tbuckley/cabot-search huggingface dataset:
Weight loss in psoriasis and psoriatic arthritis
Authors: S.K. Mahil, S.M. McSweeney, E. Kloczko, B. McGowan, J.N. Barker, C.H. Smith
Journal: British Journal of Dermatology (2019)

Psoriasis is an incurable skin condition that affects between two and four in every 100 people in the Western world. It causes uncomfortable, red scaly patches on the skin, and is also linked with joint disease, high body weight (‘obesity’), heart attacks and low mood. Previous studies have shown that being obese can worsen psoriasis and it is thought that losing weight may improve it. Inspired by the difficulties faced by a patient with severe psoriasis and obesity, the authors of this U.K.‐based study aimed to identify the effect of weight loss on psoriasis and whether losing weight could prevent psoriasis from developing. The authors systematically searched scientific literature databases and identified 14 relevant studies examining three key weight loss methods: lifestyle changes (diet and exercise), weight loss medications, and weight loss surgery (e.g. gastric bypass). These studies showed that weight loss following lifestyle changes can produce a consistent improvement in psoriasis in obese patients. The researchers identified few studies examining the effect of weight loss medications and weight loss surgery in individuals with psoriasis, which did not have clear or consistent results. Two studies were identified that showed that weight loss surgery can prevent the onset of psoriasis. The authors explained this information to their patient, who was encouraged to lose weight alongside other treatments he received for his psoriasis. They also created a care pathway within their psoriasis clinic to help all patients with psoriasis and obesity to lose weight.
AAV-Mediated Gene Transfer Restores a Normal Muscle Transcriptome in a Canine Model of X-Linked Myotubular Myopathy
Authors: Jean-Baptiste Dupont, Jianjun Guo, Edith Renaud-Gabardos, Karine Poulard, Virginie Latournerie, Michael W. Lawlor, Robert W. Grange, John T. Gray, Ana Buj-Bello, Martin K. Childers, David L. Mack
Journal: Molecular Therapy (2019)

Multiple clinical trials employing recombinant adeno-associated viral (rAAV) vectors have been initiated for neuromuscular disorders, including Duchenne and limb-girdle muscular dystrophies, spinal muscular atrophy, and recently X-linked myotubular myopathy (XLMTM). Our previous work on a canine model of XLMTM showed that a single rAAV8-cMTM1 systemic infusion corrected structural abnormalities within the muscle and restored contractile function, with affected dogs surviving more than 4 years post injection. This remarkable therapeutic efficacy presents a unique opportunity to identify the downstream molecular drivers of XLMTM pathology and to what extent the whole muscle transcriptome is restored to normal after gene transfer. Herein, RNA-sequencing was used to examine the transcriptomes of the Biceps femoris and Vastus lateralis in a previously described canine cohort that showed dose-dependent clinical improvements after rAAV8-cMTM1 gene transfer. Our analysis confirmed several dysregulated genes previously observed in XLMTM mice but also identified transcripts linked to XLMTM pathology. We demonstrated XLMTM transcriptome remodeling and dose-dependent normalization of gene expression after gene transfer and created metrics to pinpoint potential biomarkers of disease progression and correction.
Chromatin establishes an immature version of neuronal protocadherin selection during the naive-to-primed conversion of pluripotent stem cells
Authors: Angels Almenar-Queralt, Daria Merkurjev, Hong Sook Kim, Michael Navarro, Qi Ma, Rodrigo S. Chaves, Catarina Allegue, Shawn P. Driscoll, Andrew G. Chen, Bridget Kohlnhofer, Lauren K. Fong, Grace Woodruff, Carlos Mackintosh, Dasa Bohaciakova, Marian Hruska-Plochan, Takahiro Tadokoro, Jessica E. Young, Nady El Hajj, Marcus Dittrich, Martin Marsala, Lawrence S. B. Goldstein, Ivan Garcia-Bassets
Journal: Nature Genetics (2019)
Higher Stability of Mutant mRNA As Compared to Wild-Type mRNA in Diffuse Large B-Cell Lymphoma
Authors: Maher Albitar, Zijun Yidan Xu-Monette, Wanlong Ma, Yingjun Wang, Deng Manman, Alexandar Tzankov, Carlo Visco, Govind Bhagat, Karen Dybkær, Ivan De Dios, Wayne Tam, Eric D. Hsi, Maurilio Ponzoni, Andres JM Ferreri, Michael Boe Møller, Miguel A. Piris, Joannes H.J.M. Van Krieken, Youli Zu, Hagop M. Kantarjian, Yong Li, Ken H. Young
Journal: Blood (2019)
Phenotypic Characterization of Leukemia-Initiating Stem Cells in Chronic Myelomonocytic Leukemia (CMML)
Authors: Gregor Eisenwort, Alexandra Keller, Michael Willmann, Irina Sadovnik, Greiner Georg, Karoline V. Gleixner, Daniel Ivanov, Daniela Berger, Gabriele Stefanzl, Christiana Winding, Gregor Hoermann, Wolfgang R. Sperr, Heinz Sill, Peter Bettelheim, Klaus Geissler, Michael W. Deininger, Thomas Rülicke, Peter Valent
Journal: Blood (2019)
Mongolism in One of Twins
Authors: T. H. Crozier, W. A. B. Campbell
Journal: BMJ (1950)

