tbuckley/cabot-search huggingface dataset:
AB0259 THE RELATIONSHIP BETWEEN MICROVASCULAR DAMAGE AND DISEASE ACTIVITY IN PATIENT WITH RHEUMATOID ARTHRITIS – ASSESSMENT BY VIDEOCAPILAROSCOPY
Authors: M. Parvu, A. Cozos, A. I. Biro, H. V. Popoviciu
Journal: Annals of the Rheumatic Diseases (2020)

Background: Rheumatoid arthritis (RA) is an autoimmune disease characterized by erosive synovitis (causing severe joint damage) and systemic damage. Rheumatoid vasculitis (RV) is an extra-articular manifestation of rare but serious rheumatoid disease that involves the damage of small and medium sized vessels. Objectives: The purpose of the study was to evaluate the incidence of damages occurred on cutaneous level in patients diagnosed with RA and to detect capillaroscopic microangiopathy changes in the activity of rheumatoid disease. Methods: 101 patients were included in the study, all were diagnosed with RA according to the ACR/EULAR 2010 criteria. RV diagnosis was based on the clinical examination. The capillaroscopic evaluation was performed with a 3.0 VideoCap device at a 200x magnification (200x magnification contact lenses). Capillaroscopic examination was performed on fingers II-V of both hands, being considered pathological if the capillaroscopic changes are present in at least two fingers. The activity of disease was calculated using DAS 28 ESR score. Results: 18% of examined patients was male and 82% female, with the mean age of 56,2years±10.16SD, and the mean duration of the disease in years of illness was 8.65±5.31SD. 3 patients had periungual vasculitis with cutaneous ulceration and gangrene, 12 patients had palpable purpura. 29% of the patients had vasospastic skin changes. The activity score of RA was associated with the capillaroscopic changes in peripheral microangiopathy p-0.037. Capillaries images were heterogenous in aspects and distribution, tortuous capillaries, microhemorrhages, giant/dilated capillaries, avascular areas were observed. Conclusion: Vascular microangiopathy evidenced by capillaroscopic examination is present in patients with cutaneous vasculitis having a medium, severe activity of rheumatoid diseases. References: [1]Cutolo M, Paolino S, Smith V. Nailfold capillaroscopy in rheumatology: ready for daily use but care in terminology. Clinical Rheumatology 2019; 38:2293-2297 http://doi.org/10/s10067-019-04716-w [2]Lambova N, Müller-Ladner U. Capillaroscopic pattern in inflammatory arthritis. Microvascular Research 2012; 83:318-322 Dilated, giant capillaries, microhemorrhage bleedings, avascular area Reduced blood flow (observed in dynamics) Disclosure of Interests: Mirela Parvu Speakers bureau: Not for this subject, theme, Anca Cozos Speakers bureau: Not for this subject, theme, Anna-Iuliana Biro Speakers bureau: Not for this subject, theme, Horatiu Valeriu Popoviciu Speakers bureau: Not for this subject, theme
Factors Associated with Clinical Outcomes after Venetoclax-Based Combination Therapy in Acute Myeloid Leukemia and High-Grade Myeloid Neoplasms
Authors: Yazan F. Madanat, Hetalkumari Patel, Omik Patel, Jingsheng Yan, Jude Khatib, Madhuri Vusirkala, Suleyman Y Goksu, Chul Ahn, Prapti A. Patel, Robert H. Collins, Stephen Chung
Journal: Blood (2020)
Impact of Daratumumab on Stem Cell Collection, Graft Composition and Engraftment Among Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplant
Authors: Shivaprasad Manjappa, Robert Fox, Jane Reese, Amin Firoozamand, Hannah Schmikla, Savannah Nall, Merle Kolk, Paolo F Caimi, James J. Driscoll, Marcos de Lima, Ehsan Malek
Journal: Blood (2020)
Predictive Biomarkers of Response to Venetoclax in Combination with Cobimetinib in Relapsed/Refractory Multiple Myeloma (RRMM)
Authors: Aparna Raval, Habib Hamidi, Olivia Hwang, Cherie Green, Catarina Maia, Marta Lasa, Maika Onishi, Paula Rodriguez-Otero, Jesús F. San-Miguel, Jorge D. Gallo, Bruno Paiva, Fredrik Schjesvold
Journal: Blood (2020)
Human umbilical cord-derived mesenchymal stem cell therapy ameliorate lupus through increasing CD4+ T cell senescence via MiR-199a-5p/Sirt1/p53 axis
Authors: Tao Cheng, Shuai Ding, Shanshan Liu, Yan Li, Lingyun Sun
Journal: Theranostics (2020)

