tbuckley/cabot-search huggingface dataset:
Covid-19: Deaths in Mexico triple since reopening began in June
Authors: Elisabeth Mahase
Journal: BMJ (2020)

Covid-19 deaths in Mexico have tripled since the country started to relax lockdown measures on 1 June, rising from 10 167 deaths to 32 796 deaths by 9 July, latest figures show.The data, compiled by John Hopkins University in Maryland, USA, 1 also found that the number of cases had risen by 194% over that period, from 93 435 to 275 003.Mexico began gradually reopening businesses in June despite warnings that case numbers were still high and that easing restrictions could make the situation worse. 2 In May the New York Times revealed that the Mexican government had not been accurately reporting the number of cases and deaths despite local officials repeatedly alerting it to the true numbers, which in some cases were three times the value reported.The government had also been criticised early on for downplaying the threat from the virus. 3 However, as cases are also rising in the US, residents in northern Mexican towns are asking people from the US not to cross the border, for fears that tourists will increase transmission.People in Sonoyta, a town on the Arizona border, have even used their vehicles to block the road leading to Puerto Peñasco, a popular beach town. 4 The US has reported the highest rates of the virus in the world: Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, warned that he would not be surprised to see the country reach 100 000 new cases a day. 5 As of 9 July the US had reported more than three million cases and over 130 000 covid-19 deaths.Mexico is just one of many countries that have seen spikes in cases after easing restrictions.In places such as Melbourne (Australia), Beijing (China), Leicester (England), and North Rhine-Westphalia (Germany) governments have been forced to implement local lockdown measures to try to bring the number of new cases back down after they began reopening. 6
Wearable devices can predict the outcome of standardized 6-minute walk tests in heart disease
Authors: Charlotte Schubert, Gareth Archer, Jo M. Zelis, Sarah Nordmeyer, Kilian Runte, Anja Hennemuth, Felix Berger, Volkmar Falk, Pim A. L. Tonino, Rod Hose, Herman ter Horst, Titus Kuehne, Marcus Kelm
Journal: npj Digital Medicine (2020)

Wrist-worn devices with heart rate monitoring have become increasingly popular. Although current guidelines advise to consider clinical symptoms and exercise tolerance during decision-making in heart disease, it remains unknown to which extent wearables can help to determine such functional capacity measures. In clinical settings, the 6-minute walk test has become a standardized diagnostic and prognostic marker. We aimed to explore, whether 6-minute walk distances can be predicted by wrist-worn devices in patients with different stages of mitral and aortic valve disease. A total of n = 107 sensor datasets with 1,019,748 min of recordings were analysed. Based on heart rate recordings and literature information, activity levels were determined and compared to results from a 6-minute walk test. The percentage of time spent in moderate activity was a predictor for the achievement of gender, age and body mass index-specific 6-minute walk distances (p < 0.001; R2 = 0.48). The uncertainty of these predictions is demonstrated.
P-227 Prognostic and predictive factors of platinum-based chemotherapy in gastroenteropancreatic neuroendocrine neoplasms G3
Authors: A. Kolasinska-Cwikła, J. Ćwikła, K. Roszkowska-Purska, R. Samsel, A. Cichocki, J. Pałucki, L. Wyrwicz
Journal: Annals of Oncology (2020)
Abstract 13680: Preclinical Validation of a Device-Set of Impedance- and Magnetic Resonance Tracked Metallic Devices for Conventional and Mr-Guided Electrophysiological Intervention
Authors: Akbar Alipour, Ehud J Schmidt, Aravindan Kolandaivelu, Michael Guttman, Jeffrey Schweitzer, Gregory Olson, Henry R Halperin
Journal: Circulation (2019)

Introduction: We previously demonstrated MBalun radio-frequency (RF) traps [1] that rendered metallic-backbone interventional devices MRI-conditional with only a 20% diameter increase, while preser...
P-228 SGNLVA-005: Open-label, phase 2 study of ladiratuzumab vedotin (LV) for aerodigestive tract malignancies
Authors: T. Guthrie, N. Gabrail, A. Sher, J. Bruce, R. Sanborn, A. Lee, R. Graham, I. Tafur, A. Pippas, Y. Wang, Z. Wang, I. Anderson
Journal: Annals of Oncology (2020)
Abstract 10151: Use of an Electronic Decision Support Tool Improves Team Performance During in-situ Simulation of In-hospital Cardiac Arrest
Authors: Rachel S Chang, Sharon Kam, Santiago Angaramo, Matthew D McEvoy, Britany Raymond
Journal: Circulation (2019)

