tbuckley/cabot-search huggingface dataset:
Assessment of Topical Corticosteroid Prescribing, Counseling, and Communication Among Dermatologists and Pharmacists
Authors: Ashley N. Millard, Erik J. Stratman
Journal: JAMA Dermatology (2019)

<h3>Importance</h3> Topical corticosteroids (TCs) are common treatments for many dermatologic conditions. Anecdotal experience and literature suggest that dermatologists and pharmacists differ in their beliefs about TCs and approach to TC counseling, creating the opportunity for patient confusion. <h3>Objective</h3> To examine interprofessional practice gaps between dermatologists and pharmacists with regard to how each group views TCs, counsels patients on TC use, and communicates modifications to TC prescriptions. <h3>Design, Setting, and Participants</h3> An electronic survey was disseminated statewide in Wisconsin to 117 board-certified or eligible dermatologist members of the Wisconsin Dermatological Society and 2954 licensed pharmacists. The survey was performed from October 11, 2017, to January 2, 2018. Survey responses and demographic information were compiled and analyzed for each population. <h3>Exposures</h3> Study participants completed and returned a 17-question survey recalling experiences with TC prescribing from the past year along with self-reported demographic information. <h3>Main Outcomes and Measures</h3> Dermatologists' and pharmacists' self-reported counseling of patients regarding TC application, duration of use, and adverse effects; frequency of communication of changes to TC prescriptions and instructions; and demographic data were tabulated and compared. <h3>Results</h3> Of the 117 dermatologists, 52 (44.4%) completed and returned the survey; of the 2954 pharmacists, 111 (3.8%) returned the survey. Those no longer in active practice (3 dermatologists, 1 pharmacist) were excluded from analysis. A substantial proportion of pharmacists (51 [46.4%]) advised patients to limit TC use to 2 weeks or less, which was an uncommon strategy among dermatologists (3 [6.1%]) (<i>P</i> &lt; .001). Discordance also was noted in the adverse effects that are emphasized in counseling, pharmacist-perceived and dermatologist-observed adverse effects in patients, and resources that inform counseling content. Only 8 (16.3%) dermatologists perceived that pharmacists made no unauthorized modifications to their TC prescriptions or instructions; however, 77 (70.0%) pharmacists reported not doing so (<i>P</i> &lt; .001). <h3>Conclusions and Relevance</h3> An interprofessional practice gap appears to exist between dermatologists and pharmacists in Wisconsin regarding TC beliefs and counseling strategies. Collaborative education and improved communication between the 2 groups may be necessary to ensure that patients receive a unified, clear message about TC application and adverse effects. Larger studies are needed to further investigate this potential practice gap.
Comparison of Population-Based Observational Studies With Randomized Trials in Oncology
Authors: Payal D. Soni, Holly E. Hartman, Robert T. Dess, Ahmed Abugharib, Steven G. Allen, Felix Y. Feng, Anthony L. Zietman, Reshma Jagsi, Matthew J. Schipper, Daniel E. Spratt
Journal: Journal of Clinical Oncology (2019)

Comparative efficacy research performed using population registries can be subject to significant bias. There is an absence of objective data demonstrating factors that can sufficiently reduce bias and provide accurate results.MEDLINE was searched from January 2000 to October 2016 for observational studies comparing two treatment regimens for any diagnosis of cancer, using SEER, SEER-Medicare, or the National Cancer Database. Reporting quality and statistical methods were assessed using components of the STROBE criteria. Randomized trials comparing the same treatment regimens were identified. Primary outcome was correlation between survival hazard ratio (HR) estimates provided by the observational studies and randomized trials. Secondary outcomes included agreement between matched pairs and predictors of agreement.Of 3,657 studies reviewed, 350 treatment comparisons met eligibility criteria and were matched to 121 randomized trials. There was no significant correlation between the HR estimates reported by observational studies and randomized trials (concordance correlation coefficient, 0.083; 95% CI, -0.068 to 0.230). Forty percent of matched studies were in agreement regarding treatment effects (κ, 0.037; 95% CI, -0.027 to 0.1), and 62% of the observational study HRs fell within the 95% CIs of the randomized trials. Cancer type, data source, reporting quality, adjustment for age, stage, or comorbidities, use of propensity weighting, instrumental variable or sensitivity analysis, and well-matched study population did not predict agreement.We were unable to identify any modifiable factor present in population-based observational studies that improved agreement with randomized trials. There was no agreement beyond what is expected by chance, regardless of reporting quality or statistical rigor of the observational study. Future work is needed to identify reliable methods for conducting population-based comparative efficacy research.
Review of Ilana Löwy, <i>Imperfect Pregnancies: A History of Birth Defects &amp; Prenatal Diagnosis</i>
Authors: Kirsten A. Riggan
Journal: The American Journal of Bioethics (2019)

