tbuckley/cabot-search huggingface dataset:
Safety, anti-tumour activity, and biomarker results of the HER2-targeted bispecific antibody ZW25 in HER2-expressing solid tumours
Authors: D.-Y. Oh, E. Hamilton, D. Hanna, M. Beeram, K.-W. Lee, Y.-K. Kang, J. Chaves, J.-Y. Lee, R. Goodwin, C. Vaklavas, S.-Y. Rha, E. Elimova, J. Mayordomo, C. Ferrario, M. Cobleigh, A. Fortenberry, G. Rowse, T. Gray, R. Lai, F. Meric Bernstam
Journal: Annals of Oncology (2019)
Differential Effects of Three Small Molecules Blocking Phosphatidylinositol-3 Kinase or AKT in Hodgkin Disease Cell Lines: Induction of Apoptosis and Cell Cycle Arrest.
Authors: Georgios V. Georgakis, Yang Li, Georgios Z. Rassidakis, Jeffrey L. Medeiros, Gordon B. Mills, Anas Younes
Journal: Blood (2004)
A Phase II Study of Chlorambucil Plus Rituximab Followed by Maintenance Versus Observation In Elderly Patients with Previously Untreated Chronic Lymphocytic Leukemia: Results of the First Interim Analysis
Authors: Robin Foa, Stefania Ciolli, Francesco Di Raimondo, Giovanni Del Poeta, Francesco Lauria, Francesco Forconi, Antonio Cuneo, Agostino Cortellezzi, Giorgio Lambertenghi Deliliers, Vincenzo Callea, Francesco Nobile, Maura Brugiatelli, Massimo Massaia, Stefano Molica, Livio Trentin, Rita Rizzi, Giorgina Specchia, Lorella Orsucci, Achille Ambrosetti, Marco Montillo, Pier Luigi Zinzani, Felicetto Ferrara, Fortunato Morabito, Maria Angela Mura, Silvia Soriani, Simona Santangelo, Marilisa Marinelli, Maria Stefania De Propris, Francesca Romana Mauro, Eva J. Runggaldier, Enrica Gamba, Anna Guarini
Journal: Blood (2010)
Expression of Cereblon (CRBN) Is Associated with Disease Stage, Genetic Subgroups and Specific Micro-RNAs in Multiple Myeloma
Authors: Florian Kuchenbauer, Johannes Bloehdorn, Miriam Kull, Peter Liebisch, Veronica Teleanu, Britta Kopp, Stefan Knop, Christian Straka, Hermann Einsele, Hartmut Döhner, Christian Langer
Journal: Blood (2012)
Comparison of Burkitt Lymphoma (BL) and B-Cell Lymphoma, Unclassifiable with Features Intermediate Between Diffuse Large B-Cell Lymphoma and Burkitt Lymphoma (BCL-U) Patient Outcomes: Intensive Therapy May Not Benefit BCL-U
Authors: Naresh Bumma, Lisa Rybicki, Paolo Caimi, Deepa Jagadeesh, Robert M Dean, Brad Pohlman, Mitchell R. Smith, Brian T. Hill
Journal: Blood (2014)
Beta2-Glycoprotein I: Implications for a Regulatory Role in Thrombotic Thrombocytopenic Purpura.
