tbuckley/cabot-search huggingface dataset:
What is resilience: an affiliative neuroscience approach
Authors: Ruth Feldman
Journal: World Psychiatry (2020)

Resilience - a key topic in clinical science and practice - still lacks a clear conceptualization that integrates its evolutionary and human-specific features, refrains from exclusive focus on fear physiology, incorporates a developmental approach, and, most importantly, is not based on the negation (i.e., absence of symptoms following trauma). Building on the initial condition of mammals, whose brain matures in the context of the mother's body and caregiving behavior, we argue that systems and processes that participate in tuning the brain to the social ecology and adapting to its hardships mark the construct of resilience. These include the oxytocin system, the affiliative brain, and biobehavioral synchrony, all characterized by great flexibility across phylogenesis and ontogenesis. Three core features of resilience are outlined: plasticity, sociality and meaning. Mechanisms of sociality by which coordinated action supports diversity, endurance and adaptation are described across animal evolution. Humans' biobehavioral synchrony matures from maternal attuned behavior in the postpartum to adult-adult relationships of empathy, perspective-taking and intimacy, and extends from the mother-child relationship to other affiliative bonds throughout life, charting a fundamental trajectory in the development of resilience. Findings from three high-risk cohorts, each tapping a distinct disruption to maternal-infant bonding (prematurity, maternal depression, and early life stress/trauma), and followed from birth to adolescence/young adulthood, demonstrate how components of the neurobiology of affiliation confer resilience and uniquely shape the social brain.
Effect of Fructose on Body Weight in Controlled Feeding Trials
Authors: John L. Sievenpiper, Russell J. de Souza, Arash Mirrahimi, Matthew E. Yu, Amanda J. Carleton, Joseph Beyene, Laura Chiavaroli, Marco Di Buono, Alexandra L. Jenkins, Lawrence A. Leiter, Thomas M.S. Wolever, Cyril W.C. Kendall, David J.A. Jenkins
Journal: Annals of Internal Medicine (2012)

High levels of dietary fructose are implicated as an important contributor to obesity in developed countries. This systematic review of controlled feeding trials examined the effect of fructose on ...
PERCUTANEOUS ENDOSCOPIC GASTROSTOMY PLACEMENT - WHAT ARE THE RISK FACTORS FOR POOR OUTCOMES?
Authors: R Patel, R Cama, S Moledina, K Besherdas
Journal: Endoscopy (2020)

Aims Percutaneous endoscopic gastrostomy (PEG) is a relatively safe well-established procedure to permit long term enteral feeding in patients with swallowing difficulties. However, there is a significant procedure-related and all-cause mortality risk. Controversy still remains regarding patient selection and optimal timing for the procedure. We aimed to identify risk factors associated with length of stay and mortality following PEG placement.
Delivery of Talc for Pleurodesis of Malignant Pleural Effusions—Reply
Authors: Rahul Bhatnagar, Nick A. Maskell
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MARROW TRANSPLANTATION FROM UNRELATED VOLUNTEER DONORS
Authors: Claudio Anasetti, M.D, Ruth Etzioni, Ph.D, Effie W. Petersdorf, M.D, Paul J. Martin, M.D, John A. Hansen, M.D
Journal: Annual Review of Medicine (1995)

▪ Abstract Marrow transplants from human leukocyte antigen (HLA)-compatible unrelated volunteer donors have become feasible for more than 30% of patients without a family match and have allowed long-term, disease-free survival in 15–65% of patients with a variety of hematological disorders. However, unrelated donor transplants have a higher incidence of graft failure and graft versus host disease (GVHD) than do HLA-matched sibling transplants. This increase may be due to disparities between donor and recipient for undetected HLA determinants or for non-HLA histocompatibility genes. Because of the large number of HLA loci and their high degree of polymorphism, fully compatible donors will not be found for most patients. Fortunately, a limited degree of HLA mismatch does not necessarily impair long-term survival in patients with hematologic malignancy. Current studies are defining the risk associated with mismatching for each histocompatibility locus and are developing methods for marrow transplantation that can decrease morbidity and improve survival despite genetic disparity between donor and recipient.
POLYPS REFERRED TO EXPERT CENTER FOR POLYPECTOMY ACCORDING TO ENDOSCOPIST’S SPECIALTY
Authors: B Majcher, D Penz, E Kammerlander-Waldmann, A Hinterberger, A Szymanska, A Asaturi, M Trauner, M Ferlitsch
Journal: Endoscopy (2020)

