tbuckley/cabot-search huggingface dataset:
False-Positive 18F-PSMA-1007 and True-Negative 18F-Fluorocholine PET/CT Splenic Hemangioma
Authors: Emmanouil Panagiotidis, Anna Paschali, Xanthi Xourgia, Vassiliki Chatzipavlidou
Journal: Clinical Nuclear Medicine (2020)

Abstract A 62-year-old man with prostate cancer underwent both 18 F-PSMA-1007 and 18 F-fluorocholine PET/CT studies for biochemical recurrence. 18 F-PSMA-1007 PET/CT outperformed 18 F-fluorocholine PET/CT in detecting lymph node metastases in the pelvis and retroperitoneum, whereas the former showed a focus of increased uptake in the spleen not seen on 18 F-fluorocholine. The 18 F-PSMA-1007 –avid lesion corresponded to a splenic hemangioma, which was initially detected in an MRI scan 10 years ago, unchanged in size. This case shows different features of 18 F-PSMA-1007 and 18 F-fluorocholine uptake, in an incidentally detected splenic hemangioma, alerting PET/CT reports for possible pitfall.
SAT0133 Predictors of pain and its change over time in fibromyalgia
Authors: PH Dessein, AE Stanwix, Z Moomal
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> Widespread pain is the central feature of fibromyalgia (FM). The role of physical as opposed to psychological mechanisms in FM pain remains a matter of controversy. <h3>Objectives</h3> In the present study, we evaluated the dependency of FM pain on other FM clinical features as assessed by the Fibromyalgia Impact Questionnaire (FIQ). <h3>Methods</h3> Forty two consecutive patients, who had been followed up for at least 2 months, were enrolled. Their mean (SD, range) age, disease duration and follow up duration were 42 (12, 15–78), 8 (11, 0.3–45) and 2.9 (2.2, 0.28 -8.6) years, respectively. They completed FIQ scores as applied to their health status at enrolment in the clinic and at the time of the study. Statistical analyses were done by simple linear regression analyses and one-way analysis of variance. Results were expressed as mean (SD) and a p &lt; 0.05 was considered significant. <h3>Results</h3> The pain visual analogue scale was 8.9 (1.3) at enrolment versus 2.4 (1.9) at the time of the study (p &lt; 0.001). At enrolment, pain was predicted by morning tiredness (p &lt; 0.001), FM symptom interference with work (p &lt; 0.001) and stiffness (p = 0.001). At the time of the study, pain was predicted by tiredness (p &lt; 0.001), morning tiredness (p &lt; 0.001), FM symptom interference with work (p = 0.003) and stiffness (p = 0.03). Improvement in pain was predicted by pain at enrolment (p = 0.007) (and by no other baseline FIQ scores) and improvements in tiredness (p &lt; 0.001), morning tiredness (p &lt; 0.001), FM symptom interference with work (p &lt; 0.001) and stiffness (p = 0.002). <h3>Conclusion</h3> Pain and fatigue were strongly interrelated in our FM patients. The physical symptoms fatigue, stiffness and FM symptom interference with work consistently predicted FM pain and its change over time. In contrast, the psychological variables anxiety and depression, as assessed by the FIQ, did not relate to FM pain. <h3>References</h3> Goldenberg DL. Arch Intern Med. 1999;<b>159</b>:777–85 Dessein PH, <i>et al</i>. Pain Rev. 1997;4:79–88 Burckhardt CS, <i>et al</i>. J Rheumatol. 1991;18:728–37
Avoiding Cognitive Errors in Clinical Decision Making
Authors: Daniel M. Musher
Journal: Annals of Internal Medicine (2020)