Authors: Bas de Laat, Johanna A. Kremer Hovinga, Wouter Pos, Evelyn Groot, Jing-Fei Dong, Bernard Lammle, Jan Voorberg, Philip G. de Groot
Journal: Blood (2007)
HARMONY: An Open-Label, Multicenter, 2-Arm, Dose-Finding, Phase 1b Study of the Combination of Ruxolitinib and Buparlisib (BKM120) in Patients with Myelofibrosis (MF)
Authors: Simon Durrant, Maya Koren-Michowitz, David Lavie, Joaquin Martinez-Lopez, Alessandro M. Vannucchi, Francesco Passamonti, Viktoriya Stalbovskaya, Edric Atienza, Dana Iommazzo, Prashanth Gopalakrishna, Heinz Gisslinger
Journal: Blood (2014)
Treatment With Hedgehog Inhibitor, PF-04449913, Attenuates Leukemia-Initiation Potential In Acute Myeloid Leukemia Cells
Authors: Nobuaki Fukushima, Yosuke Minami, Fumihiko Hayakawa, Hitoshi Kiyoi, Anil Sadarangani, Catriona HM Jamieson, Tomoki Naoe
Journal: Blood (2013)
RAD001, An Inhibitor of mTOR, Enhances Monocytic Differentiation Induced by ATRA through Phosphorylation of C/EBPα In AML Cell Lines
Authors: Hideki Yoshida, Toshihiko Imamura, Atsushi Fujiki, Yoshifumi Hirashima, Mitsuru Miyachi, Kanji Sugita, Hajime Hosoi
Journal: Blood (2010)
Ovarian damage from chemotherapy and current approaches to its protection
Authors: N Spears, F Lopes, A Stefansdottir, V Rossi, M De Felici, R A Anderson, F G Klinger
Journal: Human Reproduction Update (2019)

Anti-cancer therapy is often a cause of premature ovarian insufficiency and infertility since the ovarian follicle reserve is extremely sensitive to the effects of chemotherapy and radiotherapy. While oocyte, embryo and ovarian cortex cryopreservation can help some women with cancer-induced infertility achieve pregnancy, the development of effective methods to protect ovarian function during chemotherapy would be a significant advantage.This paper critically discusses the different damaging effects of the most common chemotherapeutic compounds on the ovary, in particular, the ovarian follicles and the molecular pathways that lead to that damage. The mechanisms through which fertility-protective agents might prevent chemotherapy drug-induced follicle loss are then reviewed.Articles published in English were searched on PubMed up to March 2019 using the following terms: ovary, fertility preservation, chemotherapy, follicle death, adjuvant therapy, cyclophosphamide, cisplatin, doxorubicin. Inclusion and exclusion criteria were applied to the analysis of the protective agents.Recent studies reveal how chemotherapeutic drugs can affect the different cellular components of the ovary, causing rapid depletion of the ovarian follicular reserve. The three most commonly used drugs, cyclophosphamide, cisplatin and doxorubicin, cause premature ovarian insufficiency by inducing death and/or accelerated activation of primordial follicles and increased atresia of growing follicles. They also cause an increase in damage to blood vessels and the stromal compartment and increment inflammation. In the past 20 years, many compounds have been investigated as potential protective agents to counteract these adverse effects. The interactions of recently described fertility-protective agents with these damage pathways are discussed.Understanding the mechanisms underlying the action of chemotherapy compounds on the various components of the ovary is essential for the development of efficient and targeted pharmacological therapies that could protect and prolong female fertility. While there are increasing preclinical investigations of potential fertility preserving adjuvants, there remains a lack of approaches that are being developed and tested clinically.
Decreased Expression of Indoleamine 2,3-Dioxygenase 1 in Dendritic Cells From Patients with Immune Thrombocytopenia Induces Impaired Regulatory T-Cell Development
Authors: Lucia Catani, Daria Sollazzo, Sara Trabanelli, Cecilia Evangelisti, Antonio Curti, Nicola Polverelli, Francesca Palandri, Michele Baccarani, Nicola Vianelli, Roberto M. Lemoli
Journal: Blood (2011)
ATR Inhibition Exacerbates Replication Stress in TP53 or ATM Deficient CLL Cells and Enhances Sensitivity to Chemotherapy and Targeted Therapy
Authors: Marwan Kwok, Nicholas Davies, Angelo Agathanggelou, Edward Smith, Eva Petermann, Eliot Yates, Jeffrey Brown, Alan Lau, Tatjana Stankovic
Journal: Blood (2014)
Cardiac Safety of One Versus Four Hour Romidepsin (Istodax®) Infusion In the Setting of a Phase I/II Trial of Romidepsin, Dexamethasone and Bortezomib for Relapsed or Refractory Multiple Myeloma
Authors: Sam A Ruell, Miles Prince, Hang Quach, Emma Link, Joanne Dean, Simon J. Harrison
Journal: Blood (2010)
B-Lymphoid Transcription Factors Restrict Glycolytic Energy Supply for Oncogenic Signaling
Authors: Lai N Chan, Zhengshan Chen, Daniel Braas, Huimin Geng, Christian Hurtz, Seyedmehdi Shojaee, Valeria Cazzaniga, Carina Ng, Thomas Ernst, Andreas Hochhaus, Steven M Kornblau, Giovanni Cazzaniga, Grace Liu, Thomas Milne, H. Phillip Koeffler, Scott A. Armstrong, Ross Alexander Dickins, Keith R Yamamoto, Thomas G Graeber, Markus Muschen
Journal: Blood (2015)
Epoetin Alfa Reduces the Need for Red Blood Cell Transfusions and Does Not Affect Remission Rate or Survival When Given to Patients with Hematologic Malignancies Receiving Hyper-CVAD Therapy.
