tbuckley/cabot-search huggingface dataset:
International Rare Cancers Initiative Multicenter Randomized Phase II Trial of Cisplatin and Fluorouracil Versus Carboplatin and Paclitaxel in Advanced Anal Cancer: InterAAct
Authors: Sheela Rao, Francesco Sclafani, Cathy Eng, Richard A. Adams, Marianne G. Guren, David Sebag-Montefiore, Al Benson, Annette Bryant, Clare Peckitt, Eva Segelov, Amitesh Roy, Matt T. Seymour, Jack Welch, Mark P. Saunders, Rebecca Muirhead, Peter O’Dwyer, John Bridgewater, Shree Bhide, Rob Glynne-Jones, Dirk Arnold, David Cunningham
Journal: Journal of Clinical Oncology (2020)

To compare cisplatin plus fluorouracil (FU) versus carboplatin plus paclitaxel in chemotherapy-naïve advanced anal cancer to establish the optimal regimen.
Association of Immune Checkpoint Inhibitor Therapy With Survival in Patients With Cancers With <i>MUC16</i> Variants
Authors: Yunfang Yu, Dagui Lin, Anlin Li, Yongjian Chen, Qiyun Ou, Hai Hu, Herui Yao
Journal: JAMA Network Open (2020)

This cohort study investigates whether MUC16 variation could be a useful biomarker for immune checkpoint inhibitor (ICI) therapy.
BAFF selectively enhances the survival of plasmablasts generated from human memory B cells (vol 112, pg 286, 2003)
Authors: DT Avery, SL Kalled, JI Ellyard, C Ambrose, SA Bixler, M Thien, R Brink, F Mackay, PD Hodgkin, SG Tangye
Journal: Journal of Clinical Investigation (2004)
Decoupled pH‐ and Thermo‐Responsive Injectable Chitosan/PNIPAM Hydrogel via Thiol‐Ene Click Chemistry for Potential Applications in Tissue Engineering
Authors: Haichang Ding, Baoqiang Li, Zonglin Liu, Gang Liu, Shouzhi Pu, Yujie Feng, Dechang Jia, Yu Zhou
Journal: Advanced Healthcare Materials (2020)

Abstract Stimuli‐responsive chitosan (CS) hydrogels exhibit great potential for drug delivery and tissue engineering; however, the structure of these stimuli‐responsive CS hydrogels, such as dual pH‐ and thermo‐responsive hydrogels, is difficult to control or needs additional crosslinking agents. Here, a new dual pH‐ and thermo‐responsive hydrogel system is developed by combining pH‐responsive C 6 ‐OH allyl‐modified CS (OAL‐CS) with thermo‐responsive poly( N ‐isopropylacrylamide) (PNIPAM). The thiol groups in PNIPAM and the allyl groups in OAL‐CS can rapidly form crosslinking hydrogel network by “thiol‐ene” click chemistry under UV irradiation. As expected, the swelling ratio of the OAL‐CS/PNIPAM hydrogel can be controlled by changing pH and temperature. Moreover, the hydrogel displays non‐cytotoxic nature toward human bone marrow mesenchymal stem cells, and the histological analyses reveal the subcutaneous tissue with no signs of inflammation after 5 days of injection in vivo. The results indicate that the new OAL‐CS/PNIPAM hydrogel has potential to serve as a smart injectable platform for application in drug delivery and tissue engineering.
Induction of sustained unresponsiveness after egg oral immunotherapy compared to baked egg therapy in children with egg allergy
Authors: Edwin H. Kim, Tamara T. Perry, Robert A. Wood, Donald Y.M. Leung, M. Cecilia Berin, A. Wesley Burks, Christine B. Cho, Stacie M. Jones, Amy Scurlock, Scott H. Sicherer, Alice K. Henning, Peter Dawson, Robert W. Lindblad, Marshall Plaut, Hugh A. Sampson
Journal: Journal of Allergy and Clinical Immunology (2020)
Abstract 15257: Cold Inducible RNA Binding Protein (CIRP) Expression is Regulated by Mild Hypothermia and Elevated by Therapeutic Hypothermia Following Cardiac Arrest
Authors: Justin Varughese, Hannah J Zhang, Mei Han, Yong Hu Fang, David G Beiser, Willard W Sharp
Journal: Circulation (2013)

