tbuckley/cabot-search huggingface dataset:
AB1334-HPR BARRIERS AND FACILITATORS TO PHYSICAL ACTIVITY IN JUVENILE IDIOPATHIC ARTHRITIS (JIA): A SCOPING REVIEW
Authors: K. O Donoghue, L. Larkin
Journal: Annals of the Rheumatic Diseases (2020)

Background: Physical activity is an important aspect in the management of JIA (1). However physical activity levels are low in this population (2). Limited research has been conducted to identify definitive barriers and facilitators to physical activity in children and adolescents who have JIA. Objectives: The objective of this scoping review was to identify the common barriers and facilitators to physical activity in JIA. Methods: Original studies, either quantitative or qualitative, including participants with a diagnosis of JIA, who were under 18 years of age were included. Two independent reviewers carried out a search of the literature and full text reviews of papers to determine eligibility for inclusion. The Critical Skills Appraisal Programme (CASP), Appraisal tool for Cross-Sectional Studies (AXIS) and Downs and Black critical appraisal tools were used to assess the quality of the included research articles. Results: Eighteen studies were included in the review. The included studies were of a variety of low, moderate and high quality. The synthesis of the data identified pain to be the most common barrier and the modification of physical activities to the need of the individual to be the most common facilitator to physical activity in JIA. Conclusion: Identifying the most common barriers and facilitators to physical activity allows clinicians to apply better management strategies when treating an individual with JIA. Our findings demonstrate the need for further research in this area to assist increasing physical activity participation for children and adolescents who have JIA. References: [1]Kuntze, G., Nesbitt, C., Whittaker, J.L., Nettel-Aguirre, A., Toomey, C., Esau, S., Doyle-Baker, P.K., Shank, J., Brooks, J., Benseler, S., Emery, C.A. (2018) ‘Exercise Therapy in Juvenile Idiopathic Arthritis: A Systematic Review and Meta-Analysis’, Archives of Physical Medicine and Rehabilitation , 99(1), 178-193 [2]Bos, G.J.F.J., Lelieveld, O.T.H.M., Armbrust, W., Sauer, P.J.J., Geertzen, J.H.B., Dijkstra, P.U. (2016) ‘Physical activity in children with Juvenile Idiopathic Arthritis compared to controls’ , Pediatric Rheumatology , 14(1), 42. Disclosure of Interests: None declared
Cardiac Troponin I Is an Independent Predictor for Mortality in Hospitalized Patients With COVID-19
Authors: Shao-Fang Nie, Miao Yu, Tian Xie, Fen Yang, Hong-Bo Wang, Zhao-Hui Wang, Ming Li, Xing-Li Gao, Bing-Jie Lv, Shi-Jia Wang, Xiao-Bo Zhang, Shao-Lin He, Zhi-Hua Qiu, Yu-Hua Liao, Zi-Hua Zhou, Xiang Cheng
Journal: Circulation (2020)

heart injuries ◼ hospital mortality ◼ patient outcome assessment ◼ troponin I S ince December 2019, coronavirus disease 2019 (COVID-19) has caused a global pandemic with thousands of pneumonia-related deaths. 1 Recently, Wang et al 2 reported the existence of myocardial injury in 7.2% of all patients with COVID-19 and in 22.2% of patients admitted to the intensive care unit versus only 2.0% patients not treated in the intensive care unit.Thus, we hypothesized that cardiac troponin I (cTNI), an established biomarker of cardiac injury, may be a clinical predictor of outcomes for patients with COVID-19.Patients with laboratory-confirmed COVID-19 admitted to Union Hospital (West Campus), Huazhong University of Science and Technology from January 12 to March 12, 2020, were enrolled, and the final date of follow-up was March 20, 2020.This study was
Extramediastinal Lesion in Patients with Primary Mediastinal Large B-Cell Lymphoma
Authors: Yana K. Mangasarova, Aminat U. Magomedova, Alla M. Kovrigina, Anna E. Misyurina, Ekaterina S. Nesterova, Sergey K. Kravchenko, Valery G. Savchenko
Journal: Blood (2017)
Genetically modified immune cells targeting tumor antigens
Authors: Mansour Poorebrahim, Mohammad Foad Abazari, Solmaz Sadeghi, Reza Mahmoudi, Asma Kheirollahi, Hassan Askari, Stina L. Wickström, Vahdat Poortahmasebi, Andreas Lundqvist, Rolf Kiessling, Angel Cid-Arregui
Journal: Pharmacology & Therapeutics (2020)

