tbuckley/cabot-search huggingface dataset:
Re-evaluating the potential impact and cost-effectiveness of rotavirus vaccination in 73 Gavi countries: a modelling study
Authors: Frédéric Debellut, Andrew Clark, Clint Pecenka, Jacqueline Tate, Ranju Baral, Colin Sanderson, Umesh Parashar, Laura Kallen, Deborah Atherly
Journal: The Lancet Global Health (2019)

Previous studies have found rotavirus vaccination to be highly cost-effective in low-income countries. However, updated evidence is now available for several inputs (ie, rotavirus disease mortality rates, rotavirus age distributions, vaccine timeliness, and vaccine efficacy by duration of follow-up), new rotavirus vaccines have entered the market, vaccine prices have decreased, and cost-effectiveness thresholds have been re-examined. We aimed to provide updated cost-effectiveness estimates to inform national decisions about the new introduction and current use of rotavirus vaccines in Gavi countries.
UCBT Using Myeloablative Conditioning Regimen without ATG Has Similar Survival but Better Life Quality Compared with Upbsct for Adults with Primary Acute Leukemia-a Multicenter Study in China
Authors: Juan Tong, Li Xuan, Yanling Sun, Changcheng Zheng, Huilan Liu, Xiaoyu Zhu, Baolin Tang, Qifa Liu, Dongjun Lin, Zimin Sun
Journal: Blood (2016)
A Portrait of the Physician as a Young Man
Authors: Ian R. Ross
Journal: Annals of Internal Medicine (2019)

On Being a Doctor19 November 2019A Portrait of the Physician as a Young ManIan R. Ross, MDIan R. Ross, MDPenn State College of Medicine, Hershey, Pennsylvania (I.R.R.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M19-0892 Audio Reading - “A Portrait of the Physician as a Young Man” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “A Portrait of the Physician as a Young Man” by Ian R. Ross, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The 8-year-old boy was going to be an artist. As soon as the clanging of the school bell signaled the end of class, his fingers swapped the yellow number 2 graphite for the worn edges of compressed charcoal. He relished breathing in the aroma of an unmarked page of his sketchbook as his mind planned the first stroke. Ordinary objects would become something transformed through the movements of his hand. A dilapidated house on Riverside Road became a sinister mansion full of witches and goblins. A basset hound became a portrait of a pet in the throes of death, her ... Author, Article, and Disclosure InformationAffiliations: Penn State College of Medicine, Hershey, Pennsylvania (I.R.R.)Corresponding Author: Ian R. Ross, MD, Penn State Hershey Internal Medicine, 500 University Drive, Hershey, PA 17033; e-mail, ir[email protected]psu.edu. PreviousarticleNextarticle Advertisement Audio Reading - “A Portrait of the Physician as a Young Man” Audio. Michael A. Lacombe, MD, Annals Associate Editor, reads “A Portrait of the Physician as a Young Man” by Ian R. Ross, MD Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics Cited byUniversal Access to Cognitive Behavioral Therapy and Antidepressants Is Necessary for All Patients With Major Depressive DisorderMark Sinyor, MSc, MD 19 November 2019Volume 171, Issue 10Page: 769KeywordsChartsComputersHeart failureLiverLungsProblem solvingShouldersStrokeThoraxWeight loss ePublished: 19 November 2019 Issue Published: 19 November 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Systematic Characterization of Genes Representing Preferential Molecular Vulnerabilities for Myeloma Cells Compared to Other Neoplasias - Implications for the Biology and Therapeutic Targeting of Myeloma
Authors: Ricardo De Matos Simoes, Ryosuke Shirasaki, Sondra L. Downey-Kopyscinski, Geoffrey Matthews, Hu Yiguo, Michal Sheffer, Eugen Dhimolea, Olga Dashevsky, Sara Gandolfi, Joshua Dempster, Robin M. Meyers, Jordan Bryan, James M. McFarland, Johanna Brueggenthies, Huihui Tang, Megan Bariteau, Minasri Borah, Quinlan L Sievers, Benjamin Ebert, Brian Glassner, Christopher J. Ott, Nicholas P Kwiatkowski, John G Doench, Daniel Auclair, Joan Levy, Lawrence H. Boise, Jonathan J Keats, Jonathan D. Licht, Richard Groen, Nathanael Gray, Aedin Culhane, William C. Hahn, Francisca Vazquez, Aviad Tsherniak, Constantine S. Mitsiades
Journal: Blood (2019)
Evaluating nanopore sequencing data processing pipelines for structural variation identification
Authors: Anbo Zhou, Timothy Lin, Jinchuan Xing
Journal: Genome biology (2019)

