tbuckley/cabot-search huggingface dataset:
Age as a prognostic factor in osteosarcoma: Survival analysis.
Authors: Maria Pallotta Guadalupe, Gaston Federico Boggio, Sergio Specterman, Jose Maria Lastiri, Maria Emilia Lopez Lincuez, Lorena Lupinacci, Monica Makiya, Patricia Streitenberger, Luis Aponte, German Farfalli, MIguel Angel Ayerza
Journal: Journal of Clinical Oncology (2012)

10074 Background: Studies comparing survival between adult and paediatric population with osteosarcoma are scarce and contradictory. Generally adults were excluded from analysis in historical series. End Point: evaluate age as prognostic factor in ostosarcomas IIb treated exclusively by a multidisciplinary group in a single institution. Methods: 132/278 patients with histological diagnosis of osteosarcoma IIb were selected. All were treated exclusively in our hospital from July 1988 until December 2010. Patients 17 years old or younger were considered paediatric. They all received presurgical chemotherapy with the same scheme: ifosfamide + doxorrubicin + high dose methotrexate. Univariate analysis was made (Fischer exact test). Survival was calculated wih Kaplan-Meier actuarial method. Curves were compared with log rank test. Multivariate Cox analysis was made. Results: Median age was 19.6 years (std: 9,1; range 5-58). Adults: 77, children: 55. No differences were detected between the two age groups regarding: elevated alkaline phosphatase, kind of surgery (amputation vs. limb sparing), relapse site (lung, local, other), necrosis greater than 90% or number of lung resections. There was a tendency towards axial localization in adults (p=0.05). No paediatric patient had inadequate medical intervention, but it was present in 14.3% of adults (p=0.002). 5 year Overall survival (5y OS) in children was 85,2% compared with 61,8% in adults (p=0.005); Disease free survival (DFS) had a non significant tendency to be better in children (69.6% vs. 51,3%). Variables associated with worse OS were: axial location (p=0.01), elevated alkaline phosphatase (0.003), amputation (p=0.008), local relapse or systemic non-lung metastasis (p= 0.001), necrosis less than 90% (0.001). Multivariate Cox analysis showed association between OS and paediatric population (p=0.01) and necrosis greater than 90% (p=0.001), while DFS was associated with necrosis greater than 90% (p=0.01) and elevated alkaline phosphatase (p=0.05). Conclusions: Paediatric population presents better survival compared to adults in our institution. Differences in tumour biology and in the mode of presentation related to age may be the explanation.
SUBCLAVIAN AND AXILLARY VEIN ACCESS VS CEPHALIC VEIN CUT-DOWN FOR LEAD IMPLANTATION: A META-ANALYSIS
Authors: Varunsiri Atti, Mohit Turagam, Aakash Angirekula, Shannon Heffer, Jalaj Garg, Pradeep Kumar Devarakonda, Scott Koerber, Andrea Natale, Dhanunjaya R. Lakkireddy
Journal: Journal of the American College of Cardiology (2020)
EXTENDED DURATION ANTICOAGULATION WITH DIRECT ORAL ANTICOAGULANTS FOR UNPROVOKED VENOUS THROMBOEMBOLISM TO PREVENT RECURRENT VENOUS THROMBOEMBOLISM EVENTS: A META-ANALYSIS OF RANDOMIZED TRIALS
Authors: Madhan Shanmugasundaram, Ghulam Murtaza, Faisal Khalid, Sundeep Shenoy, Timir K. Paul
Journal: Journal of the American College of Cardiology (2020)
NOVEL APPROACH COMBINING MACHINE LEARNING AND SYSTEM DYNAMICS MODELING FOR PREDICTION OF RISK OF SECONDARY CARDIOVASCULAR EVENTS AND EFFECT OF INTERVENTIONS
Authors: Fang He, John Page, Narendra Patil, Jesisca Tandi, Abhijit Ghosh, Christian Liman, Joydeep Sarkar, E Shyong Tai, Khung Yeo
Journal: Journal of the American College of Cardiology (2020)
Limited Clinical Application and Concerns of Bias in Long-term Risk of Epilepsy, Psychiatric Disorders, and Mortality Following Febrile Seizures
Authors: Helen Puusepp-Benazzouz, Habibur Rehman Bhurawala
Journal: JAMA Pediatrics (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
A retrospective evaluation of locally advanced thymoma and thymic carcinoma: Factors influencing the prognosis after local treatment modalities.
Authors: Ülkü Yalçintas Arslan, Caglayan Geredeli, Nuriye Özdemir, Aydin Ciltas, Ozlem Sonmez, Mehmet Kucukoner, Halit Karaca, Ayse Gok Durnali, Melih Cem Boruban, Nurullah Zengin, Suleyman Buyukberber, Ali Suner, Mesut Seker, Necati Alkis, Omur Berna Oksuzoglu
Journal: Journal of Clinical Oncology (2013)