Letters20 October 2020Avoiding Cognitive Errors in Clinical Decision MakingDaniel M. Musher, MDDaniel M. Musher, MDBaylor College of Medicine and Michael E. DeBakey VA Medical Center, Houston, Texas (D.M.M.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L20-1058 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I would like to add a further point to Restrepo and colleagues' (1) excellent article on avoiding cognitive errors in clinical decision making. The word diagnosis has always been problematic to me as a clinician and teacher. It sounds so absolute, so … definite. What we call a diagnosis is actually a hypothesis—a theory that we advance in an attempt to explain a set of facts but that is fluid and alterable as additional facts are adduced.A perfect example of this is Case 2 in Restrepo and colleagues' article. A 100–pack-year cigarette smoker presented with subacute ...Reference1. Restrepo D, Armstrong KA, Metlay JP. Annals clinical decision making: avoiding cognitive errors in clinical decision making. Ann Intern Med. 2020;172:747-51. [PMID: 32311734]. doi:10.7326/M19-3692 LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Baylor College of Medicine and Michael E. DeBakey VA Medical Center, Houston, Texas (D.M.M.)Disclosures: The author has disclosed no conflicts of interest. The form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L20-1058. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAnnals Clinical Decision Making: Avoiding Cognitive Errors in Clinical Decision Making Daniel Restrepo , Katrina A. Armstrong , and Joshua P. Metlay Avoiding Cognitive Errors in Clinical Decision Making Robert L. Trowbridge , Joseph J. Rencic , Thilan P. Wijesekera , and Andrew P.J. Olson Avoiding Cognitive Errors in Clinical Decision Making Daniel Restrepo , Katrina A. Armstrong , and Joshua P. Metlay Metrics 20 October 2020Volume 173, Issue 8Page: 679KeywordsChronic bronchitisChronic obstructive pulmonary diseaseDecision makingDyspneaEmphysemaIschemiaLungsOxygenPulmonary functionReasoning ePublished: 20 October 2020 Issue Published: 20 October 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Higher mortality of COVID-19 in males: sex differences in immune response and cardiovascular comorbidities
Authors: Laura A Bienvenu, Jonathan Noonan, Xiaowei Wang, Karlheinz Peter
Journal: Cardiovascular Research (2020)

The high mortality rate of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is a critical concern of the coronavirus disease 2019 (COVID-19) pandemic. Strikingly, men account for the majority of COVID-19 deaths, with current figures ranging from 59% to 75% of total mortality. However, despite clear implications in relation to COVID-19 mortality, most research has not considered sex as a critical factor in data analysis. Here, we highlight fundamental biological differences that exist between males and females, and how these may make significant contributions to the male-biased COVID-19 mortality. We present preclinical evidence identifying the influence of biological sex on the expression and regulation of angiotensin-converting enzyme 2 (ACE2), which is the main receptor used by SARS-CoV-2 to enter cells. However, we note that there is a lack of reports showing that sexual dimorphism of ACE2 expression exists and is of functional relevance in humans. In contrast, there is strong evidence, especially in the context of viral infections, that sexual dimorphism plays a central role in the genetic and hormonal regulation of immune responses, both of the innate and the adaptive immune system. We review evidence supporting that ineffective anti-SARS-CoV-2 responses, coupled with a predisposition for inappropriate hyperinflammatory responses, could provide a biological explanation for the male bias in COVID-19 mortality. A prominent finding in COVID-19 is the increased risk of death with pre-existing cardiovascular comorbidities, such as hypertension, obesity, and age. We contextualize how important features of sexual dimorphism and inflammation in COVID-19 may exhibit a reciprocal relationship with comorbidities, and explain their increased mortality risk. Ultimately, we demonstrate that biological sex is a fundamental variable of critical relevance to our mechanistic understanding of SARS-CoV-2 infection and the pursuit of effective COVID-19 preventative and therapeutic strategies.
Response to: ‘Role of interaction between B cells and epithelial cells in pSS’ by Pringle et al
Authors: Elodie Rivière, Xavier Mariette, Gaetane Nocturne
Journal: Annals of the Rheumatic Diseases (2020)

We thank Pringle et al for their interest and their comments1 concerning our recent article demonstrating how salivary gland epithelial cells (SGECs) from patients with primary Sjogren’s syndrome (pSS) can induce survival and activation of B cells.2 They are rising six very interesting questions:

(1) F Kroese’s group has extensively studied B cells expressing FcRL4 in pSS.3 4 They have shown that this B cell subset is highly proliferating, express activation markers and participates to the formation of lymphoepithelial lesions. Interestingly, they have shown that FcRL4 mRNA was increased in parotid from patients with pSS with mucosa-associaed lymphoid tissue (MALT) lymphoma. FcRL4 could promote innate signalling in response to chronic antigenic stimulation. For all these reasons, it is tempting to speculate that FcRL4+ B cells could be involved in the crosstalk with SGECs.5 We looked at FcRL4 expression in our RNA-seq data set (figure 1A). We did not detect FcRL4 mRNA in blood, nor in salivary gland biopsy. This could …
40P Correlation of IL-1-β-serum concentration with the number of leukocytes in peripheral blood in patients with solid tumours before immune checkpoint inhibitors therapy
Authors: A.M. Malkova, R.V. Orlova, N.V. Zhukova, V.V. Sharoyko, E.A. Kaledina, A. Gubal
Journal: Annals of Oncology (2020)
Health Policy in a Biden Administration
Authors: Sherry Glied
Journal: New England Journal of Medicine (2020)

