tbuckley/cabot-search huggingface dataset:
Increased Liver Localization of Lipopolysaccharides in Human and Experimental NAFLD
Authors: Guido Carpino, Maria Del Ben, Daniele Pastori, Roberto Carnevale, Francesco Baratta, Diletta Overi, Heather Francis, Vincenzo Cardinale, Paolo Onori, Samira Safarikia, Vittoria Cammisotto, Domenico Alvaro, Gianluca Svegliati‐Baroni, Francesco Angelico, Eugenio Gaudio, Francesco Violi
Journal: Hepatology (2019)

Background and Aims Lipopolysaccharides (LPS) is increased in nonalcoholic fatty liver disease (NAFLD), but its relationship with liver inflammation is not defined. Approach and Results We studied Escherichia coli LPS in patients with biopsy‐proven NAFLD, 25 simple steatosis (nonalcoholic fatty liver) and 25 nonalcoholic steatohepatitis (NASH), and in mice with diet‐induced NASH. NASH patients had higher serum LPS and hepatocytes LPS localization than controls, which was correlated with serum zonulin and phosphorylated nuclear factor‐κB expression. Toll‐like receptor 4 positive (TLR4 + ) macrophages were higher in NASH than simple steatosis or controls and correlated with serum LPS. NASH biopsies showed a higher CD61 + platelets, and most of them were TLR4 + . TLR4 + platelets correlated with serum LPS values. In mice with NASH, LPS serum levels and LPS hepatocyte localization were increased compared with control mice and associated with nuclear factor‐κB activation. Mice on aspirin developed lower fibrosis and extent compared with untreated ones. Treatment with TLR4 inhibitor resulted in lower liver inflammation in mice with NASH. Conclusions In NAFLD, Escherichia coli LPS may increase liver damage by inducing macrophage and platelet activation through the TLR4 pathway.
Abstract 15281: Contemporary Patterns in Heart Failure Epidemiology Across Risk Factor Strata in Medicare Beneficiaries: 2011 to 2016
Authors: Rohan Khera, Lin Zhong, Joshua Parker, Sandeep R Das, Justin L Grodin, Jarett D Berry, Ambarish Pandey
Journal: Circulation (2019)

Background: Medicare beneficiaries have experienced a decreasing incidence of heart failure (HF). To inform public health strategies for HF prevention, we sought to evaluate whether these patterns ...
Endoscopy 22 (1990) 285-286
Authors: Olaf Friedrichs
Journal: Endoscopy (1991)

See also: Reply to the Letter by O. FriedrichsEndoscopy 1991; 23(02): 109-109DOI: 10.1055/s-2007-1010632 See also: Extensive Necrosis of Gastric Mucosa Following Injection Therapy of Bleeding Peptic UlcerEndoscopy 1990; 22(06): 285-286DOI: 10.1055/s-2007-1010728 See also: Epinephrine: Which Solution?Endoscopy 1991; 23(06): 351-351DOI: 10.1055/s-2007-1010716
Trends in Infant Pertussis Hospitalizations in the United States, 2009-2017
Authors: Sheree L. Boulet, Allison T. Chamberlain, Hope H. Biswas, Denise J. Jamieson
Journal: JAMA (2019)

This national database study compares pertussis hospitalizations among infants before and after the 2012 Advisory Committee on Immunization Practices recommendation that all pregnant women receive the tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine.
Allogeneic hematopoietic stem cell transplantation for aplastic anemia with pre‐transplant conditioning using fludarabine, reduced‐dose cyclophosphamide, and low‐dose thymoglobulin: A KSGCT prospective study
Authors: Shinichi Kako, Yoshinobu Kanda, Makoto Onizuka, Nobuyuki Aotsuka, Kensuke Usuki, Takayoshi Tachibana, Takeshi Kobayashi, Jun Kato, Shingo Yano, Hiroaki Shimizu, Katsuhiro Shono, Masatsugu Tanaka, Shokichi Tsukamoto, Takehiko Mori, Etsuko Yamazaki, Yuho Najima, Akira Hangaishi, Takumi Hoshino, Reiko Watanabe, Kenji Matsumoto, Shinichiro Okamoto
Journal: American Journal of Hematology (2019)

