tbuckley/cabot-search huggingface dataset:
Hippo Pathway in Cancer: Aberrant Regulation and Therapeutic Opportunities
Authors: Philamer C. Calses, James J. Crawford, Jennie R. Lill, Anwesha Dey
Journal: Trends in cancer (2019)

The Hippo pathway remains a central focus in both basic and translational research and is a key modulator of developmental biology. Dysregulation of the pathway is associated with a plethora of human cancers and there are multiple efforts to target key components of the pathway for disease intervention. In this review, we briefly highlight the latest research advances around the core components of the Hippo pathway in cancer. More specifically, we discuss several genetic aberrations of these factors as mechanisms for the development of cancers, including genetic amplification, deletion, and gene fusions. Additionally, we highlight the role of the Hippo pathway in cancer therapy resistance and tumor immunogenicity. Last, we summarize the ongoing efforts to target the pathway in cancers.
Screening for Neonatal Hyperbilirubinemia—First Do No Harm?
Authors: Scott D. Grosse, Lisa A. Prosser, Jeffrey R. Botkin
Journal: JAMA Pediatrics (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Fucosyltransferase 2 induces lung epithelial fucosylation and exacerbates house dust mite–induced airway inflammation
Authors: Aiko Saku, Koichi Hirose, Takashi Ito, Arifumi Iwata, Takashi Sato, Hiroyuki Kaji, Tomohiro Tamachi, Akira Suto, Yoshiyuki Goto, Steven E. Domino, Hisashi Narimatsu, Hiroshi Kiyono, Hiroshi Nakajima
Journal: Journal of Allergy and Clinical Immunology (2019)
Abstract 14960: Trends and Outcomes of Surgical Aortic Valve Replacement in Patients With Liver Cirrhosis: Insight From the National Inpatient Sample
Authors: Ahmad Almustafa, Sami Aljohani, Fahad Alqahtani, Ali Hama Amin, Akram Kawsara, Mohamad Adnan Alkhouli
Journal: Circulation (2017)

Background: Patients with liver cirrhosis who undergo cardiac surgery are at increased risk of perioperative mortality and morbidity. Risk prediction tool does not factor in the presence of cirrhos...
EUS GUIDED BILIARY DRAINAGE – TECHNICAL VARIANTS
Authors: J Fernandes, M Moreira, T Araújo, S Giestas, H Ribeiro, F Lucas, D Libânio, J Ramada, M Certo, J Canena, L Lopes
Journal: Endoscopy (2019)

We present the video of 4 cases of obstructive jaundice solved with endoscopic ultrasonography guided biliary drainage. In 3 of these patients, it was not possible to access the second duodenal portion and/or to visualize the papilla major due to the presence of pancreatic head adenocarcinomas with subsequent duodenal invasion, which led to choledochoduodenostomies in two of them, and the placement of a anterograde transpapillar metal stent through the duodenal bulb in the other patient.
L'endoscopie digestive sous AG dans les centres hospitaliers généraux (CHG) en 2018: Etude descriptive de pratique ANGH dans 84 CHG
Authors: G Macaigne, RL Vitte, JP Arpurt, P Lahmek, V Quentin, I Rosa, S Nahon
Journal: Endoscopy (2019)

Les modalités d'organisation de l'endoscopie digestive sous AG (EDAG) dans les CHG paraissent très hétérogènes. Cette activité peut être localisée dans une unité dédiée d'endoscopie digestive, dans un bloc opératoire central ou dans un bloc ambulatoire polyvalent. Cette enquête «minute» a pour objectifs d'effectuer un état des lieux des pratiques de l'EDAG dans nos CHG.
Endocrine implications in male breast cancer in Bulgaria
Authors: A.A. Konsoulova-Kirova, K. Kalchev, A. Yordanov, S. El Shemeri, S.A. Strashilov, S.I. Maslyankov, K.G. Angelov, D. Kostova-Lefterova, Y. Marincheva, M.B. Vasileva
Journal: Annals of Oncology (2019)

