tbuckley/cabot-search huggingface dataset:
Infographic. UEFA expert group 2020 statement on nutrition in elite football
Authors: James Collins, Ronald John Maughan, Mike Gleeson, Johann Bilsborough, Asker Jeukendrup, James P Morton, S M Phillips, Lawrence E Armstrong, Louise M Burke, Graeme L Close, Rob Duffield, Enette Larson-Meyer, Julien Louis, Daniel Medina, Flavia Meyer, Ian Rollo, Jorunn Kaiander Sundgot-Borgen, Benjamin Wall, Beatriz Boullosa, Gregory Dupont, Antonia Lizarraga, Peter Res, Mario Bizzini, Carlo Castagna, Charlotte M Cowie, Michel D"Hooghe, Hans Geyer, Tim Meyer, Niki Papadimitiou, Marc Vouillamoz, Alan McCall
Journal: British Journal of Sports Medicine (2020)

Infographic 1: UEFA 2020 expert group statement in elite football: Training day.





Infographic 2: UEFA 2020 expert group statement in elite football: match-day.





Infographic 3: UEFA 2020 expert group statement in elite football: Best of the rest—8 other key take-home messages.



UEFA commissioned an expert group statement on nutrition in elite football.1 Gathering 32 global experts in football and nutrition research …
AB0064 Comparative evalution of oral enzymes versus standard therapy in aspect to efficacy and tolerability in treatment of rheumatoid arthritis and juvenile idiophatic arthritis
Authors: M Zeibarts, I Purvinsh, H Mikazhane, R Shantere, V Stanevicha, A Scegolevs
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> Tolerability and side effects of standard therapy used in rheumatology are the most serious problem, especially if treatment must be started in early age. Gastrointestinal endoscopies allow to detect injury of gastrointestinal mucosa in up to 75% patients, who are using NSAIDs over longer period. Adjuvant treatment with omeprazol or nizoprostol raises the cost of treatment. For this purpose oral enzymes (OE) can be used in treatment of joint diseases, as they possess the properties of both basic medications and antiinflammatory drugs. Oral enzymes – Phlogenzym allow to refuse from NSAIDs or to shorten the course of NSAIDs. <h3>Objectives</h3> The goal of the present evaluation was to assess the efficacy and tolerability of Phlogenzym in treatment of joint diseases;1) versus NSAIDs, 2) versus DMARDs. <h3>Methods</h3> We evaluated total 86 patients of both genders with first time diagnosed illness. 40 RA patients aged between 20 – 62 years: 20 patients got DMARDs and Phlogenzym,20 patients got DMARDs and NSAIDs. 46 JIA patients aged between 7 – 17 years: 23 patients got Phlogenzym and shorter course of NSAIDs, 23 patients got standard therapy DMARDs and shorter course of NSAIDs. <h3>Results</h3> after the RA patients treatment during 4 months the efficacy of combined treatment with DMARDs and OE was estimated as superior 84% versus DMARDs and NSAIDs as 75%. Integrative tolerability rate was in RA treatment as 3,8 vs. 3,6. after the JIA patients treatment during 3 months the efficacy of combined treatment with OE and NSAIDs was estimated as superior 70% versus DMARDs and NSAIDs as 53%. Integrative tolerability rate was in JIA treatment identical. Otherwise we obtained elimination of Helicobater pylori after adequate treatment in all 7 Helicobacter pylori (+) cases in JIA patients treated with OE, healing of duodenal ulcer in 1 patients and healing of erosive gastritis in 3 patients. Among 5 Helicobacter pylori (+) patients treated with DMARDs and NSAIDs only 1 became Helicobacter pylori (-) after same "Tripl" therapy (Amoxicillinum, Metronidazolum, Ranitidinum/Omeprazolum). <h3>Conclusion</h3> Our evaluation corresponding to the judgements given by the doctors concerning efficacy and tolerability to tested drugs shows that treatment with Phlogenzym was safe and more effective. According to these results it can be stated that OE is the group of medicines, which may be used for substitution of DMARDs or NSAIDs considering to course of disease and concomitant pathologies.
Novel molecular targets in gastric adenocarcinoma
Authors: Roya Ramezankhani, Roya Solhi, Hamidreza Aboulkheyr Es, Massoud Vosough, Moustapha Hassan
Journal: Pharmacology & Therapeutics (2020)

