Cross-Sex Hormones and Acute Cardiovascular Events in Transgender Persons
Authors: Zil Goldstein, Carl Streed, Tamar Resiman, Monica Mukherjee, Asa Radix
Journal: Annals of Internal Medicine (2019)

Letters15 January 2019Cross-Sex Hormones and Acute Cardiovascular Events in Transgender PersonsZil Goldstein, FNP-BC, Carl Streed, MD, MPH, Tamar Resiman, MD, Monica Mukherjee, MD, MPH, and Asa Radix, MD, MPHZil Goldstein, FNP-BCCenter for Transgender Medicine and Surgery Mount Sinai Health System, New York, New York (Z.G.), Carl Streed, MD, MPHBoston University School of Medicine, Boston, Massachusetts (C.S.), Tamar Resiman, MDMount Sinai Hospital, New York, New York (T.R.), Monica Mukherjee, MD, MPHJohns Hopkins University School of Medicine, Baltimore, Maryland (M.M.), and Asa Radix, MD, MPHCallen-Lorde Community Health Center, New York, New York (A.R.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L18-0563 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Getahun and colleagues (1) performed a retrospective analysis on 2842 transgender women and 2118 transgender men to determine the rates of acute cardiovascular events in these populations. Among their conclusions, the authors found that transgender women receiving estrogen have a higher rate of acute cardiovascular events than age-matched cisgender men or women. However, they did not account for known health disparities among transgender women that can contribute to such events; for example, transgender women have higher rates of HIV and serious psychological distress, both of which can contribute to worse cardiovascular outcomes (2–4). Furthermore, transgender women frequently ...References1. Getahun D, Nash R, Flanders WD, Baird TC, Becerra-Culqui TA, Cromwell L, et al. Cross-sex hormones and acute cardiovascular events in transgender persons: a cohort study. Ann Intern Med. 2018;169:205-13. [PMID: 29987313]. doi:10.7326/M17-2785 LinkGoogle Scholar2. James SE, Herman JL, Rankin S, Keisling M, Mottet L, et al. The Report of the 2015 U.S. Transgender Survey. Washington, DC: National Center for Transgender Equality; 2016. Google Scholar3. Triant VA, Lee H, Hadigan C, Grinspoon SK. Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease. J Clin Endocrinol Metab. 2007;92:2506-12. [PMID: 17456578] CrossrefMedlineGoogle Scholar4. Chiu M, Vigod S, Rahman F, Wilton AS, Lebenbaum M, Kurdyak P. Mortality risk associated with psychological distress and major depression: a population-based cohort study. J Affect Disord. 2018;234:117-23. [PMID: 29525352] doi:10.1016/j.jad.2018.02.075 CrossrefMedlineGoogle Scholar5. Witcomb GL, Bouman WP, Claes L, Brewin N, Crawford JR, Arcelus J. Levels of depression in transgender people and its predictors: results of a large matched control study with transgender people accessing clinical services. J Affect Disord. 2018;235:308-15. [PMID: 29665513] doi:10.1016/j.jad.2018.02.051 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Center for Transgender Medicine and Surgery Mount Sinai Health System, New York, New York (Z.G.)Boston University School of Medicine, Boston, Massachusetts (C.S.)Mount Sinai Hospital, New York, New York (T.R.)Johns Hopkins University School of Medicine, Baltimore, Maryland (M.M.)Callen-Lorde Community Health Center, New York, New York (A.R.)Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L18-0563. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCross-sex Hormones and Acute Cardiovascular Events in Transgender Persons Darios Getahun , Rebecca Nash , W. Dana Flanders , Tisha C. Baird , Tracy A. Becerra-Culqui , Lee Cromwell , Enid Hunkeler , Timothy L. Lash , Andrea Millman , Virginia P. Quinn , Brandi Robinson , Douglas Roblin , Michael J. Silverberg , Joshua Safer , Jennifer Slovis , Vin Tangpricha , and Michael Goodman Cross-Sex Hormones and Acute Cardiovascular Events in Transgender Persons Michael Goodman , Darios Getahun , Michael J. Silverberg , Joshua Safer , and Vin Tangpricha Metrics Cited byCardiovascular disease and feminizing gender-affirming hormone therapy: Implications for the provision of safe and lifesaving careDistribution of High-Sensitivity Cardiac Troponin and N-Terminal Pro–Brain Natriuretic Peptide in Healthy Transgender PeopleHomophobia, conversion therapy, and care models for trans youth: defending the gender-affirmative approach 15 January 2019Volume 170, Issue 2Page: 142-143KeywordsCardiovascular diseasesEstrogensHealth care providersHormonal therapyHormonesMedical risk factorsPopulation statisticsPreventive medicinePsychiatry and mental healthSuicide ePublished: 15 January 2019 Issue Published: 15 January 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...