tbuckley/cabot-search huggingface dataset:
Abstract P3-03-30: Validity and safety of omission of axillary lymph node dissection among sentinel lymph node-positive breast cancer patients treated with mastectomy
Authors: A Matsumoto, Y Umemoto, H Jinno
Journal: Cancer Research (2019)

Abstract Background:American College of Surgeons Oncology Group Z0011 trial showed that axillary lymph node dissection (ALND) had no impact on recurrence and survival in patients with positive sentinel lymph node (SLN) after breast-conserving surgery. However, it is still unknown if the omission of ALND can be applicable to patients treated with mastectomy. The aim of this study wasto evaluate whether ALND could be safely omitted for patients with SLN–positive breast cancer after mastectomy. Methods: From a prospective database of 296 patients with clinically node-negative breast cancer who underwent mastectomy and sentinel lymph node biopsy (SLNB) from March 2006 to December 2016, 81 patients who had positive SLNs were selected. Patient characteristics and prognosis were compared between SLN-positive patients with and without ALND. Patients treated with neoadjuvant chemotherapy were excluded from the analysis. Lymphatic mapping was performed using a combined method of blue dye and radioisotope. Results: The median age of entire patients was 57.0 (range: 32-85) years and the median tumor size was 2.5 (range: 0.6-7.9) cm. Of 81 patients, 23 (28.4%) patients omitted ALND. Patients with SLNB alone were more likely to have smaller SLN involvements (p&amp;lt;0.001): micrometastasis was identified in 13 (56.5%) patients in SLNB-alone group and 9 (15.5%) patients in ALND group. The number of positive SLN was comparable between SLNB-alone (median: 1.0, range: 1-6) and ALND groups (median: 1.0, range: 1-5) (p=0.063). There was no significant difference in characteristics including age, tumor size and tumor subtypes between the two groups. Post-mastectomy radiotherapy was performed in 5 (21.7%) patients with SLNB alone and 16 (27.6%) patients with ALND (p=0.588). The majority of patients with macrometastatic SLN received adjuvant chemotherapy in both groups (83.3% vs. 75.5%, p=0.562). Twenty (87.0%) and 51 (87.9%) patients received adjuvant endocrine therapy in SLNB-alone and ALND group, respectively (p=0.584). After a median follow-up of 54.7 months, no axillary recurrence was observed in both groups and 5-year disease-free survival was not significantly different between the two groups (75.0% vs. 88.8%, p=0.489). Lymphedema was observed significantly more often after ALND than after SLNB (22.4% vs. 4.3%, p=0.045). Conclusions: These data suggested that ALND could be safely omitted in SLN-positive breast cancer patients treated with mastectomy and appropriate systemic therapy. Citation Format: Matsumoto A, Umemoto Y, Jinno H. Validity and safety of omission of axillary lymph node dissection among sentinel lymph node-positive breast cancer patients treated with mastectomy [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr P3-03-30.
Association Between Value-Based Incentive Programs and Catheter-Associated Urinary Tract Infection Rates in the Critical Care Setting
Authors: Heather E. Hsu, Rui Wang, Maximilian S. Jentzsch, Robert Jin, Donald Goldmann, Chanu Rhee, Grace M. Lee
Journal: JAMA (2019)

This before-after study examines the association between value-based incentive programs that link financial rewards and penalties to hospital performance on quality indicators and catheter-associated urinary tract infection outcomes in intensive care units (ICUs).
Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation
Authors: Yong Pan, Xiaoyan Hui, Ruby Lai Chong Hoo, Dewei Ye, Cyrus Yuk Cheung Chan, Tianshi Feng, Yu Wang, Karen Siu Ling Lam, Aimin Xu
Journal: Journal of Clinical Investigation (2019)

Persistent, unresolved inflammation in adipose tissue is a major contributor to obesity-associated metabolic complications. However, the molecular links between lipid-overloaded adipocytes and inflammatory immune cells in obese adipose tissues remain elusive. Here we identified adipocyte-secreted microRNA-34a (miR-34a) as a key mediator through its paracrine actions on adipose-resident macrophages. The expression of miR-34a in adipose tissues was progressively increased with the development of dietary obesity. Adipose-selective or adipocyte-specific miR-34a-KO mice were resistant to obesity-induced glucose intolerance, insulin resistance, and systemic inflammation, and this was accompanied by a significant shift in polarization of adipose-resident macrophages from proinflammatory M1 to antiinflammatory M2 phenotype. Mechanistically, mature adipocyte-secreted exosomes transported miR-34a into macrophages, thereby suppressing M2 polarization by repressing the expression of Krüppel-like factor 4 (Klf4). The suppressive effects of miR-34a on M2 polarization and its stimulation of inflammatory responses were reversed by ectopic expression of Klf4 in both bone marrow-derived macrophages and adipose depots of obese mice. Furthermore, increased miR-34a expression in visceral fat of overweight/obese subjects correlated negatively with reduced Klf4 expression, but positively with the parameters of insulin resistance and metabolic inflammation. In summary, miR-34a was a key component of adipocyte-secreted exosomal vesicles that transmitted the signal of nutrient overload to the adipose-resident macrophages for exacerbation of obesity-induced systemic inflammation and metabolic dysregulation.
Cytokine Release Syndrome after Peripheral Blood T-Cell Replete Haploidentical Transplantation Is Not Prevented By Dexamethasone and Limits Its Full-Outpatient Conduction
Authors: Perla R. Colunga Pedraza, Andrés Gómez-De León, Julia Esther Colunga Pedraza, Emmanuel Bugarin Estrada, Paola Santana-Hernandez, Olga Cantu Rodriguez, Cesar Homero Gutierrez Aguirre, Luz del Carmen Tarín Arzaga, José Miguel Yañez Reyes, David Gomez-Almaguer
Journal: Blood (2018)
Management of patients with heart failure with preserved versus reduced ejection fraction : a retrospective population-based cohort study in Sweden
Authors: J. Stalhammar, Kurt Boman, Mona Olofsson, G. Wikstrom, G. J. Bergman, M. Tornblom, V. Wintzell, S. Bruce Wirta, C. C. Proenca, R. Schlienger, Krister Lindmark
Journal: European Journal of Heart Failure (2017)
Abstract 21264: Age and Gender Related Left Atrial Remodeling With Magnetic Resonance Imaging: Multi Ethnic Study of Atherosclerosis
Authors: Bharath Ambale Venkatesh, Seoyoung Hong, Mohammadali Habibi, Daniel Lim, Enpei Wu, Neal Jorgenson, W. Gregory Hundley, Steven J Shea, Kiang Liu, Antoinette S Gomes, Susan Heckbert, Wendy S Post, David A Bluemke, Joao A Lima
Journal: Circulation (2017)

Introduction: Left atrial (LA) structure and function are associated with future cardiovascular (CV) events and risk factors. Studying the longitudinal change of LA structure and function with age may provide important insights into the natural history of LA remodeling. Hypothesis: The aim of this study is to evaluate associations between age and gender with longitudinal changes in LA remodeling in a large multi-ethnic cohort free of clinical CV disease at baseline. Methods: Cardiac magnetic resonance (CMR) was used to identify longitudinal changes in LA structure and function in 2882 MESA participants who underwent baseline (year 2000-2002) and 10-year follow-up CMR imaging. Multimodality tissue tracking (MTT, Toshiba) software was used to calculate LA structure (LA maximum, minimum and pre-atrial contraction volumes indexed to body surface area - LA Vmax, Vmin and VpreA) and function (LA total, passive and active emptying fraction, LATEF, LAPEF, and LAAEF). Data were analyzed with multivariable mixed-effects regression models in which the outcome was CMR LA measurements, and the covariates included follow-up time and CV risk factors (hypertension, diabetes, smoking, race/ethnicity, body mass index, and lipid levels). Results: Participants were aged 45-84 years at baseline, and 53% were women. At baseline, men had lower LATEF than women (58.4 vs 63.4%, p&lt;0.05), while they had similar LA Vmax (30.3 vs 29.9 ml/m2, p=NS) and larger Vmin (13.1 vs 11.5 ml/m2, p=NS). Median time between baseline and follow-up CMR imaging was 9.4 years. Over this period, LA Vmax and Vmin increased in both men (by 4.8 and 5.2 ml/m2 respectively, p&lt;0.05) and women (by 4.9 and 4.6 ml/m2 respectively, p&lt;0.05); while LATEF decreased in both (-7.3 % in women, and -6.1% in men, p&lt;0.05). Conclusions: In a population free of CV disease, at baseline women had higher LA function than men, as well as lower LA volumes. Aging was associated with increased LA volume and decreased LA function in both men and women.
