tbuckley/cabot-search huggingface dataset:
Axillary management after neoadjuvant chemotherapy in breast cancer: A survey by Brazilian Society of Mastology.
Authors: Antonio Luiz Frasson, Martina Lichtenfels, Heloisa Magda Resende, Fernanda Barbosa, Isabela Miranda, Alessandra Borba, ANA Beatriz Falcone
Journal: Journal of Clinical Oncology (2020)

e12609 Background: Several trials have been investigating the accuracy of sentinel lymph node biopsy (SLNB) in clinically node-positive breast cancer patients undergoing neoadjuvant chemotherapy (NAC). A survey of breast surgeons was performed to assess the current management of axilla after NAC in Brazilian clinical practice. Methods: Brazilian Society of Breast Surgeons members were invited by email to complete an anonymous online survey. From 2000 eligible members, 426 (21.3%) members responded the survey. Results were summarized as proportions based on the number of responses to each question. Results: The majority of responders, 43.4%, indicated performing routine axillary staging by physician exam, ultrasound and PAAF (if necessary) in patients who are to undergo neoadjuvant chemotherapy. Approximately 43% of responders perform SLNB instead of ALND in patients with N1 axillary involvement before neoadjuvant chemotherapy, however many breast surgeons also indicated SLNB for N2 (27.7%) and N3 (18.8%) patients. Axillary complete pathologic response (ypN0) is necessary to omit ALND for 42.8% of responders and 19.5% do not perform ALND in patients getting ypN1is+ (isolated tumoral cells). Considering the option with patients getting ypN1is+ (isolated tumoral cells) and ypN1mic (micrometastases), 24.5% reported not performing ALND after SLND. Fifty-eight participants, 13.8%, accepted only SLNB in patients getting ypN1is+ (isolated tumoral cells), ypN1mic (micrometastases) and ypN1. The molecular profiling of breast tumor is considered when choosing axillary management after neoadjuvant chemotherapy for 26.3% of responders and for 73.7% the molecular profiling is not influencing the decision. Conclusions: Our survey highlighted the trend toward de-escalation of axillary surgery in patients undergoing neoadjuvant treatment and a high heterogeneity in axillary management after chemotherapy in Brazilian practice.
HELLP综合征五例
Authors: 赵曰孝, 崔黎明, 刘立新, 潘因
Journal: BMJ (2004)

HELLP综合征是妊娠高血压综合征(妊高征)的一种特殊类型或严重并发症.主要临床表现为在妊高征基础上出现溶血、肝酶升高、血小板减少.发病率不高,但母婴死亡率较高,目前尚无统一的诊断标准和特殊有效的治疗方法.现将我们2000年10月～2002年4月间收治的5例妊高征合并HELLP综合征患者的临床资料及治疗情况报告如下。
An optimal care coordination model for Medicaid patients with lung cancer: Lessons learned from the beta testing phase of a multisite initiative in the United States.
Authors: Matthew Smeltzer, Leigh Boehmer, Amanda Kramar, Thomas Asfeldt, Nicholas Ryan Faris, Meredith Ray, Christopher S. Lathan, Raymond U. Osarogiagbon
Journal: Journal of Clinical Oncology (2020)

e14010 Background: Medicaid patients with lung cancer often have less favorable outcomes than non-Medicaid patients, which, given provision of care is typically comparable, may be due to socioeconomic disparities between these populations. In 2016, the Association of Community Cancer Centers (ACCC) embarked on a 3-year initiative to develop and test the Optimal Care Coordination Model (OCCM) to improve care coordination for Medicaid patients with lung cancer. A framework of 13 independent care delivery areas, spanning access to care to survivorship and supportive care, aids cancer programs in identifying barriers to access and use of their care, with a focus on Medicaid patients, and therefore enables optimal care coordination. Methods: Seven community-based healthcare systems in 6 U.S. states were selected as OCCM beta testing sites and then supported by the ACCC via site visits and biweekly calls. Sites self-assessed the quality of their care in selected OCCM areas to identify relevant quality improvement projects and improve understanding of needs specific to Medicaid patients. Results: Total patient enrollment across all sites was 926 (257 Medicaid; 669 non-Medicaid). Each site selected 1–2 priority OCCM areas, including patient access to care, prospective multidisciplinary case planning, or tobacco cessation, for projects. Enhanced collaboration, improved programming (e.g., patient navigation and formation of lung health leadership team), and organic programmatic changes due to the OCCM work were identified as successes. Site-specific challenges included inadequate staffing at project start and lack of centralized data collection and coordination. The importance of lung cancer–dedicated navigation, multidisciplinary conference use for treatment planning, and understanding needs specific to Medicaid patients were key transferable lessons. Examples of institutional support received by sites during the project included opportunities for staff training and leadership commitment from other hospital departments to assist with care delivery improvements. Use of the existing OCCM framework; increased staffing, particularly for lung cancer navigation; and expanded community outreach were identified in the sustainability plans. Conclusions: OCCM beta testing helped sites self-assess care delivery and identify areas for improvement. Ultimately, it was apparent that Medicaid patients need to be treated differently to obtain equity of outcomes with non-Medicaid patients.
社区用药依从性不佳老年高血压患者的干预效果分析
Authors: 顾竞春, 刘瑜婕
Journal: BMJ (2011)

