tbuckley/cabot-search huggingface dataset:
10 Recommendations to Enhance Recruitment, Retention, and Career Advancement of Women Cardiologists
Authors: Garima Sharma, Amy A. Sarma, Mary Norine Walsh, Sharonne N. Hayes, Sheila Sahni, Sherry-Ann Brown, Toniya Singh, Robert A. Harrington, Pamela S. Douglas, Claire S. Duvernoy
Journal: Journal of the American College of Cardiology (2019)

Sex, a biological construct, and gender, a sociocultural construct, both influence the epidemiology and outcomes of various cardiac arrhythmias, leading to disparities that have been observed in clinical practice. Addressing disparities is crucial to improve the quality of clinical care. We recognize gender equality as the ultimate goal to ensuring equitable health care and propose the following strategies to achieve the goal: sex- and gender-stratified research, quality improvement initiatives, implicit bias training, promotion of women into leadership positions in cardiology, peer support, and shared decision-making to help mitigate disparities. However, further research on how to improve the widespread adoption and implementation of such strategies in the clinical setting is required.
TCT-211 Static and Dynamic 3D TEE Automated Aortic Root Modeling Are Both Accurate and Useful to Size the Aortic Annulus in Patients Undergoing TAVR: Comparison to CT
Authors: Shawn Reginauld, Shizhen Liu, Sara Mobasseri, Hassan Sayegh, Vivek Rajagopal, Christopher Meduri, James Kauten, Mani Vannan
Journal: Journal of the American College of Cardiology (2019)
Life is fragile: FMRP controls cell death in liver disease
Authors: Mihael Vucur, Tom Luedde
Journal: Gut (2019)

Acute and chronic liver diseases due to various pathogens have in common that cellular stress and cell death represent their initial triggers. While in acute liver damage and especially in acute liver failure, the loss of functional hepatocytes is the dominant, life-limiting factor, low levels of cell death in chronic diseases like non-alcoholic fatty liver (NASH) or alcoholic liver disease initiate a cascade of immunological cell death responses, driving the progression to liver cirrhosis and finally to hepatocellular carcinoma.1 On a molecular level, hepatocytes that undergo programmed cell death release factors known as danger-associated molecular patterns, which activate immune cells (macrophages) and hepatic stellate cells, and are thus involved in chronic phase transition of liver diseases and decompensation.1 

