tbuckley/cabot-search huggingface dataset:
Abstract 12087: Prevalence and Prognostic Implications of CMR Detected Myocardial Fibrosis in Patients With Mitral Valve Prolapse
Authors: Danai Kitkungvan, Faisal Nabi, Raymond J Kim, Robert Bonow, Jiaqiong Xu, Stephen H Little, Miguel Quinones, Gerald Lawrie, William A Zoghbi, Dipan J Shah
Journal: Circulation (2016)

Background: Mitral valve prolapse (MVP) is the most common cause of primary mitral regurgitation (MR). Arrhythmia and sudden cardiac death (SCD) have been associated with MVP; however, the mechanism is unclear. Prior studies suggested left ventricular (LV) fibrosis as an arrhythmic substrate. Hypothesis: MVP patients have an increased prevalence of LV fibrosis which associated with adverse outcome. Methods: Patients referred for CMR to assess mitral valve disease were enrolled. Confounding causes of LV fibrosis (CAD, LVEF &lt; 50% etc.) and secondary MR were excluded. Primary MR patients were classified into MVP (&gt;2 mm leaflet displacement) and a non-MVP group. Cine, phase contrast CMR were performed to assess cardiac morphology/function and MR severity. Late gadolinium enhancement (LGE) CMR was performed to identify LV fibrosis. Patients were followed for 1) arrhythmic events comprised of SCD/aborted SCD, or sustained/inducible ventricular arrhythmia requiring ICD and 2) composite outcome that included arrhythmic events or cardiovascular death. Results: 356 primary MR patients (177 MVP, and 179 non-MVP) were enrolled. Baseline characteristics were relatively similar except MVP patients had more severe MR (MR fraction 42.1±14.3% vs. 32.8±12.2%, p&lt;0.03). LGE representing LV fibrosis was more prevalent in MVP group (36.7% vs. 6.7%, p&lt;0.001) and for each MR severity (figure 1A). On multivariate analysis, although lower LVEF, and increasing MR severity were associated with increased LV fibrosis, presence of MVP had the strongest association (OR 6.82, p &lt; 0.001). During the follow up period (median 673 days), MVP patients with LV fibrosis had the highest annualized event rate for arrhythmic events and composite outcome (figure1B). Conclusion: LV fibrosis is more prevalent in MVP than non-MVP patients with primary MR suggesting a unique pathophysiology in MVP. Presence of LV fibrosis in MVP may represent a risk marker of arrhythmic events and adverse clinical outcome.
Implementation of a team training program in the treatment of breast cancer patients.
Authors: Craig A. Bunnell, Anne Gross, Michael Kalfin, Ann H. Partridge, Sharon Lane, Harold J. Burstein, Barbara Fine, Nancy Hilton, Clare Sullivan, Lynn Colicchio, Erin Hagemeister, Anne Kelly, Audrea Szabatura, Eric Winer, Susan Mann, Saul Weingart
Journal: Journal of Clinical Oncology (2012)

