tbuckley/cabot-search huggingface dataset:
AB0254 NEUTROPHIL-LYMPHOCYTE RATIO AND PLATELET-LYMPHOCYTE RATIO IN PATIENTSRECEIVING ANTIRHEUMATIC THERAPY: RELATIONSHIP TO CLINICAL AND LABORATORY MARKERS OF DISEASE ACTIVITY
Authors: Iris Paola Guzmán-Guzmán, Oscar Zaragoza-García, José Eduardo Navarro-Zarza, Isela Parra-Rojas
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> The use of antirheumatic drugs is key to limit or prevent inflammation and joint damage in rheumatoid arthritis (RA). Recently, neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) has been considered markers of clinical activity in RA<sup>1</sup>, however its relationship with serological and clinical parameters in patients receiving disease modifying drugs (DMARDs) therapy has been poorly evaluated. <h3>Objectives</h3> To analyze the association of NLR and PLR with serological and clinical parameters related to the clinical prognosis in RA patients with antirheumatic treatment. <h3>Methods</h3> A cross-sectional study was carried out in 150 women with RA (mean age of 45.5 years, and mean duration of disease of 8 years) all diagnosed according to ACR/EULAR 2010 criteria and receiving DMARDs and corticosteroids (Cs) therapy. The clinical features and DAS-28 score were analyzed by a rheumatologist professional. The NLR and PLR, as well as the e<i>rythrocyte sedimentation rate</i> (ESR), high sensitivity C reactive protein (hsCRP) levels, rheumatoid factor (RF) and anti-cyclic citrullinated peptides (anti-CCPs) antibodies, were determined in the laboratory. <h3>Results</h3> The medical schemes prescribed commonly were: Methotrexate (MTX) monotherapy and MTX combination with chloroquine, sulfasalazine, leflunomide and Cs. The NLR was correlated with DAS28-ESR and DAS28-hsCRP scores. The values of NLR &gt;2.2 (percent neutrophil/percent lymphocyte) were associated with hsCRP &gt;12 mg/L (OR=2.45, p=0.036), DAS28-hsCRP &gt;5.1 (OR=2.69, p=0.07) and with anti-CCPs-positive (&gt;5 U/mL) (OR=1.57, p=0.41). While, PLR &gt;10.4 (platelet count×10<sup>3</sup>/mm<sup>3</sup>/percent lymphocyte) was too associated (OR=3.72, p=0.004; OR=2.51, p=0.08; OR=2.96, p=0.07, respectively). Serological autoantibodies, when was considered in combination, the anti-CCPs/RF-positive patients showed a higher correlation between NLR and PLR with the parameters of clinical activity [tender joints count (r=0.19, p=0.036; r=0.16, p=0.07), swollen joints count (r=0.15, p=0.08; r=0.14, p=0.11) and DAS28-hsCRP score (r=0.16, p=0.06; r=0.17, p=0.05)], however this correlation was higher in anti-CCPs-positive but RF-negative patients. In addition, was observed that patients with DMARDs combination and a greater number of drugs had increased NLR and PLR. <h3>Conclusion</h3> NLR and PLR could be considered markers for the evaluation of the clinical course and response to therapy DMARDs in RA patients. <h3>Reference</h3> [1] Sargin G, Senturk T, Yavasoglu I, et al. Relationship between neutrophil-lymphocyte, platelet-lymphocyte ratio and disease activity in rheumatoid arthritis treated with rituximab. Int J Rheum Dis. 2018. doi.org/10.1111/1756-185X.13400 <h3>Disclosure of Interests</h3> None declared
Serum creatinine, urea nitrogen and hematocrite in the early detection of pancreatic necrosis
Authors: Goran Poropat, Goran Hauser, Vanja Licul, Davor Štimac
Journal: Gut (2009)

INTRODUCTION: Pancreatic necrosis is a serious local complication of acute pancreatitis associated with worse clinical outcome and higher mortality. AIMS & METHODS: The main focus of our study was to identify predictive value of serum creatinine, urea nitrogen and hematocrit in early detection of pancreatic necrosis in patients with acute pancreatitis.We analyzed 97 patients with moderate to severe acute pancreatitis defined by an APACHE II score of 6 and more. All subjects performed computerized tomography (CT) between days 4 and 7 of admission with the calculation of CTSI score. Values of serum creatinine, urea nitrogen and hematocrit were assessed on admission and on days 2 and 3. We calculated the intravenous fluid resuscitation volume for each patient on admission and within 72 h of admission. RESULTS: Of 97 included patients, 24 (25%) developed pancreatic necrosis. Low serum hematocrit on admission showed a negative predictive value of 82%, while no significant results were obtained for serum creatinine and urea nitrogen. ROC curves for pancreatic necrosis revealed an area under the curve of 0.67 for admission hematocrit, 0.44 for peak creatinine, and 0.48 for peak urea nitrogen. Binary logistic regression retrieved no significant association between the three tests and pancreatic necrosis. We found that patients who developed pancreatic necrosis received a significantly higher volume of intravenous fluid resuscitation within the first 24 h (P<0.005). CONCLUSION: We confirmed that a low admission hematocrit is associated with a low incidence of pancreatic necrosis. Our results don't suggest significant association of serum creatinine and urea nitrogen values with the development of pancreatic necrosis.
