tbuckley/cabot-search huggingface dataset:
Single-Cell RNA Sequencing Reveals a Developmental Hierarchy in Langerhans Cell Histiocytosis
Authors: Tanja A. Gruber
Journal: Cancer Discovery (2019)

Abstract Summary: In this issue of Cancer Discovery, Halbritter and colleagues utilize single-cell RNA sequencing to dissect the cellular hierarchy in Langerhans cell histiocytosis. They identified a remarkably consistent composition of 14 cellular subsets across all patients with a range of clinical spectrums consistent with a shared developmental hierarchy driven by key transcriptional regulators. See related article by Halbritter et al., p. 1406.
TPX-0046 is a novel and potent RET/SRC inhibitor for RET-driven cancers
Authors: A. Drilon, E. Rogers, D. Zhai, W. Deng, X. Zhang, D. Lee, J. Ung, J. Whitten, H. Zhang, J. Liu, T. Hu, H. Zhuang, Y. Lu, Z. Huang, A. Graber, Z. Zimmerman, R. Xin, J.J. Cui, V. Subbiah
Journal: Annals of Oncology (2019)
Safety and pharmacokinetics of novel CXCR4 antagonist YF-H-2015005 in the mobilization of hematopoietic stem cells in patients with non-Hodgkin’s lymphoma
Authors: W. Liu, Y. Xie, L. Ping, M. Jiang, G. Zhang, Y. Cui, J. Xu, M. Wu, X. Leng, X. Wang, S. Wang, G. Zhang, J. Zhu, Y. Song
Journal: Annals of Oncology (2019)
An Activatable Near-Infrared Chromophore for Multispectral Optoacoustic Imaging of Tumor Hypoxia and for Tumor Inhibition
Authors: Jing Huang, Yinglong Wu, Fang Zeng, Shuizhu Wu
Journal: Theranostics (2019)

Hypoxia is a key hallmark of solid tumors and tumor hypoxia usually contributes to cancer progression, therapeutic resistance and poor outcome. Accurately detecting and imaging tumor hypoxia with high spatial resolution would be conducive to formulating optimized treatment plan and thus achieving better patient outcome. Methods: Tumor hypoxia can cleave the azo linker and release a NIR fluorophore (NR-NH2) and release the active drug as well. NR-NH2 shows a strong absorption band at around 680 nm and a strong fluorescence band at 710 nm, allowing for both multispectral optoacoustic tomography imaging (MSOT) and fluorescent imaging of tumor hypoxia in a tumor-bearing mouse model. Results: Liposome encapsulated with the activatable chromophore (NR-azo) for detecting/imaging tumor hypoxia and for tumor inhibition was demonstrated. For this chromophore, a xanthene-based NIR fluorophore acts as the optoacoustic and fluorescent reporter, an azo linker serves as the hypoxia-responsive moiety and a nitrogen mustard as the therapeutic drug. NR-azo shows an absorption at around 575 nm but exhibits negligible fluorescence due to the existence of the strong electron-withdrawing azo linker. Conclusion: We demonstrated an optoacoustic and fluorescent system for not only imaging tumor hypoxia in vivo but also achieving tumor inhibition.
Chemokines expressed in melanoma metastases associated with T cell infiltration
Authors: T. Gajewski, Y. Meng, H. Harlin
Journal: Journal of Clinical Oncology (2007)

8501 Background: Despite frequent induction of tumor antigen-specific T cells in melanoma patients following vaccination, tumor regressions remain rare. This observation prompted systematic analysis of the melanoma tumor microenvironment to identify factors that may influence the effector phase of the anti-tumor immune response. Methods: Gene expression profiling using the Affymetrix platform was performed on a series of melanoma metastases, melanoma cell lines, and primary melanocyte cell lines. Confirmatory assays were done by real-time RT-PCR, protein array, immunohistochemistry (IHC), and in vitro chemokine migration assays. Results: Non- supervised hierarchical clustering revealed 3 major subsets of tumors, with the main clustering based on differential expression of T cell-derived transcripts. The presence of CD8 + T cells was confirmed by IHC. Tumors that contained T cells uniquely expressed high levels of multiple chemokines. Protein array confirmed high expression of CCL2, CCL4, and CCL5; real-time RT-PCR additionally confirmed relatively high levels of CXCL9, CXCL10, and CCL3 transcripts. Transwell assays confirmed that each of these 6 chemokines recruited CD8 + effector cells in vitro. Conclusions: We have identified a set of 6 chemokines that likely regulates recruitment of activated T cells into melanoma metastases. Tumors that lack such chemokines might not be capable of supporting the effector phase of the anti-tumor immune response. We suggest that chemokine profiling of tumor sites should be performed in clinical trials of active immunotherapy. No significant financial relationships to disclose.