高血压患者一经确诊大多需终身服药,不仅要选择有效的降压药物,更重要的是患者要有良好的用药依从性,这直接影响到治疗效果和预后.本研究旨在观察社区老年高血压用药依从性不佳患者进行综合干预后依从性及血压的改变。
产后出血的诊治及预防
Authors: 马玉燕, 高洁
Journal: BMJ (2011)

产后出血是产科常见的危急重症,是导致孕产妇死亡的主要原因.尽管产后出血的病因基本明确,但并不能完全预防产后出血,如不及时抢救危及生命,所以产科医生应熟练掌握产后出血的救治措施.如何降低产后出血的发病率及致死率,是全球产科医生共同探究的热点问题.下面就产后出血的病因、病情严重程度评估、治疗措施进行探讨。
Social support system for family caregivers of schizophrenic patients in the communities of Beijing
Authors: Lifen Chen, Xiaoqin Lu
Journal: BMJ (2019)

Objective
To develop the social support system for family caregivers of schizophrenic patients in community.


Methods
Based on the previous field investigation and the principle of comprehensiveness, feasibility, pertinence, suitability, generality and classification, the social support service item pool was established. Fifteen experts with intermediate or higher professional titles and working in the mental health fields were selected from government departments, specialized hospitals and community health service centers. The experts were consulted by Delphi and the results were analyzed.


Results
The average age of the consultation specialists was (40.7±8.0) years, and the duration of working in mental illness rehabilitation was (14.9±7.6) years. The positive coefficients of the two rounds of consultation were 100%, the authoritative coefficients of experts were 0.795, and the coordination coefficients of opinions were from 0.252 to 0.344, respectively. The 67 items of social support service for family caregivers of schizophrenic patients in Beijing were obtained after two rounds of expert consultation, but fewer of the services were for schizophrenic caregivers only.


Conclusion
The authority and society should take measures to establish a social support system for family caregivers of patients with schizophrenia, in order to reduce their family burden and improve the quality of rehabilitation for mental patients in the community.


Key words: 
Delphi technique; Schizophrenia; Caregiver; Social support
经鼻腔行食管支架置入术30例临床分析
Authors: 盖东和, 任闽山, 刘有生, 生英, 王伟
Journal: BMJ (2011)

食管覆膜支架置入术是晚期食管、贲门癌梗阻和(或)食管气管瘘最常用的姑息治疗方法.对于高龄患者,如病程晚期或合并症多已失去手术机会,为解决进食梗阻问题选择食管支架置入配合放射治疗,可有效提高生存质量、延长生命.对于气管食管瘘患者选择食管覆膜支架置入既可控制肺部感染,又能正常进食,生存质量显著高于空肠造瘘患者[1]. 关键词：假体植入
Research progress in post-stroke depression
Authors: 王书香, 武剑
Journal: BMJ (2011)

