tbuckley/cabot-search huggingface dataset:
Abstract 12608: Coronary Artery Plaque Burden Characterization in Psoriasis Reveals Increase in High Risk Plaque
Authors: Joseph B Lerman, Abhishek Chaturvedi, Amit K Dey, Tsion M Aberra, Aditya A Joshi, Mohammad T Kabbany, Taufiq Salahuddin, Raza Yunus, Joanna I Silverman, Justin A Rodante, Martin P Playford, Marcus Y Chen, Veit Sandfort, David A Bluemke, Nehal N Mehta
Journal: Circulation (2016)

Introduction: Psoriasis (PSO), a chronic inflammatory skin disease associated with increased risk of MI, provides an ideal translational human model to study inflammatory atherogenesis. The presence of high-risk plaque (HRP) by coronary-computed tomography angiography (CCTA) is associated with prospective CV events. To date, however, no study has characterized HRP morphology in PSO. Hypothesis: We hypothesized that PSO would associate with an increased prevalence of HRP, as compared to controls (HC). Methods: PSO (n=107), HC (n=25), and hyperlipidemic patients (HLD) (n=30) who were candidates for statin therapy under NCEP ATP III guidelines, underwent CCTA (Toshiba, 320-detector row) for coronary plaque characterization. Total and non-calcified plaque burden were quantified using QAngio (Medis). To characterize HRP, a single reviewer evaluated for positive remodeling index (&gt; 1.1), low-attenuation (&lt; 30 HU), and spotty calcification. Statistical analysis included multivariable regression. Results: PSO patients were middle-aged, male-predominant, and at low Framingham risk (Table). Non-calcified plaque burden was higher in PSO than in HC (p =0.05) and in HLD (p = 0.02). The prevalence of HRP was greater in PSO than in HC (34% vs. 8%, p=0.01), and was comparable to that seen in HLD (34% vs. 37%, p=0.78). Logistic regression revealed a significant association between PSO and the presence of HRP, beyond Framingham risk, BMI, glucose, and statins (OR 5.8, p= 0.03). This association, however, attenuated in HLD after adjustment (OR 2.6, p = 0.3). Conclusions: PSO associated with a higher prevalence of HRP, independent of traditional CV risk, and similar to that observed in HLD. These findings are consistent with the known association between PSO and MI, and may lend insight to the residual CV risk not captured by traditional methods in PSO. Larger studies are needed to confirm these results.
CAR22/19 Cocktail Therapy for Patients with Refractory/Relapsed B-Cell Malignancies
Authors: Liang Huang, Na Wang, Yang Cao, Chunrui Li, Yi Xiao, Min Xiao, Xiaoxi Zhou, Gaoxiang Wang, Zhenya Hong, Miao Zhen, Weixu Meng, Bin Zhang, Yicheng Zhang, Guido Marcucci, Tongcun Zhang, Jianfeng Zhou
Journal: Blood (2018)
Abstract 17035: Dose Response Relationship Between Sedentary Time and Cardiovascular Disease Risk: A Meta-analysis
Authors: Usman I Salahuddin, Ambarish Pandey, Colby R Ayers, Jacquelyn Kulinski, Sushil Garg, Dharam J Kumbhani, James A de Lemos, Jarett D Berry
Journal: Circulation (2015)

