tbuckley/cabot-search huggingface dataset:
Association of Demographic and Program Factors With American Board of Surgery Qualifying and Certifying Examinations Pass Rates
Authors: Heather L. Yeo, Patrick T. Dolan, Jialin Mao, Julie A. Sosa
Journal: JAMA Surgery (2019)

American Board of Surgery board certification requires passing both a written qualifying examination and an oral certifying examination. No studies have been conducted assessing the effect of sociodemographic variables on board passage rates.To evaluate if trainee sociodemographic factors are associated with board passage rates.This national and multi-institutional prospective observational cohort study of 1048 categorical general surgery trainees starting in 2007-2008 were surveyed. Data collection began in June 2007, follow-up was completed on December 31, 2016, and analysis began September 2018.Survey responses were linked to American Board of Surgery board passage data.Of 662 examinees who had complete survey and follow-up data, 443 (65%) were men and 459 (69%) were white, with an overall board passage rate of 87% (n = 578). In a multinomial regression model, trainees of Hispanic ethnicity were more likely to not attempt the examinations (vs passed both) than non-Hispanic trainees (odds ratio [OR], 4.7; 95% CI, 1.5-14). Compared with examinees who were married with children during internship, examinees who were married without children (OR, 0.3; 95% CI, 0.1-0.8) or were single (OR, 0.4; 95% CI, 0.2-0.9) were less likely to fail the examinations. Logistic regression showed white examinees compared with nonwhite examinees (black individuals, Asian individuals, and individuals of other races) (OR, 1.8; 95% CI, 1.03-3.0) and examinees who performed better on their first American Board of Surgery In-Training Examination (OR, 1.03; 95% CI, 1.02-1.05) were more likely to pass the qualifying examination on the first try. White examinees compared with nonwhite examinees (OR, 1.8; 95% CI, 1.1-2.8), non-Hispanic compared with Hispanic examinees (OR, 2.4; 95% CI, 1.2-4.7), and single women compared with women who were married with children during internship (OR, 10.3; 95% CI, 2.1-51) were more likely to pass the certifying examination on the first try.Resident race, ethnicity, sex, and family status at internship were observed to be associated with board passage rates. There are multiple possible explanations for these worrisome observations that need to be explored. Tracking demographics of trainees to help understand passage rates based on demographics will be important. The American Board of Surgery already has begun addressing the potential for unconscious bias among board examiners by increasing diversity and adding implicit bias training.
Challenges of Dual-Physician Couples—Reply
Authors: Lauren Ferrante, Lona Mody
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CEBPα Is a Transcriptional Repressor of T-Cell Related Genes Explaining the Myeloid/T-Lymphoid Features of CEBPα-Silenced AML
Authors: Erdogan Taskesen, Roberto Avellino, Meritxell AlberichJorda, Daniel G. Tenen, Jeroen Ridder de, Peter Valk, Bas Wouters, Claudia Erpelinck, Marcel Reinders, Ruud Delwel
Journal: Blood (2011)
The association of cardiovascular failure with treatment for ventilator-associated lower respiratory tract infection
Authors: Ignacio Martin-Loeches, Antoni Torres, Pedro Povoa, Fernando G. Zampieri, Jorge Salluh, Saad Nseir, Miquel Ferrer, Alejandro Rodriguez, I. Martin-Loeches, P. Povoa, Fernando Zampieri, Jorge Salluh, Saad Nseir, A. Rodríguez, D. Curcio, J. P. Mira, M. L. Cordero, R. Lepecq, C. Girault, C. Candeias, P. Seguin, C. Paulino, J. Messika, A. G. Castro, L. Coelho, L. Rabello, T. Lisboa, A. Torres, J. Salluh, S. Nseir, R. O. Fernández, J. Arroyo, M. Gabriela, R. Alvarez, A. T. Reyes, C. Dellera, F. Molina, D. M. Franco, E. G. Parada, E. S. Yepez, F. P. Oña, D. M. Tutillo, D. Barahona, F. A. Lerma, A. A. Álvarez, J. M. Gallego, F. J. Morillas, A. L. Aguilar, M. L. Lorenzana, R. S. Iniesta, J. Almirall, A. Albaya, S. R. Santana, C. Fernandez, M. A. Potro, P. V. Cortes, B. Jimenez, R. Sierra, M. Del