tbuckley/cabot-search huggingface dataset:
Real‐world data for direct stage‐specific costs of melanoma healthcare
Authors: A. Buja, M. Rivera, A. De Polo, M. Zorzi, E. Carpin, A. Vecchiato, P. Del Fiore, G. Martin, M. Saia, V. Baldo, M. Rugge, C.R. Rossi
Journal: British Journal of Dermatology (2020)
Considering gut microbiota in treatment of type 2 diabetes mellitus
Authors: Aneseh Adeshirlarijaney, Andrew T. Gewirtz
Journal: Gut Microbes (2020)

Advances in the understanding of the pathogenesis of type 2 diabetes mellitus (T2D) have revealed a role for gut microbiota dysbiosis in driving this disease. This suggests the possibility that approaches to restore a healthy host–microbiota relationship might be a means of ameliorating T2D. Indeed, recent studies indicate that many currently used treatments for T2D are reported to impact gut microbiota composition. Such changes in gut microbiota may mediate and/or reflect the efficacy of these interventions. This article outlines the rationale for considering the microbiota as a central determent of development of T2D and, moreover, reviews evidence that impacting microbiota might be germane to amelioration of T2D, both in terms of understanding mechanisms that mediate efficacy of exiting T2D therapies and in developing novel treatments for this disorder.
When Low Rates of Bullying Increase Risks for Those Who Are Bullied
Authors: Jaana Juvonen, Hannah L. Schacter
Journal: JAMA Pediatrics (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Inadequate Physical Activity and Sedentary Behavior Are Independent Predictors of Nonalcoholic Fatty Liver Disease
Authors: Donghee Kim, Luis Miguel Vazquez‐Montesino, Andrew A. Li, George Cholankeril, Aijaz Ahmed
Journal: Hepatology (2020)

Background and Aims In general, physical activity (PA) and nonalcoholic fatty liver disease (NAFLD) have an inverse association. However, studies assessing the impact of the widely accepted Physical Activity Guidelines for Americans ( PA Guidelines ) on NAFLD are lacking. Approach and Results We performed a serial, cross‐sectional analysis among adults by using the 2007‐2016 US National Health and Nutrition Examination Survey. NAFLD and advanced fibrosis were defined by using various noninvasive panels. A PA questionnaire assessed the leisure‐time PA, occupation‐related PA, transportation‐related PA, and total sitting time as sedentary behavior. PA was categorized according to the PA Guidelines . Of the 24,588 individuals (mean age, 47.4 years; 47.9% males), leisure‐time PA (≥150 minutes per week) demonstrated 40% lower odds of NAFLD, whereas transportation‐related PA was associated with a 33% risk reduction in NAFLD. Analysis of total PA and sitting times simultaneously showed a dose‐response association between sitting time and NAFLD ( P for trend &lt; 0.001). Compliance with the PA Guidelines was lower in individuals with NAFLD versus those without NAFLD. The trends in compliance with the PA Guidelines for any type of PA remained stable in individuals with NAFLD except for a downtrend in transportation‐related PA. In contrast, an improvement in compliance with the PA Guidelines for leisure time was noted in the cohort without NAFLD. Although PA demonstrated a 10% stronger association with risk reduction of NAFLD in women, women showed a lower tendency of meeting the PA Guidelines . Trends in total sitting time increased significantly regardless of NAFLD status. Conclusions Sedentary behavior emerged as an independent predictor of NAFLD. Overall compliance with the PA Guidelines was lower in the cohort with NAFLD, with sex‐ and ethnicity‐based differences. Implementation of these observations in clinical practice may improve our understanding as well as clinical outcomes.
Endoscopic and percutaneous ultrasound-guided thrombin and glue injection in a pseudoaneurysm of the right hepatic artery
Authors: Ashlee Sidhu, Nagoor Basha Shaik, Malay Sharma
Journal: Endoscopy (2020)

