tbuckley/cabot-search huggingface dataset:
Combined endoscopic and surgical management of small-bowel polyposis in a patient with Peutz-Jeghers syndrome
Authors: Feng Li, Neal Mehta, David Liska, Beatrice Dionigi, Matthew F. Kalady, Carol A. Burke, Amit Bhatt
Journal: Endoscopy (2019)

Peutz-Jeghers syndrome (PJS) is a hereditary condition characterized by hamartomatous polyps throughout the gastrointestinal tract, typically in the small bowel and colon [1] [2]. PJS carries an increased cancer risk and requires lifelong surveillance in order to detect polyps that may cause both intussusception/obstruction and cancer [1] [2].
TCT-158 Intracoronary CD34+ Cell Therapy Further Improves 1-Year Left Ventricular Systolic Function in Patients With Concomitant Severe Diffuse Coronary Artery Disease and Preserved Cardiac Performance
Authors: Pei-Hsun Sung, Hon-Kan Yip, Chiung-Jen Wu
Journal: Journal of the American College of Cardiology (2019)
Performance of Breast Cancer Risk-Assessment Models in a Large Mammography Cohort
Authors: Anne Marie McCarthy, Zoe Guan, Michaela Welch, Molly E Griffin, Dorothy A Sippo, Zhengyi Deng, Suzanne B Coopey, Ahmet Acar, Alan Semine, Giovanni Parmigiani, Danielle Braun, Kevin S Hughes
Journal: JNCI Journal of the National Cancer Institute (2019)

Several breast cancer risk-assessment models exist. Few studies have evaluated predictive accuracy of multiple models in large screening populations.We evaluated the performance of the BRCAPRO, Gail, Claus, Breast Cancer Surveillance Consortium (BCSC), and Tyrer-Cuzick models in predicting risk of breast cancer over 6 years among 35 921 women aged 40-84 years who underwent mammography screening at Newton-Wellesley Hospital from 2007 to 2009. We assessed model discrimination using the area under the receiver operating characteristic curve (AUC) and assessed calibration by comparing the ratio of observed-to-expected (O/E) cases. We calculated the square root of the Brier score and positive and negative predictive values of each model.Our results confirmed the good calibration and comparable moderate discrimination of the BRCAPRO, Gail, Tyrer-Cuzick, and BCSC models. The Gail model had slightly better O/E ratio and AUC (O/E = 0.98, 95% confidence interval [CI] = 0.91 to 1.06, AUC = 0.64, 95% CI = 0.61 to 0.65) compared with BRCAPRO (O/E = 0.94, 95% CI = 0.88 to 1.02, AUC = 0.61, 95% CI = 0.59 to 0.63) and Tyrer-Cuzick (version 8, O/E = 0.84, 95% CI = 0.79 to 0.91, AUC = 0.62, 95% 0.60 to 0.64) in the full study population, and the BCSC model had the highest AUC among women with available breast density information (O/E = 0.97, 95% CI = 0.89 to 1.05, AUC = 0.64, 95% CI = 0.62 to 0.66). All models had poorer predictive accuracy for human epidermal growth factor receptor 2 positive and triple-negative breast cancers than hormone receptor positive human epidermal growth factor receptor 2 negative breast cancers.In a large cohort of patients undergoing mammography screening, existing risk prediction models had similar, moderate predictive accuracy and good calibration overall. Models that incorporate additional genetic and nongenetic risk factors and estimate risk of tumor subtypes may further improve breast cancer risk prediction.
Italian university rectors for health and environment: the U4ALL initiative
Authors: Alessandro Miani, Prisco Piscitelli, Antonio Felice Uricchio, Elio Franzini, Francesco Frati, Renato Lauro, Vincenzo Zara, Gianni Profita, Angelo Deiana, Annamaria Colao, Gaetano Manfredi
Journal: The Lancet (2019)
TCT-655 Adverse Cardiac Events Among Patients Undergoing Coronary Orbital Atherectomy: A Pooled Meta-Analysis of 2,303 Procedures
Authors: Rupak Desai, Kiranmayi Kakumani, Sandeep Singh, Arnav Kumar, Muhammad Uzair Lodhi, Muhammad Haisum Maqsood, Abhishek Sawant, Ashish Pershad, Yiannis Chatzizisis, Pranav Loyalka, Rajesh Sachdeva, Gautam Kumar
Journal: Journal of the American College of Cardiology (2019)
Rapid B-Cell Recovery Is Predictive of Graft-Versus-Host Disease-Free Survival, Few Infectious Events, and Good Quality-of-Life after Cord Blood Transplantation Using Myeloablative Regimen without Antithymocyte Globulin
Authors: Liu Huilan, Sun Zimin, Zhu Xiaoyu, Baolin Tang, Changcheng Zheng, TONG Juan, Song Kaidi, Zhang Lei, Xiu Han, Yao Wen, Sun Guangyu, Wu Yue, Wang Xingbing, Ding Kaiyang, Ding Bangsheng, Zhang Aimei, Geng Liangquan, Wan Xiang
Journal: Blood (2016)
The Role of Sex and Sex Hormones in Neurodegenerative Diseases
Authors: Elisabetta Vegeto, Alessandro Villa, Sara Della Torre, Valeria Crippa, Paola Rusmini, Riccardo Cristofani, Mariarita Galbiati, Adriana Maggi, Angelo Poletti
Journal: Endocrine Reviews (2019)

