tbuckley/cabot-search huggingface dataset:
A genome-wide association study identifies susceptibility loci for primary central nervous system lymphoma at 6p25.3 and 3p22.1: a LOC Network study
Authors: Karim Labreche, Mailys Daniau, Amit Sud, Philip J Law, Louis Royer-Perron, Amy Holroyd, Peter Broderick, Molly Went, Marion Benazra, Guido Ahle, Pierre Soubeyran, Luc Taillandier, Olivier L Chinot, Olivier Casasnovas, Jacques-Olivier Bay, Fabrice Jardin, Lucie Oberic, Michel Fabbro, Gandhi Damaj, Annie Brion, Karima Mokhtari, Cathy Philippe, Marc Sanson, Caroline Houillier, Carole Soussain, Khê Hoang-Xuan, Richard S Houlston, Agusti Alentorn, Marie-Pierre Moles-Moreau, Rémy Gressin, Vincent Delwail, Franck Morschhauser, Philippe Agapé, Arnaud Jaccard, Hervé Ghesquieres, Adrian Tempescul, Emmanuel Gyan, Jean-Pierre Marolleau, Roch Houot, Luc Fornecker, Anna-Luisa Di Stefano, Inès Detrait, Amithys Rahimian, Mark Lathrop, Diane Genet, Frédéric Davi, Nathalie Cassoux, Valérie Touitou, Sylvain Choquet, Anne Vital, Marc Polivka, Dominique Figarella-Branger, Alexandra Benouaich-Amiel, Chantal Campello, Frédéric Charlotte, Nadine Martin-Duverneuil, Loïc Feuvret, Aurélie Kas, Soledad Navarro, Chiara Villa, Franck Bielle, Fabrice Chretien, Marie Christine Tortel, Guillaume Gauchotte, Emmanuelle Uro-Coste, Catherine Godfrain, Valérie Rigau, Myrto Costopoulos, Magalie Le Garff-Tavernier, David Meyronnet, Audrey Rousseau, Clovis Adam, Thierry Lamy, Cécile Chabrot, Eileen M Boyle, Marie Blonski, Anna Schmitt
Journal: Neuro-Oncology (2019)

Abstract Background Primary central nervous system lymphoma (PCNSL) is a rare form of extra-nodal non-Hodgkin lymphoma. PCNSL is a distinct subtype of non-Hodgkin lymphoma, with over 95% of tumors belonging to the diffuse large B-cell lymphoma (DLBCL) group. We have conducted a genome-wide association study (GWAS) on immunocompetent patients to address the possibility that common genetic variants influence the risk of developing PCNSL. Methods We performed a meta-analysis of 2 new GWASs of PCNSL totaling 475 cases and 1134 controls of European ancestry. To increase genomic resolution, we imputed &gt;10 million single nucleotide polymorphisms using the 1000 Genomes Project combined with UK10K as reference. In addition we performed a transcription factor binding disruption analysis and investigated the patterns of local chromatin by Capture Hi-C data. Results We identified independent risk loci at 3p22.1 (rs41289586, ANO10, P = 2.17 × 10−8) and 6p25.3 near EXOC2 (rs116446171, P = 1.95 x 10−13). In contrast, the lack of an association between rs41289586 and DLBCL suggests distinct germline predisposition to PCNSL and DLBCL. We found looping chromatin interactions between noncoding regions at 6p25.3 (rs11646171) with the IRF4 promoter and at 8q24.21 (rs13254990) with the MYC promoter, both genes with strong relevance to B-cell tumorigenesis. Conclusion To our knowledge this is the first study providing insight into the genetic predisposition to PCNSL. Our findings represent an important step in defining the contribution of common genetic variation to the risk of developing PCNSL.
UNILATERAL VERSUS BILATERAL BILIARY DRAINAGE IN PATIENTS WITH BILIARY ANASTOMOTIC STRICTURES AFTER RIGHT-LOBE LIVING DONOR LIVER TRANSPLANTATION
Authors: WH Paik, MS You, SH Lee, JK Ryu, YT Kim
Journal: Endoscopy (2019)

