tbuckley/cabot-search huggingface dataset:
SAT0119 Denial is a coping strategy in early rheumatoid arthritis
Authors: GJ Treharne, AC Lyons, S Mason, GD Kitas
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> Rheumatoid Arthritis (RA) is associated with negative psychological outcomes, including depression. Denial is a coping strategy in stressful situations, with well-documented impact on psychological and physical outcome, but has been little studied in RA. <h3>Objectives</h3> To investigate several psychological, social, demographic, and physical factors as predictors of the use denial as a coping strategy in RA. <h3>Methods</h3> Patients:118 hospital outpatients with early RA (4 years; N = 84). Denial: Reaction to Impairment and Disability Inventory (RIDI). Other assessments: Age, Sex, VAS for Pain and Fatigue, Arthritis Self-Efficacy Scale (ASES), Patient Knowledge Questionnaire (PKQ), Social Support Survey (SSS), Health Assessment Questionnaire (HAQ). Statistics: Principal component analysis (to examine factor structure of Denial questions); hierarchical multiple regression (to determine predictors of Denial). <h3>Results</h3> Three denial factors with eigenvalues &gt;1 were extracted: "Future Denial" (3 items; 33% of variance), "Conditional Improvement" (3 items; 22% of variance), and "Present Denial" (1 item; 16% of variance). The Future Denial subscale had good internal consistency (alpha = 0.83 compared to alpha = 0.47 for Conditional Improvement). Early RA and being single were the only significant predictors of Future Denial. Better functional ability was the only predictor of Present Denial. No factors predicted the use of Conditional Improvement. <h3>Conclusion</h3> Aspects of denial, particularly Future Denial, may be utilised in the early stages of RA, mainly by those without a partner to rely upon, as a coping strategy to "buy time" in order to come to terms with actual and potential disease impact. Patients who report better functional ability may also be denying current loss of ability; this raises questions about the beneficial nature of self-deceptive attitudes in RA patients and may be clarified by a longitudinal study. Denial should be taken into account when assessing both physical and psychosocial outcomes in RA. <h3>Reference</h3> Antonak RF, Livneh H. A hierarchy of reactions to disability. Int J Rehabil Res. 1991;14:13–24
Canadian court says wife cannot block husband’s medically assisted death
Authors: Owen Dyer
Journal: BMJ (2020)

A Nova Scotia man is free to seek a medically assisted death in the next few days after the province’s Court of Appeal refused to extend a temporary injunction granted to his wife, who claimed that he was exaggerating his illness and did not qualify.1

The case, which has led the anonymous couple to separate after a marriage of nearly 50 years, comes as Canada’s assisted dying law is in a state of flux. The country’s Supreme Court has declared the current law overly restrictive in that it requires two doctors to certify that the patient faces a “reasonably foreseeable” death from a condition, as well as unbearable suffering. The government has promised to legislate to remove the foreseeable death requirement, but it has …
PTEN Alterations Are Related to Unfavorable Prognosis in Children with T-Cell Acute Lymphoblastic Leukemia Treated According to ALL IC-BFM Protocols
Authors: Bronisława Szarzyńska-Zawadzka, Joachim B. Kunz, Maria Kosmalska, Katarzyna Zdon, Przemysław Biecek, Obul Reddy Bandapalli, Sędek Łukasz, Jerzy R. Kowalczyk, Tomasz Szczepański, Andreas E. Kulozik, Michał Witt, Malgorzata Dawidowska
Journal: Blood (2017)
UK trade deal with US must not lead to drug price rises, say doctors
Authors: Elisabeth Mahase
Journal: BMJ (2020)

The BMA must work to ensure that any future trade deal between the UK and the US does not lead to a rise in the price of medicines or weaken the UK’s ability to negotiate prices with US companies, doctors have said.

Delegates at the BMA annual representative meeting on 15 September voted for the motion, which also called for the BMA to lobby the relevant organisations to ensure that any such trade deal “does not adversely affect the safety …
Non-linear fitting with joint spatial regularization in arterial spin labeling
Authors: Oliver Maier, Stefan M. Spann, Daniela Pinter, Thomas Gattringer, Nicole Hinteregger, Gerhard G. Thallinger, Christian Enzinger, Josef Pfeuffer, Kristian Bredies, Rudolf Stollberger
Journal: Medical Image Analysis (2021)

