluded that CART is an important intervention strategy, producing both physiologic and functional improvements, in patients with diabetes.
Oral versus Intravenous Antibiotics for Bone and Joint Infection
Authors: Ho-Kwong Li, Ines Rombach, Rhea Zambellas, A. Sarah Walker, Martin A. McNally, Bridget L. Atkins, Benjamin A. Lipsky, Harriet C. Hughes, Deepa Bose, Michelle Kümin, Claire Scarborough, Philippa C. Matthews, Andrew J. Brent, Jose Lomas, Roger Gundle, Mark Rogers, Adrian Taylor, Brian Angus, Ivor Byren, Anthony R. Berendt, Simon Warren, Fiona E. Fitzgerald, Damien J.F. Mack, Susan Hopkins, Jonathan Folb, Helen E. Reynolds, Elinor Moore, Jocelyn Marshall, Neil Jenkins, Christopher E. Moran, Andrew F. Woodhouse, Samantha Stafford, R. Andrew Seaton, Claire Vallance, Carolyn J. Hemsley, Karen Bisnauthsing, Jonathan A.T. Sandoe, Ila Aggarwal, Simon C. Ellis, Deborah J. Bunn, Rebecca K. Sutherland, Gavin Barlow, Cushla Cooper, Claudia Geue, Nicola McMeekin, Andrew H. Briggs, Parham Sendi, Elham Khatamzas, Tri Wangrangsimakul, T.H. Nicholas Wong, Lucinda K. Barrett, Abtin Alvand, C. Fraser Old, Jennifer Bostock, John Paul, Graham Cooke, Guy E. Thwaites, Philip Bejon, Matthew Scarborough
Journal: New England Journal of Medicine (2019)

The management of complex orthopedic infections usually includes a prolonged course of intravenous antibiotic agents. We investigated whether oral antibiotic therapy is noninferior to intravenous antibiotic therapy for this indication.
Impact of adjuvant therapy in patients with a microscopically positive margin after resection for gastroesophageal cancer.
Authors: Lucy Xiaolu Ma, Osvaldo Espin-Garcia, Charles Henry Lim, Peiran Sun, Di Maria Jiang, Hao-Wen Sim, Akina Natori, Bryan Anthony Chan, Daniel Yokom, Stephanie Moignard, Chihiro Suzuki, Eric Xueyu Chen, Geoffrey Liu, Carol Jane Swallow, Gail Elizabeth Darling, Rebecca Wong, Sara Hafezi-Bakhtiari, James Conner, Elena Elimova, Raymond Woo-Jun Jang
Journal: Journal of Clinical Oncology (2019)

164 Background: A microscopically positive (R1) resection margin following resection for gastroesophageal (GE) cancer has been documented to be a poor prognostic factor. The optimal strategy and impact of different modalities of adjuvant treatment for an R1 resection margin remain unclear. Methods: A retrospective analysis was performed for patients (pts) with GE cancer treated at the Princess Margaret Cancer Centre from 2006-2016. Electronic medical records of all pts with an R1 resection margin were reviewed. Kaplan-Meier and Cox proportional hazards methods were used to analyze recurrence free survival (RFS) and overall survival (OS) with stage and neoadjuvant treatment as covariates in the multivariate analysis. Results: We identified 78 GE cancer pts with an R1 resection. 11% had neoadjuvant chemotherapy, 14% chemoradiation (CRT), 75% surgery alone. 28% had involvement of the proximal margin, 13% distal, 56% radial, 3% had multiple positive margins. By the American Joint Committee on Cancer 7 th edition classification, 88% had a pT3-4 tumour, 66% pN2-3 nodal involvement, 64% grade 3, 68% with lymphovascular invasion. 3% were pathological stage I, 21% stage II and 74% stage III. Adjuvant therapy was given in 46% of R1 pts (24% CRT, 18% chemotherapy alone, 3% radiation alone, 1% reoperation). Median RFS for all pts was 12.6 months (95% CI 10.3-17.2). Site of first recurrence was 71% distant, 16% locoregional, 13% mixed. Median OS was 29.3 months (95% CI 22.9-50) for all pts. The 5 year survival rate was 23% (95% CI 12%-43%). There was no significant difference in RFS (log-rank test p= 0.63, adjusted p= 0.14) or OS (log-rank test p= 0.68, adjusted p= 0.65) regardless of adjuvant therapy. Conclusions: Most pts with positive margins after resection for GE cancer had advanced pathologic stage and prognosis was poor. Our study did not find improved RFS or OS with adjuvant treatment and only one pt had reresection. The main failure pattern was distant recurrence, suggesting that pts being considered for adjuvant RT should be carefully selected. Further studies are required to determine factors to select pts with good prognosis despite a positive margin, or those who may benefit from adjuvant treatment.
Immunohistochemical localization of hTERT protein in human tissues
Authors: Pu Yan, Jean Benhattar, Jean-Christoph Stehle, Walter Seelentag, Fred T. Bosman
Journal: Cancer Research (2004)

