tbuckley/cabot-search huggingface dataset:
Reduced Lung-Cancer Mortality with Volume CT Screening in a Randomized Trial
Authors: Harry J. de Koning, Carlijn M. van der Aalst, Pim A. de Jong, Ernst T. Scholten, Kristiaan Nackaerts, Marjolein A. Heuvelmans, Jan-Willem J. Lammers, Carla Weenink, Uraujh Yousaf-Khan, Nanda Horeweg, Susan van ’t Westeinde, Mathias Prokop, Willem P. Mali, Firdaus A.A. Mohamed Hoesein, Peter M.A. van Ooijen, Joachim G.J.V. Aerts, Michael A. den Bakker, Erik Thunnissen, Johny Verschakelen, Rozemarijn Vliegenthart, Joan E. Walter, Kevin ten Haaf, Harry J.M. Groen, Matthijs Oudkerk
Journal: New England Journal of Medicine (2020)

There are limited data from randomized trials regarding whether volume-based, low-dose computed tomographic (CT) screening can reduce lung-cancer mortality among male former and current smokers.
Practical Guide to Survey Research
Authors: Karen Brasel, Adil Haider, Jason Haukoos
Journal: JAMA Surgery (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Ropeginterferon alfa-2b versus standard therapy for polycythaemia vera (PROUD-PV and CONTINUATION-PV): a randomised, non-inferiority, phase 3 trial and its extension study
Authors: Heinz Gisslinger, Christoph Klade, Pencho Georgiev, Dorota Krochmalczyk, Liana Gercheva-Kyuchukova, Miklos Egyed, Viktor Rossiev, Petr Dulicek, Arpad Illes, Halyna Pylypenko, Lylia Sivcheva, Jiri Mayer, Vera Yablokova, Kurt Krejcy, Barbara Grohmann-Izay, Hans C Hasselbalch, Robert Kralovics, Jean-Jacques Kiladjian, Franz Bauer, Nicoleta Berbec, Carlos Besses Raebel, Zita Borbenyi, Horia Bumbea, Veronika Buxhofer-Ausch, Malgorzata Calbecka, Emilie Cayssials-Caylus, Mario Cazzola, Olga Cerna, Andrei Cucuianu, Delia Monica Dima, Ernst Forjan, Emanuil Gheorghita, Richard Greil, Antonia Hatalova, Mikulas Hrubisko, Janos Jakucs, Polina Kaplan, Sergiy Klymenko, Steffen Koschmieder, Mihaela Lazaroiu, Tamila Lysa, Zvenyslava Masliak, Tamas Masszi, Georgi Mihaylov, Alexander Myasnikov, Uwe Platzbecker, Mathieu Puyade, Jerome Rey, Lydia Roy, Jiri Schwarz, Aleksander Skotnicki, Irina Sokolova, Maria Soroka-Wojtaszko, Jolanta Starzak-Gwozdz, Vera Stoeva, Jose Miguel Torregrosa-Diaz, Anna Vallova, Elena Volodicheva, Krzysztof Warzocha, Ella Willenbacher, Dominik Wolf
Journal: The Lancet Haematology (2020)
Jointly Inferring the Dynamics of Population Size and Sampling Intensity from Molecular Sequences
Authors: Kris V Parag, Louis du Plessis, Oliver G Pybus
Journal: Molecular Biology and Evolution (2020)

Abstract Estimating past population dynamics from molecular sequences that have been sampled longitudinally through time is an important problem in infectious disease epidemiology, molecular ecology, and macroevolution. Popular solutions, such as the skyline and skygrid methods, infer past effective population sizes from the coalescent event times of phylogenies reconstructed from sampled sequences but assume that sequence sampling times are uninformative about population size changes. Recent work has started to question this assumption by exploring how sampling time information can aid coalescent inference. Here, we develop, investigate, and implement a new skyline method, termed the epoch sampling skyline plot (ESP), to jointly estimate the dynamics of population size and sampling rate through time. The ESP is inspired by real-world data collection practices and comprises a flexible model in which the sequence sampling rate is proportional to the population size within an epoch but can change discontinuously between epochs. We show that the ESP is accurate under several realistic sampling protocols and we prove analytically that it can at least double the best precision achievable by standard approaches. We generalize the ESP to incorporate phylogenetic uncertainty in a new Bayesian package (BESP) in BEAST2. We re-examine two well-studied empirical data sets from virus epidemiology and molecular evolution and find that the BESP improves upon previous coalescent estimators and generates new, biologically useful insights into the sampling protocols underpinning these data sets. Sequence sampling times provide a rich source of information for coalescent inference that will become increasingly important as sequence collection intensifies and becomes more formalized.
Resveratrol downregulates cIAP-1 expression and enhances death receptor-mediated apoptosis of prostate cancer cells
Authors: Catherine Gill, Sinead Walsh, Colm Morrissey, John Fitzpatrick, William G. Watson
Journal: Cancer Research (2006)

