FRI0348 Mbl2 gene polymorphisms and its association with infection in brazilian systemic lupus erythematosus patients: a 10-year study
Authors: C.F. Saldanha, G.K. da Silva, N. Glesse, J.C.T. Brenol, J.A.B. Chies, O.A. Monticielo
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Systemic lupus erythematosus (SLE) is a multifactorial disease and <i>MBL2</i> genetics variants potentially affect its etiology and increase infection risk in this population. Systemic lupus erythematosus (SLE) is a multifactorial disease and <i>MBL2</i> genetics variants potentially affect its etiology and increase infection risk in this population. <h3>Objectives</h3> To evaluate the relation of <i>MBL2</i> gene polymorphisms of the coding and promoter region and their respective haplotypes on hospitalisation, number of admissions and days of admission for major infection causes in Brazilian SLE patients. <h3>Methods</h3> Three hundred and twenty-five SLE patients from a southern Brazilian outpatient SLE clinic were genotyped in 2006 for <i>MBL2</i> gene polymorphisms from coding and promoter region (rs1800450, rs1800451, rs5030737, rs11003125, and rs7096206) and followed until 2016. Clinical and laboratory data from each patient was obtained and information regarding the need for hospitalisation, the number of admissions and amount of days admitted for infection treatment were compiled and compared with <i>MBL2</i> gene polymorphisms and haplotypes. A linear regression analysis was constructed considering the variables of bivariate which demonstrated an association (p&lt;0.05) and variables which had a theoretical basement. <h3>Results</h3> No difference was found in polymorphism prevalence when comparing the group that was admitted for infection treatment and the group who did not. Allele C, and haplotypes LY and HY correlated with more infection hospitalizations (normal homozygosis for C: 2 (IQR 1–3), heterozygosis for C: 3 (IQR 2–6) p=0.038; LY 2 (IQR 1–3) p=0.049; HY 2 (IQR 1–3) p=0.005) and haplotype HY staid fewer days in hospital for infection treatment: 18 (IQR 10–38) p=0.041. The table 1 shows the results after regression model was applied. <h3>Conclusions</h3> The presence of the HY promoter haplotype leads to fewer in hospital care for infection treatment probably due to higher MBL plasma levels. Also, HY haplotype and older age at SLE diagnosis is related to less admissions for infection. It is important to consider that infection is a very import cause of mortality in SLE patients and not only related to aggressive immunosuppressive treatment. <h3>References</h3> [1] Garred P, Voss A, Madsen HO, Junker P. Association of mannose-binding lectin gene variation with disease severity and infections in a population-based cohort of systemic lupus erythematosus patients. Genes Immun. 2001;2(8):442–450. [2] Kinder BW, Freemer MM, King Jr TE, et al. Clinical and Genetic Risk Factors for Pneumonia in Systemic Lupus Erythematosus. Arthritis Rheum. 2007;56(8):2679–2686. [3] Mok MY, Eddie IP W, Lau CS, Lo Y, Wong WHS, Lau YL. Mannose-Binding Lectin and Susceptibility to Infection in Chinese Patients with Systemic Lupus Erytematosus. J Rheumatol. 2007;34(6):1270–1276. <h3>Disclosure of Interest</h3> None declared