tbuckley/cabot-search huggingface dataset:
New Evidence That the Bioactive Lipid Ceramide-1-Phosphate (C1P) Is a Potent Chemoattractant for Mesenchymal Stromal Cells (MSC), Endothelial Progenitor Cells (EPCs) and Very Small Embryonic-Like Stem Cells (VSELs), Demonstrating Its Potential Involvement in Tissue/Organ Repair and Angiogenesis
Authors: ChiHwa Kim, Rui Liu, Magda Kucia, Mariusz Z Ratajczak
Journal: Blood (2011)
Inhibition of Interleukin-6 Signaling with CNTO328 Sensitizes Multiple Myeloma Cells to Bortezomib and Attenuates Proteasome Inhibitor-Mediated Induction of the Anti-Apoptotic Heat Shock Protein Response.
Authors: Peter M. Voorhees, Deborah J. Kuhn, George W. Small, John S. Strader, Robert Corringham, Mohamed H. Zaki, Jeffrey Nemeth, Robert Z. Orlowski
Journal: Blood (2005)
Epidermal growth factor receptor (EGFR) expression and KRAS mutations in penile squamous cell carcinoma: Analysis of potential application of anti-EGFR monoclonal antibodies.
Authors: Hongfeng Gou, Jiyan Liu, Xiang Li, Meng Qiu, Ke Cheng, Feng Bi, Feng Xu
Journal: Journal of Clinical Oncology (2012)

4638 Background: Penile squamous cell carcinoma (SCC) is a rare cancer with poor prognosis and limited response to conventional chemotherapy. Anti-EGFR monoclonal antibodies (mAbs) have exhibited significant anti-tumor activities in several cancers such as colorectal carcinoma, head and neck cancer. KRAS mutations are linked to a poor response to mAbs and may thereby result in resistance to anti-EGFR agents. This study was aimed to examine EGFR expression and KRAS, BRAF mutations in penile SCC and to analyze the potential application of anti-EGFR monoclonal antibodies (mAbs) for this disease. Methods: Totally 150 penile SCC specimens from patients undergone surgical resection were included. EGFR expression was evaluated by immunohistochemistry. KRAS mutations at codons 12 and 13, and the BRAF mutation at codon 600 were analyzed on DNA isolated from formalin fixed paraffin embedded tissues by direct genomic sequencing. Results: EGFR expression was positive in all specimens, and its overexpression rate was 92%. We failed to observe a significant correlation between EGFR expression and tumor grade or lymph node metastases. The detection of KRAS and BRAF mutations analysis were performed in 94 and 83 tumor tissues, respectively. KRAS mutation was detected in only one sample and no patient was found to harbor BRAF V600E point mutation. Conclusions: We found the overexpression of EGFR and the absence of KRAS and BRAF mutations in penile SCC. This suggests that anti-EGFR mAbs may be potentially considerable therapeutic agents in penile SCC.
Insurance Networks and Access to Affordable Cancer Care
Authors: Kenneth L. Kehl, Nancy L. Keating, Sharon H. Giordano, Deborah Schrag
Journal: Journal of Clinical Oncology (2019)

