tbuckley/cabot-search huggingface dataset:
David Henry Green
Authors: Pauline Green
Journal: BMJ (2019)

David Green was born in October 1951 at home in Stoke on Trent, the first born of undiagnosed twins. His brother, Terence, followed soon after much to his mother’s shock and delight. David and Terence went to St Joseph’s College in Stoke on Trent, and the two boys then followed their elder brother Michael to Liverpool University.

David studied mathematical statistics and computational science and received his BSc in 1974. Not satisfied with a first degree he continued his studies and was awarded a PhD in 1977; this was entitled “Stochastic models for cell growth on a 2-D regular lattice.” During his studies he presented his work at international conferences, including the European Meeting of Statisticians in Grenoble and the Royal Statistical Society. Despite his undisputed talents in computational science, David followed his heart and started training in medicine in 1977. He fought hard for a place in medical school, and with no financial help available, he had to work long hours to earn enough money to fund the first two non-clinical years. Despite the exhaustion of studying and working, he passed his examinations and progressed to the clinical years, when he …
Cohort profile: the Barwon Infant Study
Authors: P Vuillermin, J Carlin, M Tang, R Saffery, K Allen, S Ranganathan, D Burgner, T Dwyer, Ponsonby A-L., Grp Bisi.
Journal: Allergy (2013)

The modern environment is associated with an increasing burden of non-communicable diseases (NCDs). Mounting evidence implicates environmental exposures, experienced early in life (including in utero), in the aetiology of many NCDs, though the cellular/molecular mechanism(s) underlying this elevated risk across the life course remain unclear. Epigenetic variation has emerged as a candidate mediator of such effects. The Barwon Infant Study (BIS) is a population-derived birth cohort study (n = 1074 infants) with antenatal recruitment, conducted in the south-east of Australia (Victoria). BIS has been designed to facilitate a detailed mechanistic investigation of development within an epidemiological framework. The broad objectives are to investigate the role of specific environmental factors, gut microbiota and epigenetic variation in early-life development, and subsequent immune, allergic, cardiovascular, respiratory and neurodevelopmental outcomes. Participants have been reviewed at birth and at 1, 6, 9 and 12 months, with 2- and 4-year reviews under way. Biological samples and measures include: maternal blood, faeces and urine during pregnancy; infant urine, faeces and blood at regular intervals during the first 4 years; lung function at 1 month and 4 years; cardiovascular assessment at 1 month and 4 years; skin-prick allergy testing and food challenge at 1 year; and neurodevelopmental assessment at 9 months, 2 and 4 years. Data access enquiries can be made at [www.barwoninfantstudy.org.au] or via [peter.vuillermin@deakin.edu.au].
H1N1 RELATED ACUTE RESPIRATORY DISTRESS SYNDROME IN A PATIENT WITH SEVERE MITRAL STENOSIS: EXTRA CORPOREAL MEMBRANE OXYGENATION AND BALLOON MITRAL VALVULOPLASTY TO THE RESCUE
Authors: Jignesh A. Patel, Abhinav Saxena, Karan Wats, Adnan Sadiq, Gregory Crooke
Journal: Journal of the American College of Cardiology (2019)
HIGH RIGHT ATRIAL PRESSURE AND BLEEDING EVENTS IN ORALLY ANTICOAGULATED PATIENTS WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION
Authors: Lore Schrutka, Benjamin Seirer, Franz Duca, Christina Binder, Daniel Dalos, Christian Nitsche, Andreas Kammerlander, Stefan Aschauer, Klaus Distelmaier, Marianne Gwechenberger, Heinz Goessinger, Christian Hengstenberg, Julia Mascherbauer, Diana Bonderman