Background: Prior studies suggest that higher sedentary time is associated with greater risk for cardiovascular disease (CVD). However, the quantitative, dose-response relationship between sedentary time and CVD risk has not been reported. Methods: PUBMED and EMBASE were searched for prospective cohort studies that evaluated the associations between sedentary time and CVD risk(coronary heart disease, stroke, CVD mortality). The categorical dose response association was evaluated by comparing the pooled hazard ratio (HR) for CVD associated with different levels of sedentary time (vs. lowest sedentary time) across studies. The continuous dose response was assessed among studies that allowed quantitative estimation of sedentary time using random effects generalized least squares spline models. Results: Nine prospective cohort studies with 561,305 participants (54.3% women) and 24,423 incident CVD events over a median follow up of 11 years were included in the meta-analysis. In categorical analysis, compared with the lowest sedentary time category median: (2 hr/day), participants in the highest sedentary time category median: (11.5 hr/day) had an increased risk for CVD [Hazard Ratio (HR) 95% CI: 1.15 (1.11 - 1.20)]. However, there was no apparent risk associated with intermediate levels of sedentary time [Second Highest Category (median 8.1 hr/day): HR (95%CI)= 0.99 (0.96 - 1.03);Third Highest Category (median 5.1 hr/day): HR (95%CI)= 1.06 (0.98 - 1.05)]. In continuous analyses, there was a non-linear relationship between sedentary time and CVD (p-value for non-linearity: 0.0001), with an increased risk for CVD observed for more than 10 hours/day of sedentary time [Pooled HR: 1.07 (1.00 to 1.14), Figure]. Conclusion: CVD risk associated with sedentary time is non-linear with an increased risk only at very high levels (&gt; 10 hr/day). These findings could have implications for future guideline recommendations regarding the risks related to sedentary behavior.
Gastroschisis and Autism—Dual Canaries in the Californian Coalmine—Reply
Authors: Jamie Anderson, Shinjiro Hirose
Journal: JAMA Surgery (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
CHANGES IN AORTIC-MITRAL COUPLING IN SEVERE AORTIC STENOSIS
Authors: Wendy Tsang, Lissa Sugeng, Federico Veronesi, Masaaki Takeuchi, Vallulan Jeevanandam, Jai Raman, Lynn Weinert, Victor Mor-Avi, Roberto M. Lang
Journal: Journal of the American College of Cardiology (2011)
Abstract 19426: DMGV is Associated With Cardiometabolic Traits and Predicts Incident Coronary Artery Disease
Authors: Jordan E Morningstar, Yan Gao, Debby Ngo, John F O'Sullivan, Laurie Farrell, Clary B Clish, Thomas J Wang, James Wilson, Robert E Gerszten
Journal: Circulation (2017)

Background: We previously identified α-keto-δ-(NGNG-dimethylguanidino)-valeric acid (DMGV) as a novel marker of CT-defined liver fat. DMGV is a poorly characterized transamination product of asymme...
Correction to: RNA G-quadruplexes at upstream open reading frames cause DHX36- and DHX9-dependent translation of human mRNAs
Authors: Pierre Murat, Giovanni Marsico, Barbara Herdy, Avazeh T. Ghanbarian, Guillem Portella, Shankar Balasubramanian
Journal: Genome biology (2019)

Following publication of the original article [1], the authors reported the following error in the name of the fourth author.
Nilotinib (Tasigna®) and Low Intensity Chemotherapy for First-Line Treatment of Elderly Patients with BCR-ABL1-Positive Acute Lymphoblastic Leukemia: Final Results of a Prospective Multicenter Trial (EWALL-PH02)
Authors: Oliver G. Ottmann, Heike Pfeifer, Jean-Michel Cayuela, Karsten Spiekermann, Wolfram Jung, Joachim Beck, Emmanuel Raffoux, Pascal Turlure, Chantal Himberlin, Francoise Huguet, Andreas Viardot, Knut Wendelin, Albrecht Reichle, Sébastien Maury, Laurence Sanhes, Francoise Isnard, Jean-Yves Cahn, Stephane Lepretre, Patrice Chevallier, Martine Escoffre-Barbe, Josep-Maria Ribera, Dieter Hoelzer, Nicola Goekbuget, Hervé Dombret, Philippe Rousselot
Journal: Blood (2018)
Performance of the Centers for Medicare &amp; Medicaid Services’ Opioid Overutilization Criteria for Classifying Opioid Use Disorder or Overdose
Authors: Yu-Jung Jenny Wei, Cheng Chen, Amir Sarayani, Almut G. Winterstein
Journal: JAMA (2019)

This study characterizes the accuracy of CMS' Overutilization Monitoring System for correctly identifying prescription opioid users at risk of opioid use disorder (OUD) or overdose between 2011 and 2014.
Abstract P115: Better Methodologies to Compare Coronary Heart Disease Mortality Trends in Latin American Countries: Argentina, Colombia and Mexico From 1985 to 2012
Authors: Maria C Arroyo Quiroz, Martin O’Flaherty, Hector Lamadrid-Figueroa, Maria L Guzman-Castillo, Simon Capewell, Tonatiuh Barrientos-Gutierrez
Journal: Circulation (2017)