Authors: Gloria Mattiuzzi, Hagop Kantarjian, Maria Cabanillas, Maria Foudray, Rebecca Garris, Susan O’Brien, Deborah A. Thomas, Jorge Cortes
Journal: Blood (2008)
Detection of Relapse in Diffuse Large B-Cell Lymphoma (DLBCL) and Hodgkin’s Lymphoma (HL): Observations and Implications for Post-Remission Radiologic Surveillance.
Authors: Marin F. Xavier, Stephen J. Schuster, Charalambos Andreadis, Lisa Downs, Bernadette Diccion, Sunita Dwivedy Nasta
Journal: Blood (2006)
Serum and Extracellular Vesicle Micrornas MiR-423, MiR-199 and MiR-93* As Biomarkers for Acute Graft Versus Host Disease
Authors: Rachel E Crossland, Jean Norden, Kim F Pearce, Mateja Kralj Juric, Clare Lendrem, Louis A Bibby, Matthew Collin, Hildegard T. Greinix, Anne M Dickinson
Journal: Blood (2016)
Delayed heamatoma after melanoma metastasis resection upon restart of Immunotherapy: Case Report and Review of the Literature
Authors: Ali Elhag, José Lavrador, Joseph Frantzias, Ahilan Kailaya-Vasan, Richard Gullan, Prajwal Ghimire, Francesco Vergani, Keyoumars Ashkan, Ranjeev Bhangoo
Journal: Neuro-Oncology (2019)

Abstract Background Supratentorial Metastatic Melanomas are common and increasingly treated with immunotherapy. While improving the outcome, the immunotherapy potentially increases the risks of the intracranial surgical procedures, particularly bleeding. However, scarce reports address this complications. Case Description A 52-year old male with a history of right upper limb excised skin lesion resected with wide local excision 6 months prior to admission, who presented with a three weeks history of progressive headaches, vomiting, odd behaviours, forgetfulness, and left lower sided weakness. Brain imaging showed a right frontal lesion with evidence of haemorrhage within it with midline shift and mass effect. He underwent craniotomy and resection of the lesion with no post-operative complication, resolution of left sided hemiparesis and post-operative imaging documenting complete resection and no post-operative complications. The histopathology confirmed metastatic melanoma and he received adjuvant immunotherapy (Nivolumab), however he represented 4 weeks post operatively with sudden onset headache with vomiting with no neurological deficit, brain imaging showed a delayed hematoma in the surgical site. Conclusions This case report highlights the risk of post-operative bleeding with the immunotherapy and paves the way for further studies with regards to the safety of immunotherapy after intracranial procedures
The Ordered Expression of Transcription Factors Directs Hierarchical Lineage Specification of Eosinophils, Basophils and Mast Cells.
