tbuckley/cabot-search huggingface dataset:
The Avitaminoses: The Chemical, Clinical and Pathological Aspects of the Vitamin Deficiency Diseases
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
99mTc-HYNIC-TOC in the Evaluation of Recurrent Tumor-Induced Osteomalacia
Authors: Ximin Shi, Hongli Jing, Fang Li, Yupei Zhao, Zhenghua Wang, Li Huo
Journal: Clinical Nuclear Medicine (2019)

Tumor-induced osteomalacia (TIO) is rare paraneoplastic disorder generally caused by small benign neoplasm. Somatostatin receptor imaging has emerged as imaging of the choice in the localization of the causative tumors in new patients with clinical diagnosis of TIO. An accurate localization of the causative tumor using somatostatin receptor imaging followed by successful surgical removal offers cure of the disease. In small percentage of the patients, however, there can be recurrent disease after the surgery. In this retrospective investigation, we tried to assess whether somatostatin receptor imaging using Tc-HYNIC-TOC (Tc-hydrazinonicotinyl-Tyr3-octreotide) is also useful in patients with recurrent TIO after initial successful surgery.The images of Tc-HYNIC-TOC images and clinical charts of total 18 patients with suspected recurrent TIO were retrospectively reviewed. The image findings were compared with the clinical chart, which include clinical follow-up and subsequent imaging and surgery.Among all 18 patients, Tc-HYNIC-TOC imaging results were negative in 5 of them. Among these 5 patients with negative imaging study, the causes of recurrent symptoms and hypophosphatemia in 3 patients were eventually found unrelated to TIO. Tc-HYNIC-TOC successfully identified either recurrent causative tumors in the same location (n = 10) or different causative tumor in other locations (n = 3) in 13 patients, which rendered a sensitivity of 86.7% (13 of 15).The efficacy of Tc-HYNIC-TOC imaging in the evaluation of patients with potential recurrent TIO is compatible to that with new patients who never received surgical resection for the culprit tumors. It can play an important role in known TIO patients who were suspected to have recurrent disease.
A Feasibility Randomized Trial of Red Cell Transfusion Thresholds in Myelodysplasia
Authors: Simon Stanworth, Sally Killick, Zoe McQuilten, Marina Karakantza, Heather Smethurst, Laura Pankhurst, Renate L Hodge, Valerie Hopkins, Helen Thomas, Alison J Deary, Rena Buckstein, Jeannie Callum, Yulia Lin, David Bowen
Journal: Blood (2018)
Network analysis reveals causal key driver genes of severe asthma in children
Authors: Anh N. Do, Yoojin N. Chun, Jade T. Andrade, Galina T. Grishina, Alexander V. Grishin, Alfin T. Vicencio, Eric T. Schadt, Supinda Bunyavanich
Journal: Journal of Allergy and Clinical Immunology (2019)
Danazol Treatment for Thrombocytopenia in Lower-Risk Myelodysplastic Syndromes: A Pilot Real Life Experience
Authors: Marta Riva, Lara Crucitti, Emanuele Ravano, Michele Nichelatti, Gianluigi Reda, Cristina Fiamenghi, Roberto Cairoli, Alfredo Molteni
Journal: Blood (2018)
Abstract 21211: Serial OCT Evaluation of Stent Apposition and Longitudinal Deformation of Cobalt-Chromium versus Platinum-Chromium Everolimus Eluting Stents
Authors: Vikas Thondapu, Umair Hayat, Gishel New, Christopher Raffel, Darren Walters, Harry Lowe, George Proimos, Melanie Freeman, William Van Gaal, Anoop Koshy, Dominic Chow, Robert Whitbourn, Andrew MacIsaac, Peter Barlis
Journal: Circulation (2017)