Multi-Delay single-shot arterial spin labeling (ASL) imaging provides accurate cerebral blood flow (CBF) and, in addition, arterial transit time (ATT) maps but the inherent low SNR can be challenging. Especially standard fitting using non-linear least squares often fails in regions with poor SNR, resulting in noisy estimates of the quantitative maps. State-of-the-art fitting techniques improve the SNR by incorporating prior knowledge in the estimation process which typically leads to spatial blurring. To this end, we propose a new estimation method with a joint spatial total generalized variation regularization on CBF and ATT. This joint regularization approach utilizes shared spatial features across maps to enhance sharpness and simultaneously improves noise suppression in the final estimates. The proposed method is evaluated at three levels, first on synthetic phantom data including pathologies, followed by in vivo acquisitions of healthy volunteers, and finally on patient data following an ischemic stroke. The quantitative estimates are compared to two reference methods, non-linear least squares fitting and a state-of-the-art ASL quantification algorithm based on Bayesian inference. The proposed joint regularization approach outperforms the reference implementations, substantially increasing the SNR in CBF and ATT while maintaining sharpness and quantitative accuracy in the estimates.
Out-of-Pocket Costs for Novel Guideline-Directed Diabetes Therapies Under Medicare Part D
Authors: Colette DeJong, Camlyn Masuda, Randi Chen, Dhruv S. Kazi, R. Adams Dudley, Chien-Wen Tseng
Journal: JAMA Internal Medicine (2020)

This study examines cost sharing for novel second-line diabetes treatment agents under Medicare Part D.
Assessing a novel, lab-free, point-of-care test for SARS-CoV-2 (CovidNudge): a diagnostic accuracy study
Authors: Malick M Gibani, Christofer Toumazou, Mohammadreza Sohbati, Rashmita Sahoo, Maria Karvela, Tsz-Kin Hon, Sara De Mateo, Alison Burdett, K Y Felice Leung, Jake Barnett, Arman Orbeladze, Song Luan, Stavros Pournias, Jiayang Sun, Barney Flower, Judith Bedzo-Nutakor, Maisarah Amran, Rachael Quinlan, Keira Skolimowska, Carolina Herrera, Aileen Rowan, Anjna Badhan, Robert Klaber, Gary Davies, David Muir, Paul Randell, Derrick Crook, Graham P Taylor, Wendy Barclay, Nabeela Mughal, Luke S P Moore, Katie Jeffery, Graham S Cooke
Journal: The Lancet Microbe (2020)

Access to rapid diagnosis is key to the control and management of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Laboratory RT-PCR testing is the current standard of care but usually requires a centralised laboratory and significant infrastructure. We describe our diagnostic accuracy assessment of a novel, rapid point-of-care real time RT-PCR CovidNudge test, which requires no laboratory handling or sample pre-processing.
Cell Membrane Wrapping: Influence of Cell Membrane Wrapping on the Cell−Porous Silicon Nanoparticle Interactions (Adv. Healthcare Mater. 17/2020)
Authors: Flavia Fontana, Hanna Lindstedt, Alexandra Correia, Jacopo Chiaro, Otto K. Kari, Joseph Ndika, Harri Alenius, Jonas Buck, Sandro Sieber, Ermei Mäkilä, Jarno Salonen, Arto Urtti, Vincenzo Cerullo, Jouni T. Hirvonen, Hélder A. Santos
Journal: Advanced Healthcare Materials (2020)
Covid-19: Government must fund extra NHS capacity to tackle backlog, BMA urges
Authors: Gareth Iacobucci
Journal: BMJ (2020)

BMA representatives have said that the government must fund extra NHS capacity to deal with the backlog of planned care caused by the covid-19 pandemic.

A motion passed by the association’s annual representative meeting, held virtually on Tuesday 15 September, noted the backlog of planned care resulting from the pandemic. Given the likely effect on NHS waiting lists, the motion called on the BMA to work with governments to develop a public information campaign on the likely timescale for the NHS to return to normal services.

