tbuckley/cabot-search huggingface dataset:
AB1009 Concordance between vertebral fracture assessment and conventional radiography in detection of vertebral fracture
Authors: M. Brahem, N. ElAmri, K. Baccouch, S. Belghali, R. Mlayah, H. Zeglaoui, E. Bouajina
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Vertebral fractures (VFs) are considered as severe fractures, but often asymptomatic. The VFA (Vertebral Fracture Assessment) performed at the same time as the bone mineral density (BMD) measure, allows the detection of these fractures. Nevertheless, standard radiography remains the reference technique in the diagnosis of VFs. <h3>Objectives</h3> Our objective is to compare the contribution of VFA and the standard thoraco-lumbar spine X-ray in the diagnosis of FVs in patients at risk. <h3>Methods</h3> This is a cross sectional study, including women referred in rheumatology department for measure of bone mineral density (BMD). During the same exam, we practiced a vertebral fracture assessment (VFA) image. An X-Ray of dorsal and lumbar spine was done. The interpretation of the two methods was to diagnose asymptomatic vertebral fractures (VFs) which are defined according to Genant's semi-quantitative classification. <h3>Results</h3> The mean age of our patients (31 patients) was 61.3±11.3 years<sup>38–82</sup> with an average body mass index (BMI) of 27.65±4.8 Kg/m<sup>2</sup>; [17.8–40.1]. According to the WHO classification, 17 women (54.8%) had osteoporosis, 10 (32.3%) had osteopenia and 4 (12.9%) had normal BMD. The indications for VFA practice were: age over 60 years with T score≤−2 SD, historical height loss ≥4 cm, a history of VF, a long-term corticosteroid therapy, and aromatase inhibitors therapy in 25.8%, 12.9%, 6.5%, 45.2% and 9.7% respectively. VFA objectified 15 VFs in 6 women (19.4%) which were grade 1, 2 and 3 in respectively 2, 5 and 8 vertebras. However plain X ray showed 21 VFs in 10 women (32.2%) which were grade 1, 2 and 3 in respectively 5, 7 and 9 vertebras. The concordance between the two methods was found in 87.1% of cases, with a coefficient of Cohen (kappa) at 0.76 (strong agreement). A significant correlation (p=0.000) was found between the two methods concerning the detection of VFs grade II and III. <h3>Conclusions</h3> Our study proved the good agreement between the VFA and the standard X-ray in the detection of FVs. This shows the sensitivity of this technique which has the advantages of low cost and less irradiation. <h3>Disclosure of Interest</h3> None declared
Endothelial C-Type Natriuretic Peptide Is a Critical Regulator of Angiogenesis and Vascular Remodeling
Authors: Kristen J. Bubb, Aisah A. Aubdool, Amie J. Moyes, Sarah Lewis, Jonathan P. Drayton, Owen Tang, Vedanta Mehta, Ian C. Zachary, David J. Abraham, Janice Tsui, Adrian J. Hobbs
Journal: Circulation (2019)

Angiogenesis and vascular remodeling are complementary, innate responses to ischemic cardiovascular events, including peripheral artery disease and myocardial infarction, which restore tissue blood supply and oxygenation; the endothelium plays a critical function in these intrinsic protective processes. C-type natriuretic peptide (CNP) is a fundamental endothelial signaling species that coordinates vascular homeostasis. Herein, we sought to delineate a central role for CNP in angiogenesis and vascular remodeling in response to ischemia.The in vitro angiogenic capacity of CNP was examined in pulmonary microvascular endothelial cells and aortic rings isolated from wild-type, endothelium-specific CNP-/-, global natriuretic peptide receptor (NPR)-B-/- and NPR-C-/- animals, and human umbilical vein endothelial cells. These studies were complemented by in vivo investigation of neovascularization and vascular remodeling after ischemia or vessel injury, and CNP/NPR-C expression and localization in tissue from patients with peripheral artery disease.Clinical vascular ischemia is associated with reduced levels of CNP and its cognate NPR-C. Moreover, genetic or pharmacological inhibition of CNP and NPR-C, but not NPR-B, reduces the angiogenic potential of pulmonary microvascular endothelial cells, human umbilical vein endothelial cells, and isolated vessels ex vivo. Angiogenesis and remodeling are impaired in vivo in endothelium-specific CNP-/- and NPR-C-/-, but not NPR-B-/-, mice; the detrimental phenotype caused by genetic deletion of endothelial CNP, but not NPR-C, can be rescued by pharmacological administration of CNP. The proangiogenic effect of CNP/NPR-C is dependent on activation of Gi, ERK1/2, and phosphoinositide 3-kinase γ/Akt at a molecular level.These data define a central (patho)physiological role for CNP in angiogenesis and vascular remodeling in response to ischemia and provide the rationale for pharmacological activation of NPR-C as an innovative approach to treating peripheral artery disease and ischemic cardiovascular disorders.