785  The inhibitor of apoptosis protein (IAP) survivin is highly expressed in melanomas compared to normal melanocytes, and confers apoptosis protection in these tumors. Given the association of survivin expression with activation (tyrosine phosphorylation) of the transcription factor Signal Transducer and Activator of Transcription (Stat)3 in various tumor cell lines, we sought to investigate whether survivin expression was directly controlled by stat factors in melanoma cell lines. We detected high levels of phospho-Stat3 by Western blotting in survivin-expressing human melanoma lines YUSAC2 and YUGEN8, while low levels were detected in melanocytes. By comparison, these cell lines expressed low levels of phospho-Stat5 whereas phospho-Stat1 was undetectable. DNA-binding assays (EMSAs) using probes containing Stat1, Stat3, and Stat5 consensus binding sites confirmed high Stat3 DNA-binding activity in nuclear extracts, whereas Stat1 and Stat3 binding activity was not detected. Transient transfection assays using deletion fragments of the survivin promoter fused to a luciferase reporter construct identified the active region of the promoter to be within 1.4 kb upstream of the translational start site. Within this region, we identified two putative Stat-binding sites using MatInspector (http://www.genomatix.de/products/MatInspector/index.html), at positions -255 and -714. Treatment of YUSAC2 and YUGEN8 cells with the specific JAK-Stat inhibitor AG490 lowered survivin levels in 24 hours, and caused significant apoptosis in 48-72 hours, suggesting that survivin upregulation by a Stat family member maintained apoptosis protection in these cells. EMSAs using labeled probes containing the putative Stat-binding sites of the survivin promoter were gel-shifted by nuclear extracts isolated from YUSAC2 and YUGEN8 cells. However, only the probe containing the -714 site was successfully competed by 100-fold excess of unlabeled probe, but not by similar excess of probe mutated at the putative Stat-binding sites, suggesting the specific binding of a Stat family factor at position -714. This gel-shift was not altered by addition of antibodies to Stat3, phospho-Stat3 or Stat5, although interestingly was disrupted by antibody to phospho-Stat5 (which may be binding to a related Stat factor). These results suggest that a Stat family member binds to the survivin promoter at -714 and promotes survivin expression in these melanoma lines. Thus survivin upregulation, which is vital for apoptosis protection, may take place via a novel transcriptional mechanism in melanoma cells.
Abstract 227: Single-blind Study of Q-sweat in Postural Orthostatic Tachycardia Syndrome (POTS)
Authors: Muhammad M Ahsan, Tara Thompson, Chandralekha Ashangari, Amer Suleman
Journal: Circulation Research (2016)

Background: Postural Orthostatic Tachycardia Syndrome (POTS) is a form of dysautonomia that is estimated to impact between 1,000,000 and 3,000,000 Americans and millions more around the world. Symptoms often include orthostatic intolerance such as dizziness, fatigue, excessive sweating and many others. The aim of this study is to determine the Q-sweat study in POTS patients. Methods: This study was a randomized, single-blind study. Patients evaluated between October 2014 to June 2015 were included. The skin on the leg and wrist is wiped with acetone, then alcohol and dried, cleaning the skin in preparation for the test. Four electrodes filled with acetylcholine are placed on three areas of the leg and one area on the wrist. A mild electrical current called iontophoresis is then applied to help the drug stimulate the sweat glands. This evokes sweating at the site, but it also allows the body to release its own acetylcholine, resulting in sweat production at nearby sites. After a stimulus (e.g. a deep breath) any deviation from the baseline is reported. If no change is seen, a stronger stimulus is applied (e.g. electrical stimulation) and if there is still no change seen, an “absent response” is reported. The onset latency and magnitude of response can be quantified, although the results are highly variable within and between subjects. The sweat response is measured Q-sweat recordings of Left proximal leg, Left distal leg and Left foot sites were analyzed. Results are categorized as Normal response, no response, hung up and prolong response. Results: A total 144 POTS patients were included, Out of 144 POTS patients 88% are females (n=127, mean age 31.93±12.37) and 12% are males (n=17, mean age 31.59±11.14), Left proximal leg site 69/144(48%) Patients had hung up, 8/144(6%) had No response, 29/144(20%) had Normal, 38/144(26%) had Prolong. Left distal leg site 72/144(50%) had hung up, 13/144(9%) had No response, 23/144(16%) had Normal, 36/144(25%) had Prolong. Left foot site 36/144(25%) had hung up, 35/144(24%) had No response, 40/144(28%) had Normal, 33/144(23%) had Prolong response. Conclusion: Postural Orthostatic Tachycardia Syndrome had a higher percentage of patients with Hung up response.
Abstract 15901: 17β-Estradiol and Its Receptor ERα Protect Against Right Ventricular Vascular Rarefaction and Endothelial Cell Dysfunction in Experimental Pulmonary Hypertension
Authors: Andrea L Frump, Marjorie Albrecht, Bakhtiyor Yakubov, Tim Lahm
Journal: Circulation (2018)

