tbuckley/cabot-search huggingface dataset:
Abstract 3: Kawasaki Disease in Algerian Children: A Clinical Study
Authors: Houda Boudiaf, Moussa Achir
Journal: Circulation (2015)

Background: Kawasaki disease (KD) is an acute multisystem vasculitis of unknown etiology that occurs predominantly in infants and young children. The incidence of KD is increasing worldwide ; however the epidemiological data available for Algerian patients remains insufficient Objective: To describe the demographic, clinical, and laboratory features of Algerian children with KD and to highlight the practical difficulties. Methods: This retrospective study included children admitted with Kawasaki disease at the only pediatric tertiary referral hospital in Algiers over a period of 8 years from January 2006 to December 2013. Results : 108 patients with KD, with a mean age of 31 months (range: 8-84 months)were identified. There were 63 boys and 45 girls (sex ratio: 1.4). The clinical data were similar to previously described studies, with some difference: the cervical lymphadenopathy was less frequent :25%(27/108). 22%( 24/108) of children had evidence of cardiac complications: 20%( 22/108) had coronary artery abnormalities ; one child had mitral regurgitation, one had pericardial effusion. Of the 22 children with coronary abnormalities , 9 had coronary dilatation, 13 had coronary aneurysms (10 small and medium, 3 giant). These abnormalities regressed in 13 cases on follow up. During this period, catheter and surgical coronary intervention were performed to treat coronary ischemia in one patient, two years after onset. The only independent variable for prediction of coronary involvement was fever duration at the time of initial presentation(p=0.016). The therapeutic used in this study included an immunoglobulin treatment for only 63%(69/108) of the children, half of which received it within the first ten days of the onset of the disease. Conclusion: This work demonstrates the necessity of a registry that will allow better appreciation of the incidence of this disease and improve the diagnosis and treatment of KD in Algeria
CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors
Authors: Robbie G. Majzner, Johanna L. Theruvath, Anandani Nellan, Sabine Heitzeneder, Yongzhi Cui, Christopher W. Mount, Skyler P. Rietberg, Miles H. Linde, Peng Xu, Christopher Rota, Elena Sotillo, Louai Labanieh, Daniel W. Lee, Rimas J. Orentas, Dimiter S. Dimitrov, Zhongyu Zhu, Brad St Croix, Alberto Delaidelli, Alla Sekunova, Ezio Bonvini, Siddhartha S. Mitra, Martha M. Quezado, Ravindra Majeti, Michelle Monje, Poul H.B. Sorensen, John M. Maris, Crystal L. Mackall
Journal: Clinical Cancer Research (2019)

