tbuckley/cabot-search huggingface dataset:
GASTROPANCREATIC FISTULA WITH FISH-MOUTH SIGN
Authors: G Ramos, S Santos, R Saraiva, I Canha, DF Carvalho
Journal: Endoscopy (2020)

We report a 72-year-old female with several pancreatitis episodes, including infected pancreatic fluid collection(PFC) drained at another institution. She was referred due to dilation of main pancreatic duct(MPD) in imaging and communication with gastric antrum. Endoscopically, a fistulous orifice in the antrum was apparent, with gelatinous content; endoscopic ultrasound showed dilated MPD (40mm-body) with loss of interface with the stomach. MPD fine-needle aspiration revealed a mucinous content. Cytologic analysis confirmed high-grade IPMN. Although IPMN can fistulize, in this patient most likely resulted from a prior procedure, underlying the importance of correct workup prior to PFCs drainage to exclude cyst neoplasm.
THE DIAGNOSTIC USEFULNESS OF E-CADHERIN AND EPIDERMAL GROWTH FACTOR (EGF) IN SYMPTOMATIC GASTRO-ESOPHAGEAL REFLUX DISEASE
Authors: L Ciavarella, E Sanvito, M Antonelli, E Ribichini, C Belloni, R Daverio, L Massimo, PA Testoni, S Passaretti
Journal: Endoscopy (2020)

Aims The aim of our study is to evaluate the utility of fasting E-cadherin and EGF levels in serum and saliva as a non-invasive test to predict the presence of gastro-esophageal reflux disease in patients with typical, atypical or extra-esophageal symptoms compared with healthy volunteers and to find any correlation among E-cadherin or EGF levels and patients’ characteristics, symptoms or endoscopic findings.
A prospective investigation of chemotherapy induced neutropenia (CIN) and quality of life (QoL)
Authors: B. V. Fortner, A. C. Houts, G. Johnson, L. S. Schwartzberg
Journal: Journal of Clinical Oncology (2005)

8178 Background: A previous prospective study (Fortner, et al, in press) suggested QoL decline is correlated with grade 4 chemotherapy-induced neutropenia (Gr4N). The purpose of this study was to prospectively examine this relationship with additional validated measures. Methods: Subjects were adult cancer patients receiving 1st or 2nd line chemotherapy with moderate to high risk for Gr3N. Subjects with baseline neutrophils or hemoglobin outside normal limits or who were scheduled to receive prophylactic colony stimulating factor (CSF) or anti-infectives were excluded. Subjects completed the Rotterdam Symptom Checklist (RSCL), SF-36 Health Survey (SF-36), Hospital Anxiety and Depression Scale (HADS), and the Cancer Care Monitor - Medical Isolation Scale (CCM-MIS) through the first cycle of chemotherapy on days 0, 7, 14, and 21. Absolute neutrophil count (ANC) was assessed on day 0, 4, 7, 9, 11, 14 and 21. Results: 85 subjects (mean age = 58.4 [SD = 11.8], 73% female, 68% Caucasian) participated. Primary tumor types were breast (51%), lung (27%), and genitourinary (9%). 92% were receiving first line chemotherapy. A mixed models repeated measures ANOVA was used to model QoL change as a function of baseline characteristics (age, gender, SF-36 Summary scores, baseline of respective measure), day of cycle, and Gr4N or grade 3 and 4 neutropenia (Gr3/4N). Day of cycle and baseline observation of the respective measure were significant predictors across all models. Gr34N was a significant predictor (p. < .05) of: RSCL physical symptoms, SF-36 physical functioning, SF-36 social functioning. A trend (p.<0.1) was observed for: RSCL psychological symptoms, HADS depression, CCM-MIS. Gr4N was a significant predictor of SF-36 physical functioning, and a trend was observed for HADS depression and CCM-MIS. Conclusions: These findings are consistent with previous findings showing a significant decline in QoL with the onset of severe CIN. Further studies are needed to determine if ANC has a causal relationship to patient reported symptoms and QoL and the potential QoL benefits of CIN management. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Amgen Amgen Amgen
FEASIBILITY, SAFETY AND EFFECTIVENESS OF ENDOSCOPIC SUBMUCOSAL DISSECTION OF GASTROINTESTINAL LESIONS IN OUTPATIENTS VS INPATIENTS
Authors: S Sferrazza, M Maida, M Jovani, F Vieceli, GD Pretis, R Maselli, A Repici
Journal: Endoscopy (2020)

