tbuckley/cabot-search huggingface dataset:
Clinical Characteristics and Risk Factors for Mortality of COVID-19 Patients With Diabetes in Wuhan, China: A Two-Center, Retrospective Study
Authors: Qiao Shi, Xiaoyi Zhang, Fang Jiang, Xuanzhe Zhang, Ning Hu, Chibu Bimu, Jiarui Feng, Su Yan, Yongjun Guan, Dongxue Xu, Guangzhen He, Chen Chen, Xingcheng Xiong, Lei Liu, Hanjun Li, Jing Tao, Zhiyong Peng, Weixing Wang
Journal: Diabetes Care (2020)

OBJECTIVE Diabetes is common in COVID-19 patients and associated with unfavorable outcomes. We aimed to describe the characteristics and outcomes and to analyze the risk factors for in-hospital mortality of COVID-19 patients with diabetes. RESEARCH DESIGN AND METHODS This two-center retrospective study was performed at two tertiary hospitals in Wuhan, China. Confirmed COVID-19 patients with diabetes (N = 153) who were discharged or died from 1 January 2020 to 8 March 2020 were identified. One sex- and age-matched COVID-19 patient without diabetes was randomly selected for each patient with diabetes. Demographic, clinical, and laboratory data were abstracted. Cox proportional hazards regression analyses were performed to identify the risk factors associated with the mortality in these patients. RESULTS Of 1,561 COVID-19 patients, 153 (9.8%) had diabetes, with a median age of 64.0 (interquartile range 56.0–72.0) years. A higher proportion of intensive care unit admission (17.6% vs. 7.8%, P = 0.01) and more fatal cases (20.3% vs. 10.5%, P = 0.017) were identified in COVID-19 patients with diabetes than in the matched patients. Multivariable Cox regression analyses of these 306 patients showed that hypertension (hazard ratio [HR] 2.50, 95% CI 1.30–4.78), cardiovascular disease (HR 2.24, 95% CI 1.19–4.23), and chronic pulmonary disease (HR 2.51, 95% CI 1.07–5.90) were independently associated with in-hospital death. Diabetes (HR 1.58, 95% CI 0.84–2.99) was not statistically significantly associated with in-hospital death after adjustment. Among patients with diabetes, nonsurvivors were older (76.0 vs. 63.0 years), most were male (71.0% vs. 29.0%), and they were more likely to have underlying hypertension (83.9% vs. 50.0%) and cardiovascular disease (45.2% vs. 14.8%) (all P values &amp;lt;0.05). Age ≥70 years (HR 2.39, 95% CI 1.03–5.56) and hypertension (HR 3.10, 95% CI 1.14–8.44) were independent risk factors for in-hospital death of patients with diabetes. CONCLUSIONS COVID-19 patients with diabetes had worse outcomes compared with the sex- and age-matched patients without diabetes. Older age and comorbid hypertension independently contributed to in-hospital death of patients with diabetes.
EVAC THERAPY FOR RECTAL ANASTOMOTIC LEAKS AND PERFORATION
Authors: G Grande, A Caruso, H Bertani, G Masciangelo, S Russo, F Pigò, S Cocca, F Morando, L Avallone, R Conigliaro
Journal: Endoscopy (2020)

Aims Rectal perforation and anastomotic leaks or fistula occurring after colorectal surgery are difficult to treat situation burdened by considerable morbidity, costs and highly stressful for the patient. The incidence of anastomotic leakage reaches 24%of patients undergoing colorectal surgery. Near a quarter of these result in a permanent intestinal stoma. Small leakages are usually managed endoscopically. However, in most of cases diagnosis is delayed and leakages are wider, leading to perineal collection with possible serious complications requiring invasive procedure and surgical re-intervention. In this patients, endovac therapy (Endo-SPONGE; B. Braun Medical) represents a minimally invasive option to treat post surgical leak or rectal traumatic perforation
Measurement properties of the Patient‐Reported Outcomes Information System (PROMIS<sup>®</sup>) Itch Questionnaire: itch severity assessments in adults with atopic dermatitis*
Authors: J.I. Silverberg, J.‐S. Lai, K.R. Patel, V. Singam, P.P. Vakharia, R. Chopra, R. Sacotte, R. Kantor, D.Y. Hsu, D. Cella
Journal: British Journal of Dermatology (2020)

