tbuckley/cabot-search huggingface dataset:
High- and ultra-high-field 3.0-T H-1- and 7.0-T P-31-MR spectroscopy prior to liver biopsy in patients with NAFLD allows non-invasive differentiation between fatty liver and NASH by profiling of hepatocellular lipid content and P-31 metabolites
Authors: S Traussnigg, E Halilbasic, B B Heinisch, J Stift, K Staufer, C H Kienbacher, M Gajdosik, L Valkovic, M Chmelik, L Kazemi-Shirazi, H Hofer, P E Steindl-Munda, A Ba-Ssalamah, F Wrba, P Ferenci, M Krebs, S Trattnig, M Krssak, M Trauner
Journal: Hepatology (2012)
Mutation burden and other molecular markers of prognosis in the QUASAR2 clinical trial of colorectal cancer treated with curative intent
Authors: E Domingo, C Camps, P J Kaisaki, M J Parsons, D Mouradov, M M Pentony, S Makino, M Palmieri, R L Ward, N J Hawkins
Journal: The Lancet. Gastroenterology & hepatology (2018)
Covid-19 and cardiovascular disease
Authors: Shivali Fulchand
Journal: BMJ (2020)

Guideline: Diagnosis and management of cardiovascular disease during the covid-19 pandemic Published by the European Society of Cardiology. This summary is based on the version published on 21 April 2020 ( https://www.escardio.org/Education/COVID-19-and-Cardiology/ESC-COVID-19-Guidance )
Long-Term Cognitive Impairment after Critical Illness
Authors: Gilles L Fraser, Richard R Riker, Douglas C Coursin
Journal: New England Journal of Medicine (2014)

BACKGROUND-Survivors of critical illness often have a prolonged and disabling form of cognitive impairment that remains inadequately characterized.METHODS-We enrolled adults with respiratory failure or shock in the medical or surgical intensive care unit (ICU), evaluated them for in-hospital delirium, and assessed global cognition and executive function 3 and 12 months after discharge with the use of the Repeatable Battery for the Assessment of Neuropsychological Status (population age-adjusted mean [±SD] score, 100±15, with lower values indicating worse global cognition) and the Trail Making Test, Part B (population age-, sex-, and education-adjusted mean score, 50±10, with lower scores indicating worse executive function).Associations of the duration of delirium and the use of sedative or analgesic agents with the outcomes were assessed with the use of linear regression, with adjustment for potential confounders.RESULTS-Of the 821 patients enrolled, 6% had cognitive impairment at baseline, and delirium developed in 74% during the hospital stay.At 3 months, 40% of the patients had global cognition scores that were 1.5 SD below the population means (similar to scores for patients with moderate traumatic brain injury), and 26% had scores 2 SD below the population means (similar to scores for patients with mild Alzheimer's disease).Deficits occurred in both older and younger patients and persisted, with 34% and 24% of all patients with assessments at 12 months that were similar to scores for patients with moderate traumatic brain injury and scores for patients with mild Alzheimer's disease, respectively.A longer duration of delirium was independently associated with worse global cognition at 3 and 12 months (P = 0.001 and P = 0.04, respectively) and worse executive function at 3 and 12 months (P = 0.004 and P = 0.007, respectively).Use of sedative or analgesic medications was not consistently associated with cognitive impairment at 3 and 12 months.CONCLUSIONS-Patients in medical and surgical ICUs are at high risk for long-term cognitive impairment.A longer duration of delirium in the hospital was associated with worse global cognition and executive function scores at 3 and 12 months.(Funded by the National Institutes of Health and others; BRAIN-ICU ClinicalTrials.govnumber, NCT00392795.)Survivors of critical illness frequently have a prolonged and poorly understood form of cognitive dysfunction, 1-4 which is characterized by new deficits (or exacerbations of preexisting mild deficits) in global cognition or executive function.This long-term cognitive impairment after critical illness may be a growing public health problem, given the large
Vitamin-D and COVID-19: do deficient risk a poorer outcome?
Authors: Fiona Mitchell
Journal: The Lancet Diabetes & Endocrinology (2020)