AB0824 THE EFFECTS OF CEMENT VOLUME DISTRIBUTION OF PERCUTANEOUS KYPHOPLASTY IN OSTEOPOROTIC VERTEBRAL FRACTURE
Authors: Keng Chen, Ram Chaudhary, Zhaopeng Cai, Lin Huang, Zhongyu Xie, Peng Wang, Huiyong Shen
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> Osteoporotic vertebral compression fractures (OVCF) account for 45% of osteoporotic fractures. It cause severe back pain, unable walk or even stand Percutaneous kyphoplasty (PKP) is commonly used to treat painful OVCF, effective relieve pain and walking ability. But there have been few clinical studies that have specifically explored the relationship of the cement volume distribution rate and clinical outcomes. <h3>Objectives</h3> To access the effect of the cement volume distribution pattern in percutaneous kyphoplasty. <h3>Methods</h3> We retrospectively reviewed 126 cases of osteoporotic compression fractures treated with percutaneous kyphoplasty from Jan 2005 to May 2015. The cement volume distribution (CVD) was measured with X-ray and CT scan. 126 thoracolumbar vertebrae were divided into two groups based on CVD ratio: 51 vertebrae in group A with CVD ratio&lt;=2; 15 in group B with CVD ratio&gt;2. The relationships of the cement volume distribution and clinical outcomes of pain, vertebral height and kyphotic angle change between the two groups were compared <h3>Results</h3> The mean duration of follow-up was 25 months (range 11∼76), and the mean age was 68.2±8.7 years. Correlation of volume of cement distribution measured by CT scan and X-ray is 89.3% (P&lt;0.001). The VAS improvement after kyphoplasty was no statistically significant (P = 0.651). Statistically greater height gain was observed in group B at the anterior border (4.42±2.42 VS 1.83±1.5, P = 0.035) and at the center (4.64±1.73 VS 3.01±0.41, P = 0.044). Subsequent fracture was 7 cases in group A and 4 case in group B. <h3>Conclusion</h3> Larger volume of cement distribution, greater correction of kyphosis. The greater distribution of the cement without leakage would be suggested when the limited volume of cement is injected. <h3>References</h3> [1] Rebolledo B J, Gladnick B P, Unnanuntana A, et al. Comparison of unipedicular and bipedicular balloon kyphoplasty for the treatment of osteoporotic vertebral compression fractures A prospective randomised study[J]. Bone Joint J, 2013, 11(3):401-406. [2] Lian-Hua L I, Tian-Sheng S, Zhi L, et al. Comparison of unipedicular and bipedicular percutaneous kyphoplasty for treating osteoporotic vertebral compression fractures: a meta-analysis[J]. Chin Med J (Eng), 2013, 126(20). [3] Song B K, Eun J P, Oh Y M. Clinical and radiological comparison of unipedicular versus bipedicular balloon kyphoplasty for the treatment of vertebral compression fractures[J]. Osteoporosis International, 2009, 20(10):1717-1723. <h3>Acknowledgement</h3> National Natural Science Foundation (81703163) <h3>Disclosure of Interests</h3> None declared
Suppression of YAP/TAZ-Notch1-NICD axis by bromodomain and extraterminal protein inhibition impairs liver regeneration
Authors: Chen Liu, Xiawei Cheng, Juntao Chen, Yao Wang, Xiaoying Wu, Rui Tian, Baoqing Liu, Xianfeng Ding, Qiming Sun, Weihua Gong
Journal: Theranostics (2019)

Background and aims: Biological mechanisms that control liver regeneration remain poorly defined.However, these mechanisms are remarkable issues in the clinic that affect management of hepatic loss caused by liver surgery, traumatic injury, chronic infection, or liver poisoning.Increasing evidence has shown that various growth factors, cytokines, and metabolic signaling pathways affect the liver regenerative process.Our aim is to study the effect of bromodomain and extraterminal (BET) protein inhibition on liver regeneration and its mechanism.Methods: We studied the role of BET protein inhibitor, JQ1, in