tbuckley/cabot-search huggingface dataset:
Unusual Electrocardiographic Findings in a Patient With a Postmyocardial Infarction
Authors: Qinghua Chang, Dianzhu Pan, Renguang Liu
Journal: JAMA Internal Medicine (2020)

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Role of interaction between B cells and epithelial cells in pSS
Authors: Sarah Pringle, Gwenny M Verstappen, Hendrika Bootsma, Frans G M Kroese
Journal: Annals of the Rheumatic Diseases (2020)

Correspondencewhether cultured SGECs are representative of in situ epithelial cells remains to be shown.Although providing a platform for drug screening from which to further expand on and certainly representing an important contribution to the field, the applicability of two-dimensional epithelial cultures to in situ SG architecture remains to be validated.Three-dimensional approaches using SG organoids may represent a step towards true reflection of reality, and have been shown to provide valuable information about epithelial cell dynamics in pSS. 6While acknowledging the novel and extensive work presented by Rivière et al, we look forward to seeing how the more intricate interactions between B cells and the epithelium can be teased apart, including those of LEL development.
TCT CONNECT-291 Long-Term Outcome Following Percutaneous Intervention of Intrastent Coronary Occlusion
Authors: Satoru Mitomo, Sunao Nakamura, Sampath Athukorala, Gurbir Bhatia, Richard Watkin, George Pulikal, Sandeep Basavarajaiah
Journal: Journal of the American College of Cardiology (2020)
Vaccination Coverage by Age 24 Months Among Children Born in 2016 and 2017 — National Immunization Survey-Child, United States, 2017–2019
Authors: Holly A. Hill, David Yankey, Laurie D. Elam-Evans, James A. Singleton, S. Cassandra Pingali, Tammy A. Santibanez
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

Immunization has been described as a "global health and development success story," and worldwide is estimated to prevent 2-3 million deaths annually.* In the United States, the Advisory Committee on Immunization Practices (ACIP) currently recommends vaccination against 14 potentially serious illnesses by the time a child reaches age 24 months (1). CDC monitors coverage with ACIP-recommended vaccines through the National Immunization Survey-Child (NIS-Child); data from the survey were used to estimate vaccination coverage at the national, regional, state, territorial, and selected local area levels† among children born in 2016 and 2017. National coverage by age 24 months was ≥90% for ≥3 doses of poliovirus vaccine, ≥3 doses of hepatitis B vaccine (HepB), and ≥1 dose of varicella vaccine (VAR); national coverage was ≥90% for ≥1 dose of measles, mumps, and rubella vaccine (MMR), although MMR coverage was <90% in 14 states. Coverage with ≥2 doses of influenza vaccine was higher for children born during 2016-2017 (58.1%) than for those born during 2014-2015 (53.8%) but was the lowest among all vaccines studied. Only 1.2% of children had received no vaccinations by age 24 months. Vaccination coverage among children enrolled in Medicaid or with no health insurance was lower than that among children who were privately insured. The prevalence of being completely unvaccinated was highest among uninsured children (4.1%), lower among those enrolled in Medicaid (1.3%), and lowest among those with private insurance (0.8%). The largest disparities on the basis of health insurance status occurred for ≥2 doses of influenza vaccine and for completion of the rotavirus vaccination series. Considering the disruptions to health care provider operations caused by the coronavirus disease 2019 (COVID-19) pandemic, extra effort will be required to achieve and maintain high levels of coverage with routine childhood vaccinations. Providers, health care entities, and public health authorities can communicate with families about how children can be vaccinated safely during the pandemic, remind parents of vaccinations that are due for their children, and provide all recommended vaccinations to children during clinic visits. This will be especially important for 2020-21 seasonal influenza vaccination to mitigate the effect of two potentially serious respiratory viruses circulating in the community simultaneously.
TCT CONNECT-165 Orbital Atherectomy for Treating De Novo, Severely Calcified Coronary Lesions: A Tertiary Center Experience
Authors: Juan Vinardell, Carlos Podesta, Nafees Mohammed, Todd Heimowitz, Christian Koelbl, Helen Parise, Ajay Kirtane, Nirat Beohar
Journal: Journal of the American College of Cardiology (2020)
TCT CONNECT-340 Hemolysis After Transcatheter Mitral Valve Replacement: Incidence, Patient Characteristics, and Clinical Outcomes
Authors: Bassim El-Sabawi, Mayra Guerrero, Mackram Eleid, Vuyisile Nkomo, Sorin Pislaru, Chet Rihal
Journal: Journal of the American College of Cardiology (2020)
Virology, transmission, and pathogenesis of SARS-CoV-2
Authors: Muge Cevik, Krutika Kuppalli, Jason Kindrachuk, Malik Peiris
Journal: BMJ (2020)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Virology, transmission, and pathogenesis of SARS-CoV-2 Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
TCT CONNECT-27 Impact of Prior Coronary Artery Bypass in Elderly Patients Presenting With Acute Myocardial Infarction
Authors: Alejandro Lemor, Gabriel Hernandez, Sati Patel, Mir Basir, Pedro Villablanca, Khaldoon Alaswad, William O'Neill
Journal: Journal of the American College of Cardiology (2020)
Anticancer drugs are not well tolerated in all older patients with cancer
Authors: Hans Wildiers, Nienke A de Glas
Journal: The Lancet Healthy Longevity (2020)

