tbuckley/cabot-search huggingface dataset:
Growth inhibitory effects of naphthoquinones type compounds in human origin cancer cell line
Authors: Harukuni Tokuda, Takafumi Kaneko, Akira Iida
Journal: Cancer Research (2008)

5470  Tabebuia avellanedae(Bignoniaceae)(TA), which is native in South America from Brazil to northern Argentina, is wellknown in traditionalfolk medicne used for the treatment of various disease during five hundred years. The inner bark of this plant produced in Brazil is distributed in Asia as a herb tea and healthy purpose. Previously, we reported that extract essense of TA(TA ess.) and including naphthoquinones type active compounds, lapachol, beta-lapachone and NFD inhibited TPA-induced in vitro assay for anti-tumor promoters and also suppressed the generation of superoxide and nitric oxide by convenient assay method. In this study, the purpose of other potency of these useful samples was to develop new active effect, cytotoxic function as an effective cancer chemosensitivity test, Effects of lapachol, beta-lapachone and NFD on cancer cells growth was investigated using three cell line, A549, PC-3 and MCF-7 which are human derived organ cell line. Physiological concentration of TA ess. had weak growth inhibitory effect in three cell lines, when cells were treated with 0.05 mM for 72 h. In contrast,lapachol and NFD had significantly inhibited dose-dependentin same cell line after 72 h incubation. Western blot analysis for MAPK signaling pathway showed apparent reduction of p38 and MEK in MCF-7 and A549 cell treated with NFD, but PC-3 observed no changes of these selected protein levels through sequential steps. These results suggested that growth inhibitory effects of cancer cell by natural isolated compounds might be related to the induction of MAPK pathway, and these naturally occurring substances might be a potential candidate for further developing  chemopreventive agent.
AB1063 CASE SERIES OF PATIENTS WITH CHRONIC NON-TUBERCULOSIS MYCOBACTERIA ACCOMPANYING WITH ANTI-INTERFERON GAMMA ANTIBODY
Authors: Y. P. Tsao
Journal: Annals of the Rheumatic Diseases (2020)

Background: Anti-interferon (IFN) gamma antibody was a rare autoantibody which mainly been reported in Asia. It interferes the interferon pathway and eradication of intracellular pathogens, such as Salmonella or Mycobacteria. This rare disease should be raised for more awareness. Objectives: To analyze clinical presentations of the patients with anti-interferon (IFN) gamma antibody. Methods: We checked anti-IFN gamma antibody when patient fulfilled multiple NTM infection (especially bone marrow and lymph nodes). There are 6 cases of non-tuberculosis mycobacteria (NTM) infection accompanying with anti-IFN gamma antibody in our hospital from 2015 to 2019 of hospitalist ward, and the antibody titer is recorded. Results: Among these cases, patients had initial presentations of fever (100%), elevated CRP and ESR (100%), lymphadenopathy (67%), body weight loss (50%), and elevated LDH (50%). All the 6 cases had negative results of TB-PCR test, but 1 had positive result of interferon gamma release assay (IGRA, 17%). NTM was identified from lymph node biopsy (50%), sputum (33%), skin (33%), and bone marrow (33%). Different NTM was identified, including Mycobacterium abscessus, Mycobacterium fortuitum group complex, Mycobacterium kanasii, and Mycobacterium avium complex. Prolonged antibiotics treatment was used, but all patients had recurrent or persisted NTM infection under medications. 4 cases had different NTM strain after 1 year of treatment from the initial involved organ. One case had an episode of Salmonella bacteremia with septic shock. Another case had positive result of ANA, and other cases had negative auto-antibodies. Conclusion: Careful history taking and physical examinations are crucial in diagnosis this acquired immunodeficiency disease. This rare but unique disease should be taken into consideration. Disclosure of Interests: None declared
Correction: <i>In Vivo</i> E2F Reporting Reveals Efficacious Schedules of MEK1/2–CDK4/6 Targeting and mTOR–S6 Resistance Mechanisms
Authors: Jessica L.F. Teh, Phil F. Cheng, Timothy J. Purwin, Neda Nikbakht, Prem Patel, Inna Chervoneva, Adam Ertel, Paolo M. Fortina, Ines Kleiber, Kim HooKim, Michael A. Davies, Lawrence N. Kwong, Mitch P. Levesque, Reinhard Dummer, Andrew E. Aplin
Journal: Cancer Discovery (2018)