Rationale: Although human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) transplantation has been proved to be an effective therapeutic approach to treat systemic lupus erythematosus (SLE), the detailed underlying mechanisms are not fully understood.Transferring miRNAs is one mean by which MSCs communicate with surrounding cells.Sirt1 is a NAD-dependent deacetylase that protects against cell senescence by deacetylating p53.Here we aimed to explore whether hUC-MSCs affected senescence of splenic CD4+ T cells through regulating Sirt1/p53 via miRNA in the MRL/lpr lupus mouse model.Methods: The effects of hUC-MSCs on lupus syndrome and senescence pathways in MRL/lpr mice in vivo and in vitro were determined.The functional roles of miR-199a-5p in splenic CD4+ T cell senescence were studied by miRNA mimic or inhibitor in vitro.MRL/lpr mice were injected with miR-199a-5p agomir to evaluate the effects of miR-199a-5p on splenic CD4+ T cell senescence and disease in vivo.Results: We showed that hUC-MSCs transplantation ameliorated lupus symptoms and increased senescence of splenic CD4+ T cells through Sirt1/p53 signaling via miR-199a-5p in MRL/lpr mice.Moreover, systemic delivery of miR-199a-5p in MRL/lpr mice increased splenic CD4+ T-cell senescence, mimicking the therapeutic effects of transplanted hUC-MSCs.Conclusions: We have identified miR-199a-5p as one of the mechanisms employed by hUC-MSCs to alleviate lupus disease associated pathologies in MRL/lpr mice, which is attributable for promoting splenic CD4+ T cell senescence through Sirt1/p53 pathway.
Screening for Adverse Childhood Experiences
Authors: Jeoffry B. Gordon, Charles B. Nemeroff, Vincent Felitti
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Effect of Fedratinib, a Selective Inhibitor of Janus Kinase 2 (JAK2), on Weight and Metabolic Parameters in Patients with Intermediate (INT)- or High-risk Myelofibrosis (MF)
Authors: Douglas Tremblay, Lara Cavalli, Sibabrata Raja Banerjee, Shelonitda Rose, John Mascarenhas
Journal: Blood (2020)
Sting Negatively Regulates Allogeneic T-Cell Responses By Constraining Antigen-Presenting Cell Function
Authors: Yongxia Wu, Chih-Hang Anthony Tang, Corey Mealer, David Bastian, Mohammed Hanief Sofi, Linlu Tian, Steven Douglas Schutt, Hee-Jin Choi, Taylor Ticer, Mengmeng Zhang, Lei Huang, Andrew L. Mellor, Chih-Chi Andrew Hu, Xue-Zhong Yu
Journal: Blood (2020)
<i>CARD11</i> Mutation Induces Oligoclonal Expansion of T-Cells, and Accelerates ATL Development in Combination with HBZ
Authors: Takuro Kameda, Kotaro Shide, Ayako Kamiunten, Tahira Yuki, Masaaki Sekine, Keiichi Akizuki, Tomonori Hidaka, Yoko Kubuki, Midori Sugiyama, Daisuke Morishita, Kazuya Shimoda
Journal: Blood (2020)
The Internet as a Route to Health Information, Support, and Healthcare for Cancer Survivors
Authors: Jacqueline L. Bender
Journal: Journal of the National Comprehensive Cancer Network (2020)