Journal: Journal of the American College of Cardiology (2019)
POST-STENTING RESTING PD/PA IS A STRONG PREDICTOR OF MAJOR ADVERSE CARDIOVASCULAR EVENTS AFTER PERCUTANEOUS CORONARY REVASCULARIZATION
Authors: Kulin Shah, Srikanth Kasula, Yalcin Hacioglu, Shiv Kumar Agarwal, Sabha Bhatti, Bobby Ghosh, Barry Uretsky, Abdul Hakeem
Journal: Journal of the American College of Cardiology (2019)
The influence of breathhold on peak expiratory flow in normal and asthmatic children
Authors: I. Matsumoto, S. Walker, P. D. Sly
Journal: European Respiratory Journal (1996)

We have previously demonstrated a 10% reduction in peak expiratory flow (PEF) in healthy adults following a breathhold at total lung capacity (TLC). This fall was attributed to dissipation of airway wall viscoelasticity, increasing airway wall compliance (Caw). To investigate this phenomenon in children and to determine whether the effect of breathhold would be greater in asthmatics than in normal children, 15 asthmatics and 14 normal children (aged 10-15 yrs) performed maximal post expirations (MFE) with and without a 5 s breathhold at TLC. The entire study was repeated following the inhalation of salbutamol (800 micrograms) to relax the airway smooth muscle (and to increase Caw). Breathhold at TLC resulted in a significant decrease in PEF both in the asthmatics (group mean fall 5.8%; p &lt; 0.01) and normal children (group mean fall 10.3%; p &lt; 0.05). Salbutamol diminished this fall, becoming nonsignificant in the normal children. Similar patterns were also seen in forced expiratory volume in one second (FEV1) and in maximal expiratory flow at 50% vital capacity (V'50). These data are consistent with the proposal that breathhold at total lung capacity dissipated viscoelastic energy (increasing airway compliance) and decreased maximal expiratory flows both in normal and asthmatic children. They also demonstrate the need to standardize the forced vital capacity manoeuvre to decrease the variability in the flows recorded during the subsequent forced expiration.
A REAL-WORLD ASSESSMENT OF RISK FOR SEVERE STROKE AND POST-STROKE MORTALITY IN NON-VALVULAR ATRIAL FIBRILLATION PATIENTS TREATED WITH RIVAROXABAN AND WARFARIN
Authors: Mark Alberts, Yen-Wen Chen, Jennifer Lin, Zhijie Ding, Deepti Bisht, Emily Kogan, Kathryn Twyman, Dejan Milentijevic
Journal: Journal of the American College of Cardiology (2019)
A Case for n-of-1 Trials
Authors: Alexander K. Smith
Journal: JAMA Internal Medicine (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
HOME AEDS FOR CHILDREN WITH CARDIAC CONDITIONS ASSOCIATED WITH INTERMEDIATE RISK FOR SUDDEN CARDIAC DEATH: A COST-EFFECTIVENESS ANALYSIS
Authors: Meredith Boulos, Alyssa Hersh, David Toffey, James Sargent, Eric Stecker, Stephen Heitner, Aaron Caughey, Seshadri Balaji
Journal: Journal of the American College of Cardiology (2019)
Long-Term Follow-up with GS-4059, a Selective Irreversible BTK Inhibitor, in Patients with Relapsed and Refractory Chronic Lymphocytic Leukemia
Authors: Harriet S. Walter, Sandrine Jayne, Simon A. Rule, Guillaume Cartron, Franck Morschhauser, Christopher Fegan, Yingsi Yang, Siddhartha Mitra, Martin J.S. Dyer, Gilles A. Salles
Journal: Blood (2016)
Abstract 212: Adrenergic Signaling Genes Are Not All Expressed During Myogenesis in Individual Human iPSC-derived Cardiomyocytes
Authors: David Torres Barba, Eliseo T Vazquez, Janhavi S Sharma, Elizabeth Cortez-Toledo, Omar De la Cruz Cabrera, Javier E Lopez
Journal: Circulation Research (2018)