liver regeneration in a mouse model after 70% partial hepatectomy (PH).We evaluated yes-associated protein (YAP)/transcriptional co-activator with PDZ-binding motif (TAZ) and Notch signaling pathways, which were affected by BET protein inhibitor in mouse hepatic tissues and primary hepatocytes in vivo and AML12 cell lines in vitro.We evaluated the relationship of YAP/TAZ and Notch signaling pathway using YAP/TAZ pathway inhibitor in liver regeneration in vivo.Moreover, we analyzed the relationship of YAP/TAZ and Notch signaling pathways via overexpression or RNA silencing of Yap in AML12 cells.Furthermore, we used Yap overexpression mouse model to examine whether it can rescue liver regeneration damage caused by inhibition of BET proteins.Results: In this study, we report that BET protein inhibitor JQ1 molecule impairs the early phase of liver regeneration in a mouse model after 70% PH.Mechanistically, YAP/TAZ and Notch1-NICD pathways were suppressed by BET protein inhibitor in mouse hepatic tissues and primary hepatocytes in vivo and mouse AML12 cell lines in vitro.By using YAP/TAZ pathway inhibitor, we confirmed that the liver regeneration and the activation of Notch pathway were impaired by the inhibition of YAP/TAZ pathway in vivo.Furthermore, the study showed that Yap knockdown by shRNA in normal mouse hepatic cell line downregulated Notch1 signal transduction, whereas Yap overexpression promoted Notch1-NICD signals.Specific overexpression of Yap in mouse liver could rescue the effect of BET protein inhibition on liver regeneration injury.Conclusion: These results revealed the crucial role of the YAP/TAZ-Notch1-NICD axis in liver regeneration.Therefore, BET protein inhibitors must be used in caution in the treatment of hepatic diseases by reason of its suppressive roles in liver regeneration.
Evaluation of Patients With a History of Penicillin Allergy—Reply
Authors: Erica S. Shenoy, Kimberly G. Blumenthal
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 17116: Substrate-based Ablation Strategies Versus Standard Ablation of Ventricular Tachycardia in Patients With Structural Heart Disease: A Meta-analysis
Authors: David F Briceno, Pedro Villablanca, Florentino Lupercio, Anand Jagannath, Jignesh Patel, Alejandra Londono, Faraj Kargoli, Sanghamitra Mohanty, Prasant Mohanty, Carola Gianni, Harish Ramakrishna, Soo G Kim, Andrea Natale, Luigi Di Biase
Journal: Circulation (2016)

Background: Catheter ablation of ventricular tachycardia (VT) reduces ventricular arrhythmia recurrence in patients with structural heart disease (SHD), however the most effective catheter ablation...
Freedom isn’t always free: immunoglobulin free light chains promote renal fibrosis
Authors: Erin B. Taylor, Michael J. Ryan
Journal: Journal of Clinical Investigation (2019)

Multiple myeloma (MM) is a relatively common hematologic malignancy, and up to half of patients with MM present with renal dysfunction at the time of diagnosis. MM-associated renal injury has been linked to an excess level of monoclonal immunoglobulin free light chains (FLCs) in the circulation; however, it is not clear how these FLCs drive renal pathology. In this issue of the JCI, Ying et al. unravel a novel mechanism by which FLCs mediate renal injury in MM by inducing fibrotic and inflammatory pathways in the kidney. Specifically, FLC-mediated production of H2O2 was shown to activate JAK2/STAT1 signaling, increase production of IL-1β via induction of capsase-1, and promote activation of TGF-β via αvβ6 integrin. Moreover, the authors identified a tryptophan residue within a specific monoclonal FLC that was required for optimal H2O2 production and downstream signaling. A better understanding of the drivers of MM-associated renal injury has potential for the identification of promising therapeutic targets.
