Type 1 Diabetes in People Hospitalized for COVID-19: New Insights From the CORONADO Study
Authors: Matthieu Wargny, Pierre Gourdy, Lisa Ludwig, Dominique Seret-Bégué, Olivier Bourron, Patrice Darmon, Coralie Amadou, Matthieu Pichelin, Louis Potier, Charles Thivolet, Jean-François Gautier, Samy Hadjadj, Bertrand Cariou, Matthieu Wargny, Pascale Mahot, Bertrand Cariou, Samy Hadjadj, Matthieu Pichelin, Anne-Laure Fournier-Guilloux, Nicolas Mauduit, Edith Bigot-Corbel, Anne-Sophie Boureau, Laure De Dekcer, Audrey Ernould, Claire Primot, Anne Seguin, Marielle Joliveau, Sonia Pouvreau, Chloé Fournier, Jeremy Thureau, Edith Fonteneau, Pamela Hublain, Carole Agasse, Mathilde De Kergaradec, Vincent Minville, Fanny Vardon-Bounes, Guillaume Martin-Blondel, Pierre Gourdy, Blandine Tramunt, Marie-Christine Turnin, Hélène Hanaire, Jean-Michel Mansuy, Didier Fabre, Marie-Blanche Arhainx, Laurent Cazals, Laure Combes, Emmanuelle Lami, Mallory Cianferani, Bruno Megarbane, Pierre Leroy, Jean-François Gautier, Tiphaine Vidal-Trecan, Jean-Pierre Riveline, Jean-Louis Laplanche, Stéphane Mouly, Louis Potier, Ronan Roussel, Malak Taher, Yawa Abouleka, Fetta Yaker, Aurelie Carlier, Anne Boutten, Marilyne Hallot-Feron, Fadila Mourah, Charles Thivolet, Emilie Blond, Muriel Rolland, Josep Verdecho Mendez, Marine Alexandre, Julien Pottecher, Emilie Richer, Laurent Meyer, Florina Luca, Jean-Marc Lessinger, Thibault Bahougne, Bruno Guerci, Lisa Ludwig, Siham Benzirar, Catherine Malaplate, Thierry Matton, Julien Poissy, Karine Faure, Pierre Fontaine, Florence Baudoux, Anne Vambergue, Jean David Pekar, Marc Lambert, Cécile Yelnik, Amélie Bruandet, Laurent Petit, Didier Neau, Vincent Rigalleau, Annie Berard, Amandine Galioot, Remy Coudroy, Arnaud Thille, René Robert, France Roblot-Cazenave, Blandine Rammaert, Pierre Jean Saulnier, Xavier Piguel, Nesrine Benhenda, Camille Husson, Celine Olivier, Florence Torremocha, Mathilde Fraty, Marie Flamen D'assigny, Aurelie Miot, Valentin Bossard, Kada Klouche, Alain Makinson, Ariane Sultan, Jean-Baptiste Bonnet, Vincent Foulongne, Florence Galtier, Cécile Aubron, Séverine Ansart, Véronique Kerlan, Pascale Quiniou, Jean-Luc Carre, Stéphane Quesnot, Bruno Laviolle, Carole Schwebel, Olivier Epaulard, Pierre-Yves Benhamou, Cécile Betry, Anne-Laure Borel, Sandrine Lablanche, Dorra Guergour, Catherine Duclos, Emmanuel Cosson, Erwan Guyot, Aurore Deniau, Phucthutrang Nguyen, Yves Reznik, Michael Joubert, Stéphane Allouche, Lydia Guittet, Steven Grange, Manuel Etienne, Gaëtan Prévost, Valéry Brunel, Jean-Christophe Lagier, Didier Raoult, Anne Dutour, Bénédicte Gaborit, Sandrine Boulllu, Patrice Darmon, Adèle Lasbleiz, Mathieu Cerino, Fanny Romain, Marie Houssays, Jean Pierre Quenot, Lionel Piroth, Bruno Vergès, Laurence Duvillard, Bernard Bonnotte, Alain Mercat, Vincent Dubee, Ingrid Allix, Patrice Rodien, Robin Dhersin, Maylis Lebeault, Wojciech Trzepizur, Jocelyne Loison, Antoine