The optimal pre-transplant conditioning for aplastic anemia (AA) remains unclear. We performed a prospective study on allogeneic transplantation from a related or unrelated donor for adult patients with AA. We assessed whether reduced-dose cyclophosphamide (CY) could decrease toxicity while maintaining engraftment, and low-dose thymoglobulin could safely prevent graft-vs-host disease (GVHD). The pre-transplant conditioning regimen consisted of fludarabine 120 mg/m2 , CY 100 mg/kg, and thymoglobulin 2.5 mg/kg with or without 2 Gy of total body irradiation. Twenty-seven patients with a median age of 36 years were analyzed. Sixteen patients received graft from related donors. The stem cell source was bone marrow in 26 patients. All of the patients but one, who died early, achieved neutrophil engraftment at a median of 19 days. Mixed chimerism was observed in six and five patients at days 30 and 90, respectively. Only one patient experienced secondary engraftment failure with complete donor-type chimerism. None of the patients developed severe acute GVHD. The cumulative incidence of chronic GVHD was 37.7% at 1 year. The overall survival rate was 96.3% at 1 year and 3 years. A high EB virus-DNA load was detected in one patient at days 60. No one developed EBV-lymphoproliferative disorder within a year. The results suggest that the conditioning regimen in this study was safe and effective. However, relatively high incidence of chronic GVHD needs further improvement.
Linking Disparities to Outcomes in Pancreatic Cancer
Authors: Jason S. Gold
Journal: JAMA Surgery (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Reply to Janssen and Wouters: Loss of Alveolar Attachments as a Pathomechanistic Link between Small Airway Disease and Emphysema
Authors: Dragoş M. Vasilescu, Tillie-Louise Hackett, Fernando J. Martinez, Jeffrey L. Curtis, James C. Hogg, MeiLan K. Han
Journal: American Journal of Respiratory and Critical Care Medicine (2019)

remaining small airways have thickened walls and narrowed lumens (3).However, it remains to be determined how small airway disease leads to emphysema.Based on Vascilescu and colleagues' study in combination with decades-old research (1, 6), we propose that loss of bronchiolar-alveolar attachments is the most plausible link between small airway disease and emphysema.Lungs from smokers and lifelong nonsmokers who died suddenly of nonrespiratory causes outside of a hospital, as well as lungs/lobes from smokers who had undergone resection for localized pulmonary lesions, were examined by Saetta and colleagues (6).The internal diameter of the small airways and the alveolar size-as histological measures of small airway disease and emphysema, respectively-did not significantly differ between groups.However, reduced numbers of normal bronchiolar-alveolar attachments were found in smokers compared with never-smokers.Furthermore, the quantity and quality of the bronchiolar-alveolar attachments was related to the level of inflammation in the small airways.Figure 1 of Saetta and colleagues' article, which shows a cross-section of a nonrespiratory bronchiole surrounded by alveoli, probably says more than a thousand words.Inflammation has progressed through the entire airway wall into adjacent alveolar septa, which are relatively thin compared with the much thicker bronchiolar wall and would be the first to succumb to inflammation-induced proteolytic activity.In a microcomputed tomography analysis, Vascilescu and colleagues showed that PRM SAD was related to an increased number of obstructed terminal bronchioles, decreased terminal bronchial cross-sectional lumen area, and decreased circularity of the terminal bronchioles, whereas PRM Emph was associated with airspace size, alveolar surface area, and the number of alveolar attachments (1).Previously, Labaki and colleagues demonstrated that over a 5-year period, PRM SAD often evolves into PRM Emph (5).Together, these PRM studies suggest that lung areas with small airway disease only transform into emphysema if bronchiolar-alveolar attachments are destroyed (1, 5).Based on the above findings, we propose the following sequence of pathological steps leading from smoking to emphysema formation: deposition of cigarette smoke particles in small airways→inflammation of small airways→propagation of inflammation through the entire bronchiolar wall into adjacent alveolar septa→destruction of bronchiolar-alveolar attachments→lung parenchyma degradation proceeding from the centers of the secondary pulmonary lobules toward the surrounding interlobular septa.Disease-modifying therapies should be established to prevent destruction of bronchiolar-alveolar attachments and thus the progression from small airway disease to emphysema.
Cardiac and Pulmonary Function Late Effects after Bone Marrow Transplantation in Childhood: Prospective Study on Behalf of EBMT LEWP Group.
Authors: Cornelio Uderzo, Paola Corti, Sara Fedeli, Francesco Tana, Chiara Messina, Marta Pillon, Gloria Tridello, Claire Galambrun, Felix Zintl, Giorgio Dini, Maura Faraci, Franca Fagioli, Karsten Nysom, Amparo Verdeguer, Christian Urban, André Tichelli, Gerard Socié
Journal: Blood (2005)
Acute air pollution exposure alters neutrophils in never-smokers and at-risk humans
Authors: Denise J. Wooding, Min Hyung Ryu, Hang Li, Neil E. Alexis, Olga Pena, Chris Carlsten
Journal: European Respiratory Journal (2019)