Valle Ortiz, N. Cruza, P. M. Olaechea, A. C. Zirena, P. P. Gonzalez, T. R. Gomez, L. S. Crespi, P. R. Galleymore, R. J. Marcos, C. Palazón, B. G. Rueda, J. C. Ballesteros, M. P. Arnilla, A. Socias, J. Amador, E. M. Silvero, L. M. Redín, M. Z. Elson, L. C. Pericas, J. Á. Rodríguez, M. Nieto, A. Torres, E. Molinos, A. Josefi, N. Catorze, P. Póvoa, C. Candeias, L. Coelho, P. André, M. Ángel, G. García, C. S. Ramirez, M. Calizaya, A. Estella, A. Albis, G. Aguilar, E. Torrents, M. G. Puente, A. G. Sanchez, T. Lisboa, P. Azambuja, M. F. Knibel, O. Ranzani, L. D. Camargo, A. P. Junior, C. B. Ferreira, S. Lobo, L. Rabello, M. Park, A. G. de Carvalho, M. Valencia, A. G. Castro, A. A. López, J. M. Caballero, S. Nseir, K. Jaffal, E. Parmentier-Decrucq, S. Préau, C. Rousselin, C. Blazejewski, J. Masse, L. Robriquet, L. Satre-Buisson, J. P. Mira, N. Martin, R. Lepecq, H. Mentec, C. Girault, A. Marchalot, J. Messika, J. D. Ricard, P. Seguin, B. Mégarbane, S. Valade, E. Azoulay, N. Boussekey, O. Leroy, J. Reignier, M. Clavel, N. Pichon, T. Baudry, L. Argaud, P. Beuret, A. A. Hssain, M. Nyunga, I. Alves, F. Dewavrin, G. Brunin, S. Mérat, P. Pasquier, F. Brun, A. Palud, B. Voisin, R. Grenot, N. Van Grunderbeeck, D. Thévenin, B. Misset, F. Philippart, J. P. Frat, R. Coudroy, P. Cabaret, M. Ledein, F. Z. Slimane, R. Miguel-Montanes, N. Weiss, F. Bolgert, B. Just
Journal: Intensive Care Medicine (2019)
Sequential Treatment with FLAG-IDA Salvage Chemotherapy Followed By Allogeneic Hematopoietic Cell Transplantation in Patients with Relapsed/Refractory Acute Leukemia
Authors: Liat Shargian-Alon, Ofir Wolach, Oren Pasvolsky, Pia Raanani, Moshe Yeshurun
Journal: Blood (2018)
Vemurafenib Plus Rituximab in Hairy Cell Leukemia: A Promising Chemotherapy-Free Regimen for Relapsed or Refractory Patients
Authors: Enrico Tiacci, Luca De Carolis, Francesco Zaja, Achille Ambrosetti, Eugenio Lucia, Agostino Antolino, Alessandro Pulsoni, Samantha Ferrari, Pier Luigi Zinzani, Gianluca Gaidano, Robin Foà, Brunangelo Falini
Journal: Blood (2016)
Prognostic Significance of Tracking Dynamic Changes in Positron Emission Tomography (PET) Scan Pre and Post Autologous Stem Cell Transplant (ASCT)
Authors: Shebli Atrash, Myra M Robinson, Manisha Bhutani, Daniel Slaughter, Issam S. Hamadeh, Peter M. Voorhees, Jill Eddy, Lauren Minard, Reed Freind, Jordan Robinson, NDaiye AMI, Chelsea Sprouse, James Symanowski, Maham Khan, Belinda Rene Avalos, Rajesh Banderudrappagari, Justin Arnall, Edward A. Copelan, Saad Z. Usmani
Journal: Blood (2018)
Recurrence of Device-Related Thrombus After Percutaneous Left Atrial Appendage Closure
Authors: Lluis Asmarats, Ignacio Cruz-González, Luis Nombela-Franco, Dabit Arzamendi, Vicente Peral, Fabian Nietlispach, Azeem Latib, Diego Maffeo, Rocío González-Ferreiro, Tania Rodríguez-Gabella, Victor Agudelo, Marta Alamar, Raffael A. Ghenzi, Antonio Mangieri, Mathieu Bernier, Josep Rodés-Cabau
Journal: Circulation (2019)
Pharmacologic Blockade of Notch/Delta-like Ligand 4 Signaling Protects from Gastrointestinal Acute Graft-Versus-Host Disease in Non-Human Primates
Authors: Victor Tkachev, Frank Kuhnert, Scott N Furlan, Hengqi Zheng, Daniel J Hunt, Lucrezia Colonna, Judith M Carlson, Agne Taraseviciute, Angela Panoskaltsis-Mortari, Virginia Hoglund, Kayla Betz, Alison Yu, Bruce R. Blazar, Steve Carpenter, Olivier Harari, Gavin Thurston, Ivan Maillard, Leslie Kean
Journal: Blood (2018)
Response to Comment on Riddle et al. <i>Diabetes Care</i> Editors’ Expert Forum 2018: Managing Big Data for Diabetes Research and Care. Diabetes Care 2019;42:1136–1146
Authors: Matthew C. Riddle, William T. Cefalu, Edward W. Gregg
Journal: Diabetes Care (2019)

Hall et al. (1) write concerning our summary of the future potential and current limitations of analyses based on big data in populations of people with diabetes, published as the proceedings of an Expert Forum (2). They commented specifically on three aspects of this question.

