tbuckley/cabot-search huggingface dataset:
Schedule-dependent anti-tumor effect of pemetrexed in combination with gemcitabine against malignant mesothelioma and lung cancer cell lines
Authors: Shinjiro Nagai, Shinya Itoh, Seiji Matsumoto, Makoto Sonobe, Masatsugu Nakagawa, Kazumasa Takenaka, Hiromichi Katakura, Masashi Adachi, Fumihiro Tanaka, Hiromi Wada
Journal: Cancer Research (2005)

5103  Backgrounds: Pemetrexed (MTA) is a novel multitargeted antifolate with a potent anti-tumor activity against a variety of malignant tumors including malignant pleural mesothelioma (MPM) and non-small cell lung cancer (NSCLC). Gemcitabine (GEM) also shows a certain anti-tumor activity against MPM and NSCLC, and is widely used in clinical practice. In the present study, we investigated in vitro combination effects of MTA and GEM against MPM and NSCLC cell lines in different schedules of drug administration. Materials and methods. A MPM cell line, 211H, and a NSCLC cell line, A549 were used, and MTA and GEM were administered on three different schedules as follows: (A) simultaneous exposure of MTA and GEM for 72 hours; (B) sequential exposure of GEM for 4 hours followed by MTA for 48 hours; (C) MTA for 24 hours followed by GEM for 4 hours. MTA and GEM were combined at a fixed concentration ratio according to the IC50 value of each drug. Cell viability was evaluated by WST-1 cell proliferation assay; combination effect was assessed by using the CalcuSyn software and represented as the combination index (Chou and Talalay). Results. IC50 values obtained in single-agent MTA treatment of 211H for 24, 48, and 72hrs were 7.06, 0.06, and 0.02μM, respectively. When MTA and GEM were administered according to the sequentiall combination schedule (C) (MTA followed by GEM), a synergistic effect was documented. IC50 values obtained in single-agent MTA treatment of A549 for 24, 48, and 72hrs were 7.39, 5.23, and 0.71μM, respectively. Combination treatment was antagonistic in any combination schedule in A549. Conclusions. Combined administration of MTA and GEM demonstrated a schedule-dependent effect on 211H, and a sequential administration (MTA followed by GEM) was the optimal combination schedule with a synergistic effect.
ACUTE PULMONAR EDEMA AND VENTRICULAR DYSFUNCTION DUE ADRENERGIC MYOCARDITIS ASSOCIATED TO PHEOCHROMOCYTOMA
Authors: Luiz Aparecido Bortolotto, Alexandre L. Bortolotto, Rafael Castro, Maria T.S. Sousa, Alexandre Soeiro, Adelaide Pereira
Journal: Journal of the American College of Cardiology (2019)
PREDICTION OF THE HEART RATE CORRECTED QT INTERVAL (QTC) FROM A NOVEL, MULTILEAD SMARTPHONE-ENABLED ECG USING A DEEP NEURAL NETWORK
Authors: Matthew Schram, Jacqueline Baras Shreibati, Martijn Bos, Conner Galloway, Alexander Valys, Frank Petterson, Vic Gundotra, Dave Albert, Zachi Itzhak Attia, Peter Noseworthy, Paul Friedman, Michael Ackerman
Journal: Journal of the American College of Cardiology (2019)
Histopathologic Acute Lung Injury after Allogeneic Hematopoietic Cell Transplantation: Clinical Findings, Radiologic Features, Treatments and Outcomes
Authors: Mehrdad Hefazi, Shahrukh K. Hashmi, Anja C. Roden, Mrinal M. Patnaik, Reona Sakemura, Nandita Khera, Vivek Roy, Cassie C. Kennedy, William J. Hogan, Mark R. Litzow, Hemang Yadav
Journal: Blood (2018)
Abstract 281: The Calcineurin/Rcan1 Axis Influences Mitochondrial Dynamics, Metabolism, and Biogenesis
Authors: Ngoc Uyen Nhi Nguyen, Francisco Altamirano, Valentina Parra, Beverly A Rothermel
Journal: Circulation Research (2018)