Gastric adenocarcinoma (GAC) is the third leading cause of cancer-related death worldwide. A high mortality rate and resistance to treatment protocols due to a heterogeneous molecular pathogenesis has made discovering the key etiologic molecular alterations of the utmost importance. The remarkable role played by epigenetic modifications in repressing or activating many cancer-related genes and forming new epigenetic signatures can affect cancer initiation and progression. Hence, targeting the key epigenetic drivers could potentially attenuate cancer progression. MLLs, ARID1A and EZH2 are among the major epigenetic players that are frequently mutated in GACs. In this paper, we have proposed the existence of a network between these proteins that, together with PCAF and KDM6A, control the 3D chromatin structure and regulate the expression of tumor suppressor genes (TSGs) and oncogenes in GAC. Therefore, we suggest that manipulating the expression of EZH2, PCAF, and KDM6A or their downstream targets may reduce the cancerous phenotype in GAC.
TCT CONNECT-42 Artificial Intelligence Single Lead ECG as a Blueprint for Symptom-to-Balloon Time Reduction
Authors: Sameer Mehta, Francisco Fernandez, Carlos Villagran, Daniel Vieira, Gladys Pinto, Lorena Pisana, Daniela Bou Daher, Lilly Prieto, Camila Narváez-Caicedo, Claudia Lopez
Journal: Journal of the American College of Cardiology (2020)
Abstract 13650: Influence of Parathyroid Hormone on Incidence of Heart Failure Event in Patients Without History of Cardiovascular Disease
Authors: Satoru Sakuragi, Keishi Ichikawa
Journal: Circulation (2015)

Introduction: Parathyroid hormone (PTH) plays an important role in bone metabolism. High PTH level increases intracellular calcium in arterial wall, which causes hypertension and left ventricular hypertrophy. However, information on the association of PTH level with cardiovascular event in general population is still lacking. In this study, we investigated the association of PTH with biochemical and echocardiographic measurements of cardiovascular structure and function, and the influence of PTH on incidence of heart failure (HF) admission in patients without history of cardiovascular disease. Methods: 172 subjects (84male, 68years) without history of cardiovascular disease were enrolled from September 2012 to April 2013. Subjects with LV dysfunction (LVEF &lt;50%) and advanced chronic kidney disease (eGFR&lt;15 ml/min/1.73m2) were excluded. Parathyroid function was assessed with intact PTH (iPTH). We examined the association of iPTH with biochemiacl markers, such as NT-proBNP, high-sensitive cardiac Troponin T (hs-cTnT), and echocardiographic markers, such as left atrial volume index (LAVI), left ventricular mass index (LVMI), LVEF, E/e.Associations of iPTH with these cardiac markers were evaluated by univariable and multivariable linear regression analysis. Association of iPTH with future cardiovascular event was also evaluated by using multiple Cox regression analysis. Results: In multivariable analyysis, log NT-proBNP (p=0.0121) as well as log hs-cTnT (p=0.0024) was associated with iPTH. Among echocardiographic measurements, LAVI (p=0.0161), LVMI (p=0.0343) and E/e (p=0.0001) were associated with iPTH after adjustment for age, gender, cholesterol and eGFR. In multivariate Cox regression analysis, increasing iPTH was associated with incidence of HF admission with a hazard ratio of 6.39 for iPTH over 60 pg/ml (95% CI: 1.003 to 46.111, p=0.0047) after adjustment for age, gender, prevalence of hypertension, diabetes mellitus, dyslipidemia, systolic blood pressure and heart rate. Conclusions: Parathyroid hormone is associated with greater cardiac markers and future heart failure. Our results suggest that treatment to reduced PTH level is helpful to prevent future cardiac event.
TCT CONNECT-247 Outcomes of Percutaneous Coronary Intervention in Cardiac Transplant Patients: A Bi-national Analysis Derived From the United Kingdom and United States
Authors: Vinayak Nagaraja, Muhammad Rashid, H. Anderson, Peter Ludman, Samir Kapadia, Randall Starling, M. Chadi Alraies, Shing Kwok, None Mohamed, Nick Curzen, Mamas Mamas
Journal: Journal of the American College of Cardiology (2020)
Soft tissue coverage using pedicled flap in combat zone: a case series
Authors: Laurent Mathieu, Soryapong Plang, Nicolas de l’Escalopier, James Charles Murison, Christophe Gaillard, Antoine Bertani, Frédéric Rongieras
Journal: Military Medical Research (2020)