Outdoor air pollution exposure increases chronic obstructive pulmonary disease (COPD) hospitalisations, and may contribute to COPD development. The mechanisms of harm, and the extent to which at-risk populations are more susceptible are not fully understood. Neutrophils are recruited to the lung following diesel exhaust exposure, a model of traffic-related air pollution (TRAP), but their functional role in this response is unknown. The purpose of this controlled human-exposure crossover study was to assess the effects of acute diesel exhaust exposure on neutrophil function in never-smokers and at-risk populations, with support from additional in vitro studies. 18 participants, including never-smokers (n=7), ex-smokers (n=4) and mild–moderate COPD patients (n=7), were exposed to diesel exhaust and filtered air for 2 h on separate occasions, and neutrophil function in blood (0 h and 24 h post-exposure) and bronchoalveolar lavage (24 h post-exposure) was assessed. Compared to filtered air, diesel exhaust exposure reduced the proportion of circulating band cells at 0 h, which was exaggerated in COPD patients. Diesel exhaust exposure increased the amount of neutrophil extracellular traps (NETs) in the lung across participants. COPD patients had increased peripheral neutrophil activation following diesel exhaust exposure. In vitro , suspended diesel exhaust particles increased the amount of NETs measured in isolated neutrophils. We propose NET formation as a possible mechanism through which TRAP exposure affects airway pathophysiology. In addition, COPD patients may be more prone to an activated inflammatory state following exposure. This is the first controlled human TRAP exposure study directly comparing at-risk phenotypes (COPD and ex-smokers) with lower-risk (never-smokers) participants, elucidating the human susceptibility spectrum.
CD123 (IL-3 Receptor α Chain) Neutralization by a Monoclonal Antibody Selectively Eliminates Human Acute Myeloid Leukemic Stem Cells.
Authors: Richard B. Lock, Liqing Jin, Erwin M. Lee, Hayley S. Ramshaw, Sam Busfield, Armando G. Peoppl, Lucy Wilkinson, Mark A. Guthridge, Andrew Boyd, David Gearing, Gino Vairo, Angel Lopez, John E. Dick
Journal: Blood (2007)
Preliminary Results of a Multicenter Phase II Trial of 5-Day Decitabine as Front-Line Therapy for Elderly Patients with Acute Myeloid Leukemia (AML)
Authors: Amanda F Cashen, Gary J. Schiller, Margaret R. O’Donnell, Julie S. Larsen, Akhil Baranwal, Michael T Cullen, John F DiPersio
Journal: Blood (2008)
Characterizing the effect of exposure to microgravity on anemia: more space is worse
Authors: Guy Trudel, Jessica Shafer, Odette Laneuville, Tim Ramsay
Journal: American Journal of Hematology (2019)