Immunotherapy approaches consisting of genetically modified immune cells have become a promising platform for cancer treatment. Such 'living' therapies targeting tumor antigens have shown success in many cancer patients in the form of durable responses in a growing number of clinical studies. Besides, a large number of ongoing studies have been designed to introduce reliable methods for identification of tumor antigens. In addition, technical and biotechnological developments are being applied to the generation and expansion of genetically modified immune cells. In this review, we summarize and discuss the latest progress and current challenges in the tumor antigen landscape and in the generation of genetically modified immune cells in view of their clinical efficacy, either as monotherapy or combinational therapy.
Recommendations for altitude training programming to preserve athletes’ health after the COVID-19 pandemic
Authors: Giorgio Manferdelli, David John Bishop, Martino V Franchi, Fabio Sarto, Olivier Girard, Simone Porcelli
Journal: British Journal of Sports Medicine (2020)

The pharmacological targeting of the <i>α</i>7 nicotinic acetylcholine receptor (<i>α</i>7) is a promising strategy in the development of new drugs for neurologic diseases. Because <i>α</i>7 receptors regulate cellular calcium, we investigated how the prototypical type II–positive allosteric modulator PNU120596 affects <i>α</i>7-mediated calcium signaling. Live imaging experiments show that PNU120596 augments ryanodine receptor-driven calcium-induced calcium release (CICR), inositol-induced calcium release (IICR), and phospholipase C activation by the <i>α</i>7 receptor. Both influx of calcium through the <i>α</i>7 nicotinic acetylcholine receptor (nAChR) channel as well as the binding of intracellular G proteins were involved in the effect of PNU120596 on intracellular calcium. This is evidenced by the findings that chelation of extracellular calcium, expression of <i>α</i>7<sub>D44A</sub> or <i>α</i>7<sub>345–348A</sub> mutant subunits, or blockade of calcium store release compromised the ability of PNU120596 to increase intracellular calcium transients generated by <i>α</i>7 ligand activation. Spatiotemporal stochastic modeling of calcium transient responses corroborates these results and indicates that <i>α</i>7 receptor activation enables calcium microdomains locally and to lesser extent in the distant cytosol. From the model, allosteric modulation of the receptor activates CICR locally via ryanodine receptors and augments IICR through enhanced calcium influx due to prolonged <i>α</i>7 nAChR opening. These findings provide a new mechanistic framework for understanding the effect of <i>α</i>7 receptor allosteric modulation on both local and global calcium dynamics.
Abstract 16279: Diagnosis of Cardiogenic Shock Without the Use of a Pulmonary Artery Catheter
Authors: Amir Najafi, Kambiz Ghafourian, Andre Paixao, Mohamed Aljaabari, Daniel Canos, Federico Asch, Julio Panza, Howard A Cooper
Journal: Circulation (2013)

Background: The diagnosis of cardiogenic shock (CS) traditionally requires invasive hemodynamic assessment with pulmonary artery catheterization (PAC). We developed and validated a set of noninvasi...
Oxygen-Enhanced Optoacoustic Tomography Reveals the Effectiveness of Targeting Heme and Oxidative Phosphorylation at Normalizing Tumor Vascular Oxygenation
Authors: Poorva Ghosh, Yihang Guo, Adnin Ashrafi, Jingyu Chen, Sanchareeka Dey, Shigen Zhong, Jie Liu, James Campbell, Purna Chaitanya Konduri, Jeni Gerberich, Massoud Garrossian, Ralph P. Mason, Li Zhang, Li Liu
Journal: Cancer Research (2020)