Introduction: Despite advances in coronary stent design, restenosis and thrombosis remain rare but potentially serious complications that may be related to stent malapposition and longitudinal deformation. As such, the aim of this study was to evaluate stent apposition, tissue coverage and longitudinal deformation in two second-generation everolimus-eluting stents (EES) with serial optical coherence tomography (OCT). Methods: Sixty patients recruited from 5 interventional cardiology centers were randomized (1:1) to receive either the cobalt-chromium (CoCr) EES or platinum-chromium (PtCr) EES (n=30 in each group). Patients had OCT imaging after nominal and high-pressure post-dilation and at 6 months, with 12 month clinical follow up. Strut apposition and stent length were measured by OCT at each time point. The primary endpoint was the percentage of struts malapposed before and after optimal post-dilation. Secondary OCT endpoints were percent of struts apposed and covered at 6 months and percent change in stent length, classified as mild (&lt;5%), moderate (5-10%) or severe (&gt;10%). Results: All results are presented as CoCr-EES versus PtCr-EES. A total of 38,948 struts were analysed by OCT. After nominal dilation, the percent of malapposed struts was 12.4% versus 15.8% (p=0.34). After post-dilation the percentage malapposition was 9.5% versus 10% (p=0.81). At 6 months, the percentage of struts covered and apposed was 81.7% versus 81% (p=0.87). There was no significant difference between groups in the mean change in stent length (nominal: 6.38% versus 4.26%, p=0.24; post-dilation: 4.18% versus 4.97%, p=0.52; 6 months: 6.91% versus 8.61%, p=0.49). However, at 6 months the PtCr-EES manifested significantly more cases of severe change in stent length (&gt;10%) than the CoCr-EES (2 versus 8 cases, p=0.03) but were not associated with adverse clinical events during the study period. Conclusions: Both CoCr-EES and PtCr-EES stents demonstrate high rates of apposition and tissue coverage over 6 months with no significant differences in clinical outcomes. The PtCr-EES stent may be more susceptible to late stent deformation at 6 months but the true incidence, mechanisms, and clinical significance are as yet unclear.
A Novel Mass Spectrometry Method to Identify the Serum Monoclonal Light Chain Component and Infer Organ Involvement in Systemic Light Chain Amyloidosis
Authors: Faye Sharpley, Richa Manwani, Shameem Mahmood, Sajitha Sachchithanantham, Helen Lachmann, Julian Gillmore, Carol Whelan, Philip Hawkins, Ashutosh D. Wechalekar
Journal: Blood (2018)
New Chronic Constipation Medication
Authors: Rebecca Voelker
Journal: JAMA (2019)

The FDA has approved a once-daily oral treatment for adults with chronic idiopathic constipation. Prucalopride is a selective serotonin-4 (5HT4) receptor agonist that enhances colonic peristalsis to increase bowel motility. The drug has been approved for use in Europe since 2009.
Critical Care Management of Chimeric Antigen Receptor T Cell–related Toxicity. Be Aware and Prepared
Authors: Elie Azoulay, Alexander Shimabukuro-Vornhagen, Michael Darmon, Michael von Bergwelt-Baildon
Journal: American Journal of Respiratory and Critical Care Medicine (2019)

CAR (chimeric antigen receptor) T cells (CARTs) are genetically engineered T cells that express CARs, with impressive clinical activity in relapsed and refractory hematologic malignancies, primarily acute lymphoblastic leukemia and diffuse large B-cell lymphoma. The most frequent life-threatening adverse events after CART infusion are cytokine release syndrome and CAR-related encephalopathy syndrome, which can occur within hours or days after administration. IL-6 released by macrophages and monocytes plays a major role in the pathogenesis of cytokine release syndrome and CAR-related encephalopathy syndrome, and IL-6 blockade and steroids contribute to fast resolution of symptoms. Critical care management plays an important role in patients receiving CARTs, as up to half of patients might need an admission to the ICU and lifesaving interventions. As new treatment indications and CART constructs enter the clinic, the number of patients requiring ICU admission will rapidly increase, with profound consequences for the use of ICU resources, training requirements, clinical expertise, multidisciplinary collaboration, and hospital organization. Research is also needed to validate at large scale biomarkers that allow doctors to risk-stratify patients for both their risk to develop severe toxicity and their likelihood to respond to therapy.
Association between sarcopenia and gastric carcinogenesis: A health check-up cohort study.
Authors: Young Min Kim, Jie-Hyun Kim, Su Jung Baik, Da Hyun Jung, Jae Jun Park, Young Hoon Youn, Hyojin Park
Journal: Journal of Clinical Oncology (2019)

