tbuckley/cabot-search huggingface dataset:
Hemorrhage from the point of traction on the opposing wall after colonic endoscopic submucosal dissection using countertraction: a rare adverse event
Authors: Adrien Patenotte, Alexandru Lupu, Jérémie Jacques, Jérôme Rivory, Florian Rostain, Mathieu Pioche
Journal: Endoscopy (2020)

Endoscopic submucosal dissection (ESD) is recommended for complete en bloc resection of colonic lesions that are larger than 20 mm and with a high risk of limited submucosal invasion, based on depressed morphology and an irregular or nongranular surface pattern [1]. Recent studies have shown that countertraction techniques using clips and a rubber band increase the R0 resection rate and significantly decrease the procedure time, while also decreasing the complication rates (perforation and bleeding) [2].
Abstract 14421: Addressing ST Elevation Myocardial Infarction (STEMI) False Positives in Racial Subpopulations Due to Current ECG Criteria
Authors: Muhammad Soofi, Victor F Froelicher
Journal: Circulation (2019)

Introduction: The Universal Definition of Myocardial Infarction (UDMI) defines ECG criteria for diagnosing ST elevation MI (STEMI) and adjusts for age and gender but not race. The UDMI criteria are...
A Novel Biomarker-Based Model for the Prediction of Response to Sorafenib and Overall Survival for Advanced Hepatocellular Carcinoma: A Prospective Cohort Study
Authors: Hwi Young Kim, Dong Hyeon Lee, Eun Ju Cho, Su Jong Yu, Yoon Jun Kim, Jung-Hwan Yoon, Jeong-Hoon Lee
Journal: Hepatology (2018)
E-pipe use leading to lipoid pneumonia in Europe
Authors: Anne-Catherine Kessler, Corina Dommann, Yvonne Nussbaumer-Ochsner
Journal: Thorax (2020)

A 53-year-old, so far healthy woman was admitted to the emergency department due to increasing cough and dyspnoea. Four days before presentation, the general practitioner initiated an outpatient treatment with amoxicilin/clavulanic acid due to the clinical and radiological suspicion of a bilateral, community-acquired pneumonia. Apart from escitalopram and oestrogen containing hormone replacement therapy, she did not use any medication. She had no pets or humidifier and worked as a saleswoman in a gift shop.

Three weeks before admission, she switched from conventional cigarettes to commercial available electronic pipe (nicotine content 4 mg/mL, taste of pipe tobacco and refillable tank). She performed inhalations approximately 4–5 times per day. She denied using cannabinoid-containing liquids and was no dual user. Ten days after starting consuming the electronic pipe, the patient suffered from dry cough and dyspnoea when hurrying upstairs.

On admission, the …
Reply to Cherian <i>et al.</i>: Positive Bubble Study in Severe COVID-19 Indicates the Development of Anatomical Intrapulmonary Shunts in Response to Microvascular Occlusion
Authors: Alexandra S. Reynolds, Alison G. Lee, Joshua Renz, Katherine DeSantis, John Liang, Charles A. Powell, Corey E. Ventetuolo, Hooman D. Poor
Journal: American Journal of Respiratory and Critical Care Medicine (2020)
β-Galactosylceramidase Promotes Melanoma Growth via Modulation of Ceramide Metabolism
Authors: Mirella Belleri, Giuseppe Paganini, Daniela Coltrini, Roberto Ronca, Daniela Zizioli, Michela Corsini, Andrea Barbieri, Elisabetta Grillo, Stefano Calza, Roberto Bresciani, Eugenio Maiorano, Mauro G. Mastropasqua, Tiziana Annese, Arianna Giacomini, Domenico Ribatti, Josefina Casas, Thierry Levade, Gemma Fabrias, Marco Presta
Journal: Cancer Research (2020)