Rationale and Objective: The Regulator of Calcineurin 1 (RCAN1) inhibits calcineurin (CN), a Ca 2+ -activated protein phosphatase important in cardiac remodeling. The hearts and brains of Rcan1 KO mice are more susceptible to damage from ischemia/reperfusion (I/R). As mitochondria are known to be key mediators of I/R damage, the goal of our studies was to determine the impact of the CN/RCAN1 signaling axis on the mitochondrial network and function. Methods and Results: Using both neonatal and isolated adult cardiomyocytes, we found that, the mitochondrial network was more fragmented in the absence of RCAN1, due to increased CN-dependent activation of the fission protein DRP1. RCAN1-deficient cardiomyocytes had reduced mitochondrial membrane potential, consumed less O 2 , and generated lower levels of ROS. Importantly, they also displayed a reduced capacity for mitochondrial Ca 2+ uptake. RCAN1-depleted cardiomyocytes were more sensitive to I/R, however, pharmacological inhibition of CN, DRP1, or calpains (Ca 2+ -activated proteases) restored protection, suggesting that, in the absence of RCAN1, calpain-mediated damage following I/R is greater because of a decrease in the ability of mitochondria to buffer cytoplasmic Ca 2+ . Over-expression of RCAN1 was sufficient to enhance fusion. In addition to its impact on mitochondrial dynamics, CN activation also promoted mitochondrial biogenesis. We demonstrate that expression of the 1b isoform of PGC1α (a master regulator of mitochondrial biogenesis) is directly under CN control . In vivo, a cardiomyocyte-specific CN transgene caused a more rapid increase in: transcript levels for P gc 1α-1b and PolG (the mitochondrial DNA polymerase), mtDNA content, and the abundance of electron transport complex proteins. Despite the increase in mitochondrial content, changes in metabolic enzymes were consistent with a shift toward glycolysis rather than fatty acid oxidation. Conclusions: The CN/RCAN1 signaling axis helps determine both the number of mitochondria (DRP1-dependent fission) and the total mitochondrial mass ( Pgc1α -dependent biogenesis). Maintaining the proper level of these two processes is essential to cardiovascular health and metabolic flexibility.
CAN EFFICACY ECLIPSE SAFETY? THE ADDITIVE VALUE OF PACERS/ICDS IN THE CMR ENVIRONMENT
Authors: Robert W.W. Biederman, Loretta Gevenosky, Huma Samar, June Yamrozik, Ronald Williams, Richard Lombardi, Moneal Shah, Christopher Bonnet, Mark Doyle
Journal: Journal of the American College of Cardiology (2019)
EARLY PRESCRIPTION OF DIRECT ORAL ANTICOAGULANTS FOR ACUTE INTERMEDIATE-HIGH RISK PULMONARY EMBOLISM
Authors: Romain Chopard, Charly Eveno, Sebastien Humbert, Nicolas Falvo, Mathilde Morel, Benjamin Bonnet, Gabriel Napporn, Elsa Kalbacher, Laurent Obert, Bruno Degano, Gilles Capellier, Yves Cottin, Francois Schiele, Nicolas Meneveau
Journal: Journal of the American College of Cardiology (2019)
Publisher Correction: Microbial network disturbances in relapsing refractory Crohn’s disease
Authors: Bahtiyar Yilmaz, Pascal Juillerat, Ove Øyås, Charlotte Ramon, Francisco Damian Bravo, Yannick Franc, Nicolas Fournier, Pierre Michetti, Christoph Mueller, Markus Geuking, Valerie E. H. Pittet, Michel H. Maillard, Gerhard Rogler, Reiner Wiest, Jörg Stelling, Andrew J. Macpherson
Journal: Nature Medicine (2019)
Risk Factors for Pregnancy-Associated Venous Thromboembolism: The Role of Maternal Age, Obesity, Smoking and Other Modifiable Risk Factors
Authors: Rahil Kohli, Alison R. Moliterno, Michael B. Streiff, Michael R. DeBaun, Thomas S. Kickler, Karin Blakemore, Shruti Chaturvedi
Journal: Blood (2018)
REPRODUCIBILITY OF IN VIVO PULMONARY ARTERIAL REMODELING ASSESSMENT IN STABLE PULMONARY ARTERIAL HYPERTENSION
Authors: Enric Domingo, Alvaro Calabuig, Lopez-Messeguer Manuel, Santiago Perez-Hoyos, Carlos Bravo, Bernat Serra, Juan Grignola, Lindsay Kendall, Tony Cahn, Susan Fowles, Fred Wilson, Antonio Roman
Journal: Journal of the American College of Cardiology (2019)
EVOLUTION OF THE AMERICAN COLLEGE OF CARDIOLOGY AND THE AMERICAN HEART ASSOCIATION CARDIOLOGY CLINICAL PRACTICE GUIDELINES: A 10-YEAR ASSESSMENT