Patients with relapsed pediatric solid tumors and CNS malignancies have few therapeutic options and frequently die of their disease. Chimeric antigen receptor (CAR) T cells have shown tremendous success in treating relapsed pediatric acute lymphoblastic leukemia, but this has not yet translated to treating solid tumors. This is partially due to a paucity of differentially expressed cell surface molecules on solid tumors that can be safely targeted. Here, we present B7-H3 (CD276) as a putative target for CAR T-cell therapy of pediatric solid tumors, including those arising in the central nervous system.
A Novel Risk-Model to Predict Time to First Treatment (TTT) in Chronic Lymphocytic Leukemia Based on Heavy+Light Chain Immunoparesis and Serum Free Light Chain Analysis: Results from the Israeli CLL Study Group
Authors: Tamar Tadmor, Andrei Braester, Najib Dally, Ariel Aviv, Yair Herishanu, Mona Yuklea, Lev Shvidel, Naomi Rahimi-Levene, Rosa Ruchlemer, Ariela Arad, Claudia Fogl, Aaron Polliack, Lee Magal, Kelly Townsend
Journal: Blood (2018)
SAT0657 Microwave radiometry-derived thermal changes of sacroiliac joints as a biomarker of sacroiliitis in patients with spondyloarthropathy
Authors: K. Laskari, D.A. Pitsilka, G. Pentazos, E. Siores, M.G. Tektonidou, P.P. Sfikakis
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Microwave Radiometry (MR) is a rapid, easy-to-perform, non-invasive method that detects in-depth tissue temperatures. In a proof-of-concept study we found that an increased knee joint temperature detected by MR reflects the presence of subclinical synovial inflammation in patients with rheumatoid arthritis.<sup>1</sup> <h3>Objectives</h3> To test the hypothesis that MR-derived increased temperature of sacroiliac (SI) joints is a biomarker of local inflammation in patients with axial spondyloarthritis (SpA) in a cross-sectional study. <h3>Methods</h3> Sixty patients with SpA (32 with ankylosing spondylitis, 24 with psoriatic arthritis, 4 with enteropathic arthritis) underwent clinical and laboratory assessments, magnetic resonance, X-ray imaging, and MR measurements of SI joints. All MR measurements were performed by a physician who was blinded to the clinical evaluations. Patients were classified as having active sacroiliitis (pain and/or tenderness and/or bone marrow oedema on magnetic resonance, n=23), inactive sacroiliitis (n=19), whereas signs/symptoms of a present/past SI joint involvement were absent in the remaining 18 patients. Twenty five age-matched healthy individuals served as controls. Three MR measurements were performed along each SI joint and a number was calculated for each patient denoting the difference (ΔΤ) in temperature between the warmest point in either SI joint and a control point, which was the iliac bone. <h3>Results</h3> A lower ΔΤ, indicative of a warmer joint, was found in patients with either active or inactive sacroiliitis compared to patients without sacroiliitis [mean (SD) ΔΤ of 0.1 (0.5) vs. 0.6 (0.5), respectively, p=0.001] or healthy controls [mean (SD) ΔΤ of 0.60 (0.55), p=0.003]. A warmer SI joint was not significantly associated with the presence of local tenderness or pain, the patient visualised analogue pain scale for SI joints, the BASDAI score, the New York radiological grading of SI lesions, or C-reactive protein levels. Notably, all 20 patients with increased SI joint temperature (ΔΤ&lt;0.05, which was the mean ΔΤ value minus one SD in healthy controls) had either symptoms/signs of sacroiliitis or imaging confirmed sacroiliitis even in the absence of clinical findings. Receiver operating analysis showed that a ΔΤ cut-off of 0.35 could discriminate with a sensitivity of 78% and specificity of 74% patients with sacroiliitis from those without, or from healthy controls (both p=0.001); sensitivity reached 100% for ΔΤ values equal or lower than 0.05. <h3>Conclusions</h3> MR-derived increased in-depth temperature indicative of local inflammation of SI joints may serve as an additional diagnostic marker in axial SpA <h3>Reference</h3> [1] Zampeli EI, et al. "Detection of subclinical synovial inflammation by microwave radiometry,"PLoS ONE2013May;8(5):e64606. <h3>Disclosure of Interest</h3> None declared
SP0009 Fibromyalgia onset of systemic lupus erythematosus?
Authors: N. Hassan
Journal: Annals of the Rheumatic Diseases (2018)

<h3></h3> Systemic lupus erythematosus (SLE) and fibromyalgia often pose a diagnostic challenge to clinicians. The two conditions can coexist and the presence of one can complicate the diagnosis and management of the other. There is an increased prevalence of fibromyalgia amongst SLE patients compared to the general population but the exact nature of this association is not yet fully understood. We describe a patient diagnosed with fibromyalgia who later went on to develop SLE. <h3>Disclosure of Interest</h3> None declared
Current challenges in the development of new treatments for lupus
Authors: Maria Dall'Era, Ian N Bruce, Caroline Gordon, Susan Manzi, Janis McCaffrey, Peter E Lipsky
Journal: Annals of the Rheumatic Diseases (2019)