Despite difficulties in comparing data across nations, mortality from COVID-19 is clearly higher in some countries than in others. Many factors could have a role in this disparity, including differences in proportion of elderly people in a population, general health, accessibility and quality of healthcare, and socioeconomic status. One mostly overlooked factor that could influence outcome of COVID-19 is the relative vitamin D status of populations. Because people are advised to stay at home as much as possible, the government health agencies of Great Britain have recommended that people take vitamin D supplements through summer and autumn during this pandemic.
PREDICTION OF CAPSULE ENDOSCOPY RETENTION USING PATENCY CAPSULE COMPARED TO MAGNETIC RESONANCE ENTEROGRAPHY IN KNOWN CROHN´S DISEASE PATIENTS
Authors: G Blanco-Velasco, J Ramos-García, RA Zamarripa-Mottu, OM Solorzano-Pineda, MF Rojas-Illanes, B Rubio-Martínez, A Mayoral-Zavala, EV Rodríguez-Negrete, OV Hernández-Mondragón
Journal: Endoscopy (2020)

Aims Capsule endoscopy (CE) retention is as high as 13% in patients with Crohn’s disease (CD). Magnetic resonance enterography (MRE) and patency capsule (PC) are two useful tools for identifying strictures in small bowel (SB). The aim of this study is to compare the efficacy and safety of PC and RME for preventing CE retention in patients with CD.
Wet- versus dry-suction techniques for endoscopic ultrasound-guided fine-needle aspiration of solid lesions: a multicenter randomized controlled trial
Authors: Yun Wang, Rong-hua Wang, Zhen Ding, Shi-yun Tan, Qian Chen, Ya-qi Duan, Liang-ru Zhu, Ji-wang Cao, Jian Wang, Gan Shi, Xiao-li Wu, Jin-lin Wang, Yu-chong Zhao, Shou-jiang Tang, Bin Cheng
Journal: Endoscopy (2020)

Abstract Background The optimal sampling techniques for endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) remain unclear and have not been standardized. The aim of this study was to compare the wet-suction and dry-suction techniques for sampling solid lesions in the pancreas, mediastinum, and abdomen. Methods This was a multicenter, crossover, randomized controlled trial with randomized order of sampling techniques. The 296 consecutive patients underwent EUS-FNA with 22G needles and were randomized in a ratio of 1:1 into two separate groups that received the dry-suction and wet-suction techniques in a different order. The primary outcome was to compare the histological diagnostic accuracy of dry suction and wet suction for malignancy. The secondary outcomes were to compare the cytological diagnostic accuracy and specimen quality. Results Among the 269 patients with pancreatic (n = 161) and non-pancreatic (n = 108) lesions analyzed, the wet-suction technique had a significantly better histological diagnostic accuracy (84.9 % [95 % confidence interval (CI) 79.9 % – 89.0 %] vs. 73.2 % [95 %CI 67.1 % – 78.7 %]; P = 0.001), higher specimen adequacy (94.8 % vs. 78.8 %; P &lt; 0.001), and less blood contamination (P &lt; 0.001) than the dry-suction technique. In addition, sampling non-pancreatic lesions with two passes of wet suction provided a histological diagnostic accuracy of 91.6 %. Conclusions The wet-suction technique in EUS-FNA generates better histological diagnostic accuracy and specimen quality than the dry-suction technique. Furthermore, sampling non-pancreatic lesions with two passes of EUS-FNA with wet suction may provide a definitive histological diagnosis when rapid on-site evaluation is not routinely available.
Pili trianguli et canaliculi as a phenotypic subtype in patients with central centrifugal cicatricial alopecia: A scanning electron microscopy study
Authors: Erinolaoluwa F. Araoye, Jamael A.L. Thomas, LaToya Ann Roker, Ncoza C. Dlova, Crystal Aguh
Journal: Journal of the American Academy of Dermatology (2020)
FECAL MICROBIOTA TRANSPLANTATION FOR METABOLIC SYNDROME AND OBESITY: A SYTEMATIC REVIEW AND META-ANALYSIS BASED ON RANDOMIZED CLINICAL TRIALS
Authors: I Proença, IB Ribeiro, DTH de Moura, M Coronel, WM Bernardo, P Sakai, EGH de Moura
Journal: Endoscopy (2020)

