Treatment of Severe Malaria in the United States
Authors: Emilia M. Sordillo, Melissa Gitman, Michael D. Nowak, Alberto E. Paniz Mondolfi
Journal: Annals of Internal Medicine (2020)

Letters4 February 2020Treatment of Severe Malaria in the United StatesEmilia M. Sordillo, MD, PhD, Melissa Gitman, MD, MPH, Michael D. Nowak, MD, and Alberto E. Paniz Mondolfi, MD, PhDEmilia M. Sordillo, MD, PhDIcahn School of Medicine at Mount Sinai, New York, New York (E.M.S., M.G., M.D.N., A.E.P.)Search for more papers by this author, Melissa Gitman, MD, MPHIcahn School of Medicine at Mount Sinai, New York, New York (E.M.S., M.G., M.D.N., A.E.P.)Search for more papers by this author, Michael D. Nowak, MDIcahn School of Medicine at Mount Sinai, New York, New York (E.M.S., M.G., M.D.N., A.E.P.)Search for more papers by this author, and Alberto E. Paniz Mondolfi, MD, PhDIcahn School of Medicine at Mount Sinai, New York, New York (E.M.S., M.G., M.D.N., A.E.P.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L19-0675 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We strongly agree with Krey and Travassos (1) that hospitals throughout the United States may face difficulties in providing timely, effective therapy for complicated malaria now that Eli Lilly has discontinued production of quinidine gluconate, the only FDA-approved treatment for severe malaria. Data from the CDC (2) indicate that hospitals in every state may encounter a patient with severe malaria. Most of the 2078 malaria cases (68.2% involving infection with Plasmodium falciparum) reported during 2016 were from New York City (265 cases) and 14 other jurisdictions that each reported more than 50 cases; however, all 50 states ...References1. Krey RA, Travassos MA. Severe malaria treatment in the United States at the precipice. Ann Intern Med. 2019;171:362-3. [PMID: 31426092]. doi:10.7326/M19-1144 LinkGoogle Scholar2. Mace KE, Arguin PM, Lucchi NW, et al. Malaria surveillance—United States, 2016. MMWR Surveill Summ. 2019;68:1-35. [PMID: 31099769] doi:10.15585/mmwr.ss6805a1 CrossrefMedlineGoogle Scholar3. Conn JE, Grillet ME, Correa M, et al. Malaria transmission in South America—present status and prospects for elimination. In: Manguin S, Dev V, eds. Towards Malaria Elimination—A Leap Forward. IntechOpen. 2018. doi:10.5772/intechopen.76964 Google Scholar4. Grillet ME, Hernández-Villena JV, Llewellyn MS, et al. Venezuela's humanitarian crisis, resurgence of vector-borne diseases, and implications for spillover in the region. Lancet Infect Dis. 2019;19:e149-61. [PMID: 30799251] doi:10.1016/S1473-3099(18)30757-6 CrossrefMedlineGoogle Scholar5. Menard D, Dondorp A. Antimalarial drug resistance: a threat to malaria elimination. Cold Spring Harb Perspect Med. 2017;7. [PMID: 28289248] doi:10.1101/cshperspect.a025619 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Icahn School of Medicine at Mount Sinai, New York, New York (E.M.S., M.G., M.D.N., A.E.P.)Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L19-0675. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSevere Malaria Treatment in the United States at the Precipice Rebecca A. Krey and Mark A. Travassos Treatment of Severe Malaria in the United States Chandy C. John Metrics 4 February 2020Volume 172, Issue 3Page: 225KeywordsAntimalarialsArtesunateBloodChloroquineConflicts of interestDisclosureMalariaMultidrug resistanceParasitemiaPlasmodium falciparum ePublished: 4 February 2020 Issue Published: 4 February 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...