AB0501 CLINICAL ANALYSIS OF BONE MINERAL DENSITY IN PATIENTS WITH NEW-ONSET SYSTEMIC LUPUS ERYTHEMATOUS
Authors: Xiaoli Deng, LI Xinyi
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> Osteoporosis in patients with systemic lupus erythematosus (SLE) is always thought to be GIOP (induced by glucocorticoid). Yet in our practice, there were some patients who developed osteoporosis at the onset of SLE, before the use of glucocorticoid and immunosuppressants. The clinical feature of these patients were not known by us clearly. <h3>Objectives</h3> This study aimed to investigate the BMD (bone marrow density) status and clinical characteristics of treatment-naive patients with newly diagnosed SLE. <h3>Methods</h3> Patients admitted to Peking University Third Hospital from 2009-2016, who were newly diagnosed as SLE and had no previous medical history that would had affected their BMD, were enrolled in this study. Demographic and clinical data were recorded. BMD of the lumbar vertebrae and femoral necks were measured with dual-energy X-ray absorptiometry, and patients were stratified as normal and abnormal BMD groups (including ostepenia and osteoporosis). <h3>Results</h3> Eighty-nine SLE patients with a mean age of 28.7 ± 8.9 years were included in the study (Table1). Approximately 36% of these patients had normal BMD, 49% had osteopenia, and 15% had osteoporosis. The SLE Disease Activity Index (SLEDAI) in the abnormal BMD group was lower than that in the normal BMD group (9.4 ± 4.5 vs 12.1 ± 5.8, P= 0.028). The body mass index (BMI) was significantly lower in the abnormal than normal BMD group (20.5±3.5 kg/m<sup>2</sup> vs 24.2±3.2 kg/m<sup>2</sup>, P = 0.00). The total cholestenone (TC) and low density lipoprotein (LDL) were lower in the abnormal than normal BMD group (4.3±1.7 mmol/L vs 2.4±1.2 mmol/L, P =0.04; 4.9±1.3 mmol/L vs 2.9±0.9 mmol/L, P = 0.033). The multisystem damage and nervous system involvement were less in the abnormal than normal BMD group (χ<sup>2</sup> = 5.996, P = 0.014 and χ<sup>2</sup>= 8.169, P = 0.004). Multivariate analysis showed that BMI (correlation coefficient = 0.484, P &lt; 0.001) and multisystem damage (correlation coefficient = 0.258, P = 0.003) were positively correlated with BMD. <h3>Conclusion</h3> Low BMI, SLEDAI and less multisystem damage may be risk factors of BMD abnormalities in newly diagnosed SLE patients. <h3>References</h3> [1] Rivas-Larrauri, F. and M.A. Yamazaki-Nakashimada, Systemic Lupus Erythematosus: Is It One Disease? Reumatología Clínica (English Edition), 2016. 12(5): p. 274-281. [2] Bultink, I.E. and W.F. Lems, Systemic lupus erythematosus and fractures. RMD Open, 2015. 1(Suppl 1): p. e000069. [3] ROSALIND RAMSEY-GOLDMAN, J.E.D., CHENG-FANG HUANG,et al, FREQUENCY OF FRACTURES IN WOMEN WITH SYSTEMIC LUPUS ERYTHEMATOSUS Comparison with United States Population Data. ARTHRITIS &amp; RHEUMATISM, 1999. 42. [4] Carli, L., et al., Risk factors for osteoporosis and fragility fractures in patients with systemic lupus erythematosus. Lupus Sci Med, 2016. 3(1): p. e000098. <h3>Acknowledgement</h3> This study was supported by a Project of the National Natural Science Foundation of China (81501390). <h3>Disclosure of Interests</h3> None declared