Aims Obesity and metabolic syndrome are important health problems worldwide and they are related to development of atherosclerotic cardiovascular disease and non-alcoholic fatty liver disease (NAFLD) and consequently to their respective complications and morbidity/mortality. Gut microbiota has been related to many diseases including obesity and metabolic syndrome. Therapeutic approaches targeting dysbiosis and manipulation of gut microbiome have been recently developed such as prebiotics, probiotics, symbiotics, antibiotics and Fecal Microbiota Transplantation (FMT). This study aims to verify what is the role of FMT for obesity and metabolic syndrome.
Response to: ‘Antimalarial use and arrhythmias in COVID-19 and rheumatic patients: a matter of dose and inflammation?’ by Erre<i>et al</i>
Authors: Elizabeth R Graef, Jean W Liew, Alfred HJ Kim, Jeffrey A Sparks
Journal: Annals of the Rheumatic Diseases (2020)

Summary: A 2-year-old girl was found to have a pink pulsatile mass behind the right tympanic membrane on physical examination. We report the high-resolution CT and MR angiographic findings of persistent stapedial artery with hypoplasia of the A1 segment of the right anterior cerebral artery.
CAP-ASSISTED ENDOSCOPIC SEPTOTOMY OF ZENKER DIVERTICULUM (ZD): EARLY AND LONG-TERM OUTCOME
Authors: A Cappello, R Maselli, A Fugazza, S Carrara, L Lamonaca, M Spadaccini, D Paduano, PA Galtieri, C Romana, M Badalamenti, MD Leo, G Pellegatta, A Anderloni, A Repici
Journal: Endoscopy (2020)

Aims Minimally invasive flexible endoscopic septotomy (FES) techniques to manage ZD have been increasingly favored over the past 20 years even though long-term outcome data are scanty.
PROTECTIVE ROLE OF UNDERWATER ENDOSCOPIC MUCOSAL RESECTION AGAINST THE THERMAL INJURY. A RANDOMIZED CONTROL TRIAL AND CROSS-SECTIONAL ANALYSIS
Authors: JR Sánchez, MS Alonso, AS López, DC Ugarte, HI Uchima Koeklin, MP Ulquiza, JC Marín Gabriel, J Aranda, FR Pons, MA Alvarez González, L Hernández, RC Macian, J Santiago, O Patrón, A Herreros de Tejada, O Nogales, E Albéniz Albizu
Journal: Endoscopy (2020)

Aims Thermal injury is the corner stone of the delayed adverse events in EMR, however the strategy to downplay this fact has been scarce assessed. The role of immersion seems to be a suitable way to do it but this matter has not been tested so far.
Quality of Life With Pembrolizumab for Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: KEYNOTE-040
Authors: Kevin J Harrington, Denis Soulières, Christophe Le Tourneau, Jose Dinis, Lisa F Licitra, Myung-Ju Ahn, Ainara Soria, Jean-Pascal H Machiels, Nicolas Mach, Ranee Mehra, Barbara Burtness, Misoo C Ellison, Jonathan D Cheng, Diana Romana Chirovsky, Ramona F Swaby, Ezra E W Cohen
Journal: JNCI Journal of the National Cancer Institute (2020)

Head and neck squamous cell carcinoma (HNSCC) affects health-related quality of life (HRQoL); few treatments have demonstrated clinically meaningful HRQoL benefit. KEYNOTE-040 evaluated pembrolizumab vs standard of care (SOC) in patients with recurrent and/or metastatic HNSCC whose disease recurred or progressed after platinum-containing regimen.
THE OPTIMIZATION OF BRACHYTHERAPY BASED ON THE DATA OF BIOSPECTROFOTOMETRY
Authors: A Titaeva, S Tereschenko, L Lapaeva, E Velikanov, A Rubolovlev
Journal: Endoscopy (2020)

Aims Brachytherapy is a valuable element of the complex treatment of rectal cancer. But before brachytherapy it is necessary to have exact information about pathology focus, its size, healthy tissues and the area of the tumor and its boundaries.
PER-ORAL ENDOSCOPIC MYOTOMY IN THE MANAGEMENT OF ALLGROVE SYNDROME
Authors: I Iborra, A Aguilar, D Luna, J Serra, I Marin, N Caballero, J Colan, VM de Vega, E Domenech, H Uchima
Journal: Endoscopy (2020)