Abstract Multispectral optoacoustic tomography (MSOT) is an emerging noninvasive imaging modality that can detect real-time dynamic information about the tumor microenvironment in humans and animals. Oxygen enhanced (OE)-MSOT can monitor tumor vasculature and oxygenation during disease development or therapy. Here, we used MSOT and OE-MSOT to examine in mice the response of human non–small cell lung cancer (NSCLC) xenografts to a new class of antitumor drugs, heme-targeting agents heme-sequestering peptide 2 (HSP2) and cyclopamine tartrate (CycT). HSP2 inhibits heme uptake, while CycT inhibits heme synthesis in NSCLC cells, where heme is essential for ATP generation via oxidative phosphorylation. HSP2 and CycT can inhibit ATP generation and thereby suppress NSCLC cell tumorigenic functions. MSOT showed that treatment of NSCLC tumors with HSP2 or CycT reduced total hemoglobin, increased oxygen saturation, and enhanced the amplitude of response to oxygen gas breathing challenge. HSP2 and CycT normalized tumor vasculature and improved tumor oxygenation, where levels of several hypoxia markers in NSCLC tumors were reduced by treatment with HSP2 or CycT. Furthermore, treatment with HSP2 or CycT reduced levels of angiogenic factor VEGFA, its receptor VEGFR1, and vascular marker CD34. Together, our data show that heme-targeting drugs HSP2 and CycT elicit multiple tumor-suppressing functions, such as inhibiting angiogenic function, normalizing tumor vasculature, alleviating tumor hypoxia, and inhibiting oxygen consumption and ATP generation. Significance: Heme-targeting agents HSP2 and CycT effectively normalize tumor vasculature and alleviate tumor hypoxia, raising the possibility of their combination with chemo-, radio-, and immunotherapies to improve antitumor efficacy. See related commentary by Tomaszewski, p. 3461
SAT0327 SEXUAL DYSFUNCTION IN FEMALE SCLERODERMA PATIENTS AND ITS CORRELATION WITH VASCULAR INVOLVEMENT
Authors: Z. Khodamoradi, M. Nazarinia, E. Esmaeilzadeh
Journal: Annals of the Rheumatic Diseases (2020)