Background: The vast majority of male breast cancers (male BC) are luminal-like hormone receptor (HR) positive invasive ductal carcinomas. Agter surgery, endocrine treatment (ET) therefore should be the mainstay in both adjuvant and metastatic setting. According to the RARECAREnet study, 5-year relative survival until 2007 in Bulgarian male BC patients is 59%, compared to 77% on average for Europe. We therefore analyze available data from the National Cancer Registry to identify reasons for these low survival rates and aim to assess the role of ET in the management of male BC patients in Bulgaria. Methods: This is a retrospective population based study of all 521 male BCs (520 patients, one had bilateral BC), diagnosed between 2002 and 2013 in Bulgaria. Data was collected from the National Cancer Registry. To compare trends in the use of ET, numbers were divided in two time intervals (2002-2007 and 2008 – 2013) and data about ET were recorded and analyzed. Results: Median age of all 243 patients, diagnosed in the period 2002-2007 was 65 years; for the 278 patients, diagnosed in 2008-2013 median age was 66.6 years. Data for hormone receptors (HR) were available in 118/243 (84.7%) male BCs for the first time interval and in 156/278 (80.8%) for the second. HR positivity (ER+ or ER/PR+) was considered as indication for endocrine treatment (ET), both adjuvant (ADJ) or in the metastatic setting. Data on HR positivity, M status and ET are shown in Table. Conclusions: As a rare disease, management of male BC is suboptimal in Bulgaria. Despite the fact that male BC is predominantly endocrine-responsive disease, in Bulgaria ET is still largely underused, both in the adjuvant and in the metastatic setting. Still, there is a clear trend towards an increase in the use of adjuvant ET, but unfortunately this is not seen in the metastatic setting. The underuse of ET might be one of the reasons for the shorter survival of Bulgarian male BC patients. We hope that identification of the problem after analysis of available data from the National Cancer registry, together with improvement of the knowledge about male BC might serve as first steps towards better management of this rare disease. Editorial acknowledgement: Minka Yordanova, Expert System Software and Database. Legal entity responsible for the study: Assia Konsoulova. Funding: Has not received any funding. Disclosure: All authors have declared no conflicts of interest. Table36P HR status and ETTime periodPatients with HR+HR+, cM0Adj ET, n/%HR+, cM1ET for metastatic disease, n/%2002-20071007010/14.3%3010/ 33.3%2008-20131269636/37.5%307/23.3% Open table in a new tab
ZD6474 Inhibits Vascular Endothelial Growth Factor Signaling and Growth of a Wide Range of Tumor Models Following Chronic Oral Administration
Authors: DJ Ogilvie, M Dukes, J Kendrew, R Chester, JA Jackson, SJ Boffey, PJ Valentine, JO Curwen, C Barnes, HL Musgrove, GA Graham, AP Thomas, Ese Stokes, B Curry, Ghp Richmond, PF Wadsworth, LF Hennequin
Journal: Cancer Research (2002)
L'endoscopie digestive d'astreinte: expérience d'un centre hospitalier général français
Authors: Y Thiyfa, T Gharbi, H Laarabi, L Kabbage, I Dadamessi
Journal: Endoscopy (2019)

Nous rapportons notre expérience de l'endoscopie digestive d'astreinte (EA) dans un centre hospitalier général (CHG) de 874 lits de MCO, l'unité d'endoscopie digestive est ouverte en semaine du lundi au vendredi de 8h à 16h. Une astreinte d'endoscopie est assuré en soirée de 18h à 8h et les week-end. L'endoscopie est faite par un senior d'astreinte de sécurité, un interne de spécialité et une équipe d'anesthésie au bloc opératoire.
HEREDITARY HEMORRHAGIC TELANGIECTASIA: DEMOGRAPHIC AND ENDOSCOPIC CHARACTERISTICS OF A LATIN AMERICAN COHORT
Authors: A Ramirez Polo, G Grajales Figueroa, R Barreto Zúñiga, F Valdovinos Andraca, LE Zamora Nava
Journal: Endoscopy (2019)

Primary: To describe the demographic characteristics and endoscopic findings of patients with HHT in a third-level center in Mexico. Secondary: To determine the number and type of endoscopic studies and treatment used.
Abstract 16516: Sustained LDL-C Lowering and Stable Hepatic Fat Levels in Patients With Homozygous Familial Hypercholesterolemia Treated With the Microsomal Triglyceride Transfer Protein Inhibitor, Lomitapide: Results of an Ongoing Long-Term Extension Study
Authors: Marina Cuchel, Dirk J Blom, Maurizio R Averna, Emma A Meagher, Hendrik D Theron, Cesare R Sirtori, Robert A Hegele, Prediman K Shah, Daniel Gaudet, Claudia Stefanutti, Giovanni B Vigna, LeAnne T Bloedon, Daniel J Rader, HoFH Lomitapide Study Investigators
Journal: Circulation (2013)

