tbuckley/cabot-search huggingface dataset:
Abstract #3717: Identification of a dual JAK-2/BCR-ABL kinase inhibitor for treatment of myeloproliferative disorders
Authors: Shashidhar Jatiani, Stephen Cosenza, Venkat Pallela, Ji Hee Ha, Stacey Baker, M V Reddy, E. Reddy
Journal: Cancer Research (2009)

Myeloproliferative disorders (MPD) are clonal malignancies characterized by overproduction of one or more hematopoietic lineages with relatively normal differentiation. The molecular pathogenesis of several MPDs has been well characterized, and is frequently attributable to mutations that result in constitutive activation of a protein tyrosine kinase. The classic MPDs are subdivided into chronic myeloid leukemia (CML i.e. BCR-ABL+) and the BCR-ABL- classic MPDs, i.e. polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF). Imatinib, which is an inhibitor of the BCR-ABL tyrosine kinase, has been a remarkable success for the treatment of CML. However, a significant proportion of patients chronically treated with imatinib develop resistance due to acquisition of mutations in the kinase domain of BCR-ABL. A novel gain-of-function mutation in the JAK2 tyrosine kinase (JAK2V617F) has been observed in about 95% of patients with PV and 50% of those with either ET or PMF. This mutation has also been found in patients with non-classic MPDs such as refractory anemia with ringed sideroblasts associated with thrombocytosis (RARS-T), chronic neutrophilic leukemia (CNL), atypical CML and chronic myelomonocytic leukemia (CMML) at incidences of 50%, 20%, 20% and 3%, respectively. JAK2V617F has been found to confer erythropoietin-independent growth of the mutant cells in vitro due to deregulation of signaling pathways downstream of JAK2. These findings have opened new avenues for the diagnosis and classification of patients with these disorders, and identify a new molecular target for drug discovery. In our quest to develop targeted therapies for MPD, we screened a compound library of molecules and identified an \#945;-stryl benzyl sulfone, ON044580 that exhibits potent JAK2 inhibitory activity. ON 044580 is a substrate-competitive inhibitor of JAK2 and is unaffected by physiological levels of ATP. ON044580 interferes with IL-3 mediated proliferation pathways that signal via JAK2 to inhibit the growth and survival of Ba/F3-JAK2V617F cells. Growth of two patient cell lines, HEL and SET-2, which express the activating JAK2V617F mutation is also inhibited by ON044580. ON 044580 is also a potent inhibitor of the tyrosine kinase activity of BCR-ABL purified from mammalian cells. Further, ON 044580 inhibits the phosophorylation of BCR-ABL and Stat5 in cultured CML cells. Finally, not only does ON044580 induce apoptosis in cells expressing imanitib-sensitive and imanitib-resistant forms of BCR-ABL, it does so in primary cells from CML patients. Taken together, our results suggest that ON 044580 is a dual JAK2/BCR-ABL kinase inhibitor with therapeutic potential to treat JAK2V617F positive MPDs and CML.  Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 3717.
Glomerular C4d deposition can precede the development of focal segmental glomerulosclerosis
Authors: Nina A. van de Lest, Malu Zandbergen, Ron Wolterbeek, Reinhold Kreutz, Leendert A. Trouw, Eiske M. Dorresteijn, Jan A. Bruijn, Ingeborg M. Bajema, Marion Scharpfenecker, Jamie S. Chua
Journal: Kidney International (2019)
TRANSORAL OUTLET REDUCTION WITH SEMI-CIRCUMFERENTIAL ENDOSCOPIC SUBMUCOSA DISSECTION IS SUPERIOR TO ARGON PLASMA COAGULATION
Authors: M Hollenbach, L Selig, S Lellwitz, S Beer, J Feisthammel, J Rosendahl, T Schaumburg, J Mössner, A Hoffmeister
Journal: Endoscopy (2019)