Aims The ESGE-Guideline for colorectal polypectomy (Ferlitsch M et al.) recommends which polyps should be referred to expert centers for polypectomy. Not much is known about these polyps referred to tertiary centers. Therefore,our aim of the study was to assess rates of referred polyps according to endoscopist’s specialty.
ENDOSCOPIC VACUUM THERAPY EFFECTIVENESS IN PATIENTS WITH ESOPHAGEAL FISTULAE
Authors: A Denisova, P Zhegalov, A Samoylenko, V Melkomukov
Journal: Endoscopy (2020)

Aims Anastomotic leakage, esophageal wall perforation in Boerhaave syndrome or complications after endoscopic procedures are severe life threatening conditions and are not a very rare situation in clinical practice. Usage of endoscopic vacuum therapy (EVT) showed its effectiveness in treatment of esophageal defects of different origin. The aim of the study was to summarize our experience and to assess effectiveness of EVT in daily clinical practice in patients with esophageal fistulas including postoperative and postendoscopic leakages.
INTEROBSERVER AGREEMENT BETWEEN TUTOR AND FELLOW AFTER 6 MONTHS OF TRAINING IN ENDOSCOPIC ULTRASOUND
Authors: E Dabizzi, S Landi, M Bassi, S Ghersi, M Riccò, V Cennamo
Journal: Endoscopy (2020)

Aims Learning curve in Endoscopic Ultrasound (EUS) is extremely variable between operators and competence cannot be assessed just by the number of procedures performed. Interobserver agreement between trainees and tutors could be a reliable first step parameter to evaluate acquired skills during the training.
Underwater- Versus Conventional Endoscopic Mucosal Resection of Large Sessile or Flat Colonic Polyps: Results of a Prospective Randomized Controlled Trial
Authors: S Nagl, A Ebigbo, SK Goelder, L Neuhaus, C Roemmele, T Weber, G Braun, A Probst, E Schnoy, H Messmann
Journal: Endoscopy (2021)

Aims Conventional endoscopic mucosal resection (CEMR) with submucosal injection is the current standard for the resection of large,non-malignant colonic polyps. Underwater EMR (UEMR) has been shown to be more effective regarding R0 resection than CEMR for small and intermediate size colonic polyps. In this study we prospectively investigated whether UEMR is also superior to CEMR for large sessile or flat colonic polyps between 20 mm and 40 mm.
Bronchial thermoplasty - persistence of benefits out to 5 years in patients with severe asthma
Authors: G P Cox, M Laviolette, R Olivenstein, P Shah, R Niven, N Thomson, I D Pavord, A S Rubin, J Fiterman, Lapa, M E Wechsler, J B Hales, K Sumino, N S Shargill, B Armstrong, M Castro, Grp Ats.
Journal: Allergy (2013)
DUODENAL UNDERWATER ENDOSCOPIC MUCOSAL RESECTION IS SAFE AND EFFECTIVE FOR REMOVAL OF NON AMPULLARY DUODENAL TUMORS
Authors: D Kang, S Kim, HW Kim, S Park, JW Lee
Journal: Endoscopy (2020)

Aims Conventional endoscopic mucosal resection (EMR) and endoscopic submucosal dissection have been reported to be an effective therapeutic option in sporadic non ampullary duodenal tumors, but the rate of perforation is higher than that of other gastrointestinal lesion. A retrograde cohort study to investigate the effectiveness of underwater EMR (UW-EMR) was conducted in patients with nonampullary duodenal tumors.
CLINICAL OUTCOMES OF ENDOSCOPIC SUBMUCOSAL DISSECTION FOR RECTAL TUMORS EXTENDING TO THE DENTATE LINE
Authors: C Félix, P Barreiro, R Mendo, I Pereira, JA Rodrigues, C Chagas
Journal: Endoscopy (2020)

