tbuckley/cabot-search huggingface dataset:
Abstract 18444: Low and Exacerbated Levels Of 1,5-anhydroglucitol are Associated With Cardiovascular Events in Patients After First-time Elective Percutaneous Coronary Intervention
Authors: Shuhei Takahashi, Kazunori Shimada, Katsumi Miyauchi, Eiryu Sai, Tetsuro Miyazaki, Tomoyuki Shiozawa, Hiroshi Tamura, Shinya Okazaki, Kikuo Isoda, Hiroyuki Daida
Journal: Circulation (2015)

Background: There has recently been great interest in the association between postprandial hyperglycemia and coronary artery disease. Serum 1,5-anhydroglucitol (1,5-AG) is reported to be a clinical marker of postprandial hyperglycemia. However, the impact of 1,5-AG on cardiovascular events has not been fully investigated. Methods: We enrolled 270 consecutive patients who had undergone first-time elective percutaneous coronary intervention (PCI) with follow-up angiography within 1 year. Fasting blood glucose (FBS) levels, HbA1c, and 1,5-AG were measured prior to PCI and at the time of follow-up angiography. Clinical events, including ACS and coronary revascularization, were also evaluated. Subjects were divided into two groups according to clinical outcomes: event group (EV, n=48) and non-event group (NEV, n=222). Patients were also divided into four groups according to 1,5-AG levels prior to PCI and at follow-up: increased 1,5-AG group (Group A), persistently low 1,5-AG group (Group B), persistently high 1,5-AG group (Group C) and decreased 1,5-AG group (Group D). Results: No significant differences in baseline clinical characteristics were observed between the two or the four 1,5-AG groups. Serum levels of 1,5-AG at follow-up were significantly lower in the EV group than in the NEV group (P=0.04). Significant reduction in 1,5-AG level was observed in the EV group than in the NEV group (P = 0.03). The association between 1,5-AG levels and clinical events remained significant after adjustment for independent variables, including FBS and HbA1c levels (P=0.04). The incidence of cardiovascular events was significantly higher in Group D than the other 1,5-AG groups. (Figure) Conclusion: Low and exacerbated levels of 1,5-AG were associated with cardiovascular events, suggesting that postprandial hyperglycemia and low 1,5-AG are important risk factors for adverse clinical events in patients after first-time elective PCI.
Annals Graphic Medicine - Progress Notes: Tethered
Authors: Michael Natter
Journal: Annals of Internal Medicine (2019)

Web Exclusives21 May 2019Annals Graphic Medicine - Progress Notes: TetheredFREEMichael Natter, MDMichael Natter, MDNYU School of Medicine, New York, New York (M.N.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/G19-0001 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Download figure Download PowerPoint Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: NYU School of Medicine, New York, New York (M.N.)Disclosures: The author has disclosed no conflicts of interest. The form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=G19-0002.Author/Illustrator Information: Michael Natter, MD, is a current internal medicine resident at NYU School of Medicine and a graduate of Sidney Kimmel Medical College of Thomas Jefferson University in Philadelphia. His artwork is inspired by his medical training, patient encounters, and the human condition. A type 1 diabetic, Dr. Natter views himself as a patient as well as a doctor and plans to pursue a fellowship in endocrinology to help others who also share his disease. You can find more of his illustrations, stories, and comics on Instagram (www.instagram.com/mike.natter) and Twitter (@mike_natter).About Progress Notes: Progress Notes explores the everyday emotional, clinical, humorous, and ethical challenges of the medical residency training process. As implied by the title of the series, these pieces act as a visual bildungsroman, graphically dissecting the subtext of what it means to be a young doctor in today's medical world. Progress Notes appears monthly in Annals Graphic Medicine at Annals.org. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 21 May 2019Volume 170, Issue 10Page: W114-W115KeywordsConflicts of interestDisclosureEmotionsEndocrinologyFellowshipsGraduate medical educationResidency ePublished: 21 May 2019 Issue Published: 21 May 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Advances in therapeutic applications of extracellular vesicles
Authors: Oscar P. B. Wiklander, Meadhbh Á. Brennan, Jan Lötvall, Xandra O. Breakefield, Samir EL Andaloussi
Journal: Science Translational Medicine (2019)