Disturbance of sphingolipid metabolism may represent a novel therapeutic target in metastatic melanoma, the most lethal form of skin cancer. β-Galactosylceramidase (GALC) removes β-galactose from galactosylceramide and other sphingolipids. In this study, we show that downregulation of galcb, a zebrafish ortholog of human GALC, affects melanoblast and melanocyte differentiation in zebrafish embryos, suggesting a possible role for GALC in melanoma. On this basis, the impact of GALC expression in murine B16-F10 and human A2058 melanoma cells was investigated following its silencing or upregulation. Galc knockdown hampered growth, motility, and invasive capacity of B16-F10 cells and their tumorigenic and metastatic activity when grafted in syngeneic mice or zebrafish embryos. Galc-silenced cells displayed altered sphingolipid metabolism and increased intracellular levels of ceramide, paralleled by a nonredundant upregulation of Smpd3, which encodes for the ceramide-generating enzyme neutral sphingomyelinase 2. Accordingly, GALC downregulation caused SMPD3 upregulation, increased ceramide levels, and inhibited the tumorigenic activity of human melanoma A2058 cells, whereas GALC upregulation exerted opposite effects. In concordance with information from melanoma database mining, RNAscope analysis demonstrated a progressive increase of GALC expression from common nevi to stage IV human melanoma samples that was paralleled by increases in microphthalmia transcription factor and tyrosinase immunoreactivity inversely related to SMPD3 and ceramide levels. Overall, these findings indicate that GALC may play an oncogenic role in melanoma by modulating the levels of intracellular ceramide, thus providing novel opportunities for melanoma therapy. SIGNIFICANCE: Data from zebrafish embryos, murine and human cell melanoma lines, and patient-derived tumor specimens indicate that β-galactosylceramidase plays an oncogenic role in melanoma and may serve as a therapeutic target.
Early Detection of Human Papillomavirus–Driven Oropharyngeal Cancer Using Serology From the Study of Prevention of Anal Cancer
Authors: Tim Waterboer, Nicole Brenner, Richard Gallagher, Richard John Hillman, Fengyi Jin, Andrew Grulich, Isobel Mary Poynten
Journal: JAMA Oncology (2020)

This case series examines HPV seropositivity and antibody levels in a cohort of older men who have sex with men.
Incorporating Optical Coherence Tomography Macula Scans Enhances Cost-effectiveness of Fundus Photography-Based Screening for Diabetic Macular Edema
Authors: Ian Y.H. Wong, Raymond L.M. Wong, Jonathan C.H. Chan, Ryo Kawasaki, Victor Chong
Journal: Diabetes Care (2020)

