THU0142 CHARACTERISTICS OF OSTEOPOROTICAL WOMEN IN A COHORT OF PATIENTS WITH RHEUMATOID ARTHRITIS.
Authors: J. Malave Calzada, I. Braña Abascal, S. M. Rojas Herrera, R. Veroz Gonzalez, M. Priego Fernandez-Martos, D. Fernandez Lozano, M. D. C. Carrasco Cubero, J. J. Aznar Sanchez, L. M. Chaves Chaparro, E. Chamizo Carmona
Journal: Annals of the Rheumatic Diseases (2020)

Background: The estimated prevalece of osteporosis in lumbar spine in women over 50 years is around 22.8% of the general population. In women with rheumatoid arthritis (RA), osteoporosis (OP) is more prevalent and begins at earlier ages. Objectives: The aim of this study is to assess the effect of different risk factors in the development of OP in women with RA. Methods: This is an observational study in women diagnosed of RA according ACR criteria 1987 and 2010, in order to know the influence of different clinical features in the development of OP. Between 2013 and 2109 we offer all women diagnosed of RA to participate in the study and perform an BMD (GE Lunar Prodigy®). SPSS25 was used for statistical analysis. Results: We enrolled 295 women with RA. Mean age 62,4 (± 11,6) years old and average duration of the disease of 118,3 (±98,8) months. Table 1 shows the clinical features of the studied population. BMD was normal in 66 woman (22,4%), therefore 229 (77,6%) y 85 (28,8%) had BMD values less than -1 y -2.5, respectively in femoral neck and/or lumbar spine. Major risk fracture and hip risk fracture (FRAX DMO) was hight in 49,2 y 40,2% of the RA patients, of which almost 15% had a fracture [OR 7,6 (3,1-18,9) p&lt;0,001], mainly women over 50 years old. We found osteoporosis in 85 women, with was associated, in bivariant analysis, at lower heigh, weight, BMI and older age. We didn’t find association with RF, ACPA, smoking, vitamin D deficiency or biological therapy. Corticosteroids were associated with BMD &lt;1 [OR 2.1 (1.2-3.6)] (p = 0.009)], as well as an increased risk of major and hip fracture [OR 4.9 (2, 6-9.4)] (p &lt;0.001)]. Women with a previous fracture were eight times more likely to have a major fracture [OR 7.6 (3.1-18.9) p &lt;0.001] and seven times more than a hip fracture [OR 6.9 (3.1- 15.2) p &lt;0.001] than those without prior fracture. In the adjusted analysis, the OP (femoral neck and/or lumbar spine) was associated with lower weight and age along with the OP emory neck also with the RF level. However, the fracture was mainly related to BMI and OP femoral neck. Table 1. Clinical features Age RA, years (SD) 52,54 (13,21) Height, cm (SD) 153,72 (7,54) Weight, kg (SD) 70,04 (14,39) Smokers, n (%) 33 (11,3) OH-vit D2 &lt;10pg/ml, n (%) 21 (7,8) RF +, n (%) 219 (76,6) ACPA +, n (%) 187 (65,4%) Corticosteroids, n (%) 191 (64,7%) Biologics treatment, n (%) 75 (25,4%) MBD normal 66 (22,4%) MBD lumbar spine CL &lt;-1, n (%) 175 (59,3%) MBD femoral neck &lt;-1, n (%) 192 (65,8%) MBD lumbar spine &lt;-2,5, n (%) 60 (20,5%) MBD femoral neck &lt;-2,5, n (%) 55 (18,8%) Fractures, n (%) 43 (14,7%) Major risk fracture (FRAX), n (%) 125 (49,2%) Femoral head risk fracture (FRAX), n (%) 102 (40,2%) Conclusion: OP and fragility fractures occur earlier and higher in women with RA. BD T-score in femoral neck seems to be the best predictor of fracture. Disclosure of Interests: None declared