TREATMENT OF ANGINA PECTORIS WITH PROPYLTHIOURACIL
Authors: L WAITZKIN
Journal: Annals of Internal Medicine (1951)

Article1 May 1951TREATMENT OF ANGINA PECTORIS WITH PROPYLTHIOURACILLEO WAITZKIN, M.D.LEO WAITZKIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-34-5-1107 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTotal thyroidectomy in the treatment of angina pectoris, first performed in 1933 by Blumgart, Levine and Berlin,1was employed over a period of years until the lack of sufficiently favorable results led to virtual abandonment of the procedure. Not only was there a fairly serious operative risk but, if the patient's angina was not ameliorated, he was then left with an additional disorder, myxedema. Nevertheless, a review of the literature concerning total thyroidectomy in the treatment of angina indicates that some patients obtained considerable relief following operation. It must be remembered, of course, that the natural course of angina is...Bibliography1. BlumgartLevineBerlin HLSADD: Congestive heart failure and angina pectoris: the therapeutic effect of thyroidectomy on patients without clinical or pathologic evidence of thyroid toxicity, Arch. Int. Med. 51: 866, 1933. CrossrefGoogle Scholar2. Raab W: Thiouracil treatment of angina pectoris, J. A. M. A. 128: 249, 1945. CrossrefGoogle Scholar3. Ben-Asher S: Further observations on the treatment of the anginal syndrome with thiouracil, Am. Heart J. 33: 499, 1947. CrossrefGoogle Scholar4. DiPalmaMaGovern JRJJ: Disadvantages of thiouracil treatment of angina pectoris, Am. Heart J. 32: 494, 1946. CrossrefMedlineGoogle Scholar5. FriskLindgren ARI: Methylthiouracil in the treatment of congestive heart failure and angina pectoris. Results of prolonged treatment, Acta med. Scandinav. 132: 1948. Google Scholar6. HawkOserSummerson PBBLWH: Practical physiological chemistry, ed. 12, 1947, Blakiston Co., Philadelphia, p. 531. Google Scholar7. RiggsMan DSEB: A permanganate acid ashing micromethod for iodine determinations. I. Values in blood of normal subjects, J. Biol. Chem. 134: 193, 1940. Man, E. B., Smernow, A. E., Gildea, E. F., and Peters, J. P.: Serum iodine fractions in hyperthyroidism, J. Clin. Investigation 21: 773, 1942. CrossrefGoogle Scholar8. Master AM: Two-step test of myocardial function, Am. Heart J. 10: 495, 1935. CrossrefGoogle Scholar9. AstwoodBissell EBA: Effect of thiouracil on the iodine content of the thyroid gland, Endocrinology 34: 282, 1944. CrossrefGoogle Scholar10. WinklerRiggsMan AWDSEB: Serum iodine in hypothyroidism before and during thyroid therapy, J. Clin. Investigation 24: 732, 1945. CrossrefMedlineGoogle Scholar11. RiggsManWinkler DSEBAW: Serum iodine of euthyroid subjects treated with desiccated thyroid, J. Clin. Investigation 24: 722, 1945. CrossrefMedlineGoogle Scholar12. EppingerLevine ECSA: Effects of total thyroidectomy on the response to adrenalin, Proc. Soc. Exper. Biol. and Med. 31: 485, 1933-1934. CrossrefGoogle Scholar13. SawyerBrown MEMG: The effect of thyroidectomy and thyroxine on the response of the denervated heart to injected and secreted adrenine, Am. J. Physiol. 110: 620, 1935. CrossrefGoogle Scholar14. LeblondHoff CPHE: Comparison of cardiac and metabolic action of thyroxine, thyroxine derivatives, and dinitrophenol in thyroidectomized rats, Am. J. Physiol. 141: 32, 1944. CrossrefGoogle Scholar15. RisemanGilliganBlumgart JEDRHL: Treatment of congestive heart failure and angina pectoris by total ablation of the normal thyroid gland. XVI. The sensitivity of man to epinephrine injected intravenously before and after total thyroidectomy, Arch. Int. Med. 56: 38, 1935. CrossrefGoogle Scholar16. HollanderMandelbaum GH: The treatment of angina pectoris with propylthiouracil, Ann. Int. Med. 28: 1150-1156, 1948. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication September 13, 1949.From the Medical Service, Cushing Veterans Administration Hospital, Framingham, Massachusetts.Published with the permission of the Chief Medical Director, Veterans Administration, who assumes no responsibility for the opinions expressed or the conclusions drawn by the author. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChoice of Drugs in Angina PectorisDie Coronarerkrankungen. Coronarinsuffizienz, Angina pectoris und HerzinfarktVergleichende Untersuchungen über das Ökonomieprinzip in Arbeit und Leistung des trainierten KreislaufsTreatment of Angina Pectoris 1 May 1951Volume 34, Issue 5Page: 1107-1125KeywordsAnginaMedical servicesThyroidectomy ePublished: 1 December 2008 Issue Published: 1 May 1951 PDF downloadLoading ...