Phase III ALTA-3 study of brigatinib (BRG) vs alectinib (ALC) in patients (pts) with advanced anaplastic lymphoma kinase (ALK)−positive non–small cell lung cancer (NSCLC) that progressed on crizotinib (CRZ)
Authors: S. Popat, G. Liu, S. Lu, G. Song, V. Samnotra, J C-H Yang
Journal: Annals of Oncology (2019)
High-density lipoprotein remodelled in hypercholesterolaemic blood induce epigenetically driven down-regulation of endothelial HIF-1α expression in a preclinical animal model
Authors: Soumaya Ben-Aicha, Rafael Escate, Laura Casaní, Teresa Padró, Esther Peña, Gemma Arderiu, Guiomar Mendieta, Lina Badimón, Gemma Vilahur
Journal: Cardiovascular Research (2019)

Abstract Aims High-density lipoproteins (HDLs) are circulating micelles that transport proteins, lipids, and miRNAs. HDL-transported miRNAs (HDL-miRNAs) have lately received attention but their effects on vascular cells are not fully understood. Additionally, whether cardiovascular risk factors affect HDL-miRNAs levels and miRNA transfer to recipient cells remains equally poorly known. Here, we have investigated the changes induced by hypercholesterolaemia on HDL-miRNA levels and its effect on recipient endothelial cells (ECs). Methods and results Pigs were kept on a high-fat diet (HC; n = 10) or a normocholesterolaemic chow (NC; n = 10) for 10 days reaching cholesterol levels of 321.0 (229.7–378.5) mg/dL and 74.0 (62.5–80.2) mg/dL, respectively. HDL particles were isolated, purified, and quantified. HDL-miRNA profiling (n = 149 miRNAs) of HC- and NC-HDLs was performed by multipanel qPCR. Cell cultures of porcine aortic ECs were used to determine whether HDL-miRNAs were delivered to ECs. Potential target genes modulated by miRNAs were identified by bioinformatics and candidate miRNAs were validated by molecular analysis. In vivo effects in the coronary arteries of normocholesterolaemic swine administered HC- or NC-HDLs were analysed. Among the HDL-miRNAs, four were found in different amounts in HC- and NC-HDL (P &amp;lt; 0.05). miR-126-5p and -3p and miR-30b-5p (2.7×, 1.7×, and 1.3×, respectively) were found in higher levels and miR-103a-3p and miR-let-7g-5p (−1.6×, −1.4×, respectively) in lower levels in HC-HDL. miR-126-5p and -3p were transferred from HC-HDL to EC (2.5×; P &amp;lt; 0.05), but not from NC-HDL, by a SRB1-mediated mechanism. Bioinformatics revealed that HIF1α was the miR-126 target gene with the highest predictive value, which was accordingly found to be markedly reduced in HC-HDL-treated ECs and in miR126 mimic transfected ECs. In vivo validation confirmed that HIF1α was diminished in the coronary endothelial layer of NC pigs administered HC-HDL vs. those administered NC-HDL (P &amp;lt; 0.05). Conclusion Hypercholesterolaemia induces changes in the miRNA content of HDL enhancing miR126 and its delivery to ECs with the consequent down-regulation of its target gene HIF1α.