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a considerable impact on patients’ quality of life. Despite the plethora of clinical trials for SLE since the turn of the millennium, only one new treatment has been approved for the condition, and the overall pace of successful drug development remains slow. Nevertheless, the myriad of clinical studies has yielded insights that have informed and refined our understanding of eligibility criteria, outcome measures and trial design in SLE. In this review, we highlight the achievements of clinical trials as well as the major pitfalls that have been identified in drug development for SLE and, in doing so, identify areas where collaboration and consensus will be important to facilitate progress.
Derek Tacchi: gynaecologist who pioneered laparoscopic surgery
Authors: Matt Limb
Journal: BMJ (2019)

Derek Tacchi was a consultant obstetrician and gynaecologist who advanced his specialty as a doctor, scholar, teacher, administrator, and early adopter of diagnostic innovations. He introduced laparoscopy into clinical practice in the north east of England in the early 1960s and successfully embraced evidence based medicine before it became commonplace, say friends. He also made important contributions to the study of gynaecological and fertility problems and produced a definitive modern history of childbirth in Newcastle upon Tyne.

From 1962 to 1991, Tacchi was a consultant obstetrician and gynaecologist at the Royal Victoria Infirmary, in Newcastle upon Tyne, and lecturer at Newcastle University.

“The introduction of the laparoscope was very slow in some areas in the early 1960s,” says John Davison, who studied under Tacchi and went on to become a professor in obstetric medicine at Newcastle University. “Derek had foresight and saw the wisdom of using it. He knew he had to be involved in laparoscopy and he searched out who he …
Unraveling the Mechanobiology of the Immune System
Authors: Jeong‐Ki Kim, Yu Jung Shin, Leslie Jaesun Ha, Deok‐Ho Kim, Dong‐Hwee Kim
Journal: Advanced Healthcare Materials (2019)

