Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel
Authors: Brian W. Kunkle, Michael Schmidt, Hans-Ulrich Klein, Adam C. Naj, Kara L. Hamilton-Nelson, Eric B. Larson, Denis A. Evans, Phil L. De Jager, Paul K. Crane, Joe D. Buxbaum, Nilufer Ertekin-Taner, Lisa L. Barnes, M. Daniele Fallin, Jennifer J. Manly, Rodney C. P. Go, Thomas O. Obisesan, M. Ilyas Kamboh, David A. Bennett, Kathleen S. Hall, Alison M. Goate, Tatiana M. Foroud, Eden R. Martin, Li-San Wang, Goldie S. Byrd, Lindsay A. Farrer, Jonathan L. Haines, Gerard D. Schellenberg, Richard Mayeux, Margaret A. Pericak-Vance, Christiane Reitz, Erin Abner, Perrie, M. Adams, Roger, L. Albin, Liana, G. Apostolova, Steven, E. Arnold, Craig, S. Atwood, Clinton, T. Baldwin, Robert, C. Barber, Sandra Barral, Thomas, G. Beach, James, T. Becker, Gary, W. Beecham, Eileen, H. Bigio, Thomas, D. Bird, Deborah Blacker, Bradley, F. Boeve, James, D. Bowen, Adam Boxer, James, R. Burke, Jeffrey, M. Burns, Nigel, J. Cairns, Chuanhai Cao, Cynthia, M. Carlsson, Regina, M. Carney, Minerva, M. Carrasquillo, David, H. Cribbs, Carlos Cruchaga, Malcom Dick, Dennis, W. Dickson, Rachelle S. Doody, Ranjan Duara, Kelley, M. Faber, Thomas, J. Fairchild, Kenneth, B. Fallon, David, W. Fardo, Martin, R. Farlow, Steven Ferris, Matthew, P. Frosch, Douglas, R. Galasko, Marla Gearing, Daniel, H. Geschwind, Bernardino Ghetti, John, R. Gilbert, Robert, C. Green, John, H. Growdon, Hakon Hakonarson, Ronald, L. Hamilton, John Hardy, Lindy, E. Harrell, Lawrence, S. Honig, Ryan, M. Huebinger, Matthew, J. Huentelman, Christine, M. Hulette, Gail, P. Jarvik, Lee-Way Jin, Anna Karydas, Mindy, J. Katz, John, S.K. Kauwe, C. Dirk Keene, Ronald Kim, Joel, H. Kramer, James, J. Lah, Yuk Ye Leung, Ge Li, Andrew, P. Lieberman, Richard, B. Lipton, Constantine, G. Lyketsos, John Malamon, Daniel, C. Marson, Frank Martiniuk, Eliezer Masliah, Wayne, C. McCormick, Susan, M. McCurry, Andrew, N. McDavid, Stefan McDonough, Ann, C. McKee, Marsel Mesulam, Bruce, L. Miller, Carol, A. Miller, Thomas, J. Montine, Shubhabrata Mukherjee, Amanda, J. Myers, Sid, E. O’Bryant, John, M. Olichney, Joseph, E. Parisi, Elaine Peskind, Aimee Pierce, Wayne, W. Poon, Huntington Potter, Liming Qu, Joseph, F. Quinn, Ashok Raj, Murray Raskind, Barry Reisberg, Joan, S. Reisch, John, M. Ringman, Erik, D. Roberson, Ekaterina Rogaeva, Howard, J. Rosen, Donald, R. Royall, Mark, A. Sager, Julie, A. Schneider, Lon, S. Schneider, William, W. Seeley, Scott Small, Joshua, A. Sonnen, Salvatore Spina, Peter St George-Hyslop, Robert, A. Stern, Rudolph, E. Tanzi, Juan, C. Troncoso, Debby, W. Tsuang, Otto Valladares, Vivianna, M. Van Deerlin, Badri, N. Vardarajan, Harry, V. Vinters, Jean Paul Vonsattel, Sandra Weintraub, Kathleen, A. Welsh-Bohmer, Kirk, C. Wilhelmsen, Jennifer Williamson, Thomas, S. Wingo, Randall, L. Woltjer, Chuang-Kuo Wu, Steven, G. Younkin, Lei Yu, Chang-En Yu, Yi Zhao, Neill R. Graff-Radford, Izri Martinez, Temitope Ayodele, Mark W. Logue, Laura B. Cantwell, Melissa Jean-Francois, Amanda B. Kuzma, L.D. Adams, Jeffery M. Vance, Michael L. Cuccaro, Jaeyoon Chung, Jesse Mez, Kathryn L. Lunetta, Gyungah R. Jun, Oscar L. Lopez, Hugh C. Hendrie, Eric M. Reiman, Neil W. Kowall, James B. Leverenz, Scott A. Small, Allan I. Levey, Todd E. Golde, Andrew J. Saykin, Takiyah D. Starks, Marilyn S. Albert, Bradley T. Hyman, Ronald C. Petersen, Mary Sano, Thomas Wisniewski, Robert Vassar, Jeffrey A. Kaye, Victor W. Henderson, Charles DeCarli, Frank M. LaFerla, James B. Brewer, Bruce L. Miller, Russell H. Swerdlow, Linda J. Van Eldik, Henry L. Paulson, John Q. Trojanowski, Helena C. Chui, Roger N. Rosenberg, Suzanne Craft, Thomas J. Grabowski, Sanjay Asthana, John C. Morris, Stephen M. Strittmatter, Walter A. Kukull
Journal: JAMA Neurology (2020)

Compared with non-Hispanic White individuals, African American individuals from the same community are approximately twice as likely to develop Alzheimer disease. Despite this disparity, the largest Alzheimer disease genome-wide association studies to date have been conducted in non-Hispanic White individuals. In the largest association analyses of Alzheimer disease in African American individuals, ABCA7, TREM2, and an intergenic locus at 5q35 were previously implicated.