Although there are usually two bile duct anastomosis sites, i.e. right anterior segment duct (RASD) and right posterior segment duct (RPSD) after in right lobe (RL)-living donor liver transplantation (LDLT), studies comparing unilateral and bilateral biliary drainage are largely lacking. This study aimed to evaluate efficacy and safety of unilateral and bilateral biliary drainage in patients with biliary strictures following RL-LDLT.
EARLY DIAGNOSIS IS ASSOCIATED WITH IMPROVED CLINICAL OUTCOME IN BENIGN ESOPHAGEAL PERFORATIONS: AN INDIVIDUAL PATIENT DATA META-ANALYSIS
Authors: B Vermeulen, B van der Leeden, C Rosman, P Siersema
Journal: Endoscopy (2019)

Timing between onset and diagnosis of BEP is regarded as an important risk factor for poor outcome. However, no strong evidence exists to support this finding. We investigated whether timing between onset and diagnosis is associated with clinical outcome of patients with BEP.
TNF-induced inflammatory genes escape repression in fibroblast-like synoviocytes: transcriptomic and epigenomic analysis
Authors: Christopher Loh, Sung-ho Park, Angela Lee, Ruoxi Yuan, Lionel B Ivashkiv, George D Kalliolias
Journal: Annals of the Rheumatic Diseases (2019)

We investigated genome-wide changes in gene expression and chromatin remodelling induced by tumour necrosis factor (TNF) in fibroblast-like synoviocytes (FLS) and macrophages to better understand the contribution of FLS to the pathogenesis of rheumatoid arthritis (RA).
THE ROLE OF ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY (ERCP) IN THE MANAGEMENT OF BILIARY COMPLICATIONS ASSOCIATED WITH ORTHOTOPIC LIVER TRANSPLANTATION (OLT)
Authors: B Antolín, J Tejedor, A Yaiza Carbajo, FJ García-Alonso, S Bazaga, C de la Serna-Higuera, M Pérez-Miranda
Journal: Endoscopy (2019)

To describe the prevalence of different biliary complications after OLT, their endoscopic management and the results obtained.
ENDOSCOPIC RETROGRADE DESINVAGINATION WITH DOUBLE BALLOON ENTEROSCOPE: A NEW ENDOSCOPY TREATMENT FOR SMALL BOWEL
Authors: E Pérez-Cuadrado Martínez, JF Sánchez Melgarejo, JM Rubio Mateos, MJ Sánchez Fernández, A Pérez Fernandez, PE Delgado, E Pérez-Cuadrado Robles
Journal: Endoscopy (2019)

Symptomatic intussusception of a long ileal segment in the colon has surgical treatment. Large-channel double balloon enteroscopy (DBE) (3.2 mm) is providing new therapeutic solutions.
Repurposing drugs as pro‐oxidant redox modifiers to eliminate cancer stem cells and improve the treatment of advanced stage cancers
Authors: Stephen J. Ralph, Sam Nozuhur, Reem Ali ALHulais, Sara Rodríguez‐Enríquez, Rafael Moreno‐Sánchez
Journal: Medicinal Research Reviews (2019)

Abstract Over the last decade, three major advances have contributed in improving the response rates against cancer including, immunotherapy; greater understanding of the molecular, biochemical, and cellular mechanisms in carcinogenesis thereby providing drug targets; and identification of reliable biomarkers for early detection to facilitate the earlier stage treatment of disease. However, no single universal cancer cure has yet been found, although combinations from the above areas have steadily improved survival outcomes. Hence, chemotherapy remains a key component in the oncologist's arsenal for cancer therapy, despite frequent development of drug resistance and more aggressive cancers with onset of advanced stage metastases. The focus here is to explore the repurposing of old drugs that cause pro‐oxidative overload to overcome onset of resistance to chemotherapy and enhance chemotherapeutic responses, particularly against metastatic cancer. Excellent examples of US Food and Drug Administration approved drugs suitable for repurposing are the potent and specific thioreductase inhibitor auranofin and the nonsteroidal anti‐inflammatory drug, celecoxib. Recently, both drugs were shown to selectively target and kill metastatic cancer cells and cancer stem cells (CSCs), predominantly by promoting excessive mitochondrial reactive oxygen species. Thus, targeting intracellular redox systems of advanced stage metastatic cancer cells and CSCs can promote an overload of pro‐oxidative stress to activate the intrinsic pathway for programmed cell death. It is envisaged that more clinical studies will incorporate longer term use of repurposed drugs, such as auranofin or celecoxib, to target redox systems in cancer cells as part of common practice postcancer diagnosis, providing enhanced chemotherapeutic responses and increased cancer survival.
THE POLYP-BASED RESECT-AND-DISCARD STRATEGY
Authors: A Duong, M Bouin, E Deslandres, R Leduc, A Deshêtres, A Weber, H Pohl, A Barkun, D Renteln
Journal: Endoscopy (2019)

