SAT0400 Infectious spondylodiscitis: 7-year analysis of clinical and prognostic variables in a tertiary hospital
Authors: J. Fragio, R. Gonzalez Mazario, E. Labrador Sanchez, E. Grau Garcia, K.R. Arevalo Ruales, M. de la Rubia Navarro, C. Alcañiz Escandell, L. Gonzalez Puig, J. Ivorra Cortes, I. Martinez Cordellat, I. Canovas Olmos, C.V. Inmaculada, C. Najera Herranz, C. Feced Olmos, R. Negueroles Albuixech, J.E. Oller Rodriguez, F.M. Ortiz Sanjuan, V. Fornes Ferrer, M. Tasias Pitarch, E. Calabuig Muñoz, M. Salavert Lleti, J.A. Roman Ivorra
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Spondylodiscitis is an infectious disease of the vertebral body and intervertebral space, the early diagnosis and treatment are essential to give the patient the best chance of a good outcome, but these are often delayed because it tends to present nonspecific manifestations. <h3>Objectives</h3> To analyse cases of Spondylodiscitis and identify poor prognosis variables. <h3>Methods</h3> A retrospective observational study, included all adult patients with confirmed infectious spondylodiscitis between <sup>January 2010</sup> and December 2017. Demographic features, concurrent disease, clinical history, laboratory findings, microbiological diagnosis, radiological data and clinical outcome were compiled from the clinical history management software. Statistical analysis was performed with the software R (version 3.3.2). <h3>Results</h3> We included 87 patients with a mean age of 62.05 (16.94) years old. Males predominated (69%). Almost 31% patients presented of a level of immunosuppression (immunosuppression treatment, cirrhosis, HIV infection, solid organ transplantation). The average time with axial pain was 74 (87.65) days. Mean length of hospital stay was 34.24 (34.3) days and readmission rate was 34.9%. Most of patients showed high CRP levels at their admission, with an average value of 88.92 (84.58) mg/L, it was not correlated with worse prognosis. Underlying endocarditis proportion was 11.5%. Blood cultures were positive in 29 patients (33,3%), it was correlated with hospital stay (p=0,03). 51 patients had puntion-aspiration and intervertebral biopsy with microbiologic findings diagnosis in 30 patients (58.8%): 42.5% patients had an identifiable gram +bacteria (37,8% <i>Streptococcus</i> genere), 13.7% a Gram- bacteria, <i>Mycobacterium tuberculosis</i> in 8% and fungi infection (all <i>Candida spp</i>.) in 3.4%. 38% of patients showed vertebral destruction on MRI; 17.4% cord compression and developed neurological complications (8 of them paraparesis). 18.4% of patients required further surgical procedures. Furthermore, vertebral destruction was statistically correlated with epidural abscess (p=0,006). Almost 6% of patients died in the following year after diagnostic. <h3>Conclusions</h3> Delay in diagnosis is an important issue in Spondylodiscitis patients. Higher complications rates are mainly in relation to greater vertebral destruction. Underlying infectious endocarditis was described in a small proportion of patients in contrast to other studies. Presence of epidural abscess was also correlated with vertebral destruction, for this reason, patients with this finding should be more carefully follow-up. <h3>Disclosure of Interest</h3> None declared