Article Tools REVIEW ARTICLES Health Services and Outcomes Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.19.01484 Journal of Clinical Oncology - published online before print December 5, 2019 PMID: 31804867 Insurance Networks and Access to Affordable Cancer Care Kenneth L. Kehl, MD, MPH1xKenneth L. KehlSearch for articles by this author; Nancy L. Keating, MD, MPH2xNancy L. KeatingSearch for articles by this author; Sharon H. Giordano, MD, MPH3xSharon H. GiordanoSearch for articles by this author; and Deborah Schrag, MD, MPH1xDeborah SchragSearch for articles by this author Show More 1Dana-Farber Cancer Institute, Boston, MA2Harvard Medical School and Brigham and Women’s Hospital, Boston, MA3The University of Texas MD Anderson Cancer Center, Houston, TX https://doi.org/10.1200/JCO.19.01484 First Page Full Text PDF Figures and Tables © 2019 by American Society of Clinical Oncology
Immunological and Clinical Responses in Patients with Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS), Multiple Myeloma (MM) and Chronic Lymphocytic Leukemia (CLL) after RHAMM-R3 Peptide Vaccination.
Authors: Jochen Greiner, Anita Schmitt, Krzysztof Giannopoulos, Jinfei Chen, Marlies Goetz, Markus Rojewski, Gerd Ritter, Sascha Gnjatic, Philippe Guillaume, Mark Ringhoffer, Martin Bommer, Richard F. Schlenk, Peter Liebisch, Donald Bunjes, Hiroshi Shiku, Hartmut Dohner, Michael Schmitt
Journal: Blood (2007)
Long-term primary results of accelerated partial breast irradiation after breast-conserving surgery for early-stage breast cancer: a randomised, phase 3, equivalence trial
Authors: Frank A Vicini, Reena S Cecchini, Julia R White, Douglas W Arthur, Thomas B Julian, Rachel A Rabinovitch, Robert R Kuske, Patricia A Ganz, David S Parda, Michael F Scheier, Kathryn A Winter, Soonmyung Paik, Henry M Kuerer, Laura A Vallow, Lori J Pierce, Eleftherios P Mamounas, Beryl McCormick, Joseph P Costantino, Harry D Bear, Isabelle Germain, Gregory Gustafson, Linda Grossheim, Ivy A Petersen, Richard S Hudes, Walter J Curran, John L Bryant, Norman Wolmark
Journal: The Lancet (2019)
Clinical Outcome of 640 Children with Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Treated Between 1995 and 2005
Authors: Maurizio AricÃ², Martin Schrappe, Stephen Hunger, William L. Carroll, Valentino Conter, Paola Di Lorenzo, Atsushi Manabe, Vaskar Saha, Andre Baruchel, Kim Vettenranta, Masahiro Tsuchida, Yves Benoit, Rob Pieters, Gabriele Escherich, Lewis B. Silverman, Ching-Hon Pui, Maria Grazia Valsecchi
Journal: Blood (2008)
Pre-exposure prophylaxis uptake and early continuation among pregnant and post-partum women within maternal and child health clinics in Kenya: results from an implementation programme
Authors: John Kinuthia, Jillian Pintye, Felix Abuna, Kenneth K Mugwanya, Harison Lagat, Dickens Onyango, Emily Begnel, Julia Dettinger, Jared M Baeten, Grace John-Stewart, Ajode C Aquino, Steve J Ochieng, Alice M Lipesa, Ambia L Naidu, Anastacia Kamau, Anne W Njoroge, Bernard O Okeah, Cecilia B Makabwa, Celestine C Atieno, Christine K Ireri, Diana A Ojowi, Elizabeth S Lubembe, Emma Mukenyi, Emma J A Kephas, Esther N Bundi, Eunita I A Akim, Fredrick O Otieno, George R Owiti, Irene Cherotich, Irene A Ouma, Jacqueline Q Adhiambo, Joel A Otieno, Joseph M Mwendwa, Joyness B Kemunto, Magdalene C Rono, Martin C Ndung'u, Mary I A Osama, Maurine A Odhiambo, Melvin A Kiche, Meridah M Mwania, Neera Bhatt, Osama M Auma, Paskal O Otieno, Pauline Achieng, Peris W Muthoni, Rose K Chiira, Serede M Mmbukane, Sila J Mwania, Steve J Ochieng, Titus Kipyegon, Tonny O Ochieng, Valarie A Kemunto, Veronica A Odede, Vivian A Obote, Winnie N Mituga, Yvonne F Fondo
Journal: The Lancet HIV (2019)
Acute paraplegia in a healthy child
Authors: Abul Kalam Muzibul Haque, Rajesh Bagtharia, Jeewan Rawal
Journal: BMJ (2019)

A previously healthy 12 year old girl presented to the emergency department with two days of bilateral leg pain and the inability to walk.

She had no history of trauma, back pain, weight loss, night sweats, cough, or fever. She was born in India and moved to the UK at one year of age.

Clinical assessment showed a well child, with a non-tender mid thoracic swelling of the spine, and neurological examination showed upper motor neurone weakness of both legs.

