tbuckley/cabot-search huggingface dataset:
Leydig Cell Function in Male Survivors of Childhood Cancer: A Report From the St Jude Lifetime Cohort Study
Authors: Wassim Chemaitilly, Qi Liu, Laura van Iersel, Kirsten K. Ness, Zhenghong Li, Carmen L. Wilson, Tara M. Brinkman, James L. Klosky, Nicole Barnes, Karen L. Clark, Rebecca M. Howell, Susan A. Smith, Matthew J. Krasin, Monika L. Metzger, Gregory T. Armstrong, Michael W. Bishop, Hanneke M. van Santen, Ching-Hon Pui, Deo Kumar Srivastava, Yutaka Yasui, Melissa M. Hudson, Leslie L. Robison, Daniel M. Green, Charles A. Sklar
Journal: Journal of Clinical Oncology (2019)

Direct assessment of Leydig cell function in childhood cancer survivors has been limited. The objectives of this study were to describe the prevalence of and risk factors for Leydig cell failure (LCF), Leydig cell dysfunction (LCD), and associated adverse health outcomes.In this retrospective study with cross-sectional health outcomes analysis, we evaluated 1,516 participants (median age, 30.8 years) at a median of 22.0 years after cancer diagnosis. LCF was defined as serum total testosterone less than 250 ng/dL (or 8.67 nmol/L) and luteinizing hormone greater than 9.85 IU/L, and LCD by testosterone as 250 ng/dL or greater and luteinizing hormone greater than 9.85 IU/L. Polytomous logistic regression evaluated associations with demographic and treatment-related risk factors. Log-binomial regression evaluated associations with adverse physical and psychosocial outcomes. Piecewise exponential models assessed the association with all-cause mortality.The prevalence of LCF and LCD was 6.9% and 14.7%, respectively. Independent risk factors for LCF included an age of 26 years or older at assessment, testicular radiotherapy at any dose, and alkylating agents at cyclophosphamide equivalent doses of 4,000 mg/m2 or greater. The risk increased with older age, higher doses of testicular radiotherapy, and cyclophosphamide equivalent doses. LCF was significantly associated with abdominal obesity, diabetes mellitus, erectile dysfunction, muscle weakness, and all-cause mortality. LCD was associated with unilateral orchiectomy and the same risk factors as LCF; no significant associations were found with adverse physical or psychosocial outcomes.Older age, testicular radiotherapy, and exposure to alkylating agents were associated with LCF, which was associated with adverse physical and psychosexual outcomes. LCD, although having similar risk factors, was not associated with adverse health outcomes. Additional studies are needed to investigate the role of sex hormone replacement in mitigating the burden from adverse outcomes in survivors.
TCT-830 Efficacy of PCSK-9 Inhibitors on Coronary Lipid Rich Plaque Assessed by Serial Near-Infrared Spectroscopy
Authors: Hiroyuki Omori, Hideaki Ota, Masahiko Hara, Yoshiaki Kawase, Toru Tanigaki, Tetsuo Hirata, Yoshihiro Sobue, Munenori Okubo, Hitoshi Matsuo
Journal: Journal of the American College of Cardiology (2019)
Deep Learning and Glaucoma Specialists
Authors: Sonia Phene, R. Carter Dunn, Naama Hammel, Yun Liu, Jonathan Krause, Naho Kitade, Mike Schaekermann, Rory Sayres, Derek J. Wu, Ashish Bora, Christopher Semturs, Anita Misra, Abigail E. Huang, Arielle Spitze, Felipe A. Medeiros, April Y. Maa, Monica Gandhi, Greg S. Corrado, Lily Peng, Dale R. Webster
Journal: Ophthalmology (2019)