979   Telomerase is a ribonucleoprotein complex mainly composed of a reverse transcriptase catalytic subunit (hTERT) that copies a template region of its RNA subunit (hTERC) to the end of the telomere. For detecting telomerase activity the TRAP assay is a relatively sensitive and specific method, but it can be used only on fresh tissue extracts and offers no information on a single cell level. Immunohistochemistry (IHC) allows to detect hTERT protein expression at an individual cell level in human tissues. We have tested commercially available anti-hTERT antibodies in formalin fixed and paraffin embedded human tissues by IHC. Only one monoclonal antibody (NCL-hTERT, Novacastra) was sufficiently specific and this was applied to human tissues, in which telomerase activity had been shown by TRAP assay and hTERT mRNA expression by RT-PCR. hTERT protein localized diffusely in the nucleoplasm and more intensively in the nucleoli of cancer cells. Mitotic cells showed cytoplasmic staining. In some tumor subpopulations of cells demonstrated granular cytoplasmic staining, which might be due to alternate splicing of hTERT. In telomerase positive tumors not all the tumor cells showed hTERT immunoreactivity. Double staining with the M30 antibody identified a caspase cleavage product of cytokeratin 18 in the negative cells. We conclude that: 1) hTERT could be detected by IHC in fixed human tissues, but tissue processing and reaction conditions are critical. 2) hTERT protein localizes in the nucleoplasm, more strongly in the nucleolus and occasionally in the cytoplasm, and 3) TRAP positive tumors show significant heterogeneity for hTERT protein expression. We currently explore the mechanisms responsible for heterogeneous hTERT expression in telomerase positive tumor.
Lower risk of gastric atrophy and intestinal metaplasia in MALT lymphoma patients despite of <i>H. pylori</i> infection.
Authors: San Min Lee, Dae Young Cheung, Jin Il Kim, Soo-Heon Park
Journal: Journal of Clinical Oncology (2019)

33 Background: Atrophic gastritis and intestinal metaplasia are sequential consequences of chronic H. pylori infection. H. pylori infection is a well-known risk factor for gastric adenocarcinoma and MALT lymphoma of stomach. Atrophic gastritis and intestinal metaplasia increase the risk of gastric adenocarcinoma development. The relationship between gastric MALT lymphoma and atrophic gastritis-intestinal metaplasia has not been on the spot of interest. We investigated the clinical characteristics of gastric MALT lymphoma and co-presence of atrophic gastritis and intestinal metaplasia. Methods: Study was conducted by review of electronic medical record of patients who were diagnosed with gastric MALT lymphoma at an academic institute, the Yeouido St. Mary's Hospital, Seoul, Korea, from January 2001 to March 2018. Results: A total of 51 subjects were enrolled consecutively during the study period and analyzed retrospectively. The mean age was 57.5-year-old. The male to female ratio was 1.04 (26/25). On histologic examination, background atrophic gastritis was accompanied in 64.7% (33/51). Serum pepsinogen I, II and gastrin level, as serological marker for atrophy, were evaluated in 21 subjects. Thirteen out of 21 (61.9%) were compatible with serological atrophic gastritis (pepsinogen I / II ratio of less than three or pepsinogen I &lt; 70 ng/mL). Conclusions: Prevalence of background mucosal atrophy or intestinal metaplasia was around 60% in patients with gastric MALT lymphoma. This is comparable to that of general population and lower than that of patients with gastric adenocarcinoma. Even though age can be a confounding factor, this result suggests different carcinogenic pathway of gastric MALT lymphoma from adenocarcinoma.
Abstract MP10: Increasing Obesity Prevalence in the United States End-stage Renal Disease Population
Authors: Brittany Shelton, Deanna McWilliams, Rhiannon D Reed, Margaux Mustian, Paul MacLennan, Deirdre Sawinski, Jayme E Locke
Journal: Circulation (2018)

