tbuckley/cabot-search huggingface dataset:
Prognostic value of minimal residual disease and polyclonal plasma cells in myeloma patients achieving a complete response to therapy
Authors: Marcella A. Tschautscher, Dragan Jevremovic, Vincent Rajkumar, Angela Dispenzieri, Martha Q. Lacy, Morie A. Gertz, Francis K. Buadi, David Dingli, Yi L. Hwa, Amie L. Fonder, Miriam A. Hobbs, Suzanne R. Hayman, Steven R. Zeldenrust, John A. Lust, Stephen J. Russell, Nelson Leung, Prashant Kapoor, Ronald S. Go, Yi Lin, Wilson I. Gonsalves, Taxiarchis Kourelis, Rahma Warsame, Robert A. Kyle, Shaji K. Kumar
Journal: American Journal of Hematology (2019)

Abstract Achievement of a complete response has been associated with improved outcomes in patients with multiple myeloma. Recently, increasing application of minimal residual disease (MRD) assessment has shown that MRD negativity is a powerful prognostic factor for survival outcomes. We wanted to examine the impact of the polyclonal plasma cell (pPC) compartment among patients in complete response (CR) but are MRD positive. This is a retrospective cohort study where 460 myeloma patients were identified who met criteria for CR and had multicolor flow cytometry performed on the bone marrow (BM). Monoclonal and pPCs were estimated during MRD testing. Final outcomes including overall survival (OS) and time to next treatment (TTNT) were compared among the groups. The median OS for the entire cohort was not reached (95% CI; 63 mos, NR) and the median TTNT was 31 months (95% CI; 27,36). Among the MRD neg group, median TTNT was 37.6 months vs 23 months for MRD pos patients ( P &lt; .001); the median OS was not reached for either group, but there was a trend toward better survival for MRD neg patients. Among the MRD pos group, median percentage of pPCs was 65% (2.5–98.5), and those with &gt;95% pPCs had a significantly better TTNT (NR vs 23 months; P = .02) and a trend toward better OS. We conclude that achievement of MRD negativity predicts for better response durability and trend toward improved OS and an increased proportion of pPC predicts for better outcomes within those who have residual tumor cells highlighting the importance of marrow normalization.
Gastric Bleeding Induced by a Solitary Juvenile Polyp
Authors: Yutaka Okagawa, Tetsuya Sumiyoshi, Hitoshi Kondo
Journal: Clinical Gastroenterology and Hepatology (2019)

A 22-year-old woman was admitted urgently into our hospital because of melena. The result of the hematologic blood test showed severe anemia (hemoglobin, 5.5 mg/dL). Emergency esophagogastroduodenoscopy revealed a giant pedunculated polyp in the greater curvature of the middle gastric body (Figure A). The head of the polyp was lobular appearance (Figure B). Because bleeding from the polyp was observed, endoscopic hemostasis by resection of the polyp was achieved with hot snare polypectomy. The polyp measured 50 × 35 × 15 mm macroscopically. Histopathologic findings revealed hyperplasia of the glandular epithelium without malignant findings (Figure C), and the glands also increased with cystic dilatation (Figure D). The polyp was finally diagnosed as a juvenile polyp because pathologic findings of other types of hamartomatous polyp, such as Peutz-Jeghers-type polyp, were not identified. The patient had no familial history of juvenile polyposis syndrome, and total colonoscopy and capsule endoscopy revealed no polyps in the colon and small intestine. Most gastric juvenile polyps are associated with juvenile polyposis syndrome, and there are few reports of a solitary juvenile polyp of the stomach. This is a rare case of a solitary gastric juvenile polyp where endoscopic polypectomy was useful for management of gastric bleeding.
Cleavage of anti-PF4/heparin IgG by a bacterial protease and potential benefit in heparin-induced thrombocytopenia
Authors: Claire Kizlik-Masson, Quentin Deveuve, Yuhang Zhou, Caroline Vayne, Gilles Thibault, Steven E. McKenzie, Claire Pouplard, Stéphane Loyau, Yves Gruel, Jérôme Rollin
Journal: Blood (2019)
Rebound Thrombocytosis after Induction Chemotherapy is a Strong Biomarker for Favorable Outcome in AML Patients
Authors: Bianca R. Schnell, Katja Seipel, Ulrike Bacher, Barbara Jeker, Beatrice U. Mueller, Yara Banz, Urban Novak, Thomas Pabst
Journal: HemaSphere (2019)