Background Few reports of POEM as treatment for achalasia in Allgrove syndrome has been reported.A 27 year old woman with Allgrove syndrome. Surgical and medical approaches failed thus endoscopic approach was decided. High-resolution esophageal manometry-impedance (HREM-I) showed type I achalasia and severe bolus retention. Endoscipic findings: POEM performed using a T type hybrid knife with no complications. HREM-I one month after the procedure showed complete relaxation of the inferior sphincter and improvement on the bolus retention. No dysphagia or reflux on the follow-up.
High resolution insight into hepatitis B virus infection and immunity in Africa to inform on intervention strategies
Authors: A Mcnaughton, J Lourenco, P A Bester, J Mokaya, S F Lumley, D Forde, T G Maponga, K R Katumba, D Goedhals, S Gupta, J Seeley, R Newton, P Ocama, P C Matthews
Journal: Journal of Hepatology (2019)
STRING-HEMOCLIPS FUSION: AN EFFECTIVE WAY FOR CLOSURE OF A LARGE MUCOSAL DEFECT AFTER EMR/ESD
Authors: J Espinel, E Pinedo
Journal: Endoscopy (2020)

Aims Large endoscopic submucosal resection (EMR) and dissection (ESD) remain technically challenging and are associated with high risks of severe adverse events (bleeding, delayed perforation); mainly if the patient is taking antithrombotic agents. Complete and strong closure of the post-EMR/ESD mucosal defect seems effective in preventing such events.
Cardiac dysfunction and thrombocytopenia-associated multiple organ failure inflammation phenotype in a severe paediatric case of COVID-19
Authors: Gwynne Latimer, Christiane Corriveau, Roberta L DeBiasi, Barbara Jantausch, Meghan Delaney, Cyril Jacquot, Michael Bell, Terry Dean
Journal: The Lancet Child & Adolescent Health (2020)
ASSOCIATION OF PATIENT FACTORS WITH FLAT AND PROTRUDED LESION REPORTING: OBSERVATIONS FROM THE EUROPEAN COLONOSCOPY QUALITY INVESTIGATION QUESTIONNAIRE
Authors: E Toth, P Amaro, A Agrawal, L Brink, W Fischbach, L Fuccio, M Hünger, U Kinnunen, A Koulaouzidis, A Ono, L Petruzziello, JF Riemann, B Amlani, C Spada
Journal: Endoscopy (2020)

Aims To assess the patient factors associated with flat and protruded lesion reporting, as defined by Paris classification.
ENDOSCOPIC SUBMUCOSAL DISSECTION USING SCISSOR-TYPE KNIFE (SB KNIFE JR) FOR LARGE BROAD-BASED OR STALKED COLONIC POLYPS: A MULTICENTRE CASE SERIES
Authors: A Dhillon, N Suzuki, R Rajaratnam, A Parra-Blanco, A Latchford, Y Shunsuke, A Ahmad, BP Saunders
Journal: Endoscopy (2020)

Aims Large, broad-based pedunculated (Ip) or sub-pedunculated (Isp) polyps can be technically difficult to resect with significant risk of intraprocedural and delayed bleeding. We report our experience in endoscopic submucosal dissection (ESD) using a scissor-type knife (SB-knife Junior, Sumius) for these lesions.
Remote video auditing in the endoscopy unit for evaluation of duodenoscope reprocessing in a tertiary care center
Authors: Kara L. Raphael, Ellen McNoble, Jessica Goldbeck, Megan Stiles, Larry S. Miller, Arvind J. Trindade
Journal: Endoscopy (2020)

