tbuckley/cabot-search huggingface dataset:
Elevated AREG/EGF Ratio Prior to Transplantation Is Associated with Pre-Transplant Clostridium Difficile Infection, Unresolved Tissue Damage, and Poorer Overall Survival
Authors: Sarah L.P. Atkins, Todd E. DeFor, Margaret L. MacMillan, Lucie Turcotte, Armin Rashidi, Daniel J. Weisdorf, Alexander Khoruts, Shernan G. Holtan
Journal: Blood (2018)
A Phase 2 Study of Actinium-225 (225Ac)-Lintuzumab in Older Patients with Untreated Acute Myeloid Leukemia (AML) - Interim Analysis of 1.5 µci/Kg/Dose
Authors: Ehab L. Atallah, Johnnie J. Orozco, Michael Craig, Moshe Yair Levy, Laura E. Finn, Sharif S. Khan, Alexander E. Perl, Jae H. Park, Gail J. Roboz, William Tse, Kebede H. Begna, Raya Mawad, David A. Rizzieri, Mark S. Berger, Joseph G. Jurcic
Journal: Blood (2018)
Group B <i>Streptococcus</i>, an A-List Pathogen in Nonpregnant Adults
Authors: Miriam Baron Barshak
Journal: JAMA Internal Medicine (2019)

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Abstract 17123: Mortality Following Electrophysiology and Cardiac Implantable Electronic Device Procedures
Authors: Justin Z Lee, Jayna Ling, Nancy N Diehl, David O Hodge, Deepak Padmanabhan, Ammar M Killu, Malini Madhavan, Peter A Noseworthy, Suraj Kapa, Christopher J McLeod, Yong-Mei Cha, Abhishek J Deshmukh, Komandoor Srivathsan, Fred M Kusumoto, Win K Shen, Paul A Friedman, Thomas M Munger, Samuel J Asirvatham, Douglas L Packer, Siva K Mulpuru
Journal: Circulation (2017)

Introduction: Real world mortality rates after arrhythmia-based procedures, which include electrophysiology (EP) and cardiac implantable electronic device (CIED) procedures, are currently unknown. ...
Compounded Topical Pain Creams to Treat Localized Chronic Pain
Authors: Robert E. Brutcher, Connie Kurihara, Mark C. Bicket, Parvaneh Moussavian-Yousefi, David E. Reece, Lisa M. Solomon, Scott R. Griffith, David E. Jamison, Steven P. Cohen
Journal: Annals of Internal Medicine (2019)

Background: The use of compounded topical pain creams has increased dramatically, yet their effectiveness has not been well evaluated. Objective: To determine the efficacy of compounded creams for chronic pain. Design: Randomized controlled trials of 3 interventions. (ClinicalTrials.gov: NCT02497066) Setting: Military treatment facility. Participants: 399 patients with localized pain classified by each patient's treating physician as neuropathic (n = 133), nociceptive (n = 133), or mixed (n = 133). Intervention: Pain creams compounded for neuropathic pain (ketamine, gabapentin, clonidine, and lidocaine), nociceptive pain (ketoprofen, baclofen, cyclobenzaprine, and lidocaine), or mixed pain (ketamine, gabapentin, diclofenac, baclofen, cyclobenzaprine, and lidocaine), or placebo. Measurements: The primary outcome measure was average pain score 1 month after treatment. A positive categorical response was a reduction in pain score of 2 or more points coupled with a score above 3 on a 5-point satisfaction scale. Secondary outcomes included Short Form-36 Health Survey scores, satisfaction, and categorical response. Participants with a positive outcome were followed through 3 months. Results: For the primary outcome, no differences were found in the mean reduction in average pain scores between the treatment and control groups for patients with neuropathic pain (−0.1 points [95% CI, −0.8 to 0.5 points]), nociceptive pain (−0.3 points [CI, −0.9 to 0.2 points]), or mixed pain (−0.3 points [CI, −0.9 to 0.2 points]), or for all patients (−0.3 points [CI, −0.6 to 0.1 points]). At 1 month, 72 participants (36%) in the treatment groups and 54 (28%) in the control group had a positive outcome (risk difference, 8% [CI, −1% to 17%]). Limitations: Generalizability is limited by heterogeneity among pain conditions and formulations of the study interventions. Randomized follow-up was only 1 month. Conclusion: Compounded pain creams were not better than placebo creams, and their higher costs compared with approved compounds should curtail routine use. Primary Funding Source: Centers for Rehabilitation Sciences Research, Defense Health Agency, U.S. Department of Defense.
Gastrointestinal Staphylococcus aureus: immune responses to its enterotoxins and regulatory T cell dysfunction in childhood food allergy
Authors: Kristin A. Erickson, Benjamin T. Prince, Sujata Saha, Christine Szychlinski, Miao Cai, Kathryn E. Hulse, Victoria Rajamanickam, Ronald E. Gangnon, Robert P. Schleimer, Paul J. Bryce, Anne Marie Singh
Journal: Journal of Allergy and Clinical Immunology (2019)
Autologous Haematopoietic Stem Cell Transplantation in Patients with Multiple Myeloma Complicated By Dialysis-Dependent Renal Failure
Authors: Maiia V. Firsova, Larisa P. Mendeleeva, Irina G. Rekhtina, Maxim V. Solovev, Olga S. Pokrovskaya, Eduard Gemdzhian, Ludmila S. Biryukova, Valery G. Savchenko
Journal: Blood (2018)
Randomized phase II/III study of 5-fluorouracil/l-leucovorin versus 5-fluorouracil/l-leucovorin plus paclitaxel in gastric cancer with severe peritoneal metastasis (JCOG1108/WJOG7312G).
Authors: Kensei Yamaguchi, Takako Eguchi Nakajima, Narikazu Boku, Ichinosuke Hyodo, Junki Mizusawa, Hiroki Hara, Tomohiro Nishina, Takeshi Sakamoto, Kohei Shitara, Katsunori Shinozaki, Hiroshi Katayama, Shinichiro Nakamura
Journal: Journal of Clinical Oncology (2019)

