tbuckley/cabot-search huggingface dataset:
Abstract 105: Transferring Images via the Wireless Messaging Network using Camera Phones Shortens Time Required to Diagnose Acute Coronary Syndrome
Authors: Masashi Ohtsuka, Eiji Uchida, Toru Nakajima, Hiroyuki Yamaguchi, Hiroyuki Takano, Issei Komuro
Journal: Circulation (2007)

The speed at which reperfusion treatment can begin is critical in cases of acute coronary syndrome. Electrocardiograms (ECG) are used to make the diagnosis. In the absence of a cardiologist in the emergency room (ER), the ECG image data must be sent to a cardiologist on stand-by outside the hospital. Up until now, ECG images were sent from the hospital to the cardiologist by fax, but if a fax machine is not readily available to the cardiologist, they must look for one in order to receive the image data. More recently, camera phones have become very advanced and are able to send and receive high quality images by e-mail. In this study, we examined whether sending ECG images to a cardiologist by camera phone was more efficient than by fax. ECG images were taken of 20 patients suspected to have acute coronary syndrome. Patients were divided alternately into two groups of ten patients each; the F group and the CP group. The F group’s ECG images were sent to a cardiologist by fax (n=10) and the CP group’s ECG images were sent by camera phone (n=10). We measured the time taken in transmitting the images from the ER to a cardiologist, the time taken to analyze that image and the total time elapsed from image transmission to diagnosis by the cardiologist. All data presented are mean±SD. Group comparisons were based on the Student’s t-test. The amount of time taken in transmitting the images from the ER to the cardiologist was longer in the F group (163.8±5.1 sec) than that taken by the CP group (71.5±4.6 sec). However, the amount of time taken by the cardiologist to analyze those images was shorter in the F group (12.9±1.8 sec) than that of the CP group (24.1±4.3 sec). Total time elapsed from image transmission to diagnosis was shorter in the CP group (95.6 ± 8.4 sec) than that of the F group (176.7 ± 4.9 sec). In conclusion, using camera phones to transmit ECG images to the cardiologist shortens the time taken to diagnose acute coronary syndrome. Furthermore, camera phones are more advantageous in regards to availability and cost in comparison to fax machines because of the recent popularization of camera phones. Therefore, image transmission by camera phones is more efficient in sending image data to a cardiologist than by fax.
Apport de la coagulation au plasma argon dans le traitement des rectites radiques: expérience d'un service marocain
Authors: S Ouahid, T Addajou, S Berrag, Y Azali, M Fidèle, L Ndayikeza, S Jamal, M Tamzaourte, A Aourarh
Journal: Endoscopy (2019)

L'APC est une méthode d'hémostase endoscopique récente qui a connu un essor sans précédent depuis son apparition en 1991. Elle permet la réalisation d'une électrocoagulation monopolaire sans contact avec la muqueuse traitée par le biais d'un gaz inerte, incolore, non inflammable et non toxique. Le but de notre travail était d'évaluer l'intérêt de l'APC dans la prise en charge endoscopique de l'hémorragie digestive survenant au cours des rectites radiques chroniques hémorragiques.
CLINICAL OUTCOMES OF PALLIATIVE COLORECTAL SELF-EXPANDABLE METAL STENT PLACEMENT: RESULTS OF A TWO-CENTER RETROSPECTIVE STUDY
Authors: O Yun, A Fedorov, S Davydova, A Klimov
Journal: Endoscopy (2019)

Self-expandable metal stent placement is an established method of palliation for patients with malignant colorectal obstruction, but it can be challenging is cases of locally advanced cancer. The aim of the study was to evaluate early and long-term outcomes of palliative colorectal stenting.
PERFORMANCE OF EUS-GUIDED TISSUE ACQUISITION IN SAMPLING OF GI SUBEPITHELIAL LESIONS
Authors: M Di Leo, F Auriemma, E Stasi, L Lamonaca, F Cananzi, D Rahal, P Bossi, A Fugazza, A Anderloni, P Colombo, R Maselli, PA Galtieri, EC Ferrara, V Quagliuolo, A Repici, S Carrara
Journal: Endoscopy (2019)