Understanding extracellular vesicle biology and production will pave the way for a new type of biotherapeutic.
Abstract 1823: Mechanism of the anterograde transport of the androgen receptor
Authors: Jianzhuo Li, Guanyi Zhang, Hee-Won Park, Haitao Zhang
Journal: Cancer Research (2016)

Abstract Androgen receptor (AR) is a ligand-activated nuclear receptor that plays a critical role in normal prostate physiology, as well as in the development and progression of prostate cancer. In addition to the classical paradigm in which AR exerts its biological effects by activating the transcription of its target genes, there is considerable evidence to support a rapid, non-genomic action mediated by membrane-associated AR, which facilitates the activation of kinase signaling cascades, leading to cell proliferation. While the nuclear translocation of AR is well studied, the molecular events controlling the recruitment of AR to the plasma membrane remain poorly understood. In this study, we set out to elucidate the mechanism underlying AR transport to the membrane. We found that a subpopulation of AR was localized to the membrane fraction shortly after androgen stimulation. Treatment with microtubule-targeting agents, but not actin inhibitors, blocked androgen-induced AR membrane localization, suggesting that AR transport to the membrane is mediated by the microtubule cytoskeleton. By utilizing dominant negative mutants, we identified the KIF5B, a member of the kinesin 1 family of motor proteins, is involved in the anterograde transport of AR. We further demonstrated that AR interacts directly with KIF5B, and such interaction is enhanced by androgens. Through a series of deletion constructs, a region includes the N-terminal and DNA binding domains of AR was determined to be involved in the association with KIF5B. Disruption of AR membrane transport decreased AKT phosphorylation. Together, our data suggest that KIF5B mediates AR membrane transport and regulates the non-genomic function of AR. Disruption of AR membrane translocation may represent a novel strategy to target AR signaling in prostate cancer. Citation Format: Jianzhuo Li, Guanyi Zhang, Hee-Won Park, Haitao Zhang. Mechanism of the anterograde transport of the androgen receptor. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 1823.
Abstract 10325: Epicardial Erythropoietin Patch Improves Cardiac Functions and Induces Stem Cell Associated Regeneration After Myocardial Infarction
Authors: Christian Klopsch, Gabriela Kleiner, Marion Ludwig, Ralf Gaebel, Anna Skorska, Petra Mela, Stefan Jockenhoevel, Gustav Steinhoff
Journal: Circulation (2013)

High-dose intramyocardial Erythropoietin (EPO) therapy protects the myocardium from ischemic injury and promotes beneficial remodelling. We investigated the therapeutic efficacy of EPO at a moderate dose level and compared local and systemic delivery routes in a rat myocardial infarction (MI) model. Following MI, EPO (300 U/kg) was delivered immediately by intraperitoneal (EPO-S, n=25) injection, intramyocardial (EPO-L, n=23) injection or epicardially as an EPO-plus-fibrin patch (EPO-X, n=26). Groups were compared to each other and MI control groups with saline injections (MIC, n=25) or saline-plus-fibrin patch application (MIC-X, n=29). Heart functions were examined under baseline and Dobutamine-induced stress conditions using conductance catheter method 6 weeks after MI. Moreover, blood and myocardium were analysed including candidate genes and proteins at early (24 hours) and late (6 weeks) stages after MI. Results illustrated superior cardiac functions and healing in EPO-X compared with all groups at ...
HEMOSPRAY FOR GASTROINTESTINAL BLEEDING: EFFECTIVENESS, PREDICTORS OF FAILURE AND SURVIVAL IN A NATIONWIDE STUDY
Authors: E Rodríguez de Santiago, D Burgos Santamaría, L Pérez Carazo, A Teran Lantaron, E Brullet, S Prados Leira, F Riu Pons, I Fernández-Urién Sainz, I Becerro González, M Angel de Jorge Turrión, C Ferre Aracil, C Rodríguez Escaja, D Perez Corte, N Volpato Machado, E Martínez Moneo, FJ García Alonso, CM Chavarría Herbozo, S Sevilla Ribota, R Borobia Sanchez, E Martínez Bauer, L Ciriano Hernández, A Barturen Barroso, C Santander Vaquero, A Guerrero García, HMM Prieto, A López Serrano, M López Ibañez, O Murcia Palomares, G Pagano, D Oyón Lara, C Froilan Torres, D Coto Ugarte, M González-Haba Ruíz, M de Benito Sanz, C Carbonell Blanco, O Nogales Rincón, I Ortiz Polo, D Juzgado de Lucas, S Parejo Carbonell, B Peñas García, J Aranda Hernández, J García Lledó, A Ibañez Pinto, E Vazquez Sequeiros, A Albillos
Journal: Endoscopy (2019)