Background A significant proportion of duodenoscope-transmitted infections have resulted from errors related to reprocessing. Remote video auditing (RVA) is a tool that can monitor reprocessing compliance but it has not been previously evaluated in a tertiary care setting. The aims of this study were to evaluate: 1) RVA feasibility in a tertiary care setting (defined as the ability to audit every step of duodenoscope reprocessing without delaying the next procedure due to unavailability of duodenoscopes); and 2) the use of RVA as a compliance monitoring tool. Methods This was a prospective study at a tertiary care center. A video camera with offsite monitoring was installed in March 2018. Auditors delivered a compliance score after each procedure. The duodenoscope was not used until it passed the audit. Feasibility and compliance data were collected from April 2018 to August 2019 after a 1-month run-in phase. Both per-step compliance and overall 100 % compliance rates were measured. Results Of 743 duodenoscope reprocessing procedures, 32 666 individual steps were audited and 99.9 % of the steps were fully viewable. The mean time per audit was 38.3 minutes, the mean duodenoscope turnover time was 76.1 minutes, and there were no delays to the next procedure due to unavailability of duodenoscopes. The per-step compliance rate was 99.5 % but the overall 100 % compliance rate was 90.3 %. Conclusions The use of RVA in duodenoscope reprocessing was feasible and promoted sustained high-level compliance in a tertiary care center.
LUMEN APPOSING METAL STENT HOT AXIOS IN ACUTE PANCREATITIS WALLED-OFF NECROSIS: COMPARISON STUDY BETWEEN 15 MM AND 20 MM STENT
Authors: C Nyeheck, B Jais, M Palazzo, F Maire, A Aubert, P Levy, V Rebours, D Lorenzo
Journal: Endoscopy (2020)

Aims The objective of this study is to compare the efficiency related to different sizes (15 mm vs 20 mm) of HOT AXIOS stents in the endoscopic treatment of AP collections.
USEFULLNESS OF ENDOSCOPIC ULTRASOUND (EUS) IN EARLY BILIARY PANCREATITIS WITHOUT CHOLESTASIS ON CONVENTIONAL IMAGING
Authors: S Bota, M Razpotnik, G Essler, J Weber-Eibel, M Peck-Radosavljevic
Journal: Endoscopy (2020)

Aims to assess the outcome of acute biliary pancreatitis (ABP) using EUS for deciding to perform an ERCP.
ENDOSCOPIC SUBMUCOSAL DISSECTION OF LOWER RECTAL LESION EXTENDING TO THE DENTATE LINE
Authors: CC Rebelo, N Nunes, MF de Lima, DB Moura, JR Pereira, VC Santos, AC Rego, N Paz, MA Duarte
Journal: Endoscopy (2020)

We present an endoscopic submucosal dissection (ESD) of a 50 mm sessile polyp, Paris Is, 2 cm from the anal margin.
“BASIC” CLASSIFICATION FOR COLORECTAL POLYPS: EVALUATION OF THE EFFICACY A QUICK TRAINING
Authors: R Hallit, J Jacques, E Coron, M Pioche, R Coriat, D Sautereau, S Chaussade
Journal: Endoscopy (2020)

Aims Advanced endoscopic imaging has revolutionized the characterization of polyps during colonoscopy.Many classifications (Kudo, NICE, Sano, WASP, CONNECT)were used based on the appearance of the pit pattern or vessels, the color or the macroscopic appearance of the polyps,the existence or not of a depression. A new BASIC classification covering all of these criterias was proposed and validated for the BLI(FUJIFILM). The main objective of this study is to evaluate the performance of senior non expert endoscopists after rapid training(< 24 hours) in the characterization of colorectal polyps.
ASSOCIATION OF PATIENT FACTORS WITH PEDUNCULATED AND NON-PEDUNCULATED LESION REPORTING: OBSERVATIONS FROM THE EUROPEAN COLONOSCOPY QUALITY INVESTIGATION QUESTIONNAIRE
Authors: A Koulaouzidis, P Amaro, A Agrawal, L Brink, W Fischbach, L Fuccio, M Hünger, U Kinnunen, A Ono, L Petruzziello, JF Riemann, E Toth, B Amlani, C Spada
Journal: Endoscopy (2020)

Aims To assess patient factors associated with pedunculated (Ip + Isp) and non-pedunculated (Is + flat) lesion reporting, as defined by Paris classification.
Health-Related Values and Preferences Regarding Meat Consumption
Authors: Claudia Valli, Montserrat Rabassa, Bradley C. Johnston, Ruben Kuijpers, Anna Prokop-Dorner, Joanna Zajac, Dawid Storman, Monika Storman, Malgorzata M. Bala, Ivan Solà, Dena Zeraatkar, Mi Ah Han, Robin W.M. Vernooij, Gordon H. Guyatt, Pablo Alonso-Coello
Journal: Annals of Internal Medicine (2019)