The pathological diagnosis of gastrointestinal subepithelial lesions (SELs) is fundamental to guide management decisions. EUS guided tissue acquisition (EUS-TA) is crucial technique to reach the final pathological diagnosis. Different types of needles have been developed to perform fine needle biopsy (FNB) in order to overcome the limitations of standard fine-needle aspiration (FNA).
Phagocytosis-shielded lentiviral vectors improve liver gene therapy in nonhuman primates
Authors: Michela Milani, Andrea Annoni, Federica Moalli, Tongyao Liu, Daniela Cesana, Andrea Calabria, Sara Bartolaccini, Mauro Biffi, Fabio Russo, Ilaria Visigalli, Andrea Raimondi, Susannah Patarroyo-White, Douglas Drager, Patrizia Cristofori, Eduard Ayuso, Eugenio Montini, Robert Peters, Matteo Iannacone, Alessio Cantore, Luigi Naldini
Journal: Science Translational Medicine (2019)

Lentiviral vectors with high surface content of CD47 improved gene transfer efficiency to hepatocytes in nonhuman primates.
Neurological Consequences of Cytokine Release Syndrome Following Subcutaneous Recombinant IL-15 and Haploidentical Donor Natural Killer Cell Therapy for Advanced Acute Myeloid Leukemia
Authors: Sarah Cooley, Fiona He, Veronika Bachanova, Greg M Vercellotti, Todd E. DeFor, Julie Curtsinger, Paul Alexander Robertson, Kevin C Conlon, Thomas A Waldmann, David H. McKenna, Bruce Blazar, Daniel J. Weisdorf, Jeffrey S. Miller
Journal: Blood (2017)
Abstract 1794: The FES-related tyrosine kinase associates with and activates the insulin-like growth factor 1 receptor at sites of cell adhesion
Authors: Joanna Stanicka, Leonie Rieger, Orla T. Cox, Sandra O'Shea, Michael Coleman, Ciara O'Flanagan, Barbara Addario, Nuala McCabe, Richard Kennedy, Rosemary O'Connor
Journal: Cancer Research (2018)

Abstract Insulin-like Growth Factor-1 signaling has a well-described function in facilitating tumourigenesis and promoting tumour growth. Attempts to suppress IGF signals at the level of the IGF-1 Receptor have been disappointing, with kinase inhibitors and blocking antibodies generally showing poor efficacy in clinical trials. To address the mechanisms for this lack of efficacy we sought to identify proteins that modulate the cytotoxic response to IGF-1R tyrosine kinase inhibition using a functional siRNA screen. We identified the non-receptor tyrosine FES-related (FER) kinase as a mediator of sensitivity to the IGF-1R tyrosine kinase inhibitor in MCF-7 cells. We found that FER and the IGF-1R co-locate and can be co-immunoprecipitated from different cell types. Ectopic expression of FER strongly enhanced IGF-1R expression and phosphorylation on the atuophosphorylation sites at tyrosines 950 and 1131. FER phosphorylated these sites in an IGF-1R kinase-independent manner and also enhanced IGF-1-mediated phosphorylation of SHC, and activation of either the AKT or MAPK signaling pathways in breast cancer cell lines. The IGF-1R, β1 Integrin, FER and its substrate cortactin were all observed to be co-located in cell adhesion complexes, the disruption of which reduced IGF-1R expression and activity. High FER expression correlates with phosphorylation of SHC in breast cancer cell lines and with a poor prognosis in patient cohorts. FER and SHC phosphorylation and IGF-1R expression could be suppressed with a known ALK inhibitor that shows high specificity for FER kinase. Overall, we conclude that FER-enhances IGF-1R expression, phosphorylation and signaling to promote cooperative growth and adhesion signaling that may facilitate cancer progression and resistance to IGF-1R inhibition. Citation Format: Joanna Stanicka, Leonie Rieger, Orla T. Cox, Sandra O'Shea, Michael Coleman, Ciara O'Flanagan, Barbara Addario, Nuala McCabe, Richard Kennedy, Rosemary O'Connor. The FES-related tyrosine kinase associates with and activates the insulin-like growth factor 1 receptor at sites of cell adhesion [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 1794.
Sustained virologic response to direct-acting antiviral therapy in patients with chronic hepatitis C and hepatocellular carcinoma: A systematic review and meta-analysis
Authors: Fanpu Ji, Yee Hui Yeo, Mike Tzuhen Wei, Eiichi Ogawa, Masaru Enomoto, Dong Hyun Lee, Etsuko Iio, John Lubel, Wenjun Wang, Bin Wei, Tatsuya Ide, Carmen Monica Preda, Fabio Conti, Tatsuya Minami, Rob Bielen, Hitomi Sezaki, Michele Barone, Philippe Kolly, Po-sung Chu, Victor Virlogeux, Dennis Eurich, Linda Henry, Michelle B. Bass, Takanori Kanai, Shuangsuo Dang, Zongfang Li, Jean-François Dufour, Fabien Zoulim, Pietro Andreone, Ramsey C. Cheung, Yasuhito Tanaka, Norihiro Furusyo, Hidenori Toyoda, Akihiro Tamori, Mindie H. Nguyen
Journal: Journal of Hepatology (2019)
Abstract 15677: Facilitated Transmembrane Transport of Nitric Oxide in Endothelial Cells
Authors: Shiow-Shih Tang, Joseph Loscalzo
Journal: Circulation (2011)

