tbuckley/cabot-search huggingface dataset:
Abstract 16033: Active or Passive Intradialytic Exercise on Dialysis Efficacy and Cardiovascular Risk Factors in Patients With End-Stage Renal Disease: A Systematic Review and Meta-Analysis
Authors: Filipe Ferrari, Marcelo T Motta, Thiago Dipp, Franklin C Barcellos, Lucas Helal
Journal: Circulation (2018)

Introduction: Patients with ESRD under hemodialysis are at a high risk for CV and overall mortality. Low adequacy of hemodialysis (Kt/V) and the presence of cardiovascular risk factors, such as low...
Outcome and patterns of care in advanced biliary tract carcinoma (ABC): Experience from two tertiary institutions in the United Kingdom.
Authors: Matthew T. Huggett, Helen Passant, Chris Hurt, Stephen P. Pereira, John A. Bridgewater, Somnath Mukherjee
Journal: Journal of Clinical Oncology (2013)

272 Background: The ABC-02 trial has defined the standard therapy for patients with advanced biliary tract cancer (ABC), however outcome in an unselected patient population in the UK has not been described. We report the outcome of a series of patients with ABC from two large UK cancer networks. Methods: We retrospectively reviewed all cases of ABC presenting to two UK cancer networks over a 9-year period. Patients with a diagnosis recorded under anatomical site (liver, gallbladder or biliary tree) or histological diagnosis (cholangiocarcinoma or adenocarcinoma, liver), were included. Any patients who had surgery with curative intent were excluded. Overall survival (OS) and factors influencing OS were assessed. For the analysis, chemotherapy regimens were considered as: (i) gemcitabine (G)-based vs. non-G-based, (ii) platinum (P)-based vs. non-P-based and (iii) fluoropyrimidine (F)-based vs. non-F-based. Results: 402 patients were available for analysis. The median OS was 6.2 months. On univariate analysis, age ≥ 70 years (p=0.047), advanced disease stage (p&lt;0.001), gall bladder primary (p=0.033), poor performance status (p&lt;0.001) and lack of chemotherapy (p&lt;0.001) were associated with worse outcome. Survival was superior in the 36.4% of patients who received palliative chemotherapy (12.5 versus 4.3 months; p&lt;0.001). In patients receiving chemotherapy, on multivariate analysis males had higher mortality than females (HR=1.71; p=0.006) and stage 4 disease had a higher mortality (HR=2.62; p=0.002) than stage 1-2 disease. Patients who did not receive F-based regimens (HR=5.12; p=0.022) or G-based regimens (HR=5.01; p=0.021) had a higher mortality, whereas the effect of P-containing regimens was of borderline significance (HR=2.23; p=0.086). Sites, age, and multi-agent regimens were not significant. Conclusions: This is the first retrospective series from the UK and one of the largest population-based studies in ABC and confirms the benefit of palliative chemotherapy in an unselected group of patients. F-based regimens appear to be as effective as G-based treatments.
Sars-cov-2 hurricane impacting proctology outpatient clinics and proctologic emergencies. On the verge of phase 2, learning from phase 1. correspondence
Authors: G. Gualtieri, L. Brusciano, C. Gambardella, S. Tolone, F.S. Lucido, G. del Genio, G. Terracciano, L. Docimo
Journal: International Journal of Surgery (2020)
Diet and coronary disease.
Authors: Z A LEITNER
Journal: BMJ (1972)

Diet and Coronary DiseaseCoronary artery disease presents us with a problem of alarming proportions.It is already the major cause of death in most affluent communities, and its incidence, particularly among young and middle-aged men, appears to be in- creasing.Unfortunately despite the immense amount of money which has been spent on research in this field we still do not know the cause of the condition or how to prevent it.Many people with raised levels of plasma cholesterol or triglyceride or both are particularly at risk for the de- velopment of coronary artery disease.'Though the epidemiological evidence for the association is convincing, there is no proof that the reduction of serum lipids leads to a cor- responding reduction in risk of myocardial ischaemia.Even
Circulating Giant Tumor-Macrophage Fusion Cells Are Independent Prognosticators in Patients With NSCLC
Authors: Yariswamy Manjunath, Jonathan B. Mitchem, Kanve N. Suvilesh, Diego M. Avella, Eric T. Kimchi, Kevin F. Staveley-O’Carroll, Chelsea B. Deroche, Klaus Pantel, Guangfu Li, Jussuf T. Kaifi
Journal: Journal of Thoracic Oncology (2020)
CONTRIBUTION OF ARGON PLASMA COAGULATION IN THE TREATMENT OF RADIATION PROCTITIS: A RETROSPECTIVE STUDY OF 58 CASES
Authors: S Jamal, M Tamzaourte, A Aourarh
Journal: Endoscopy (2020)