Background: Adrenergic receptors (AR) in an individual cardiomyocyte (CM) are not uniformly expressed at the single-cell level (Myagmar et al., 2017). The timing and cellular distribution of AR signaling (ARS) genes in individual human iPSC-derived CMs (hiPSC-CMs) have not yet been reported. Objective: To map out the transcription program of ARS genes during hiPSC-CM myogenesis using single-cell transcriptomics (scRNA Seq.). Methods: 132 ARS in CM genes curated by the Kyoto Encyclopedia of Genes and Genomes were studied. The CMs were derived from 2 commercially available hiPSC lines using sequential GSK3 and Wnt signaling inhibition. The CMs were assayed by flow cytometry with sarcomeric myosin heavy chain (MYHC6/7) protein, a biomarker of myogenesis. Baseline cells (iPSCs, n=24) and day 14 (n=45), 30 (n=64), and 60 (n=5) post differentiation cells were sampled for scRNA Seq. using the Fluidigm C1 platform. Data from 10 somatic cell preparations and iPSCs defined the signal specificity and biological noise in the system. The expression patterns were categorized as induced, repressed, or neither based on the median transcript per million for individual cells normalized to iPSCs. A p -value of &lt;0.05 by ANOVA was used for significance. Results: The CMs had spontaneous contractions by D14 and increased from &lt;1% in iPSCs to 21%, 37% and 59% at D14, D30 and D60 post differentiation (adj. p &lt;0.03) respectively. None of the iPSCs had MYH6/7 transcripts, while &gt;90% of differentiating cells did. MYH6/7 median expression increased 15-fold from D14 to D30 (p&lt;0.0001) and 60-fold to D60 (p&lt;0.06). Of 132 ARS genes, 60 (44%) had no detectable expression out to D60. Of the 72 genes with expression, 18 (25%) were induced in parallel to MYH6/7, while 22 (31%) were repressed. The remaining 32 genes (44%) had no distinctive pattern. From 18 induced genes (14% of all), 8 were sarcomeric genes that preceded expression to most ARS genes without induction (86% of all). Conclusion: Single-cell transcriptomes in derived hiPSC-CMs revealed a lack of uniformity between upstream ARS genes and early sarcomeric genes. Defining the timing and cell-to-cell variability of the ARS gene program will be critical to understanding its mechanistic relationship to the sarcomeric gene program in humans.
VALUE OF TRANSLUMINAL ATTENUATION GRADIENT FROM CORONARY CTA TO IDENTIFY VESSEL-SPECIFIC CORONARY ISCHEMIA: RESULTS FROM THE PROSPECTIVE, MULTICENTER, INTERNATIONAL CREDENCE TRIAL
Authors: Alexander van Rosendael, Inge van den Hoogen, Jung Hyun Choi, So-Yeon Choi, Joon-Hyung Doh, Ae-Young Her, Bon-Kwon Koo, Chang-Wook Nam, Sanghoon Shin, Jason Cole, Alessia Gimelli, Muhammad Khan, Bin Lu, Faisal Nabi, U. Joseph Schoepf, Randall Thompson, Hyuk-Jae Chang, Philippe Genereux, Paul Knaapen, Gianluca Pontone, Wijnand Stuijfzand, Fay Lin, Leslee J. Shaw, James Min
Journal: Journal of the American College of Cardiology (2019)
EFFICACY OF PERCUTANEOUS RENAL DENERVATION VERSUS SHAM PROCEDURES IN RESISTANT HYPERTENSION: A META-ANALYSIS OF FIVE SHAM CONTROLLED CLINICAL TRIALS
Authors: Fnu Hafeez Hassan, Philip C. Wiener, Muhammed Shahzeb Khan, Gregg Pressman, Janani Rangaswami, Sanjog Kalra, Sumeet Mainigi, Christian Witzke, Jon George, Sean Janzer
Journal: Journal of the American College of Cardiology (2019)
HLA and HNA Antibodies Are More Prevalent in Multiparous Women with Red Blood Cell Alloimmunization
Authors: Juliana Oliveira Martins, Elyse Moritz, Samira Abbas, Larissa Barbosa Lopes, Dante Langhi, Akemi Kuroda Chiba, Melca Oliveira Barros, Carlos Chiattone, Jose Orlando Bordin
Journal: Blood (2017)
Weight Loss Interventions in Adults