Current clinical practice assigns post-polypectomy surveillance intervals based on the number, size and histological aspects of polyps. Our goal was to test a novel polyp-based resect and discard model that assigns surveillance intervals for small polyps based only on size and number of polyps.
RESTORATION OF A RARE, IMPRESSIVE AESTHETIC CERVICAL DYSMORPHIA DUE TO OESOPHAGEAL ACHALASIA BY PERORAL ENDOSCOPIC MYOTOMY PROCEDURE
Authors: K Delis, I Robotis, A Prevezianou, S Lamprinakos, M Leontis, O Ampartzidou
Journal: Endoscopy (2019)

An aesthetic advantage of peroral endoscopic myotomy procedure (POEM) on achalasic patients against surgical approaches, is the absence of abdominal or thoracic skin scars. The aim of this abstract is to present another impressive aesthetic result, succeeded via therapy of an achalasic patient with POEM, which simultaneously corrected an accompanied rare extensive aesthetic cervical dysmorphia, as well.
Abstract 12916: Cost-Related Medication Non-Adherence in Nonelderly With Atherosclerotic Cardiovascular Disease in the United States, 2013-2016
Authors: Rohan Khera, Javier Valero-Elizondo, Anshul Saxena, Javed Butler, Zainab Samad, Salim S Virani, Harlan M Krumholz, Khurram Nasir
Journal: Circulation (2018)

Introduction: Medication non-adherence portends worse outcomes in those with atherosclerotic cardiovascular disease (ASCVD) - a group that requires chronic therapy for secondary prevention. Such no...
Financial incentives for physical activity in adults: systematic review and meta-analysis
Authors: Marc S Mitchell, Stephanie L Orstad, Aviroop Biswas, Paul I Oh, Melanie Jay, Maureen T Pakosh, Guy Faulkner
Journal: British Journal of Sports Medicine (2019)

Objective The use of financial incentives to promote physical activity (PA) has grown in popularity due in part to technological advances that make it easier to track and reward PA. The purpose of this study was to update the evidence on the effects of incentives on PA in adults. Data sources Medline, PubMed, Embase, PsychINFO, CCTR, CINAHL and COCH. Eligibility criteria Randomised controlled trials (RCT) published between 2012 and May 2018 examining the impact of incentives on PA. Design A simple count of studies with positive and null effects (‘vote counting’) was conducted. Random-effects meta-analyses were also undertaken for studies reporting steps per day for intervention and post-intervention periods. Results 23 studies involving 6074 participants were included (64.42% female, mean age = 41.20 years). 20 out of 22 studies reported positive intervention effects and four out of 18 reported post-intervention (after incentives withdrawn) benefits. Among the 12 of 23 studies included in the meta-analysis, incentives were associated with increased mean daily step counts during the intervention period (pooled mean difference (MD), 607.1; 95% CI: 422.1 to 792.1). Among the nine of 12 studies with post-intervention daily step count data incentives were associated with increased mean daily step counts (pooled MD, 513.8; 95% CI:312.7 to 714.9). Conclusion Demonstrating rising interest in financial incentives, 23 RCTs were identified. Modest incentives ($1.40 US/day) increased PA for interventions of short and long durations and after incentives were removed, though post-intervention ‘vote counting’ and pooled results did not align. Nonetheless, and contrary to what has been previously reported, these findings suggest a short-term incentive ‘dose’ may promote sustained PA.
International Cancer Microbiome Consortium consensus statement on the role of the human microbiome in carcinogenesis
Authors: Alasdair J Scott, James L Alexander, Claire A Merrifield, David Cunningham, Christian Jobin, Robert Brown, John Alverdy, Stephen J O’Keefe, H Rex Gaskins, Julian Teare, Jun Yu, David J Hughes, Hans Verstraelen, Jeremy Burton, Paul W O’Toole, Daniel W Rosenberg, Julian R Marchesi, James M Kinross
Journal: Gut (2019)