Background: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disease characterized by markedly elevated LDL-C and high CVD risk. Lomitapide is approved in the US to lower LDL-C as ...
DIGESTIVE PERFORATIONS RELATED TO ENDOSCOPY PROCEDURES BEFORE AND AFTER ESGE GUIDELINES: A LOCAL MANAGEMENT CHARTER BASED ON LOCAL EVIDENCE AND EXPERTS OPINION
Authors: M Pioche, G Bertrand, J Rivory, JC Saurin, M Robert, PJ Valette, F Rostain, T Ponchon
Journal: Endoscopy (2019)

Perforations are a known side effect of endoscopic procedures. A proposal for appropriate management should be available in each center and shared with radiologists and surgeons as recommended by ESGE. The objective of our study was to analyze retrospectively the results of perforation management in our center before and after 2016, in order to create a management charter based on local evidence and opinion of local experts.
Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants
Authors: Bryan D. Smith, Michael D. Kaufman, Wei-Ping Lu, Anu Gupta, Cynthia B. Leary, Scott C. Wise, Thomas J. Rutkoski, Yu Mi Ahn, Gada Al-Ani, Stacie L. Bulfer, Timothy M. Caldwell, Lawrence Chun, Carol L. Ensinger, Molly M. Hood, Arin McKinley, William C. Patt, Rodrigo Ruiz-Soto, Ying Su, Hanumaiah Telikepalli, Ajia Town, Benjamin A. Turner, Lakshminarayana Vogeti, Subha Vogeti, Karen Yates, Filip Janku, Albiruni Ryan Abdul Razak, Oliver Rosen, Michael C. Heinrich, Daniel L. Flynn
Journal: Cancer Cell (2019)
Subclinical hypothyroidism: doctors shouldn’t routinely prescribe hormones
Authors: Elisabeth Mahase
Journal: BMJ (2019)

Thyroid hormones should not be routinely offered to adults with a mildly underactive thyroid gland, known as subclinical hypothyroidism, concludes a panel of international experts writing this week in The BMJ .1

Their advice is based on new evidence that found that treatment didn’t improve patients’ quality of life or symptoms, including low mood and fatigue.

Subclinical hypothyroidism affects up …
Everyone is affected, everyone a victim
Authors: Giuseppe Vetrugno, Fabio De-Giorgio, Federica Foti
Journal: BMJ (2019)

Clarkson and colleagues ask healthcare professionals to stop calling themselves “second victims” in cases of medical harm.1 What does the word “victim” mean? It comes from “victus,” a Latin term that means “defeated” or “beaten.”

When medical harm occurs, healthcare professionals have fought a battle and lost. Patients are victims, but they are …
Understanding the consequences of education inequality on cardiovascular disease: mendelian randomisation study
Authors: Alice R Carter, Dipender Gill, Neil M Davies, Amy E Taylor, Taavi Tillmann, Julien Vaucher, Robyn E Wootton, Marcus R Munafò, Gibran Hemani, Rainer Malik, Sudha Seshadri, Daniel Woo, Stephen Burgess, George Davey Smith, Michael V Holmes, Ioanna Tzoulaki, Laura D Howe, Abbas Dehghan
Journal: BMJ (2019)

