tbuckley/cabot-search huggingface dataset:
THU0132 ASSOCIATION OF RHEUMATOID ARTHRITIS AND DEMENTIA: A NATIONWIDE POPULATION-BASED STUDY
Authors: J. Kim, I. A. Choi, D. H. Yim, H. M. P. Park, S. Y. Eom
Journal: Annals of the Rheumatic Diseases (2020)

Background: Rheumatoid arthritis (RA) and dementia have a mechanism that systemic inflammation is involved in the onset, and its relationship can be predicted, but still controversy about the relationship between them. According to the prior literature, rheumatoid arthritis has reduced the risk of progression to Alzheimer’s disease (AD). Objectives: To investigate the risk of dementia in RA patients based on Korean National Health Insurance Service (NHIS) claim database Methods: We conducted a nationwide population-based study using a Korean NHIS consisted of 1 million individuals, who submitted medical care claims between 2002 and 2013. RA was identified using as the International Classification of Diseases code (ICD-10) M05 (seropositive RA) and dementia was defined as having a prescription of anti-dementia drugs with satisfying the AD (ICD 10 F00 or G30) or vascular dementia (VD, ICD 10 F1.0-1.3, F1.8 and F1.9) codes. The control groups were matched to the RA cohort by age and sex. Results: Of the total 6,028 dementia patients, 100 were diagnosed with RA. In patients with RA over 65 years of age compared to age and sex-matched control group, the dementia risk was shown as whole dementia OR 1.011 (95% CI, 0.811-1.260), AD 1.043 (0.826-1.318), Vascular dementia (VD) 1.274 (0.745-2.177). The sub analysis was performed by dividing the Charlson comorbidities index (CCI) into more than three (moderate) and less than (mild) groups. The mild groups were whole dementia OR 0.851 (0.468-1.546), AD 0.776 (0.392-1.536), VD 0.917 (0.126-6.673), and in the moderate group, whole dementia OR 0.961 (0.750-1.231), AD 0.939 (0.717-0.7) 1.230) and VD 1.219 (0.692-2.149). Conclusion: In conclusion, the risk of dementia in RA patents did not increase when compared to control group. Vascular dementia tended to increase in the RA group, but there was no statistical significance. Disclosure of Interests: None declared
Suboptimal Use of Cardioprotective Medications in Patients With a History of Cancer
Authors: Rossana Untaru, Dongqing Chen, Conagh Kelly, Austin May, Nicholas J. Collins, James Leitch, John R. Attia, Anthony M. Proeitto, Andrew J. Boyle, Aaron L. Sverdlov, Doan T.M. Ngo
Journal: JACC CardioOncology (2020)

Modern cancer therapies have led to improved survival rates for many cancers. Rates of cardiovascular diseases (CVD) and risk factors are increased in cancer patients and survivors compared with the general population, and CVD has emerged as a leading cause of long-term morbidity and mortality in
Acute Blood Pressure-Lowering Effects of Nitrogen Dioxide Exposure From Domestic Gas Cooking Via Elevation of Plasma Nitrite Concentration in Healthy Individuals
Authors: Christopher N. Floyd, Fawzia Shahed, Frances Ukah, Karen McNeill, Kevin O’Gallagher, Charlotte E. Mills, Dimitris Evangelopoulos, Shanon Lim, Ian Mudway, Benjamin Barratt, Heather Walton, Andrew J. Webb
Journal: Circulation Research (2020)
Oseltamivir and influenza-related complications in children: a retrospective cohort in primary care
Authors: Joseph Jonathan Lee, Margaret Smith, Clare Bankhead, Rafael Perera Salazar, Antonis A. Kousoulis, Christopher C. Butler, Kay Wang
Journal: European Respiratory Journal (2020)