Introduction: Cold Inducible RNA Binding Protein (CIRP) is a novel protein known to alter cellular function specifically in response to mild hypothermia (32°C-34°C). The relationship of CIRP to the...
The ICD committee of the Japanese Heart Rhythm Society : ICD therapy for idiopathic ventricular fibrillation in Japan-The ICD-WEB registry administered by the Japanese Heart Rhythm Society
Authors: A Shimizu, Takashi Nitta, Katsuhiko Imai, Takashi Kurita, Yoshinori Kobayashi, Shinichi Niwano, Shigeyuki Watanabe, Kyouko Soejima, Naohiko Abe
Journal: Circulation (2008)
FRI0371 BETULINIC ACID INHIBITS RANKL-INDUCED OSTEOCLASTOGENESIS VIA ATTENUATING AKT, NF-KB, AND PLCG2-CA2+ SIGNALING AND PREVENTS INFLAMMATORY BONE LOSS
Authors: C. H. Lee, C. H. Chung, J. Y. Kim, Y. J. Choi, W. H. Yoo, M. S. Lee
Journal: Annals of the Rheumatic Diseases (2020)

Background: Betulinic acid (BA), a natural plant-derived pentacyclic triterpenoid compound, is known to possess numerous pharmacological and biochemical properties including anti-inflammatory, anti-cancer, and anti-adipogenic activity. Objectives: we investigated that BA could suppress RANKL-induced osteoclastogenesis and bone resorption. Results: BA significantly suppressed osteoclastogenesis by decreasing the phosphorylation of Akt and IkB, as well as PLCγ2-Ca 2+ signaling, in pathways involved in early osteoclastogenesis as well as through the subsequent suppression of c-Fos and NFATc1. The inhibition of these pathways by BA was once more confirmed by retrovirus infection of constitutively active (CA)-Akt and CA-Ikkβ retrovirus and measurement of Ca 2+ influx. BA also significantly inhibited the expression of osteoclastogenesis-specific marker genes. Moreover, we found that BA administration restored the bone loss induced through acute lipopolysaccharide injection in mice by a micro-CT and histological analysis. Conclusion: Our findings suggest that BA is a potential therapeutic candidate for bone diseases involving osteoclasts. Disclosure of Interests: None declared
Tau is not necessary for amyloid-β–induced synaptic and memory impairments
Authors: Daniela Puzzo, Elentina K. Argyrousi, Agnieszka Staniszewski, Hong Zhang, Elisa Calcagno, Elisa Zuccarello, Erica Acquarone, Mauro Fa’, Domenica D. Li Puma, Claudio Grassi, Luciano D’Adamio, Nicholas M. Kanaan, Paul E. Fraser, Ottavio Arancio
Journal: Journal of Clinical Investigation (2020)

The amyloid hypothesis posits that the amyloid-beta (Aβ) protein precedes and requires microtubule-associated protein tau in a sort of trigger-bullet mechanism leading to Alzheimer's disease (AD) pathology. This sequence of events has become dogmatic in the AD field and is used to explain clinical trial failures due to a late start of the intervention when Aβ already activated tau. Here, using a multidisciplinary approach combining molecular biological, biochemical, histopathological, electrophysiological, and behavioral methods, we demonstrated that tau suppression did not protect against Aβ-induced damage of long-term synaptic plasticity and memory, or from amyloid deposition. Tau suppression could even unravel a defect in basal synaptic transmission in a mouse model of amyloid deposition. Similarly, tau suppression did not protect against exogenous oligomeric tau-induced impairment of long-term synaptic plasticity and memory. The protective effect of tau suppression was, in turn, confined to short-term plasticity and memory. Taken together, our data suggest that therapies downstream of Aβ and tau together are more suitable to combat AD than therapies against one or the other alone.
Diagnostic Assessment of Lower Urinary Tract Symptoms in Men Considering Prostate Surgery: A Noninferiority Randomised Controlled Trial of Urodynamics in 26 Hospitals
Authors: Marcus J. Drake, Amanda L. Lewis, Grace J. Young, Paul Abrams, Peter S. Blair, Christopher Chapple, Cathryn M.A. Glazener, Jeremy Horwood, John S. McGrath, Sian Noble, Gordon T. Taylor, J. Athene Lane
Journal: European Urology (2020)
Total volume/week of physical activity: an underused variable of physical activity in daily life in patients with copd and its association with exercise capacity
Authors: Lorena P. Schneider, Felipe V.C. Machado, Antenor Rodrigues, Raquel P. Hirata, Daniele C. Dala Pola, Mariana P. Bertoche, Letícia F. Belo, Ana Carolina dos Reis Andrello, Jéssica Fonseca, Leandro C. Mantoani, Karina C. Furlanetto, Fabio Pitta
Journal: Pulmonology (2020)
Pulse Pressure and Isolated Diastolic Hypertension—Reply
Authors: John W. McEvoy, Elizabeth Selvin
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nature‐Inspired Adhesive Catecholamines for Highly Concentrated Colorimetric Signal in Spatial Biomarker Labeling
Authors: Seunghwi Kim, Seonki Hong
Journal: Advanced Healthcare Materials (2020)

