tbuckley/cabot-search huggingface dataset:
Minimally Invasive Surgery
Authors: K. H. Fuchs
Journal: Endoscopy (2002)

During the last 10 years, minimally invasive surgery has influenced the techniques used in every specialty of surgical medicine. This development has not only led to the replacement of conventional procedures with minimally invasive ones, but has also stimulated surgeons to reevaluate conventional approaches with regard to perioperative parameters such as pain medication. However, two major drawbacks have emerged with the introduction of this new technique: firstly, the prolonged learning curve for most surgeons, in comparison with the learning process in open surgery; and secondly, increased costs due to investment in the equipment required and the use of disposable instruments, as well as longer operating times. In the various health-care systems around the world, these increased costs are not always compensated for by shorter hospital stays. This review focuses on major areas of indication for minimally invasive surgery in the gastrointestinal tract. These include functional disorders of the upper and lower gastrointestinal tract, obesity surgery, minimally invasive techniques in gastric and hepatobiliary surgery and in other solid organs, and laparoscopic colorectal surgery. The shortening of the hospitalization period has led to increasing use of outpatient laparoscopic surgery, and many centers specializing in day-care surgery are using these techniques. The frontiers are being pushed even further, as the size of the instruments is reduced to achieve better cosmetic results. Clinical research has also focused on the topic of expanding the indications for minimally invasive approaches in the elderly and in high-risk patients, to take advantage of the shorter hospital stays and reduced surgical trauma that are possible. A considerable amount of basic research has been carried out on the stress response during and after minimally invasive procedures, and an improved immune response with the minimally invasive approach has been observed, leading to better results after extensive oncological procedures. Robotic surgery and telesurgery involve new computer-aided methods that allow greater precision in surgical technique, as well as offering an opportunity to supply surgical skill and expertise remotely, over long distances. Minimally invasive surgical techniques are thus now fully established in routine use, and the indications are continuing to expand.
NON-STEROIDAL ANTI-INFLAMMATORY DRUG-INDUCED ENTEROPATHY AS A MAJOR RISK FACTOR FOR SMALL BOWEL BLEEDING
Authors: SW Jung, SB Lee, JH Park, KW Jung, JH Kim, W Moon, SJ Park
Journal: Endoscopy (2020)

Aims Small bowel (SB) bleeding has been known to account for 5% of all gastrointestinal (GI) bleeding cases and 80% of obscure GI bleeding cases. Although angioectasia is the common etiology of SB bleeding, non-steroidal anti-inflammatory drug (NSAID)-induced SB lesion is also reported as a major cause in previous studies from the Eastern countries. Herein, we assessed the frequency of NSAID-induced SB lesion in Korean patients with obscure GI bleeding.
Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer (vol 41, pg 991, 2009)
Authors: X Wu, Y Ye, L A Kiemeney, P Sulem, T Rafnar, G Matullo, D Seminara, T Yoshida, N Saeki, A S Andrew, C P Dinney, B Czerniak, Zhang Z-F., A E Kiltie, D T Bishop, P Vineis, S Porru, F Buntinx, E Kellen, M P Zeegers, R Kumar, P Rudnai, E Gurzau, K Koppova, J I Mayordomo, M Sanchez, B Saez, A Lindblom, P de Verdier, G Steineck, G B Mills, A Schned, Chang S-C., J Lin, D W Chang, K S Hale, T Majewski, H B Grossman, S Thorlacius, U Thorsteinsdottir, Aben Kkh., J A Witjes, K Stefansson, C I Amos, M R Karagas, J Gu, S Guarrera, S Polidoro
Journal: Nature Genetics (2009)
Reduction in Obesity and Related Comorbid Conditions after Diet-Induced Weight Loss or Exercise-Induced Weight Loss in Men
Authors: Robert Ross, Damon Dagnone, Peter J.H. Jones, Heidi Smith, Anne Paddags, Robert Hudson, Ian Janssen
Journal: Annals of Internal Medicine (2000)