She developed urine retention 24 hours after presentation. Radiographs of the chest showed a soft tissue swelling …
Case 29-1990
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, David S. Chapin, Jana C. Sullinger
Journal: New England Journal of Medicine (1990)

Presentation of CaseA 43-year-old woman was admitted to the hospital because of low-back pain and a presacral mass.The patient was well until seven months earlier, when increasing pain developed in the left buttock; the pain was aggravated during her menses and by sitting and was improved on recumbency. A computed tomographic (CT) scan of the abdomen and pelvis, performed elsewhere, was reported to show a mass behind the uterus, just to the left of the midline, with extension around the rectum. An intravenous urographic examination was reported to show a pelvic mass with localized narrowing of the left . . .
Evaluation of mobile gamma camera imaging in sentinel lymph node biopsy for melanoma independent of pre-operative lymphscintigraphy.
Authors: Joshua Marshall Judge, Craig L. Slingluff, Lynn Thacher Dengel, Mark Williams, Kosta Popovic
Journal: Journal of Clinical Oncology (2012)

e19062 Background: Sentinel lymph node biopsy (SLNB) is the standard method for staging cutaneous melanoma and involves identifying the first node(s) draining a tumor, by detecting an intradermally-injected radioactive colloid tracer. Intra-operatively the sentinel node(s) are identified with a hand-held gamma probe. Pre-operative lymphoscintigraphy is obtained to identify draining lymph node basins, but requires coordinating schedules between nuclear medicine and the operating room. A pilot study utilizing Mobile Gamma Camera (MGC) devices in conjunction with conventional lymphoscintigraphy for intraoperative sentinel node localization provided clinical benefit in 20% of patients. However, utilizing MGC devices to localize lymph node basins at the time of surgery independent of conventional lymphoscintigraphy with a fixed gamma camera (FGC) has not been adequately studied. Here, we present the results of a clinical trial utilizing MGC devices to localize lymph node basins in a manner blinded to the FGC images in order to compare the modalities directly. Methods: In 2011-12 18 patients underwent Tc99 sulfur colloid lymphoscintigraphy, and MGC survey immediately pre-operative by the study surgeon. The study surgeon established an operative plan using the MGC survey, while blinded to lymphoscintigraphy results. SLNB was then performed with use of a gamma probe and intra-operative MGC imaging. Results: 22 lymph node basins were detected in 18 imaged patients by lymphoscintigraphy. All of these basins were identified by the study surgeon using the MGC device in the pre-operative setting prior to un-blinding. In every case the operative plan established based on pre-operative MGC imaging was confirmed by the FGC images. In two cases, additional information from the MGC images aided surgical decision-making. 5 of 22 lymph node basins were positive for metastasis. All of these basins were identified by pre-operative MGC imaging, and all individual positive nodes were identified by intra-operative MGC imaging. Conclusions: Pre-operative MGC imaging in sentinel lymph node biopsy can provide comparable information for operative planning, compared to standard FGC imaging.
Gene Expression Profiling of Acute Myeloid Leukemia Shows Therapeutically Meaningful Patterns of Association with Ara-CTP Pharmacokinetics and Pharmacodynamics
Authors: Jatinder K. Lamba, Kristine Crews, Stanley Pounds, Xueyuan Cao, Sharyn D. Baker, Varsha Gandhi, William Plunkett, James R. Downing, Jeffrey Rubnitz, Raul C. Ribeiro
Journal: Blood (2008)
RETRACTED ARTICLE: m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to induce NSCLC drug resistance and metastasis
Authors: Dan Jin, Jiwei Guo, Yan Wu, Jing Du, Lijuan Yang, Xiaohong Wang, Weihua Di, Baoguang Hu, Jiajia An, Lingqun Kong, Lei Pan, Guoming Su
Journal: Journal of Hematology & Oncology (2019)