They call attention to collection of data from reimbursement claims and newer sources such as physiologic measurements obtained by personal devices used or worn by individual patients. We briefly referred to these sources of information in our article, but we agree they will be increasingly useful in the future.

Second, they comment on the role of analytic approaches to …
Predictive Factors for Survival in Sickle Cell Disease: A Cohort Study Using Etendard Data
Authors: Laurent Savale, Gylna Loko, François Lionnet, Bernard Maitre, Anoosha Habibi, Jocelyn Inamo, Dora Bachir, Françoise Driss, Vincent Audard, Etienne Audureau, Marc Humbert, Gerald Simonneau, Frédéric Galactéros, Florence Parent, Pablo Bartolucci
Journal: Blood (2018)
Impact Of FISH Abnormalities On Response To Lenalidomide In Patients With Multiple Myeloma
Authors: Shivlal Pandey, S. Vincent Rajkumar, Prashant Kapoor, Rhett P Ketterling, Martha Q Lacy, Morie A Gertz, Francis Buadi, David Dingli, Suzanne R Hayman, Angela Dispenzieri, Shaji K Kumar
Journal: Blood (2013)
Impaired Autophagy in CD11b <sup>+</sup> Dendritic Cells Expands CD4 <sup>+</sup> Regulatory T Cells and Limits Atherosclerosis in Mice
Authors: Marc Clement, Juliette Raffort, Fabien Lareyre, Dimitrios Tsiantoulas, Stephen Newland, Yuning Lu, Leanne Masters, James Harrison, Svetlana Saveljeva, Marcella K.L. Ma, Maria Ozsvar-Kozma, Brian Y.H. Lam, Giles S.H. Yeo, Christoph J. Binder, Arthur Kaser, Ziad Mallat
Journal: Circulation Research (2019)

Atherosclerosis is a chronic inflammatory disease. Recent studies have shown that dysfunctional autophagy in endothelial cells, smooth muscle cells, and macrophages, plays a detrimental role during atherogenesis, leading to the suggestion that autophagy-stimulating approaches may provide benefit.Dendritic cells (DCs) are at the crossroad of innate and adaptive immune responses and profoundly modulate the development of atherosclerosis. Intriguingly, the role of autophagy in DC function during atherosclerosis and how the autophagy process would impact disease development has not been addressed.Here, we show that the autophagic flux in atherosclerosis-susceptible Ldlr-/- (low-density lipoprotein receptor-deficient) mice is substantially higher in splenic and aortic DCs compared with macrophages and is further activated under hypercholesterolemic conditions. RNA sequencing and functional studies on selective cell populations reveal that disruption of autophagy through deletion of Atg16l1 differentially affects the biology and functions of DC subsets in Ldlr-/- mice under high-fat diet. Atg16l1 deficient CD11b+ DCs develop a TGF (transforming growth factor)-β-dependent tolerogenic phenotype and promote the expansion of regulatory T cells, whereas no such effects are seen with Atg16l1 deficient CD8α+ DCs. Atg16l1 deletion in DCs (all CD11c-expressing cells) expands aortic regulatory T cells in vivo, limits the accumulation of T helper cells type 1, and reduces the development of atherosclerosis in Ldlr-/- mice. In contrast, no such effects are seen when Atg16l1 is deleted selectively in conventional CD8α+ DCs and CD103+ DCs. Total T-cell or selective regulatory T-cell depletion abrogates the atheroprotective effect of Atg16l1 deficient DCs.In contrast to its proatherogenic role in macrophages, autophagy disruption in DCs induces a counter-regulatory response that maintains immune homeostasis in Ldlr-/- mice under high-fat diet and limits atherogenesis. Selective modulation of autophagy in DCs could constitute an interesting therapeutic target in atherosclerosis.
Abstract 470: Reactivation of Fetal MicroRNAs Contribute to Dilated Cardiomyopathy
Authors: Shreesti Shrestha, Xiaopeng Shen, Rui Liang, Fan Wang, Bradley K McConnell, Yu Liu
Journal: Circulation Research (2019)

