tbuckley/cabot-search huggingface dataset:
SAT0095 A perceived biological cause of rheumatoid arthritisonset is associated with lower levels of depressed and anxious mood over one year compared to patients who attributed onset to other causes
Authors: J. Gwinnutt, S. Verstappen, K. Hyrich, M. Lunt, A. Barton, L. Cordingley
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Patients with rheumatoid arthritis (RA) attribute onset of their condition to a range of causes including biological, psychological, work-related causes or stressful life events. Causal attributions are associated with a range of short- and long-term outcomes. <h3>Objectives</h3> To compare the 1 year outcomes of early RA patients who attribute a biological cause of onset of RA with patients who perceive non-biological causal attributions. <h3>Methods</h3> The Rheumatoid Arthritis Medication Study (RAMS) is a prospective cohort of patients with RA starting methotrexate for the first time in the United Kingdom. Demographic and clinical data (pain and fatigue visual analogue scales [VAS-pain/VAS-fatigue], disease activity [DAS28], the Hospital Anxiety and Depression Scale [HADS-A, HADS-D] and the Health Assessment Questionnaire [HAQ]) were collected at baseline and 1 year later. At baseline, patients completed the Brief Illness Perception Questionnaire (Brief IPQ), which assesses key beliefs about the impact, controllability, and chronicity of RA. The final item of the Brief IPQ asks patients to report the most important factor they believe caused their disease. These causal attributions were coded as either biological (e.g. age, genetics) or other causes (e.g. work related, stressful life event). Brief IPQ item response scores were compared between these groups using linear regression, adjusted for age and gender. HAQ, DAS28, VAS-pain, VAS-fatigue, HAD-A and HADS-D over follow-up were compared between the two groups using random effects models. <h3>Results</h3> Of 1171 patients, 483 (41.2%) reported a biological cause to be the most important factor in causing their arthritis and 688 (58.8%) reported a non-biological cause. Patients who believed in biological causes were younger (median 58 vs. 61 years; p=0.003) and more likely to be women (72.1% vs. 59.2%; p&lt;0.001). Other baseline characteristics were similar (Table). Patients who perceived biological causes reported significantly lower concerns about their illness (median: 8 vs. 9; p=0.004) and significantly lower emotional impact (median: 5 vs. 6; p&lt;0.001). Over follow-up, patients who attributed biological causes reported lower depression and anxiety HADS scores than those holding non-biological attributions (mean difference [95% CI]: HADS-D=−0.76 [-1.19,–0.33]; HADS-A=−0.94 [-1.41,–0.47]). Other outcomes over follow-up were similar. <h3>Conclusions</h3> Different causal attributions of RA are associated with different outcomes and may suggest that education about RA causality could improve patient-centred outcomes; however, that would require further evaluation. <h3>Disclosure of Interest</h3> None declared
Using artificial intelligence to assess clinicians’ communication skills
Authors: Padhraig Ryan, Saturnino Luz, Pierre Albert, Carl Vogel, Charles Normand, Glyn Elwyn
Journal: BMJ (2019)

Most doctors have never had their communication skills formally assessed and do not know how they compare with their peers. <b>Glyn Elwyn and colleagues</b> explain how AI might facilitate this and help improve interactions with patients
Abstract 209: Evaluation of Quantitative Debriefing After Cardiac Arrest
Authors: Carleen Zebuhr, Robert Sutton, Wynne Morrison, Dana Niles, Lori Boyle, Akira Nishisaki, Peter Meaney, Jessica Leffelman, Robert Berg, Vinay Nadkarni
Journal: Circulation (2011)

Introduction: Debriefing after adult cardiac arrest is effective to improve CPR quality and survival outcomes. A rigorous investigation of pediatric resuscitation debriefing programs has not been done. Objective: To describe and evaluate a multidisciplinary, peer-led, pediatric cardiac arrest quantitative debriefing (QD) program. We hypothesized that QD would improve knowledge, confidence, and competence to perform high quality pediatric resuscitation. Methods: Physician-led 60 minute multidisciplinary QDs were conducted using downloaded data from CPR recording defibrillators/central monitors and forensic engineering analysis. Following each QD, attendees completed a semi-quantitative survey. Eight QD content elements divided, a priori , into chest compression (CC) related (e.g. no flow time, CC quality, end tidal CO2, defibrillation) and non-CC related (e.g. communication, rhythm recognition, medications, arrest physiology) categories were evaluated to determine those most useful overall (5- point Likert scale: 1 = very useful / 5 = not useful). Summary scores of each category were then calculated to evaluate their impact on providers' knowledge, confidence, and competence. Analysis by Wilcoxon rank sum test. Results: Between June 