Abstract Cells respond and actively adapt to environmental cues in the form of mechanical stimuli. This extends to immune cells and their critical role in the maintenance of tissue homeostasis. Multiple recent studies have begun illuminating underlying mechanisms of mechanosensation in modulating immune cell phenotypes. Since the extracellular microenvironment is critical to modify cellular physiology that ultimately determines the functionality of the cell, understanding the interactions between immune cells and their microenvironment is necessary. This review focuses on mechanoregulation of immune responses mediated by macrophages, dendritic cells, and T cells, in the context of modern mechanobiology.
AB1355 Bone mineral density, t-score and z-score in young men with juvenile idiopathic arthritis
Authors: V. Povoroznyuk, M. Dzhus
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Juvenile Idiopathic Arthritis (JIA) is term used to classify a group of heterogeneous paediatric rheumatic diseases. Many of these conditions remain active until adulthood. Presences of chronic inflammatory disease together with glucocorticoid treatment are the risk factors of development of osteoporosis in young adult males. <h3>Objectives</h3> <b>Aim</b>: to study the bone mineral density (BMD), T-score, Z-score in young adult males with JIA. <h3>Methods</h3> The study included 50 adult men aged 19 to 25 years, divided into two groups: I – 25 practically healthy young males; II – 25 young men from different regions of Ukraine with a history of JIA in childhood regardless of the presence or absence of active inflammation at the time of the observation. Two-energy X-ray densitometry (Prodigy, GE Lunar, Madison, USA) was performed on the basis of the Institute of Gerontology, Ukrainian Research Centre of Osteoporosis Problems with analysis of BMD, T- and Z-scores in different skeletal areas. <h3>Results</h3> Young men with JIA and healthy individuals did not differ in age, height, weight and BMI. In assessing the number of fractures in patients with JIA were identified 4 patients (16%), while in the control group were no fractures. negative impact of the JIA on the BMD was found in the I group compared with II group. Lumbar spine BMD in I group was lower (p&lt;0.01) than in healthy subjects, as well as the Z-score (p&lt;0.001) in the L1-L4 lumbar spine region. BMD, T-score and Z-score in femoral neck region were lower in I group than in II (p&lt;0.001, p&lt;0.001, p&lt;0.01 corresponding). Reliable differences between the two groups were found in total body BMD (p&lt;0,001), T-score (p&lt;0.01), Z-score (p&lt;0.05). Patients with JIA had lower (p&lt;0.01) BMD and T-score (p&lt;0.05) in ultradistal area of forearm. Reduction of BMD up to the level of osteopenia (Z-score &lt;2 SD) was found in 5 out of 25 (20%) patients at the level of L1-L4 lumbar spine, in 2 (8%) patients at the level of femoral neck, in 3 (12%) patients at total body and in 2 (8%) patients at the level of ultradistal area of forearm. <h3>Conclusions</h3> Young men with JIA aged 19–25 years had reduced total body BMD, T-score, Z-score, which indicates the negative impact of the disease on the bone tissue compared with healthy men of the corresponding age. <h3>Disclosure of Interest</h3> None declared
THU0406 Iv cyclophosphamide vs. rituximab for the treatment of early diffuse scleroderma lung disease: open label, randomised, controlled trial
Authors: G. Sircar, R.P. Goswami, D. Sircar, D. Rath, S. Mondal, P.S. Mahapatra, A. Ghosh, P. Ghosh
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Systemic sclerosis is characterised by fibrotic changes in the skin and lung, and the mainstay of treatment has been cyclophosphamide. B cell involvement suggests that rituximab may also be of therapeutic benefit. In this study, we compared the safety and efficacy of rituximab compared to cyclophosphamide in the treatment of skin and lung manifestations of systemic sclerosis. <h3>Objectives</h3> The aims of the study were to assess the efficacy and safety of IV Rituximab compared to IV cyclophopsphamide in the primary therapy of systemic sclerosis, with particular emphasis on pulmonary and dermatological manifestations. <h3>Methods</h3> We