Abstract Neurodegenerative diseases (NDs) are a wide class of disorders of the central nervous system (CNS) with unknown etiology. Several factors were hypothesized to be involved in the pathogenesis of these diseases, including genetic and environmental factors. Many of these diseases show a sex prevalence and sex steroids were shown to have a role in the progression of specific forms of neurodegeneration. Estrogens were reported to be neuroprotective through their action on cognate nuclear and membrane receptors, while adverse effects of male hormones have been described on neuronal cells, although some data also suggest neuroprotective activities. The response of the CNS to sex steroids is a complex and integrated process that depends on (i) the type and amount of the cognate steroid receptor and (ii) the target cell type—either neurons, glia, or microglia. Moreover, the levels of sex steroids in the CNS fluctuate due to gonadal activities and to local metabolism and synthesis. Importantly, biochemical processes involved in the pathogenesis of NDs are increasingly being recognized as different between the two sexes and as influenced by sex steroids. The aim of this review is to present current state-of-the-art understanding on the potential role of sex steroids and their receptors on the onset and progression of major neurodegenerative disorders, namely, Alzheimer’s disease, Parkinson’s diseases, amyotrophic lateral sclerosis, and the peculiar motoneuron disease spinal and bulbar muscular atrophy, in which hormonal therapy is potentially useful as disease modifier.
Assessing the utility of Magneto to control neuronal excitability in the somatosensory cortex
Authors: Koen Kole, Yiping Zhang, Eric J. R. Jansen, Terence Brouns, Ate Bijlsma, Niccolo Calcini, Xuan Yan, Angelica da Silva Lantyer, Tansu Celikel
Journal: Nature Neuroscience (2019)
Boosting Naloxone Prescribing
Authors: Bridget Kuehn
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erratum. Baseline Characteristics of the Vitamin D and Type 2 Diabetes (D2d) Study: A Contemporary Prediabetes Cohort That Will Inform Diabetes Prevention Efforts. Diabetes Care 2018;41:1590–1599
Authors: Erin S. LeBlanc, Richard E. Pratley, Bess Dawson-Hughes, Myrlene A. Staten, Patricia R. Sheehan, Michael R. Lewis, Anne Peters, Sun H. Kim, Ranee Chatterjee, Vanita R. Aroda, Chhavi Chadha, Lisa M. Neff, Irwin G. Brodsky, Clifford Rosen, Cyrus V. Desouza, John P. Foreyt, Daniel S. Hsia, Karen C. Johnson, Philip Raskin, Sangeeta R. Kashyap, Patrick O’Neil, Lawrence S. Phillips, Neda Rasouli, Emilia P. Liao, David C. Robbins, Anastassios G. Pittas
Journal: Diabetes Care (2019)

In the article cited above, there were some differences in means and proportions of a few variables between the published data and …
TCT-182 Peristrut Low-Intensity Areas and Neointimal Response Evaluation by Serial Optical Coherence Tomography at Baseline and 1, 2, and 5 Years After Bioresorbable Scaffold Implantation in STEMI
Authors: Dorota Ochijewicz, Mariusz Tomaniak, Lukasz Koltowski, Arkadiusz Pietrasik, Piotr Barus, Zenon Huczek, Krzysztof Filipiak, Grzegorz Opolski, Janusz Kochman
Journal: Journal of the American College of Cardiology (2019)
Parent-Toddler Social Reciprocity During Reading From Electronic Tablets vs Print Books
Authors: Tiffany G. Munzer, Alison L. Miller, Heidi M. Weeks, Niko Kaciroti, Jenny Radesky
Journal: JAMA Pediatrics (2019)

