SAT0200 RISK FACTORS FOR ADVERSE PREGNANCY OUTCOMES IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS
Authors: C. Cetin, T. Saraç-Sivrikoz, M. Ateş-Tikiz, E. S. Torun, A. Ersoy, Y. Yalçinkaya, A. Gul, M. Inanc, M. L. Ocal, İ. Kalelioğlu, B. Artim-Esen
Journal: Annals of the Rheumatic Diseases (2020)

Background: Pregnancies of patients with systemic lupus erythematosus (SLE) can be risky both for the mother and the fetus because of disease activity and pregnancy complications. 1 Objectives: In this study, we evaluated the risk factors related to adverse pregnancy outcomes (APO) in our pregnant SLE cohort who were followed up by both Rheumatology and Obstetrics and Gynecology departments at our university. Methods: 168 pregnancy data were analyzed from 136 patients who fulfilled ACR classification criteria for SLE. The course of pregnancies were monitored and fetal/neonatal outcomes were recorded. Unexplained fetal death after 12 weeks of gestation, neonatal death, preterm birth due to preeclampsia, eclampsia or HELLP and birth of small for gestational age (SGA) infant were defined as APO. Cumulative clinical, laboratory and serological findings, disease activity (SLEDAI-2K) and damage (SLICC/ACR), and conventional risk factors were compared between APO(+) and APO(-) groups. Results: The comparison of demographics, conventional risk factors and disease characteristics in APO(+) and APO(-) groups are summarized in Table-1. In APO(+) pregnancies, the duration of disease was longer (p &lt;0.05) and the frequency of chronic hypertension was higher (p &lt;0.05) compared to APO(-) pregnancies. Renal and neuropsychiatric (NP) involvement, thrombocytopenia, antiphospholipid syndrome (APS), lupus anticoagulant and anti-cardiolipin IgM positivity were significantly higher in APO(+) group. Mean SLEDAI-2K scores of three trimesters and postpartum 6 months were higher in APO(+) patients compared to APO(-) patients (2.2 ± 3.6 vs 1.2 ± 2.04, p &lt;0.05; 4.9 ± 6.03 vs 2.7 ± 5.01, p = 0.02, respectively). Percentage of patients with damage at the beginning of pregnancy and the mean SLICC damage score were significantly higher in APO(+) group compared to APO(-) group (1.8 ± 2.1 vs 0.8 ± 1.3, p &lt;0.05). In APO(+) group, damage was significantly higher in neuropsychiatric, renal and cardiovascular and locomotor systems (p &lt;0.05). Conclusion: Although an important proportion of SLE pregnancies result in live birth, active disease, especially renal and NP involvement, and presence of damage at the beginning of pregnancy increase the risk of maternal and fetal complications. Furthermore, the presence of APS or antiphospholipid antibody positivity are important risk factors for obstetric complications. In conclusion, pregnancy should be allowed after controlling the disease activity and patients should be closely monitored in coordination with Obstetrics and Gynecology clinics. In case of presence of damage, both the patient and the physician should be aware of a possible adverse pregnancy outcome. References: [1] Ann Intern Med. 2015 August 4; 163(3): 153–163. doi:10.7326/M14-2235. Table 1. Demographic data of APO (+) and APO (-) groups, comparison of conventional risk factors, cumulative clinical, serological and laboratory features APO (-) (n=111 ) APO (+ ) (n=57 ) p Age 35.1±6.7 34.9±5.9 NS Age at conception 30.6±5.6 28.9±4.2 NS Disease duration (months ) 141.6±70 166.9±87.9 &lt;0.05 Chronic hypertension, n (% ) 6 (7) 11 (19.6) &lt;0.05 Photosensitivity, n (% ) 86 (77.5) 43 (75.4) NS Malar rash, n (% ) 66 (59.5) 38 (66.7) NS Oral ulcer, n (% ) 11 (9,9) 6 (10.5) NS Arthritis, n (% ) 77 (59.4) 42 (73.7) NS Serositis, n (% ) 17 (15.3) 13 (22.8) NS Renal, n (% ) 39 (35.1) 30 (52.6) &lt;0.05 Hematologic, n (% ) 78 (70.3) 40 (70.2) NS Thrombocytopenia, n (% ) 37 (33.3) 30 (52.6) &lt;0.05 AIHA, n (% ) 16 (14.4) 14 (24.6) NS Neurologic, n (% ) 7 (6.3) 9 (15.8) &lt;0.05 Anti-cardiolipin IgG, n(% ) 28 (25.2) 18 (32.1) NS Anti-cardiolipin IgM, n (% ) 18 (16.2) 18 (32.1) &lt;0.05 Lupus anticoagulant, n (% ) 26 (23.4) 28 (49.1) &lt;0.001 Antiphospholipid syndrome, n (% ) 28 (25.2) 30 (52.6) &lt;0.001 (NS=not significant, APO=adverse pregnancy outcome, AIHA=autoimmune hemolytic anemia) Disclosure of Interests: : None declared