It was obviously important to find out whether the patient had at any time between the delivery and the follow-up investi- gation been pregnant.This seemed impossible.She had attended a welfare centre regularly.Husband and wife con- firmed the use of birth control (by male sheath) because they did not desire a second child until they no longer had to live in the same house as a relative suffering from pulmonary tuberculosis.The patient gave a history of regular menses and had received no injections of any kind either ante-or post-natally, and had never received a transfusion.Case 2 A woman aged 22 was delivered of a living healthy, full-term baby on September 19, 1948.The infant showed no signs of haemolytic disease of the newborn.The infant's blood type was Group A rhesus-positive.The maternal serology antenatally was Group A rhesus- negative, the serum containing no anomalous antibodies.A specimen of blood obtained on the eighth day after delivery gave identical results.A further specimen, however, obtained on June 22, 1949, gave definite evidence of the presence of a potent anti-rhesus antibody, again acting more strongly on albumin-suspended rhesus-positive cells.The titre was moderately high (1: 8).The serological behaviour of the anti- body was typical, no reaction occurring unless the test cells contained the D antigen.This patient had shown no sign of a further pregnancy, her menses having been regular since the cessation of lactation three months after delivery.She had received no injections ante-or post-natally or transfusions at any time of her life.Her husband was Group 0 rhesus-positive and most likely genotype CDe/cde.
Apelin directs endothelial cell differentiation and vascular repair following immune-mediated injury
Authors: Andrew G. Masoud, Jiaxin Lin, Abul K. Azad, Maikel A. Farhan, Conrad Fischer, Lin F. Zhu, Hao Zhang, Banu Sis, Zamaneh Kassiri, Ronald B. Moore, Daniel Kim, Colin C. Anderson, John C. Vederas, Benjamin A. Adam, Gavin Y. Oudit, Allan G. Murray
Journal: Journal of Clinical Investigation (2019)