Aims Argon Plasma Coagulation (APC) is a recent endoscopic haemostasis method that has experienced unprecedented growth since its appearance in 1991.It allows the realization of monopolar electrocoagulation without contact with the mucosa treated with an inert gas, colorless, non-flammable and non-toxic. The purpose of our work was to evaluate the interest of APC in the endoscopic management of gastrointestinal bleeding occurring during chronic radiation proctitis hemorrhagic.
BILIOBRONCHIAL FISTULA: RARE COMPLICATION OF HEPATIC HYDATIDOSIS
Authors: A Maktoub, DA Benajah, A Lamine, M Lahlali, H Abid, N Lahmidani, ME Yousfi, Ml Abkari, A Ibrahimi
Journal: Endoscopy (2020)

Introduction The biliothoracic fistula is a fearsome complication of the hydatid cyst ruptured in the thorax because of the lung and hepatic injuries. Its frequency is according around 2.5 to 16%.
ENTRY-AND-EXIT DOUBLE PIG-TAIL DRAINAGE AS SALVAGE OF INEFFECTIVE PRIMARY CLOSURE AND STANDARD DRAINAGE IN BOERHAAVE SYNDROME
Authors: G Salazar, RN Muñoz, EF Valenzuela, RS Ocaña, C de la Serna, M Perez-Miranda
Journal: Endoscopy (2020)

Introduction Primary closure and drainage are management principles of Boerhaave Syndrome (BS). We present a combination of double pig-tail drainage and intraluminal lumen-apposing-metal-stent (LAMS) in a BS patient.
Vericiguat — Another Victory for Targeting Cyclic GMP in Heart Failure
Authors: John C. Burnett
Journal: New England Journal of Medicine (2020)

Pivotal advances in basic scientific investigation have led to innovative drugs that have reduced the burden of cardiovascular disease in humans. There is no better example than the Nobel Prize–winning work of Furchgott, Ignarro, and Murad, who discovered that nitric oxide is an endothelial relaxing factor that mediates its favorable cardiovascular actions with the effector molecule 3′,5′-cyclic guanosine monophosphate (GMP).1 Subsequent studies established that the key target of nitric oxide is activation of soluble guanylyl (sometimes called "guanylate") cyclase, which generates cyclic GMP. Indeed, cyclic GMP has emerged as a key intracellular second messenger that mediates protective cardiovascular, renal, neurohormonal, . . .
RESULTS OF THE EVALUATION OF CLINICAL MANIFESTATION OF SMALL INTESTINE BLEEDING AND ITS SOURCES
Authors: E Ivanova, E Tikhomirova, O Yudin, S Larichev, A Budykina, E Fedorov
Journal: Endoscopy (2020)

Methods From 14.02.2007 to 10.03.2019 229 patients (m-117, f-112, mean age 52,3±18,3 years, range 17-89) were admitted to our clinics with GIB of unknown source. Obscure overt bleeding had 142 (62,0%) pts, obscure occult bleeding - 87 (38,0%) pts, associated with severe anemia in 86 (37,5%) pts, moderate anemia - in 87 (37,9%) pts and mild anemia - in 56 (24,4%) pts. Other complaints were: abdominal pain in 50 (51,0%) pts, diarrhea in 26 (26,5%) pts, nausea/vomiting in 22 (22,4%) pts. Videocapsule enteroscopy was performed in 179 (78,2%) pts, balloon-assisted enteroscopy - in 146 (63,7%) pts.
Repurposing a Pediatric ICU for Adults
Authors: Phoebe H. Yager, Kimberly A. Whalen, Brian M. Cummings
Journal: New England Journal of Medicine (2020)

