tbuckley/cabot-search huggingface dataset:
miR-210 and miR-152 as biomarkers in invasive ductal carcinoma by liquid biopsy
Authors: D.A.P.D.C. Zuccari, B.C. Lopes, F.V. Ventura, J.G. Oliveira, C.Z. Braga, E.M. Kato-Junior, N.A. Bordin-Junior
Journal: Annals of Oncology (2019)

Background: The detection of circulating biomarkers by liquid biopsy is of great importance for early diagnosis and prognosis and, thus, can contribute to decreasing the mortality rate of women with breast cancer (BC). The high mortality of BC is related to the occurrence of metastasis, a process that is associated with angiogenesis. The angiogenic process, in turn, is related to the stimulation of pro-angiogenic factors (among them: Insulin-like Growth Factor 1 Receptor - IGF-1R; Hypoxia-Inducible Factors 1α - HIF-1α and Vascular Endothelial Growth Factor - VEGF) and inhibition of anti-angiogenic factors (such as Von Hippel-Lindau protein - VHL). In addition, the regulation of this neovascularization by epigenetic mechanisms involving microRNAs (miRs) is being investigated and, in BC, oncomiR-210 and the tumor suppressor microRNA-152 stand out in this process. Methods: Plasma samples and tumor fragments were collected from women with BC, with benign breast conditions (BBC) and from healthy women (control). For analysis of microRNA expression, the complementary DNA synthesis was performed followed by real-time Polymerase Chain Reaction (qPCR). For the analysis of the expression of the target proteins, immunohistochemistry was then carried out. Values of p < 0.05 were considered significant. Results: In the plasma samples of women with BC, an increase in the expression of miR-210 and miR-152 was observed. As expected, our results also showed increased oncomiR-210 expression and decreased miR-152 in the fragments of BC. As potential prognostic markers, miR-210 was able to differentiate fragments of BC from good prognosis to poor prognosis. In addition, miR-152 was able to differentiate prognosis in plasma. Finally, it was found that the HIF-1α, IGF-1R and VEGF proteins showed increased expression in BC, whereas the VHL protein presented a decrease. Conclusions: The increased expression of these microRNAs in liquid biopsy of women with BC is promising in the diagnosis and prognosis of this neoplasm, and makes them potential biomarkers for patients with BC. We also confirmed the oncogenic action of miR-210 and tumor suppression of miR-152 on breast cancer fragments validated by the expression of their target proteins. Legal entity responsible for the study: LIMC - Laboratório de Investigação Molecular do Câncer da Faculdade de Medicina de São José do Rio Preto (FAMERP). Funding: Fundação de Amparo a Pesquisa do Estado de São Paulo - FAPESP (Proc. nº 17/11807-3). Disclosure: All authors have declared no conflicts of interest.
DILATION OF THE COMMON BILE DUCT OF INDETERMINATE CAUSE – THE ROLE OF ENDOSCOPIC ULTRASONOGRAPHY
Authors: M Sousa, S Fernandes, L Proença, J Silva, C Gomes, J Carvalho
Journal: Endoscopy (2019)

Dilation of the common bile duct (CBD) of undetermined cause is commonly observed in clinical practice and may have multiple etiologies. The aim of this study was to identify positive endoscopic ultrasonography (EUS) predictors and to assess agreement with magnetic resonance cholangiopancreatography (MRCP).
Photo-triggered gadofullerene: enhanced cancer therapy by combining tumor vascular disruption and stimulation of anti-tumor immune responses
Authors: Mirong Guan, Yue Zhou, Shuai Liu, Daiqin Chen, Jiechao Ge, Ruijun Deng, Xue Li, Tong Yu, Hui Xu, Di Sun, Jiajia Zhao, Toujun Zou, Chunru Wang, Chunying Shu
Journal: Biomaterials (2019)
Longitudinal Changes in Depression Symptoms and Glycemia in Adults With Type 1 Diabetes
Authors: Paula M. Trief, Nicole C. Foster, Naomi Chaytor, Marisa E. Hilliard, Julie M. Kittelsrud, Sarah S. Jaser, Shideh Majidi, Sarah D. Corathers, Suzan Bzdick, Deanna W. Adkins, Ruth S. Weinstock
Journal: Diabetes Care (2019)

