tbuckley/cabot-search huggingface dataset:
Call to action: a collaborative framework to better support female rugby league players
Authors: Cloe Cummins, Jaede Melinz, Doug King, Colin Sanctuary, Aron Murphy
Journal: British Journal of Sports Medicine (2020)

Women’s sports have seen a substantial increase in participation numbers and in their professionalism. There was a 29% increase in the number of Australian women who played rugby league in 20181 and there have been increased competition pathways for women in both Australia (ie, National Rugby League Women’s (NRLW) premiership) and England (ie, Women’s Super League (WSL)).

Although female sporting teams and leagues struggle with participation, financial investment and spectatorship (ie, sociological factors),2 both the NRLW and WSL have major naming right sponsors. The Australian NRLW and State of Origin matches and the WSL grand final are also broadcast live on television.

There is a paucity of sports science, clinical and medical literature on female rugby league players (n=8 articles; Scopus, July 2019). We attribute this to factors such as, participation numbers, limited years of professional women’s rugby league (ie, 2 years in Australia and 3 years in England) and a number of complex sociological factors. Much of the published research is outdated. Indeed the available injury surveillance research3 is over 10 years old and the types and rates of …
THEMIS-SHP1 Recruitment by 4-1BB Tunes LCK-Mediated Priming of Chimeric Antigen Receptor-Redirected T Cells
Authors: Chuang Sun, Peishun Shou, Hongwei Du, Koichi Hirabayashi, Yuhui Chen, Laura E. Herring, Sarah Ahn, Yang Xu, Kyogo Suzuki, Guangming Li, Ourania Tsahouridis, Lishan Su, Barbara Savoldo, Gianpietro Dotti
Journal: Cancer Cell (2020)
Total enteroscopy by antegrade motorized spiral enteroscopy under conscious sedation for acute overt obscure gastrointestinal bleeding
Authors: Raymond S. Y. Tang, Marc T. L. Wong, Jimmy C. T. Lai, Philip W. Y. Chiu
Journal: Endoscopy (2020)

In patients requiring deep enteroscopy, balloon overtube-assisted enteroscopy and spiral overtube-assisted enteroscopy are generally the procedures of choice, but each has its own strengths and limitations in terms of total enteroscopy rate and procedure time [1]. Recently, a novel motorized spiral enteroscope (MSE; Olympus, Tokyo, Japan) equipped with a short motor-driven spiral overtube has become available ([Fig. 1]) [2] [3] [4] [5]. To date, the reported total enteroscopies, whether by antegrade approach alone or combined antegrade and retrograde approaches, have been performed with the patient under general anesthesia or deep sedation [5]. To the best of our knowledge, we here report the first case of total enteroscopy by antegrade MSE being performed for overt obscure gastrointestinal (GI) bleeding in a patient under conscious sedation.
Measles as Metaphor—What Resurgence Means for the Future of Immunization
Authors: Howard K. Koh, Bruce G. Gellin
Journal: JAMA (2020)

S. Cassandra Pingali, MPH, MS; Paul L. Delamater, PhD; Alison M. Buttenheim, MBA, PhD; Daniel A. Salmon, PhD; Nicola P. Klein, MD, PhD; Saad B. Omer, MBBS, MPH, PhD
Individual-patient prediction of meningioma malignancy and survival using the Surveillance, Epidemiology, and End Results database
Authors: Jeremy T. Moreau, Todd C. Hankinson, Sylvain Baillet, Roy W. R. Dudley
Journal: npj Digital Medicine (2020)