Repurposing a Pediatric ICU for Adults A Boston hospital transformed its pediatric ICU to treat adult patients. Preserving the original PICU team minimized unnecessary changes to personnel and the ...
ENDOSCOPIC VACUUM THERAPY (EVT) FOR TREATMENT OF ANASTOMOTIC DEHISCENCE AFTER COLORECTAL SURGERY
Authors: SM Milluzzo, M Lovera, P Cesaro, N Olivari, A Bizzotto, C Spada
Journal: Endoscopy (2020)

Aims Anastomotic dehiscence after colorectal surgery is a severe complication. EVT is a promising therapeutic approach. The primary endpoint of this study was to analyze efficacy and feasibility of EVT in the management of anastomotic leakage after colorectal surgery.
COVID-19 in Children With Cancer in New York City
Authors: Farid Boulad, Mini Kamboj, Nancy Bouvier, Audrey Mauguen, Andrew L. Kung
Journal: JAMA Oncology (2020)

COVID-19 in Children With Cancer in New York CityData on the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children, [1][2][3][4] and in children with cancer specifically have been limited.Less than 1% of cases reported from China were in children younger than 10 years. 3 The MSK Kids pediatric program at Memorial Sloan Kettering Cancer Center (MSK) is one of the largest pediatric cancer programs in the US.Starting in mid-March, 2020, we instituted a screening and testing plan to mitigate risk associated with coronavirus disease 2019 (COVID-19).
THE EFFICACY AND SAFETY OF THE SECOND ENDOSCOPIC RADIAL INCISION AND CUTTING METHOD FOR REFRACTORY BENIGN ESOPHAGEAL STRICTURE
Authors: Y Kano, T Kadota, H Sunakawa, K Kumahara, Y Furue, D Sato, T Minamide, Y Yamamoto, K Takashima, K Nakajo, T Murano, K Shinmura, Y Yoda, H Ikematsu, T Yano
Journal: Endoscopy (2020)

Aims Benign esophageal strictures after any treatment of esophageal cancer are often refractory to conventional dilation. Radial incision and cutting (RIC) method is indicated for refractory cases and showed the favorable outcome in the short term. However, some cases develop re-stricture in the long term and RIC is tried to perform repeatedly for such cases. As its efficacy and safety have not been reported yet, we aimed to clarify the efficacy and safety of second RIC.
ADVANCED CHOLANGIOSCOPY GUIDED LITHOTRIPSY IN A PATIENT WITH A BILLROTH II GASTRECTOMY – AN INNOVATIVE SOLUTION
Authors: M Moreira, J Fernandes, T Araújo, H Ribeiro, S Giestas, J Ramada, L Lopes, J Canena
Journal: Endoscopy (2020)

Introduction Endoscopic removal of large CBD stones in patients with Billroth II gastrectomy is difficult and complex.
FEASIBILITY OF ORAL AND DUODENAL MICROBIOTA ANALYSIS OF PANCREATIC CANCER PATIENTS AND CONTROLS
Authors: L Archibugi, MC Petrone, G Rossi, A Mariani, SGG Testoni, G Capurso, PG Arcidiacono
Journal: Endoscopy (2020)

Aims Periodontal disease is a risk factor for pancreatic cancer (PDAC) onset and, recently, there has been evidence for gut bacteria being able to migrate into the pancreas and have a protumorigenic effect. The duodenal microbiota of PDAC cases has been described only in patients with tumor of the head, without taking into considerations the changes of the microbiome due to impaired exocrine pancreatic function or bile flow, thus being a consequence and not a cause of the tumor. The aim of our study was to evaluate the feasibility of oral and duodenal microbiome evaluation in a selected cohort of PDAC patients and controls.
Dominant influence of an HLA-B27 restricted virus-specific CD8+T cell response in viral clearance and viral adaptation in hepatitis C virus infection
Authors: C Neumann-Haefelin, S McKiernan, S Ward, S Viazow, H C Spangenberg, T Killinger, T F Baumert, N Nazarova, F von Weizsacker, A L Roggendorf, D Kelleher, P Klenerman, H E Blum, R Thimme
Journal: Hepatology (2005)
DOUBLE ENDOSCOPE ASSISTED ENDOSCOPIC SUBMUCOSAL DISSECTION FOR TREATING TUMORS IN RECTUM AND DISTAL COLON: A FEASIBILITY STUDY
Authors: A Ebigbo, G Tziatzios, SK Gölder, A Probst, H Messmann
Journal: Endoscopy (2020)