The effects of space travel have renewed importance with space tourism and plans for long-term missions to the moon and Mars. The study of space anemia is limited by the availability of subjects and extreme conditions. An approach using the accumulated data on human space flight may characterize space anemia. A total of 17 336 hemoglobin (Hb) concentration measures from 721 space missions and controls were used to study acute and long-term effects of duration of exposure to space on Hb decrement. Nearly half of astronauts (48%) landing after long duration missions were anemic. Returning to Earth revealed Hb decrements whose magnitude and time to recover were dependent on exposure to space: -0.61 g/dL (4%), -0.82 g/dL (5%) and -1.66 g/dL (11%) of preflight Hb for mean exposure to space of 5.4, 11.5, and 145 days, respectively. Astronauts returning from a mean 5.4 days in space took 24 days to return to preflight Hb while astronauts 11.5 to 145 days in space took 49 days. Negative effects of microgravity on Hb persisted throughout female and male astronauts' terrestrial lives (-0.001 and -0.002 mg/dL Hb respectively) for every day spent in space (both P < .05). The negative effect of exposure to space was not overcome by a statistically significant effect of being an astronaut compared to controls. Exposure to space showed a dose-response relationship with acute and chronic Hb decrements. Space anemia contributes to the deconditioning of astronauts returning to Earth, and needs to be considered for space travel to other planets, space tourism and for the care of bedridden patients who present similar changes as astronauts.
JAK2 Mutational Status, Hemostatic Risk Factors and Thrombophilic Factors in Essential Thrombocythemia (ET) Patients
Authors: Bozena Sokolowska, Aleksandra Nowaczynska, Ksenia Bykowska, Sylwia Chocholowska, Katarzyna Wejksza, Adam Walter-Cronack, Martyna Kandefer-Szerszen, Tomasz Gromek, M. Anna Kowalska, Anna Dmoszynska
Journal: Blood (2008)
介入心脏病学知识（一）——经皮介入电生理学
Authors: GerryCKaye, 肖月
Journal: BMJ (2005)

20世纪80年代以前，心脏电生理检查主要通过药物手段来验证某些心律失常的产生机制(mechanism)，以便指导药物治疗。后来，人们认识到抗心律失常药有其自身的缺陷，因而大力开展了非药物治疗技术，其中最突出的是射频消融和植入型除颤器。
Bone Tissue Engineering: Bisphosphonate‐Functionalized Scaffolds for Enhanced Bone Regeneration (Adv. Healthcare Mater. 23/2019)
Authors: Yutao Cui, Tongtong Zhu, Di Li, Zuhao Li, Yi Leng, Xuan Ji, He Liu, Dankai Wu, Jianxun Ding
Journal: Advanced Healthcare Materials (2019)

The local administration of bisphosphonates inhibits osteoclasts and promotes osteogenesis, which is a timely “rain” to improve the poor microenvironments of bone defects and promote the regeneration of bones. For this mission, in article number 1901073 by Dankai Wu and co-workers, optimized bisphosphonate-loaded composite scaffolds constructed from various matrix materials with appropriate strategies are required in clinical orthopedics, akin to soil that helps the growth of crops.
Post-production modifications of murine mesenchymal stem cell (mMSC) derived extracellular vesicles (EVs) and impact on their cellular interaction
Authors: Sarah Le Saux, Hanna Aarrass, Joséphine Lai-Kee-Him, Patrick Bron, Jean Armengaud, Guylaine Miotello, Justine Bertrand-Michel, Emeric Dubois, Simon George, Orestis Faklaris, Jean-Marie Devoisselle, Philippe Legrand, Joël Chopineau, Marie Morille
Journal: Biomaterials (2019)
Combination of Bortezomib, Melphalan, Prednisone and Thalidomide (VMPT) for Relapsed Multiple Myeloma: Results of a Phase I/II Clinical Trial.
Authors: Antonio Palumbo, Maria Teresa Ambrosini, Giulia Benevolo, Patrizia Pregno, Norbert Pescosta, Vincenzo Callea, Clotilde Cangialosi, Tommaso Caravita, Fortunato Morabito, Pellegrino Musto, Sara Bringhen, Francesca Gay, Cecilia Rus, Mario Boccadoro
Journal: Blood (2006)
指南 成人肠易激综合征在初级医疗机构的诊断和治疗：英国国家卫生和临床医疗优选研究所指南概要
Authors: Dalrymple, Bullock, 邓瑞雪
Journal: BMJ (2008)

