tbuckley/cabot-search huggingface dataset:
Prognostic Importance of Premature Beats Following Myocardial Infarction
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Growth differentiation factor-15 as a biomarker of strength and recovery in survivors of acute respiratory failure
Authors: Brian J Rosenberg, Michio Hirano, Catarina M Quinzii, Elizabeth Colantuoni, Dale M Needham, David J Lederer, Matthew R Baldwin
Journal: Thorax (2019)

Muscle mitochondrial dysfunction is implicated in intensive care unit-acquired weakness, but there is no serum biomarker of muscle mitochondrial function for critical illness survivors. Higher serum growth differentiation factor-15 (GDF-15) is a biomarker of inherited mitochondrial myopathy disease and is associated with mortality in several age-related diseases. Among 142 older (age ≥ 65 years) survivors of acute respiratory failure, we found that higher serum GDF-15 measured during the week prior to hospital discharge was cross-sectionally associated with weaker diaphragm, limb and hand-grip strength, and longitudinally associated with lower rates of functional recovery over 6 months, independent of age, sex, pre-existing disability, comorbidity, frailty, Acute Physiology and Chronic Health Evaluation II scores and concurrent interleukin-6 levels.
Health Education and the Nutrition Class.
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Varun Kumar Singh
Authors: Sue Singh-Levett
Journal: BMJ (2019)

Varun Kumar Singh was born in Akbarpur, Uttar Pradesh, India, on 26 April 1948. He was the middle child of five of a well known Hindi poet and academic, Shiv Mangal Singh (“Suman”), and Shanti Devi Singh. He had severe asthma from a young age and moved several times during his childhood because of his father’s work. Despite this, he finished his schooling in Ujjain, Madhya Pradesh, in 1964 and moved to Indore to start medical school. He completed his training in 1974 …
Trends in Adolescent Vaping, 2017–2019
Authors: Richard Miech, Lloyd Johnston, Patrick M O'Malley, Jerald G Bachman, Megan E Patrick
Journal: New England Journal of Medicine (2019)

Vaping Trends among Adolescents, 2017–2019 Vaping by adolescents is a concern because of the risks of nicotine addiction and because of reports of an association between vaping and acute lung injur...
Suppressive antibiotic therapy in prosthetic joint infections: a multicentre cohort study
Authors: R. Escudero-Sanchez, E. Senneville, M. Digumber, A. Soriano, M.D. del Toro, A. Bahamonde, J.L. del Pozo, L. Guio, O. Murillo, A. Rico, M.J. García-País, D. Rodríguez-Pardo, J.A. Iribarren, M. Fernández, N. Benito, G. Fresco, A. Muriel, J. Ariza, J. Cobo
Journal: Clinical Microbiology and Infection (2019)
A novel lymphoma-associated macrophage interaction signature (LAMIS) provides robust risk prognostication in diffuse large B-cell lymphoma clinical trial cohorts of the DSHNHL
Authors: Annette M. Staiger, Michael Altenbuchinger, Marita Ziepert, Christian Kohler, Heike Horn, Michael Huttner, Katrin S. Hüttl, Gunther Glehr, Wolfram Klapper, Monika Szczepanowski, Julia Richter, Harald Stein, Alfred C. Feller, Peter Möller, Martin-Leo Hansmann, Viola Poeschel, Gerhard Held, Markus Loeffler, Norbert Schmitz, Lorenz Trümper, Tobias Pukrop, Andreas Rosenwald, German Ott, Rainer Spang
Journal: Leukemia (2019)
Retooling a Blood-Based Biomarker: Phase I Assessment of the High-Affinity CA19-9 Antibody HuMab-5B1 for Immuno-PET Imaging of Pancreatic Cancer
Authors: Christian Lohrmann, Eileen M. O'Reilly, Joseph A. O'Donoghue, Neeta Pandit-Taskar, Jorge A. Carrasquillo, Serge K. Lyashchenko, Shutian Ruan, Rebecca Teng, Wolfgang Scholz, Paul W. Maffuid, Jason S. Lewis, Wolfgang A. Weber
Journal: Clinical Cancer Research (2019)