e16515 Background: Team Training (TT) principles, used in high-risk industries to reduce errors and improve communication and task coordination, have been applied in other areas of medicine, but never in an outpatient subspecialty setting. We piloted a TT program in a large, academic breast cancer program. Methods: Observations, interviews and anonymous adverse event reporting systems were used to identify areas of vulnerability warranting intervention: 1) communication of changes in chemotherapy orders on the day of treatment ("change orders") 2) missing orders on treatment days that patients were not also scheduled to see their physician (“unlinked” visits) 3) follow-up and communication to other team members on important patient issues (e.g. pending test results or changes in patient status) 4) conflict resolution between providers and staff. For each area, agreements about roles, responsibilities and behaviors were made. Using a train-the-trainer model, clinical leaders trained all providers and staff in TT principles, the agreements, and the tools to support them. Results: The program was evaluated six months after implementation. There was insufficient power to detect a significant difference in communication of change orders because of the infrequency of events (&lt; 2% pre and post-training). However, 100% of providers reported it was easier to communicate change orders and 87% of infusion nurses reported a decrease in non-communicated changes. The incidence of missing orders for unlinked visits decreased from 30% to 2%. Press-Ganey patient satisfaction scores suggested improvement in patient perception of care coordination. Providers, infusion nurses and support staff reported strongly positive perceptions of improvement in efficiency (75%, 86%, 90%), quality (82%, 93%, 93%) and safety (92%, 92%, 90%) of patient care. Similarly, all groups reported improved relationships and more respectful behavior among team members (91%, 85%, 93%). Conclusions: Team Training improved communication, task coordination and perceptions of efficiency, quality, safety and interactions among team members as well as patient perception of care coordination. Widespread implementation of this strategy is ongoing at our institution.
Extravesicular Mir-7977 Released from Leukemic Cells Inhibites the PCBP1-Mediated mRNA Stabilization and Hippo-YAP Signaling Pathway in Bone Marrow Mesenchymal Stromal Cells
Authors: Masahiro Yoshida, Satoshi Iyama, Hiroto Horiguchi, Akari Goto, Shohei Kikuchi, Kazuyuki Murase, Kohichi Takada, Koji Miyanishi, Hiroshi Ikeda, Masahiro Maeda, Junji Kato, Masayoshi Kobune
Journal: Blood (2018)
Extremely Preterm Birth Outcomes in Sweden
Authors: Matthew A. Rysavy, Danielle E. Y. Ehret
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comment on Cheng et al. Trends and Disparities in Cardiovascular Mortality Among U.S. Adults With and Without Self-Reported Diabetes, 1988–2015. Diabetes Care 2018;41:2306–2315
Authors: Valeria Manicardi, Massimo Vicentini, Paola Ballotari, Francesco Venturelli, Paolo Giorgi Rossi
Journal: Diabetes Care (2019)

We read with great interest the recently published article by Cheng et al. (1). The authors note that there was a dramatic increase in prevalence (age-standardized) between the 1980s and 2010 (3% and 9%, respectively) in the population with diabetes compared with the population without, along with a decrease in the excess risk of cardiovascular disease (CVD). The authors attribute this excess risk reduction to an improvement in primary and secondary diabetes care.

However, it must be remembered that the diabetes diagnostic criteria have changed over the years. In 1997, the fasting blood glucose threshold …
QIM19-144: Health-Related Quality of Life and Stress Level in Patients After Thyroid Resection Due to Cancer Depends on Patients’ Knowledge About Their Disease and Treatment Plan: Preliminary Results
Authors: Arkadiusz Spychala, Michal Oko, Olga Zając-Spychala, Witold Kycler
Journal: Journal of the National Comprehensive Cancer Network (2019)

Background: Relevant information is a prerequisite for patients to acquire enough knowledge to enable them to be actively involved in shared decision making, to comply with the treatment plan, and to understand what are potential benefits and side-effects of proposed therapy. Aim: The aim of this prospective, longitudinal study was to investigate whether cancer patients’ level of knowledge about their disease and treatment was associated with their health-related quality of life (HRQOL), particularly stress level. Patients and Methods: From October 2017 till September 2018, 41 patients aged 26–69 (median, 42) years referred for curative thyroidectomy were included into the study. EORTC QLQ-INFO25 questionnaire was used to measure level of patients’ knowledge about their disease and treatment, while thyroid-specific HRQOL was measured using Polish version of ThyPRO questionnaire and stress level by COPE Inventory. Assessments were done directly before the surgery (T1), 3 months after (T2), and 6 months after the treatment (T3). Results: The information about the disease (T1: 39.2, T2: 47.6, T3: 52.8; P =.024), information about treatment (T1: 27.2, T2: 42.6, T3: 60.8; P &lt;.001), information about what patients can do to help themselves (T1: 22.6, T2: 39.4, T3: 52.2; P =.037), and satisfaction with the received information (T1: 32.6, T2: 41.0, T3: 49.7; P =.049) increased significantly during the study period. Moreover, the proportion of patients who wished they had received more information decreased from 59.4% at T1 to 22.8% at T3 ( P &lt;.001). Almost all of HRQOL domain scores were increasing in the consecutive time points with respect to role-physical (T1: 72.7, T2: 79.2, T3: 80.7; P =.003), role-emotional (T1: 77.6, T2: 82.8, T3: 88.9; P =.001), general health (T1: 52.7, T2: 60.2, T3: 63.4; P &lt;.001), physical functioning (T1: 69.7, T2: 77.8, T3: 79.4; P =.011), social functioning (T1: 82.7, T2: 88.9, T3: 89.4; P =.047), and vitality (T1: 69.3, T2: 72.8, T3: 79.9; P &lt;.001). Based on COPE Inventory, from the relative scores on various coping strategies in each time point, the 5 most common coping strategies adopted were active coping, planning, suppression of competing activities, focus on emotions, and positive reinterpretation and growth. There was significant correlation between EORTC QLQ-INFO25, ThyPRO, and COPE Inventory, in particular study time point ( P &lt;.001). Conclusions: Patients’ knowledge increased significantly during the study period, and they reported that they felt better informed and were more satisfied with the information. This significantly influenced improvement of HRQOL and stress reduction. Psychological outcome must be considered as important measurement assessing treatment effect.
Data sharing practices of medicines related apps and the mobile ecosystem: traffic, content, and network analysis
Authors: Quinn Grundy, Kellia Chiu, Fabian Held, Andrea Continella, Lisa Bero, Ralph Holz
Journal: BMJ (2019)

Abstract Objectives To investigate whether and how user data are shared by top rated medicines related mobile applications (apps) and to characterise privacy risks to app users, both clinicians and consumers. Design Traffic, content, and network analysis. Setting Top rated medicines related apps for the Android mobile platform available in the Medical store category of Google Play in the United Kingdom, United States, Canada, and Australia. Participants 24 of 821 apps identified by an app store crawling program. Included apps pertained to medicines information, dispensing, administration, prescribing, or use, and were interactive. Interventions Laboratory based traffic analysis of each app downloaded onto a smartphone, simulating real world use with four dummy scripts. The app’s baseline traffic related to 28 different types of user data was observed. To identify privacy leaks, one source of user data was modified and deviations in the resulting traffic observed. Main outcome measures Identities and characterisation of entities directly receiving user data from sampled apps. Secondary content analysis of company websites and privacy policies identified data recipients’ main activities; network analysis characterised their data sharing relations. Results 19/24 (79%) of sampled apps shared user data. 55 unique entities, owned by 46 parent companies, received or processed app user data, including developers and parent companies (first parties) and service providers (third parties). 18 (33%) provided infrastructure related services such as cloud services. 37 (67%) provided services related to the collection and analysis of user data, including analytics or advertising, suggesting heightened privacy risks. Network analysis revealed that first and third parties received a median of 3 (interquartile range 1-6, range 1-24) unique transmissions of user data. Third parties advertised the ability to share user data with 216 “fourth parties”; within this network (n=237), entities had access to a median of 3 (interquartile range 1-11, range 1-140) unique transmissions of user data. Several companies occupied central positions within the network with the ability to aggregate and re-identify user data. Conclusions Sharing of user data is routine, yet far from transparent. Clinicians should be conscious of privacy risks in their own use of apps and, when recommending apps, explain the potential for loss of privacy as part of informed consent. Privacy regulation should emphasise the accountabilities of those who control and process user data. Developers should disclose all data sharing practices and allow users to choose precisely what data are shared and with whom.
Psoralen Plus UV-A Therapy in the 21st Century
Authors: Joan Guitart
Journal: JAMA Dermatology (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Role of nitric oxide in the anti-tumoral effect of retinoic acid and 1,25-dihydroxyvitamin D3 on human promonocytic leukemic cells
Authors: N Dugas, MD Mossalayi, A Calenda, A Leotard, P Becherel, F Mentz, F Ouaaz, M Arock, P Debre, J Dornand, B Dugas
Journal: Blood (1996)
Interpretation of Studies on the Occurrence of Atrial Fibrillation in Elite Athletes
Authors: Maarten J. G. Leening, M. Arfan Ikram
Journal: JAMA Cardiology (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Poetry and Medicine
Authors: Robert S. McKelvey
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sex and Repression in Savage Society.
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CLO19-025: Treatment Discontinuation Due to Adverse Events and the Risk of Gastrointestinal Toxicities in Patients With Hematologic Malignancies Treated With Ibrutinib
Authors: Meily Arevalo, Myo H. Zaw, Anita Sultan, Sriman Swarup, Nay N. Yee, Wai L. Thein, Myet M. Zin, Nusrat Jahan, Kyaw Z. Thein
Journal: Journal of the National Comprehensive Cancer Network (2019)