Aims Colorectal Endoscopic submucosal dissection (ESD) is an effective but challenging procedure. To facilitate its performance, several methods that apply traction are available; however, the optimal one remains to be established. Aim of this study was to evaluate the feasibility and safety of the double-endoscope assisted ESD (DEA-ESD) by improving traction to treat complex colorectal lesions.
INTRADUCTAL TUBULOPAPILLARY NEOPLASM (ITPN) AN UNUSUAL PANCREATIC LESION - A CASE REPORT
Authors: M Gonzalez Haba, B Agudo Castillo, F Pons Renedo, C Gonzalez Lois, JPO Rojas, P Ibarrola Arevalo, JLC Panero
Journal: Endoscopy (2020)

EUS revealed a 12 mm, isoechoic, intraductal pancreatic head lesion. ERCP-pancreatoscopy showed a polypoid lesión suggesting intraductal papillary mucinous neoplasm (IPMN).
ENDOSCOPIC TREATMENT OF EARLY LEAKS AND STRICTURES AFTER LAPAROSCOPIC ONE ANASTOMOSIS GASTRIC BYPASS
Authors: F Younis, M Shnell, N Gluck, S Abu-abeid, S Eldar, S Fishman
Journal: Endoscopy (2020)

Aims To summarize our experience with endoscopic treatment of laparoscopic one anastomosis gastric bypass complications.
SAFETY OF EUS FOR PANCREATOBILIARY LESIONS IN PATIENTS IN CIRRHOSIS
Authors: CR Simons-Linares, P Palacios, M Salazar, MA Saleh, H Siddiki, A Bhatt, T Stevens, S Jang, J Vargo, P Chahal
Journal: Endoscopy (2020)

Methods Case control study using the 2016 National Inpatient Sample (NIS) using ICD10-CM codes to identify patients who underwent EUS with and without FNA or FNB for pancreatobiliary solid lesions (PBSL). We compared cirrhotics with non-cirrhotic controls. Primary outcome was rate of procedural complications. Subgroup analysis to compare compensated and decompensated cirrhosis as per validated BAVENO VI classification.
INTESTINAL METAPLASIA IN PATIENTS WITH GASTRO-ESOPHAGEAL JUNCTION TUMORS: SHOULD PATIENTS BE MANAGED DIFFERENTLY?
Authors: I Marques de Sá, A Varelas, A Laranjo, AL Cunha, PP Nunes, MD Ribeiro
Journal: Endoscopy (2020)

Aims Both the incidence for Barrett’s esophagus (BE) and gastro-esophageal junction (GEJ) tumors seems to be increasing. Interestingly, patients with intestinal metaplasia (IM) affecting the distal esophagus (eg BE) or at the GEJ are managed in opposite directions, with follow-up being mandatory for the former and the absence of further care recommended for the later. Also, the management of superficial lesions in GEJ depends on the presence or absence of BE, with EMR or ESD suggested, respectively. We aimed to determine the clinical features and prevalence of premalignant conditions in the surrounding mucosa among patients with GEJ cancer.
EXTRAHEPATIC IMMUNOLOGICAL MANIFESTATIONS IN CHRONIC HEPATITIS-C - ROLE OF HCV SEROTYPES
Authors: J M Pawlotsky, F Roudotthoraval, P Simmonds, J Mellor, M Benyahia, C Andre, M C Voisin, L Intrator, E S Zafrani, J Duval, D Dhumeaux
Journal: Hepatology (1994)
Is aberrant CD8+ T cell activation by hypertension associated with cardiac injury in severe cases of COVID-19?
Authors: Chao Zhang, Fu-Sheng Wang, Jean-Sébastien Silvestre, Fernando Arenzana-Seisdedos, Hong Tang
Journal: Cellular and Molecular Immunology (2020)