Weight loss induced by increased daily physical activity without caloric restriction substantially reduced obesity (particularly abdominal obesity) and insulin resistance in men. Exercise without w...
Phase II study of peginterferon alpha-2b for patients with unresectable or recurrent craniopharyngiomas: a Pediatric Brain Tumor Consortium report
Authors: Stewart Goldman, Ian F Pollack, Regina I Jakacki, Catherine A Billups, Tina Y Poussaint, Adekunle M Adesina, Ashok Panigrahy, Donald W Parsons, Alberto Broniscer, Giles W Robinson, Nathan J Robison, Sonia Partap, Lindsay B Kilburn, Arzu Onar-Thomas, Ira J Dunkel, Maryam Fouladi
Journal: Neuro-Oncology (2020)

Craniopharyngiomas account for approximately 1.2-4% of all CNS tumors. They are typically treated with a combination of surgical resection and focal radiotherapy. Unfortunately, treatment can lead to permanent deleterious effects on behavior, learning, and endocrine function.The Pediatric Brain Tumor Consortium performed a multicenter phase 2 study in children and young adults with unresectable or recurrent craniopharyngioma (PBTC-039). Between December 2013 and November 2017, nineteen patients (median age at enrollment, 13.1 y; range, 2-25 y) were enrolled in one of 2 strata: patients previously treated with surgery alone (stratum 1) or who received radiation (stratum 2).Eighteen eligible patients (8 male, 10 female) were treated with weekly subcutaneous pegylated interferon alpha-2b for up to 18 courses (108 wk). Therapy was well tolerated with no grade 4 or 5 toxicities. 2 of the 7 eligible patients (28.6%) in stratum 1 had a partial response, but only one response was sustained for more than 3 months. None of the 11 stratum 2 patients had an objective radiographic response, although median progression-free survival was 19.5 months.Pegylated interferon alpha-2b treatment, in lieu of or following radiotherapy, was well tolerated in children and young adults with recurrent craniopharyngiomas. Although objective responses were limited, progression-free survival results are encouraging, warranting further studies.
Barrett’s Epithelial Thickness, Assessed by Volumetric Laser Endomicroscopy, Is Associated With Response to Radiofrequency Ablation
Authors: Iris J.M. Levink, Guillermo J. Tearney, Nicole S. Erler, Herbert C. Wolfsen, Peter D. Siersema, Michael B. Wallace
Journal: Clinical Gastroenterology and Hepatology (2020)
MANAGEMENT OF ESOPHAGEAL AND PYLORIC COMPLEX CAUSTIC INJURY: A MULTIMODALITY APPROACH
Authors: C Robles-Medranda, M Khashab, R Oleas, J Alcivar-Vasquez
Journal: Endoscopy (2020)

Caustic-induced gastric outlet obstruction impacts patients’ quality of life. Repetitive session of endoscopic balloon dilation has a limited efficacy in caustic induced injury and carries the risk of perforation and recurrence. Surgical gastrojejunostomy has a high complication rate for the management of both benign and malignant gastric outlet obstruction. The multimodality approach using the placement of fully covered self-expandable metal stents, biodegradable stents and EUS-guided gastroenterostomy could be an effective alternative in the management of complex mixed caustic-induced injuries. The multimodality approach produces long-term symptoms relief, weight regain, resuming the oral intake, improving the nutritional status and quality of life.
ESD INSIDE A COLON DIVERTICULUM OF THE CECUM, USING THE CLIP AND BAND TECHNIQUE, THE SALINE IMMERSION TECHNIQUE AND THE POCKET CREATION METHOD
Authors: G Mavrogenis, I Tsevgas, D Zachariadis
Journal: Endoscopy (2020)

Aims Presentation of a case of endoscopic submucosal dissection (ESD) of a polyp at the cecum located inside a diverticulum.
RISK FACTORS OF FAILURE AND COMPLICATIONS FOR ENDOSCOPIC COLORECTAL STENTING
Authors: A Vodoleev, D Kriazhev, V Duvanskiy, S Pirogov, I Perfil’ev, E Karpova, D Sukhin, V Veselov, T Belyaeva
Journal: Endoscopy (2020)