Studies on new anticancer drugs often inappropriately conclude that these treatments are well tolerated and feasible in the older population with cancer, despite the drug being investigated in only a selection of healthy older patients who are not representative of the true older population. In this Personal View we outline examples of reports that provide misleading information to clinicians, mostly because the tolerance and efficacy were not assessed according to frailty status and only a few people who are frail were included. We also provide solutions on how to inform clinicians, patients, and health authorities more clearly about the benefits and disadvantages of new and upcoming anticancer drugs for older people with cancer.
Early detection and tracking of bulbar changes in ALS via frequent and remote speech analysis
Authors: Gabriela M. Stegmann, Shira Hahn, Julie Liss, Jeremy Shefner, Seward Rutkove, Kerisa Shelton, Cayla Jessica Duncan, Visar Berisha
Journal: npj Digital Medicine (2020)

Abstract Bulbar deterioration in amyotrophic lateral sclerosis (ALS) is a devastating characteristic that impairs patients’ ability to communicate, and is linked to shorter survival. The existing clinical instruments for assessing bulbar function lack sensitivity to early changes. In this paper, using a cohort of N = 65 ALS patients who provided regular speech samples for 3–9 months, we demonstrated that it is possible to remotely detect early speech changes and track speech progression in ALS via automated algorithmic assessment of speech collected digitally.
Galectin-9-based immune risk score model helps to predict relapse in stage I–III small cell lung cancer
Authors: Peixin Chen, Liping Zhang, Wei Zhang, Chenglong Sun, Chunyan Wu, Yayi He, Caicun Zhou
Journal: Journal for ImmunoTherapy of Cancer (2020)