Abstract Background Structural variations (SVs) account for about 1% of the differences among human genomes and play a significant role in phenotypic variation and disease susceptibility. The emerging nanopore sequencing technology can generate long sequence reads and can potentially provide accurate SV identification. However, the tools for aligning long-read data and detecting SVs have not been thoroughly evaluated. Results Using four nanopore datasets, including both empirical and simulated reads, we evaluate four alignment tools and three SV detection tools. We also evaluate the impact of sequencing depth on SV detection. Finally, we develop a machine learning approach to integrate call sets from multiple pipelines. Overall SV callers’ performance varies depending on the SV types. For an initial data assessment, we recommend using aligner minimap2 in combination with SV caller Sniffles because of their speed and relatively balanced performance. For detailed analysis, we recommend incorporating information from multiple call sets to improve the SV call performance. Conclusions We present a workflow for evaluating aligners and SV callers for nanopore sequencing data and approaches for integrating multiple call sets. Our results indicate that additional optimizations are needed to improve SV detection accuracy and sensitivity, and an integrated call set can provide enhanced performance. The nanopore technology is improving, and the sequencing community is likely to grow accordingly. In turn, better benchmark call sets will be available to more accurately assess the performance of available tools and facilitate further tool development.
PATH-14. IMMUNOHISTOCHEMICAL ANALYSIS OF TUMOR ASSOCIATED MACROPHAGE INDUCED AFTER CARMUSTINE WAFER IMPLANTATION IN HUMAN GLIOBLASTOMA
Authors: Ichiyo Shibahara, Kazuhiro Miyasaka, Sumito Sato, Madoka Inukai, Yoshie Yasui, Takuichiro Hide, Toshihiro Kumabe
Journal: Neuro-Oncology (2019)

Abstract The carmustine (BCNU) wafer, a biodegradable polymer, currently is the only drug that is able to be placed at the surgical site to treat malignant tumors. Biomaterials to treat cancers hold therapeutic potential; however, how they behave inside the tumor microenvironment requires further study. We previously investigated the tumor microenvironment after BCNU wafer implantation, and found that CD68-positive macrophage was significantly introduced around the wafer (Shibahara et al. J Neurooncol 2018). Recent studies demonstrated the importance of tumor-associated macrophage (TAM). However, we could not clarify whether the increased macrophage around the wafer was pro-tumor or anti-tumor phenotype. In the present study, we immunohistochemically examined expressions of CD68, IBA1, CD163, TMEM119, BIN1, CD31, and VEGF to investigate TAM after the wafer implantation. Quantitative evaluation revealed that CD68+ cells were significantly increased (P = 0.0009), whereas TMEM119+ cells were significantly decreased (P = 0.0081) after wafer implantation compared to tissue from cases without wafer implantation. CD163, a known marker of poor prognosis in glioblastoma, did not differ with and without wafer implantation. Among factor analyzed, BCNU wafer did not induce protumor TAM, but reduced microglial marker, TMEM 119. In addition to the aspect of chemotherapy, BCNU wafer may have potential to modify the tumor microenvironment such as TAM.
QOLP-16. DISTRESSED (D TYPE) PERSONALITY, PREOPERATIVE PSYCHOLOGICAL DISTRESS, COGNITIVE FUNCTIONING, QUALITY OF LIFE, AND TREATMENT OUTCOMES OF GLIOMA PATIENTS: PROSPECTIVE STUDY
Authors: Aiste Pranckeviciene, Ausra Saudargiene, Vytenis Deltuva, Arimantas Tamasauskas, Adomas Bunevicius
Journal: Neuro-Oncology (2019)

