tbuckley/cabot-search huggingface dataset:
Abstract 17686: The Association Between Physical Activity Intensity and Left Atrial Size Among Healthy Adults: The Cooper Center Longitudinal Study
Authors: Douglas J Darden, Ambarish Pandey, Colby Ayers, Nina Radford, Laura DeFina, Benjamin Willis, Carolyn Barlow, Jarett D Berry
Journal: Circulation (2015)

Introduction: Increased left atrial (LA) volume has been proposed as a mechanism through which high levels of physical activity (PA) might increase the risk for atrial fibrillation (AF). However, the relationship between the intensity of PA and LA volume has not been previously reported. We hypothesized that vigorous activity would be more strongly associated with LA volume when compared to moderate PA. Methods: We included 1,641 healthy participants (age 55.6 years, 53.4% men) from the echocardiography substudy of the Cooper Center Longitudinal Study who were free of cardiovascular disease. PA was measured by self-report questionnaire that quantified the amount of moderate and vigorous PA performed in mins per week. LA volume was measured by 2D echocardiography using the biplane area-length method. The association between PA and LA volume indexed to body surface area was estimated using multivariable linear regression models with LA volume as the dependent variable and total, moderate, and vigorous activity (in min/per week) as the independent variables. Models were additionally adjusted for age, body mass index (BMI), hypertension, diabetes, and fitness. Results: Average levels of moderate, vigorous, and total PA in the study sample were 111, 103 and 191 min/week, respectively, with 68% of participants reporting some level of PA. As expected, higher levels of PA were associated with a lower BMI, lower blood pressure, and lower diabetes prevalence (p&lt;.05 for all). In multivariable adjusted models, age, fitness, BMI and higher vigorous activity were associated with a larger LA size. However, there was no apparent association between moderate PA and LA size (see table). Conclusion: Higher vigorous but not moderate PA was associated with a larger LA size. These data suggest that lower intensity exercise prescriptions might be preferred in clinical circumstances marked by concern for AF risk.
TCT-545 Development and Validation of a Prediction Rule for Transfusion in Patients Undergoing Percutaneous Coronary Intervention Using Administrative Clinical Parameters: A Korean Nationwide Longitudinal Cohort Study
Authors: Jin-Ho Choi, Jung Min Choi, Seung Hwa Lee, Joo Myung Lee, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Sang-Hoon Lee
Journal: Journal of the American College of Cardiology (2019)
TCT-711 Prevalence and Clinical Impact of Bioprosthesis Thrombosis After Transcatheter Aortic Valve Implantation. A Collaborative Meta-Analysis
Authors: Tobias Rheude, Costanza Pellegrini, Stefan Stortecky, Erion Xhepa, Hector Alvarez, Fabian Ammon, Thomas Pilgrim, Adnan Kastrati, Salvatore Cassese, Michael Joner
Journal: Journal of the American College of Cardiology (2019)
TCT-179 The Influence of Increasing Stent Length on Outcomes in Absorb BVS or Xience EES-Treated Patients in Routine Clinical PCI Practice: AIDA Trial Substudy
Authors: Ruben Tijssen, Kuniaki Takahashi, Laura Kerkmeijer, Norihiro Kogame, Yuki Katagiri, Ply Chichareon, Rodrigo Modolo, Jan Piek, Jan Tijssen, Jose P.S. Henriques, Robert de Winter, Yoshinobu Onuma, Patrick Serruys, Joanna Wykrzykowska
Journal: Journal of the American College of Cardiology (2019)
Non-Hodgkin’s Lymphomas