PB2183 SUPERIORITY OF CYBORD OVER VAD IS MORE EVIDENT IN FIRST THAN IN SECOND LINE TREATMENT OF MULTIPLE MYELOMA
Authors: M. El Gammal, N. Hassan, M. Abdel Fatah
Journal: HemaSphere (2019)

Background: In the era of novel anti‐myeloma agents and monoclonal antibodies (daratumumab) and due to their high cost, earlier low cost regimens (VAD or CyBorD) may be used. Aims: to compare outcome of treatment of CyBorD versus VAD regimens in multiple myeloma Methods This cohort study included 89 MM patients treated at National Cancer Institute (NCI), Cairo, Egypt from January 2011 to December 2015. All patients were evaluated clinically and laboratory for different responses with either lines of treatment (VAD versus CyBorD), and correlated with different survival parameters; progression free (PFS), disease free (DFS), and overall survival (OS), and clinico‐pathologic factors. Results: The median age of patients was 54 years (32‐76), with male predominance (male to female ratio 1.87:1). The most common presenting symptoms were bony pains (44.9%) followed by bony masses (22.5%), fractures (16.9%), pallor (7.9%), neurological symptoms (5.6%) and finally oliguria (2.2%). CyBorD have better overall response rate (≥PR) (p = 0.031), PFS (p = 0.004) and DFS (p= 0.013) as 1st line treatment compared to VAD regimen. Also in previously treated patients CyBorD showed better PFS (p = 0.039) compared to VAD regimen. There was a significant relation between age (p = 0.001&amp; &lt; 0.001) and ASCT (p= 0.001&amp;0.034) with PFS and OS respectively. Summary/Conclusion: CyBorD have significant better overall response treatment (≥PR), PFS and DFS in 1 st line treatment compared to VAD regimen. While in previously treated patients only PFS benefit for CyBorD over VAD regimen was obtained. Age and ASCT had significant effect on PFS and OS image
Genetic Markers of ADHD-Related Variations in Intracranial Volume
Authors: Marieke Klein, Raymond K. Walters, Ditte Demontis, Jason L. Stein, Derrek P. Hibar, Hieab H. Adams, Janita Bralten, Nina Roth Mota, Russell Schachar, Edmund Sonuga-Barke, Manuel Mattheisen, Benjamin M. Neale, Paul M. Thompson, Sarah E. Medland, Anders D. Børglum, Stephen V. Faraone, Alejandro Arias-Vasquez, Barbara Franke
Journal: American Journal of Psychiatry (2019)

Attention deficit hyperactivity disorder (ADHD) is a common and highly heritable neurodevelopmental disorder with a complex pathophysiology. Intracranial volume (ICV) and volumes of the nucleus accumbens, amygdala, caudate nucleus, hippocampus, and putamen are smaller in people with ADHD compared with healthy individuals. The authors investigated the overlap between common genetic variation associated with ADHD risk and these brain volume measures to identify underlying biological processes contributing to the disorder.The authors combined genome-wide association results from the largest available studies of ADHD (N=55,374) and brain volumes (N=11,221-24,704), using a set of complementary methods to investigate overlap at the level of global common variant genetic architecture and at the single variant level.Analyses revealed a significant negative genetic correlation between ADHD and ICV (rg=-0.22). Meta-analysis of single variants revealed two significant loci of interest associated with both ADHD risk and ICV; four additional loci were identified for ADHD and volumes of the amygdala, caudate nucleus, and putamen. Exploratory gene-based and gene-set analyses in the ADHD-ICV meta-analytic data showed association with variation in neurite outgrowth-related genes.This is the first genome-wide study to show significant genetic overlap between brain volume measures and ADHD, both on the global and the single variant level. Variants linked to smaller ICV were associated with increased ADHD risk. These findings can help us develop new hypotheses about biological mechanisms by which brain structure alterations may be involved in ADHD disease etiology.