Aims Endoscopic submucosal dissection (ESD) allows ‘en-bloc’ resection of superficial gastrointestinal neoplasms. Usually, ESDs are performed as inpatients. This study aimed to assess the feasibility, safety and efficacy of ESD in outpatients compared to inpatients.
Novel Stool-Based Protein Biomarkers for Improved Colorectal Cancer Screening
Authors: Linda J.W. Bosch, Meike de Wit, Thang V. Pham, Veerle M.H. Coupé, Annemieke C. Hiemstra, Sander R. Piersma, Gideon Oudgenoeg, George L. Scheffer, Sandra Mongera, Jochim Terhaar Sive Droste, Frank A. Oort, Sietze T. van Turenhout, Ilhame Ben Larbi, Joost Louwagie, Wim van Criekinge, Rene W.M. van der Hulst, Chris J.J. Mulder, Beatriz Carvalho, Remond J.A. Fijneman, Connie R. Jimenez, Gerrit A. Meijer
Journal: Annals of Internal Medicine (2017)

Fecal immunochemical tests detecting hemoglobin are widely used for noninvasive colorectal cancer (CRC) screening, but their sensitivity leaves room for improvement. This proof-of-concept study ide...
Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV)
Authors: Francis S. Collins, Paul Stoffels
Journal: JAMA (2020)

Shengli Xia, BS; Kai Duan, PhD; Yuntao Zhang, PhD; Dongyang Zhao, BS; Huajun Zhang, PhD; Zhiqiang Xie, MD; Xinguo Li, MD; Cheng Peng, MD; Yanbo Zhang, MD; Wei Zhang, MD; Yunkai Yang, MD; Wei Chen, MSc; Xiaoxiao Gao, PhD; Wangyang You, MD; Xuewei Wang, MD; Zejun Wang, PhD; Zhengli Shi, PhD; Yanxia Wang, BS; Xuqin Yang, MD; Lianghao Zhang, MSc; Lili Huang, BS; Qian Wang, MD; Jia Lu, PhD; Yongli Yang, PhD; Jing Guo, PhD; Wei Zhou, PhD; Xin Wan, MD; Cong Wu, MD; Wenhui Wang, MD; Shihe Huang, PhD; Jianhui Du, MD; Ziyan Meng, MD; An Pan, PhD; Zhiming Yuan, PhD; Shuo Shen, PhD; Wanshen Guo, BS; Xiaoming Yang, MD
ENDOSCOPIC STENTING VERSUS ENDOSCOPIC VACUUM THERAPY IN THE MANAGEMENT OF UPPER GASTROINTESTINAL TRANSMURAL DEFECTS: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: ES do Monte Junior, DTH de Moura, IB Ribeiro, S Singh, M Coronel, C Thompson, EGH de Moura
Journal: Endoscopy (2020)

Aims Surgical management of gastrointestinal (GI) transmural defects like perforations, leaks, and fistulas are associated with high morbidity and mortality rates. Several endoscopic techniques are now available, and endoscopy has become the first-line approach to manage these conditions. Among the endoscopic therapies, placement of a self-expanding metal stents (SEMS) is the most widely used therapy. Whereas, endoscopic vacuum therapy (EVT) has recently emerged as a safe and effective tool that promotes healing via macrodeformation, microdeformation, changes in perfusion, exudate control, and bacterial clearance. We aimed to conduct a systematic review and meta-analysis of available literature in an attempt to compare SEMS and EVT for the management of upper GI transmural defects.
GASTROINTESTINAL FOREIGN BODY IN KOREAN CHILDREN: A NATIONWIDE STUDY
Authors: E Ryoo, TH Kim, JS Moon, JS Ko, BH Choe, B Kang, JY Choe, HJ Jang, KS Lee, HJ Lee, YM Lee, MJ Kim, JM Yoon, DY Yi, KR Moon, KM Kim, SH Oh, H Tchah
Journal: Endoscopy (2020)