Sakkaf Ahmed Aftab of the BMA’s Yorkshire Regional Council, who proposed the motion, outlined the seriousness of the backlog, highlighting estimates from the …
Corrigendum to “Co-delivery of all-trans-retinoic acid and doxorubicin for cancer therapy with synergistic inhibition of cancer stem cells” [Biomaterials 37 (2015) 405–414]
Authors: Rong Sun, Yang Liu, Shi-Yong Li, Song Shen, Xiao-Jiao Du, Cong-Fei Xu, Zhi-Ting Cao, Yan Bao, Yan-Hua Zhu, Ya-Ping Li, Xian-Zhu Yang, Jun Wang
Journal: Biomaterials (2020)
Author Correction: STEEP mediates STING ER exit and activation of signaling
Authors: Bao-cun Zhang, Ramya Nandakumar, Line S. Reinert, Jinrong Huang, Anders Laustsen, Zong-liang Gao, Cheng-long Sun, Søren Beck Jensen, Anne Troldborg, Sonia Assil, Martin F. Berthelsen, Carsten Scavenius, Yan Zhang, Samuel J. Windross, David Olagnier, Thaneas Prabakaran, Chiranjeevi Bodda, Ryo Narita, Yujia Cai, Cong-gang Zhang, Harald Stenmark, Christine M. Doucet, Takeshi Noda, Zheng Guo, Raphaela Goldbach-Mansky, Rune Hartmann, Zhijian J. Chen, Jan J. Enghild, Rasmus O. Bak, Martin K. Thomsen, Søren R. Paludan
Journal: Nature Immunology (2020)
Glial Metabolic Rewiring Promotes Axon Regeneration and Functional Recovery in the Central Nervous System
Authors: Feng Li, Armin Sami, Harun N. Noristani, Kieran Slattery, Jingyun Qiu, Thomas Groves, Shuo Wang, Kelly Veerasammy, Yuki X. Chen, Jorge Morales, Paula Haynes, Amita Sehgal, Ye He, Shuxin Li, Yuanquan Song
Journal: Cell Metabolism (2020)
Machine Learning-Based DNA Methylation Score for Fetal Exposure to Maternal Smoking: Development and Validation in Samples Collected from Adolescents and Adults
Authors: Sebastian Rauschert, Phillip E. Melton, Anni Heiskala, Ville Karhunen, Graham Burdge, Jeffrey M. Craig, Keith M. Godfrey, Karen Lillycrop, Trevor A. Mori, Lawrence J. Beilin, Wendy H. Oddy, Craig Pennell, Marjo-Riitta Järvelin, Sylvain Sebert, Rae-Chi Huang
Journal: Environmental Health Perspectives (2020)

Fetal exposure to maternal smoking during pregnancy is associated with the development of noncommunicable diseases in the offspring. Maternal smoking may induce such long-term effects through persistent changes in the DNA methylome, which therefore hold the potential to be used as a biomarker of this early life exposure. With declining costs for measuring DNA methylation, we aimed to develop a DNA methylation score that can be used on adolescent DNA methylation data and thereby generate a score for
Intense 99mTc-MDP Uptake in the Abdominal Soft Tissue Secondary to Subcutaneous Insulin Injection
Authors: Wenhui Fu, Chengrun Zeng, Tingting Xu, Xinyi Zhang, Yue Chen
Journal: Clinical Nuclear Medicine (2020)

Abstract A 65-year-old woman with known breast cancer presented with lower back pain over 1 month. Multiple sclerotic foci of increased tracer uptake in the bones were noted on the 99m Tc-MDP bone scintigraphy and SPECT/CT images, suggesting osteoblastic metastasis. Unexpectedly, symmetric 99m Tc-MDP activity was visualized in the soft tissue near the umbilical area, corresponding to the sites of insulin injection.
Blatant disregard to proper consent continues in screening programmes
Authors: Hazel Thornton
Journal: BMJ (2020)

Haskell tells us that the Cumberlege report found that the healthcare system was “disjointed, siloed, unresponsive, and defensive” and that it did “not adequately recognise that patients are its raison d’etre.”1 The findings were “generalisable across the healthcare system,” which the review found to be “sluggish and inattentive” and “unresponsive and defensive.”

Of deep concern is “the testimony from hundreds of patients reporting lack of …
Iron and Cancer: 2020 Vision
Authors: Suzy V. Torti, Frank M. Torti
Journal: Cancer Research (2020)

Abstract New and provocative insights into the relationships between iron and cancer have been uncovered in recent years. These include delineation of connections that link cellular iron to DNA repair, genomic integrity, and oncogenic signaling as well as the discovery of ferroptosis, a novel iron-dependent form of cell death. In parallel, new molecules and pathways that regulate iron influx, intracellular iron trafficking, and egress in normal cells, and their perturbations in cancer have been discovered. In addition, insights into the unique properties of iron handling in tumor-initiating cells (cancer stem cells), novel contributions of the tumor microenvironment to the uptake and regulation of iron in cancer cells, and new therapeutic modalities that leverage the iron dependence of cancer have emerged.
18F-FDG PET/CT of Hepatosplenic Actinomycosis After Laparoscopic Cystojejunostomy for Pancreatic Pseudocyst
Authors: Qiong Zou, Ju Jiao, Wei-min Liu, Ting Yang, Yong Zhang
Journal: Clinical Nuclear Medicine (2020)

We report the 18F-FDG PET/CT appearance of abdominal actinomycosis in a 48-year-old immunocompetent woman with a history of laparoscopic cystojejunostomy for pancreatic pseudocyst previously. 18F-FDG PET/CT demonstrated multiple hypermetabolism in the liver, spleen, cystojejunostomy anastomosis, greater omentum, and umbilical region. Actinomycosis was verified by biopsy. Hepatosplenic actinomycosis secondary to cystojejunostomy is extremely rare and easily to be misdiagnosed. PET/CT is helpful for auxiliary diagnosis, guiding biopsy, and exploring the extent of the disease.
Abstract 16372: Loss of Endothelial P300 Leads to Exacerbation of Pulmonary Hypertension
Authors: Sandy Lee, Katharine Clapham, Takaomi Adachi, Sameet Mehta, Hyung J Chun
Journal: Circulation (2018)

Introduction: Pulmonary arterial hypertension (PAH) is a progressive and ultimately life-limiting disease that is associated with dysregulated endothelial function. The epigenetic factor p300 is a ...
Diuretic Dose and NYHA Functional Class Are Independent Predictors of Mortality in Patients With Transthyretin Cardiac Amyloidosis
Authors: Richard K. Cheng, Wayne C. Levy, Alexi Vasbinder, Sergio Teruya, Jeffeny De Los Santos, Douglas Leedy, Mathew S. Maurer
Journal: JACC CardioOncology (2020)

With increasing diagnoses and available treatment options for transthyretin amyloidosis cardiomyopathy (ATTR-CM), risk stratification of ATTR-CM patients is imperative.We hypothesized that diuretic dose and New York Heart Association (NYHA) functional class are independent predictors of mortality in ATTR-CM and would be incrementally additive to existent risk scores.Consecutive ATTR-CM patients referred to a single center were identified. Adjusted Cox proportional hazards models determined the association between diuretic dose (furosemide equivalent in mg/kg) at time of diagnosis and the primary outcome of all-cause mortality. The incremental value of adding diuretic dose and NYHA functional class to existing ATTR-CM risk scores was assessed for discrimination and calibration.309 patients were identified, with mean age 73.2 ± 9.8 years, 84.1% male, and 66% wild type. Daily mean diuretic dose was 0.6 ± 1.0 mg/kg and significantly associated with all-cause mortality (unadjusted hazard ratio: 2.12 per 1-mg/kg increase, [95% confidence interval: 1.71 to 2.61] and fully adjusted hazard ratio: 1.43 [95% confidence interval: 1.06 to 1.93]). Testing previously published ATTR risk scores, adding diuretic dose as categories (0 mg/kg, >0 to 0.5 mg/kg, >0.5 to 1 mg/kg, and >1 to 2 mg/kg) improved the area under the curve of the Mayo risk score from 0.693 to 0.767 and the UK risk score from 0.711 to 0.787 while preserving calibration. Adding NYHA functional class further improved the area under the curve to 0.798 and 0.816, respectively.Diuretic dose and NYHA functional class are independent predictors of mortality in ATTR-CM patients and provide incremental value to existing ATTR-CM risk scores.
Adaptation of evidence‐based suicide prevention strategies during and after the <scp>COVID</scp>‐19 pandemic
Authors: Danuta Wasserman, Miriam Iosue, Anika Wuestefeld, Vladimir Carli
Journal: World Psychiatry (2020)