Final Results from a Multicenter, Open-Label, Dose-Escalation Phase 1b/2 Study of Single-Agent Oprozomib in Patients with Hematologic Malignancies
Authors: Irene M. Ghobrial, Michael R. Savona, Ravi Vij, David S. Siegel, Ashraf Badros, Jonathan L. Kaufman, Noopur Raje, Andrzej Jakubowiak, Mihaela Obreja, Jesus G. Berdeja
Journal: Blood (2016)
Immunoglobulin Variable Region Gene Sequences Reveal N-Glycosylation Motifs As an Early and Stable Event in Follicular Lymphoma Pathology
Authors: Mariette Odabashian, Emanuela Carlotti, Shamzah Araf, Jessica Okosun, Francesco Forconi, Freda K Stevenson, John G. Gribben, Maria Calaminici, Sergey Krysov
Journal: Blood (2018)
Major Bleeding Rates in Atrial Fibrillation Patients on Single, Dual, or Triple Antithrombotic Therapy
Authors: Nienke van Rein, Uffe Heide-Jørgensen, Willem M. Lijfering, Olaf M. Dekkers, Henrik T. Sørensen, Suzanne C. Cannegieter
Journal: Circulation (2019)

Background: Patients with atrial fibrillation generally require anticoagulant therapy and, at times, therapy with additional platelet aggregation inhibitors. Data are scarce on bleeding rates in high-risk groups receiving combination therapy, such as the elderly or patients with a high CHA 2 DS 2 -VASc score. Methods: We conducted a nationwide cohort study of Danish patients with atrial fibrillation ≥50 years of age. Treatments were ascertained from a prescription database. These included no anticoagulant treatment, and treatment with vitamin K antagonists, direct oral anticoagulants, platelet inhibitors, and combinations of antithrombotic drugs. Incidence rates (IRs) of major bleeding and hazard ratios were estimated overall, and also stratified by treatment modality, age, CHA 2 DS 2 -VASc score, and comorbidity. Major bleeding was defined as bleeding requiring hospitalization or causing death. Results: We identified 272 315 patients with atrial fibrillation. Median age was 75 years (interquartile range, 67–83) and 47% were women. Over a total follow-up period of 1 373 131 patient-years (PYs), 31 459 major bleeds occurred (IR 2.3/100 PYs; 95% CI, 2.3–2.3/100 PYs). In comparison with vitamin K antagonist monotherapy, adjusted hazard ratios of major bleeding were 1.13 (95% CI, 1.06–1.19) for dual antiplatelet therapy, 1.82 (95% CI, 1.76–1.89) for therapy with a vitamin K antagonist and an antiplatelet drug, 1.28 (95% CI, 1.13–1.44) for therapy of a direct oral anticoagulant with an antiplatelet drug, 3.73 (95% CI, 3.23–4.31) for vitamin K antagonist triple therapy, and 2.28 (95% CI, 1.67–3.12) for direct oral anticoagulant triple therapy. Subgroup analyses showed similar patterns. The IR for major bleeding was 10.2/100 PYs among patients receiving triple therapy. Very high major bleeding rates occurred among patients on triple therapy aged &gt;90 years (IR 22.8/100 PYs) or with a CHA 2 DS 2 -VASc score &gt;6 (IR 17.6/100 PYs) or with a history of major bleeding (IR 17.5/100 PYs). Conclusions: Patients with atrial fibrillation on triple therapy experienced high rates of major bleeding in comparison with patients on dual therapy or monotherapy. The high bleeding rates observed in patients on triple therapy &gt;90 years of age or with a CHA 2 DS 2 -VASc score &gt;6 or with a history of a major bleeding warrants careful consideration of such therapy in these patients.
Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association
Authors: Emelia J. Benjamin, Paul Muntner, Alvaro Alonso, Marcio S. Bittencourt, Clifton W. Callaway, April P. Carson, Alanna M. Chamberlain, Alexander R. Chang, Susan Cheng, Sandeep R. Das, Francesca N. Delling, Luc Djousse, Mitchell S.V. Elkind, Jane F. Ferguson, Myriam Fornage, Lori Chaffin Jordan, Sadiya S. Khan, Brett M. Kissela, Kristen L. Knutson, Tak W. Kwan, Daniel T. Lackland, Tené T. Lewis, Judith H. Lichtman, Chris T. Longenecker, Matthew Shane Loop, Pamela L. Lutsey, Seth S. Martin, Kunihiro Matsushita, Andrew E. Moran, Michael E. Mussolino, Martin O’Flaherty, Ambarish Pandey, Amanda M. Perak, Wayne D. Rosamond, Gregory A. Roth, Uchechukwu K.A. Sampson, Gary M. Satou, Emily B. Schroeder, Svati H. Shah, Nicole L. Spartano, Andrew Stokes, David L. Tirschwell, Connie W. Tsao, Mintu P. Turakhia, Lisa B. VanWagner, John T. Wilkins, Sally S. Wong, Salim S. Virani
Journal: Circulation (2019)
Associations between Coarse Particulate Matter Air Pollution and Cause-Specific Mortality: A Nationwide Analysis in 272 Chinese Cities
Authors: Renjie Chen, Peng Yin, Xia Meng, Lijun Wang, Cong Liu, Yue Niu, Yunning Liu, Jiangmei Liu, Jinlei Qi, Jinling You, Haidong Kan, Maigeng Zhou
Journal: Environmental Health Perspectives (2019)

Background: Coarse particulate matter with aerodynamic diameter between 2.5 and 10μm (PM2.5–10) air pollution is a severe environmental problem in developing countries, but its challenges to public health were rarely evaluated. Objective: We aimed to investigate the associations between day-to-day changes in PM2.5–10 and cause-specific mortality in China. Methods: We conducted a nationwide daily time-series analysis in 272 main Chinese cities from 2013 to 2015. The associations between PM2.5–10 concentrations and mortality were analyzed in each city using overdispersed generalized additive models. Two-stage Bayesian hierarchical models were used to estimate national and regional average associations, and random-effect models were used to pool city-specific concentration–response curves. Two-pollutant models were adjusted for fine particles with aerodynamic diameter ≤2.5μm (PM2.5) or gaseous pollutants. Results: Overall, we observed positive and approximately linear concentration–response associations between PM2.5–10 and daily mortality. A 10-μg/m3 increase in PM2.5–10 was associated with higher mortality due to nonaccidental causes [0.23%; 95% posterior interval (PI): 0.13, 0.33], cardiovascular diseases (CVDs; 0.25%; 95% PI: 0.13, 0.37), coronary heart disease (CHD; 0.21%; 95% PI: 0.05, 0.36), stroke (0.21%; 95% PI: 0.08, 0.35), respiratory diseases (0.26%; 95% PI: 0.07, 0.46), and chronic obstructive pulmonary disease (COPD; 0.34%; 95% PI: 0.12, 0.57). Associations were stronger for cities in southern vs. northern China, with significant differences for total and cardiovascular mortality. Associations with PM2.5–10 were of similar magnitude to those for PM2.5 in both single- and two-pollutant models with mutual adjustment. Associations were robust to adjustment for gaseous pollutants other than nitrogen dioxide and sulfur dioxide. Meta-regression indicated that a larger positive correlation between PM2.5–10 and PM2.5 predicted stronger city-specific associations between PM2.5–10 and total mortality. Conclusions: This analysis showed significant associations between short-term PM2.5–10 exposure and daily nonaccidental and cardiopulmonary mortality based on data from 272 cities located throughout China. Associations appeared to be independent of exposure to PM2.5, carbon monoxide, and ozone. https://doi.org/10.1289/EHP2711
Epidermal growth factor-like repeats of SCUBE1 derived from platelets are critical for thrombus formation
Authors: Wei-Ju Liao, Meng-Ying Wu, Chen-Chung Peng, Yi-Chung Tung, Ruey-Bing Yang