Background: Obesity has become a national epidemic, and is associated with increased risk for comorbid diseases including end-stage renal disease (ESRD). Among ESRD patients, obesity may improve dialysis-survival but decreases likelihood of transplantation, and as such, obesity prevalence may directly impact growth of the incident dialysis population. Methods: Incident adult ESRD patients with complete body mass index (BMI, kg/m 2 ) data were identified from the United States Renal Data System from 01/01/1995-12/31/2010 (n=1,822,598). Data from the Behavioral Risk Factor Surveillance System of the Centers for Disease Control and Prevention (n=4,303,471) represented the US population when weighted. Trends in BMI and obesity classes I (BMI of 30-34.9), II (BMI of 35-39.9), and III (BMI ≥40) were examined by year of dialysis initiation. Trends in median BMI slope were compared between the ESRD and US populations using linear regression. Results: Median BMI of ESRD patients in 1995 was 24.2 as compared to 28.0 in 2010, a 15.7% increase, while the US population’s median BMI increased from 24.2 in 1995 to 25.6 in 2010, a 5.8% increase. Comparable trends were noted with respect to prevalence of obesity classes I, II, and III (Table). BMI increase among the ESRD population was significantly more rapid than among the US population (β: 0.15, 95% CI: 0.14-0.17, p&lt;0.001) (Figure). Conclusion: The median BMI of ESRD patients and prevalence of obesity among ESRD patients is increasing more rapidly than the US population. Given the increased dialysis-survival and decreased likelihood of transplantation associated with obesity, healthcare costs will likely increase, and thus, future research should be directed at examining medical expenditures.
Genome-wide profiling of Epstein-Barr virus integration by targeted sequencing in Epstein-Barr virus associated malignancies
Authors: Miao Xu, Wei-Long Zhang, Qing Zhu, You-yuan Yao, Qi-Sheng Feng, Zhe Zhang, Rou-Jun Peng, Wei-Hua Jia, Gui-Ping He, Lin Feng, Zhao-Lei Zeng, Bing Luo, Rui-Hua Xu, Mu-Sheng Zeng, Wei-Li Zhao, Sai-Juan Chen, Yi-Xin Zeng, Yuchen Jiao
Journal: Theranostics (2019)