Aims Many children suffer from ingestion of foreign body (FB) and sometimes require an emergency endoscopy or surgery. Up to now, few domestic data study on FB ingestion in children by pediatric gastroenterologists has been reported. This study aims to investigate the clinical characteristics and outcomes of FB ingestion in children and clarify proper tools for evaluating FB patients.
TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination
Authors: Gangliang Wang, Shuai Chen, Ziang Xie, Shuying Shen, Wenbin Xu, Wenxiang Chen, Xiang Li, Yizheng Wu, Liangping Li, Bin Liu, Xianjun Ding, An Qin, Shunwu Fan
Journal: Annals of the Rheumatic Diseases (2020)

FBXO6, a component of the ubiquitin E3 ligases, has been shown to bind high mannose N-linked glycoproteins and act as ubiquitin ligase subunits. Most proteins in the secretory pathway, such as matrix metalloproteinases, are modified with N-glycans and play important roles in the development of osteoarthritis (OA). However, whether FBXO6 exerts regulatory effects on the pathogenesis of OA remains undefined.The expression of FBXO6 was examined in the cartilage of human and multiple mouse OA models. The role of FBXO6 in cartilage degeneration was analysed with global FBXO6-/- mice, transgenic Col2a1-CreERT2;FBXO6f/f mice. The FBXO6 interacting partner MMP14 and its regulatory transcriptional factor SMAD2/3 were identified and validated in different pathological models as well as SMAD2-/- mice.The expression of FBXO6 decreased in the cartilage from human OA samples, anterior cruciate ligament transaction (ACLT) -induced OA samples, spontaneous OA STR/ort samples and aged mice samples. Global knockout or conditional knockout of FBXO6 in cartilage promoted experimental OA process. The molecular mechanism study revealed that FBXO6 decreased MMP14 by ubiquitination and degradation, leading to inhibited proteolytic activation of MMP13. Interestingly, FBXO6 expression is regulated by transforming growth factor β (TGFβ)-SMAD2/3 signalling pathway. Therefore, the overexpression of FBXO6 protected mice from post-injury OA development.TGFβ-SMAD2/3 signalling pathway suppressed MMP13 activation by upregulating of FBXO6 transcription and consequently promoting MMP14 proteasomal degradation. Inducement of FBXO6 expression in OA cartilage might provide a promising OA therapeutic strategy.
RED-GREEN-BLUE (RGB) IMAGE ANALYSIS OF PANCREATIC MASS-ELASTOGRAPHIES IN ENDOSCOPIC ULTRASOUND (EUS) CAN PREDICT MALIGNANCY- A PILOT STUDY
Authors: M Razpotnik, S Bota, G Essler, J Weber-Eibel, M Peck-Radosavljevic
Journal: Endoscopy (2020)

Aims To investigate the accuracy of quantitative image analysis of EUS-elastographies (tissue elasticity) to predict malignancy of solid pancreatic lesions.
IS ERCP TRAINING MODEL (THE BOSKOSKI-COSTAMAGNA ERCP TRAINER) USEFUL FOR TRAINEES?
Authors: Y Suzuki, S Nishigori, J Hamanaka, H Oka, H Okazaki, S Maeda
Journal: Endoscopy (2020)

Aims There are few reports on ERCP training program using model. The aim of this study was to assess the usefulness of our training using the Boskoski-Costamagna ERCP Trainer.
CLINICAL AND ENDOSCOPIC DIFFERENCES BETWEEN SESSILE SERRATED ADENOMA/POLYP WITH OR WITHOUT CYTOLOGIC DYSPLASIA AND HYPERPLASTIC POLYP
Authors: HW Kim, SB Park, DH Kang, SJ Kim, HS Nam, DG Ryu
Journal: Endoscopy (2020)