Aims Stenting is an effective method of decompression for patients with malignant colorectal obstruction. Widespread adoption is resticted due to relatively high rate of failure and complications. Аccording to publications, we have very limited and unsystematic data about risk factor. The aim of our study was to analyze the factors influencing the occurrence of failure and complications after colorectal stenting.
COMBINED ULTRASOUND- AND FLUOROSCOPY-GUIDED TRANSHEPATIC BILIARY DRAINAGE IS SUPERIOR TO CONVENTIONAL RADIOGRAPHY-GUIDED TECHNIQUE
Authors: M Hollenbach, T Schaumburg, J Feisthammel, P Michl, J Rosendahl, A Hoffmeister
Journal: Endoscopy (2020)

Aims Difficult biliary cannulation (DBC) is a common condition in endoscopy and often remains challenging. DBC is related to benign, malignant or iatrogenic diseases. In case of unsuccessful ERCP, bile duct access can be achieved alternately by EUS-guided or percutaneous transhepatic biliary drainage (PTBD). PTBD is often performed by combined fluoroscopy and ultrasound-guided puncture (US-PTBD) but also conducted without sonography (F-PTBD). However, there is very little data evaluating US-PTBD or showing any superiority for the use of US-PTBD in technical access or complications. Therefore, we performed a retrospective, two-center study comparing US-PTBD and F-PTBD.
COMBINED THERAPY IN THE MANAGEMENT OF COMPLEX BENIGN ESOPHAGEAL STRICTURES: FULLY COVERED SELF-EXPANDABLE METALLIC STENTS AND BIODEGRADABLE STENTS
Authors: C Robles-Medranda, R Oleas, M Puga-Tejada, J Alcivar-Vasquez, H Pitanga-Lukashok
Journal: Endoscopy (2020)

Aims To evaluate the safety and efficacy of fully covered self-expandable esophageal metallic stent (FCSEMS) and biodegradable stent in the management of complex esophageal strictures and postsurgical stenosis.
DIRECT ORAL ANTICOAGULANTS IN ACUTE UPPER GI BLEEDING – WHAT IS THE IMPACT ON ENDOSCOPY EFFICIENCY?
Authors: R Patel, KM Ang, S Moledina, R Cama, K Besherdas
Journal: Endoscopy (2020)

Aims Acute upper GI bleeding (AUGIB) is a common medical emergency with 10% mortality. Direct oral anticoagulants (DOACs) are associated with an increased risk of AUGIB but the length of stay, re-bleed risk and mortality following a bleed has not been fully ascertained We aimed to compare the influence of DOACs on factors affecting endoscopy and post-endoscopy outcomes.
Ivosidenib in IDH1-mutant, chemotherapy-refractory cholangiocarcinoma (ClarIDHy): a multicentre, randomised, double-blind, placebo-controlled, phase 3 study
Authors: Ghassan K Abou-Alfa, Teresa Macarulla, Milind M Javle, Robin K Kelley, Sam J Lubner, Jorge Adeva, James M Cleary, Daniel V Catenacci, Mitesh J Borad, John Bridgewater, William P Harris, Adrian G Murphy, Do-Youn Oh, Jonathan Whisenant, Maeve A Lowery, Lipika Goyal, Rachna T Shroff, Anthony B El-Khoueiry, Bin Fan, Bin Wu, Christina X Chamberlain, Liewen Jiang, Camelia Gliser, Shuchi S Pandya, Juan W Valle, Andrew X Zhu
Journal: The Lancet Oncology (2020)
A RETROSPECTIVE REVIEW TO COMPARE THE VALUE OF PANCREATIC CYST FLUID ANALYSIS AT EUS WITH POST-OPERATIVE HISTOLOGY
Authors: G Mellotte, V Parihar, N Breslin, K Conlon, P Ridgway, BM Ryan
Journal: Endoscopy (2020)

