tbuckley/cabot-search huggingface dataset:
Evaluation of Oxygen Saturation Index Compared With Oxygenation Index in Neonates With Hypoxemic Respiratory Failure
Authors: Hemananda K. Muniraman, Ashley Y. Song, Rangasamy Ramanathan, Kathryn L. Fletcher, Rutuja Kibe, Li Ding, Ashwini Lakshmanan, Manoj Biniwale
Journal: JAMA Network Open (2019)

Oxygenation index (OI), an invasive measurement, is routinely used as a marker of severity of hypoxemic respiratory failure in neonates. Oxygen saturation index (OSI) is a noninvasive measurement and has been shown to be a reliable surrogate marker of OI in children and adults with respiratory failure.To evaluate the correlation of OI with OSI and to derive and validate predictive OI from noninvasive OSI measurements for clinically relevant OI values.For this retrospective cohort study, 220 neonates requiring invasive mechanical ventilation for hypoxic respiratory failure during the first 3 days of admission were recruited from a level III neonatal intensive care unit during a 6-year period, from January 1, 2012, to December 31, 2017. Data were analyzed from January 2017 to December 2017.The primary outcome was correlation of OI with OSI, analyzed using Pearson correlation coefficient. The secondary outcome was derivation and validation of OI from OSI. The data were split into derivative samples, from which a predictive equation for OI was derived using generalized linear model, and a validation sample was used to assess the predictive ability of the derived OI. Bland-Altman plot was used to assess agreement between derived OI and measured OI.A total of 1442 paired OI and OSI measurements from 220 infants (190 preterm and 30 term; median [interquartile range] gestational age, 29 [26-33] weeks; mean [SD] birth weight, 1602 [1092] g) were recorded during the study. The median (interquartile range) number of samples was 5 (3-9) per patient. Overall, OI and OSI showed strong correlation (r = 0.89). The correlation was stronger in preterm infants (<28 weeks, r = 0.93; 28-33 weeks, r = 0.93) and within an oxygen saturation range of 85% to 95% (r = 0.94). The predictive derivative equation showed a strong linear association and good agreement in both derivation and validation data sets, with strong accuracy measures of derived OI for OI cutoffs of 5, 10, 15, 20, and 25.A strong correlation of OI with OSI was found. Derived OI from OSI was in good agreement and strongly predictive of clinically relevant OI cutoffs from 5 to 25. Oxygenation index derived from noninvasive sources may be useful to reliably assess severity of respiratory failure and response to therapy on a continuous basis.
GP who ran “report writing factory” escapes jail term for contempt of court
Authors: Clare Dyer
Journal: BMJ (2019)

A GP who ran a “report writing factory” and signed a false witness report in a road traffic case has escaped a jail term after being found guilty of contempt of court.

The Court of Appeal has ruled that Asef Zafar, who exaggerated a taxi driver’s injuries in an expert report, received an unduly lenient sentence last October when a High Court judge, Mr Justice Garnham, gave him a six month suspended term for contempt of court.1

The three appeal court judges said that his sentence should have been significantly longer …
Abstract 16593: Role of miR-467 Pathway in Regulation of Macrophage, Functions, Inflammation, and Insulin Resistance
Authors: Jasmine Gajeton, Irene Krukovets, Revanth Yendamuri, Lidiya Sul, Olga Stenina-Adognravi
Journal: Circulation (2017)

Chronic inflammation and insulin resistance (IR) lead to cardiovascular events. Diet-induced obesity promotes inflammation and IR: hypertrophic adipose tissue has reduced angiogenic response leadin...
A five‐year review of quality of reporting of research using clinician surveys in high‐ranked dermatology journals
Authors: A.G.H. Wernham, J.M. Kilgour, J.R. Ingram, R.N. Matin
Journal: British Journal of Dermatology (2019)

h a m , A, Kilgo ur, J, In g r a m , J. R. a n d M a ti n, R. N. 2 0 1 9.
Helen Salisbury: Should I persuade patients to have mammograms?
Authors: Helen Salisbury
Journal: BMJ (2019)

Our practice has recently been invited by the local clinical commissioning group to take part in a quality improvement scheme aimed at increasing the uptake of cancer screening. We are offered support from Cancer Research UK to make an action plan to improve rates of bowel, cervical, and breast cancer screening. We’re incentivised with payments for engaging in the process and for any increase in the proportion of our patients screened.