Introduction: Coronary heart disease (CHD) is the leading cause of death worldwide. CHD mortality rates have decreased in most high-income countries, but increased in some Latin-American countries. CHD mortality rates have plateaued among young adults (&lt;55 years) in the US, UK and Australia, but trends in Latin-America are largely unknown. Few studies have analyzed trends in age and sex-specific CHD mortality rates in this region, and almost none has assured data quality by correcting for garbage codes (ICD codes for nonspecific causes of death) as recommended by WHO. Objective: To describe and compare standardized, age-specific and garbage-code corrected mortality trends for coronary heart disease (CHD) from 1985 to 2012 in three contrasting Latin American countries. Methods: CHD deaths (1985-2012) in Argentina, Colombia and Mexico were grouped by calendar year, sex and 10-year age bands to calculate the overall age-adjusted and age and sex specific mortality rates for adults aged ≥25 years. We corrected for garbage-codes for the three countries (1997-2012) using the Global Burden of Disease (GBD) methodology. We then fitted Joinpoint regression models, using the original and garbage code corrected rates, to estimate the annual percent change (APC) and detect points in time when significant changes in the trends occurred. Results: In 2012, age-standardised mortality rates per 100,000 were 65.3 in Argentina, 132.4 in Colombia and 130.3 in Mexico. Compared to 1985, by 2012 mortality fell by 17.5% in Colombia and 52.5% in Argentina. The largest annual decreases in mortality rates were observed in Argentina from 1988-1994 (APC=-5.7 p-value&lt;0.01). The declines in Colombia were constant and smaller for the full period (APC=-0.4 p-value&lt;0.01). CHD mortality rose by 48.9% in Mexico, particularly after 2000. Mortality rates increased in both men and women, particularly in younger men (&lt;39 years) and older women (&gt;60 years). Application of the garbage code corrections produced dramatic increases in mortality rates, more in women than men, and particularly in Argentina: approximately 80 additional deaths per 100,000 (compared with just 14 additional deaths per 10 5 in Colombia and 13 per 10 5 in Mexico). Conclusions: Different Latin American countries demonstrate dramatically different CHD epidemiology. Mortality rates increased after correcting for garbage code misclassification. Although CHD mortality is falling in Argentina, the modest falls in Colombia and substantial rises in Mexico highlight the region’s urgent need for effective, population-wide prevention policies.
Specific Decrease in B-Cell-Derived Extracellular Vesicles Enhances Post-Chemotherapeutic CD8+ T Cell Responses
Authors: Fanghui Zhang, Rongrong Li, Yunshan Yang, Chunhui Shi, Yingying Shen, Chaojie Lu, Yinghu Chen, Wu Zhou, Aifu Lin, Lei Yu, Wanjing Zhang, Zhenwei Xue, Jianli Wang, Zhijian Cai
Journal: Immunity (2019)
Effectiveness Of Elastic Tube Resistance Training On 6-Minute Walk Test And Muscle Force In Patients With COPD: A Randomized Control Trial
Authors: C. A. Camillo, B. S. Silva, F. Lima, A. Freire, L. A. Gobbo, F. Lira, D. Ramos, E. M. Ramos
Journal: American Journal of Respiratory and Critical Care Medicine (2016)
Further Progress for Patients with Breast Cancer
Authors: Daniel F. Hayes
Journal: New England Journal of Medicine (2019)

Substantial progress has been made over the past 50 years in the evaluation and treatment of patients with breast cancer, leading to a nearly 40% decrease in mortality from this disease and associated reductions in complications of treatment.1 This progress has occurred with the understanding that breast cancer is not one but several diseases with biologically driven subtypes.2 Each of these subtypes is amenable to different treatment strategies, so that a personalized-medicine approach is possible in the treatment of patients with breast cancer. For example, endocrine treatment in women with estrogen-receptor–positive, but not estrogen-receptor–negative, breast cancer has led to considerable . . .
A biologic scaffold–associated type 2 immune microenvironment inhibits tumor formation and synergizes with checkpoint immunotherapy
Authors: Matthew T. Wolf, Sudipto Ganguly, Tony L. Wang, Christopher W. Anderson, Kaitlyn Sadtler, Radhika Narain, Christopher Cherry, Alexis J. Parrillo, Benjamin V. Park, Guannan Wang, Fan Pan, Saraswati Sukumar, Drew M. Pardoll, Jennifer H. Elisseeff
Journal: Science Translational Medicine (2019)