Roux-en-Y gastric bypass (RYGB) is a standard bariatric and metabolic procedure to induce weight-loss. Years after the intervention, a dilated gastrojejunal anastomosis (GJA) leads to weight regain or dumping syndrome. Recently, transoral outlet reduction (TOR) to GJA-diminution has been established by endoscopic suturing after tissue ablation with argon plasma coagulation (APC). However, rupture of sutures before scarring can lead to recurrent dilation of GJA. In this study, we compared a semi-circulated endoscopic submucosa dissection (ESD) as a novel approach for its superiority over APC before TOR.
Magnetic Resonance Imaging Is More Sensitive Than PET for Detecting Treatment-Induced Cell Death–Dependent Changes in Glycolysis
Authors: Richard L. Hesketh, Jiazheng Wang, Alan J. Wright, David Y. Lewis, Alice E. Denton, Richard Grenfell, Jodi L. Miller, Robert Bielik, Marcel Gehrung, Maria Fala, Susana Ros, Bangwen Xie, De-en Hu, Kevin M. Brindle
Journal: Cancer Research (2019)

Abstract Metabolic imaging has been widely used to measure the early responses of tumors to treatment. Here, we assess the abilities of PET measurement of [18F]FDG uptake and MRI measurement of hyperpolarized [1-13C]pyruvate metabolism to detect early changes in glycolysis following treatment-induced cell death in human colorectal (Colo205) and breast adenocarcinoma (MDA-MB-231) xenografts in mice. A TRAIL agonist that binds to human but not mouse cells induced tumor-selective cell death. Tumor glycolysis was assessed by injecting [1,6-13C2]glucose and measuring 13C-labeled metabolites in tumor extracts. Injection of hyperpolarized [1-13C]pyruvate induced rapid reduction in lactate labeling. This decrease, which correlated with an increase in histologic markers of cell death and preceded decrease in tumor volume, reflected reduced flux from glucose to lactate and decreased lactate concentration. However, [18F]FDG uptake and phosphorylation were maintained following treatment, which has been attributed previously to increased [18F]FDG uptake by infiltrating immune cells. Quantification of [18F]FDG uptake in flow-sorted tumor and immune cells from disaggregated tumors identified CD11b+/CD45+ macrophages as the most [18F]FDG-avid cell type present, yet they represented &amp;lt;5% of the cells present in the tumors and could not explain the failure of [18F]FDG-PET to detect treatment response. MRI measurement of hyperpolarized [1-13C]pyruvate metabolism is therefore a more sensitive marker of the early decreases in glycolytic flux that occur following cell death than PET measurements of [18F]FDG uptake. Significance: These findings demonstrate superior sensitivity of MRI measurement of hyperpolarized [1-13C]pyruvate metabolism versus PET measurement of 18F-FDG uptake for detecting early changes in glycolysis following treatment-induced tumor cell death.
2-Methoxyestradiol-3,17-O,O-bis-sulfamate binds to the colchicine site of tubulin and down-regulates survivin, inhibits the anti-apoptotic protein Bcl-2 and down-regulates the pro-angiogenic transcription factor HIF-1 alpha
Authors: J M Day, S P Newman, Y T Ho, B Raobaikady, S Tagg, M P Leese, P G Kasprzyk, Potter Bvl., M J Reed, A Purohit
Journal: Cancer Research (2006)
Molecular sub types of breast cancer in a developing country. Classification immunohistochemical: Clinicopathologic feature and survival analysis
Authors: H.R. Castro, L. Salazar, L. Garcia, N. Castro Sanchez, P. Ramos, K. Cruz
Journal: Annals of Oncology (2019)