Abstract Background Soft tissue reconstruction is typically conducted after evacuation from theater of operations. If circumstances do not allow timely evacuation, however, defect site may need to be reconstructed in the combat zone. Case presentation A total of 41 patients with extremity soft tissue defect were treated using pedicled flaps by a single orthopedic surgeon during four deployments in Chad, Afghanistan and Mali between 2010 and 2017. The mean age was 25.6 years. A total of 46 injury sites in extremities required flap coverage: 19 combat-related injuries (CRIs) and 27 non-combat related injuries (NCRIs). Twenty of the injury sites were infected. Overall, 63 pedicled flap transfers were carried out: 15 muscle flaps, 35 local fasciocutaneous flaps and 13 distant fasciocutaneous flaps. The flap types used did not differ for CRIs or NCRIs. Mean follow-up was 71 days. Complications included deep infection ( n = 6), flap failure ( n = 1) and partial flap necrosis ( n = 1). Limb salvage rate was 92.7% (38/41). Conclusions Soft tissue defect can be managed with simple pedicled flaps in theatre of operations if needed. Basic reconstructive procedures should be part of the training for military orthopedic surgeons. Trial registration Retrospectively registered in January 2019 (2019-0901-001).
TCT CONNECT-292 A Comparison of Figure-of-8 Suture Versus Manual Compression for Venous Access Closure After Cardiac Procedures: An Updated Meta-Analysis
Authors: Mark Terence Mujer, Jairus Adrian Flores, Bin Rashid Chin, Ardy Fenando, Christopher Garces, Thamer Almalki, Lakshmi Akhila Nerusu, Ahmad Elshafie, Manel Boumegouas, Lawrenshey Charles, Peter Robinson
Journal: Journal of the American College of Cardiology (2020)
Our choice is not binary between lockdown and herd immunity
Authors: K K Cheng
Journal: BMJ (2020)

All scientists who argue for caution share Sikora and colleagues’ desire for normality.12 Our case against their position has been made in the letter by Greenhalgh and colleagues,3 of which I am a signatory. On the risks of attempting herd immunity, even if we optimistically assume that immunity would persist after infection and that vulnerable people can really be shielded, infecting, say, half of the 35 million younger people (20-59 …
Abstract 15804: Characteristics and Prognosis of Patients Hospitalized With Heart Failure With Mid-Range Ejection Fraction
Authors: Cheng Chen, Derek Phan, Rikin Tank, David Wee, Lewei Duan, Ming Sum Lee
Journal: Circulation (2019)

Background and Objectives: There are limited data regarding the prognosis of patients with heart failure with mid-range left ventricular ejection fraction (LVEF 40-50%). The goal of this study is t...
Quality assurance and characterization of narrowband ultraviolet B devices for use at home: lessons from the HI‐Light Vitiligo Trial
Authors: A. Rogers, P. Akram, J.M. Batchelor, J. Crutchley, M. Grocki, R.H. Haines, G. Meakin, K. O’Dowd, J. Ravenscroft, K.S. Thomas
Journal: British Journal of Dermatology (2020)
Why I . . . ride a motorcycle
Authors: Francesca Robinson
Journal: BMJ (2020)

