AB0731 RATE OF SACROILIITIS RADIOGRAPHIC PROGRESSION IN MALE AND FEMALE PATIENTS WITH EARLY AXIAL SPONDYLOARTHRITIS
Authors: Daria Rumiantceva, Tatiana Dubinina, Anastasiya Demina, Shandor Erdes
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> According recent studies radiographic progression (mSASSS) of male patients (pts) with ankylosing spondylitis (AS) higher than in female pts [1, 2]. Objectives: to compare radiographic progression of early axial spondyloarthritis (axSpA) in male and female pts over 2 years (y) of follow-up (FUP). <h3>Methods</h3> The research included 68 pts with early axSpA (ASAS criteria, 2009) from Moscow CORSAR cohort with disease duration &lt;5 and age onset &lt;45 years. The mSASSS index is not suitable for assessing radiographic progression at an early stage of axSpA, because at that stage of the disease, the cervical and lumbar spine have practically no damage. Sacroiliac joints (SIJ) radiographs and CRP performed at baseline and after 2 y FUP. Radiographic SIJ stages scored according to the modified New York criteria grading system. To assess the progression in SIJ, total stage of sacroiliitis (TSS) calculated, by determining sum score stages of sacroiliitis (SI) in the left and right SIJ (from 0 to 8 points). The following formula used to calculate the rate of SI radiographic progression: *TSS¹ - initial total score stages of SI, TSS² - FUP total score stages of SI Pts mean age was 28,5 (5,8) y, average disease duration - 24,1 (15,4) mo, 63 (92,6%) pts were HLA-B27 positive. <h3>Results</h3> Initially, among men there were more pts with aS than among women and they had a higher TSS and higher CRP level (table 1). Rate of SI radiographic progression in male and female pts with axSpA at baseline did not differ. After 2 y FUP, pts with aS still prevailed among men (table 2). TSS increased in both groups: in female pts from 3[2,0; 4,0] to 4 [3,0; 4,0] (p&lt;0,05), in male pts from 4,0 [4,0; 5,0] to 4 [4,0; 6,0] (p&lt;0,05). But, however, in female pts TSS remained less than in male pts over 2 y FUP (table 2). CRP level still was higher in male pts (p &lt;0,05). Progression from non-radiographic axSpA to aS between male and female pts didn't differ - 5 (15,5%) vs 6 (17,2%), p&gt;0,05 respectively, after 2 y FUP. In both groups rate of SI radiographic progression after 2 y decreased (p&lt;0,05) and did not differ between them. <h3>Conclusion</h3> 1. Rate of SI radiographic progression in male and female pts with axSpA in the first 2 y from the onset of disease is higher than in further. 2. Rate of SI radiographic progression between male and female pts with axSpA is not differ. 3. Male pts with aS more than female pts in CORSAR cohort. It can be explained that male pts had higher CRP level than female pts. <h3>References</h3> [1] Baraliakos X, et al. The natural course of radiographic progression in ankylosing spondylitis: differences between genders and appearance of characteristic radiographic features. Current rheumatology reports2011;13(5):383. [2] Rudwaleit, M. et al. The early disease stage in axial spondylarthritis: results from the German Spondyloarthritis inception Cohort. Arthritis &amp; Rheumatism: official Journal of the american College of Rheumatology 2009;60(3):717-727. <h3>Disclosure of interests</h3> Daria Rumiantceva: None declared, Tatiana Dubinina: None declared, anastasiya Demina: None declared, Shandor Erdes Consultant for: Development of studies concepts., Speakers bureau: Educational meetings organized or supported by companies.