Meningiomas are known to have relatively lower aggressiveness and better outcomes than other central nervous system (CNS) tumors. However, there is considerable overlap between clinical and radiological features characterizing benign, atypical, and malignant tumors. In this study, we developed methods and a practical app designed to assist with the diagnosis and prognosis of meningiomas. Statistical learning models were trained and validated on 62,844 patients from the Surveillance, Epidemiology, and End Results database. We used balanced logistic regression-random forest ensemble classifiers and proportional hazards models to learn multivariate patterns of association between malignancy, survival, and a series of basic clinical variables-such as tumor size, location, and surgical procedure. We demonstrate that our models are capable of predicting meaningful individual-specific clinical outcome variables and show good generalizability across 16 SEER registries. A free smartphone and web application is provided for readers to access and test the predictive models (www.meningioma.app). Future model improvements and prospective replication will be necessary to demonstrate true clinical utility. Rather than being used in isolation, we expect that the proposed models will be integrated into larger and more comprehensive models that integrate imaging and molecular biomarkers. Whether for meningiomas or other tumors of the CNS, the power of these methods to make individual-patient predictions could lead to improved diagnosis, patient counseling, and outcomes.
Kuvan: High court case challenges NICE’s appraisal
Authors: Elisabeth Mahase
Journal: BMJ (2020)

A case that is due to be heard in the High Court on 30 January will challenge how the UK National Institute for Health and Clinical Excellence planned to review the orphan drug sapropterin dihydrochloride (marketed as Kuvan), a treatment for the rare genetic disorder phenylketonuria (PKU).

The judicial review revolves around 11 year old Cait Cotter, who has the disorder and whose claim is being funded through legal aid.

The fact that NICE chose to use its standard technology protocol to appraise sapropterin for use on the NHS made approval less likely, said Cotter’s lawyer Peter Todd, leaving patients like his client unable to get the treatment on the NHS. He claims that NICE should instead have used the highly specialised technology evaluation, which was introduced in 2013 for appraisal of drugs for very rare conditions, …
IASLC Multidisciplinary Recommendations for Pathologic Assessment of Lung Cancer Resection Specimens After Neoadjuvant Therapy
Authors: William D. Travis, Sanja Dacic, Ignacio Wistuba, Lynette Sholl, Prasad Adusumilli, Lukas Bubendorf, Paul Bunn, Tina Cascone, Jamie Chaft, Gang Chen, Teh-Ying Chou, Wendy Cooper, Jeremy J. Erasmus, Carlos Gil Ferreira, Jin-Mo Goo, John Heymach, Fred R. Hirsch, Hidehito Horinouchi, Keith Kerr, Mark Kris, Deepali Jain, Young T. Kim, Fernando Lopez-Rios, Shun Lu, Tetsuya Mitsudomi, Andre Moreira, Noriko Motoi, Andrew G. Nicholson, Ricardo Oliveira, Mauro Papotti, Ugo Pastorino, Luis Paz-Ares, Giuseppe Pelosi, Claudia Poleri, Mariano Provencio, Anja C. Roden, Giorgio Scagliotti, Stephen G. Swisher, Erik Thunnissen, Ming S. Tsao, Johan Vansteenkiste, Walter Weder, Yasushi Yatabe
Journal: Journal of Thoracic Oncology (2020)
Microbiome Anomalies in Allogeneic Hematopoietic Cell Transplantation
Authors: Zaker I. Schwabkey, Robert R. Jenq
Journal: Annual Review of Medicine (2020)

The microbiome is an integrated part of the human body that can modulate a variety of disease processes and affect prognosis, treatment response, complications, and outcomes. The importance of allogeneic hematopoietic cell transplantation in cancer treatment has resulted in extensive investigations on the interaction between the microbiome and this treatment modality. These investigations are beginning to lead to clinical trials of microbiome-targeted interventions. Here we review some of these discoveries and describe strategies being investigated to manipulate the microbiome for favorable outcomes, such as the proper selection and timing of antibiotics, type of diet and route of administration, probiotics, prebiotics, and fecal microbiota transplantation.
Knocking ’em Dead: Pore-Forming Proteins in Immune Defense
Authors: Xing Liu, Judy Lieberman
Journal: Annual Review of Immunology (2020)

