tbuckley/cabot-search huggingface dataset:
Control of HIV-1 Infection By Ferroportin Q248H Mutation
Authors: Namita Kumari, Seyed Mehdi Nouraie, Hatajai Lassiter, Asrar Ahmad, Kathryn Anastos, Jason Lazar, Seble Kassaye, Bradley Aouizerat, Audrey French, Stephen Gange, Adaora Adimora, Neale Weitzmann, Margaret Fischl, Mirjam-Colette Kempf, Sergei Nekhai
Journal: Blood (2019)
Dual Effects of Nox2-NADPH Oxidase During Atherosclerotic Plaque Development in Apolipoprotein E-Null Mice
Authors: Courtney P Judkins, Henry Diep, Brad R Broughton, Anja E Mast, Elizabeth U Hooker, Alyson A Miller, Stavros Selemidis, Gregory J Dusting, Christopher G Sobey, Grant R Drummond
Journal: Circulation (2009)
Genetic Analysis in the Tanzania Sickle Surveillance Study (TS3): Modifiers of Sickle Cell Disease and Identification of Hemoglobin Variants
Authors: Luke R. Smart, Emmanuela E. Ambrose, Mwesige Charles, Arielle G. Hernandez, Teresa S. Latham, Adolfine Hokororo, Medard Beyanga, Erasmus Kamugisha, Erius Tebuka, Thad A. Howard, Russell E. Ware
Journal: Blood (2019)
What are the Main Pathogenetic Features of Vascular Cognitive Impairment?
Authors: Jellinger Kurt A
Journal: Alzheimers Disease & Dementia (2017)

The term vascular cognitive impairment designates a heterogenous group of disorders ranging from mild cognitive impairment to full-blown dementia - vascular dementia - resulting from cerebrovascular lesions involving various brain areas. Current clinical criteria show moderate sensitivity (50-56%) and variable specifi city (range 64-98%). The prevalence in autopsy series ranges from 0.03 to 58% (mean 8-15% in Western series, 22-35% in Japan). Major morphological types - multiinfarct and subcortical vascular encephalopathy, strategic infarct dementia, lacunar state, granular atrophy (rare), and ischemic encephalopathy-are caused by atherosclerosis of major cerebral arteries and small vessel disease, resulting from systemic, cardiac and local vascular disease or cerebral amyloid angiopathy.
The ventral lateral parietal cortex in episodic memory: From content to attribution
Authors: Roni Tibon
Journal: Behavioral and Brain Sciences (2019)

Abstract The ventral lateral parietal cortex (VLPC) shows robust activation during episodic retrieval, and is involved in content representation, as well as in the evaluation of memory traces. This suggests that the VLPC has a crucial contribution to the quality of recollection and the subjective experience of remembering, and situates it at the intersection of the core and attribution systems.
Hormonal Therapy or Chemotherapy for Metastatic Prostate Cancer — Playing the Right CARD
Authors: Mario A. Eisenberger, Emmanuel S. Antonarakis
Journal: New England Journal of Medicine (2019)

Since 2004, eight therapeutic agents have received approval from the Food and Drug Administration for the treatment of men with advanced prostate cancer. Four are androgen-signaling–targeted inhibitors that impair androgen-receptor function (abiraterone, enzalutamide, apalutamide, and darolutamide), two are taxane chemotherapies that suppress microtubule dynamics (docetaxel and cabazitaxel), one is a bone-targeted α-emitting radiopharmaceutical agent (radium-223), and one is an autologous cell–based immunotherapy (sipuleucel-T).1 The pivotal trials for these agents generally compared the new therapy with placebo or a non–life-prolonging treatment and were designed primarily to satisfy regulatory requirements for drug approval, thus preventing insights about comparative efficacy or appropriate treatment . . .
Abstract 15797: Data-Driven Trajectories Modeling of On-Treatment Systolic Blood Pressure and Cardiovascular Risks in Sprint and Accord: Similar Pattern in Different Trials
Authors: Xiaodong Zhuang, Lizhen Liao, Yuehua Dong, Xin Xue Liao
Journal: Circulation (2019)