Little is known about the validity of numeric rating scales (NRS) and verbal rating scales (VRS) for itch and itch frequency for assessing itch severity in atopic dermatitis (AD). We evaluated the Patient-Reported Outcomes Information System (PROMIS® ) Itch Questionnaire (PIQ) - itch severity assessment, including multiple NRS, VRS and frequency of itch assessments, in adults with AD and compared their performance.Self-administered questionnaires and skin examinations were performed in 410 patients with AD (aged 18-90 years) in a dermatology practice setting.PIQ NRS, VRS and frequency of itch had good content validity, strong correlations with one another (Spearman correlations P < 0·001) and weak-to-moderate correlations with patient-oriented eczema measure (POEM), Eczema Area and Severity Index (EASI), objective SCORing AD (SCORAD) and Dermatology Life Quality Index (DLQI) (P < 0·001) and very good discriminant validity. Changes from baseline in NRS, VRS and frequency of itch were moderately to strongly correlated with one another, and weakly to moderately correlated with other patient-reported (POEM, SCORAD itch, DLQI) and clinician-reported outcomes (EASI, objective SCORAD). NRS and VRS worst itch and average itch showed moderate-to-good test-retest reliability. There were no floor or ceiling effects for NRS or VRS itch, but there were ceiling effects for itch frequency. Each assessment was completed in < 1 min by all patients.NRS, VRS and frequency of itch items from PIQ - itch severity showed good content and construct validity, reliability, and/or responsiveness in adults with AD, and were feasible for use in clinical trials and practice. What is already known about this topic? Numeric rating scales (NRS), verbal rating scales (VRS) and frequency of itch have been used to assess the burden of itch. However, there have been limited results demonstrating their validity, responsiveness, interpretability and feasibility, particularly in atopic dermatitis (AD). What does this study add? This study demonstrated that NRS, VRS and frequency of itch items from the Patient-Reported Outcomes Information System (PROMIS® ) Itch Questionnaire (PIQ) - itch severity assessments had good construct validity, responsiveness, reliability and feasibility in the assessment of adult AD. PIQ NRS, VRS and frequency of itch all appear to have sufficient validity, reliability and feasibility for use as assessments of itch in adults with AD in clinical practice and trials. What are the clinical implications of this work? PIQ NRS and VRS are all simple, valid, reliable and feasible for use in clinical practice and trials to assess itch in adults with AD. Linked Comment: Oosterhaven. Br J Dermatol 2020; 183:802-803.
Covid-19: Testing testing
Authors: Fiona Godlee
Journal: BMJ (2020)

