tbuckley/cabot-search huggingface dataset:
Exploring sources of insecurity for Ethiopian Oromo and Somali women who have given birth in Kakuma Refugee Camp: A Qualitative Study
Authors: Amber Trujillo Lalla, Katherine Farrell Ginsbach, Naomi Penney, Arsity Shamsudin, Rahul Oka
Journal: PLoS Medicine (2020)

Background According to the United Nations High Commissioner for Refugees, 44,000 people are forced to flee their homes every day due to conflict or persecution. Although refugee camps are designed to provide a safe temporary location for displaced persons, increasing evidence demonstrates that the camps themselves have become stressful and dangerous long-term places—especially for women. However, there is limited literature focused on refugee women's perspectives on their insecurity. This qualitative study sought to better understand the ways in which women experienced insecurity at a refugee camp in Kenya. Methods and findings Between May 2017 and June 2017, ethnographic semi-structured interviews accompanied by observation were conducted with a snowball sampling of 20 Somali (n = 10) and Ethiopian Oromo (n = 10) women, 18 years and older, who had had at least 1 pregnancy while living in Kakuma Refugee Camp. The interviews were orally translated, transcribed, entered into Dedoose software for coding, and analyzed utilizing an ethnographic approach. Four sources of insecurity became evident: tension between refugees and the host community, intra- or intercultural conflicts, direct abuse and/or neglect by camp staff and security personnel, and unsafe situations in accessing healthcare–both in traveling to healthcare facilities and in the facilities themselves. Potential limitations include nonrandom sampling, the focus on a specific population, the inability to record interviews, and possible subtle errors in translation. Conclusions In this study, we observed that women felt insecure in almost every area of the camp, with there being no place in the camp where the women felt safe. As it is well documented that insecure and stressful settings may have deleterious effects on health, understanding the sources of insecurity for women in refugee camps can help to guide services for healthcare in displaced settings. By creating a safer environment for these women in private, in public, and in the process of accessing care in refugee camps, we can improve health for them and their babies.
PTH-095 Persistently elevated faecal calprotectin in the first 12 months of crohn’s diagnosis predicts the need for surgery: a nested case-control study
Authors: P Pavlidis, A Cockroft, LM Choong, P Ravdas, L Medcalf, J Tumova, S Chatu, R Spirajaskanthan, A Kent, G Chung-Faye, P Dubois, BH Hayee
Journal: Gut (2017)

Introduction  There is still uncertainty about the role of faecal calprotectin (FCAL) as a marker of mucosal healing in inflammatory bowel diseases. Available studies have provided evidence on the prognostic role of FCAL in predicting relapses during a short period of time but there is a lack of data on associating FCAL levels over time to hard clinical endpoints. In this study we test the hypothesis that FCAL monitoring identifies Crohn’s disease (CD) patients with persistent intestinal inflammation requiring surgery.  Method  From a large IBD cohort of patients currently under follow up at King’s College Hospital, we identified all the CD patients who were diagnosed locally and had serial FCAL in the context of their routine care (at routine appointments and during flare-ups). Utilising prospectively kept electronic patient records we identified 20 patients, meeting these monitoring criteria, who required a bowel resection for CD≥12 months after diagnosis (cases) and matched them in a 1:2 ratio with controls based on disease duration. Flares were identified based on the physician assessment and endoscopic or radiological findings. Continuous variables are summarised as medians followed by interquartile range. The Fisher exact test was used to compare categorical variables, the Mann-Whitney test for continuous variables and the ROC curve for diagnostic analysis.  Results  Median time to surgery was 9.5 years (8, 11) [control group follow up: 8 (7, 10), p=0.28]. Right hemicolectomy was the commonest procedure (14, 70%) followed by panproctocolectomy (2, 10%), small bowel resection (2, 10%) and stricturoplasty (2, 10%). The two groups did not differ in clinical characteristics or time to initiation of a biologic or immunosuppressants. Flares and hospitalisations were more common in the cases group [ 20 (100%) vs. 23 (56%), p=0.0005 and 19 (95%) vs. 19 (48%) p=0.0002, respectively]. At the time of diagnosis, there was a numerical difference in median FCAL between groups [cases: 652 ug/g (168, 1020) vs. controls: 304 ug/g (120, 750), p=0.2]. One year after the diagnosis the median FCAL (FCAL1) was higher in the cases group [ 549 ug/g (152, 1115) vs. 68 ug/g (26, 184), p=  Conclusion  FCAL is a marker of mucosal healing in CD. Frequent monitoring identifies patients with clinically meaningful levels of intestinal inflammation associated with flares, hospitalisations and surgery.  Disclosure of Interest  None Declared