In this consensus statement, an international panel of experts deliver their opinions on key questions regarding the contribution of the human microbiome to carcinogenesis.International experts in oncology and/or microbiome research were approached by personal communication to form a panel. A structured, iterative, methodology based around a 1-day roundtable discussion was employed to derive expert consensus on key questions in microbiome-oncology research.Some 18 experts convened for the roundtable discussion and five key questions were identified regarding: (1) the relevance of dysbiosis/an altered gut microbiome to carcinogenesis; (2) potential mechanisms of microbiota-induced carcinogenesis; (3) conceptual frameworks describing how the human microbiome may drive carcinogenesis; (4) causation versus association; and (5) future directions for research in the field.The panel considered that, despite mechanistic and supporting evidence from animal and human studies, there is currently no direct evidence that the human commensal microbiome is a key determinant in the aetiopathogenesis of cancer. The panel cited the lack of large longitudinal, cohort studies as a principal deciding factor and agreed that this should be a future research priority. However, while acknowledging gaps in the evidence, expert opinion was that the microbiome, alongside environmental factors and an epigenetically/genetically vulnerable host, represents one apex of a tripartite, multidirectional interactome that drives carcinogenesis.Data from longitudinal cohort studies are needed to confirm the role of the human microbiome as a key driver in the aetiopathogenesis of cancer.
"POSTERIOR-LIKE" ANTERIOR POEM
Authors: G Mavrogenis, F Bazerbachi, I Tsevgas, G Karamanolis, D Zachariadis
Journal: Endoscopy (2019)

Per Oral Endoscopic Myotomy (POEM) can be performed via an anterior or posterior approach to the esophageal wall, depending on the operator's preference. Recent data, however, show that posterior POEM is faster in accomplishing myotomy and in mucosal closure time with less risk for inadvertent mucosal injury. These advantages are attributed to the axis of the dissection plane which naturally parallels to the endoscope working channel. Conversely, anterior POEM has been associated with less esophageal acid exposure post myotomy. Moreover, the gravity-dependent pooling of liquids occurs away from the dissection plane. Therefore, we have recently introduced a modified version of anterior POEM, named 'Posterior-Like' anterior POEM, in which the operator simulates the experience of posterior POEM while performing anterior POEM, by means of ergonomic shifts. This is done through anticlockwise rotation of the endoscope shaft, while simultaneously rotating the operator's body to face another monitor placed by the patient's feet. In this fashion, the tunnel and the myotomy axis are positioned at 6 o'clock, as in posterior POEM. The purpose of this video is to present step by step this technique in a case of type I Achalasia.
Socioeconomic Inequality in Metabolic Control Among Children With Type 1 Diabetes: A Nationwide Longitudinal Study of 4,079 Danish Children
Authors: Nick F. Nielsen, Amanda Gaulke, Tine M. Eriksen, Jannet Svensson, Niels Skipper
Journal: Diabetes Care (2019)