e18510 Background: Aim of the study was to determine the relationship between clinicopathologic characteristics and treatment modalities for locally advanced thymic malignancies(TM). Methods: We retrospectively reviewed medical records of 107 patients(pts) who treated from 1992 to 2012 in medical oncology service of 7 tertiary hospital. 21 pts who presented metastatic disease and 31 pts who had early stage at the time of diagnosis were excluded. Results: A total of 55 patient’s data were analyzed. Median age was 46(17-73) years. Median follow-up was 33(1-103) months(mts). 65% of pts was male. Histopathologic diagnosis were as follows: thymoma type A-B2 ( TA-B2) 29 , thymoma type B3 (TB3) 10 and thymic carcinoma (TC) 16. 42 of pts underwent surgery, but total resection of the tumor have been achieved at only 28 pts(6 TC and 22 TA-B2 or TB3).30 pts have stage III diasease (mostly thymoma 23/30). 43 pts treated with mediastinal radiotherapy ( 21 adjuvant, 22 primary). A cisplatin containing regimen has been received 23 pts in the adjuvant setting. 31 pts were given as primary chemotherapy (ADOC, PAC and EP). Overall response rate was 81.6% with first-line chemotherapy. There was no apparent response in 3 pts(3/23) with thymoma and 4 pts(4/8) with TC. 20 pts have experienced a disease progression and 27 pts died ( 8 of these cases died from other unrelated causes). Median progression free survival was 45 (30-59)mts. Kaplan-Meier survival analysis estimated that overall survival of the pts with stage III disease were relatively longer than stage IVA ones, but it can not reach statistical significance (median 78 vs 45 mts,p=.11). Prognosis of TC pts were considerably worse than TB3 and TA-B2 (median 17 vs 45 vs 76 mts respectively,p=.01). Although there was no a statistical difference between pts who underwent total tumor removal and who did not, we have seen a trend toward better survival in pts who were suitable to triple modality therapy(median 79 vs 45 mts,p=.27). Conclusions: Cisplatin based chemo plus mediastinal radiotherapy may provide a chance of achieving a long-lasting remission in locally advanced TM. But, complete surgical removal of the tumor are still the mainstay of treatment.
PROTAMINE UTILIZATION AND CLINICAL OUTCOMES FOR CORONARY ARTERY PERFORATION IN CHRONIC TOTAL OCCLUSION PROCEDURES
Authors: Akash Kataruka, David Daniels, Chuck Maynard, Kathleen E. Kearney, Ahmed M. Mahmoud, Jacob Appel Doll, James M. McCabe, William Lombardi, Ravi Hira
Journal: Journal of the American College of Cardiology (2020)
A concerted cell and serum proteomic approach for the identification of oral squamous cell carcinoma biomarkers
Authors: A. M. Mlynarek, R. Balys, S. Jie, Y. Xu, M. P. Hier, M. J. Black, M. A. Alaoui-Jamali
Journal: Journal of Clinical Oncology (2006)