Aims Sessile serrated adenoma/polyps (SSAPs) are known to develop cancer by the serrated neoplasia pathway. Endoscopic features of SSAPs are well presented in NICE and WASP classification, but SSAPs are often difficult to distinguish hyperplastic polyp (HP) and predict the accompanying dysplasia. We aimed to evaluate the clinical and endoscopic differences between SSAPs with or without cytologic dysplasia and HP.
Covid-19: Intensive care consultant has suspension cut short to help fight pandemic
Authors: Clare Dyer
Journal: BMJ (2020)

A consultant in intensive care medicine and anaesthesia who was suspended from the UK medical register has had his 12 month suspension cut short after his NHS trust wrote to the General Medical Council (GMC) without his knowledge, saying that he was needed to help fight the covid-19 pandemic.The GMC issued new guidance for medical practitioners' tribunals in March on requests to relax or revoke sanctions or interim orders in response to covid-19.The guidance advises that the risk of harm to the public from relaxing or revoking sanctions should be weighed against the risk of harm presented by the coronavirus and the doctor's ability to alleviate it.
Tumour-specific fluorescence-guided surgery for pancreatic cancer using panitumumab-IRDye800CW: a phase 1 single-centre, open-label, single-arm, dose-escalation study
Authors: Guolan Lu, Nynke S van den Berg, Brock A Martin, Naoki Nishio, Zachary P Hart, Stan van Keulen, Shayan Fakurnejad, Stefania U Chirita, Roan C Raymundo, Grace Yi, Quan Zhou, George A Fisher, Eben L Rosenthal, George A Poultsides
Journal: The Lancet. Gastroenterology & hepatology (2020)
Patterns in Geographic Access to Health Care Facilities Across Neighborhoods in the United States Based on Data From the National Establishment Time-Series Between 2000 and 2014
Authors: Jennifer Tsui, Jana A. Hirsch, Felicia J. Bayer, James W. Quinn, Jesse Cahill, David Siscovick, Gina S. Lovasi
Journal: JAMA Network Open (2020)

<h3>Importance</h3> The association between proximity to health care facilities and improved disease management and population health has been documented, but little is known about small-area health care environments and how the presence of health care facilities has changed over time during recent health system and policy change. <h3>Objective</h3> To examine geographic access to health care facilities across neighborhoods in the United States over a 15-year period. <h3>Design, Setting, and Participants</h3> Using longitudinal business data from the National Establishment Time-Series, this cross-sectional study examined the presence of and change in ambulatory care facilities and pharmacies and drugstores in census tracts (CTs) throughout the continental United States between 2000 and 2014. Between January and April 2019, multinomial logistic regression was used to estimate associations between health care facility presence and neighborhood sociodemographic characteristics over time. <h3>Main Outcomes and Measures</h3> Change in health care facility presence was measured as never present, lost, gained, or always present between 2000 and 2014. Neighborhood sociodemographic characteristics (ie, CTs) and their change over time were measured from US Census reports (2000 and 2010) and the American Community Survey (2008-2012). <h3>Results</h3> Among 72 246 included CTs, the percentage of non–US-born residents, residents 75 years or older, poverty status, and population density increased, and 8.1% of CTs showed a change in the racial/ethnic composition of an area from predominantly non-Hispanic (NH) white to other racial/ethnic composition categories between 2000 and 2010. The presence of ambulatory care facilities increased from a mean (SD) of 7.7 (15.9) per CT in 2000 to 13.0 (22.9) per CT in 2014, and the presence of pharmacies and drugstores increased from a mean (SD) of 0.6 (1.0) per CT in 2000 to 0.9 (1.4) per CT in 2014. Census tracts with predominantly NH black individuals (adjusted odds ratio [aOR], 2.37; 95% CI, 2.03-2.77), Hispanic/Latino individuals (aOR 1.30; 95% CI, 1.00-1.69), and racially/ethnically mixed individuals (aOR, 1.53; 95% CI, 1.33-1.77) in 2000 had higher odds of losing health care facilities between 2000 and 2014 compared with CTs with predominantly NH white individuals, after controlling for other neighborhood characteristics. Census tracts of geographic areas with higher levels of poverty in 2000 also had higher odds of losing health care facilities between 2000 and 2014 (aOR, 1.12; 95% CI, 1.05-1.19). <h3>Conclusions and Relevance</h3> Differential change was found in the presence of health care facilities across neighborhoods over time, indicating the need to monitor and address the spatial distribution of health care resources within the context of population health disparities.
Response to: ‘Use of tanezumab for patients with hip and knee osteoarthritis with reference to a randomised clinical trial by Berenbaum and colleagues’ by Riddle and Perera
Authors: Francis Berenbaum, Francisco J Blanco, Ali Guermazi, Kenji Miki, Takaharu Yamabe, Lars Viktrup, Rod Junor, William Carey, Mark T Brown, Christine R West, Kenneth M Verburg
Journal: Annals of the Rheumatic Diseases (2020)