ith advances in detection and increasingly sophisticated treatments, two- thirds of people who are diagnosed with cancer will become long-term survivors. 1This means that most cancer survivors will live .5 years after their diagnosis. 1In fact, it is estimated that there are .16.9 million cancer survivors alive in the United States today, and that number is expected to grow to $22.2 million by 2030 with the growth and aging of our population. 2he growing number of cancer survivors represents both a success and a challenge, which will require innovative models of care and support. 3This includes internet use. 4 As explained by Young Adult Cancer Canada, "it takes longer to recover from cancer than to treat it" (Karine Chalifour, BSW, Young Adult Cancer Canada, personal email communication, October 2020).6][7] Many of these supportive care issues are neglected or not adequately addressed because of the fractured nature of care delivery, the lack of survivorship programs or processes or incentives to permit their timely management, 3,8,9 or the patient's location. 10As a result, many patients with cancer report being dissatisfied with the information and support they receive from health professionals, 11 and struggle with high levels of unmet supportive care needs. 124][15] Relevant information from credible health websites can dispel fears, enhance feelings of control, promote self-care, and decrease anxiety, 13,14 and emotional support from online groups can buffer distress by normalizing experiences, thereby lessening negative appraisals of events and promoting coping efforts. 15ationally representative, up-to-date data on the prevalence of internet use is needed to inform patient education and supportive care services for cancer survivors.In this issue of JNCCN, using 2013-2018 data from the National Health Interview Survey, Dee et al 4 report on a cross-sectional analysis of general and health-related internet use among cancer survivors in the United States.In this study, more than two-thirds of respondents were internet users, with internet usage increasing over the 5-year period studied.Among this sample of 12,970 adult survivors, general internet use increased from 63.2% to 70.8%, and healthspecific internet use increased from 48.9% to 52.2% between 2013 and 2018.Other population-based studies using data from the Health Information National Trends Survey have reported similar internet use rates among cancer survivors in the United States. 16lthough the internet has the potential to reduce healthcare inequalities by providing individuals with access to information and support that might otherwise be inaccessible, 10 experts have concerns that it may conversely perpetuate healthcare disparities by keeping certain segments of the population See page 1468 for related article.
The secreted tyrosine kinase VLK is essential for normal platelet activation and thrombus formation
Authors: Leila Revollo, Glenn Merrill-Skoloff, Karen De Ceunynck, James R. Dilks, Shihui Guo, Mattia R. Bordoli, Christian G. Peters, Leila Noetzli, Andreia Ionescu, Vicki Rosen, Joseph E. Italiano, Malcolm Whitman, Robert Flaumenhaft
Journal: Blood (2021)
COVID-19 response in central Asia
Authors: Vijay Shankar Balakrishnan
Journal: The Lancet Microbe (2020)

At the time of writing, Worldometer reports, per million population, 8325 COVID-19 cases and 172 deaths in Kyrgyzstan, 5841 cases and 95 deaths in Kazakhstan, 1923 cases and 16 deaths in Uzbekistan, and 1109 cases and 8 deaths in Tajikistan.
AhR activation attenuates calcium oxalate nephrocalcinosis by diminishing M1 macrophage polarization and promoting M2 macrophage polarization
Authors: Xiaoqi Yang, Haoran Liu, Tao Ye, Chen Duan, Peng Lv, Xiaoliang Wu, Jianhe Liu, Kehua Jiang, Hongyan Lu, Huan Yang, Ding Xia, Ejun Peng, Zhiqiang Chen, Kun Tang, Zhangqun Ye
Journal: Theranostics (2020)

Calcium oxalate (CaOx) crystal can trigger kidney injury, which contributes to the pathogenesis of nephrocalcinosis. The phenotypes of infiltrating macrophage may impact CaOx-mediated kidney inflammatory injury as well as crystal deposition. How aryl hydrocarbon receptor (AhR) regulates inflammation and macrophage polarization is well understood; however, how it modulates CaOx nephrocalcinosis remains unclear. Methods: Mice were intraperitoneally injected with glyoxylate to establish CaOx nephrocalcinosis model with or without the treatment of AhR activator 6-formylindolo(3,2-b)carbazole (FICZ). Positron emission tomography computed tomography (PET-CT) imaging, Periodic acid-Schiff (PAS) staining, and polarized light optical microscopy were used to evaluate kidney injury and crystal deposition in mice kidney. Western blotting, immunofluorescence, chromatin immunoprecipitation, microRNA-fluorescence in situ hybridization, and luciferase reporter assays were applied to analyze polarization state and regulation mechanism of macrophage. Results: AhR expression was significantly upregulated and negatively correlated with interferon-regulatory factor 1 (IRF1) and hypoxia inducible factor 1-alpha (HIF-1α) levels in a murine CaOx nephrocalcinosis model following administration of FICZ. Moreover, AhR activation suppressed IRF1 and HIF-1α levels and decreased M1 macrophage polarization in vitro. In terms of the mechanism, bioinformatics analysis and chromatin immunoprecipitation assay confirmed that AhR could bind to miR-142a promoter to transcriptionally activate miR-142a. In addition, luciferase reporter assays validated that miR-142a inhibited IRF1 and HIF-1α expression by directly targeting their 3'-untranslated regions. Conclusions: Our results indicated that AhR activation could diminish M1 macrophage polarization and promote M2 macrophage polarization to suppress CaOx nephrocalcinosis via the AhR-miR-142a-IRF1/HIF-1α pathway.
FRI0550 CAN CYTOKINE GENE POLYMORPHISMS BE USEFUL FOR THE THERAPEUTIC CHOICE IN JAPANESE PATIENTS WITH RHEUMATOID ARTHRITIS?
Authors: S. Tsujimoto, M. Shigesaka, A. Tanaka, Y. Ozaki, T. Ito, M. Inaba, S. Nomura
Journal: Annals of the Rheumatic Diseases (2020)