ASSOCIATION BETWEEN CORONARY COLLATERALS AND MYOCARDIAL VIABILITY IN PATIENTS WITH A CHRONIC TOTAL OCCLUSION
Authors: Stefan Schumacher, Henk Everaars, Wijnand J. Stuijfzand, Jennifer W. Huynh, Pepijn Van Diemen, Roel Driessen, Michiel Bom, Ruben De Winter, Ramon B. van Loon, Peter van de Ven, Albert van Rossum, Maksymilian Opolski, Alexander Nap, Paul Knaapen
Journal: Journal of the American College of Cardiology (2020)
Genomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma
Authors: David J. H. Shih, Naema Nayyar, Ivanna Bihun, Ibiayi Dagogo-Jack, Corey M. Gill, Elisa Aquilanti, Mia Bertalan, Alexander Kaplan, Megan R. D’Andrea, Ugonma Chukwueke, Franziska Maria Ippen, Christopher Alvarez-Breckenridge, Nicholas D. Camarda, Matthew Lastrapes, Devin McCabe, Ben Kuter, Benjamin Kaufman, Matthew R. Strickland, Juan Carlos Martinez-Gutierrez, Deepika Nagabhushan, Magali De Sauvage, Michael D. White, Brandyn A. Castro, Kaitlin Hoang, Andrew Kaneb, Emily D. Batchelor, Sun Ha Paek, Sun Hye Park, Maria Martinez-Lage, Anna S. Berghoff, Parker Merrill, Elizabeth R. Gerstner, Tracy T. Batchelor, Matthew P. Frosch, Ryan P. Frazier, Darrell R. Borger, A. John Iafrate, Bruce E. Johnson, Sandro Santagata, Matthias Preusser, Daniel P. Cahill, Scott L. Carter, Priscilla K. Brastianos
Journal: Nature Genetics (2020)
TRANSRADIAL VERSUS TRANSFEMORAL INTERVENTION IN ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION PATIENTS UNDERGOING PRIMARY PERCUTANEOUS CORONARY INTERVENTION WITH DRUG-ELUTING STENTS
Authors: Seung-Woon Rha, Hu Li, Byoung Geol Choi, Se Yeon Choi
Journal: Journal of the American College of Cardiology (2014)
Huntingtin-Lowering Therapies for Huntington Disease
Authors: Blair R. Leavitt, Holly B. Kordasiewicz, Scott A. Schobel
Journal: JAMA Neurology (2020)

Huntington disease (HD) is caused by a cytosine-adenine-guanine trinucleotide repeat expansion in the huntingtin gene, HTT, that results in expression of variant (mutant) huntingtin protein (HTT). Therapeutic strategies that reduce HTT levels are currently being pursued to slow or stop disease progression in people with HD. These approaches are supported by robust preclinical data indicating that reducing variant huntingtin protein is associated with decreased HD pathology. However, the risk-benefit profile of reducing either variant HTT or both variant and wild-type HTT is currently an open question that is being addressed in ongoing clinical trials. This review aims to examine the current data available regarding altered HTT in humans, normal animals, and animal models of HD. Studies indexed in PubMed were searched using the MeSH term Huntington disease or the text words huntington or huntingtin from August 31, 1999, to August 31, 2019, with no language restrictions. Additional studies were included from the reference lists of relevant studies and the authors' personal files. Articles describing at least 1 aspect of HTT reduction were included, prioritizing those published within the last 10 years. In vivo studies were also prioritized, with a focus on studies that examined the consequences of wild-type HTT reduction in adults. In a recently completed phase 1/2a study of RG6042 in 46 adults with early manifest HD, antisense oligonucleotide-mediated partial reduction of HTT was reported to be generally safe and well tolerated over the course of 4-monthly RG6042 doses. In case studies of people with rare genetic variations in huntingtin alleles, the loss of 1 wild-type allele was not associated with HD. People with homozygous cytosine-adenine-guanine expansions developed normally until the onset of HD, although they may have experienced a more aggressive disease course. In mouse models of HD, partial reduction of HTT was beneficial, with improvements in motor, cognitive, and behavioral phenotypes. The partial reduction of wild-type HTT in normal adult rodents and nonhuman primates was generally safe and well tolerated. The body of evidence reviewed in this article indicates a positive risk-benefit profile for the partial reduction of either variant HTT alone or both variant and wild-type HTT. These strategies target the underlying cause of HD and are currently being tested in several investigational clinical trials.