Introduction: Characterizing on-treatment SBP as trajectories provides more dynamic information on treatment effectiveness. However, on-treatment SBP trajectories with long-term follow-up and its i...
The proton-activated ovarian cancer G protein-coupled receptor 1 (OGR1) is responsible for renal calcium loss during acidosis
Authors: Pedro Henrique Imenez Silva, Chahira Katamesh-Benabbas, Kessara Chan, Eva Maria Pastor Arroyo, Thomas Knöpfel, Carla Bettoni, Marie-Gabrielle Ludwig, Jürg A. Gasser, Andrea Brandao-Burch, Timothy R. Arnett, Olivier Bonny, Klaus Seuwen, Carsten Alexander Wagner
Journal: Kidney International (2019)
Global warming threatens human thermoregulation and survival
Authors: Rexford S. Ahima
Journal: Journal of Clinical Investigation (2020)

There is overwhelming evidence showing that human activities have contributed to global warming over the past century.Global warming has a severe impact on food and water supplies, housing and other infrastructure, health, and economic activities.The human body has thermoregulatory mechanisms that adapt to ambient temperature and maintain normal core body temperature for physiological functions.This JCI Viewpoint article discusses how extreme temperatures driven by global warming disrupt normal thermoregulation and imperil human health and survival.
FDG PET/CT Findings of Ectopic Pituitary Adenoma
Authors: Umiko Ishizaki, Koichiro Abe, Kamio Takako, Kenta Masui, Shuji Sakai
Journal: Clinical Nuclear Medicine (2019)

A 72-year-old woman had undergone a right mastectomy for breast cancer 3 years earlier. PET/CT revealed a tumor with bony destruction of the skull base and FDG accumulation (SUVmax, 7.86). MRI showed the well-circumscribed tumor in the sphenoid sinus. The possibility of bone metastasis could not be denied. Tumor removal surgery was performed; the tumor was separate from the normal pituitary gland, and an ACTH-producing ectopic pituitary adenoma was diagnosed pathologically.
miR-107 promotes tumor progression by targeting the let-7 microRNA in mice and humans
Authors: Pai-Sheng Chen, Jen-Liang Su, Shih-Ting Cha, Woan-Yuh Tarn, Ming-Yang Wang, Hsing-Chih Hsu, Ming-Tsan Lin, Chia-Yu Chu, Kuo-Tai Hua, Chiung-Nien Chen, Tsang-Chih Kuo, King-Jen Chang, Michael Hsiao, Yi-Wen Chang, Jin-Shing Chen, Pan-Chyr Yang, Min-Liang Kuo
Journal: Journal of Clinical Investigation (2017)

The authors recently became aware of errors in the assembly of Figure 3A that resulted in incorrect images for the U6 Northern blot for the lung cancer and breast cancer cell lines.
Molecular subgrouping of atypical teratoid/rhabdoid tumors—a reinvestigation and current consensus
Authors: Ben Ho, Pascal D Johann, Yura Grabovska, Mamy Jean De Dieu Andrianteranagna, Fupan Yao, Michael Frühwald, Martin Hasselblatt, Franck Bourdeaut, Daniel Williamson, Annie Huang, Marcel Kool
Journal: Neuro-Oncology (2019)

Atypical teratoid/rhabdoid tumors (ATRTs) are known to exhibit molecular and clinical heterogeneity even though SMARCB1 inactivation is the sole recurrent genetic event present in nearly all cases. Indeed, recent studies demonstrated 3 molecular subgroups of ATRTs that are genetically, epigenetically, and clinically distinct. As these studies included different numbers of tumors, various subgrouping techniques, and naming, an international working group sought to align previous findings and to reach a consensus on nomenclature and clinicopathological significance of ATRT subgroups.We integrated various methods to perform a meta-analysis on published and unpublished DNA methylation and gene expression datasets of ATRTs and associated clinicopathological data.In concordance with previous studies, the analyses identified 3 main molecular subgroups of ATRTs, for which a consensus was reached to name them ATRT-TYR, ATRT-SHH, and ATRT-MYC. The ATRT-SHH subgroup exhibited further heterogeneity, segregating further into 2 subtypes associated with a predominant supratentorial (ATRT-SHH-1) or infratentorial (ATRT-SHH-2) location. For each ATRT subgroup we provide an overview of its main molecular and clinical characteristics, including SMARCB1 alterations and pathway activation.The introduction of a common classification, characterization, and nomenclature of ATRT subgroups will facilitate future research and serve as a common ground for subgrouping patient samples and ATRT models, which will aid in refining subgroup-based therapies for ATRT patients.
Simultaneous Time-of-Flight PET/MR Identifies the Hepatic 90Y-Resin Distribution After Radioembolization
Authors: Chien-Hsin Ting, Ko-Han Lin, Chuang-Hsin Chiu, Rheun-Chuan Lee, Wen-Sheng Huang
Journal: Clinical Nuclear Medicine (2019)