Authors: Adam G. Tsai, Caroline Apovian, Lee Kaplan
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 231: Identification of a <i>Titin</i> Enhancer using hiPSC-Derived Cardiomyocytes and CRISPR/Cas9 Genome Editing
Authors: Meraj Neyazi, Manuel Schmid, Arun Sharma, Lauren K Wasson, Joshua M Gorham, Steven DePalma, Seong Won Kim, Jonathan G Seidman, Christine E Seidman
Journal: Circulation Research (2018)

Dilated cardiomyopathy (DCM), a disorder that occurs in 1:250 individuals, is associated with rates of mortality of 20% within 5 years of diagnosis and is a leading cause for heart failure and cardiac transplantation. Mutations in the massive sarcomere protein titin (encoded by TTN ) are the most common genetic cause of DCM, occurring in 10-20% of cases. As dominant DCM mutations truncate titin (TTNtv) and result in haploinsufficiency, we predict that strategies to increase the expression of the wild type (WT) TTN allele might attenuate the damaging effects of TTNtv. We used bioinformatic analyses to identify a putative TTN enhancer within intron 1. To confirm its function, we deleted 658 bp from intron 1 that encompasses the putative TTN enhancer in human induced pluripotent stem cells (hiPSCs) using CRISPR/Cas9 genome editing. We used qPCR and RNA sequencing of RNA harvested from hiPSC-derived cardiomyocytes (hiPSC-CMs) and demonstrated that a homozygous deletion in this region leads to decreased TTN gene expression compared to the WT control (0.344 fold change, p &lt; 0.001), and also to decreased expression of other sarcomeric genes such as TNNT2 (0.074 fold change, p &lt; 0.001), MYH6 (0.18 fold change, p &lt; 0.001), MYH7 (0.008 fold change, p &lt; 0.001), and ACTN2 (0.118 fold change, p &lt; 0.001). The expression of transcription factors (TF) that have binding sites in this region is also affected, such as MEIS2 (0.4 fold change, p &lt; 0.001) and KLF6 (0.33 fold change, p &lt; 0.001), both of which are known to be involved in cardiogenesis. These TF may act as a link between the deletion in TTN Intron 1 and a decreased transcription of other cardiac-relevant genes. We also utilized Assay for Transposase-Accessible Chromatin Sequencing (ATAC-Seq) on WT hiPSC-CMs to identify open regions of chromatin that are accessible for TF binding. This provided additional evidence that this 658 bp region in TTN intron 1 has enhancer activity. Ongoing studies are aiming to refine the TTN Intron 1 enhancer by further studies using CRISPR/Cas9, CRISPR droplet sequencing (CROP-Seq), and luciferase-based enhancer activity assays. If confirmed, we expect that increasing the activity of this 658 bp region with small molecules may provide a novel therapeutic target for DCM caused by TTNtv.
IMPLEMENTATION OF CORONARY ARTERY PHANTOM WITH ARTIFICIAL HYPEREMIA AND ANALYSIS OF PRESSURE AND FLOW VELOCITY DEPENDING ON THE DEGREE OF STENOSIS
Authors: Soohong Min, Cheongah Lee, Jooho Lee, Gwansuk Kang, Dong-Guk Paeng, Joon Hyouk Choi
Journal: Journal of the American College of Cardiology (2019)
HIGH PREVALENCE OF RHEUMATIC HEART DISEASE IN 2603 SCHOOL CHILDREN IN NORTH-WEST INDIA WITH 6 MONTHS AND 2 YEARS FOLLOW-UP: AN ECHOCARDIOGRAPHIC SURVEY
Authors: Raja Babu Panwar, Bal Kishan Gupta, Arvind Kumar Sharma, Dinesh Choudhary, Sadik Panwar, Nidhi Priya, Rajeev Gupta
Journal: Journal of the American College of Cardiology (2019)
Inhibition of Sialylation Impairs Adhesion on Madcam-1 and E-Selectin and Sensitize Multiple Myeloma Cells to Bortezomib in a Xenograft Mouse Model
Authors: Alessandro Natoni, Mariah Farrell, Heather Fairfield, Lucy Kirkham-McCarthy, Matt Macauley, Michaela Reagan, Michael E O'Dwyer