Abstract 24043: Cytosolic RBFox1 in Cardiac Fibrosis Regulation
Authors: Chen GAO, Yun-Hua Esther Hsiao, Shuxun Ren, Xinshu (Grace) Xiao, Yi Xing, Yibin Wang
Journal: Circulation (2017)

RBFox1 is known to be an RNA splicing regulator with enriched expression in cardiac muscle. Loss of RBFox1 expression is a molecular hallmark associated with pathological hypertrophy and heart failure. However, much of our current knowledge about RBFox1 focuses on nuclear RBFox1 with a major impact on global alternative splicing changes in the diseased heart. Yet, RBFox1 gene also generates a cytosolic isoform through alternative splicing (RBFox1c), but the specific function of RBFox1c in heart has not been characterized. RBFox1c expression is significantly repressed in the mouse failing heart and hypertrophic cardiomyocytes. We performed RNA-seq combined with GO and IPA analysis to determine the impact of RBFox1c expression in culture. Among the genes suppressed specifically by RBFox1c but not the nucleus RBFox1 are groups of pro-inflammatory genes. Both Motif enrichment analysis and de novo motif discovery identified significant enrichment of RBFox1 binding motif in the 3’UTRs of the RBFox1c regulated genes. Using CLIP analysis followed by RT-PCR, we observed RBFox1c, but not nuclear RBFox1 specifically interacted with targeted inflammatory gene 3’UTR. In the cardiac specific RBFox1 knockout mice, enhanced cardiac fibrosis was observed following TAC, associated with elevated expression of RBFox1c dependent inflammatory genes. In contrast, cardiac specific expression of RBFox1c significantly reduced cardiac fibrosis and inflammatory gene expression following TAC, associated with improved ejection fraction and reduced hypertrophic marker gene expression. Further, we tested the effect of RBFox1c expression on cardiac fibrosis response using NRVM conditioned media. We showed the conditioned media from the hypertrophic cardiomyocytes potently induce fibroblast proliferation. However, RBFox1c expression can suppress phenylephrine and isoproterenol induced fibroblasts proliferation. RBFox1 regulates cardiac transcriptome reprogramming at two post-transcriptional steps. The RBFox1 nuclei isoform regulates global RNA splicing reprogramming in heart, while the RBFox1c regulates inflammatory gene expression and fibrotic remodeling potentially through potential interaction with their 3’UTR and targeted RNA degradation.
SP0046 What we need to consider in physician-patient communication on sexual problems in different rheumatic conditions
Authors: M. Ostensen
Journal: Annals of the Rheumatic Diseases (2018)

<h3></h3> Quality of life (QOL) is often reduced in patients with chronic diseases. Sexual activity and enjoyment constitute an important aspect of QOL. Sexuality is a neglected area of QOL in patients with rheumatic disease. Sexual problems among patients are common and often increase with disease duration. Both disease related factors and the psychological response to chronic disease can impair sexual functioning. General disease symptoms like pain, fatigue, disease activity, and impaired physical function contribute to reduced sexual activity in both genders. However, psychological factors like depression, anxiety, negative body image and low self-esteem play an important role. Sexual dysfunction can create frustration and distress, and if chronic increase anxiety and depression, and damage interpersonal relationships. Sexual health is rarely addressed by health professionals (HP), and it is as a rule not spontaneously reported by patients. HPs may feel awkward to intrude into the intimate sphere of a patient, and patients may feel ashamed of revealing their sexual dysfunction. A first step to improve the physician-patient communication in this area is to include sexuality in the curriculum of health professionals teaching how to address and evaluate sexual function. Assessment of sexual function by validated instruments includes both frequency of intercourse as well as sexual desire, arousal, orgasm, and sexual satisfaction. In women vaginal lubrication and in men erectile function and ejaculation are part of the evaluation. Assessment of disease activity and comorbidities helps to detect physical components of sexual dysfunction. Barriers regarding communication on sexual activity should be identified and overcome. Assessment of sexual function may be assigned to a specially trained nurse, an occupational therapist or a psychologist of the interdisciplinary team. Referral to specialists in urology, gynaecology or sexual medicine may also help patients to get a better sex life. A major point for restoring sexual and reproductive health in patients of both genders is to achieve optimal disease control. <h3>Reference</h3> [1] Østensen M. Sexual and reproductive health in rheumatic disease. Nat Rev Rheumatol2017;13(8):485–493. <h3>Disclosure of Interest</h3> None declared