Rationale: Epstein-Barr virus (EBV) is associated with multiple malignancies with expression of viral oncogenic proteins and chronic inflammation as major mechanisms contributing to tumor development.A less well-studied mechanism is the integration of EBV into the human genome possibly at sites which may disrupt gene expression or genome stability.Methods: We sequenced tumor DNA to profile the EBV sequences by hybridization-based enrichment.Bioinformatic analysis was used to detect the breakpoints of EBV integrations in the genome of cancer cells.Results: We identified 197 breakpoints in nasopharyngeal carcinomas and other EBV-associated malignancies.EBV integrations were enriched at vulnerable regions of the human genome and were close to tumor suppressor and inflammation-related genes.We found that EBV integrations into the introns could decrease the expression of the inflammation-related genes, TNFAIP3, PARK2, and CDK15, in NPC tumors.In the EBV genome, the breakpoints were frequently at oriP or terminal repeats.These breakpoints were surrounded by microhomology sequences, consistent with a mechanism for integration involving viral genome replication and microhomology-mediated recombination. Conclusion:Our finding provides insight into the potential of EBV integration as an additional mechanism mediating tumorigenesis in EBV associated malignancies.
BF-200 ALA gel vs. MAL cream for BCC
Authors: C.A. Morton, R. Dominicus, P. Radny, T. Dirschka, A. Hauschild, U. Reinhold, R. Aschoff, M. Ulrich, S. Keohane, S. Ekanayake‐Bohlig, S. Ibbotson, R. Ostendorf, C. Berking, D. Gröne, H.J. Schulze, H.M. Ockenfels, V. Jasnoch, H. Kurzen, M. Sebastian, H. Stege, P. Staubach‐Renz, G. Gupta, F. Hübinger, I. Ziabreva, B. Schmitz, A. Gertzmann, H. Lübbert, R.‐M. Szeimies
Journal: British Journal of Dermatology (2018)
COMPARISON OF 4 YEARS CLINICAL OUTCOME OF DRUG-ELUTING STENT IMPLANTATION IN HIGH-ANGLED (≥70°) BIFURCATION AND LOWER-ANGLED (≤70°) BIFURCATION LESION OF UNPROTECTED LEFT MAIN CORONARY ARTERIES
Authors: Sunao Nakamura, Shotaro Nakamura, Hisao Ogawa, Jang-Ho Bae, Yeo H. Cahyadi, Wasan Udayachalerm, Damras Tresukosol
Journal: Journal of the American College of Cardiology (2011)
RUNX1 Mutations Identify an Entity of Blast Phase Chronic Myeloid Leukemia (BP-CML) Patients with Distinct Phenotype, Transcriptional Profile and Drug Vulnerabilities
Authors: Shady Awad, Matti Kankainen, Olli Dufva, Caroline A Heckman, Kimmo Porkka, Satu Mustjoki
Journal: Blood (2018)
Abstract 19635: Anteroposterior Diameter of the Mitral Valve is Associated With Residual Mitral Regurgitation After Isolated Aortic Valve Surgery
Authors: Ryohei Matsuura, Koichi Toda, Shigeru Miyagawa, Yasushi Yoshikawa, Hiroki Hata, Shunsuke Saito, Tetsuya Saito, Koichi Maeda, Keitaro Domae, Noriyuki Kashiyama, Takayoshi Ueno, Toru Kuratani, Yoshiki Sawa
Journal: Circulation (2017)

Introduction: Functional mitral regurgitation (MR) complicated with severe aortic stenosis (AS) is in general reversed after aortic valve replacement (AVR), while residual MR post-AVR is associated...
Five-Year Outcome After Off-Pump or On-Pump Coronary Artery Bypass Grafting in Elderly Patients
Authors: Anno Diegeler, Jochen Börgermann, Utz Kappert, Michael Hilker, Torsten Doenst, Andreas Böning, Marc Albert, Gloria Färber, David Holzhey, Lenard Conradi, Friedrich-Christian Rieß, Philippe Veeckmann, Csaba Minorics, Michael Zacher, Wilko Reents
Journal: Circulation (2019)