80 Background: Oral fluoropyrimidine plus cisplatin is a standard treatment for advanced gastric cancer, but patients (pts) with severe peritoneal metastasis (PM) often cannot tolerate it. 5-fluorouracil (F), l-leucovorin (L) and paclitaxel (P) therapy (FLTAX) showed a promising activity in a feasibility study for such pts. We conducted a phase II/III (P-II/III) study comparing FLTAX vs FL. Methods: Eligibility criteria included: unresectable or recurrent gastric adenocarcinoma; 20–75 years; performance status (PS) 0–2; PM+; massive ascites and/or inadequate oral intake; no prior chemotherapy. Pts were randomly assigned to receive FL (F 600 mg/m 2 , L 250 mg/m 2 on day1, 8, 15, 22, 29 and 36 q8w), or FLTAX (F 500 mg/m 2 , L 250 mg/m 2 , P 60 mg/m 2 on day1, 8 and 15 q4w). In the P-II, decision to proceed to the P-III was made based on the median survival time (MST) in both arms and treatment success rate at week 8 with the threshold of 30% in the FLTAX. Primary endpoint of the P-III was overall survival. Results: A total of 101 pts (51 in FL and 50 in FLTAX) were enrolled to the P-II. Because of poor accrual, the protocol was amended for termination and the final analysis for the P-III was conducted. Treatment success rate at week 8 in FLTAX was 66.7% (95% confidence interval [CI] 51.6-79.6). MST was 6.1 M and 7.3 M for FL and FLTAX, respectively (HR 0.79; 80% CI 0.60-1.05; p = 0.14). MST was 2.5 M for FL and 5.1 M for FLTAX (HR 0.59; 95% CI 0.27-1.28) in pts with PS2 (n = 27); 6.5 M and 8.6 M, respectively (HR 1.02; 95% CI 0.62-1.68) in pts with PS0/1 (n = 74). Median progression-free survival was 1.9 M for FL and 5.4 M for FLTAX (HR 0.64; 95% CI, 0.43-0.96; p = 0.029). Common adverse events of grade ≥ 3 were neutropenia (FL 30.0%, FLTAX 20.8%), and anorexia (FL 47.1%, FLTAX 31.3%). Conclusions: Although this study could not show a survival benefit of FLTAX over FL for pts with severe PM, FLTAX would be an option with longer PFS and feasible toxicity, especially for pts with PS2. Clinical trial information: UMIN000010949.
Abstract MP27: Weight Change, BMI, and Mortality Among Survivors of Myocardial Infarction: Analysis of Two Prospective US Cohort Studies
Authors: Laila Al-Shaar, Yanping Li, Eric Rimm, JoAnn E Manson, Frank Hu, Walter Willett
Journal: Circulation (2018)