Abstract 9950: Altered Expression of Trpv1 and Sensitivity to Capsaicin in Aortic Baroreceptor Neurons in Diabetic Rats
Authors: Qi Zhang, Yingying Tan
Journal: Circulation (2011)

It has been well documented that diabetes mellitus is associated with cardiovascular autonomic neuropathy including dysfunction of arterial baroreflex. The mechanisms underlying diabetes-induced baroreflex dysfunction remain poorly understood. Previous studies demonstrate an important role of transient receptor potential vanilloid 1 (TRPV1) receptor in painful neuropathy. Here we investigated the function and expression of TRPV1 in aortic baroreceptor (AB) neurons isolated from streptozotocin-induced diabetic rats between 4 and 8 weeks after onset of diabetes. AB neurons in nodose ganglion were retrograde-labeled by a transported fluorescent dye, Dil. Using the whole-cell patch clamp technique, we found that the inward current activated by the application of capsaicin (1 µM) was significantly smaller in AB neurons from diabetic rats compared with controls. The mean peak current density of capsaicin-induced currents was 145.7 ± 24.7 pA/pF (n = 16) in diabetic neurons and 269.3 ± 31.8 pA/pF (n =15) in controls, respectively. The duration of inward current was decreased 51% in diabetic rats compared with the control group. These evoked currents were completely blocked by the capsaicin antagonist capsazepine. In addition, capsaicin-induced desensitization of TRPV1 was up-regulated, whereas TRPV1 re-sensitization was down-regulated in AB neurons from diabetic rats. Immunofluorescence staining studies demonstrated that the percentage of TRPV1-positive neurons was 50.2 ± 5.0% in control rats and 38.2 ± 1.9% in diabetic rats, respectively. This reduction in TRPV1-positive neurons in AB neurons in diabetic rats was significant (n = 11, p &lt; 0.01). These results suggest that reduced expression and function of TRPV1 are involved in the attenuation of baroreceptor neuron excitability, which subsequently contributes to the impairment of baroreflex in diabetes state.
Progesterone receptor isoform ratio dictates antiprogestins/progestins effects on metastatic breast cancer models
Authors: M.F. Abascal, S. Giulianelli, M. Alvarez, G. Sequeira, S. Vanzulli, A. Elia, G. Pataccini, M. Lombes, C. Lanari
Journal: Annals of Oncology (2019)
An Unbiased Proteomics Method to Assess the Maturation of Human Pluripotent Stem Cell–Derived Cardiomyocytes
Authors: Wenxuan Cai, Jianhua Zhang, Willem J. de Lange, Zachery R. Gregorich, Hannah Karp, Emily T. Farrell, Stanford D. Mitchell, Trisha Tucholski, Ziqing Lin, Mitch Biermann, Sean J. McIlwain, J. Carter Ralphe, Timothy J. Kamp, Ying Ge
Journal: Circulation Research (2019)

Human pluripotent stem cell (hPSC)-derived cardiomyocytes exhibit the properties of fetal cardiomyocytes, which limits their applications. Various methods have been used to promote maturation of hPSC-cardiomyocytes; however, there is a lack of an unbiased and comprehensive method for accurate assessment of the maturity of hPSC-cardiomyocytes.
