tbuckley/cabot-search huggingface dataset:
Year Book of Medicine 1962-1963 Series.
Journal: Annals of Internal Medicine (1962)

The American Right Wing, A Report to the Fund for the Republic, Inc., in University of Illinois Library School Occasional Papers, No. 59, November, 1960. By Ralph E. Ellsworth and Sarah M. Harris. Price, $1. Pp. 50, with no illustrations. University of Illinois Graduate School of Library Science, Chicago 12, 1960. The distribution curve of medical and political attitudes presents a fascinating spectrum with a bell-shaped cluster of the large majority near but not at the middle. But at either end far to the left and far to the right we have fringes, men who follow the one view or the other with such powerful passion that it distorts their thinking and confuses their attitudes. The distribution of the political and social views of physicians has an interesting hump towards the right. It is correlated in a general way with the natural conservatism of medical practice and the increased conservatism of older persons. The extreme right is characterized by reactionary elements who have failed to keep up with the shifting customs, the altered economic contexts, and the changed problems of contemporary existence. While the American Medical Association has often been the whipping boy for those who lean a little to the left, and many charges are empty, it is well to remember the equal but perhaps less obvious dangers which occur when those occupying the ex¬ treme right are willing to sacrifice constitu¬ tional guarantees of freedom in order to promulgate their own views, beliefs, and feelings. Professor Ralph Ellsworth and the late Dr. Sarah M. Harris have gathered together sources of all kinds indicating the activities, publications, and political pres¬ sures of both the orthodox conservative wing and the rabid and morbid edges where
Phase I Study of 5-aza-2′-Deoxycitidine, Alone or in Combination with Hyper-CVAD, in Relapsed or Refractory Acute Lymphocytic Leukemia (ALL).
Authors: Guillermo Garcia-Manero, Deborah Thomas, Michael Rytting, Patrick Zweidler-McKay, Zeev Estrov, Devri L. Brown, Hui Yang, Hagop Kantarjian, Susan O’Brien
Journal: Blood (2007)
Assisted dying methods can lead to “inhumane” deaths
Authors: Ingrid Torjesen
Journal: BMJ (2019)

Methods for assisting death in countries where the practice is legal do not reliably achieve unconsciousness at the time of death to ensure that the patient experiences no pain or distress, a review published in the journal Anaesthesia has found.1

An argument made in support of assisted dying is that it minimises patients’ pain and distress and allows them to die with dignity at a time and place of their choosing. This argument assumes that the methods used are always effective in their aim of producing unconsciousness and death quickly, but an international group of researchers reviewed the …
Repeated Transfusion of Granulocytes to Control Multidrug-Resistant Pseudomonas Aeruginosa Sepsis in Haploidentical Hematopoietic Stem Cell Transplant Patients during Pre-Engraftment Stage
Authors: Yixin Hu, Ruonan Sun, Jun Lu, Peifang Xiao, Jie Li, Defei Zheng, Shaoyan Hu
Journal: Blood (2018)
Foodborne Illness Outbreaks at Retail Establishments — National Environmental Assessment Reporting System, 16 State and Local Health Departments, 2014–2016
Authors: Lauren E. Lipcsei, Laura G. Brown, Erik W. Coleman, Adam Kramer, Matthew Masters, Beth C. Wittry, Kirsten Reed, Vincent J. Radke
Journal: MMWR Surveillance Summaries (2019)