For small cell lung cancer (SCLC) therapy, immunotherapy might have unique advantages to some extent. Galectin-9 (Gal-9) plays an important role in antitumor immunity, while little is known of its function in SCLC.By mean of immunohistochemistry (IHC), we tested the expression level of Gal-9 and other immune markers on both tumor cells and tumor-infiltrating lymphocytes (TILs) in 102 surgical-resected early stage SCLC clinical samples. On the basis of statistical analysis and machine learning results, the Gal-9-based immune risk score model was constructed and its predictive performance was evaluated. Then, we thoroughly explored the effects of Gal-9 and immune risk score on SCLC immune microenvironment and immune infiltration in different cohorts and platforms.In the SCLC cohort for IHC, the expression level of Gal-9 on TILs was statistically correlated with the levels of program death-1 (p=0.001), program death-ligand 1 (PD-L1) (p<0.001), CD3 (p<0.001), CD4 (p<0.001), CD8 (p<0.001), and FOXP3 (p=0.047). High Gal-9 protein expression on TILs indicated better recurrence-free survival (30.4 months, 95% CI: 23.7-37.1 vs 39.4 months, 95% CI: 31.6-47.3, p=0.009). The immune risk score model which consisted of Gal-9 on TILs, CD4, and PD-L1 on TILs was established and validated so as to differentiate high-risk or low-risk patients with SCLC. The prognostic predictive performance of immune risk score model was better than single immune biomarker (area under the curve 0.671 vs 0.621-0.644). High Gal-9-related enrichment pathways in SCLC were enriched in immune system diseases and rheumatic disease. Furthermore, we found that patients with SCLC with low immune risk score presented higher fractions of activated memory CD4 T cells than patients with high immune risk score (p=0.048).Gal-9 is markedly related to tumor-immune microenvironment and immune infiltration in SCLC. This study emphasized the predictive value and promising clinical applications of Gal-9 in stage I-III SCLC.
TCT CONNECT-173 Prognostic Impact of SYNTAX II Score in Patients With Cardiogenic Shock Complicating ST-Elevation Myocardial Infarction: Analysis of an 10-Year All-Comers Registry
Authors: Maria Juskova, Pablo Tasende Rey, Belen Alvarez Alvarez, Eva González Babarro, Jose Maria Garcia Acuna, Pedro Rigueiro, Rosa Maria Agra Bermejo, Ramiro Trillo, Jose Ramon González-Juanatey, Belen Cid Alvarez
Journal: Journal of the American College of Cardiology (2020)
A Small-Molecule Approach to Restore a Slow-Oxidative Phenotype and Defective CaMKIIβ Signaling in Limb Girdle Muscular Dystrophy
Authors: Jian Liu, Jesus Campagna, Varghese John, Robert Damoiseaux, Ekaterina Mokhonova, Diana Becerra, Huan Meng, Elizabeth M. McNally, April D. Pyle, Irina Kramerova, Melissa J. Spencer
Journal: Cell Reports Medicine (2020)

Mutations in CAPN3 cause limb girdle muscular dystrophy R1 (LGMDR1, formerly LGMD2A) and lead to progressive and debilitating muscle wasting. Calpain 3 deficiency is associated with impaired CaMKIIβ signaling and blunted transcriptional programs that encode the slow-oxidative muscle phenotype. We conducted a high-throughput screen on a target of CaMKII (Myl2) to identify compounds to override this signaling defect; 4 were tested in vivo in the Capn3 knockout (C3KO) model of LGMDR1. The leading compound, AMBMP, showed good exposure and was able to reverse the LGMDR1 phenotype in vivo, including improved oxidative properties, increased slow fiber size, and enhanced exercise performance. AMBMP also activated CaMKIIβ signaling, but it did not alter other pathways known to be associated with muscle growth. Thus, AMBMP treatment activates CaMKII and metabolically reprograms skeletal muscle toward a slow muscle phenotype. These proof-of-concept studies lend support for an approach to the development of therapeutics for LGMDR1.
TCT CONNECT-44 Influence of Obstructive Sleep Apnea on Outcomes in Patients With ST-Segment Elevation Myocardial Infarction (STEMI): The Role of the Coronary Collateral Circulation
Authors: Usaid Allahwala, Peter Cistulli, Jonathan Ciofani, Hasthi Dissanayake, Michael Ward, James Weaver, Ravinay Bhindi
Journal: Journal of the American College of Cardiology (2020)
Cancer therapy shapes the fitness landscape of clonal hematopoiesis
Authors: Kelly L. Bolton, Ryan N. Ptashkin, Teng Gao, Lior Braunstein, Sean M. Devlin, Daniel Kelly, Minal Patel, Antonin Berthon, Aijazuddin Syed, Mariko Yabe, Catherine C. Coombs, Nicole M. Caltabellotta, Mike Walsh, Kenneth Offit, Zsofia Stadler, Diana Mandelker, Jessica Schulman, Akshar Patel, John Philip, Elsa Bernard, Gunes Gundem, Juan E. Arango Ossa, Max Levine, Juan S. Medina Martinez, Noushin Farnoud, Dominik Glodzik, Sonya Li, Mark E. Robson, Choonsik Lee, Paul D. P. Pharoah, Konrad H. Stopsack, Barbara Spitzer, Simon Mantha, James Fagin, Laura Boucai, Christopher J. Gibson, Benjamin L. Ebert, Andrew L. Young, Todd Druley, Koichi Takahashi, Nancy Gillis, Markus Ball, Eric Padron, David M. Hyman, Jose Baselga, Larry Norton, Stuart Gardos, Virginia M. Klimek, Howard Scher, Dean Bajorin, Eder Paraiso, Ryma Benayed, Maria E. Arcila, Marc Ladanyi, David B. Solit, Michael F. Berger, Martin Tallman, Montserrat Garcia-Closas, Nilanjan Chatterjee, Luis A. Diaz, Ross L. Levine, Lindsay M. Morton, Ahmet Zehir, Elli Papaemmanuil
Journal: Nature Genetics (2020)
TCT CONNECT-20 Racial/Ethnic Disparities in Outcomes in Very Elderly Patients Undergoing Revascularization for Acute Myocardial Infarction
Authors: Derek Phan, Ara Rostomian, Ming-Sum Lee, Naing Moore, Prakash Mansukhani, Vicken Aharonian, Somjot Brar, Ray Zadegan
Journal: Journal of the American College of Cardiology (2020)
Xenograft and cell culture models of Sézary syndrome reveal cell of origin diversity and subclonal heterogeneity
Authors: Sandrine Poglio, Martina Prochazkova-Carlotti, Floriane Cherrier, Audrey Gros, Elodie Laharanne, Anne Pham-Ledard, Marie Beylot-Barry, Jean-Philippe Merlio
Journal: Leukemia (2020)