Abstract Background METTL3 is an RNA methyltransferase that mediates m 6 A modification and is implicated in mRNA biogenesis, decay, and translation. However, the biomechanism through which METTL3 regulates MALAT1-miR-1914-3p-YAP axis activity to induce NSCLC drug resistance and metastasis is not very clear. Methods The expression of mRNA was analyzed by qPCR assays. Protein levels were analyzed by western blotting and immunofluorescent staining. Cellular proliferation was detected by CCK8 assays. Cell migration and invasion were analyzed by wound healing and transwell assays, respectively. Promoter activities and gene transcription were analyzed by luciferase reporter assays. Finally, m 6 A modification was analyzed by MeRIP. Results METTL3 increased the m 6 A modification of YAP . METTL3, YTHDF3, YTHDF1, and eIF3b directly promoted YAP translation through an interaction with the translation initiation machinery. Moreover, the RNA level of MALAT1 was increased due to a higher level of m 6 A modification mediated by METTL3. Meanwhile, the stability of MALAT1 was increased by METTL3/YTHDF3 complex. Additionally, MALAT1 functions as a competing endogenous RNA that sponges miR-1914-3p to promote the invasion and metastasis of NSCLC via YAP. Furthermore, the reduction of YAP m 6 A modification by METTL3 knockdown inhibits tumor growth and enhances sensitivity to DDP in vivo. Conclusion Results indicated that the m 6 A mRNA methylation initiated by METTL3 promotes YAP mRNA translation via recruiting YTHDF1/3 and eIF3b to the translation initiation complex and increases YAP mRNA stability through regulating the MALAT1-miR-1914-3p-YAP axis. The increased YAP expression and activity induce NSCLC drug resistance and metastasis.
Identification of Therapeutic Vulnerabilities in Small-cell Neuroendocrine Prostate Cancer
Authors: Alexandra N. Corella, Ma Victoria Andrea Cabiliza Ordonio, Ilsa Coleman, Jared M. Lucas, Arja Kaipainen, Holly M. Nguyen, Daniel Sondheim, Lisha G. Brown, Lawrence D. True, John K. Lee, David MacPherson, Paul Nghiem, Roman Gulati, Colm Morrissey, Eva Corey, Peter S. Nelson
Journal: Clinical Cancer Research (2019)

Small-cell neuroendocrine prostate cancer (SCNPC) exhibits an aggressive clinical course and incidence rates seem to be increasing following resistance to potent androgen receptor (AR) antagonists. Currently, treatment options are limited and few model systems are available to identify new approaches for treatment. We sought to evaluate commonalities between SCNPC and other aggressive neuroendocrine carcinomas to identify therapeutic targets.
Rilpivirine-associated aggregation-induced emission enables cell-based nanoparticle tracking
Authors: Insiya Z. Mukadam, Jatin Machhi, Jonathan Herskovitz, Mahmudul Hasan, Maxim D. Oleynikov, Wilson R. Blomberg, Denis Svechkarev, Aaron M. Mohs, You Zhou, Prasanta Dash, JoEllyn McMillan, Santhi Gorantla, Jered Garrison, Howard E. Gendelman, Bhavesh D. Kevadiya
Journal: Biomaterials (2019)
Ovalbumin in breastmilk is associated with a decreased risk of IgE‐mediated egg allergy in children
Authors: Valerie Verhasselt, Jon Genuneit, Jessica R. Metcalfe, Meri K. Tulic, Akila Rekima, Debra J. Palmer, Susan L. Prescott
Journal: Allergy (2019)

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Initial Results of a Randomized, Prospective Trial of Prophylaxis To Prevent Joint Disease in Young Children with Factor VIII (FVIII) Deficiency.
Authors: Marilyn J. Manco-Johnson, Thomas C. Abshire, Deborah Brown, George R. Buchanan, Alan R. Cohen, Donna DiMichele, W. Keith Hoots, Cindy A. Leissinger, Kevin McRedmond, Diane J. Nugent, Amy D. Shapiro, Gregory A. Thomas, Leonard A. Valentino, Brenda Riske
Journal: Blood (2005)
Integrated Epigenetic Profiling Identifies EZH2 As a Therapeutic Target to Re-Establish Immune Recognition of Leukemia Relapses with Loss of HLA Class II Expression
Authors: Valentina Gambacorta, Daniela Gnani, Laura Zito, Stefano Beretta, Lucia Zanotti, Oliveira Giacomo, Davide Cittaro, Ivan Merelli, Fabio Ciceri, Raffaella Di Micco, Luca Vago
Journal: Blood (2019)
Integrative Omics Approach to Identifying Genes Associated With Atrial Fibrillation
Authors: Biqi Wang, Kathryn L. Lunetta, Josée Dupuis, Steven A. Lubitz, Ludovic Trinquart, Lixia Yao, Patrick T. Ellinor, Emelia J. Benjamin, Honghuang Lin
Journal: Circulation Research (2019)