Background: Dilated cardiomyopathy (DCM) is the most common cardiomyopathies that often leads to heart failure worldwide. MicroRNAs have emerged as an integral player in regulating diverse biological processes including those in the cardiovascular system. Previously, our lab has shown that the miR-424(322)/503 cluster is highly enriched during early cardiac fate determination and drives cardiomyocyte specification. However, the expression level of miR-424(322)/503 gradually decreases in the postnatal heart. Other studies have revealed the upregulation of miR-424(322)/503 in failing human hearts. Nevertheless, the association between miR-424(322)/503 and heart disease has not been studied yet. Methods and Results: In this study, we created transgenic mice (TG) with tetracycline-controlled cardiomyocyte-specific miR-424(322)/503 expression. The TG mice and control mice (8 weeks) were fed with doxycycline-containing chow for up to a month. During this period, the weight of the mice and cardiac function were monitored. The weight of TG mice dropped significantly while controls grew normally. Echocardiography analysis showed continuous deterioration of cardiac function starting from 2 weeks. Ejection fraction and fractional shortening (n=8) decreased to 46±1.9% and 22±1.09% at 2 weeks and 15±2.7% and 6±1.2% at 4 weeks, respectively. In addition, left ventricular internal diameter (LVID,d and LVID,s) increased from 3.64±0.098 and 2.5±0.085 to 4.2±0.2 and 3.9±0.18 respectively. Morphologically, we found the hearts of TG mice to be larger than WT mice. H and E staining revealed dilated ventricular chambers and thinning of ventricular walls in TG. Likewise, fibrosis was observed in TG hearts through Masson trichrome stain. In addition, both atrial natriuretic peptides and brain natriuretic peptides increased by &gt;8 folds in TG hearts (n=5). The level of β-MHC was higher while α-MHC was lower in TG hearts vs control. These indicate that TG phenotype is consistent with DCM. Conclusion: Overall, this is the first study showing that upregulated miR-424(322)/503 in the heart is sufficient to lead to DCM. This study can potentially help establish miR-424(322)/503 as a novel therapeutic target to ameliorate heart failure progression.
Effect of Fibrinogen Concentrate vs Cryoprecipitate on Blood Component Transfusion After Cardiac Surgery
Authors: Jeannie Callum, Michael E. Farkouh, Damon C. Scales, Nancy M. Heddle, Mark Crowther, Vivek Rao, Hans-Peter Hucke, Jo Carroll, Deep Grewal, Sukhpal Brar, Jean Bussières, Hilary Grocott, Christopher Harle, Katerina Pavenski, Antoine Rochon, Tarit Saha, Lois Shepherd, Summer Syed, Diem Tran, Daniel Wong, Michelle Zeller, Keyvan Karkouti
Journal: JAMA (2019)

Excessive bleeding is a common complication of cardiac surgery. An important cause of bleeding is acquired hypofibrinogenemia (fibrinogen level <1.5-2.0 g/L), for which guidelines recommend fibrinogen replacement with cryoprecipitate or fibrinogen concentrate. The 2 products have important differences, but comparative clinical data are lacking.To determine if fibrinogen concentrate is noninferior to cryoprecipitate for treatment of bleeding related to hypofibrinogenemia after cardiac surgery.Randomized clinical trial at 11 Canadian hospitals enrolling adult patients experiencing clinically significant bleeding and hypofibrinogenemia after cardiac surgery (from February 10, 2017, to November 1, 2018). Final 28-day follow-up visit was completed on November 28, 2018.Fibrinogen concentrate (4 g; n = 415) or cryoprecipitate (10 units; n = 412) for each ordered dose within 24 hours after cardiopulmonary bypass.Primary outcome was blood components (red blood cells, platelets, plasma) administered during 24 hours post bypass. A 2-sample, 1-sided test for the ratio of the mean number of units was conducted to evaluate noninferiority (threshold for noninferiority ratio, <1.2).Of 827 randomized patients, 735 (372 fibrinogen concentrate, 363 cryoprecipitate) were treated and included in the primary analysis (median age, 64 [interquartile range, 53-72] years; 30% women; 72% underwent complex operations; 95% moderate to severe bleeding; and pretreatment fibrinogen level, 1.6 [interquartile range, 1.3-1.9] g/L). The trial met the a priori stopping criterion for noninferiority at the interim analysis after 827 of planned 1200 patients were randomized. Mean 24-hour postbypass allogeneic transfusions were 16.3 (95% CI, 14.9 to 17.8) units in the fibrinogen concentrate group and 17.0 (95% CI, 15.6 to 18.6) units in the cryoprecipitate group (ratio, 0.96 [1-sided 97.5% CI, -∞ to 1.09; P < .001 for noninferiority] [2-sided 95% CI, 0.84 to 1.09; P = .50 for superiority]). Thromboembolic events occurred in 26 patients (7.0%) in the fibrinogen concentrate group and 35 patients (9.6%) in the cryoprecipitate group.In patients undergoing cardiac surgery who develop clinically significant bleeding and hypofibrinogenemia after cardiopulmonary bypass, fibrinogen concentrate is noninferior to cryoprecipitate with regard to number of blood components transfused in a 24-hour period post bypass. Use of fibrinogen concentrate may be considered for management of bleeding in patients with acquired hypofibrinogenemia in cardiac surgery.ClinicalTrials.gov Identifier: NCT03037424.
Multidisciplinary cancer teams and utilization of resources for metastatic breast cancer (MBC): A landscape analysis.
Authors: Elana Plotkin, Marianne Gandee, Lorna Lucas
Journal: Journal of Clinical Oncology (2019)