This systematic review evaluates evidence about people's preferences and values regarding meat consumption.
The Effect of Long-Term Intake of cis Unsaturated Fats on the Risk for Gallstone Disease in Men
Authors: Chung-Jyi Tsai, Michael F. Leitzmann, Walter C. Willett, Edward L. Giovannucci
Journal: Annals of Internal Medicine (2004)

A high intake of polyunsaturated and monounsaturated fats reduces cholesterol biosynthesis. In this long-term study of a large cohort of men, a diet high in unsaturated fats was associated with a r...
Treatment of Anxiety
Authors: George W. O'Neill
Journal: JAMA (1982)

<h3>To the Editor.—</h3> In a recent letter that reacted to the report by Hasday and Karch entitled "Benzodiazepine Prescribing in a Family Medicine Center" (1981;246:1321), Walter Strauser urged us to gather more data on the use of<i>pro re nata</i>prescriptions for benzodiazepines, since only 3.4% were prescribed in this manner (1982; 247:1936). We noted that the low rate is salutary; there is hazard in the<i>pro re nata</i>prescribing, as evidenced by the data gathered in substance abuse and pain treatment areas. The problem is understandable from principles of operant conditioning. Benzodiazepines are often reinforcing because they decrease aversive conditions, eg, fear and anxiety, and may also have positive reinforcing properties. They are especially powerful reinforcers because the effects are immediate. These drug effects may, therefore, reinforce intake behavior. Administering such drugs on a<i>pro re nata</i>schedule may tend to increase, not decrease, the frequency or intensity of
NOVEL ENDOSCOPIC MANAGEMENT OF A CHRONIC GASTRO-GASTRIC FISTULA USING A CARDIAC SEPTAL DEFECT OCCLUDER
Authors: DTH de Moura, AM da Ponte-Neto, IB Ribeiro, KE Hathorn, ES do Monte Junior, M Coronel, A Baptista, CC Thompson, EGH de Moura
Journal: Endoscopy (2020)

Closure of gastro-gastric(GG) fistulas after Roux-en-Y gastric bypass(RYGB) it’s a challenge. A 51-year-old woman, status-post RYGB in 2008, presented with a six-month history of weight regain and reflux. She had regained weight to 84kg when she was found to have a GG fistula. She underwent successful Cardiac septal defect occluders(CSDO) placement, and 3-months later, had lost 10kg with improvement in her reflux. Repeat evaluation confirmed successful closure without contrast leak. This is the first report of use of a CSDO for closure of a GG fistula. The use of CSDO was technically feasible and appeared to be effective and safe.
Correction to: Exosome-transmitted miR-128-3p increase chemosensitivity of oxaliplatin-resistant colorectal cancer
Authors: Tong Liu, Xin Zhang, Lutao Du, Yunshan Wang, Xiaoming Liu, Hui Tian, Lili Wang, Peilong Li, Yinghui Zhao, Weili Duan, Yujiao Xie, Zhaowei Sun, Chuanxin Wang
Journal: Molecular Cancer (2020)

An amendment to this paper has been published and can be accessed via the original article.
GEL-ASSISTED ESD FOR REMOVAL OF A RECTAL NON GRANULAR LATERALLY SPREADING TUMOR PSEUDO-DEPRESSED TYPE WITH SUSPICION OF SUPERFICIAL SUBMUCOSAL INVASIVE CANCER
Authors: S Ouazzani, AM Bucalau, P Gkolfakis, L Verset, JL Van Laethem, J Devière, A Lemmers
Journal: Endoscopy (2020)

A new gel lifting solution was used for the removal of a rectal non granular LST pseudo-depressed type, with suspicious pit pattern by ESD in a 64 y/o male. Briefly, 12ml of ORISETM gel (Boston Scientific) was injected with strong submucosal lifting, no per-procedural bleeding, no needed added per-procedural injection. An easy dissection of 15 min let us remove en-bloc a 30x25mm specimen revealing clear margins of a well-differentiated adenocarcinoma, without lymphovascular invasion or budding but submucosal invasion of 1038µm, giving a 1-2% risk of lymph node metastasis.