Immune cells use a variety of membrane-disrupting proteins [complement, perforin, perforin-2, granulysin, gasdermins, mixed lineage kinase domain-like pseudokinase (MLKL)] to induce different kinds of death of microbes and host cells, some of which cause inflammation. After activation by proteolytic cleavage or phosphorylation, these proteins oligomerize, bind to membrane lipids, and disrupt membrane integrity. These membrane disruptors play a critical role in both innate and adaptive immunity. Here we review our current knowledge of the functions, specificity, activation, and regulation of membrane-disrupting immune proteins and what is known about the mechanisms behind membrane damage, the structure of the pores they form, how the cells expressing these lethal proteins are protected, and how cells targeted for destruction can sometimes escape death by repairing membrane damage.
ROS-responsive nano-drug delivery system combining mitochondria-targeting ceria nanoparticles with atorvastatin for acute kidney injury
Authors: Hui Yu, Feiyang Jin, Di Liu, Gaofeng Shu, Xiaojuan Wang, Jing Qi, Mingchen Sun, Ping Yang, Saiping Jiang, Xiaoying Ying, Yongzhong Du
Journal: Theranostics (2020)

Acute kidney injury (AKI) caused by sepsis is a serious disease which mitochondrial oxidative stress and inflammatory play a key role in its pathophysiology.Ceria nanoparticles hold strong and recyclable reactive oxygen species (ROS)-scavenging activity, have been applied to treat ROS-related diseases.However, ceria nanoparticles can't selectively target mitochondria and the ultra-small ceria nanoparticles are easily agglomerated.To overcome these shortcomings and improve therapeutic efficiency, we designed an ROS-responsive nano-drug delivery system combining mitochondria-targeting ceria nanoparticles with atorvastatin for acute kidney injury.Methods: Ceria nanoparticles were modified with triphenylphosphine (TCeria NPs), followed by coating with ROS-responsive organic polymer (mPEG-TK-PLGA) and loaded atorvastatin (Atv/PTP-TCeria NPs).The physicochemical properties, in vitro drug release profiles, mitochondria-targeting ability, in vitro antioxidant, anti-apoptotic activity and in vivo treatment efficacy of Atv/PTP-TCeria NPs were examined.Results: Atv/PTP-TCeria NPs could accumulate in kidneys and hold a great ability to ROS-responsively release drug and TCeria NPs could target mitochondria to eliminate excessive ROS.In vitro study suggested Atv/PTP-TCeria NPs exhibited superior antioxidant and anti-apoptotic activity.In vivo study showed that Atv/PTP-TCeria NPs effectively decreased oxidative stress and inflammatory, could protect the mitochondrial structure, reduced apoptosis of tubular cell and tubular necrosis in the sepsis-induced AKI mice model.Conclusions: This ROS-responsive nano-drug delivery system combining mitochondria-targeting ceria nanoparticles with atorvastatin has favorable potentials in the sepsis-induced AKI therapy.
可変負荷利得係数による比例補助換気法(PAV+)と圧補助換気法(PSV)の生理学的比較 | 文献情報 | J-GLOBAL 科学技術総合リンクセンター
Authors: R Costa, G Spinazzola, F Cipriani, G Ferrone, O Festa, A Arcangeli, M Antonelli, R Proietti, G Conti
Journal: Intensive Care Medicine (2011)
Frat2はMLL融合によるRacの発癌性活性化を調節する | 文献情報 | J-GLOBAL 科学技術総合リンクセンター
Authors: Walf-Vorderwuelbecke Vanessa, DE Boer Jasper, J Horton Sarah, Van Amerongen Renee, Proost Natalie, Berns Anton, Williams Owen
Journal: Blood (2012)
99P Zoledronic Acid in Combination with Serine/Threonine Phosphatase Inhibitors Induces Cytotoxicity and Apoptosis in Human Breast Cancer Cells via Decreasing the Activities of Pp1 and Pp2A
Authors: Z.G. Surmeli, P. Gursoy, B. Cakar, K. Asli, H. Atmaca, C. Sezgin, B. Karabulut, R. Uslu, B. Karaca
Journal: Annals of Oncology (2012)
Characterizing Hepatitis C Virus–Specific CD4+ T Cells Following Viral‐Vectored Vaccination, Directly Acting Antivirals, and Spontaneous Viral Cure
Authors: Felicity Hartnell, Ilaria Esposito, Leo Swadling, Anthony Brown, Chansavath Phetsouphanh, Catherine de Lara, Chiara Gentile, Bethany Turner, Lucy Dorrell, Stefania Capone, Antonella Folgori, Eleanor Barnes, Paul Klenerman
Journal: Hepatology (2020)