为什么阅读本概要？ 肠易激综合征（IBS）是一个病因未明、呈慢性复发性并常持续终生的疾病。，通常还伴有结肠外症状。在临床实际工作中，常常要经过一系列不必要的检查和不恰当的转诊除外更为严重的疾病之后，才能诊断IBS。本文总结了英国国家卫生和临床医疗优选研究所（NICE）关于IBS的最新指南；该指南涵盖了此综合征的诊断和治疗，反映了患者从就诊到被诊断和治疗的全过程^2。
Chronic Graft-Versus-Host Disease after Allogenaic Bone Marrow Transplantation in Japan: Identification of Risk Factors and Prognostication.
Authors: Yoshiko Atsuta, Ritsuro Suzuki, Kazuhito Yamamoto, Seitaro Terakura, Hiroatsu Iida, Akio Kohno, Tomoki Naoe, Hiroshi Sao, Yoshihisa Kodera, Yasuo Morishima, Nobuyuki Hamajima, Yoshihisa Morishita
Journal: Blood (2005)
Machine learning for the prediction of sepsis: a systematic review and meta-analysis of diagnostic test accuracy
Authors: Lucas M. Fleuren, Thomas L. T. Klausch, Charlotte L. Zwager, Linda J. Schoonmade, Tingjie Guo, Luca F. Roggeveen, Eleonora L. Swart, Armand R. J. Girbes, Patrick Thoral, Ari Ercole, Mark Hoogendoorn, Paul W. G. Elbers
Journal: Intensive Care Medicine (2020)

Early clinical recognition of sepsis can be challenging. With the advancement of machine learning, promising real-time models to predict sepsis have emerged. We assessed their performance by carrying out a systematic review and meta-analysis. A systematic search was performed in PubMed, Embase.com and Scopus. Studies targeting sepsis, severe sepsis or septic shock in any hospital setting were eligible for inclusion. The index test was any supervised machine learning model for real-time prediction of these conditions. Quality of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology, with a tailored Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) checklist to evaluate risk of bias. Models with a reported area under the curve of the receiver operating characteristic (AUROC) metric were meta-analyzed to identify strongest contributors to model performance. After screening, a total of 28 papers were eligible for synthesis, from which 130 models were extracted. The majority of papers were developed in the intensive care unit (ICU, n = 15; 54%), followed by hospital wards (n = 7; 25%), the emergency department (ED, n = 4; 14%) and all of these settings (n = 2; 7%). For the prediction of sepsis, diagnostic test accuracy assessed by the AUROC ranged from 0.68–0.99 in the ICU, to 0.96–0.98 in-hospital and 0.87 to 0.97 in the ED. Varying sepsis definitions limit pooling of the performance across studies. Only three papers clinically implemented models with mixed results. In the multivariate analysis, temperature, lab values, and model type contributed most to model performance. This systematic review and meta-analysis show that on retrospective data, individual machine learning models can accurately predict sepsis onset ahead of time. Although they present alternatives to traditional scoring systems, between-study heterogeneity limits the assessment of pooled results. Systematic reporting and clinical implementation studies are needed to bridge the gap between bytes and bedside.
<sup>62</sup>cuatsm and <sup>62</sup>cuptsm PET is a useful imaging tool for hypoxia and perfusion in lung cancer.
Authors: Tian Zhang, Shiva K. Das, Jeffrey Crawford, Terence Wong, Mark W. Dewhirst, Gordana Vlahovic
Journal: Journal of Clinical Oncology (2013)