Background: Breast cancer (BC) is a heterogeneous malignancy and it's possible to identify by inmmunohistochemistry, four subtypes with different clinical and biological behavior. Our aim was to evaluate the prevalence, disease free survival (DFS) and overall survival (OS) influence of these subtypes on the Guatemalam population. Methods: Data of 954 patients Instituto Guatemalteco de Seguridad Social treated from 2008-2014. BC subtypes were categorized in Luminal A (RE+ and/or RP+, HER2-), Luminal B (RE+ and/or RP+, HER2+ o Ki-67> 14%); HER2 (RE-, RP-, HER2+) and triple negative tumors (TNT) (RE-, RP-, HER2-). Results: Median age was 52 years (23-95), 55% were premenopausal. We found that 522 (56%) of the cases were luminal A, 190 (20%) were triple negative tumors (TNT), luminal B were 73 (8%) and HER2-positive in 152 (20%) of cases. Nine patients (3%) had other breast cancer contralateral. In 438 (70%) of all the cases were found in locally advanced stages (IIB–IIIC); 773 (81%) patients underwent radical mastectomy and 181 (19%) undergoing conservative surgery. We have found in the univariate analysis the following statistically significant variables for DFS: clinical stage (I – IIa vs IIb – IIIC; 88% vs 70%; p = 0.001), nuclear grade (grade 1, 2 vs 3; 83% vs 62%; p = 0.001) and pathologic response to neoadjuvant chemotherapy (total vs other response; 76% vs 54%; p = 0.001), and status Her-2 subtype was borderline (positive vs negative; p = 0.079). Clinical stage (p = 0.05), histologic grade (P = 0.45), response to neoadjuvant (p = 0.01) as significant factors of prognosis for the OS. The OS by molecular subtype were Luminal A (94%), Luminal B (75%), HER2 (79%) and TNT (68%), (p = 0.001). Conclusions: The prevalence of molecular subtypes of BC is similar to reported internationally. In Guatemala the majority of patients with BC are diagnosed in advanced stage. Legal entity responsible for the study: Hugo Castro. Funding: Has not received any funding. Disclosure: All authors have declared no conflicts of interest.
Recurrent oral ulceration: Etiology, classification, management, and diagnostic algorithm
Authors: Elizabeth A. Bilodeau, Rajesh V. Lalla
Journal: Periodontology 2000 (2019)

Abstract Recurrent oral ulcerations are manifestations of a heterogeneous set of both general and more‐or‐less specific oral diseases due to numerous potential etiologies, including, but not limited to, infections, medications, autoimmune disease, and other systemic disease. This review discusses the pathogenesis, clinical presentation, diagnosis, and management of the common causes of recurrent oral ulceration. The following types/etiologies of recurrent oral ulceration are covered: traumatic ulceration, chemical ulceration, recurrent aphthous stomatitis, medication‐related ulceration, infectious ulceration, mucocutaneous disease, and autoimmune/systemic disease. A diagnostic algorithm for recurrent oral ulceration is also presented.
Intein-mediated protein trans-splicing expands adeno-associated virus transfer capacity in the retina
Authors: Patrizia Tornabene, Ivana Trapani, Renato Minopoli, Miriam Centrulo, Mariangela Lupo, Sonia de Simone, Paola Tiberi, Fabio Dell’Aquila, Elena Marrocco, Carolina Iodice, Antonella Iuliano, Carlo Gesualdo, Settimio Rossi, Laura Giaquinto, Silvia Albert, Carel B. Hoyng, Elena Polishchuk, Frans P. M. Cremers, Enrico M. Surace, Francesca Simonelli, Maria A. De Matteis, Roman Polishchuk, Alberto Auricchio
Journal: Science Translational Medicine (2019)

Adeno-associated viral vectors reconstitute large proteins in the retina via intein-mediated protein trans-splicing.
EUS-GUIDED DRAINAGE OF PERIPANCREATIC FLUID COLLECTIONS USING FULLY COVERED METAL AND PLASTIC STENTS
Authors: S Jo, SS Lee, D Oh, TJ Song, DH Park, DW Seo, SK Lee, MH Kim
Journal: Endoscopy (2019)

Endoscopic ultrasound (EUS)-guided drainage of peripancreatic fluid collections (PFCs) by using double-pigtail plastic stents (DPPSs) requires placement of multiple stents for favorable outcomes. EUS- guided drainage PFC with fully covered metal stents (FCSEMSs) has become increasingly used. We aim to evaluate the technical, clinical outcomes, and adverse events of EUS-guided drainage of PFC with DPPSs and FCSEMSs.
LEOPARD STUDY: ITALIAN MULTICENTER PROSPECTIVE STUDY OF PANCREATIC CYSTIC LESIONS WITH CONFOCAL ENDOMICROSCOPY: FEASIBILITY AND SAFETY EVALUATION
Authors: H Bertani, R Pezzilli, F Pigò, M Bruno, C De Angelis, G Manfredi, G Delconte, R Conigliaro, E Buscarini
Journal: Endoscopy (2019)

Despite significant improvements in imaging technology, the diagnosis and management of pancreatic cystic lesions remains a significant clinical challenge. Needle-based confocal laser endomicroscopy (nCLE) is a unique imaging technique, enabling microscopic observation of solid organs and cystic tumors, in vivo and in real-time, during an EUS-FNA procedure.
Abstract 18705: Regional Variability of Microcirculatory Resistance After Successful Percutaneous Coronary Intervention
Authors: Toshiyuki Iwai, Ryo Masuda, Takamitsu Takagi, Tadashi Murai, Tetsumin Lee, Tsunekazu Kakuta
Journal: Circulation (2012)

