tbuckley/cabot-search huggingface dataset:
Patient-reported satisfaction with reconstructed breasts in the long-term survivorship period: Comparison of autologous and nonautologous breast reconstruction.
Authors: Amie Scott, Adelyn Ho, Anne Klassen, Stefan Cano, Nancy VanLaeken, Peter Cordeiro, Andrea Pusic
Journal: Journal of Clinical Oncology (2012)

9043 Background: Breast cancer patients undergoing mastectomy may choose to have reconstruction performed using either their own tissue or an implant. As many patients are candidates for both, valid and reliable patient-centered outcomes data are crucial to shared medical decision-making. The objective of this study is to determine whether patient-reported satisfaction with their reconstructed breasts is dependent on type of reconstructive surgery and length of time from reconstruction. Methods: Participants were recruited from Memorial Sloan-Kettering Cancer, NY and the University of British Columbia, Canada. Patients completed the BREAST-Q, a new patient-reported outcome measure for breast surgery patients. The dependent variable was the BREAST-Q Satisfaction with Breast score, a 16-item scale scored from 0-100. Procedure type, time since surgery, and patient characteristics were independent variables. Univariate analysis and clinical judgment were used to identify variables included in the model, and multivariate linear regression models were constructed to control for confounders. Results: The study sample consisted of 510 women (response rate 62%). The sample was on average aged 54.3 ± 9.3 (range 21-81), surveyed 3.71 years ± 1.55 (range 1-9) after surgery, 66% were reconstructed using an implant. Type of surgery and laterality were found to be variables that predicted higher patient satisfaction with their breasts after controlling for radiation therapy, follow-up time, timing of surgery, age, body mass index, and major complications (surgery type p&lt;0.001; laterality p&lt;0.001, R-square=0.17). Conclusions: As there is a growing population of breast cancer survivors, understanding how a woman’s satisfaction with her reconstructed breasts changes over time is essential. This study suggests that patient satisfaction with breast reconstruction depends on the type of reconstruction a woman undergoes. This patient-centered outcome data can be used to enhance shared medical decision-making by providing patients with information about realistic expectations for satisfaction with breasts related to type of surgery chosen.
Abstract 17468: Microvascular Remodeling Lesions on Computed Tomography and Their Clinical Impact in Pulmonary Arterial Hypertension
Authors: Virginie F. Tanguay, Camille Babin, Gabrielle Giardetti, Grégoire Ruffenac, Caroline Lambert, David Montani, Olivier Boucherat, Sébastien Bonnet, Steeve Provencher
Journal: Circulation (2017)

Introduction: Pulmonary arterial hypertension (PAH) is a vascular disease characterized by progressive remodeling of the distal pulmonary arteries (PAs). We recently documented that PAH is also cha...
FRI0139 Clinical importance of asymptomatic bacteriuria in women suffer from systemic lupus erythematosus – 5 years observation
Authors: M Koseda-Dragan, M Hebanowski, I Szychlinska, J Galinski
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> Infections are frequent cause of death in lupus patients because of disease depending mechanisms and immunosupressive treatment. Kidneys are often involved in course of lupus. We found asymptomatic bacteriuria in 16,5% women with SLE in first year of our study but longer 5 years observation could help us to understand its clinical importance. <h3>Objectives</h3> Estimation of incidence of asymptomatic bacteriuria (a.b.) in population of women with SLE in 5 years observation. Examination of asymptomatic bacteriuria maintaince in following years of observation. Evaluation of incidence of symptomatic pyelonephritis in SLE women with a.b. Evaluation of need of antibacterial treatment in SLE patients with a.b. <h3>Methods</h3> 85 women aged 24–77(mean 45,2) years with mean SLE duration 10,2 years (2–33) were examined for 5 years. All of them were fulfilling ARA criteria for diagnosis of SLE. We did bacteriological analysis of SLE women urina 5 times in the 5 following years. Patients wereobserved clinically and parameters of biochemical and immunologicalactivity were done. Among group with a.b. were countedwomen whohadsignificant bacteriuria higher than 10<sup>4</sup> in ml urina. Wewere analysing type of bacteria and antibiotic resistancy. <h3>Results</h3> In the following 5 years of observation asymptomatic bacteriuria was found with incidence from 12,8% to 22,5% (mean 17,6%). From 60% to 80% patients with a.b.(mean 70%) eliminated bacteria from urina in period one year without antibacterial treatment. In other patients mean 30% in second urina cultures which was done 1 year after first with a.b., significant bacteriuria was persistent. 50% of women with persistent bacteriuria after one year had in urina the same type of bacteria but in 50% patients type of bacteria was changed. In 5 years only 3 incidence of symptomatic pyelonephritis in SLE women with a.b. was observed. In all 3 cases nephrolithiasis was coexisted with SLE. <h3>Conclusion</h3> Incidence of asymptomatic bacteriuria in women with SLE was 17,6%. 70% patients with a.b. eliminated bacteriuria without antibacterial treatment in one year. In patients with a.b. in course of SLE symptomatic pyelonephritis was no observed (besides patients with nephrolithiasis). Asymptomatic bacteriuria in women with SLE do not need antibacterial treatment.
Possible association of postmeiotic segregation increased 2 (PMS 2) gene deletion and myelodysplastic syndrome.
Authors: Trushil Shah, Gregory James Gerstner, Jaini Sutaria
Journal: Journal of Clinical Oncology (2012)