5512 Background: Head and neck squamous cell carcinoma is the sixth most common cause of cancer deaths in the world. Despite extensive research, the 5-year survival rates have not changed significantly over the last decade. Presently, the lack of serum biomarkers for head and neck carcinoma limits early diagnosis and treatment monitoring of advanced disease. In this study, we used a proteomic approach on serum from mice bearing human oral squamous cell carcinoma xenografts and from conditioned cell culture medium from matched cell lines. Methods: Oral squamous cell carcinomas, with distinct invasive phenotypes, and adjacent normal tissue were obtained from human patients, and were transplanted orthotopicaly into tongues of RAG-2/γ(c) mice. After a 20% weight loss, the mice were sacrificed by exsanguinations. Two distinct proteomic protocols were used to analyze the mouse serum. The first involved albumin depletion followed by two-dimensional gel electrophoresis and MALDI. The second arm utilized the same albumin depletion followed by multidimensional-protein-information-technology (ESI-LC and MS/MS). The top candidate proteins, which were differentially expressed in the cancer bearing mice compared to matched controls were then validated by Western blot, immunoprecipitation, immunofluorescence, and/or immunohistochemistry analyses using mouse serum and conditioned medium from matched cell lines. Results: Orthotopic implantation of human tumor tissues in mouse tongue was successful in 100% of the mice tested. The human origin of these tumors was confirmed pathologically. A correlation between disease stages and invasiveness was observed. We identified over one hundred proteins as being differentially expressed between control and cancer-bearing mice (p &lt; 0.05), including proteins involved in cell cytoskeleton signaling. The expression of these proteins was then validated in mouse serum, tissue xenografts, and conditioned medium from oral cancer matched established cell lines. Conclusion: We report the first proteomic in-vivo model of oral cancer for the identification of low molecular weight serum biomarkers. We identified candidates that can be exploited as potential markers for diagnosis of human oral squamous cell carcinoma. No significant financial relationships to disclose.
ARE COMPUTER-DERIVED INTERPRETATIONS OF ELECTROCARDIOGRAMS PREDICTIVE OF CLINICALLY SIGNIFICANT CARDIAC ABNORMALITIES ON TRANSTHORACIC ECHOCARDIOGRAMS?
Authors: Kyla D’Angelo, Juana Vargas, Gagan Verma, Daniel Kersten, Uzma Malik, Shlomo Shaulian, Roman Zeltser, Ofek Hai, Amgad Makaryus
Journal: Journal of the American College of Cardiology (2020)
Consensus guidelines for the definition, detection and interpretation of immunogenic cell death
Authors: Lorenzo Galluzzi, Ilio Vitale, Sarah Warren, Sandy Adjemian, Patrizia Agostinis, Aitziber Buqué Martinez, Timothy A Chan, George Coukos, Sandra Demaria, Eric Deutsch, Dobrin Draganov, Richard L Edelson, Silvia C Formenti, Jitka Fucikova, Lucia Gabriele, Udo S Gaipl, Sofia R Gameiro, Abhishek D Garg, Encouse Golden, Jian Han, Kevin J Harrington, Akseli Hemminki, James W Hodge, Dewan Md Sakib Hossain, Tim Illidge, Michael Karin, Howard L Kaufman, Oliver Kepp, Guido Kroemer, Juan Jose Lasarte, Sherene Loi, Michael T Lotze, Gwenola Manic, Taha Merghoub, Alan A Melcher, Karen L Mossman, Felipe Prosper, Øystein Rekdal, Maria Rescigno, Chiara Riganti, Antonella Sistigu, Mark J Smyth, Radek Spisek, John Stagg, Bryan E Strauss, Daolin Tang, Kazuki Tatsuno, Stefaan W van Gool, Peter Vandenabeele, Takahiro Yamazaki, Dmitriy Zamarin, Laurence Zitvogel, Alessandra Cesano, Francesco M Marincola
Journal: Journal for ImmunoTherapy of Cancer (2020)

Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation.
Application of an ointment with high radical protection factor as a prevention strategy against PPE.
Authors: Franziska Kluschke, Anja Martschick, Maxim E. Darvin, Leonhard Zastrow, Radoslav Chekerov, Juergen Lademann, Jalid Sehouli
Journal: Journal of Clinical Oncology (2012)