Background and Aims Induction of functional helper CD4 + T cells is the hallmark of a protective immune response against hepatitis C virus (HCV), associated with spontaneous viral clearance. Heterologous prime/boost viral vectored vaccination has demonstrated induction of broad and polyfunctional HCV‐specific CD8 + T cells in healthy volunteers; however, much less is known about CD4 + T‐cell subsets following vaccination. Approach and Results We analyzed HCV‐specific CD4 + T‐cell populations using major histocompatibility complex class II tetramers in volunteers undergoing HCV vaccination with recombinant HCV adenoviral/modified vaccinia Ankara viral vectors. Peptide‐specific T‐cell responses were tracked over time, and functional (proliferation and cytokine secretion) and phenotypic (cell surface and intranuclear) markers were assessed using flow cytometry. These were compared to CD4 + responses in 10 human leukocyte antigen–matched persons with HCV spontaneous resolution and 21 chronically infected patients treated with directly acting antiviral (DAA) therapy. Vaccination induced tetramer‐positive CD4 + T cells that were highest 1‐4 weeks after boosting (mean, 0.06%). Similar frequencies were obtained for those tracked following spontaneous resolution of disease (mean, 0.04%). In addition, the cell‐surface phenotype (CD28, CD127) memory subset markers and intranuclear transcription factors, as well as functional capacity of peptide‐specific CD4 + T‐cell responses characterized after vaccination, are comparable to those following spontaneous viral resolution. In contrast, helper responses in chronic infection were infrequently detected and poorly functional and did not consistently recover following HCV cure. Conclusions Helper CD4 + T‐cell phenotype and function following HCV viral vectored vaccination resembles “protective memory” that is observed following spontaneous clearance of HCV. DAA cure does not promote resurrection of exhausted CD4 + T‐cell memory in chronic infection.
Beyond GWAS in Atrial Fibrillation Genetics
Authors: Sander W. van der Laan, Folkert. W. Asselbergs
Journal: Circulation Research (2020)

Atrial fibrillation (AF) is one of the leading causes of cardiovascular diseases.Despite tremendous progress in medicine, over 33 million individuals suffer from AF with a lifetime risk of ≈1 in 3 for individuals from European ancestry. 1The causes leading up to AF are myriad: environmental, behavioral, and genetic factors influence and modify the extent of disease. 1
In search of genetic factors predisposing to familial hairy cell leukemia (HCL): exome-sequencing of four multiplex HCL pedigrees
Authors: Alexander Pemov, Anand Pathak, Samantha J. Jones, Ramita Dewan, Jessica Merberg, Sirisha Karra, Jung Kim, Evgeny Arons, Sarangan Ravichandran, Brian T. Luke, Shalabh Suman, Meredith Yeager, Martin J. S. Dyer, Henry T. Lynch, Mark H. Greene, Neil E. Caporaso, Robert J. Kreitman, Lynn R. Goldin, John J. Spinelli, Angela Brooks-Wilson, Mary L. McMaster, Douglas R. Stewart
Journal: Leukemia (2020)
Author Correction: Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
Authors: Julia Marschallinger, Tal Iram, Macy Zardeneta, Song E. Lee, Benoit Lehallier, Michael S. Haney, John V. Pluvinage, Vidhu Mathur, Oliver Hahn, David W. Morgens, Justin Kim, Julia Tevini, Thomas K. Felder, Heimo Wolinski, Carolyn R. Bertozzi, Michael C. Bassik, Ludwig Aigner, Tony Wyss-Coray
Journal: Nature Neuroscience (2020)
Siglecs as Immune Cell Checkpoints in Disease
Authors: Shiteng Duan, James C. Paulson
Journal: Annual Review of Immunology (2020)