We thank Riddle and Perera1 for their interest in our publication.2 In our article, we adhered to recognised statistical methods and appropriate association with meaningfulness. We agree with the American Statistical Association guidance that a statistically significant effect does not inform its size or importance,3 and therefore, a change needs to be associated with clinical impact.

In this study (ClinicalTrials.gov: NCT02709486), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain subscale and Physical Function subscale were measured using an 11-point numeric rating scale (specifically, the WOMAC NRS3.1 V5 US). As specified in the WOMAC User Guide, each WOMAC subscale is to be summed and can be normalised on a 0–10 scale for the numeric rating scale. Therefore, in this study, the five questions for the Pain subscale and the 17 questions for the Physical Function subscale were summed and averaged, respectively, to determine each mean subscale score. This differs from subscale scores that are not normalised …
Overuse of Testing in Preoperative Evaluation and Syncope
Authors: Allen Kachalia, Aaron Berg, Angela Fagerlin, Karen E. Fowler, Timothy P. Hofer, Scott A. Flanders, Sanjay Saint
Journal: Annals of Internal Medicine (2015)

Health care reform efforts and initiatives seek to improve quality and reduce costs by eliminating unnecessary care. In this study, the authors randomly selected and surveyed physicians practicing ...
EFFECT OF WEEKEND HOSPITAL ADMISSION ON LOWER GASTROINTESTINAL BLEEDING OUTCOMES
Authors: S Machlab, P Garcia - Iglesias, E Martinez-Bauer, E Brunet, L Hernandez, S Marin, M Raurich, V Puig-Divi, L Melcarne, X Calvet, F Junquera, RC Fernandez, MG Montero, E Brullet, A Lira
Journal: Endoscopy (2020)

Aims The aim of this study is to investigate whether adverse outcomes for patients admitted with LGB differ depending on weekend versus weekday admission and determine whether any such differences are mediated by the timing of colonoscopy.
THE USE OF INTEGRATED 2D AND 3D BASED DEEP NEURAL NETWORK AS AN ADJUNCT DETECTION TOOL IN COLONOSCOPY
Authors: A Bobade, S Yi, JA Leighton, S Pasha, FC Ramirez
Journal: Endoscopy (2020)

Aims Deep convolution neural network (CNN) has been studied for identifying lesions in colonoscopy videos using colored 2D images. The benefit from using a 3D based CNN is unknown. The aim of this study is to assess the utility of an integrated CNN framework that utilizes color (2D) and depth (3D) information for automated lesion detection
An invited commentary on “Liu Z, Ding Z, Guan X, Zhag Y, Wang X, Khan JS. Optimizing response in surgical systems during and after COVID-19 pandemic: Lessons from China and the UK – Perspective. Int J Surg 2020 May 4;78:156-159.″
Authors: Aaron Shanker, Tariq Siddiqui, Mohammad Bashashati
Journal: International Journal of Surgery (2020)
Efficacity of a sequential treatment by anti-CD 20 monoclonal antibody and belimumab in type II cryoglobulinaemia associated with primary Sjögren syndrome refractory to rituximab alone
Authors: Kevin Chevalier, Rakiba Belkhir, Raphaele Seror, Xavier Mariette, Gaetane Nocturne
Journal: Annals of the Rheumatic Diseases (2020)

Primary Sjogren syndrome (pSS) may be complicated by type II cryoglobulinaemia in approximately 5%–20% of patients. pSS is actually the first aetiology of type II cryoglobulinaemia,1 the latter being associated with development of vasculitis, extraglandular involvement, increased risk of B-cell lymphoma and decrease in survival.