In patients with cancer who have an abnormal biomarker finding, the source of the biomarker in the bloodstream must be located for confirmation of diagnosis, staging, and therapy planning. We evaluated if immuno-PET with the radiolabeled high-affinity antibody HuMab-5B1 (MVT-2163), binding to the cancer antigen CA19-9, can identify the source of elevated biomarkers in patients with pancreatic cancer.In this phase I dose-escalating study, 12 patients with CA19-9-positive metastatic malignancies were injected with MVT-2163. Within 7 days, all patients underwent a total of four whole-body PET/CT scans. A diagnostic CT scan was performed prior to injection of MVT-2163 to correlate findings on MVT-2163 PET/CT.Immuno-PET with MVT-2163 was safe and visualized known primary tumors and metastases with high contrast. In addition, radiotracer uptake was not only observed in metastases known from conventional CT, but also seen in subcentimeter lymph nodes located in typical metastatic sites of pancreatic cancer, which were not abnormal on routine clinical imaging studies. A significant fraction of the patients demonstrated very high and, over time, increased uptake of MVT-2163 in tumor tissue, suggesting that HuMab-5B1 labeled with beta-emitting radioisotopes may have the potential to deliver therapeutic doses of radiation to cancer cells.Our study shows that the tumor antigen CA19-9 secreted to the circulation can be used for sensitive detection of primary tumors and metastatic disease by immuno-PET. This significantly broadens the number of molecular targets that can be used for PET imaging and offers new opportunities for noninvasive characterization of tumors in patients.
Neutrophil Extracellular Traps Accelerate Cholestatic Liver Injury through Bile Acids in Bile Duct Ligation Mice
Authors: Yan Zhang, Zhipeng Yao, Tao Li, Muhua Cao, Ruishuang Ma, Xiaoming Wu, Lixiu Wang, Lu Zhao, Yayan Bi, Junjie Kou, Jin Zhou, Jialan Shi
Journal: Blood (2016)
Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction
Authors: Sifan Chen, Ayana Henderson, Michael C. Petriello, Kymberleigh A. Romano, Mary Gearing, Ji Miao, Mareike Schell, Walter J. Sandoval-Espinola, Jiahui Tao, Bingdong Sha, Mark Graham, Rosanne Crooke, Andre Kleinridders, Emily P. Balskus, Federico E. Rey, Andrew J. Morris, Sudha B. Biddinger
Journal: Cell Metabolism (2019)
Sixty seconds on . . . prostate testing
Authors: Nigel Hawkes
Journal: BMJ (2019)

Don’t rush your fences. The research from Queen Mary University of London is encouraging but there’s a way to go yet.

Used in combination with the prostate specific antigen (PSA) test, sifting out circulating tumour cells from the bloodstream and analysing them could help predict aggressive prostate cancer.1 That could mean that fewer men would need biopsies and …
Erratum: miR-194-5p/BCLAF1 deregulation in AML tumorigenesis
Authors: C Dell'Aversana, C Giorgio, L D'Amato, G Lania, F Matarese, S Saeed, A Di Costanzo, V Belsito Petrizzi, C Ingenito, J H A Martens, I Pallavicini, S Minucci, A Carissimo, H G Stunnenberg, L Altucci
Journal: Leukemia (2017)
Generation of mouse models to study the contribution of Mdmx to p53 pathway activation
Authors: Yunyuan Wang, Geoffrey Wahl
Journal: Cancer Research (2008)

5806  The p53 tumor suppressor is a stress-activated transcription factor that is functionally inactivated in most if not all human cancers. One important mechanism for p53 inactivation concerns over-expression of either of its two negative regulators, the related RING domain proteins Mdm2 and MdmX. Mdm2 is an E3 ubiquitin ligase that mediates degradation of itself and p53 in unstressed cells to keep p53 activity low, but after DNA damage, the E3 ligase function switches so that Mdm2 preferentially targets itself and MdmX to simultaneously remoce both negative regulators and enable p53 to accumulate and transcriptionally regulate its target genes. In vitro studies suggest that the switch in substrate preference is mediated in part by dmage-kinase mediated phosphorylation of multiple conserved serine residues in MdmX.  To understand how the post-translational modifications in Mdmx contribute to p53 stabilization, target gene regulation, and tumor suppression in vivo, we generated knock-in mice in which serines 341, 367 and 402 in MdmX were replaced with alanines. Mice homozygous for the MdmX triple mutant were born without any developmental defects, and thus far, at the expected Mendelian ratio. The mutant Mdmx was more stable than wild type Mdmx to DNA damage, but was still partially destabilized, implying the existence of additional sites for damage induced modifications that affect its stability. The stabilized mutant MdmX compromised p53 and Mdm2 accumulation, the latter due to decreased p53 transactivation of the Mdm2 gene. The response of MEFs encoding the mutant MdmX to irradiation was also reduced, which corresponds with a reduced efficiency of p53 mediated transactivation of the p21 gene. Additional studies currently in progress will evaluate the response to activated oncogenes in vivo and in vitro, as well as p53 responses in different tissues. Thus far, the data reveal a linkage between the control of MdmX stability after DNA damage and the ability to regulate the stability and activity of p53. These data reinforce the importance of MdmX in control of p53 function, and as a potential therapeutic target.
Inhibition of the C5a-C5aR Axis By the L-Aptamer Aon-D21 As a New Strategy to Ameliorate Uncontrolled Migration/Motility of Hematopoietic Stem Cells - Potential Therapeutic Implications for Paroxysmal Nocturnal Hemoglobinuria
Authors: Kamila Bujko, Sylwia Rzeszotek, Janina Ratajczak, Kai Hoehlig, Axel Vater, Mariusz Z Ratajczak
Journal: Blood (2017)
Effect of Intrinsic Patterns of Functional Brain Connectivity in Moderating Antidepressant Treatment Response in Major Depression
Authors: Cherise R. Chin Fatt, Manish K. Jha, Crystal M. Cooper, Gregory Fonzo, Charles South, Bruce Grannemann, Thomas Carmody, Tracy L. Greer, Benji Kurian, Maurizio Fava, Patrick J. McGrath, Phillip Adams, Melvin McInnis, Ramin V. Parsey, Myrna Weissman, Mary L. Phillips, Amit Etkin, Madhukar H. Trivedi
Journal: American Journal of Psychiatry (2019)

