AB0748 IMPORTANCE OF COMORBIDITIES IN PATIENTS WITH ARTHRITIS PSORIATIC
Authors: I. Braña Abascal, S. M. Rojas Herrera, M. Priego Fernandez-Martos, J. Malave Calzada, D. Fernandez Lozano, R. Veroz Gonzalez, J. J. Aznar Sanchez, E. Chamizo Carmona
Journal: Annals of the Rheumatic Diseases (2020)

Background: Cardiovascular diseases are more prevalent in inflammatory arthritis, such as psoriatic arthropathy (PsA), than in general population. An increase in the presence of anxiety-depressive disorders has been also described in patients with psoriatic disease. Objectives: To assess the prevalence of comorbilities in a cohort of patient with PsA, especially cardiovascular events and anxiety-depression disorders. Methods: Observational, cross- sectional study of a cohort of patients with PsA from a monographic clinical unit in a rheumatology department to describe the presence of comorbidities: hypertension, diabetes, hyperlipemia, hyperuricemia, smoking, obesity, depression and isquemic heart disease (IHD). The comorbidities were analyzed according to the type of disease: peripheral, mixed and axial involvement. For statistical analysis SPSS v.25 was used. Results: We included 145 patients: 84 men and 61 women. The mean age at diagnosis was 45,4 (± 12,9) years, and the mean time of evolution was 9.3 (± 6,2) years. No significant difference between genders was observed. Peripheral involvement was observed in 94 (64,8%), mixed 31 (21,4%) and axial involvement in 20 (13,8%). We did not find any differences between gender for peripheral and axial pattern, however 31% of men versus 8,2% of women presented a mixed pattern. [OR=5 (1,8-14), p= 0,001]. The most common comorbidities founded were hyperlipemia, overweight and arterial hypertension. Table 1 shows all the comorbidities studied and their distribution by pattern. Patients with mixed involvement had a higher proportion of smokers [OR=2,9 (1,2-7,3), p=0,02] and a tendency to higher IHD [OR=2,8 (0,9-8,6), p=0,06]. Overweight was significantly lower in axial pattern patients [OR=0,4 (0,2-0,8), p=0,01] and higher in the peripheral ones [OR=1,5 (1,1-2,1), p=0,01]. IHD was prevalent in patients of our cohort (10,3%), it was significantly higher in men than in women [OR=12 (1,5-93,9), p=0,003], and more likely in mixed involvement (19,4%). Males with PsA also developed hyperuricemia more frequently [OR=6,5 (2,5-16,9), p&lt;0,0001]. Metabolic syndrome was found in 15.9%, but there was no significant difference among the patterns. Although, it was associated with hyperuricemia [OR=21,6 (6,7-69,8), p&lt; 0,0001] and ischemic heart disease [OR=12,4 (3,8-40,1), p&lt; 0,0001]. Finally, the rest of the comorbidities analyzed did not show significant difference in gender and pattern of disease. Conclusion: In our cohort, a high prevalence of comorbidities was found, especially hyperlipemia, metabolic syndrome and IHD. In general, overweight (BMI &gt; 25) was very common and was associated to a peripheral disease while the axial disease showed as a protective factor. Table 1. Comorbilities in patterns of disease. PsA (n=145) Peripheral disease (n=94) Mixed disease (n=31) Axial disease (n=20) Age at diagnosis, year (DE) 45,4 (±13) 45,7 (±12,9) 45 (±13) 43,9 (±13,8) Time of evolution, years (DE) 9,3 (±6,2) 9,6 (±6,5) 8,6 (±5,4) 7,3 (±2,9) Men, n (%) 84 (57,9%) 48 (51,1%) 26 (83,9%) 10 (50%) Women n (%) 61 (42,1%) 46 (48,9%) 5 (16,1%) 10 (50%) Hyperlipemia, n (%) 87 (60%) 60 (63,8%) 17 (54,8%) 10 (50%) BMI &gt;25, n (%) 83 (57,2%) 61 (64,9%) 15 (48,4%) 7 (35%) Hypertension, n (%) 46 (31,7%) 28 (29,8%) 13 (41,9%) 5 (25%) Hyperuricemia, n (%) 41 (28,3%) 25 (26,6%) 11 (35,5%) 5 (25%) Diabetes, n (%) 27 (18,6%) 20 (21,3%) 6 (19,4%) 1 (5%) Smokers, n (%) 26 (17,9%) 13 (13,8%) 10 (32,3%) 3 (15%) Depression, n (%) 23 (15,9%) 16 (17%) 6 (19,4%) 1 (5%) Metabolic syndrome n (%) 23 (15,9%) 15 (16%) 5 (16%) 3 (15%) IHD, n (%) 15 (10,3%) 7 (7,4%) 6 (19,4%) 2 (10%) Disclosure of Interests: None declared