Journal: Blood (2018)
ASSOCIATION BETWEEN FREQUENCY OF PCP VISITS AND EVIDENCE-BASED STATIN PRESCRIBING AND STATIN ADHERENCE: FINDINGS FROM THE VETERANS AFFAIRS NATIONAL DATABASE
Authors: Sarah Ahmed, Hasan Rehman, Julia Akeroyd, Khurram Nasir, Mahboob Alam, Dhruv Mahtta, Salim Virani
Journal: Journal of the American College of Cardiology (2019)
DIRECT PLANIMETRY OF LEFT VENTRICULAR OUTFLOW TRACT AREA BY SIMULTANEOUS BIPLANE IMAGING: CHALLENGING THE NEED FOR A CIRCULAR ASSUMPTION OF LEFT VENTRICULAR OUTFLOW TRACT AREA IN CALCULATING AORTIC VALVE AREA
Authors: Shiying Liu, Lanqi Hua, Xin Zeng, Jessica Churchill, Tony Dong, Jacob Dal-Bianco, Jonathan Passeri, Robert Levine, Judy Hung
Journal: Journal of the American College of Cardiology (2019)
CENTRAL HYPERTENSION IN PATIENTS WITH THORACIC AORTIC ANEURYSMS WITHOUT ESTABLISHED DIAGNOSIS OF HYPERTENSION: PREVALENCE AND ASSOCIATION WITH ANEURYSM SIZE
Authors: Jasjit Rooprai, Munir Boodhwani, Luc Beauchesne, Kwan-Leung Chan, Carole Dennie, Sudhir Nagpal, Thais Coutinho
Journal: Journal of the American College of Cardiology (2019)
ROLE OF CARDIOPULMONARY TEST PERFORMANCE IN POST-AORTIC VALVE REPLACEMENT PATIENTS, RELATIONSHIP WITH ECHOCARDIOGRAPHIC PARAMETERS, AND CLINICAL OUTCOMES
Authors: Sonia Fortin, Vuyisile Nkomo, Debora Brala, Maria I. Barillas Lara, Yazan Assaf, Amanda Bonikowske, Thomas Allison
Journal: Journal of the American College of Cardiology (2019)
Self-reported Quality of Life at Middle School Age in Survivors of Very Preterm Birth
Authors: Barbara Schmidt, Peter J. Anderson, Elizabeth V. Asztalos, Lex W. Doyle, Ruth E. Grunau, Diane Moddemann, Robin S. Roberts
Journal: JAMA Pediatrics (2019)

Self-reported Quality of Life at Middle School Age in Survivors of Very Preterm Birth: Results From the Caffeine for Apnea of Prematurity Trial Data on health-related quality of life are sparse for children who were born very preterm during the past 2 decades and limited to single countries. 1,2 We studied the self-reported quality of life in an international cohort of 11-year-old children with birth weights of 500 to 1250 g.Methods | From May 7, 2011, to May 27, 2016, we performed an 11-year follow-up of Canadian, Australian, British, and Swedish participants in the Caffeine for Apnea of Prematurity trial. 3 As reported previously, 3 neonatal caffeine therapy was associated with a reduced risk of motor impairment at middle school age.During this 11-year follow-up, the children were invited to complete Kidscreen-52, a generic, healthrelated quality-of-life questionnaire for children and adolescents. 4,5 The research ethics boards of all 13 centers where this instrument
Eltrombopag for Enhancement of Platelet Engraftment in Patients Undergoing Allogeneic Cord Blood Transplantation
Authors: Oren Pasvolsky, Liat Shargian, Uri Rozovski, Ron Ram, Michael Y. Shapira, Moshe Israeli, Liat Vidal-Fisher, Ofer Shpilberg, Pia Raanani, Moshe Yeshurun
Journal: Blood (2018)
Abstract 463: Signature of Circular RNAs in Human Induced Pluripotent Stem Cells and Derived Cardiomyocytes
Authors: Wei Lei, Tingting Feng, Xing Fang, You Yu, Junjie Yang, Zhen-Ao Zhao, Junwei Liu, Zhenya Shen, Wenbo Deng, Shijun Hu
Journal: Circulation Research (2018)