e17021 Background: Postmeiotic segregation Increased 2 (PMS2) gene is one of the gene family members found in clusters on chromosome 7 involved in DNA mismatch repair. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer and Turcot syndrome. PMS-2 defects are not extensively studied and hence there is still considerable potential to detect new hemato-oncological associations with same. Chromosome 7 defects are the most commonly associated genetic abnormalities associated with myelodysplastic syndrome (MDS). Here, we describe a case of a patient with known PMS 2 gene deletion presenting with early onset MDS. Methods: A 52 year old caucasian female came in to our oncology clinic for evaluation after being diagnosed with DCIS of right breast. She underwent surgical resection followed by tamoxifen and surviellance mamograms. She developed gradual onset of fatigue, prompting follow-up laboratory tests which revealed WBC of 8,600, Hgb of 8.5, MCV of 101, and Plt 383,000. B12, folate, and iron studies were normal. Bone marrow biopsy revealed cellularity 80% and cytogenetics with trisomy 8.This lead to diagnosis of myelodysplastic syndrome, refractory cytopenia with multilineage dysplasia and ringed sideroblasts (RCMD-RS). Patient is currently treated with supportive transfusions after lack of benefit of darbopoietin (baseline epo level 67). Family history is pertinent for a son who died at age 21 from colon cancer and a daughter diagnosed at age 22 with colon cancer, who survives. Her daughter subsequently tested positive for G750 PMS-2 from her father and complete deletion of PMS2 from her mother (our patient). Results: PMS2 gene deletion might predispose patients to MDS. Conclusions: Given the common link with chromosome 7 abnormalities, it is therefore possible that there is an associated increased risk of MDS in PMS-2 patients. While our patient did not have any general abnormalities by karyotype, current assays and general karyotyping are of potentially limited value unless specific mutation points are identified. Therefore, additional evaluations may be necessary to better identify at-risk patients.
Expression of type I insulin-like growth factor receptor (IGF1R) in tamoxifen-resistant cells: Implications for cotargeting of IGF1R and estrogen receptor (ER) in breast cancer.
Authors: Dedra H. Fagan, Ryan R. Uselman, Deepali Sachdev, Douglas Yee
Journal: Journal of Clinical Oncology (2012)

e13590 Background: Crosstalk between the insulin-like growth factor (IGF) and estrogen receptor (ER) systems has been well defined in breast cancer. The majority of anti-IGF1R clinical trials are in estrogen receptor-positive patients who have progressed on prior endocrine therapy; early reports show no benefit for addition of IGF1R inhibitors to endocrine therapy in this setting. Methods: To examine the effectiveness of IGF1R inhibitors, tamoxifen-resistant (TamR) cells were generated in MCF-7L and T47D cells. IGF1R was inhibited by monoclonal antibody (dalotuzumab) or IGF1R/insulin receptor (IR) tyrosine kinase inhibitor (AEW541). Results: TamR cells had diminished levels of IGF1R with unchanged levels of IR. Further, TamR cells failed to respond to IGF-I-induced Akt activation, proliferation, and anchorage-independent growth while retaining responsiveness to both insulin and IGF-II. Dalotuzumab inhibited IGF-I-mediated Akt phosphorylation, proliferation, and anchorage-independent growth in parental cells, but had no effect on TamR cells. AEW541 with equal potency for the IGF1R and IR, inhibited IGF-I-, IGF-II-, and insulin-stimulated Akt phosphorylation, proliferation, and anchorage-independent growth in parental cells. Interestingly, AEW541 also inhibited insulin- and IGF-II-stimulated effects in TamR cells. MCF-7L xenografts from estrogen replete mice were inhibited by dalotuzumab. However, dalotuzumab add no additional benefit to tamoxifen in estrogen depleted mice. Xenograft tumors from tamoxifen treated mice had reduced levels of IGF1R mRNA. Conclusions: Because ER regulates IGF1R mRNA expression, inhibition of IGF1R does not add to tamoxifen growth inhibition of breast cancer cells. Furthermore, inhibition of IR may be necessary to manage tamoxifen resistant breast cancer. The failure of clinical trials of IGF1R inhibitors in endocrine resistant breast cancer could be explained by this crosstalk between the two growth regulatory receptors.
Conversion, Compromise, and Conversation—Moving to a Sensible Middle When Addressing Implantable Cardioverter-Defibrillator Therapy—Reply
Authors: Daniel B. Kramer, Alfred E. Buxton, Peter J. Zimetbaum
Journal: JAMA Cardiology (2019)