OBJECTIVE This study assessed longitudinal change in depression symptoms over ≥4 years in adults with type 1 diabetes and examined the association between change in depression symptom status and glycemia. RESEARCH DESIGN AND METHODS Adults in the T1D Exchange registry with HbA1c and Patient Health Questionnaire (PHQ-8) at 1 year (baseline) and 5 years post-enrollment (follow-up; n = 2,744, mean age, 42 years; 57% female, 92% white; mean HbA1c, 7.6% [58 mmol/mol]) were included. Depression status was defined as Persistent Elevated Depression Symptoms (EDS) (EDS at baseline and follow-up), Resolved EDS (EDS at baseline, no EDS at follow-up), New Onset EDS (no EDS at baseline, EDS at follow-up), and Not Depressed (no EDS at baseline or follow-up). RESULTS Overall, 131 (5%) had Persistent EDS, 122 (4%) had Resolved EDS, 168 (6%) had New Onset EDS, and 2,323 (85%) were Not Depressed. Of those with EDS (PHQ ≥ 10) at baseline, 53% had EDS at follow-up; of those not depressed at baseline, 7% had EDS at follow-up. An increase in PHQ-8 was associated with an increase in HbA1c (P &amp;lt; 0.001). Although HbA1c increased in all groups, the increase was less in the Resolved EDS and Not Depressed groups (P = 0.001). Persistent EDS and New Onset EDS groups were more likely to experience diabetic ketoacidosis (DKA) (P &amp;lt; 0.001). CONCLUSIONS T1D Exchange registry data provide evidence for relationships over time between persistently, and newly developing EDSs and worsening glycemic control, and suggest relationships between depression symptoms and the occurrence of severe hypoglycemia and DKA. Successful treatment of depression symptoms may lead to better long-term diabetes outcomes.
Germline and Somatic Mutations in Prostate Cancer for the Clinician
Authors: Heather H. Cheng, Alexandra O. Sokolova, Edward M. Schaeffer, Eric J. Small, Celestia S. Higano
Journal: Journal of the National Comprehensive Cancer Network (2019)

It is increasingly important for clinicians involved in the management of prostate cancer to understand the relevance of heritable (germline) mutations that, for select patients, affect prostate cancer risk and cancer biology, and acquired (somatic) mutations that occur in prostate cancer cells. In the advanced disease setting, mutations in homologous recombination repair genes (eg, BRCA1 , BRCA2 , ATM , CHEK2 , PALB2 ) suggest candidacy for platinum chemotherapy and PARP inhibitor trials. Similarly, microsatellite instability and mismatch repair deficiency, which may arise in the setting of MLH1 , MSH2 , MSH6 , and PMS2 mutations, suggest potential vulnerability to PD-1 inhibitors. Germline genetic testing has potential importance in the treatment and assessment of familial risk, and tumor-directed somatic sequencing may guide treatment decision-making. This review provides clinicians with knowledge of basic genetic terminology, awareness of the importance of family history of cancer (not limited to prostate cancer), contrasts between the different but potentially related objectives of germline versus somatic testing of tumor tissue, and indications for genetic counseling. Specific clinical scenarios, objectives of testing, and nature of the assays are reviewed. Germline and somatic mutations of known and potential relevance to prostate cancer are discussed in the context of treatment options, and algorithms to assist clinicians in approaching this area are proposed.
Increased risk of breast cancer-specific mortality among women with second primary breast cancer: A SEER population-based study
Authors: C. Wang, K. Hu, H. Zheng, D. Lu
Journal: Annals of Oncology (2019)