PurposeTo develop and validate a deep learning (DL) algorithm that predicts referable glaucomatous optic neuropathy (GON) and optic nerve head (ONH) features from color fundus images, to determine the relative importance of these features in referral decisions by glaucoma specialists (GSs) and the algorithm, and to compare the performance of the algorithm with eye care providers.DesignDevelopment and validation of an algorithm.ParticipantsFundus images from screening programs, studies, and a glaucoma clinic.MethodsA DL algorithm was trained using a retrospective dataset of 86 618 images, assessed for glaucomatous ONH features and referable GON (defined as ONH appearance worrisome enough to justify referral for comprehensive examination) by 43 graders. The algorithm was validated using 3 datasets: dataset A (1205 images, 1 image/patient; 18.1% referable), images adjudicated by panels of GSs; dataset B (9642 images, 1 image/patient; 9.2% referable), images from a diabetic teleretinal screening program; and dataset C (346 images, 1 image/patient; 81.7% referable), images from a glaucoma clinic.Main Outcome MeasuresThe algorithm was evaluated using the area under the receiver operating characteristic curve (AUC), sensitivity, and specificity for referable GON and glaucomatous ONH features.ResultsThe algorithm's AUC for referable GON was 0.945 (95% confidence interval [CI], 0.929–0.960) in dataset A, 0.855 (95% CI, 0.841–0.870) in dataset B, and 0.881 (95% CI, 0.838–0.918) in dataset C. Algorithm AUCs ranged between 0.661 and 0.973 for glaucomatous ONH features. The algorithm showed significantly higher sensitivity than 7 of 10 graders not involved in determining the reference standard, including 2 of 3 GSs, and showed higher specificity than 3 graders (including 1 GS), while remaining comparable to others. For both GSs and the algorithm, the most crucial features related to referable GON were: presence of vertical cup-to-disc ratio of 0.7 or more, neuroretinal rim notching, retinal nerve fiber layer defect, and bared circumlinear vessels.ConclusionsA DL algorithm trained on fundus images alone can detect referable GON with higher sensitivity than and comparable specificity to eye care providers. The algorithm maintained good performance on an independent dataset with diagnoses based on a full glaucoma workup.
Is the Total Amount as Important as Localization and Type of Collagen in Liver Fibrosis Attributable to Steatohepatitis?
Authors: Morten A. Karsdal, Sönke Detlefsen, Samuel J. Daniels, Mette J. Nielsen, Aleksander Krag, Detlef Schuppan
Journal: Hepatology (2019)

Karsdal, Morten A.; Detlefsen, Sönke; Daniels, Samuel J.; Nielsen, Mette J.; Krag, Aleksander; Schuppan, Detlef Author Information
TCT-328 Diagnostic Performance of Quantitative Flow Ratio From Angiography Versus Fractional Flow Reserve From Computed Tomography
Authors: Hiroki Emori, Takashi Kubo, Toru Tanigaki, Yoshiaki Kawase, Yasutsugu Shiono, Kunihiro Shimamura, Yoshiki Matsuo, Yasushi Ino, Hitoshi Matsuo, Takashi Akasaka
Journal: Journal of the American College of Cardiology (2019)
Identifying the at risk smokers: who goes on to get COPD?
Authors: Arina Madan, Alice M. Turner
Journal: European Respiratory Journal (2019)

<b>Radiological measures of gas trapping, in particular due to small airways disease, may aid identification of smokers at risk of progression to COPD. Further research is needed on how to bring gas trapping measurement into routine clinical practice.</b>http://bit.ly/33QxC9F
TCT-535 Impact of Rapid Ventricular Pacing on Outcomes in Patient With Heart Failure After Transcatheter Aortic Valve Replacement: A Retrospective Analysis at a Community Hospital
Authors: Eduardo Venegas, Yash Jobanputra, Mark Rothenberg, Robert Chait, Marcos Nores, Sotiris Stamou
Journal: Journal of the American College of Cardiology (2019)
Need for Consensus Guidelines in Pediatric Umbilical Hernia Repair
Authors: Jonathan E. Kohler, Peter F. Nichol, Randi S. Cartmill
Journal: JAMA Pediatrics (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Annals Graphic Medicine - Child's Pose
Authors: Marjorie S. Rosenthal
Journal: Annals of Internal Medicine (2019)

Web Exclusives1 October 2019Annals Graphic Medicine - Child's PoseFREEMarjorie S. Rosenthal, MD, MPHMarjorie S. Rosenthal, MD, MPHSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/G18-0032 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Download figure Download PowerPoint Download figure Download PowerPoint Download figure Download PowerPoint Download figure Download PowerPoint Download figure Download PowerPoint Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: Disclosures: The author has disclosed no conflicts of interest. The form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=G18-0032.Author/Illustrator Information: Marjorie S. Rosenthal, MD, MPH, is a pediatrician, life-long student/researcher/writer/illustrator/teacher of how we best sustain all the bonds that tie us—from parenting to our communities (e-mail, Marjorie.[email protected]edu).This article was published at Annals.org on 24 September 2019. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 2019Volume 171, Issue 7Page: W38-W43KeywordsConflicts of interestDisclosureHealth care ePublished: 24 September 2019 Issue Published: 1 October 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
TCT-366 Novel Direct Visualization Technique Facilitates Safe and Reproducible Closure Post Large-Bore Sheath Removal: The FAST MANTA Pilot Study
Authors: Janarthanan Sathananthan, Mark Hensey, Thomas Gilhofer, Ashkan Parsa, Uri Landes, Abdullah Alkhodair, Madeleine Barker, Richard Cook, John Webb, David Wood
Journal: Journal of the American College of Cardiology (2019)
Multispecific Targeting with Synthetic Ankyrin Repeat Motif Chimeric Antigen Receptors
Authors: Ashwini Balakrishnan, Anusha Rajan, Alexander I. Salter, Paula L. Kosasih, Qian Wu, Jenna Voutsinas, Michael C. Jensen, Andreas Plückthun, Stanley R. Riddell
Journal: Clinical Cancer Research (2019)