2010 and May 2011, 6 QDs were completed within 21 ± 13 days of the cardiac arrest. Thirty-four of 50 (68%) front line care providers were able to attend the QD and complete surveys: RN (15%), attending MD (35%), fellow MD (26%), resident MD (9%), ECMO (6%), and RT (9%). Thirty-four (100%) reported improved knowledge and performance; 33/34 (97%) noted improved confidence. QD content had an average overall usefulness score of 1.5 ±1.0. CC related items scored higher than non-CC related items to improve knowledge (1.9 ± 1.1 vs. 1.3 ± 1.2; p&lt;0.02) and performance (2.1 ± 1.1 vs. 1.0 ± 1.2; p&lt;0.01). Conclusions: A novel Quantitative Debriefing (QD) program improved self-reported knowledge, confidence, and competence to perform high quality pediatric resuscitation. CC related QD elements were rated more useful than non-CC related elements. Future studies are planned to measure and evaluate actual clinical performance impact of QD programs.
The 3-Drug Combination Treatment ART838, ABT199 Plus Sorafenib Is Effective Against AML Xenografts, Possibly Via Cooperative Targeting of MCL1
Authors: Blake S Moses, Jennifer Fox, Xiaochun Chen, Samantha McCullough, Sang Ngoc Tran, Allison Kirkpatrick, Kalyani Kumar, Jeffrey W. Tyner, Gary H. Posner, Curt I. Civin
Journal: Blood (2018)
Abstract 16632: Gender Disparities in Use of Cardiologist Care
Authors: Xian Shen, David J Harrison, Jeetvan Patel, Michael Johnsrud, Juan Maya, Stefan DiMario
Journal: Circulation (2017)

Introduction: Health plans often use utilization management (UM) criteria to define patients for whom they will reimburse for specific therapies. In addition to clinical requirements, some UM crite...
AB0858 Impact of application of asas criteria for axial spondyloarthritis on the diagnostic delay in egyptian patients
Authors: F.I. Abdelrahman, M. Mortada
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Diagnostic delay is a major challenge in axial spondyloarthritis(SpA). The 2009 Assessment of SpondyloArthritis international Society classification(ASAS) criteria for axial SpA formally recognised the utility of MRI in diagnosis.<sup>1</sup> There are conflicting reports whether there had been any recent improvement in the period of diagnostic delay after application of ASAS criteria.<sup>2</sup> <h3>Objectives</h3> To evaluate the period from symptoms onset to diagnosis in Egyptian patients with axial SpA before and after application of ASAS criteria for axial SpA and to examine possible reasons for delayed diagnosis. <h3>Methods</h3> The study included all axial SpA patients attending a university tertiary referral centre for regular follow up in the period between May 2016 to November 2017. The patients were divided into 2 groups; group 1 included patients with a diagnosis of axial SpA before the beginning of 2010 (when ASAS criteria became widely available and in use) and group 2 included patients with a diagnosis of axial SpA after the beginning of 2010. A face-to-face interview was applied for both groups to take medical history, and a questionnaire that contains some clinical aspects of disease was used. Diagnosis delay was described as the gap between first SpA symptom and correct diagnosis of axial SpA. Clinical and functional assessment of axial SpA measured by Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Metrology Index (BASMI). The direct medical cost during years of delay (including costs of medical consultations, medications, investigations, physiotherapy and surgical treatment) had been estimated. <h3>Results</h3> As presented in table 1; more axial SpA cases were in group 2 (diagnosed after the beginning of 2010) with significantly narrower gap of delay, younger age at diagnosis, lesser number of doctor visits, lesser number of unnecessary spinal surgeries, lower total direct estimated costs and better BASDI, BASFI and BASMI. <h3>Conclusions</h3> Application of ASAS criteria for axial SpA has resulted in a significant decrease in the diagnostic gap which is reflected in a significant decrease in age at diagnosis and in the costs of unnecessary medications. On the other side, the gap is still large and more sensitive criteria are still needed. <h3>References</h3> [1] Rudwaleit M. et al: The development of Assessment of Spondyloarthritis international Society classification criteria for axial spondyloarthritis; Ann Rheum Dis, 68 (2009), pp.777–783. [2] Sykes M. et al: Diagnostic delay in patients with rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis; Ann Rheum Dis.2015;74:e44. <h3>Disclosure of Interest</h3> None declared
Abstract 19755: Statin Treatment, Genetic Inhibition of HMGCR, and Risk of Symptomatic Gallstone Disease
Authors: Faiza Qayyum, Bo K Lauridsen, Ruth Frikke-Schmidt, Børge G Nordestgaard, Anne Tybjærg-Hansen
Journal: Circulation (2017)

Introduction: In observational studies, statin treatment is associated with low risk of gallstone disease(GSD). Hypothesis: We tested the hypothesis that genetic variants in HMGCR, mimicking treatm...