Background: Circular RNAs (circRNAs) are regarded as a novel class of noncoding RNA regulators. Although a number of circRNAs have been identified by bioinformatics analysis of RNA-seq data, the tissue- and disease-specific circRNAs are still to be uncovered to promote their application in basic research and clinical practice. The purpose of this study was to explore the circRNA profiles in human induced pluripotent stem cells (hiPSCs) and hiPSC-derived cardiomyocytes (hiPSC-CMs), and identify cardiac or disease-specific circRNAs. Methods: Human iPSCs were generated from fibroblasts, and then further differentiated to hiPSC-CMs by modulating WNT signaling in RPMI+B27 medium. Following high-throughput RNA sequencing, circRNAs were extracted and quantified by a combined strategy known as CIRCexplorer. Integrative analysis was performed to illuminate the correlation between circRNAs and their parental linear isoforms. Cardiac and disease-specific expression of circRNAs was confirmed by quantitative reverse-transcription PCR. Results: In this study, a total of 5602 circRNAs were identified in hiPSCs and hiPSC-CMs. Our data indicated, for the first time, a more enriched expression of circRNAs in differentiated cardiomyocytes than undifferentiated hiPSCs. In addition to the host gene-dependent expression, our integrative analysis also identified a number of circRNAs showing host gene-independent expression in hiPSCs and hiPSC-CMs. CircRNAs including circSLC8A1 , circCACNA1D , circSPHKAP and circALPK2 showed a cardiac-selective expression during cardiac differentiation and human heart-specific enrichment in fetal tissues. Furthermore, circSLC8A1 abnormally increased in heart tissues from patients suffering from dilated cardiomyopathy (DCM). Conclusions: CircRNAs are highly enriched in hiPSC-differentiated CMs, and cardiac-specific circRNAs such as circSLC8A1 , circCACNA1D , circSPHKAP and circALPK2 may serve as biomarkers of CMs. Detection of the excessive expression of circSLC8A1 provides a potential approach for pathological status indication of heart disease.
CARDIOMEMS PREDICTS HEART FAILURE DECOMPENSATION FROM RECENT ONSET FREQUENT PREMATURE VENTRICULAR COMPLEXES: IMPROVEMENT IN PULMONARY ARTERY PRESSURE AND SYMPTOMS AFTER RADIOFREQUENCY ABLATION
Authors: Sharon Man, Merzaka Lazdam, Louise Clayton, Ian Loke, Riyaz Somani
Journal: Journal of the American College of Cardiology (2019)
New Applications of Old Drugs as Novel Therapies in Idiopathic Pulmonary Fibrosis. Metformin, Hydroxychloroquine, and Thyroid Hormone
Authors: Edward P. Manning, Ashley Losier, Nkiruka Emeagwali, Changwan Ryu, Shyoko Honiden
Journal: American Journal of Respiratory and Critical Care Medicine (2019)

The current paradigm of the pathogenesis of idiopathic pulmonary fibrosis (IPF) indicates that persistent injury to alveolar epithelial cells (AECs) results in the activation of aSMA (a-smooth muscle actin)-expressing myofibroblasts (1).Although no single mouse model fully recapitulates the human IPF disease state, the bleomycin-induced lung injury model remains the most widely accepted method of translational research despite its limitations, which include a paucity of histological findings of usual interstitial pneumonia and the lack of collagen cross-linking, resulting in reversible fibrosis (2, 3).Therapies that reverse pulmonary fibrosis remain elusive and represent a significant, unmet clinical need; we present three novel studies that highlight recent developments in IPF translational research that forges a path for an innovative approach in treating IPF through the novel application of three well-known drugs.n
ASSOCIATION BETWEEN ATRIAL SEPTAL DEFECTS AND EMBOLIC CEREBROVASCULAR EVENTS IN ADULT PATIENTS ADMITTED FOR ACUTE PULMONARY EMBOLISM
Authors: Gbolahan Ogunbayo, Elliott Goodwin, Robert Pecha, Naoki Misumida, Ayman Elbadawi, Samy-Claude Elayi, Ahmed Abdel-Latif, Andrew Leventhal, Adrian Messerli, Susan Smyth
Journal: Journal of the American College of Cardiology (2019)