Abstract A 61-year-old woman with multiple hepatic metastases from uterus cervical cancer received 90 Y radioembolization. The simultaneous time-of-flight (TOF) PET/MR clearly identified the untreated tumor parts on the posttherapeutic 90 Y internal pair-production imaging. After another boosted 90 Y injection, the metastatic hepatic tumors were well covered. The follow-up PET/MR revealed tumor shrinkage. The one-stop-shop TOF PET/MR provided useful follow-up information in patients receiving 90 Y radioembolization.
Abstract 15477: Readmission-Free Period and In-Hospital Mortality at the Time of First Readmission in Acute Heart Failure Patients
Authors: Ahmed M Altibi, George Prousi, Mahek Shah, Manyoo Agarwal, Pradhum Ram, Byomesh K Tripathi, Shantanu Patil, Brijesh D Patel
Journal: Circulation (2019)

Introduction: Heart Failure (HF) is the most common cause of hospital readmission in the USA with annual readmission costs of $2 Billion. Historically, readmissions were associated with poor health...
Oral Oncology Parity Laws, Medication Use, and Out-of-Pocket Spending for Patients With Blood Cancers
Authors: Stacie B Dusetzina, Haiden A Huskamp, Shelley A Jazowski, Aaron N Winn, William A Wood, Adam Olszewski, Ethan Basch, Nancy L Keating
Journal: JNCI Journal of the National Cancer Institute (2019)

Abstract Background In this study, we sought to estimate the association between oral oncology parity law adoption and anticancer medication use for patients with chronic myeloid leukemia or multiple myeloma. Methods This was an observational study of administrative claims from 2008 to 2017. Among individuals initiating tyrosine kinase inhibitors (TKIs) for chronic myeloid leukemia or immunomodulatory drugs for multiple myeloma, we compared out-of-pocket spending, adherence, and discontinuation before and after parity among individuals in fully insured plans (subject to parity) vs self-funded plans (exempt from parity) using propensity-score weighted difference-in-differences regression models. Results Among patients initiating TKIs (N = 2082) or immunomodulatory drugs (N = 3326) there were no statistically significant differences in adherence or discontinuation associated with parity. The proportion of patients with initial out-of-pocket payments of $0 increased in fully insured plans after parity from 5.7% to 46.1% for TKIs and from 10.9% to 48.8% for immunomodulatory drugs. Relative to changes in self-funded plans, those in fully insured plans were 4.27 (95% CI = 2.20 to 8.27) times as likely to pay nothing for TKIs and 1.96 (95% CI = 1.40 to 2.73) times as likely to pay nothing for immunomodulatory drugs after parity. Similarly, the proportion paying more than $100 decreased from 30.3% to 24.7% for TKIs and 30.6% to 27.5% for immunomodulatory drugs in fully insured plans after parity. Relative to changes in self-funded plans, those in fully insured plans were 0.74 (95% CI = 0.54 to 1.01) times as likely to pay more than $100 for TKIs and 0.85 (95% CI = 0.68 to 1.06) times as likely to pay more than $100 for immunomodulatory drugs after parity. Conclusions Among patients initiating TKIs or immunomodulatory drugs, parity was not associated with better adherence or less discontinuation of therapy but yielded decreased patient out-of-pocket payments for some patients.
Abstract 12665: Remodeling of Nuclear Ca <sup>2+</sup> Disposition in Atrial Fibrillation Associated Remodeling
Authors: Xiao- Y Qi, Louis Villeneuve, Feng Xiong, Yiguo Sun, Dobromir Dobrev, Stanley Nattel
Journal: Circulation (2015)