Aims To assess clinical value of EUS-guided pancreatic cystic lesion FNA performed in TUH from 2012-2019.
Abstract 15849: Early Increases in Biomarkers Predict Subsequent Cardiotoxicity in Breast Cancer Patients Treated With Doxorubicin, Taxanes, and Trastuzumab
Authors: Mary Putt, Bonnie Ky, Heloisa Sawaya, Benjamin French, James L Januzzi, Igal Sebag, Juan Planas, Victor Cohen, Jose Blanchs, Joseph Carver, Susan Wiegers, Randolph P Martin, Michael Picard, Robert Gerstzen, Elkan Halpern, Jonathan Passeri, Kuter Irene, Marielle Scherrer-Crosbie
Journal: Circulation (2013)

Background: Current methods inadequately identify breast cancer patients at risk of cardiotoxicity with chemotherapy. We asked whether baseline levels, early changes, or biomarker combinations pred...
Muscle–Organ Crosstalk: The Emerging Roles of Myokines
Authors: Mai Charlotte Krogh Severinsen, Bente Klarlund Pedersen
Journal: Endocrine Reviews (2020)

Abstract Physical activity decreases the risk of a network of diseases, and exercise may be prescribed as medicine for lifestyle-related disorders such as type 2 diabetes, dementia, cardiovascular diseases, and cancer. During the past couple of decades, it has been apparent that skeletal muscle works as an endocrine organ, which can produce and secrete hundreds of myokines that exert their effects in either autocrine, paracrine, or endocrine manners. Recent advances show that skeletal muscle produces myokines in response to exercise, which allow for crosstalk between the muscle and other organs, including brain, adipose tissue, bone, liver, gut, pancreas, vascular bed, and skin, as well as communication within the muscle itself. Although only few myokines have been allocated to a specific function in humans, it has been identified that the biological roles of myokines include effects on, for example, cognition, lipid and glucose metabolism, browning of white fat, bone formation, endothelial cell function, hypertrophy, skin structure, and tumor growth. This suggests that myokines may be useful biomarkers for monitoring exercise prescription for people with, for example, cancer, diabetes, or neurodegenerative diseases.
HIGH CLEANSING EFFICACY WITH OVERNIGHT SPLIT DOSING 1 L NER1006 IN BOTH MEN AND WOMEN: POST HOC ANALYSIS OF TWO RANDOMISED PHASE 3 CLINICAL TRIALS
Authors: J Manning, L Clayton, MA Alvarez-Gonzalez
Journal: Endoscopy (2020)

Aims We compared, per gender, the cleansing performance of 1 L polyethylene glycol NER1006 (PLENVU) versus two preparations.
MicroRNA-628-5p Facilitates Enterovirus 71 Infection by Suppressing TRAF3 Signaling
Authors: Dong Li, Shuaiyin Chen, Weiguo Zhang, Chao Zhang, Tiantian Sun, Yue Du, Ronghua Ding, Yanlei Gao, Yuefei Jin, Guangcai Duan
Journal: Cellular and Molecular Immunology (2020)
SPYGLASS CHOLANGIOSCOPY AND SPYBASKET FOR THE REMOVAL OF A POST-CHOLECYSTECTOMY SURGICAL CLIP FROM THE BILE DUCT
Authors: T El Menabawey, H Martin, C Parisinos, G Webster
Journal: Endoscopy (2020)

A 56 year-old female had a cholecystectomy for calculi in 2010. She re-presented in 2018 with recurrent right upper quadrant pain. A CT performed demonstrated a surgical clip within the bile duct. An ERCP with sphinterotomy and sphincteroplasty was performed but the clip could not be cleared with balloon trawl. SpyGlass cholangioscopy was performed and using SpyBasket the clip was removed under direct vision.
Prediction Of Health-Related Quality Of Life (hrql) Over Time In Patients With Chronic Obstructive Pulmonary Disease (COPD) In Primary Healthcare
Authors: L Siebeling, Z J Musoro, R B Geskus, M Zoller, P Muggensturm, A Frei, M A Puhan, G Ter Riet
Journal: American Journal of Respiratory and Critical Care Medicine (2013)
A STEEP EARLY LEARNING CURVE FOR ENDOSCOPIC SUBMUCOSAL DISSECTION (ESD) IN THE LIVE PORCINE MODEL
Authors: RK Magalhães, M Dinis-Ribeiro, MJ Bruno, R Marcos-Pinto, C Rolanda, AD Koch
Journal: Endoscopy (2020)