Management of out-of-hospital cardiac arrest with laryngeal tube improved survival vs endotracheal intubation
Authors: Michelle Welsford
Journal: Annals of Internal Medicine (2019)

Source Citation Wang HE, Schmicker RH, Daya MR, et al. Effect of a strategy of initial laryngeal tube insertion vs endotracheal intubation on 72-hour survival in adults with out-of-hospital cardiac arrest: a randomized clinical trial. JAMA. 2018;320:769-78. 30167699
Of the need to reconcile discrepancies between two different reference equations for combined single-breath <i>D</i><sub>LNO</sub>–<i>D</i><sub>LCO</sub> in systemic sclerosis
Authors: Thomas Radtke, Thông Hua-Huy, Holger Dressel, Anh Tuan Dinh-Xuan
Journal: European Respiratory Journal (2019)

<b>This study confirms clinically relevant differences between reference equations for nitric oxide pulmonary diffusing capacity (<i>D</i></b><sub><b>LNO</b></sub><b>) in systemic sclerosis. Future work on <i>D</i></b><sub><b>LNO</b></sub><b>reference equations is required to improve the validity of <i>D</i></b><sub><b>LNO</b></sub><b>outcomes.</b>http://ow.ly/NnA030nx1vG
Notes from the Field: Emergence of New Norovirus Strain GII.4 Sydney—United States, 2012
Journal: JAMA (2013)

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5-Azacytidine Induces NOXA and PUMA Expression to Prime AML Cells for Venetoclax-Mediated Apoptosis
Authors: Dan Cojocari, Sha Jin, Julie J Purkal, Relja Popovic, Nari N Talaty, Yu Xiao, Larry R Solomon, Erwin Boghaert, Joel D. Leverson, Darren C. Phillips
Journal: Blood (2018)
SAT0472 Ulnar occlusion is a marker of global vascular damage in systemic sclerosis: results from a monocentric prospective study of 99 patients
Authors: C.M. Yelnik, D. Elodie, C. Lamotte, V. Sobanski, S. Morell-Dubois, H. Maillard, M. Lambert, P.-Y. Hatron, D. Launay, E. Hachulla
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Macrovascular damages of systemic sclerosis (SSc) were poorly investigated, and the link between macrovasculopathy and microvasculopathy of SSc, cardiovascular disease, and mortality remain unclear. <h3>Objectives</h3> To evaluate if macrovascular damage in SSc predicts the occurrence of new digital ulcers (DU), cardiovascular events and mortality, and to further assess the relationship between micro and macrovascular damages in SSc. <h3>Methods</h3> All consecutive SSc patients followed in our SSc National Reference Centre, who underwent an arterial doppler ultrasonography (aDUS) of the upper limbs, were included and prospectively followed up until October 2017. Inclusion criteria were: 1) adults; 2) a diagnosis of <sup>SSc according to 2013</sup> ACR/EULAR criteria; 3) aDUS performed in our vascular exploration department. <h3>Results</h3> Ninety-nine SSc patients were included. Median follow-up duration was 35 (IQR, 21 to 39) months. Macrovascular damages mainly affected ulnar arteries, with ulnar artery occlusion (UAO) in 28 (28.3%) patients (bilateral 60.7%). New DU occurred in 26 (27.1%) patients, new cardiovascular event in 10 (10.4%) patients, and 11 patients died during the study period. Interestingly, UAO was not associated with traditional cardiovascular risk factors (except dyslipidemia) nor with history of cardiovascular diseases, and was not predictive of new cardiovascular events. Conversely, UAO was associated with makers of microvascular damages, such as late nailfold capillaroscopy pattern (33.3% vs 6.8%; OR=6.88, 95% CI=1.76 to 26.82; p=0.03) and was predictive of new ischaemic DU (44.5% vs 24.8%; HR=2.23, 95%CI=1.02 to 4.86; p=0.037), pleading for a SSc specific vasculopathy. <h3>Conclusions</h3> Our study confirms that macrovascular damages are frequent in SSc patients and mainly affect ulnar arteries. Interestingly, UAO was associated with severe microvasculopathy, but not with markers of cardiovascular diseases. <h3>Disclosure of Interest</h3> None declared
THU0012 Targeted re-sequencing of 128 rheumatoid arthritis susceptibility genes uncovers novel risk loci in the singapore chinese population
Authors: J.M.Y. Yong, L.L. Goh, C.W. Lim, P.P.Q. Lim, G. L.-X. Toh, E.T. Koh, K.P. Leong