OBJECTIVE To compare four screening strategies for diabetic macular edema (DME). RESEARCH DESIGN AND METHODS Patients attending diabetic retinopathy screening were recruited and received macular optical coherence tomography (OCT), in addition to visual acuity (VA) and fundus photography (FP) assessments, as part of the standard protocol. Two retina specialists provided the reference grading by independently assessing each subject’s screened data for DME. The current standard protocol (strategy A) was compared for sensitivity, specificity, quality-adjusted life-year (QALY) gained, and incremental cost-effectiveness ratio (ICER) with three alternative candidate protocols using a simulation model with the same subjects. In strategy B, macular hemorrhage or microaneurysm on FP were removed as surrogate markers for possible DME. Strategy C used best-corrected instead of habitual/pinhole VA and added central subfield thickness (CST) &amp;gt;290 μm on OCT in suspected cases as a confirmation marker for possible DME. Strategy D used CST &amp;gt;290 μm OCT in all subjects as a surrogate marker for suspected DME. RESULTS We recruited 2,277 subjects (mean age 62.80 ± 11.75 years, 43.7% male). The sensitivities and specificities were 40.95% and 86.60%, 22.86% and 95.63%, 32.38% and 100%, and 74.47% and 98.34% for strategies A, B, C, and D, respectively. The costs (in U.S. dollars) of each QALY gained for strategies A, B, C, and D were $7,447.50, $8,428.70, $5,992.30, and $4,113.50, respectively. CONCLUSIONS The high false-positive rate of the current protocol generates unnecessary referrals, which are inconvenient for patients and costly for society. Incorporating universal OCT for screening DME can reduce false-positive results by eightfold, while improving sensitivity and long-term cost-effectiveness.
5-Hydroxymethylcytosine of Circulating Cell-Free DNA in Plasma: A Novel Non-Invasive Marker for Progression and Prognosis in Multiple Myeloma
Authors: Brian C.-H. Chiu, Qiancheng You, Zhou Zhang, Elizabeth Stepniak, Xu Zhang, Meytal Chernoff, Todd M. Zimmerman, Chuan He, Wei Zhang
Journal: Blood (2017)
Biomechanical Footwear for Osteoarthritic Knee Pain—Reply
Authors: Stephan Reichenbach, David T. Felson, Peter Jüni
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Survival and Motor Phenotypes in FVB C9-500 ALS/FTD BAC Transgenic Mice Reproduced by Multiple Labs
Authors: Lien Nguyen, Lauren A. Laboissonniere, Shu Guo, Federica Pilotto, Olivier Scheidegger, Angelina Oestmann, Jennetta W. Hammond, Herman Li, Anu Hyysalo, Roosa Peltola, Amrutha Pattamatta, Tao Zu, Merja H. Voutilainen, Harris A. Gelbard, Smita Saxena, Laura P.W. Ranum
Journal: Neuron (2020)
Azole resistance survey on clinical Aspergillus fumigatus isolates in Spain
Authors: Pilar Escribano, Belén Rodríguez-Sánchez, Judith Díaz-García, María Teresa Martín-Gómez, Elisa Ibáñez-Martínez, María Rodríguez-Mayo, Teresa Peláez, Elia García-Gómez de la Pedrosa, Rocío Tejero-García, José María Marimón, Elena Reigadas, Antonio Rezusta, Cristina Labayru-Echeverría, Ana Pérez-Ayala, Josefina Ayats, Fernando Cobo, Carmen Pazos, Leyre López-Soria, Ana Alastruey-Izquierdo, Patricia Muñoz, Jesús Guinea, Waldo Sánchez-Yebra, Juan Sánchez-Gómez, Inmaculada Lozano, Eduardo Marfil, Montserrat Muñoz de la Rosa, Rocío Tejero García, Fernando Cobo, Carmen Castro, Concepción López, Antonio Rezusta, Teresa Peláez, Cristian Castelló-Abietar, Isabel Costales, Julia Lozano Serra, Rosa Jiménez, Cristina Labayru Echeverría, Cristina Losa Pérez, Gregoria Megías-Lobón, Belén Lorenzo, Ferrán Sánchez-Reus, Josefina Ayats, María Teresa Martín, Inmaculada Vidal, Victoria Sánchez-Hellín, Elisa Ibáñez, Javier Pemán, Miguel Fajardo, Carmen Pazos, María Rodríguez-Mayo, Ana Pérez-Ayala, Elia Gómez, Jesús Guinea, Pilar Escribano, Julia Serrano, Elena Reigadas, Belén Rodríguez, Estreya Zvezdanova, Judith Díaz-García, Ana Gómez-Núñez, José González Leiva, Marina Machado, Patricia Muñoz, Isabel Sánchez-Romero, Julio García-Rodríguez, José Luis del Pozo, Manuel Rubio Vallejo, Carlos Ruiz de Alegría-Puig, Leyre López-Soria, José María Marimón, Diego Vicente, Marina Fernández-Torres, Silvia Hernáez-Crespo
Journal: Clinical Microbiology and Infection (2020)