Aims Endoscopic Submucosal Dissection (ESD) is a demanding procedure requiring high level of expertise. ESD training programs incorporate procedures with live animal models. This study aimed to assess the early learning curve for performing ESD on live porcine models by endoscopists without any or limited previous ESD experience.
In unprotected left main CAD, revascularization with PCI and DES increased risk for MACCE vs CABG at 5 years
Authors: Saraschandra Vallabhajosyula, Malcolm R. Bell
Journal: Annals of Internal Medicine (2020)

Holm NR, Mäkikallio T, Lindsay MM, et al. Percutaneous coronary angioplasty versus coronary artery bypass grafting in the treatment of unprotected left main stenosis: updated 5-year outcomes from the randomised, non-inferiority NOBLE trial. Lancet. 2019;395:191-9. 31879028.
“I knew that I wasn’t cis, I knew that, but I didn’t know exactly”: Gender identity development, expression and affirmation in youth who access gender affirming medical care
Authors: Annie Pullen Sansfaçon, Denise Medico, Frank Suerich-Gulick, Julia Temple Newhook
Journal: International Journal of Transgender Health (2020)

Background: Research about gender identity development is still in its infancy, especially among youth who experience gender dysphoria and are accessing gender-affirming medical care.Aims: This article contributes to the literature on how gender identity and gender dysphoria is experienced, expressed and addressed by youth who have started, or are just about to start, a gender-affirming medical intervention.Methods: The project draws from qualitative interviews with 36 trans children and youth of different ages and stages of puberty. The data were collected in three specialized Canadian clinics that offer gender-affirming care and they were analyzed through inductive thematic analysis.Results: Two interlinked dimensions of the youth’s lives allow meaning-making of their gender identity: 1) internal or personal and 2) interactional or social processes. Careful analysis reveals three gender identity development pathways that may be taken by youth, from early questioning to the affirmation of their gender identity. A discussion of current models of gender identity development and their limitations concludes the article.
A phase I/IIa study of IMCgp100: Partial and complete durable responses with a novel first-in-class immunotherapy for advanced melanoma
Authors: M R Middleton, P Corrie, M Sznol, J Infante, C Mulatero, J Evans, N Steven, D Krige, W H Shingler, Y McGrath, N J Hassan, B K Jakobsen
Journal: Cancer Research (2015)
CLINICOPATHOLOGICAL CHARACTERIZATION AND SURVIVAL OUTCOME OF EARLY ONSET COLORECTAL CANCER IN THE LAST 30 YEARS IN THE NETHERLANDS
Authors: FER Vuik, SAV Nieuwenburg, I Nagtegaal, EJ Kuipers, MCW Spaander
Journal: Endoscopy (2020)

Aims Colorectal cancer (CRC) incidence is increasing in young adults. Most of the early-onset CRC (EOCRC) are sporadic. Little is known about the clinicopathological characteristics of sporadic EOCRC. To identity features unique to EOCRC, we evaluated clinicopathological characteristics and survival outcome in EORCT patients in the Netherlands within the last 30 years.
INITIAL EXPERIENCE WITH PER-RECTAL ENDOSCOPIC MYOTOMY (PREM) FOR HIRSCHSPRUNG’S DISEASE: LONG-TERM OUTCOMES OF THE FIRST CASE SERIES OF A NOVEL THIRD SPACE ENDOSCOPIC PROCEDURE
Authors: P Dashatwar, A Bapaye, S Dharamsi, S Biradar, V Biradar, R Pujari
Journal: Endoscopy (2020)