Interview with Drs. Sherry Glied and Mark Pauly on what U.S. health policy could look like in the coming years under a Biden or a Trump administration. (18:12)Download A Biden administration would aim to address today's critical challenges — Covid-19, gaps in health insurance coverage, high costs, and inadequate care for the disabled — by means of actionable reforms aimed at the most vulnerable Americans.
Long Noncoding RNA TINCR-Mediated Regulation of Acetyl-CoA Metabolism Promotes Nasopharyngeal Carcinoma Progression and Chemoresistance
Authors: Zi-Qi Zheng, Zhi-Xuan Li, Jia-Li Guan, Xu Liu, Jun-Yan Li, Yue Chen, Li Lin, Jia Kou, Jia-Wei Lv, Lu-Lu Zhang, Guan-Qun Zhou, Rui-Qi Liu, FoPing Chen, Xiao-Jun He, Ying-Qin Li, Feng Li, Si-Si Xu, Jun Ma, Na Liu, Ying Sun
Journal: Cancer Research (2020)

Abstract Frontier evidence suggests that dysregulation of long noncoding RNAs (lncRNA) is ubiquitous in all human tumors, indicating that lncRNAs might have essential roles in tumorigenesis. Therefore, an in-depth study of the roles of lncRNA in nasopharyngeal carcinoma (NPC) carcinogenesis might be helpful to provide novel therapeutic targets. Here we report that lncRNA TINCR was significantly upregulated in NPC and was associated positively with poor survival. Silencing TINCR inhibited NPC progression and cisplatin resistance. Mechanistically, TINCR bound ACLY and protected it from ubiquitin degradation to maintain total cellular acetyl-CoA levels. Accumulation of cellular acetyl-CoA promoted de novo lipid biosynthesis and histone H3K27 acetylation, which ultimately regulated the peptidyl arginine deiminase 1 (PADI1)–MAPK–MMP2/9 pathway. In addition, insulin-like growth factor 2 mRNA-binding protein 3 interacted with TINCR and slowed its decay, which partially accounted for TINCR upregulation in NPC. These findings demonstrate that TINCR acts as a crucial driver of NPC progression and chemoresistance and highlights the newly identified TINCR–ACLY–PADI1–MAPK–MMP2/9 axis as a potential therapeutic target in NPC. Significance: TINCR-mediated regulation of a PADI1–MAPK–MMP2/9 signaling pathway plays a critical role in NPC progression and chemoresistance, marking TINCR as a viable therapeutic target in this disease.
IL-4–BATF signaling directly modulates IL-9 producing mucosal mast cell (MMC9) function in experimental food allergy
Authors: Sunil Tomar, Varsha Ganesan, Ankit Sharma, Chang Zeng, Lisa Waggoner, Andrew Smith, Chang H. Kim, Paula Licona-Limón, Richard L. Reinhardt, Richard A. Flavell, Yui-Hsi Wang, Simon P. Hogan
Journal: Journal of Allergy and Clinical Immunology (2020)
10P Gender differences in molecular-guided therapy recommendations for metastatic malignant mesothelioma
Authors: H. Taghizadeh, S. Zöchbauer-Müller, R.M. Mader, L. Müllauer, T. Klikovits, M.A. Hoda, T. Bachleitner-Hofmann, G.W. Prager
Journal: Annals of Oncology (2020)
Hood Technique for Robotic Radical Prostatectomy—Preserving Periurethral Anatomical Structures in the Space of Retzius and Sparing the Pouch of Douglas, Enabling Early Return of Continence Without Compromising Surgical Margin Rates
Authors: Vinayak G. Wagaskar, Ankur Mittal, Stanislaw Sobotka, Parita Ratnani, Anna Lantz, Ugo Giovanni Falagario, Alberto Martini, Zach Dovey, Patrick-Julien Treacy, Prachee Pathak, Suit Nair, Berryhill Roy, Dimple Chakravarty, Sara Lewis, Kenneth Haines, Peter Wiklund, Ash Tewari
Journal: European Urology (2020)
Applying a Population Health Equity Framework in the Clinical Setting—Incorporating Social and Behavioral Determinants of Health Into Estimations of Risk
Authors: Chau Trinh-Shevrin
Journal: JAMA Network Open (2020)