Background: The relation between BMI, weight change and mortality among survivors of Myocardial Infarction (MI) remains controversial, with some studies reporting favorable survival outcomes among overweight and obese patients, as compared to those with normal weight. We aim to examine the relationship between BMI reported shortly before and after MI diagnosis in addition to weight change with all-cause and cardiovascular disease (CVD) mortality among MI survivors. Methods: Using the data from Nurses’ Health Study (NHS) and Health Professionals Follow up Study (HPFS) cohorts, we studied 4278 participants who were free of CVD and cancer before their MI. Weight change (in BMI units) was categorized as loss of (&gt; 4, 2-4, &lt;2-0 (reference)), or gain of (0.1-2, or &gt;2) units. Multivariable Cox models were used to estimate hazard ratios and 95 % confidence interval for mortality across BMI/weight change categories. Results: During up to 36 (NHS) and 28 (HPFS) years of follow-up post-MI, there were 2071 all-cause and 835 CVD deaths. Overweight patients with BMI before or after MI of 25-27.49 kg/m 2 had decreased mortality as compared to normal weight patients (22.5-24.9 kg/m 2 ). All-cause mortality increased progressively with higher BMI. Obese patients (BMI≥30) had the highest risk of CVD mortality (HR=1.35; 95% CI, 1.06-1.73). Among MI patients who had never smoked (N=1484) or were younger than 65 years of age at the time of diagnosis (N=1873), no survival advantage was observed for overweight/obese patients. Compared to stable weight (a BMI reduction of 0-1.99 units) from before to after MI, a reduction of 2-4 or &gt;4 BMI units was associated with increased mortality (HR=1.12; 95% CI, 0.96-1.29 and 1.42; 95% CI, 1.17-1.71 respectively, Figure). Conclusions: We observed a J-shaped association between BMI and mortality among all MI patients, but not among those who had never smoked or were younger than 65 years of age. Weight loss associated with acute MI, potentially related to disease severity, is an important predictor of higher mortality.
Serum levels of TARC, MDC, IL-10, and soluble CD163 in Hodgkin lymphoma: a SWOG S0816 correlative study
Authors: Eric D. Hsi, Hongli Li, Andrew B. Nixon, Heiko Schöder, Nancy L. Bartlett, Michael LeBlanc, Sonali Smith, Brad S. Kahl, John P. Leonard, Andrew M. Evens, David W. Scott, Lisa M. Rimsza, Jonathan W. Friedberg
Journal: Blood (2019)
Outcomes of Salvage Haploidentical Transplant with Post-Transplant Cyclophosphamide for Rescuing Primary Graft Failure Patients : A Report By the SFGM-TC
Authors: Pedro H Prata, Matthieu Resche-Rigon, Didier Blaise, Gérard Socié, Pierre Simon Rohrlich, Noel-Jean Milpied, Pascal Turlure, Stephanie Nguyen, Anne Sirvent, Claude-Eric Bulabois, Eric Deconinck, Amandine Charbonnier, Patrice Chevallier, Jacques-Olivier Bay, Benedicte Neven, Charlotte Jubert, Mohamad Mohty, Marie Thérèse Rubio, Regis Peffault De Latour
Journal: Blood (2018)
Inhibition of Semaphorin 3A Signaling Promotes Regeneration of Hematopoietic Stem Cells and Their Bone Marrow Vascular Niche
Authors: John P Chute, Christina Termini, Lauren Schlussel, Martina M Roos, Jenny Kan, Joshua Sasine, Tiancheng Fang, Heather A Himburg
Journal: Blood (2018)
Infographic. Walking on sunshine: scoping review of the evidence for walking and mental health
Authors: Paul Kelly, Chloë Williamson, Ruth Hunter, Ailsa G Niven, Nanette Mutrie, Justin Richards
Journal: British Journal of Sports Medicine (2019)

The link between physical activity and better mental health is well established.1 2 However, substantially less is known about the relationships between walking and mental health.3 Morris and Hardman identified this gap in their seminal ‘Walking to Health’ paper in 1997 and stated that ‘The pleasurable and therapeutic, psychological and social dimensions of walking, whilst evident, have been surprisingly little studied’.4 

Walking is an accessible, population-level behaviour conducted by persons of all ages and sexes, and as such one with great public health potential.5 …
Mother nature: how a hospital garden is nourishing pregnant women in Zimbabwe
Authors: Jacqui Thornton
Journal: BMJ (2019)

Jordi Matas/British Red Cross

The mother to be Nation Mugwadi (in brown dress) examines the vegetables that continue to grow despite the blazing Zimbabwean sunshine. It’s 37°C and she’s three weeks from term, but she is happy to help out in the “nutrition garden” at Mwenezi District Hospital, where she is due to give birth.