Aims Endoscopic submucosal dissection (ESD) is a well-established and widely accepted resection technique for colorectal lesions. However, the endoscopic excision of lesions extending to the dentate line involves specific difficulties related to the particular anatomical features of the anorectum. As a result, current guidelines give no recommendations on the ideal treatment strategy for these lesions. This study aimed to evaluate the efficacy and safety of ESD for the treatment of rectal tumor extending to the dentate line.
Man with chest wall mass and hypotension
Authors: Che-Yu Guan, Cheng-Hsuan Ho, Yi-Jhih Huang, Hong-Hau Wang, Ying-Yi Chen, Chia-Hsin Liu
Journal: Thorax (2020)

A 59-year-old man with a history of encephalopathy in bedridden state since childhood presented to our hospital with a left-sided enlarging chest wall mass of a 2-month duration. On physical examination, his vital signs were as follows: temperature, 35.8°C; pulse rate, 54/min; respiratory rate, 28/min; and blood pressure, 79/39 mm Hg. He displayed a tender, erythematous, fluctuant mass (9×8 cm) over the left anterior chest (figure 1A) and tenderness in the left upper quadrant. Moreover, poor dentition was noted. The laboratory studies showed leucocytosis (17.5×109/L) with predominant neutrophil count (88%) and elevated C-reactive protein level (164.8 mg/L). Chest radiography revealed an opacification extending from left lower lung field to left subphrenic region and blurred left costophrenic angle (figure 1B). Ultrasonography of the chest wall mass presented fluid collections with the communication between the chest wall and the pleural cavity …
Assessment of Prediagnostic Experiences of Black Women With Endometrial Cancer in the United States
Authors: Kemi M. Doll, Bridgette Hempstead, Julianna Alson, Liz Sage, Danielle Lavallee
Journal: JAMA Network Open (2020)

<h3>Importance</h3> Black women with endometrial cancer have a 90% higher mortality rate than white women with endometrial cancer. The advanced disease stage at which black women receive a diagnosis of endometrial cancer is a major factor in this disparity and is not explained by differences in health care access. <h3>Objective</h3> To describe the prediagnostic experiences of symptoms and symptom disclosure among black women with endometrial cancer. <h3>Design, Setting, and Participants</h3> This community-engaged qualitative study developed an interview guide to collect data during semistructured interviews among a sample of 15 black women with endometrial cancer in the United States. Interviews were conducted in person or via a secure conferencing platform. An exploratory and descriptive content analysis was performed using iterative rounds of inductive coding, case summaries, and coanalysis with community input to identify emergent themes. Data were collected from October 3, 2017, to April 15, 2019, and the descriptive content analysis was performed from October 11, 2017, to May 6, 2019. <h3>Main Outcomes and Measures</h3> Beliefs, interpretations, and experiences of black women with endometrial cancer from symptom onset to diagnostic confirmation of cancer. <h3>Results</h3> Participants included 15 women who self-identified as black or African American and ranged in age from 31 to 72 years. Eight participants lived in the Puget Sound region of Washington, 2 participants lived in California, and 1 participant each lived in Alabama, Michigan, Louisiana, Georgia, and New York. Twelve participants were receiving adjuvant therapy during the study, which indicated that they were either in a high-risk group and/or had advanced-stage disease. Thirteen participants had health insurance at the time of symptom onset, and all participants had elected to receive cancer treatment. Participants described knowledge gaps and silence about menopause, misinterpretation of vaginal bleeding, and responses by first-line health care practitioners that were not aligned with the risk of endometrial cancer among black women in the United States. <h3>Conclusions and Relevance</h3> The responses of interviewed black women with endometrial cancer suggest that several mechanisms may be associated with a delay in care before diagnosis among this high-risk population and represent modifiable factors that may be useful in the development of targeted interventions to improve the rates of early diagnosis among black women with endometrial cancer.
Smoking and Lung Cancer Mortality in the United States From 2015 to 2065
Authors: Jihyoun Jeon, Theodore R. Holford, David T. Levy, Eric J. Feuer, Pianpian Cao, Jamie Tam, Lauren Clarke, John Clarke, Chung Yin Kong, Rafael Meza
Journal: Annals of Internal Medicine (2018)

Although lung cancer mortality has decreased since the 1990s, lung cancer remains the leading cause of cancer death in the United States. This study used 4 simulation models of the natural history ...
RISK FACTORS FOR ENDOSCOPICALLY SEVERE ISCHEMIC COLITIS (IC)
Authors: SM Milluzzo, G DeMarco, P Cesaro, N Olivari, P Terragnoli, C Hassan, C Spada
Journal: Endoscopy (2020)