Background Influenza and influenza-like illness (ILI) place considerable burden on healthcare systems, especially during influenza epidemics and pandemics. During the 2009/10 H1N1 influenza pandemic, UK national guidelines recommended antiviral medications for patients presenting within 72 h of ILI onset. However, it is not clear whether antiviral treatment was associated with reductions in influenza-related complications. Methods Our study population consisted of a retrospective cohort of children aged ≤17 years who presented with influenza/ILI at UK primary care practices contributing to the Clinical Practice Research Datalink during the 2009/10 pandemic. We used doubly robust inverse-probability weighted propensity scores and physician prior prescribing instrumental variable methods to estimate the causal effect of oseltamivir prescribing on influenza-related complications. Secondary outcomes were complications requiring intervention, pneumonia, pneumonia or hospitalisation, influenza-related hospitalisation and all-cause hospitalisation. Results We included 16 162 children, of whom 4028 (24.9%) were prescribed oseltamivir, and 753 (4.7%) had recorded complications. Under propensity score analyses oseltamivir prescriptions were associated with reduced influenza-related complications (risk difference (RD) −0.015, 95% CI −0.022–−0.008), complications requiring further intervention, pneumonia, pneumonia or hospitalisation and influenza-related hospitalisation, but not all-cause hospitalisation. Adjusted instrumental variable analyses estimated reduced influenza-related complications (RD −0.032, 95% CI −0.051–−0.013), pneumonia or hospitalisation, all-cause and influenza-related hospitalisations. Conclusions Based on causal inference analyses of observational data, oseltamivir treatment in children with influenza/ILI was associated with a small but statistically significant reduction in influenza-related complications during an influenza pandemic.
Ozanimod induction therapy for patients with moderate to severe Crohn's disease: a single-arm, phase 2, prospective observer-blinded endpoint study
Authors: Brian G Feagan, William J Sandborn, Silvio Danese, Douglas C Wolf, Wenzhong J Liu, Steven Y Hua, Neil Minton, Allan Olson, Geert D'Haens
Journal: The Lancet. Gastroenterology & hepatology (2020)
Comparing the Roles of Omalizumab and Ultraviolet Therapy in Treating Severe Pediatric Atopic Dermatitis
Authors: Jewel Park
Journal: JAMA Pediatrics (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Individual and Combined Associations of Modifiable Lifestyle and Metabolic Health Status With New-Onset Diabetes and Major Cardiovascular Events: The China Cardiometabolic Disease and Cancer Cohort (4C) Study
Authors: Mian Li, Yu Xu, Qin Wan, Feixia Shen, Min Xu, Zhiyun Zhao, Jieli Lu, Zhengnan Gao, Gang Chen, Tiange Wang, Yiping Xu, Jiajun Zhao, Lulu Chen, Lixin Shi, Ruying Hu, Zhen Ye, Xulei Tang, Qing Su, Guijun Qin, Guixia Wang, Zuojie Luo, Yingfen Qin, Yanan Huo, Qiang Li, Yinfei Zhang, Yuhong Chen, Chao Liu, Yiming Mu, Youmin Wang, Shengli Wu, Tao Yang, Li Chen, Xuefeng Yu, Li Yan, Huacong Deng, Guang Ning, Yufang Bi, Weiqing Wang
Journal: Diabetes Care (2020)

OBJECTIVE We aimed to determine the individual and combined associations of lifestyle and metabolic factors with new-onset diabetes and major cardiovascular events among a Chinese population aged ≥40 years. RESEARCH DESIGN AND METHODS Baseline lifestyle information, waist circumference, blood pressure, lipid profiles, and glycemic status were obtained in a nationwide, multicenter, prospective study of 170,240 participants. During the up to 5 years of follow-up, we detected 7,847 individuals with new-onset diabetes according to the American Diabetes Association 2010 criteria and 3,520 cardiovascular events, including cardiovascular death, myocardial infarction, stroke, and hospitalized or treated heart failure. RESULTS On the basis of 36.13% (population-attributable fraction [PAF]) risk attributed to metabolic risk components collectively, physical inactivity (8.59%), sedentary behavior (6.35%), and unhealthy diet (4.47%) moderately contributed to incident diabetes. Physical inactivity (13.34%), unhealthy diet (8.70%), and current smoking (3.38%) significantly contributed to the risk of major cardiovascular events, on the basis of 37.42% PAF attributed to a cluster of metabolic risk factors. Significant associations of lifestyle health status with diabetes and cardiovascular events were found across all metabolic health categories. Risks of new-onset diabetes and major cardiovascular events increased simultaneously according to the worsening of lifestyle and metabolic health status. CONCLUSIONS We showed robust effects of lifestyle status on new-onset diabetes and major cardiovascular events regardless of metabolic status and a graded increment of risk according to the combination of lifestyle and metabolic health, highlighting the importance of lifestyle modification regardless of the present metabolic status.
AB0771 DAPSA REMISSION/LOW DISEASE ACTIVITY IS ASSOCIATED WITH LOW PSAID12 IN PSORIATIC ARTHRITIS
Authors: C. García-Porrúa, L. Fernández-Dominguez, J. L. Guerra-Vazquez, J. A. Mosquera Martínez, J. Pinto-Tasende
Journal: Annals of the Rheumatic Diseases (2020)