Authors: Victoria Dubose-Briski, Xiaoxi Yao, Shannon Dunlay, Sanket Dhruva, Joseph Ross, Nilay Shah, Peter Noseworthy
Journal: Journal of the American College of Cardiology (2019)
OUTCOMES ASSOCIATED WITH PERCUTANEOUS CORONARY INTERVENTION PRIOR TO TRANSCATHETER AORTIC VALVE IMPLANTATION
Authors: Manoj Thangam, Prashanth Thakker, Mustafa Husaini, John Posenau, Marc Sintek, Puja Kachroo, John Lasala, Spencer Melby, Nishath Quader, Hersh Maniar, Jasvindar Singh, Howard Kurz, Richard Bach, Amit Amin, Alan Zajarias
Journal: Journal of the American College of Cardiology (2019)
A Stromal Lysolipid–Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression
Authors: Francesca R. Auciello, Vinay Bulusu, Chet Oon, Jacqueline Tait-Mulder, Mark Berry, Sohinee Bhattacharyya, Sergey Tumanov, Brittany L. Allen-Petersen, Jason Link, Nicholas D. Kendsersky, Esmee Vringer, Michelle Schug, David Novo, Rosa F. Hwang, Ronald M. Evans, Colin Nixon, Craig Dorrell, Jennifer P. Morton, Jim C. Norman, Rosalie C. Sears, Jurre J. Kamphorst, Mara H. Sherman
Journal: Cancer Discovery (2019)

Abstract Pancreatic ductal adenocarcinoma (PDAC) develops a pronounced stromal response reflecting an aberrant wound-healing process. This stromal reaction features transdifferentiation of tissue-resident pancreatic stellate cells (PSC) into activated cancer-associated fibroblasts, a process induced by PDAC cells but of unclear significance for PDAC progression. Here, we show that PSCs undergo a dramatic lipid metabolic shift during differentiation in the context of pancreatic tumorigenesis, including remodeling of the intracellular lipidome and secretion of abundant lipids in the activated, fibroblastic state. Specifically, stroma-derived lysophosphatidylcholines support PDAC cell synthesis of phosphatidylcholines, key components of cell membranes, and also facilitate production of the potent wound-healing mediator lysophosphatidic acid (LPA) by the extracellular enzyme autotaxin, which is overexpressed in PDAC. The autotaxin–LPA axis promotes PDAC cell proliferation, migration, and AKT activation, and genetic or pharmacologic autotaxin inhibition suppresses PDAC growth in vivo. Our work demonstrates how PDAC cells exploit the local production of wound-healing mediators to stimulate their own growth and migration. Significance: Our work highlights an unanticipated role for PSCs in producing the oncogenic LPA signaling lipid and demonstrates how PDAC tumor cells co-opt the release of wound-healing mediators by neighboring PSCs to promote their own proliferation and migration. See related commentary by Biffi and Tuveson, p. 578. This article is highlighted in the In This Issue feature, p. 565
ASSOCIATION OF RISING VIOLENT CRIME WITH CARDIOVASCULAR OUTCOMES: LONGITUDINAL EVIDENCE FROM CHICAGO 2014-2016
Authors: Elizabeth L. Tung, Stephanie A. Besser, Rhys Chua, Marynia Kolak, Stacy T. Lindau, Emeka Anyanwu, James Liao, Corey Tabit
Journal: Journal of the American College of Cardiology (2019)
PREDICTORS AND CLINICAL OUTCOMES OF VASOPLEGIA IN PATIENTS BRIDGED TO HEART TRANSPLANTATION WITH CONTINUOUS FLOW LEFT VENTRICULAR ASSIST DEVICES
Authors: Rabea Asleh, Hilmi Alnsasra, Sarah D. Schettle, Riad Taher, Shannon Dunlay, John Stulak, Richard Daly, Atta Behfar, Naveen Pereira, Alfredo Clavell, Simon Maltais, Robert Frantz, Brooks Edwards, Sudhir Kushwaha
Journal: Journal of the American College of Cardiology (2019)
IMPLANTABLE CARDIOVERTER DEFIBRILLATOR IN PATIENTS WITH NON-ISCHEMIC CARDIOMYOPATHY IN THE UNITED STATES: INSIGHTS FROM THE NCDR ICD REGISTRY, AN NCDR® RESEARCH TO PRACTICE (R2P) PROJECT
Authors: Valentina Kutyifa, Haikun Bao, Yong-Mei Cha, Jonathan Hsu, Paul Varosy, Frederick Masoudi, Jeptha Curtis, Pamela Peterson
Journal: Journal of the American College of Cardiology (2019)
Infrared spectroscopy and onychomycosis
