AB0553 Characteristics of systemic lupus erythematosus among various age groups: comparison between juvenile onset, adult onset, and late onset systemic lupus patients from a single tertiary centrein egypt
Authors: B.M. Medhat, N. Sobhy, B. Eissa
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Systemic lupus erythematosus (SLE) is a complex autoimmune disease with several factors affecting the characteristics of the disease, including age of onset which is one of these major factors.<sup>1</sup> <h3>Objectives</h3> To highlight the differences in disease characteristics among various age groups in an Egyptian cohort from a single tertiary centre. <h3>Methods</h3> Information in this study was derived from medical records of patients admitted to the Rheumatology department in Cairo University from December 2015 to June 2017. All patients fullfilled the SLICC classification criteria of 2012.<sup>2</sup> Demographic, clinical and serologic characteristics of all patients were recorded. Age of onset was defined as the age at the time of development of manifestations; upon which patients were divided into 3 groups: juvenile onset (JSLE: onset ≤16 years), adult onset: (ASLE: onset 17–50), and late onset lupus (LSLE: onset &gt;50) patients. <h3>Results</h3> The study included 369 patients, of which 44 (11.96%) were males and 324 (88.04%) were females. The mean age of onset of the cohort was 24.04±10.15 (7–63) years, while the mean disease duration was 65.6±58.4 (0.5–408) months. The study included 75/369 (20.3%) JSLE, 283/369 (76.6%) ASLE, and 10/369 (2.7%) LSLE patients. The median age of onset of JSLE patients was 13 (11–15), 23 (20–30) in ASLE patients, and 54 (52–58) years in the LSLE group. The median disease duration in JSLE patients was 78 (36–125), 36 (24–84) in ASLE patients, and 12 (9–38) months in LSLE patients. Apart from arthritis, malar rash, and nephritis, there were no differences between the three groups. The prevalence of arthritis was highest among ASLE patients and lowest in JSLE (p=0.004) patients, with LSLE patients showing a comparable prevalence of arthritis to ASLE (p=0.5) and JSLE (p=0.3) patients. On the other hand, JSLE patients showed the highest prevalence of malar rash (p=0.006), as opposed to both ASLE (p=0.04) and LSLE (p=0.004) patients; yet ASLE patients showed a substantially high prevalence of malar rash when compared to LSLE patients (p=0.03). Nephritis was most common in JSLE patients (p=0.007) and least common in LSLE patients. Although there was no statistical difference in the prevalence of nephritis between JSLE and ASLE patients (p=0.1), both groups showed a higher prevalence of nephritis than LSLE patients (p=0.002 and p=0.01 respectively). <h3>Conclusions</h3> Adult onset SLE patients showed the highest prevalence of arthritis. On the other hand, JSLE patients showed the highest prevalence of nephritis as opposed to LSLE patients with the lowest prevalence, indicating a predilection towards a more severe disease in the former group. <h3>References</h3> [1] Tucker LB, Uribe AG, Fernández M, et al. Adolescent onset of lupus results in more aggressive disease and worse outcomes:Results of a nested matched case-control study within LUMINA,a multiethnic US cohort (LUMINA LVII). Lupus2008; 17:314–322.17 [2 ] Petri M, Orbai AM, Alarcón GS, et al. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis &amp; Rheumatology2012;64:2677–86. <h3>Disclosure of Interest</h3> None declared