Biologic scaffolds synergize with immune checkpoint blockade to inhibit tumor growth in mice in a process requiring T cells and macrophages.
BAR-Bodies: B-Cell Receptor Antigens As the Targeting Moiety of Antibodies in Substitution for the Variable Region of Heavy and Light Chains
Authors: Moritz Bewarder, Lorenz Thurner, Frank Neumann, Natalie Fadle, Evi Regitz, Maria Kemele, Helene Will, Lisa Goerens, Konstantinos Christofyllakis, Dominic Kaddu-Mulindwa, Stephan Stilgenbauer, Maximilian Kiefer, Klaus Dieter Preuss
Journal: Blood (2018)
App Aids Treatment Retention for Opioid Use Disorder
Authors: Rebecca Voelker
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Unified Classification of Molecular, Network, and Endocrine Features of Hypothalamic Neurons
Authors: Roman A. Romanov, Alán Alpár, Tomas Hökfelt, Tibor Harkany
Journal: Annual Review of Neuroscience (2019)

Peripheral endocrine output relies on either direct or feed-forward multi-order command from the hypothalamus. Efficient coding of endocrine responses is made possible by the many neuronal cell types that coexist in intercalated hypothalamic nuclei and communicate through extensive synaptic connectivity. Although general anatomical and neurochemical features of hypothalamic neurons were described during the past decades, they have yet to be reconciled with recently discovered molecular classifiers and neurogenetic function determination. By interrogating magnocellular as well as parvocellular dopamine, GABA, glutamate, and phenotypically mixed neurons, we integrate available information at the molecular, cellular, network, and endocrine output levels to propose a framework for the comprehensive classification of hypothalamic neurons. Simultaneously, we single out putative neuronal subclasses for which future research can fill in existing gaps of knowledge to rationalize cellular diversity through function-determinant molecular marks in the hypothalamus.
Generation of Half-Life Extended Anti-BCMA Bite® Antibody Construct Compatible with Once-Weekly Dosing for Treatment of Multiple Myeloma (MM)
Authors: Ana Goyos, Chi-Ming Li, Petra Deegen, Pamela Bogner, Oliver Thomas, Klinger Matthias, Joachim Wahl, Rebecca Goldstein, Angela Coxon, Mercedesz Balazs, Tara Chapman-Arvedson
Journal: Blood (2017)
Identification of Tipifarnib Sensitivity Biomarkers in T-Cell Tumor Cell Lines
Authors: Ruth Alonso Alonso, Rufino Mondejar García, Jose Pedro Vaqué Díez, Nuria García Díaz, Cristina Pérez Menéndez, Francis Burrows, Catherine Scholz, Antonio Gualberto, Miguel A. Piris
Journal: Blood (2018)
Abstract 14782: Incidence and Characteristics of Pulmonary Vein Stenosis Following Catheter Ablation of Atrial Fibrillation: Insights From the Contemporary Multicenter ADVICE Trial
Authors: Sophie Gomes, Paul Khairy, Jason Andrade, Stanley Nattel, Mario Talajic, Peter G Guerra, Lena RIvard, Marc Dubuc, Katia Dyrda, Bernard Thibault, Blandine Montdesert, Sylvie Levesque, Rafik Tadros, Nicolas Malliet, Sandrine Venier, Catherine Millette, Denis Roy, Laurent Macle
Journal: Circulation (2014)