Preselecting tumour-infiltrating lymphocyte subsets to implement adoptive immunotherapy in ovarian cancer
Authors: D. Salas-Benito, C. De Andrea, J.M. Aramendia, U. Mancheño, E. Elizalde, E. Conde, I. Tamayo, F. Guillén, M. Jurado, J Á Mínguez, A González Martín, M. Ponz-Sarvise, S. Hervás-Stubbs
Journal: Annals of Oncology (2019)
Final PFS, updated OS and safety data from the randomised, phase III ALEX study of alectinib (ALC) versus crizotinib (CRZ) in untreated advanced ALK+ NSCLC
Authors: T.S.K. Mok, A.T. Shaw, R.D. Camidge, S.M. Gadgeel, R. Rosell, R. Dziadziuszko, D.-W. Kim, M. Perol, S.-H. Ou, W. Bordogna, V. Smoljanović, M. Hilton, S. Peters
Journal: Annals of Oncology (2019)
Randomized phase III ANGEL study of rivoceranib (apatinib) + best supportive care (BSC) vs placebo + BSC in patients with advanced/metastatic gastric cancer who failed ≥2 prior chemotherapy regimens
Authors: Y.-K. Kang, W.K. Kang, M. Di Bartolomeo, I. Chau, H.H. Yoon, S. Cascinu, M.-H. Ryu, J.G. Kim, K.-W. Lee, S.C. Oh, A. Takashima, A. Kryzhanivska, Y. Chao, V. Vladimirov, L. Evesque, M. Schenker, A. McGinn, N. Sankar, L. Wyrwicz, N. Boku
Journal: Annals of Oncology (2019)
Comprehensive genomic profiling (CGP) of gall bladder adenocarcinoma (GBAC) in patients from distinct ancestral populations
Authors: M. Javle, S. Akumalla, R. Madison, A. Verma, R. Abdel-Wahab, J. Newburg, B.M. Alexander, J. Chung, V.A. Miller, J. Lee, J.S. Ross, A.B. Schrock, G.M. Frampton, S.M. Ali
Journal: Annals of Oncology (2019)
Establishment of Induced Pluripotent Stem Cells from Lymph Node B Cells and Induction of Aid Expression in Their Differentiation into Hematopoietic Stem Cells
Authors: Fumihiko Kawamura, Inaki Makoto, Atsushi Katafuchi, Yu Abe, Naohiro Tsuyama, Yumiko Kurosu, Aki Yanagi, Mitsunori Higuchi, Satoshi Muto, Takumi Yamamura, Hiroyuki Suzuki, Hideyoshi Noji, Shinichi Suzuki, Mitsuaki A Yoshida, Megumi Sasatani, Kenji Kamiya, Masafumi Onodera, Akira Sakai
Journal: Blood (2016)
Triple blockade of EGFR, MEK and PD-L1 as effective antitumor treatment in PD-L1 overexpressing, MEK inhibitor resistant colon cancer cells
Authors: N. Matrone, S. Napolitano, V. Belli, G. Barra, E.F. Giunta, V. De Falco, M. Terminiello, P.P. Vitiello, D. Ciardiello, M. Turano, M. Furia, A.S. Muddassir, S. Kopetz, E. Martinelli, F. Ciardiello, T. Troiani
Journal: Annals of Oncology (2019)
Reply letter to the commentary on “Is strict adherence to the nonoperative management protocol associated with better outcome in patients with blunt splenic injuries?: A retrospective comparative cross-sectional study” Int J Surg 2019;69:116-123
Authors: Ting-Min Hsieh, Chun-Ting Liu, Bei-Yu Wu, Ching-Hua Hsieh
Journal: International Journal of Surgery (2019)
Preclinical evaluation targeting both IGF1R and IR in triple negative breast cancer
Authors: A.J. Eustace, S. Roche, N. Mukherjee, F. O’Neill, N. Conlon, J. Meiller, D.M. Collins, P. Gaule, A. Canonici, S.F. Madden, N. O’Donovan, J. Crown
Journal: Annals of Oncology (2019)
Minimal Residual Disease Assessment May Drive Post Remission Therapy in Acute Myeloid Leukemia. It's Time for MRD-Driven Therapy
Authors: Paola Minetto, Fabio Guolo, Marino Clavio, Annalisa Kunkl, Filippo Ballerini, Nicoletta Colombo, Enrico Carminati, Giuseppina Fugazza, Giordana Pastori, Simona Matarrese, Carmen Di Grazia, Anna Maria Raiola, Andrea Bacigalupo, Roberto Massimo Lemoli, Maurizio Miglino, Marco Gobbi
Journal: Blood (2016)
Atezolizumab in combination with chemotherapy for first-line treatment of advanced non-small cell lung cancer: A systematic review and meta-analysis of randomized controlled trials (RCTs)
Authors: F. Mogollon-Duffo, A. Sultan, S. Swarup, N. Jahan, A.M. Tun, T. Win Htut, T.W. Naing, P.T. Naing, Y. Mon Myat, F. Hardwicke, S. Rehman, L. Tijani, N. D’Cunha, K.Z. Thein
Journal: Annals of Oncology (2019)
Exploring resistance to nivolumab [NIV] applying an Immune Genomic Signature (IGS) in advanced pretreated NSCLC [PRINCiPe study]