Background: Psoriatic arthritis (PsA) has a prevalence of 0.17% in North-Western of Spain and patients suffer this disease have significant impact on daily life due to articular, dermatological and psychological symptoms. DAPSA VLDA/LDA (≤14) is a therapeutic goal recommended by EULAR for clinical practice. Objectives: Our aim was to assess the relationship between DAPSA index and PsAID questionnaire in routine clinical practice. Methods: We performed a cross-sectional study of patient and physician reported outcomes. We obtained clinical information of patients with PsA attending clinic from October 2018 to October 2019. Data were collected from clinical records concerning age, gender, disease duration, joint counts, dactylitis, enthesitis, body surface area (BSA) of psoriasis, laboratory results (ESR and CRP), HAQ, PsAID12, pain and global assessment from patient with numerical rating scale (NRS) and DAPSA index. Data were analysed using SPSS21. Logistic regression was used to assess patient reported outcomes which were associated with DAPSA VLDA/LDA. Results: Data were available for 210 patient visits, 43% females. DAPSA≤14 was in 143 patients (68.1%) and was associated with higher disease duration, OR 1.079 (1.020-1.142, 95% CI), p 0.008. DAPSA index was not associated with BSA (r 0.126, p 0.176). PsAID12 was evaluated in 156 patients and we saw that patients with DAPSA≤14 had significantly lower PsAID12 (mean 1.7 ± SD 1.7 vs. 3.9 ± 2.1), p&lt; 0.0001. PsAID12 of less than 4 is considered a good outcome and all items of PsAID12 (Figure 1, mean values for NRS) were less than 4 in patients with DAPSA≤14. All components of PsAID12 except item 3 (skin problems) were associated with DAPSA≤14 on univariate analysis but only pain remained independent predictor on multiple regression analysis (p&lt; 0.0001). Conclusion: In these PsA patients, DAPSA VLDA/LDA was associated with higher disease duration and with lower PsAID12. Pain is dominant symptom in patients with psoriatic arthritis, even in those with DAPSA≤14, and skin problems are not good represented in DAPSA index. References: [1]Gossec L, Ann Rheum Dis. 2014;73(6):1012–1019. [2]Di Carlo, et al: PsAID-12 in clinical setting. J Rheum 2017; 44:3 Acknowledgments: SOGARE Disclosure of Interests: Carlos García-Porrúa: None declared, Luis Fernández-Dominguez: None declared, Jose L. Guerra-Vazquez: None declared, José Antonio Mosquera Martínez: None declared, Jose Pinto-Tasende Consultant of: Janssen, Novartis, Speakers bureau: Lilly, Janssen, Novartis, BMS, Pfizer, Celgene
Construction and application of therapeutic metal-polyphenol capsule for peripheral artery disease
Authors: Jianwei Duan, Zuoguan Chen, Xiaoyu Liang, Youlu Chen, Huiyang Li, Xinxin Tian, Mingming Zhang, Xiaoli Wang, Hongfan Sun, Deling Kong, Yongjun Li, Jing Yang
Journal: Biomaterials (2020)
Recurrent inversion toggling and great ape genome evolution
Authors: David Porubsky, Ashley D. Sanders, Wolfram Höps, PingHsun Hsieh, Arvis Sulovari, Ruiyang Li, Ludovica Mercuri, Melanie Sorensen, Shwetha C. Murali, David Gordon, Stuart Cantsilieris, Alex A. Pollen, Mario Ventura, Francesca Antonacci, Tobias Marschall, Jan O. Korbel, Evan E. Eichler
Journal: Nature Genetics (2020)
Extracorporeal Membrane Oxygenation for Critically Ill Patients with COVID-19–related Acute Respiratory Distress Syndrome: Worth the Effort?
Authors: Pierre-Emmanuel Falcoz, Alexandra Monnier, Marc Puyraveau, Stephanie Perrier, Pierre-Olivier Ludes, Anne Olland, Paul-Michel Mertes, Francis Schneider, Julie Helms, Ferhat Meziani
Journal: American Journal of Respiratory and Critical Care Medicine (2020)
AB0822 WHICH CLINICAL FACTORS INFLUENCE MINERALIZATION OF THE METACARPAL BONES AND FINGER JOINT SPACE WIDTH IN PSORIATIC ARTHRITIS?
Authors: A. Pfeil, M. Heinz, D. Renz, J. Böttcher, G. Wolf, P. Oelzner
Journal: Annals of the Rheumatic Diseases (2020)