This study aimed to assess the effectiveness, safety and predictors of Hemospray failure in a large real-life cohort.
Prevention of Venous Thromboembolism in Colorectal Surgery With Enoxaparin
Authors: Juan I. Arcelus
Journal: JAMA Surgery (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
The association of scalp psoriasis with overall psoriasis severity and koebnerization in children: cross‐sectional findings from the Dutch Child‐CAPTURE registry
Authors: I.M.G.J. Bronckers, M. Maatkamp, W. Kievit, P.C.M. van de Kerkhof, E.M.G.J. de Jong, M.M.B. Seyger
Journal: British Journal of Dermatology (2019)
Inhibition of ATM Increases Interferon Signaling and Sensitizes Pancreatic Cancer to Immune Checkpoint Blockade Therapy
Authors: Qiang Zhang, Michael D. Green, Xueting Lang, Jenny Lazarus, Joshua D. Parsels, Shuang Wei, Leslie A. Parsels, Jiaqi Shi, Nithya Ramnath, Daniel R. Wahl, Marina Pasca di Magliano, Timothy L. Frankel, Ilona Kryczek, Yu L. Lei, Theodore S. Lawrence, Weiping Zou, Meredith A. Morgan
Journal: Cancer Research (2019)

Abstract Combinatorial strategies are needed to overcome the resistance of pancreatic cancer to immune checkpoint blockade (ICB). DNA damage activates the innate immune response and improves ICB efficacy. Because ATM is an apical kinase in the radiation-induced DNA damage response, we investigated the effects of ATM inhibition and radiation on pancreatic tumor immunogenicity. ATM was inhibited through pharmacologic and genetic strategies in human and murine pancreatic cancer models both in vitro and in vivo. Tumor immunogenicity was evaluated after ATM inhibition alone and in combination with radiation by assessing TBK1 and Type I interferon (T1IFN) signaling as well as tumor growth following PD-L1/PD-1 checkpoint inhibition. Inhibition of ATM increased tumoral T1IFN expression in a cGAS/STING-independent, but TBK1- and SRC-dependent, manner. The combination of ATM inhibition with radiation further enhanced TBK1 activity, T1IFN production, and antigen presentation. Furthermore, ATM silencing increased PD-L1 expression and increased the sensitivity of pancreatic tumors to PD-L1–blocking antibody in association with increased tumoral CD8+ T cells and established immune memory. In patient pancreatic tumors, low ATM expression inversely correlated with PD-L1 expression. Taken together, these results demonstrate that the efficacy of ICB in pancreatic cancer is enhanced by ATM inhibition and further potentiated by radiation as a function of increased tumoral immunogenicity, underscoring the potential of ATM inhibition in combination with ICB and radiation as an efficacious treatment strategy for pancreatic cancer. Significance: This study demonstrates that ATM inhibition induces a T1IFN-mediated innate immune response in pancreatic cancer that is further enhanced by radiation and leads to increased sensitivity to anti–PD-L1 therapy. See related commentary by Gutiontov and Weichselbaum, p. 3815
Craniofacial Bone‐Tissue Engineering: Heparin‐Conjugated Decellularized Bone Particles Promote Enhanced Osteogenic Signaling of PDGF‐BB to Adipose‐Derived Stem Cells in Tissue Engineered Bone Grafts (Adv. Healthcare Mater. 10/2019)
Authors: Alexandra N. Rindone, Bartlomiej Kachniarz, Chukwuebuka C. Achebe, Ryan C. Riddle, Aine N. O'Sullivan, Amir H. Dorafshar, Warren L. Grayson
Journal: Advanced Healthcare Materials (2019)

In article number 1801565 by Warren L. Grayson and co-workers, a biomimetic growth factor delivery platform is developed to chemically conjugate heparin to osteoinductive, decellularized bone particles and allow for electrostatic tethering of platelet-derived growth factor. Bone particles with tethered growth factor promote bone mineral deposition by adipose-derived stem cells in vitro, and enhance bone formation mediated by these stem cells in vivo within murine critical-sized calvarial defects.
Differentiating disease activity from damage in systemic sclerosis: it’s still early days!
Authors: Siddharth Jain, Shefali Khanna Sharma
Journal: Annals of the Rheumatic Diseases (2019)