Background: The main drawback of Fractional Flow Reserve (FFR) measurements occurs in the presence of microvascular disease, as FFR does not take into consideration the contribution of abnormal microvascular resistance. Normal FFR with concomitant microcirculatory disease may be a cause of angina symptoms or myocardial ischemia. Recently, the blood flow in the myocardium has been reported to show significant spatial heterogeneity. We assessed the hypothesis that heterogeneity of regional microvascular resistance exists in patients after successful percutaneous coronary intervention (PCI). Methods and Results: FFR and the index of microcirculatory resistance (IMR) were measured after successful PCI in 20 patients with native de novo discrete coronary lesions both in the territory of the culprit vessel and in the reference territory of non-culprit vessel. Hyperemic mean transmit time (Tmn) was used for the assessment of coronary flow. FFR value after PCI was 0.89 (IQR 0.82-0.96). IMR value in the culprit vessel was 18.8 (IQR 12.1-25.7), and 19.05 (IQR 14.3-26.7) in the non-culprit vessel, respectively. There was no significant relationship between these two regional measurements (r 2 =0.0128, p=ns). Mean difference between these two measures was 17.4 ± 15.9. The coefficients of variation of IMR were 75.7% in the culprit vessel, and 59.5% in the non-culprit vessel. There was a significant relationship between IMR and Tmn both in the culprit vessels (r=0.968, p&lt;0.0001) and non-culprit vessels (r=0.913, p&lt;0.0001). Conclusion: A considerable regional heterogeneity of coronary perfusion and microvascular resistance were observed in the present study. There is a high inter-subject, intra-subject, and interregional variability of coronary flow and microvascular resistance in patients after successful PCI. These results highlight the difficulty in establishing the limits of normal microvascular resistance or vasodilating response in patients with ischemic heart disease.
BARIATRIC ENDOSCOPY: COMPARISON OF 962 PATIENTS OF 4 DIFFERENT TECHNIQUES WITH SAME ENDOSCOPIST AND SAME FOLLOW UP TEAM
Authors: G Lopez-Nava, I Bautista-Castaño
Journal: Endoscopy (2019)

New bariatric endoscopic techniques (BET) have been developed for the obesity treatment. Most centers tend to specialize in one procedure, such as Endoscopic sleeve gastroplasty (APOLLO gastroplasty), Primary Obesity Surgery Endolumenal (POSE method) or Intragastric Balloon (IGB) (Orbera or Dual), so it is difficult to compare different techniques results. The objective of this study is to evaluate different BET performed by the same endoscopist and same follow up team.
RISK OF SMALL BOWEL BLEEDING ASSOCIATED WITH USE OF ORAL ANTICOAGULANTS OR ANTIPLATELET AGENTS: A RETROSPECTIVE COHORT STUDY
Authors: A Mussetto, AT Garribba, S Gasperoni, O Triossi
Journal: Endoscopy (2019)

Antiplatelet and anticoagulant therapy is increasingly being used for cardiovascular prevention. Novel direct-acting oral anticoagulants (NOAC) represent a recent, alternative, family of drugs. Rate of bleeding complications by NOAC seems to be comparable to those of warfarin but a previously assumed increase in gastrointestinal bleeding complications was meanwhile confirmed. The risk of bleeding in the setting of suspected small bowel bleeding (SSBB) in patients taking antiplatelets or anticoagulants has been poorly investigated.
Exploration endoscopique haute du reflux gastro-oesophagien chez les patients obèses
Authors: Y Dannouni, H Sghir, I Elhidaoui, K Benjouad, S Oubaha, Z Samlani, K Krati
Journal: Endoscopy (2019)

Considérée par l'organisation mondiale de la santé comme la première maladie non infectieuse dans le monde, l'obésité engendre une série de symptômes chroniques. Le reflux gastro-oesophagien (RGO) est un motif de consultation fréquent chez les patients obèses avec une corrélation entre intensité des symptômes et indice de masse corporelle (IMC). Le but de ce travail est de déterminer la fréquence et la sévérité des symptômes de RGO chez les patients obèses ainsi que de faire un bilan lésionnel endoscopique.
COPD: inhalers distract from exercise and clean air
Authors: Nicholas Sharvill
Journal: BMJ (2019)