卒中后抑郁(post-stroke depression,PSD)是指脑卒中导致的有明显临床症状的一种继发性抑郁症,其临床表现主要是情绪低落、绝望自责、食欲减退、睡眠障碍、兴趣缺乏、焦虑及躯体化症状等[1].PSD是脑卒中常见并发症之一,严重影响卒中患者躯体和认知功能水平的恢复,增高卒中的致残率和死亡率.本综述旨在讨论PSD的临床相关问题,提高广大医务工作者对PSD的重视。
Patient characteristics and outcomes at the University of Kansas Cancer Urgent Care (CUC).
Authors: Rahul Atul Parikh, Stevani Thomas, Haylee Hento, Thu Janes, Gloria Solis, Joseph McGuirk, Jeff Wright, Terry Tsue, Weijing Sun
Journal: Journal of Clinical Oncology (2020)

e19154 Background: An increasing proportion of advanced cancer patients live longer and seek urgent or emergent care due to complex treatment regimens. Prolonged wait times and excessive cost of care are common deterrents for these patients to seek care in the Emergency Department (ED). Cancer Urgent Care (CUC) was established in February 2019 with the goal to provide timely and specialized care and improve outcomes for symptomatic cancer patients. Methods: CUC is staffed by two advanced nurse practitioners and two registered nurses and operates from 7am till 7 pm, Monday to Friday. Between 2019-2020, 471 patients were seen at the University of Kansas CUC. Visit information including diagnosis, duration of stay and outcome was retrospectively collected and analyzed using the REDcap database. Patient satisfaction and feedback surveys were conducted for each visit. Results: Most common causes for which patients sought care were dehydration 41.6%, nausea or vomiting 25.9%, pain 16.8%, diarrhea 9.8%, fever 9.6%, fatigue 8%, pneumonia 6.4% and sepsis 2.1%. Nearly 34% patients seen had underlying hematologic malignancy, other common disease sites included gastro-intestinal (26.8%), genito-urinary (14.6%) and breast cancer (13%). Average time to patient evaluation was 17 minutes and patients spend a mean of 3.2 hours in the CUC. Escalation of care (ED transfer) was required in 36 patients (7.6%), a majority of which (n = 28, 78%) required inpatient admission. An additional 58 patients (12.3%) required direct inpatient admission while a majority of patients (n = 385, 79.6%) were discharged home from the CUC. Overall patient satisfaction was very high, 68% patient noted that they would have sought care in ED if they were not seen in CUC while 30% patients would have waited for their next clinic appointment to discuss symptoms. Conclusions: Greater than 90% patients seen in CUC had a diagnosis being evaluated under Chemotherapy Measure (OP-35) by CMS. CUC provides a viable mechanism to provide specialized care to cancer patients resulting in improved patient satisfaction. Additional studies are ongoing to evaluate its impact on ED utilization and cost-effectiveness.
The first report of pediatric patients with solid tumors treated with venetoclax.
Authors: Kelly C. Goldsmith, Arnauld Verschuur, Daniel A. Morgenstern, Natasha van Eijkelenburg, Sara Michele Federico, Christopher Fraser, Christopher J. Forlenza, David Simon Ziegler, Nicolas U. Gerber, Seong Lin Khaw, Todd Michael Cooper, Christian Flotho, Betty A. Prine, Ahmed H. Salem, Kristina Unnebrink, Bo Tong, Tammy L. Palenski, Andrew E. Place
Journal: Journal of Clinical Oncology (2020)

10524 Background: Dependence on the prosurvival protein B-cell lymphoma 2 (BCL-2) occurs in certain pediatric solid tumors, resulting in tumorigenesis and resistance to therapies. Venetoclax (VEN), an orally administered BCL-2-selective inhibitor, has preclinical anticancer activity in human-derived neuroblastoma models. Reported here are preliminary results from pediatric patients (pts) with recurrent or refractory (R/R) solid tumors treated with VEN monotherapy or VEN with cyclophosphamide and topotecan (Cy-Topo). Methods: This phase 1 open-label, 2-part study (NCT03236857) enrolled pts &lt; 25 yr old with R/R malignancies; we report only on pts with solid tumors. Following a dose ramp-up, pts received 800 mg VEN (age/weight-adjusted adult equivalent) once daily for the first 8 wk; Cy-Topo was added optionally after wk 8. Dose-limiting toxicities (DLTs) were assessed during the first 21 days of VEN therapy or cycle 1 of VEN-Cy-Topo. Objectives included safety, toxicity, and preliminary efficacy. Results: As of Dec 17, 2019, 11 solid tumor pts were enrolled: neuroblastoma (n = 6), rhabdomyosarcoma (n = 2), Wilms’ tumor, Carney-Stratakis syndrome, and low-grade fibromyxoid sarcoma (n = 1 each). Median age was 11 yr (range 3–22); median time on study was 6.9 mo (range 1.2–17.8). All pts experienced ≥1 treatment-emergent adverse event (TEAE); vomiting (72%; all grades) was most common. Grade ≥3 TEAEs were reported in 82% of pts; febrile neutropenia (64%), decreased blood cell count, and neutropenia (36% each) were the most common. Seven pts received 800-mg monotherapy for 8 wk; 3 of these pts did not receive Cy-Topo after monotherapy. Of the 7 pts who received VEN-Cy-Topo, 3 pts received 400 mg VEN with Cy-Topo. DLTs of grade 4 neutropenia/thrombocytopenia with delayed count recovery occurred in 2 pts on 800 mg VEN-Cy-Topo, necessitating a dose de-escalation (to 400 mg VEN). Grade 4 neutropenia occurred in 2 pts on 400 mg VEN with Cy-Topo, leading to the addition of myeloid growth factor to the therapy regimen. The best response after 8 wk of VEN monotherapy was stable disease (SD). Six pts were evaluable for tumor response with VEN-Cy-Topo; 1 neuroblastoma pt had a complete response after 5 cycles of 400 mg VEN, 4 pts had SD (3 on 800 mg and 1 on 400 mg VEN) and 1 (800 mg VEN) had progressive disease as best response. Conclusions: Continuous dosing of VEN with Cy-Topo was not tolerated due to cytopenias in 4/7 pts with solid tumors. Discontinuous dosing of VEN with Cy-Topo is being explored. Clinical trial information: NCT03236857.
Research advance in pathogenesis and treatment of disseminated intravascular coagulation
Authors: 张渊, 祝墡珠, 陈倩
Journal: BMJ (2005)