Introduction: Women with pulmonary arterial hypertension (PAH) exhibit better right ventricular (RV) function and survival than men; however, the mechanisms underlying this survival advantage are u...
J774マクロファージ及びFu5AH肝癌細胞からCETP欠乏症由来血清へのコレステロール流出の増強 | 文献情報 | J-GLOBAL 科学技術総合リンクセンター
Authors: Miwa K, Inazu A, Takata M, Katsuda S, Kawashiri M, Nohara A, Higashikata T, Kobayashi J, Shimizu M
Journal: Circulation (2005)
チック,性癖障害と吃音の習慣反転治療の効力:メタ分析的総説 | 文献情報 | J-GLOBAL 科学技術総合リンクセンター
Authors: S Bate Karina, M Malouff John, T Thorsteinsson Einar, Bhullar Navjot
Journal: Clinical Psychology Review (2011)
Abstract 13422: Associations of Circulating Trimethylamine-n-Oxide (TMAO) With Dietary Intakes and Cardiometabolic Biomarkers: Results From the TMAO Pooling Project
Authors: Jae Jeong Yang, Xiao-Ou Shu, David M Herrington, Steven C Moore, Katie A Meyer, Jennifer Ose, Cristina Menni, Nicholette D Palmer, Wei Zheng, Sei Harada, Huilian Zhu, Demetrius Albanes, Thomas J Wang, Cornelia M Ulrich, Myriam Fornage, Qiuyin Cai, Charles E Mattews, Fang-Chi Hsu, Yong-Bing Xiang, Robert E Gerszten, Hui Cai, Danxia Yu
Journal: Circulation (2019)

Background: Trimethylamine-N-oxide (TMAO), a diet-derived, gut microbial-host co-metabolite, has been linked to cardiovascular disease (CVD). Population-based, multi-ethnic studies on the associati...
Zwitterionic Polymer Coating of Sulfur Dioxide‐Releasing Nanosystem Augments Tumor Accumulation and Treatment Efficacy
Authors: Xianxian Yao, Shuangping Ma, Shaojun Peng, Gaoxin Zhou, Ruihong Xie, Qin Jiang, Shengdi Guo, Qianjun He, Wuli Yang
Journal: Advanced Healthcare Materials (2020)