A novel function of Prohibitin on melanosome transport in melanocytes
Authors: Chan Song Jo, Hye In Park, Hyun Jin Jung, Jong il Park, Ji Eun Lee, Cheol Hwan Myung, Jae Sung Hwang
Journal: Theranostics (2020)

Prohibitin (PHB, also known as PHB1 or BAP32), is a highly conserved 31kDa protein that expressed in many cellular compartments, such as mitochondria, nucleus, cytosol, and plasma membrane, and plays roles in regulating the transcription of genes, apoptosis, and mitochondrial biogenesis.There is a report that Prohibitin expression is required for the stimulation of pigmentation by melanogenin.However, no studies have been published on the function of PHB in melanocytes, especially in melanosome transport.Methods: Immunofluorescence was performed to confirm the localization of PHB.siRNA transfections, Co-immunoprecipitation, western blotting and proximity ligation assay were performed to find binding state between proteins and demonstrate functions of PHB on melanosome transport.Results: PHB is located in the melanosome and perinuclear aggregation of melanosome is induced when expression of PHB is reduced with no influence on melanin contents.PHB binds directly to Rab27a and Mlph but not Myosin-Va.Rab27a and Mlph bind to specific domains of PHB.Reduced expression of PHB led to the impaired binding affinity between Rab27a and Mlph.Conclusion: PHB regulates melanosome transport by linking to Rab27a and Mlph in melanocytes.Targeting and regulating PHB not only manages pigmentation in melanocytes, but also controls hyperpigmentation in melanoma
Alternating QRS Complex Morphology in a Man Presenting With Stroke
Authors: Jacob J. Mayfield, Nora Goldschlager
Journal: JAMA Internal Medicine (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Psychosocial Work Exposures of the Job Strain Model and Suicide in France: Findings from the STRESSJEM Prospective Study of 1.5 Million Men and Women over 26 Years of Follow-Up
Authors: Isabelle Niedhammer, Jean-Francois Chastang, Thomas Coutrot, Béatrice Geoffroy-Perez, Anthony D. LaMontagne, Allison Milner
Journal: Psychotherapy and Psychosomatics (2020)
SEX-BASED DIFFERENCES IN OUTCOMES AFTER MITRAL VALVE SURGERY FOR SEVERE ISCHEMIC MITRAL REGURGITATION: FROM THE CARDIOTHORACIC SURGICAL TRIALS NETWORK
Authors: Gennaro Giustino, Jessica Overbey, Doris Taylor, Gorav Ailawadi, Katherine Kirkwood, A. Gillinov, François Dagenais, Mary-Lu Mayer, Annetine Gelijns, Alan Moskowitz, Emilia Bagiella, Marissa Miller, Peter Smith, Patrick O'Gara, Michael Acker, Anuradha (Anu) Lala-Trindade, Judy Hung
Journal: Journal of the American College of Cardiology (2019)
TCT-736 Long-Term Durability of Transcatheter Heart Valves: Insights From Bench Testing to 25 Years
Authors: Janarthanan Sathananthan, Mark Hensey, Uri Landes, Abdullah Alkhodair, Adeeb Saiduddin, Stephanie Sellers, Anson Cheung, Sandra Lauck, Philipp Blanke, Jonathon Leipsic, Jian Ye, David Wood, John Webb
Journal: Journal of the American College of Cardiology (2019)
TRANSCATHETER EDGE-TO-EDGE REPAIR FOR SEVERE TRICUSPID REGURGITATION USING THE TRIPLE ORIFICE VERSUS BICUSPIDALIZATION TECHNIQUE
Authors: Daniel Braun, Mathias Orban, Michael Nabauer, Andrea Englmaier, Thomas Stocker, Hagl Christian, Steffen Massberg, Joerg Hausleiter
Journal: Journal of the American College of Cardiology (2018)
Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study
Authors: Kelvin Kai-Wang To, Owen Tak-Yin Tsang, Wai-Shing Leung, Anthony Raymond Tam, Tak-Chiu Wu, David Christopher Lung, Cyril Chik-Yan Yip, Jian-Piao Cai, Jacky Man-Chun Chan, Thomas Shiu-Hong Chik, Daphne Pui-Ling Lau, Chris Yau-Chung Choi, Lin-Lei Chen, Wan-Mui Chan, Kwok-Hung Chan, Jonathan Daniel Ip, Anthony Chin-Ki Ng, Rosana Wing-Shan Poon, Cui-Ting Luo, Vincent Chi-Chung Cheng, Jasper Fuk-Woo Chan, Ivan Fan-Ngai Hung, Zhiwei Chen, Honglin Chen, Kwok-Yung Yuen
Journal: The Lancet Infectious Diseases (2020)
RADIATION DOSE BENCHMARKS DURING CARDIAC CATHETERIZATION FOR CONGENITAL HEART DISEASE IN THE UNITED STATES
Authors: Sunil J. Ghelani, Andrew Glatz, Sthuthi David, Ryan Leahy, Russel Hirsch, Laurie Armsby, Sara Trucco, Ralf Holzer, Lisa Bergersen
Journal: Journal of the American College of Cardiology (2014)
WHO must prioritise the needs of older people in its response to the covid-19 pandemic
Authors: Peter G Lloyd-Sherlock, Alexandre Kalache, Martin McKee, Justin Derbyshire, Leon Geffen, F Gomez-Olive Casas