Internet-delivered exposure therapy was cost-effective for increasing treatment response in fibromyalgia
Authors: Anupam Goel
Journal: Annals of Internal Medicine (2019)

Source Citation Hedman-Lagerlöf M, Hedman-Lagerlöf E, Ljótsson B, et al. Cost-effectiveness and cost-utility of internet-delivered exposure therapy for fibromyalgia: results from a randomized controlled trial. J Pain. 2018. [Epub ahead of print]. 30107241
AB0970 Investigation of the effects of balance training on balance and functional status in patients with total hip arthroplasty due to osteoarthritis: a randomised controlled pilot study
Authors: N. Elibol, B. Unver, V. Karatosun
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Osteoarthritis (OA) of the hip is one of the most common disorders in musculoskeletal system. The hip osteoarthritis is painful and this pain causes disability of various degrees, postural and gait disorders.<sup>1</sup> Total hip arthroplasty (THA) has been to one of the most frequent elective surgical procedures that can effectively reduce pain and improve the function in patient with hip OA.<sup>2</sup> It was reported that patients with coxarthrosis and THA have decreased proprioception with motor control and balance disorders, compared to healthy subjects.<sup>3</sup> The purpose of current study was to investigate the effects of balance exercises on balance and functional level with objective assessment methods until the 26th week of surgery in patients with THA. <h3>Objectives</h3> The purpose of our study is investigating of the effects of balance training on balance and functional status in patients with THA. <h3>Methods</h3> Sixteen patients with unilateral elective THA were randomised to 2 groups: conventional rehabilitation (CR, n=8) or conventional rehabilitation plus balance training (CR + BT, n=8) groups. The CR group completed typical surgery-specific joint range-of-motion and muscle strengthening exercises, while the CR + BT group completed the CR plus balance exercises during 6 weeks. The patients were evaluated by single leg stance test, Tetrax balance system, Harris hip scoring, lower extremity function scale, 5 times sit to stand test and 50-foot timed walk test preoperatively and 8, 14, and 26 weeks after THA. <h3>Results</h3> While there was significant improvement, in terms of on the right extremity eyes closed single leg stance test in the CR group (p&lt;0.05), there was no significant difference in terms of other assessment parameters between CR and CR +BT groups (p&gt;0.05). There were significant improvement after THA surgery in both groups (p&lt;0.05). <h3>Conclusions</h3> The results of our study indicate that there were similar improvements in the balance and functional parameters in the CR and CR +BT groups. There was no additional benefit of the balance exercises in balance in the 14 and 26 weeks after THP. Significiant differences could be found between groups by continuing balance training with more patients for 1–2 years following THA. <h3>References</h3> [1] Truszczynska A, Rapala K, Gmitrzykowska E, Trzaskoma Z, Drzal-Grabiec J. Postural stability disorders in patients with osteoarthritis of the hip. Acta Bioeng Biomech2014;16 (1): 45–50. [2] Sharma L. Osteoarthritis year in review 2015. Clinical Osteoarthr Cartil 2016;24 (1): 36–48. [3] Moraes MR, Cavalcante ML, Leite JA, et al. The characteristics of the mechanoreceptors of the hip with arthrosis. J Orthop Surg Res. 2011;6 (1): 58. <h3>Disclosure of Interest</h3> None declared
Genetic Gene Expression Changes during Environmental Adaptations Tend to Reverse Plastic Changes Even after the Correction for Statistical Nonindependence
Authors: Wei-Chin Ho, Jianzhi Zhang
Journal: Molecular Biology and Evolution (2019)