Abstract Multiple drug resistance (MDR) exhibited by cancer cells and low intratumor accumulation of chemotherapeutics are the main obstacles in cancer chemotherapy. Herein, the preparation of a redox‐responsive sulfur dioxide (SO 2 )‐releasing nanosystem, with high SO 2 ‐loading capacity, aimed at improving the treatment efficacy of cancers exhibiting MDR is described. The multifunctional nanomedicine (MON‐DN@PCBMA‐DOX) is designed and constructed by coating mesoporous organosilica nanoparticles with a zwitterionic polymer, poly(carboxybetaine methacrylate) (PCBMA), which can concurrently load SO 2 prodrug molecules (DN, 2,4‐dinitrobenzenesulfonylchloride) and chemotherapeutics (DOX, doxorubicin). The generated SO 2 molecules can sensitize cells to chemotherapy and overcome the MDR by downregulating the expression of P‐glycoprotein. Furthermore, the PCBMA coating prolongs the blood circulation time of the inner core, leading to an increased intratumor accumulation of the nanomedicine. Owing to the prolonged blood circulation, enhanced tumor accumulation, and SO 2 sensitization of cells to chemotherapy, the nanomedicine exhibits excellent tumor suppression with a tumor inhibition rate of 94.8%, and might provide a new platform for cancer therapy.
Integration of Psychosocial Care into Routine Cancer Care: Final Results of A Large Collaborative, Hospital-Based, Quality Improvement Study (Hucare Project)
Authors: R. Passalacqua, C. Caminiti, M.A. Annunziata, C. Borreani, J. Saleri, F. Diodati, L. Isa, S. Filiberti, D. Fagnani, G. Donati
Journal: Annals of Oncology (2012)
線維芽細胞特異的タンパク1/S100A4陽性細胞は,発がん物質のコラーゲン生成およびカプセル化を通じて癌を予防する
Authors: Zhang Jinhua, Chen Lin, Liu Xiaoman, Kammertoens Thomas, Blankenstein Thomas, Qin Zhihai
Journal: Cancer Research (2013)
コレステロールの合成と吸収のマーカーに関連した脂質低下に対するスタチン単独療法とエゼチミベ-スタチン療法の効果 | 文献情報 | J-GLOBAL 科学技術総合リンクセンター
Authors: Fukuoka Taku, Kanna Masahiko, Yano Hideto, Yotukura Hiroko, Takamizawa Tetsu, Arakawa Kentaro, Himeno Hideo, Uchino Kazuaki, Endo Tsutomu, Kobayashi Shunichi, Morita Yukiko, Shigemasa Tomohiko, Sawada Reimin, Kimura Kazuo, Umemura Satoshi
Journal: Circulation (2010)
Should oral anticoagulation be discontinued after 3 months in the setting of a first high-risk pulmonary embolism secondary to a major transient/reversible risk factor?
Authors: Guy Meyer, Stavros Konstantinides
Journal: European Respiratory Journal (2020)

<b>For patients with first pulmonary embolism secondary to a major transient/reversible risk factor, discontinuation of therapeutic oral anticoagulation is recommended after 3 months</b>http://bit.ly/2Pp68Ti
Martin Peter Ward Platt
Authors: Alan Fenton, Peter Fleming, Nick Brown
Journal: BMJ (2020)

After attending Oundle school, Martin Peter Ward Platt studied medicine at Bristol University, where he met his future wife, Anne. He became interested in paediatrics while a student and did senior house officer posts in paediatrics in Bristol, as well as a year in pathology. It was during the latter post that he started his lifelong interest in perinatal morbidity and mortality and indeed research in general. A move to the north east followed, and it was here he remained for the rest of his career. Alongside his clinical training, which included a neonatal fellowship spell at Monash Medical Centre in Melbourne, Australia, he held an Action Research training fellowship, investigating the metabolic and endocrine responses of children to surgery, which led to his MD. On completing his training in 1990 he was appointed as a consultant to the neonatal unit at the Princess Mary Maternity Hospital until the two maternity services in Newcastle were amalgamated on the Royal Victoria Infirmary site in 1993.

Martin was not simply a neonatologist: his interests spanned all aspects of child health, from teaching and training to service delivery, public health, and research. To all of these he brought a truly unique style and had an extraordinary ability to communicate any concept, however …
Concerns About the HCM Risk-Kids Study
Authors: Ingegerd Östman-Smith, Davood Javidgonbadi, Eva Fernlund
Journal: JAMA Cardiology (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
MiR-30e-3p Influences Tumor Phenotype through <i>MDM2</i>/<i>TP53</i> Axis and Predicts Sorafenib Resistance in Hepatocellular Carcinoma
Authors: Laura Gramantieri, Daniela Pollutri, Martina Gagliardi, Catia Giovannini, Santina Quarta, Manuela Ferracin, Andrea Casadei-Gardini, Elisa Callegari, Sabrina De Carolis, Sara Marinelli, Francesca Benevento, Francesco Vasuri, Matteo Ravaioli, Matteo Cescon, Fabio Piscaglia, Massimo Negrini, Luigi Bolondi, Francesca Fornari
Journal: Cancer Research (2020)

