THU0574 DOES THE USE OF CHOLCHICINE EFFECT COGNITIVE FUNCTIONS IN FAMILIAL MEDITERRANEAN FEVER? PRELIMINARY STUDY
Authors: Halise Hande Gezer, Ozge Devezer Uslu, Didem Erdem, Sevtap Acer Kasman, Mehmet Tuncay Duruöz
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background:</h3> In Familial Mediterranean Fever (FMF), although cognitive functions have been shown to be impaired in children and adolescents, it has been shown that colchicine can be preservative on the cognitive functions in patients who are on long term colchicine treatment. <h3>Objectives:</h3> This study aimed to evaluate cognitive functions in adult patients with FMF and cognitive effects of colchicine use. <h3>Methods:</h3> The study included patients who were diagnosed with FMF according to Tel-Hashomer criteria. The control group included patients with no other inflamatory or systemic disease. Clinical features such as disease duration, comorbid diseases, colchicine treatment duration and dosage, amyloidosis and chronic renal failure (CRF), FMF gene mutation and PRAS scoring for evaluation of disease activity were recorded. Pittsburg Sleep Quality Index (PSQI), Fatigue Severity Scale, FMF Quality of Life Scale and Beck Depression Scale were used to assess patents clinical situations. Cognitive measurements were evaluated under executive-propellent functions. KAS test was used for information processing and fluency skills; fruit-name test was used for the evaluation of focusing, concentration, and attention skills; animal counting test and The Montreal Cognitive Rating Scale (MOCA) which can evaluate different subunits (visuospatial/executive, naming, memory, attention, language, abstraction, delayed recall, and orientation) were used for the fluency and maintenance of attention. Different attention parameters were evaluated for patients and healthy individuals. These attention parameters were; focusing, eloborate, sustainability, ability to pay attention to two information at the same time. Descriptive analysis was performed for all parameters. Mann-Whitney U-test and Spearman correlation coefficient were used to compare parameters. P &lt;0.05 was accepted as statistically significant. <h3>Results:</h3> The study included 24 (21 women, 3 men) patients with FMF and 10 (7 female, 3 male) age, sex and BMI matched healthy controls. The mean age of the patients and controls were 36.83 (SD:10.9) and 39.3(SD:8.6), respectively. No significant difference was found between FMF and healthy control groups regarding animal counting, KAS test, MOCA test, and subgroups. Only fruit-name counting test was decreased in the FMF group compared to the healthy controls (p &lt;0.05). As the duration of colchicine treatment was prolonged, a moderate positive correlation was found in KAS scores (r=0.511) and MOCA naming scores (r=0.445). In the FMF group, the number of attacks in the last three months and the sleep scores of Pittsburgh and depression scores had a moderate positively correlation (r = 0.496). Depression scores and quality of life scores were highly correlated (r = 0.631). <h3>Conclusion:</h3> FMF patients attention parameters are impaired compared to the healthy controls. Information processing and fluency performance is increased in FMF patients with the duration of colchicine treatment that demonstrate the ability to categorize and fluent use of the information. Number of attacks are correlated with poor sleep quality and depression. <h3>References:</h3> [1] Keskindemirci, G., et al., Does familial Mediterranean fever affect cognitive function in children? Electrophysiological preliminary study. Int J Neurosci, 2018. 128(1): p.10-14. [2] Leibovitz, A., et al., Colchicine therapy and the cognitive status of elderly patients with familial Mediterranean fever. Isr Med Assoc J, 2006. 8(7): p.469-72. <h3>Disclosure of Interests:</h3> Halise Hande Gezer: None declared, Ozge Devezer Uslu: None declared, Didem Erdem: None declared, Sevtap Acer Kasman: None declared, Mehmet Tuncay Duruöz Grant/research support from: Abvie, Speakers bureau: Novartis, AMGEN, Abdi İbrahim, İlko