In the original version of this article (1), an error in Fig. 6C was introduced by the compositor during the production of the paper. Specifically, the Raptor Western blot was improperly shifted. The figure has been corrected in the latest online HTML and PDF versions of the article. The publisher regrets the error.
FRI0370 DUAL OXIDASE MATURATION FACTOR 1 POSITIVELY REGULATES RANKL-INDUCED OSTEOCLASTOGENESIS VIA ACTIVATING REACTIVE OXYGEN SPECIES PRODUCTION AND TRAF6-MEDIATED SIGNALING
Authors: C. H. Lee, C. H. Chung, Y. J. Choi, W. H. Yoo, J. Y. Kim, M. S. Lee
Journal: Annals of the Rheumatic Diseases (2020)

Background: Reactive oxygen species (ROS) are one of the significant factors of chemical or physical cell signaling in a wide variety of cell types including skeletal cells. Receptor activator of NF-βB ligand (RANKL) induces generation of intracellular ROS, which act as second messengers in RANKL-mediated osteoclastogenesis. Dual oxidase maturation factor 1 (Duoxa1) was first identified as a Drosophila Numb-interacting protein (NIP), and has been associated with the maturation of ROS generating enzymes including dual oxidases (Duox1 and Duox2). In the progression of osteoclast differentiation using mouse bone marrow-derived macrophages (BMMs), we identified that only Duoxa1 level showed an effective change upon RANKL stimulation, but not Duox1, Duox2, and Duoxa2. Objectives: we hypothesized that Duoxa1 could independently act as a second messenger for RANKL stimulation and regulate ROS production during osteoclast differentiation. Methods: Using siRNA or retrovirus transduction and knockdown of Duoxa1 via siRNA Results: Duoxa1 level gradually increased during RANKL-induced osteoclast differentiation. We found that Duoxa1 regulated RANKL-stimulated osteoclast formation and bone resorption positively. knockdown of Duoxa1 via siRNA decreased the RANKL-induced ROS production. During Duoxa1-related control of osteoclastogenesis, activation of tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6)-mediated early signaling molecules including MAPKs, Akt, IβB, Btk, and PLC 2 was affected, which sequentially modified the mRNA or protein expression levels of key transcription factors in osteoclastogenesis, such as c-Fos and NFATc1, as well as mRNA expression of osteoclast-specific markers including OSCAR, ATP6v0d2, and CtsK. Conclusion: Overall, our data indicate that Duoxa1 plays a crucial role in osteoclastogenesis via regulating RANKL-induced intracellular ROS production and activating TRAF6-mediated signaling. Disclosure of Interests: None declared
The Moral Determinants of Health
Authors: Donald M. Berwick
Journal: JAMA (2020)

The Moral Determinants of HealthThe source of what the philosopher Immanuel Kant called "the moral law within" may be mysterious, but its role in the social order is not.In any nation short of dictatorship some form of moral compact, implicit or explicit, should be the basis of a just society.Without a common sense of what is "right," groups fracture and the fragments wander.Science and knowledge can guide action; they do not cause action.No scientific doubt exists that, mostly, circumstances outside health care nurture or impair health.Except for a few clinical preventive services, most hospitals and physician offices are repair shops, trying to correct the damage of causes collectively denoted "social determinants of health."Marmot 1 has summarized these in 6 categories: conditions of birth and early childhood, education, work, the social circumstances of elders, a collection of elements of community resilience (such as transportation, housing, security, and a sense of community self-efficacy), and, cross-cutting all, what he calls "fairness," which generally amounts to a sufficient redistribution of wealth and income to ensure social and economic security and basic equity.Galea 2 has cataloged social determinants at a somewhat finer grain, calling out, for example, gun violence, loneliness, environmental toxins, and a dozen more causes.
Genomic Correlates of Outcome in Tumor-Infiltrating Lymphocyte Therapy for Metastatic Melanoma
Authors: Caitlin A. Creasy, Yuzhong Jeff Meng, Marie-Andrée Forget, Tatiana Karpinets, Katarzyna Tomczak, Chip Stewart, Carlos A. Torres-Cabala, Shari Pilon-Thomas, Amod A. Sarnaik, James J. Mulé, Levi Garraway, Matias Bustos, Jianhua Zhang, Sapna P. Patel, Adi Diab, Isabella C. Glitza, Cassian Yee, Hussein Tawbi, Michael K. Wong, Jennifer McQuade, Dave S.B. Hoon, Michael A. Davies, Patrick Hwu, Rodabe N. Amaria, Cara Haymaker, Rameen Beroukhim, Chantale Bernatchez
Journal: Clinical Cancer Research (2022)