Mugwadi and her fellow volunteers are part of a project to improve the diet of pregnant and lactating women. They grow spinach, butternut squash, maize, and more, which they eat during their stay in hospital. Previously they had to bring in their …
Dysregulation of RUNX3 in Aged Human HSPCs May Contribute to Perturbations in Erythropoiesis and Balanced Lineage Output
Authors: Peter Balogh, Brian Capaldo, Sandeep Singh, Kamaleldin Elagib, Hui Li, Eli Zunder, Maria E. Figueroa, Wendy Pang, Adam Goldfarb
Journal: Blood (2018)
Association Between Severe Serum Alanine Aminotransferase Flares and Hepatitis B e Antigen Seroconversion and HBV DNA Decrease in Untreated Patients With Chronic HBV Infection
Authors: Mayur Brahmania, Manuel Lombardero, Bettina E. Hansen, Norah A. Terrault, Anna S. Lok, Robert P. Perrillo, Steven H. Belle, Adrian M. Di Bisceglie, Jordan J. Feld, William M. Lee, Michael W. Fried, Harry L.A. Janssen, Daryl T-Y. Lau, Raymond T. Chung, Lewis R. Roberts, Mohamed A. Hassan, Mauricio Lisker-Melman, David K. Wong, Joshua Juan, Colina Yim, Keyur Patel, Carol S. Murakami, Son Do, Steven-Huy B. Han, Tram T. Tran, Mandana Khalili, Stewart L. Cooper, Robert J. Fontana, Naoky Tsai, Barak Younoszai, Andrew Muir, Donna Evon, Jama M. Darling, Robert C. Carithers, Margaret Shuhart, Kris V. Kowdley, Chia C. Wang, Richard K. Sterling, Marc G. Ghany, T. Jake Liang, Jay H. Hoofnagle, Edward Doo, Kyong-Mi Chang, Jang-June Park, Abdus Wahed, Yona Cloonan, David Kleiner
Journal: Clinical Gastroenterology and Hepatology (2019)
Response to: 'Is it time to redefine the role of low-dose radiotherapy for benign disease?' by Montero <i>et al</i>
Authors: Elien A M Mahler, Michiel JM Minten, Mathilde M Leseman-Hoogenboom, Philip M P Poortmans, Jan Willem Leer, Simone S Boks, Frank H J van den Hoogen, Alfons A den Broeder, Cornelia H van den Ende
Journal: Annals of the Rheumatic Diseases (2019)

We thank the authors, with affiliations of six departments of radiation oncology in Spain and Germany, for their interest in our randomised controlled trials (RCT) and their compliments on the study designs.1 Our studies showed no substantial beneficial effect on symptoms of low-dose radiation therapy (LDRT) in patients with knee and hand osteoarthritis (OA).2 3 These findings dispute the effectiveness of radiation therapy at low doses in OA as commonly used in certain parts of the world. However, the authors mention several aspects, which should be taken into account when definitively appreciating our results, which we like to reply on in this letter.

We agree that OA is a serious health problem considering its high clinical burden, the high and rising prevalence, and the growing impact on healthcare and future economic costs.4 Subsequently, there is a clear need to improve management of OA that is supported by scientific evidence, as no effective disease-modifying treatments are available. Therefore, current treatment focuses primarily on the reduction of symptoms including pain and loss of function while the importance and efficacy of non-surgical treatment modalities have been described in several international clinical guidelines for the management of knee and hand OA.5 6 Of note, the authors mention approaches (ie, local heat, magnetic therapy and shock wave) not supported by evidence or included in international guidelines for the management of OA.

The authors state that the analgesic effect of radiation therapy is smaller in OA than other osteoarticular disorders (eg, calcaneodynia, achillodynia, bursitis trochanterica). This statement is based on findings of two observational studies with heterogeneous populations using a single transition question (von Pannewitz scale) that is likely to be biased by social desirability, in particular when assessed by telephone. The inferior design of those studies does not allow evidence-based discrimination …
Lipid-Lowering Agents
Authors: Robert A. Hegele, Sotirios Tsimikas
Journal: Circulation Research (2019)

Several new or emerging drugs for dyslipidemia owe their existence, in part, to human genetic evidence, such as observations in families with rare genetic disorders or in Mendelian randomization studies. Much effort has been directed to agents that reduce LDL (low-density lipoprotein) cholesterol, triglyceride, and Lp[a] (lipoprotein[a]), with some sustained programs on agents to raise HDL (high-density lipoprotein) cholesterol. Lomitapide, mipomersen, AAV8.TBG.hLDLR, inclisiran, bempedoic acid, and gemcabene primarily target LDL cholesterol. Alipogene tiparvovec, pradigastat, and volanesorsen primarily target elevated triglycerides, whereas evinacumab and IONIS-ANGPTL3-LRx target both LDL cholesterol and triglyceride. IONIS-APO(a)-LRx targets Lp(a).
Abstract 72: Chest X-ray as an Additional Diagnostic Tool in Kawasaki Disease
Authors: Najib Advani, Lucyana Alim Santoso
Journal: Circulation (2015)