Laparoscopic cholecystectomy is complicated by bile duct injuries in 0.6 % – 0.8 % of cases [1]. The injury is categorized as complex if it is located above the confluence or if it is associated with vascular injury. Isolated vascular injuries, such as hepatic artery pseudoaneurysms (HAPs), after laparoscopic cholecystectomy are rare, but may occur in 25 % of patients who suffer bile duct injuries [2]. HAPs have a clinically unpredictable course with varied presentation [3]. We present a case of complex bile duct injury that presented as obstructive jaundice and hemobilia due to a pseudoaneurysm of the hepatic artery after laparoscopic cholecystectomy.
αIIb-Integrin (CD41) associated with blood eosinophils is a potential biomarker for disease activity in eosinophilic esophagitis
Authors: Mats W. Johansson, Elizabeth M. McKernan, Paul S. Fichtinger, Evelyn L. Angulo, Jennifer L. Bagley, Kristine E. Lee, Michael D. Evans, Luis D. Lomeli, Deane F. Mosher, Shelly M. Cook, Eric A. Gaumnitz, Sameer K. Mathur
Journal: Journal of Allergy and Clinical Immunology (2020)
Awareness of Cancer Screening During the Treatment of Renal Failure Patients: Physician Questionnaire
Authors: O. Uysal Sonmez, U. Uyeturk, I.I. Budakoglu, R. Kazancioglu, I. Turker, B. Budakoglu, U. Yalcintas Arslan, O.B. Oksuzoglu
Journal: Annals of Oncology (2012)
Bowel obstruction: inquiry finds significant delays in care pathway
Authors: Jacqui Wise
Journal: BMJ (2020)

Patients with acute bowel obstruction are experiencing significant delays at every stage in the care pathway, contributing to the high mortality rates for the condition, a report by the National Confidential Enquiry into Patient Outcome and Death has concluded.1

There are over 22 000 admissions for bowel obstruction in England and Wales each year, of which 6.4% result in death within 90 days. When surgery is required, mortality can exceed 10%, far higher than seen in elective gastrointestinal surgery.

The report says there are significant opportunities to improve patient care for those …
Variant Interpretation in Patients With Metastatic Breast Cancer—Reply
Authors: Sarah Croessmann, Ben Ho Park
Journal: JAMA Oncology (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
RT-PCR based tyrosine kinase display profiling of canine melanoma: IGF-1 receptor as a potential therapeutic target
Authors: Michael K. Huelsmeyer, Ann M. Mitzey, Tracy Baker, Megan Swaab, Douglas H. Thamm
Journal: Cancer Research (2005)

1115  Introduction: Metastatic melanoma can be a devastating disease, and the optimal nonsurgical treatment remains unknown. Canine mucosal melanoma (CMM) resembles human melanoma in terms of metastatic behavior, refractoriness to standard therapy, and tumor antigen expression but it is not known how closely CMM resembles human melanoma with regard to molecular pathogenesis. There is a wealth of information available regarding tyrosine kinase (TK) expression in human cancer, however no attempt has been made to systematically define the repertoire of TKs expressed in CMM. This study employed a molecular technique called RT-PCR display to simultaneously evaluate the expression of up to 30 different TKs in a CMM cell line. Materials and Methods: mRNA was extracted and reverse-transcribed from the 17CM98 CMM cell line, then subjected to PCR using degenerate primers coding for highly conserved regions flanking the kinase domains of many receptor and nonreceptor TKs. The resulting 210-bp product was ligated into pCR-Topo2.1 and used to transform E. coli. Multiple bacterial colonies were isolated, the cDNA inserts sequenced and then compared with published sequence data using BLASTn. Results and Conclusions: Sequencing 46 clones yielded canine homologs of IGF-1R (50%), JAK1 (17%), PDGFR-a (11%), FGFR1 (9%), Axl (7%), c-Abl (4%), and PTK2 (2%). Interestingly, IGF-1R, JAK1 and Axl were detected using a similar technique in human melanoma, supporting the cross-species validity of this assay. Given the relative abundance of IGF-1R clones, we sought to determine the biologic effect of rhIGF-1 in 17CM98 cells. IGF-1 stimulated IGF-1R phosphorylation, cell proliferation and VEGF production in 17CM98, and protected the cells from serum starvation-induced apoptosis. Addition of the IGF-1R kinase inhibitor ADW742 (Novartis) abrogated all IGF-1 induced changes. Expression of IGF-1R mRNA was detected in 5 of 5 additional CMM cell lines evaluated, suggesting that IGF-1R expression may be common in CMM cells and providing a novel target for future therapy. In conclusion, this study demonstrates the applicability of the tyrosine kinase RT-PCR display technique to canine cells, suggests that a similar spectrum of TKs are expressed by human and canine melanoma, and demonstrates the efficacy of ADW742 in IGF-1R expressing canine tumor cells.
Risk and Response Adapted Treatment Guidelines for Managing First Relapsed and Refractory Classical Hodgkin Lymphoma in Children and Young People. Recommendations from the EuroNet Pediatric Hodgkin Lymphoma Group
Authors: Stephen Daw, Dirk Hasenclever, Maurizio Mascarin, Ana Fernández‐Teijeiro, Walentyna Balwierz, Auke Beishuizen, Roberta Burnelli, Michaela Cepelova, Alexander Claviez, Karin Dieckmann, Judith Landman‐Parker, Regine Kluge, Dieter Körholz, Christine Mauz‐Körholz, William Hamish Wallace, Thierry Leblanc
Journal: HemaSphere (2020)