Although the American Academy of Pediatrics recommends parent-child joint engagement with digital media, recent evidence suggests this may be challenging when tablets contain interactive enhancements.
TCT-417 Influence of Thrombotic and Bleeding Risk on P2Y12 Receptor Inhibitor Choice in ACS After PCI: Insights From a Large Single-Center Registry
Authors: Ada Ip, Usman Baber, George Dangas, Joseph Sweeny, Nitin Barman, Asaad Khan, Jason Kovacic, Annapoorna Kini, Samin Sharma, Roxana Mehran
Journal: Journal of the American College of Cardiology (2019)
Publication Bias in Trials With and Without Null Findings—Reply
Authors: James A. Heathers, Jason M. Nagata, Stuart B. Murray
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Psychotic Experiences in the General Population
Authors: Albert R. Powers
Journal: JAMA Psychiatry (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
TCT-456 Pre-Existing Atrial Fibrillation Is Associated With Increased Risk of Mid-Term and Long-Term Mortality in Transcatheter Mitral Valve Repair: Systemic Review and Meta-Analysis
Authors: Narut Prasitlumkum, Nath Limpruttidham, Veraprapas Kittipibul, Jakrin Kewcharoen, Tanawan Riangwiwat, Pattara Rattanawong
Journal: Journal of the American College of Cardiology (2019)
Sorafenib (S) for hepatocellular carcinoma (HCC) treatment: Russian experience in cirrhotic (C) and non-cirrhotic (non-C) patients.
Authors: Valeriy Vladimirovich Breder, Yulia Bisovskaya, Svetlana Victorovna Khokhlova, Vera Gorbunova
Journal: Journal of Clinical Oncology (2012)

e14723 Background: S is the standard for HCC treatment in advanced stage. There is no date about an etiology of HCC and S efficacy/toxicity in Russian pts. Methods: 69 patients (19 f/ 50 m, average age 54 years) with advanced HCC BCLC A/B/C/D 1/30/38/0 were treated with sorafenib as a I-st line. S treatment: 400 mg bid until progression, uncontrolled toxicity, or death. S dose reduced when toxicity (NCI CTC, ver 3.0) ≥Gr 2 occured. We evaluate influences of BCLC and Child-Pugh stage, presence of C and/or viral hepatitis on S efficacy and toxicity. Results: 33 (48%) out of 69 patients had C and 36 (52%) were non-C. No hepatitis - 36 pts (C/non-C - 5/31 pts), 16 pts had HBV (C/non-C – 15/1), 17 pts had HCV (C/non-C – 15/2), 1 pt had hepatitis B+/C without C. Clinically significant toxicity (Gr 2/3) occurred in 20 (C/non-C – 9/12) pts: HFS 1/6, skin rash 3/3, diarrhea 3/2, arterial hypertension (AG) 2/0, asthenia 1/1, fever 1/0. S interrupted in 12 (C/non-C – 5/7) pts: HFS- 0/4, skin rash -1/3 diarrhea - 2/1 and AG - 2/0. Efficacy evaluated in 68 pts: PR - 5 (7,4%) pts, stable – 46 (67,6%) and disease progressed in 17 (25%) pts. All PR (OR=13,9%) observed in non-C pts: 6, 9,3, 10, 10,2 and 13+ mo). Median PFS and OS on S treatment was 5,4 and 9,3 mo respectively. No significant difference were in PFS and OS for C and non-C pts, irrespectively for HCV/HBV status and Child-Pugh stage A/B (Table). Conclusions: More than 50% of HCC pts in Russia are non-C and don’t have HBV/HCV. Clinically significant toxicity of S differs in C/non-C pts, with prevalence of skin side effects in non-C pts, AG and diarrhea in C group. Non-C HCC pts have better chance to respond to S treatment. However we didn’t find any significant difference of S treatment in terms of survival and side effects between C and non-C pts. [Table: see text]
Euthanasia for Mental Suffering Reduces Stigmatization But May Lead to an Extension of This Practice Without Safeguards
Authors: A. Le Glaz, S. Berrouiguet, Deok-Hee Kim-Dufor, M. Walter, C. Lemey
Journal: The American Journal of Bioethics (2019)