I wish I could say that my conversations about cancer screening all adhere to guidelines about how to share decisions with patients.1 In reality, most …
Abstract 13539: Functional Evaluation in Aortic Stenosis: Determinant of Exercise Capacity
Authors: FrancescoBandera, GretaGenerati, MartaPellegrino, ValentinaLabate, FrancescoCarbone, EleonoraAlfonzetti, MarcoGuazzi
Journal: Circulation (2015)

Background: Aortic stenosis (AS) is clinically characterized by dyspnea and intolerance to exercise. Clinical interpretation of such symptoms is often difficult due to the advanced age of AS patients. We aimed at identifying cardiac determinants of exercise intolerance in AS (Aortic Vmax >3 m/s). Methods and results: We performed cardiopulmonary exercise test (CPET) simultaneously combined with exercise echocardiography in 43 patients with AS referred for functional assessment. Severe AS were evaluated because of symptoms not certainly related to valvular disease. Patients underwent a symptoms-limited maximal exercise, considering the 75% of predicted VO2 consumption as a marker of preserved functional capacity. Twenty-three patients had preserved functional capacity (group A), showing higher work, maximal VO2, O2 pulse and better VE/VCO2 and heart rate recovery. No differences were found in terms of rest systolic function and AS severity, while group A had higher peak heart rate (HR), higher peak cardiac...
Multifunctional Biomedical Adhesives
Authors: Rattapol Pinnaratip, Mohammad Saleh Akram Bhuiyan, Kaylee Meyers, Rupak M. Rajachar, Bruce P. Lee
Journal: Advanced Healthcare Materials (2019)

Currently available biomedical adhesives are mainly engineered to have one function (i.e., providing mechanical support for the repaired tissue). To improve the performance of existing bioadhesives and broaden their applications in medicine, numerous multifunctional bioadhesives are reported in the literature. These adhesives can be categorized as passive or active by design. Passive multifunctional bioadhesives contain inherent compositions and structural designs that can carry out additional functions without added external influences. These adhesives exhibit new functionalities such as antimicrobial properties, self-healing abilities, the ability to promote cellular ingrowth, and the ability to be reshaped. Conversely, active multifunctional bioadhesives respond to environmental changes (e.g., pH, temperature, electricity, light, and biomolecule concentration), which initiate a change in the adhesive to release encapsulated drugs or to activate or deactivate the bioadhesive for interfacial binding. This review article highlights recent advances in multifunctional bioadhesives.
Long-Term Risk of Infective Endocarditis After Transcatheter Aortic Valve Replacement
Authors: Jawad H. Butt, Nikolaj Ihlemann, Ole De Backer, Lars Søndergaard, Eva Havers-Borgersen, Gunnar H. Gislason, Christian Torp-Pedersen, Lars Køber, Emil L. Fosbøl
Journal: Journal of the American College of Cardiology (2019)
Abstract 17986: Is There Really an “Obesity Paradox” in Heart Failure? An Analysis of PARADIGM-HF
Authors: Ulrik M Mogensen, Pardeep Jhund, Lars Køber, Akshay Desai, Jean Rouleau, Scott Solomon, Karl Swedberg, Michael Zile, Martin Lefkowitz, Victor Shi, Milton Packer, John J McMurray
Journal: Circulation (2016)

Introduction: Previous studies have suggested an “obesity paradox” in heart failure and reduced ejection fraction (HF-REF) whereby patients with a high body mass index (BMI) had a better survival t...
First women to study medicine in the UK are honoured
Authors: Bryan Christie
Journal: BMJ (2019)

A group of women who, in 1869, were the first to study medicine at a UK university are to be awarded posthumous degrees in recognition of their role in widening access to education.