e22166 Background: Hypoxia is a characteristic of many tumors and portends a worse prognosis in lung, cervical, prostate, and rectal cancers. Unlike the others, lung cancers present a unique challenge in measuring hypoxia, with invasive biopsies and higher rates of complications. Noninvasive imaging studies detecting hypoxia using isotopes of copper-diacetyl-bis (N4-methylthiosemicarbazone), CuATSM, have predicted prognosis and treatment outcomes in some small feasibility trials. These images, however, may not identify all areas of hypoxia. Hence, we hypothesize that the addition of another positron emission tomography (PET) imaging agent, copper-pyruvaldehyde-bis (N4-methylthiosemicarbazone), 62 CuPTSM, which can detect areas of perfusion, can augment the information obtained in 62 CuATSM PET scans. Methods: In order to characterize tumors based on both perfusion and hypoxia, ten patients were studied using both 62 CuATSM and 62 CuPTSM PET scans. All patients signed informed consent; the protocol was approved by the Duke University Medical Center institutional review board. 62 CuATSM and 62 CuPTSM SUV values at steady state were tabulated and the ratios of 62 CuATSM to 62 CuPTSM calculated. In addition, proteomic arrays looking at specific proangiogenic, survival, and proinflammatory targets were assessed. Results: Six out of ten patients had fully evaluable PET scans. Our initial experience of characterizing lung tumor hypoxia using 62 CuATSM/ 62 CuPTSM PET scans showed that visualization of areas with hypoxia normalized for perfusion is feasible. All studied tumors exhibited some hypoxia. Despite the small sample size, a positive relationship was noted between serum epidermal growth factor (EGF) levels and 62 CuATSM detected hypoxia. Conclusions: This initial series of 62 CuATSM/ 62 CuPTSM PET scans demonstrate that evaluating pulmonary lesions by visualizing hypoxia and perfusion is a feasible and novel technique to provide more information. Further investigation is warranted to assess the potential role of 62 CuATSM and 62 CuPTSM PET imaging techniques combined with proteomics as alternatives to invasive biopsy techniques in clinical care.
A134T, G156A and G1333A SNPs in the CD177 Gene Are Associated with Atypical Expression of Human Neutrophil Antigen 2a (HNA-2a)
Authors: Elyse Moritz, Akemi Kuroda Chiba, Dulcinéia M Albuquerque, Fernando F Costa, Mihoko Yamamoto, Jose Orlando Bordin
Journal: Blood (2008)
重症监护治疗学（13）：治疗效果的资料与评分系统
Authors: KevinGunning, KathyRowan
Journal: BMJ (2002)

重症监护在过去的 30多年中有了很大发展 ,但在临床意义上 ,何为有效 ?何为无效 ?尚无严格的科学依据。没有这些数据资料 ,从事重症监护的医生通常要对采取何种治疗措施能使哪些病人获益最大做出判断。制定评分系统是为了便于对疾病严重性的评估和监测。这些系统使重症监护方面的研究具有可比性 ,并能正确对其作出评估。 为什么需要评分系统 ? 虽然严格的试验或大样本随机抽样对照试验是评估现存或新干预方法的金标准 ,但这些在重症监护医学中并不一定总能行得通。举例来说 ,随机分配重病人使其接受重症监护或一般看护治疗是不道德的。替代的办法是将重症病人的监护治疗作为其自然治疗过程的一部分进行观察。但是 ,在
Molecular Characterization of Three New Mutant Enzymes of Pyrimidine 5′-Nucleotidase Causing Hereditary Hemolytic Anemia.
Authors: Laurent R. Chiarelli, Simone M. Morera, Paola Rognoni, Paola Bianchi, Elisa Fermo, Alessandro Galizzi, Alberto Zanella, Giovanna Valentini
Journal: Blood (2007)
Epitope-specific airway-resident CD4+ T cell dynamics during experimental human RSV infection
Authors: Aleks Guvenel, Agnieszka Jozwik, Stephanie Ascough, Seng Kuong Ung, Suzanna Paterson, Mohini Kalyan, Zoe Gardener, Emma Bergstrom, Satwik Kar, Maximillian S. Habibi, Allan Paras, Jie Zhu, Mirae Park, Jaideep Dhariwal, Mark Almond, Ernie H.C. Wong, Annemarie Sykes, Jerico Del Rosario, Maria-Belen Trujillo-Torralbo, Patrick Mallia, John Sidney, Bjoern Peters, Onn Min Kon, Alessandro Sette, Sebastian L. Johnston, Peter J. Openshaw, Christopher Chiu
Journal: Journal of Clinical Investigation (2019)

BACKGROUND. Respiratory syncytial virus (RSV) is an important cause of acute pulmonary disease and one of the last remaining major infections of childhood for which there is no vaccine. CD4+ T cells play a key role in antiviral immunity, but they have been little studied in the human lung.