弥漫性血管内凝血(DIC)是一种由多种基础病变所致的临床综合征,以全身凝血系统的激活、纤溶系统的紊乱、纤维蛋白沉积及多器官内微血栓形成等为特征,最终可出现广泛出血和多器官功能衰竭(MODS).感染、肿瘤、创伤、病理产科、严重肝病等是常见的病因,该病预后差,死亡率高,属临床重症.近年来,人们通过研究,对DIC的发病机制及诊治有了新的认识和更深入的了解,现综述如下。
Automated abstraction of real-world clinical outcome in lung cancer: A natural language processing and artificial intelligence approach from electronic health records.
Authors: Meng Ma, Arielle Redfern, Xiang Zhou, Dan Li, Ying Ru, Kyeryoung Lee, Christopher Gilman, Zongzhi Liu, Scott Jones, Yun Mai, Matthew Deitz, Yunrou Gong, Tommy Mullaney, Tony Prentice, Rong Chen, Eric Schadt, Xiaoyan Wang
Journal: Journal of Clinical Oncology (2020)

e14062 Background: Real world evidence generated from electronic health records (EHRs) is playing an increasing role in health care decisions. It has been recognized as an essential element to assess cancer outcomes in real-world settings. Automatically abstracting outcomes from notes is becoming a fundamental challenge in medical informatics. In this study, we aim to develop a system to automatically abstract outcomes (Progression, Response, Stable Disease) from notes in lung cancer. Methods: A lung cancer cohort (n = 5,003) was obtained from the Mount Sinai Data Warehouse. The progress, pathology and radiology notes of patients were used. We integrated various techniques of Natural Language Processing (NLP) and Artificial Intelligence (AI) and developed a system to automatically abstract outcomes. The corresponding images, biopsies and lines of treatments (LOTs) were abstracted as attributes of outcomes. This system includes four information models: 1. Customized NLP annotator model: preprocessor, section detector, sentence splitter, named entity recognition, relation detector; CRF and LSTM methods were applied to recognize entities and relations. 2. Clinical Outcome container model: biopsy evidence extractor, lines of treatment detector, image evidence extractor, clinical outcome event recognizer, date detector, and temporal reasoning; Domain-specific rules were crafted to automatically infer outcomes. 3. Document Summarizer; 4. Longitudinal Outcome Summarizer. Results: To evaluate the outcomes abstracted, we curated a subset (n = 792) from patient cohort for which LOTs were available. About 61% of the outcomes identified were supported by radiologic images (time window = ±14 days) or biopsy pathology results (time window = ±100 days). In 91% (720/792) of patients, Progression was abstracted within a time window of 90 days prior to first-line treatment. Also, 72% of the Progression events identified were accompanied by a downstream event (e.g., treatment change or death). We randomly selected 250 outcomes for manual curation, and 197 outcomes were assessed to be correct (precision = 79%). Moreover, our automated abstraction system improved human abstractor efficiency to curate outcomes, reducing curation time per patient by 90%. Conclusions: We have demonstrated the feasibility and effectiveness of NLP and AI approaches to abstract outcomes from lung cancer EHR data. It promises to automatically abstract outcomes and other clinical entities from notes across all cancers.
Gynaecologic cancer symptom awareness, concern and careseeking among US women: a multi-site qualitative study
Authors: 吴东
Journal: BMJ (2013)