In Europe, euthanasia for mental suffering related to a psychiatric disease is allowed in different ways in three countries (the Netherlands, Belgium, Switzerland). In Belgium, the law decriminaliz...
Time-to-progression after front-line fludarabine, cyclophosphamide, and rituximab chemoimmunotherapy for chronic lymphocytic leukaemia: a retrospective, multicohort study
Authors: Carmen D Herling, Kevin R Coombes, Axel Benner, Johannes Bloehdorn, Lynn L Barron, Zachary B Abrams, Tadeusz Majewski, Jolanta E Bondaruk, Jasmin Bahlo, Kirsten Fischer, Michael Hallek, Stephan Stilgenbauer, Bogdan A Czerniak, Christopher C Oakes, Alessandra Ferrajoli, Michael J Keating, Lynne V Abruzzo
Journal: The Lancet Oncology (2019)
β <sub>2</sub> -Adrenergic Stimulation Compartmentalizes β <sub>1</sub> Signaling Into Nanoscale Local Domains by Targeting the C-Terminus of β <sub>1</sub> -Adrenoceptors
Authors: Hua-Qian Yang, Li-Peng Wang, Yun-Yun Gong, Xue-Xin Fan, Si-Yu Zhu, Xiao-Ting Wang, Yu-Pu Wang, Lin-Lin Li, Xin Xing, Xiao-Xiao Liu, Guang-Shen Ji, TingTing Hou, Yan Zhang, Rui-Ping Xiao, Shi-Qiang Wang
Journal: Circulation Research (2019)

βARs (β-adrenergic receptors) are prototypical GPCRs (G protein-coupled receptors) that play a pivotal role in sympathetic regulation. In heart cells, β1AR signaling mediates a global response, including both l-type Ca2+ channels in the sarcolemma/T tubules and RyRs (ryanodine receptors) in the SR (sarcoplasmic reticulum). In contrast, β2AR mediates local signaling with little effect on the function of SR proteins.To investigate the signaling relationship between β1ARs and β2ARs.Using whole-cell patch-clamp analyses combined with confocal Ca2+ imaging, we found that the activation of compartmentalized β2AR signaling was able to convert the β1AR signaling from global to local mode, preventing β1ARs from phosphorylating RyRs that were only nanometers away from sarcolemma/T tubules. This offside compartmentalization was eliminated by selective inhibition of β2AR, GRK2 (GPCR kinase-2), βarr1 (β-arrestin-1), and phosphodiesterase-4. A knockin rat model harboring mutations of the last 3 serine residues of the β1AR C terminus, a component of the putative βarr1 binding site and GRK2 phosphorylation site, eliminated the offside compartmentalization conferred by β2AR activation.β2AR stimulation compartmentalizes β1AR signaling into nanoscale local domains in a phosphodiesterase-4-dependent manner by targeting the C terminus of β1ARs. This finding reveals a fundamental negative feed-forward mechanism that serves to avoid the cytotoxicity of circulating catecholamine and to sharpen the transient β1AR response of sympathetic excitation.
To What Target Hemoglobin A<sub>1c</sub> Level Would You Treat This Patient With Type 2 Diabetes?
Authors: Gerald W. Smetana, David M. Nathan, David C. Dugdale, Risa B. Burns
Journal: Annals of Internal Medicine (2019)