Background: With largely improved cancer survivorship in past decades, cancer survivors developed second primary breast cancer (BCa-2) are not uncommon. However, little is known about the prognosis of BCa-2. We therefore aimed to examine the risk of breast cancer-specific mortality among patients with BCa-2 compared with those with first primary breast cancer (BCa-1). Methods: We included all women diagnosed with invasive breast cancer from January 1, 1990 to December 31, 2015 in US who were recorded in the Surveillance, Epidemiology, and End Results (SEER) program. BCa-2 was defined in patients with a previous diagnosis of non-breast primary malignancy in SEER. We estimated the hazard ratios (HRs) of breast cancer-specific and overall mortality among patients with BCa-2 compared with BCa-1, using COX proportional hazard models adjusted for demographic, tumor, and clinical characteristics. Results: 883,881 and 36,313 patients were identified as BCa-1 and BCa-2, respectively. The median intervals from first primary malignancy to BCa-2 diagnosis was 4.75 years. Compared to BCa-1, women with BCa-2 were diagnosed with less aggressive tumor and received less treatment. BCa-2 patients were associated with increased risks of breast cancer-specific mortality (HR: 1.12; 95% CI: 1.08-1.15) and overall mortality (HR: 1.57; 95% CI: 1.54-1.59). The risk increase was particularly greater when the first malignancy was at distant stage, severer in prognosis, diagnosed within 2 years, or treated by chemotherapy/ radiation therapy. Stronger associations were also found among women with HER2 (+), PR (-), ER (-), and those with less aggressive tumor features. Conclusions: Patients with BCa-2 have worse breast cancer-specific survival and overall survival, compared with their BCa-1 counterparts. These findings emphasize the needs for more active treatment and surveillance for cancer survivors who developed BCa-2. Legal entity responsible for the study: West China Hospital, Sichuan University. Funding: National Natural Science Foundation of China (grant number: 81872307), Swedish Research Council (grant number: 2018-00648), and Science and Technology Foundation of Sichuan Province (grant number: 2017SZ0005). Disclosure: All authors have declared no conflicts of interest.
The re-emergence of highly pathogenic avian influenza H7N9 viruses in humans in mainland China, 2019
Authors: Deshan Yu, Guofeng Xiang, Wenfei Zhu, Xia Lei, Baodi Li, Yao Meng, Lei Yang, Hongyan Jiao, Xiyan Li, Weijuan Huang, Hejiang Wei, Yanping Zhang, Yan Hai, Hui Zhang, Hua Yue, Shumei Zou, Xiang Zhao, Chao Li, Deng Ao, Ye Zhang, Minju Tan, Jia Liu, Xuemei Zhang, George F. Gao, Lei Meng, Dayan Wang
Journal: Eurosurveillance (2019)

After no reported human cases of highly pathogenic avian influenza (HPAI) H7N9 for over a year, a case with severe disease occurred in late March 2019. Among HPAI H7N9 viral sequences, those recovered from the case and from environmental samples of a poultry slaughtering stall near their home formed a distinct clade from 2017 viral sequences. Several mutations possibly associated to antigenic drift occurred in the haemagglutinin gene, potentially warranting update of H7N9 vaccine strains.
Acute Kidney Injury Related to Sepsis
Authors: Mark A. Perazella
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Higher relapse rate among HIV/HCV-coinfected patients receiving sofosbuvir/ledipasvir for 8 vs 12 weeks
Authors: Anaïs Corma-Gómez, Juan Macías, Dolores Merino Muñoz, Francisco Téllez, Rafael Granados, Luis E. Morano, Ignacio De Los Santos Gil, Francisco J. Vera-Méndez, Antonio Collado, Rosario Palacios, Juan A. Pineda
Journal: Journal of Infection (2019)
When Can Strut Thickness Really Matter in Percutaneous Coronary Intervention?
Authors: Ajay J. Kirtane, Roxana Mehran
Journal: JAMA Cardiology (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Examining the prior authorization process, patient outcomes, and the impact of a pharmacy intervention: A single-center review
Authors: Sabrina Popatia, Kelsey S. Flood, Nicole M. Golbari, Parth V. Patel, Suzanne M. Olbricht, Alexa B. Kimball, Martina L. Porter
Journal: Journal of the American Academy of Dermatology (2019)
AN UNCOMMON CAUSE OF PERSISTENT DIARRHEA
Authors: JA Cubas, A Maynard, J Dot Bach, M Abu-Suboh Abadia, M Masachs Peracaula, J Armengol Bertroli, J Ramon Armengol Miró
Journal: Endoscopy (2019)

Persistent Diarrhea (duration > 14 days) can have an etiology different than those seen in acute illness. We present the case of a 36-year-old female with no significant medical history. She had traveled 4 weeks prior to Marrakech, Morocco presenting during the trip acute initially non-bloody diarrhea with a low-grade fever then the presence of mucus and bright red blood. On arrival to Spain, she was reviewed by her GP with stool culture and study for parasite done that were negative. A week afterward she presented bilateral conjunctivitis that resolved with symptomatic therapy and 3 days prior to admission presented with pain in her left knee with swelling and lower back pain. She presented to the emergency department where orthopedic surgeon reviewed her knee and performed arthrodesis with the extraction of inflammatory culture and gram-negative fluid without birefringent crystal under the polarized microscope. Laboratory test showed a slight leukocytosis with normal x rays of the lumbosacral region and knee.
ENDOSCOPY IN PREVENTION AND TREATMENT OF ESOPHAGEAL AND GASTRIC VARICEAL BLEEDINGS
Authors: A Filin, V Duvanskiy
Journal: Endoscopy (2019)