Sialic acid–binding immunoglobulin-type lectins (Siglecs) are expressed on the majority of white blood cells of the immune system and play critical roles in immune cell signaling. Through recognition of sialic acid–containing glycans as ligands, they help the immune system distinguish between self and nonself. Because of their restricted cell type expression and roles as checkpoints in immune cell responses in human diseases such as cancer, asthma, allergy, neurodegeneration, and autoimmune diseases they have gained attention as targets for therapeutic interventions. In this review we describe the Siglec family, its roles in regulation of immune cell signaling, current efforts to define its roles in disease processes, and approaches to target Siglecs for treatment of human disease.
Senior medics urge GMC to set up central register of doctors’ declared interests
Authors: Gareth Iacobucci
Journal: BMJ (2020)

Doctors’ leaders have urged the General Medical Council to establish a central register for UK doctors to declare their interests in order to improve transparency.

In a letter to GMC chair Clare Marx, shared with The BMJ , 11 senior doctors (full list of signatories below) called on the regulator to show leadership on the matter by taking “definitive, positive action” to tackle long standing deficiencies in the current system.

The letter pointed to “substantial evidence” that doctors’ current declarations of interests are incomplete, and lack enough information to enable “informed and fair” judgments.

It argues that voluntary registers set up by the …
急性心筋梗塞の日本人患者に対するGRACEリスクスコアとTIMIリスクスコアの予後的意義(三重ACS登録からの報告) | 文献情報 | J-GLOBAL 科学技術総合リンクセンター
Authors: Masuda Jun, Tanigawa Takashi, Seko Tetsuya, Kitamura Tetsuya, Hoshino Kozo, Kakimoto Hitoshi, Mizutani Hideo, Kumagai Naoto, Nakamura Mashio, Ito Masaaki
Journal: Circulation (2014)
90P Identification in Breast Cancer Cells of A Novel Mechanism of Csf-1R Signaling Which Involves its Nuclear Translocation and Binding to the Promoter of Genes Relevant to Cancer Progression
Authors: E. Rovida, V. Barbetti, A. Morandi, M. Riverso, S. Bessi, A. Giannini, A. Di Leo, P. Dello Sbarba
Journal: Annals of Oncology (2012)
ATS/ERS/JRS/ALATの公式声明: 特発性肺線維症: 診断および管理に関するエビデンスに基づくガイドライン
Authors: Raghu Ganesh, R Collard Harold, J Egan Jim, J Martinez Fernando, Behr Juergen, K Brown Kevin, V Colby Thomas, Cordier Jean-Francois, R Flaherty Kevin, A Lasky Joseph, A Lynch David, H Ryu Jay, J Swigris Jeffrey, U Wells Athol, Ancochea Julio, Bouros Demosthenes, Carvalho Carlos, Costabel Ulrich, Ebina Masahito, M Hansell David, Johkoh Takeshi, Kim Dong Soon, E King Talmadge, Kondoh Yasuhiro, Myers Jeffrey, L Mueller Nestor, G Nicholson Andrew, Richeldi Luca, Selman Moises, F Dudden Rosalind, S Griss Barbara, L Protzko Shandra, J Schuenemann Holger
Journal: American Journal of Respiratory and Critical Care Medicine (2011)
Different human resting memory CD4 <sup>+</sup> T cell subsets show similar low inducibility of latent HIV-1 proviruses
Authors: Kyungyoon J. Kwon, Andrew E. Timmons, Srona Sengupta, Francesco R. Simonetti, Hao Zhang, Rebecca Hoh, Steven G. Deeks, Janet D. Siliciano, Robert F. Siliciano
Journal: Science Translational Medicine (2020)