Abstract Colorants have been utilized for precise biomarker detection in rapid and convenient colorimetric bioassays. However, the diffusion of colorants in solution often results in poor sensitivity, which is a major obstacle to the clinical translation of current colorants. To address this issue, in the current study, a unique colorant is developed that possesses adhesiveness for concentration near the target biomarker, avoiding diffusion. In nature, the synergistic interplay between catechol and amine functional groups is thought to be key for the unique mechanism of marine mussel adhesion. In addition, polymerized catecholamines are found in nature as biopigments, that is, in melanin. The dual role of catechol/catecholamine moieties in natural organics inspire to design novel colorimetric bioassays based on an adhesive colorant. Horseradish peroxidase (HRP) is used to initiate in situ polymerization of the catecholic precursors with amine‐containing additive molecules and simultaneously attach them near the HRP‐labeled biomarkers. This novel catecholamine‐based adhesive colorant provides an excellent quantitative (naked‐eye) visible signal and it also generates superb spatial information on the biomarkers on complex surfaces (e.g., cell membranes).
Exposure to waste sites and their impact on health: a panel and geospatial analysis of nationally representative data from South Africa, 2008–2015
Authors: Andrew Tomita, Diego F Cuadros, Jonathan K Burns, Frank Tanser, Rob Slotow
Journal: The Lancet Planetary Health (2020)

BackgroundRapid population growth, urbanisation, and economic development have led to an unprecedented number of waste sites in developing countries. This challenge has become a contentious international relations issue, with an unsustainable amount of waste and its health consequences often being borne by developing countries. However, little national-level evidence is available in sub-Saharan Africa to quantify the association between exposure to waste sites and health.MethodsWe used panel data from the South African National Income Dynamics Study (SA-NIDS) to investigate the association between exposure to waste sites and asthma, tuberculosis, diabetes, and depression. The SA-NIDS is a panel survey of a nationally representative sample in South Africa, which includes data reporting the health status of 32 255 individuals between 2008 and 2015. The study exposure was distance of households, in km, to the nearest waste site, derived from waste site geospatial locations from the South Africa Waste Information System.FindingsWe observed a substantial increase in exposure of households to waste sites between 2008 and 2015. The median distance between study households and waste sites decreased from 68·3 km (IQR 31·1–111·7) to 8·5 km (3·0–23·7). Residing within 5 km of a waste site was significantly associated with asthma (adjusted relative risk 1·41; 95% CI 1·20–1·64), tuberculosis (1·18; 1·02–1·36), diabetes (1·25; 1·05–1·49), and depression (1·08; 1·03–1·14). The association persisted even after controlling for multiple socioeconomic factors.InterpretationWe identified multiple adverse health outcomes in individuals living close to waste sites at a national level in South Africa, suggesting the need to reduce the number and size of waste sites to diminish harmful effects on health and wellbeing for communities living in close proximity to such sites.FundingSouth African Medical Research Council, South African National Treasury, and Wellcome Trust.
Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion
Authors: Rui Su, Lei Dong, Yangchan Li, Min Gao, Li Han, Mark Wunderlich, Xiaolan Deng, Hongzhi Li, Yue Huang, Lei Gao, Chenying Li, Zhicong Zhao, Sean Robinson, Brandon Tan, Ying Qing, Xi Qin, Emily Prince, Jun Xie, Hanjun Qin, Wei Li, Chao Shen, Jie Sun, Prakash Kulkarni, Hengyou Weng, Huilin Huang, Zhenhua Chen, Bin Zhang, Xiwei Wu, Mark J. Olsen, Markus Müschen, Guido Marcucci, Ravi Salgia, Ling Li, Amir T. Fathi, Zejuan Li, James C. Mulloy, Minjie Wei, David Horne, Jianjun Chen
Journal: Cancer Cell (2020)
Doctor–patient relationship at the time of COVID-19: travel notes
Authors: Fabrizio Vallelonga, Fabrizio Elia
Journal: Intensive Care Medicine (2020)

