FRI0456 THE EFFECT OF GENDER ON DISEASE ACTIVITY, FUNCTIONAL INDEX AND QUALITY OF LIFE IN PATIENTS WITH AXIAL SPA. THE DATA OF TLAR-NETWORK PSA STUDY
Authors: Kemal Nas, Erkan Kilic, Ibrahim Tekeoğlu, Remzi Cevik, Betul Sargin, Sevtap Acer Kasman, Hakan Alkan, Nilay Sahin, Gizem Cengiz, Nihan Cuzdan, Ilknur Albayrak Gezer, Dilek Keskin, Cevriye Mülkoğlu, Hatice Resorlu, Şebnem Ataman, Ajda Bal, Mehmet Tuncay Duruöz, Okan Kucukakkas, Ozan Volkan Yurdakul, Meltem Alkan Melikoglu, Yıldıray Aydın, Figen Ayhan, Hatice Bodur, Mustafa Calis, Erhan Capkin, Gul Devrimsel, Kevser Gok, Sami Hizmetli, Ayhan Kamanlı, Yasar Keskin, Hilal Kocabas, Oznur Kutluk, Nesrin Şen, Omer Faruk Sendur, Murat Toprak, Sena Tolu, Tiraje Tuncer
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> PsA is a chronic musculoskeletal disease. The prevalence of axial involvement in PsA varies according to the duration of the disease. In early stage the incidence varies between 5% and 28%, but it increases up to 25-70% in later stages of the disease. In the literature, there is limited data on the differences in disease activity, functional status and quality of life of men and women with axial PsA. <h3>Objectives</h3> In this study, we aimed to evaluate the effect of gender difference on clinical findings, disease activity, functional status and quality of life in patients with axial involvement in Turkey. <h3>Methods</h3> Patients with PsA who met the CASPAR classification criteria were enrolled consequently in this cohort. Turkish League Against Rheumatism (TLAR)- Network was formed with the participation of 25 centers. The demographic variables, fatigue, diagnostic delay, the beginning of peripheral arthritis, enthesitis, dactylitis and spine involvement, inflammatory lumbar pain, patients' quality of life, BASFI, HAQ, HAQ-s,VAS pain, anxiety, depression and disease activity parameters (TJC, SJC, ESH, DAS28, BASDAI), were recorded. Student's t test and Chi-square test were used to compare variables in SPSS v.22 program. <h3>Results</h3> A total of 1130 patients (36.0% male, 64.0% female) with PsA included in this study. In this cohort, 169 male (46 ± 12.29) and 251 female (47.4 ± 12.11) had axial involvement. VAS pain (p &lt;0.001), fatigue (p &lt;0.001), ESR (p &lt;0.001), DAS28 (p &lt;0.001), BASDAI score (p &lt;0.001), PsAQoL (p &lt;0.001), HAQ score (p &lt;0.001), HAQ-S score (p &lt;0.001), anxiety (p &lt;0.001), depression (p &lt;0.020), FACIT (p &lt;0.001) and FIRST (p &lt;0.001) scores were statistically significantly worse in women than males with axial PsA (Table 1). However, SF-36 physical component score (p &lt;0.001), SF-36 mental component score (p &lt;0.001) and PASI score (p &lt;0.005) were statistically worse in male patients than in female patients with axial involvement. <h3>Conclusion</h3> This study shown that the burden of disease in axial PsA has a significantly different between genders. Female patients with PsA who have axial involvement have higher disease activity, physical disability, functional limitation and higher depression and anxiety risk than male patients. Therefore, we suggest that new strategies should be developed for more effective treatment of axial PsA in female patients. <h3>Disclosure of Interests</h3> Kemal Nas: None declared, Erkan Kilic: None declared, ibrahim tekeoğlu: None declared, Remzi Cevik: None declared, Betul Sargin: None declared, Sevtap Acer Kasman: None declared, Hakan Alkan: None declared, Nilay Sahin: None declared, Gizem Cengiz: None declared, Nihan Cuzdan: None declared, Ilknur Albayrak Gezer: None declared, Dilek Keskin: None declared, Cevriye Mülkoğlu: None declared, Hatice Resorlu: None declared, Şebnem Ataman: None declared, Ajda Bal: None declared, Mehmet Tuncay Duruöz Grant/research support from: Abvie, Speakers bureau: Novartis, AMGEN, Abdi İbrahim, İlko, Okan Kucukakkas: None declared, Ozan Volkan Yurdakul: None declared, Meltem Alkan Melikoglu: None declared, Yıldıray Aydın: None declared, Figen Ayhan: None declared, Hatice Bodur: None declared, Mustafa Calis: None declared, Erhan Capkin: None declared, Gul Devrimsel: None declared, Kevser Gok: None declared, SAMI HIZMETLI: None declared, Ayhan Kamanlı: None declared, Yasar Keskin: None declared, Hilal Kocabas: None declared, Oznur Kutluk: None declared, Nesrin Şen: None declared, Omer Faruk Sendur: None declared, Murat Toprak: None declared, Sena Tolu: None declared, Tiraje Tuncer: None declared