tbuckley/cabot-search huggingface dataset:
SAT0116 Efficacy of celecoxib vs ibuprofen and naproxen in the treatment of ankle sprain
Authors: E Ekman, R Petrella, S Levy, C Orevillo, J Fort
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> Ankle sprain is a common acute soft-tissue injury that often results in swelling, pain, inflammation, and ecchymosis. <h3>Objectives</h3> We hypothesised that celecoxib, a COX-2 specific inhibitor, would be as effective as conventional NSAIDs and better than placebo in the treatment of ankle sprain. <h3>Methods</h3> Two separate multicenter, randomised, double-blind studies were conducted: (1) celecoxib 400 mg/d (n = 147) vs ibuprofen 2400 mg/d (n = 155) or placebo (n = 141) over 10 days, and (2) celecoxib 400 mg/d (n = 198) vs naproxen 1000 mg/d (n = 198) over 8 days. Patients had grade 1 or 2 ankle sprains and moderate-to-severe pain on weight bearing [&gt;/= 45 mm, 100-mm VAS] at baseline. <h3>Results</h3> Most patients were male (60% and 67% for ibuprofen and naproxen comparator studies, respectively); mean ages were 31 and 30 years for ibuprofen and naproxen comparator studies, respectively. The first study dose was taken within 48 h after the injury occurred (mean duration: 25.6 and 23.2 hrs for ibuprofen and naproxen comparator studies, respectively). Covariate-adjusted analyses of the primary endpoints (Patient's Global Assessment of Ankle Injury responder rate, and Patient's Assessment of Ankle Pain VAS on weight-bearing) demonstrated that celecoxib was significantly more effective than placebo and as effective as ibuprofen and naproxen in improving the signs and symptoms of ankle sprain. Median times to return to normal function/activity or to improve function by at least 2 grades (5-pt scale) were 5 days for celecoxib-, 6 days for ibuprofen-, and 8 days for placebo-treated patients (celecoxib vs placebo, p = 0.001) in the ibuprofen comparator study and 5 days for both groups in the naproxen comparator study. <h3>Conclusion</h3> Celecoxib is as effective as the maximum recommended dose of ibuprofen and naproxen for pain and superior to placebo in treating ankle sprains. Celecoxib, with its platelet-function-sparing properties, may offer an advantage over ibuprofen and naproxen in managing ankle sprain injuries. Sponsored by Pharmacia Corporation and Pfizer Inc.
Ablation of gut microbiota alleviates obesity-induced hepatic steatosis and glucose intolerance by modulating bile acid metabolism in hamsters
Authors: Lulu Sun, Yuanyuan Pang, Xuemei Wang, Qing Wu, Huiying Liu, Bo Liu, George Liu, Min Ye, Wei Kong, Changtao Jiang
Journal: Acta Pharmaceutica Sinica B (2019)

Since metabolic process differs between humans and mice, studies were performed in hamsters, which are generally considered to be a more appropriate animal model for studies of obesity-related metabolic disorders. The modulation of gut microbiota, bile acids and the farnesoid X receptor (FXR) axis is correlated with obesity-induced insulin resistance and hepatic steatosis in mice. However, the interactions among the gut microbiota, bile acids and FXR in metabolic disorders remained largely unexplored in hamsters. In the current study, hamsters fed a 60% high-fat diet (HFD) were administered vehicle or an antibiotic cocktail by gavage twice a week for four weeks. Antibiotic treatment alleviated HFD-induced glucose intolerance, hepatic steatosis and inflammation accompanied with decreased hepatic lipogenesis and elevated thermogenesis in subcutaneous white adipose tissue (sWAT). In the livers of antibiotic-treated hamsters, cytochrome P450 family 7 subfamily B member 1 (CYP7B1) in the alternative bile acid synthesis pathway was upregulated, contributing to a more hydrophilic bile acid profile with increased tauro-β-muricholic acid (TβMCA). The intestinal FXR signaling was suppressed but remained unchanged in the liver. This study is of potential translational significance in determining the role of gut microbiota-mediated bile acid metabolism in modulating diet-induced glucose intolerance and hepatic steatosis in the hamster.
Engineering Resistance to CD33-Targeted Immunotherapy in Normal Hematopoiesis By CRISPR/Cas9-Deletion of CD33 Exon 2
Authors: Roland B. Walter, Olivier Humbert, George S. Laszlo, Sophie R. Sichel, Christina M. Ironside, Kevin G. Haworth, Olivia M. Bates, Mary E. Beddoe, Ray R. Carillo, Hans-Peter Kiem
Journal: Blood (2018)
Effectiveness of school-based self-management interventions for asthma among children and adolescents: findings from a Cochrane systematic review and meta-analysis
Authors: Dylan Kneale, Katherine Harris, Vanessa M McDonald, James Thomas, Jonathan Grigg
Journal: Thorax (2019)