Background: Rheumatoid arthritis (RA) is a common autoimmune disease. It is characterized by systemic synovitis with bone erosion and joint cartilage degradation(1). Production of autoantibody is important for autoimmune disease. Cytokines play crucial roles in its pathogenesis(2). SNP distribution varies between races. Few studies have examined SNP targeted at Japanese patients. The analysis of cytokine gene polymorphisms is important factor of pathophysiology and treatment. Objectives: This analysis was aimed to investigate the association between cytokine gene polymorphisms and autoantibody and therapeutic response in Japanese RA patients. Methods: This study subjects consisted of 100 RA patients and 50 healthy controls. We extracted data on patient sex, age, disease duration, rheumatoid factor (RF), anti cyclic citrullinated peptide (anti-CCP) antibody and therapeutic response including methotrexate (MTX) and biological DMARDs. Genomic DNA was isolated from peripheral blood, these were genotyped for TNFα, TGFβ 1 , IL-6, IL-10 and IFNγ polymorphisms. We analyzed these data using a chi-square test. Results: IL-10 (-819 C/T and -592 C/A) revealed that there were significant decrease in the frequency of IL-10 (-819) CC genotype and (-592) CC genotype as compared to controls in RA patients. Genotyping of IL-10 showed that there was significant decrease ACC/ACC genotype (Table 1). IFNγ (+874 A/T) revealed that there was significant decrease in the frequency of TT genotype as compared to controls (Table 1). No significant differences in TNFα, TGFβ 1 and IL-6 genotypes and alleles frequency were observed between RA patients and control. TGFβ 1 (+869 A/T) in patients with anti-CCP antibody positive revealed that there was significant decrease in the frequency of TT genotype as compared to patients with anti-CCP antibody negative (Table 2). No significant association between RF and any cytokine gene polymorphism. Analyzing cytokine gene polymorphisms could be useful for treatment with MTX and biological DMARDs. Table 1. Table 2. Conclusion: IL-10 (-819 C/T, -592 C/A) and IFNγ (+874 A/T) polymorphism might be related to RA in Japanese population. In addition, TGFβ 1 (+869 A/T) polymorphism might be associated with the production of anti-CCP antibody. These results suggest that the analyzing cytokine gene polymorphisms may offer promise as useful factors in the choice of treatment for Japanese RA patients. References: [1] Scott DL, Wolfe F, Huizinga TW. Rheumatoid arthritis. Lancet. 2010; 376: 1094–108. [2] McInnes IB, Schett G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol. 2007 Jun;7(6):429-42. Disclosure of Interests: None declared
Immune Infiltrate in the Primary Tumor Predicts Effect of Adjuvant Radiotherapy in Breast Cancer; Results from the Randomized SweBCG91RT Trial
Authors: Axel Stenmark Tullberg, Henri A.J. Puttonen, Martin Sjöström, Erik Holmberg, S. Laura Chang, Felix Y. Feng, Corey Speers, Lori J. Pierce, Dan Lundstedt, Fredrika Killander, Emma Niméus, Anikó Kovács, Per Karlsson
Journal: Clinical Cancer Research (2020)