Background: Ibrutinib targets Bruton’s tyrosine kinase, a kinase involved in signaling of B-cell and chemokine receptors, which are implicated in the pathogenesis of hematologic malignancies. Ibrutinib has been shown to improve survival in hematologic malignancies, and yet the tolerability has not been elucidated. We undertook systematic review and pooled analysis of randomized controlled trials (RTCs) to determine the risk of gastrointestinal toxicities and the rate of treatment discontinuation due to adverse events. Methods: We performed a comprehensive literature search using MEDLINE, EMBASE databases and meeting abstracts through September 2018. Phase 3 RCTs that mention gastrointestinal toxicities and the rate of treatment discontinuation due to adverse events were incorporated in the analysis. Mantel-Haenszel method was used to calculate the estimated pooled risk ratio with 95% CI. Random effects model was applied. Results: 6 phase III RCTs with a total of 1,811 patients with chronic lymphocytic leukemia/small lymphocytic lymphoma, mantle cell lymphoma, and Waldenstrom’s macroglobulinemia were included. Studies comparing ibrutinib vs ofatumumab, ibrutinib vs chlorambucil, ibrutinib + bendamustine + rituximab vs placebo + bendamustine + rituximab, ibrutinib vs temsirolimus, and ibrutinib vs rituximab were included in the analysis. The incidence of treatment discontinuation due to adverse events was 9.30% in the ibrutinib group vs 13.13% in the control arm. The relative risk (RR) for treatment discontinuation was 0.740 (95% CI: 0.385–1.423; P =.367). The pooled RR of all-grade side effects were as follows: diarrhea, 1.955 (95% CI: 1.304–2.933; P =.001); nausea, 1.038 (95% CI: 0.702–1.534; P =.852); vomiting, 1.048 (95% CI: 0.547–2.007; P =.888); and stomatitis, 1.262 (95% CI: 0.112–14.173; P =.850). The RR of high-grade adverse effects were as follows: diarrhea, 1.749 (95% CI: 0.866–3.530; P =.119); nausea, 2.237 (95% CI: 0.478–10.471; P =.306); vomiting, 0.429 (95% CI: 0.111–1.659; P =.220); and stomatitis, 0.309 (95% CI: 0.028–3.440; P =.340). Conclusion: Our study demonstrated that patients on ibrutinib arm noted increased risk of all-grade diarrhea. Nevertheless, other GI toxicities as well as treatment discontinuation due to adverse events were not statistically significant in the ibrutinib group compared with the control arm.
Ентеропанкреатичний синдром і його вплив на трофологічні порушення при хронічному панкреатиті
Authors: L.S. Babinets, Yu.Ya. Kotsaba, O.V. Denefil
Journal: GASTROENTEROLOGY (2013)

При дослідженні мікрофлори товстого кишечника у хворих на хронічний панкреатит у 72 % випадків був знайдений дисбіоз різного ступеня вираженості. Було виявлено, що дисбіотичні зміни спричинюють збільшення загального рівня білка крові, м’язової маси плечей та індексу маси тіла. Вони також призведуть до формування й збільшення вторинної імунної недостатності внаслідок підвищення кількості Т- і В-лімфоцитів. Був виявлений вірогідний прогностичний вплив мікрофлори товстого кишечника у хворих із хронічним панкреатитом на формування й прогресування анемії на підставі вірогідної кореляції між рівнями гемоглобіну й еритроцитів крові та кількістю лакто- і біфідобактерій (R у межах 0,3–0,6), а також умовно-патогенних організмів і загальної кількості E.coli (R у межах (–0,3) — (–0,6)).