Authors: S. De Bruyne, R. Speeckaert, J. Boelens, M‐P. Hayette, M. Speeckaert, J. Delanghe
Journal: British Journal of Dermatology (2019)

Onychomycosis is a fungal infection of the nail. During recent decades, the rate of onychomycosis has been rising globally in relation to increases in important risk factors (e.g. diabetes mellitus) and lifestyle changes (e.g. occlusive footwear). Tests commonly used in the diagnosis of onychomycosis (such as potassium hydroxide preparation, histopathological examination with periodic acid‐Schiff stain and culture) are either time‐consuming or require specially trained personnel. Infrared spectroscopy allows doctors to look more closely at the skin than with the naked eye. Recently, the field of infrared spectroscopy has expanded into new and exciting uses due to significant improvements in the instruments used and the development of new techniques. The technique presents attractive features such as being fast, simple, non‐destructive and even portable. Furthermore, a minimum level of expertise is required with relatively low setup costs, i.e. one‐time fixed cost for the spectrometer. The aim of this study was to determine whether ‘Attenuated total reflectance Fourier transform infrared’ (ATR‐FTIR) spectroscopy can detect and differentiate causes of onychomycosis both in the lab and in patients. The study concluded that organisms that cause onychomycosis can be detected and differentiated in an easy and fast way by means of ATR‐FTIR spectroscopy. However, large‐scale investigations are necessary to determine its definite position compared to currently employed techniques.
PREDICTORS OF IN-HOSPITAL MORTALITY IN PATIENTS WITH ACUTE ST ELEVATION MYOCARDIAL INFARCTION AND CARDIOGENIC SHOCK REQUIRING PERCUTANEOUS LEFT VENTRICULAR ASSIST DEVICE PLACEMENT
Authors: James Kogut, Brent Dembo, Jovan Plamenac, Sumeet Lall, Ryan Wilson, Tariq Ali Ahmad, Chad Zack
Journal: Journal of the American College of Cardiology (2019)
TRANSLATION OF CLINICAL TRIAL TO REAL WORLD PRACTICE: CAN SACUBITRIL-VALSARTAN BE SAFELY TITRATED TO TARGET DOSE, 97/103MG BI-DAILY, IN CLINICAL PRACTICE AND WHAT BASELINE CHARACTERISTICS PREDICT SUCCESSFUL TITRATION?
Authors: Alexander Dashwood, Cassandra Vale, Shaaheen Laher, Haunnah Rheault, Scott Mckenzie, Yee Weng Wong
Journal: Journal of the American College of Cardiology (2019)
AN UNUSUAL CASE OF HYPERTROPHIC CARDIOMYOPATHY PHENOTYPE
Authors: Amina Adil, Renuka Jain, Rahul Sawlani, Patrycja Galazka, Adil Wani, Faraz Nasim Kazmi, Sameh A. Syed, A. Jamil Tajik
Journal: Journal of the American College of Cardiology (2019)
Relationship of Iron Deposition to Calcium Deposition in Human Aortic Valve Leaflets
Authors: Marion Morvan, Dimitri Arangalage, Grégory Franck, Fanny Perez, Léa Cattan-Levy, Isabelle Codogno, Marie-Paule Jacob-Lenet, Catherine Deschildre, Christine Choqueux, Guillaume Even, Jean-Baptiste Michel, Magnus Bäck, David Messika-Zeitoun, Antonino Nicoletti, Giuseppina Caligiuri, Jamila Laschet
Journal: Journal of the American College of Cardiology (2019)
18f-Fludeoxyglucose and 11c-Methionine PET/CT Scans in Patients with Multiple Myeloma Following Autologous Stem-Cell Transplantation (auto-HSCT)
Authors: Maxim V. Solovev, Larisa P. Mendeleeva, Maiia V. Firsova, Irakly P. Aslanidi, Olga V. Mukhortova, Valery G. Savchenko
Journal: Blood (2018)
LONG-TERM TICAGRELOR MONOTHERAPY IN ELDERLY PATIENTS UNDERGOING PCI IN THE GLOBAL LEADERS STUDY
Authors: Mariusz Tomaniak, Ply Chichareon, Rodrigo Modolo, Kuniaki Takahashi, Chun Chin Chang, Norihiro Kogame, Yuki Katagiri, Ernest Spitzer Cano, Pawel Buszman, Robert van Geuns, Veselin Valkov, Tobias Geisler, Janusz Prokopczuk, Christian Hamm, Philippe Steg, Manel Sabate, Krzysztof Zmudka, Peter Juni, Yoshinobu Onuma, Pascal Vranckx, Marco Valgimigli, Stephan Windecker, Patrick Serruys, Richard Anderson, Marcello Dominici