Whereas the molecular events underlying acute myeloid leukemia (AML) are increasingly identified, dynamics of hematologic recovery following induction chemotherapy remain mysterious. Platelet recovery may vary between incomplete and excess recovery among patients achieving remission. We analyzed platelet recovery after the first induction cycle in 291 consecutive AML patients. We defined excess platelet rebound (EPR) as platelet increase above 500 G/L. We observed EPR in 120 (41.2%) patients. EPR+ patients had lower platelets at diagnosis, higher marrow infiltration, more frequently NPM1 mutations, and were associated with ELN favorable risk. Absence of EPR correlated with complex karyotypes, ELN intermediate-I and adverse risk, and therapy-related AML. Overall survival was better in EPR+ patients than EPR- (median 125 vs 41 months; p = 0.04), as was disease-free survival. By multivariate analysis, EPR+ was an independent parameter associated with favorable survival. Plasma thrombopoietin (TPO) levels at diagnosis indicated EPR+ (p < 0.0001), while GATA-1, GATA-2, and MPL mRNA expression did not differ between EPR+ and EPR- patients. Finally, transcription factors blocking early megakaryopoiesis were upregulated in EPR- patients, while NFE2 involved in late megakaryocyte differentiation was increased in EPR+ patients. Our work identifies mechanisms involved in platelet recovery after induction chemotherapy.
Red blood cells modulate structure and dynamics of venous clot formation in sickle cell disease
Authors: Camille Faes, Anton Ilich, Amandine Sotiaux, Erica M. Sparkenbaugh, Michael W. Henderson, Laura Buczek, Joan D. Beckman, Patrick Ellsworth, Denis F. Noubouossie, Lantarima Bhoopat, Mark Piegore, Céline Renoux, Wolfgang Bergmeier, Yara Park, Kenneth I. Ataga, Brian Cooley, Alisa S. Wolberg, Nigel S. Key, Rafal Pawlinski
Journal: Blood (2019)
Effect of Radiotherapy After Breast-Conserving Surgery Depending on the Presence of Tumor-Infiltrating Lymphocytes: A Long-Term Follow-Up of the SweBCG91RT Randomized Trial
Authors: Anikó Kovács, Axel Stenmark Tullberg, Elisabeth Werner Rönnerman, Erik Holmberg, Linda Hartman, Martin Sjöström, Dan Lundstedt, Per Malmström, Mårten Fernö, Per Karlsson
Journal: Journal of Clinical Oncology (2019)

PURPOSE The effects of radiotherapy (RT) on the basis of the presence of stromal tumor infiltrating lymphocytes (TILs) have not been studied. The purpose of this study was to analyze the association of TILs with the effect of postoperative RT on ipsilateral breast tumor recurrence (IBTR) in a large randomized trial. METHODS In the SweBCT91RT (Swedish Breast Cancer Group 91 Radiotherapy) trial, 1,178 patients with breast cancer stage I and II were randomly assigned to breast-conserving surgery plus postoperative RT or breast-conserving surgery only and followed for a median of 15.2 years. Tumor blocks were retrieved from 1,003 patients. Stromal TILs were assessed on whole-section hematoxylin-eosin–stained slides using a dichotomized cutoff of 10%. Subtypes were scored using immunohistochemistry on tissue microarray. In total, 936 patients were evaluated. RESULTS Altogether, 670 (71%) of patients had TILs less than 10%. In a multivariable regression analysis with IBTR as dependent variable and RT, TILs, subtype, age, and grade as independent variables, RT (hazard ratio [HR], 0.42; 95% CI, 0.29 to 0.61; P &lt; .001), high TILs (HR, 0.61; 95% CI, 0.39 to 0.96, P = .033) grade (3 v 1; HR, 2.17; 95% CI, 1.08 to 4.34; P = .029), and age (≥ 50 v &lt; 50 years; HR, 0.55; 95% CI, 0.38 to 0.80; P = .002) were predictive of IBTR. RT was significantly beneficial in the low TILs group (HR, 0.37; 95% CI, 0.24 to 0.58; P &lt; .001) but not in the high TILs group (HR, 0.58; 95% CI, 0.28 to 1.19; P = .138). The test for interaction between RT and TILs was not statistically significant ( P = .317). CONCLUSION This study shows that high values of TILs in the primary tumor independently seem to reduce the risk for an IBTR. Our findings further suggest that patients with breast cancer with low TILs may derive a larger benefit from RT regarding the risk of IBTR.
Ensuring Equity and Justice in the Care and Outcomes of Patients With Cancer
Authors: Blase N. Polite, Abbe R. Gluck, Otis W. Brawley
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Loss of Super-Enhancer-Regulated circRNA Nfix Induces Cardiac Regeneration After Myocardial Infarction in Adult Mice
Authors: Senlin Huang, Xinzhong Li, Hao Zheng, Xiaoyun Si, Bing Li, Guoquan Wei, Chuling Li, Yijin Chen, Yanmei Chen, Wangjun Liao, Yulin Liao, Jianping Bin
Journal: Circulation (2019)