Authors: Andrew D. Zelenetz, Jeremy S. Abramson, Ranjana H. Advani, C. Babis Andreadis, John C. Byrd, Myron S. Czuczman, Luis Fayad, Andres Forero, Martha J. Glenn, Jon P. Gockerman, Leo I. Gordon, Nancy Lee Harris, Richard T. Hoppe, Steven M. Horwitz, Mark S. Kaminski, Youn H. Kim, Ann S. LaCasce, Tariq I. Mughal, Auyporn Nademanee, Pierluigi Porcu, Oliver Press, Leonard Prosnitz, Nashitha Reddy, Mitchell R. Smith, Lubomir Sokol, Lode Swinnen, Julie M. Vose, William G. Wierda, Joachim Yahalom, Furhan Yunus
Journal: Journal of the National Comprehensive Cancer Network (2010)
Dominant mutations in mtDNA maintenance gene SSBP1 cause optic atrophy and foveopathy
Authors: Camille Piro-Mégy, Emmanuelle Sarzi, Aleix Tarrés-Solé, Marie Péquignot, Fenna Hensen, Mélanie Quilès, Gaël Manes, Arka Chakraborty, Audrey Sénéchal, Béatrice Bocquet, Chantal Cazevieille, Agathe Roubertie, Agnès Müller, Majida Charif, David Goudenège, Guy Lenaers, Helmut Wilhelm, Ulrich Kellner, Nicole Weisschuh, Bernd Wissinger, Xavier Zanlonghi, Christian Hamel, Johannes N. Spelbrink, Maria Sola, Cécile Delettre
Journal: Journal of Clinical Investigation (2019)

Mutations in genes encoding components of the mitochondrial DNA (mtDNA) replication machinery cause mtDNA depletion syndromes (MDSs), which associate ocular features with severe neurological syndromes. Here, we identified heterozygous missense mutations in single-strand binding protein 1 (SSBP1) in 5 unrelated families, leading to the R38Q and R107Q amino acid changes in the mitochondrial single-stranded DNA-binding protein, a crucial protein involved in mtDNA replication. All affected individuals presented optic atrophy, associated with foveopathy in half of the cases. To uncover the structural features underlying SSBP1 mutations, we determined a revised SSBP1 crystal structure. Structural analysis suggested that both mutations affect dimer interactions and presumably distort the DNA-binding region. Using patient fibroblasts, we validated that the R38Q variant destabilizes SSBP1 dimer/tetramer formation, affects mtDNA replication, and induces mtDNA depletion. Our study showing that mutations in SSBP1 cause a form of dominant optic atrophy frequently accompanied with foveopathy brings insights into mtDNA maintenance disorders.
Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H
Authors: Fu Gui, Yuebo Zhang, Jianhua Wan, Xianbao Zhan, Yao Yao, Yinghua Li, Ashley N. Haddock, Ji Shi, Jia Guo, Jiaxiang Chen, Xiaohui Zhu, Brandy H. Edenfield, Lu Zhuang, Cheng Hu, Ying Wang, Debabrata Mukhopadhyay, Evette S. Radisky, Lizhi Zhang, Aurelia Lugea, Stephen J. Pandol, Yan Bi, Baoan Ji
Journal: Journal of Clinical Investigation (2019)

Currently, an effective targeted therapy for pancreatitis is lacking. Hereditary pancreatitis (HP) is a heritable, autosomal-dominant disorder with recurrent acute pancreatitis (AP) progressing to chronic pancreatitis (CP) and a markedly increased risk of pancreatic cancer. In 1996, mutations in PRSS1 were linked to the development of HP. Here, we developed a mouse model by inserting a full-length human PRSS1R122H gene, the most commonly mutated gene in human HP, into mice. Expression of PRSS1R122H protein in the pancreas markedly increased stress signaling pathways and exacerbated AP. After the attack of AP, all PRSS1R122H mice had disease progression to CP, with similar histologic features as those observed in human HP. By comparing PRSS1R122H mice with PRSS1WT mice, as well as enzymatically inactivated Dead-PRSS1R122H mice, we unraveled that increased trypsin activity is the mechanism for R122H mutation to sensitize mice to the development of pancreatitis. We further discovered that trypsin inhibition, in combination with anticoagulation therapy, synergistically prevented progression to CP in PRSS1R122H mice. These animal models help us better understand the complex nature of this disease and provide powerful tools for developing and testing novel therapeutics for human pancreatitis.