Journal: Journal of the American College of Cardiology (2019)
Abstract 296: Cd38 Deficiency Protects Heart From Lipid Overload-induced Oxidative Stress via Activating Sirt3/foxo3 Pathway
Authors: Ling Fang Wang, Cong Cong Huang, Yun Fei Xiao, Xiao Hui Guan, Xiao Nv Wang, Qing Cao, Yu Liu, Xuan Huang, Li Bin Deng, Ke Yu Deng, Hong Bo Xin
Journal: Circulation Research (2018)

Background/Aims: Our and other studies showed that CD38 deficiency protected heart from ischemia/reperfusion injury and high fat diet (HFD)-induced obesity in mice, respectively. However, the roles of CD38 in lipid overload-induced heart injury were not evaluated. In the present study, we investigated the preventive effects and mechanisms of CD38 deficiency on mouse heart injury induced by HFD. Methods: The discrepant metabolites in heart from wild type (WT) and CD38 knockout (CD38 -/- ) mice fed with HFD were examined using metabolomics analysis. The cell viability, the lactate hydrogenase (LDH) release, super oxide dismutase (SOD) activity, reactive oxygen species (ROS) production, triglyceride concentration and the expressions of various corresponding genes were examined for evaluating the effects of CD38 on oleic acid (OA)-induced cell injury using CD38 knockdown H9C2 stable cell line. Results: Our results revealed that CD38 deficiency significantly elevated the intracellular glutathione (GSH) concentration and GSH/GSSG ratio, decreased the contents of various free fatty acids and increased intracellular NAD + level in heart of CD38 -/- mice fed with HFD. Knockdown of CD38 significantly attenuated OA-induced cell injury, ROS production and lipid synthesis, seen as enhancing cell viability, reducing LDH release, elevating SOD activity, and decreasing triglyceride content and expressions of FASN in the CD38 knockdown H9C2 stable cell line. In addition, we also observed that the mitochondrial deacetylase Sirt3 and its target genes FOXO3 and SOD2 were upregulated in the stable cell lines after OA stimulation. Furthermore, the expressions of NOX2 and NOX4 were attenuated, accompanied by decreasing Bax expression and increasing Bcl-2 expression in the cells after OA stimulation. Conclusions: Our results demonstrated that CD38 deficiency protected heart from HFD-induced oxidative stress via activating Sirt3/FOXO3-mediated anti-oxidative stress pathway.
Abstract P4-03-05: Not presented
Authors: DM Carraro, EI Palmero, HC Galvao, CM Berra, RC Brianese, GT Torrezan, MN da Cruz Formiga, FT de Lima, GC Fernandes, AE de Paula, RD Michelli, AM Gutierrez Barrera, BK Arun
Journal: Cancer Research (2019)

Abstract This abstract was not presented at the conference. Citation Format: Carraro DM, Palmero EI, Galvao HC, Berra CM, Brianese RC, Torrezan GT, da Cruz Formiga MN, de Lima FT, Fernandes GC, de Paula AE, Michelli RD, Gutierrez Barrera AM, Arun BK. Not presented [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr P4-03-05.
TURN-DOWN FOR DONOR AGE AND SIZE HAS INCREASED FOR HEART TRANSPLANT CANDIDATES WITH MECHANICAL CIRCULATORY SUPPORT
Authors: Evan Kransdorf, Robert Cole, Jaime Moriguchi, Joshua Chung, Danny Ramzy, Jignesh Patel, Fardad Esmailian, Jon Kobashigawa
Journal: Journal of the American College of Cardiology (2019)
PREDICTORS OF WORSENING OR PERSISTENT TRICUSPID REGURGITATION AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Diane Tang, Mark Pianka, Andrea Lifrieri, Catherine Wang, Paul Armenta, Karina Guaman, Rawan Alhau, Anisha Vasireddi, Vratika Agarwal, Mariusz Wolbinski, Jonathan Rubin, Sahil Khera, Vivian Ng, Amisha Patel, Torsten Vahl, Omar Khalique, Vinayak Nilkanth Bapat, Martin Leon, Rebecca Hahn, Tamim Nazif, Susheel Kodali, Isaac George
Journal: Journal of the American College of Cardiology (2019)
REFRACTORY VERSUS RESISTANT HYPERTENSION: IS IT RELATED EXCESS SYMPATHETIC ACTIVITY?