COVID-19 global pandemic, caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), 1 has swept 185 countries and regions with more than 2,824,728 confirmed cases, and 197,667 death as on April 25, 2020 according the Coronavirus Resource Center at Johns Hopkins University.Accumulating data suggest that hypertension, diabetes, and cardiovascular diseases are the most frequent comorbidities in COVID-19 patients, and case mortality rates tended to be high in these individuals. 2Among few studies that focus on COVID-19 severe pneumonia, cardiovascular diseases are among the most frequent comorbidities, [3][4][5] with hypertension being the most common (58 of 191 patients, 30%) in one study, exceeding twofold in COVID-19 ARDS patients (23 of 84, 27.4%) more than mild patients (16 of 117, 13.7%) in another study.Angiotensin II (Ang II) is a potent hypertensive hormone, and increased Ang II is associated with hypertension and heart failure, 6 lung 7 and renal dysfunction. 8Angiotensin-converting enzyme 2 (ACE2) converts Ang II to Ang 1-7 to negatively regulate the renin-angiotensin system (RAS) and renin-angiotensin-aldosterone system. 91][12] Notably, SARS-CoV Spike protein engagement can downregulate ACE2 expression and activate RAS for lung injury. 13Furthermore, plasma level of Ang II is markedly elevated and correlated to viral load and lung injury of COVID-19 patients. 14Therefore, reduction of cell surface ACE2, due to SARS-CoV-2 endocytosis, would augment Ang II pathological processes in the development of hypertension, cardiomyopathy, and nephropathy 15 in severe COVID-19 patients.Hypertension is treated with ACE inhibitors and angiotensin II type-I receptor blockers (ARBs), resulting in ACE2 upregulation.It is unclear whether ARB/ACE regime is warranted in COVID-19, due to insufficient evidence at the moment.European Society of Cardiology recommends not to change RAS blockade in COVID-19 patients who are on it, unless adverse clinical indications occur.Further study needs to better understand the impaired RAS in the viral pathogenesis of COVID-19.ACE2 is highly expressed in the heart tissue, implicating a possibly direct viral infection of the myocardium.Strikingly, two independent postmortem examinations revealed no evidence of viral infection or replication in cardiac tissues, albeit pronounced cardiac inflammation exists. 16,17It is unlikely that viral infection and replication directly cause or aggravate cardiac injury in these severe patients.It is becoming recognized that macrophages and T cells infiltrate to the heart in response to hypertension, and the
IS LUMEN-APPOSING METAL STENTS MORE EFFECTIVE THAN PLASTIC STENTS FOR THE MANAGEMENT OF PANCREATIC FLUID COLLECTIONS: AN UPDATED SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: S Tan, C Zhong, Y Peng, X Tang
Journal: Endoscopy (2020)

Aims Recently, a new type of metal stent, named lumen-apposing metal stents (LAMS), has been designed to manage pancreatic fluid collections (PFC), and a few studies have reported its efficacy and safety. Therefore, we conducted this meta-analysis to investigate the role of LAMS for PFC.
Hybrid endoscopic approach for submucosal tunneling septum division for Zenkerʼs diverticulum
Authors: Arunkumar Krishnan, Yervant Ichkhanian, Thomas M. Runge, Mouen A. Khashab
Journal: Endoscopy (2020)

A 71-year-old man was referred for a symptomatic Zenkerʼs diverticulum. The patient had undergone a stapled diverticulotomy 7 years ago. A barium esophagram revealed a 3-cm Zenker’s diverticulum with evidence of staples ([Fig. 1 a]). The decision was made to perform a peroral endoscopic myotomy of Zenker’s diverticulum (Z-POEM).
ENDOSCOPIC TREATMENT OF PATIENTS WITH «DIFFICULT» BILE DUCT STONE DISEASE
Authors: S Budzinskiy, E Fedorov, S Shapovalianz, M Zakharova, P Cherniakevich, E Platonova
Journal: Endoscopy (2020)