TCT-344 Impact of OCT-Guided PCI Using a Specific Stent Optimization Strategy on Clinical Outcomes in Comparison Between Patients With and Without Diabetes Mellitus
Authors: Masaru Kuroda, Masahito Kawata, Akira Matsuura, Kazumasa Adachi, Yasutaka Hirayama, Takeshi Matsuura, Tsubasa Noda, Mutsuki Kodaira, Masayuki Kintsu, Yuya Suzuki, Yuichiro Miyazaki, Tomoo Fujioka
Journal: Journal of the American College of Cardiology (2019)
Reversing activity of cancer associated fibroblast for staged glycolipid micelles against internal breast tumor cells
Authors: Yun Zhu, Fangying Yu, Yanan Tan, Yun Hong, Tingting Meng, Yupeng Liu, Suhuan Dai, Guoxi Qiu, Hong Yuan, Fuqiang Hu
Journal: Theranostics (2019)

Rationale: Nano-carrier based combinational therapies for tumor cells hold great potential to improve the outcomes of patients.However, cancer associated fibroblasts (CAFs) in desmoplastic tumors and the derived pathological tumor stroma severely impede the access and sensitibity of tumor cells to antitumor therapies.Methods: Glycolipid-based polymeric micelles (GLPM) were developed to encapsulate an angiotensin II receptor I inhibitor (telmisartan, Tel) and a cytotoxic drug (doxorubicin, DOX) respectively, which could exert combinational antitumor efficacy by reprogramming tumor microenvironment to expose the vulnerability of internal tumor cells.Results: As demonstrated, α-SMA positive CAFs significantly decreased after the pre-administration of GLPM/Tel in vitro, which accordingly inhibited the secretion of the CAFs derived stroma.The tumor vessels were further decompressed as a result of the alleviated solid stress inside the tumor masses, which promoted more intratumoral drug delivery and penetration.Ultimately, staged administration of the combined GLPM/Tel and GLPM/DOX at the screened molar ratio not only inhibited the stroma continuously, but also achieved a synergistic antitumor effect through the apoptosis-related peroxisome proliferator-activated receptor-gamma (PPAR-γ) pathway. Conclusion:In summary, the strategy of suppressing tumor stroma for subsequent combinational therapies against internal breast tumor cells could provide avenues for management of intractable desmoplastic tumors.
“Preoperative prediction of tumor recurrence in HCC - A commentary on: Dynamic liver function is an independent predictor of recurrence-free survival after curative liver resection for HCC - A retrospective cohort study” (Int J Surg 2019; Sep 5. pii: S1743-9191(19)30225–0. doi: 10.1016/j.ijsu.2019.08.033. [Epub ahead of print]
Authors: Daniel Heise, Ulf Peter Neumann
Journal: International Journal of Surgery (2019)
TCT-177 Long-Term Serial Functional Evaluation After Implantation of the Fantom Sirolimus-Eluting Bioresorbable Coronary Scaffold: The FANTOM II study
Authors: Yuichi Saito, Georgios Bouras, Alexandre Abizaid, Matthias Lutz, Didier Carrié, Joachim Weber-Albers, Jeffrey Anderson, Alexandra Lansky
Journal: Journal of the American College of Cardiology (2019)
TCT-514 LATIN Telemedicine Demonstrates Longitudinal Cost Savings From Avoiding Unnecessary Transfer of Patients
Authors: Sameer Mehta, Roberto Botelho, Jamil Cade, Marco Perin, Mauricio Prudente, Ricardo Cavalcanti, Cesar Dusilek, Rodolfo Cardoso, Nabil Hamdan, Luis Ignacio Calderon, Marco Alcocer-Gamba, Juan Carlos Perez Alva, Alfredo Estrada, Manuel De Los Rios Ibarra, Alejandro Ricalde, Alejandra Frauenfelder, Daniel Vieira, Gladys Pinto, Lorena Pisana, Francisco Nola, Seyna Krisciunas, Isabella Vallenilla, Maritza Luna, Jorge Cardenas, Akhil Vaid
Journal: Journal of the American College of Cardiology (2019)
TCT-509 Trends in the Management of ST-Segment Elevation Myocardial Infarction (STEMI): Insights From a Regional STEMI Program (2003 to 2018)