The objective of this guideline is to aid clinicians in making individual salvage treatment plans for pediatric and adolescent patients with first relapse or refractory (R/R) classical Hodgkin lymphoma (cHL). While salvage with standard dose chemotherapy followed by high dose chemotherapy and autologous stem cell transplant is often considered the standard of care in adult practice, pediatric practice adopts a more individualized risk stratified and response adapted approach to salvage treatment with greater use of non-transplant salvage. Here, we present on behalf of the EuroNet Pediatric Hodgkin Lymphoma group, evidence and consensus-based guidelines for standardized diagnostic, prognostic and response procedures to allocate children and adolescents with R/R cHL to stratified salvage treatments.
Active Specific Immunotherapy with Racotumomab in the Treatment of Advanced
Authors: A. Macías, S. Alfonso, E. Santiesteban, C. Viada, I. Mendoza, P.P. Guerra, R.E. Gómez, M.L. Ardigo, A.M. Vázquez, R. Pérez
Journal: Annals of Oncology (2012)
Abstract 13415: Predictive Value of Glomerular Filtration Rate-Adjusted Contrast Volume for Contrast-Induced Acute Kidney Injury After Percutaneous Coronary Intervention
Authors: Haruo Nakamura, Kenichiro Otsuka, Tomohiro Yamaguchi, Hirotoshi Ishikawa, Hisashi Katayama, Hisateru Takeda, Kohei Fujimoto, Minoru Yoshiyama, Noriaki Kasayuki
Journal: Circulation (2015)

Introduction: Contrast volume (CV) to estimated glomerular filtration rate (eGFR) ratio has been known as a useful predictor of contrast-induced acute kidney injury (CI-AKI) after percutaneous coronary intervention (PCI). However, a cutoff value of CV/eGFR has not been established. Hypothesis: We investigated the clinical predictors and predictive value of CV/eGFR for CI-AKI in patients with coronary artery disease (CAD) underwent PCI. Methods: This study consists of 479 hemodynamically stable CAD patients (mean age: 73±10 years) underwent PCI. Patients, and target lesion characteristics were obtained. The primary endpoint was the occurrence of CI-AKI defined as an increase in serum creatinine of 0.5 mg/dl or 25 % within 48 hours after contrast injection. Logistic regression analysis was used to estimate the association of clinical risk factors with development of CI-AKI. Receiver-operating characteristic curve (ROC) analysis was performed to determine the predictive value of CV/eGFR for CI-AKI. Results: Mean procedural CV was 93±38 ml. CI-AKI was occurred in 19 patients (3.9%). Multivariate logistic regression analysis showed that higher CV/eGFR (odds ratio; 1.8, 95% confidence interval; 1.03-2.98; p=0.03) was a statistically significant predictor of CI-AKI independent other risk factors (Table). Using ROC analysis for prediction of CI-AKI, the area under the curve was 0.67, and the best cutoff value of CV/eGFR was 1.64 (sensitivity was 8.0%, specificity was 98%, positive and negative predictive values were 58% and 73%, respectively). Conclusions: The results of this study suggest that high CV/eGFR is a predictive marker for CI-AKI after PCI independent of other clinical risk factors. Reducing a CV less than 1.64 of eGFR might be valuable in preventing CI-AKI after PCI.
Therapy for Stage IV Non–Small-Cell Lung Cancer Without Driver Alterations: ASCO and OH (CCO) Joint Guideline Update
Authors: Nasser H. Hanna, Bryan J. Schneider, Sarah Temin, Sherman Baker, Julie Brahmer, Peter M. Ellis, Laurie E. Gaspar, Rami Y. Haddad, Paul J. Hesketh, Dharamvir Jain, Ishmael Jaiyesimi, David H. Johnson, Natasha B. Leighl, Tanyanika Phillips, Gregory J. Riely, Andrew G. Robinson, Rafael Rosell, Joan H. Schiller, Navneet Singh, David R. Spigel, Janis O. Stabler, Joan Tashbar, Gregory Masters
Journal: Journal of Clinical Oncology (2020)