Tumor-infiltrating immune cells play a key role in tumor progression. The purpose of this study was to analyze whether the immune infiltrate predicts benefit from postoperative radiotherapy in a large randomized breast cancer radiotherapy trial.In the SweBCG91RT trial, patients with stage I and II breast cancer were randomized to breast-conserving surgery (BCS) and postoperative radiotherapy or to BCS only and followed for a median time of 15.2 years. The primary tumor immune infiltrate was quantified through two independent methods: IHC and gene expression profiling. For IHC analyses, the absolute stromal area occupied by CD8+ T cells and FOXP3+ T cells, respectively, was used to define the immune infiltrate. For gene expression analyses, immune cells found to be prognostic in independent datasets were pooled into two groups consisting of antitumoral and protumoral immune cells, respectively.An antitumoral immune response in the primary tumor was associated with a reduced risk of breast cancer recurrence and predicted less benefit from adjuvant radiotherapy. The interaction between radiotherapy and immune phenotype was significant for any recurrence in both the IHC and gene expression analyses (P = 0.039 and P = 0.035) and was also significant for ipsilateral breast tumor recurrence in the gene expression analyses (P = 0.025).Patients with an antitumoral immune infiltrate in the primary tumor have a reduced risk of any recurrence and may derive less benefit from adjuvant radiotherapy. These results may impact decisions regarding postoperative radiotherapy in early breast cancer.
Abstract 14180: Impact of Hyperuricemia on Mortality Related to Aortic Diseases
Authors: Yoichiro Otaki, Tetsu Watanabe, Tsuneo Konta, Masafumi Watanabe
Journal: Circulation (2019)

Introduction: Despite advances in medicine, aortic diseases (ADs) such as aortic dissection and aortic aneurysm rupture remain fatal and have extremely high mortality rates. Owing to the relatively...
Abstract 493: An Age-associated Reduction in Na <sub>V</sub> 1.5 Protein Expression Correlates With an Increase in Na <sub>V</sub> 1.8 Protein Expression in the Right Atrial Appendage of the Human Heart
Authors: Emmanuel Isaac, Stephanie Cooper, Matthew K Lancaster, Mahmoud loubani, Sandra A Jones
Journal: Circulation Research (2020)

Background: Na v 1.5 is the predominantly expressed voltage-gated sodium channel (VGSC) isoform in the heart, responsible for phase 0 of the action potential. Our rodent studies have shown expression of neuronal isoform Na v 1.8 protein in the adult heart. Others have associated Na v 1.8 expression with aberrant sodium currents leading to increased frequency of arrhythmogenic episodes. Aim: To investigate age-associated changes in the protein expression of VGSCs Na v 1.5 and Na v 1.8 in the right atrial appendage of the human heart. Methods: Tissues from the right atrial appendage were obtained with NHS ethical approval (IRAS 197493) from patients undergoing routine cardiac surgery, coronary artery bypass or valve repair. The protein expression of VGSC isoforms Na v 1.5 and Na v 1.8 were quantified using specific protein-directed primary antibodies (Alomone, Israel) coupled with a secondary antibody conjugated to HRP for western blot (Abcam, UK), or Alexa Fluor 488 (ThermoFisher, UK) for immunohistochemistry with confocal microscopy (LSM 710 Zeiss, UK). Densities were quantified using Image J software. Results: Derived from 26 patients, the protein expression of Na v 1.5 arranged in chronological age order (43-87 years of age) demonstrated a negative correlation between increasing age and Na v 1.5 protein expression (Pearson correlation coefficient of -0.25). The contrary was shown for Na v 1.8, which had a positive correlation with increasing age (Pearson correlation coefficient of 0.26), as older patients show increased Na v 1.8 protein expression. This novel finding was reflected when we compared confocal images from elderly patients with their younger counterparts, as the elderly showed a higher density of labelled Na v 1.8 protein and a lower density of labelled Na v 1.5 protein, particularly located at the t-tubules and intercalated disks. Conclusion: With increasing chronological age, the human heart reduces expression of the predominant cardiac isoform Na v 1.5 whilst increasing the expression of Na v 1.8: This finding has the potential to increase the risk of an elderly person’s heart to an increased susceptibility of arrhythmias.
Mechanisms of the Anti-Tumor Activity of STAT3 Degraders in Lymphoma
Authors: Haojing Rong, Kirti Sharma, Fred Csibi, Bin Yang, Scott Rusin, Yatao Shi, Joyoti Dey, Rahul Karnik, Michele Mayo, Karen Yuan, Yogesh Chutake, Alice McDonald, Sean Zhu, Nan Ji, Phillip Liu, Henry Li, Duncan Walker, Jared Gollob, Nello Mainolfi, Chris Desavi
Journal: Blood (2020)