State and local public health departments report hundreds of foodborne illness outbreaks each year to CDC and are primarily responsible for investigations of these outbreaks. Typically, investigations involve epidemiology, laboratory, and environmental health components. Health departments voluntarily report epidemiologic and laboratory data from their foodborne illness outbreak investigations to CDC through the Foodborne Disease Outbreak Surveillance System (FDOSS); however, minimal environmental health data from outbreak investigations are reported to FDOSS.
Correction
Authors: Chang Hoon Lee, Mark Melchers, Hongsheng Wang, Ted A. Torrey, Rebecca Slota, Chen-Feng Qi, Ji Young Kim, Patricia Lugar, Hee Jeong Kong, Lila Farrington, Boris van der Zouwen, Jeff X. Zhou, Vassilios Lougaris, Peter E. Lipsky, Amrie C. Grammer, Herbert C. Morse
Journal: The Journal of Experimental Medicine (2006)
Combination of exercise and calorie restriction exerts greater efficacy on cardioprotection than monotherapy in obese-insulin resistant rats through the improvement of cardiac calcium regulation
Authors: Siripong Palee, Wanitchaya Minta, Duangkamol Mantor, Wissuta Sutham, Thidarat Jaiwongkam, Sasiwan Kerdphoo, Wasana Pratchayasakul, Siriporn C. Chattipakorn, Nipon Chattipakorn
Journal: Metabolism (2019)
Identification of Self-Limiting Pediatric Immune Thrombocytopenia at Diagnosis
Authors: David Schmidt, Katja Heitink-Pollé, Bart Mertens, Annemieke G. Laarhoven, Leendert Porcelijn, Barbera Veldhuisen, C. Ellen van der Schoot, Gestur Vidarsson, Johanna G van der Bom, Marrie Bruin, Masja De Haas
Journal: Blood (2018)
Reply to Marruchella: Preserved Ratio Impaired Spirometry and Interstitial Lung Abnormalities in Smokers
Authors: Emily S. Wan, Edwin K. Silverman
Journal: American Journal of Respiratory and Critical Care Medicine (2019)

I read with great interest the paper by Wan and coworkers evaluating the preserved ratio impaired spirometry (PRISm) functional pattern (FEV 1 /FVC > 0.7 and FEV 1 .80%) in their longitudinal study of a large cohort of current or ex-smokers (1).The prevalence of this heterogeneous condition is remarkable (12.4% and 12.5% at baseline and follow-up, respectively) and its association with increased mortality, comparable to that observed in Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2 subjects, deserves special consideration.Individuals with PRISm are characterized by a significantly lower TLC% predicted and percent emphysema, as measured on quantitative computed tomography scans, in comparison with GOLD 0 and GOLD 1-4 groups.In the study cohort, the PRISm status was not stable at 5-year follow-up; in particular, the authors report a transition to GOLD 0 in 22% of the subjects with PRISm and a transition to PRISm in about one-third of baseline GOLD 0 individuals.The latter group was characterized by a lesser amount of emphysema and air trapping on computed tomography scans, an increase in body mass index, and decreased TLC% predicted and percent emphysema at baseline.Moreover, this group exhibited the largest functional decline (either FEV 1 or FVC) in comparison with all other groups, suggesting a restrictive physiologic impairment.Interstitial lung abnormalities have been found in a substantial minority of a cohort of smokers enrolled in the COPDGene (Genetic Epidemiology of Chronic Obstructive Pulmonary Disease) study (1 out of 12) and were associated with a reduced TLC and a lesser amount of emphysema.Smokers with interstitial lung abnormalities were more likely to have an "unclassified" spirometric pattern, analogous to PRISm (2).Under this definition are grouped various morphological pictures that may represent static imaging findings or the early stage of a progressive fibrosing disease (3).The evidence of many similarities between smokers identified as carriers of interstitial lung abnormalities and those functionally classified as having PRISm makes me think that at least a small subset of baseline GOLD 0 subjects who transitioned to the PRISm group could have developed a smoke-related interstitial disorder.
The IMWG Frailty Score and Age Can be More Effective Than Clinical Judgement in the Selection of Elderly Patients with Newly Diagnosed Multiple Myeloma Who Can Benefit from an Intensive Treatment Approach with High Dose Melphalan and Autologous Stem Cell Transplantation
Authors: Angelo Belotti, Rossella Ribolla, Valeria Cancelli, Nicola Bianchetti, Claudia Crippa, Samantha Ferrari, Chiara Bottelli, Chiara Cattaneo, Vincenza Orlando, Marco Chiarini, Luigi Grazioli, Giuseppe Rossi
Journal: Blood (2018)
In-Hospital Initiation of Angiotensin Receptor-Neprilysin Inhibitors—The Time Is Now
Authors: Pratyaksh K. Srivastava, Gregg C. Fonarow
Journal: JAMA Cardiology (2019)