Background: Metacarpal bone mineral density as measured by digital x-ray radiogrammetry (DXR-BMD) and finger joint space width quantified by computer-aided joint space analysis presented computer based and observer independent parameters for the evaluation of radiographic damage of the hand skeleton. Objectives: The aim of this study was to quantify clinical parameter which potential influence periarticular mineralisation of the metacarpal bones and finger joint space width in Psoriatic Arthritis (PsA)-patients. Methods: The study includes 201 PsA-patients. All patients received a radiograph of the hand. Bone mineral density was measured by DXR (Pronosco X-Posure System™, Version 2.0; Sectra; Sweden) and finger joint space width of all finger joints were evaluated by computer-aided joint space analysis (CAJSA, Radiogrammetry Kit, Version 1.3.6; Sectra; Sweden). The Z-Score was used as an age- and gender-independent parameter for the quantification finger joint space narrowing. Results: Regarding gender, the DXR-BMD was significant reduced with -0.028 g/cm 2 in women. An equivalent significant result was evaluated for finger joint space width (Z-ScoreMCP -1.07, Z-ScorePIP -0.81 and Z-ScoreDIP -0.76). The DXR-BMD was significantly lowert (-0.011 g/cm 2 ) between the disease duration &lt; 2 years (0.545±0.076 g/cm 2 ) and &gt;10 years (0.509±0.070 g/cm 2 ). The Z-Score showed no significant change regarding the disease duration. Inflammatory activity as measured by c-reactive protein presented no impact on DXR-BMD and the Z-Score of all finger joints. Additionally, the use of corticosteroids was associated with a reduced DXR-BMD (-0.037 g/cm 2 ) and an absence of finger joint space narrowing. Conclusion: The study highlights that the demineralisation of the metacarpal bones was associated with female gender, disease duration and the use of corticosteroids. Whereas, the prior mentioned parameters had no influence on finger joint space width. Consequently, periarticular demineralisation and finger joint space narrowing presented two different and independent radiological signs in PsA. References: N/A Disclosure of Interests: Alexander Pfeil Grant/research support from: This study Investigator Initiated Study “Automatic assessment of joint space narrowing in rheumatoid arthritis based on the Post-hoc analysis” (number: IIS-2016-110818) is a part of the of the Investigator Initiated Study “The quantification of inflammatory related periarticular bone loss in certolizumab pegol treated patients with rheumatoid arthritis” (number: IIS-2014-101458) which is supported by UCB Pharma GmbH, Monheim, Germany., Marcus Heinz: None declared, Diane Renz: None declared, Joachim Böttcher: None declared, Gunter Wolf: None declared, Peter Oelzner: None declared
Covid-19: Students on standby to help with contract tracing
Authors: Cameron A Lynch
Journal: BMJ (2020)

Mahase highlights the government’s reintroduction of contact tracing in the fight against covid-19.1 The government is planning to set up a taskforce of 18 000 contact tracers to combat the spread of the virus.2 This target may be hard to achieve without additional help. Shouldn’t we be seeking out an army of medical students …
ELEVATED RISK FOR LIVER RELATED MORTALITY IN CHRONIC HEPATITIS C PATIENTS BOTH WITH OR WITHOUT ILLICIT SUBSTANCE USE DISORDER : A NATION-WIDE REGISTER STUDY
Authors: Jonas Söderholm, Simon B. Larsson, Anna Jerkeman, Anders Nystedt, Ann-Sofi Duberg, Jan Kövamees, Magdalena Ydreborg, Soo Aleman, Katharina Büsch, Marianne Alanko Blomé, Ola R. Weiland, Martin Kåberg
Journal: Hepatology (2019)

Background: Hepatitis C is a slowly progressive disease mainly transmitted in people who inject drugs . This cohort has a high mortality from drug related causes, such as overdoses or external caus ...
AB0392 THE EFFECT OF HYDROXYCHLOROQUINE ON THE RISK FACTORS FOR ATHEROSCLEROSIS DEVELOPMENT
Authors: R. Wakiya, K. Ueeda, H. Shimada, S. Nakashima, M. Mahmoud Fahmy Mansour, M. Kato, T. Miyagi, K. Sugihara, Y. Ushio, T. Kameda, H. Dobashi
Journal: Annals of the Rheumatic Diseases (2020)