We read with great interest the article ‘Development and validation of the Scleroderma Clinical Trials Consortium Damage Index (SCTC-DI): a novel instrument to quantify organ damage in systemic sclerosis’ by Ferdowsi et al .1 We commend the authors’ to have come up with the much-needed concept of a damage index in systemic sclerosis. Differentiating activity from chronicity or damage is one of the key aspects in treatment of all rheumatological disorders and dictates the aggressiveness of treatment strategies employed. This differentiation is especially difficult in systemic sclerosis, owing to our incomplete understanding of the multifaceted pathogenesis of this complex disorder. What is currently believed to be irreversible (ie, damage) may in fact be reversible (ie, activity).

The SCTC-DI offers a promising outcome assessment tool for future clinical trials, but its clinical utility seems limited at present. Role of a damage index …
Radiogenomics Consortium Genome-Wide Association Study Meta-Analysis of Late Toxicity After Prostate Cancer Radiotherapy
Authors: Sarah L Kerns, Laura Fachal, Leila Dorling, Gillian C Barnett, Andrea Baran, Derick R Peterson, Michelle Hollenberg, Ke Hao, Antonio Di Narzo, Mehmet Eren Ahsen, Gaurav Pandey, Søren M Bentzen, Michelle Janelsins, Rebecca M Elliott, Paul D P Pharoah, Neil G Burnet, David P Dearnaley, Sarah L Gulliford, Emma Hall, Matthew R Sydes, Miguel E Aguado-Barrera, Antonio Gómez-Caamaño, Ana M Carballo, Paula Peleteiro, Ramón Lobato-Busto, Richard Stock, Nelson N Stone, Harry Ostrer, Nawaid Usmani, Sandeep Singhal, Hiroshi Tsuji, Takashi Imai, Shiro Saito, Rosalind Eeles, Kim DeRuyck, Matthew Parliament, Alison M Dunning, Ana Vega, Barry S Rosenstein, Catharine M L West
Journal: JNCI Journal of the National Cancer Institute (2019)

Abstract Background A total of 10%–20% of patients develop long-term toxicity following radiotherapy for prostate cancer. Identification of common genetic variants associated with susceptibility to radiotoxicity might improve risk prediction and inform functional mechanistic studies. Methods We conducted an individual patient data meta-analysis of six genome-wide association studies (n = 3871) in men of European ancestry who underwent radiotherapy for prostate cancer. Radiotoxicities (increased urinary frequency, decreased urinary stream, hematuria, rectal bleeding) were graded prospectively. We used grouped relative risk models to test associations with approximately 6 million genotyped or imputed variants (time to first grade 2 or higher toxicity event). Variants with two-sided Pmeta less than 5 × 10−8 were considered statistically significant. Bayesian false discovery probability provided an additional measure of confidence. Statistically significant variants were evaluated in three Japanese cohorts (n = 962). All statistical tests were two-sided. Results Meta-analysis of the European ancestry cohorts identified three genomic signals: single nucleotide polymorphism rs17055178 with rectal bleeding (Pmeta = 6.2 × 10−10), rs10969913 with decreased urinary stream (Pmeta = 2.9 × 10−10), and rs11122573 with hematuria (Pmeta = 1.8 × 10−8). Fine-scale mapping of these three regions was used to identify another independent signal (rs147121532) associated with hematuria (Pconditional = 4.7 × 10−6). Credible causal variants at these four signals lie in gene-regulatory regions, some modulating expression of nearby genes. Previously identified variants showed consistent associations (rs17599026 with increased urinary frequency, rs7720298 with decreased urinary stream, rs1801516 with overall toxicity) in new cohorts. rs10969913 and rs17599026 had similar effects in the photon-treated Japanese cohorts. Conclusions This study increases the understanding of the architecture of common genetic variants affecting radiotoxicity, points to novel radio-pathogenic mechanisms, and develops risk models for testing in clinical studies. Further multinational radiogenomics studies in larger cohorts are worthwhile.
Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3
Authors: Matthias von Gamm, Annalisa Schaub, Alisha N. Jones, Christine Wolf, Gesine Behrens, Johannes Lichti, Katharina Essig, Anna Macht, Joachim Pircher, Andreas Ehrlich, Kathrin Davari, Dhruv Chauhan, Benjamin Busch, Wolfgang Wurst, Regina Feederle, Annette Feuchtinger, Matthias H. Tschöp, Caroline C. Friedel, Stefanie M. Hauck, Michael Sattler, Arie Geerlof, Veit Hornung, Vigo Heissmeyer, Christian Schulz, Mathias Heikenwalder, Elke Glasmacher
Journal: The Journal of Experimental Medicine (2019)