Authors: S. Pilotto, E. Vita, I. Sperduti, V P Di Noia, G. Grizzi, E. D’Argento, M. Simbolo, C. Vicentini, A. Caliò, A. Mafficini, L. Carbognin, V. Corbo, A. Gkountakos, A. Santo, M. Brunelli, M. Martini, A. Scarpa, M. Milella, G. Tortora, E. Bria
Journal: Annals of Oncology (2019)
Neutrophils are underrecognized contributors to inflammatory burden and quality of life in chronic rhinosinusitis
Authors: Eric F. Succar, Ping Li, Kim A. Ely, Naweed I. Chowdhury, Rakesh K. Chandra, Justin H. Turner
Journal: Allergy (2019)

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Pioglitazone and clarithromycin combined with metronomic low-dose chemotherapy versus nivolumab in patients with advanced non-small cell lung cancer treated in 2nd-line and beyond: Outcomes from a randomized phase II trial (ModuLung)
Authors: D. Heudobler, C. Schulz, J.R. Fischer, P. Staib, T. Wehler, T. Südhoff, T. Schichtl, J. Wilke, J. Hahn, F. Lüke, M. Vogelhuber, S. Klobuch, T. Pukrop, W. Herr, S. Held, K. Beckers, G. Bouche, A. Reichle
Journal: Annals of Oncology (2019)
Drug holidays and overall survival in patients treated for metastatic colorectal cancer
Authors: S.K. Garattini, M. Bonotto, D. Basile, L. Porcu, E. Ongaro, L. Gerratana, F. Cortiula, G. Pelizzari, A. Parnofiello, E. bertoli, C. Corvaja, C. Lisanti, M. Casagrande, D. Iacono, G.G. Cardellino, A. Buonadonna, G. Aprile, N. Pella, F. Puglisi, G. Fasola
Journal: Annals of Oncology (2019)
Higher Body Mass Index in Adolescence Predicts Cardiomyopathy Risk in Midlife
Authors: Josefina Robertson, Maria Schaufelberger, Martin Lindgren, Martin Adiels, Linus Schiöler, Kjell Torén, John McMurray, Naveed Sattar, Maria Åberg, Annika Rosengren
Journal: Circulation (2019)

Modifiable lifestyle factors in relation to risk for cardiomyopathy, a common and increasing cause of heart failure in the young, have not been widely studied. We sought to investigate a potential link between obesity, a recognized predictor of early heart failure, in adolescence and being diagnosed with cardiomyopathy in adulthood.This was a nationwide register-based prospective cohort study of 1 668 893 adolescent men (mean age, 18.3 years; SD, 0.7 years) who enlisted for compulsory military service from 1969 to 2005. At baseline, body mass index (BMI), blood pressure, and medical disorders were registered, along with test results for fitness and muscle strength. Cardiomyopathy diagnoses were identified from the National Hospital Register and Cause of Death Register during an up to 46-year follow-up and divided into categories: dilated, hypertrophic, alcohol/drug-induced, and other. Hazard ratios were calculated with Cox proportional hazards models.During follow-up (median, 27 years; Q1-Q3, 19-35 years), 4477 cases of cardiomyopathy were identified, of which 2631 (59%) were dilated, 673 (15%) were hypertrophic, and 480 (11%) were alcohol/drug-induced. Increasing BMI was strongly associated with elevated risk of cardiomyopathy, especially dilated, starting at levels considered normal (BMI, 22.5-<25 kg/m2; hazard ratio, 1.38 [95% CI, 1.22-1.57]), adjusted for age, year, center, and baseline comorbidities, and with a >8-fold increased risk at BMI ≥35 kg/m2 compared with BMI of 18.5 to <20 kg/m2. For each 1-unit increase in BMI, similarly adjusted hazard ratios were 1.15 (95% CI, 1.14-1.17) for dilated cardiomyopathy, 1.09 (95% CI, 1.06-1.12) for hypertrophic cardiomyopathy, and 1.10 (1.06-1.13) for alcohol/drug-induced cardiomyopathy.Even mildly elevated body weight in late adolescence may contribute to being diagnosed with cardiomyopathy in adulthood. The already marked importance of weight control in youth is further strengthened by these findings, as well as greater evidence for obesity as a potential important cause of adverse cardiac remodeling that is independent of clinically evident ischemic heart disease.