For years, the term apoptosis was used synonymously with the term ‘programmed cell death’. Nevertheless, this highly simplified dogma was swept away over night when it was discovered that apoptosis was accompanied by several other programmed cell death signalling pathways, and that necrosis was not only a passive form of cell death, for example, in the context of ischaemia, but that …
TCT-712 Infective Endocarditis Caused by Staphylococcus or Enterococcus After Transcatheter Aortic Valve Implantation: A Comparison Between the 2 Most Common Microbiological Findings
Authors: Norman Mangner, Felix Woitek, Stephan Haussig, Lisa Crusius, Georg Stachel, Florian Schlotter, Jennifer Hommel, Philipp Kiefer, Mohamed Abdel-Wahab, Holger Thiele, Michael Borger, David Holzhey, Axel Linke
Journal: Journal of the American College of Cardiology (2019)
Fecal Transplant Doesn’t Improve Symptoms of IBS
Authors: Anita Slomski
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TCT-92 Antegrade LAMPOON (Intentional Percutaneous Laceration of the Anterior Mitral Leaflet to Prevent Outflow Obstruction): A Novel Modification of the Previously Described Retrograde LAMPOON, is a Technically Feasible, Reproducible, Effective, and Safe Modification of This Procedure
Authors: Isida Byku, John Lisko, Jaffar Khan, Robert Guyton, Patrick Gleason, Samuel Maidman, Lucia Alvarez, Kendra Grubb, Norihiko Kamioka, Chandan Devireddy, Toby Rogers, Robert Lederman, Vasilis Babaliaros
Journal: Journal of the American College of Cardiology (2019)
Feasibility of Measuring Face-to-Face Interactions among ICU Healthcare Professionals Using Wearable Sociometric Badges
Authors: Asami Ito-Masui, Eiji Kawamoto, Yuki Nagai, Yuto Takagi, Mami Ito, Noriko Mizutani, Ken’ichi Yano, Kazuo Yano, Hiroshi Imai, Motomu Shimaoka
Journal: American Journal of Respiratory and Critical Care Medicine (2019)
TCT-251 SOS PK Papyrus, an Observational Study of Patients With Covered PK Papyrus Stent.
Authors: Loic Belle, Marco Hernández Enríquez, Hend Madiot, Geraud Souteyrand, Christophe Piot, Ziad Boueri, Edouard Gerbaud, Emmanuel Boiffard, Benoit Lattuca, Philippe Commeau, Richard Gervasoni, Gregoire Range, Nicolas Delarche, Gilles Zemour, Sébastien Levesque, Nicolas Boudou
Journal: Journal of the American College of Cardiology (2019)
Pirfenidone in patients with unclassifiable progressive fibrosing interstitial lung disease: a double-blind, randomised, placebo-controlled, phase 2 trial
Authors: Toby M Maher, Tamera J Corte, Aryeh Fischer, Michael Kreuter, David J Lederer, Maria Molina-Molina, Judit Axmann, Klaus-Uwe Kirchgaessler, Katerina Samara, Frank Gilberg, Vincent Cottin
Journal: The Lancet Respiratory Medicine (2019)
TCT-584 Assessment of Interference Between Pressure-Wire and Coronary Stents Deployed in the Side-Branch: Insights From a Bench Test
Authors: Takayuki Warisawa, Daniel Nour, Henry Seligman, Christopher Rajkumar, Shunichi Doi, Shingo Kuwata, James Howard, Yui Nakayama, Norio Suzuki, Hisao Matsuda, Yoshihiro Akashi
Journal: Journal of the American College of Cardiology (2019)
TCT-125 Impact of Insurance on Outcomes and Readmission Rates in Young Adults After Acute Myocardial Infarction
Authors: Viswajit Reddy Anugu, Srikanth Yandrapalli, Nikhil Nalluri, Bhavi Pandya, Farshid Daneshvar, Roman Royzman, Thomas Vazzana, James Lafferty, Frank Tamburrino, Ruben Kandov
Journal: Journal of the American College of Cardiology (2019)
Association of Prehospital Time to In-Hospital Trauma Mortality in a Physician-Staffed Emergency Medicine System
Authors: Tobias Gauss, François-Xavier Ageron, Marie-Laure Devaud, Guillaume Debaty, Stéphane Travers, Delphine Garrigue, Mathieu Raux, Anatole Harrois, Pierre Bouzat
Journal: JAMA Surgery (2019)

<h3>Importance</h3> The association between total prehospital time and mortality in physician-staffed trauma systems remains uncertain. <h3>Objective</h3> To describe the association of total prehospital time and in-hospital mortality in prehospital, physician-staffed trauma systems in France, with the hypothesis that total prehospital time is associated with increased mortality. <h3>Design, Setting, and Participants</h3> This cohort study was conducted from January 2009 to December 2016. Data for this study were derived from 2 distinct regional trauma registries in France (1 urban and 1 rural) that both have a physician-staffed emergency medical service. Consecutive adult trauma patients admitted to either of the regional trauma referral centers during the study period were included. Data analysis took place from March 2018 to September 2018. <h3>Main Outcomes and Measures</h3> The association between death and prehospital time was assessed with a multivariable model adjusted with confounders. Total prehospital time was the primary exposure variable, recorded as the time from the arrival of the physician-led prehospital care team on scene to the arrival at the hospital. The main outcome of interest was all-cause in-hospital mortality. <h3>Results</h3> A total of 10 216 patients were included (mean [SD] age, 41 [18] years; 7937 men [78.3%]) affected by predominantly nonpenetrating injuries (9265 [91.5%]), with a mean (SD) Injury Severity Score of 17 (14) points. Of the patients, 6737 (66.5%) had at least 1 body region with an Abbreviated Injury Scale score of 3 or more. A total of 1259 patients (12.4%) presented in shock (with systolic pressure &lt;90 mm Hg) and 2724 (26.9%) with severe head injury (Abbreviated Injury Scale score ≥3 points). On unadjusted analysis, increasing prehospital times (in 30-minute categories) were associated with a markedly and constant increase in the risk of in-hospital death. The odds of death increased by 9% for each 10-minute increase in prehospital time (odds ratio, 1.09 [95% CI, 1.07-1.11]) and after adjustment by 4% (odds ratio, 1.04 [95% CI, 1.01-1.07]). <h3>Conclusions and Relevance</h3> In this study, an increase in total prehospital time was associated with increasing in-hospital all-cause mortality in trauma patients at a physician-staffed emergency medical system, after adjustment for case complexity. Prehospital time is a management objective in analogy to physiological targets. These findings plead for a further streamlining of prehospital trauma care and the need to define the optimal intervention-to-time ratio.
British Medical Association
Authors: C H Reinhold
Journal: BMJ (1904)