Introduction: Atrial fibrillation (AF) induces substantial self-promoting remodeling related to the rapid atrial rate. There is evidence that changes in nuclear Ca 2+ content alter ion channel gene expression and thereby effect electrophysiological changes that increase AF vulnerability and maintenance. However, the ways in which AF affects atrial cardiomyocyte (ACM) nuclear Ca 2+ disposition are unknown. Here, we studied the effects of AF-related remodeling on ACM nuclear structure and Ca 2+ handling. Methods and Results: ACMs were isolated from control (CTL) dogs and dogs subjected to 1 week of AF maintained by atrial tachypacing at 600 bpm (n=7, 6 respectively). We used nuclear imaging with Fluo-5N AM and nucleoplasmic and cytoplasmic calcium transient (CaT) recordings from intact ACMs loaded with Fluo-4 AM. AF significantly decreased the number of nuclear invaginations (NIV) normalized to nuclear envelope (NE) circumference, and increased nuclear length and perimeter in ACMs (Figure A). Diastolic [Ca 2+ ] nuc and [Ca 2+ ] cyto increased in AF vs CTL (Figure B, by 110%*, 89%* respectively, *P&lt;0.05). Nucleoplasmic Ca 2+ transient amplitude decreased significantly with AF, but simultaneously measured cytoplasmic transient amplitude did not change (Figure C). Relaxation time from peak of the Ca 2+ transient to 50% decline (TD 50 ) of nucleoplasmic and cytoplasmic CaTs were significantly prolonged in AF. The addition of a physiological nuclear Ca 2+ transient enhancer, endothelin (200 nM), increased diastolic [Ca 2+ ] nuc and [Ca 2+ ] cyto in both CTL (by 25±6%, 21±6%) and AF (by 40±4%, 31±2 ) ACMs. The IP3 receptor blocker 2-aminoethoxydiphenyl borate (2-APB, 5 μM) abolished endothelin effects on [Ca 2+ ] nuc . Conclusions: AF-related remodeling alters atrial cardiomyocyte nuclear structure and nucleoplasmic [Ca 2+ ] handling. These alterations may play an important role in associated gene-expression changes that produce the AF substrate.
Corrigendum to “A new method for diagnosis of anterior cruciate ligament tear: MRI with maximum flexion of knee in the prone position: A case control study” [Int. J. Surg. 68 (2019) 142–147]
Authors: Burak Gunaydin, Gulcan Gucer Sahin, Abdulkadir Sari, Adnan Kara, Yasar Mahsut Dincel, Mehmet Umit Cetin, Cagatay Tekin, Yavuz Selim Kabukcuoglu
Journal: International Journal of Surgery (2019)
Increased risk of MDS/AML post radiation treatment for breast cancer: Analysis of SEER data 2001-2008.
Authors: Henry G. Kaplan, Judith April Malmgren, Anneclaire DeRoos
Journal: Journal of Clinical Oncology (2012)

6560 Background: Ionizing radiation is a known cause of myeloid leukemia, but it is not known whether therapeutic doses for breast cancer (BC) pose risk. We hypothesized that BC radiation treatment is associated with increased risk of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML)) as seen in a previously conducted institutional cohort study. Methods: We used 2001-2008 Surveillance, Epidemiology and End Results (SEER) database records to identify a cohort of first primary BC patients treated with radiation who were unlikely to be treated with chemotherapy (stage 0 and estrogen receptor positive (ER+) stage I). We identified subsequent MDS/AML diagnoses in the BC cohort, using SEER to query appropriate ICD-O-3 codes. We compared observed MDS/AML rates in the BC cohort to expected rates, estimated for first primary MDS/AML in the entire population, and calculated observed/expected rate ratios with 95% confidence intervals (CI). Results: We estimated an increased overall risk of MDS/AML in the breast cancer cases treated with radiation compared to the general population (RR=4.23, 95% CI 3.41, 5.18). The relative risk was higher for stage I ER+ breast cancer cases &lt;65 years of age (RR=7.75, 95% CI 5.18, 11.05) than for stage 0 cases &lt;65 years of age (RR=3.65, 95% CI 1.57, 7.05). Among women 65 years and older, there was a more modest increased risk, only seen for stage 1 ER+ breast cancer cases (RR=1.52) (table). Conclusions: Our results suggest that radiation treatment for breast cancer is associated with increased risk of MDS/AML. The effect appears to be age-dependent. [Table: see text]
Adding Patient-Reported Outcomes to Medicare’s Oncology Value-Based Payment Model
Authors: Ethan Basch, Lalan Wilfong, Deborah Schrag
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Female Genital Schistosomiasis
Authors: Peter J. Hotez, Dirk Engels, Margaret Gyapong, Camilla Ducker, Mwelecele N. Malecela
Journal: New England Journal of Medicine (2019)