Introduction: Pulmonary vein (PV) stenosis is a well-described complication of atrial fibrillation (AF) ablation. Available data regarding the incidence of pulmonary vein (PV) stenosis associated with radiofrequency catheter ablation of AF are limited to surveys, single-center studies, and small trials. We prospectively assessed the incidence of PV stenosis after catheter ablation of AF in the context of a large randomized multicenter international study (ADVICE). Methods: Patients undergoing a first PV isolation procedure for the treatment of symptomatic paroxysmal AF were enrolled from 13 centers. PV isolation was performed by encircling all PVs using an irrigated-tip radiofrequency ablation catheter guided by a circular mapping catheter with the endpoint of electrical PV isolation. Systematic imaging of the left atrium and PVs using computed tomography-scan (CT-Scan) or magnetic resonance (MRI) was performed at 90 days post ablation to assess the incidence of PV stenosis. Significant PV stenosis was defined by a narrowing of PV luminal diameter greater than 70% as per Heart Rhythm Society guidelines. The incidence of moderate PV stenosis defined by a narrowing between 50% and 70% was also analyzed. Predictors of PV stenosis were explored by logistic regression analyses. Results: A total of 197 patients (mean age 59±9 yrs, 71% male) were included in this study. Electrical PV isolation was achieved in all patients. On the post ablation imaging study (performed at a mean of 103±33 days post ablation), a significant PV stenosis was observed in 1.52% [95% confidence interval (0.00%-3.23%)] of patients. In addition, a moderate PV stenosis was seen in 3.55% [95% confidence interval (0.97%-6.14%)] of patients. The affected PVs included 8 left inferior PVs, 1 right inferior and 1 right middle PV. None of the patients were symptomatic or required an intervention related to the PV stenosis. The presence of PV stenosis could not be predicted by clinical, hemodynamic, or procedural parameters. Conclusions: Our systematic evaluation of the incidence of PV stenosis in the context of a prospective multinational trial confirms previously reported low rates of significant PV stenosis following radiofrequency catheter ablation of AF.
Abstract 20914: Characteristics and the Average 30-Day and 6-Month Clinical Outcomes of Patients With Coronary Heart Disease in a Resource-Limited Indonesian Setting
Authors: Andriany Qanitha, Cuno S Uiterwaal, Abdul H Alkatiri, Idar Mappangara, Bastianus A de Mol
Journal: Circulation (2017)

Background: Little is known about characteristics at admission and mid-term outcomes of patients with coronary heart disease (CHD) in a resource-limited South-East Asian setting. We aimed to provide a detailed description of characteristics at hospital admission of patients hospitalized with CHD from a poor setting of Indonesian population and of their clinical outcomes at 30-day and 6-month follow-up. Methods: We performed a cohort study of 477 patients diagnosed with CHD (acute coronary syndrome and stable coronary artery disease) admitted at the Makassar Cardiac Center, Indonesia, between February 2013 and December 2014. The outcomes, obtained by active follow-up, were all-cause mortality and major adverse cardiovascular events (MACE). Results: Out of 477 CHD patients, the proportion of young age (&lt;60 years) was 53.9% and 72.7% were male. At admission, 44.2% of patients were diagnosed with ST-elevation myocardial infarction (STEMI), 38.6% with diagnosis or signs of heart failure, and 75.1% had previous hypertension. Out of 211 STEMI patients, only 4.7% had been treated by primary PCI and 6.2% received thrombolysis. The time lapse from symptom onset to hospital admission was 26.8 hours (IQR 10.0-48.0), and only 20.1% of all patients had undergone either PCI or CABG. The survival rate at 6 months was 78.9%. The rates of all-cause mortality in hospital, at 30 days, and 6 months were 10.9%, 2.5%, and 7.3%, respectively; the rate of MACE at 30 days was 14.9% and at 6 months was 17.8%. Conclusions: Patients with CHD in a resource-limited Indonesian setting are predominantly young males, present late after chest pain onset, and rarely receive guideline-recommended therapy. During 6-month follow-up, more than a third of these CHD patients have adverse clinical outcomes.
Comparative effectiveness study of face-to-face and teledermatology workflows for diagnosing skin cancer
Authors: Sangeeta S. Marwaha, Helene Fevrier, Stacey Alexeeff, Eileen Crowley, Michael Haiman, Ngoc Pham, Melanie J. Tuerk, Danny Wukda, Michael Hartmann, Lisa J. Herrinton
Journal: Journal of the American Academy of Dermatology (2019)