The evidence that teaching self-management techniques to children and young people with asthma in schools is effective has not, to date, been the subject of systematic review.We conducted a systematic review of intervention studies. Studies were eligible if they employed a randomised parallel-group design and were published in English from 1995 onwards. Participants included children with asthma aged 5-18 years who participated within their own school environment. Searches were conducted on the Cochrane Airways Group Specialised Register. Quantitative data were combined using random-effects meta-analyses.Thirty-three outcome evaluation studies were included. School-based interventions were effective in reducing the frequency of emergency department visits (OR 0.70, 95% CI 0.53 to 0.92; studies=13), and moderately effective in reducing levels of hospitalisations (standardised mean differences [SMD] -0.19, 95% CI -0.35 to -0.04; studies=6). A meta-analysis of three studies suggest that the intervention approach could reduce the number of days of restricted activity (SMD -0.30, 95% CI -0.41 to -0.18; studies=3). However, there was uncertainty as to whether school-based self-management interventions impacted on reducing absences from school.Self-management interventions for children with asthma delivered in schools reduce the number of acute episodes of healthcare usage. We conclude that the school environment is an important space for delivering interventions to improve children's health.
Exercise and Recovery Time for Youth With Concussions
Authors: Sara P. D. Chrisman
Journal: JAMA Pediatrics (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Depression in children: offer digital CBT as first line treatment, says NICE
Authors: Jacqui Wise
Journal: BMJ (2019)

Children and young people with mild depression should be offered digital cognitive behavioural therapy (CBT) as first line treatment, the National Institute for Health and Care Excellence has recommended in draft guidance.1

The recommendation should help young people get faster access to psychological help. There is a huge demand for child and adolescent mental health services (CAMHS), and latest figures from NHS Digital show that one in eight 5-19 year olds had at least one mental disorder in 2017.23

Digital CBT—also known as computer CBT—can be delivered on mobile phones, tablets, and computers. It is already recommended for adults with mild to moderate depression.

The guidelines recommend that children and young people …
Evaluating CAR‐T Cell Therapy in a Hypoxic 3D Tumor Model
Authors: Yuta Ando, Elizabeth L. Siegler, Hoang P. Ta, Gunce E. Cinay, Hao Zhou, Kimberly A. Gorrell, Hannah Au, Bethany M. Jarvis, Pin Wang, Keyue Shen
Journal: Advanced Healthcare Materials (2019)

Despite its revolutionary success in hematological malignancies, chimeric antigen receptor T (CAR-T) cell therapy faces disappointing clinical results in solid tumors. The poor efficacy has been partially attributed to the lack of understanding in how CAR-T cells function in a solid tumor microenvironment. Hypoxia plays a critical role in cancer progression and immune editing, which potentially results in solid tumors escaping immunosurveillance and CAR-T cell-mediated cytotoxicity. Mechanistic studies of CAR-T cell biology in a physiological environment has been limited by the complexity of tumor-immune interactions in clinical and animal models, as well as by a lack of reliable in vitro models. A microdevice platform that recapitulates a 3D tumor section with a gradient of oxygen and integrates fluidic channels surrounding the tumor for CAR-T cell delivery is engineered. The design allows for the evaluation of CAR-T cell cytotoxicity and infiltration in the heterogeneous oxygen landscape of in vivo solid tumors at a previously unachievable scale in vitro.
Abstract 14166: Cardiac Function is Protected From Ischemic Injury in African Spiny Mice
Authors: YanFei Qi, Ravneet Vohra, Juan Zhang, Lei Wang, Eric Krause, Dominic S Guzzo, Glenn A Walter, Michael J Katovich, Malcolm Maden, Mohan K Raizada, Carl J Pepine
Journal: Circulation (2015)