PURPOSE The aim of this work is to provide evidence-based recommendations updating the 2017 ASCO guideline on systemic therapy for patients with stage IV non–small-cell lung cancer (NSCLC) without driver alterations. A guideline update for patients with stage IV NSCLC with driver alterations will be published separately. METHODS The American Society of Clinical Oncology and Ontario Health (Cancer Care Ontario) NSCLC Expert Panel made updated recommendations based on a systematic review of randomized controlled trials from December 2015 to 2019. RESULTS This guideline update reflects changes in evidence since the previous guideline update. Five randomized controlled trials provide the evidence base. Additional literature suggested by the Expert Panel is discussed. RECOMMENDATIONS Recommendations apply to patients without driver alterations in epidermal growth factor receptor or ALK. For patients with high programmed death ligand 1 (PD-L1) expression (tumor proportion score [TPS] ≥ 50%) and non–squamous cell carcinoma (non-SCC), the Expert Panel recommends single-agent pembrolizumab. Additional treatment options include pembrolizumab/carboplatin/pemetrexed, atezolizumab/carboplatin/paclitaxel/bevacizumab, or atezolizumab/carboplatin/nab-paclitaxel. For most patients with non-SCC and either negative (0%) or low positive (1% to 49%) PD-L1, the Expert Panel recommends pembrolizumab/carboplatin/pemetrexed. Additional options are atezolizumab/carboplatin/nab-paclitaxel, atezolizumab/carboplatin/paclitaxel/bevacizumab, platinum-based two-drug combination chemotherapy, or non–platinum-based two-drug therapy. Single-agent pembrolizumab is an option for low positive PD-L1. For patients with high PD-L1 expression (TPS ≥ 50%) and SCC, the Expert Panel recommends single-agent pembrolizumab. An additional treatment option is pembrolizumab/carboplatin/(paclitaxel or nab-paclitaxel). For most patients with SCC and either negative (0%) or low positive PD-L1 (TPS 1% to 49%), the Expert Panel recommends pembrolizumab/carboplatin/(paclitaxel or nab-paclitaxel) or chemotherapy. Single-agent pembrolizumab is an option in select cases of low positive PD-L1. Recommendations are conditional on the basis of histology, PD-L1 status, and/or the presence or absence of contraindications. Additional information is available at www.asco.org/lung-cancer-guidelines .
How to Best Detect Portal Vein Tumor Thrombosis in Patients with Hepatocellular Carcinoma Meeting the Milan Criteria: Gadoxetic Acid-Enhanced MRI versus Contrast-Enhanced CT
Authors: Jae Seok Bae, Jeong Min Lee, Jeong Hee Yoon, Siwon Jang, Jin Wook Chung, Kyung Bun Lee, Nam-Joon Yi, Jeong-Hoon Lee
Journal: Liver Cancer (2020)