Aims Per-rectal endoscopic myotomy (PREM) has been recently described as a minimally invasive treatment for Hirschsprung’s Disease (HD). This case-series reports safety and long-term outcomes after PREM.
Circulating BMP9 Protects the Pulmonary Endothelium during Inflammation-induced Lung Injury in Mice
Authors: Wei Li, Lu Long, Xudong Yang, Zhen Tong, Mark Southwood, Ross King, Paola Caruso, Paul D. Upton, Peiran Yang, Geoffrey A. Bocobo, Ivana Nikolic, Angelica Higuera, Richard M. Salmon, He Jiang, Katharine M. Lodge, Kim Hoenderdos, Rebecca M. Baron, Paul B. Yu, Alison M. Condliffe, Charlotte Summers, Sussan Nourshargh, Edwin R. Chilvers, Nicholas W. Morrell
Journal: American Journal of Respiratory and Critical Care Medicine (2020)

Pulmonary endothelial permeability contributes to the high-permeability pulmonary edema that characterizes acute respiratory distress syndrome. Circulating BMP9 (bone morphogenetic protein 9) is emerging as an important regulator of pulmonary vascular homeostasis.
A dietary compound Psoralidin act as a potent “Akt inhibitor” in prostate cancer cells
Authors: Raj Kumar, Sowmyalakshmi Srinivasan, Srinivas Koduru, Firdaus Mardhatillah, Jurgen Rohr, Chendil Damodaran
Journal: Cancer Research (2008)

3384  A protein kinase, Akt plays an important role in cancer cell proliferation andsurvival in many cancers, including prostate cancer. It serves asa nexus in this pathway as a consequence of its ability to inhibit apoptosis and promote angiogenesis in most cell types. In nearly 50% of prostate tumors,Akt signaling is constitutively activated due to the deletionof the tumor suppressor PTEN, which negatively regulates PI3K through (in part) lipid phosphataseactivity. Recently, we have identified a dietary compound, psoralidin, which binds to Akt and inhibits its phosphorylation and kinase activation in androgen independent prostate cancer (AIPC) cells (PC-3 and DU-145). Further, ectopic expression of Akt renders resistant to AIPC cells; however, psoralidin overcomes Akt-mediated resistance and induced apoptosis in AIPC cells. While dissecting the downstream events of Akt, we found that psoralidin transcriptionally repress NFkB activation, and other pro-survival genes (Bcl-2, Survivin and Bcl-XL etc) which results in the inhibition of cell viability and induction of apoptosis in PC-3 and DU-145 cells. Subsequent studies suggest that psoralidin also arrested the cell at G2/M phase of cell cycle by negatively regulating cell cycle regulators Cdc-25B, cyclin D1 and cyclin B1 in AIPC cells. Additionally, in vivo xenograft assays substantiated these in vitro findings and showed that psoralidin inhibits prostate tumor growth in nude mice. Interestingly, our results demonstrate that psoralidin, specifically targets cancer cells without causing significant toxicity to normal prostate epithelial cells. Currently, we are focusing on chemopreventive effect of psoralidin in TRAMP in vivo models. Our studies may advance our understanding of novel strategies in the treatment of AIPC cells, which is still in need for more effective treatment strategies in patients presenting with advanced or metastatic disease.
ENDOSCOPIC MULTIMODAL EXTRA-GASTRIC PANCREATIC NECROSECTOMY: UNUSUAL AND MULTIPLE ACCESS ROUTES (WITH VIDEO CASES)
Authors: J-M Gonzalez, M Gasmi, L Monino, M Barthet
Journal: Endoscopy (2020)

This video showed 4 patients from series of 6 managed for post SAP infected necrosis by EN using multiple accesses, including at least one extra-gastric route (percutaneous, transcolic or transjejunal). The 1st access (median 6 weeks [4-20]) were transgastric (3 patients), trans-duodenal (1pt), and trans-jejunal (1pt), created with LAMS in 4 cases and metal stent in 1 case. The 2nd access for EN (median of 13 weeks [4-22]) was percutaneous in 5 patients and transcolic through LAMS in one