Authors: Vinoda Sharma, Pankaj Gupta, Branislav Strauch, Samantha Wu, Mohamed Ali-Abdulnabi, Sowbaan Tarapuri, Jiri Widimsky, Prashanth Patel, Maciej Tomaszewski
Journal: Journal of the American College of Cardiology (2019)
TWELVE MONTH KINETICS OF CIRCULATING FIBROSIS-LINKED MICRORNAS (MIR-21, MIR-29, MIR-30, AND MIR-133A) AND THE RELATIONSHIP WITH EXTRACELLULAR MATRIX FIBROSIS IN DILATED CARDIOMYOPATHY
Authors: Pawel Rubis, Justyna Totoń-Żurańska, Maria Kołton-Wróż, Ewelina Pitera, Paweł Wołkow, Sylwia Wiśniowska-Śmiałek, Ewa Dziewięcka, Katarzyna Holcman, Ann Garlitski, Piotr Podolec
Journal: Journal of the American College of Cardiology (2019)
NATURAL O-GLYCANS ON ATRIAL NATRIURETIC PEPTIDE ATTENUATE THE ACUTE RENAL AND CARDIOVASCULAR ACTIONS IN VIVO
Authors: Lasse Hansen, Yang Chen, Dzhoyashvili Nina, Gerald Harders, Jeson Sangaralingham, Thomas Madsen, Henrik Clausen, Jens Rehfeld, Katrine Schjoldager, John Burnett, Jens Goetze
Journal: Journal of the American College of Cardiology (2019)
Abstract 20814: High Rate of Atrial Arrhythmias in Individuals With Truncating Titin Mutations Including the First Dilated Cardiomyopathy Related Titin Founder Mutation
Authors: Edgar T Hoorntje, Karin Y van Spaendonck-Zwarts, Wouter P te Rijdt, Ludolf Boven, Aryan Vink, Jasper J van der Smagt, Folkert W Asselbergs, Jan van Wijngaarden, Eric A Hennekam, Yigal Pinto, Ronald H Lekanne Deprez, Daniela Q Barge-Schaapveld, Marianne Bootsma, Jakub Regieli, Yvonne M Hoedemaekers, Jan D Jongbloed, Maarten P van den Berg, J. P van Tintelen
Journal: Circulation (2017)

Introduction: Truncating TTN variants (TTNtv) play an important role in the development of dilated cardiomyopathy (DCM). We collected evidence for the pathogenicity of TTN c.59926+1G>A, studied its founder effect and describe the associated phenotype including the presence of (paroxysmal) atrial fibrillation ((p)AF) and also evaluated this in carriers of other TTNtv. Methods: Clinical and genetic data from 11 probands and 19 family members with the TTN c.59926+1G>A variant were collected. We studied the founder effect by haplotype analysis and genealogy. We calculated the combined logarithm of the odds (LOD) score taking a penetrance of 80% into account. The presence of DCM and (p)AF) was further studied in 53 carriers of 16 other TTNtv. Results: TTN c.59926+1G>A: Haplotype analysis revealed a 4 Mb shared region, indicating a common ancestor. Genealogy going back five to nine generations revealed three pairs of common ancestors. Segregation analysis yielded a combined LOD score of 3.6. DCM was the predomi...
RADIAL VERSUS FEMORAL ACCESS FOR CHRONIC TOTAL OCCLUSION PERCUTANEOUS INTERVENTION: SYSTEMATIC REVIEW AND META-ANALYSIS OF IN-HOSPITAL OUTCOMES
Authors: Aris Karatasakis, Barbara Danek, Khaldoon Alaswad, Stéphane Rinfret, Dimitrios Karmpaliotis, Yader Sandoval, Ahmad Alkhalil, Anthony Lucev, Subhash Banerjee, Emmanouil Brilakis
Journal: Journal of the American College of Cardiology (2019)