Aims IC is a relatively common disease caused by a transient colonic hypoperfusion. Aims of this study were to identify risk factors for endoscopic severity, and show epidemiology, clinical presentation, endoscopic findings and outcomes of IC.
TRENDS IN PEPTIC ULCER DISEASE: IS PEPTIC ULCER DISEASE SLOWLY DISAPPEAR?
Authors: V Milivojevic, I Rankovic, A Vojinovic, I Jovanovic, M Krstic, T Milosavljevic
Journal: Endoscopy (2020)

Aims To show the trends in the prevalence of peptic ulcer disease in uninvestigated dyspeptic patients in 2005. and 2015. year in Serbia
THE NEW GENERATION OF EXPRESS VIEW IS HIGHLY ACCURATE AND IS EFFECTIVE TO REDUCE CAPSULE ENDOSCOPY READING TIME
Authors: S Piccirelli, A Mussetto, A Bellumat, R Cannizzaro, M Pennazio, A Pezzoli, A Bizzotto, N Fusetti, F Valiante, C Spada
Journal: Endoscopy (2020)

Aims Capsule Endoscopy (CE) is a first-line diagnostic test in patients with suspected small bowel bleeding (SSBB). Since CE reading is time-consuming, innovative types of reading software have been developed. The new generation reading algorithm ‘Express-View’(EV) by MiroCam aims to reduce CE reading time by removing images based upon their similarity, without affecting the diagnostic yield.
THE PREVALENCE OF SMALL BOWEL POLYPS ON VIDEO CAPSULE ENDOSCOPY IN PATIENTS WITH SPORADIC DUODENAL AND/OR AMPULLARY ADENOMAS
Authors: H Awadie, A Klein, D Tate, B Jideh, I Bar Yishay, K Goodrick, G Ahlenstiel, MJ Bourke
Journal: Endoscopy (2020)

Aims Sporadic duodenal and/or ampullary adenomas (DA) are found in 1-3% of patients referred to upper endoscopy. Patients with duodenal adenomas have a 3-7-fold increased risk of colonic neoplasia. It is unknown whether DA patients have a clinically significant increased risk of small bowel neoplasia. Our aim was to investigate the prevalence of SB polyps occurring in association with large (≥10mm) DA patients using VCE.
Lithium Use in Pregnancy and the Risk of Cardiac Malformations
Authors: Elisabetta Patorno, Krista F Huybrechts, Sonia Hernandez-Diaz
Journal: New England Journal of Medicine (2017)

To the Editor: Patorno et al. (June 8 issue) 1 provided information on the risk of cardiac malformation in infants exposed to lithium during the first trimester of pregnancy.The risk is higher than in nonexposed infants or in infants exposed to lamotrigine, but the association is of a smaller magnitude than previously reported.We emphasize that these findings do not imply or support the idea that lithium treatment should be discontinued in women who are pregnant or planning a pregnancy or that lithium treatment should be avoided in women of childbearing age.If properly managed, lithium is the most effective prophylactic treatment option for bipolar disorder, both in and outside the perinatal period, and it has a side-effect profile that is more favorable than usually assumed. 2,3The increased risk of cardiac malformation presented in this research needs to be weighed against the high risk of a postpartum recurrence of bipolar disorder in women who do not receive treatment (in a recent meta-analysis, the risk was found to be 66% [95% confidence interval, 57 to 75] 4 ), as well as against the risks associated with alternative perinatal treatment options, such as lamotrigine 3 or the combined use of antipsychotics and antidepressants. 5
MANAGEMENT OF STENT REOBSTRUCTION IN PATIENTS WITH DISTAL MALIGNANT BILIARY OBSTRUCTION: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: A Tringali, F Pozzato, E Piovesana, A Graziotto, M Rinaldi, D Adler
Journal: Endoscopy (2020)