KEYNOTE-866: Phase III study of perioperative pembrolizumab (pembro) or placebo (pbo) in combination with neoadjuvant chemotherapy in cisplatin (cis)-eligible patients (pts) with muscle-invasive bladder cancer (MIBC)
Authors: A.O. Siefker-Radtke, G. Steinberg, J. Bedke, H. Nishiyama, J. Martin, R. Kataria, T.L. Frenkl, C.J. Hoimes
Journal: Annals of Oncology (2019)
Randomized phase II study of CAPTEM versus FOLFIRI in RAS mutated, MGMT methylated metastatic colorectal cancer (mCRC): Final analysis, tumour biomarkers and methylated ctDNA
Authors: F. Pietrantonio, M. Antista, R. Lobefaro, F. Morano, S. Lonardi, A. Raimondi, S. Murgioni, L. Rimassa, G. Farina, R. Longarini, S. Mosconi, A. Sartore-Bianchi, G. Tomasello, F. Perrone, L. Barault, M. Milione, M. Di Maio, F. Di Nicolantonio, M. Di Bartolomeo, F.G.M. De Braud
Journal: Annals of Oncology (2019)
CXCR4 Monoclonal Antibody, BMS-936564 (MDX-1338), Modulates Epithelial to Mesenchymal Transition (EMT) in Multiple Myeloma Cells
Authors: Aldo M Roccaro, Antonio Sacco, Michelle R. Kuhne, Abdel Kareem Azab, Patricia Maiso, Feda Azab, Salomon Manier, Yosra Aljaway, Michaela R Reagan, Lewis Cohen, Pina M Cardarelli, Irene M. Ghobrial
Journal: Blood (2012)
Abstract 15680: Right Ventricular Diastolic Function in Patients With Pulmonary Hypertension Assessed by Cardiac Magnetic Resonance Imaging Derived Strain Rate Parameters: Correlation With Tau Derived From High-fidelity Micromanometer Catheter Measurement
Authors: Takahiro Sato, Bharath Ambale-Venkatesh, Joao A Lima, Stefan L Zimmerman, Steven Hsu, Ryan J Tedford, David A Kass, Stephen C Mathai, Rachel L Damico, Todd M Kolb, Paul M Hassoun
Journal: Circulation (2016)

Introduction:  Right ventricular (RV) diastolic function (DF) has prognostic significance in patients with pulmonary arterial hypertension (PAH). The aim of this study was to evaluate whether cardiac magnetic resonance imaging (CMRI) derived strain rate (SR) parameters reliably reflect RV DF in PAH using tau derived from high-fidelity micromanometer catheter measurements as a gold standard   Methods:  A total of 19 consecutive patients with PAH, 6 with idiopathic PAH and 13 with scleroderma-associated PAH were studied prospectively. All patients underwent right heart catheterization (RHC) and CMRI which included 4 chamber and axial cine imaging using SSFP within a few hours of each other. SR analysis of longitudinal (Figure A) and circumferential (Figure B) images were performed by Multimodality Tissue Tracking software (version 6.0 Toshiba, Tokyo, Japan). Peak systolic strain rate (SRs), peak early diastolic strain rate (SRe), peak atrial-diastolic strain rate (SRa), and deceleration time of SRe (DT) were obtained from the SR curve (Figure C). Associations between both longitudinal and circumferential SR related parameters and tau were evaluated   