The physiological demands of rugby league are complex, requiring players to concomitantly develop speed, agility, muscular strength, power and aerobic capacity. Studies indicate that injury rates are higher in rugby league than other collision sports. The incidence of injury in semiprofessional rugby league players has been reported to be as high as 825 per 1000 player-position game hours. Sports teams with a common epidemiology of injuries often undertake musculoskeletal preparticipation screening (MPPS) in an attempt to reduce the incidence of these injuries. The aim of this study was to undertake a general MPPS for a Super 8 BUCS Rugby League team. 30 players volunteered to undertake a MPPS at the start of preseason training. The MPPS consisted of 10 assessments including (1) single-leg supine bridge hold (transversus abdominis stability), (2) straight leg raise (hamstring flexibility) (3) modified Thomas test (abductor, iliopsoas and rectus femoris contracture), (4) gluteus maximus and hamstring muscle recruitment for hip extension, (5) manual muscle test of gluteus medius and minimus, (6) plumbline assessment of standing posture, (7) Trendelenburg test, (8) overhead squat with shoulder width grip, (9) in-line lunge and (10) single-leg squat. Results showed a prevalence of poor physical preparedness. All subjects were deficient in transversus abdominis, gluteus medius and single-leg strength. All subjects were hypertonic in hip abductors, iliopsoas and hamstrings. All subjects recruited hamstrings before gluteus maximus for hip extension. None of the subjects could perform a single-leg squat, nor achieve all of the competencies required in the overhead squat. All subjects demonstrated shoulder protraction in standing posture. A prehabilitation programme was implemented for all players after assessment with modifications to strength and conditioning programmes.
The European Society of Gastrointestinal Endoscopy Quality Improvement Initiative: developing performance measures
Authors: Matthew Rutter, Carlo Senore, Raf Bisschops, Dirk Domagk, Roland Valori, Michal Kaminski, Cristiano Spada, Michael Bretthauer, Cathy Bennett, Cristina Bellisario, Silvia Minozzi, Cesare Hassan, Colin Rees, Mário Dinis-Ribeiro, Tomas Hucl, Thierry Ponchon, Lars Aabakken, Paul Fockens
Journal: Endoscopy (2015)

The European Society of Gastrointestinal Endoscopy (ESGE) and United European Gastroenterology (UEG) have a vision to create a thriving community of endoscopy services across Europe, collaborating with each other to provide high quality, safe, accurate, patient-centered and accessible endoscopic care. Whilst the boundaries of what can be achieved by advanced endoscopy are continually expanding, we believe that one of the most fundamental steps to achieving our goal is to raise the quality of everyday endoscopy. The development of robust, consensus- and evidence-based key performance measures is the first step in this vision. ESGE and UEG have identified quality of endoscopy as a major priority. This paper explains the rationale behind the ESGE Quality Improvement Initiative and describes the processes that were followed. We recommend that all units develop mechanisms for audit and feedback of endoscopist and service performance using the ESGE performance measures that will be published in future issues of this journal over the next year. We urge all endoscopists and endoscopy services to prioritize quality and to ensure that these performance measures are implemented and monitored at a local level, so that we can provide the highest possible care for our patients.
Combined Prednisone and Mycophenolate Mofetil Treatment for Retroperitoneal Fibrosis
Authors: Paul J. Scheel, Nancy Feeley, Stephen M. Sozio
Journal: Annals of Internal Medicine (2011)

In this series, 28 patients with retroperitoneal fibrosis received prednisone, 40 mg/d, tapered over 6 months, and mycophenolate mofetil, 1000 mg twice daily, for a mean of 24.3 months. Systemic sy...
OBSTRUCTIVE COLON CANCERS AT ENDOSCOPY ARE ASSOCIATED WITH ADVANCED TUMOR STAGE AND POOR PATIENT OUTCOME
Authors: F Abu Baker, O Gal, B Ovadia, M Ganayem, R Taher, A Mari, A Beshara, Y Kopelman
Journal: Endoscopy (2020)

Aims It is still debatable whether a colorectal cancer tumor size affects patients´ prognosis and outcome. A more clinically relevant and frequently encountered scenario is the presence of subclinical obstructive mass during endoscopic exam hindering the passage of endoscope and precluding complete exam. The significance and implications of this finding were not fully investigated, and will be addressed in this study.
ENDOSCOPIC ULTRASOUND USING A SINGLE TYPE 22 GA NEEDLE FOR PANCREATIC LESIONS WITHOUT ROSE: A SINGLE CENTER, SINGLE OPERATOR RETROSPECTIVE STUDY
Authors: E Rinja, M Ilie, V Sandru, O Plotogea, D Vascu, V Ionescu, R Plescuta, A Butuc, G Constantinescu
Journal: Endoscopy (2020)