The annual meeting of the British Medical Association was held in Edinburgh in the week succeeding the Medico-Psychological meeting. The meeting was one of the most successful that the B.M.A. has ever held, whether as to numbers of members attending or as to the quantity and importance of the matter discussed. Edinburgh possesses many advantages as a place of meeting. The fame of its great medical school is world-wide, and it is full of ardent workers who are determined to maintain and extend its ancient renown as a centre of medical teaching. The social amenity and the accessibility of the northern capital render it specially attractive to the southron.
Circulating dendritic cell as a new prognostic factor in pancreatic cancer patients
Authors: S. Satoi, H. Yanagimoto, S. Takai, H. Toyokawa, K. Takahashi, N. Terakawa, T. Yamamoto, Y. Kamiyama
Journal: Journal of Clinical Oncology (2006)

4095 Background: Pancreatic cancer is a cancer with very poor prognosis that might be associated with impaired immune defense. Dendritic cells (DC) are important for immune surveillance and play a central role in protection against infection and malignancy. A defective host antitumor immune response may allow tumor cells to escape from the host immune system. The aim of this study is to determine whether circulating DC could be one of new immunological markers that may predict the prognosis of the pancreatic cancer. Methods: We evaluated pretreatment circulating myeloid-lineage DC (C-DC1) rate in the peripheral blood mononuclear cell and various clinical parameters to determine their prognostic value in 104 pancreatic cancer patients (41 resected and 63 unresected patients) seen at our institution. Results: In unresected patients, univariate analysis demonstrated two risk factors for prognosis of albmin &lt; 3.8g/dl (p = 0.0468), and C-DC1 &lt; 0.27% (p = 0.0006), when all patients were divided by the median value of C-DC1 rate. Consequently, multivariate analysis demonstrated that only C-DC1 was a predominant independent predictor of survival (Hazard ratio; 9.330, 95% Confidential interval; 2.595–33.549, p = 0.0006). In resected patients, C-DC1 in patients with advanced disease (Stages 2b-4, n=28) was significantly lower than that in patients with lower staged cancer (Stage 1–2a, n = 13: 0.43 ± 0.67%, Stage 2b-4: 0.24 ± 0.30%, p &lt; 0.05). The overall survival rates in patients with C-DC1 ≥ 0.27% were significantly longer than those in patients with C-DC1 &lt; 0.27 (C-DC1 ≥ 0.27%, n = 20, 1/3 year survival: 100%/64%. C-DC1 &lt; 0.27, n = 21, 1/3 year survival: 68%/26%. P &lt; 0.05). Conclusions: The C-DC1 less than 0.27% could be one of prognostic factors in patients with pancreatic cancer, and such patients could be targets for the future therapeutic trials. No significant financial relationships to disclose.
Physician Aid-in-Dying and Suicide Prevention in Psychiatry: A Moral Imperative Over a Crisis
Authors: Bethany C. Calkins, Keith M. Swetz
Journal: The American Journal of Bioethics (2019)