186 Background: An estimated 250k Americans are currently living with MBC. While breast cancer is a high-profile disease receiving significant public funding, patients with metastatic breast cancer face unique challenges. ACCC seeks to expand the conversation to address gaps between early &amp; metastatic disease and improve the management of MBC in the community setting. Communication challenges that cancer care teams face with MBC patients include: using a tailored and thoughtful approach, balancing hope and realism, patient engagement during conversations, incorporating principles of shared decision making, patient financial concerns, and family/caregiver involvement. Methods: An environmental scan was completed of nationally available resources. A survey on MBC Communication strategies was administered in a variety of oncology provider settings from Dec. 2018-Jan 2019. Results: Patient psychosocial needs were identified as the top challenge for working with MBC patients vs. Stage 1-3. 57% reported difficulty managing patient expectations, 55% reported patient financial concerns. While 66% of cancer programs offer a general breast cancer support group, only 27% offer a Stage 4 group. 59% of respondents rely on casual conversations with patients to assess what they want, only 34% ask patients to define what quality of life would mean for them. 33% document goals in the EMR. Over 150 free resources specific to MBC were categorized from diagnosis through hospice, resulting in a curated online library that clinicians can use with their patients. Conclusions: This patient population should be given specialized care to address their unique diagnosis and improve communications with their care team. The ACCC Resource Library gives both low and highly resourced programs access to more supportive care tailored to metastatic breast cancer.
Psychological safety and near miss events in radiation oncology.
Authors: Palak Kundu, Olivia Jung, Kathy Rose, Chonlawan Khaothiemsang, Nzhde Agazaryan, Amy Edmondson, Michael L. Steinberg, Ann C. Raldow
Journal: Journal of Clinical Oncology (2019)

231 Background: Near miss events, defined as harm averted due to chance, are learning opportunities in radiation oncology. Psychological safety is a feature of a learning environment characterized by interpersonal risk taking. We examine the effects of near miss type and psychological safety on reporting near miss events to an incident learning system. We posit that submission likelihood will differ based on near miss types and psychological safety. Methods: We administered a survey assessing psychological safety to members of a radiation oncology department. We then presented six events for a patient with a pacemaker (PM), which requires cardiac clearance before radiation: process-based (harm averted by systematic PM check); good catch (harm averted by incidental PM check); “could” event (harm averted by chance PM absence); “almost” event (positive PM status, but no sequelae); hit (positive PM status, subsequent arrhythmia); and control (no PM, checked PM status, no sequelae). Subjects ranked each event on submission likelihood (1 = most likely, 7 = least likely), scored events based on submission likelihood by others (1 = least likely, 7 = most likely), and rated event success (1 = failure, 7 = success). ANOVA was used to assess differences in mean rank, submission likelihood, and success ratings. Regression was used to assess the relationship between psychological safety and submission likelihood. Results: The survey yielded 95 out of 127 responses (75%). Mean ranks (p &lt; 0.0001), submission likelihood (p = .042), and success ratings (p &lt; 0.001) differed by near miss type; psychological safety predicted likelihood of submitting the different near miss types (Table 1). 14 respondents (15%) would mind if an incident was submitted about them, while 43 respondents (45%) assume others would mind if an incident was reported related to the others (score &gt; 4). Conclusions: Near miss events proximal to a negative outcome are more likely to be reported, though this effect may be mediated by psychological safety. [Table: see text]