Nitric oxide (NO) is a key endothelial cell (EC) signaling molecule that exerts its actions both within the EC and within heterologous target cells. It has been assumed that NO traverses the plasma membrane of the EC by simple diffusion owing to its relative lipophilicity, and that, in addition, aquaporin 1 (AQP1) facilitates NO transport. In this report, we employed other eNOS activators to rule out the membrane effect of A23187. We measured NO efflux by assaying NO released into the media by nitrite/nitrate determination, correcting for the fraction that was inhibited by L-NAME. To activate eNOS (without the membrane disruption accompanying calcium ionophore), we used acetylcholine (Ach) at 3x10 -4  M, methacholine (Mch) at 3x10 -4  M, serotonin (5HT) at 3x10 -4  M, bradykinin (BK) at 3x10 -5  M, substance P (SP) at 3x10 -5  M, and 1.5 mM ATP. We found that none of them alone can induce detectable nitrite level over 6 hours of incubation. However, a combination of 3x10 -5  M BK and 1.5 mM ATP generated 0.94 ± 0.44 nmol NO/mg protein/6 hrs. Given these results, we next used the combination of BK and ATP was used to induce NO efflux in bovine aortic ECs in order to assess the role of selected transporters in facilitating NO release. We knocked down AQP1, Glut 2 (facilitated glucose transporter 1), or UTB1 (urea transporter B1) with siRNA to each, and found that NO effluxes were 0.09 ± 0.14, 0.18 ± 0.29, and 0.22 ± 0.34 nmoles/mg protein/6 hrs, respectively, whereas SGLT1 (sodium-dependent glucose transporter 1), SGLT2, siRNA scrambled sequence, and buffer control were 0.81 ± 0.78, 0.54 ± 0.70, 0.68 ± 0.63, and 0.99 ± 0.17 nmoles/mg protein/6 hrs, respectively. Nitric oxide efflux at one hour was increased ~ 2-fold by overexpression of SGLT2 and UTB1 in BAECs, as compared to control. These results demonstrate that AQP1, Glut 2, and UTB1 play a role in NO flux in ECs, and suggest that the transfer of NO across the EC plasma membrane can be facilitated via specific membrane channel-dependent mechanisms.
COMPARISON OF THE THERMAL ARTEFACT BETWEEN EMR AND UNDERWATER-EMR AND IT'S INFLUENCE IN THE HISTOLOGICAL ASSESSMENT
Authors: M Sánchez Alonso, L González López, M Cuatrecasas, J Rodríguez Sánchez
Journal: Endoscopy (2019)

Thermal artefact in endoscopic mucosal resection (EMR) specimens, suppose one of the main drawbacks in the pathologic assessment. Heat dissipation effect endorsed by underwater-EMR might lead a way to prevent this handicap. We aimed to compare the thermal artefact in samples of en-bloc resection perfomed by EMR and Underwater EMR. In this regard, injuries in margins and in the whole samples were cautious assessed.
Maladie de Crohn: apport de l'endoscopie digestive haute et de l'anatomopathologie
Authors: D Issaoui, C Baccouche, K Chabbouh, H Kchir, H Chaabouni, N Maamouri
Journal: Endoscopy (2019)