Authors: Santiago Garcia, Christian Schmidt, Ross Garberich, Emmanouil Brilakis, Anil Poulose, Michael Mooney, Ivan Chavez, M. Nicholas Burke, Yale Wang, Mario Goessl, Paul Sorajja, Jay Traverse, Scott Sharkey
Journal: Journal of the American College of Cardiology (2019)
Systematic KIT Sequencing Identifies Unsuspected Systemic Mastocytosis with Associated Hematological Neoplasm
Authors: Elizabeth A Morgan, Jeffrey W. Craig, Annette S. Kim, Geraldine S. Pinkus, Jon C. Aster, Frank C Kuo, David P. Steensma, R. Coleman Lindsley, Daniel J. DeAngelo
Journal: Blood (2017)
Cardiovascular Toxicities of Immune Checkpoint Inhibitors
Authors: Somedeb Ball, Raktim K. Ghosh, Sariya Wongsaengsak, Dhrubajyoti Bandyopadhyay, Gopal Chandra Ghosh, Wilbert S. Aronow, Gregg C. Fonarow, Daniel J. Lenihan, Deepak L. Bhatt
Journal: Journal of the American College of Cardiology (2019)
TCT-87 Levoatrial to Coronary Sinus Shunting as a Novel Strategy for Symptomatic Heart Failure: First-in-Human Experience
Authors: Trevor Simard, Marino Labinaz, Firas Zahr, Babak Nazer, William Gray, James Hermiller, Sunit-Preet Chaudhry, Leonardo Guimaraes, François Philippon, Peter Eckman, Josep Rodés-Cabau, Paul Sorajja, Benjamin Hibbert
Journal: Journal of the American College of Cardiology (2019)
TCT-492 Impact of Hemoglobin Concentration on Infarct Size in Patients With STEMI Undergoing PCI: Patient-Level Pooled Analysis From 2 Randomized Trials
Authors: Fotios Gkargkoulas, Shmuel Chen, Bahira Shahim, Ghazaleh Mehdipoor, Aaron Crowley, Ori Ben-Yehuda, Roxana Mehran, Akiko Maehara, Gregg Stone
Journal: Journal of the American College of Cardiology (2019)
TCT-639 Early Invasive Versus Initial Conservative Management Among Older Patients With Non-ST-Segment Elevation Acute Coronary Syndrome
Authors: Babikir Kheiri, Hossam Abubakar, Qais Radaideh, Oluwole Adegbala, Mohammed Osman, Ahmed Subahi, Emmanuel Akintoye, Mohammad Luay Alkotob
Journal: Journal of the American College of Cardiology (2019)
TCT-172 Hemodynamic Analysis of New Version Mirage Bioresorbable Scaffold and Metallic Ultimaster Stent: A New Era Begins With Shear Stress Analysis in Stent Assessment
Authors: Erhan Tenekecioglu, Ryo Torii, Yuki Katagiri, Robert-Jan Van Geuns, Kerem Pekkan, Christos Bourantas, Yoshinobu Onuma, Patrick Serruys
Journal: Journal of the American College of Cardiology (2019)
Studies on Starling's Law of the Heart
Authors: WILLIAM L. GLEASON, EUGENE BRAUNWALD
Journal: Circulation (1962)

The applicability of Starling's law of the heart to the circulation of intact human subjects was studied by means of serial biplane angiocardiography utilizing injections into the left ventricle in nine patients, four of whom were unanesthetized. The end-diastolic and end-systolic volumes of the left ventricle were determined from the angiocardiograms by the method described by Dodge, and stroke volumes were calculated by subtracting the end-systolic from the end-diastolic volumes. In four patients large beat-to-beat variations in left ventricular end-diastolic volume occurred. These were accompanied by changes in stroke volume which varied directly with the preceding left ventricular end-diastolic volume. In four patients the left ventricular end-diastolic volume remained about constant, and in these patients the stroke volume showed little or no change. From these observations it was concluded that the ventricular stroke volume is a function of the end-diastolic volume and that therefore Starling's law of the heart is applicable to man. In the ninth patient pulsus alternans occurred; this was accompanied by concordant alternation of the left ventricular end-diastolic volume; i.e., the larger end-diastolic volumes resulted in larger stroke volumes and higher systolic pressures than did the smaller end-diastolic volumes. These observations are compatible with the concept that alternation of ventricular contraction can be explained by alternation of end-diastolic volume.