OBJECTIVE To examine inequality in glycemic control by maternal educational level among children with type 1 diabetes in a setting with universal access to health care. RESEARCH DESIGN AND METHODS This was a longitudinal nationwide study of 4,079 Danish children with type 1 diabetes between the years 2000 and 2013. Children were divided into four groups based on mothers’ education prebirth (≤high school [n = 1,643], vocational or 2-year college [n = 1,548], bachelor’s degree [n = 695], ≥master’s degree [n = 193]). Means of socioeconomic and treatment characteristics were compared between groups. HbA1c and the number of daily glucose tests were compared repeatedly from onset until 5 years after onset across groups. HbA1c was compared across daily blood glucose testing frequency and groups. Linear regression was used to compare HbA1c across groups with and without adjustment for socioeconomic and treatment characteristics. RESULTS Large differences in HbA1c across maternal education were found. The mean level of HbA1c during follow-up was 59.7 mmol/mol (7.6%) for children of mothers with ≥master’s degrees and 68.7 mmol/mol (8.4%) for children of mothers with ≤high school (difference: 9.0 mmol/mol [95% CI 7.5, 10.6]; 0.8% [95% CI 0.7, 1.0]). The associations were attenuated but remained significant after adjustment. Observable characteristics explained 41.2% of the difference in HbA1c between children of mothers with ≤high school and mothers with ≥master’s degree; 22.5% of the difference was explained by more frequent blood glucose monitoring among the children with the highly educated mothers. CONCLUSIONS Family background is significantly related to outcomes for children with type 1 diabetes, even with universal access to health care.
Abstract 11258: A Telemonitoring Service Approved by the Ministry of Health for a Large-Scale Screening of Silent and Symptomatic Atrial Fibrillation
Authors: Savina Nodari, Laura Lupi, Fulvio Glisenti, Gianfranco Gensini, Ilaria Papa, Davide Fabbricatore, Mariangela Piazzani, Gianmarco Arabia, Francesco Gabbrielli
Journal: Circulation (2018)

Introduction: despite good progress in the management of patients with atrial fibrillation (AF), this disease remains one of the major cause of stroke, heart failure, sudden death and cardiovascula...
CUTTING DELAY DURING POLYPECTOMY OF A LARGE PEDUNCULATED POLYP IN THE CAECUM – USE OF A PARTIALLY ISOLATED SNARE
Authors: SK Gölder, A Ebigbo, H Messmann
Journal: Endoscopy (2019)

A 69-year old female patient was submitted for endoscopic resection of a large pedunculated polyp in the caecum. After submucosal injection with 10 ml of diluted epinephrine solution, a braided wire snare (25 mm, Olympus-Europe, Hamburg, Germany) was placed around the lesion. Cutting with the HF Unit ERBE VIO 300 (ERBE-Elektromedizin, Tübingen, Germany) was started with EndoCUT Q Effect 3, however, no cutting current could be established at the polyp stalk.
Abstract P059: Multiple Cause-of-Death Analysis Reveals Under Reporting of Disease Burden for Diabetes
Authors: Katherine G Hastings, Jiaqi Hu, Nadejda Marques, Eric J Daza, Mark Cullen, Latha Palaniappan
Journal: Circulation (2017)

Introduction: Despite being considerably under reported as the underlying cause of death on death certificates, and consequently on mortality figures, diabetes is among the ten leading causes of death in the U.S. A multiple cause-of-death analysis shows the extent to which diabetes is associated with other leading causes of death. Hypothesis: Analysis of multiple-cause-of-death will confirm prevalence rates of diabetes among racial/ethnic minority populations, demonstrate the impact of diabetes in association with other causes of death, and highlight variations of burden of disease among different racial/ethnic groups. Methods: Causes of death were identified using the Multiple Cause Mortality Files of the National Center for Health Statistics from 2003 to 2012. Age-adjusted mortality rates were calculated for diabetes both as the underlying cause of death (UCD) and as multiple causes of death (MCD) by racial/ethnic groups (NHWs, Blacks, Asians, and Hispanic/Latinos). Frequencies and proportions were calculated by race/ethnicity groups. Linear regression model was used for number of causes per death. Results: A total of 2,335,198 decedents had diabetes listed as MCD in the U.S. national death records from 2003-2012. Mortality rates of diabetes as MCD were 3.4 times than UCD for Asians, 2.9 times for Blacks, 2.9 times for Hispanics and 3.7 times for NHWs (Figure). Minority populations had higher proportion of deaths with diabetes reported as MCD than NHWs (1.7 times higher for Hispanics, 1.5 times higher for Blacks and Asians). Adjusting for age, gender, and race/ethnicity, there were 1.7 more causes per death co-occurred for diabetes decedents compared to decedents who died due to all other causes (95% CI: 1.714, 1.718). Conclusions: Our findings underscore the importance of a multiple-cause-of-death approach in the analyses for a more comprehensive understanding of the impact of diabetes.
ENDOSCOPIC ULTRASOUND-GUIDED HYBRIDTHERM ABLATION (EUS-HTP) IN PATIENTS (PTS) WITH LOCALLY ADVANCED (LA) PANCREATIC DUCTAL ADENOCARCINOMA (PDAC): A CASE-CONTROL COMPARATIVE SURVIVAL ANALYSIS
Authors: S Testoni, MC Petrone, W Linzenbold, M Enderle, G Capurso, G Rossi, L Archibugi, M Traini, M Reni, M Falconi, PG Arcidiacono
Journal: Endoscopy (2019)