Suicide is preventable. Nevertheless, each year 800,000 people die of suicide in the world. While there is evidence indicating that suicide rates de-crease during times of crises, they are expected to increase once the immediate crisis has passed. The COVID-19 pandemic affects risk and pro-tective factors for suicide at each level of the socio-ecological model. Economic downturn, augmented barriers to accessing health care, increased access to suicidal means, inappropriate media reporting at the societal level; deprioritization of mental health and preventive activities at the community level; interpersonal conflicts, neglect and violence at the relationship level; unemployment, poverty, loneliness and hopelessness at the individual level: all these variables contribute to an increase of depression, anxiety, post-traumatic stress disorder, harmful use of alcohol, substance abuse, and ultimately suicide risk. Suicide should be prevented by strengthening universal strategies directed to the entire population, including mitigation of unemployment, poverty and inequalities; prioritization of access to mental health care; responsible media reporting, with information about available support; prevention of increased alcohol intake; and restriction of access to lethal means of suicide. Selective interventions should continue to target known vulnerable groups who are socio-economically disadvantaged, but also new ones such as first responders and health care staff, and the bereaved by COVID-19 who have been deprived of the final contact with loved ones and funerals. Indicated preventive strategies targeting individuals who display suicidal behaviour should focus on available pharmacological and psychological treatments of mental disorders, ensuring proper follow-up and chain of care by increased use of telemedicine and other digital means. The scientific community, health care professionals, politicians and decision-makers will find in this paper a systematic description of the effects of the pandemic on suicide risk at the society, community, family and individual levels, and an overview of how evidence-based suicide preventive interventions should be adapted. Research is needed to investigate which adaptations are effective and in which con-texts.
Bile acid-based dual-functional prodrug nanoparticles for bone regeneration through hydrogen peroxide scavenging and osteogenic differentiation of mesenchymal stem cells
Authors: Yoshie Arai, Hyoeun Park, Sunghyun Park, Dohyun Kim, Inho Baek, Lipjeong Jeong, Byoung Ju Kim, Kwideok Park, Dongwon Lee, Soo-Hong Lee
Journal: Journal of Controlled Release (2020)
Association of a Diagnosis of Ductal Carcinoma In Situ With Death From Breast Cancer
Authors: Vasily Giannakeas, Victoria Sopik, Steven A. Narod
Journal: JAMA Network Open (2020)

<h3>Importance</h3> It is not clear to what extent a diagnosis of ductal carcinoma in situ (DCIS) impacts a woman's lifetime risk of dying of breast cancer. Under ideal circumstances, treatment will eliminate the risk of invasive ipsilateral recurrence and prevent subsequent mortality from breast cancer. The risk of dying of breast cancer after a diagnosis of DCIS had not been compared with that of women without cancer in the general population. <h3>Objective</h3> To determine the risk of death from breast cancer in a large cohort of patients treated for DCIS and to compare the risk with that of women in the general population. <h3>Design, Setting, and Participants</h3> This cohort study included data for women who had first primary DCIS diagnosed between 1995 and 2014 from the Surveillance, Epidemiology and End Results (SEER) registries database. Women with DCIS underwent surgical treatment, and approximately half also received radiotherapy. These women were followed from the date of DCIS diagnosis until death from breast cancer or date of last follow-up. Women in the general population without breast cancer were analyzed as controls. Follow-up information was available up to December 2016. The data were analyzed in March 2020. <h3>Exposures</h3> Patients with DCIS who underwent surgical treatment. <h3>Main Outcomes and Measures</h3> Breast cancer death was the main outcome. Standardized mortality ratios were estimated by comparing deaths from breast cancer among women diagnosed with DCIS with expected deaths from breast cancer among women in the general population who did not have cancer. Expected probability of death from breast cancer in the general population was calculated by an incidence-based mortality approach using standardized SEER-based incidence and case-fatality rates. Probability of breast cancer death was estimated based on the assumption that a cancer-free control was cancer free on the date the woman with DCIS was diagnosed and was studied until the end of follow-up. <h3>Results</h3> A total of 144 524 women diagnosed with first primary DCIS were included (mean [SD] age at diagnosis, 57.4 [11.0] years). There were 1540 deaths from breast cancer in the cohort. Based on SEER-based incidence and case-fatality rates, 458 breast cancer deaths were expected in an equivalent number of cancer-free women from the general population with equal follow-up. The standardized mortality ratio for death from breast cancer among women with DCIS was 3.36 (95% CI, 3.20-3.53). The elevated risk of death persisted more than 15 years after diagnosis. <h3>Conclusions and Relevance</h3> In the population studied, the risk of dying of breast cancer was increased 3-fold after a diagnosis of DCIS. This suggests that our current treatment focus on preventing invasive recurrence is insufficient to eliminate all deaths from breast cancer after DCIS.
Apobec Family of Proteins Mediate Genomic Changes in Multiple Myeloma By Inducing DNA Damage and C>T Mutations
Authors: Srikanth Talluri, Mehmet Kemal Samur, Leutz Buon, Puru Nanjappa, Rao Prabhala, Masood A. Shammas, Nikhil Munshi
Journal: Blood (2017)
ID:1329 ORIENT-11: Sintilimab + Pemetrexed + Platinum as First-Line Therapy for Locally Advanced or Metastatic Non-Squamous NSCLC
Authors: L. Zhang, Y. Yang, Z. Wang, J. Fang, Q. Yu, B. Han, S. Cang, G. Chen, X. Mei, Z. Yang, R. Ma, M. Bi, X. Ren, J. Zhou, B. Li, W. Xu, Y. Ji, B. Peng
Journal: Journal of Thoracic Oncology (2020)