In Reply We thank Gimbel and Wilkoff for their interest in our Viewpoint.1 Their letter highlights 2 interesting aspects of managing patients with implantable cardioverter-defibrillators (ICDs) as their goals evolve over time.
Effect of integrated nutrient management (INM) modules on late sown Indian mustard [B. juncea (L.) Cernj. Cosson] and soil properties
Authors: H. Singh, R. P. Singh, B. P. Meena, B. Lal, M. L. Dotaniya, A. O. Shirale, K. Kumar
Journal: Journal of Clinical Oncology (2018)

A field experiment was conducted to assess the effect of integrated nutrient management (INM) modules on yield and soil properties in late sown Indian mustard [Brassica juncea (L.) Czernj. & Cosson.]. In this study, 16 INM module combinations of organic (Farm yard manure and vermicompost), inorganic and biofertilizers were used. The experiment was laid out in randomized block design (RBD) with three replications. The numbers of secondary branches were conspicuously higher than primary and tertiary branches and these also bear higher number of siliquae/branch. The contribution of secondary branches was highest in seed yield of mustard. Integrated use of 100% recommended fertilizer dose (RDF) along with organic sources of nutrients resulted in significantly higher number of branches/plant, siliqua/branch, seeds/siliquae and seed yield of mustard as compared to application of 100% RDF (NPK) alone. The total N, P and K uptake by the crop ranged between 76.1 kg/ha in control and 187.2 kg/ha in 100% recommended dose of fertilizers (RDF) + FYM 5 t/ha + vermicompost (VC) 2.5 t/ha + Azotobacter. Integration of inorganic and organic sources of nutrients improved the soil organic carbon (SOC) content, availability of soil nutrient status (N, P and K), microbial biomass carbon (MBC) and dehydrogenase activity (DHA) in soil, whereas the use of chemical fertilizer alone showed a pronounced decline of these parameters.

	Key words: Integrated nutrient management, Indian mustard, seed yield, oil content, soil health.
68Ga-PSMA Uptake in Escherichia coli Spondylodiscitis
Authors: Søren Klingenberg, Mads Ryø Jochumsen, Bodil Ginnerup Pedersen, Kirsten Bouchelouche
Journal: Clinical Nuclear Medicine (2019)

In a patient with recently diagnosed intermediate-risk prostate cancer, Ga-prostate-specific-membrane-antigen (PSMA) PET/CT for primary staging discovered increased Ga-PSMA uptake in spondylodiscitis in the thoracic spine. The bacteria Escherichia coli was found both in blood cultures and bone biopsies from the thoracic lesion. This case presents spondylodiscitis as a potential benign pitfall to be aware of when interpreting PSMA PET/CT in prostate cancer patients.
Response to: ‘Response to: ‘Alcohol is not the missing link between <i>Porphyromonas gingivalis</i> related periodontitis and radiologic progression in early Rheumatoid arthritis’ by Hillion <i>et al</i>’ by Marotte and Paul
Authors: Alexandre Bellier, Xavier Romand, Athan Baillet
Journal: Annals of the Rheumatic Diseases (2019)