circRNAs (circular RNAs) are emerging as powerful regulators of cardiac development and disease, but their roles in cardiac regeneration are still unknown. This study used superenhancers to distinguish key circRNAs in the regulation of cardiac regeneration and explored the mechanisms underlying circRNA functions.We used integrated bioinformatics analysis of RNA sequencing data and superenhancer catalogs to identify superenhancer-associated circRNAs. Quantitative polymerase chain reactions and in situ hybridization were performed to determine the circRNA expression patterns in hearts. Gain- and loss-of-function assays were conducted to detect the role of circRNAs in cardiomyocyte proliferation and cardiac repair after myocardial infarction. Chromatin immunoprecipitation (ChIP) and electrophoretic mobility shift assays were used to determine the binding of Meis1 (Meis homeobox 1) on circNfix-associated superenhancers. RNA pulldown and luciferase reporter assays were used to study circRNA interactions with proteins and miRNAs (micro RNAs).We identified a circRNA, Nfix circRNA (circNfix), that was regulated by a superenhancer and overexpressed in the adult heart in humans, rats, and mice. The transcription factor Meis1 bound to the superenhancer at the circNfix locus, and increased its expression. In vitro and in vivo, cardiomyocyte proliferation was increased by knockdown of circNfix, whereas it was inhibited by circNfix overexpression. Moreover, circNfix downregulation promoted cardiomyocyte proliferation and angiogenesis and inhibited cardiomyocyte apoptosis after myocardial infarction, attenuating cardiac dysfunction and improving the prognosis. Mechanistically, circNfix reinforced the interaction of Ybx1 (Y-box binding protein 1) with Nedd4l (an E3 ubiquitin ligase), and induced Ybx1 degradation through ubiquitination, repressing cyclin A2 and cyclin B1 expression. In addition, circNfix acted as a sponge for miR-214 to promote Gsk3β (glycogen synthase kinase 3 β) expression and repress β-catenin activity.Loss of superenhancer-regulated circNfix promotes cardiac regenerative repair and functional recovery after myocardial infarction by suppressing Ybx1 ubiquitin-dependent degradation and increasing miR-214 activity and thus may be a promising strategy for improving the prognosis after MI.
Epidemiologic Trends in Malaria Incidence Among Travelers Returning to Metropolitan France, 1996-2016
Authors: Eric Kendjo, Sandrine Houzé, Oussama Mouri, Aida Taieb, Frédérick Gay, Stéphane Jauréguiberry, Ilhame Tantaoui, Papa A. Ndour, Pierre Buffet, Martine Piarroux, Marc Thellier, Renaud Piarroux
Journal: JAMA Network Open (2019)