Andrew Coe is known for avoiding excessive risks at work but in his free time he rides motorcycles-one of the most dangerous ways of travelling by road (per mile travelled, the risk of death for a motorcyclist is at least 57 times higher than that for a car occupant). 1"Riding a motorcycle is extremely hazardous but it's great fun," he says.Coe's passion for motorcycles was kindled in childhood; his father and brother rode them and his uncle owned a motorbike shop.He has ridden since he was 17.A pile-up that he experienced aged 21, however, as well as the responsibilities of having a family, deterred him from riding in his middle years.
Redoubling Efforts to Help Americans Quit Smoking — Federal Initiatives to Tackle the Country’s Longest-Running Epidemic
Authors: Robert R. Redfield, Stephen M. Hahn, Norman E. Sharpless
Journal: New England Journal of Medicine (2020)

Redoubling Efforts to Help Americans Quit Smoking Because the smoking rate among adults has fallen, and because smoking can be overshadowed by other public health issues, it’s possible to overlook ...
Decisions Ahead of Time: The Power of Guidelines to Change Opioid Prescribing in Today’s World
Authors: Maria A. Woodward, Jennifer Waljee
Journal: Ophthalmology (2020)

More opioid prescriptions are dispensed in the United States than any other country.1 Unused pills that linger in medicine cabinets often lead to misuse disorders by patients or others. Ophthalmologists prescribe opioids, but the extent of our prescribing and its effect on communities are unclear. Analyzing a Medicare dataset, Patel and Sternberg2 showed that ophthalmologists wrote prescriptions for short time durations (mean of 5 days) and in low volumes (mean of 7 prescriptions annually). But when analyzing slightly younger, privately insured patients, Kolomeyer et al3 found that ophthalmologists' prescribing has risen over time with twice the number of opioid prescriptions written from 2000 to 2014.
Covid-19: Most trainees have faced disruption to their training, GMC survey shows
Authors: Abi Rimmer
Journal: BMJ (2020)

We present the case of a patient who presented with worsening chest pain and tachycardia. We were able to monitor her remotely through her pacemaker. She had been started on the injectable medication teriparatide (Forteo) and since then she had an increase in her symptoms. She was found to have intermittent atrial tachycardia with 1:1 conduction and occasional atrioventricular block transiently, coinciding with her injection of teriparatide. This specific-associated arrhythmia has yet to be described.
Association of State Stay-at-Home Orders and State-Level African American Population With COVID-19 Case Rates
Authors: Sangeetha Padalabalanarayanan, Vidya Sagar Hanumanthu, Bisakha Sen
Journal: JAMA Network Open (2020)

To cope with the continuing coronavirus disease 2019 (COVID-19) pandemic, state and local officials need information on the effectiveness of policies aimed at curbing disease spread, as well as state-specific characteristics, like the racial mix, associated with increased risks related to the disease.
Dengue fever among U.S. travelers returning from the Dominican Republic - Minnesota and Iowa, 2008.
Authors: D. Neitzel, R. Fisher, K. Crimmings, S. Brend, M. Hobson, C. L. Perez-Guerra, E. Zielinski-Gutierrez, J. E. Staples
Journal: MMWR Morbidity and Mortality Weekly Report (2010)
Importance of nutrition in football: the coach’s perspective
Authors: Arsène Wenger
Journal: British Journal of Sports Medicine (2020)

We often hear from the scientific community of the importance of sports science within football, but too often the voices of coaches are not heard in the best practice guidelines, when they could offer valuable insight. The goal of any elite team is high performance—to win as many matches as possible over the duration of the season. There are myriad factors involved in the achievement of such performance, including technical, tactical, mental and physical qualities. One area that I have emphasised for many years (as early as the 1980s) that can help us achieve our performance goals is nutrition, an area that has grown in importance within the game. For the coach, nutrition has the following objectives within the performance model:

1.  To ensure that players are in prime physical condition for each match, with optimal levels of body fat and muscle mass.