Aims Covered or uncovered self-expandable metallic stents (SEMS) placed in patients with malignant biliary obstruction (MBO) can occlude in 19-40%, but optimal management is unclear. However data suggest that the higher cost of an initial SEMS may be mitigated by the reduced need for repeated ERCP . We summarize the current evidence regarding management of occluded SEMS in patients with malignant biliary obstruction
Preclinical and Dose-Finding Phase I Trial Results of Combined Treatment with a TORC1/2 Inhibitor (TAK-228) and Aurora A Kinase Inhibitor (Alisertib) in Solid Tumors
Authors: S. Lindsey Davis, Anastasia A. Ionkina, Stacey M. Bagby, James D. Orth, Brian Gittleman, Joshua M. Marcus, Elaine T. Lam, Bradley R. Corr, Cindy L. O'Bryant, Ashley E. Glode, Aik-Choon Tan, Jihye Kim, John J. Tentler, Anna Capasso, Kyrie L. Lopez, Daniel L. Gustafson, Wells A. Messersmith, Stephen Leong, S. Gail Eckhardt, Todd M. Pitts, Jennifer R. Diamond
Journal: Clinical Cancer Research (2020)

Abstract Purpose: The purpose of this study was to evaluate the rational combination of TORC1/2 inhibitor TAK-228 and Aurora A kinase inhibitor alisertib in preclinical models of triple-negative breast cancer (TNBC) and to conduct a phase I dose escalation trial in patients with advanced solid tumors. Experimental Design: TNBC cell lines and patient-derived xenograft (PDX) models were treated with alisertib, TAK-228, or the combination and evaluated for changes in proliferation, cell cycle, mTOR pathway modulation, and terminal cellular fate, including apoptosis and senescence. A phase I clinical trial was conducted in patients with advanced solid tumors treated with escalating doses of alisertib and TAK-228 using a 3+3 design to determine the maximum tolerated dose (MTD). Results: The combination of TAK-228 and alisertib resulted in decreased proliferation and cell-cycle arrest in TNBC cell lines. Treatment of TNBC PDX models resulted in significant tumor growth inhibition and increased apoptosis with the combination. In the phase I dose escalation study, 18 patients with refractory solid tumors were enrolled. The MTD was alisertib 30 mg b.i.d. days 1 to 7 of a 21-day cycle and TAK-228 2 mg daily, continuous dosing. The most common treatment-related adverse events were neutropenia, fatigue, nausea, rash, mucositis, and alopecia. Conclusions: The addition of TAK-228 to alisertib potentiates the antitumor activity of alisertib in vivo, resulting in increased cell death and apoptosis. The combination is tolerable in patients with advanced solid tumors and should be evaluated further in expansion cohorts with additional pharmacodynamic assessment.
View From the COVID Palliative Care Unit
Authors: Alexis Drutchas
Journal: Annals of Internal Medicine (2020)

Ad Libitum4 August 2020View From the COVID Palliative Care UnitFREEAlexis Drutchas, MDAlexis Drutchas, MDMassachusetts General Hospital, Boston, Massachusetts (A.D.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M20-2883 Audio Reading - “View From the COVID Palliative Care Unit” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “View From the COVID Palliative Care Unit” by Alexis Drutchas, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I.Tired cobblestone slick with spring blossomsgray and gold rooftops dapple the view,our collective refuge has left the city quiet, still—I count passing cars plus one lonely planeon my hand, but the ambulance bay fillswith too many to ever know or nameCrayon art taped to the unit door fluttersglimpsing the pale face of a new patientone sign says, “Never Be Afraid!”II.To my right, a nurse bends her mask's bowmoving slowly, she exhales, testingher eyes closed like a prayerDown the hall my patient says goodbyeon Zoom. I love you, he reaches out—my gloved hand clutches hisBy sunrise his room is sterile again,the lingering smell of bleach and starched sheetsunsettles me all dayIII.This pandemic is taking something from us,(in truth I know it's also giving), but the full sumslips now through my fingersYesterday, a boy racing his bike yelled,“This is the best day EVER!” his living crisp and sky blueI pause, restraining my rage at this coin flip—Look, how close we all are in communal breathliving under these gray and gold rooftops,separated by the hush of our mourning air. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: Massachusetts General Hospital, Boston, Massachusetts (A.D.)Current Author Address: Alexis Drutchas, MD; e-mail, [email protected]harvard.edu.This article was published at Annals.org on 19 May 2020. PreviousarticleNextarticle Advertisement Audio Reading - “View From the COVID Palliative Care Unit” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “View From the COVID Palliative Care Unit” by Alexis Drutchas, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 4 August 2020Volume 173, Issue 3Page: 252KeywordsAmbulancesNursesPalliative carePatient advocacySmell ePublished: 19 May 2020 Issue Published: 4 August 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...