Salisbury says that Boehringer Ingelheim is paying £748 000 (€868 000; $973 000) towards an integrated multidisciplinary respiratory team in Oxford, compared with £181 000 from the clinical commissioning group (CCG).1 I hope the CCG finance and …
Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression
Authors: Robert M. Hughes, Brian W. Simons, Hamda Khan, Rebecca Miller, Valentina Kugler, Samantha Torquato, Debebe Theodros, Michael C. Haffner, Tamara Lotan, Jessie Huang, Elai Davicioni, Steven S. An, Ryan C. Riddle, Daniel L.J. Thorek, Isla P. Garraway, Elana J. Fertig, John T. Isaacs, W. Nathaniel Brennen, Ben H. Park, Paula J. Hurley
Journal: Cancer Research (2019)

Tumor progression to metastasis is not cancer cell autonomous, but rather involves the interplay of multiple cell types within the tumor microenvironment. Here we identify asporin (ASPN) as a novel, secreted mesenchymal stromal cell (MSC) factor in the tumor microenvironment that regulates metastatic development. MSCs expressed high levels of ASPN, which decreased following lineage differentiation. ASPN loss impaired MSC self-renewal and promoted terminal cell differentiation. Mechanistically, secreted ASPN bound to BMP-4 and restricted BMP-4-induced MSC differentiation prior to lineage commitment. ASPN expression was distinctly conserved between MSC and cancer-associated fibroblasts (CAF). ASPN expression in the tumor microenvironment broadly impacted multiple cell types. Prostate tumor allografts in ASPN-null mice had a reduced number of tumor-associated MSCs, fewer cancer stem cells, decreased tumor vasculature, and an increased percentage of infiltrating CD8
Abstract 20067: Impact of Statins on Long-Term Cardiovascular Outcomes in Patients Undergoing Coronary Artery Calcium Scoring: Results From the Walter Reed Registry
Authors: Joshua D Mitchell, Nicole Fergestrom, Patrick Moon, Robert Paisley, Todd C Villines
Journal: Circulation (2016)

Introduction: Coronary artery calcium (CAC) scoring significantly improves cardiovascular risk prediction as compared to standard cardiovascular risk factors. However, the impact of statins on athe...
CD8+ T cells induce cachexia during chronic viral infection
Authors: Hatoon Baazim, Martina Schweiger, Michael Moschinger, Haifeng Xu, Thomas Scherer, Alexandra Popa, Suchira Gallage, Adnan Ali, Kseniya Khamina, Lindsay Kosack, Bojan Vilagos, Mark Smyth, Alexander Lercher, Joachim Friske, Doron Merkler, Alan Aderem, Thomas H. Helbich, Mathias Heikenwälder, Philipp A. Lang, Rudolf Zechner, Andreas Bergthaler
Journal: Nature Immunology (2019)
FEASIBILITY OF A NEW ELECTROSURGICAL UNIT “AUTOCONIII400” FOR ENDOSCOPIC SUBMUCOSAL DISSECTION
Authors: K Yamamoto, Y Takagi, M Mori, Y Sato, Y Tokuda, N Tatsumi, T Michida, T Ito
Journal: Endoscopy (2019)

Endoscopic submucosal dissection (ESD) is very useful for treating large superficial gastrointestinal tumors in en bloc resection manner, but it requires high skill. Especially beginners tend to cut the tissue slowly in ESD, and so it make the tissue burnt. Therefore, the ability of the electrosurgical unit and its setting are extremely important for ESD. VIO series (ERBE, Germany) is often employed for ESD, but usefulness of other electrosurgical units for ESD is not fully elucidated. Herein, we investigated the feasibility of the a new electrosurgical unit “AUTOCONIII400” (KARL STORTZ, Germany) for endoscopic submucosal dissection.
SECOND FRONTAL VIEW VERSUS PROXIMAL RETROFLEXION IN RIGTH COLON IN COLO-RECTAL CANCER SCREENING: MULTICENTRE RANDOMIZED TRIAL
Authors: MH Núñez-Rodriguez, P Diez-Redondo, F Riu, M Cimavilla, A Loza, L Hernandez Villalba, M Pérez-Miranda
Journal: Endoscopy (2019)