Sustained, indolent immune injury of the vasculature of a heart transplant limits long-term graft and recipient survival. This injury is mitigated by a poorly characterized, maladaptive repair response. Vascular endothelial cells respond to proangiogenic cues in the embryo by differentiation to specialized phenotypes, associated with expression of apelin. In the adult, the role of developmental proangiogenic cues in repair of the established vasculature is largely unknown. We found that human and minor histocompatibility–mismatched donor mouse heart allografts with alloimmune-mediated vasculopathy upregulated expression of apelin in arteries and myocardial microvessels. In vivo, loss of donor heart expression of apelin facilitated graft immune cell infiltration, blunted vascular repair, and worsened occlusive vasculopathy in mice. In vitro, an apelin receptor agonist analog elicited endothelial nitric oxide synthase activation to promote endothelial monolayer wound repair and reduce immune cell adhesion. Thus, apelin acted as an autocrine growth cue to sustain vascular repair and mitigate the effects of immune injury. Treatment with an apelin receptor agonist after vasculopathy was established markedly reduced progression of arterial occlusion in mice. Together, these initial data identify proangiogenic apelin as a key mediator of coronary vascular repair and a pharmacotherapeutic target for immune-mediated injury of the coronary vasculature.
Abstract 14210: Phenotype, but Not Genotype, Determines Survival in Pediatric Dilated Cardiomyopathy: A Study From the NHLBI-Funded Pediatric Cardiomyopathy Registry
Authors: Paul F Kantor, Stephanie M Ware, Ling Shi, Steven A Webber, Wendy K Chung, Teresa M Lee, Bruce Aronow, Neha Bansal, Surbhi Bhatnagar, Phillip J Dexheimer, John L Jefferies, Ashwin K Lal, Lisa J Martin, Erin M Miller, Joseph Rossano, Jeffrey Schubert, Arthi Sridhar, Muhammad Tariq, Hiedy Razoky, Jason Czachor, James D Wilkinson, Steven E Lipshultz
Journal: Circulation (2018)

Introduction: Single-gene mutations are a known cause of dilated cardiomyopathy (DCM) in children, but the strength of association between gene-mutations and disease severity is uncertain. Combinin...
RARE-13. CHARACTERISTICS AND TREATMENT PATTERNS IN CHILDREN WITH NEUROFIBROMATOSIS TYPE 1 (NF1) AND PLEXIFORM NEUROFIBROMAS (PN): A CROSS-SECTIONAL ANALYSIS OF CHILDREN’S TUMOR FOUNDATION (CTF) REGISTRY DATA
Authors: Jinghua He, Cathy Anne Pinto, Xiaoqin Yang, Scott Diede, Anne Deitz
Journal: Neuro-Oncology (2019)

Abstract BACKGROUND NF1-related PN can cause substantial morbidity, with no currently approved drug treatment available for PN treatment. Although surgery is the standard of care, complete resection of PN is often difficult due to encasement of vital structures and invasive and extensive PN growth. With limited real-world data among children with NF1-related PN, the study objectives were to describe the demographic, clinical characteristics, and treatment of these children. METHODS A cross-sectional analysis of existing CTF web-based, patient-entered, registry data collected between 2012–2018 was conducted. To be included in analysis, patients had to complete at least one registry survey, and be ≤ 19 years of age at the time of first survey completion, with patient- or parent/ guardian reported diagnosis of NF1 and at least 1 PN. Descriptive statistical analysis was conducted on data collected from the first survey for each patient, to describe patient characteristics and treatment patterns. Results were stratified by region (US, ex-US). RESULTS The sample included 943 pediatric patients (n=750 US, n=193 ex-US). The majority (85.9%) were less than 5 years of age at NF1 diagnosis (US: 87.6%; ex-US: 79.3%). Approximately half were male, and half reported more than 1 PN. The most common PN site include head (15.1%) and neck (12.6%). More than half of patients received no treatment (53.1%) for their PN. The most common treatments reported for PN were surgery (27.0%) and chemotherapy or drug therapy (10.0%). These results were generally consistent across regions. A malignant peripheral nerve sheath tumor (MPNST) and optic glioma (OG) were diagnosed in 21 (2.2%) and 308 (32.7%) patients, respectively; a large proportion of OG patients remained untreated (57.5%). Too few ex-US patients were available for detailed regional analysis. CONCLUSIONS This study demonstrated that a large proportion of children diagnosed with NF1-related PN remain untreated, highlighting a substantial unmet need.
Contamination of health-care workers' hands with Escherichia coli and Klebsiella species after routine patient care: a prospective observational study
Authors: M. Puig-Asensio, D.J. Diekema, L. Boyken, G.S. Clore, J.L. Salinas, E.N. Perencevich
Journal: Clinical Microbiology and Infection (2019)
External Cardiac Compression
Authors: R. Binning
Journal: BMJ (1962)