Abstract The molecular background of hepatocellular carcinoma (HCC) is highly heterogeneous, and biomarkers predicting response to treatments are an unmet clinical need. We investigated miR-30e-3p contribution to HCC phenotype and response to sorafenib, as well as the mutual modulation of TP53/MDM2 pathway, in HCC tissues and preclinical models. MiR-30e-3p was downregulated in human and rat HCCs, and its downregulation associated with TP53 mutations. TP53 contributed to miR-30e-3p biogenesis, and MDM2 was identified among its target genes, establishing an miR-30e-3p/TP53/MDM2 feedforward loop and accounting for miR-30e-3p dual role based on TP53 status. EpCAM, PTEN, and p27 were demonstrated as miR-30e-3p additional targets mediating its contribution to stemness and malignant features. In a preliminary cohort of patients with HCC treated with sorafenib, increased miR-30e-3p circulating levels predicted the development of resistance. In conclusion, molecular background dictates miR-30e-3p dual behavior in HCC. Mdm2 targeting plays a predominant tumor suppressor function in wild-type TP53 contexts, whereas other targets such as PTEN, p27, and EpCAM gain relevance and mediate miR-30e-3p oncogenic role in nonfunctional TP53 backgrounds. Increased circulating levels of miR-30e-3p predict the development of sorafenib resistance in a preliminary series of patients with HCC and deserve future investigations. Significance: The dual role of miR-30e-3p in HCC clarifies how the molecular context dictates the tumor suppressor or oncogenic function played by miRNAs.
Targeting cancer cells with nanotherapeutics and nanodiagnostics: Current status and future perspectives
Authors: Eunus S. Ali, Shazid Md. Sharker, Muhammad Torequl Islam, Ishaq N. Khan, Subrata Shaw, Md. Atiqur Rahman, Shaikh Jamal Uddin, Manik Chandra Shill, Shahnawaz Rehman, Niranjan Das, Saheem Ahmad, Jamil A. Shilpi, Swati Tripathi, Siddhartha Kumar Mishra, Mohammad S. Mubarak
Journal: Seminars in Cancer Biology (2020)
Forty-five per cent lower acute injury incidence but no effect on overuse injury prevalence in youth floorball players (aged 12–17 years) who used an injury prevention exercise programme: two-armed parallel-group cluster randomised controlled trial
Authors: Ida Åkerlund, Markus Waldén, Sofi Sonesson, Martin Hägglund
Journal: British Journal of Sports Medicine (2020)

Objective To study whether an injury prevention exercise programme would reduce the number of injuries in youth floorball players. Methods 81 youth community level floorball teams (48 clusters=clubs) with female and male players (12–17 years) were cluster-randomised into an intervention or control group. Intervention group coaches were instructed to use the Swedish Knee Control programme and a standard running warm-up before every training session, and the running warm-up before every match, during the season. Control teams continued usual training. Teams were followed during the 2017/2018 competitive season (26 weeks). Player exposure to floorball and occurrence of acute and overuse injuries were reported weekly via a web-based player survey using the Oslo Sports Trauma Research Centre Questionnaire. Results 17 clusters (301 players) in the intervention group and 12 clusters (170 players) in the control group were included for analyses. There were 349 unique injuries in 222 players. The intervention group had a 35% lower incidence of injuries overall than the control group (adjusted incidence rate ratio (IRR) 0.65, 95% CI 0.52 to 0.81). The absolute risk reduction was 6.6% (95% CI 3.2 to 10.0), and the number needed to treat was 152 hours of floorball exposure (95% CI 100 to 316). Intervention group teams had a 45% lower incidence of acute injuries (adjusted IRR 0.55, 95% CI 0.37 to 0.83). There was no difference in the prevalence of overuse injuries (adjusted prevalence rate ratio 0.96, 95% CI 0.73 to 1.26). Conclusion The Knee Control injury prevention programme reduced acute injuries in youth floorball players; there was no effect on overuse injuries. Trial registration number Clinical Trials NCT03309904 .
A mouse model of MSU-induced acute inflammation <i>in vivo</i> suggests imiquimod-dependent targeting of <i>Il-1β</i> as relevant therapy for gout patients
Authors: Alexandre Mariotte, Aurore De Cauwer, Chrystelle Po, Chérine Abou-Faycal, Angélique Pichot, Nicodème Paul, Ismael Aouadi, Raphael Carapito, Benoit Frisch, Cécile Macquin, Emmanuel Chatelus, Jean Sibilia, Jean-Paul Armspach, Seiamak Bahram, Philippe Georgel
Journal: Theranostics (2020)

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