Abstract Purpose: Adoptive cell therapy (ACT) of tumor-infiltrating lymphocytes (TIL) historically yields a 40%–50% response rate in metastatic melanoma. However, the determinants of outcome are largely unknown. Experimental Design: We investigated tumor-based genomic correlates of overall survival (OS), progression-free survival (PFS), and response to therapy by interrogating tumor samples initially collected to generate TIL infusion products. Results: Whole-exome sequencing (WES) data from 64 samples indicated a positive correlation between neoantigen load and OS, but not PFS or response to therapy. RNA sequencing analysis of 34 samples showed that expression of PDE1C, RTKN2, and NGFR was enriched in responders who had improved PFS and OS. In contrast, the expression of ELFN1 was enriched in patients with unfavorable response, poor PFS and OS, whereas enhanced methylation of ELFN1 was observed in patients with favorable outcomes. Expression of ELFN1, NGFR, and PDE1C was mainly found in cancer-associated fibroblasts and endothelial cells in tumor tissues across different cancer types in publicly available single-cell RNA sequencing datasets, suggesting a role for elements of the tumor microenvironment in defining the outcome of TIL therapy. Conclusions: Our findings suggest that transcriptional features of melanomas correlate with outcomes after TIL therapy and may provide candidates to guide patient selection.
2020—A Year That Will Be Remembered
Authors: Howard Bauchner
Journal: JAMA (2020)

may be a transformative year of the 21st century.Like 1776, 1865, 1941, 1963, 1968, and 2001, it is a year that will be written about, taught in school, and become part of the collective memory of the people who lived through it.A pandemic, massive unemployment, unmeasurable morbidity yet to be realized, 55 million children out of school, mayors and governors making major health care decisions, and nationwide protests focused on the unrelenting and unremitting pain of racism have already occurred.2020 has the potential to be a transformative year, one leading to fundamental change in the fabric of society-only time will tell. 1,2AMA is committed "To promote the science and art of medicine and the betterment of the public health."That mission statement is meant to imply that journal content should include science and opinion of issues affecting human health.Translational research, clinical trials, observational cohort studies, and clinical reviews, as well as narrative medicine, the arts and sciences, and opinion fill the pages of JAMA every week.
Abstract 12826: Impact of a Nurse-Led Limited Risk Factor Modification Program on Arrhythmia Outcomes in Patients With Atrial Fibrillation Undergoing Catheter Ablation
Authors: Amaryah Yaeger, Brendan T Keenan, Nancy R Cash, Tara Parham, David S Frankel, Rajat Deo, Robert D Schaller, Pasquale Santangeli, Saman Nazarian, Gregory E Supple, Jeffrey Arkles, Ramanan Kumareswaran, Matthew C Hyman, Michael P Riley, Fermin C Garcia, David Lin, Andrew E Epstein, David J Callans, Francis E Marchlinski, Jorge I Mora, Anastassia Amaro, Richard Schwab, Allan Pack, Sanjay Dixit
Journal: Circulation (2019)

Introduction: We have demonstrated the efficacy of a nurse-led limited risk factor modification (RFM) program in improving weight loss and obstructive sleep apnea (OSA) care among atrial fibrillati...
JAK/STAT pathway inhibition sensitizes CD8 T cells to dexamethasone-induced apoptosis in hyperinflammation
Authors: Lauren K. Meyer, Katherine C. Verbist, Sabrin Albeituni, Brooks P. Scull, Rachel C. Bassett, Alexa N. Stroh, Heather Tillman, Carl E. Allen, Michelle L. Hermiston, Kim E. Nichols
Journal: Blood (2020)
SF‐6Dv2 preference value set for health utility in food allergy
Authors: Élise Dufresne, Thomas G. Poder, Kathryn Samaan, Jonathan Lacombe‐Barrios, Louis Paradis, Anne Des Roches, Philippe Bégin
Journal: Allergy (2020)

The lack of a value set allowing the calculation of QALY is an important limitation when establishing the value of emerging therapies to treat food allergy. The aim of this study was to develop a Short-Form Six-Dimension version 2 (SF-6Dv2) preference value set for the calculation of health utility from the Canadian food-allergic population.Two hundred ninety-five parents of patients aged 0-17 years old and 154 patients aged 12 years old and above with food allergy were recruited in clinic and online. Participants were asked to complete a self-administered online questionnaire including generic health-related quality of life questionnaires. Various health states described by the SF-6Dv2 were valued with time-trade-off and discrete choice experiments. Data from elicitation techniques were combined using the hybrid regression model.A total of 241 parents and 125 patients performed 3904 time-trade-off and 5112 discrete choice experiments. Utility decrements were estimated for each level of each SF-6Dv2 dimension. Utility values calculated based on the validated preference set were in average 0.15 lower (95%CI: 0.12-0.18) and were poorly correlated (R2 = 0.46) with those derived from the EQ-5D-5L generic questionnaire in the same cohort.A representative preference value set for patients with food allergy was determined using the SF-6Dv2 generic questionnaire. This adapted preference set will contribute to improve the validity of future utility estimates in this population for the appraisal of upcoming potentially impactful but sometimes costly therapies.
Annals Graphic Medicine - Comparing Resident Noon Conference Attendance by Quality of Speaker Versus Quality of Food
Authors: Matthew S. Krantz
Journal: Annals of Internal Medicine (2020)