Background: Systemic Sclerosis (Scleroderma, SSc) is an autoimmune disorder characterized by multi-organ dysfunction, which ultimately leads to multiple clinical and psychological complications. Among various complications of scleroderma, sexual dysfunction can be named as a major issue in both male and female patients, which has great impact on quality of life of the patients. Objectives: Investigating the sexual dysfunction in scleroderma patients and its relation to their vascular involvements. Methods: A case control study was done on 80 married female scleroderma patients with age between 20-60 years old. Eighty normal individuals adjusted for age, place of living and socioeconomic status were also recruited. Sexual performance in both groups was assessed using FSFI standardized questionnaire, which evaluated it in 6 domains of desire, arousal, lubrication, orgasm, satisfaction, and pain. Micro and macro-vascular involvements of the patients were also determined using Raynaud Condition Score, Echocardiography, physical exam for assessing their digital ulcers and reviewing their medical records for presence of past or present history of renal crisis and thromboembolic events. Results: The total score of FSFI in the case group was significantly lower compared to control one (16.68 ± 6.35, 19.69 ± 6.01, P-value &lt;0.001). The score was significantly lower in all domains of sexual dysfunction except for pain and lubrication. Moreover, the mean score of FSFI was also found to be significantly lower in limited form of the disease compared to diffuse one (14.6 ± 6.9, 18.1 ± 5.5, P-value 0.01). No significant association was found between vascular complications and sexual impairment of the scleroderma patients. Conclusion: This study can be named as the first survey investigating the sexual dysfunction in Iranian female scleroderma patients and assessing its relation with vascular complication of the disease. Thus, it can be a guide for future studies on sexual dysfunction especially in societies with cultural limitations in discussing this issue. References: [1]Bruni C, Raja J, Denton CP, Matucci-Cerinic M. The clinical relevance of sexual dysfunction in systemic sclerosis. Autoimmun Rev 2015; 14(12):1111-5. doi: 10.1016/j.autrev.2015.07.016. [2]Puchner R, Sautner J, Gruber J, Bragagna E, Trenkler A, Lang G . et al . High Burden of Sexual Dysfunction in Female Patients with Rheumatoid Arthritis: Results of a Cross-sectional Study. J Rheumatol 2019; 46(1):19-26. doi: 10.3899/jrheum.171287. [3]Lin MC, Lu MC, Livneh H, Lai NS, Guo HR, Tsai TY. Factors associated with sexual dysfunction in Taiwanese females with rheumatoid arthritis. BMC Womens Health 2017; 17(1):12. doi: 10.1186/s12905-017-0363-5. [4]Frikha F, Masmoudi J, Saidi N, Bahloul Z. Sexual dysfunction in married women with Systemic Sclerosis. Pan Afr Med J 2014; 17:82. doi: 10.11604/pamj.2014.17.82.3833. Disclosure of Interests: None declared
MRP7/ABCC10 expression is a predictive biomarker for the resistance to paclitaxel in non-small-cell lung cancer
Authors: Takehiro Uemura, Hiroaki Ozasa, Tetsuya Oguri, Yuji Bessho, Mikinori Miyazaki, Ken Maeno, Hiroyoshi Maeda, Shigeki Sato, Ryuzo Ueda
Journal: Cancer Research (2008)

3240  We used the paclitaxel (TAX)-resistant human small-cell lung cancer subline PC-6/TAX1-1, selected from PC-6 cells by TAX, to test whether MRP7/ABCC10 (ABCC10) confers TAX resistance. We found that gene expression of both ABCB1/MDR1 (ABCB1) and ABCC10 was higher in PC-6/TAX1-1 cells than in PC-6 cells. The expression levels of ABCC10 showed a significant inverse correlation with TAX sensitivity (r=0.574, P
Transoesophageal endoscopic removal of a benign mediastinal tumour: a new field for endotherapy?
Authors: Pingting Gao, Quanlin Li, Jianwei Hu, Jiaxin Xu, Shengli Lin, Mingyan Cai, Lili Ma, Weifeng Chen, Yiqun Zhang, Shi-yao Chen, Yunshi Zhong, Liqing Yao, Pinghong Zhou
Journal: Gut (2020)

The approach to paraoesophageal structures and lesions via the oesophagus was initiated by the introduction of peroral endoscopic myotomy (POEM), followed by peroral endoscopic removal of tumours within the muscular layer. We now report a case which suggests that the next step, that is, to remove paraoesophageal tumours not related to the oesophageal wall, would also be possible. This is the case of a 66-year-old male patient with a 4.0×2.0×1.5 cm benign schwannoma from the recurrent laryngeal nerve bulging into the proximal oesophagus, which we removed via a POEM tunnel. The postoperative course was uneventful. Further controlled studies have to show which lesions may be suitable for this expanded approach and also confirm the safety and feasibility of this technique which can be regarded as much less invasive than operative minimal invasive alternatives.

Due to the complicated anatomy of the mediastinum, mediastinal masses represent a heterogeneous group of tumours.1 2 Characteristic location of the mass establishes a useful differential diagnosis that aids in planning the diagnostic evaluation. Video-assisted thoracoscopic surgery and conventional open surgery are the currently available treatments for these patients with benign lesions in whom removal is considered to be indicated, also for clarification of the diagnosis.3–5 Traditional surgical approach can be associated with substantial trauma, slower recovery, higher complication rate and decreased postoperative quality of life.