Female genital schistosomiasis is a common complication of Schistosoma haematobium parasitism. Many experts believe that praziquantel for FGS prevention should be added to HPV and HIV preventive measures to promote sexual and reproductive health in African women.
Comparison of Different Upfront Transplant Strategies in Multiple Myeloma - a Large Registry Study from Chronic Malignancies Working Party of EBMT
Authors: Stefan O. Schönland, Simona Iacobelli, Linda Koster, Didier Blaise, Michael Potter, Jan J Cornelissen, Patrice Chevallier, Jiri Mayer, Péter Reményi, John G. Gribben, Ellen Meijer, Ben Carpenter, Matthew P. Collin, Tobias Gedde-Dahl, Victoria Potter, Ram Malladi, Matthias Stelljes, Adrian Bloor, Tulin Tuglular, Florian Weissinger, Meral Beksac, Patrick J Hayden, Ibrahim Yakoub-Agha, Nicolaus Kröger
Journal: Blood (2019)
Extended Focal Imaging Reveals An Improved Gauge of Angiogenic Activity and Highlights the Role of Angiogenesis in Survival and Time to Transformation in Follicular Lymphoma
Authors: Andrew J. Clear, Abigail M. Lee, Kelly J. Morris, Maria Calaminici, Finlay Macdougall, Lindsey K. Goff, T. Andrew Lister, John G. Gribben
Journal: Blood (2008)
Management and control of an outbreak of vaccine-preventable severe pneumococcal disease at a shipyard in Norway
Authors: Jacob Dag Berild, Anneke Steens, Brita Askeland Winje, Tor Erik Danielsen, Jan Håkon Fjeldheim, Helene Daae-Qvale Holmemo, Didrik Frimann Vestrheim
Journal: Journal of Infection (2019)
Corrigendum to “Plasma membrane activatable polymeric nanotheranostics with self-enhanced light-triggered photosensitizer cell influx for photodynamic cancer therapy” [J. Control. Release 255 (2017) 231–241]
Authors: Hao-Ran Jia, Yao-Wen Jiang, Ya-Xuan Zhu, Yan-Hong Li, Hong-Yin Wang, Xiaofeng Han, Zhi-Wu Yu, Ning Gu, Peidang Liu, Zhan Chen, Fu-Gen Wu
Journal: Journal of Controlled Release (2019)
Pharmacotherapy for Insomnia Disorder in Older Adults
Authors: Michael A. Grandner, Michael L. Perlis
Journal: JAMA Network Open (2019)

Russell Rosenberg, PhD; Patricia Murphy, PhD; Gary Zammit, PhD; David Mayleben, PhD; Dinesh Kumar, PhD; Shobha Dhadda, PhD; Gleb Filippov, MD, PhD; Antonia LoPresti, MD; Margaret Moline, PhD
Nonalcoholic Fatty Liver Disease and Fibrosis Associated With Increased Risk of Cardiovascular Events in a Prospective Study
Authors: Francesco Baratta, Daniele Pastori, Francesco Angelico, Andrea Balla, Alessandro Maria Paganini, Nicholas Cocomello, Domenico Ferro, Francesco Violi, Arun J. Sanyal, Maria Del Ben
Journal: Clinical Gastroenterology and Hepatology (2019)
Clinical Significance and Outcomes in Trial of Nabiximols for Treatment of Cannabis Dependence—Reply
Authors: Nicholas Lintzeris, Jan Copeland, Raimondo Bruno
Journal: JAMA Internal Medicine (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
The Deubiquitinase USP38 Promotes NHEJ Repair through Regulation of HDAC1 Activity and Regulates Cancer Cell Response to Genotoxic Insults
Authors: Yongfeng Yang, Chuanzhen Yang, Tingting Li, Shuyu Yu, Tingting Gan, Jiazhi Hu, Jun Cui, Xiaofeng Zheng
Journal: Cancer Research (2019)

Abstract The DNA damage response (DDR) is essential for maintaining genome integrity. Mounting evidence reveals that protein modifications play vital roles in the DDR. Here, we show that USP38 is involved in the DDR by regulating the activity of HDAC1. In response to DNA damage, USP38 interacted with HDAC1 and specifically removed the K63-linked ubiquitin chain promoting the deacetylase activity of HDAC1. As a result, HDAC1 was able to deacetylate H3K56. USP38 deletion resulted in persistent focal accumulation of nonhomologous end joining (NHEJ) factors at DNA damage sites and impaired NHEJ efficiency, causing genome instability and sensitizing cancer cells to genotoxic insults. Knockout of USP38 rendered mice hypersensitive to irradiation and shortened survival. In addition, USP38 was expressed at low levels in certain types of cancers including renal cell carcinoma, indicating dysregulation of USP38 expression contributes to genomic instability and may lead to tumorigenesis. In summary, this study identifies a critical role of USP38 in modulating genome integrity and cancer cell resistance to genotoxic insults by deubiquitinating HDAC1 and regulating its deacetylation activity. Significance: This study demonstrates that USP38 regulates genome stability and mediates cancer cell resistance to DNA-damaging therapy, providing insight into tumorigenesis and implicating USP38 as a potential target for cancer diagnosis.