Objective: Major depressive disorder is associated with aberrant resting-state functional connectivity across multiple brain networks supporting emotion processing, executive function, and reward processing. The purpose of this study was to determine whether patterns of resting-state connectivity between brain regions predict differential outcome to antidepressant medication (sertraline) compared with placebo. Methods: Participants in the Establishing Moderators and Biosignatures of Antidepressant Response in Clinical Care (EMBARC) study underwent structural and resting-state functional MRI at baseline. Participants were then randomly assigned to receive either sertraline or placebo treatment for 8 weeks (N=279). A region of interest–based approach was utilized to compute functional connectivity between brain regions. Linear mixed-model intent-to-treat analyses were used to identify brain regions that moderated (i.e., differentially predicted) outcomes between the sertraline and placebo arms. Results: Prediction of response to sertraline involved several within- and between-network connectivity patterns. In general, higher connectivity within the default mode network predicted better outcomes specifically for sertraline, as did greater between-network connectivity of the default mode and executive control networks. In contrast, both placebo and sertraline outcomes were predicted (in opposite directions) by between-network hippocampal connectivity. Conclusions: This study identified specific functional network–based moderators of treatment outcome involving brain networks known to be affected by major depression. Specifically, functional connectivity patterns of brain regions between and within networks appear to play an important role in identifying a favorable response for a drug treatment for major depressive disorder.
Abstract P170: Lung Function Associated with Long-term Blood Pressure Variability in Young Adults: The Coronary Artery Risk Development in Young Adults Study
Authors: Yacob G Tedla, Yuichiro Yano, Bharat Thyagarajan, Ravi Kalhan, Rajesh Kumar, Anthony Viera, Sharon Rosenberg, Philip Greenland, Mercedes Carnethon
Journal: Circulation (2016)

Introduction: Long-term blood pressure variability (BPV) has been shown to be associated with target-organ damage independent of mean BP. However, little is known about the factors that determine long-term BPV. Reduced lung function is associated with incidence of hypertension and may also predict long-term BPV. Objective: To investigate the association between lung function and future long-term variability in systolic and diastolic BP among young adults. Methods: We used data from Coronary Artery Risk Development in Young Adults Study among 3318 participants (mean age 26.4 years, 35% Males at baseline). Lung function was measured by forced vital capacity (FVC - the amount of air that can be maximally and forcibly expelled from the lungs after a maximal inhalation) at years 0, 2, 5, 10, and 20. BPV was measured using: i) average real variability (ARV) - mean of the absolute differences in BP between successive visits and ii) standard deviation (SD) of BP from years 0 to 25. In separate multiple linear regression models, ARV and SD of systolic and diastolic BP were regressed on quartiles and continuous variables of baseline FVC and FVC change from peak value to year 10 value. Results: ARV and SD of systolic and diastolic BPs were significantly lower among participants with higher baseline FVC (quartiles 2, 3 and 4) as compared to those in quartile 1 after adjusting for mean BP and other confounders. Similarly, individuals who showed greater decline in FVC from peak to year 10 value (quartiles 3 and 4) showed significant higher ARV and SD of systolic and diastolic BPs as compared to those in quartile 1. Similar results were found when FVC was used as a continuous variable. There was significant trend in the association of long-term BPV with quartiles of baseline FVC and FVC change from peak to year 10 value (Table 1). Conclusion: Among young adults, lower baseline FVC and higher decline in FVC over time was associated with higher long-term BPV independent of mean BP. Deterioration in lung function seems to be an independent risk factor for long-term BPV.
Soluble Signals and Remodeling in a Synthetic Gelatin‐Based Hematopoietic Stem Cell Niche
Authors: Aidan E. Gilchrist, Sunho Lee, Yuhang Hu, Brendan A. C. Harley
Journal: Advanced Healthcare Materials (2019)