Colonoscopy, the gold standard for the detection of colorectal cancer, fails to detect 22 – 28% of polyps, resulting in interval cancer (IC). IC are more frequent in right colon. The aim of this study was to compare second view of right colon with proximal retroflexion to second forward viewing in the detection of colorectal neoplasm in colorectal cancer screening programme. (NCT03041532).
SAME SESSION BI-DIRECTIONAL ENDOSCOPY – TIME FOR A TAILORED APPROACH
Authors: M Alfa-Wali, CK Khoo, A Varma, M Saedon
Journal: Endoscopy (2019)

In the United Kingdom (UK), patients with iron deficiency anaemia (IDA) are referred to secondary care for investigations. The British Society of Gastroenterology (BSG) recommends urgent upper gastrointestinal (UGI) and lower gastrointestinal (LGI) endoscopies for patients with IDA. This is the commonest indication for simultaneous bi-directional endoscopy. The aim of this study was to determine the utility of bi-directional endoscopy in patients with IDA.
Aggressive T‐cell lymphomas: 2019 updates on diagnosis, risk stratification, and management
Authors: Jasmine M. Zain
Journal: American Journal of Hematology (2019)

Abstract Introduction Aggressive T‐cell lymphomas continue to have a poor prognosis. There are over 27 different subtypes of peripheral T‐cell lymphoma (PTCL) and we are now beginning to understand the differences between the various subtypes beyond histologic variations. Molecular pathogenesis of various subtypes of PTCL Gene expression profiling can help in diagnosis and prognostication of various subtypes including PTCL‐nos and anaplastic large cell lymphoma. In addition, mutational analysis is now being incorporated in clinical trials of novel agents to evaluate various biomarkers of response to allow better therapeutic choices for patients. Targeted therapies There are many targeted agents currently in various stages of clinical trials for PTCL that take advantage of the differential expression of specific proteins or receptors in PTCL tumors. The most promising is the CD30 directed antibody drug conjugate brentuximab vedotin. This has recently been approved by the Food and Drug Administration for the upfront treatment of CD30 expressing PTCLs in combination with cyclophosphamide, doxorubicin, and prednisone chemotherapy. Other notable targets are CD25, CCR4 tag, PI3kinase inhibitors, and JAK/STAT inhibitors. Anaplastic lymphoma kinase (ALK) inhibitors are promising for ALK expressing tumors. Immunotherapies The use of checkpoint inhibitors in the treatment of PTCL is still controversial. The most promising results have been seen in cases of extranodal natural killer cell/T‐cell lymphomas and cutaneous T‐cell lymphomas. For all other subtypes, immune checkpoint inhibitors should be used with extreme caution and only in the context of a clinical trial. Allogeneic stem cell transplant continues to be the curative therapy for most aggressive subtypes of PTCL.
Erratum. Fetal Macrosomia and Neonatal Hyperinsulinemic Hypoglycemia Associated With Transplacental Transfer of Sulfonylurea in a Mother With <i>KCNJ11</i>-Related Neonatal Diabetes. Diabetes Care 2014;37:3333–3335
Authors: Nele Myngheer, Karel Allegaert, Andrew Hattersley, Tim McDonald, Holger Kramer, Frances M. Ashcroft, Johan Verhaeghe, Chantal Mathieu, Kristina Casteels
Journal: Diabetes Care (2019)

On page 3335 of the article cited above, funding information was added for author Frances M. Ashcroft. …
OUTCOMES OF ENDOSCOPIC SUBMUCOSAL DISSECTION (ESD) AT THE ANO-RECTAL JUNCTION AND ILEOCECAL VALVE
Authors: F Iacopini, C Grossi, Y Saito, W Elisei, T Gotoda, G Costamagna
Journal: Endoscopy (2019)

Endoscopic resection difficulty of superficial neoplasms at the perineal rectum is related to the narrowness of the anal canal and high intraoperative bleeding. Resection at the ileocecal valve (ICV) is difficult due to the variable anatomy and the possible neoplasm extension into the terminal ileum. Aim was to assess ESD outcomes of neoplasms at the perineal rectum and ICV.