Journal: Cardiovascular Research (2019)

Abstract Aims SCUBE1 [signal peptide-CUB-epidermal growth factor (EGF) domain-containing protein 1], expressed in endothelial cells (ECs) and platelets, exists in soluble or membrane forms. We previously showed that soluble SCUBE1 is a biomarker for platelet activation and also an active participant of thrombosis. However, whether the adhesive module of its EGF-like repeats is essential and the specific contribution of SCUBE1 synthesized in ECs or platelets to thrombosis in vivo remain unclear. Methods and results We generated new mutant (Δ2) mice lacking the entire EGF-like repeats to evaluate the module’s functional importance during thrombogenesis in vivo. The Δ2 platelet-rich plasma showed markedly impaired platelet aggregation induced by agonists including adenosine diphosphate, collagen, the thrombin agonist PAR-4 peptide and the thromboxane A2 analogue U46619. Consistently, genetic ablation of the EGF-like repeats diminished arterial thrombosis and protected Δ2 mice against lethal thromboembolism. On flow chamber assay, whole blood isolated from Δ2 or wild-type (WT) mice pre-treated with blocking antibodies against the EGF-like repeats showed a significant decrease in platelet deposition and thrombus formation on collagen-coated surfaces under arterial shear rates. Moreover, we created animals expressing SCUBE1 only in ECs (S1-EC) or platelets (S1-PLT) by reciprocal bone-marrow transplantation between WT and Δ2 mice. The time of carotid arterial thrombosis induced by ferric chloride was normal in S1-PLT chimeric mice but much prolonged in S1-EC animals. Conclusions We demonstrate that platelet-derived SCUBE1 plays a critical role in arterial thrombosis via its adhesive EGF-like repeats in vivo and suggest targeting these adhesive motifs of SCUBE1 for potential anti-thrombotic strategy.
Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population
Authors: Ken Suzuki, Masato Akiyama, Kazuyoshi Ishigaki, Masahiro Kanai, Jun Hosoe, Nobuhiro Shojima, Atsushi Hozawa, Aya Kadota, Kiyonori Kuriki, Mariko Naito, Kozo Tanno, Yasushi Ishigaki, Makoto Hirata, Koichi Matsuda, Nakao Iwata, Masashi Ikeda, Norie Sawada, Taiki Yamaji, Motoki Iwasaki, Shiro Ikegawa, Shiro Maeda, Yoshinori Murakami, Kenji Wakai, Shoichiro Tsugane, Makoto Sasaki, Masayuki Yamamoto, Yukinori Okada, Michiaki Kubo, Yoichiro Kamatani, Momoko Horikoshi, Toshimasa Yamauchi, Takashi Kadowaki
Journal: Nature Genetics (2019)
Abstract 13651: Right Ventricular Arterial Coupling Ratio Correlates With Right Ventricular Strain and Predicts Outcomes Using Three Dimensional Echocardiography in Pediatric Pulmonary Hypertension
Authors: Pei-Ni Jone, Michal Schäfer, Carlie Bremen, D. Dunbar Ivy
Journal: Circulation (2017)

Background: Right ventricular (RV) function is an important determinant of outcomes in pulmonary hypertension (PH) and RV strain is sensitive in evaluating function. RV-arterial coupling ratio using stroke volume to end-systolic volume (SV/ESV) has been shown to be an independent predictor of outcome in adults with PH. SV/ESV ratio has not been used in pediatrics to predict outcomes. Three-dimensional echocardiography (3DE) can generate RV volumes and strain. In this study, we used 3DE to evaluate the relationship of SV/ESV to RV strain and outcomes in pediatric PH. Methods: Ninety-six children with PH (mean age 8.1 ± 5.2yrs; 45% male) underwent 3DE (211 studies) from 2014-2016. Offline analysis generated 3D end-diastolic volume, ESV, SV, ejection fraction, and RV free wall longitudinal strain (LS). Adverse clinical events included: death, lung transplant, atrial septostomy, Pott’s shunt, intravenous prostacyclin, or PH related hospitalization with increased RV failure or hemoptysis. SV/ESV was compared b...