Abstract Organismal adaptations to new environments often begin with plastic phenotypic changes followed by genetic phenotypic changes, but the relationship between the two types of changes is controversial. Contrary to the view that plastic changes serve as steppingstones to genetic adaptations, recent transcriptome studies reported that genetic gene expression changes more often reverse than reinforce plastic expression changes in experimental evolution. However, it was pointed out that this trend could be an artifact of the statistical nonindependence between the estimates of plastic and genetic phenotypic changes, because both estimates rely on the phenotypic measure at the plastic stage. Using computer simulation, we show that indeed the nonindependence can cause an apparent excess of expression reversion relative to reinforcement. We propose a parametric bootstrap method and show by simulation that it removes the bias almost entirely. Analyzing transcriptome data from a total of 34 parallel lines in 5 experimental evolution studies of Escherichia coli, yeast, and guppies that are amenable to our method confirms that genetic expression changes tend to reverse plastic changes. Thus, at least for gene expression traits, phenotypic plasticity does not generally facilitate genetic adaptation. Several other comparisons of statistically nonindependent estimates are commonly performed in evolutionary genomics such as that between cis- and trans-effects of mutations on gene expression and that between transcriptional and translational effects on gene expression. It is important to validate previous results from such comparisons, and our proposed statistical analyses can be useful for this purpose.
Electrocoagulation of biliary papillomatosis during choledochoscopy
Authors: Xianghong Zhou, Chuncheng Wu, Chi Yuan, Bing Hu
Journal: Endoscopy (2019)

A 39-year-old woman was admitted to our hospital with pain in the right upper quadrant for more than 2 months. Magnetic resource imaging (MRI) showed that the patient had liver calcification, dilatation of the intrahepatic bile duct and upper part of the extrahepatic bile duct, and hepatic parenchymal nodules ([Fig. 1]). The patient had undergone cholecystectomy for gallstones a year previously. For further diagnosis and treatment, we decided to perform biliary exploration.
THU0178 Clinical significance of periodontitis in rheumatoid arthritis patients: association with disease activity, functional status and radiolographic score
Authors: T.A. Gheita, H.M. Fathi, N. Khairy, W.A. El-Battawy
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> <h3>Objectives</h3> To evaluate frequency of periodontitis (PD) in rheumatoid arthritis (RA) patients and relate it with clinical characteristics, disease activity, functional status, anti-cyclic citrullinated peptide (anti-CCP) and radiographic scores. <h3>Methods</h3> The study included 60 RA patients and 30 controls. Clinical Disease activity index (CDAI), Modified Health Assessment Questionnaire (MHAQ), visual analogue scale of pain and Scott's modification to Larsen scoring method were assessed. Rheumatoid factor (RF) positivity and antiCCP titer were measured. Periodontal examination was performed and relevant indeces calculated <h3>Results</h3> The mean age of the patients was 49.1±13 years and they were 52 females and 8 males. PD was present in 71.7% of RA patients versus 46.7% in control (p=0.02). PD was predominantly generalised (p=0.004) and moderate-severe degree (p=0.01). Age (p=0.007), disease duration (p&lt;0.0001), morning stiffness (p=0.01), CDAI (p&lt;0.0001), MHAQ (p=0.02), CRP (p=0.02), anti-CCP titer (p=0.01) and methotrexate treatment (p=0.005) were significantly higher in RA-PD versus RA. However, gender, smoking, oral hygiene, erythrocyte sedimentation rate, RF, anti-CCP positivity and radiographic scoring were insignificantly different. PD positivity was 96.3%, predominant generalised in 92.6%, moderate (40.7%) and severe degree (37%) in early RA versus (51.5%,24.2%,24.2%,12.1% respectively) in late RA patients. All PD indices were higher in early patients (p≤0.05) while teeth loss (p=0.03) was higher in late cases. CDAI, VAS and ACPA titer all signficantly correlated with PD indices (p&lt;0.05). <h3>Conclusions</h3> Periodontitis is frequent in RA patients' especially in early cases and is remarkably associated to disease activity and reduced functional status. <h3>Disclosure of Interest</h3> None declared