The women, who became known as the Edinburgh Seven, were never allowed to graduate. Such was the hostility towards them that several hundred male students pelted them with mud on one occasion as they arrived for an anatomy exam.

The women were led by Sophia Jex-Blake …
Abstract 19832: De Novo Mutations in Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Are Rare and Associated With Large Deletions
Authors: Freyja H van Lint, Crystal Tichnell, Brittney Murray, Nuria Amat, Sven Dittmann, Birgit Stallmeyer, Hugh Calkins, Jan D Jongbloed, Jasper J van der Smagt, Ronald H Lekanne Deprez, Eric Schulze-Bahr, Dennis Dooijes, Paul A van der Zwaag, Daniel P Judge, J. Peter van Tintelen, Cynthia A James
Journal: Circulation (2017)

Introduction: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is associated with mutations in genes encoding the cardiac desmosome. Inheritance of ARVC is autosomal dominant, however patients frequently have no family history, raising the question of whether a mutation is de novo (first occurring in the patient) or has been inherited. Prevalence and characteristics of de novo mutations in ARVC have never been described. Hypothesis: We predicted de novo desmosomal mutations are rare. Methods: In a multinational ARVC registry we identified 172 index patients who 1) met 2010 Task Force Criteria, 2) had one or more pathogenic/likely pathogenic desmosomal variants, and 3) whose family had undertaken genetic cascade screening. Variants were classified based on American College of Medical Genetics and Genomics guidelines. Inheritance of variants was assessed by pedigree analysis. Haplotyping of microsatellite markers was conducted for 5 common PKP2 variants (c.2386T>C, c.1848C>A, c.397C>T, c.235C>T, c.214...
Objective evaluation of the response of infantile haemangiomas to propranolol treatment using a three‐dimensional imaging system
Authors: R. Moro, A. Fabiano, F. Mangeri, A. Di Buduo, A. Manerba, M. Rossini, P.G. Calzavara‐Pinton, G. Gualdi
Journal: British Journal of Dermatology (2019)
Would You Refer This Patient With Cancer to a Palliative Care Specialist?
Authors: Eileen E. Reynolds, Mary K. Buss, Benjamin L. Schlechter, Anjala Tess
Journal: Annals of Internal Medicine (2019)

In 2016, the American Society of Clinical Oncology published a guideline recommending that all patients with advanced cancer be referred to palliative care providers. This recommendation was based on a series of trials showing that palliative care, when added to standard oncology treatment, improves outcomes, including quality of life. Here, 2 oncologists, 1 of whom is also a palliative care specialist, debate the guideline and discuss how best to care for a 71-year-old woman with metastatic neuroendocrine carcinoma who has a short life expectancy but feels well and has no symptoms related to her cancer or chemotherapy.
Efficient Gene Transduction and Reprogramming of Hematopoietic Cells Including T-Cells By Using a Non-Integrating Measles Virus Vector
Authors: Jiyuan Liao, Yasushi Soda, Ai Sugawara, Yoshie Miura, Takafumi Hiramoto, Maino Tahara, Yuto Takishima, Lisa Hirose, Yasuki Hijikata, Shohei Miyamoto, Makoto Takeda, Kenzaburo Tani
Journal: Blood (2018)
Poor understanding of modern slavery in the healthcare system
Authors: Patrick J Saunders, Megan Harris
Journal: BMJ (2019)

Such and colleagues are right to describe modern slavery as a public health problem as well as a law enforcement issue.1 They also emphasise the missed opportunity for healthcare professionals to protect victims because of inadequate training in, and awareness of, the signs, consequences, and effective responses. This is especially true for sexual exploitation.