randomly assigned 60 patients of systemic sclerosis, age 18–70 years with skin and lung involvement, to monthly pulses of cyclophosphamide 500 mg/sq. m or rituximab 1000 mg x 2 doses at 0, 15 days. Primary outcomes were forced vital capacity (FVC) percent predicted at six months. Secondary outcomes were: absolute change in litres (FVC-L) at six months; modified Rodnan Skin Scores at 6 months, six-minute walk test (6MWT), and Medsgers score <h3>Results</h3> The FVC (%mean ±SD) in Rituximab group improved from 61.30 (±11.28) to 67.52 (±13.59) while in Cyclophosphamide group, it declined from 59.25 (±12.96) to 58.06 (±11.23) at 6 months (p 0.003). The change of FVC was 1.51 (±0.45) L to 1.65 (±0.47) L in Rituximab group compared to 1.42 (±0.49) to 1.42 (±0.46) L in Cyclophosphamide group. The mRSS changed from 21.77 (±9.86) to 12.10 (±10.14) in RTX group and 23.83 (±9.28) to 18.33 (±7.69) in Cyclophosphamide group after 6 months. Serious adverse events were more common in the cyclophosphamide group. <h3>Conclusions</h3> Rituximab is a safe and effective alternative to cyclophosphamide in the primary therapy of skin and lung manifestations of scleroderma. <h3>Disclosure of Interest</h3> None declared
THU0295 Factors associated with patient-physician discordance in a prospective cohort of patients with psoriatic arthritis: an asian perspective
Authors: C. Wang, Y.H. Kwan, W. Fong, S.Q. Xiong, Y.Y. Leung
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Psoriatic arthritis (PsA) is a chronic inflammatory articular disease with diverse clinical manifestations. Few biomarkers are available to assess disease activity in PsA. Hence, both the patient's and the physician's assessment of disease activity is vital in ensuring optimal treatment outcomes. Understanding factors associated with patient and physician discordance can facilitate shared decision making and treatment management between patient and physician. There is limited data on factors associated with patient and physician discordance in psoriatic arthritis; none of which exist in the Asian population. <h3>Objectives</h3> To identify the factors associated with patient-physician discordance in a multi-ethnic Asian cohort of Psoriatic arthritis (PsA) patients. <h3>Methods</h3> Data was obtained from a prospective cohort of consecutive patients with psoriatic arthritis, who fulfil the CASPAR criteria recruited from a single centre in Singapore. Sociodemographic, clinical data and patient reported outcomes were collected using a standardised protocol at baseline, 4 months, 8 months, 1 year and 2 years. Patient-physician discordance was defined as patient global assessment minus physician global assessment (PGA - PhGA). We evaluated factors associated with patient-physician using generalised linear regression to control for within-subject effect. <h3>Results</h3> From 126 patients (50.4% male, 67.5% Chinese, age: 51±13.8 years, duration of illness: 5.6±6.1 years) recruited at baseline, paired data for patient and physician global assessments were available for 224 visits over a median follow up of 10 (range 0–15) months. In univariable analysis, gender, duration of illness, fatigue, pain score, number of tender joint/swollen joint/dactylitis, mental health subscale of SF36 and physical function by Health Assessment Questionnaire (HAQ) were significantly associated with patient-physician discordance. In multivariable analysis, higher level of fatigue, higher pain score, poorer mental health were associated with PGA-PhGA; while higher swollen joint and dactylitis count were negatively associated with PGA-PhGA (table 1). <h3>Reference</h3> [1] A Higher score represents poorer status <h3>Abbreviations</h3> HAQ: Physical function by Health Assessment Questionnaire; SF36: Medical Outcome Short Form 36 <h3>Conclusions</h3> Higher pain score, higher level of fatigue and poorer mental health may explain underestimation of patient global assessment by physicians. Higher swollen joint and dactylitis count may explain overestimation of physician global assessment. <h3>Disclosure of Interest</h3> None declared
Homeless people’s A&amp;E visits treble in seven years
Authors: Gareth Iacobucci
Journal: BMJ (2019)