Abstract BACKGROUND This study aimed to evaluate impact of distressed (D type) personality on preoperative psychological distress, cognitive functioning and quality of life (QoL) as well as short-term and long-term treatment outcomes of glioma patients. METHOD One-hundred and seventy patients (93 men, mean age=51.1±14.5 years) participated in the study. Fifty-four (31.8%) patients were diagnosed with low grade (WHO grade I-II), and 116 (68.2%) with high grade (WHO grade III-IV) tumors. Psychological assessment was performed 2–3 days before surgery using a set of self-report questionnaires (NCCN Distress thermometer, EORTC-QLQ-C30, EORTCQLQ-BN20, HADS, DS-14) and a short battery of neuropsychological tests. Functional status at the discharge was assessed using the GOS. Follow-up period was 40 months. RESULTS Thirty-nine (22.9%) of patients met criteria for D type personality. D-type patients relative to non D-type patients reported significantly worse QoL, higher number tumor related symptoms, greater depression and anxiety symptoms, and demonstrated slowing of psychomotor speed in neuropsychological tests. However, no personality related differences were observed in level of functioning at time of discharge as well as long-term patients’ survival. Path analysis using SEM revealed non-direct impact of D-type personality traits on patients QoL (Chi-square value=16.73, df=13, p=0.212). The model indicated statistically significant indirect effects of D-type Negative Affectivity on QoL (IPC -0.285, 95% CI [-0.386; -0.178], p=0.003) and tumor related symptoms (IPC 0.196, 95% CI [0.117; 0.296], p=0.002) mediated via depression and anxiety. Social Inhibition was also indirectly associated with QoL (IPC -0.047, 95% CI [-0.120; -0.002], p=0.035) and symptoms (IPC 0.033, 95% CI [0.002; 0.097], p=0.032) through depression and anxiety. CONCLUSION D-type personality contributes to impairment of QoL and higher number of reported symptoms in glioma patients via increased susceptibility for depression and anxiety.
Breaking the Glass Ceiling of Age in Transplant in Multiple Myeloma
Authors: Pashna N. Munshi, Parameswaran Hari, David H. Vesole, Artur Jurczyszyn, Jan Zaucha, Omar Davila, Shaji K. Kumar, Nina D. Shah, Muzaffar H. Qazilbash, Anita D'Souza
Journal: Blood (2019)
IMMU-21. SEQUENTIAL TWO-RECEPTOR PRIMING CAR SYSTEM TO OVERCOME HETEROGENEOUS ANTIGEN EXPRESSION
Authors: Payal Watchmaker, Joseph Choe, Diego Carrera, Ryan Gilbert, Wei Yu, Kira Downey, Kole Roybal, Wendell Lim, Hideho Okada
Journal: Neuro-Oncology (2019)

Abstract Heterogeneous expression of target antigens allows tumor escape from chimeric antigen receptor-transduced T-cell (CART) therapy targeting a single antigen. While epidermal growth factor receptor (EGFR)vIII represents a glioblastoma (GBM)-specific antigen, its expression is heterogeneous within the tumor. On the other hand, most other antigens expressed more uniformly in GBMs are non-mutated, glioma-associated antigens (GAAs), such as EphA2. Although these GAAs are not expressed in the normal brain, they are expressed at low levels in other normal organs. As a way to safely target GAAs in the tumor without attacking normal cells expressing the same GAAs outside of the brain, we adapted a novel synthetic Notch (synNotch) receptor system, and established a “prime and kill” sequential two-receptor CAR circuit: the first is a transcriptional CAR against EGFRvIII, and the second is a CAR against a GAA (e.g. EphA2). When the first CAR binds to EGFRvIII, it induces the expression of the second CAR against GAA. While the first CAR does not trigger the cytotoxic function itself, the second CAR mediates the cytotoxicity upon recognition of the target GAA. We validated this system in vitro using the mixture of U87 GBM cells and those transduced with EGFRvIII. SynNotch CART effectively lysed both EGFRvIII+ and EGFRvIII-negative U87 cells when they are mixed, but never lysed EGFRvIII-negative cells in the absence of EGFRvIII+ cells. SynNotch CART cells exhibited precise local effect in vivo, sparing EGFRvIII-negative subcutaneous tumor while efficiently clearing intracranial EGFRvIII heterogeneous tumor. In the orthotopic GBM6 model, which is a patient-derived xenograft with heterogeneous expression of EGFRvIII, intravenous infusion of synNotch CART resulted in long-term (over 50 days) survival and eradication of the heterogeneous tumor in 6 of 6 mice, while the conventional anti-EGFRvIII CART failed to do so. These data provide a strong basis for developing synNotch CART therapy for GBM.
Comparative Studies on the Interaction of Unfractionated Heparin and Sulodexide with Functional Anti-Heparin Platelet Factor 4 Antibodies
Authors: Ambar Farooqui, Debra Hoppensteadt, Omer Iqbal, Cassie Bacher, Jeanine Walenga, Ahmed Kouta, Walter Jeske, Bruce Lewis, Jawed Fareed
Journal: Blood (2019)
Novelties in imaging in pulmonary fibrosis and nodules. A narrative review
Authors: S. Ley, J. Ley-Zaporozhan
Journal: Pulmonology (2019)