Carcinoids of the ampulla: Long-term follow-up after endoscopic resection.
Authors: George Nyasha Baison, Nadav Sahar, Morgan M Bonds, Janelle F Rekman, Flavio G. Rocha, Shayan Irani
Journal: Journal of Clinical Oncology (2019)

430 Background: Neuroendocrine tumors (NET) or carcinoids of the ampulla are exceedingly rare in comparison to duodenal NET. Surgical management is widely accepted as the treatment of choice, but for patients that refuse surgery or are poor operative candidates, endoscopic resection may be option. We present a consecutive case series at a tertiary care center describing our experience with endoscopic resection of ampullary NET. Methods: This is a restrospective review with a long-term follow-up of patients with ampullary NET that were endoscopically resected. Outcomes were analyzed based on the histopathologic classification system proposed by the World Health Organization in 2000. Results: Twelve patients (9 male, 3 female), ranging in age from 41 to 86 (mean 59) underwent endoscopic ampullectomy for ampullary NET, with a mean follow-up time of 5 years. Patients had refused surgery or were poor surgical candidates. All, but one incidentally found case, were symptomatic on presentation, with gastrointestinal bleeding being the main symptom. No patients had a hormonal syndrome. The mean size of the lesions was 21 mm (6 mm to 35 cm). Six (50%) patients had a well-differentiated, benign lesion, 6 (50%) patients had a well-differentiated NET with unknown malignant potential (gangliocytic paragangliomas). Eight (67%) were completely excised during the initial endoscopy with 4 requiring re-excision. Only 2 patients developed recurrence, after 2.5 and 10 years and this necessitated a pancreaticoduodenectomy. Five patients had complications (2 for bleeding and 3 for post-ERCP pancreatitis), with zero deaths. Conclusions: Unlike duodenal carcinoids, ampullary NET are rare. Pancreaticoduodenectomy can be offered to fit patients except for gangliocytic paragangliomas that do not require an aggressive operation. However, for those that refuse surgery or are poor candidates, endoscopic ampullectomy can be an option with acceptable short and long-term outcomes.
Pharmacologic Treatment for Neonatal Abstinence Syndrome
Authors: Elisha M. Wachman, Martha M. Werler
Journal: JAMA Pediatrics (2019)

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Hobit- and Blimp-1-driven CD4+ tissue-resident memory T cells control chronic intestinal inflammation
Authors: Sebastian Zundler, Emily Becker, Marta Spocinska, Monique Slawik, Loreto Parga-Vidal, Regina Stark, Maximilian Wiendl, Raja Atreya, Timo Rath, Moritz Leppkes, Kai Hildner, Rocío López-Posadas, Sören Lukassen, Arif B. Ekici, Clemens Neufert, Imke Atreya, Klaas P. J. M. van Gisbergen, Markus F. Neurath
Journal: Nature Immunology (2019)