Tissue regeneration is common in crustaceans, insects, reptiles and amphibians. African spiny mice (ASM) evolve to shed a large portion of skin to escape from predators. They have been recently reported as the first mammal to regenerate complete hair follicles, dermis, epidermis, sebaceous glands, adipose tissue, microvessels, smooth muscle, skeletal muscle of the panniculus carnosus and cartilage ( Seifert et al. Nature 2012 ). However, the extent of regenerative ability of ASM with regard to their heart has not been investigated. The objective of this project is to determine the cardiac regenerative potential of ASM relative to another murine species (CD1 mouse) in a coronary artery ligation model. CD1 and ASM were divided into four groups (see table below). Similar ischemic area was induced for group 2 and 4. Cardiac function was assessed using echocardiography and MRI. Briefly, MI led to a 51% decrease in left ventricle ejection fraction (LVEF, 31.9±6.5 vs 64.5±3.7%) in CD1 mice following MI. Whereas, EF was preserved in ASM following MI (78.4±6.5 vs 61.71±1.8%). Collectively, it appears that ASM may be able to preserve and/or regenerate myocardium after ischemic injury. Our findings warrant additional studies to identify molecular pathways and genetic circuits that promote myocardial preservation/regeneration processes.
Association Between Nonalcoholic Fatty Liver Disease and Reduced Bone Mineral Density in Children: A Meta‐Analysis
Authors: Alessandro Mantovani, Davide Gatti, Giacomo Zoppini, Giuseppe Lippi, Enzo Bonora, Christopher D. Byrne, Valerio Nobili, Giovanni Targher
Journal: Hepatology (2019)

Recent cross‐sectional studies have examined the association between nonalcoholic fatty liver disease (NAFLD) and bone mineral density (BMD) in children or adolescents, but these have produced conflicting results. We performed a systematic review and meta‐analysis of these published studies to quantify the magnitude of the association, if any, between NAFLD and BMD. We searched publication databases from January 2000 to September 2018, using predefined keywords to identify relevant observational studies conducted in children or adolescents in whom NAFLD was diagnosed either by imaging or by histology and BMD Z score was measured by dual‐energy X‐ray absorptiometry. Data from selected studies were extracted, and a meta‐analysis was performed using random‐effects modeling. A total of eight observational cross‐sectional or case–control studies enrolling 632 children and adolescents (mean age 12.8 years), 357 of whom had NAFLD, were included in the final analysis. Meta‐analysis showed significant differences in whole‐body or lumbar BMD Z scores between children/adolescents with and without NAFLD (n = 6 studies; pooled weighted mean difference [WMD], –0.48; 95% confidence interval [CI], –0.74 to –0.21; I 2 = 55.5%), as well as between those with biopsy‐confirmed nonalcoholic steatohepatitis (NASH) and those with no‐NASH (n = 4 studies; pooled WMD, –0.27; 95% CI, –0.40 to –0.13; I 2 = 0%). The aforementioned WMDs in BMD Z scores were independent of common clinical risk factors, such as age, sex, race/ethnicity, and body mass index. Sensitivity analyses did not modify these findings. Funnel plot and Egger test did not reveal significant publication bias. Conclusion : This meta‐analysis shows that the presence and severity of NAFLD are significantly associated with reduced whole‐body BMD Z scores in children and adolescents; however, the observational design of the studies included does not allow for proving causality.
Abstract 16253: High Lipoprotein(a) and Low Risk of Major Bleeding in Brain and Airways in the General Population: A Mendelian Randomization Study
Authors: Anne Langsted, Pia R Kamstrup, Børge G Nordestgaard
Journal: Circulation (2017)