Authors: Hiromi Iwasaki, Yojiro Arinobu, Shin-ichi Mizuno, Hirokazu Shigematsu, Kiyoshi Takatsu, Daniel G. Tenen, Koichi Akashi
Journal: Blood (2004)
Assessment of IgA anti-PT and IgG anti-ACT reflex testing to improve Bordetella pertussis serodiagnosis in recently vaccinated subjects
Authors: L. Subissi, C. Rodeghiero, H. Martini, A. Litzroth, K. Huygen, G. Leroux-Roels, D. Piérard, I. Desombere
Journal: Clinical Microbiology and Infection (2019)
Acalabrutinib Monotherapy in Patients with Ibrutinib Intolerance: Results from the Phase 1/2 ACE-CL-001 Clinical Study
Authors: Farrukh T. Awan, Anna Schuh, Jennifer R. Brown, Richard R. Furman, John M. Pagel, Peter Hillmen, Deborah M. Stephens, Ahmed Hamdy, Jane Huang, Raquel Izumi, Priti Patel, Min Hui Wang, John C. Byrd
Journal: Blood (2016)
Benefit of Early Treatment with Room Temperature Stable Recombinant Activated Factor VII (rFVIIa) in Patients with Hemophilia a or B with Inhibitors: Subgroup Analysis from the Prospective, Post-Authorization, Non-Interventional SMART-7™ Study
Authors: Gary Benson, Hervé Chambost, Francesco Demartis, Soraya Benchikh El Fegoun, Katarina Cepo, Lene Sommer, Kaan Kavakli
Journal: Blood (2016)
Core Binding Factor Acute Myeloid Leukemia In Pediatric Patients Enrolled In The AIEOP AML 2002/01 Trial: The Impact Of Minimal Residual Disease On Patient Outcome
Authors: Martina Pigazzi, Valzerda Beqiri, Elena Manara, Roberto Rondelli, Riccardo Masetti, Carmelo Rizzari, Maria Caterina Putti, Andrea Pession, Franco Locatelli, Giuseppe Basso
Journal: Blood (2013)
Prognostic impact of circulating Epstein-Barr virus (EBV) DNA concentration and EBV serology in 125 extranodal NK/T cell lymphoma, nasal type (ENKL) patients
Authors: Chengcheng Guo, Huang He, Hongqiang Guo, Jian Xiao, Yujing Zhang, Ying Tian, Yabing Cao, Xiaohong Fu, Linzhu Zhai, Tongyu Lin
Journal: Blood (2010)
The Eµ-Myc/TCL1 Transgenic Mouse As a New Aggressive B-Cell Malignancy Model Suitable for Preclinical Therapeutics Testing
Authors: Kerry A. Rogers, Dalia El-Gamal, Harrington K. Bonnie, Hing A. Zachary, Goettl M. Virginia, Mantel Rose, Lisa L. Smith, Lianbo Yu, Amy J. Johnson, John C. Byrd, Rosa Lapalombella, Jennifer A. Woyach
Journal: Blood (2015)
Allogeneic Hematopoietic Stem-Cell Transplantation with Reduced-Intensity Conditioning in Patients with Refractory and Relapsing Multiple Myeloma: Long-Term Follow-up.
Authors: Avichai Shimoni, Izhar Hardan, Francis Ayuk, Georgia Schilling, Djordje Atanackovic, Wolfgang Zeller, Noga Shem-Tov, Avital Rand, Ronit Yerushalmi, Axel Zander, Nicolaus Kroger, Arnon Nagler
Journal: Blood (2009)
Reduced Intensity Conditioning Regimen in Single Unrelated Cord Blood Transplantation in Adults with Hematological Malignant Disorders. An Eurocord-Netcord and SFGM-TC Survey.
Authors: Vanderson Rocha, Bernard Rio, Federico Garnier, Marc Renaud, Anne Sirvent, Satoshi Takahashi, Didier Blaise, Eliane Gluckman
Journal: Blood (2006)
Nutritional Status and Hydroxyurea Use Among Children with Sickle Cell Disease in Malawi
Authors: Graham Ellis, Godwin Chipoka, Pilirani Mafunga, Jonathan Brett Heimlich, Tisungane Mvalo, Portia Kamthunzi, Isobel Kambalami, Kate Westmoreland, Toon van der Gronde, Peter Wasswa, Nigel S. Key, Kenneth I. Ataga, Mehdi Nouraie, Satish Gopal
Journal: Blood (2016)
Activated Protein C Inhibits Lipopolysaccharide-Induced Anandamide and 2-Arachidonoylglycerol Generation In Vitro and In Vivo.
Authors: Ikuro Maruyama, Yin Wang, Yan Liu, Koichi Kawahara, Munekazu Yamakuchi, Teruto Hashiguchi, Toru Obata
Journal: Blood (2007)
Minimal Residual Disease Studies in Multiple Myeloma Patients Achieving Complete Remission after Autologous Peripheral Blood Stem Cell Transplantation (APBSCT) by RQ-PCR.