In the United States, 9.4% of all adults—and 25% of those older than 65 years—have diabetes. Diabetes is the leading cause of blindness and end-stage renal disease and contributes to both microvascular and macrovascular complications. The management of patients with type 2 diabetes (T2D) is a common and important activity in primary care internal medicine practice. Measurement of hemoglobin A1c (HbA1c) provides an estimate of mean blood sugar levels and glycemic control. The optimal HbA1c target level among various persons with T2D is a subject of controversy. Guidelines regarding HbA1c targets have yielded differing recommendations. In 2018, the American College of Physicians (ACP) published a guideline on HbA1c targets for nonpregnant adults with T2D. In addition to a recommendation to individualize HbA1c target levels, the ACP proposed a level between 7% and 8% for most patients. The ACP also advised deintensification of therapy for patients who have an HbA1c level lower than 6.5% and avoidance of HbA1c-targeted treatment for patients with a life expectancy of less than 10 years. This guidance contrasts with a recommendation from the American Diabetes Association to aim for HbA1c levels less than 7% for many nonpregnant adults and to consider a target of 6.5% if it can be achieved safely. Here, 2 experts, a diabetologist and a general internist, discuss how to apply the divergent guideline recommendations to a patient with long-standing T2D and a current HbA1c level of 7.8%.
TCT-33 Bioprosthetic Valve Fracture Performed Pre– Versus Post–Valve-in-Valve Transcatheter Aortic Valve Replacement: Insights From Bench Testing
Authors: Janarthanan Sathananthan, Rob Fraser, Hoda Hatoum, Aaron Barlow, Viktória Stanová, Mark Hensey, Uri Landes, Abdullah Alkhodair, Stephanie Sellers, Anson Cheung, Jian Ye, Keith Allen, Adnan Chhatriwalla, Philipp Blanke, Régis Rieu, Philippe Pibarot, Lakshmi Dasi, Jonathon Leipsic, David Wood, John Webb
Journal: Journal of the American College of Cardiology (2019)
Catalytic dysregulation of SHP2 leading to Noonan syndromes affects platelet signaling and functions
Authors: Marie Bellio, Cédric Garcia, Thomas Edouard, Sophie Voisin, Benjamin G. Neel, Cendrine Cabou, Philippe Valet, Jun Mori, Alexandra Mazharian, Yotis A. Senis, Armelle Yart, Bernard Payrastre, Sonia Severin
Journal: Blood (2019)
TCT-539 Novel Predictors of New Persistent Left Bundle Branch Block after Edwards Sapien 3 TAVR.
Authors: Syed Zaid, H.A.S.A.N. AHMAD, Asaad Khan, Ryan Kaple, Cenap Undemir, Jason Kovacic, Steven Lansman, George Dangas, Samin Sharma, Annapoorna Kini, Gilbert Tang
Journal: Journal of the American College of Cardiology (2019)
TCT-327 Feasibility of IVUS-Derived FFR as a Novel Technique to Estimate Functional Severity of Coronary Stenosis
Authors: Kuninobu Kashiyama, Shinjo Sonoda, Kensuke Matsushita, Kozo Okada, Eiichi Akiyama, Yasushi Matsuzawa, Nobuhiko Maejima, Noriaki Iwahashi, Kengo Tsukahara, Masami Kosuge, Toshiaki Ebina, Kiyoshi Hibi, Kouichi Tamura, Kazuo Kimura, M. Brooke Hollak, Paul G. Yock, Alan C. Yeung, Yasuhiro Honda
Journal: Journal of the American College of Cardiology (2019)
TCT-737 Balloon Expandable Versus Self Expanding Transcatheter Aortic Valve Systems: A Bayesian Network Meta-Analysis
Authors: Mohammed Osman, Yasir Abdul Ghaffar, Maryam Saleem, Babikir Kheiri, Khansa Osman, Muhamad Munir, Mohamad Alkhouli
Journal: Journal of the American College of Cardiology (2019)
Preeclampsia and Cardiovascular Disease in a Large UK Pregnancy Cohort of Linked Electronic Health Records
Authors: Lydia J. Leon, Fergus P. McCarthy, Kenan Direk, Arturo Gonzalez-Izquierdo, David Prieto-Merino, Juan P. Casas, Lucy Chappell
Journal: Circulation (2019)

Background: The associations between pregnancy hypertensive disorders and common cardiovascular disorders have not been investigated at scale in a contemporaneous population. We aimed to investigate the association between preeclampsia, hypertensive disorders of pregnancy, and subsequent diagnosis of 12 different cardiovascular disorders. Methods: We used linked electronic health records from 1997 to 2016 to recreate a UK population-based cohort of 1.3 million women, mean age at delivery 28 years, with nearly 1.9 million completed pregnancies. We used multivariable Cox models to determine the associations between hypertensive disorders of pregnancy, and preeclampsia alone (term and preterm), with 12 cardiovascular disorders in addition to chronic hypertension. We estimated the cumulative incidence of a composite end point of any cardiovascular disorder according to preeclampsia exposure. Results: During the 20-year study period, 18 624 incident cardiovascular disorders were observed, 65% of which had occurred in women under 40 years. Compared to women without hypertension in pregnancy, women who had 1 or more pregnancies affected by preeclampsia had a hazard ratio of 1.9 (95% confidence interval 1.53–2.35) for any stroke, 1.67 (1.54–1.81) for cardiac atherosclerotic events, 1.82 (1.34–2.46) for peripheral events, 2.13 (1.64–2.76) for heart failure, 1.73 (1.38–2.16) for atrial fibrillation, 2.12 (1.49–2.99) for cardiovascular deaths, and 4.47 (4.32–4.62) for chronic hypertension. Differences in cumulative incidence curves, according to preeclampsia status, were apparent within 1 year of the first index pregnancy. Similar patterns of association were observed for hypertensive disorders of pregnancy, while preterm preeclampsia conferred slightly further elevated risks. Conclusions: Hypertensive disorders of pregnancy, including preeclampsia, have a similar pattern of increased risk across all 12 cardiovascular disorders and chronic hypertension, and the impact was evident soon after pregnancy. Hypertensive disorders of pregnancy should be considered as a natural screening tool for cardiovascular events, enabling cardiovascular risk prevention through national initiatives.