La maladie de Crohn (MC) est une pathologie inflammatoire chronique pouvant atteindre tout le tube digestif, de la bouche à l'anus. La fibroscopie oesogastroduodénale (FOGD) avec réalisation de biopsies étagées permet de rechercher des localisations hautes de la maladie. Ce travail a pour objectif d'étudier l'intérêt de la FOGD avec étude anatomopathologique dans la détection des localisations hautes de la MC.
FACTORS OF PREOPERATIVE COLONOSCOPY THAT AFFECT THE DETECTION OF SYNCHRONOUS ADENOMA IN COLORECTAL CANCER PATIENTS
Authors: JH Park, HS Moon, JS Kim, SH Kang, JK Sung, HY Jeong
Journal: Endoscopy (2019)

Despite thorough preoperative screening, approximately 19 – 30% of synchronous polyps are detected after colon cancer surgery. Remnant synchronous lesions might require additional colonoscopy procedure or surgery. The purpose of this study was to investigate the factors of preoperative colonoscopy that can affect the detection of synchronous lesions in the colon in patients who have undergone surgery for colorectal cancer.
Paul Godley: oncologist, epidemiologist, researcher, and photographer
Authors: Rebecca Wallersteiner
Journal: BMJ (2019)

Credit: University of North Carolina

Paul Alphonso Godley was born in Detroit, Michigan, in the US, the son of Alegro J Godley, an internist, and his wife, Juanita, a nurse. He grew up in a home where medicine was discussed every day. The studious young Godley was educated at the Friends School in Detroit, where he excelled at science and developed a love for music and the visual arts. While Godley was working towards his MD, his mother died from colon cancer, influencing his choice of specialty and sparking an ongoing research interest in cancer prevention. He became a world class oncologist and cancer researcher, and a professor in the department of medicine at the University of North Carolina (UCN) at Chapel Hill School of Medicine—the first African-American to do so. He dedicated his life to compassionate care for patients with prostate cancer.

He married Adaora Adimora, an infectious disease physician, who also became an epidemiologist. He was a devoted husband and loving father. An adventurous traveller, he visited six continents with his family, and it was through his travels that he honed his passion for photography.

“Paul was friendly and had a great sense of humour; but he was not loquacious, and chose his words carefully, which, along with his demeanour, gave them that much more weight in …
Abstract 11211: CTCF and HMGA1 Opposite Directionally Regulate the Gene Expression of microRNAs at Scaffold/ Matrix-attachment Regions in the Arterial Smooth Muscle Cell
Authors: Kunimitsu Iwai, Takuro Morita, Osamu Iritani, Shigeto Morimoto, Yuka Nakamura, Yasuhito Ishigaki
Journal: Circulation (2013)

Purpose: Although specific microRNAs (miRNAs) critically regulate the phenotypic modulation of arterial smooth muscle cell (SMC), the mechanism of their gene expression is unknown. The nuclear matr...
Abstract 18002: Novel Mechanisms for Exercise Induced Improved Vasodilation and Angiogenesis in Diabetes: Role of Extracellular SOD-Derived H2O2
Authors: Sudhahar Varadarajan, Ken S Lizama, Erika Oji, Mohamed M Ali, Shane A Phillips, Masuko Ushio-Fukai, Tohru Fukai
Journal: Circulation (2017)

Background: Exercise has beneficial effects on endothelial dysfunction in pathological conditions such as diabetes mellitus (DM), but its underlying mechanisms are poorly understood. Evidence sugge...
ENDOSCOPIC ULTRASOUND-GUIDED FINE-NEEDLE ASPIRATION FOR PANCREATIC SOLID LESIONS: CYTOLOGY, HISTOLOGY OR BOTH?
Authors: M João, L Elvas, D Brito, S Alves, M Areia, F Taveira, S Saraiva, AT Cadime
Journal: Endoscopy (2019)

Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is the gold standard procedure for obtaining pathological diagnosis of pancreatic solid lesions. The specimen obtained by EUS-FNA can be prepared for either cytological or histological (cellblock) examinations. The aim of our study was to compare diagnostic accuracy of cytology, cellblock and both, in the absence of on-site pathologist.
SHORT- AND LONG-TERM OUTCOMES OF ENDOSCOPIC SUBMUCOSAL DISSECTION IN THE REMNANT STOMACH
Authors: K Nomura, S Hoteya, D Kikuchi, T Iizuka
Journal: Endoscopy (2019)

We evaluated the short- and long-term outcomes of endoscopic submucosal dissection (ESD) performed in the remnant stomach after gastrectomy or esophagectomy.
FACTORS ASSOCIATED WITH TECHNICAL SUCCESS IN COLONIC STENT PLACEMENT
Authors: I Couto, A Guerrero-Montañés, M López-Álvarez, L Yáñez-González-Dopeso, MT Seoane-Pillado, P Alonso-Aguirre
Journal: Endoscopy (2019)

Tab. 1: Multivariate analysis of factors associated with technical success in endoscopic stent placement Sig OR (CI 95%) Peritoneal carcinomatosis 0,025 0,309 (0,111 – 0,861) Expert endoscopist 0,003 3,935 (1,602 – 9,668)
Reprise endoscopique de cicatrice pour la prise en charge du cancer colorectal localisé: est-ce une alternative acceptable pour éviter une chirurgie après une première résection en marges microscopiques non saines? Série de cas monocentrique française
Authors: C Dassetto, JP Ratone, E Bories, F Caillol, C Pesenti, C De Chaisemartin, B Lelong, H Meillat, F Poizat, M Giovannini
Journal: Endoscopy (2019)

La résection endoscopique est habituellement le traitement de première ligne des adénomes et adénocarcinomes colorectaux. En cas d'histologie défavorable: invasion sous-muqueuse > pT1sm1 ou pT1sm1 avec des critères anatomopathologiques défavorables (peu différencié, embols vasculaires ou budding grade 2 – 3) une prise en charge chirurgicale est nécessaire en raison du risque d'envahissement ganglionnaire et cela malgré une résection complète (R0). En cas de résection microscopiquement incomplète (R1), une prise en charge chirurgicale demeure le gold-standard actuel car le risque d'envahissement ganglionnaire est inconnu. Dans l'objectif d'éviter des chirurgies non nécessaires nous avons évalué l'efficacité et la sécurité d'une reprise endoscopique pour compléter la résection chez des patients sélectionnés et en accord avec l'équipe chirurgicale de notre centre. En effet, si pour beaucoup de médecins cette approche paraît être une option thérapeutique acceptable, peu d'études ont été réalisées sur le sujet. La reprise endoscopique est une méthode sûre et efficace (mais moins) après une résection macroscopiquement incomplète (R2) et nous voulions démontrer dans notre série de cas l'intérêt d'une reprise endoscopique de la cicatrice pour des résection R1.
ENDOSCOPIC PAPILLARY AND BILIARY LARGE BALLOON DILATION IS SAFE AND EFFECTIVE FOR DIFFICULT STONES REMOVAL IN PATIENTS WITH NONDILATED OR TAPERED DISTAL BILE DUCT
Authors: J Pereira Lima, G Pereira Lima, I Contin, ID Arciniegas, C Saul, CE Oliveira dos Santos
Journal: Endoscopy (2019)

According to guidelines, papillary/biliary balloon dilation (PBBD) should not exceed the maximum diameter of the distal bile duct and should not be performed in cases of nondilated distal bile duct. So, the use of papillary/biliary balloon dilation is contraindicated in patients with nondilated or tapered distal bile duct, in whom there is disproportion between the size of the stone and the distal bile duct. In this series, we analyze the feasibility of balloon dilation for difficult stones (> 1 cm, impacted or multiple) in patients with a narrow distal bile duct.
GASTRIC ADENOCARCINOMA UNDER THE AGE OF 60: A MULTICENTRIC STUDY FROM SOUTHERN EUROPE
Authors: E Rodríguez de Santiago, N Hernanz, HM Marcos-Prieto, MÁ Jorge-Turrión, E Barreiro-Alonso, C Rodríguez-Escaja, A Jiménez-Jurado, N Machado-Volpato, I Pérez-Valle, M García-Prada, M Sierra-Morales, R Ríos León, AG García de Paredes, A Castaño-García, J Ramón Foruny-Olcina, JÁ González Martín, B Peñas-García, E Vázquez-Sequeiros, A Albillos
Journal: Endoscopy (2019)