Kious and Battin (2019) posit a moral dilemma created by clinicians not allowing physician aid-in-dying (PAD) for psychiatric suffering, while simultaneously allowing for the involuntary commitment...
TCT-289 Primary Endpoint Results of the World-Wide WIN Registry Assessing a Self-Apposing Stent for Revascularization of Coronary Arteries in Routine Clinical Practice
Authors: Samer Somi, Francesco Amico, Jean-Pascal Peyre, Paolo Sganzerla, Gioel Secco, Giovanni Amoroso, Vi-Phong Huynh
Journal: Journal of the American College of Cardiology (2019)
Single inhaler extrafine triple therapy in uncontrolled asthma (TRIMARAN and TRIGGER): two double-blind, parallel-group, randomised, controlled phase 3 trials
Authors: Johann Christian Virchow, Piotr Kuna, Pierluigi Paggiaro, Alberto Papi, Dave Singh, Sandrine Corre, Florence Zuccaro, Andrea Vele, Maxim Kots, George Georges, Stefano Petruzzelli, Giorgio Walter Canonica
Journal: The Lancet (2019)
Child vaccination rates in England fall across the board, figures show
Authors: Gareth Iacobucci
Journal: BMJ (2019)

Uptake of all 13 routine childhood vaccinations for under 5s has fallen in England over the past year, official statistics show.1

Coverage of the first dose of the measles, mumps, and rubella (MMR) vaccine, as measured among children aged 24 months, decreased for the fifth year in a row—from 91.2% of children in 2017-18 to 90.3% in 2018-19—figures from NHS Digital show. The World Health Organization target is 95%.

MMR coverage rates for the second dose as measured at 5 years decreased from 87.2% to 86.4% last year.

Government and medical leaders raised concerns about the figures.

England’s health secretary, Matt …
TCT-534 Outcomes After Pacemaker Implantation in Patients With New-Onset Left Bundle Branch Block After Transcatheter Aortic Valve Replacement
Authors: Michael Megaly, Mario Goessl, Paul Sorajja, Lucille Anzia, John Henstrom, Pamela Morley, Ross Garberich, Steven Bradley, Chuen Tang, Raed Abdelhadi, Anil Poulose, John Lesser, Santiago Garcia, Jay Sengupta
Journal: Journal of the American College of Cardiology (2019)
TCT-637 Influence of Diabetes on 1-Year Outcome After Revascularization With BioFreedom Stent or Orsiro Stents: A SORT OUT IX Substudy
Authors: Kirstine Hansen, Evald Christiansen, Bent Raungaard, Michael Maeng, Thomas Engstroem, Karsten Veien, Steen Dalby Kristensen, Ole Ahlehoff, Svend Eggert Jensen, Lisette Okkels Jensen
Journal: Journal of the American College of Cardiology (2019)
TCT-683 Variation in the Timing of Percutaneous Coronary Intervention and Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement
Authors: Tomoki Ochiai, Sung-Han Yoon, Nir Flint, Rahul Sharma, Vivek Patel, Tarun Chakravarty, Mamoo Nakamura, Wen Cheng, Raj Makkar
Journal: Journal of the American College of Cardiology (2019)
TCT-393 A "Real-World" Registry of Patients With Left Main Coronary Artery Stent Restenosis: Clinical, Angiographic Characteristics, Therapeutic Management, and Long-Term Follow-Up
Authors: Luis Marcos Lopez Rojas, Santiago Camacho Freire, Jessica Roa-Garrido, Samuel Ortiz Cruces, Rosa Maria Cardenal Piris, Jose Diaz
Journal: Journal of the American College of Cardiology (2019)
TCT-772 Lack of Thrombosis and Other Stitch-Related Complication After Percutaneous Suture-Mediated Closure of Patent Foramen Ovale: A 120,000 Patient-Days Follow Study
Authors: Achille Gaspardone, Gaetano Gioffrè, Emanuela D’Ascoli, Maria Iamele, Fabiana Piccioni, Antonella De Santis, Alessio Stanzione, Maria Benedetta Giannico, Mauro Polzoni, Fabrizio D’Errico, Francesco Summaria, Gregory Sgueglia
Journal: Journal of the American College of Cardiology (2019)
TCT-552 Drug-Coated Balloon Versus Plain Old Balloon Angioplasty in Femoropopliteal Disease: A Meta-Analysis of Randomized Controlled Trials
Authors: Mahesh Anantha Narayanan, Samit Shah, Santiago Garcia, Costin Ionescu, Christopher Regan, Carlos Mena-Hurtado
Journal: Journal of the American College of Cardiology (2019)
Clinical Utility of an Increase in Magnetic Resonance Elastography in Predicting Fibrosis Progression in Nonalcoholic Fatty Liver Disease
Authors: Veeral H. Ajmera, Amy Liu, Seema Singh, Georg Yachoa, Matthew Ramey, Meera Bhargava, Ava Zamani, Scarlett Lopez, Neeraj Mangla, Ricki Bettencourt, Emily Rizo, Mark Valasek, Cynthia Behling, Lisa Richards, Claude Sirlin, Rohit Loomba
Journal: Hepatology (2019)