Abstract Sézary Syndrome (SS) is a rare aggressive epidermotropic cutaneous T-cell lymphoma (CTCL) defined by erythroderma, pruritis, and a circulating atypical CD4 + T-cell clonal population. The diversity of Sézary cell (SC) phenotype and genotype may reflect either plasticity or heterogeneity, which was difficult to evaluate dynamically until the achievement of long-term SC expansion. Therefore, we developed six defined culture conditions allowing for the expansion of SC defined by their phenotype and monoclonality in four of seven SS cases. Engraftment of SC through the intrafemoral route into immunodeficient NOD.Cg-Prkdc(scid)Il2rg( tm1Wjll )/SzJ (NSG) mice was achieved in 2 of 14 SS cases. Secondary xenograft by percutaneous injection mimicked most of the features of SS with dermal infiltration, epidermotropism, and blood spreading. These models also allowed assessing the intra-individual heterogeneity of patient SC. Subclones sharing the same TCR gene rearrangement evolved independently according to culture conditions and/or after xenografting. This clonal selection was associated with some immunophenotypic plasticity and limited genomic evolution both in vitro and in vivo. The long-term amplification of SC allowed us to develop eight new SC lines derived from four different patients. These lines represent the cell of origin diversity of SC and provide new tools to evaluate their functional hallmarks and response to therapy.
UEFA expert group statement on nutrition in elite football. Current evidence to inform practical recommendations and guide future research
Authors: James Collins, Ronald John Maughan, Michael Gleeson, Johann Bilsborough, Asker Jeukendrup, James P Morton, S M Phillips, Lawrence Armstrong, Louise M Burke, Graeme L Close, Rob Duffield, Enette Larson-Meyer, Julien Louis, Daniel Medina, Flavia Meyer, Ian Rollo, Jorunn Sundgot-Borgen, Benjamin T Wall, Beatriz Boullosa, Gregory Dupont, Antonia Lizarraga, Peter Res, Mario Bizzini, Carlo Castagna, Charlotte M Cowie, Michel D"Hooghe, Hans Geyer, Tim Meyer, Niki Papadimitriou, Marc Vouillamoz, Alan McCall
Journal: British Journal of Sports Medicine (2020)