Data from the UK National Crime Agency show that sexual exploitation was the second most common type …
Studies Further Support Transmissibility of Alzheimer Disease–Associated Proteins
Authors: Tracy Hampton
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply
Authors: Raj Vuppalanchi, Naga Chalasani
Journal: Hepatology (2019)

Potential conflict of interest: Nothing to report. We appreciate the interest and the thoughtful response by Gioia et al. on our recent observations about the liver stiffness measurement in patients with noncirrhotic portal hypertension (NCPH). The causes of NCPH are myriad and can be prehepatic, hepatic, or posthepatic. Previous studies have reported that hepatic causes, such as nodular regenerative hyperplasia (NRH), can have variable liver stiffness measurement (LSM) based on severity and concomitant fibrosis.1 In addition to observing similar variability in LSM in patients with NRH, we also found a relationship between hepatic venous pressure gradient and LSM. However, our assumption that LSM would be normal in patients with portal vein thrombosis (PVT), a prehepatic cause of NCPH, was not observed in all. In our case series, 12 of the 13 patients with PVT underwent evaluation with a liver biopsy, and no significant findings other than minimal fibrosis and some sinusoidal congestion were reported.2 Despite that, one third had abnormal LSM of >10 kPa, indicative of compensated advanced chronic liver disease.2 We also observed that free hepatic vein pressure (FHVP) was increased in PVT patients with abnormal LSM.2 We speculate that the increased FHVP may be possibly related to hyperdynamic circulation attributed to development of collateral vessels and altered hepatic artery blood flow given that it is inversely related to portal vein flow. Moreover, compression by choledochal or periportal varices of the extrahepatic biliary tree from chronic PVT resulting in portal/biliary cholangiopathy may be associated with increased biliary pressure.4 As pointed out by Gioia et al., patients with PVT have associated subtle histological features, such as phleboclerosis, NRH, sinusoidal dilation, and perisinusoidal or perivenular fibrosis, that could potentially increase the LSM.6 Although these histological features are less common and may not have much clinical relevance, their effect on LSM is something that needs to be appreciated more in future investigations.
Association of Deferred vs Immediate Cord Clamping With Severe Neurological Injury and Survival in Extremely Low-Gestational-Age Neonates
Authors: Abhay Lodha, Prakesh S. Shah, Amuchou Singh Soraisham, Yacov Rabi, Ayman Abou Mehrem, Nalini Singhal
Journal: JAMA Network Open (2019)

Deferred cord clamping (DCC) is recommended for term and preterm neonates to reduce neonatal complications. Information on the association of DCC with outcomes for extremely low-gestational-age neonates is limited.To compare neonatal outcomes after DCC and immediate cord clamping (ICC) in extremely low-gestational-age neonates.In this retrospective cohort study, eligible neonates born between January 1, 2011, and December 31, 2015, were divided into 2 groups: DCC and ICC. Neonates were recruited from tertiary neonatal intensive care units participating in the Canadian Neonatal Network, and analysis began in January 2018. Neonates were eligible if they were born at 22 to 28 weeks' gestational age and admitted to a participating Canadian Neonatal Network neonatal intensive care unit during the study period. Neonates who were born outside a tertiary-level neonatal intensive care unit, were moribund at birth, needed palliative care before delivery, had major congenital anomalies, or lacked cord clamping information were excluded.Composite of severe neurological injury (intraventricular hemorrhage grade ≥3 with or without persistent periventricular echogenicity) or mortality before discharge.Of 8221 admitted neonates, 4680 were included in the study, of whom 1852 (39.6%) received DCC and 2828 (60.4%) received ICC. There were 974 (52.7%) male neonates in the DCC group and 1540 (54.5%) male neonates in the ICC group. Median (interquartile range) gestational age was 27 (25-28) weeks for the DCC group and 26 (25-27) weeks for the ICC group. Median (interquartile range) birth weight was 930 (760-1120) g and 870 (700-1060) g for DCC and ICC groups, respectively. Neonates who received DCC had significantly reduced odds of the composite outcome of severe neurological injury or mortality (adjusted odds ratio [AOR], 0.80; 95% CI, 0.67-0.96), mortality (AOR, 0.74; 95% CI, 0.59-0.93), and severe neurological injury (AOR, 0.80; 95% CI, 0.64-0.99). The odds of bronchopulmonary dysplasia (AOR, 1.00; 95% CI, 0.84-1.19), retinopathy of prematurity stage 3 or higher (AOR, 0.94; 95% CI, 0.71-1.25), necrotizing enterocolitis stage 2 or higher (AOR, 0.86; 95% CI, 0.66-1.12), late-onset sepsis (AOR, 1.02; 95% CI, 0.85-1.22), and receipt of 2 or more blood transfusions (AOR, 0.93; 95% CI, 0.79-1.10) did not differ between the groups. Propensity score-matched analyses revealed lower odds of mortality (AOR, 0.79; 95% CI, 0.65-0.95), late-onset sepsis (AOR, 0.81; 95% CI, 0.69-0.95), and treatment for hypotension (AOR, 0.75; 95% CI, 0.60-0.95) in the DCC group.In this study of extremely low-gestational-age neonates who received DCC or ICC, DCC was associated with reduced risk for the composite outcome of severe neurological injury or mortality.
Biomarkers Urgently Needed to Advance Treatment Decisions for Pancreatic Ductal Adenocarcinoma
Authors: John A. Windsor
Journal: JAMA Surgery (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Increase of invasive meningococcal serogroup W disease in Europe, 2013 to 2017
Authors: Manuel Krone, Steve Gray, Raquel Abad, Anna Skoczyńska, Paola Stefanelli, Arie van der Ende, Georgina Tzanakaki, Paula Mölling, Maria João Simões, Pavla Křížová, Stéphane Emonet, Dominique A. Caugant, Maija Toropainen, Julio Vazquez, Izabela Waśko, Mirjam J. Knol, Susanne Jacobsson, Célia Rodrigues Bettencourt, Martin Musilek, Rita Born, Ulrich Vogel, Ray Borrow
Journal: Eurosurveillance (2019)