Ilana Lowy’s recent monograph, Imperfect Pregnancies: A History of Birth Defects & Prenatal Diagnosis, is a timely and informative historical overview tracing the fascination of “monstrous births” ...
Immunologic Characterization of Tumor Antigen-Specific T Cells in Multiple Myeloma: Implication in Immune Checkpoint Blockade
Authors: Yoon Seok Choi, Minsuk Kwon, Ik Chan Song, Hyo Jin Lee, Hwan Jung Yun, Deog-Yeon Jo, Eui-Cheol Shin
Journal: Blood (2017)
68Ga-DOTANOC PET/CT in an Atypical Extraskeletal Paravertebral Hemangioma Mimicking as Neurogenic Tumor in a Known Case of Breast Cancer
Authors: Shelvin Kumar Vadi, Bhagwant Rai Mittal, Ashwin Singh Parihar, Rajender Kumar, Harmandeep Singh, Gurpreet Singh
Journal: Clinical Nuclear Medicine (2019)

Ga-DOTANOC PET/CT is well documented in evaluation of well-differentiated neuroendocrine tumors and in other lesions with somatostatin receptor expression such as pheochromocytoma, paraganglioma, neuroblastoma, meningioma, and mesenchymal tumors causing oncogenic osteomalacia. Causes of interpretative pitfalls include prominent pancreatic uncinate process activity, inflammation, osteoblastic activity (degenerative bone disease/fracture/vertebral hemangioma), splenunculi/splenosis, and others. We present a case of extraskeletal paravertebral lesion detected in a known case of breast cancer with increased Ga-DOTANOC uptake later proved to be hemangioma. This is a novel finding and should be kept as a rare benign differential in evaluation of lesions with somatostatin receptor expression.
David Oliver: Should we use pay incentives for shortage specialties?
Authors: David Oliver
Journal: BMJ (2019)

The crisis in recruitment and retention of the clinical workforce is the biggest threat to the viability of the health service in the UK. This stark reality has been acknowledged by think tanks, royal colleges, unions, professional organisations, and NHS leadership bodies.123

One in 10 medical vacancies is unfilled,4 and in the annual British Social Attitudes survey the public cited staff pressures and shortages as key concerns. Some clinical specialties are struggling especially hard to fill posts and to retain staff close to retirement age, with big geographical inequities.5 We need a whole variety of actions to train, support, re-enthuse, and retain more staff.

Might pay incentives …
Blockade of CD40–CD154 pathway interactions suppresses ectopic lymphoid structures and inhibits pathology in the NOD/ShiLtJ mouse model of Sjögren’s syndrome
Authors: Grazyna Wieczorek, Marc Bigaud, Sabina Pfister, Melanie Ceci, Katriona McMichael, Catherine Afatsawo, Meike Hamburger, Celine Texier, Maurane Henry, Celine Cojean, Marinette Erard, Nadja Mamber, James S Rush
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Objective</h3> To examine the role of CD40–CD154 costimulation and effects of therapeutic pathway blockade in the non-obese diabetic (NOD/ShiLtJ) model of Sjögren's syndrome (SS). <h3>Methods</h3> We assessed leucocyte infiltration in salivary glands (SGs) from NOD/ShiLtJ mice by immunohistochemistry and examined transcriptomics data of SG tissue from these animals for evidence of a CD40 pathway gene signature. Additionally, we dosed MR1 (anti-CD154 antibody) in NOD mice after the onset of SS-like disease and examined the effects of MR1 treatment on sialadenitis, autoantibody production, SG leucocyte infiltration, gene expression downstream of CD40 and acquaporin 5 (AQP5) expression. <h3>Results</h3> We could detect evidence of CD40 expression and pathway activation in SG tissue from NOD mice. Additionally, therapeutic treatment with MR1 suppressed CD40 pathway genes and sialadenitis, inhibited ectopic lymphoid structure formation and autoantibody production, as well as decreased the frequency of antibody-secreting cells in SGs but had minimal effects on AQP5 expression in NOD/ShiLtJ SGs. <h3>Conclusion</h3> CD40–CD154 interactions play an important role in key pathological processes in a mouse model of SS, suggesting that blockade of this costimulatory pathway in the clinic may have beneficial therapeutic effects in patients suffering from this autoimmune exocrinopathy.
Race and Ethnicity Data in Research—Reply
Authors: Vence L. Bonham, Eric D. Green, Eliseo J. Pérez-Stable
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Appearance of Florid Cemento-Osseous Dysplasia on SPECT/CT
Authors: Dorothy Daiyi Yang, Abeer Ghuman, Richard Stratton, Margaret Hall, Arum Parthipun
Journal: Clinical Nuclear Medicine (2019)