5064 Background: Pegylated liposomal doxorubicin has proved to be highly efficient in the treatment of various tumors. Depending on the application protocol, up to 80% of patients develop palmar-plantar erythrodysesthesia (PPE). So far, a prevention strategy is still unknown. Recently, it was shown that parts of the chemotherapeutics were excreted with the sweat onto the skin surface, spreading there homogeneously and penetrating into the stratum corneum. The formation of free radicals in the tissue results in PPE. The aim of the study was to investigate if a topically applied ointment containing antioxidants with high radical protection factor (RPF) can be a PPE prevention strategy. Methods: 20 patients with ovarian carcinoma, who had been treated with pegylated liposomal doxorubicin (40 mg/m 2 ), were investigated. They applied the ointment at least twice daily, 2 days before and during 3 cycles of chemotherapy. Their skin condition was examined by a trained dermatologist. Results: From 20 patients enrolled in the study, only 12 (60%) met the conditions by applying the cream at least twice daily in the palmar and plantar regions. These patients did not develop PPE. One patient died in the 2nd cycle of therapy. 7 patients (35%) did not follow the ointment application protocol for various reasons; 6 of them developed PPE and resumed ointment application thereafter. As a result, PPE disappeared or was strongly reduced in these patients so that chemotherapy could be continued. Due to the small group of patients, the fact that PPE was not induced in patients who had applied the ointment regularly can be generalized only restrictedly. Far more interesting are the findings in those patients, who had stopped ointment application during chemotherapy and developed PPE, which disappeared after they resumed applying the ointment. The regression or distinct reduction of PPE after re-application of the ointment clearly proves the efficacy of this strategy. Conclusions: The topical application of an ointment containing antioxidants with high radical protection factor (RPF) could be an efficient strategy against the development of PPE during chemotherapy.
Facility-Level Variation in Cardiac Stress Test Use Among Patients With Diabetes: Findings From the Veterans Affairs National Database
Authors: Dhruv Mahtta, Sarah T. Ahmed, Nishant R. Shah, David J. Ramsey, Julia M. Akeroyd, Khurram Nasir, Ihab R. Hamzeh, Islam Y. Elgendy, Stephen W. Waldo, Mouaz H. Al-Mallah, Hani Jneid, Christie M. Ballantyne, Laura A. Petersen, Salim S. Virani
Journal: Diabetes Care (2020)

Cardiac stress testing in patients with diabetes mellitus (DM) is a topic of much debate (1,2). The clinical heterogeneity and varied interpretation of atypical symptoms in this population may lead to significant variation in cardiac stress testing with downstream implications in health care expenditure. We evaluated facility-level variation in cardiac stress test use among patients with DM across the Veterans Affairs (VA) health care system.

We identified patients with DM aged ≥18 years with a primary care clinic visit during VA fiscal year 2014 at one of the 130 VA facilities and associated clinics. Patient demographics and medical history were identified using clinical data sources and ICD-9-CM codes. We calculated diagnostic cost group relative risk score (DCG-RRS), a validated surrogate for overall illness burden. Facility-level cardiac stress test use was defined as the number of stress tests performed per facility per 100 patients with DM in the preceding 365 days. Stress testing modalities evaluated included exercise treadmill test, stress echocardiography, and SPECT/PET MPI (myocardial perfusion imaging [single photon emission computed tomography or positron emission tomography]). Facilities with <10 studies/year were excluded. Median risk ratio (MRR), a well-established measure of facility-level variation (3), was derived by constructing multivariable hierarchical modified regression models adjusted for patient clustering and modeled patient characteristics as filter effects within each facility and individual facilities as a random effect (4). Unadjusted and adjusted MRRs (adjustment for patient, provider, and facility-level variables) were calculated for overall stress testing and individual stress modalities. MRR represents the likelihood of two …
COMPETITIVE SPORTS AFTER ABORTED SUDDEN CARDIAC DEATH DUE TO CORONARY ARTERY ANOMALY
Authors: Csulak Emese, Nora Sydo, Dávid Becker, István Hartyánszky, Csilla Czimbalmos, Hajnalka Vágó, Bálint Károly Lakatos, Attila Kovács, Bela Merkely
Journal: Journal of the American College of Cardiology (2020)
Scientists on the Spot: Calcium dynamics in heart function
Authors: Albano C Meli, Evangelia G Kranias
Journal: Cardiovascular Research (2020)

published or not.The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
COVID-19 in gastroenterology: a clinical perspective
Authors: John Ong, Barnaby Edward Young, Sharon Ong
Journal: Gut (2020)

We read with interest the article ‘Diarrhoea may be underestimated: a missing link in 2019 novel coronavirus’ by Liang et al .1 Indeed, we agree with the authors that diarrhoea may be an underestimated and under-reported symptom of coronavirus disease 2019 (COVID-19). Similar to data from China, fever and cough are the two most commonly reported symptoms of COVID-19 in Singapore; around 30% of cases were afebrile, which may have been due to intensive efforts at contact tracing.2 3 In contrast, while gastrointestinal symptoms appear to be infrequent in China (nausea and vomiting: 5.0% and diarrhoea: 3.7%), 17% of patients with COVID-19 in Singapore reported diarrhoea.3 Interestingly, SARS-CoV2 RNA was detected in 50% of patients’ stool samples but was not clearly associated with abdominal symptoms. In those with detectable faecal virus RNA, approximately half had diarrhoea and half had normal stool consistency.