Aims To estimate the possibility of mechanical lithotripsy (ML), endoscopic balloon dilation (BD) of post endoscopic sphincterotomy area (post-ERCP area) or combination of these methods in treatment of «difficult» common bile duct stones.
ENDOSCOPIC CLOSURE OF A COLOCUTANEOUS FISTULA AFTER PEG PLACEMENT
Authors: AL Santos, E Rodrigues-Pinto, G Macedo
Journal: Endoscopy (2020)

A 16-year-old boy with medical history of neurofibromatosis type-1 and malignant peripheral nerve sheath tumor underwent PEG tube placement due to dysphagia, anorexia and malnutrition. After PEG replacement, patient started with persistent diarrhea and weight loss. A contrast study revealed a colocutaneous fistula, as contrast infused through the PEG appeared in the colon. For endoscopic closure, fistula edges were fulgurated with argon-plasma and after, we placed two 14/6 mm over-the-scope-clip (OTSC); finally, a detachable snare was placed beneath both OTSC jaws, with the help of a foreign body retrieval forceps. Percutaneous stool leaking completely stopped 2 days later, confirming fistula closure.
ANALYSIS OF PERFORMANCE MEASURES IN SMALL BOWEL CAPSULE ENDOSCOPY (SBCE)
Authors: AC Gomes, R Pinho, A Ponte, A Rodrigues, M Sousa, JC Silva, E Afecto, J Carvalho
Journal: Endoscopy (2020)

Aims The European society of gastrointestinal endoscopy (ESGE) small-bowel working group identified a list of performance measures for small-bowel endoscopy with the final goal of quality improvement. The aim of this study is to analyze the performance measures for small bowel capsule endoscopy (SBCE) at a service level.
Mechanical circulatory support in refractory cardiogenic shock due to influenza virus-related myocarditis
Authors: Jan-Thorben Sieweke, Muharrem Akin, Sebastian Stetskamp, Christian Riehle, Danny Jonigk, Ulrike Flierl, Tobias J. Pfeffer, Valentin Hirsch, Jochen Dutzmann, Marius M. Hoeper, Christian Kühn, Johann Bauersachs, Andreas Schäfer
Journal: European Respiratory Journal (2020)

Background There is scarce evidence for mechanical circulatory support (MCS) in patients with influenza-related myocarditis complicated by refractory cardiogenic shock (rCS). We sought to investigate the impact of MCS using combined veno-arterial extracorporeal membrane oxygenation (VA-ECMO) and micro-axial flow pumps (the ECMELLA concept) in influenza-related myocarditis complicated by rCS. Methods This is a prospective, observational analysis from the single centre HAnnover Cardiac Unloading REgistry (HACURE) from two recent epidemic influenza seasons. We analysed patients with verified influenza-associated myocarditis complicated by rCS who were admitted to our intensive care unit (ICU) on MCS. Subsequently, we performed a propensity score (PS) matched analysis to patients with acute myocardial infarction (AMI) complicated by rCS and non-ischaemic cardiomyopathy (DCM) related rCS. Results We describe a series of seven patients with rCS-complicated influenza-related myocarditis (mean age 56±10 years, 58% male, influenza A (n=2)/influenza B (n=5)). No patient had been vaccinated prior to the influenza season. MCS was provided using combined VA-ECMO and Impella micro-axial flow pump. In two patients with out-of-hospital cardiac arrest, VA-ECMO had been implanted for extracorporeal cardiopulmonary resuscitation. All patients died within 18 days of hospital admission. By PS-based comparison to patients with AMI- or DCM-related rCS and combined MCS, 30-day mortality was significantly higher in influenza-related rCS. Conclusion Despite initial stabilisation with combined MCS in patients with rCS-complicated influenza-related myocarditis, the detrimental course of shock could not be stopped and all patients died. Influenza virus infection potentially critically affects other organs besides the heart, leading to irreversible end-organ damage that MCS cannot compensate for and, therefore, results in a devastating outcome.