Rationale: GWAS (Genome-Wide Association Studies) have identified hundreds of genetic loci associated with atrial fibrillation (AF). However, these loci explain only a small proportion of AF heritability. Objective: To develop an approach to identify additional AF-related genes by integrating multiple omics data. Methods and Results: Three types of omics data were integrated: (1) summary statistics from the AFGen 2017 GWAS; (2) a whole blood EWAS (Epigenome-Wide Association Study) of AF; and (3) a whole blood TWAS (Transcriptome-Wide Association Study) of AF. The variant-level GWAS results were collapsed into gene-level associations using fast set-based association analysis. The CpG-level EWAS results were also collapsed into gene-level associations by an adapted SNP-set Kernel Association Test approach. Both GWAS and EWAS gene-based associations were then meta-analyzed with TWAS using a fixed-effects model weighted by the sample size of each data set. A tissue-specific network was subsequently constructed using the NetWAS (Network-Wide Association Study). The identified genes were then compared with the AFGen 2018 GWAS that contained more than triple the number of AF cases compared with AFGen 2017 GWAS. We observed that the multiomics approach identified many more relevant AF-related genes than using AFGen 2018 GWAS alone (1931 versus 206 genes). Many of these genes are involved in the development and regulation of heart- and muscle-related biological processes. Moreover, the gene set identified by multiomics approach explained much more AF variance than those identified by GWAS alone (10.4% versus 3.5%). Conclusions: We developed a strategy to integrate multiple omics data to identify AF-related genes. Our integrative approach may be useful to improve the power of traditional GWAS, which might be particularly useful for rare traits and diseases with limited sample size.
Inhibition of MDR1 Overcomes Resistance to Brentuximab Vedotin in Hodgkin Lymphoma
Authors: Robert Chen, Alex F. Herrera, Jessie Hou, Lu Chen, Jun Wu, Yuming Guo, Timothy W. Synold, Vu N. Ngo, Sandrine Puverel, Matthew Mei, Leslie Popplewell, Shuhua Yi, Joo Y. Song, Shu Tao, Xiwei Wu, Wing C. Chan, Stephen J. Forman, Larry W. Kwak, Steven T. Rosen, Edward M. Newman
Journal: Clinical Cancer Research (2019)

Abstract Purpose: In classical Hodgkin lymphoma, the malignant Reed–Sternberg cells express the cell surface marker CD30. Brentuximab vedotin is an antibody–drug conjugate (ADC) that selectively delivers a potent cytotoxic agent, monomethyl auristatin E (MMAE), to CD30-positive cells. Although brentuximab vedotin elicits a high response rate (75%) in relapsed/refractory Hodgkin lymphoma, most patients who respond to brentuximab vedotin eventually develop resistance. Patients and Methods: We developed two brentuximab vedotin–resistant Hodgkin lymphoma cell line models using a pulsatile approach and observed that resistance to brentuximab vedotin is associated with an upregulation of multidrug resistance-1 (MDR1). We then conducted a phase I trial combining brentuximab vedotin and cyclosporine A (CsA) in patients with relapsed/refractory Hodgkin lymphoma. Results: Here, we show that competitive inhibition of MDR1 restored sensitivity to brentuximab vedotin in our brentuximab vedotin–resistant cell lines by increasing intracellular MMAE levels, and potentiated brentuximab vedotin activity in brentuximab vedotin–resistant Hodgkin lymphoma tumors in a human xenograft mouse model. In our phase I trial, the combination of brentuximab vedotin and CsA was tolerable and produced an overall and complete response rate of 75% and 42% in a population of patients who were nearly all refractory to brentuximab vedotin. Conclusions: This study may provide a new therapeutic strategy to combat brentuximab vedotin resistance in Hodgkin lymphoma. This is the first study reporting an effect of multidrug resistance modulation on the therapeutic activity of an ADC in humans. The expansion phase of the trial is ongoing and enrolling patients who are refractory to brentuximab vedotin to confirm clinical activity in this population with unmet need.
PAK4 inhibition improves PD-1 blockade immunotherapy
Authors: Gabriel Abril-Rodriguez, Davis Y. Torrejon, Wei Liu, Jesse M. Zaretsky, Theodore S. Nowicki, Jennifer Tsoi, Cristina Puig-Saus, Ignacio Baselga-Carretero, Egmidio Medina, Michael J. Quist, Alejandro J. Garcia, William Senapedis, Erkan Baloglu, Anusha Kalbasi, Gardenia Cheung-Lau, Beata Berent-Maoz, Begoña Comin-Anduix, Siwen Hu-Lieskovan, Cun-Yu Wang, Catherine S. Grasso, Antoni Ribas
Journal: Nature Cancer (2019)
Carbon Dots as Potent Antimicrobial Agents
Authors: Xiuli Dong, Weixiong Liang, Mohammed J. Meziani, Ya-Ping Sun, Liju Yang
Journal: Theranostics (2019)