Authors: M. E. Sarasquete, R. García-Sanz, A. Balanzategui, P. Martínez-Sánchez, J. Martínez-López, M. C. Chillón, D. González, J.J. Lahuerta, A. Armellini, P. Martín-Jiménez, M. Alcoceba, L. Blázquez, C. Fernández, M. González, J.F. San Miguel
Journal: Blood (2004)
Safety and Efficacy of Daratumumab with Lenalidomide and Dexamethasone in Relapsed or Relapsed, Refractory Multiple Myeloma
Authors: Torben Plesner, Hendrik-Tobias Arkenau, Henk M. Lokhorst, Peter Gimsing, Jakub Krejcik, Charlotte Lemech, Monique C. Minnema, Ulrik Lassen, Jacob P. Laubach, Tahamtan Ahmadi, Howard Yeh, Mary E Guckert, Huaibao Feng, Nikolai Constantin Brun, Steen Lisby, Linda Basse, Antonio Palumbo, Paul G. Richardson
Journal: Blood (2014)
Augmented Hyper-CVAD in Adult ALL Salvage Therapy: The MDACC Experience of Hyper-CVAD Using Dose-Intense Vincristine, Dexamethasone, and Pegaspargase.
Authors: Mohamad Ayoubi, Deborah A. Thomas, Hagop Kantarjian, Susan O'Brien, Farhad Ravandi, Guillermo Garcia-Manero, Srdan Verstovsek, Michael Rytting, Gautam Borthakur, Tapan Kadia, Steven M. Kornblau, Michael Andreeff, Jenny Feliu, Stefan Faderl
Journal: Blood (2009)
A Molecular Model for the Prediction of Progression Free Survival in Young Mantle Cell Lymphoma Patients Treated with Cytarabine-Based High Dose Sequential Chemotherapy and Autologous Stem Cell Transplantation: Results from the MCL0208 Phase III Trial from Fondazione Italiana Linfomi (FIL)
Authors: Davide Rossi, Simone Ferrero, Alessio Bruscaggin, Paola Ghione, Alice Di Rocco, Valeria Spina, Vittorio Stefoni, Giovannino Ciccone, Daniela Barbero, Luigia Monitillo, Maria Gomes Da Silva, Armando Santoro, Annalia Molinari, Andres J.M. Ferreri, Sergio Cortelazzo, Marco Ladetto, Gianluca Gaidano
Journal: Blood (2015)
Interaction between B-CLL Cells and Lymphoid Microenvironment Leads to Activation of PI3-K/Akt Pathway and Inhibition of Apoptosis.
Authors: Medhat Shehata, Susanne Schnabl, Dita Demirtas, Josef D. Schwarzmeier, Martin Hilgarth, Markus Duechler, Rainer Hubmann, Ulrich Jaeger
Journal: Blood (2005)
The Sesquiterpene Lactone Parthenolide Rapidly and Selectively Induces Apoptosis of B-Chronic Lymphocytic Leukemia Cells.
Authors: Andrew J. Steele, Anouska A. Casanova, A. Victor Hoffbrand, Atul B. Mehta, Kanagasabai Ganeshaguru, Dylan T. Jones, R. Gitendra Wickremasinghe
Journal: Blood (2004)
Inhibition of Multiple Myeloma Cells Growth by AS602868, a Pharmacological Inhibitor of IKK2.
Authors: Michel Jourdan, Jerome Moreaux, Dirk Hose, Jean-Francois Rossi, Karène Mahtouk, Mathieu Aboulaze, Nicolas Robert, Marion Baudard, Thierry Reme, Angela Romanelli, Hartmut Goldschmidt, Michel Dreano, Bernard Klein
Journal: Blood (2006)
D-index-guided early antifungal therapy for persistent FN in patients with hematological malignancies (CEDMIC trial)
Authors: Emiko Sakaida, Yoshinobu Kanda, Shun-Ichi Kimura, Masaki Iino, Takahiro Fukuda, Tatsuo Oyake, Hiroki Yamaguchi, Shin-Ichiro Fujiwara, Junji Suzumiya, Akinao Okamoto, Hiroyuki Fujita, Yasushi Takamatsu, Yoshio Saburi, Itaru Matsumura, Jun Yamanouchi, Souichi Shiratori, Moritaka Gotoh, Shingen Nakamura, Kazuo Tamura
Journal: Annals of Oncology (2019)
Clinical Significance of Mutations and Copy Number Lesions on Prognosis of Patients with MDS after Unrelated Bone Marrow Transplantation
Authors: Tetsuichi Yoshizato, Yoshiko Atsuta, Yusuke Shiozawa, Kenichi Yoshida, Yasuhito Nannya, Hiromichi Suzuki, Keitaro Matsuo, Makoto Onizuka, Keisuke Kataoka, Kenichi Chiba, Hiroko Tanaka, Yuichi Shiraishi, Kosuke Aoki, Masashi Sanada, Hidehiro Itonaga, Yoshinobu Kanda, Yasushi Miyazaki, Hideki Makishima, Satoru Miyano, Seishi Ogawa
Journal: Blood (2016)
Simulation of Clinical Outcome for Pomalidomide Plus Low-Dose Dexamethasone in Patients with Refractory Multiple Myeloma Based on Week 8 M-Protein Response
Authors: Rene Bruno, Fredrik Jonsson, Mohamed Zaki, Christian Jacques, Arlene S Swern, Paul G. Richardson, Vincent Rajkumar, Laurent Claret
Journal: Blood (2011)
Costs of Imatinib, Costs of Transplants and Gross National Income Per Capita Impact on Transplant Rates for Chronic Myeloid Leukemia in European Countries.