Donna M. Zulman, MD; Matthew L. Maciejewski, PhD; Janet M. Grubber, MSPH; Hollis J. Weidenbacher, PhD; Dan V. Blalock, PhD; Leah L. Zullig, PhD; Liberty Greene, MS, MEd; Heather E. Whitson, MD; Susan N. Hastings, MD; Valerie A. Smith, DrPH
AB1065 VISIT COMPLIANCE IN PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER: RESULTS FROM A GAZI UNIVERSITY FMF COHORT
Authors: R. Bilici Salman, A. Avanoğlu Güler, H. Satiş, H. Karadeniz, H. Babaoglu, N. Atas, S. Haznedaroglu, M. A. Ozturk, B. Goker, A. Tufan
Journal: Annals of the Rheumatic Diseases (2020)

Background: Follow-up in all rheumatologic patients is critical, particularly Familial Mediterranean Fever (FMF). Current recommendations for all experts by the EULAR state that patients with FMF should be evaluated 6-monthly intervals to monitore the character and frequency of the attacks and the acute phase response. Disease-related complications such as amyloidosis can be asymptomatic and need only a careful follow-up. Objectives: to quantify this phenomenon and to find predictive factors of visit compliance in patients with FMF. Methods: The study included 474 adult patients with a diagnosis of FMF who followed at the outpatient rheumatology clinic of tertiary university hospital, from January 2018 to December 2018. . Demographic, socioeconomic data, familiy history, comorbid disease, medication history, characteristics, the International Severity Score for FMF (ISSF),autoinflammatory disease damage index (ADDI) were recorded. Visit compliance was defined as the presence of two visits in the outpatient rheumatology clinic for FMF last one year for the purposes set out in EULAR suggestion.Those who had fewer than two visits in the last one year were considered noncompliant. Results: 230 (48.5%) were compliant while 244 (51.5 %) patients were noncompliant with their rheumatology visit. Both compliant and noncompliant patients had similar median age and disease duration. Female sex and being married was increased the visit compliance.The results of the logistic regression model exploring factors associated with compliance indicated that presence of family history in parents, absence of family history in sibling, treatment with biologic agents, other drug using,presence of more than 2 attacks except fever and adequate medical care were important predictors of visit compliance. Conclusion: In conclusion, if FMF patients visit compliance increase, their functionality, medication adherence and quality of life will increase and flares and complication of disease can decrease. Thus, we highlight some recommendations for FMF specialist, patients and health care providers to improve outcomes. Table 2. Multivariate logistic regression analysis for predictive factors of visit compliance of the patients with FMF, n=430 Adj. OR %95 CI** p Family history in parents (positive history vs negative) 1,8 1,0-3,1 0.03 Family history in sibling (negative history vs positive) 1,9 1,2-3,1 0.004 Comorbid disease status 1,3 0,7-2,5 0.32 Treatment (anakinra&amp;canakinumab vs colchicine) 3,7 1,7-8,2 0.001 Drug using (other drugs vs FMF drugs) 2,2 1,1-4,4 0.01 More than 2 attacks except fever 2,3 1,2-4,0 0.004 Chronic peripheral arthritis 2,3 0,8-6,6 0.10 Proteinuria 2,2 0,7-6,7 0.14 Adequate medical care 1,9 1,2-3,1 0.003 Number of index flare within last 12-month 0,9 0,9-1,0 0.38 ISSF severity score 0,8 0,7-1,1 0,30 Disclosure of Interests: None declared
Growth Differentiation Factor 15 Provides Prognostic Information Superior to Established Cardiovascular and Inflammatory Biomarkers in Unselected Patients Hospitalized With COVID-19
Authors: Peder L. Myhre, Christian Prebensen, Heidi Strand, Ragnhild Røysland, Christine M. Jonassen, Anbjørg Rangberg, Vibecke Sørensen, Signe Søvik, Helge Røsjø, My Svensson, Jan Erik Berdal, Torbjørn Omland
Journal: Circulation (2020)