Abstract Objectives To investigate the role of body mass index (BMI), systolic blood pressure, and smoking behaviour in explaining the effect of education on the risk of cardiovascular disease outcomes. Design Mendelian randomisation study. Setting UK Biobank and international genome-wide association study data. Participants Predominantly participants of European ancestry. Exposure Educational attainment, BMI, systolic blood pressure, and smoking behaviour in observational analysis, and randomly allocated genetic variants to instrument these traits in mendelian randomisation. Main outcomes measure The risk of coronary heart disease, stroke, myocardial infarction, and cardiovascular disease (all subtypes; all measured in odds ratio), and the degree to which this is mediated through BMI, systolic blood pressure, and smoking behaviour respectively. Results Each additional standard deviation of education (3.6 years) was associated with a 13% lower risk of coronary heart disease (odds ratio 0.86, 95% confidence interval 0.84 to 0.89) in observational analysis and a 37% lower risk (0.63, 0.60 to 0.67) in mendelian randomisation analysis. As a proportion of the total risk reduction, BMI was estimated to mediate 15% (95% confidence interval 13% to 17%) and 18% (14% to 23%) in the observational and mendelian randomisation estimates, respectively. Corresponding estimates were 11% (9% to 13%) and 21% (15% to 27%) for systolic blood pressure and 19% (15% to 22%) and 34% (17% to 50%) for smoking behaviour. All three risk factors combined were estimated to mediate 42% (36% to 48%) and 36% (5% to 68%) of the effect of education on coronary heart disease in observational and mendelian randomisation analyses, respectively. Similar results were obtained when investigating the risk of stroke, myocardial infarction, and cardiovascular disease. Conclusions BMI, systolic blood pressure, and smoking behaviour mediate a substantial proportion of the protective effect of education on the risk of cardiovascular outcomes and intervening on these would lead to reductions in cases of cardiovascular disease attributable to lower levels of education. However, more than half of the protective effect of education remains unexplained and requires further investigation.
Abstract 3481: Kisspeptin regulates the invasiveness of endometrial cancer cells through FAK/ Src signaling-dependent activation of matrix metalloproteinase (MMP)-2
Authors: Hsien-Ming Wu, Yung-Yu Liang, Wei-Jung Chiu, Hsin-Shih Wang, Hong-Yuan Huang, Chyong-Huey Lai, Yung-Kuei Soong
Journal: Cancer Research (2016)

Abstract Introduction: More than 25% of patients diagnosed with endometrial carcinoma have an invasive primary cancer accompanied by metastasis. The kisspeptin has an important role in reproduction. In mammals, kisspeptin may regulate tumor progression of endometrial cancer. FAK and Src signaling have been considered important components of tumor progression. MMPs are largely implicated in promoting angiogenesis and tumor metastasis. In the present study, we examined the action of kisspeptin-promoted motility of endometrial cancer cells and the mechanisms of the action in endometrial cancer. Materials and methods: Endometrial cancer cell line Ishikawa and ECC-1 were derived from an endometrial adenocarcinoma. Kisspeptin agonist and antagonist were synthetic peptides. Cell motility was estimated by invasion and migration assay. The activities of MMP-2 was assessed by gelatin zymography. Immunoblot analysis was done to study the expression of kisspeptin receptor and the effects of kisspeptin in the activation of FAK,Src and MMP-2. Human FAK siRNA and Src siRNA were used to knock down the expression of FAK and Src to evaluate the effects of FAK and Src. MMP-2 inhibitor (OA-Hy) was pretreated for 30 min to evaluate the effects of MMP-2 in cell motility. Results: The kisspeptin regulated cell motility in a dose-dependent manner. Kisspeptin activated the phosphorylation of FAK and Src signaling and the phosphorylation was abolished by FAK siRNA and Src siRNA. Kisspeptin-regulated cell motility was suppressed in cells pretreated with FAK siRNA and Src siRNA. Moreover, FAK siRNA and Src siRNA abolished kisspeptin-induced activation of MMP-2. Inhibition of MMP-2 with 10μM OA-Hy suppressed cell motility in response to kisspeptin. Conclusion: Our study shows that the kisspeptin regulated the cell motility of endometrial cancer cells through the kisspeptin receptor, and the phosphorylation of FAK and Src-dependent activation of MMP-2. Our findings represent a new concept regarding the mechanisms of kisspeptin-regulated cell motility in endometrial cancer cells, suggesting the possibility of kisspeptin analogues as a potential therapeutic intervention for the treatment of human endometrial cancer. Citation Format: Hsien-Ming Wu, Yung-Yu Liang, Wei-Jung Chiu, Hsin-Shih Wang, Hong-Yuan Huang, Chyong-Huey Lai, Yung-Kuei Soong. Kisspeptin regulates the invasiveness of endometrial cancer cells through FAK/ Src signaling-dependent activation of matrix metalloproteinase (MMP)-2. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 3481.
Есенціальні фосфоліпіди в терапії неалкогольної жирової хвороби печінки
Authors: Yu.М. Stepanov, Yu.A. Haidar, V.B. Yahmur, I.A. Klenina, D.V. Orlovskyi, I.S. Konenko, N.Yu. Oshmianska, L.O. Martynovа
Journal: GASTROENTEROLOGY (2020)