Introduction: The Advanced Cardiac Life Support (ACLS) algorithms published by the American Heart Association (AHA) represent evidence-based management of in-hospital cardiac arrest (IHCA). Increas...
Identifying oncogenic drivers associated with increased risk of late distant recurrence in postmenopausal, estrogen receptor-positive, HER2-negative early breast cancer: results from the BIG 1-98 study
Authors: S.J. Luen, R. Asher, C.K. Lee, P. Savas, R. Kammler, P. Dell’Orto, O.M. Biasi, D. Demanse, W. Hackl, B. Thuerlimann, G. Viale, A. Di Leo, M. Colleoni, M.M. Regan, S. Loi
Journal: Annals of Oncology (2020)
メープルシロップ尿症:ヌクレオチド配列と当疾患の患者の遺伝子分析から推測されるヒト分岐鎖アルファケト酸脱水素酵素錯体のE1-ベータサブユニットの完全な一次構造
Authors: Nobukuni Y, Mitsubuchi H, Endo F, Akaboshi I, Asaka J, Matsuda I
Journal: Journal of Clinical Investigation (1990)
Imaging resident and recruited macrophage contribution to Wallerian degeneration
Authors: Alexandre Boissonnas, Floriane Louboutin, Marie Laviron, Pierre-Louis Loyher, Elodie Reboussin, Sandrine Barthelemy, Annabelle Réaux-Le Goazigo, Christian S. Lobsiger, Béhazine Combadière, Stéphane Mélik Parsadaniantz, Christophe Combadière
Journal: The Journal of Experimental Medicine (2020)

Wallerian degeneration (WD) is a process of autonomous distal degeneration of axons upon injury. Macrophages (MPs) of the peripheral nervous system (PNS) are the main cellular agent controlling this process. Some evidence suggests that resident PNS-MPs along with MPs of hematogenous origin may be involved, but whether these two subsets exert distinct functions is unknown. Combining MP-designed fluorescent reporter mice and coherent anti–Stokes Raman scattering (CARS) imaging of the sciatic nerve, we deciphered the spatiotemporal choreography of resident and recently recruited MPs after injury and unveiled distinct functions of these subsets, with recruited MPs being responsible for efficient myelin stripping and clearance and resident MPs being involved in axonal regrowth. This work provides clues to tackle selectively cellular processes involved in neurodegenerative diseases.
Phosphorylated EGFR on tumor-associated endothelial cells in human renal cell carcinoma is a primary target for therapy by tyrosine kinase inhibitors.
Authors: Anita Gaurnier, Yamini Sabherwal, Svetoslav Dimitrov, George P. Tuszynski
Journal: Cancer Research (2006)