In recent months two major fields of interest in pulmonary imaging have stood out: pulmonary fibrosis and pulmonary nodules. New guidelines have been released to define pulmonary fibrosis and subsequent studies have proved the value of these changes. In addition, new recommendations for classification of pulmonary nodules have been released. Radiological images are of major interest for automated and standardized analysis and so in both cases software tools using artificial intelligence were developed for visualization and quantification of the disease. These tools have been validated by human readers and demonstrated their capabilities. This review summarizes the new recommendations for classification of pulmonary fibrosis and nodules and reviews the capabilities of radiomics within these two entities.
Activating Mutations Are Potent Pro-Leukemic Mediators in Murine MLL-MLLT3 Leukemia That Cause Distinct Transcriptional Profiles
Authors: Axel Hyrenius-Wittsten, Helena Sturesson, Michael P. Walsh, Jenny Hansson, Julhash U. Kazi, Mattias Pilheden, Stephanie Nance, Pankaj Gupta, Guangchun Song, Jinghui Zhang, Jing Ma, Tanja A. Gruber, James R. Downing, Anna K. Andersson
Journal: Blood (2016)
Steep Neutrophil Recovery Following Unrelated Bone Marrow Transplantation Is a Major Risk Factor for the Development of Acute Graft-Vs-Host Disease
Authors: Takashi Nagayama, Shin-ichiro Fujiwara, Hirotomo Nakashima, Shinichiro Kawaguchi, Shoko Ito, Kiyomi Mashima, Kento Umino, Daisuke Minakata, Hirofumi Nakano, Ryoko Yamasaki, Kaoru Morita, Chihiro Yamamoto, Masahiro Ashizawa, Kaoru Hatano, Kazuya Sato, Iekuni Oh, Ken Ohmine, Kazuo Muroi, Yoshinobu Kanda
Journal: Blood (2019)
Mental imagery: In search of my theory
Authors: Edward de Haan, André Aleman
Journal: Behavioral and Brain Sciences (2002)

We argue that the field has moved forward from the old debate about “analogical” versus “symbolic” processing. First, it is questionable that there is a strong a priori argument for assuming a common processing mode. Second, we explore the possibility that imagery is not a unitary mental function. Finally, we discuss the empirical basis of the involvement of primary areas.
Shortened TDP43 isoforms upregulated by neuronal hyperactivity drive TDP43 pathology in ALS
Authors: Kaitlin Weskamp, Elizabeth M. Tank, Roberto Miguez, Jonathon P. McBride, Nicolás B. Gómez, Matthew White, Ziqiang Lin, Carmen Moreno Gonzalez, Andrea Serio, Jemeen Sreedharan, Sami J. Barmada
Journal: Journal of Clinical Investigation (2019)

Cortical hyperexcitability and mislocalization of the RNA-binding protein TDP43 are highly conserved features in amyotrophic lateral sclerosis (ALS). Nevertheless, the relationship between these phenomena remains poorly defined. Here, we showed that hyperexcitability recapitulates TDP43 pathology by upregulating shortened TDP43 (sTDP43) splice isoforms. These truncated isoforms accumulated in the cytoplasm and formed insoluble inclusions that sequestered full-length TDP43 via preserved N-terminal interactions. Consistent with these findings, sTDP43 overexpression was toxic to mammalian neurons, suggesting neurodegeneration arising from complementary gain- and loss-of-function mechanisms. In humans and mice, sTDP43 transcripts were enriched in vulnerable motor neurons, and we observed a striking accumulation of sTDP43 within neurons and glia of ALS patients. Collectively, these studies uncover a pathogenic role for alternative TDP43 isoforms in ALS, and implicate sTDP43 as a key contributor to the susceptibility of motor neurons in this disorder.
The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes
Authors: Mireia Ramos-Rodríguez, Helena Raurell-Vila, Maikel L. Colli, Maria Inês Alvelos, Marc Subirana-Granés, Jonàs Juan-Mateu, Richard Norris, Jean-Valery Turatsinze, Ernesto S. Nakayasu, Bobbie-Jo M. Webb-Robertson, Jamie R. J. Inshaw, Piero Marchetti, Lorenzo Piemonti, Manel Esteller, John A. Todd, Thomas O. Metz, Décio L. Eizirik, Lorenzo Pasquali
Journal: Nature Genetics (2019)
High-Dose Cytarabine Is Indispensable for the Survival of Children with Myeloid Leukemia of Down Syndrome Despite Negative Minimal Residual Disease Post-Induction
Authors: Johann K. Hitzler, Jason Berman, Robert B. Gerbing, Amy Beckman, Betsy A Hirsch, Susana C. Raimondi, Todd E Druley, Michael R. Loken, Lisa Eidenschink Brodersen, Karen Chisholm, Shelton A. Viola, Jeffrey W. Taub, Alan S Gamis, Todd A. Alonzo, E. Anders Kolb
Journal: Blood (2019)
Historical Practice of Separating Twins at Birth
Authors: Adam M. Kelmenson, Ilene Wilets
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Role of hypoxia in cancer therapy by regulating the tumor microenvironment
Authors: Xinming Jing, Fengming Yang, Chuchu Shao, Ke Wei, Mengyan Xie, Hua Shen, Yongqian Shu
Journal: Molecular Cancer (2019)