Неалкогольна жирова хвороба печінки (НЖХП) — метаболічно-індуковане захворювання, що виникає внаслідок інсулінорезистентності і характеризується жировою дистрофією печінки різного ступеня за відсутності інших чинників ураження печінки. Інсулінорезистентність призводить до посиленого ліполізу жирової тканини з надмірним вивільненням жирних кислот та накопиченням їх у печінці. Клінічне значення НЖХП полягає у можливості прогресування простого стеатозу до цирозу печінки. Проведено дослідження впливу лікувального комплексу, що включає препарат есенціальних фосфоліпідів енерлів, на показники цитолізу, спектр ліпідів крові та морфоструктурні зміни печінки у хворих на НЖХП. Обстеження пацієнтів після лікування виявило зниження активності трансаміназ, підвищення вмісту фракції фосфоліпідів крові та зниження коефіцієнта атерогенності. За даними контрольного сонографічного дослідження спостерігалось зменшення розмірів лівої частки печінки.
ANTIBIOTIC PROPHYLAXIS FOR EUS GUIDED FNA OF PANCREATIC CYSTIC LESIONS: A MULTICENTER, RANDOMIZED AND DOUBLE BLINDED CLINICAL TRIAL
Authors: J Colan Hernandez, O Sendino, C Loras, X Andujar, A Pardo, J Gornals, M Concepcion, C Sanchez Montes, M Murzi, G Fernandez Esparrach, A Gines, C Guarner Argente
Journal: Endoscopy (2019)

Routine antibiotic prophylaxis for EUS-FNA of pancreatic cysts is suggested in guidelines, but evidence is conflicting. The aim of the study was to investigate whether the procedure without antimicrobial prophylaxis does not increase the incidence of infection.
Increasing incidence of colorectal cancer in young adults in Europe over the last 25 years
Authors: Fanny ER Vuik, Stella AV Nieuwenburg, Marc Bardou, Iris Lansdorp-Vogelaar, Mário Dinis-Ribeiro, Maria J Bento, Vesna Zadnik, María Pellisé, Laura Esteban, Michal F Kaminski, Stepan Suchanek, Ondřej Ngo, Ondřej Májek, Marcis Leja, Ernst J Kuipers, Manon CW Spaander
Journal: Gut (2019)

Objective The incidence of colorectal cancer (CRC) declines among subjects aged 50 years and above. An opposite trend appears among younger adults. In Europe, data on CRC incidence among younger adults are lacking. We therefore aimed to analyse European trends in CRC incidence and mortality in subjects younger than 50 years. Design Data on age-related CRC incidence and mortality between 1990 and 2016 were retrieved from national and regional cancer registries. Trends were analysed by Joinpoint regression and expressed as annual percent change. Results We retrieved data on 143.7 million people aged 20–49 years from 20 European countries. Of them, 187 918 (0.13%) were diagnosed with CRC. On average, CRC incidence increased with 7.9% per year among subjects aged 20–29 years from 2004 to 2016. The increase in the age group of 30–39 years was 4.9% per year from 2005 to 2016, the increase in the age group of 40–49 years was 1.6% per year from 2004 to 2016. This increase started earliest in subjects aged 20–29 years, and 10–20 years later in those aged 30–39 and 40–49 years. This is consistent with an age-cohort phenomenon. Although in most European countries the CRC incidence had risen, some heterogeneity was found between countries. CRC mortality did not significantly change among the youngest adults, but decreased with 1.1%per year between 1990 and 2016 and 2.4% per year between 1990 and 2009 among those aged 30–39 years and 40–49 years, respectively. Conclusion CRC incidence rises among young adults in Europe. The cause for this trend needs to be elucidated. Clinicians should be aware of this trend. If the trend continues, screening guidelines may need to be reconsidered.
New Debates Surrounding the Histopathological Findings of Calciphylaxis—Do These Give Us New Insights Into Pathogenesis of the Disease?
Authors: Arturo R. Dominguez
Journal: JAMA Dermatology (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
ENDOSCOPIC LINE-ASSISTED COMPLETE CLOSURE OF LARGE COLONIC PERFORATION DURING ENDOSCOPIC SUBMUCOSAL DISSECTION
Authors: B Agudo, D De Frutos, J Santiago, I González, M González-Haba, A Garrido, P Matallanos, M Bote, E Blazquez, M Sol Delgado, A Herreros de Tejada
Journal: Endoscopy (2019)

Complete closure of extra-large mucosal defects after endoscopic submucosal dissection (ESD) of wide colorectal lesions is a challenging procedure due to limited width-opening of the regular through-the-scope clips (TTSC). We report a case of successful management of a large perforation using the line-assisted complete closure (LACC) technique.