2.  To accelerate recovery following a match or a hard training session.

3.  To ensure that players are adequately fuelled and have the energy required …
TCT CONNECT-347 Overexpansion of Balloon-Expandable Aortic Transcatheter Heart Valves in the Mitral Valve Position
Authors: Mohammed Al-Hijji, Mackram Eleid, Dee Dee Wang, Susheel Kodali, Tatiana Kaptzan, Abdallah El Sabbagh, Jae Oh, William O'Neill, Chet Rihal, Mayra Guerrero
Journal: Journal of the American College of Cardiology (2020)
TCT CONNECT-268 Safety and Performance of the Resorbable Magnesium Scaffold, Magmaris in a Real-World Setting—NSTEMI, Diabetes, and B2/C Lesion Subgroups Analyses of the First Cohort Subjects at 12-Month Follow-up of the BIOSOLVE-IV Registry
Authors: Adrian Wlodarczak, Gregory Starmer, Jan Torzewski, Johan Bennett, Marcus Wiemer, Michael Nguyen, Manel Sabate, René Van der Schaaf, Piero Montorsi, Eric Eeckhout, Michael Kang-Yin Lee, Stefan Verheye
Journal: Journal of the American College of Cardiology (2020)
Cost-effectiveness analysis of SARS-CoV-2 infection prevention strategies including pre-endoscopic virus testing and use of high risk personal protective equipment
Authors: Alanna Ebigbo, Christoph Römmele, Christina Bartenschlager, Selin Temizel, Elisabeth Kling, Jens Brunner, Helmut Messmann
Journal: Endoscopy (2020)

Infection prevention strategies to protect healthcare workers in endoscopy units during the post-peak phase of the COVID-19 pandemic are currently under intense discussion. In this paper, the cost-effectiveness of routine pre-endoscopy testing and high risk personal protective equipment (PPE) is addressed.A model based on theoretical assumptions of 10 000 asymptomatic patients presenting to a high volume center was created. Incremental cost-effectiveness ratios (ICERs) and absolute costs per endoscopy were calculated using a Monte Carlo simulation.ICER values for universal testing decreased with increasing prevalence rates. For higher prevalence rates (≥ 1 %), ICER values were lowest for routine pre-endoscopy testing coupled with use of high risk PPE, while cost per endoscopy was lowest for routine use of high risk PPE without universal testing.In general, routine pre-endoscopy testing combined with high risk PPE becomes more cost-effective with rising prevalence rates of COVID-19.
Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses
Authors: Jenna J. Guthmiller, Linda Yu-Ling Lan, Monica L. Fernández-Quintero, Julianna Han, Henry A. Utset, Dalia J. Bitar, Natalie J. Hamel, Olivia Stovicek, Lei Li, Micah Tepora, Carole Henry, Karlynn E. Neu, Haley L. Dugan, Marta T. Borowska, Yao-Qing Chen, Sean T.H. Liu, Christopher T. Stamper, Nai-Ying Zheng, Min Huang, Anna-Karin E. Palm, Adolfo García-Sastre, Raffael Nachbagauer, Peter Palese, Lynda Coughlan, Florian Krammer, Andrew B. Ward, Klaus R. Liedl, Patrick C. Wilson
Journal: Immunity (2020)