46 Background: Insulin resistance which is a mechanism of metabolic syndrome has been known to promote carcinogenesis of various malignancies. In addition, metabolic syndrome is associated with sarcopenia. Thus, the aim was to investigate the association between sarcopenia and gastric carcinogenesis including precancerous conditions: atrophic gastritis (AG), intestinal metaplasia (IM), and gastric adenoma. Methods: The study subjects were an adult population who underwent gastroduodenoscopy at Gangnam Severance Check-up Center. AG and IM were evaluated by endoscopic findings. Sarcopenia based on muscle mass was defined as appendicular skeletal muscle (ASM) as a percentage of body weight that was less than 1 standard deviation below the sex-specific mean for healthy adults aged 20 to 39 years (cutoff point: 29.3% in male and 26.7% in female). Obesity was defined as body mass index (BMI) ≥ 25 kg/m2 according to the Asia-Pacific criteria. Sarcopenic obesity was a condition of combined sarcopenia and obesity. The association between sarcopenia and gastric lesions was evaluated. Results: 8,356 patients were enrolled this study. Among them, 12 (0.14%) and 3,552 (42.5%) patients were diagnosed as gastric cancer and precancerous conditions, respectively. 5 (41.7%) of 12 gastric cancer patients and 594 (16.9%) of 3.552 patients with gastric precancerous conditions were diagnosed with sarcopenia. Both diabetes mellitus (DM) (OR = 5.152, P = 0.005) and sarcopenic obesity (OR = 4.139, P = 0.016) were independent predictive factors for gastric cancer. And smoking, alcohol, DM, hypertension, dyslipidemia, Helicobacter pylori, and sarcopenia were significantly associated with gastric precancerous conditions. Conclusions: Sarcopenia and sarcopenic obesity were significantly associated with gastric carcinogenesis. Thus, sarcopenia may be one of the risk factors for gastric carcinogenesis.
Genetic mechanisms of primary chemotherapy resistance in pediatric acute myeloid leukemia
Authors: Nicole A. McNeer, John Philip, Heather Geiger, Rhonda E. Ries, Vincent-Philippe Lavallée, Michael Walsh, Minita Shah, Kanika Arora, Anne-Katrin Emde, Nicolas Robine, Todd A. Alonzo, E. Anders Kolb, Alan S. Gamis, Malcolm Smith, Daniela Se Gerhard, Jaime Guidry-Auvil, Soheil Meshinchi, Alex Kentsis
Journal: Leukemia (2019)
Food Protein Induced Enterocolitis Syndrome (FPIES): Data from a Tertiary Care Center in Developing Country
Authors: Athipat Athipongarporn, Jaichat Mekaroonkamol, Thansinee Saetae, Jarungchit Ngamphaiboon, Narissara Suratannon, Pantipa Chatchatee
Journal: Journal of Allergy and Clinical Immunology (2019)
Acute care assessment of older adults living with frailty
Authors: Terence J Quinn, Simon P Mooijaart, Katie Gallacher, Jennifer K Burton
Journal: BMJ (2019)

What you need to know• Older people living with frailty are frequent users of acute care services • The approach to assessment of frail older adults is different to that of a younger patient• Assess older adults presenting to acute care for frailty syndromes (falls, immobility, incontinence, confusion), and get collateral history from caregivers• Establish the priorities and goals for the individual to ensure that investigations and treatment accord with what matters to them and their families
Abstract 14780: Analytical Identification of Stable Hemodynamic Conditions in Patients With Transposition of the Great Arteries
Authors: Ryo Inuzuka, Hideaki Senzaki
Journal: Circulation (2016)

Introduction: Newborns with transposition of the great arteries (TGA) have systemic and pulmonary circulation in parallel; thus, mixing of both circulations is essential to maintain appropriate oxygen saturation level. However, shunt flow through a patent ductus arteriosus (PDA), ventricular septal defect (VSD), and atrial septal defect (ASD) may result in hemodynamic instability against a decrease in pulmonary arterial resistance. This tradeoff between oxygen saturation and hemodynamic stability should be fully understood for better management of patients with this unique circulation, but has never been elucidated. Methods: We developed a lumped parameter model for TGA circulation based on the 3-element Windkessel model coupled with the time-varying elastance model of the ventricles. We examined the impacts of the shunt sizes and locations on oxygen saturation and cardiac index (CI) by combining various sizes of ASD, VSD and PDA. Contribution of each shunt to the mixing between systemic and pulmonary cir...
Abstract 19: Epidemiologic Surveillance of Kawasaki Disease in Manitoba and Northwestern Ontario 2000-2010
Authors: Dionysios Pepelassis, Maria E Lautatzis, Daryl Schantz, Jeff Hyman, Reeni Soni, Ilan Buffo
Journal: Circulation (2015)