The RNase Regnase-1 is a master RNA regulator in macrophages and T cells that degrades cellular and viral RNA upon NF-κB signaling. The roles of its family members, however, remain largely unknown. Here, we analyzed Regnase-3-deficient mice, which develop hypertrophic lymph nodes. We used various mice with immune cell-specific deletions of Regnase-3 to demonstrate that Regnase-3 acts specifically within myeloid cells. Regnase-3 deficiency systemically increased IFN signaling, which increased the proportion of immature B and innate immune cells, and suppressed follicle and germinal center formation. Expression analysis revealed that Regnase-3 and Regnase-1 share protein degradation pathways. Unlike Regnase-1, Regnase-3 expression is high specifically in macrophages and is transcriptionally controlled by IFN signaling. Although direct targets in macrophages remain unknown, Regnase-3 can bind, degrade, and regulate mRNAs, such as Zc3h12a (Regnase-1), in vitro. These data indicate that Regnase-3, like Regnase-1, is an RNase essential for immune homeostasis but has diverged as key regulator in the IFN pathway in macrophages.
EUS-GUIDED PLACEMENT OF NEW GOLDEN FIDUCIAL MARKERS IN STEREOTACTIC BODY RADIATION THERAPY IN LOCALLY ADVANCED PANCREATIC CANCER: PRELIMINARY RESULTS OF FEASIBILITY AND SAFETY
Authors: F Auriemma, M Di Leo, T Comito, L Lamonaca, A Fugazza, A Anderloni, P Bossi, R Maselli, E Chiara Ferrara, P Alessia Galtieri, M Scorsetti, A Repici, S Carrara
Journal: Endoscopy (2019)

Radiation therapy plays an emerging role in the multi-modal treatment of locally advanced pancreatic cancer (LAPC). Stereotactic body radiation therapy (SBRT) is an innovative radiation technique, characterized by high prescription dose delivered in few fractions and increased local control rate. Endoscopic ultrasound (EUS)-guided fiducials placement allows to accurately evaluate the target motionduring SBRT delivery.
Endoscopic-ultrasound evaluation and fine needle aspiration with a linear echoendoscope in the cecum: it is possible
Authors: Spencer Cheng, Vitor Ottoboni Brunaldi, Gustavo Luis Rodela Silva, Carlos Kiyoshi Furuya, Mauricio Kazuyoshi Minata, Sergio Eiji Matuguma, Everson Luiz de Almeida Artifon
Journal: Endoscopy (2019)

Endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA) is central to the accurate diagnosis of subepithelial lesions. Similarly, staging of early neoplastic lesions is also an important step in deciding the best treatment option [1] [2]. Unfortunately, the oblique endoscopic view of the linear-array echoendoscope precludes routine cecal intubation. Therefore, EUS evaluation in the right colon and cecum is usually restricted to mini-probes and forward-view radial echoendoscopes, which do not allow tissue sampling [3]. We describe a new technique that allows a standard oblique-view linear-array echoendoscope to be used to intubate the cecum and perform EUS-FNA.
LYMPHOVASCULAR INFILTRATION IS A HIGH RISK FACTOR FOR LYMPH NODE METASTASIS INDEPENDENT OF DEPTH OF INVASION IN T1 COLORECTAL CANCERS
Authors: H Thorlacius, CF Rönnow, V Andersson, E Toth, I Syk
Journal: Endoscopy (2019)

Depth of submucosal invasion is commonly used to predict risk for lymph node metastasis in T1 colorectal cancers although published data are conflicting on the risk of metastasis in relation to level of submucosal growth. The aim of this study was to identify risk factors for lymph node metastasis in T1 colorectal cancers.