Response to: 'Response to: 'Alcohol is not the missing link between Porphyromonas gingivalis related periodontitis
Abstract 17827: Outcome Prediction after Percutaneous Mitral Valvuloplasty: Improvements to Echocardiographic Score Based on Mechanistic Insights
Authors: Maria P Nunes, Timothy C Tan, Sammy Elmariah, Luis M Rincon, Rodrigo d Lago, Ronan Margey, Ignacio Cruz-Gonzalez, Hui Zheng, Mark D Handschumacher, Ignacio Inglessis, Igor F Palacios, Arthur E Weyman, Judy Hung
Journal: Circulation (2012)

Current echo scoring system for percutaneous mitral valvuloplasty (PMV) has limitations in that it does not incorporate commissural morphology which is a fundamental remodeling process in rheumatic...
Effects of rhIL-7 administration in humans on in vivo expansion of naïve, memory and effector subsets of CD4+ & CD8+ T-cells
Authors: C. Sportes, F. Hakim, M. Krumlauf, R. Babb, T. Fleisher, M. Brown, J. Engel, R. Buffet, C. Mackall, R. Gress
Journal: Journal of Clinical Oncology (2006)

2504 Background: IL-7 has a critical and non-redundant role in T-cell lymphopoiesis and peripheral T-cell homeostasis. IL-7 administration may prove clinically valuable in conditions of disease induced (HIV) or iatrogenic T-cell depletion and for modulation of vaccine immune responses. In the first phase I study in humans, recombinant human interleukin-7 (“CYT 99–007”, Cytheris Inc., Rockville, MD) was administered subcutaneously every other day for two weeks in adults with refractory malignancies at 3, 10, 30 and 60 μg/kg/dose. Biologic activity, defined as a 50% increase over baseline of peripheral blood CD3+ T-cells, was seen at and above the 10μg/kg/dose in all patients. The kinetics of proliferation and expansion of peripheral blood T-cell subsets were analyzed. Methods: Multicolor flow cytometry was performed at baseline, 1, 2 and 3 weeks. Among CD4+ cells, the most naïve were defined as CD45RA+ /CD31+. Among CD4+ &amp; CD8+ cells, the main naïve, memory and effector populations were defined respectively as CD45RA+/CD27+, CD45RA-/CD27+ and CD45RA-/CD27-. Within each subset, the number of cells in cycle was defined by Ki67 staining. Results: Following IL-7 therapy, there was marked proliferation of all T-cells subsets, peaking at week 1, most striking for the naive subsets with 30–70% of circulating cells induced to cycle. Proliferation rates were halved by week 2 despite continuation of treatment, coincident with the observed down-regulation of the IL-7 receptor. Cycling returned to baseline by week 3. Significant proliferation was also induced in effector and memory CD4+ and CD8+ T-cells but to a lesser magnitude, resulting in a greater net expansion of the naïve subsets, still ongoing one week after the end of treatment. Conclusions: IL-7 administration induces marked expansion of naïve, memory and effector CD4+ &amp; CD8+ T-cells in humans. Consistent with the known down-regulation of the IL-7 receptor upon IL-7 exposure, proliferation rates decrease during the second week of treatment. rhIL-7 induced T-cell expansion may prove clinically valuable in adoptive immunotherapy as an adjunct to tumor vaccination and / or immunorestorative agent. [Table: see text]
Neoadjuvant cetuximab, capecitabine, and radiotherapy (RT) in locally advanced resectable rectal cancer: results of a phase II trial
Authors: V. Velenik, J. Ocvirk, I. Oblak, F. Anderluh
Journal: Journal of Clinical Oncology (2009)