Latent replication-competent HIV-1 proviruses in different memory T cell subsets show no differences in viral gene transcription after T cell activation.
Author Correction: ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response
Authors: Sankari Nagarajan, Shalini V. Rao, Joseph Sutton, Danya Cheeseman, Shanade Dunn, Evangelia K. Papachristou, Jose-Enrique Gonzalez Prada, Dominique-Laurent Couturier, Sanjeev Kumar, Kamal Kishore, Chandra Sekhar Reddy Chilamakuri, Silvia-Elena Glont, Emily Archer Goode, Cara Brodie, Naomi Guppy, Rachael Natrajan, Alejandra Bruna, Carlos Caldas, Alasdair Russell, Rasmus Siersbæk, Kosuke Yusa, Igor Chernukhin, Jason S. Carroll
Journal: Nature Genetics (2020)
A behaviour change package to prevent hand dermatitis in nurses working in the National Health Service: results of a cluster randomized controlled trial
Authors: I. Madan, V. Parsons, G. Ntani, D. Coggon, A. Wright, J. English, P. McCrone, J. Smedley, L. Rushton, C. Murphy, B. Cookson, H.C. Williams
Journal: British Journal of Dermatology (2020)

Occupational hand dermatitis poses a serious risk for nurses.To evaluate the clinical and cost-effectiveness of a complex intervention in reducing the prevalence of hand dermatitis in nurses METHODS: This was a cluster randomized controlled trial conducted at 35 hospital trusts, health boards or universities in the UK. Participants were (i) first-year student nurses with a history of atopic conditions or (ii) intensive care unit (ICU) nurses. Participants at intervention sites received access to a behavioural change programme plus moisturizing creams. Participants at control sites received usual care. The primary outcome was the change of prevalent dermatitis at follow-up (adjusted for baseline dermatitis) in the intervention vs. the control group. Randomization was blinded to everyone bar the trials unit to ensure allocation concealment. The trial was registered on the ISRCTN registry: ISRCTN53303171.Fourteen sites were allocated to the intervention arm and 21 to the control arm. In total 2040 (69·5%) nurses consented to participate and were included in the intention-to-treat analysis. The baseline questionnaire was completed by 1727 (84·7%) participants. Overall, 789 (91·6%) ICU nurses and 938 (84·0%) student nurses returned completed questionnaires. Of these, 994 (57·6%) had photographs taken at baseline and follow-up (12-15 months). When adjusted for baseline prevalence of dermatitis and follow-up interval, the odds ratios (95% confidence intervals) for hand dermatitis at follow-up in the intervention group relative to the controls were 0·72 (0·33-1·55) and 0·62 (0·35-1·10) for student and ICU nurses, respectively. No harms were reported.There was insufficient evidence to conclude whether our intervention was effective in reducing hand dermatitis in our populations. Linked Comment: Brans. Br J Dermatol 2020; 183:411-412.
Combination anti-HIV-1 antibody therapy is associated with increased virus-specific T cell immunity
Authors: Julia Niessl, Amy E. Baxter, Pilar Mendoza, Mila Jankovic, Yehuda Z. Cohen, Allison L. Butler, Ching-Lan Lu, Mathieu Dubé, Irina Shimeliovich, Henning Gruell, Florian Klein, Marina Caskey, Michel C. Nussenzweig, Daniel E. Kaufmann
Journal: Nature Medicine (2020)
テトラヒドロフランジオール類(THF-ジオール),ロイコトキシンジオール類(LTX-ジオール)とラットにおける内分泌撹乱 | 文献情報 | J-GLOBAL 科学技術総合リンクセンター
Authors: M Markaverich Barry, Alejandro Mary, Thompson Trellis, Mani Shaila, Reyna Andrea, Portillo Wendy, Sharp John, Turk John, R Crowley Jan
Journal: Environmental Health Perspectives (2007)