背景
由于妇科恶性肿瘤有效的筛查手段有限，要实施妇科恶性肿瘤的早期检测有赖于妇女认识到出现症状的重要性并及时就医。


目的
调查妇女对妇科恶性肿瘤有关症状的关注情况、与症状关联的基础情况以及患者对所出现症状的实际或有可能的反应。


方法
在美国芝加哥、洛杉矶、迈阿密以及纽约入选40～60岁的女性，分为15个研究组。每位参与者将完成一张调查表，该表涉及妇科恶性肿瘤可能出现的各类症状，如何看待这些症状，是否会加以关注，推测可能的病因是什么以及如何处理，是否会因此就医等。


结果
整体而言，参与者对妇科方面的症状较其他方面的症状表现出更大的关注。但她们通常不会将此与恶性肿瘤联系起来。部分有症状的妇女要等相当长一段时间才就医或者根本不就医，最为常见的原因是她们认为症状是由良性的病变所引起。这些研究对象通常采用的策略是通过互联网获得相关知识及自我保健措施而不是去医疗机构就医。


结论
提高妇科恶性肿瘤有关症状的知晓率有助于疾病的早期筛查及改善生存率。特别重要的是，妇女应该知晓妇科恶性肿瘤引起的症状也许并非与生殖器官有关(如后背痛)，不正常的阴道出血应及时就医。
Clinicopathological characteristics of infectious granulomas: an analysis of 39 cases
Authors: You Hua, Xiujiao Xia, Hong Shen, Min Wang, Yali Gao, Qingwei Geng, Wenzhong Xiang
Journal: BMJ (2018)

Objective
To analyze the clinocopathological characteristics of infectious granulomas.


Methods
The clinical features, histopathological manifestations of 39 patients with infectious granulomas were analyzed retrospectively.


Results
Among 39 cases of infectious granulomas, there were 15 males and 24 females, and 17 cases of fungal granuloma and 22 cases of tuberculous granuloma. There was no statistically significant difference in gender and age between fungal granulomas and tuberculous granulomas. The mean course of tuberculous granuloma and tuberculous granuloma was (0.88±0.67) years and (5.54±3.49) years, respectively (t=4.51, P=0.00); there was no significant difference in mean age of onset in fungal granuloma patients and tuberculous granuloma patients [(54.6±19.6) vs. (47.6±18.1) years, P>0.05)]. There were 4 and 18 cases of fungal and tuberculous granulomatosis at the face, and 13 and 3 cases at the extremities (all P=0.00); the lesions occurred in the trunk in one case of tuberculous granuloma. The clinical manifestations of fungal and tuberculous granulomas as plaques/nodules were in 14 cases and 22 cases (P=0.08); as ulcers and pus exudates were in 10 and 2 cases, respectively (P=0.00). The histopathological features showed epidermal hyperplasia in 12 and 4 cases, infiltrative patterns in 4 and 21 cases, infiltration of neutrophils in 14 and 3 cases, infiltration of plasma cells in 15 and 5 cases, infiltration of eosinophils in 10 and 0 cases, necrosis in 1 and 10 cases in fungal granulomas and tuberculous granulomas, respectively (P= 0.00, 0.00, 0.00, 0.00, 0.00, 0.01).


Conclusion
Fungal granuloma and tuberculous granuloma are different in the lesion sites, clinical manifestations and histopathological features.


Key words: 
Granuloma, infectious; Granuloma, fungal; Granuloma, tuberculous; Pathological conditions, signs and symptoms
Abdominal visceral fat area and its relationship with insulin resistance in male patients with type 2 diabetes and normal body mass index
Authors: Huiling Wang, Qingying Tan, Xiujing Wang, Jing Wang, Yong Ruan, Yun Ruan, Jiaqi Yao
Journal: BMJ (2015)

Objective
To investigate abdominal visceral fat area and its relationship with insulin resistance in male patients with type 2 diabetes and normal body mass index (BMI).