Estimate and improve methods of treatment of the patients with esophageal and gastric varices, control of portal bleedings using the method of endoscopic varices ligation (EVL) in esophagus and stomach and the role and limitations of placing of Danish stent.
Diabetes Prevalence by Leisure-, Transportation-, and Occupation-Based Physical Activity Among Racially/Ethnically Diverse U.S. Adults
Authors: Anna A. Divney, Rosenda Murillo, Fatima Rodriguez, Chloe A. Mirzayi, Emma K. Tsui, Sandra E. Echeverria
Journal: Diabetes Care (2019)

OBJECTIVE Leisure-time physical activity (LTPA) has been shown to prevent or delay the development of diabetes. However, little research exists examining how other domains of PA (e.g., occupation based [OPA] and transportation based [TPA]) are associated with diabetes prevalence across diverse racial/ethnic groups. We examined associations between OPA, TPA, and LTPA and diabetes prevalence and whether associations differed by race/ethnicity. RESEARCH DESIGN AND METHODS Participants in the 2011–2016 National Health and Nutrition Examination Survey (NHANES) self-reported domain-specific PA. Diabetes status was determined by self-reported doctor/health professional–diagnosis of diabetes or a glycosylated hemoglobin (HbA1c) measurement of ≥6.5% (48 mmol/mol). Multivariable log binomial models examined differences in diabetes prevalence by PA level in each domain and total PA among Latinos (n = 3,931), non-Latino whites (n = 6,079), and non-Latino blacks (n = 3,659). RESULTS Whites reported the highest prevalence of achieving PA guidelines (64.9%), followed by Latinos (61.6%) and non-Latino blacks (60.9%; P &amp;lt; 0.0009). Participants achieving PA guidelines were 19–32% less likely to have diabetes depending on PA domain in adjusted models. Diabetes prevalence was consistently higher among non-Latino blacks (17.1%) and Latinos (14.1%) compared with non-Latino whites (10.7%; P &amp;lt; 0.0001), but interaction results showed the protective effect of PA was similar across PA domain and race/ethnicity—except within TPA, where the protective effect was 4% greater among non-Latino whites compared with Latinos (adjusted difference in risk differences 0.04, P = 0.01). CONCLUSIONS PA policies and programs, beyond LTPA, can be leveraged to reduce diabetes prevalence among all population groups. Future studies are needed to confirm potentially differential effects of transportation-based active living on diabetes prevalence across race/ethnicity.
Response to: ‘The utility of the HEp-2000 antinuclear antibody substrate’ by Lee<i>et al</i>
Authors: Jan Damoiseaux, Edward K Chan
Journal: Annals of the Rheumatic Diseases (2019)

The correspondence of Lee et al 1 questions why the recent paper2 of the international consensus on ANA patterns (ICAP) consortium about the clinical relevance of HEp-2 indirect immunofluorescent assay (IIFA) patterns does not include the HEp-2000 substrate (Immunoconcepts, Sacramento, California, USA). The decision not to include the HEp-2000 substrate origins from the initial conception of ICAP: it was decided not to include manipulated cellular substrates.3 Since the HEp-2000 cells are transfected with the SS-A/Ro60 cDNA, this substrate was not incorporated in the consensus. Obviously, this decision is disputable and perhaps should be reconsidered in the near future. Indeed, it is to be taken into account that also the ‘non-manipulated’ substrates may be different. First, characteristics of the subcultures may have gradually deviated from the original HEp-2 cells. It is even argued that in time the HEp-2 cells have been contaminated with HeLa-cells.4 Second, diagnostic companies use distinct fixation procedures that eventually also may affect the HEp-2 IIFA patterns. Cell cycle progression can also be manipulated in order …
EARLY GASTRIC CANCERS FREQUENTLY RECUR IN PATIENTS WITH LIVER CIRRHOSIS (LC) COMPARED WITH NON-LC PATIENTS
Authors: MK Joo, CH Yang, JS Koh, BJ Lee, JJ Park, HJ Chun, SW Lee
Journal: Endoscopy (2019)