The number of visits to hospital emergency departments by homeless people in England has almost trebled in seven years, an investigation by the BMA shows.1

The analysis found that the number of recorded visits to emergency departments by patients classed as having no fixed address rose from 11 305 in 2010-11 to 31 924 in 2017-18. The BMA also found that homeless patients were presenting with increasingly complex physical and mental health conditions. It said that cuts to health and social care budgets were driving the problem.

Among the hospital trusts with the …
AB0367 “the structural index score – sis” for rheumatoid foot and its relation to foot function, disability and physical performance tests
Authors: J.Z. Gaino, M.B. Bertolo, C.S. Nunes, C.M. Barbosa, Z. Sachetto, M. Davitt, E.D.P. Magalhães
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Feet are involved in 90%of Rheumatoid arthritis (RA) patients. The Structural Index Score(SIS) is a score that evaluates forefoot and rearfoot aspects. Although it has been used as a clinical tool to quantify foot deformities in RA, its relevance in clinical practice is uncertain. <h3>Objectives</h3> The aim of this study was to evaluate the relation of SIS with foot function, disability and physical performance tests in RA. <h3>Methods</h3> 104 RA patients of the outpatient clinic of Rheumatology/Unicamp were evaluated for SIS total, forefoot, rearfoot and its items (hallux valgus, metatarsalphalangeal (MTP) subluxation, 5th MTP exostosis, claw/hammer toe deformities, calcaneus varus/valgus angle, ankle range of motion (ARM) and planus/cavus foot deformity). Subjects also performed Foot Function Index-FFI, Health Assessment Questionnaire Disability Index-HAQ-DI, lower limb HAQ-LL-HAQ and physical tests: Berg Balance Scale-BBS, the Timed Up and Go-TUG and the 5-time sit down-to-stand up-SST5 tests.SIS items were compared with HAQ, LL-HAQ, FFI and physical tests through Kruskal- Wallis test and Spearman correlation coefficient with a 5% level of significance. <h3>Results</h3> SIS-Forefoot score did not correlate with any variables. Among the SIS-forefoot items, hallux valgus was associated with FFI-pain (p=0.007), FFI-disability(p=0.005)and FFI-total (p=0.016); MTP subluxation was weakly correlated with FFI-disability (r<sub>s</sub>=0.196) and 5th MTP exostosis was associated with FFI-pain(p=0.018). SIS-Total, SIS-Rearfoot and its associated and correlated items are shown in table 1. <h3>Conclusions</h3> It is not clear if the use of SIS may be related to function and disability in RA. Forefoot SIS did not show correlation although hallux valgus, MTP subluxation and 5th MTP exostosis may be related to foot function. Rearfoot SIS and its items seem to be most correlated with function and disability in RA. <h3>References</h3> [1] Kerry RH, et al. The foot in chronic rheumatoid arthritis:a continuing problem. The Foot1994;4:201–3. [2] Turner DE, et al. Biomechanics of the foot in rheumatoid arthritis:identifying abnormal function and the factors associated with localised disease'impact'.Clin Biomech2008;23(1):93–1003. [3] Platto MJ, et al. The relationship of pain and deformity of the rheumatoid foot to gait and an index of functional limitation. J Rheumatol1991;18:38–43. [4] Göksel Karatepe A, et al. Foot deformities in patients with rheumatoid arthritis: the relationship with foot functions. Int J Rheum Dis. 2010;13(2):158–63. <h3>Disclosure of Interest</h3> None declared
Microbiota Phylogenic Analysis Revealed Decreased Abundance of Faecalibacterium Prausnitzii, an Anti-Inflammatory Commensal Bacterium, in Patients with Chronic Graft-Versus-Host Disease
Authors: Nosha Farhadfar, Raad Z. Gharaibeh, John R. Wingard, Debra Lyon, Christian Jobin, Gary P Wang, Michael Raymond Weaver, Hemant S. Murthy, Debra Lynch Kelly
Journal: Blood (2018)
Abstract 13793: Finerenone Reduces Arterial Stiffness in Genetic Hypertensive Rat Model With Spontaneous Albuminuria
Authors: Marta Gil-Ortega, Elena Vega-Martín, Miriam Martin-Ramos, Raquel González-Blázquez, Angela Schulz, Luis Miguel Ruilope, Peter Kolkhof, Beatriz Somoza, Reinhold Kreutz, Maria S Fernandez-Alfonso
Journal: Circulation (2017)

Introduction: Several studies show the association between albuminuria and arterial stiffness in hypertensive and diabetic patients, as well as in the general population. In a genetic rat model wit...
The Relationship Between Air Pollution and Lung Cancer in Nonsmokers in Taiwan
Authors: Chien-Hua Tseng, Ben-Jei Tsuang, Chun-Ju Chiang, Kai-Chen Ku, Jeng-Sen Tseng, Tsung-Ying Yang, Kuo-Hsuan Hsu, Kun-Chieh Chen, Sung-Liang Yu, Wen-Chung Lee, Tsang-Wu Liu, Chang-Chuan Chan, Gee-Chen Chang
Journal: Journal of Thoracic Oncology (2019)
Genetic and transcriptional landscape of plasma cells in POEMS syndrome
Authors: Yuhei Nagao, Naoya Mimura, June Takeda, Kenichi Yoshida, Yusuke Shiozawa, Motohiko Oshima, Kazumasa Aoyama, Atsunori Saraya, Shuhei Koide, Ola Rizq, Yoshinori Hasegawa, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Dai Nishijima, Yusuke Isshiki, Kensuke Kayamori, Chika Kawajiri-Manako, Nagisa Oshima-Hasegawa, Shokichi Tsukamoto, Shio Mitsukawa, Yusuke Takeda, Chikako Ohwada, Masahiro Takeuchi, Tohru Iseki, Sonoko Misawa, Satoru Miyano, Osamu Ohara, Koutaro Yokote, Emiko Sakaida, Satoshi Kuwabara, Masashi Sanada, Atsushi Iwama, Seishi Ogawa, Chiaki Nakaseko
Journal: Leukemia (2019)