We aimed to assess the percentage of azole resistance in Aspergillus fumigatus in Spain.Thirty participating Spanish hospitals stored all morphologically identified A. fumigatus sensu lato clinical isolates-regardless their clinical significance-from 15 February to 14 May 2019. Isolates showing azole resistance according to the EUCAST 9.3.2 methodology were molecularly identified and the cyp51A gene was studied in A. fumigatus sensu stricto isolates.Eight hundred and forty-seven isolates from 725 patients were collected in 29 hospitals (A. fumigatus sensu stricto (n = 828) and cryptic species (n = 19)). Isolates were mostly from the lower respiratory tract (94.0%; 797/847). Only cryptic species were amphotericin B resistant. Sixty-three (7.4%) out of the 847 isolates were resistant to ≥1 azole(s). Azole resistance was higher in cryptic species than in A. fumigatus sensu stricto (95%, 18/19 vs. 5.5%, 45/828); isavuconazole was associated to the lowest number of non-wild type isolates. The dominant mechanism of resistance was the presence of TR34-L98H substitutions (n = 24 out of 63). Out of the 725 patients, 48 (6.6%) carried either cryptic species (n = 14) or A. fumigatus sensu stricto (n = 34; 4.7%) resistant isolates. Aspergillus fumigatus sensu stricto harbouring either the TR34-L98H (n = 19) or TR46/Y121F/T289A (n = 1) mutations were detected in patients in hospitals located at 7/24 studied cities.Of the patients, 6.6% carry azole-resistant A. fumigatus sensu lato isolates in Spain. TR34-L98H is the dominant cyp51A gene substitutions, although its presence is not widespread.
In-depth analysis of a mixed Mycobacterium tuberculosis infection involving a multidrug-resistant strain and a susceptible strain
Authors: Estefanía Abascal, Marta Herranz, María Jesús Ruiz Serrano, Francisco Fernández-González, Patricia Muñoz, Eduardo Gotuzzo, Darío García de Viedma
Journal: Clinical Microbiology and Infection (2020)
Abstract 18360: Melatonin Protects Cardiac Microvasculature Against Ischemia/reperfusion Injury via Suppression of Mitochondrial Fission/VDAC1/HK2/mPTP/Mitophagy Axis by Activation of AMPKα
Authors: Hao Zhou, Nan Hu, Feng Cao, yundai chen, Jun Ren
Journal: Circulation (2017)

Introduction: The cardiac microvascular ischemia/reperfusion injury (IRI) is a neglected topic with limited therapeutic strategies available. Hypothesis: Melatonin protects cardiac microvasculature...
A6 peptide-tagged, ultra-small and reduction-sensitive polymersomal vincristine sulfate as a smart and specific treatment for CD44+ acute myeloid leukemia
Authors: Wenxing Gu, Tianhui Liu, Daoyang Fan, Jubin Zhang, Yifeng Xia, Fenghua Meng, Yang Xu, Jeroen J.L.M. Cornelissen, Zhongjun Liu, Zhiyuan Zhong
Journal: Journal of Controlled Release (2020)
A systematic comparison of chloroplast genome assembly tools
Authors: Jan A. Freudenthal, Simon Pfaff, Niklas Terhoeven, Arthur Korte, Markus J. Ankenbrand, Frank Förster
Journal: Genome biology (2020)

Abstract Background Chloroplasts are intracellular organelles that enable plants to conduct photosynthesis. They arose through the symbiotic integration of a prokaryotic cell into an eukaryotic host cell and still contain their own genomes with distinct genomic information. Plastid genomes accommodate essential genes and are regularly utilized in biotechnology or phylogenetics. Different assemblers that are able to assess the plastid genome have been developed. These assemblers often use data of whole genome sequencing experiments, which usually contain reads from the complete chloroplast genome. Results The performance of different assembly tools has never been systematically compared. Here, we present a benchmark of seven chloroplast assembly tools, capable of succeeding in more than 60% of known real data sets. Our results show significant differences between the tested assemblers in terms of generating whole chloroplast genome sequences and computational requirements. The examination of 105 data sets from species with unknown plastid genomes leads to the assembly of 20 novel chloroplast genomes. Conclusions We create docker images for each tested tool that are freely available for the scientific community and ensure reproducibility of the analyses. These containers allow the analysis and screening of data sets for chloroplast genomes using standard computational infrastructure. Thus, large scale screening for chloroplasts within genomic sequencing data is feasible.
The multi-faces of Angptl8 in health and disease: Novel functions beyond lipoprotein lipase modulation
Authors: Mohamed Abu-Farha, Anindya Ghosh, Irina Al-Khairi, S.R. Murthy Madiraju, Jehad Abubaker, Marc Prentki
Journal: Progress in Lipid Research (2020)