Methods
Seven male patients with type 2 diabetes and normal BMI were divided into two groups according to the abdominal visceral fat area (VFA) measured by CT: visceral obesity group (VFA≥100 cm2) and non-visceral obesity group. Indicators of glucose and lipids metabolism were measured in two groups.


Results
Among 70 patients 50 (71%) had visceral obesity. In 59 patients who had normal BMI and normal waist circumference (≤90 cm), 41 presented visceral obesity (69%). Compared with non-visceral obesity group, the waist circumference, homeostasis model assessment of insulin resistance (HOMA-IR), triglyceride, and VFA were significantly higher in visceral obesity group [(86.4±5.6) vs. (81.2±4.8) cm, t=-2.980, P 0.05). Multiple linear regression analysis showed that after adjustment for age and body mass index, abdominal VFA was positively correlated with HOMA-IR (r=0.240, P<0.05).


Conclusion
Male type 2 diabetic patients have a high rate of visceral obesity even when their body mass index and waist circumference are normal. Abdominal visceral fat area is closely associated with insulin resistance.


Key words: 
Diabetes mellitus, type 2; Intra-abdominal fat; Insulin resistance; Male; Obesity
Diagnosis and differential diagnosis of diabetic kidney disease
Authors: Siruo Guo
Journal: BMJ (2017)

糖尿病肾病是重要的终末肾衰竭病因之一。糖尿病患者合并的肾脏损害包括糖尿病肾病和非糖尿病肾病，糖尿病肾病是由糖尿病引起的肾脏损害，主要包括尿白蛋白/肌酐比值(ACR)>30 mg/g或肾小球滤过率(GFR)< 60 ml·min－1·1.73 m－2持续超过3个月。诊断糖尿病肾病时要排除非糖尿病肾病，当糖尿病患者缺乏糖尿病视网膜病变、GFR快速下降、明显的血尿及快速出现的肾病综合征等临床征象时，要考虑非糖尿病肾病可能。鉴别困难时需行肾脏穿刺病理检查来鉴别。
Secukinumab Therapy for Netherton Syndrome
Authors: Isabelle Luchsinger, Nicole Knöpfel, Martin Theiler, Mathilde Bonnet des Claustres, Claire Barbieux, Agnes Schwieger-Briel, Corinne Brunner, Davide Donghi, Michael Buettcher, Barbara Meier-Schiesser, Alain Hovnanian, Lisa Weibel
Journal: JAMA Dermatology (2020)

Netherton syndrome (NS) is a rare, severe genetic disorder of cornification with high morbidity. Treatment for NS has been notoriously difficult. Recent studies showed an upregulated helper T cell (TH) 17/interleukin 23 (IL-23) pathway in NS, suggesting the possibility of treatment strategies that target IL-17.To evaluate the clinical response of NS to treatment with the IL-17 antagonist secukinumab.This case series study reports the experience of compassionate use therapy with secukinumab in 4 patients with severe NS, including 2 children, from December 1, 2018, to December 1, 2019, with 3 patients still undergoing treatment at the time of final analysis. Data were analyzed from December 1, 2018, to December 1, 2019.Expression of IL-17 in the skin was evaluated by immunohistochemical analysis, and serum cytokine concentrations were measured using a commercially available assay. Treatment response was assessed using the Ichthyosis Area and Severity Index (IASI) total score, including measures of erythema and scaling, the Dermatology Life Quality Index (DLQI), and the 5-D itch scale.In all 4 patients (age range, 9-27 years; 3 male and 1 female), immunostaining with an IL-17A antibody showed an increased number of positive cells in lesional skin. Cytokine assessment in serum samples revealed increased levels of CCL20. Treatment duration with secukinumab was 3 to 12 months at the time of this report. After 3 months of therapy, IASI scores were reduced by 44% to 88%, DLQI scores were reduced by 40% to 76%, and 5-D itch scale scores were reduced by 27% to 62%. This outcome was sustained at the 6-month follow-up. Two patients with an erythrodermic phenotype showed marked improvement of all parameters. A refractory palmoplantar eczematous eruption occurred in 2 patients, and a candidal nail infection developed in 2 patients. No severe adverse events were reported.This initial case series reporting the use of anti-IL-17 therapy in NS demonstrated marked cutaneous improvement, particularly in 2 pediatric patients with erythrodermic phenotypes. Further studies are needed to evaluate the long-term benefit of this potential treatment modality.