<h3>Importance</h3> Despite annually adapted recommendations to prevent malaria in travelers to endemic areas, France is still the industrialized country reporting the highest number of imported cases of malaria. Better understanding of the epidemiologic context and evolution during the past 2 decades may help to define a better preventive strategy. <h3>Objective</h3> To study epidemiologic trends of imported cases of malaria in travelers in geographic territories of France on the European continent (metropolitan France) from 1996 through 2016 to potentially explain the persistence of high imported malaria incidence despite national preventive measures. <h3>Design, Setting, and Participants</h3> In a cross-sectional study, between January 1 and May 31, 2018, data were extracted from the French National Reference Center of Malaria Surveillance. Trends in patients with imported malaria in association with age, sex, ethnicity, purpose of travel, malaria species, severity of illness, case mortality rate, and endemic countries visited were analyzed in 43 333 malaria cases among civilian travelers living in metropolitan France. <h3>Main Outcomes and Measures</h3> Evolution of the main epidemiologic characteristics of patients with imported malaria. <h3>Results</h3> Among the 43 333 patients with imported malaria in civilian travelers included in the study, 24 949 were male (62.4%), and 8549 were younger than 18 years (19.9%). A total of 28 658 malaria cases (71.5%) were among African individuals, and 10 618 cases (26.5%) among European individuals. From 1996 through 2016, the number of confirmed malaria cases peaked at 3400 cases in 2000, then declined to 1824 cases in 2005 and stabilized thereafter to approximately 1720 malaria cases per year. A total of 37 065 cases (85.5%) were due to<i>Plasmodium falciparum</i>. The proportion of malaria cases among African individuals rose from 53.5% in 1996 to 83.4% in 2016, and the most frequent motivation for traveling was visiting friends and relatives (25 329 [77.1%];<i>P</i> &lt; .001). Despite an increase in the proportion of severe cases, which rose from 131 cases (8.9%) in 1996 to 279 cases (16.7%) in 2016 (<i>P</i> &lt; .001), mortality remained stable, being approximately 0.4% during the study period. <h3>Conclusions and Relevance</h3> Beyond the apparent stability of the number of imported malaria cases in France, significant changes appear to have occurred among the population who developed malaria infection following travel in endemic areas. These changes may imply that adaptation of the preventive strategy is needed to reduce the burden of the disease among travelers.
CGRP induction in cystic fibrosis airways alters the submucosal gland progenitor cell niche in mice
Authors: Weiliang Xie, John T. Fisher, Thomas J. Lynch, Meihui Luo, Turan I.A. Evans, Traci L. Neff, Weihong Zhou, Yulong Zhang, Yi Ou, Nigel W. Bunnett, Andrew F. Russo, Michael J. Goodheart, Kalpaj R. Parekh, Xiaoming Liu, John F. Engelhardt
Journal: Journal of Clinical Investigation (2015)

At the request of the corresponding author, the JCI is retracting the paper "FOXO3 programs tumor-associated DCs to become tolerogenic in human and murine prostate cancer" based on findings of data falsification and fabrication regarding Figures 1D and8A, likely data falsification regarding Figure 4A, likely falsification or fabrication regarding Figure 4B, and erroneous sample attribution in Table 1.
Treatment of complex airway stenoses using patient-specific 3D-engineered stents: a proof-of-concept study
Authors: Nicolas Guibert, Alain Didier, Benjamin Moreno, Benoit Lepage, Pierre Leyx, Gavin Plat, Laurent Mhanna, Marlene Murris, Julien Mazières, Christophe Hermant
Journal: Thorax (2019)

Anatomically complex airway stenosis (ACAS) represents a challenging situation in which commercially available stents often result in migration or granulation tissue reaction due to poor congruence. This proof-of-concept clinical trial investigated the feasibility and safety of computer-assisted designed (CAD) and manufactured personalised three-dimensional (3D) stents in patients with ACAS from various origins. After CAD of a virtual stent from a CT scan, a mould is manufactured using a 3D computer numerical control machine, from which a medical-grade silicone stent is made. Complication rate, dyspnoea, quality of life and respiratory function were followed after implantation. The congruence of the stent was assessed peroperatively and at 1 week postimplantation (CT scan). The stent could be implanted in all 10 patients. The 3-month complication rate was 40%, including one benign mucus plugging, one stent removal due to intense cough and two stent migrations. 9 of 10 stents showed great congruence within the airways, and 8 of 10 induced significant improvement in dyspnoea, quality of life and respiratory function. These promising outcomes in highly complex situations support further investigation on the subject, including technological improvements.​ Trial registration number NCT02889029 .
Defective Fibrillar Collagen Organization by Fibroblasts Contributes to Airway Remodeling in Asthma
Authors: Leila B. Mostaço-Guidolin, Emmanuel T. Osei, Jari Ullah, Soheil Hajimohammadi, May Fouadi, Xian Li, Vicky Li, Furquan Shaheen, Chen Xi Yang, Fanny Chu, Darren J. Cole, Corry-Anke Brandsma, Irene H. Heijink, Geoffrey N. Maksym, David Walker, Tillie-Louise Hackett
Journal: American Journal of Respiratory and Critical Care Medicine (2019)