Aims We investigated clinical efficacy, safety and long-term follow-up outcomes of early gastric cancer (EGC) treated by endoscopic resection in patients with liver cirrhosis (LC), by comparing with non-LC patients.
Aspiration Pneumonia
Authors: Rakan Nasreddine, Nicolas Dauby
Journal: New England Journal of Medicine (2019)

Aspiration PneumoniaTo the Editor: Mandell and Niederman (Feb.14 issue) 1 suggest that for patients with swallowing disorders, particularly after stroke, a mechanical soft diet with thickened liquids may be helpful in the prevention of aspiration pneumonia.An early behavioral intervention by speech and language therapists in patients with acute stroke and swallowing disorders, including dietary modification if it is determined to be appropriate, reduces the risk of chest infections. 2 Although convincing evidence that modified diets prevent pneumonia in adults with chronic dysphagia is lacking, 3 the modification of diets for this purpose has become widespread in recent years.Modified diets worsen quality of life in patients with dysphagia. 4 Thickened liquids are often associated with reduced fluid intake, and texture-modified foods are associated with poorer nutrition in patients with dysphagia.There is limited clinical evidence that the use of more viscous fluids is associated with more prolonged pneumonia, 5 and data from a rabbit model show that aspiration of thickened water is more damaging to the lungs than aspiration of plain water. 6
Feasibility of quantitative sensory testing (QST) in clinical routine as a tool to evaluate chemotherapy-induced peripheral neuropathy (CIPN) amongst breast cancer patients treated with taxanes
Authors: I. Ioannou, D. Utpadel-Fischler, T. Tölle, M. Kiechle, J. Ettl
Journal: Annals of Oncology (2019)

Background: CIPN represents one of the main dose-limiting and quality of life-affecting factors of taxane therapy in breast cancer patients. Effective therapeutic and prophylactic measures against CIPN are still missing. Aim of this study is to develop a tool, which is capable of evaluating CIPN during chemotherapy and to proof its feasibility in clinical routine. Methods: MEDLINE was searched for detection tools of CIPN. Tools were evaluated according to the following criteria: reliability, validity, objectivity, invasiveness, safety, feasibility in clinical routine and clinical significance of the test results. Outcome measures of the modified QST method were: Thermal detection and pain thresholds and the number of paradoxical heat sensations (with TSA-II-NeuroSensory Analyzer), Mechanical detection threshold (with von Frey hairs 0,25-512mN), Mechanical pain threshold (with pin-prick stimulators 8-512 mN) and Vibration detection threshold (with Rydel–Seiffer graded tuning fork 64 Hz). Ten breast cancer patients under taxane containing chemotherapy were evaluated via the modified QST-Measurement. All patients suffered from CIPN symptoms and had decreased scores in the FACT/GOG-NTx questionnaire. Results: 21 detection tools were identified and evaluated. QST was chosen for conducting the feasibility study. All study patients completed the QST-measurement and were evaluable. QST detected abnormal Z-Values in nine out of ten symptomatic patients (Table).Table217P QST-resultsPat.Nr.CDTWDTTSLCPTHPTMPTMDTVDTPHSHFHFHFHFHFHFHFHFHF1––––––23––––––1/34–––5+–6++1/37+––––8–––––++––––1/39––––––3/310++–2/3H: hand, F:foot, -/ + = values lower/upper from normal z-values, CDT=cold detection threshold, WDT=warm detection threshold, TSL=thermal sensory limen, CPT=cold pain threshold, HPT=heat pain threshold, MPT=mechanical pain threshold, MDT=mechanical detection threshold, VDT=vibration detection threshold, PHS=paradoxical heat sensations. Open table in a new tab H: hand, F:foot, -/ + = values lower/upper from normal z-values, CDT=cold detection threshold, WDT=warm detection threshold, TSL=thermal sensory limen, CPT=cold pain threshold, HPT=heat pain threshold, MPT=mechanical pain threshold, MDT=mechanical detection threshold, VDT=vibration detection threshold, PHS=paradoxical heat sensations. Conclusions: QST is feasible to evaluate CIPN in clinical routine. The modified QST method can be used to evaluate CIPN in breast cancer patients who undergo taxane therapy. Legal entity responsible for the study: Klinikum Rechts der Isar, Technische Universität München, Dr. med. Johannes Ettl. Funding: Celgene. Disclosure: All authors have declared no conflicts of interest.