Rituximab, a monoclonal anti-CD20 antibody, is frequently used in the treatment of cryoglobulinaemia. B-cell activating factor (BAFF), also known as B-lymphocyte stimulator, plays a key role in the survival and activation of B cells. An elevation in BAFF levels occurs after B-cell depletion induced by rituximab.2 It is the consequence of a decrease in B cells that are the most important reservoir of cells expressing the BAFF receptor and of an upregulation of BAFF mRNA.3 The association of belimumab with rituximab could be synergistic and is currently evaluated in pSS and systemic lupus erythematosus.4 

We report three cases of patients with refractory cryoglobulinaemic vasculitis complicating pSS successfully treated by the combination of an anti-CD20 therapy followed by belimumab (table 1, …
Abstract 1933: Alteration of the protein tyrosine phosphatome in cancer
Authors: Damian Moskal, Nicholas K. Tonks, Robert Lucito
Journal: Cancer Research (2015)

Abstract While the importance of receptor tyrosine kinase pathways in cancer has and continues to be carefully studied there are more than 100 tyrosine phosphatases, either receptor or non receptor, that also play an important role in cancer development. However there has been no comprehensive study of all PTPs or the protein tyrosine phosphatome (PTPome), to identify which have a role in cancer. We as a cancer community are fortunate to have access to a wide array of data types from a number of data sources such as TCGA, where we can determine if the PTPs are mis regulated in more than 20 types of cancers, totaling close to 4,000 samples. We utilized TCGA data for all tumor types with mature data sub setting the data to analyze the PTPome for all data types including expression, methylation, copy number and sequence data where available. Our intention was to use the genomic data to identify PTPs that were important to specific cancers as well as to understand which PTPs play an important role in multiple tumor types. Presently we have studied copy number variations, expression and methylation changes in 20 different tumor types. Thus far, copy number variations, as could be expected were extremely useful to determine the primary mutations in specific tumor types as well as PTPs that are found recurrently in multiple tumor types but not as useful to identify a number of PTPs that are co-altered or altered in the same individual tumors. We were surprised to find that the methylation data was not very useful to identify alterations but could use the methylation data to corroborate other alterations found. Presently we are also using the methylation data to determine if it can be used to identify possible clinical correlations. The expression data has been very useful to identify co-altered PTPs. Interestingly we found several PTPs that are altered together (for example, PTPN6, PTPN7, PTPN18, PTPN22, PTPRC, DUSP2 and DUSP22 with an overall pvalue of 0.02 and much lower if measured between any two PTPs in this list). In addition we have found PTPs that are co-altered in a specific tumor type but possibly more interesting PTPs that are co-altered in a number of tumor types. We are now studying if our results can be used to determine if these PTPs represent multiple specific pathways that are advantageously altered in carcinogenesis. Citation Format: Damian Moskal, Nicholas K. Tonks, Robert Lucito. Alteration of the protein tyrosine phosphatome in cancer. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1933. doi:10.1158/1538-7445.AM2015-1933
MDH1-mediated malate-aspartate NADH shuttle maintains the activity levels of fetal liver hematopoietic stem cells
Authors: Hao Gu, Chiqi Chen, Xiaoxin Hao, Ni Su, Dan Huang, Yejun Zou, Shu-Hai Lin, Xianjun Chen, Denghao Zheng, Ligen Liu, Zhuo Yu, Li Xie, Yaping Zhang, Xiaoxiao He, Xiaoyun Lai, Xiaocui Zhang, Guo-Qiang Chen, Yuzheng Zhao, Yi Yang, Joseph Loscalzo, Junke Zheng
Journal: Blood (2020)
PREDICTORS OF POSITIVE BILIARY BRUSH CYTOLOGY IN PATIENTS WITH BILIARY STRICTURE
Authors: KR Joo, MK Chae
Journal: Endoscopy (2020)

Aims Bile duct brush cytology during Endoscopic Retrograde Cholangiopancreatography (ERCP) is the standard method of sampling a biliary stricture. We aimed to find out predictors of positive brush cytology during the ERCP in patients with biliary stricture.