Histologic stains have been used as the gold standard to visualize extracellular matrix (ECM) changes associated with airway remodeling in asthma, yet they provide no information on the biochemical and structural characteristics of the ECM, which are vital to understanding alterations in tissue function.
<sup>177</sup>Lu-Dotatate for Midgut Neuroendocrine Tumors
Authors: Nuriye Y Ozdemir, Suheyla A Arslan, Mehmet A Sendur
Journal: New England Journal of Medicine (2017)

_To the Editor:_  
Although the results of the multicenter, randomized, controlled Neuroendocrine Tumors Therapy (NETTER-1) trial reported by Strosberg et al. (Jan. 12 issue) validate the experience gained over the past decade by many institutions, we think that they overstate the toxic effects of lutetium-177 (177Lu)–Dotatate and potentially underestimate its efficacy relative to other potential therapies for these tumors. [...]
Reported Cases of Medical Malpractice in Direct-to-Consumer Telemedicine
Authors: Alexander L. Fogel, Joseph C. Kvedar
Journal: JAMA (2019)

In response to physicians' concerns about exposure to malpractice risk in direct-to-consumer (DTC) telemedicine, this study reviews the LexisNexis legal case database for reported cases of medical malpractice related to DTC telemedicine services or their health care professionals.
Impact of a 1-day versus 3-day low-residue diet on bowel cleansing quality before colonoscopy: a randomized controlled trial
Authors: Antonio Z. Gimeno-García, Raquel de la Barreda Heuser, Cristina Reygosa, Alberto Hernandez, Isabel Mascareño, David Nicolás-Pérez, Alejandro Jiménez, Antonio J. Lara, Onofre Alarcon-Fernández, Manuel Hernandez-Guerra, Rafael Romero, Inmaculada Alonso, Yanira González, Zaida Adrian, Goretti Hernandez, Domingo Hernandez, Rosa Delgado, Enrique Quintero
Journal: Endoscopy (2019)

Abstract Background The aim of this study was to assess whether a 3-day low-residue diet (LRD) improved bowel cleansing quality compared with a 1-day LRD regimen. Methods Consecutive patients scheduled for outpatient colonoscopy were randomized to the 1-day LRD or 3-day LRD groups. All patients received a 2-L split-dose of polyethylene glycol plus ascorbic acid. The primary outcome was bowel cleansing quality as evaluated using the Boston Bowel Preparation Scale (BBPS) (adequate cleansing ≥ 2 points per segment). Secondary outcomes were adherence to and level of satisfaction with the LRD, difficulty following the dietary recommendations, and willingness to repeat the same LRD in the future. Intention-to-treat (ITT) and per-protocol (PP) analyses were conducted for the primary outcome. A superiority analysis was performed to demonstrate that a 3-day LRD regimen was superior to a 1-day LRD regimen with a margin of 10 %. Results 390 patients (1-day LRD group = 196, 3-day LRD = 194) were included. The cleansing quality was not significantly different between the groups: ITT analysis 82.7 % (95 % confidence interval [CI] 77.4 to 88.0) vs. 85.6 % (95 %CI 80.7 to 90.5), with odds ratio (OR) 1.2 (95 %CI 0.72 to 2.15); PP analysis 85.0 % (95 %CI 79.9 to 90.1) vs. 88.6 % (95 %CI 84.0 to 93.2), with OR 1.4 (95 %CI 0.88 to 2.52). No differences were found regarding adherence to the diet or cleansing solution, satisfaction or difficulty with the LRD, and the polyp/adenoma detection rates. Conclusion 3-day LRD did not offer advantages over 1-day LRD in preparation for colonoscopy.
Abstract 20856: Dual Mitophagy and Necrosis Dependent Pathways Functionally Couple Mitochondrial Death Protein Bnip3 to Doxorubicin Cardiomyopathy
Authors: Lorrie A Kirshenbaum, Rimpy Dhingra, Matthew Guberman, Ruoyang Shi, Victoria Margulets, Hillary Nepon
Journal: Circulation (2017)

Autophagy is a homeostatic process by which damaged organelles such as mitochondria are degraded by an autophagosomal regulated pathway. Accordingly, excessive autophagy can be detrimental and prom...