AB0788C PSORIASTIC ARTHRITIS IN PATIENTS DIAGNOSED WITH PSORIASIS ASSISTING DERMATOLOGY CONSULTATION IN A COHORT OF THE DOMINICAN REPUBLIC
Authors: Anllely altagracia Tapia Báez, Franchesca alvarez Polanco, Esthela Loyo de López, Carmen Tineo, Glenny Paulino, Catherine Rodríguez, Diana Rozón Rozón, Yanela Suriel Ayala, Yamel Camilo Uribe, Piery Guzmán, Idelfi Sánchez
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background:</h3> Psoriatic arthritis (PsA) is a disease of an inflammatory, heterogeneous nature that involves skin, nails, peripheral and axial joints, as well as the entheses. Due to its systemic involvement, it makes diagnosis and therapy a challenge in clinical practice. (1) It has been estimated that around 6% to 41% of patients with Psoriasis (Pso) will develop PsA, finding an accumulated incidence of 1.7% at 5 years of diagnosis of Psoriasis, 3.1% at 10 years and 5.1% at 20 years (2). In the Dominican Republic we do not have studies that characterize this pathology, so it would be interesting to be able to specify the clinical course, as well as the risk factors and associated prognoses for the development of this entity. <h3>Objectives:</h3> To determine the factors associated with psoriatic arthritis in patients diagnosed with psoriasis attending the Dermatology service. <h3>Methods:</h3> A multicenter, descriptive study of primary and secondary source data collection was conducted at the Psoriasis clinic of the Regional University Hospital José María Cabral and Báez, Cibao Regional Dermatological institute and the Foundation to support patients with psoriasis and psoriatic arthritis (FUNAPAPSO), in the period of august-December 2018, the universe consisted of 304 patients, 103 patients met inclusion criteria. After signing informed consent, a form was completed that included general, clinical, serological and image data. Analysis of the variables was performed and Chi 2 was used, considering statistical significance p &lt;0.05. <h3>Results:</h3> Of a total of 103 patients with psoriasis, the mean age was 40 ± 13 years, 63.1% male, 36.9% female. The prevalence of psoriatic arthritis by CASPAR criteria was 36.89%. The presentation of arthritis was asymmetric oligoarthritis in 56.52%, symmetric polyarthritis 21.74% and distal interphalangeal arthritis 13.04%, radiographic findings were present in 7.77% (p: 0.00) of patients with PsA. The forms of presentation of Pso that were most associated with arthritis were plaques 48.57% (p: 0.000) and drop 12.5% (p: 0.01). The quality of life was average in 39.47% and poor in 18.42%. Psoriasic onychopathy was present in 40.23% (p: 0.048) of patients with arthritis. 39% of patients had some type of comorbidity, and of these arterial hypertension obtained 34% (n = 13), obesity 26% (n = 10) and diabetes mellitus 21% (n = 8). <h3>Conclusion:</h3> The presence of psoriatic arthritis in the population with psoriasis in our environment is high. This is related to the presence of psoriatic onicopathy, radiographic findings and deterioration in the quality of life of patients. <h3>References</h3> [1] S Raychaudhuri, RW, aS, SR, EM. Management of psoriatic arthritis: Early diagnosis, monitoring of disease severity and cutting edge therapies. Journal of autoimmunity. 2016Octubre. [2] a Ogdie P. The Epidemiology of Psoriatic arthritis. Rheum Dis Clin N am.2015 [3] P Helliwel. Natural history, prognosis and socioeconomic aspects of Psoriatic arthrits. Rheum Dis Clin N am. 2015 [4] M. Boutet, aGC. Role of the IL-23/IL-17 axis in Psoriasis and Psoriatic arthritis: the clinic importance of its divergence in skin and joints. Int J Molc Sci 2018; 19(2):p.530 [5] L. Sakkas. Are psoriasis and psoriatic arthritis the same disease? autoimmunity Review.2017Enero; 16(1): p10-15 [6] J Torre. Utilidad y aplicación en la práctica clínica de los criterios CASPAR. Reumatol Clin2010; 6(1):p 18-21 [7] L Gossec, LM, aS, PC, DJ. Management of psoriatic arthritis in 2016: a comparison of EULAR and GRAPPA recommendations. Nature Reviews Rheumatology. 2016 <h3>Disclosure of interests:</h3> None declared