Journal: BMJ (2020)

The World Health Organization is the most influential global body guiding responses to the covid-19 pandemic. It is working around the clock to issue helpful guidance for technical experts and the general public. WHO has just issued guidance for long term care facilities,1 but it is not placed on the main page of technical guidance …
Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan
Authors: Saori Sakaue, Masahiro Kanai, Juha Karjalainen, Masato Akiyama, Mitja Kurki, Nana Matoba, Atsushi Takahashi, Makoto Hirata, Michiaki Kubo, Koichi Matsuda, Yoshinori Murakami, Mark J. Daly, Yoichiro Kamatani, Yukinori Okada
Journal: Nature Medicine (2020)
A miR-146a-5p/TRAF6/NF-kB p65 axis regulates pancreatic cancer chemoresistance: functional validation and clinical significance
Authors: Qingcai Meng, Chen Liang, Jie Hua, Bo Zhang, Jiang Liu, Yiyin Zhang, Miaoyan Wei, Xianjun Yu, Jin Xu, Si Shi
Journal: Theranostics (2020)

Background: Dysregulated microRNA (miRNA) expression in cancer can act as a key factor that modifies biological processes, including chemoresistance.Our study aimed to identify the miRNAs associated with gemcitabine (GEM) resistance in pancreatic ductal adenocarcinoma (PDAC) and to explore the potential mechanisms.Methods: The miRNA microarray was used to identify miRNAs associated with GEM resistance.Quantitative real-time PCR was used to examine miR-146a-5p expression in paired PDAC and adjacent normal tissues.Bioinformatics analysis, luciferase reporter assays, and chromatin immunoprecipitation assays were used to confirm tumor necrosis factor receptor-associated factor 6 (TRAF6) as a direct target of miR-146a-5p and to explore the potential transcription factor binding and regulation by miR-146a-5p.In vitro and in vivo experiments were performed to investigate the mechanisms.Results: MiR-146a-5p expression was significantly decreased in PDAC tissues compared with adjacent normal tissues, and miR-146a-5p expression correlated with prognosis in PDAC patients.Functional studies indicated that miR-146a-5p suppressed PDAC cell proliferation and sensitized PDAC cells to GEM chemotherapy by targeting the 3'-untranslated region (3′-UTR) of TRAF6.MiR-146a-5p was also observed to downregulate the TRAF6/NF-κB p65/P-gp axis, which regulates PDAC cell growth and chemoresistance.Conclusions: Taken together, the results indicate that the miR-146a-5p/TRAF6/NF-κB p65 axis drives pancreatic chemoresistance by regulating P-gp, suggesting that miR-146a-5p may be utilized as a new therapeutic target and prognostic marker in PDAC patients.
IgE to epitopes of Ara h 2 enhance the diagnostic accuracy of Ara h 2‐specific IgE
Authors: Alexandra F. Santos, Nuno L. Barbosa‐Morais, Barry K. Hurlburt, Sneha Ramaswamy, Oliver Hemmings, Matthew Kwok, Colin O’Rourke, Henry T. Bahnson, Hsiaopo Cheng, Louisa James, Hannah J. Gould, Brian J. Sutton, Soheila J. Maleki, Gideon Lack
Journal: Allergy (2020)

Understanding the discrepancy between IgE sensitization and allergic reactions to peanut could facilitate diagnosis and lead to novel means of treating peanut allergy.To identify differences in IgE and IgG4 binding to peanut peptides between peanut-allergic (PA) and peanut-sensitized but tolerant (PS) children.PA (n = 56), PS (n = 42) and nonsensitized nonallergic (NA, n = 10) patients were studied. Synthetic overlapping 15-mer peptides of peanut allergens (Ara h 1-11) were spotted onto microarray slides, and patients' samples were tested for IgE and IgG4 binding using immunofluorescence. IgE and IgG4 levels to selected peptides were quantified using ImmunoCAP. Diagnostic model comparisons were performed using likelihood-ratio tests between each specified nominal logistic regression models.Seven peptides on Ara h 1, Ara h 2, and Ara h 3 were bound more by IgE of PA compared to PS patients on the microarray. IgE binding to one peptide on Ara h 5 and IgG4 binding to one Ara h 9 peptide were greater in PS than in PA patients. Using ImmunoCAP, IgE to the Ara h 2 peptides enhanced the diagnostic accuracy of Ara h 2-specific IgE. Ratios of IgG4/IgE to 4 out of the 7 peptides were higher in PS than in PA subjects.Ara h 2 peptide-specific IgE added diagnostic value to Ara h 2-specific IgE. Ability of peptide-specific IgG4 to surmount their IgE counterpart seems to be important in established peanut tolerance.