Cross-sectional studies have shown that magnetic resonance elastography (MRE) is accurate in the noninvasive detection of advanced fibrosis in nonalcoholic fatty liver disease (NAFLD). However, there are limited data on the longitudinal association between an increase in liver stiffness on MRE and fibrosis progression in NAFLD. Therefore, using a well-characterized prospective cohort of patients with biopsy-proven NAFLD, we aimed to examine the longitudinal association between a 15% increase in liver stiffness on MRE and fibrosis progression in NAFLD.This prospective cohort study included 102 patients (62.7% women) with biopsy-proven NAFLD who underwent contemporaneous MRE and liver biopsy at baseline followed by a repeat paired liver biopsy and MRE assessment. The primary outcome was odds of fibrosis progression by one or more stage as assessed by the Nonalcoholic Steatohepatitis Clinical Research Network histologic scoring system. The mean (±SD) of age and body mass index (BMI) were 52 (±14) years and 32.6 (±5.3) kg/m2 , respectively. The median time interval between the two paired assessments was 1.4 years (interquartile range 2.15 years). The number of patients with fibrosis stages 0, 1, 2, 3, and 4 was 27, 36, 12, 17, and 10, respectively. In unadjusted analysis, a 15% increase in MRE was associated with increased odds of histologic fibrosis progression (odds ratio [OR], 3.56; 95% confidence interval [CI], 1.17-10.76; P = 0.0248). These findings remained clinically and statistically significant even after multivariable adjustment for age, sex, and BMI (adjusted OR, 3.36; 95% CI, 1.10-10.31; P = 0.0339). A 15% increase in MRE was the strongest predictor of progression to advanced fibrosis (OR, 4.90; 95% CI, 1.35-17.84; P = 0.0159).A 15% increase in liver stiffness on MRE may be associated with histologic fibrosis progression and progression from early fibrosis to advanced fibrosis.
Hyperpolarized MRI of Human Prostate Cancer Reveals Increased Lactate with Tumor Grade Driven by Monocarboxylate Transporter 1
Authors: Kristin L. Granlund, Sui-Seng Tee, Hebert A. Vargas, Serge K. Lyashchenko, Ed Reznik, Samson Fine, Vincent Laudone, James A. Eastham, Karim A. Touijer, Victor E. Reuter, Mithat Gonen, Ramon E. Sosa, Duane Nicholson, YanWei W. Guo, Albert P. Chen, James Tropp, Fraser Robb, Hedvig Hricak, Kayvan R. Keshari
Journal: Cell Metabolism (2019)
TCT-430 Comparison of Tricuspid Annulus Measurements by 2D Transthoracic and Transesophageal Echocardiography, and 3D Automated Transesophageal Echocardiography With CT Annulus Measurements in Patients With Severe Tricuspid Regurgitation Being Evaluated for Transcatheter Intervention
Authors: Shawn Reginauld, Shizhen Liu, Sara Mobasseri, Hassan Sayegh, Vivek Rajagopal, Christopher Meduri, Mani Vannan
Journal: Journal of the American College of Cardiology (2019)
Association of Frailty With 30-Day Outcomes for Acute Myocardial Infarction, Heart Failure, and Pneumonia Among Elderly Adults
Authors: Harun Kundi, Rishi K. Wadhera, Jordan B. Strom, Linda R. Valsdottir, Changyu Shen, Dhruv S. Kazi, Robert W. Yeh
Journal: JAMA Cardiology (2019)