Protect yourself.Perform hand hygiene.Don your gloves and gown.Do not fear proximity to the patients when you are protected.Put your hand on the shoulder of your patients during rounds.Small actions are important.Actions speak louder than words.Protect yourself again.Don your mask and face shield.Look into the eyes of the patients during your visit.The mask may cover your face, but your eyes are unveiled.Show the patients you really do see them.Introduce yourself.Explain who you are, your role and share your medical plan.Write your name on your personal protective equipment.Behind a mask, a gown and a face shield, we are all the same in the eyes of a fearful patient.Make your connection personal.Make good use of time.Then spend some time listening to the patients.The time constraints of a disaster should not be an excuse for not hearing their needs.Listening time is care time.Make the best of the space you have.Describe the place and their situation to your patients.Preserve their privacy if you can.Enable mobility when possible.Many patients have restricted space and are close yet isolated.Common spaces can be sharing spaces.Recognize the identity of your patients.See beyond the clinical and laboratory parameters.Learn their life story, their relationships and how they deal with disease.The disease may be similar, but each patient is unique.Cure the disease, but take care of the person.Keep patients in touch with their families.Ensure family members are always updated.Take full advantage of the technology at your disposal.The disease can be one of loneliness and isolation.Prevent this by being the bridge between the patients and their loved ones.Embrace uncertainty.Uncertainty is inherent to our profession.Explain this to your patients and their families.Uncertainty is also a fundamental part of life and of disease.About COVID-19 we may know less, but we do not care less.With uncertainty comes hope.Accept the fear.Accept patients' fear of failing to recover and doctors' fear of failing to cure.Acknowledge the fear of dying alone.In disease and death fear makes us all equal.We are all human and that is the only thing that matters.Prevent unnecessary suffering.Involve psychologists, palliative care specialists and anyone who can help.Dyspnea can be worse than pain.Make patients' death as dignified as possible.They deserve no less and so do you. Compliance with ethical standards
Bioactive MOFs Based Theranostic Agent for Highly Effective Combination of Multimodal Imaging and Chemo‐Phototherapy
Authors: Yuda Zhu, Nini Xin, Zi Qiao, Suping Chen, Lingwan Zeng, Yusheng Zhang, Dan Wei, Jing Sun, Hongsong Fan
Journal: Advanced Healthcare Materials (2020)

Bioactive metal-organic frameworks (bio-MOFs) built from biofunctional metal ions and linkers show a new strategy to construct multifunctional theranostic platforms. Herein, a bio-MOF is synthetized via the self-assembling of Fe3+ ions and doxorubicin hydrochloride (DOX) molecules. Then, through a stepwise assembly strategy, another bio-MOFs structure consisting of Gd3+ ions and 1,3,5-benzenetricarboxylic acid (H3 BTC) is wrapped on the surfaces of Fe-DOX nanoparticles, followed by adsorbing photosensitizer indocyanine green (ICG). Specifically, the Gd-MOF shell structure can not only act as a contrast agent for magnetic resonance imaging (MRI), but also provides protection for Fe-DOX cores, controlling the release of DOX. The photoacoustic and photothermal imaging (PAI and PTI) methods are successfully introduced to the platform by loading ICG, providing potential applications for multimodal biological imaging. The in vitro and in vivo outcomes indicate that the Fe-DOX@Gd-MOF-ICG nanoplatform exhibits outstanding synergistic antitumor performance via MR/PA/PT imaging guided chemotherapy, photothermal and photodynamic combination therapy. The work may encourage further exploration of bio-MOFs based multifunctional theranostic platforms for multimodal imaging guided compound antitumor therapy, which will open an avenue of MOFs toward biological applications.
Gap junction-mediated cell-to-cell communication in oral development and oral diseases: a concise review of research progress
Authors: Wenjing Liu, Yujia Cui, Jieya Wei, Jianxun Sun, Liwei Zheng, Jing Xie
Journal: International Journal of Oral Science (2020)