TCT-662 Patients Who Do Not Receive Drug-Eluting Stent for In-Stent Restenosis: Characteristics and Outcomes
Authors: Moritz Blum, Bimmer Claessen, Roxana Mehran, Davide Cao, Melissa Aquino, Rishi Chandiramani, Ridhima Goel, Anastasios Roumeliotis, George Dangas, Usman Baber, Asaad Khan, Prakash Krishnan, Nitin Barman, Samin Sharma, Annapoorna Kini
Journal: Journal of the American College of Cardiology (2019)
TCT-284 Latest Update of the Worldwide Everyday Practice Registry Assessing the Xposition S Self-Apposing Stent in Challenging Lesions With Vessel Diameter Variance (SIZING Registry)
Authors: Steffen Schnupp, Marcus Siry, Adam Sukiennik, Daniel Weilenmann, Samer Somi, HoungBang Liew, Gillian A. Jessurun, Issameddine Ajmi, Alexander Ijsselmuiden, Floris Kauer, Vi-Phong Huynh
Journal: Journal of the American College of Cardiology (2019)
TCT-138 The Immediate Physiological Impact of Transcatheter Aortic Valve Replacement on Central Aortic Pressure in Patients With Severe Aortic Stenosis
Authors: Michael Michail, Andrea Comella, Liam McCormick, Robert Gooley, Kim Parker, Anthony Mathur, Alun Hughes, Adam Brown, James Cameron
Journal: Journal of the American College of Cardiology (2019)
Colorectal cancer cell-derived CCL20 recruits regulatory T cells to promote chemoresistance via FOXO1/CEBPB/NF-κB signaling
Authors: Dan Wang, Li Yang, Weina Yu, Qian Wu, Jingyao Lian, Feng Li, Shasha Liu, Aitian Li, Zhiang He, Jinbo Liu, Zhenqiang Sun, Weitang Yuan, Yi Zhang
Journal: Journal for ImmunoTherapy of Cancer (2019)

<h3>Background</h3> Colorectal cancer (CRC) is one of the most common forms of cancer worldwide. The tumor microenvironment plays a key role in promoting the occurrence of chemoresistance in solid cancers. Effective targets to overcome resistance are necessary to improve the survival and prognosis of CRC patients. This study aimed to evaluate the molecular mechanisms of the tumor microenvironment that might be involved in chemoresistance in patients with CRC. <h3>Methods</h3> We evaluated the effects of CCL20 on chemoresistance of CRC by recruitment of regulatory T cells (Tregs) in vitro and in vivo. <h3>Results</h3> We found that the level of CCL20 derived from tumor cells was significantly higher in Folfox-resistant patients than in Folfox-sensitive patients. The high level of CCL20 was closely associated with chemoresistance and poor survival in CRC patients. Among the drugs in Folfox chemotherapy, we confirmed that 5-FU increased the expression of CCL20 in CRC. Moreover, CCL20 derived from 5-FU-resistant CRC cells promoted recruitment of Tregs. Tregs further enhanced the chemoresistance of CRC cells to 5-FU. FOXO1/CEBPB/NF-κB signaling was activated in CRC cells after 5-FU treatment and was required for CCL20 upregulation mediated by 5-FU. Furthermore, CCL20 blockade suppressed tumor progression and restored 5-FU sensitivity in CRC. Lastly, the expression of these signaling molecules mediating chemoresistance was closely correlated with poor survival of CRC patients. <h3>Conclusions</h3> CRC cell-secreted CCL20 can recruit Tregs to promote chemoresistance via FOXO1/CEBPB/NF-κB signaling, indicating that the FOXO1/CEBPB/NF-κB/CCL20 axis might provide a promising target for CRC treatment.