Aims Endoscopic ultrasound with fine needle aspiration (EUS with FNA) has proven to be the gold standard in establishing the hystopathological diagnosis for prior hard to reach lesions using conventional methods. The aim of our study is to compare the diagnostic accuracy between the EUS findings and the hystopathological diagnosis using a single type of needle in pancreatic lesions.
ENDOSCOPIC ULTRASOUND-FINE NEEDLE ASPIRATION (EUS-FNA) DIAGNOSTIC ACCURACY IN THE EVALUATION OF PANCREATIC NEUROENDOCRINE NEOPLASMS (PNEN) GRADING
Authors: M Tacelli, MC Petrone, G Capurso, G Rossi, L Archibugi, S Testoni, F Muffatti, S Partelli, C Doglioni, M Falconi, PG Arcidiacono
Journal: Endoscopy (2020)

Aims Prognosis of pNENs depends on staging and grading, which is based on the cyto-histological Ki67 labelling. EUS-FNA is considered the gold standard technique to obtain a cytological specimen in pre-therapeutic setting that can be used to evaluate ki67. The aim of this study was to establish the diagnostic accuracy of preoperative EUS-FNA Ki67 evaluation in a cohort of pNEN patients.
TREATMENT OF LARGE MAIN BILE DUCT STONES IN A PATIENT WITH 4/5 GASTRECTOMY AND ROUX-EN-Y ANASTOMOSIS USING ANTEROGRADE CHOLANGIOSCOPY AND ELECTOHYDRAULIC LITHOTRIPSY AFTER HEPATICOGASTROSTOMY
Authors: M Schaefer, A Lamoureux, H Chanty, W Yacoub, V Laurent, S Naudé, A Ayav, J-B Chevaux
Journal: Endoscopy (2020)

Treatment of benign biliary obstruction is a challenging situation in patients with altered anatomy. ERCP with single or double balloon enteroscopy can be difficult, with an overall cannulation success of about 60%. We describe the case of a 86-years old women with history of 4/5 gastrectomy and Roux-en-Y anastomosis and main bile duct symptomatic lithiasis, with failure of two enteroscopies. After performing hepaticogastrostomy, we performed an anterograde electrohydraulic lithotripsy using an ultraslim videogastroscope as a cholangioscope. A guidewire was placed during cholangioscopy to place a transpapillary biliary metallic stent to enable complete biliary stones clearance.
POEM FOR TREATMENT OF ACHALASIA WITH NORMAL ESOPHAGOGASTRIC JUNCTION RELAXATION
Authors: V Kaibysheva, E Fedorov, S Shapovaliantc
Journal: Endoscopy (2020)

Aims Manometric criteria of achalasia are absent peristalsis and incomplete relaxation of the esophagogastric junction (EGJ). We have experienced patients with clinical and radiological features of achalasia with normal integrated relaxation pressure (IRP< 15 mm Hg). The aim of the study was to assess effectiveness of peroral endoscopic myotomy (POEM) for treatment patients who are not fulfilling the Chicago Classification scriteria of achalasia.
Covid-19 and alcohol—a dangerous cocktail
Authors: Ilora Finlay, Ian Gilmore
Journal: BMJ (2020)