Ascorbic acid induced HepG2 cells' apoptosis <i>via</i> intracellular reductive stress
Authors: Xiaonan Gao, Keyan Wei, Bo Hu, Kehua Xu, Bo Tang
Journal: Theranostics (2019)

Goals: Destruction of the redox balance in tumor cells is of great significance for triggering their apoptosis in clinical applications. We designed a pH sensitive multifunctional drug nanocarrier with controllable release of ascorbic acid under hypoxic environment to induce tumor cells' apoptosis via enhancing reductive stress, thereby dealing minimum damage to normal tissues. Methods: A core-shell nanostructure of CdTe quantum dots with mesoporous silica coating was developed and functionalized with poly(2-vinylpyridine)-polyethylene glycol-folic acid, which achieves cancer cells' targeting delivery and reversibly pH controlled release of ascorbic acid both in vitro and in vivo. Results: The result demonstrated that ascorbic acid can indeed lead liver cancer cells' death with the increase of nicotinamide adenine dinucleotide phosphate, while normal cells not being affected. The molecular mechanism of apoptosis induced by ascorbic acid was firstly elucidated at cellular levels, and further confirmed via in vivo investigations. Conclusion: For the first time we proposed the concept for applying reductive stress into cancer treatments, which brings great advantage of toxicity free and less damage to normal tissues. In general, this technique has taken an important step in the development of a targeted tumor treatment system, providing perspectives for the design of medicines via reductive stress, and offers new insights into future clinical mild-therapies.
Questions and Answers
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The immune cell landscape in kidneys of patients with lupus nephritis
Authors: Arnon Arazi, Deepak A Rao, Celine C Berthier, Anne Davidson, Yanyan Liu, Paul J Hoover, Adam Chicoine, Thomas M Eisenhaure, A Helena Jonsson, Shuqiang Li, David J Lieb, Fan Zhang, Kamil Slowikowski, Edward P Browne, Akiko Noma, Danielle Sutherby, Scott Steelman, Dawn E Smilek, Patti Tosta, William Apruzzese, Elena Massarotti, Maria Dall'Era, Meyeon Park, Diane L Kamen, Richard A Furie, Fernanda Payan-Schober, William F Pendergraft, Elizabeth A McInnis, Jill P Buyon, Michelle A Petri, Chaim Putterman, Kenneth C Kalunian, E Steve Woodle, James A Lederer, David A Hildeman, Chad Nusbaum, Soumya Raychaudhuri, Matthias Kretzler, Jennifer H Anolik, Michael B Brenner, David Wofsy, Nir Hacohen, Betty Diamond
Journal: Nature Immunology (2019)
Association of Serum Retinol-Binding Protein 4 Levels and the Risk of Incident Type 2 Diabetes in Subjects With Prediabetes
Authors: Jiahua Fan, Songping Yin, Diaozhu Lin, Yangqing Liu, Nixuan Chen, Xinxiu Bai, Qiuyi Ke, Jia Shen, Lili You, Xiuhong Lin, Feng Li, Fengyi He, Li Yan, Chaogang Chen, Min Xia
Journal: Diabetes Care (2019)

OBJECTIVE To explore the association of serum retinol-binding protein 4 (RBP4) levels and risk for the development of type 2 diabetes in individuals with prediabetes. RESEARCH DESIGN AND METHODS A population-based prospective study was conducted among 1,011 Chinese participants with prediabetes (average age 55.6 ± 7.2 years). Incident type 2 diabetes was diagnosed according to the American Diabetes Association 2010 criteria. Serum RBP4 levels were measured using a commercially available ELISA. We analyzed the association of serum RBP4 levels with the risk of incident type 2 diabetes using the Cox proportional hazards model. RESULTS During a median follow-up period of 3.1 years, 153 participants developed incident type 2 diabetes. A U-shaped association was observed between serum RBP4 levels and the risk of incident type 2 diabetes, with the lowest risk in the RBP4 range of 31–55 μg/mL. Multivariate Cox regression model analysis showed that serum RBP4 levels &amp;lt;31 μg/mL and RBP4 levels &amp;gt;55 μg/mL were associated with an increased risk of incident type 2 diabetes. The adjusted hazard ratios (95% CI) were 2.01 (1.31–3.09) and 1.97 (1.32–2.93), respectively, after adjusting for age, sex, BMI, waist circumference, γ-glutamyltransferase, HOMA of insulin resistance index, fasting plasma glucose, 2-h plasma glucose, and glycated hemoglobin (HbA1c) levels. CONCLUSIONS A U-shaped relationship exists between serum RBP4 levels and the risk of incident type 2 diabetes in subjects with prediabetes.