Carbon dots (CDots) have emerged to represent a highly promising new platform for visible/natural light-activated microbicidal agents.In this article, the syntheses, structures, and properties of CDots are highlighted, representative studies on their activities against bacteria, fungi, and viruses reviewed, and the related mechanistic insights discussed.Also highlighted and discussed are the excellent opportunities for potentially extremely broad applications of this new platform, including theranostics uses.
Effect of Venous Thrombotic Events on Overall Survival in Multiple Myeloma: Analysis of Thrombotic Events Occurring in E4A03A Randomized Trial of Lenalidomide Plus High-Dose Dexamethasone (RD) Versus Lenalidomide Plus Low-Dose Dexamethasone (Rd) in Newly Diagnosed Multiple Myeloma, a Trial Coordinated by the Eastern Cooperative Oncology Group (ECOG).
Authors: Susanna Jacobus, Shaji Kumar, Natalie Scott Callander, Rafat Abonour, Rafael Fonseca, David Siegel, Philip Greipp, S. Vincent Rajkumar
Journal: Blood (2008)
Abstract 14831: Using Machine Learning to Identify Sub-Phenotypes of Cardiovascular Disease for Genetic Association
Authors: Juan Zhao, Yun Zhang, Qiping Feng, Wei-qi Wei
Journal: Circulation (2019)

Introduction: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. CVD involves various organs e.g. heart, lung, kidney, muscle, and blood, regulated by different...
Disease Progression and Outcomes of Pregnancies in Women With Eosinophilic Esophagitis
Authors: Philipp Schreiner, Silas Meissgeier, Ekaterina Safroneeva, Thomas Greuter, Gerhard Rogler, Alain Schoepfer, Dagmar Simon, Hans-Uwe Simon, Luc Biedermann, Alex Straumann
Journal: Clinical Gastroenterology and Hepatology (2019)
NON-UNIFORM BLOOD FLOW THROUGH THE ISCHEMIC MYOCARDIUM INDUCED BY STELLATE GANGLION STIMULATION
Authors: Yasumi Uchida, Hideo Ueda
Journal: Circulation (1972)

The effect of electrical stimulation of the stellate ganglion on the blood flow through the ischemic myocardium was examined in anesthetized open-chest dogs. The flow was continuously monitored by heated cross-thermocouples. The anterior descending branch of the left coronary artery was constricted in order to produce various ischemic states in the anterior wall of the left ventricle. Following stimulation, the flow through the outer half of the wall was increased before constriction, was slightly reduced during mild constriction, was markedly reduced during moderate constriction and was slightly reduced or increased during severe constriction. The flow through the inner half was not infrequently reduced before constriction, was slightly reduced or increas-ed during mild constriction and was markedly increased during moderate or severe constriction. These flow changes had a relation to the pressure gradients between the constricted and non-constricted branch. The flow through the zones adjacent to the constricted area was augmented by stimulation. Pretreatment with propranolol eliminated these flow changes. These results suggest the regional difference of sympathetic regulation of the myocardial blood flow and the dependence of its modality on the severity of ischemia. It is supposed that stimulation-induced reduction in the flow through the moderately ischemic myocardium was due to 'coronary steal' and that its occurrance is dependent on the severity of constriction of the coronary artery.