Background The total incidence of invasive meningococcal disease (IMD) in Europe has been declining in recent years; however, a rising incidence due to serogroup W (MenW), predominantly sequence type 11 (ST-11), clonal complex 11 (cc11), was reported in some European countries. Aim The aim of this study was to compile the most recent laboratory surveillance data on MenW IMD from several European countries to assess recent trends in Europe. Methods In this observational, retrospective study, IMD surveillance data collected from 2013–17 by national reference laboratories and surveillance units from 13 European countries were analysed using descriptive statistics. Results The overall incidence of IMD has been stable during the study period. Incidence of MenW IMD per 100,000 population (2013: 0.03; 2014: 0.05; 2015: 0.08; 2016: 0.11; 2017: 0.11) and the proportion of this serogroup among all invasive cases (2013: 5% (116/2,216); 2014: 9% (161/1,761); 2015: 13% (271/2,074); 2016: 17% (388/2,222); 2017: 19% (393/2,112)) continuously increased. The most affected countries were England, the Netherlands, Switzerland and Sweden. MenW was more frequent in older age groups (≥ 45 years), while the proportion in children (&lt; 15 years) was lower than in other age groups. Of the culture-confirmed MenW IMD cases, 80% (615/767) were caused by hypervirulent cc11. Conclusion During the years 2013–17, an increase in MenW IMD, mainly caused by MenW cc11, was observed in the majority of European countries. Given the unpredictable nature of meningococcal spread and the epidemiological potential of cc11, European countries may consider preventive strategies adapted to their contexts.
Image Gallery: Primary cutaneous chest‐wall osteosarcoma, an extraordinary entity
Authors: J. Ocampo‐Candiani, S.S. Ocampo‐Garza, R. Franco‐Márquez, C.D. Villarreal‐Villarreal, D.L. Villarreal‐Salinas, J.A. García‐Lozano, A. Álvarez‐Cano
Journal: British Journal of Dermatology (2019)
Balance Between Best Practice and Patient Satisfaction: Antimicrobial Stewardship in Telemedicine—Reply
Authors: Kathryn A. Martinez, Michael B. Rothberg
Journal: JAMA Internal Medicine (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal