tbuckley/cabot-search huggingface dataset:
Core content of the medical school surgical curriculum: Consensus report from the association of surgeons in training (ASIT)
Authors: Daniel Baker, Praveena Deekonda, James Glasbey, Gemma Humm, Helen Mohan, Deirdre Nally, Nisaharan Srikandarajah, Bradley Storey, Nathan Walker, Samuel Brown, Ioan Hughes, Bryony Peiris, Bhavesh Tailor, Gauri Vithlani, Katarzyna Wcislo, Sam Webb, Niall Adams, Waheed-Ul-Rahman Ahmed, Saima Azam, Sanchita Bhatia, Paris Bratsos, Hamzah Choudhry, Rebecca Clementi, Rachael Coulson, Clare Cunningham, Keegan Curlewis, Aleksander Dawidziuk, Hayley Donnelly, Marios Erotocritou, Jonathan Hagan, Chloe Jacklin, Pramath Kakodkar, Mariam Kenner, Jessica Kennett, Rachel Khaw, Christopher Madden-McKee, Leo Mansell, James McNulty, Emily Mills, Tahira Mohamed, Wee Xuan Neo, Nathan Ng, Cleo Ngadimin, Mikhail Nozdrin, Matthew O'Donnell, Emma Obiri-Darko, Kamashi Pandirajan, Jeffy Paul, James Prentice, Priyanka Pujara, Polly Rubinchik, Riya Sawhney, Salonee Shah, Elliott Sharp, Lee Keng Siang, Thomas Smith, Bartosz Szyszka, Ngan Hong Ta, Dharmesh Valand, Heather White, James Worthington, Won Young Yoon, Andrew Ablett, Hannah Cornwall, Billy Down, Claudia Eichenauer, Ella Evans, Lucy Hoade, Imogen John, Kayani Kayani, Omar Kouli, Hemant Kumar, Richard Mak, Amelia Milton, Muhammed Noor, Olutusen Onafowokan, Georgios Solomou, Laura Tincknell, Baasil Yusuf, Alexander Zagaran, Daniel Baker, Praveena Deekonda, James Glasbey, Gemma Humm, Helen Mohan, Deirdre Nally, Nisaharan Srikandarajah, Bradley Storey, Nathan Walker, Daniel Baker, Samuel Brown, Ioan Hughes, Bryony Peiris, Bhavesh Tailor, Gauri Vithlani, Katarzyna Wcislo, Sam Webb, Niall Adams, Waheed-Ul-Rahman Ahmed, Saima Azam, Sanchita Bhatia, Paris Bratsos, Samuel Brown, Hamzah Choudhry, Rebecca Clementi, Rachael Coulson, Clare Cunningham, Keegan Curlewis, Aleksander Dawidziuk, Hayley Donnelly, Marios Erotocritou, Jonathan Hagan, Katie Hughes, Chloe Jacklin, Pramath Kakodkar, Mariam Kenner, Jessica Kennett, Rachel Khaw, Christopher Madden-McKee, Leo Mansell, James McNulty, Emily Mills, Tahira Mohamed, Wee Xuan Neo, Nathan Ng, Cleo Ngadimin, Mikhail Nozdrin, Matthew O'Donnell, Emma Obiri-Darko, Kamashi Pandirajan, Jeffy Paul, Bryony Peiris, James Prentice, Priyanka Pujara, Polly Rubinchik, Riya Sawhney, Salonee Shah, Elliott Sharp, Lee Keng Siang, Thomas Smith, Bartosz Szyszka, Ngan Hong Ta, Bhavesh Tailor, Dharmesh Valand, Gauri Vithlani, Katarzyna Wcislo, Sam Webb, Heather White, James Worthington, Won Young Yoon, Andrew Ablett, Hannah Cornwall, Billy Down, Claudia Eichenauer, Ella Evans, Lucy Hoade, Imogen John, Kayani Kayani, Omar Kouli, Hemant Kumar, Richard Mak, Emily Mills, Amelia Milton, Muhammed Noor, Matthew O'Donnell, Olutusen Onafowokan, Georgios Solomou, Laura Tincknell, Katarzyna Wcislo, Baasil Yusuf, Alexander Zagaran
Journal: International Journal of Surgery (2020)
Extrapolation Pitfalls and Methodology Flaws in Curing Anemia via Parental Education and Counseling—Reply
Authors: Arun S. Shet, Merrick Zwarenstein, Maria Rosaria Galanti
Journal: JAMA Pediatrics (2020)

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Study on Micrometastasis in Sentinel Lymph Node of Patients With Breast Cancer
Authors: D. Pérez Callejo, E. Almagro Casado, B. Cantos, C. González-Lois, A. Ruiz-Valdepeñas, M. Palka, Á. Ortiz, C. Maximiano, M. Méndez García, M. Provencio Pulla
Journal: Annals of Oncology (2012)
Case 1-2020: An 11-Year-Old Boy with Vomiting and Weight Loss
Authors: Alessio Fasano, Maureen M. Leonard, Deborah M. Mitchell, George Eng
Journal: New England Journal of Medicine (2020)

An 11-year-old boy was evaluated at the hospital because of ongoing vomiting and weight loss. Endoscopic evaluation revealed erythema of the gastric antrum and moderately scalloped mucosa of the duodenum; 11 days later, the patient had a syncopal episode. The patient was admitted to the hospital, additional diagnostic tests were performed, and a diagnosis was made.
Rifampin-moxifloxacin-metronidazole combination therapy for severe Hurley stage 1 hidradenitis suppurativa: prospective short-term trial and 1-year follow-up in 28 consecutive patients
Authors: Maïa Delage, Jean-Philippe Jais, Thi Lam, Hélène Guet-Revillet, Marie-Noelle Ungeheuer, Paul-Henri Consigny, Aude Nassif, Olivier Join-Lambert
Journal: Journal of the American Academy of Dermatology (2020)
Doctors say they were bullied by managers trying to identify whistleblower
Authors: Clare Dyer
Journal: BMJ (2020)

A hospital trust fingerprinted staff and asked for samples of their handwriting after the family of a woman who died following surgery received an anonymous letter highlighting mistakes in her care.

The whistleblower’s letter, which alleged that “something had gone wrong during surgery,” prompted the coroner examining Susan Warby’s death to instruct Sussex Police and West Suffolk NHS Foundation Trust to investigate.

Doctors accused managers of using “bullying and intimidatory” tactics in their attempt to discover the whistleblower’s identity. The letter alleged that glucose instead of saline had been mistakenly used in a drip into one of Warby’s arteries. She died, aged 57, …
Is there a place for intra-articular corticosteroid injections in the treatment of knee osteoarthritis?
Authors: John W Orchard
Journal: BMJ (2020)

### What you need to know

The prevalence of end-stage knee osteoarthritis requiring joint replacement is increasing globally.1 Some of this increase is due to increasing obesity and worsening lifestyle factors such as poor physical activity. It also requires us to evaluate whether standard treatments for mild to moderate osteoarthritis are effective.

Intra-articular corticosteroid, also referred to as corticosteroid injection, is widely prescribed for osteoarthritis of the knee. Guidelines, such as those produced by the National Institute for Health and Care Excellence (NICE),2 have traditionally supported its use,3 but reviews of efficacy indicate a high degree of uncertainty.45 On average, a patient might have symptomatic knee osteoarthritis for 30 years. It is uncertain how the long term safety or harms of corticosteroid injection balance against the likelihood of short term pain improvement.

Systematic reviews indicate low quality evidence that intra-articular corticosteroid injections may provide short term pain relief and a small improvement in physical function for up to six weeks in knee osteoarthritis compared with placebo.46 Patients with more severe disease are likely to experience greater improvement.7 The benefits are not seen to last beyond three months in trials,4 although individual patients may report longer periods of symptom relief. There is considerable heterogeneity between trials. While corticosteroid injections have been found to be safe in …
Tocilizumab can Enhance the Anti-Tumor Effect of IFN-α in Renal Cell Carcinoma
Authors: T. Oguro, K. Ishibashi, T. Sugino, S. Kumagai, N. Takahashi, N. Haga, T. Yanagida, K. Aikawa, O. Yamaguchi, Y. Kojima
Journal: Annals of Oncology (2012)
Intrathecal Trastuzumab in the Treatment of Leptomeningeal Metastases from Her2-Positive Cancer
Authors: D. Machado, M. Oliveira, S. Esteves, T. Marques, A. Clara, M. Brito, J. Freire, J. Bravo Marques, A. Moreira
Journal: Annals of Oncology (2012)
Genetic Basis of De Novo Appearance of Carotenoid Ornamentation in Bare Parts of Canaries
Authors: Małgorzata Anna Gazda, Matthew B Toomey, Pedro M Araújo, Ricardo J Lopes, Sandra Afonso, Connie A Myers, Kyla Serres, Philip D Kiser, Geoffrey E Hill, Joseph C Corbo, Miguel Carneiro
Journal: Molecular Biology and Evolution (2020)

Abstract Unlike wild and domestic canaries (Serinus canaria), or any of the three dozen species of finches in genus Serinus, the domestic urucum breed of canaries exhibits bright red bills and legs. This novel trait offers a unique opportunity to understand the mechanisms of bare-part coloration in birds. To identify the mutation producing the colorful phenotype, we resequenced the genome of urucum canaries and performed a range of analyses to search for genotype-to-phenotype associations across the genome. We identified a nonsynonymous mutation in the gene BCO2 (beta-carotene oxygenase 2, also known as BCDO2), an enzyme involved in the cleavage and breakdown of full-length carotenoids into short apocarotenoids. Protein structural models and in vitro functional assays indicate that the urucum mutation abrogates the carotenoid-cleavage activity of BCO2. Consistent with the predicted loss of carotenoid-cleavage activity, urucum canaries tended to have increased levels of full-length carotenoid pigments in bill tissue and reduced levels of carotenoid-cleavage products (apocarotenoids) in retinal tissue compared with other breeds of canaries. We hypothesize that carotenoid-based bare-part coloration might be readily gained, modified, or lost through simple switches in the enzymatic activity or regulation of BCO2 and this gene may be an important mediator in the evolution of bare-part coloration among bird species.
CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis
Authors: Lu Wang, Zibo Zhao, Mark B. Meyer, Sandeep Saha, Menggang Yu, Ailan Guo, Kari B. Wisinski, Wei Huang, Weibo Cai, J. Wesley Pike, Ming Yuan, Paul Ahlquist, Wei Xu
Journal: Cancer Cell (2016)
Corrigendum to “An injectable collagen-genipin-carbon dot hydrogel combined with photodynamic therapy to enhance chondrogenesis” [Biomaterials 218 (2019) 119190]
Authors: Zhenhui Lu, Sijia Liu, Yiguan Le, Zainen Qin, Mingwei He, Fuben Xu, Ye Zhu, Jinmin Zhao, Chuanbin Mao, Li Zheng
Journal: Biomaterials (2020)
Retrospective Study of Radiological Findings of Pulmonary Embolisms (PE) in Patients (PTS) with Advanced Non-Small Cell Lung Cancer (NSCLC)
Authors: E. Capelletto, S. Novello, F. Solitro, L. Focaraccio, M. Giaj Levra, S.G. Rapetti, T. Vavala, J. Menis, A. Veltri, G.V. Scagliotti
Journal: Annals of Oncology (2012)
Peter Betts: saved many normal short children from unnecessary growth hormone treatment
Authors: Tim Betts, Alan Craft
Journal: BMJ (2020)

Peter Betts undertook his paediatric training in Birmingham at a time when the many current subspecialties were beginning to develop. He was drawn to endocrinology and in 1978 was appointed consultant in Winchester and Southampton; he moved to Southampton full time in 1989. 

For children who were found to be short with growth hormone deficiency, human growth hormone was available to restore them to normal height, but very strict criteria had been developed to make sure this precious resource was properly used. The advent of synthetic growth hormone led to the possibility that constitutionally short (that is, short, normal) children might be made taller. At the time it was thought that short children were at a social and educational disadvantage, based on the presumption that being short was detrimental to a child’s development and, in particular, that personality and psychological functioning were adversely affected. If this were true, then almost 3% of a normal population would be under the third centile for height and potentially might be helped to achieve greater height by regular injections of growth hormone during their childhood and teenage years. Betts …
The Number of Signaling Pathways Altered by Driver Mutations in Chronic Lymphocytic Leukemia Impacts Disease Outcome
Authors: Christian Brieghel, Caspar da Cunha-Bang, Christina Westmose Yde, Ane Yde Schmidt, Savvas Kinalis, Ferran Nadeu, Michael Asger Andersen, Line Offenbach Jacobsen, Mette Klarskov Andersen, Lone Bredo Pedersen, Julio Delgado, Tycho Baumann, Mattias Mattsson, Larry Mansouri, Richard Rosenquist, Elias Campo, Finn Cilius Nielsen, Carsten Utoft Niemann
Journal: Clinical Cancer Research (2020)

Investigation of signaling pathways altered by recurrent gene mutations and their clinical impact in a consecutive cohort of patients with newly diagnosed chronic lymphocytic leukemia (CLL). The heterogeneous clinical course and genetic complexity of CLL warrant improved molecular prognostication. However, the prognostic value of recurrent mutations at the time of diagnosis remains unclear.We sequenced samples from 314 consecutive, newly diagnosed patients with CLL to investigate the clinical impact of 56 recurrently mutated genes assessed by next-generation sequencing.Mutations were identified in 70% of patients with enrichment among IGHV unmutated cases. With 6.5 years of follow-up, 15 mutated genes investigated at the time of diagnosis demonstrated significant impact on time to first treatment (TTFT). Carrying driver mutations was associated with shorter TTFT and poor overall survival. For outcome from CLL diagnosis, the number of signaling pathways altered by driver mutations stratified patients better than the number of driver mutations. Moreover, we demonstrated gradual impact on TTFT with increasing number of altered pathways independent of CLL-IPI risk. Thus, a 25-gene, pathway-based biomarker assessing recurrent mutations refines prognostication in CLL, in particular for CLL-IPI low- and intermediate-risk patients. External validation emphasized that a broad gene panel including low burden mutations was key for the biomarker based on altered pathways.We propose to include the number of pathways altered by driver mutations as a biomarker together with CLL-IPI in prospective studies of CLL from time of diagnosis for incorporation into clinical care and personalized follow-up and treatment.
Inequal benefits from regionalization of cancer care: The pancreatic cancer surgery paradigm.
Authors: Theodore P. McDade, Jillian K Smith, Zeling Chau, Elan R. Witkowski, James K. West, Jennifer F. Tseng
Journal: Journal of Clinical Oncology (2012)

4059 Background: Regionalization has been proposed for high-level care, including multidisciplinary cancer treatment and complex procedures. Pancreatic resections can serve as a marker for both. Using Massachusetts Division of Health Care Finance and Policy (DHCFP) data, we investigated regionalization of surgery for pancreatic cancer (PCa), its potential effect on perioperative outcomes, and disparities in access to high-volume PCa surgery centers. Methods: Using MA DHCFP Hospital Inpatient Discharge Data, 2005-2009, 10,524 discharges for PCa were identified, of which 746 were associated with pancreatic resection. Discharges with missing or out-of-state residence were excluded (n=704). Using geodetic methods and ZIP codes, center-to-center distances were calculated between patient (pt) and treating hospital. Median ZIP income was estimated from 2009 census data. High volume hospitals (4 of 25 performing pancreatic resections in MA) were defined using Leapfrog Criteria (&gt; 11 per year (87 th percentile for MA). Chi-square and logistic regression analyses were performed using SAS software. Results: Median age was 65. Pts were predominantly White (87.2%), with median ZIP income of $54,677. Pts travelled in-state up to 112 miles (median 15.4), with the majority resected at high volume hospitals (76%). Median length of stay (LOS) was 8.0 days, with LOS&gt;1 week associated with low volume hospitals (p=0.0002). Of 14 in-hospital deaths, 7 were at low volume hospitals (4.14% of 169 pts) compared to 7 at high volume hospitals (1.31% of 535 pts) (p=0.0214). Predictors of shorter travel distance were: Black race (OR 4.45 (95% CI 1.66-11.93)), operation at low volume hospital (OR 2.62 (95% CI 1.81-3.77), and increased age (per year) (OR 1.02 (95% CI 1.00-1.03), but not sex or median income. Conclusions: Using MA statewide discharge data, regionalization of pancreatic cancer surgery to high-volume, better-outcome centers is seen to be occurring. However, it is not uniform, and disparities exist between groups of cancer pts that do and do not travel for their care. In the current era of scrutiny on cost, quality, and access to cancer care, further study into predictors of pts receiving optimal care is warranted.
A Phase 2 Randomized Study of Ramucirumab (IMC 1121B; RAM) with or Without Dacarbazine (DTIC) in Patients (PTS) with Metastatic Melanoma (MM) (CP12-0604/NCT00533702)
Authors: R. Carvajal, J. Thompson, M. Gordon, K. Lewis, A. Pavlick, J. Wolchok, P. Rojas, J. Schwartz, A. Bedikian
Journal: Annals of Oncology (2012)
MYC Instructs and Maintains Pancreatic Adenocarcinoma Phenotype
Authors: Nicole M. Sodir, Roderik M. Kortlever, Valentin J.A. Barthet, Tania Campos, Luca Pellegrinet, Steven Kupczak, Panayiotis Anastasiou, Lamorna Brown Swigart, Laura Soucek, Mark J. Arends, Trevor D. Littlewood, Gerard I. Evan
Journal: Cancer Discovery (2020)

Abstract The signature features of pancreatic ductal adenocarcinoma (PDAC) are its fibroinflammatory stroma, poor immune activity, and dismal prognosis. We show that acute activation of Myc in indolent pancreatic intraepithelial neoplasm (PanIN) epithelial cells in vivo is, alone, sufficient to trigger immediate release of instructive signals that together coordinate changes in multiple stromal and immune-cell types and drive transition to pancreatic adenocarcinomas that share all the characteristic stromal features of their spontaneous human counterpart. We also demonstrate that this Myc-driven PDAC switch is completely and immediately reversible: Myc deactivation/inhibition triggers meticulous disassembly of advanced PDAC tumor and stroma and concomitant death of tumor cells. Hence, both the formation and deconstruction of the complex PDAC phenotype are continuously dependent on a single, reversible Myc switch. Significance: We show that Myc activation in indolent KrasG12D-induced PanIN epithelium acts as an immediate pleiotropic switch, triggering tissue-specific signals that instruct all the diverse signature stromal features of spontaneous human PDAC. Subsequent Myc deactivation or inhibition immediately triggers a program that coordinately disassembles PDAC back to PanIN. See related commentary by English and Sears, p. 495.
Ernest Herbert Jellinek
Authors: Anthony Seaton
Journal: BMJ (2020)

For generations of Edinburgh physicians, the answer to a complex neurological problem was to seek Ernest Herbert Jellinek’s opinion. The slightly alarming appearance of the black eye patch was allayed by his gentle and sympathetic approach to his patients and his efficient, detailed examination. We speculated about the eye patch but didn’t ask. On a social occasion, some years after first meeting him at the bedside of one of my patients, I learnt the story; the conversation had turned to the merits of the Isle of Man. Ernest interjected, “I was in prison there!”

Ernest was born in Vienna, the son of a distinguished medical professor who had risen from humble rural origins and was a colleague and acquaintance of Sigmund Freud. Brought up a Catholic, but with Jewish forebears, Ernest’s early education was a classical one, conducted by Benedictines at the Schottengymnasium. At the age of 12, he witnessed the gunfire associated with the killing of the prime minister and …
Promoter methylation of MGMT in paired primary and recurrent glioblastomas.
Authors: Li Bie, Ji Qing Qiu, Michael McClelland, Yan Ju
Journal: Journal of Clinical Oncology (2012)