and require treatment in a casualty department, or enter hospital as a surgical or obstetric emergency.We have heard of a patient undergoing treatment with a mono- amine oxidase inhibitor dying following a pethidine injection given in a casualty department.Some of the firms producing these drugs have -been careful recently to draw the attention of doctors to the risks involved-for example, Warner's (nardil)-but others have remained reticent, such warnings as appear in their literature not being as distinctive as one would expect under the circumstances.If the present wide- spread use of these drugs is to continue would it not be advisable to provide the patient with a card stating that he or she is being treated with-the drug and explaining the risks involved-that is, similar to the system used in patients on long-term steroid or anticoagulant therapy ?Lastly, may we add just one other preparation, phenoxypropazine (" drazine ") to complete the excellent list of monoamine oxidase inhibitors provided by Drs.
Correlation of homologous recombination deficiency induced mutational signatures with sensitivity to PARP inhibitors and cytotoxic agents
Authors: Ádám Póti, Hella Gyergyák, Eszter Németh, Orsolya Rusz, Szilárd Tóth, Csenger Kovácsházi, Dan Chen, Bernadett Szikriszt, Sándor Spisák, Shunichi Takeda, Gergely Szakács, Zoltan Szallasi, Andrea L. Richardson, Dávid Szüts
Journal: Genome biology (2019)

Homologous recombination (HR) repair deficiency arising from defects in BRCA1 or BRCA2 is associated with characteristic patterns of somatic mutations. In this genetic study, we ask whether inactivating mutations in further genes of the HR pathway or the DNA damage checkpoint also give rise to somatic mutation patterns that can be used for treatment prediction.Using whole genome sequencing of an isogenic knockout cell line panel, we find a universal HR deficiency-specific base substitution signature that is similar to COSMIC signature 3. In contrast, we detect different deletion phenotypes corresponding to specific HR mutants. The inactivation of BRCA2 or PALB2 leads to larger deletions, typically with microhomology, when compared to the disruption of BRCA1, RAD51 paralogs, or RAD54. Comparison with the deletion spectrum of Cas9 cut sites suggests that most spontaneously arising genomic deletions are not the consequence of double-strand breaks. Surprisingly, the inactivation of checkpoint kinases ATM and CHK2 has no mutagenic consequences. Analysis of tumor exomes with biallelic inactivating mutations in the investigated genes confirms the validity of the cell line models. We present a comprehensive analysis of sensitivity of the investigated mutants to 13 therapeutic agents for the purpose of correlating genomic mutagenic phenotypes with drug sensitivity.Our results suggest that no single genomic mutational class shows perfect correlation with sensitivity to common treatments, but the contribution of COSMIC signature 3 to base substitutions, or a combined measure of different features, may be reasonably good at predicting platinum and PARP inhibitor sensitivity.
Fever Characteristics Associated with Toxicity and Outcome after Anti-CD19 CAR T-Cell Therapy for Aggressive Lymphoma
Authors: Hamza Hashmi, Alicia Darwin, Christina A Bachmeier, Julio Chavez, Bijal Shah, Javier Pinilla Ibarz, Taiga Nishihori, Farhad Khimani, Aleksandr Lazaryan, Hien D. Liu, Marco L. Davila, Frederick L. Locke, Michael D. Jain
Journal: Blood (2019)
No Increased Risk of Cataract in Immune Thrombocytopenia Adult Patients Treated with Eltrombopag. a French Nationwide Nested Case-Control Study
Authors: Margaux Lafaurie, Bérangère Baricault, Vincent Soler, Myriam Cassagne, Laurent Sailler, Maryse Lapeyre-Mestre, Agnès Sommet, Guillaume Moulis
Journal: Blood (2019)
A Cautionary Report of Doxycycline‐Induced Autoimmune Hepatitis
Authors: Ali Fakhreddine, Catherine Frenette
Journal: Hepatology (2019)