This Viewpoint describes randomized clinical trial data supporting the use of angiotensin receptor-neprilysin inhibitor medications as an alternative to angiotensin-converting enzyme medication regimens.
Executive Summary: Heart Disease and Stroke Statistics—2016 Update
Authors: Dariush Mozaffarian, Emelia J. Benjamin, Alan S. Go, Donna K. Arnett, Michael J. Blaha, Mary Cushman, Sandeep R. Das, Sarah de Ferranti, Jean-Pierre Després, Heather J. Fullerton, Virginia J. Howard, Mark D. Huffman, Carmen R. Isasi, Monik C. Jiménez, Suzanne E. Judd, Brett M. Kissela, Judith H. Lichtman, Lynda D. Lisabeth, Simin Liu, Rachel H. Mackey, David J. Magid, Darren K. McGuire, Emile R. Mohler, Claudia S. Moy, Paul Muntner, Michael E. Mussolino, Khurram Nasir, Robert W. Neumar, Graham Nichol, Latha Palaniappan, Dilip K. Pandey, Mathew J. Reeves, Carlos J. Rodriguez, Wayne Rosamond, Paul D. Sorlie, Joel Stein, Amytis Towfighi, Tanya N. Turan, Salim S. Virani, Daniel Woo, Robert W. Yeh, Melanie B. Turner
Journal: Circulation (2016)
Silibinin ameliorates hepatic lipid accumulation and oxidative stress in mice with non-alcoholic steatohepatitis by regulating CFLAR-JNK pathway
Authors: Yayun Liu, Wei Xu, Ting Zhai, Jiaojiao You, Yong Chen
Journal: Acta Pharmaceutica Sinica B (2019)

Non-alcoholic steatohepatitis (NASH) is a chronic metabolic syndrome and the CFLAR-JNK pathway can reverse the process of NASH. Although silibinin is used for the treatment of NASH in clinical, its effect on CFLAR-JNK pathway in NASH remains unclear. This study aimed to investigate the effect of silibinin on CFLAR-JNK pathway in NASH models both in vivo and in vitro. The in vivo study was performed using male C57BL/6 mice fed with methionine- choline-deficient diet and simultaneously treated with silibinin for 6 weeks. The in vitro study was performed by using mouse NCTC-1469 cells which were respectively pretreated with oleic acid plus palmitic acid, and adenovirus-down Cflar for 24 h, then treated with silibinin for 24 h. After the drug treatment, the key indicators involved in CFLAR-JNK pathway including hepatic injury, lipid metabolism and oxidative stress were determined. Silibinin significantly activated CFLAR and inhibited the phosphorylation of JNK, up-regulated the mRNA expression of Pparα, Fabp5, Cpt1α, Acox, Scd-1, Gpat and Mttp, reduced the activities of serum ALT and AST and the contents of hepatic TG, TC and MDA, increased the expression of NRF2 and the activities of CAT, GSH-Px and HO-1, and decreased the activities and expression of CYP2E1 and CYP4A in vivo. These effects were confirmed by the in vitro experiments. Silibinin prevented NASH by regulating CFLAR-JNK pathway, and thereby on one hand promoting the β-oxidation and efflux of fatty acids in liver to relieve lipid accumulation, and on the other hand inducing antioxidase activity (CAT, GSH-Px and HO-1) and inhibiting pro-oxidase activity (CYP2E1 and CYP4A) to relieve oxidative stress.
Identifying Novel Sepsis Subphenotypes Using Temperature Trajectories
Authors: Sivasubramanium V. Bhavani, Kyle A. Carey, Emily R. Gilbert, Majid Afshar, Philip A. Verhoef, Matthew M. Churpek
Journal: American Journal of Respiratory and Critical Care Medicine (2019)

Sepsis is a heterogeneous syndrome, and identifying clinically relevant subphenotypes is essential.
Abstract 3020: Novel therapeutic targets in head and neck cancer
Authors: Maria Kondratyev, Aleksandra Pesic, Troy Ketela, Azin Sayad, Stephano Marastoni, Carl Virtanen, Laurie Ailles, Soroush Samadian, Mikhail Bashkurov, Marianne Koritzinsky, Brad Wouters
Journal: Cancer Research (2017)

Abstract HNSCC is 6th most common malignancy in the world. Despite advances in diagnosis and treatment, the survival rates remain low due to frequent recurrences the biology of which remains unclear. Using functional genomic technologies, we identified new therapeutic targets for metastatic disease in HNSCC. Whole genome shRNA screens were conducted in matched sets of cell lines derived from primary tumors and respective metastatic sites, identifying genes essential for cell survival only following metastasis. To test if knockdown of selected targets inhibits metastasis in a therapeutic setting, we established orthotropic model of HNSCC that metastasize to lymph nodes in the mouse. Components of Notch pathway were identified as essential for survival of cells derived from metastatic sites. Whole exome sequencing identified a novel mutation in one of the EGF domains of Notch3 that was acquired only in the metastatic line. Utilizing CRISPR methodology, we established that “fixing” the mutation results in reversal of metastatic phenotype of the cells, making them Notch independent similar to their primary tumor counterparts. Mutations in EGF domains have been reported to influence interaction with specific ligands, dictating which ligand can activate Notch signaling. Our data indicate that a distinct set of target genes is induced upon interaction between Notch3 and Jag2 ligand. Furthermore, our results indicate that suppression of Notch3 improves survival in mice bearing orthotropic tumors derived from the metastatic HNSCC lines. Overall, our data demonstrate that metastatic cells from head and neck tumors acquire dependency on Notch3 signaling. Novel treatments targeting components of this pathway may prove effective in targeting metastatic cells alone or in combination with conventional therapies. Citation Format: Maria Kondratyev, Aleksandra Pesic, Troy Ketela, Azin Sayad, Stephano Marastoni, Carl Virtanen, Laurie Ailles, Soroush Samadian, Mikhail Bashkurov, Marianne Koritzinsky, Brad Wouters. Novel therapeutic targets in head and neck cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3020. doi:10.1158/1538-7445.AM2017-3020
Association of Adolescent Hypertension With Future End-stage Renal Disease
Authors: Adi Leiba, Boris Fishman, Gilad Twig, David Gilad, Estela Derazne, Ari Shamiss, Tamar Shohat, Ofir Ron, Ehud Grossman
Journal: JAMA Internal Medicine (2019)

Hypertension is a leading risk factor of cardiovascular morbidity and mortality. The role of nonmalignant hypertension as the sole initiating factor of end-stage renal disease (ESRD) in non-African American populations has recently been questioned.To investigate the association between hypertension and future ESRD in otherwise healthy adolescents.This retrospective cohort study examined the data of 16- to 19-year-old healthy candidates for military service in the Israel Defense Forces between January 1, 1967, and December 31, 2013. Data were obtained from the central conscription registry of the Israel Defense Forces and the ESRD registry of the Israel Ministry of Health. Participants underwent a comprehensive medical assessment prior to their military service. Individuals with evidence of renal damage or kidney-related risk factors were excluded. The data analysis was conducted from February 12, 2017, to October 16, 2018.End-stage renal disease as recorded by the Israeli ESRD registry, including hemodialysis, peritoneal dialysis, renal transplant diagnosed between January 1, 1990, and December 31, 2014.The cohort included 2 658 238 adolescents (1 596 709 [60.1%] male with a mean [SD] age of 17.4 [0.5] years), of whom 7997 (0.3%) had an established hypertension diagnosis. Half of the individuals in the hypertensive group were overweight (1559 [20.1%]) or obese (2243 [28.9%]), and most (7235 [90.5%]) were male. During a median follow-up of 19.6 years (52 287 945 person-years), 2189 individuals developed ESRD, with an incidence rate of 3.9 per 100 000 person-years. Adolescent hypertension was found to be associated with future ESRD (crude hazard ratio [HR], 5.07; 95% CI, 3.73-6.88). In a multivariable model adjusted for sex, age, years of education, body mass index, and other sociodemographic variables, the HR was 1.98 (95% CI, 1.42-2.77). When excluding participants with severe hypertension, the association with ESRD remained statistically significant (HR, 1.93; 95% CI, 1.37-2.70). In the subanalysis of nonoverweight adolescents, the association between hypertension and ESRD was statistically significant as well (HR, 2.11; 95% CI, 1.05-4.24).Hypertension appears to be associated with a doubling of the risk of future ESRD in an otherwise healthy adolescent population.
Outcomes for Older Patients with Acute Myeloid Leukemia after Admission to the Intensive Care Unit (ICU)
Authors: Samuel Slavin, Andrew M. Brunner, David P. Steensma, Amir T. Fathi, Daniel J. DeAngelo, Martha Wadleigh, Gabriela S. Hobbs, Philip C. Amrein, Richard M. Stone, Jennifer S Temel, Gregory A. Abel, Areej El-Jawahri
Journal: Blood (2018)
A Consistent Backbone for the Fungi
Authors: Ingo Ebersberger, Arndt Von Haeseler
Journal: Molecular Biology and Evolution (2012)

