Excess Burden of Mental Illness and Hospitalization in Young-Onset Type 2 Diabetes
Authors: Calvin Ke, Baiju R. Shah, Thérèse A. Stukel, Juliana C.N. Chan, Andrea Luk
Journal: Annals of Internal Medicine (2019)

Letters2 July 2019Excess Burden of Mental Illness and Hospitalization in Young-Onset Type 2 DiabetesCalvin Ke, MD, Baiju R. Shah, MD, PhD, Thérèse A. Stukel, PhD, Juliana C.N. Chan, MBChB, MD, and Andrea Luk, MBChB, MDCalvin Ke, MDUniversity of Toronto, Toronto, Ontario, Canada (C.K.)Search for more papers by this author, Baiju R. Shah, MD, PhDUniversity of Toronto, Institute for Clinical Evaluative Sciences, and Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada (B.R.S.)Search for more papers by this author, Thérèse A. Stukel, PhDUniversity of Toronto and Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada (T.A.S.)Search for more papers by this author, Juliana C.N. Chan, MBChB, MDThe Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong (J.C.C., A.L.)Search for more papers by this author, and Andrea Luk, MBChB, MDThe Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong (J.C.C., A.L.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L19-0243 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree with Dr. Finucane that death and major adverse cardiovascular events are associated with T2D but do not propose that all persons with this condition may benefit from intensive treatment of high blood glucose levels or other modifiable risk factors. As Dr. Finucane notes, previous randomized trials have shown that intensive treatment reduces death rates slightly if at all (1–3). However, these studies involved populations with usual-onset T2D of advanced duration (mean age, 62.2 years [SD, 6.8]; 66 years [SD, 6]; and 60.5 years [SD, 9.0], respectively, and mean disease duration, 10 years; 7.9 years [SD, 6.3]; ...References1. Gerstein HC, Miller ME, Byington RP, et al; Action to Control Cardiovascular Risk in Diabetes Study Group.. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med. 2008;358:2545-59. [PMID: 18539917] doi:10.1056/NEJMoa0802743 CrossrefMedlineGoogle Scholar2. Patel A, MacMahon S, Chalmers J, et al; ADVANCE Collaborative Group.. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med. 2008;358:2560-72. [PMID: 18539916] doi:10.1056/NEJMoa0802987 CrossrefMedlineGoogle Scholar3. Duckworth W, Abraira C, Moritz T, et al; VADT Investigators.. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med. 2009;360:129-39. [PMID: 19092145] doi:10.1056/NEJMoa0808431 CrossrefMedlineGoogle Scholar4. Miller ME, Bonds DE, Gerstein HC, et al; ACCORD Investigators.. The effects of baseline characteristics, glycaemia treatment approach, and glycated haemoglobin concentration on the risk of severe hypoglycaemia: post hoc epidemiological analysis of the ACCORD study. BMJ. 2010;340:b5444. [PMID: 20061360] doi:10.1136/bmj.b5444 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Toronto, Toronto, Ontario, Canada (C.K.)University of Toronto, Institute for Clinical Evaluative Sciences, and Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada (B.R.S.)University of Toronto and Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada (T.A.S.)The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong (J.C.C., A.L.)Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M18-1900. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoExcess Burden of Mental Illness and Hospitalization in Young-Onset Type 2 Diabetes Calvin Ke , Eric Lau , Baiju R. Shah , Thérèse A. Stukel , Ronald C. Ma , Wing-Yee So , Alice P. Kong , Elaine Chow , Philip Clarke , William Goggins , Juliana C.N. Chan , and Andrea Luk Excess Burden of Mental Illness and Hospitalization in Young-Onset Type 2 Diabetes Thomas E. Finucane Metrics Cited byPathophysiology, phenotypes and management of type 2 diabetes mellitus in Indian and Chinese populationsTemporal Trend in Young-Onset Type 2 Diabetes—Macrovascular and Mortality Risk: Study of U.K. Primary Care Electronic Medical Records 2 July 2019Volume 171, Issue 1Page: 78-79KeywordsBloodForecastingGlucoseHospitalizationsHypoglycemiaHypoglycemicsMedical risk factorsPopulation statisticsRandomized trialsType 2 diabetes ePublished: 2 July 2019 Issue Published: 2 July 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...