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Rheumatoid arthritis (RA) is a fairly common inflammatory autoimmune disease with a prevalence of 1% to 1.5%. Patients experience chroic joint pain, swelling and overtime irreversible joint damage. Genetic variants known to contribute to rheumatoid arthritis (RA) susceptibility have been reported in more than 120 genes, including the HLA, PTPN22, CTLA4, TNFAIP3, PADI4, FCRL3, CD4, CD244 and CD40. The genetic susceptibility to RA has not been studied in the Singapore population. <h3>Objectives</h3> To identify novel risk variants in candidate genes previousy reported to be associated with rheumatoid arthritis (RA) in Singapore Chinese RA patients positive for anti-citrullinated peptide antibodies (ACPA). <h3>Methods</h3> All the 128 known candidate genes associated with RA identified through GWAS were sequenced in 48 RA patients and 45 controls. The resultant data was analysed for association using single variant association and pathway-based association enrichment tests. In addition, the genetic burden due to rare variants was assessed using the C-alpha test. The candidate variants that showed significant association were validated in a larger cohort of 500 RA cases and 500 controls using mass array and Taqman technologies. <h3>Results</h3> 39 variants in 18 genes were identified using single variant association analysis and C-alpha test. IL6ST, with stepwise filtering. Among these, the missense variant in IL6ST, 5:55260065 (p.Cys47Phe) was significantly associated with RA in the Singapore Chinese patients (p=0.0194). The insignificant results of additional potential rare variants such as IL6ST, 5:55237103 and PXK rs199881366 is highly due to the limitations of our small sample size. <h3>Conclusions</h3> Our results suggest that IL6ST, 5:55260065, 5:55237103 and PXK rs199881366 confer risk of RA in ACPA-positive Chinese patients. <h3>Disclosure of Interest</h3> None declared
Abstract P282: Potato Consumption, Average Blood Pressure, and the Incidence of Hypertension in 2 Mediterranean Cohorts
Authors: Emily A Hu, Miguel A Martínez-González, Jordi Salas-Salvadó, Dolores Corella, Emilio Ros, Montse Fitó, Enrique Gomez-Gracia, Ramon Estruch, Fernando Arós, Miquel Fiol, José Lapetra, Lluís Serra-Majem, Xavier Pintó, Miguel Ruiz-Canela, Cristina Razquin, Monica Bullo, Jose V Sorlí, Helmut Schröder, Casey Rebholz, Estefania Toledo
Journal: Circulation (2017)

Objectives: To assess the association between potato consumption, blood pressure changes and the risk of hypertension in two Mediterranean populations. Design: Separate analyses were performed in the PREDIMED (PREvención con DIeta MEDiterránea), a multicenter nutrition intervention trial, and the SUN (“Seguimiento Universidad de Navarra”) project, an open, prospective cohort, both in Spain. Participants: The PREDIMED trial included 6,940 participants aged 55-80 years at high risk for cardiovascular disease. The SUN project included 13,837 middle-aged participants who were university graduates. Main outcome measures: In PREDIMED, generalized estimating equations adjusted for lifestyle and dietary characteristics were used to assess changes in blood pressure across quintiles of total potato consumption during a 4-year follow-up. Controlled blood pressure levels during follow-up were also assessed. For SUN, multivariable-adjusted hazard ratios (HR) for incident hypertension during an average 6.7-year follow-up were calculated. Results: In PREDIMED, the mean (SD) total potato intake was 81.9 (40.6) g/day. No overall significant differences in blood pressure changes were detected based on consumption of potatoes. For total potatoes, the mean change in systolic BP after multivariate adjustment was quintile 5 (Q5) vs. quintile 1 (Q1): -0.90, 95% CI: (-2.56 to 0.76) mmHg, p for trend=0.14 and for diastolic BP it was Q5 vs. Q1: -0.02, 95% CI: (-0.93 to 0.89) mmHg, p for trend=0.81. In SUN, the mean (SD) total potato consumption was 52.7 (33.6) g/day and no significant association between potato consumption and hypertension incidence was observed: HR: for total potato consumption, Q5 vs. Q1: 0.98, 95% CI: (0.80 to 1.19), p for trend=0.84. Conclusions: Potato consumption is not associated with changes in blood pressure or risk of hypertension in Mediterranean populations and this might be explained by relatively low consumption of potatoes and characteristics of the traditional Mediterranean diet, particularly the custom of accompanying potatoes with vegetables or legumes and dressing them with olive oil.