Brangier, Pierre Asfar, Pascal Reynier, Françoise Larcher, Françoise Joubaud, Marie-Rita Andreu, Geoffrey Urbanski, Laurent Hubert, Cedric Annweiler, Jean Dellamonica, Johan Courjon, Nicolas Chevalier, Giulia Chinetti, Magda Chafai, Bruno Mourvillier, Firouze Bani-Sadr, Sarra Barraud, Brigitte Delemer, Philippe Gillery, Pascale Labedade, Amélie Chabrol, Alfred Penfornis, Catherine Petit, Coralie Amadou, Maxime Adler, Clément Dubost, Pierre-Louis Conan, Lyse Bordier, Franck Ceppa, Cyril Garcia, Mathilde Sollier, Olivier Dupuy, Sophie Laplance, Olivier Billuart, Marie Joseph Aroulanda, Frédérique Olivier, Florence Ayon, Nathalie Wilhelm, Loic Epelboin, Nadia Sabbah, Aurelie Charpin, Pierre Squara, Olivier Belliard, Claude Dubois, Michel Marre, Johann Auchabie, Roxane Courtois, Thierry Duriez, Tiphaine Mergey, Laura Vallee, Laetitia Seguin, Abdallah Al-Salameh, Jean-Philippe Lanoix, Sandrine Soriot-Thomas, Anne-Marie Bourgeois-Descouls, Rachel Desailloud, Natacha Germain, Bogdan Galusca, Gwenaelle Belleton, Nesrine Marouani, Delia Palaghiu, Amira Hammour, Fernando Berdaguer, Thimothée Klopfenstein, Hajer Zayet, Patrice Winiszewski, Marie Zanusso, Pauline Garnier, Ingrid Julier, Karim Hamzaoui, Sophie Marty-Gres, Tarik El Sadki, Lucile Cadot, Jean-Louis Dubost, Céline Gonfroy, Catherine Campinos, Pascale Martres, Marie Pierre Coulhon, Nicolas Allou, Marwa Bachir, Stella Hoang, Candice Kembellec, Olivia Suply, Fatima Kharcha, Anne-Claire Devouge, Anna Flaus-Furmanuk, Isabelle Madeline, Vincent Ehinger, Sophie Bastard, Loic Raffray, Frederic Renou, Aude Bojarski, Caroline Paul, Karine Borsu, Angelique Gorlin, Servane Di Bernardo, Carole Truong Van Ut, Stephane Renaud, Antoine Vignoles, Emilie Foch, Laurie Masse, Hubert Grand, Helene Ferrand, Christelle Raffaitin-Cardin, Hadjer Zellagui, Celine Castang-Brachet, Frederique Boury, Ana Alvarez Tena, Isabelle Moura, Pierre Kalfon, Juliana Darasteanu, Arnaud Monier, Pascal Foucault, Alexandra Depuille, Stéphanie Laugier-Robiolle, Patrick Caneiro, Maud Basso, Etienne Larger, Samir Bouam, Wahiba Benzenati, Leila Ait Bachir, Camille Cussac Pillegand, Marc Vasse, Christophe Michard, Nathanaëlle Montanier, Luc Millot, Françoise Crepet, Danielle Ratsimba, Kevin Bouiller, Sophie Borot, Isabelle Bruckert, Annie Clergeot, Franck Schillo, Dorothée Vignes, Muriel Bourgeon-Ghittori, Hamoud Lachgar, Claire Lambert De Cursay, Stéphane Levante, Jean Charles Auregan, Antoine Merlet, Cécile Zaragoza, Gwénaëlle Arnault, Anne-Gaëlle Le Loupp, Olivier Lesieur, Mariam Roncato-Saberan, Didier Gouet, Romain Lemarie, Hong-An Allano, Emmanuel Vivier, Caroline Pariset, Cédric Luyton, Lucien Marchand, Fanny Doroszewski, Matthieu Pecquet, Laurent Perard, Sylvie Vuillermoz-Blas, Nicolas Kacki, Patricia Charrier, Amélie Ducet-Boiffard, Françoise Desroys Du Roure, Olivier Bourron, Dominique Bonnefont-Rousselot, Suzanne Laroche, Franck Phan, Agnès Hartemann, Cyrielle Caussy, Emmanuel