Aim of the study was to assess the survival outcomes of pts with LA PDAC treated with chemotherapy ± radiotherapy (CT ± RT) plus endosonography-guided HybridTherm ablation (EUS-HTP) vs. those receiving only CT ± RT.
Association of Intensive Blood Pressure Reduction With Risk of Hematoma Expansion in Patients With Deep Intracerebral Hemorrhage
Authors: Audrey C. Leasure, Adnan I. Qureshi, Santosh B. Murthy, Hooman Kamel, Joshua N. Goldstein, Daniel Woo, Wendy C. Ziai, Daniel F. Hanley, Rustam Al-Shahi Salman, Charles C. Matouk, Lauren H. Sansing, Kevin N. Sheth, Guido J. Falcone
Journal: JAMA Neurology (2019)

Hypertension is the strongest risk factor for spontaneous intracerebral hemorrhage (ICH) involving deep brain regions, but it appears to be unknown if intensive blood pressure reduction in the acute care setting decreases hematoma expansion or improves outcomes in patients with deep ICH.To determine whether intensive blood pressure reduction is associated with decreased risk of hematoma expansion and changes in 90-day modified Rankin Scale scores and if these associations are modified by the specific deep-brain nuclei involved.This study is an exploratory analysis of the Antihypertensive Treatment of Acute Cerebral Hemorrhage-2 international, multicenter randomized clinical trial, which was conducted from May 2011 to September 2015, enrolled eligible patients with primary ICH, and followed up with them for 90 days. Patients who had ICH and complete neuroimaging data were included in the analysis. Data analysis was completed from July 2018 to December 2018.Participants were randomized to either intensive treatment (with a systolic blood pressure target of 110-139 mm Hg) or standard treatment (with a systolic blood pressure target of 140-179 mm Hg).The main outcome was hematoma expansion, defined as an increase greater than 33% in hematoma volume between baseline and 24 hours. Functional outcome was evaluated 90 days after the ICH via the modified Rankin Scale.Of 1000 trial participants, 870 (87.0%) had deep ICH, of whom 780 (89.7%) had complete neuroimaging data (of 336 thalamic and 444 basal ganglia hemorrhages). The baseline characteristics of the intensive and standard treatment groups remained balanced in this subgroup of the original study. Intensive treatment was associated with a decreased risk of hematoma expansion in univariable analysis (odds ratio [OR], 0.62 [95% CI, 0.43-0.87]; P = .006) and multivariable analysis (OR, 0.61 [95% CI, 0.42-0.88]; P = .009). This association was modified by the specific deep location of the ICH (OR, 0.44 [95% CI, 0.22-0.96]; interaction P = .02), with stratified analyses showing a reduction in risk of hematoma expansion with intensive vs standard treatment among basal ganglia ICH (OR, 0.44 [95% CI, 0.27-0.72]; P = .001) but not thalamic ICH (OR, 0.91 [95% CI, 0.51-0.64]; P = .76). Intensive treatment was not associated with an improvement in the modified Rankin Scale score distribution.Compared with standard treatment, intensive blood pressure treatment was associated with reduced hematoma expansion in deep ICH, specifically among basal ganglia hemorrhages.