The addition of a claims-based frailty metric to traditional comorbidity-based risk-adjustment models for acute myocardial infarction (AMI), heart failure (HF), and pneumonia improves the prediction of 30-day mortality and readmission. This may have important implications for hospitals that tend to care for frail populations and participate in Centers for Medicare & Medicaid Services value-based payment programs, which use these risk-adjusted metrics to determine reimbursement.To determine whether the addition of frailty measures to traditional comorbidity-based risk-adjustment models improved prediction of outcomes for patients with AMI, HF, and pneumonia.A nationwide cohort study included Medicare fee-for-service beneficiaries 65 years and older in the United States between January 1 and December 1, 2016. Analysis began August 2018.Rates of mortality within 30 days of admission and 30 days of discharge, as well as 30-day readmission rates by frailty group. We evaluated the incremental effect of adding the Hospital Frailty Risk Score (HFRS) to current comorbidity-based risk-adjustment models for 30-day outcomes across all conditions.For 785 127 participants, there were 166 200 hospitalizations [21.2%] for AMI, 348 619 [44.4%] for HF, and 270 308 [34.4%] for pneumonia. The mean (SD) age at the time of hospitalization was 79.2 (8.9) years; 656 315 (83.6%) were white and 402 639 (51.3%) were women. The mean (SD) HFRS was 7.3 (7.4) for patients with AMI, 10.8 (8.3) for patients with HF, and 8.2 (5.7) for patients with pneumonia. Among patients hospitalized for AMI, an HFRS more than 15 (compared with an HFRS <5) was associated with a higher risk of 30-day postadmission mortality (adjusted odds ratio [aOR], 3.6; 95% CI, 3.4-3.8), 30-day postdischarge mortality (aOR, 4.0; 95% CI, 3.7-4.3), and 30-day readmission (aOR, 3.0; 95% CI, 2.9-3.1) after multivariable adjustment for age, sex, race, and comorbidities. Similar patterns were observed for patients hospitalized with HF (30-day postadmission mortality: aOR, 3.5; 95% CI, 3.4-3.7; 30-day postdischarge mortality: aOR, 3.5; 95% CI, 3.3-3.6; and 30-day readmission: aOR, 2.9; 95% CI, 2.8-3.0) and among patients with pneumonia (30-day postadmission mortality: aOR, 2.5; 95% CI, 2.3-2.6; 30-day postdischarge mortality: aOR, 3.0; 95% CI, 2.9-3.2; and 30-day readmission: aOR, 2.8; 95% CI, 2.7-2.9). The addition of HFRS to traditional comorbidity-based risk-prediction models improved discrimination to predict outcomes for all 3 conditions.Among Medicare fee-for-service beneficiaries, frailty as measured by the HFRS was associated with mortality and readmissions among patients hospitalized for AMI, HF, or pneumonia. The addition of HFRS to traditional comorbidity-based risk-prediction models improved the prediction of outcomes for all 3 conditions.
Studies on an Attenuated Measles-Virus Vaccine
Authors: Francis L. Black, Sylvester R. Sheridan
Journal: New England Journal of Medicine (1960)

IN initial trials, the attenuated measles vaccine was given by subcutaneous injection, but the intact mucous membranes have certain practical and theoretical advantages to recommend them as a route of vaccination. In this study tests were carried out to compare the effectiveness of the subcutaneous route with other routes that might be involved in natural transmission of the disease. The object was to determine the infectivity of attenuated measles virus by naturally available routes both as a potential method of immunization and as a measure of the capacity of the virus to infect contacts of those vaccinated.On the basis . . .