Safety of Caplacizumab for the Treatment of Patients with Acquired Thrombotic Thrombocytopenic Purpura - Results Normalized to Time of Exposure in a Double-Blind, Placebo-Controlled, Phase 3 Hercules Study
Authors: Johanna A. Kremer Hovinga, Marie Scully, Spero R Cataland, Flora Peyvandi, Paul Coppo, Paul Knöbl, Javier De La Rubia, Katerina Pavenski, Jessica Minkue, Rui Passos Sousa, Filip Callewaert, Hilde De Winter, Ara Metjian
Journal: Blood (2018)
THU0200 Subcutaneous tocilizumab in patients with rheumatoid arthritis; a high number of patients achieve doppler remission after 24 weeks
Authors: H.B. Hammer, I.M.J. Hansen, P. Jarvinen, M. Leirisalo-Repo, M. Ziegelasch, B. Agular, L. Terslev
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Clinical remission in rheumatoid arthritis (RA) is evaluated by Composite Disease Activity Scores (CDAS) including DAS28 and CDAI. Ultrasound (US) is more sensitive than clinical examination for detection of synovitis and assessed by use of Grey Scale (GS) and vascularisation by power/colour Doppler. <h3>Objectives</h3> To explore the number of patients reaching Doppler compared to CDAS remission in moderate to severe biologically naïve RA patients (pts) treated with subcutaneous tocilizumab (TCZ-SC) over 24 weeks and to evaluate the safety of TCZ-SC. <h3>Methods</h3> A regional multi-country (Denmark, Finland, Norway, Sweden) open-label, single-arm study (part of TOZURA<sup>1</sup>), enrolled pts with inadequate response to csDMARDs. Pts received TCZ-SC 162 mg qw for 24 weeks as monotherapy or in combination with a csDMARD. Stable oral NSAIDs and corticosteroids (CS) (≤10 mg/day prednisone or equivalent), were allowed. Clinical (tender and swollen joints), laboratory tests, safety assessments as well as US examination (36 joints and 4 tendons, scored according to the Norwegian US atlas<sup>2</sup>) were performed at baseline, 4, 12 and 24 weeks. US reliability between centres was assessed prior to the study. There is no consensus on definitions of Doppler remission, and Doppler sum scores of 0 to 3 were presently explored as definitions of US remission. CDAS and EULAR/ACR Boolean remission were calculated. <h3>Results</h3> 133 pts were included, and 110 pts were followed with US assessments (83% female, mean (SD) age 55.6 (12.1) years and RA duration 8.7 (9.5) years, 81% anti-CCP positive and 62% with erosive disease). All clinical, laboratory and US variables decreased significantly, already after 4 weeks (p&lt;0.001) (table 1). Table 2 illustrates the high percentages of patients reaching remission, especially for DAS28(ESR) and Doppler. Fourteen serious AE were reported in 12 pts and 15 AEs led to permanent withdrawal of treatment. <h3>Conclusions</h3> This open label study showed TCZ-SC to significantly reduce inflammation assessed by both CDAS and Doppler US. A high number of pts (53%–79%) obtained Doppler remission at 24 weeks using the different definitions. The safety profile was similar to what has previously been reported. <h3>References</h3> [1] EULAR 2017Abstract SAT0199. [2] Hammer HB, et al. ARD2011. <h3>Disclosure of Interest</h3> None declared
ACC/AHA 2008 Guideline Update on Valvular Heart Disease: Focused Update on Infective Endocarditis
Authors: Rick A. Nishimura, Blase A. Carabello, David P. Faxon, Michael D. Freed, Bruce W. Lytle, Patrick T. O'Gara, Robert A. O'Rourke, Pravin M. Shah
Journal: Journal of the American College of Cardiology (2008)
Rivaroxaban, Aspirin, or Both to Prevent Early Coronary Bypass Graft Occlusion
Authors: Andre Lamy, John Eikelboom, Tej Sheth, Stuart Connolly, Jackie Bosch, Keith A.A. Fox, Jun Zhu, Eva Lonn, Gilles Dagenais, Petr Widimsky, Kelly R.H. Branch, Deepak L. Bhatt, Zhe Zheng, Zbynek Straka, Francois Dagenais, Ye Kong, Tamara Marsden, Shun Fu Lee, Ingrid Copland, Salim Yusuf
Journal: Journal of the American College of Cardiology (2019)