The outgrowth of antigen-negative variants is a significant challenge for adoptive therapy with T cells that target a single specificity. Chimeric antigen receptors (CAR) are typically designed with one or two scFvs that impart antigen specificity fused to activation and costimulation domains of T-cell signaling molecules. We designed and evaluated the function of CARs with up to three specificities for overcoming tumor escape using Designed Ankyrin Repeat Proteins (DARPins) rather than scFvs for tumor recognition.A monospecific CAR was designed with a DARPin binder (E01) specific for EGFR and compared with a CAR designed using an anti-EGFR scFv. CAR constructs in which DARPins specific for EGFR, EpCAM, and HER2 were linked together in a single CAR were then designed and optimized to achieve multispecific tumor recognition. The efficacy of CAR-T cells bearing a multispecific DARPin CAR for treating tumors with heterogeneous antigen expression was evaluated in vivo.The monospecific anti-EGFR E01 DARPin conferred potent tumor regression against EGFR+ targets that was comparable with an anti-EGFR scFv CAR. Linking three separate DARPins in tandem was feasible and in an optimized format generated a single tumor recognition domain that targeted a mixture of heterogeneous tumor cells, each expressing a single antigen, and displayed synergistic activity when tumor cells expressed more than one target antigen.DARPins can serve as high-affinity recognition motifs for CAR design, and their robust architecture enables linking of multiple binders against different antigens to achieve functional synergy and reduce antigen escape.
TCT-11 Everolimus-Eluting Bioresorbable Scaffolds Versus Drug-Eluting Stents in Patients With Acute Myocardial Infarction: 2-Year Results of the Randomized ISAR-Absorb MI Trial
Authors: Jens Wiebe, Simon Schneider, Salvatore Cassese, Himanshu Rai, Petra Hoppmann, Roisin Colleran, Fernando Alfonso, Michael Maeng, Evgeny Kretov, Michael Joner, Karl-Ludwig Laugwitz, Adnan Kastrati, Robert Byrne
Journal: Journal of the American College of Cardiology (2019)
TCT-833 Inflammatory Risk Status Is Age-Dependent in Women but Not in Men Undergoing Percutaneous Coronary Intervention
Authors: Moritz Blum, Rishi Chandiramani, Roxana Mehran, Davide Cao, Samantha Sartori, Ridhima Goel, Anastasios Roumeliotis, Niklas Beyhoff, George Dangas, Usman Baber, Asaad Khan, Prakash Krishnan, Nitin Barman, Samin Sharma, Annapoorna Kini
Journal: Journal of the American College of Cardiology (2019)
TCT-117 Novel Optical Coherence Tomography Classification of Intravascular Lesions in Patients With Chronic Thromboembolic Pulmonary Hypertension Treated With Balloon Pulmonary Angioplasty
Authors: Aleksander Araszkiewicz, Stanislaw Jankiewicz, Sylwia Slawek, Maciej Grymuza, Tatiana Mularek-Kubzdela, Marek Grygier, Maciej Lesiak
Journal: Journal of the American College of Cardiology (2019)
Allowing more doctors to work less than full time could reduce burnout, says royal college
Authors: Abi Rimmer
Journal: BMJ (2019)

Flexible working patterns can help to prevent burnout and retain doctors in the NHS, the Royal College of Physicians of Edinburgh has said.

The college’s Trainees and Members’ Committee emailed 4200 medical trainees in the UK last November to survey them about their working conditions.1 They received 631 responses, a response rate of 15%.