Web Exclusives16 June 2020Annals Graphic Medicine - Comparing Resident Noon Conference Attendance by Quality of Speaker Versus Quality of FoodFREEMatthew S. Krantz, MDMatthew S. Krantz, MDVanderbilt University Medical Center, Nashville, Tennessee (M.S.K.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/G19-0071 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Download figure Download PowerPoint Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: Vanderbilt University Medical Center, Nashville, Tennessee (M.S.K.)Disclosures: The author has disclosed no conflicts of interest. The form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=G19-0071.Author/Illustrator Information: Matthew S. Krantz, MD, is a fourth-year resident in internal medicine and pediatrics at Vanderbilt University in Nashville, Tennessee, and a graduate of UNC School of Medicine in Chapel Hill, North Carolina. You can view more of his work on Instagram (www.instagram.com/matt_krantz). PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 16 June 2020Volume 172, Issue 12Page: W155-W156KeywordsConflicts of interestDisclosureFoodGraduate medical educationHealth carePediatrics ePublished: 16 June 2020 Issue Published: 16 June 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Plasticity and Spontaneous Activity Pulses in Disused Human Brain Circuits
Authors: Dillan J. Newbold, Timothy O. Laumann, Catherine R. Hoyt, Jacqueline M. Hampton, David F. Montez, Ryan V. Raut, Mario Ortega, Anish Mitra, Ashley N. Nielsen, Derek B. Miller, Babatunde Adeyemo, Annie L. Nguyen, Kristen M. Scheidter, Aaron B. Tanenbaum, Andrew N. Van, Scott Marek, Bradley L. Schlaggar, Alexandre R. Carter, Deanna J. Greene, Evan M. Gordon, Marcus E. Raichle, Steven E. Petersen, Abraham Z. Snyder, Nico U.F. Dosenbach
Journal: Neuron (2020)
残存腫瘍の大きさ及びIGCCCGリスク分類法は,胚細胞腫瘍と残存腫瘍切除を有する患者において,追加の血管手術の要否を予測する:ドイツの精巣癌研究群の複数センターでの分析 | 文献情報 | J-GLOBAL 科学技術総合リンクセンター
Authors: Winter Christian, Bingoel Cigdem, Albers Peter, Pfister David, Heidenreich Axel, Busch Jonas, Ranft Ulrich, Schrader Mark, Dieckmann Klaus-Peter
Journal: European Urology (2012)
Ahr-Foxp3-RORγt axis controls gut homing of CD4 <sup>+</sup> T cells by regulating GPR15
Authors: Lifeng Xiong, Joseph W. Dean, Zheng Fu, Kristen N. Oliff, John W. Bostick, Jian Ye, Zongming E. Chen, Marcus Mühlbauer, Liang Zhou
Journal: Science Immunology (2020)

GPR15 expression is promoted by Ahr in an evolutionarily conserved manner via cooperation with Foxp3 but inhibited by RORγt.
Recommendations for head and neck surgical oncology practice in a setting of acute severe resource constraint during the COVID-19 pandemic: an international consensus
Authors: Hisham Mehanna, John C Hardman, Jared A Shenson, Ahmad K Abou-Foul, Michael C Topf, Mohammad AlFalasi, Jason Y K Chan, Pankaj Chaturvedi, Velda Ling Yu Chow, Andreas Dietz, Johannes J Fagan, Christian Godballe, Wojciech Golusiński, Akihiro Homma, Sefik Hosal, N Gopalakrishna Iyer, Cyrus Kerawala, Yoon Woo Koh, Anna Konney, Luiz P Kowalski, Dennis Kraus, Moni A Kuriakose, Efthymios Kyrodimos, Stephen Y Lai, C Rene Leemans, Paul Lennon, Lisa Licitra, Pei-Jen Lou, Bernard Lyons, Haitham Mirghani, Anthonny C Nichols, Vinidh Paleri, Benedict J Panizza, Pablo Parente Arias, Mihir R Patel, Cesare Piazza, Danny Rischin, Alvaro Sanabria, Robert P Takes, David J Thomson, Ravindra Uppaluri, Yu Wang, Sue S Yom, Yi-ming Zhu, Sandro V Porceddu, John R de Almeida, Chrisian Simon, F Christopher Holsinger
Journal: The Lancet Oncology (2020)
SAT0447 CORRELATES OF RADIAL BONE MICROARCHITECTURES IN OLDER ADULTS
Authors: C. Ma, F. Pan, F. Wu, H. H. Nguyen, L. Laslett, T. Winzenberg, G. Jones
Journal: Annals of the Rheumatic Diseases (2020)

