Katayama Syndrome Without <i>Schistosoma mansoni</i> Eggs
Authors: Marijke C.C. Langenberg, Marie-Astrid Hoogerwerf, Jacqueline J. Janse, Lisette van Lieshout, Paul L.A.M. Corstjens, Meta Roestenberg
Journal: Annals of Internal Medicine (2019)

Letters21 May 2019Katayama Syndrome Without Schistosoma mansoni EggsMarijke C.C. Langenberg, MD, Marie-Astrid Hoogerwerf, MD, Jacqueline J. Janse, MSc, Lisette van Lieshout, PhD, Paul L.A.M. Corstjens, PhD, and Meta Roestenberg, MD, PhD, on behalf of the CoHSI clinical trial team*Marijke C.C. Langenberg, MDLeiden University Medical Center, Leiden, the Netherlands (M.C.L., M.H., J.J.J., L.V., P.L.C., M.R.), Marie-Astrid Hoogerwerf, MDLeiden University Medical Center, Leiden, the Netherlands (M.C.L., M.H., J.J.J., L.V., P.L.C., M.R.), Jacqueline J. Janse, MScLeiden University Medical Center, Leiden, the Netherlands (M.C.L., M.H., J.J.J., L.V., P.L.C., M.R.), Lisette van Lieshout, PhDLeiden University Medical Center, Leiden, the Netherlands (M.C.L., M.H., J.J.J., L.V., P.L.C., M.R.), Paul L.A.M. Corstjens, PhDLeiden University Medical Center, Leiden, the Netherlands (M.C.L., M.H., J.J.J., L.V., P.L.C., M.R.), and Meta Roestenberg, MD, PhDLeiden University Medical Center, Leiden, the Netherlands (M.C.L., M.H., J.J.J., L.V., P.L.C., M.R.), on behalf of the CoHSI clinical trial team*Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L18-0438 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Katayama syndrome is a self-limited illness that occurs several weeks after infection with schistosome larvae (cercariae). Its symptoms are typical of an acute inflammatory response.Objective: To provide insight into the cause of Katayama syndrome.Case Report: We exposed 2 human participants to male cercariae of Schistosoma mansoni in an experimental infection that met all applicable laws and regulations, was approved by the Ethical Research Committee of Leiden University Medical Center (study P16.111), and was registered at ClinicalTrials.gov (NCT02755324).The first patient was a healthy 24-year-old medical student with a history of hay fever and mild atopic dermatitis. We ...References1. Ross AG, Vickers D, Olds GR, Shah SM, McManus DP. Katayama syndrome. Lancet Infect Dis. 2007;7:218-24. [PMID: 17317603] CrossrefMedlineGoogle Scholar2. Corstjens PL, Nyakundi RK, de Dood CJ, Kariuki TM, Ochola EA, Karanja DM, et al. Improved sensitivity of the urine CAA lateral-flow assay for diagnosing active Schistosoma infections by using larger sample volumes. Parasit Vectors. 2015;8:241. [PMID: 25896512] doi:10.1186/s13071-015-0857-7 CrossrefMedlineGoogle Scholar3. Utzinger J, Becker SL, van Lieshout L, van Dam GJ, Knopp S. New diagnostic tools in schistosomiasis. Clin Microbiol Infect. 2015;21:529-42. [PMID: 25843503] doi:10.1016/j.cmi.2015.03.014 CrossrefMedlineGoogle Scholar4. Janse JJ, Langenberg MCC, Kos-Van Oosterhoud J, Ozir-Fazalalikhan A, Brienen EAT, Winkel BMF, et al. Establishing the production of male Schistosoma mansoni cercariae for a controlled human infection model. J Infect Dis. 2018;218:1142-6. [PMID: 29905805] doi:10.1093/infdis/jiy275 CrossrefMedlineGoogle Scholar5. Rocha MO, Greco DB, Pedroso ER, Lambertucci JR, Rocha RL, Rezende DF, et al. Secondary cutaneous manifestations of acute schistosomiasis mansoni. Ann Trop Med Parasitol. 1995;89:425-30. [PMID: 7487229] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Leiden University Medical Center, Leiden, the Netherlands (M.C.L., M.H., J.J.J., L.V., P.L.C., M.R.)Financial Support: Dr. Roestenberg was supported by a Veni grant from The Netherlands Organization for Health Research and Development (ZonMW) and a Gisela Thier Fellowship from Leiden University Medical Center. Drs. Langenberg and Hoogerwerf were supported by a grant from Dioraphte Foundation. The funding sources had no role in collecting, analyzing, interpreting, or reporting the data.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L18-0438.This article was published at Annals.org on 8 January 2019.*Members of the CoHSI clinical trial team who contributed to this work but did not author it are G.J. van Dam, A. van Diepen, C.J. de Dood, C. Feijt, M.S. Ganesh, H. Gerritsma, G. Hardeman, C.H. Hokke, J.P.R. Koopman, J. Kos-van Oosterhoud, Y.C.M. Kruize, P. Meij, A. Ozir-Fazalalikhan, R. van Schuijlenburg, H.H. Smits, P.H. Verbeek-Menken, L.G. Visser, J.J.C. de Vries, B.M.F. Winkel, and M. Yazdanbakhsh. 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