In Europe, gastric adenocarcinoma (GC) is commonly regarded as a disease of the elderly. This study aims to assess the proportion, characteristics, and survival of patients diagnosed with GC under the age of 60.
Only α‐Gal bound to lipids, but not to proteins, is transported across enterocytes as an IgE‐reactive molecule that can induce effector cell activation
Authors: Patricia Román‐Carrasco, Barbara Lieder, Veronika Somoza, Marta Ponce, Zsolt Szépfalusi, Diana Martin, Wolfgang Hemmer, Ines Swoboda
Journal: Allergy (2019)

The oligosaccharide galactose-α-1,3-galactose (α-Gal), present in mammalian proteins and lipids, causes an unusual delayed allergic reaction 3 to 6 hours after ingestion of mammalian meat in individuals with IgE antibodies against α-Gal. To better understand the delayed onset of allergic symptoms and investigate whether protein-bound or lipid-bound α-Gal causes these symptoms, we analyzed the capacity of α-Gal conjugated proteins and lipids to cross a monolayer of intestinal cells.Extracts of proteins and lipids from beef were prepared, subjected to in vitro digestions, and added to Caco-2 cells grown on permeable supports. The presence of α-Gal in the basolateral medium was investigated by immunoblotting, thin-layer chromatography with immunostaining and ELISA, and its allergenic activity was analyzed in a basophil activation test.After addition of beef proteins to the apical side of Caco-2 cells, α-Gal containing peptides were not detected in the basolateral medium. Those peptides that crossed the Caco-2 monolayer did not activate basophils from an α-Gal allergic patient. Instead, when Caco-2 cells were incubated with lipids extracted from beef, α-Gal was detected in the basolateral medium. Furthermore, these α-Gal lipids were able to activate the basophils of an α-Gal allergic patient in a dose-dependent manner.Only α-Gal bound to lipids, but not to proteins, is able to cross the intestinal monolayer and trigger an allergic reaction. This suggests that the slower digestion and absorption of lipids might be responsible for the unusual delayed allergic reactions in α-Gal allergic patients and identifies glycolipids as potential allergenic molecules.
mRNA Delivery for Therapeutic Anti-HER2 Antibody Expression In Vivo
Authors: Yulia Rybakova, Piotr S. Kowalski, Yuxuan Huang, John T. Gonzalez, Michael W. Heartlein, Frank DeRosa, Derfogail Delcassian, Daniel G. Anderson
Journal: Molecular Therapy (2019)

Antibody-based drugs are a leading class of biologics used to treat a variety of diseases, including cancer. However, wide antibody implementation is hindered by manufacturing challenges and high production cost. Use of in-vitro-transcribed mRNA (IVT-mRNA) for endogenous protein expression has the potential to circumvent many of the shortcomings of antibody production and therapeutic application. Here, we describe the development of an IVT-mRNA system for in vivo delivery of a humanized anti-HER2 (also known as ERBB2) antibody, trastuzumab, and demonstrate its anticancer activity. We engineered the IVT-mRNA sequence to maximize expression, then formulated the IVT-mRNA into lipid-based nanoparticles (LNPs) to protect the mRNA from degradation and enable efficient in vivo delivery. Systemic delivery of the optimized IVT-mRNA loaded into LNPs resulted in antibody serum concentrations of 45 ± 8.6 μg/mL for 14 days after LNP injection. Further studies demonstrated an improved pharmacokinetic profile of the produced protein compared to injection of trastuzumab protein. Finally, treatment of tumor-bearing mice with trastuzumab IVT-mRNA LNPs selectively reduced the volume of HER2-positive tumors and improved animal survival. Taken together, the results of our study demonstrate that using IVT-mRNA LNPs to express full-size therapeutic antibodies in the liver can provide an effective strategy for cancer treatment and offers an alternative to protein administration.