5702  Our laboratory recently isolated a novel protein from lung carcinoma which has been found to inhibit tumor growth, metastasis, and angiogenesis in both in vitro and in vivo animal studies. This protein, termed Angiocidin, is over-expressed in a wide range of tumor tissue and is present at elevated levels in the blood of patients with advanced cancers. Subsequent to these initial studies, we have also obtained preliminary data indicating that Angiocidin may play a significant role in immune system modulation by functioning as a proinflammatory mediator. Activation of the acute monocytic leukemia cell line THP-1 with phorbol-12-myristate-13-acetate resulted in secretion of Angiocidin in the pg/mL range, as quantitated by an Angiocidin capture ELISA developed by our lab. This result was also observed with peripheral blood mononuclear cells (PBMCs), indicating potential cytokine-like activities for this molecule. MDA-MB-231 breast adenocarcinoma, Colo 357 pancreatic carcinoma, and DAOY medulloblastoma cell lines, as well as Human Umbilical Vein Endothelial Cells (HUVECs), have also been demonstrated to secrete Angiocidin. Flow cytometric analysis of PBMCs has demonstrated that Angiocidin also acts as a potent activator of both monocytes and lymphocytes. This activity has been titered to as little as 1 μg/mL Angiocidin. Flow cytometric analysis and human cytokine antibody arrays have shown various cytokines to be secreted from monocytes in response to Angiocidin treatment, including Monocyte Chemotactic Proteins 1 and 2, Interleukins 6, 10, and 12, and TNF-α. Using the THP-1 cell line, we have also demonstrated Angiocidin-induced monocyte activation immunocytochemically. Treated with 1 μg/mL Angiocidin for 24 hours causes cell-substratum adhesion. Cells morphologically resemble tissue macrophages, showing distinct focal adhesion and stress fiber formation. In addition to cytokine release, Angiocidin also stimulates secretion of several matrix-degrading enzymes, namely MMP-9 from THP-1 cells and PBMCs, and MMP-2 from HUVECs. Accordingly, conditioned media from Angiocidin-treated THPs has been shown to act as a potent inducer of monocyte invasion through Collagen Type I and gelatin. These data suggest a potential immunologic mechanism by which Angiocidin may exert its antitumor effect. We hypothesize that reduced tumor growth previously observed in Angiocidin-treated mice may be partly attributable to the specific cytokine profile found within the tumor microenvironment, as well as to enhanced leukocyte infiltration into the tumor bed. The focus of this project is to expand upon these data and elucidate the functional roles this molecule plays in modulating an immune response.
P-237 Impact of adjuvant chemotherapy in poorly cohesive gastric carcinoma: Experience from the Peruvian National Cancer Institute
Authors: M. Serrano, J. Araujo, C. Pacheco-Román, J. Macetas, F. Berrospi, E. Ruiz, C. Luque, L. Taxa, P. Montenegro
Journal: Annals of Oncology (2020)
P-126 Markers of tumour inflammation are prognostic for overall survival in patients with advanced pancreatic ductal adenocarcinoma receiving FOLFIRINOX chemotherapy
Authors: J. Appleyard, K. Kamposioras, G. Papaxoinis, F. Collinson, U. Ahmad, F. Wright, I. Damyanova, M. Razzaq, A. Anthoney
Journal: Annals of Oncology (2020)
Super-enhancer-driven metabolic reprogramming promotes cystogenesis in autosomal dominant polycystic kidney disease
Authors: Zeyun Mi, Yandong Song, Xinyi Cao, Yi Lu, Zhiheng Liu, Xu Zhu, Meijuan Geng, Yongzhan Sun, Bingxue Lan, Chaoran He, Hui Xiong, Lirong Zhang, Yupeng Chen
Journal: Nature Metabolism (2020)
Phosphoproteomic quantitation and causal analysis reveal pathways in GPVI/ITAM-mediated platelet activation programs
Authors: Özgün Babur, Alexander R. Melrose, Jennifer M. Cunliffe, John Klimek, Jiaqing Pang, Anna-Liisa I. Sepp, Jevgenia Zilberman-Rudenko, Samuel Tassi Yunga, Tony Zheng, Iván Parra-Izquierdo, Jessica Minnier, Owen J. T. McCarty, Emek Demir, Ashok P. Reddy, Phillip A. Wilmarth, Larry L. David, Joseph E. Aslan
Journal: Blood (2020)
The CROONIAN LECTURES: CONTRIBUTION to the HISTORY of the RESPIRATION of MAN: Delivered before the Royal College of Physicians of London
Authors: W. Marcet
Journal: BMJ (1895)