To overcome these disadvantages, we report on a novel technique, transoesophageal endoscopic surgery, for treating mediastinal tumours. This technique takes advantage of the submucosal tunnelling technique popularised by natural orifice translumenal endoscopic surgery (NOTES). NOTES stimulated with the development of POEM and submucosal tunnelling endoscopic resection (STER), the submucosal or ‘third space’ endoscopy combining minimal invasive surgery and endoscopy. Here we present a rare case of schwannoma originated from the recurrent laryngeal nerve, which we removed via transoesophageal endoscopic surgery …
COVID-19 in patients with rheumatological diseases treated with anti-TNF
Authors: Carlos Antunes Brito, José Gerardo Paiva, Fernando Nunes Pimentel, Rosinete Santos Guimarães, Mariana Ribeiro Moreira
Journal: Annals of the Rheumatic Diseases (2020)

Culture-independent and culture-dependent methods were used to determine the persistence of <i>Hanseniaspora uvarum, Candida</i> sp. EJ1, and <i>Saccharomyces cerevisiae</i> populations within wine fermentations treated with inhibitory levels of sulfur dioxide. Upon addition, SO<sub>2</sub> completely inhibited growth of <i>Hanseniaspora</i> and <i>Candida</i> populations on enrichment media; however, PCR and RT-PCR signatures of each species persisted, in some cases, throughout the complete fermentation (as long as 20 days). PCR-DGGE and RT-PCR-DGGE profiles of yeasts present in the fermentations also indicated persistence of <i>Hanseniaspora</i> and <i>Candida</i> populations after their respective plating populations disappeared. This study demonstrates that molecular signatures of non-<i>Saccharomyces</i> yeasts can remain in wine fermentations treated with SO<sub>2</sub> long after those populations become nonculturable.
Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities
Authors: Karen D. Davis, Nima Aghaeepour, Andrew H. Ahn, Martin S. Angst, David Borsook, Ashley Brenton, Michael E. Burczynski, Christopher Crean, Robert Edwards, Brice Gaudilliere, Georgene W. Hergenroeder, Michael J. Iadarola, Smriti Iyengar, Yunyun Jiang, Jiang-Ti Kong, Sean Mackey, Carl Y. Saab, Christine N. Sang, Joachim Scholz, Marta Segerdahl, Irene Tracey, Christin Veasley, Jing Wang, Tor D. Wager, Ajay D. Wasan, Mary Ann Pelleymounter
Journal: Nature Reviews Neurology (2020)

Pain medication plays an important role in the treatment of acute and chronic pain conditions, but some drugs, opioids in particular, have been overprescribed or prescribed without adequate safeguards, leading to an alarming rise in medication-related overdose deaths. The NIH Helping to End Addiction Long-term (HEAL) Initiative is a trans-agency effort to provide scientific solutions to stem the opioid crisis. One component of the initiative is to support biomarker discovery and rigorous validation in collaboration with industry leaders to accelerate high-quality clinical research into neurotherapeutics and pain. The use of objective biomarkers and clinical trial end points throughout the drug discovery and development process is crucial to help define pathophysiological subsets of pain, evaluate target engagement of new drugs and predict the analgesic efficacy of new drugs. In 2018, the NIH-led Discovery and Validation of Biomarkers to Develop Non-Addictive Therapeutics for Pain workshop convened scientific leaders from academia, industry, government and patient advocacy groups to discuss progress, challenges, gaps and ideas to facilitate the development of biomarkers and end points for pain. The outcomes of this workshop are outlined in this Consensus Statement. In 2018, the Discovery and Validation of Biomarkers to Develop Non-Addictive Therapeutics for Pain workshop convened to discuss strategies to facilitate the development of biomarkers and end points for pain. The outcomes of this workshop are outlined in this Consensus Statement.
Abstract P358: Preventive Program for the Gradual Reduction of Salt Consumption in Italy
Authors: Chiara Donfrancesco, Daniela Galeone, Pasquale Strazzullo, Cinzia Lo Noce, Renato Ippolito, Ornella Russo, Luigi Palmieri, Simona Giampaoli
Journal: Circulation (2013)