Abstract Aim Clinical resistance is a complex phenomenon in major human cancers involving multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular expression program and lead to therapy resistance. The present study aimed to summarize the role of hypoxia in cancer therapy by regulating the tumor microenvironment (TME) and to highlight the potential of hypoxia-targeted therapy. Methods Relevant published studies were retrieved from PubMed, Web of Science, and Embase using keywords such as hypoxia, cancer therapy, resistance, TME, cancer, apoptosis, DNA damage, autophagy, p53, and other similar terms. Results Recent studies have shown that hypoxia is associated with poor prognosis in patients by regulating the TME. It confers resistance to conventional therapies through a number of signaling pathways in apoptosis, autophagy, DNA damage, mitochondrial activity, p53, and drug efflux. Conclusion Hypoxia targeting might be relevant to overcome hypoxia-associated resistance in cancer treatment.
Acute Myeloid Leukemia with Myelodisplasia-Related Changes (AML-MRC) Defined Only By Morphological Findings May Not Represent a Poor Prognosis AML
Authors: Ana Pérez, Olga Salamero, Helena Pomares, Maria Julia Montoro, Montserrat Arnan Sangerman, Laura Gallur, María Laura Fox, Elisa Roldan, Antonieta Molero, Guillermo Ortí, Mayda Navarrete, Esther Alonso, Bárbara Tazón, M Moraima Jimenez, Margarita Ortega, Adoración Blanco, Gael Roue, Pere Barba, Silvia Saumell, David Valcárcel, Francesc Bosch
Journal: Blood (2019)
Acute Myeloid Leukemia Export Mitochondria in Extracellular Vesicles Which Induces Pro-Tumoral Changes in Bone Marrow Macrophages
Authors: Jamie A Moore, Jayna J Mistry, Rebecca H Horton, Charlotte Hellmich, Adam Pattinson, Adam Morfakis, Yu Sun, Matthew Lawes, Christopher J Morris, Anna Haestier, Kristian M Bowles, Stuart A Rushworth
Journal: Blood (2019)
Child-resistant containers.
Authors: D H Reid
Journal: BMJ (1970)

Nasal Cancer in the Shoe Industry SIR,-In our article on "Nasal Cancer in the Northamptonshire Boot and Shoe Industry" (14 February, p. 385) we were unable to give estimates of incidence within the industry because we lacked comprehensive information on the numbers of men employed in the different departments.We have since received from the British Foot- wear Manufacturers' Federation national figures relating to 1949-61 inclusive giving the numbers of operatives in each sex employed in the various departments.The figures include the numbers of men and women employed in clicking, closing, pressing, lasting, finishing, and shoe room departments.In making the calculations in the Table the figures for 1949-61 have been averaged and the proportions applied to the Northamptonshire industry.If the cases of Adenocarcinoma Other Carcinomas All Carcinomas Department Population --
Incorporating Reduced-Dose Plerixafor to a Preemptive Mobilization Algorithm Increases Access to Autologous Transplantation in a Limited-Resource Setting
Authors: Andrés Gómez-De León, Dalila Marisol Alvarado Navarro, Cesar O Pezina Cantú, Perla R. Colunga Pedraza, David Gomez-Almaguer, Rosario Salazar Riojas, Olga Graciela Cantu Rodriguez, Luz del Carmen Tarín Arzaga, Jose Carlos Jaime, Cesar Homero Gutierrez-Aguirre
Journal: Blood (2019)