The detection of portal vein tumor thrombosis (PVTT) in patients with hepatocellular carcinoma (HCC) meeting the Milan criteria is of critical importance as PVTT is known to be a contraindication to transplantation and an indicator of a dismal prognosis.To determine which modality may best detect PVTT, we compared the diagnostic performance of gadoxetic acid-enhanced MRI (GA-MRI) and contrast-enhanced CT (CECT) in HCC patients meeting the Milan criteria.We retrospectively enrolled 310 patients with HCCs meeting the Milan criteria who underwent both GA-MRI and CECT between June 2007 and May 2017. Among them, 44 patients were demonstrated to have PVTT while 266 patients had no PVTT. Two radiologists then assessed GA-MRI and CECT images for the presence of PVTT on a 5-point scale as well as vessel expansion, continuity with tumors, and enhancement on both modalities, as well as T2 hyperintensity and diffusion restriction on GA-MRI. The McNemar test was used to compare sensitivity and specificity of GA-MRI and CECT for the detection of PVTT, and Fisher's exact test was used to compare their imaging features.GA-MRI showed higher sensitivity values than CECT in detecting PVTT (reviewer 1, 93.2% [41/44] vs. 77.3% [34/44]; reviewer 2, 88.6% [39/44] vs. 70.5% [31/44]) (both p = 0.039). Specificity of GA-MRI and CECT demonstrated no difference (reviewer 1, 95.5% [254/266] vs. 95.1% [253/266]; reviewer 2, 97.0% [258/266] vs. 97.4% [259/266]) (both p > 0.999). Continuity with tumors and enhancement were more frequently observed on GA-MRI than on CECT (p < 0.050, both reviewers).GA-MRI detected PVTT more often than CECT in HCC patients meeting the Milan criteria and better depicted PVTT in continuity with tumors and those showing enhancement than CECT.
Altering Sphingolipid Metabolism Attenuates Cell Death and Inflammatory Response After Myocardial Infarction
Authors: Yoav Hadas, Adam S. Vincek, Elias Youssef, Magdalena M. Żak, Elena Chepurko, Nishat Sultana, Mohammad Tofael Kabir Sharkar, Ningning Guo, Rinat Komargodski, Ann Anu Kurian, Keerat Kaur, Ajit Magadum, Anthony Fargnoli, Michael G. Katz, Nadia Hossain, Ephraim Kenigsberg, Nicole C. Dubois, Eric Schadt, Roger Hajjar, Efrat Eliyahu, Lior Zangi
Journal: Circulation (2020)

Sphingolipids have recently emerged as a biomarker of recurrence and mortality after myocardial infarction (MI). The increased ceramide levels in mammalian heart tissues during acute MI, as demonstrated by several groups, is associated with higher cell death rates in the left ventricle and deteriorated cardiac function. Ceramidase, the only enzyme known to hydrolyze proapoptotic ceramide, generates sphingosine, which is then phosphorylated by sphingosine kinase to produce the prosurvival molecule sphingosine-1-phosphate. We hypothesized that Acid Ceramidase (AC) overexpression would counteract the negative effects of elevated ceramide and promote cell survival, thereby providing cardioprotection after MI.
Phase I/II study of carfilzomib, bendamustine, and dexamethasone (CBD) in patients with newly diagnosed multiple myeloma
Authors: Siyang Leng, Divaya Bhutani, Shahzad Raza, Amer Assal, Samuel Pan, Jianhua Hu, Alexander Wei, Markus Mapara, Suzanne Lentzsch
Journal: Blood Cancer Journal (2020)
Abstract 15393: Physical Activity, Chronic Myocardial Injury and Risk of Heart Failure in African Americans: The Jackson Heart Study
Authors: Shawn Simek, Ambarish Pandey, Colby Ayers, Ian Neeland, Christopher DeFilippi, Alana A Lewis, Robert Mentz, Adolfo Correa, Wondwosen Yimer, Michael Hall, Carlos Rodriguez, James de Lemos, Jarett Berry
Journal: Circulation (2018)

Introduction: Physical inactivity and chronic myocardial injury, defined by elevation in high sensitivity cardiac troponin (Hs-Tn) levels, are important risk factors for HF in African Americans (AA...
Ongoing mumps outbreak among adolescents and young adults, Ireland, August 2018 to January 2020
Authors: Annamaria Ferenczi, Sarah Gee, Suzanne Cotter, Kevin Kelleher
Journal: Eurosurveillance (2020)

Between 18 August 2018 and 24 January 2020, 3,736 mumps cases were notified in Ireland. The highest numbers of notifications were observed in the age group 15-24 years. Vaccination status was reported for 32% (n = 1,199) of cases: 72% of these had received two doses of measles-mumps-rubella (MMR) vaccine. Vaccination uptake after free MMR vaccination targeting colleges and universities since early 2019 was low. Therefore, a national media campaign began in January 2020.