The principal aim of this work was to better understand how regenerating muscle fibers become innervated in adult animals. To induce muscle regeneration, individual identified muscle fibers in a mouse were damaged with a laser focused through a microscope. The muscle fiber that degenerated and the muscle fiber that was formed in its place were followed by viewing the same site repeatedly over a period of 2 d to 40 weeks. Commonly, the nerve terminal innervating the irradiated muscle fiber partially retracted during muscle fiber degeneration, and then sprouted to innervate the regenerating muscle fiber at the same site it had previously innervated the muscle fiber that was damaged. During the early phase of muscle regeneration we also observed sprouts originating from nerve terminals on adjacent muscle fibers. The new nerve growth was a response to the regenerating muscle fiber rather than to the degenerated fiber it replaced because repeated damage of the same site every 2–3 d over a 10 d period (to prevent regeneration) did not cause any sprouting. The direction of the sprouts on adjacent muscle fibers showed a bias toward the regenerating muscle fiber, although they avoided the region occupied by the original nerve terminal. Forty percent of the sprouts managed to reach the regenerated fiber. Nonetheless, by 11 d after muscle fiber damage, all sprouts had regressed, leaving the new fiber innervated by the same motor axon that innervated the fiber that was damaged. On the other hand, when the overlying nerve terminal as well as the muscle fiber was damaged, the sprouts from nearby muscle fibers were both more numerous and more stable, and in five cases we observed two or more new synaptic junctions on the regenerating fiber originating from different axons. In one case we witnessed a protracted competition between the original motor axon as it sprouted back and the sprouts from nearby junctions for sole innervation of the regenerate. Ultimately, the surviving sprouts myelinated and became the permanent and exclusive input to the new fiber. These results indicate that regenerating muscle fibers emit a signal that induces directional sprouting from nearby undamaged nerve terminals. Reinnervation of the regenerating muscle fiber by one axon apparently prevents the maintenance of such neurites. Because the process of muscle regeneration shares many features in common with myogenesis during embryonic development, it is likely that developing muscle fibers present an analogous stimulus to ingrowing motor axons.(ABSTRACT TRUNCATED AT 400 WORDS)
Dosimetric evaluation of radionuclides for VCAM-1-targeted radionuclide therapy in an early brain metastasis model
Authors: K A Vallis, N Falzone, N L Ackerman, L de la Fuente Rosales, M Bernal, X Liu, Peeters Sgja., M Sarmiento Soto, A Corroyer-Dulmont, M Bernaudin, E Grimoin, O Touzani, N R Sibson
Journal: Theranostics (2018)
ENDOSCOPIC RECURRENCE AFTER ILEOCAECAL RESECTION FOR CROHN´S DISEASE RELATING TO MICROSCOPIC INFLAMMATION AT RESECTION MARGINS
Authors: L Kunovsky, K Poredska, F Marek, Z Kala, V Prochazka, J Dolina, V Zboril, R Kroupa, J Vaculova, T Pavlik, J Vlazny, P Jabandziev, D Ivanecka, L Mitas
Journal: Endoscopy (2020)

Aims An early postoperative endoscopic recurrence of Crohn´s disease after ileocaecal resection remains unclear concerning its pathogenesis and risk factors. In our study, we evaluated the influence of histological inflammation at the resection margins on endoscopic recurrence.
Direct oral anticoagulants for cancer-associated venous thromboembolism: a systematic review and meta-analysis
Authors: Frits I. Mulder, Floris T. M. Bosch, Annie M. Young, Andrea Marshall, Robert D. McBane, Tyler J. Zemla, Marc Carrier, Pieter Willem Kamphuisen, Patrick M. M. Bossuyt, Harry R. Büller, Jeffrey I. Weitz, Saskia Middeldorp, Nick van Es
Journal: Blood (2020)
RISK OF LYMPH NODE METASTASIS IN PT1SM2 COLORECTAL CARCINOMA: RESULTS OF BICENTRIC RETROSPECTIVE STUDY
Authors: J Winkler, JP Ratone, A Lupu, E Bories, F Caillol, C Pesenti, C Zemmour, H Meillat, F Poizat, V Hervieu, T Ponchon, J Rivory, B Lelong, C Dechaisemartin, M Giovannini, M Pioche
Journal: Endoscopy (2020)

Primary: Evaluate the recurrence-free survival rate in all patients and in pre-defined subgroups at 12 and 18 months.
CONTRIBUTION OF ENDOSCOPY IN THE EXPLORATION OF ANEMIA IN CIRRHOTIC PATIENTS
Authors: S Bradai, I Akkari, S Mrabet, EB Jazia
Journal: Endoscopy (2020)