Football is a global game which is constantly evolving, showing substantial increases in physical and technical demands. Nutrition plays a valuable integrated role in optimising performance of elite players during training and match-play, and maintaining their overall health throughout the season. An evidence-based approach to nutrition emphasising, a 'food first' philosophy (ie, food over supplements), is fundamental to ensure effective player support. This requires relevant scientific evidence to be applied according to the constraints of what is practical and feasible in the football setting. The science underpinning sports nutrition is evolving fast, and practitioners must be alert to new developments. In response to these developments, the Union of European Football Associations (UEFA) has gathered experts in applied sports nutrition research as well as practitioners working with elite football clubs and national associations/federations to issue an expert statement on a range of topics relevant to elite football nutrition: (1) match day nutrition, (2) training day nutrition, (3) body composition, (4) stressful environments and travel, (5) cultural diversity and dietary considerations, (6) dietary supplements, (7) rehabilitation, (8) referees and (9) junior high-level players. The expert group provide a narrative synthesis of the scientific background relating to these topics based on their knowledge and experience of the scientific research literature, as well as practical experience of applying knowledge within an elite sports setting. Our intention is to provide readers with content to help drive their own practical recommendations. In addition, to provide guidance to applied researchers where to focus future efforts.
Abstract 15772: Effectiveness of Mobile Health Technology Interventions on Patients With Heart Failure: Systematic Review and Meta-Analysis
Authors: Spyros Kitsiou, Haleh Vatani, Guy Paré, Ben Gerber, Susan W Buchholz, Mayank M Kansal, Ruth M Masterson Creber
Journal: Circulation (2019)

Introduction: Heart failure (HF) is associated with high mortality and hospitalization rates. Recent advances in mobile health (mHealth) technologies such as mobile apps and wearable sensor devices...
Gender inequalities in health and wellbeing across the first two decades of life: an analysis of 40 low-income and middle-income countries in the Asia-Pacific region
Authors: Elissa Kennedy, Gerda Binder, Karen Humphries-Waa, Tom Tidhar, Karly Cini, Liz Comrie-Thomson, Cathy Vaughan, Kate Francis, Nick Scott, Nisaa Wulan, George Patton, Peter Azzopardi
Journal: The Lancet Global Health (2020)

By adulthood, gender inequalities in health and wellbeing are apparent. Yet, the timing and nature of gender inequalities during childhood and adolescence are less clear. We describe the emergence of gender inequalities in health and wellbeing across the first two decades of life.We focused on the 40 low-income and middle-income countries in Asia and the Pacific. A measurement framework was developed around four key domains of wellbeing across the first two decades: health, education and transition to employment, protection, and a safe environment. Specific measurement constructs were then defined by considering gender indicator frameworks, the Sustainable Development Goals, indicator frameworks for child and adolescent health and wellbeing, and key stakeholder input. Available data were then mapped to define 87 indicators, subsequently populated using databases (UN agencies and the Global Burden of Diseases, Injuries, and Risk Factors Study) and nationally representative surveys. Where possible, estimates in girls were compared with boys to report relative risks.Although son preference is evident in some settings-as shown by higher than expected male-to-female sex ratios at birth in India, Vietnam, and China (all >1·10 compared with an expected ratio of 1·05) and excess mortality of girl children in some South Asian and Pacific nations-it is during early adolescence where marked gender inequalities consistently emerged. Adolescent girls face considerable disadvantage in relation to sexual and reproductive health (notably in South Asia and the Pacific), with high rates of child marriage (≥30% of women aged 20-24 years married before 18 years in Bangladesh, Nepal, and Afghanistan), fertility (≥65 livebirths per 1000 girls in Nauru, Laos, Afghanistan, Nepal, Marshall Islands, Bangladesh, Vanuatu, and Papua New Guinea), and intimate partner violence (>20% in Timor Leste, Afghanistan, Pakistan, and Myanmar). Despite educational parity in many countries, females aged 15-24 years were less likely than males to be in education, employment, or training in 17 of 19 countries for which data were available. Compared with girls, adolescent boys experienced excess all-cause mortality and substantially higher mortality due to unintentional injury, interpersonal violence, alcohol and other drugs, and suicide, and higher prevalence of harmful drinking and tobacco smoking.These findings call for a focus on gender policy and programming in later childhood and early adolescence before gender inequalities become embedded.UNICEF.