The survey found that while 15% of trainees already worked less than full time (LTFT), two thirds (66%) of those who currently worked full time were considering reducing their hours in the future. …
Misdiagnosis of Type II Myocardial Infarction
Authors: Moussa A. Saleh, John A. Ambrose, Kassra Poosti, Chirag Rajyaguru, Marianna Sargsyan, Amir Najafi, Amarbir Bhullar, Uday Sandhu, Mohammad Hashmi, Charnjeet Sandhu
Journal: Journal of the American College of Cardiology (2019)
TCT-374 Residual Left Atrial Appendage Patency Identified by Early Computed Tomography Analysis Following Percutaneous Occlusion: Prevalence and Impact on Outcome
Authors: Khalil Mahmoudi, Simon Elhadad, Quentin Landolf, Frederic Sebag, Lalla Zhor Rezine, Jean-François Paul, Christophe Caussin, Nicolas Amabile
Journal: Journal of the American College of Cardiology (2019)
TCT-504 The Effect of Timing of Percutaneous Coronary Intervention Following Thrombolytic Therapy on the Outcome of Patients Presenting With Anterior ST-Segment Elevation Myocardial Infarction
Authors: Ahmad Alkonaissi, Ehab Aboal Magd, Moustafa Mokarrab, Ahmed Magdy, Ashraf Alamir
Journal: Journal of the American College of Cardiology (2019)
A Pragmatic Trial of Suicide Risk Assessment and Ambulance Transport Decision Making Among Emergency Medical Services Providers: Implications for Patient Consent
Authors: Benjamin S. Wilfond, Jennifer Zabrowski, Liza-Marie Johnson
Journal: The American Journal of Bioethics (2019)

"A Pragmatic Trial of Suicide Risk Assessment and Ambulance Transport Decision Making Among Emergency Medical Services Providers: Implications for Patient Consent." The American Journal of Bioethics, 19(10), pp. 97–98
Inhibition of MAP Kinase-Interacting Kinase-1 (Mnk1) Regulates Platelet Functional Responses and Protein Synthesis in Megakaryocytes
Authors: Bhanu Kanth Manne, Rachit Badolia, Robert A. Campbell, Satya P. Kunapuli, Andrew S. Weyrich, Matthew T. Rondina
Journal: Blood (2016)
Chlorogenic acid effectively treats cancers through induction of cancer cell differentiation
Authors: Shuai Huang, Lu-Lu Wang, Ni-Na Xue, Cong Li, Hui-Hui Guo, Tian-Kun Ren, Yun Zhan, Wen-Bing Li, Jie Zhang, Xiao-Guang Chen, Yan-Xing Han, Jin-Lan Zhang, Jian-Dong Jiang
Journal: Theranostics (2019)

Inducing cancer differentiation is a promising approach to treat cancer. Here, we identified chlorogenic acid (CA), a potential differentiation inducer, for cancer therapy, and elucidated the molecular mechanisms underlying its differentiation-inducing effects on cancer cells.Cancer cell differentiation was investigated by measuring malignant behavior, including growth rate, invasion/migration, morphological change, maturation, and ATP production. Gene expression was analyzed by microarray analysis, qRT-PCR, and protein measurement, and molecular biology techniques were employed for mechanistic studies. LC/MS analysis was the method of choice for chemical detection. Finally, the anticancer effect of CA was evaluated both in vitro and in vivo. Results: Cancer cells treated with CA showed reduced proliferation rate, migration/invasion ability, and mitochondrial ATP production. Treating cancer cells with CA resulted in elevated SUMO1 expression through acting on its 3'UTR and stabilizing the mRNA. The increased SUMO1 caused c-Myc sumoylation, miR-17 family downregulation, and p21 upregulation leading to G0/G1 arrest and maturation phenotype. CA altered the expression of differentiation-related genes in cancer cells but not in normal cells. It inhibited hepatoma and lung cancer growth in tumor-bearing mice and prevented new tumor development in naïve mice. In glioma cells, CA increased expression of specific differentiation biomarkers Tuj1 and GFAP inducing differentiation and reducing sphere formation. The therapeutic efficacy of CA in glioma cells was comparable to that of temozolomide. CA was detectable both in the blood and brain when administered intraperitoneally in animals. Most importantly, CA was safe even at very high doses.CA might be a safe and effective differentiation-inducer for cancer therapy. "Educating" cancer cells to differentiate, rather than killing them, could be a novel therapeutic strategy for cancer.
TCT-827 Relationship Between Hemoglobin A1C and Coronary Plaque Vulnerability in Patients Undergoing Percutaneous Coronary Intervention: An Optical Coherence Tomography Study
Authors: Naotaka Okamoto, Nitin Barman, Yuliya Vengrenyuk, Keisuke Yasumura, Benjamin Benhuri, Surbhi Chamaria, Samit Bhatheja, Samin Sharma, Jagat Narula, Annapoorna Kini, Usman Baber
Journal: Journal of the American College of Cardiology (2019)
TCT-448 Left Ventricular Meridional Systolic Wall Stress Predicts Heart Failure Readmissions in Patients Undergoing Transcatheter Mitral Valve Repair
Authors: Srilekha Sridhara, Abhishek Sawant, Nidhi Kanwar, Edward Distler, Srujal Patel, Siamac Yazdchi, Adnan Habib, Janelle Rodriguez, Meghana Prakash Hiriyur Prakash, Meenakshi Sridhar, Arnav Kumar, Philipp Wiesner, Ashish Pershad
Journal: Journal of the American College of Cardiology (2019)
Screening for Asymptomatic Bacteriuria in Adults
Authors: Douglas K. Owens, Karina W. Davidson, Alex H. Krist, Michael J. Barry, Michael Cabana, Aaron B. Caughey, Chyke A. Doubeni, John W. Epling, Martha Kubik, C. Seth Landefeld, Carol M. Mangione, Lori Pbert, Michael Silverstein, Melissa A. Simon, Chien-Wen Tseng, John B. Wong
Journal: JAMA (2019)