Abstract 16970: S100A6 Interacts With Melusin and Attenuates Stress-Induced Cardiomyocyte Apoptosis
Authors: James N Tsoporis, Shehla Izhar, Jean Francois Desjardins, Howard Leong-Poi, Thomas G Parker
Journal: Circulation (2017)

Introduction: Cardiac overexpression of S100A6, a member of the family of EF-hand calcium binding proteins attenuates left ventricular remodeling and preserves cardiac function after myocardial inf...
Severity of disease and quality of life in parents of children with alopecia areata, totalis, and universalis: A prospective, cross-sectional study
Authors: Elana Putterman, Deepa P. Patel, Gabriela Andrade, Katya L. Harfmann, Marcia Hogeling, Carol E. Cheng, Carolyn Goh, Rachel S. Rogers, Leslie Castelo-Soccio
Journal: Journal of the American Academy of Dermatology (2019)
Melanoma and melanoma in-situ diagnosis after excision of atypical intraepidermal melanocytic proliferation: A retrospective cross-sectional analysis
Authors: Nina R. Blank, Brian P. Hibler, Ian W. Tattersall, Courtney J. Ensslin, Erica H. Lee, Stephen W. Dusza, Kishwer S. Nehal, Klaus J. Busam, Anthony M. Rossi
Journal: Journal of the American Academy of Dermatology (2019)
AB0764 Comparison of disease characteristics in patients with juvenile-onset and adult-onset progressive systemic sclerosis
Authors: G. Karatemiz, A. Androvic, S.N. Esatoglu, S. Sahin, K. Barut, G. Hatemi, V. Hamuryudan, O. Kasapcopur, E. Seyahi
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Progressive systemic sclerosis (PSSc) has been known to affect mainly adults of 30–50 years of age. Juvenile –onset has been reported to be rare and studies comparing clinical differences between juvenile-onset and adult onset form have been limited.<sup>1</sup> These studies were coming from European and North American countries.<sup>1–2</sup> As there would be also effects of ethnic differences, we aimed to assess clinical differences between the two forms of pSSc of paediatric and adult rheumatology centres of a tertiary centre, in Turkey. <h3>Methods</h3> Adult onset patients were defined as those who were registered and followed as 'scleroderma' at the departments of adult and paediatric rheumatology at Cerrahpasa Medical Faculty, Istanbul, between 2005 and 2017. Only those with at least 2 follow-up visits were included. Patients's charts were re-evaluated retrospectively. <h3>Results</h3> There were 140 patients with scleroderma in the adult outpatient clinic records and 51 in the paediatric clinic records. Of these patients, 3 (2%) adults and 25 (49%) paediatric patients had localised scleroderma (p&lt;0.001). We studied the remaining patients (adults: n=137, juvenile: n=26) who had systemic pattern. Male/female ratio, median follow-up duration, familial history of chronic inflammatory diseases and the frequency of sclerodactyly, digital ulcers, Raynaud phenomenon, arrhythmia/heart failure and gastrointestinal involvement were similar between two groups (table 1). The frequency of interstitial lung disease, pulmonary artery hypertension, and serum ANA positivity were significantly more common in the adult onset group. Whereas joint and muscle involvements were significantly more common among juvenile onset patients. DMARD use was significantly more common in the juvenile group while the use of vasodilators was more frequent among adults1 <h3>Conclusions</h3> Our results are online with previous reports: juvenile onset patients seem to have a milder form of disease. Major organ involvement as defined interstitial lung disease and pulmonary artery hypertension was more common among adult onset patients. On the other hand, as expected, joint involvement and myopathy were major causes of morbidity in the juvenile group. Contrary to that previously reported, cardiac involvement was not common in the juvenile group. <h3>References</h3> [1] Scalapino K, J Rheumatol. 2006. [2] Ingegnoli F, Microvasc Res. 2015. <h3>Disclosure of Interest</h3> None declared
Association of Hemodynamic Severity With Plaque Vulnerability and Complexity of Coronary Artery Stenosis
Authors: Yoshiki Matsuo, Daisuke Higashioka, Yasushi Ino, Yasutsugu Shiono, Hironori Kitabata, Kosei Terada, Hiroki Emori, Yosuke Katayama, Akira Taruya, Tsuyoshi Nishiguchi, Kunihiro Shimamura, Takeyoshi Kameyama, Akio Kuroi, Takashi Yamano, Takashi Tanimoto, Atsushi Tanaka, Takeshi Hozumi, Takashi Kubo, Takashi Akasaka
Journal: JACC. Cardiovascular imaging (2019)