Besides the gut, studies suggest SARS-CoV2 …
HIGH-SENSITIVITY C-REACTIVE PROTEIN AND ACUTE KIDNEY INJURY IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
Authors: Giancarlo Silvio Marenzi, Jeness Campodonico, Nicola Cosentino, Claudia Lucci, Valentina Milazzo, Marco Moltrasio, Katia Celentano, Maria Luisa Biondi, Monica De Metrio, Mara Rubino, Ivana Marana, Marco Grazi, Gianfranco Lauri
Journal: Journal of the American College of Cardiology (2020)
BPI20-013: A Systematic Review and Meta-Analysis on Mucocutaneous Toxicities Associated With Upfront Use of Immune Checkpoint Inhibitor and Anti-Angiogenic Tyrosine Kinase Inhibitor Combinations for Advanced Renal Cell Carcinoma
Authors: Nusrat Jahan, Francis Mogollon-Duffo, Miguel Quirch, Lukman Tijani, Shabnam Rehman
Journal: Journal of the National Comprehensive Cancer Network (2020)

"BPI20-013: A Systematic Review and Meta-Analysis on Mucocutaneous Toxicities Associated With Upfront Use of Immune Checkpoint Inhibitor and Anti-Angiogenic Tyrosine Kinase Inhibitor Combinations for Advanced Renal Cell Carcinoma" published on 20 Mar 2020 by National Comprehensive Cancer Network.
Clinical relevance of VEGF-receptor status in primary ovarian cancer: A pilot study for future biomarker analyses.
Authors: Pauline Wimberger, Issam Chebouti, Jan Dominik Kuhlmann, Rainer Kimmig, Eberhart Kuhlisch, Robert Lachmann, Sabine Kasimir-Bauer
Journal: Journal of Clinical Oncology (2013)

5556 Background: Antiangiogenic treatment in addition to platinum/taxane based chemotherapy was shown to improve progression-free survival in first- and second-line chemotherapy in ovarian cancer patients. Predictive markers for antiangiogenic treatment are of high interest. Therefore we investigated VEGF-receptor (VEGFR) expression as possible biomarker candidate in primary ovarian cancer tissue and its clinical impact. Methods: A total of 82 patients with primary ovarian cancer were enrolled into this study. Primary tumor tissue was analyzed for the expression of VEGFR1, VEGFR2 and VEGFR3 by immunhistochemistry. Moreover, the presence of circulating tumor cells (CTC) in the blood was detected by immunomagnetic enrichment and multiplex reverse transcriptase-polymerase chain reaction (Adnatest Ovarian Cancer, Adnagen). Disseminated tumor cells (DTC) in the BM were identified by immunocytochemistry using the pancytokeratin antibodyA45B/B3 and subsequent automatic detection based on staining and cytomorphology. Results: Positivity for at least one VEGFR was observed in 43% of cases. The positivity rates for VEGFR1, -2 and -3 were 34%, 17% and 27%, respectively. VEGFR-status of the primary tumor neither correlated with established clinicopathogical parameters (age, FIGO-stage, nodal status, grading, histological subtype) nor with the presence of CTC or DTC. In addition, VEGFR-status does not provide prognostic significance in regard to progression-free and overall survival (OS). Nevertheless, a trend was observed that patients, being positive for VEGFR3 at primary diagnosis, were more likely to experience suboptimal debulking (p = 0.074). CTC-positivity after adjuvant therapy significantly correlated with OS, but multivariable analysis showed only residual tumor as prognostic factor for OS. Conclusions: The VEGFR-family, albeit frequently expressed in our patient cohort, provided neither prognostic nor predictive relevance, but could probably be a predictor for debulking efficiency. The implementation of VEGFR-status into future biomarker studies should carefully be considered.
Lessons From the Rationale and Design Features of the ADAPTABLE Trial
Authors: Patrick T. O’Gara
Journal: JAMA Cardiology (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal