tbuckley/cabot-search huggingface dataset:
WHEN ENDOSCOPY PULLS CHESTNUTS OUT OF THE FIRE: A RARE CASE OF MIRIZZI´S SYNDROME TREATED WITH LASER LITHOTRIPSY BY DIRECT PERORAL CHOLANGIOSCOPY
Authors: R Di Mitri, F Mocciaro, D Scimeca, A Bonaccorso, E Conte, ML Mastro
Journal: Endoscopy (2020)

Aim We present a case of Mirizzi syndrome treated conservatively using laser lithotripsy by direct peroral cholangioscopy.
DYSPHAGIA ASSOCIATED WITH MOTILITY DISORDERS AFTER ANTI-REFLUX SURGERY: A NEW PROMISING THERAPEUTIC FIELD OF APPLICATION FOR POEM!
Authors: JM Gonzalez, L Monino, P Ah-Soune, V Vitton, M Barthet
Journal: Endoscopy (2020)

Aims Laparoscopic fundoplication (LF) is the gold standard treatment of refractory gastro-esophageal reflux (GERD). However, it may induce dysphagia in 5 to 10% of the cases. LF could induce de novo esophageal motility disorder (EMD) in 20% of the patients, inducing severe dysphagia and impaired quality of life. The management is difficult since 15% require surgical revision. Our objectives were to evaluate the efficacy of POEM on dysphagia, and to document the technical particularities and the complications
SAFETY OF DEEP SEDATION WITH PROPOFOL IN PATIENTS ASA III
Authors: L Medina-Prado, JM Sempere, S Baile-Maxía, M Bozhychko, C Mangas-Sanjuán, L Compañy, Francisco Ruiz, JR Aparicio, JA Casellas
Journal: Endoscopy (2020)

Aims To assess the safety of deep sedation with propofol controlled by the usual endoscopy team (doctor, nurse, assistant) in ambulant patients ASA III. – To analyse the risk factors for the occurrence of complications during deep sedation in these patients. – To assess the effect of the use of CPAP in patients with OSAS on the occurrence of complications.
Diabetes and pregnancy
Authors: Alison Macfarlane, Derek Tuffnell
Journal: BMJ (2006)

The evidence that rates of type 2 diabetes in pregnancy are rising is largely based on global figures and individual clinicians reports of younger pregnant women with the condition. Until recently care for women with diabetes in pregnancy has focused on type 1 diabetes. A paper in this weeks BMJ finds that high rates of congenital anomalies stillbirth and neonatal death were reported in women with type 2 diabetes as well as those with type 1 diabetes. Data on trends and variations in prevalence in pregnancy are sparse and based largely on indigenous and migrant populations in North America and New Zealand. Comparisons between studies are difficult as inclusion criteria are inconsistent. Studies vary according to whether they count miscarriages or terminations in their adverse outcomes and whether they include women who are diagnosed as having diabetes in pregnancy and are subsequently found to have type 2 diabetes. Migration of women from countries in Africa and South Asia with high rates of type 2 diabetes has increased the observed prevalence in western European and North American countries; consequent lifestyle changes may have compounded this increased prevalence.  (excerpt)
Blood Pressure Response to Oral Calcium in Persons with Mild to Moderate Hypertension
Authors: David A. Mccarron, Cynthia D. Morris
Journal: Annals of Internal Medicine (2020)

Abstract The blood pressure response of 48 hypertensive persons and 32 normotensive persons to elemental calcium (as the carbonate or citrate salt), 1000 mg/d for 8 weeks, was assessed in a randomi...
Letter to the Editor: Response to Letter Concerning Our Pregnancy Manuscript
Authors: Lisa Casey, Ariel Aday, Jody Rule, William M. Lee
Journal: Hepatology (2020)

Potential conflict of interest: Dr. Lee consults for Forma Therapeutics, Affibody, and Karuna. TO THE EDITOR: We are pleased to respond to Dr. Devarbhavi’s observations on our recent paper.(1) Regarding severity of disease, of the 70 cases described in our study, the vast majority (90%) were acute liver failure (ALF) on presentation; only 6 initially presented with acute liver injury, that is, international normalized ratio ≥ 2.0, but no encephalopathy. Recall that only 35 of 70 were pregnancy‐associated acute liver disease (PAALD) in any case. We agree that timely delivery is the first line of defense; however, as we pointed out, all patients had been delivered before enrollment in our study. Postpartum hepatology consultation is multifactorial: the emergent nature of the deliveries, life‐threatening status of the patients, and the assumption of improvement leads to postponing hepatology consultation until it is apparent that liver failure does not resolve. We would propose that hemolysis, elevated liver enzymes, low platelets (HELLP), featuring periportal hemorrhage, accounts for the vast majority of hepatic hematomas and rupture, not acute fatty liver of pregnancy (AFLP). Our paper did suggest that the distinction between the two can be hard to discern. We used the Acute Liver Failure Study Group Prognostic Index but not the Model for End‐Stage Liver Disease (MELD). MELD was not as effective as the prognostic index.(2) For the 35 PAALD patients in the present study, the difference between the median MELD score of those who survived (MELD = 28) and those who died or required a transplant (MELD = 32) were different but not statistically significant. The retrospective study by Dr. Devarbhavi and his colleagues warrants consideration, although the population in Bangalore likely differs greatly from a North American population.(3) For example, the overall mortality of 25% for PAALD in the referenced retrospective study contrasts sharply with that for our series, 11%, reflecting both different study design and patient population. We are not sure where the figure of 30% and 20% comes from in this context. Our PAALD cohort had an 11.4% mortality. Most of those who have pre‐eclampsia, HELLP, or AFLP resolve promptly with delivery; early resolutions were not represented in our study. Thus, it is hard to determine how many total patients with PAALD there are versus how many progress or fail to resolve. Our aim was also to highlight how many non‐PAALD liver diseases present during pregnancy. Finally, we have little experience with PDFF as a measure of AFLP severity in the postpartum setting. A limitation of most multicenter studies, including our own, is the inconsistency of diagnostic and treatment protocols across diverse institutions. In addition, our study took place across a 21‐year time span. Dr. Devarbhavi’s letter allowed us to revisit our own study and gain new insights—we appreciate the thoughtful comments provided.
Focused ultrasound for opening blood-brain barrier and drug delivery monitored with positron emission tomography
Authors: Wejdan M. Arif, Philip H. Elsinga, Carmen Gasca-Salas, Michel Versluis, Raul Martínez-Fernández, Rudi A.J.O. Dierckx, Ronald J.H. Borra, Gert Luurtsema
Journal: Journal of Controlled Release (2020)

Focused ultrasound (FUS) is a minimally-invasive technology used for treatment of many diseases, including diseases related to the colon, uterus, prostate, and brain. Although it has been mainly used for ablative procedures, the ability of FUS to open the blood-brain barrier (BBB) presents a promising new application. However, the mechanism of BBB opening by FUS remains unclear. This review focuses on the use of FUS to open the BBB for enhancing drug delivery and investigating how Positron Emission Tomography (PET) provides insight into the underlying mechanism.
FIBROTIC ANORECTAL STRICTURE COMPLICATING CROHN’S DISEASE IN A YOUNG WOMAN TREATED WITH BALLOON DILATION
Authors: J Maceček, B Staňka
Journal: Endoscopy (2020)

Anorectal stricture is a serious complication associated with Crohn’s disease. Strictures are usually inflammatory (S1) or fibrotic (S2). There is no specific antifibrotic therapy. Bowel resection or stricturoplasty were the preferred treatment approach with serious adverse events occurring after operation. Today, a variety of endoscopic approaches for the treatment of strictures are being used such as balloon or bougies dilation with local steroid injection and needle-knife stricturotomy. We present a video case report of a 30-year-old woman with S2 anorectal stricture, treated with balloon dilation with long lasting effect after four procedures without early or late complications.
NON-SPECIFIC UPPER GI MURAL THICKENING ON CT - IS IT JUST FROM PERISTALSIS?
Authors: R Patel, R Poonawala, R Khurram, N Jain, K Besherdas
Journal: Endoscopy (2020)

Aims British Society of Gastroenterology (BSG) guidance on the indications for diagnostic endoscopy include ‘abnormal findings on CT imaging’. Non-specific upper GI mural thickening on CT is a common abnormal finding raising the suspicion of malignancy. The correlation between CT mural thickening in the upper GI tract and endoscopic diagnosis of malignancy is not clearly known.
Quantitative Results of a National Intervention to Prevent Hospital-Acquired Catheter-Associated Urinary Tract Infection
Authors: Jennifer Meddings, Milisa Manojlovich, Jessica M. Ameling, Russell N. Olmsted, Andrew J. Rolle, M. Todd Greene, David Ratz, Ashley Snyder, Sanjay Saint
Journal: Annals of Internal Medicine (2019)

Background: Many hospitals struggle to prevent catheter-associated urinary tract infection (CAUTI). Objective: To evaluate the effect of a multimodal initiative on CAUTI in hospitals with high burd...
In ischemic stroke with viable hypoperfused tissue, alteplase &gt; 4.5 h after last seen well improves function
Authors: Michael D. Hill
Journal: Annals of Internal Medicine (2020)

Tsivgoulis G, Katsanos AH, Malhotra K, et al. Thrombolysis for acute ischemic stroke in the unwitnessed or extended therapeutic time window. Neurology. 2020;94:e1241-8. 31892636.
ELASTOGRAPHY GUIDED FINE NEEDLE VERSUS STANDARD FINE NEEDLE ASPIRATION IN SOLID PANCREATIC LESIONS: A PROSPECTIVE STUDY
Authors: A Seicean, M Gheorghiu, C Pojoga, O Mosteanu, I Rusu, NA Hajjar, R Seicean
Journal: Endoscopy (2020)

Aims To assess if the E-EUS-FNA is superior to standard EUS-FNA in obtaining specific diagnosis in solid pancreatic masses and the factors that can lead to different diagnostic rate.
ENDOSCOPIC ANALYSIS OF MICROSTRUCTURES OF THE COLON MUCOSA ON THE EDGE OF THE POST-RESECTION DEFECT AS A MEASURE OF PREVENTING RECURRENCE OF POLYPS AFTER POLYPECTOMY
Authors: N Ageykina, E Fedorov, N Oleynikova, P Malkov, N Danilova, O Kharlova
Journal: Endoscopy (2020)

Aims To assess the usefulness of cold polypectomy of small colon polyps on the basis of endoscopic microstructural analysis of the edges of the post-resection defect.
NEW UNDERWATER CAP-ASSISTED TECHNIQUE FOR ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY (ERCP) IN A PATIENT WITH SURGICALLY ALTERED ANATOMY
Authors: A Fugazza, M Badalamenti, D Paduano, S Carrara, R Maselli, G Pellegatta, FE Chiara, M Di Leo, PA Galtieri, V Craviotto, M Spadaccini, L Lamonaca, A Capogreco, A Anderloni, A Repici
Journal: Endoscopy (2020)

Background ERCP-rate in surgically-altered-anatomy (SAA) patients has increased. Given the difficulty to reach the papilla/the complicated angulation, treating SAA-patients is challenging. The used approaches are transmural-accesses (EUS-guided) and transluminal-access (enteroscope-mediated). ERCP-success-rate in SAA patients is low.
Contextual Errors and Failures in Individualizing Patient Care
Authors: Saul J. Weiner, Alan Schwartz, Frances Weaver, Julie Goldberg, Rachel Yudkowsky, Gunjan Sharma, Amy Binns-Calvey, Ben Preyss, Marilyn M. Schapira, Stephen D. Persell, Elizabeth Jacobs, Richard I. Abrams
Journal: Annals of Internal Medicine (2010)

This study had standardized patients present to physicians and report a medical problem with and without complicating factors. Complicating factors could be contextual, such as a recent loss of med...
EFFECTIVENESS AND SAFETY OF NER1006 VERSUS STANDARD BOWEL PREPARATIONS: A META-ANALYSIS OF PHASE-3 RANDOMISED CONTROLLED TRIALS
Authors: M Maida, FS Macaluso, E Sinagra, M Ventimiglia
Journal: Endoscopy (2020)

Aims We conducted a meta-analysis of randomised controlled trials (RCTs) to explore cleansing success, adenoma detection rate (ADR), and safety of NER1006 (Plenvu Norgine, Harefield, UK) versus standard bowel preparations.
Emerging Attack and Management Strategies for Nuclear Medicine in Responding to COVID-19—ACNM Member Experience and Advice
Authors: Yang Lu, Xiaohua Zhu, Sean Xuexian Yan, Xiaoli Lan
Journal: Clinical Nuclear Medicine (2020)

Abstract As the World Health Organization declared COVID-19 as “global pandemic,” it is important for everyone, including nuclear medicine personnel, to know how to stop transmission, contain, and prevent the spread of COVID-19. We reach out to our ACNM (American College of Nuclear Medicine) international members from Wuhan, China and Singapore, who have participated in dealing with COVID-19 for the last 2 months, to learn from their lessons and experiences, so to provide advice to all ACNM members for their clinical practice and management strategies in responding to COVID-19.
Subcutaneous Selatogrel Inhibits Platelet Aggregation in Patients With Acute Myocardial Infarction
Authors: Peter Sinnaeve, Gregor Fahrni, Dan Schelfaut, Alessandro Spirito, Christian Mueller, Jean-Marie Frenoux, Abdel Hmissi, Corine Bernaud, Mike Ufer, Tiziano Moccetti, Shaul Atar, Marco Valgimigli
Journal: Journal of the American College of Cardiology (2020)
SAFETY OF NER1006 IN ELDERLY: A POST-HOC ANALYSIS OF A PROSPECTIVE, MULTICENTER COHORT
Authors: M Maida, S Sferrazza, E Sinagra, G Morreale, G Scalisi, D Schillaci, G Vettori, G Conoscenti, C Di Bartolo, D Catarrella, S Garufi, M Manganaro, CM Virgilio, S Camilleri
Journal: Endoscopy (2020)

Aims This study aimed to assess the difference of NER1006 (Plenvu Norgine, Harefield, UK) safety profile in elderly compared to younger patients in a real-life setting.
MANAGEMENT OF STRICTURES AFTER ENDOSCOPIC RESECTION FOR EARLY ESOPHAGEAL NEOPLASIA
Authors: EA Ali, A Belle, S Leblanc, S Dermine, Lola-Ja Palmieri, M Dhooge, F Prat, R Coriat, S Chaussade, M Barret
Journal: Endoscopy (2020)

Aims Most available data on the management of post endoscopic resection strictures involve Japanese patients. Our study aims to describe the management of post endoscopic esophageal strictures following endoscopic submucosal dissection (ESD) or mucosal resection (EMR) for early esophageal cancers at a Western center.
BOWEL PREPARATION QUALITY: A CHALLENGE FOR EVERYONE?
Authors: M Hipólito, J Monteiro, MJ Magalhães, H Cardoso, S Santos, A Castro, S Santos, D Leite, A Moreira
Journal: Endoscopy (2020)

Aims It´s important to know the factors affecting an adequate bowel preparation such as co-morbidities, split-dose regimens, the overall tolerability, among others. The aim of this pilot study is to evaluate if bowel preparation quality is improved after applying enhanced instructions before colonoscopy, such as nursing phone calls, delivery of leaflets about bowel preparation and clarification of doubts for patient training.
ASSOCIATION BETWEEN ADHERENCE TO GLUTEN-FREE DIET AND DUODENAL VILLUS RECOVERY ON ENDOSCOPY, IN PATIENTS WITH CELIAC DISEASE AND SEVERE DUODENAL ATROPHY FOR OVER 10 YEARS
Authors: A Shiratori, G Bonatto, V Sagae, E Munaro, M Bonatto
Journal: Endoscopy (2020)

Aims To evaluate the association between GFD and the recovery of SDA in patients with CD for over 10 years according to EGD criteria, confirmed on histology and serology.
The general factor of psychopathology: a comparison with the general factor of intelligence with respect to magnitude and predictive validity
Authors: Erik Pettersson, Henrik Larsson, Brian M. D'Onofrio, Sven Bölte, Paul Lichtenstein
Journal: World Psychiatry (2020)

In recent years, there has been a surge of interest in the general factor of psychopathology ("p"), which is intended to summarize broad psychiat-ric comorbidity into a single index. In this study, rather than attempting to validate this model using statistical techniques, we compared the magnitude (as indicated by the variance explained in the respective indicators) and the predictive validity of the "p" factor with those of the gen-eral factor of intelligence ("g"). To compare the magnitude, for "g", we analyzed fifteen Wechsler Adult Intelligence Scale subtests (N=1,200). For "p", we analyzed fourteen psychiatric diagnoses in Swedish adults (N=909,699), eight self- and parent-rated psychopathology scales in Swedish adolescents (N=2,069), and sixteen parent-rated psychopathology scales in Swedish children (N=14,589). To compare the predictive validity, we analyzed Swedish male military conscripts (N=414,595, mean age: 18.3 years) with measures on both "g" and "p" (derived from eight psychiatric diagnoses). We then examined their unique associations with three intelligence-related outcomes (annual income, highest education, and university entrance exam scores), and sixteen adverse outcomes (e.g., suicidal behavior, psychotropic medication prescription, and criminality) retrieved from registers (mean age at follow-up = 29.2 years). Results indicated that the magnitudes of "g" and "p" were very similar. Controlling for "p", "g" significantly predicted later education (standardized beta, β=0.38, SE=0.01) and university entrance exam scores (β=0.48, SE=0.01). Controlling for "g", "p" significantly predicted all adverse outcomes (mean β=0.32; range: 0.15 to 0.47). These findings support the notion that psychopathology indicators can be combined into a single score, similar to how intelligence subtests are combined into a general intelligence score. This "p" score might supplement specific diagnoses when formulating a management plan and predicting prognosis.
RADIOFREQUENCY ABLATION USING BARRX FOR THE ENDOSCOPIC TREATMENT OF GASTRIC ANTRAL VASCULAR ECTASIA (GAVE) AND RADIATION PROCTITIS: A SINGLE CENTRE EXPERIENCE
Authors: WD Venon, S Caronna, M Boschini, P Cortegoso Valdivia, L Venezia, GM Saracco, CG De Angelis
Journal: Endoscopy (2020)

Aims Radiofrequency ablation (RFA) is a new endoscopic technique recently introduced to treat gastric antral vascular ectasia (GAVE) and chronic radiation proctitis. Data from literature are limited for samples, treatment schedule and costs. We here assess safety and efficacy of RFA in these patients.
Peptide receptor radionuclide therapy for neuroendocrine tumors in Germany: Initial results of a multiinstitutional cancer registry.
Authors: Dieter Hörsch
Journal: Journal of Clinical Oncology (2012)

e14513 Background: Peptide receptor radionuclide therapy is an effective treatment option for patients with well differentiated somatostatin receptor expressing neuroendocrine tumors. However, published data results mainly from retrospective monocentric studies. Methods: We initiated a multi-institutional, prospective and board reviewed registry for patients treated with Peptide receptor radionuclide therapy in Germany in 2009. Results: In five centers, 297 patients were registered. Primary tumors were mainly derived from pancreas (117/297), small intestine (80/297) whereas 56 were of unknown primary. Most tumors were well differentiated with a median Ki67 proliferation rate of 5% (range 0.9 to 70). Peptide receptor radionuclide therapy was performed using mainly Yttrium-90 and/or Lutetium-177 as radionuclides in 1-8 cycles. Mean overall survival was estimated at 213 months with a follow up between 1 and 230 months after initial diagnosis and 87 months with a follow up between 1 and 92 months after start of Peptide receptor radionuclide therapy. Median overall survival was not yet reached. Subgroup analysis demonstrated that best results were obtained in neuroendocrine tumors with a proliferation rate below 20%. Conclusions: Our results indicate that Peptide receptor radionuclide therapy is an effective treatment well and moderately differentiated neuroendocrine tumors irrespective of previous therapies and should be regarded a one of the primary treatment options for patients with neuroendocrine tumors.
PANCREATIC DUCT STONE CLEARANCE WITH SPY BASKET
Authors: CA Parisinos, HP Martin, T El Menabawey, GJ Webster
Journal: Endoscopy (2020)

A 63 year old man presented with recurrent acute pancreatitis secondary to chronic calcific pancreatitis. There was a 9 mm calcified stone obstructing the duct in the neck of pancreas, with upstream duct dilatation. At an index ERCP stone extraction was unsuccessful.
ENDOTHERAPY IN PATIENTS WITH PRIMARY SCLEROSING CHOLANGITIS: OVER 30 YEARS’ EXPERIENCE
Authors: V Bove, A Tringali, R Landi, I Boskoski, P Familiari, V Perri, G Costamagna
Journal: Endoscopy (2020)

Aims Primary Sclerosing Cholangitis(PSC) is a chronic cholestatic liver disease characterized by inflammation and periductal fibrosis of the intrahepatic and/or extrahepatic bile ducts. Endoscopic dilation of symptomatic dominant biliary strictures is a temporary therapeutic option in these patients frequently candidate to liver transplantation. Our experience over a 30-years period is reported.
How Would You Manage This Patient With Osteoporosis?
Authors: Risa B. Burns, Harold Rosen, Sarah Berry, Gerald W. Smetana
Journal: Annals of Internal Medicine (2018)

Osteoporosis is a skeletal disorder characterized by reduced bone strength that increases the risk for fracture. Approximately 10 million men and women in the United States have osteoporosis, and more than 2 million osteoporosis-related fractures occur annually. In 2016, the American Association of Clinical Endocrinologists issued the “Clinical Practice Guideline for the Diagnosis and Treatment of Postmenopausal Osteoporosis,” and in 2017, the American College of Physicians issued the guideline “Treatment of Low Bone Density or Osteoporosis to Prevent Fracture in Men and Women.” Both guidelines agree that patients diagnosed with osteoporosis should be treated with an antiresorptive agent, such as alendronate, that has been shown to reduce hip and vertebral fractures. However, there is no consensus on how long patients with osteoporosis should be treated and whether bone density should be monitored during and after the treatment period. In this Beyond the Guidelines, 2 experts discuss management of osteoporosis in general and for a specific patient, the role of bone density monitoring during and after a 5-year course of alendronate, and treatment recommendations for a patient whose bone density decreases during or after a 5-year course of alendronate.