Aims The occurrence of anemia during cirrhosis is common. Its prevalence varies from 40 to 70% according to the literature. The aim of this study was to determine the Contribution of endoscopy in the exploration of anemia in cirrhotic patients.
Association Between Treatment With Apixaban, Dabigatran, Rivaroxaban, or Warfarin and Risk for Osteoporotic Fractures Among Patients With Atrial Fibrillation
Authors: Wallis C.Y. Lau, Ching-Lung Cheung, Kenneth K.C. Man, Esther W. Chan, Chor Wing Sing, Gregory Y.H. Lip, Chung-Wah Siu, Joanne K.Y. Lam, Alan C.H. Lee, Ian C.K. Wong
Journal: Annals of Internal Medicine (2020)

It is unclear whether anticoagulant type is associated with the risk for osteoporotic fracture, a deleterious complication of anticoagulants among patients with atrial fibrillation (AF).To compare the risk for osteoporotic fracture between anticoagulants.Population-based cohort study.Territory-wide electronic health record database of the Hong Kong Hospital Authority.Patients newly diagnosed with AF between 2010 and 2017 who received a new prescription for warfarin or a direct oral anticoagulant (DOAC) (apixaban, dabigatran, or rivaroxaban). Follow-up ended on 31 December 2018.Osteoporotic hip and vertebral fractures in anticoagulant users were compared using propensity score-weighted cumulative incidence differences (CIDs).There were 23 515 patients identified (3241 apixaban users, 6867 dabigatran users, 3866 rivaroxaban users, and 9541 warfarin users). Overall mean age was 74.4 years (SD, 10.8), ranging from 73.1 years (warfarin) to 77.9 years (apixaban). Over a median follow-up of 423 days, 401 fractures were identified (crude event number [weighted rate per 100 patient-years]: apixaban, 53 [0.82]; dabigatran, 95 [0.76]; rivaroxaban, 57 [0.67]; and warfarin, 196 [1.11]). After 24-month follow-up, DOAC use was associated with a lower risk for fracture than warfarin use (apixaban CID, -0.88% [95% CI, -1.66% to -0.21%]; dabigatran CID, -0.81% [CI, -1.34% to -0.23%]; and rivaroxaban CID, -1.13% [CI, -1.67% to -0.53%]). No differences were seen in all head-to-head comparisons between DOACs at 24 months (apixaban vs. dabigatran CID, -0.06% [CI, -0.69% to 0.49%]; rivaroxaban vs. dabigatran CID, -0.32% [CI, -0.84% to 0.18%]; and rivaroxaban vs. apixaban CID, -0.25% [CI, -0.86% to 0.40%]).Residual confounding is possible.Among patients with AF, DOAC use may result in a lower risk for osteoporotic fracture compared with warfarin use. Fracture risk does not seem to be altered by the choice of DOAC. These findings may help inform the benefit-risk assessment when choosing between anticoagulants.The University of Hong Kong and University College London Strategic Partnership Fund.
Infographic. Running myth: switching to a non-rearfoot strike reduces injury risk and improves running economy
Authors: James L N Alexander, Richard W Willy, Christopher Napier, Daniel R Bonanno, Christian J Barton
Journal: British Journal of Sports Medicine (2020)

Endurance running is associated with high rates of injury,1 with injury causation often complex and multifactorial.2 Running biomechanics are thought to play a role in the aetiology of running-related injury.3 Therefore interventions to change running technique may assist in the prevention and management of injuries.4

The overwhelming majority of recreational shod distance runners run with a rearfoot strike pattern.5 Running with a rearfoot strike has been retrospectively associated with greater risk of running-related injury,6 and switching to a non-rearfoot strike pattern has been reported to improve symptoms in runners with anterior lower leg pain and patellofemoral pain.7 8 As such, changing strike pattern has become a commonly considered and promoted strategy when attempting to prevent and manage injury in endurance runners9 (see figure 1). Many elite …