Blood Culture Results Before and After Antimicrobial Administration
Authors: Michiel Schinkel, Rishi Nannan Panday, Prabath Nanayakkara
Journal: Annals of Internal Medicine (2020)

Letters17 March 2020Blood Culture Results Before and After Antimicrobial AdministrationMichiel Schinkel, MD, Rishi Nannan Panday, MD, PhD, and Prabath Nanayakkara, MD, PhDMichiel Schinkel, MDCenter of Experimental and Molecular Medicine, Amsterdam UMC, Academic Medical Center, and Amsterdam UMC, VU University Medical Center, Amsterdam, the Netherlands (M.S.)Search for more papers by this author, Rishi Nannan Panday, MD, PhDAmsterdam UMC, VU University Medical Center, Amsterdam, the Netherlands (R.N.P., P.N.)Search for more papers by this author, and Prabath Nanayakkara, MD, PhDAmsterdam UMC, VU University Medical Center, Amsterdam, the Netherlands (R.N.P., P.N.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L19-0794 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read Cheng and colleagues' article (1) on blood culture results before and after initiation of antimicrobial therapy in severely ill patients with sepsis with interest. The question of whether empirical therapy reduces the sensitivity of blood cultures is inseparable from the ongoing debate on the proposed benefits of early administration of antibiotics for sepsis. The assumption that early administration is beneficial has come under scrutiny lately. The PHANTASi (Prehospital Antibiotics Against Sepsis) trial coordinated by our group did not show a mortality benefit of early antibiotics for a general population with sepsis (2). If a benefit ...References1. Cheng MP, Stenstrom R, Paquette K, et al; FABLED Investigators. Blood culture results before and after antimicrobial administration in patients with severe manifestations of sepsis. A diagnostic study. Ann Intern Med. 2019;171:547-54. [PMID: 31525774]. doi:10.7326/M19-1696 LinkGoogle Scholar2. Alam N, Oskam E, Stassen PM, et al; PHANTASi Trial Investigators and the ORCA (Onderzoeks Consortium Acute Geneeskunde) Research Consortium the Netherlands. Prehospital antibiotics in the ambulance for sepsis: a multicentre, open label, randomised trial. Lancet Respir Med. 2018;6:40-50. [PMID: 29196046] doi:10.1016/S2213-2600(17)30469-1 CrossrefMedlineGoogle Scholar3. Seymour CW, Gesten F, Prescott HC, et al. Time to treatment and mortality during mandated emergency care for sepsis. N Engl J Med. 2017;376:2235-44. [PMID: 28528569] doi:10.1056/NEJMoa1703058 CrossrefMedlineGoogle Scholar4. Mi MY, Klompas M, Evans L. Early administration of antibiotics for suspected sepsis. N Engl J Med. 2019;380:593-6. [PMID: 30726686] doi:10.1056/NEJMclde1809210 CrossrefMedlineGoogle Scholar5. Ippolito MM, Johnson J, Mullin C, et al. The relative effects of artemether-lumefantrine and non-artemisinin antimalarials on gametocyte carriage and transmission of Plasmodium falciparum: a systematic review and meta-analysis. Clin Infect Dis. 2017;65:486-94. [PMID: 28402391] doi:10.1093/cid/cix336 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Center of Experimental and Molecular Medicine, Amsterdam UMC, Academic Medical Center, and Amsterdam UMC, VU University Medical Center, Amsterdam, the Netherlands (M.S.)Amsterdam UMC, VU University Medical Center, Amsterdam, the Netherlands (R.N.P., P.N.)Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L19-0794. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoBlood Culture Results Before and After Antimicrobial Administration in Patients With Severe Manifestations of Sepsis Matthew P. Cheng , Robert Stenstrom , Katryn Paquette , Sarah N. Stabler , Murtaza Akhter , Adam C. Davidson , Marko Gavric , Alexander Lawandi , Rehman Jinah , Zahid Saeed , Koray Demir , Kelly Huang , Amirali Mahpour , Chris Shamatutu , Chelsea Caya , Jean-Marc Troquet , Greg Clark , Cedric P. Yansouni , David Sweet , and Blood Culture Results Before and After Antimicrobial Administration Larry M. Bush and Donald Kaye Blood Culture Results Before and After Antimicrobial Administration Matthew P. Cheng , Robert Stenstrom , Katryn Paquette , Cedric Yansouni , and David Sweet Blood Culture Results Before and After Antimicrobial Administration Shinya Yamamoto and Koh Okamoto Metrics 17 March 2020Volume 172, Issue 6Page: 439KeywordsAntibiotic resistanceAntibioticsAntimicrobialsBloodConflicts of interestDisclosureEmergency departmentMortalitySepsisShock ePublished: 17 March 2020 Issue Published: 17 March 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...