Background: Systemic lupus erythematosus(SLE) patients, especially patients with lupus nephritis have poor vascular endothelial function and increased cardiovascular(CV) mortality. Meanwhile, several studies showed hydroxychloroquine(HCQ) has effect on reduction in lipids and thrombosis(1), but the mechanism is unclear. Objectives: We examined effect of HCQ on adipocytokine expression in SLE patients. Methods: 52 SLE patients with low disease activity started with HCQ were analyzed before and 3 months after HCQ treatment. 21 SLE patients has past history of lupus nephritis. Serum S100 proteins and adipocytokines were measured by ELISA, and serum inflammatory ctytokine levels were evaluated by Multiplex assay (TNF-α, IL-6, VEGF-A). Results: Serum adiponectin level was increased significantly 3 months after HCQ treatment compared with those at baseline (mean change 1.35, Figure 1). SLE patients who achieved LLDAS had a greater increase than those who did not. Additionally, the changes of serum adiponectin levels were associated with those of TNF-α, IL-6, VEGF-A and S100A9 protein, which plays an important role of SLE pathogenesis. Figure 1. Serum adiponectin levels at baseline were compared with levels after 3 months of HCQ treatment. Serum adiponectin levels significantly decreasing during HCQ treatment in SLE patients. For statistical analyses * p &lt;0.0001, P value: Wilcoxon signed-rank test Conclusion: A HCQ could reduce the risk factors for atherosclerosis along with control of SLE disease activity. References: [1]Wallace DJ, et al. Cholesterol-lowering effect of hydroxychloroquine in patients with rheumatic disease: reversal of deleterious effects of steroids on lipids. Am J Med. 1990; 89: 322-6. Disclosure of Interests: None declared
Novel Bispecific Antibody Targeting CD45 and 90Y-DOTA Is Effective Therapy for Acute Myeloid Leukemia in Preclinical Murine Models
Authors: Johnnie J. Orozco, Aimee Kenoyer, Yukang Lin, Darrell R. Fisher, Donald K. Hamlin, D. Scott Wilbur, Alexandra Hernandez, Rosario Guel, Margaret E. Nartea, Shyril O'Steen, Mark D Hylarides, Brian G Till, Damian J. Green, Ajay K. Gopal, Kelly D Orcutt, Karl Dane Wittrup, Brenda M. Sandmaier, John M. Pagel, Oliver W. Press
Journal: Blood (2017)
eNose breath prints as a surrogate biomarker for classifying patients with asthma by atopy
Authors: Mahmoud I. Abdel-Aziz, Paul Brinkman, Susanne J.H. Vijverberg, Anne H. Neerincx, Rianne de Vries, Yennece W.F. Dagelet, John H. Riley, Simone Hashimoto, Paolo Montuschi, Kian Fan Chung, Ratko Djukanovic, Louise J. Fleming, Clare S. Murray, Urs Frey, Andrew Bush, Florian Singer, Gunilla Hedlin, Graham Roberts, Sven-Erik Dahlén, Ian M. Adcock, Stephen J. Fowler, Karen Knipping, Peter J. Sterk, Aletta D. Kraneveld, Anke H. Maitland-van der Zee
Journal: Journal of Allergy and Clinical Immunology (2020)

Electronic noses (eNoses) are emerging point-of-care tools that may help in the subphenotyping of chronic respiratory diseases such as asthma.We aimed to investigate whether eNoses can classify atopy in pediatric and adult patients with asthma.Participants with asthma and/or wheezing from 4 independent cohorts were included; BreathCloud participants (n = 429), Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes adults (n = 96), Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes pediatric participants (n = 100), and Pharmacogenetics of Asthma Medication in Children: Medication with Anti-Inflammatory Effects 2 participants (n = 30). Atopy was defined as a positive skin prick test result (≥3 mm) and/or a positive specific IgE level (≥0.35 kU/L) for common allergens. Exhaled breath profiles were measured by using either an integrated eNose platform or the SpiroNose. Data were divided into 2 training and 2 validation sets according to the technology used. Supervised data analysis involved the use of 3 different machine learning algorithms to classify patients with atopic versus nonatopic asthma with reporting of areas under the receiver operating characteristic curves as a measure of model performance. In addition, an unsupervised approach was performed by using a bayesian network to reveal data-driven relationships between eNose volatile organic compound profiles and asthma characteristics.Breath profiles of 655 participants (n = 601 adults and school-aged children with asthma and 54 preschool children with wheezing [68.2% of whom were atopic]) were included in this study. Machine learning models utilizing volatile organic compound profiles discriminated between atopic and nonatopic participants with areas under the receiver operating characteristic curves of at least 0.84 and 0.72 in the training and validation sets, respectively. The unsupervised approach revealed that breath profiles classifying atopy are not confounded by other patient characteristics.eNoses accurately detect atopy in individuals with asthma and wheezing in cohorts with different age groups and could be used in asthma phenotyping.