Before entering on the subject proper of this lecture I must beg leave to glance at a few of the prominent contributions to our knowledge of the phenomena of human respiration.In 1819 Regnault and Reiset, from experiments on animals, observed that a marked volume of oxygen was taken in at the lungs which failed to reappear as carbonic acid in the ex- pired air, and they established a relation between the oxygen consumed and the carbonic acid produced.These experi- ments were confirmed in 1891 by Messrs. Chapman and trubecker, of Philadelphia.Dr. Edward Smith, in a paper published in 1859, divides foods into two classes, according to their action on respiration-the excito-respiratory, which increase the production of carbonic acid, and the non-excitants, which have a con- trary effect.In the former class he includes, tea, sugar, coffee, rum, milk, cocoa, etc.; also gelaiine and albumen, though their effect is less marked.Rum and milk have a very pronounced and persistent action.Two results are prominent in this paper: first, that fats, oils (codliver oil), and starch diminish the carbonic acid expired;secondly, that although the ingestion of pure alcohol and rum act as respiratory excitants, still, drinking brandy, whisky, and gin is attended with a diminution of the car- bonic acid expired.The elaborate chamber, constructed by Pettenkofer, of Munich, in 1863, and hia important inquiries with Professor Voit into the respiration of man should be placed here on record.In 1874 C. Speck published important papers on respiration.He observed, as will be confirmed in the present lecture, that on returning to natural respiration after forced breathing, and therefore in consequence of increased ventila- tion of the blood, much less air is expired for a short time than in ordinary breathing in repose; and also that the amount of carbonic acid expired in the after effect of forced breathing falls considerably below the normal.The oxygen taken from the air is also momentarily reduced.In 1878 Paul Bert's remarkable book on The Effect.s of Baro- metric Pressure on Respiration was published, and in it he states that animals dying in closed vessels, and consequently in their own carbonic acid, exhibit precisely the same symptoms as if they had perished under diminished atmospheric pressure, from which he concludes that carbonic acid is absolutely innocuous, and that in such cases death is due to want of oxygen.
Covid-19: reduced asthma presentations in children
Authors: Richard J Chavasse
Journal: BMJ (2020)

The impact of covid-19 on children will continue for years, affecting them educationally, emotionally, and financially, with indirect effects on their health.1 Children must not be sidelined as we rebuild and redesign systems for the future.

One “benefit” of the pandemic has been the reduced number of paediatric hospital admissions. Reports from other countries indicated that acute covid-19 in children was milder than adults, rarely resulting in admission.23 We found unexpected reductions in other …
Abstract 16076: Initial Experience on Ivus-Guided Pulmonary Artery Angioplasty and Stent Implantation in Patients With Chronic Thromboembolic Pulmonary Hypertension
Authors: Alvaro Calabuig Goena, Bernat Serra Creus, Gerard Marti Aguasca, Antonio Roman Broto, Manuel Lopez-Meseguer, Daniel Valcarcel Paz, Enric Domingo Ribas
Journal: Circulation (2018)

Introduction: Pulmonary artery angioplasty (PAA) is a treatment option for patients with pulmonary hypertension due to chronic thromboembolism, who are rejected for surgical pulmonary endarterectom...
O-19 Feasibility of switching to S-1 upon other fluoropyrimidine-related cardiotoxicity during chemotherapy for solid tumors
Authors: P. Osterlund, S. Kinos, P. Halonen, L. Soveri, R. Kwakman, T. Salminen, R. McDermott, P. Pfeiffer, E. Heervä, G. Liposits, R. Röckert, A. Ålgars, R. Ristamäki, R. Kallio, H. Sorbye, P. Flygare, H. Hagman, C. Shah, A. Teske, E. van Werkhoven, B. Glimelius, C. Punt
Journal: Annals of Oncology (2020)
P-200 Bone metastases from colorectal cancer correlate with biological characteristics of primary tumors: A retrospective analysis from a single institution
Authors: E. Giunta, V. De Falco, S. Napolitano, P. Vitale, N. Zanaletti, M. Terminiello, V. Caputo, P. Vitiello, D. Ciardiello, C. Borrelli, L. Poliero, G. Arrichiello, C. Cardone, G. Martini, E. Martinelli, F. Ciardiello, T. Troiani
Journal: Annals of Oncology (2020)
Gentamicin-Induced Acute Kidney Injury in an Animal Model Involves Programmed Necrosis of the Collecting Duct
Authors: Huihui Huang, William W. Jin, Ming Huang, Heyu Ji, Diane E. Capen, Yin Xia, Junying Yuan, Teodor G. Păunescu, Hua A. Jenny Lu
Journal: Journal of the American Society of Nephrology (2020)