Angiopoietin-like protein (ANGPTL) family members, mainly ANGPTL3, ANGPTL4 and ANGPTL8, are physiological inhibitors of lipoprotein lipase (LPL), and play a critical role in lipoprotein and triglyceride metabolism in response to nutritional cues. ANGPTL8 has been described by different names in various studies and has been ascribed various functions at the systemic and cellular levels. Circulating ANGPTL8 originates mainly from the liver and to a smaller extent from adipose tissues. In the blood, ANGPTL8 forms a complex with ANGPTL3 or ANGPTL4 to inhibit LPL in fed or fasted conditions, respectively. Evidence is emerging for additional intracellular and receptor-mediated functions of ANGPTL8, with implications in NFκB mediated inflammation, autophagy, adipogenesis, intra-cellular lipolysis and regulation of circadian clock. Elevated levels of plasma ANGPTL8 are associated with metabolic syndrome, type 2 diabetes, atherosclerosis, hypertension and NAFLD/NASH, even though the precise relationship is not known. Whether ANGPTL8 has direct pathogenic role in these diseases, remains to be explored. In this review, we develop a balanced view on the proposed association of this protein in the regulation of several pathophysiological processes. We also discuss the well-established functions of ANGPTL8 in lipoprotein metabolism in conjunction with the emerging novel extracellular and intracellular roles of ANGPTL8 and the implicated metabolic and signalling pathways. Understanding the diverse functions of ANGPTL8 in various tissues and metabolic states should unveil new opportunities of therapeutic intervention for cardiometabolic disorders.
<i>Lactobacillus paracasei</i> KBL382 administration attenuates atopic dermatitis by modulating immune response and gut microbiota
Authors: Woon-Ki Kim, You Jin Jang, Dae Hee Han, Kyungchan Jeon, Cheonghoon Lee, Hyuk Seung Han, GwangPyo Ko
Journal: Gut Microbes (2020)

Administration of probiotics has been linked to immune regulation and changes in gut microbiota composition, with effects on atopic dermatitis (AD). In this study, we investigated amelioration of the symptoms of AD using
Prehospital Tranexamic Acid
Authors: Ryan P. Dumas, Matthew J. Martin
Journal: JAMA Surgery (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Abstract B16: The immune profile of sentinel lymph nodes in melanoma
Authors: Georgia M. Beasley, Eda K. Holl, Norma E. Farrow, Margaret G. Leddy, April K. Salama, Brent A. Hanks, Smita K. Nair
Journal: Cancer Research (2020)

Abstract Background: Immune cell composition and immune-mediated processes occurring in the sentinel lymph node (SLN) of melanoma patients regulate generation of tumor-specific effector T-cell responses and ultimately tumor control. We hypothesized that comprehensive analysis of these immune-associated processes in the SLN biopsy may identify patients at high risk of melanoma recurrence. Methods: We analyzed 38 formalin-fixed, paraffin-embedded sentinel lymph nodes from melanoma patients undergoing SLN biopsy from 2009-2012 using the NanoString nCounter® PanCancer Immune Profiling panel. The panel included 770 immune related genes. Results: Of 38 patients, 19 were SLN negative and 19 were SLN positive. Among SLN-negative patients (n=19), the median Breslow depth was 1.25 mm, and 21% (n=4) had developed recurrence at median follow-up of 6.2 years. Among SLN-positive patients, the median Breslow depth was 3.35 mm and 37% (n=7) had developed recurrence at median follow-up of 6.5 years. There were 31 genes significantly differentially expressed (P&amp;lt;0.01) in SLN positive compared to SLN negative, including higher relative expression of B-cell signaling markers (CD19, CD22, Pax5, CXCR5, CD79B). Among all 38 patients, there were 13 genes differentially expressed (P&amp;lt;0.05) between patients with and without recurrence, including higher relative expression of IL6 in patients with recurrence compared to no recurrence. Further analysis is ongoing. Conclusion: In this retrospective series, we found the immunologic gene expression profile of melanoma SLNs was significantly different in SLN negative versus SLN positive. There were also significant differences in the profile between patients who developed melanoma recurrence versus no recurrence regardless of SLN status. We aim to build on these pilot data. The goal is to use this profile to predict patients at high risk of recurrence after SLNB who may benefit from adjuvant therapy. Citation Format: Georgia M. Beasley, Eda K. Holl, Norma E. Farrow, Margaret G. Leddy, April K. Salama, Brent A. Hanks, Smita K. Nair. The immune profile of sentinel lymph nodes in melanoma [abstract]. In: Proceedings of the AACR Special Conference on Melanoma: From Biology to Target; 2019 Jan 15-18; Houston, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(19 Suppl):Abstract nr B16.