The 30-day and 1-year follow-up analysis of the GOPCABE trial (German Off-Pump Coronary Artery Bypass Grafting in Elderly Patients) revealed no significant difference in the composite end point consisting of death, stroke, myocardial infarction, new renal replacement therapy, or repeat revascularization. The 5-year follow-up data of this trial are reported here.From June 2008 to September 2011, a total of 2539 patients aged ≥75 years were randomly assigned to undergo off-pump or on-pump coronary artery bypass grafting (CABG) at 12 centers in Germany. The primary outcome was all-cause mortality at 5 years. The secondary 5-year outcomes were a composite of death, myocardial infarction, and repeat revascularization. Furthermore, the impact of complete versus incomplete revascularization was assessed.After a median follow-up of 5 years, 361 patients (31%) assigned to off-pump CABG and 352 patients (30%) assigned to on-pump CABG had died (hazard ratio off-pump/on-pump CABG, 1.03; 95% CI, 0.89-1.19; P=0.71). The composite outcome of death, myocardial infarction, and repeat revascularization occurred in 397 (34%) after off-pump and in 389 (33%) after on-pump CABG (hazard ratio, 1.03; 95% CI, 0.89-1.18; P=0.704). Incomplete revascularization occurred in 403 (34%) patients randomly assigned to off-pump and 354 (29%) patients randomly assigned to on-pump CABG ( P<0.001). Five-year survival rates were 72% (95% CI, 67-76) with incomplete versus 76% (95% CI, 74-80) with complete revascularization (log-rank test: P=0.02) after off-pump CABG and 72% (95% CI, 67-76) versus 77% (95% CI, 74-80) after on-pump CABG (log-rank test: P=0.03), respectively. Cox regression analysis revealed a hazard ratio incomplete/complete revascularization of 1.19 (95% CI, 1.01-1.39; P=0.04).In elderly patients ≥75 years of age, the 5-year survival rates and the combined outcome of death, myocardial infarction, and repeat revascularization, as well, were similar after on-pump and off-pump CABG. Incomplete revascularization was associated with a lower 5-year survival rate, irrespective of the type of surgery.URL: https://www.clinicaltrials.gov . Unique identifier: NCT00719667.
The Elusive Search for “Best PEEP” and Whether Esophageal Pressure Monitoring Helps
Authors: Alexandre Biasi Cavalcanti, Marcelo Britto Passos Amato, Ary Serpa-Neto
Journal: JAMA (2019)

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Abstract 18542: Functional Tricuspid Regurgitation and Atrial Fibrillation: An Emerging Syndrome
Authors: Filip Ionescu, Erin A Fender, Ioana Petrescu, Vuyisile T Nkomo, Sorin V Pislaru
Journal: Circulation (2017)

Introduction: There is a recognized association between atrial fibrillation (AF) and isolated functional tricuspid regurgitation (FTR). In contrast to FTR related to pulmonary hypertension (PH) and...
Identification of common genetic risk variants for autism spectrum disorder
Authors: Jakob Grove, Stephan Ripke, Thomas D. Als, Manuel Mattheisen, Raymond K. Walters, Hyejung Won, Jonatan Pallesen, Esben Agerbo, Ole A. Andreassen, Richard Anney, Swapnil Awashti, Rich Belliveau, Francesco Bettella, Joseph D. Buxbaum, Jonas Bybjerg-Grauholm, Marie Bækvad-Hansen, Felecia Cerrato, Kimberly Chambert, Jane H. Christensen, Claire Churchhouse, Karin Dellenvall, Ditte Demontis, Silvia De Rubeis, Bernie Devlin, Srdjan Djurovic, Ashley L. Dumont, Jacqueline I. Goldstein, Christine S. Hansen, Mads Engel Hauberg, Mads V. Hollegaard, Sigrun Hope, Daniel P. Howrigan, Hailiang Huang, Christina M. Hultman, Lambertus Klei, Julian Maller, Joanna Martin, Alicia R. Martin, Jennifer L. Moran, Mette Nyegaard, Terje Nærland, Duncan S. Palmer, Aarno Palotie, Carsten Bøcker Pedersen, Marianne Giørtz Pedersen, Timothy dPoterba, Jesper Buchhave Poulsen, Beate St Pourcain, Per Qvist, Karola Rehnström, Abraham Reichenberg, Jennifer Reichert, Elise B. Robinson, Kathryn Roeder, Panos Roussos, Evald Saemundsen, Sven Sandin, F. Kyle Satterstrom, George Davey Smith, Hreinn Stefansson, Stacy Steinberg, Christine R. Stevens, Patrick F. Sullivan, Patrick Turley, G. Bragi Walters, Xinyi Xu, Kari Stefansson, Daniel H. Geschwind, Merete Nordentoft, David M. Hougaard, Thomas Werge, Ole Mors, Preben Bo Mortensen, Benjamin M. Neale, Mark J. Daly, Anders D. Børglum
Journal: Nature Genetics (2019)