10543 Background: Epigenetic sliencing of MGMT gene promoter in primary glioblastomas (GBM) of pts subsequently treated with temozolomide (TMZ) is associated with prolonged survival. Further, several studies have observed a change in MGMT silencing in paired primary and recurrent GBM. However, the relationship between this “MGMT switch” and patients outcome is largely unknown. Methods: The study involved primary and recurrent tumor tissue samples from 53 GBM pts diagnosed and treated within the First Hospital of Jilin University from Jan 2003 to Nov 2010. After surgical treatment, all pts were subjected to radiotherapy with concomitant administration of TMZ (75 mg/m 2 /d), followed by 5 cycles of adjuvant TMZ given at 4-weeks intervals. Pts that experienced recurrent tumors received TMZ at a dose of 200 mg/m 2 /5 days for 4 weeks. 53 pts underwent 58 further operations after recurrence (5 pts received a third surgery). MGMT promoter methylation levels were determined using qMSP. The relationship between “MGMT switch” and clinical outcome was investigated. Results: Fifty three (M/F=33/20; median age: 49.2±3.6, range: 19.5-72.3 ys) underwent a first operation for GBM. qMSP analysis revealed MGMT promoter methylation in 19 pts (35.8%, group A, OS 31.5 ms); no methylation in 34 pts (64.2%, group B, OS 7.9 ms). In the recurrent tumors, MGMT promoter methylation was detected in 25 pts (47.2%); and no methylation in 28 pts (52.8%). Comparison of individual pairs of primary and recurrent GBMs revealed a changed methylation status in 10 (18.9%), including eight changed from unmethylated to methylated tumors (15.1%, group C, OS 29.4 ms), two changed from methylated to unmethylated tumors (3.8%, group D, OS 10.5 ms). Median overall survival was 12.1 ms. MGMT promoter methylation was significantly associated with a favorable clinical outcome (group A vs group B, p=0.0027). The outcome of pts were not significant different between A and C (p&gt;0.01). Conclusions: The methylation status of the MGMT promoter was altered in 10 (18.9%) of 53 recurrent GBM after chemoradiotherapy. Eight pts changed from unmethylated to methylated who have a median overall survival similar to methylated pts. The pts changed from methylated to unmethylated who have poor outcome.
Disease-Free Survival According to Pathologic Response and P95-HER2 in the Cher-Lob Neoadjuvant Study of Chemotherapy Plus Trastuzumab, Lapatinib Or Combined Trastuzumab and Lapatinib In HER2+ Operable Breast Cancer
Authors: V. Guarneri, G. Bisagni, A. Bottini, K. Cagossi, A. Frassoldati, F. Piacentini, C. Holford, J. Bruey, R. D'Amico, P.F. Conte
Journal: Annals of Oncology (2012)
Re-Surgery for Recurrent Glioblastoma: Outcome Analisys and Correltion with Mgmt Status
Authors: A. Brandes, E. Franceschi, R. Poggi, R. Degli Esposti, M. Di Battista, L. Lombardo, F. Girardi, D. Palleschi, S. Bartolini, M. Ermani
Journal: Annals of Oncology (2012)
Clinical Outcome of Cetuximab for Metastatic Colorectal Cancer Patients Harboring Kras CODON61, Kras CODON146, Braf, Nras or PIK3CA Mutations
Authors: E. Shinozaki, H. Bando, T. Nishina, K. Yamazaki, S. Kadowaki, S. Yuki, S. Kajiura, K. Tsuchihara, S. Fujii, T. Yoshino
Journal: Annals of Oncology (2012)
A Case of Lung Adenocarcinoma with Wild-Type EGFR Malignant Pleural Effusion Well Controlled by Treatment with Gefitinib
Authors: Y. Ueda, T. Takahama, K. Sakai, H. Miyawaki, T. Yoshikawa, T. Misao, M. Aoe, N. Kanaji, T. Ishii, S. Bandoh, T. Matsunaga
Journal: Annals of Oncology (2012)
Cathodic protected Mn2+ by NaxWO3 nanorods for stable magnetic resonance imaging-guided tumor photothermal therapy
Authors: Yang Liu, Shiman Wu, Yanyan Liu, Hua Zhang, Meng Zhang, Zhongmin Tang, Yan Wang, Teng Gong, Zhenwei Yao, Xiangming Fang, Wenbo Bu
Journal: Biomaterials (2020)
Real-Time Electronic Monitoring of Patient-Reported Symptoms and Syndromes (PRS): E-Mosaic, a Multicenter Phase iii Study (Sakk 95/06)
Authors: D. Blum, D. Koeberle, R. von Moos, K. Ribi, S. Aebi, D.C. Betticher, S. Hayoz, J. Nadig, S. Mauri, F. Strasser
Journal: Annals of Oncology (2012)
Planned earlier delivery for late pre-eclampsia may be better for mothers
Authors: Rob Cook, Johnny Lyon-Maris, Peter Davidson
Journal: BMJ (2020)

The study Chappell LC, Brocklehurst P, Green ME, et al. Planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): a randomised controlled trial. Lancet 2019;394:1181-90. This project was funded by the NIHR Health Technology Assessment Programme (project number 12/25/03). To read the full NIHR Signal, go to: https://discover.dc.nihr.ac.uk/content/signal-000838/mothers-benefit-from-a-planned-earlier-delivery-for-late-pre-eclampsia