Abstract Hematopoietic stem cells (HSCs) reside in the bone marrow within niches that provide microenvironmental signals in the form of biophysical cues, bound and diffusible biomolecules, and heterotypic cell–cell interactions that influence HSC fate decisions. This study seeks to inform the development of a synthetic culture platform that promotes ex vivo HSC expansion without exhaustion. A library of methacrylamide‐functionalized gelatin (GelMA) hydrogels is used to explore remodeling and crosstalk from mesenchymal stromal cells (MSCs) on the expansion and quiescence of murine HSCs. The use of a degradable GelMA hydrogel enables MSC‐mediated remodeling, yielding dynamic shifts in the matrix environment over time. An initially low‐diffusivity hydrogel for co‐culture of hematopoietic stem and progenitor cells to MSCs facilitates maintenance of an early progenitor cell population over 7 days. Excitingly, this platform promotes retention of a quiescent HSC population compared to HSC monocultures. These studies reveal MSC‐density–dependent upregulation of MMP‐9 and changes in hydrogel mechanical properties (Δ E = 2.61 ± 0.72) suggesting MSC‐mediated matrix remodeling may contribute to a dynamic culture environment. Herein, a 3D hydrogel is reported for ex vivo HSC culture, in which HSC expansion and quiescence is sensitive to hydrogel properties, MSC co‐culture, and MSC‐mediated hydrogel remodeling.
Hungry for your alanine: when liver depends on muscle proteolysis
Authors: Theresia Sarabhai, Michael Roden
Journal: Journal of Clinical Investigation (2019)

Fasting requires complex endocrine and metabolic interorgan crosstalk, which involves shifting from glucose to fatty acid oxidation, derived from adipose tissue lipolysis, in order to preserve glucose for the brain. The glucose-alanine (Cahill) cycle is critical for regenerating glucose. In this issue of JCI, Petersen et al. report on their use of an innovative stable isotope tracer method to show that skeletal muscle-derived alanine becomes rate controlling for hepatic mitochondrial oxidation and, in turn, for glucose production during prolonged fasting. These results provide new insight into skeletal muscle-liver metabolic crosstalk during the fed-to-fasting transition in humans.
Death by a thousand cuts
Authors: M. Joseph
Journal: BMJ (1982)

<h3>Objectives</h3> Measure patient safety culture in homecare services; test the psychometric properties of the Nursing Home Survey on Patient Safety Culture (NHSOPSC) instrument; and propose a short-version Homecare Services Survey on Patient Safety Culture instrument for use in homecare services. <h3>Design</h3> Cross-sectional survey with psychometric testing. <h3>Setting</h3> Twenty-seven publicly funded homecare units in eight municipalities (six counties) in Norway. <h3>Participants</h3> Five-hundred and forty health personnel working in homecare services. <h3>Interventions</h3> Not applicable. <h3>Primary and secondary outcome measures</h3> Primary: Patient safety culture assessed using the NHSOPSC instrument. Secondary: Overall perception of service users’ safety, service safety and overall care. <h3>Methods</h3> Psychometric testing of the NHSOPSC instrument using factor analysis and optimal test assembly with generalised partial credit model to develop a short-version instrument proposal. <h3>Results</h3> Most healthcare personnel rated patient safety culture in homecare services positively. A 19-item short-version instrument for assessing patient safety culture had high internal consistency, and was considered to have sufficient concurrent and convergent validity. It explained a greater proportion of variance (59%) than the full version (50%). Short-version factors included safety improvement actions, teamwork, information flow and management support. <h3>Conclusion</h3> This study provides a first proposal for a short-version Homecare Services Survey on Patient Safety Culture instrument to assess patient safety culture within homecare services. It needs further improvement, but provides a starting point for developing an improved valid and reliable short-version instrument as part of assessment of patient safety and quality improvement processes.
Pelvic Organ Prolapse
Authors: Cynthia A. Brincat
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cannabinoid hyperemesis syndrome: implications for pregnancy
Authors: Alain Braillon, Susan Bewley
Journal: BMJ (2019)

The article about cannabinoid hyperemesis syndrome as part of the Easily Missed? series is most welcome as “a way to help doctors . . . recognise conditions that are underdiagnosed or serious if not spotted.” 12

Awareness is inevitably low considering this syndrome was first described in 2004.3 It will be increasingly prevalent as cannabis use grows owing …