Background: Strategies aiming at reducing dietary sodium are being implemented in many countries based on robust evidence-based knowledge supporting their beneficial effects and their cost-effectiv...
Weight Loss Maintenance in Rural Populations in the United States
Authors: Lu Hu, Collin Popp, Mary Ann Sevick
Journal: JAMA Network Open (2020)

Michael G. Perri, PhD; Meena N. Shankar, MS, RD; Michael J. Daniels, ScD; Patricia E. Durning, PhD; Kathryn M. Ross, PhD, MPH; Marian C. Limacher, MD; David M. Janicke, PhD; A. Daniel Martin, PhD; Kumaresh Dhara, PhD; Linda B. Bobroff, PhD; Tiffany A. Radcliff, PhD; Christie A. Befort, PhD
What It Means to Age With HIV Infection
Authors: Lauren F. Collins, Wendy S. Armstrong
Journal: JAMA Network Open (2020)

Julia L. Marcus, PhD, MPH; Wendy A. Leyden, MPH; Stacey E. Alexeeff, PhD; Alexandra N. Anderson, MPH; Rulin C. Hechter, PhD; Haihong Hu, MPH; Jennifer O. Lam, PhD; William J. Towner, MD; Qing Yuan, MPH; Michael A. Horberg, MD; Michael J. Silverberg, PhD
Distinguishing between direct and indirect consequences of covid-19
Authors: Jonine D Figueroa, Paul M Brennan, Evropi Theodoratou, Michael T C Poon, Karin Purshouse, Farhat V N Din, Kai Jin, Ines Mesa-Eguiagaray, Malcolm G Dunlop, Peter S Hall, David Cameron, Sarah H Wild, Cathie L M Sudlow
Journal: BMJ (2020)

Conservation planning is the primary tool the USDA Natural Resources Conservation Service (NRCS) uses to help farmers manage and protect the nation’s soil, water, air, plant, animal, energy, and human natural resources on privately owned lands. While research studies have investigated a multitude of factors that could possibly influence farmer adoption of conservation practices, no recent research exists examining the relationship between having an NRCS conservation plan and the likelihood of applying conservation practices on the ground. This is surprising given that conservation planning is considered to be the foundation for USDA’s technical and financial assistance to agricultural landowners, and recently both the updated NRCS Strategic Plan and the National Conservation Planning Partnership emphasized the need to enhance and expand conservation planning. In this study we analyzed data from 792 respondents of the 2015 and 2016 collection periods of a panel survey of Iowa farmers to examine the relationship between having an NRCS conservation plan and farmers’ implementation of 10 soil and water conservation practices in four categories: (1) soil health, (2) nitrogen (N) management, (3) structural practices, and (4) cropland converted to perennial crops. The results indicate that farmers who reported having an NRCS conservation plan are significantly more likely to have implemented two conservation practices: no-till and terraces. In addition, there was a significant relationship between the number of times a farmer visited a USDA Service Center for conservation and the likelihood they implemented 5 of the 10 selected practices, particularly in the soil health and structural practice categories. These results suggest that it is not the plan itself, but rather the sustained interaction with natural resource professionals, that makes a difference in the use of conservation practices. Implications of the study results for NRCS conservation planning moving forward in the future are discussed.
Safety and immunogenicity of a mosquito saliva peptide-based vaccine: a randomised, placebo-controlled, double-blind, phase 1 trial
Authors: Jessica E Manning, Fabiano Oliveira, Iliano V Coutinho-Abreu, Samantha Herbert, Claudio Meneses, Shaden Kamhawi, Holly Ann Baus, Alison Han, Lindsay Czajkowski, Luz Angela Rosas, Adriana Cervantes-Medina, Rani Athota, Susan Reed, Allyson Mateja, Sally Hunsberger, Emma James, Olga Pleguezuelos, Gregory Stoloff, Jesus G Valenzuela, Matthew J Memoli
Journal: The Lancet (2020)