Authors: Alois Gratwohl, Helen Baldomero, Alvin Schwendener, Michael Gratwohl, Karl Frauendorfer, Alvaro Urbano-Ispizua
Journal: Blood (2006)
A Prospective Randomized Comparison of Idarubicin and High-Dose Daunorubicin in the Induction Chemotherapy for Acute Myeloid Leukemia
Authors: Je-Hwan Lee, Hawk Kim, Young-Don Joo, Won Sik Lee, Sung Hwa Bae, Dae Young Zang, Jihyun Kwon, Min Kyoung Kim, Junglim Lee, Gyeong Won Lee, Jung-Hee Lee, Yunsuk Choi, Dae-Young Kim, Sung-Nam Lim, Sang-Min Lee, Hun-Mo Ryoo, Hyo Jung Kim, Myung Soo Hyun, Kyoo-Hyung Lee
Journal: Blood (2015)
Immunogenicity of the Live Attenuated Varicella Vaccine Following Allogeneneic HCT.
Authors: Trudy N Small, Nancy A. Kernan, Susan E Prockop, Farid Boulad, Andromachi Scaradavou, Rachel Kobos, Heidi Abendroth, Anne Casson, Joanne Torok-Castanza, Catherine Copeland, Richard J O'Reilly
Journal: Blood (2009)
Risk Factors for Arterial Versus Venous Thrombosis in Polycythemia Vera: Single Center Experience in 587 Patients
Authors: Sonia Cerquozzi, Daniela Barraco, Terra L. Lasho, Christy Finke, Curtis A. Hanson, Rhett P. Ketterling, Animesh Pardanani, Naseema Gangat, Ayalew Tefferi
Journal: Blood (2016)
Primary results from Japanese phase I study of pembrolizumab plus chemotherapy as front-line therapy for advanced NSCLC
Authors: Takayasu Kurata, Kazuhiko Nakagawa, Miyako Satouchi, Takashi Seto, Takeshi Sawada, Shi Rong Han, Kazuo Noguchi, Takashi Shimamoto, Naoyuki Nogami
Journal: Annals of Oncology (2019)
Abstract 12338: Production of Plasminogen Activator Inhibitor-1 in Infarcted Lesion was Associated With Coronary Endothelial Vasomotor Dysfunction and Progressive Dysfunction of Left Ventricle in Patients With Acute Myocardial Infarction
Authors: Takuya Shimizu, Manabu Uematsu, Toru Yoshizaki, Jun-ei Obata, Takamitsu Nakamura, Yukio Saito, Kiyotaka Kugiyama
Journal: Circulation (2015)

Experimental studies showed that plasminogen activator inhibitor-1 (PAI-1) is abundantly expressed in the infarcted myocardium and that the increased PAI-1 expression causes an impairment of fibrinolysis in the coronary vascular beds and left ventricular (LV) adverse remodeling after acute myocardial infarction (AMI). However, little is known in humans. Thus, this study examined whether PAI-1 produced in the infarcted lesion may contribute to coronary endothelial dysfunction and LV dysfunction in patients with AMI. Methods: Plasma levels of PAI-1 activity and tissue-plasminogen activator (tPA) protein were measured by ELISA in plasma obtained from aortic root (AO), anterior interventricular vein (AIV), and peripheral vein (PV) in 41 patients with a first AMI due to occlusion of a proximal segment of the LAD at 6 months (M) after MI. Coronary blood flow responses in the LAD to intracoronary infusion of acetylcholine (ACh, 50 μg/min) were measured by an intracoronary flow wire technique 6M after MI. Left ventriculography was repeated twice, 2 weeks (2W) and 6M after MI. Results: The trans-myocardial gradient of PAI-1 from AO