1Division of Gastroenterology and HepatologyScripps ClinicLa JollaCA 2Center for Organ and Cell TransplantationScripps ClinicLa JollaCA * Address Correspondence and Reprint Requests to: Ali Fakhreddine, M.D. Division of Gastroenterology and Hepatology, Scripps Clinic 10666 N Torrey Pines Rd, N203 La Jolla, CA 92037 E‐mail: [email protected]
Is There Any Impact of Uric Acid Levels during the Peri-Transplant Period on Acute Graft Vs. Host Disease Incidence and Allotransplant Outcome?
Authors: Panayotis Kaloyannidis, Hussin Alsubaie, Rawan Omari, Solaf Kanfar, Zahra Abdrabalamir Alshammasi, Mohammed Darweesh, Enas Mutahar, Kenana Ajlan, Abdulhamid Liacini, Norah Muhlem, Ahmed Bahrani, Afra Dayel, John Apostolidis, Hani Al Hashmi, Khalid Ahmed Al-Anazi
Journal: Blood (2019)
Cardiovascular risk of electronic cigarettes: a review of preclinical and clinical studies
Authors: Nicholas D Buchanan, Jacob A Grimmer, Vineeta Tanwar, Neill Schwieterman, Peter J Mohler, Loren E Wold
Journal: Cardiovascular Research (2019)

Abstract Cigarette smoking is the most preventable risk factor related to cardiovascular morbidity and mortality. Tobacco usage has declined in recent years; however, the use of alternative nicotine delivery methods, particularly e-cigarettes, has increased exponentially despite limited data on their short- and long-term safety and efficacy. Due to their unique properties, the impact of e-cigarettes on cardiovascular physiology is not fully known. Here, we summarize both preclinical and clinical data extracted from short- and long-term studies on the cardiovascular effects of e-cigarette use. Current findings support that e-cigarettes are not a harm-free alternative to tobacco smoke. However, the data are primarily derived from acute studies. The impact of chronic e-cigarette exposure is essentially unstudied. To explore the uniqueness of e-cigarettes, we contemplate the cardiovascular effects of individual e-cigarette constituents. Overall, data suggest that exposure to e-cigarettes could be a potential cardiovascular health concern. Further preclinical research and randomized trials are needed to expand basic and clinical investigations before considering e-cigarettes safe alternatives to conventional cigarettes.
Results from CARTITUDE-1: A Phase 1b/2 Study of JNJ-4528, a CAR-T Cell Therapy Directed Against B-Cell Maturation Antigen (BCMA), in Patients with Relapsed and/or Refractory Multiple Myeloma (R/R MM)
Authors: Deepu Madduri, Saad Z. Usmani, Sundar Jagannath, Indrajeet Singh, Enrique Zudaire, Tzu-Min Yeh, Alicia J. Allred, Arnob Banerjee, Jenna D. Goldberg, Jordan M Schecter, Sen Zhuang, Jeffrey R. Infante, Syed Rizvi, Xiaohu (Frank) Fan, Andrzej Jakubowiak, Jesus G. Berdeja
Journal: Blood (2019)
Tolerability in Patients with Multiple Myeloma Treated with Daratumumab: A Systematic Review and Meta-Analysis of Phase III Randomized Controlled Trials
Authors: Thura Win Htut, Myint Aung Win, Sriman Swarup, Anita Sultan, Nimesh Adhikari, Ei Moe Phyu, Akshar Dash, Myat Min Han, Yin Mon Myat, Sanjay Awasthi, Lukman Tijani, Nicholas D'Cunha, Donald P. Quick, Kyaw Zin Thein
Journal: Blood (2019)
Casein Kinase 1 Delta Is a Novel Regulator of mRNA Translation and Druggable Target in Aggressive Lymphomas
Authors: Ipsita Pal, Sohani Das Sharma, Andre M. Grilo, Prabhjot S. Mundi, Luigi Scotto, Abdullah Mahmood Ali, Luke E Berchowitz, Siddhartha Mukherjee, Owen O'Connor, Marko Jovanovic, Changchun Deng
Journal: Blood (2019)
ABO Blood Groups and Toxaemia of Pregnancy
Authors: L. A. Pike, A. M. Dickins
Journal: BMJ (1954)