e15029 Background: Preoperative chemoradiotherapy (CRT) with capecitabine is a treatment of choice for locally advanced rectal cancer. The radiosensitizing effect of cetuximab, an EGFR-targeting monoclonal antibody, may further enhance the tumor response. The aim of this prospective, nonrandomized, open-label phase II study was to establish the efficacy and safety profile of cetuximab combined with capecitabine and concurrent RT for locally advanced resectable rectal cancer. Methods: Patients (pts) with stage II or III rectal cancer confirmed by MRI were treated with capecitabine 1250 mg/m 2 twice daily for 2 weeks. Cetuximab 400mg/m 2 was intravenously administered on week 3, followed by cetuximab 250mg/m 2 /week and capecitabine 825 mg/m 2 bid including weekends during RT. The RT dose was 45 Gy (25×1.8 Gy, 3D conformal technique), starting on week 4. Total mesorectal excision was scheduled 4–6 weeks after completion of CRT. Tumor regression grades (TRG) were evaluated on surgical specimens according to Dworak. The primary endpoint was complete pathologic response (pCR). Results: Thirty-seven pts were eligible for safety and efficacy analyses. Median age was 55 (range: 33–72) years, 81% of pts were male. Three pts (8.1%) had T3N0 tumors, 1 pt (2.7%) T2N1, 13 pts (35%) T3N1, 1 pt (2.7%) T2N2, 15 pts (40.5%) T3N2 and 4 pts (11%) T4N2. The median tumor distance from anal verge was 6 (range: 1–11) cm. All pts received 45 Gy RT. Dose reduction/treatment interruption was necessary for 9/37 (24.3%) pts owing to hypersensitivity reaction (n=4), hepatotoxicity grade 3 (n=1) or diarrhea grade 3 (n=4). Other grade 3 toxicities included dermatitis (n=6, 16.2%), anorexia (n=1, 2.7%) and infection (n=1, 2.7%). TRG 4 (pCR) was recorded in 3 pts (8.1%) and TRG 3 in 7 pts (18.9%). T-, N- and overall downstaging rates were 56.8%, 81.1% and 73.0%, respectively. The total sphincter preservation rate was 75.7%; in 17 pts whose tumors were located ≤5 cm of the anal verge, the rate was 53%. Conclusions: Preoperative CRT with cetuximab and capecitabine is safe and feasible. A high pathologic downstaging rate was achieved, although the pCR rate appeared to be in the range previously reported for CRT with capecitabine. No significant financial relationships to disclose.
Representation of older adults in randomized controlled trials on systemic treatment in plaque psoriasis: A systematic review
Authors: Mirjam J. Schaap, Marieke E.C. van Winden, Marieke M.B. Seyger, Elke M.G.J. de Jong, Satish F.K. Lubeek
Journal: Journal of the American Academy of Dermatology (2019)
Racial Differences Influence Bariatric Surgery Outcomes
Authors: Nicole Ellen James, Jhia J. Teh, Wenyi Cai
Journal: JAMA Surgery (2019)

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Abstract P248: Assessing for Bi-Directional Relationships between Body Mass Index and Mental Health Symptoms in Girls
Authors: Kathleen M McTigue, Elan Cohen, Alison Hipwell, Charity Moore, Rolf Loeber, Lewis H Kuller
Journal: Circulation (2013)

Introduction Obesity and mental health problems are increasing in youth; both are often under-treated. The interplay between mental health and body weight development in adolescent girls is not well understood. Hypothesis Bi-directional associations will be established between mental health symptoms (depression and conduct symptoms) and BMI in urban pre-adolescent girls. Methods We examined data from participants in an accelerated longitudinal cohort study of largely disadvantaged urban girls from a single US city (n=2,451; 53% African American). Data were collected annually over 6 years, starting in 2003 when girls were age 8-11. Depression and conduct symptoms (oppositional defiant disorder and conduct disorder symptoms combined) were collected via the validated Child Symptom Inventory (CSI-4) and height and weight were measured. Transitional models assessed for bi-directional associations between mental health symptoms and BMI. Random-effects mixed models identified within-subject and between-subject effects in models examining whether mental health symptoms predicted BMI. All models were adjusted for race, age, and receipt of public assistance, and when applicable, included interaction terms. Results Transitional models showed that prior depression symptoms (β=0.27; p&lt;0.001) predicted an increase in BMI while prior conduct symptoms (β=0.04; p=0.05) showed a small and borderline significant effect on BMI. An increase in prior BMI predicted an increase in depression symptoms (β=0.074, p&lt;0.001) but not conduct symptoms (β=0.028, p=0.125). Mixed models revealed significant between-girl and within-girl effects (β = 0.38 and 0.038, respectively, both with p&lt;0.001) for depression symptoms predicting BMI. Conduct symptoms showed a significant between-girl effect (β=0.51; p=0.045) but a non-significant within-girl effect (β=0.011; p=0.080) when used to predict BMI. Conclusions We identified a clear bi-directional relationship between depression symptoms and BMI in under-privileged girls, and mixed models confirmed that a change in depression score is associated with increased BMI. While an increase in conduct symptoms shows a weak positive association with BMI, the association was not bi-directional. The potential for BMI and depression to each reinforce the other may represent a mechanism for the development of high-risk weight patterns in girls. Early identification of those at risk may facilitate preventive measures for both weight and mental health outcomes.