Results:  Median age was 57 (48 - 66) years (84.2% women). Median pulmonary artery pressure, pulmonary artery wedge pressure, pulmonary vascular resistance and cardiac index, were 33 (27-49) mmHg, 9 (6 - 11) mmHg, 2.4 (2.1 - 2.6) L/min/m 2 , and 5.5 (4.4-9.0) W.U., respectively consistent with moderate PAH. Longitudinal SRa and DT were significantly correlated with tau (SRa: ρ = -0.63, p = .0039; DT: ρ = 0.77, p = 0.0001). Circumferential SRe, SRa and DT were also significantly correlated with tau (SRe: ρ = -0.49, p = 0.003; SRa: ρ = -0.65, p = 0.004; DT: ρ = 0.78, p = 0.0001)   Conclusions:  Longitudinal and circumferential diastolic SR related parameters obtained by CMRI both detect RV diastolic dysfunction in patients with PAH. Longitudinal and circumferential DT measurements were found to have the best correlation coefficients.
Phase I study of the oncolytic viral immunotherapy agent canerpaturev (C-REV) with S-1 in patients with stage IV pancreatic cancer
Authors: S. Hijioka, M. Ueno, T. Ioka, Y. Hirooka, E. Ohno, T. Okusaka, Y. Maruki, S. Kobayashi, R. Ashida, J. Yashika, J. Furuse, M. Ikeda, H. Kasuya, M. Tanaka, Y. Hashimoto
Journal: Annals of Oncology (2019)
Phase III, international, multicenter, randomized, open-label trial of adjuvant nab-paclitaxel plus gemcitabine (nab-P/G) vs gemcitabine (G) alone for surgically resected pancreatic adenocarcinoma (APACT): Subgroup analyses
Authors: M.A. Tempero, M. Reni, H. Riess, E.M. O’Reilly, S. Krishnamurthi, P. Österlund, I.C. Ales-Diaz, M. Milella, S. Siena, J. Tabernero, E. Van Cutsem, P.A. Philip, D. Goldstein, J.D. Berlin, M. Li, S. Ferrara, Y Le Bruchec, D. McGovern, A. Biankin
Journal: Annals of Oncology (2019)
Eltrombopag for immune thrombocytopenia secondary to chronic lymphoproliferative disorders: a phase 2 multicenter study
Authors: Carlo Visco, Francesco Rodeghiero, Alessandra Romano, Federica Valeri, Michele Merli, Giulia Quaresimini, Stefano Volpetti, Roberto M. Santi, Giuseppe Carli, Elisa Lucchini, Francesco Passamonti, Alessandro Rambaldi, Giovanna Motta, Alessandra Borchiellini, Emanuele S. G. d’Amore, Marco Ruggeri
Journal: Blood (2019)
Survival and prognostic factors of nasopharyngeal cancer patients in non-endemic countries: A large multicentric database analysis
Authors: P. Bossi, S. Grisanti, I. Mohamad, I. Linares Galiana, E. Ozyar, P. Franco, S. Vecchio, L. Livi, B. Cirauqui Cirauqui, M. El-Sherify, S. Ursino, A. Argiris, J. Pan, C. Wittekindt, E. D’angelo, M. Buglione, M. Airoldi, R. Mesia Nin, L.F. Licitra, E. Orlandi
Journal: Annals of Oncology (2019)
High immunoscore is associated with good response to neo-adjuvant chemotherapy and prolonged survival in advanced head and neck cancer patients
Authors: H. Mirghani, C. Mure, B. Mlecnik, F. Hermitte, E. Martel, O. Casiraghi, M. Iacob, C. Even, J. Galon
Journal: Annals of Oncology (2019)