Significance Statement Gentamicin-induced AKI is a commonly recognized clinical problem, but the mechanism is not well understood. A mouse model of gentamicin-induced AKI revealed a previously unrecognized role of necroptosis in mediating collecting duct epithelial cell death, interstitial inflammation, and fibrosis. Importantly, either inhibiting a necroptotic pathway activator RIPK1 kinase with its inhibitor Nec-1 or deleting a key necroptotic gene, Ripk3 , significantly attenuated gentamicin-induced AKI in mice and in cultured porcine and murine kidney tubular cells. Identification of a novel programmed necroptosis pathway in gentamicin-induced renal tubule injury could provide a new therapeutic target. Background Gentamicin is a potent aminoglycoside antibiotic that targets gram-negative bacteria, but nephrotoxicity limits its clinical application. The cause of gentamicin-induced AKI has been attributed mainly to apoptosis of the proximal tubule cells. However, blocking apoptosis only partially attenuates gentamicin-induced AKI in animals. Methods Mice treated with gentamicin for 7 days developed AKI, and programmed cell death pathways were examined using pharmacologic inhibitors and in RIPK3-deficient mice. Effects in porcine and murine kidney cell lines were also examined. Results Gentamicin caused a low level of apoptosis in the proximal tubules and significant ultrastructural alterations consistent with necroptosis, occurring predominantly in the collecting ducts (CDs), including cell and organelle swelling and rupture of the cell membrane. Upregulation of the key necroptotic signaling molecules, mixed lineage kinase domain-like pseudokinase (MLKL) and receptor-interacting serine/threonine-protein kinase 3 (RIPK3), was detected in gentamicin-treated mice and in cultured renal tubule cells. In addition, gentamicin induced apical accumulation of total and phosphorylated MLKL (pMLKL) in CDs in mouse kidney. Inhibiting a necroptotic protein, RIPK1, with necrostatin-1 (Nec-1), attenuated gentamicin-induced necrosis and upregulation of MLKL and RIPK3 in mice and cultured cells. Nec-1 also alleviated kidney inflammation and fibrosis, and significantly improved gentamicin-induced renal dysfunction in mice. Furthermore, deletion of RIPK3 in the Ripk3 −/− mice significantly attenuated gentamicin-induced AKI. Conclusions A previously unrecognized role of programmed necrosis in collecting ducts in gentamicin-induced kidney injury presents a potential new therapeutic strategy to alleviate gentamicin-induced AKI through inhibiting necroptosis.
SO-30 Adjuvant systemic chemotherapy versus active surveillance following upfront resection of isolated synchronous colorectal peritoneal metastases: Propensity score-matched analysis of a nationwide registry
Authors: K. Rovers, C. Bakkers, F. van Erning, J. Burger, S. Nienhuijs, G. Simkens, G. Creemers, P. Hemmer, C. Punt, V. Lemmens, P. Tanis, I. de Hingh
Journal: Annals of Oncology (2020)
Genome-Wide Association Study Data Reveal Genetic Susceptibility to Chronic Inflammatory Intestinal Diseases and Pancreatic Ductal Adenocarcinoma Risk
Authors: Fangcheng Yuan, Rayjean J. Hung, Naomi Walsh, Han Zhang, Elizabeth A. Platz, William Wheeler, Lei Song, Alan A. Arslan, Laura E. Beane Freeman, Paige Bracci, Federico Canzian, Mengmeng Du, Steven Gallinger, Graham G. Giles, Phyllis J. Goodman, Charles Kooperberg, Loic Le Marchand, Rachel E. Neale, Jonas Rosendahl, Ghislaine Scelo, Xiao-Ou Shu, Kala Visvanathan, Emily White, Wei Zheng, Demetrius Albanes, Pilar Amiano, Gabriella Andreotti, Ana Babic, William R. Bamlet, Sonja I. Berndt, Paul Brennan, Bas Bueno-de-Mesquita, Julie E. Buring, Peter T. Campbell, Stephen J. Chanock, Charles S. Fuchs, J. Michael Gaziano, Michael G. Goggins, Thilo Hackert, Patricia Hartge, Manal M. Hassan, Elizabeth A. Holly, Robert N. Hoover, Verena Katzke, Holger Kirsten, Robert C. Kurtz, I-Min Lee, Nuria Malats, Roger L. Milne, Neil Murphy, Kimmie Ng, Ann L. Oberg, Miquel Porta, Kari G. Rabe, Francisco X. Real, Nathaniel Rothman, Howard D. Sesso, Debra T. Silverman, Ian M. Thompson, Jean Wactawski-Wende, Xiaoliang Wang, Nicolas Wentzensen, Lynne R. Wilkens, Herbert Yu, Anne Zeleniuch-Jacquotte, Jianxin Shi, Eric J. Duell, Laufey T. Amundadottir, Donghui Li, Gloria M. Petersen, Brian M. Wolpin, Harvey A. Risch, Kai Yu, Alison P. Klein, Rachael Stolzenberg-Solomon
Journal: Cancer Research (2020)