Objective: The purpose of this study is to determine the incidence of persistent coronary artery sequelae due to KD between the First Nation/Metis (FN/M) and non First Nation children (n-FN) in the province of Manitoba and Northwestern Ontario, Canada. Methods: This is a 10-year (2000-2010) retrospective chart review study of all patients &lt; 18 years of age identified with KD and persistent coronary artery aneurysms. The data was obtained from the Children’s Hospital of Winnipeg medical records and the Electronic Echocardiography data based at the Variety Heart Centre. Results: A total of 103 children and adolescents with KD and with at least 3 echocardiography studies were enrolled. Complete or incomplete presentation of KD was determined according to the fulfillment for the disease classic criteria on diagnosis. Age at diagnosis ranged between 2 months to 4 years (median 0.5 years) with 2 patients diagnosed during their early infancy (age&lt; 90 days). The median follow up period was 4 years (1.3 to 6.3 years). Persistent coronary artery aneurysms were detected in 10 children (M/F ratio 3:1). Nine (9) of the studied subjects account for the FN/M children group and the remaining 1 is of Asian origin. We observed no n-FN children with permanent cardiac sequelae secondary to KD. Conclusion: There is a significantly higher occurrence of permanent coronary artery lesions due to KD among the FN/M children in the province of Manitoba and Northwestern Ontario. However, this study does not imply direct association of any risk factor, which might be related with our findings. Socio-environmental or even genetic factors might contribute to these findings. Nevertheless, these speculations are beyond the scope of this study. We suggest that a strategy of early, diagnosis and treatment of KD based on the latest AHA guidelines, when we deal with patients of these ethnic/racial groups, should be implemented.
Effect Of Air Cleaners (Intense Pure Air® XL) On Early And Late Asthmatic Response In Asthmatic Subjects Sensitized To Cat In ALYATEC's Environmental Exposure Chamber (EEC)
Authors: Frederic J. De Blay De Gaix, Alina Gherasim, Nicole Beck, Audrey Jacob, Florian Schoettel, Nathalie Domis
Journal: Journal of Allergy and Clinical Immunology (2019)
Modulation of temozolomide dose differentially affects T-cell response to immune checkpoint inhibition
Authors: Aida Karachi, Changlin Yang, Farhad Dastmalchi, Elias J Sayour, Jianping Huang, Hassan Azari, Yu Long, Catherine Flores, Duane A Mitchell, Maryam Rahman
Journal: Neuro-Oncology (2019)

The changes induced in host immunity and the tumor microenvironment by chemotherapy have been shown to impact immunotherapy response in both a positive and a negative fashion. Temozolomide is the most common chemotherapy used to treat glioblastoma (GBM) and has been shown to have variable effects on immune response to immunotherapy. Therefore, we aimed to determine the immune modulatory effects of temozolomide that would impact response to immune checkpoint inhibition in the treatment of experimental GBM.Immune function and antitumor efficacy of immune checkpoint inhibition were tested after treatment with metronomic dose (MD) temozolomide (25 mg/kg × 10 days) or standard dose (SD) temozolomide (50 mg/kg × 5 days) in the GL261 and KR158 murine glioma models.SD temozolomide treatment resulted in an upregulation of markers of T-cell exhaustion such as LAG-3 and TIM-3 in lymphocytes which was not seen with MD temozolomide. When temozolomide treatment was combined with programmed cell death 1 (PD-1) antibody therapy, the MD temozolomide/PD-1 antibody group demonstrated a decrease in exhaustion markers in tumor infiltrating lymphocytes that was not observed in the SD temozolomide/PD-1 antibody group. Also, the survival advantage of PD-1 antibody therapy in a murine syngeneic intracranial glioma model was abrogated by adding SD temozolomide to treatment. However, when MD temozolomide was added to PD-1 inhibition, it preserved the survival benefit that was seen by PD-1 antibody therapy alone.The peripheral and intratumoral immune microenvironments are distinctively affected by dose modulation of temozolomide.
Antitumor activity of margetuximab (M) plus pembrolizumab (P) in patients (pts) with advanced HER2+ (IHC3+) gastric carcinoma (GC).
Authors: Daniel V.T. Catenacci, Kian Huat Lim, Hope Elizabeth Uronis, Yoon-Koo Kang, Matthew C.H. Ng, Philip Jordan Gold, Peter C. Enzinger, Keun Wook Lee, Jill Lacy, Se Hoon Park, Jennifer Yen, Justin Odegaard, Aleksandra Franovic, Jan E. Baughman, Aisha Wynter-Horton, Francine Chen, Paul A. Moore, Tony Wu, Jan Kenneth Davidson-Moncada, Yung-Jue Bang
Journal: Journal of Clinical Oncology (2019)

65 Background: Trastuzumab (T) + chemo is standard first-line therapy (tx) for HER2+ gastroesophageal adenocarcinoma (GEA) pts, though progression ensues in 6-8 months. The approved second-line tx is ramucirumab +/- paclitaxel (R+PAC). Pts with GC are less responsive to R+PAC than gastroesophageal junction (GEJ) pts, in particular HER2+ GC, and no anti-HER2 agents are approved in post-T setting. We report results of combination M+P in HER2+ GC pts and describe a biological rationale for this population. M is an anti-HER2 mAb Fc optimized for enhanced binding to activating FcgRIIIa (CD16A) and decreased binding to inhibitory FcgRIIb (CD32B). M demonstrated an enhanced Fc-dependent MoA, including enhanced ADCC. Methods: HER2+, PD-L1-unselected, second-line GEA pts post T progression received M (15 mg/kg) + P (200 mg) Q3wk. Safety, objective response rate (ORR), median overall &amp; progression-free survival (mOS, mPFS), disease control rate (DCR), circulating tumor DNA, &amp; tumor PD-L1 expression were assessed. Results: To date, 66 GEA pts were dosed; 35 (53%) GC and 31 (47%) GEJ. Overall, 12/66 (18.2%) had tx-related adverse events ≥ grade 3; 5 had drug-related SAEs: dehydration, diabetic ketoacidosis, hypotension and pneumonitis, each a single event, and 2 events of autoimmune hepatitis. Eligibility was based on archival HER2 expression; an exploratory endpoint measured retention of HER2 expression post-T by ERBB2 ctDNA. HER2 expression was lost in 23/56 (41.1%) of pts tested post T. HER2 retention was higher in pts with GC versus GEJ (65.8% vs. 44.8%) and in GEA pts with IHC 3+ vs 2+ archival tumors (61.7% vs 47.4%, respectively). Furthermore, GC had higher PD-L1 expression than GEJ, 53.3 vs. 33.3%, respectively. This coincided with more responses in IHC3+ GC pts, ORR 12/29 (41.4%; 95% CI 23.5-61.1), DCR 21/29 (72.4%; 95% CI 52.8-87.3), mPFS 5.5 months (95% CI 2.3-7.6), mOS not reached, with lower bound of 9.1 months for 95% CI. Enrollment of an additional 25 pts enriched for IHC3+ GC is ongoing. Conclusions: Results suggest that M+P, a chemo-free regimen, demonstrates acceptable tolerability and has encouraging preliminary activity in second-line HER2+ GEA, specifically in GC pts who retain ERBB2 amp prior to second-line tx. Clinical trial information: NCT02689284.
Shy and/or fearful temperament not associated with IgE mediated food allergy in early childhood
Authors: Renata Ndahayo, Victoria Martin, Hannah L. Seay, Yamini V. Virkud, Qian Yuan, Wayne G. Shreffler, Nancy S. Rotter, Dina Hirshfield- Becker
Journal: Journal of Allergy and Clinical Immunology (2019)
Relationship of serological reactivity to cytoplasmic extracts from spores of Ganoderma applanatum and commercial extracts of indoor, mitosporic fungi, and farm animal allergens among Puerto Rican subjects
Authors: Felix E. Rivera-Mariani, Hayat H. Srour, Joshua K. Baguley, Shandra V. Bellinger, Ariel J. Stateman, Benjamin Bolanos
Journal: Journal of Allergy and Clinical Immunology (2019)
Abstract 15421: Effect of Weight Loss Intervention Program on Cardiac Function, Endothelium Progenitor Cells and Microparticles in Mildly Obese Asians
Authors: Poay Sian S Lee, Fathimath Naseer, Su Lin Lim, Eric Y Khoo, Tiong Cheng Yeo, Arthur Mark Richards, Kian Keong Poh
Journal: Circulation (2016)

Introduction: The effect of weight lost through lifestyle intervention on cardiac function are not well elucidated, especially in Asians where body mass index (BMI) cut-offs are lower than in the W...
AK002, a Novel Humanized Monoclonal Antibody to Siglec-8, Inhibits Mast Cell Activity and Depletes Eosinophils in Ex Vivo Bone Marrow Tissue from Patients with Systemic Mastocytosis
Authors: Bradford A Youngblood, Emily C Brock, John Leung, Alan T Chang, Christopher Bebbington, Nenad Tomasevic
Journal: Blood (2018)
Abstract 17831: Quantifying Infective Endocarditis Risk in Patients With Predisposing Heart Conditions: A Large Population-Based Cohort Study
Authors: Mark J Dayer, Simon Jones, Bernard Prendergast, Larry M Baddour, John Chambers, Peter B Lockhart, Martin H Thornhill
Journal: Circulation (2016)

Introduction: Identifying individuals at risk of infective endocarditis (IE) is important for targeting prevention and raising the index of suspicion for early diagnosis. There is, however, scant c...