Florid cemento-osseous dysplasia, a benign fibro-osseous condition, is diagnosed based on characteristic radiographic appearances of multifocal round or lobulated sclerotic lesions associated with the teeth in multiple quadrants of the jaws. We report a case of a 73-year-old woman who presented with a painless sharp bony area on the right side of her maxilla. SPECT/CT of facial bones demonstrated multifocal intense increased uptake in both the maxilla and mandible, corresponding to ill-defined florid sclerotic periapical lesions seen on CT, in keeping with a classical appearance of florid cemento-osseous dysplasia.
Abstract 218: Cardiac Side Population Cells Give Rise to Cardiomyocytes in the Adult Heart
Authors: Amritha Yellamilli, Ingrid Bender, Yi Ren, Jop H van Berlo
Journal: Circulation Research (2016)

Therapies that enhance cardiac regeneration have the potential to improve heart failure outcomes. One strategy to enhance cardiac regeneration is by activating endogenous cardiac progenitor cells. Cardiac side population cells (cSPCs) are proposed progenitor cells that reside in the heart; however, their putative progenitor cell properties are based on cell culture data and transplantation studies performed with isolated cSPCs. To determine the endogenous regenerative potential of cSPCs in vivo , we generated a mouse model that harbors an Abcg2-driven, tamoxifen-inducible Cre recombinase and crossed it to a GFP reporter mice. One month after tamoxifen treatment, we obtained efficient GFP-labeling of side population cells with 47.0 ± 11.05% of bone marrow side population cells and 75.8 ± 10.87% of cSPCs. Importantly, during a one-month chase period, we observed a three-fold increase in GFP-labeled cardiomyocytes when compared to a 1-week chase period. We quantified the extent of GFP-labeling of cardiomyocytes using adult cardiomyocyte isolation, where we measured 0.8% GFP labeled cardiomyocytes after a one-month chase period. We also observed labeling of many other cell types in the heart, such as endothelial cells, smooth muscle cells, and pericytes. We are currently testing to what extent cardiac injury enhances cSPC derived cardiomyocyte formation. Using our mouse model that efficiently labels side population cells in vivo , we demonstrated that cSPCs contribute cardiomyocytes in the adult heart in vivo .
The Impact of Antimicrobial Prophylaxis during Induction Chemotherapy for Acute Myeloid Leukemia in the Current Era
Authors: Marla M. Jalbut, Evan C. Chen, Gabriela S. Hobbs, Ashley M. Perry, Lillian Werner, Philip C. Amrein, Amir T. Fathi, Andrew M. Brunner
Journal: Blood (2017)
Notice of Retraction and Replacement. Dyrbye et al. Association of Clinical Specialty With Symptoms of Burnout and Career Choice Regret Among US Resident Physicians. <i>JAMA</i>. 2018;320(11):1114-1130
Authors: Jeph Herrin, Liselotte N. Dyrbye
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prescription of Glucagon-Like Peptide-1 Receptor Agonists by Cardiologists
Authors: Muthiah Vaduganathan, Ravi B. Patel, Avinainder Singh, Cian P. McCarthy, Arman Qamar, James L. Januzzi, Benjamin M. Scirica, Javed Butler, Christopher P. Cannon, Deepak L. Bhatt
Journal: Journal of the American College of Cardiology (2019)
Pharmacologic and Nonpharmacologic Treatments for Urinary Incontinence in Women
Authors: Ethan M. Balk, Valerie N. Rofeberg, Gaelen P. Adam, Hannah J. Kimmel, Thomas A. Trikalinos, Peter C. Jeppson
Journal: Annals of Internal Medicine (2019)