<h3>Importance</h3> Among the general adult population, women (across all ages) have the highest prevalence of asymptomatic bacteriuria, although rates increase with age among both men and women. Asymptomatic bacteriuria is present in an estimated 1% to 6% of premenopausal women and an estimated 2% to 10% of pregnant women and is associated with pyelonephritis, one of the most common nonobstetric reasons for hospitalization in pregnant women. Among pregnant persons, pyelonephritis is associated with perinatal complications including septicemia, respiratory distress, low birth weight, and spontaneous preterm birth. <h3>Objective</h3> To update its 2008 recommendation, the USPSTF commissioned a review of the evidence on potential benefits and harms of screening for and treatment of asymptomatic bacteriuria in adults, including pregnant persons. <h3>Population</h3> This recommendation applies to community-dwelling adults 18 years and older and pregnant persons of any age without signs and symptoms of a urinary tract infection. <h3>Evidence Assessment</h3> Based on a review of the evidence, the USPSTF concludes with moderate certainty that screening for and treatment of asymptomatic bacteriuria in pregnant persons has moderate net benefit in reducing perinatal complications. There is adequate evidence that pyelonephritis in pregnancy is associated with negative maternal outcomes and that treatment of screen-detected asymptomatic bacteriuria can reduce the incidence of pyelonephritis in pregnant persons. The USPSTF found adequate evidence of harms associated with treatment of asymptomatic bacteriuria (including adverse effects of antibiotic treatment and changes in the microbiome) to be at least small in magnitude. The USPSTF concludes with moderate certainty that screening for and treatment of asymptomatic bacteriuria in nonpregnant adults has no net benefit. The known harms associated with treatment include adverse effects of antibiotic use and changes to the microbiome. Based on these known harms, the USPSTF determined the overall harms to be at least small in this group. <h3>Recommendations</h3> The USPSTF recommends screening pregnant persons for asymptomatic bacteriuria using urine culture. (B recommendation) The USPSTF recommends against screening for asymptomatic bacteriuria in nonpregnant adults. (D recommendation)
TCT-782 Slender Distal Transradial Access for Complex Percutaneous Coronary Intervention: A Case-Matched Comparison With Classical Radial Approach
Authors: Gregory Sgueglia, Francesco Summaria, Gaetano Gioffrè, Fabiana Piccioni, Fabrizio D’Errico, Maria Benedetta Giannico, Achille Gaspardone
Journal: Journal of the American College of Cardiology (2019)
High Amount of PD-L1+Tumor Associated Macrophages Is Associated with Better Survival in Patients with Primary Testicular Lymphoma
Authors: Marjukka Pollari, Oscar Bruck, Suvi-Katri Leivonen, Teijo Pellinen, Pauli Vahamurto, Marja-Liisa Karjalainen-Lindsberg, Susanna Mannisto, Pirkko-Liisa Kellokumpu-Lehtinen, Satu Mustjoki, Sirpa Leppa
Journal: Blood (2017)