Polyreactivity is the ability of a single antibody to bind to multiple molecularly distinct antigens and is a common feature of antibodies induced upon pathogen exposure. However, little is known about the role of polyreactivity during anti-influenza virus antibody responses. By analyzing more than 500 monoclonal antibodies (mAbs) derived from B cells induced by numerous influenza virus vaccines and infections, we found mAbs targeting conserved neutralizing influenza virus hemagglutinin epitopes were polyreactive. Polyreactive mAbs were preferentially induced by novel viral exposures due to their broad viral binding breadth. Polyreactivity augmented mAb viral binding strength by increasing antibody flexibility, allowing for adaption to imperfectly conserved epitopes. Lastly, we found affinity-matured polyreactive B cells were typically derived from germline polyreactive B cells that were preferentially selected to participate in B cell responses over time. Together, our data reveal that polyreactivity is a beneficial feature of antibodies targeting conserved epitopes.
TCT CONNECT-476 Self-Expandable Valves and Aortic Angulation Adversely Impact Transcatheter Aortic Valve Replacement Outcomes
Authors: Anees Musallam, Toby Rogers, Chava Chezar-Azerrad, Brian Case, Charan Yerasi, Brian Forrestal, Corey Shea, Cheng Zhang, Nauman Khalid, Jaffar Khan, Lowell Satler, Itsik Ben-Dor, Ron Waksman
Journal: Journal of the American College of Cardiology (2020)
TCT CONNECT-51 Early Invasive Therapy Versus Ischemia-Guided Therapy in Older Adults With Non–ST-Segment Elevation Acute Coronary Syndromes: An Updated Meta-Analysis
Authors: Neel Bhan, Mahin Khan, Nauman Khalid, Mirza Khalid, Waleed Kayani
Journal: Journal of the American College of Cardiology (2020)
TCT CONNECT-86 Transcatheter Aortic Valve Replacement With the LOTUS Edge System: Early European Experience
Authors: Xavier Armario, Liesbeth Rosseel, Rajesh Kharbanda, Saib Khogali, Mohamed Abdel-Wahab, Nicolas Van Mieghem, Didier Tchetche, Nicolas Dumonteil, Ole De Backer, James Cotton, Brian McGrath, Deepu Balakrishnan, Noman Ali, Serdar Farhan, Jubin Joseph, Gaétan Charbonnier, Taishi Okuno, Fiachra McHugh, David Hildick-Smith, Nicole Gilgen, Christian Frerker, Marco Angelillis, Marek Grygier, James Cockburn, Henrik Bjursten, Rui Teles, Anna Sonia Petronio, Thomas Pilgrim, Jan-Malte Sinning, Georg Nickenig, Lars Sondergaard, Darren Mylotte
Journal: Journal of the American College of Cardiology (2020)
Continuing Prednisone Offers Stable Rheumatoid Arthritis Control
Authors: Anita Slomski
Journal: JAMA (2020)

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TCT CONNECT-102 Early Recovery of Left Ventricular Systolic Function After Transcatheter Aortic Valve Implantation
Authors: Maria Drakopoulou, Stergios Soulaidopoulos, George Oikonomou, Alexandrina Kouroutzoglou, Pantelis Toskas, Konstantinos Stathogiannis, Maria Xanthopoulou, Andreas Synetos, George Latsios, Angelos Papanikolaou, Skevos Sideris, Dimitrios Tousoulis, Konstantinos Toutouzas
Journal: Journal of the American College of Cardiology (2020)
TCT CONNECT-284 Intravascular Ultrasound Radiofrequency Signal Analysis for Simultaneous Assessment of Functional Significance and Structural Abnormality of Intermediate Coronary Artery Lesions
Authors: Kuninobu Kashiyama, Kozo Okada, Kensuke Matsushita, Kiyoshi Hibi, M. Brooke Hollak, Paul Yock, Alan C. Yeung, Peter J. Fitzgerald, Yasuhiro Honda
Journal: Journal of the American College of Cardiology (2020)
TCT CONNECT-71 Outcomes of Urgent/Emergent Endovascular Transcatheter Aortic Valve Replacement in Bicuspid Aortic Valve Stenosis
Authors: Keerat Rai Ahuja, Salik Nazir, Toshiaki Isogai, Anas Saad, Moshrik Abd Alamir, Shashank Shekhar, Omar Abdelfattah, James Yun, Grant Reed, Rishi Puri, Amar Krishnaswamy, Samir Kapadia
Journal: Journal of the American College of Cardiology (2020)