Abstract Homoeostasis depends on the close connection and intimate molecular exchange between extracellular, intracellular and intercellular networks. Intercellular communication is largely mediated by gap junctions (GJs), a type of specialized membrane contact composed of variable number of channels that enable direct communication between cells by allowing small molecules to pass directly into the cytoplasm of neighbouring cells. Although considerable evidence indicates that gap junctions contribute to the functions of many organs, such as the bone, intestine, kidney, heart, brain and nerve, less is known about their role in oral development and disease. In this review, the current progress in understanding the background of connexins and the functions of gap junctions in oral development and diseases is discussed. The homoeostasis of tooth and periodontal tissues, normal tooth and maxillofacial development, saliva secretion and the integrity of the oral mucosa depend on the proper function of gap junctions. Knowledge of this pattern of cell–cell communication is required for a better understanding of oral diseases. With the ever-increasing understanding of connexins in oral diseases, therapeutic strategies could be developed to target these membrane channels in various oral diseases and maxillofacial dysplasia.
Abstract 13211: Prognostic Significance of Physical Trigger Type in Takotsubo Cardiomyopathy
Authors: Kathryn Cardoza, Arash Nayeri, Alexander Yuen, Andrea MacDonald, Cher Huang, Gregg C Fonarow, Quinn Wells, Kamran Shamsa
Journal: Circulation (2019)

Introduction: While traditionally described as a relatively benign condition, takotsubo cardiomyopathy (TC) has similar rates of short-term morbidity and mortality as acute coronary syndrome. Physi...
Prescription of macrolides vs penicillin during pregnancy was linked to major malformations in offspring
Authors: Jonathan Zipursky
Journal: Annals of Internal Medicine (2020)

Fan H, Gilbert R, O'Callaghan F, Li L. Associations between macrolide antibiotics prescribing during pregnancy and adverse child outcomes in the UK: population based cohort study. BMJ. 2020;368:m331. 32075790.
QuantiFERON‐TB Gold conversion is not uncommon in patients with psoriasis undergoing anti‐tumour necrosis factor‐α therapy
Authors: M. Megna, A. Ruggiero, M. Ferrillo, G. Fabbrocini
Journal: British Journal of Dermatology (2020)

Linked Article: Ya et al. Br J Dermatol 2020; 182:800–802.
Bioengineering tools to speed up the discovery and preclinical testing of vaccines for SARS-CoV-2 and therapeutic agents for COVID-19
Authors: Manuela Teresa Raimondi, Francesca Donnaloja, Bianca Barzaghini, Alberto Bocconi, Claudio Conci, Valentina Parodi, Emanuela Jacchetti, Stephana Carelli
Journal: Theranostics (2020)

This review provides an update for the international research community on the cell modeling tools that could accelerate the understanding of SARS-CoV-2 infection mechanisms and could thus speed up the development of vaccines and therapeutic agents against COVID-19.Many bioengineering groups are actively developing frontier tools that are capable of providing realistic three-dimensional (3D) models for biological research, including cell culture scaffolds, microfluidic chambers for the culture of tissue equivalents and organoids, and implantable windows for intravital imaging.Here, we review the most innovative study models based on these bioengineering tools in the context of virology and vaccinology.To make it easier for scientists working on SARS-CoV-2 to identify and apply specific tools, we discuss how they could accelerate the discovery and preclinical development of antiviral drugs and vaccines, compared to conventional models.
Unilateral proptosis in Lemierre's syndrome variant
Authors: Meng-Fang Shen, Hung-Jen Chen
Journal: Thorax (2020)

The transcription factor nuclear factor-erythroid 2-related-2 (Nrf2) controls cellular redox homeostasis and displays immunomodulatory properties. Hypoxic microenvironment in solid tumors generated by their outgrowth activates Nrf2 which induces the expression of anti-oxidant genes and supports continuous growth and proliferation via metabolic reprogramming. It is easy to imagine that hypoxic situation may affect function of immune cells infiltrated into tumor mass. We have thus questioned how hypoxic condition affect T cell immune response against tumor and the role of Nrf2 is involved. First, tumor infiltrating T cells (TILs) were sorted from tumor mass to investigate the alteration of Nrf2 expression. Interestingly, we found that mRNA levels of Nrf2 are significantly increased in TILs compared to control T cells. In order to test whether T cell responses are affected by Nrf2 levels, we stimulated T cells and measured Nrf2 expression. Nrf2 expression and their target genes are significantly downregulated by TCR activation. We further confirmed that IFN-γ production in Nrf2 deficient T cells was dramatically enhanced. Our findings offer novel insights into how immune response and oxidative stress is integrated in tumor cells, and we highlight Nrf2 as candidate of molecular target to control tumor in hypoxic condition.