to AIV (0.14 ± 0.15 ng/mL), reflecting a production/release of PAI-1 from the infarcted lesion, had an inverse correlation with coronary blood flow response to ACh (r = -0.43 , p = 0.02). The trans-myocardial gradient of PAI-1 had an inverse correlation with the % changes in LV regional motion in the LAD territory from 2W to 6M after MI (r = -0.37, p = 0.02). PAI-1 level in the PV and the trans-myocardial gradient of tPA had no significant correlation with the coronary blood flow response to ACh and the LV regional motion. The trans-myocardial gradient in PAI-1 level was lower in patients taking than not taking angiotensin II receptor blocker (ARB) (n = 22, -0.15 ± 0.19 ng/mL vs. n = 19, 0.48 ± 0.21 ng/mL, respectively, p = 0.03). Conclusions: PAI-1 produced in the infarcted myocardium and released into the coronary circulation was associated with endothelial dysfunction in resistance vessels of the infarct-related coronary arteries and progressive dysfunction of the infarcted region of LV in AMI survivors. ARB might inhibit PAI-1 production in the infarcted myocardium in the chronic phase of MI, which may represent an additional benefit of ARB therapy.
Validation of the Revised International Prognostic Scoring System in 2582 Patients with Myelodysplastic Syndrome: A Multicenter Study By the Hellenic MDS Study Group
Authors: Athanasios Galanopoulos, Christos K. Kontos, Nora-Athina Viniou, Ioannis Kotsianidis, Vassiliki Pappa, Aleka Kourakli, Anastasia Pouli, Panayiotis Panayiotidis, Paraskevi Roussou, Kalliopi Zafeiropoulou, Stamatis Karakatsanis, Maria Dimou, Anna Vardi, Theodoros Vassilakopoulos, Dimitris Tsokanas, Eleftheria Hatzimichael, Aikaterini Megalakaki, Georgia D Kaiafa, Menelaos Konstantinos Papoutselis, Anastasia Sioni, Nikolaos Charchalakis, Eleni Bouronikou, George Vassilopoulos, Vasilios Lazaris, Maria Spiliotopoulou, Panagiotis Theodorou Diamantopoulos, Flora Kontopidou, Zoi Topouzoglou, Stamatina Kalyva, Helen A. Papadaki, Apostolos I Hatzitolios, Achilles Anagnostopoulos, Evangelos Briasoulis, Nikolaos I. Anagnostopoulos, Argiris S. Symeonidis
Journal: Blood (2016)
Diffuse Large B-Cell Lymphoma Patient-Derived Xenograft Models Capture Molecular and Biologic Heterogeneity and Inform Therapy
Authors: Bjoern Chapuy, Honwei Cheng, Akira Watahiki, Matthew D Ducar, Daniel Gusenleitner, Linfeng Chen, Margaretha GM Roemer, Jing Quyang, Amanda L Christie, Liye Zhang, Yuxiang Tan, Ryan P Abo, Frederike Bonin, Aaron R Thorner, Heather H. Sun, Geraldine S Pinkus, Paul van Hummelen, Gerald G Wulf, Jon C Aster, David M Weinstock, Stefano Monti, Scott J Rodig, Yuzhuo Wang, Margaret A. Shipp
Journal: Blood (2015)
Comprehensive Genomic Analysis Provides Further Evidence That Iron Overload Can Induce Genetic Instability in Myelodysplastic Syndromes
Authors: Gina Westhofen, Christina Ganster, Fabian Beier, Tienush Rassaf, Haifa Kathrin Al-Ali, Reingard Stuhlmann, Ulrike Bacher, Tim H. Brümmendorf, Ulrich Germing, Norbert Gattermann, Detlef Haase
Journal: Blood (2015)