Interstitial-resident memory CD8+ T cells sustain frontline epithelial memory in the lung
Authors: Shiki Takamura, Shigeki Kato, Chihiro Motozono, Takeshi Shimaoka, Satoshi Ueha, Kazuhiko Matsuo, Kosuke Miyauchi, Tomoko Masumoto, Asami Katsushima, Takashi Nakayama, Michio Tomura, Kouji Matsushima, Masato Kubo, Masaaki Miyazawa
Journal: The Journal of Experimental Medicine (2019)

Populations of CD8+ lung-resident memory T (TRM) cells persist in the interstitium and epithelium (airways) following recovery from respiratory virus infections. While it is clear that CD8+ TRM cells in the airways are dynamically maintained via the continuous recruitment of new cells, there is a vigorous debate about whether tissue-circulating effector memory T (TEM) cells are the source of these newly recruited cells. Here we definitively demonstrate that CD8+ TRM cells in the lung airways are not derived from TEM cells in the circulation, but are seeded continuously by TRM cells from the lung interstitium. This process is driven by CXCR6 that is expressed uniquely on TRM cells but not TEM cells. We further demonstrate that the lung interstitium CD8+ TRM cell population is also maintained independently of TEM cells via a homeostatic proliferation mechanism. Taken together, these data show that lung memory CD8+ TRM cells in the lung interstitium and airways are compartmentally separated from TEM cells and clarify the mechanisms underlying their maintenance.
TCT-799 A Pilot Study of Accelerated Radial Artery Hemostasis Following Percutaneous Transradial Coronary Angiography/Intervention, Utilizing a Novel Topical Hemostatic Agent in Conjunction With Surface Compression
Authors: Rajeev Anchan, Stephanie Besser, Linda Lee, John Blair, Rohan Kalathiya, Jonathan Paul, Sandeep Nathan
Journal: Journal of the American College of Cardiology (2019)
TCT-394 Differential Effects of Prolonged Dual Antiplatelet Therapy After Percutaneous Coronary Intervention in Patients Presenting With Versus Without Acute Myocardial Infarction
Authors: Kim Jihoon, Joo-Yong Hahn, Kyutae Park, Young Bin Song, Sangyoon Lee
Journal: Journal of the American College of Cardiology (2019)
TCT-276 Individual Patient Data Analysis of the BIOFLOW Study Program Comparing Safety and Efficacy of a Bioresorbable Polymer Sirolimus-Eluting Stent to a Durable Polymer Everolimus-Eluting Stent
Authors: Gert Richardt, Thierry Lefevre, Shigeru Saito, David Kandzari, J.J. Koolen, Ralph Toelg
Journal: Journal of the American College of Cardiology (2019)
TCT-32 Clinical Outcomes of Imaging- and Physiology-Guided PCI Without Contrast Administration in Advanced Renal Failure
Authors: Hussein Rahim, Erin Flattery, Fotios Gkargkoulas, Shmuel Chen, Aaron Crowley, Ajay Jayant Kirtane, Dimitri Karmpaliotis, Jeffrey W. Moses, Gary Mintz, Akiko Maehara, Ori Ben-Yehuda, Gregg Stone, Russell Crew, Geoffrey Dube, Mark Hardy, Sumit Mohan, Jai Radhakrishnan, Lloyd Ratner, David Cohen, Martin Leon, Ziad Ali
Journal: Journal of the American College of Cardiology (2019)