BLOOD GROUPS AND PEPTIC ULCERATION DIALJURNAL 321 cancer of the bronchus.We have no data for cancer of the stomach.Making a number of comparisons, including a variety of further subdivisions, and also of additions, only one barely significant difference emerges.It was noted that in both sexes and in all three areas patients of group A with gastric ulcer were older than patients of group 0.Simple addition of the figures gave a difference of 1.64 years, 2.05 times its standard error.Simple addition is not ade- quate, but, using a method of weighting analogous to that used for the group comparisons, the result was unchanged.This difference, however, is only one arbitrarily selected out of many, and there is no confirmation in the figures for duodenal ulcer, nor in those of groups B and AB.The conclusion is, therefore, that, both in the disease which shows blood-group associations-peptic ulcer-and in the three giving a negative result, there is no evidence on these numbers of any difference in mean age between patients of the four groups.Table X shows mean ages with their standard errors .for the most important subdivisions.Summary Data are presented on the ABO blood-group frequen- cies amongst 3,011 patients with peptic ulcer, mainly those who have required treatment by transfusion and! or operation, 2,599 with cancer of the colon and rec- tum, 998 with cancer of the bronchus, and 1,017 with cancer of the breast.Compared with controls from the general population of the areas sampled, patients suffering from peptic ulcer show an increased incidence of group 0 and a corre- spondingly lower incidence of the other three groups.The difference is a large one.If our series is typical, persons of group 0 are about 35 % more likely to
Characteristics and Outcome of Patients with Core Binding Factor Acute Myeloid Leukemia and FLT3-ITD: Results from an International Collaboration
Authors: Sabine Kayser, Michelle A Elliott, Marlise Luskin, Andrew M. Brunner, Michael Kramer, Zdenek Racil, Zuzana Sustkova, Petr Cetkovsky, Jan Novak, Friedrich Stoelzel, Christian Thiede, Carsten Müller-Tidow, Uwe Platzbecker, Christoph Röllig, Richard F. Schlenk, Mark J. Levis
Journal: Blood (2019)
A Multi-Center Epidemiological and Prognostic Analysis of Cytogenetic Abnormalities in a Cohort of 1015 Chinese Patients with Newly-Diagnosed Multiple Myeloma
Authors: Fengyan Jin, Guangxun Gao, Yujun Dong, Chunrui Li, Wenrong Huang, Limo Zhang, Qiang Zhu, Ruifeng Yuan, Li Xu, Yanjie Xu, Qian Xu, Shaji K. Kumar, Yun Dai
Journal: Blood (2019)
Metabolic Syndrome Post Allogeneic STEM CELL Transplantation in Adult Patients Is NOT an Uncommon Complication. a Single Center Experience
Authors: Panayotis Kaloyannidis, Deia Awami, Solaf Kanfar, Zahra Abdrabalamir Alshammasi, Mohammed Darweesh, Enas Mutahar, Ahmed Bahrani, Rabab Attas, Heba Raslan, John Apostolidis, Khalid Ahmed Al-Anazi, Hani Al Hashmi
Journal: Blood (2019)
Conventional Chemotherapy Treatment Induces Unique Patterns of Clonal Evolution in a North American Adult T Cell Leukemia/Lymphoma Cohort
Authors: R. Alejandro Sica, Nishi Shah, Ana Acuna-Villaorduna, Nivetha Vishnuvardan, Urvi A Shah, Diego Adrianzen Herrera, Alyssa De Castro, Jennat Mustafa, Amanda Lombardo, Fariha Khatun, Latoya Townsend Nugent, Yanhua Wang, Olga Derman, Noah Kornblum, Ioannis Mantzaris, Lizamarie Bachier-Rodriguez, Aditi Shastri, Kira Gritsman, Ulrich G. Steidl, Ira Braunschweig, Amit Verma, Murali Janakiram, B. Hilda Ye
Journal: Blood (2019)
Tuberculosis in Developing Countries
Authors: N. Islam
Journal: BMJ (1964)

appears to have accentuated injury.Along with many others both the authors have worn safety-belts routinely for several years, and we have not experienced any of the inconveniences mentioned.Such matters, of course, vary from person to person-fortunately there are correspondingly several different designs of safety-harness to suit individual preferences.-Weare, etc.,