Global patterns of care in advanced stage mycosis fungoides/Sezary syndrome: a multicenter retrospective follow-up study from the Cutaneous Lymphoma International Consortium (vol 28, pg 2517, 2017)
Authors: P Quaglino, M Maule, H. M Prince, P Porcu, S Horwitz, M Duvic, R Talpur, M Vermeer, M Bagot, Jose Antonio Sanches Junior
Journal: Annals of Oncology (2017)
PERCUTANEOUS CORONARY INTERVENTION IN NATIVE VESSELS WITH ANGIOGRAPHICALLY VISIBLE THROMBUS .TEMPORAL TRENDS AND THE IMPACT OF DRUG ELUTING STENTS
Authors: manivannan srinivasan, Charanjit S. Rihal, Mandeep Singh, Ryan J. Lennon, David R. Holmes, Abhiram Prasad
Journal: Journal of the American College of Cardiology (2010)
INDIVIDUAL LONG-TERM MORTALITY PREDICTION FOLLOWING EITHER CORONARY STENTING OR BYPASS SURGERY IN PATIENTS WITH MULTIVESSEL AND/OR UNPROTECTED LEFT-MAIN DISEASE: AN EXTERNAL VALIDATION OF THE SYNTAX SCORE II MODEL IN THE 1480 PATIENTS OF BEST AND PRECOMBAT RANDOMIZED CONTROLLED TRIALS
Authors: Sotomi Yohei, Cavalcante Raphael, David Klaveren, Jung-Min Ahn, Cheol W. Lee, Onuma Yoshinobu, Seung-Jung Park, Serruys Patrick
Journal: Journal of the American College of Cardiology (2016)
Covid-19 and long term conditions: what if you have cancer, diabetes, or chronic kidney disease?
Authors: Andy Extance
Journal: BMJ (2020)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Covid-19 and long term conditions: what if you have cancer, diabetes, or chronic kidney disease? Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
TCT-201 Does a Coronary Calcium Score Zero Reliably Rule Out Coronary Artery Disease in Low-to-Intermediate Risk Patients? A Coronary CTA Study
Authors: Gudrun Feuchtner, Thomas Senoner, Fabian Plank, Christoph Beyer, Fabian Steinkohl, Fabian Barbieri, Guy Friedrich, Wolfgang Dichtl
Journal: Journal of the American College of Cardiology (2019)
The Sensory Coding of Warm Perception
Authors: Ricardo Paricio-Montesinos, Frederick Schwaller, Annapoorani Udhayachandran, Florian Rau, Jan Walcher, Roberta Evangelista, Joris Vriens, Thomas Voets, James F.A. Poulet, Gary R. Lewin
Journal: Neuron (2020)

Humans detect skin temperature changes that are perceived as warm or cool. Like humans, mice report forepaw skin warming with perceptual thresholds of less than 1°C and do not confuse warm with cool. We identify two populations of polymodal C-fibers that signal warm. Warm excites one population, whereas it suppresses the ongoing cool-driven firing of the other. In the absence of the thermosensitive TRPM2 or TRPV1 ion channels, warm perception was blunted, but not abolished. In addition, trpv1:trpa1:trpm3−/− triple-mutant mice that cannot sense noxious heat detected skin warming, albeit with reduced sensitivity. In contrast, loss or local pharmacological silencing of the cool-driven TRPM8 channel abolished the ability to detect warm. Our data are not reconcilable with a labeled line model for warm perception, with receptors firing only in response to warm stimuli, but instead support a conserved dual sensory model to unambiguously detect skin warming in vertebrates.