Introduction: The physiological role of lipoprotein(a) is unclear; however, lipoprotein(a) may play a role in hemostasis and wound healing. Hypothesis: We tested the hypothesis that high lipoprotein(a) concentrations are associated with low risk of major bleeding in brain and airways, observationally and causally (from human genetics). Methods: We examined 109,169 individuals from the Copenhagen City Heart Study and the Copenhagen General Population study, two similar prospective studies conducted in the Danish general population. Individuals had information on plasma lipoprotein(a) concentrations (n=59,980), LPA kringle-IV type 2(KIV-2) number of repeats (n=98,965), and/or LPA single-nucleotide polymorphism rs10455872 (n=109,169), and all register information on hospital contacts or death due to major bleeding in brain and airways. Results: Using extreme phenotypes or genotypes, the multifactorially adjusted hazard ratio for major bleeding in brain and airways was 0.84(95%CI: 0.71-0.99) for lipoprotein(a...
Mutations in the Ras Pathway in Pre-Treatment Chronic Lymphocytic Leukemia Are Associated with VH1-69: Linking B-Cell Receptor Stereotypy to Downstream Signaling Events
Authors: Dan Jones, Huolin Tu, Jennifer A. Woyach, Kerry A. Rogers, Xiaokang Pan, Susan Long, Brianna Sisson, Sean Caruthers, Peng Ru, Nyla A. Heerema, Gerard Lozanski, Lynne V. Abruzzo, Weiqiang Zhao, John C. Byrd
Journal: Blood (2018)
A phase Ib/II open label study of IMU-131 HER2/Neu peptide vaccine plus cisplatin and either 5-fluorouracil or capecitabine chemotherapy in patients with HER2/Neu overexpressing metastatic or advanced adenocarcinoma of the stomach or gastroesophageal junction.
Authors: Ursula Wiedermann, Anthony J Good, Erika Garner-Spitzer, Yee Chao, Iurie Bulat, Arunee Dechaphunkul, Wichit Arpornwirat, Chaiyut Charoentum, Chia-Jui Yen, Thomas Cheung Yau, Marina Maglakelidze, Suebpong Tanasanvimon, Jedzada Maneechavakajorn, Aumkhae Sookprasert, Li-Yuan Bai, Wen-Chi Chou, Teerapat Ungtrakul, Leslie Chong, Nick Ede
Journal: Journal of Clinical Oncology (2019)

TPS176 Background: Gastric cancer is the 5th most frequently diagnosed cancer and the 3rd leading cause of cancer deaths. HER2/neu is overexpressed in 15% to 25% of patients with gastric cancer and associated with a poor prognosis. Monoclonal antibodies against HER2/neu have been shown to be effective but alternative treatments are needed due to cost and global availability issues. IMU-131 is a B-cell peptide vaccine composed of 3 B cell epitopes derived from the extracellular domain of HER2/neu. Polyclonal antibodies against IMU-131 peptides binding 3 separate regions (DIII, IV) of HER2/neu have been shown to elicit antitumor activity in vitro and a phase I study demonstrated safety and immunogenicity in Her-2 +/++ metastatic breast cancer patients. Fusion of the single peptides into a hybrid peptide conjugated to CRM197 in conjunction with the adjuvant Montanide (P467-CRM-Montanide) improved formulation and stability of the vaccine. With the present Phase 1b/2 trial performed in patients with HER2/neu overexpressing gastric or gastroesophageal junction (GEJ) adenocarcinoma, we hypothesized that administration of IMU-131 in addition to chemotherapy is safe and immunogenic, and will prolong survival and may delay tumor progression and/or reduce tumor burden. Methods: This study is an international open-label multicenter study performed in 16 Asian and Eastern European sites with a maximum of 18 patients enrolled in Phase 1b. This dose escalation study is designed to assess safety, tolerability, immunogenicity and recommended phase 2 dose (RP2D) of IMU-131. Each patient is administered three injections of IMU-131, at a single dose level on Days 0, 14, and 35, accompanied by chemotherapy cycles of cisplatin and 5-fluorouracil or capecitabine every 21 days. The RP2D will be evaluated in the dose expansion Phase 2 study with 68 patients being enrolled. Results: The study is ongoing with the completion of the phase 1b portion in 4Q18. Conclusions: No conclusions can be drawn at this time. Clinical trial information: NCT02795988.
Abstract 15953: Digital Health Intervention in Diabetes
Authors: Conor Senecal, Robert J Widmer, Amir Lerman
Journal: Circulation (2017)

Introduction: Digital health applications are increasingly used to combat chronic disease such as diabetes with mixed results. Hypothesis: Use of a digital health intervention (DHI) in concert with a workplace health program would improve cardiovascular (CVD) risk factors. Methods: We analyzed usage of DHI and change CVD risk factors over one year in 4,128 participants of a work health program across 81 organizations in 42 states. Patients were selected from a larger cohort based on a previous ICD-9 diagnosis of diabetes mellitus (type 1 or type 2). Application users, defined as at least one login, were compared to non-users. Changes in weight, BMI, blood pressure, lipids, fasting glucose and hemoglobin A1c were compared at one year. Results: Users and non-users had significant differences in age, BMI and triglycerides at baseline; however these changes were very modest (Table 1). At one year users of the application had significantly more weight loss (3.11 vs 1.06 lbs.) and reduction in BMI (0.49 vs 0.11...
Abstract 12105: Targeted Delivery of Therapeutic Agents After Myocardial Infarction
Authors: Siva Sai Krishna Dasa, Marc E Seamen, Brent A French, Kimberly A Kelly
Journal: Circulation (2014)

Introduction: Current therapies for heart failure (HF) after myocardial infarction (MI) only slow the progression of LV remodeling and have little capacity to regenerate cardiac muscle lost to MI. To expedite targeted delivery of regenerative therapies post-MI, we hypothesized that suitable targets could be identified by biopanning the heart with a phage display library in a mouse model of MI. Methods: A phage display library was biopanned in vivo to identify peptides specific for the infarct/border zone 4 days post-MI. Fluorescence molecular tomography (FMT) followed by tissue immunofluorescence was performed to interrogate the specificity of phage groups and individual clones with targeted phage at VT680 and neg control phage at VT750. The VT680 fluorophore on the targeted phage clones was then used to identify the cellular targets of those clones by counter-staining with antibodies against cell types of interest. Results: We identified phage clones specific for endothelium, cardiomyocytes, inflammatory fibroblasts and c-Kit+ cells present in the border zone post-MI. Liposomes conjugated with different cell type specific peptides had different accumulation rates in the post-infarct heart as visualized by FMT imaging (Fig. 1a). Immunofluorescence analysis demonstrated cell-type specific association of the targeted liposomes with cells expressing c-Kit, CD31 and Hrnr (Figs. 1b&amp;c). We have also been successful in remote loading of anti-apoptotic and immune suppresive drugs into these liposomes and are currently studying their effect in mice after MI. Conclusions: Peptides identified by this screen enable the targeting of different cell types present in the border zone with different drugs. Identifying the molecular binding partners for these peptides may yield insight into the various events/pathways that evolve after a myocardial infarction.
Once Weekly Versus Twice Weekly Carfilzomib in Combination with Cyclophosphamide and Dexamethasone in Newly Diagnosed Multiple Myeloma: A Pooled Analysis of Two Phase 1/2 Studies
Authors: Sara Bringhen, Roberto Mina, Maria Teresa Petrucci, Lorenzo De Paoli, Stelvio Ballanti, Pellegrino Musto, Massimo Offidani, Stefano Spada, Giulia Benevolo, Elena Ponticelli, Piero Galieni, Michele Cavo, Tommaso Caravita di Toritto, Concetta Conticello, Vittorio Montefusco, Antonio Palumbo, Mario Boccadoro, Alessandra Larocca
Journal: Blood (2018)
Outcomes of Food Allergen Oral Immunotherapy following Clinical Trial Participation
Authors: Melanie M. Makhija, Michelle M. Catalano, Marie L. Doherty, Kathleen M. Beifuss, Jennifer Bosworth, Jennifer C. Howard, Melissa F. Jain, Christine Szychlinski, Rachel Glick Robison, Jacqueline A. Pongracic
Journal: Journal of Allergy and Clinical Immunology (2019)