Disse, Emilie Blond, Claude Guerin, Thomas Perpoint, Philippe Moulin, Régine Cartier, Geoffroy Hariri, Dorothée Chopin, Camille Vatier, Nathalie Bourcigaux, Emmanuelle Chaigneau, Sophie Christin-Maitre, Bruno Donadille, Bruno Feve, Sophie Lamothe, Julie Sarfati, Pascal Pernet, Anne Chambon, Delphine Demarsy, Hugo Campagne, Françoise Latil-Plat, Monica Berne, Marilyne Grinand, Marion Touzet, Aydrey Zabulon, Jocelyne Craspag, Catherine Ledoux, Cedric Contaret, Blandine Janand-Delenne, Anaïs Giraud, Marie Lou Lacrimini, Joëlle Arrivie, Deborah Ancelle, Carine Guillois, Bénédicte Fremy, Amina Chaalal, Gaëlle Barrande, Anne Dorange, Eglantine Rouanet, Dominique Seret-Begue, Audrey Saoud, Anne-Marie Guedj, Nathalie Bedos, Fritz-Line Velayoudom, Marie Dumas, Benoite Gonda, Christine Coffin, Stéphanie Gibiat, Myriam Lungo, Chantal Bully, Pierre Serusclat, Stella Bully, Patricia Carre, Jean-Philippe Leberre, Carlos Elkhoury, Marine Thieux, Laetitia Paradisi-Prieur
Journal: Diabetes Care (2020)

Since the start of the coronavirus disease 2019 (COVID-19) pandemic, patients with diabetes were rapidly recognized as a high-risk population for severe disease. Indeed, a high prevalence of diabetes among patients with COVID-19 who required hospitalization has been consistently reported, reaching 33.8% in 5,700 people hospitalized for COVID-19 in the New York City area (1). In addition, diabetes was associated with more than a doubled risk of intensive care unit (ICU) admission and more than a tripled risk of death (2). However, precise data regarding the type of diabetes are scarce. We report here the clinical characteristics and early prognosis of patients with type 1 diabetes (T1D) hospitalized for COVID-19 in the nationwide multicenter observational CORONADO (Coronavirus SARS-CoV-2 and Diabetes Outcomes) study (3).

The aim of the CORONADO study was to describe the phenotypic characteristics and prognosis of patients with diabetes admitted with COVID-19 between 10 March and 10 April 2020 in 68 French hospitals. The protocol (ClinicalTrials.gov reg. no. NCT04324736) obtained all regulatory approvals as recently described (3). Inclusion criteria were 1 ) hospitalization for biologically and/or clinically/radiologically attested COVID-19 and 2 ) personal history of diabetes or newly diagnosed diabetes on admission. The composite primary end point combined tracheal intubation for mechanical ventilation and/or death on day 7 (D7). Secondary outcomes included death, tracheal intubation, and discharge on D7. Classification of diabetes was recorded in the electronic case report form as noted in the medical file by the physician in charge of the patient. In the present subanalysis, patients in whom diabetes was diagnosed on admission were excluded since the etiological diagnosis had not been formally established. All cases noted as T1D were carefully reviewed by local investigators and the steering committee …