Background: Diagnosis of Kawasaki disease (KD) is sometimes doubtful. Chest x-ray examination is easily available and relatively not expensive. However, its role in the diagnosis of Kawasaki disease according to some studies, is not significant.So far we have no data from Indonesia. Objective: To know the chest x-ray patterns in acute KD patients. Methods: We studied chest x-ray films of KD children at acute stage from January 2003 till July 2013 which were taken consecutively in 5 hospitals. All cases were treated by the author. All films were seen and confirmed by radiologists. Results: We analyzed chest x-ray films (antero-posterior view) of 503 KD patients at acute stage, age ranging from 33 days to 16 years. The results were that 335 (67%) of them showed abnormalities, of which almost all showed infiltrates in bilateral lung fields especially in perihillar and paracardial regions. Only one case showed lobar pneumonia pattern and another with pleural effusion. Only 31 (10.8%) patients with chest x-ray abnormalities clinically showed respiratory signs and symptoms such as cough and running nose. Conclusion: It is concluded that the presence of pulmonary infiltrates in chest x-ray may be of value in supporting the diagnosis of KD, especially in doubtful or incomplete cases.
Abstract 11699: Presence of Inconsistently Graded Severe Aortic Valve Stenosis Despite Pressure Recovery Adjustment Predicts Impaired Outcome
Authors: Edda B Bahlmann, Dana Cramariuc, Sahrai Saeed, Terje Pedersen, Nikolaus Jander, Jan Minners, John B Chambers, Karl Heinz Kuck, Eva Gerdts
Journal: Circulation (2017)

Introduction: Conflicting evidence exists on the prognostic impact of inconsistently graded aortic valve stenosis (AS) in asymptomatic patients. Pressure recovery adjustment of aortic valve area (energy loss, EL) is recommended for more accurate grading, but the outcome in asymptomatic patients with inconsistently graded severe AS defined from combined EL ≤1cm2 and mean aortic gradient ≤40mmHg has not been reported. Hypothesis: Inconsistently graded severe AS identified by EL and mean gradient is associated with impaired outcome. Methods: Data from 1497 patients with initially asymptomatic mild-moderate AS and normal ejection fraction enrolled in the Simvastatin and Ezetimibe in Aortic Stenosis study was used. Median follow-up was 4.3 years. 25 patients with consistently graded severe AS at baseline were excluded, and included patients were grouped according to presence of consistently graded non-severe AS or inconsistently graded severe AS. Outcome was assessed in Cox regression analysis and reported as ...
Abstract 12779: Increased Diastolic Untwisting Velocity in Response to Tachycardia as Evidence of Diastolic Reserve in the Young Infant Heart: A Simultaneous Invasive and Noninvasive in vivo Swine Model
Authors: Etienne Fortin-Pellerin, Lindsay Mills, James Y Coe, Nee S Khoo, Po Y Cheung, Lisa K Hornberger
Journal: Circulation (2014)

Introduction: In response to exercise, the healthy adult left ventricle (LV) augments its filling through early untwisting, creating suction even before the AV valve opens. The role of untwisting i...
Psychosocial Evaluation in Allogeneic Hematopoietic Cell Transplantation Recipients (Allo HCT): Psychosocial Assessment of Candidates for Transplant (PACT) As a Tool to Identify High-Risk Patients and Its Association with Transplant Outcomes
Authors: Sanghee Hong, Lisa Rybicki, Jane Dabney, Christine Lawrence, Betty K. Hamilton, Matt Kalaycio, Linda McLellan, Ronald Sobecks, Stephanie J. Lee, Navneet S. Majhail
Journal: Blood (2018)
Procalcitonin As a Potential Biomarker for Differentiating Bacterial Infectious Fevers from Cytokine Release Syndrome
Authors: Joseph Maakaron, Sam Penza, Zeinab El Boghdadly, Caron A. Jacobson, Bradley Hunter, Matthew J. Frigault, Jeremy S. Abramson, Justin Kline, Jonathon B. Cohen, Ajay K. Gopal, Utkarsh H. Acharya, Samantha Jaglowski, Philippe Armand
Journal: Blood (2018)