The kingdom of fungi provides model organisms for biotechnology, cell biology, genetics, and life sciences in general. Only when their phylogenetic relationships are stably resolved, can individual results from fungal research be integrated into a holistic picture of biology. However, and despite recent progress, many deep relationships within the fungi remain unclear. Here, we present the first phylogenomic study of an entire eukaryotic kingdom that uses a consistency criterion to strengthen phylogenetic conclusions. We reason that branches (splits) recovered with independent data and different tree reconstruction methods are likely to reflect true evolutionary relationships. Two complementary phylogenomic data sets based on 99 fungal genomes and 109 fungal expressed sequence tag (EST) sets analyzed with four different tree reconstruction methods shed light from different angles on the fungal tree of life. Eleven additional data sets address specifically the phylogenetic position of Blastocladiomycota, Ustilaginomycotina, and Dothideomycetes, respectively. The combined evidence from the resulting trees supports the deep-level stability of the fungal groups toward a comprehensive natural system of the fungi. In addition, our analysis reveals methodologically interesting aspects. Enrichment for EST encoded data—a common practice in phylogenomic analyses—introduces a strong bias toward slowly evolving and functionally correlated genes. Consequently, the generalization of phylogenomic data sets as collections of randomly selected genes cannot be taken for granted. A thorough characterization of the data to assess possible influences on the tree reconstruction should therefore become a standard in phylogenomic analyses.
(13) Muir-Torre syndrome
Authors: I.H. Coulson, K.V. Sanderson
Journal: British Journal of Dermatology (1985)

Journal Article (13) Muir‐Torre syndrome Get access I.H. Coulson, I.H. Coulson Royal Marsden Hospital, London SW3 Search for other works by this author on: Oxford Academic Google Scholar K.V. Sanderson K.V. Sanderson Royal Marsden Hospital, London SW3 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 113, Issue s29, 1 July 1985, Pages 57–58, https://doi.org/10.1111/j.1365-2133.1985.tb13028.x Published: 01 July 1985
Characteristics of High Cardiovascular Risk in 1.7 Million Chinese Adults
Authors: Jiapeng Lu, Yuan Lu, Hao Yang, Wuhan Bilige, Yetong Li, Wade Schulz, Frederick A. Masoudi, Harlan M. Krumholz
Journal: Annals of Internal Medicine (2019)

As cardiovascular risk increases in China, interest in strategies to mitigate it is growing. However, national information about the prevalence and treatment of high cardiovascular disease (CVD) risk is limited.To assess the prevalence and treatment of high CVD risk as well as variations in risk across population subgroups.National project of CVD screening and management.141 county-level regions in all 31 provinces of China.Local residents aged 35 to 75 years.Rates of high CVD risk were assessed both in the overall study population and by age, sex, body mass index, geographic region, and socioeconomic status. Multivariable mixed models were fitted to assess the associations between individual characteristics and high CVD risk. Statin and aspirin use was evaluated among persons at high risk for CVD.Among 1 680 126 participants, 9.5% (95% CI, 9.5% to 9.6%) had high risk for CVD. Mixed models identified persons who were of Han ethnicity, had medical insurance, were currently using alcohol, or were obese as more likely to be at high risk for CVD. Of those with high CVD risk, only 0.6% (CI, 0.5% to 0.6%) and 2.4% (CI, 2.3% to 2.5%) reported using statins and aspirin, respectively. Among persons with high CVD risk and hypertension, 31.8% were receiving antihypertensive medications.Samples were not nationally representative.Of the 1.7 million participants, 1 in 10 had a high risk for CVD; among those at high risk, fewer than 3% were receiving statins or aspirin. An immense opportunity exists for risk mitigation in this substantial population.Ministry of Finance and National Health Commission, China.