Registry-based epidemiologic studies suggest associations between chronic inflammatory intestinal diseases and pancreatic ductal adenocarcinoma (PDAC). As genetic susceptibility contributes to a large proportion of chronic inflammatory intestinal diseases, we hypothesize that the genomic regions surrounding established genome-wide associated variants for these chronic inflammatory diseases are associated with PDAC. We examined the association between PDAC and genomic regions (±500 kb) surrounding established common susceptibility variants for ulcerative colitis, Crohn's disease, inflammatory bowel disease, celiac disease, chronic pancreatitis, and primary sclerosing cholangitis. We analyzed summary statistics from genome-wide association studies data for 8,384 cases and 11,955 controls of European descent from two large consortium studies using the summary data-based adaptive rank truncated product method to examine the overall association of combined genomic regions for each inflammatory disease group. Combined genomic susceptibility regions for ulcerative colitis, Crohn disease, inflammatory bowel disease, and chronic pancreatitis were associated with PDAC at
SO-25 A multicenter phase II study of eribulin in patients with BRAF V600E mutant metastatic colorectal cancer: BRAVERY study (EPOC1701)
Authors: T. Masuishi, H. Taniguchi, D. Kotani, H. Bando, Y. Komatsu, E. Shinozaki, T. Nakajima, T. Satoh, T. Nishina, T. Esaki, M. Wakabayashi, S. Nomura, K. Takahashi, H. Ono, N. Hirano, N. Fujishiro, N. Fuse, A. Sato, A. Ohtsu, T. Yoshino
Journal: Annals of Oncology (2020)
DISC: a highly scalable and accurate inference of gene expression and structure for single-cell transcriptomes using semi-supervised deep learning
Authors: Yao He, Hao Yuan, Cheng Wu, Zhi Xie
Journal: Genome biology (2020)

Abstract Dropouts distort gene expression and misclassify cell types in single-cell transcriptome. Although imputation may improve gene expression and downstream analysis to some degree, it also inevitably introduces false signals. We develop DISC, a novel deep learning network with semi-supervised learning to infer gene structure and expression obscured by dropouts. Compared with seven state-of-the-art imputation approaches on ten real-world datasets, we show that DISC consistently outperforms the other approaches. Its applicability, scalability, and reliability make DISC a promising approach to recover gene expression, enhance gene and cell structures, and improve cell type identification for sparse scRNA-seq data.
Pattern recognition receptor‐mediated inflammation in diabetic vascular complications
Authors: Xu Wang, Victor Antony, Yi Wang, Gaojun Wu, Guang Liang
Journal: Medicinal Research Reviews (2020)

Abstract The innate immune system contains multiple classes of pattern recognition receptors (PRRs), which recognize pathogen‐associated molecular patterns (PAMPs) and danger‐associated molecular patterns (DAMPs) in the intracellular and extracellular space. Although PRRs are indispensable for the detection and clearance of invading pathogens, dysregulated PRR activation by extrinsic and intrinsic factors leads to inflammatory diseases. PRR‐mediated inflammation has been shown to play a pivotal role in the pathogenesis of diabetic vascular complications (DVCs), which are the leading causes of morbidity and mortality in diabetic patients. Upon sensing hyperglycemia‐generated DAMPs, PRRs activate intracellular signaling pathways leading to the production of proinflammatory cytokines and chemokines in various cells of the kidney, brain, eye, and heart. The resulting chronic, low‐grade inflammation contributes to DVCs. In this review, we summarize the role of PRRs in DVCs including diabetic nephropathy, neuropathy, retinopathy, and cardiomyopathy. We propose that targeting PRRs and associated signaling pathways may be beneficial for the management of DVCs.