Background: Growth differentiation factor 15 (GDF-15) is a strong prognostic marker in sepsis and cardiovascular disease (CVD). The prognostic value of GDF-15 in coronavirus disease 2019 (COVID-19) is unknown. Methods: Consecutive, hospitalized patients with laboratory-confirmed infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and symptoms of COVID-19 were enrolled in the prospective, observational COVID Mechanisms Study. Biobank samples were collected at baseline, day 3 and day 9. The primary end point was admission to the intensive care unit or death during hospitalization, and the prognostic performance of baseline and serial GDF-15 concentrations were compared with that of established infectious disease and cardiovascular biomarkers. Results: Of the 123 patients enrolled, 35 (28%) reached the primary end point; these patients were older, more often had diabetes, and had lower oxygen saturations and higher National Early Warning Scores on baseline. Baseline GDF-15 concentrations were elevated (&gt;95th percentile in age-stratified healthy individuals) in 97 (79%), and higher concentrations were associated with detectable SARS-CoV-2 viremia and hypoxemia (both P &lt;0.001). Patients reaching the primary end point had higher concentrations of GDF-15 (median, 4225 [IQR, 3197–5972] pg/mL versus median, 2187 [IQR, 1344–3620] pg/mL, P &lt;0.001). The area under the receiver operating curve was 0.78 (95% CI, 0.70–0.86). The association between GDF-15 and the primary end point persisted after adjusting for age, sex, race, body mass index, estimated glomerular filtration rate, previous myocardial infarction, heart failure, and atrial fibrillation ( P &lt;0.001) and was superior and incremental to interleukin-6, C-reactive protein, procalcitonin, ferritin, D-dimer, cardiac troponin T, and N-terminal pro-B-type natriuretic peptide. Increase in GDF-15 from baseline to day 3 was also greater in patients reaching the primary end point (median, 1208 [IQR, 0–4305] pg/mL versus median, –86 [IQR, –322 to 491] pg/mL, P &lt;0.001). Conclusions: GDF-15 is elevated in the majority of patients hospitalized with COVID-19, and higher concentrations are associated with SARS-CoV-2 viremia, hypoxemia, and worse outcome. The prognostic value of GDF-15 was additional and superior to established cardiovascular and inflammatory biomarkers. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT04314232.
Health Policy after a Trump Election Victory
Authors: Mark V. Pauly
Journal: New England Journal of Medicine (2020)

Interview with Drs. Sherry Glied and Mark Pauly on what U.S. health policy could look like in the coming years under a Biden or a Trump administration. (18:12)Download If the ACA remains in effect, any changes in a second Trump administration are likely to be modest and to represent a continuation of efforts begun during Trump's first term. If the ACA is ruled unconstitutional, then far-reaching legislative changes will be required.
To a Young Man Accustomed to Terror (II)
Authors: Glenn Colquhoun
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cord blood DNA methylome in newborns later diagnosed with autism spectrum disorder reflects early dysregulation of neurodevelopmental and X-linked genes
Authors: Charles E. Mordaunt, Julia M. Jianu, Benjamin I. Laufer, Yihui Zhu, Hyeyeon Hwang, Keith W. Dunaway, Kelly M. Bakulski, Jason I. Feinberg, Heather E. Volk, Kristen Lyall, Lisa A. Croen, Craig J. Newschaffer, Sally Ozonoff, Irva Hertz-Picciotto, M. Daniele Fallin, Rebecca J. Schmidt, Janine M. LaSalle
Journal: Genome Medicine (2020)

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with complex heritability and higher prevalence in males. The neonatal epigenome has the potential to reflect past interactions between genetic and environmental factors during early development and influence future health outcomes.
SIDS and near-SIDS
Authors: Daniel C. Shannon, Dorothy H. Kelly
Journal: New England Journal of Medicine (1982)

Apnea and Respiratory ControlBecause sudden death without an obvious cause implies the cessation of autonomie regulation of cardiovascular or respiratory activity or both, it is important to understand how normal control mechanisms maintain ventilation and prevent or terminate apnea. It is even more pertinent because several investigators have identified abnormal breathing patterns or control mechanisms in infants in whom sudden-infant-death syndrome (SIDS) later occurred.Regulation of Skeletal Muscles of RespirationThis is a rapidly evolving area of research. Here we review only the features that are considered important to an understanding of episodic apnea or hypoventilation. The respiratory control . . .
18F-FDG PET/CT in the Diagnosis and Follow-up of Balint Syndrome
Authors: Francesco Dondi, Domenico Albano, Barbara Paghera, Francesco Bertagna, Raffaele Giubbini
Journal: Clinical Nuclear Medicine (2020)

Balint syndrome is a rare neurological disorder characterized by simultanagnosia, optic ataxia, and ocular apraxia, and its etiology can be very heterogeneous. Diagnosis is based on neuropsychological evaluation, but brain radiological and nuclear medicine imaging also plays an important role. Because few case reports have been published in literature, in this work, we present 2 patients affected by Balint syndrome in which 18F-FDG PET/CT helped in the diagnosis and follow-up.