Background: Urinary incontinence (UI), a common malady in women, most often is classified as stress, urgency, or mixed. Purpose: To compare the effectiveness of pharmacologic and nonpharmacologic interventions to improve or cure stress, urgency, or mixed UI in nonpregnant women. Data Sources: MEDLINE, Cochrane Central Register of Controlled Trials (Wiley), Cochrane Database of Systematic Reviews (Wiley), EMBASE (Elsevier), CINAHL (EBSCO), and PsycINFO (American Psychological Association) from inception through 10 August 2018. Study Selection: 84 randomized trials that evaluated 14 categories of interventions and reported categorical cure or improvement outcomes. Data Extraction: 1 researcher extracted study characteristics, results, and study-level risk of bias, with verification by another independent researcher. The research team collaborated to assess strength of evidence (SoE) across studies. Data Synthesis: 84 studies reported cure or improvement outcomes (32 in stress UI, 16 in urgency UI, 4 in mixed UI, and 32 in any or unspecified UI type). The most commonly evaluated active intervention types included behavioral therapies, anticholinergics, and neuromodulation. Network meta-analysis showed that all interventions, except hormones and periurethral bulking agents (variable SoE), were more effective than no treatment in achieving at least 1 favorable UI outcome. Among treatments used specifically for stress UI, behavioral therapy was more effective than either α-agonists or hormones in achieving cure or improvement (moderate SoE); α-agonists were more effective than hormones in achieving improvement (moderate SoE); and neuromodulation was more effective than no treatment for cure, improvement, and satisfaction (high SoE). Among treatments used specifically for urgency UI, behavioral therapy was statistically significantly more effective than anticholinergics in achieving cure or improvement (high SoE), both neuromodulation and onabotulinum toxin A (BTX) were more effective than no treatment (high SoE), and BTX may have been more effective than neuromodulation in achieving cure (low SoE). Limitation: Scarce direct (head-to-head trial) evidence and population heterogeneity based on UI type, UI severity, and history of prior treatment. Conclusion: Most nonpharmacologic and pharmacologic interventions are more likely than no treatment to improve UI outcomes. Behavioral therapy, alone or in combination with other interventions, is generally more effective than pharmacologic therapies alone in treating both stress and urgency UI. Primary Funding Source: Patient-Centered Outcomes Research Institute. (PROSPERO: CRD42017069903)
HPV self testing to be piloted in two areas
Authors: Harriet Pike
Journal: BMJ (2019)

Women who fail to attend cervical screening in northeast London and north central London are to be sent human papillomavirus self sampling kits as part of a pilot, Public Health England has confirmed.

The agency is working with King’s College London and the University College London Hospital Cancer Collaborative to test whether HPV self sampling can be implemented, as part of an initiative aimed at combating the low uptake of cervical cancer screening tests in England.

Anne Mackie, director of screening programmes at PHE, said that the pilot, which is due to start in September 2019, was “in its early stages.”

The London pilot will offer 22 000 self sampling kits by post to women’s homes or when women consult their GP for other reasons. Women can mail their sample directly for laboratory …
AB0222 Evaluation of the visual analogical scales (vas) of pain and their correlation with the others acr activity criteria of rehumatoid arthritis (ra)
Authors: C Diaz, M Cortes, C Geli, M Moreno, H Corominas, C Diaz-Torne, A Rodriguez, JM Llobet, G Vazquez
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> <h3>Objectives</h3> Evaluate the VAS for global, activity, rest and nocturnal pain in relation with other activity parameters including Ritchie index. <h3>Methods</h3> 228 outpatients with ACR-87 criteria for RA diagnostic were studied. We measure the following clinical parameters: nº of joints with pain and inflammation, VAS for global, activity, rest and nocturnal pain, VAS for global impression of the patient and the doctor, HAQ, morning stiffness, Ritchie index and the analytical data: ESR and CRP. The correlations among the different pain-VAS and those with other activity criteria of RA were evaluated by Pearson’s correlation with the statistical packet SPSS. They are positive if r &gt; .5. <h3>Results</h3> 82% were women. Age was 60 ± 16. Years of evolution were 13 ± 10. 31%, 28%, 29% and 12% correspond to the functional stages I, II, III and IV respectively. 48% were seropositive. VAS-G has the highest correlations with VAS-A, R and N. there are also significant correlation among VAS-Pain and other activity parameters of RA: HAQ, Ritchie index and the global impression of the patient and the doctor. The impression of the patient correlations are higher than the doctor’s. <h3>Conclusion</h3> VAS-Pain, and specially VAS-G has a high correlation among themselves, HAQ, patient and doctor’s impression and with Ritchie Index. There are no correlation among nº of articulations with pain, articulations with inflammation, CRP or ESR. The lack of the last correlation maybe related to the low inflammatory activity of the sample.
Biomimetic engineering endothelium-like coating on cardiovascular stent through heparin and nitric oxide-generating compound synergistic modification strategy
Authors: Hua Qiu, Pengkai Qi, Jingxia Liu, Ying Yang, Xing Tan, Yu Xiao, Manfred F. Maitz, Nan Huang, Zhilu Yang
Journal: Biomaterials (2019)
Compounded Pain Creams Offer No Benefit
Authors: Anita Slomski
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal