Improvement in Polymyalgia Rheumatica Associated With Improved Control of Diabetes Mellitus: A Case Series
Authors: Ken Yoshida, Noriko Sakamoto, Daitaro Kurosaka
Journal: Annals of Internal Medicine (2020)

LettersFebruary 2021Improvement in Polymyalgia Rheumatica Associated With Improved Control of Diabetes Mellitus: A Case SeriesKen Yoshida, MD, PhD, Noriko Sakamoto, MD, and Daitaro Kurosaka, MDKen Yoshida, MD, PhDThe Jikei University School of Medicine, Tokyo, Japan (K.Y., N.S., D.K.), Noriko Sakamoto, MDThe Jikei University School of Medicine, Tokyo, Japan (K.Y., N.S., D.K.), and Daitaro Kurosaka, MDThe Jikei University School of Medicine, Tokyo, Japan (K.Y., N.S., D.K.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L20-0196 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Polymyalgia rheumatica, a chronic inflammatory condition affecting elderly persons, is characterized by severe pain and stiffness, occurring mostly in the shoulders, upper arms, and pelvic girdle. We frequently encounter patients with both polymyalgia rheumatica and type 2 diabetes mellitus, but the association between these 2 diseases remains to be clarified.Objective: To raise the possibility that some patients with polymyalgia rheumatica and type 2 diabetes mellitus can avoid glucocorticoid treatment.Case Report 1: We took care of a 68-year-old man with bilateral shoulder pain and morning stiffness. He had been using nonsteroidal anti-inflammatory drugs (NSAIDs) without effect for 6 ...References1. Chuang TY, Hunder GG, Ilstrup DM; et al. Polymyalgia rheumatica: a 10-year epidemiologic and clinical study. Ann Intern Med. 1982;97:672-80 LinkGoogle Scholar2. Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol. 2011;11:98-107. [PMID: 21233852] doi:10.1038/nri2925 CrossrefMedlineGoogle Scholar3. Yanai H, Kaneko H, Yoshida H; et al. A significant association between impaired glucose metabolism and polymyalgia rheumatica [Letter]. J Atheroscler Thromb. 2010;17:1108-9. [PMID: 20693748] CrossrefMedlineGoogle Scholar4. Samson M, Audia S, Fraszczak J; et al. Th1 and Th17 lymphocytes expressing CD161 are implicated in giant cell arteritis and polymyalgia rheumatica pathogenesis. Arthritis Rheum. 2012;64:3788-98. [PMID: 22833233] doi:10.1002/art.34647 CrossrefMedlineGoogle Scholar5. Qiao YC, Shen J, He L; et al. Changes of regulatory T cells and of proinflammatory and immunosuppressive cytokines in patients with type 2 diabetes mellitus: a systematic review and meta-analysis. J Diabetes Res. 2016;2016:3694957. [PMID: 27777959] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: The Jikei University School of Medicine, Tokyo, Japan (K.Y., N.S., D.K.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L20-0196.Corresponding Author: Ken Yoshida, MD, PhD, Division of Rheumatology, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-shimbashi, Minato-ku, Tokyo 105-8461, Japan; e-mail, k.[email protected]ac.jp.This article was published at Annals.org on 15 September 2020. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAnnals On Call - Polymyalgia Rheumatica and Giant Cell Arteritis Robert M. Centor and Sebastian E. Sattui Cortes Metrics Cited byClinical analysis of gender and pre-existing diabetes mellitus in patients with polymyalgia rheumatica: A retrospective study in a Japanese populationDipeptidyl peptidase-4 inhibitor use is associated with a lower erythrocyte sedimentation rate in patients with remitting seronegative symmetrical synovitis with pitting oedema and pre-existing diabetes mellitusFunctionally Heterogenous Macrophage Subsets in the Pathogenesis of Giant Cell Arteritis: Novel Targets for Disease Monitoring and Treatment February 2021Volume 174, Issue 2Page: 274-276KeywordsC-reactive proteinsGlucoseHbA1cHipNSAIDsPolymyalgia rheumaticaResearch laboratoriesShouldersStiffnessType 2 diabetes ePublished: 15 September 2020 Issue Published: February 2021 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...