Background: Weight, dietary patterns, vitamin D, physical activity and grip strength have been suggested to be associated with bone loss in older adults. However, studies have yet been performed to investigate the associations between these factors and radial bone microarchitecture. Objectives: This study aimed to describe the associations of weight, dietary patterns, serum 25-hydroxyvitamin D (25(OH)D) concentrations, physical activity and grip strength with bone measures in older adults. Methods: Cross-sectional data on 201 older adults (mean age 72 years, female 46%) from a population-based cohort study were analysed. Weight, dietary patterns, serum 25(OH)D concentrations, physical activity (steps per day), grip strength were collected and analysed from baseline to 10-year follow-up. Areal bone mineral density (aBMD) at spine, hip and whole body were measured by dual-energy X-ray absorptiometry (DXA). Radial cortical and trabecular bone microarchitectures were measured by high-resolution peripheral computed tomography (HRpQCT). Multivariable linear regression was used to analyse associations of study factors with bone measures. Results: Weight was positively associated with radial bone area (total: β=0.18, 95% CI: 0.07, 0.29; cortical: β=0.12, 95% CI: 0.03, 0.21; trabecular: β=0.18, 95% CI: 0.05, 0.32), and was inversely associated with compact cortical volumetric bone mineral density (vBMD) (β= -0.19, 95% CI: -0.37, -0.01) and trabecular thickness (β= -0.25, 95% CI: -0.43, -0.07). Ten-year changes in weight were not significantly associated with bone measures, apart from radial trabecular separation (β= 0.15, 95%CI: 0.009, 0.28). Western dietary pattern scores were inversely associated with radial vBMD (total: β= -0.17, 95% CI: -0.32, -0.01; cortical: β= -0.19, 95% CI: -0.34, -0.04; compact cortical: β= -0.19, 95% CI: -0.34, -0.04; outer transitional zone: β= -0.20, 95% CI: -0.35, -0.06), and were positively associated with cortical porosity (cortical: β= 0.18, 95% CI: 0.03, 0.33; compact cortical: β= 0.19, 95% CI: 0.04, 0.34; outer transitional zone: β= 0.20, 95% CI: 0.06, 0.35). Steps per day were not significantly associated with bone measures, apart from inner transitional zone area and thickness (β= 0.12, 95% CI: 0.003, 0.24; β= 0.19, 95% CI: 0.05, 0.33). Healthy food pattern scores, serum 25(OH)D and grip strength were not significantly associated with radial HRpQCT measures. Conclusion: Higher weight, but not weight change, was beneficial for radial cortical and trabecular bone area but also associated with worse compact cortical vBMD and trabecular thickness. Higher western dietary pattern scores had adverse effects on radial vBMD and cortical porosity while physical activity had inconsistent associations. Disclosure of Interests: None declared
Abstract 16268: Bone Marrow Adipose Tissue Volume: A Novel CT Imaging Marker of Cardiovascular Diseases Risk
Authors: Shady Abohashem, Tawseef Dar, Michael T. Osborne, Ahmed A Tawakol
Journal: Circulation (2019)

Introduction and Hypothesis: Heightened leukopoietic activity associated with an increased risk of major adverse cardiovascular disease events (MACE). Bone marrow adipose tissue (BMAT) is known to ...
In COVID-19, adding lopinavir–ritonavir to usual care did not shorten time to clinical improvement
Authors: Philip Yang, Seema Tekwani, Greg S. Martin
Journal: Annals of Internal Medicine (2020)

Source CitationCao B, Wang Y, Wen D, et al. A trial of lopinavir–ritonavir in adults hospitalized with severe Covid-19. N Engl J Med. 2020;382:1787-99. https://pubmed.ncbi.nlm.nih.gov/32187464/AbstractClinical Impact RatingsGIM/FP/GP: Hospitalists: Infectious Disease: Pulmonology: