tbuckley/cabot-search huggingface dataset:
SP0169 New approach to the care of rheumatic patients within the project “patient partners”
Authors: M Dobesova
Journal: Annals of the Rheumatic Diseases (2001)

<h3></h3> New approaches to the care of rheumatic patients within the Project “Patients Partner”. An important component of the care of patients with a chronic rheumatic disease is a complex care and an individual approach. Rheumatism is generally thought of as a disease of elderly persons, although certain types of rheumatism attack also younger age groups. There are various topics that I feel deserve to be given attention to: Communication and information – the patient should learn communication skills and should receive a maximum of information about his disease and its treatment. Complex care and the importance of teamwork. Of importance is a good collaboration among the various specialists. The role of the nurse in providing complex care is indispensable. Establishment of national and international organisations of rheumatic patients – a good opportunity for meeting other patients, exchanging experience, giving advice about how to cope with pain. A good example is the Revma League in Prague and its branch at Bruntal. Social problems – equal rights for healthy and disabled persons (Public transport, abolishment of legal discrimination etc.).
Symptom Duration and Risk Factors for Delayed Return to Usual Health Among Outpatients with COVID-19 in a Multistate Health Care Systems Network — United States, March–June 2020
Authors: Mark W. Tenforde, Sara S. Kim, Christopher J. Lindsell, Erica Billig Rose, Nathan I. Shapiro, D. Clark Files, Kevin W. Gibbs, Heidi L. Erickson, Jay S. Steingrub, Howard A. Smithline, Michelle N. Gong, Michael S. Aboodi, Matthew C. Exline, Daniel J. Henning, Jennifer G. Wilson, Akram Khan, Nida Qadir, Samuel M. Brown, Ithan D. Peltan, Todd W. Rice, David N. Hager, Adit A. Ginde, William B. Stubblefield, Manish M. Patel, Wesley H. Self, Leora R. Feldstein, Kimberly W. Hart, Robert McClellan, Layne Dorough, Nicole Dzuris, Eric P. Griggs, Ahmed M. Kassem, Paula L. Marcet, Constance E. Ogokeh, Courtney N. Sciarratta, Akshita Siddula, Emily R. Smith, Michael J. Wu
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

Prolonged symptom duration and disability are common in adults hospitalized with severe coronavirus disease 2019 (COVID-19). Characterizing return to baseline health among outpatients with milder COVID-19 illness is important for understanding the full spectrum of COVID-19-associated illness and tailoring public health messaging, interventions, and policy. During April 15-June 25, 2020, telephone interviews were conducted with a random sample of adults aged ≥18 years who had a first positive reverse transcription-polymerase chain reaction (RT-PCR) test for SARS-CoV-2, the virus that causes COVID-19, at an outpatient visit at one of 14 U.S. academic health care systems in 13 states. Interviews were conducted 14-21 days after the test date. Respondents were asked about demographic characteristics, baseline chronic medical conditions, symptoms present at the time of testing, whether those symptoms had resolved by the interview date, and whether they had returned to their usual state of health at the time of interview. Among 292 respondents, 94% (274) reported experiencing one or more symptoms at the time of testing; 35% of these symptomatic respondents reported not having returned to their usual state of health by the date of the interview (median = 16 days from testing date), including 26% among those aged 18-34 years, 32% among those aged 35-49 years, and 47% among those aged ≥50 years. Among respondents reporting cough, fatigue, or shortness of breath at the time of testing, 43%, 35%, and 29%, respectively, continued to experience these symptoms at the time of the interview. These findings indicate that COVID-19 can result in prolonged illness even among persons with milder outpatient illness, including young adults. Effective public health messaging targeting these groups is warranted. Preventative measures, including social distancing, frequent handwashing, and the consistent and correct use of face coverings in public, should be strongly encouraged to slow the spread of SARS-CoV-2.
SAT0415 AGE RELATIONSHIP WITH ULTRASOUND ARTICULAR AND ENTHESEAL INVOLVEMENT IN PSORIATIC ARTHRITIS: CROSS-SECTIONAL STUDY
Authors: I. Fairushina, D. Abdulganieva, E. Kirillova, R. Abdrakipov
Journal: Annals of the Rheumatic Diseases (2020)

Background: Detection of subclinical enthesitis and synovitis in psoriatic arthritis (PsA) is prevalent and ultrasound (US) examination is informative tool for it diagnosing. Aging positively affects degenerative changes. Objectives: To study relationship between US articular and entheseal findings with age in patients with PsA. Methods: 57 patients were enrolled to study with fulfilled PsA criteria (CASPAR, 2009). Data collection: demographical, clinical (current psoriasis, axial involvement, enthesitis, dactylitis), US (synovitis count (by Grey Scale), Power Doppler(PD)+ synovitis), thickening and hypoechogenicity at enthesis, PD+ enthesitis, entheses with structural components); biological (high sensitive C-reactive protein (hsCRP), Erythrocyte Sedimentation Rate (ESR). US examination included 798 joints and 3078 entheses (bilateral shoulders, acromioclavicular joints, elbows, wrists, hips, knees, ankles; entheses at the projection of these joints (total number - 54). US entheseal findings were fixed according to consensus-based US definition and scoring for enthesitis in spondyloarthritis and PsA (OMERACT US) 1 . Results: In all 57 patients: male - 25 (43.9%), mean age 43.4±10.3(SD) years (y), PsA duration was 7 (3;10) y, Ps duration 10 (8; 22) y; 53 (41.1%) had axial involvement, 42 (73.7%) dactylitis, 8 (14%) clinical enthesitis, and 56 (98.2 %) skin psoriasis, Psoriasis Activity and Severity Index score 6.4 (2;14.4), Disease Activity in PsA score 18.1 (10.2;26.1), hsCRP 10.1(2.4;21.4), ESR 20 (11.3;31.5). Synovitis count increased with age noticeably (r=0.508, p&lt;0.01), and weak correlation of PD+ synovitis (r=0.262, p=0.049) and age was found. The entheseal thickening and hypoechogenicity and structural findings increased with age respectively (r=0.345, p=0.009; r=0.337, p=0.01). There was no correlation between PD+ enthesitis and age. The assosiation between PD+ enthesitis and blood biomarkers of inflammation (hs-CRP (r=0.364, p=0.008); ESR (p=0.358, p=0.008) was found. Conclusion: Our study found significant relationship between age and US synovitis. Association between age and US entheseal involvement was noted. Only PD+ enthesitis was not related with age in comparison with other US entheseal findings. The presence of PD US signal at enthesitis in association with increased inflammatory blood biomarkers can be evaluated as the sign of disease activity regardless of age and not as age-related lesion in PsA patients. References: [1]Balint PV, Terslev L, Aegerter P et al. Reliability of a consensus-based ultrasound definition and scoring for enthesitis in spondyloarthritis and psoriatic arthritis: an OMERACT US initiative. Ann Rheum Dis.;2018;77(12):1730-1735. Disclosure of Interests: None declared
A low-power band of neuronal spiking activity dominated by local single units improves the performance of brain–machine interfaces
Authors: Samuel R. Nason, Alex K. Vaskov, Matthew S. Willsey, Elissa J. Welle, Hyochan An, Philip P. Vu, Autumn J. Bullard, Chrono S. Nu, Jonathan C. Kao, Krishna V. Shenoy, Taekwang Jang, Hun-Seok Kim, David Blaauw, Parag G. Patil, Cynthia A. Chestek
Journal: Nature Biomedical Engineering (2020)
Integrating colocated behavioral health care into a dermatology clinic: A prospective randomized controlled treatment pilot study in patients with alopecia areata
Authors: Kristina Gorbatenko-Roth, James S. Hodges, Dayna Lifson, Maribeth Golm, Dory Kranz, Denise Windenburg, Maria Hordinsky
Journal: Journal of the American Academy of Dermatology (2020)
Abstract 368: A Cardiac Arrest Simulation-Based Feasibility Cadaver Study Investigating Time for Semi Surgical Cut Down Procedure Followed by Insertion of a Novel REBOA Catheter
Authors: Helene Duhem, Lionel Lamhaut, Alice Hutin, Alexandre Bellier, Stephane Tanguy, Francois Boucher, Philippe Chaffanjon, Guillaume Debaty
Journal: Circulation (2019)

Aim: Non-traumatic cardiac arrest is a major public health problem that carries an extremely high mortality rate. The Resuscitative endovascular balloon occlusion of the aorta (REBOA) procedure is currently being discussed as a possible technique to be used during Advanced Life Support (ALS) in humans with Cardiac arrest (CA). The aim of this study was to assess the training of emergency physicians in the procedures related to insertion of a novel REBOA catheter. Methods: We developed a training program using a simulated CA model on human cadavers. CPR was performed using the LUCAS device (Stryker/Jolife AB, Lund, Sweden). All cadavers were hemodynamically monitored. The Neurescue REBOA catheter (Neurescue REBOA device, Neurescue ApS, Copenhagen, Denmark) was inserted using a semi-surgical cut-down and sheath placement technique. Time needed to perform the procedures was measured. The procedures were instructed by 2 experts using video, procedural simulation on manikin and full-scale training on cadavers. Results: Six human cadavers were enrolled and a total of 12 procedures were performed by 2 expert investigators and 10 novice investigators. Eight semi-surgical cut-down producers including placements of the introducer sheath were performed on the first attempt and 4 required a second attempt. The median time required for the semi-surgical cutdown procedure and sheath placement by the novice investigators was: 6 min 48 sec (Min: 3 min 45 sec and Max: 26 min 25 sec). The median time required for the insertion and occlusion of the REBOA catheter by the novice investigators was: 3 min 22 sec (Min: 1 min 22 sec and Max: 7 min 5 sec). The median time required for full insertion for the novice investigators was: 11 min 14 sec (Min: 6 min 49 sec and Max: 28 min 15 sec). The mean aortic pressure during compression was: 31.9 mmHg (±17.0). Conclusions: Semi surgical cut-down and introducer sheath placement were performed in 1 or two 2 attempts for all novice investigators with an insertion time compatible with ALS during refractory CA. Simulation training on cadavers brings clinical realism and could be an important addition to the use of manikin or animal training models.
CHD4 Promotes Breast Cancer Progression as a Coactivator of Hypoxia-Inducible Factors
Authors: Yijie Wang, Yan Chen, Lei Bao, Bo Zhang, Jennifer E. Wang, Ashwani Kumar, Chao Xing, Yingfei Wang, Weibo Luo
Journal: Cancer Research (2020)

Recruitment of RNA polymerase II to hypoxia-inducible factor (HIF) target genes under normoxia is a prerequisite for HIF-mediated transactivation. However, the underlying mechanism of this recruitment remains unknown. Here we report that chromodomain helicase DNA-binding protein 4 (CHD4) physically interacts with α and β subunits of HIF1 and HIF2 and enhances HIF-driven transcriptional programs to promote breast cancer progression. Loss of HIF1/2α abolished CHD4-mediated breast tumor growth in mice. In breast cancer cells under normoxia, CHD4 enrichment at HIF target gene promoters increased RNA polymerase II loading through p300. Hypoxia further promoted CHD4 binding to the chromatin via HIF1/2α, where CHD4 in turn enhanced recruitment of HIF1α, leading to HIF target gene transcription. CHD4 was upregulated and correlated with HIF target gene expression in human breast tumors; upregulation of CHD4 and other known HIF coactivators in human breast tumors was mutually exclusive. Furthermore, CHD4 was associated with poor overall survival of patients with breast cancer. Collectively, these findings reveal a new fundamental mechanism of HIF regulation in breast cancer, which has clinical relevance. SIGNIFICANCE: This study identifies CHD4 as a HIF coactivator and elucidates the fundamental mechanism underlying CHD4-mediated HIF transactivation in breast tumors.
Health Disparities in Advanced Heart Failure Treatment
Authors: Bessie A. Young
Journal: JAMA Network Open (2020)

Khadijah Breathett, MD, MS; Erika Yee, BS; Natalie Pool, PhD, RN; Megan Hebdon, PhD, DNP, RN; Janice D. Crist, PhD, RN; Ryan H. Yee, BS; Shannon M. Knapp, PhD; Sade Solola, MD; Luis Luy; Kathryn Herrera-Theut, BS; Leanne Zabala, MD; Jeff Stone, PhD; Marylyn M. McEwen, PhD, RN; Elizabeth Calhoun, PhD; Nancy K. Sweitzer, MD, PhD
SAT0220 BIOLOGICAL PREDICTORS OF ECHOGRAPHIC SALIVARY GLAND INVOLVEMENT SEVERITY IN PATIENTS WITH SJÖGREN’S SYNDROME
Authors: A. Mihai, D. Mardale, D. Opris-Belinski, R. Ionescu, C. Jurcut
Journal: Annals of the Rheumatic Diseases (2020)

Background: Echographic evaluation of salivary gland increasingly became a routine imaging modality in patients with Sjogren’s syndrome (SS). However, predictive parameters associated with the severity of echographic features are still incomplete evaluated. Objectives: The aim of this study was to evaluate the predictors for severe echographic involvement in patients with SS followed in a tertiary center. Methods: We included 63 patients with SS (mean age: 52.3±11.9; 59 female). The complete laboratory workup, clinical manifestations and treatment were reviewed and the EULAR Sjögren’s syndrome disease activity index (ESSDAI) was calculated for each patients. We performed the standard echographic evaluation of salivary gland in all patients and used a 4 grade system for severity staging. Results: The distribution of echographic grade was: no any echographic features – 4 pts (6.3%); grade 1 - 24 pts (38.1%); grade 2 – 20 pts (31.7%); grade 3 – 10 pts (15.9%); grade 4 – 5 pts (7.9%). The ESSDAI and the hydroxichloroquine use were similar in these subgroups. We didn’t find differences regarding CRP and fibrinogen and echographic features. The age of the patients, the anti-SSA and anti-SSB, ESR, total protein, IgA, IgG and rheumatoid factor levels were significantly higher and lymphocyte count was lower in patients with echographic severity above grade 2 when compared with patients with no or mild echographic features. However, using ANOVA test and post-hoc analysis, the only parameters associated with the severity of echographic features were high ESR (53 vs 17 in grade 4 vs 1, p=0.02), IgA (363 vs 190 in grade 4 vs 1, p=0.004) and IgG (1985 vs 1191 U/l in grade 4 vs 1, p=0.001) levels. Conclusion: Parameters linked to polyclonal hypergammaglobulinemia (IgA and IgG levels; and ESR) seem to be linked to the severity of echographic appearance of salivary gland in patients with SS. Further studies are needed in order to better characterize this link. Disclosure of Interests: Ancuta MIHAI: None declared, DENISE MARDALE: None declared, Daniela Opris-Belinski Speakers bureau: as declared, Ruxandra Ionescu Consultant of: Consulting fees from Abbvie, Eli-Lilly, Novartis, Pfizer, Roche, Sandoz, Speakers bureau: Consulting and speaker fees from Abbvie, Eli-Lilly, Novartis, Pfizer, Roche, Sandoz, Ciprian Jurcut: None declared
Abstract 120: Effects of Therapeutic Hypothermia on Blood Parameters in Rats With Acute Hemorrhagic Shock
Authors: Jianru Shi, Wangde Dai, Juan Carreno, Sharon L Hale, Robert A Kloner
Journal: Circulation (2019)

Background: Our research group recently observed that therapeutic hypothermia (TH) compared with normothermia improved long-term survival in an experimental model of hemorrhagic shock. The effect of TH on blood counts, blood gases and chemistries during the early phase of recovery from hemorrhagic shock are unknown. Therefore, the purpose of the present study was to examine the effects of TH on blood parameters in the early phase of resuscitation from hemorrhagic shock. Methods and results: Sprague Dawley rats (both genders) were randomly assigned to TH (n= 16) or normothermia group (n= 15). Rats were anesthetized with intraperitoneal ketamine and xylazine. After heparinizing, hemorrhagic shock was induced by withdrawing blood to a fixed mean blood pressure (MBP) of 30 mmHg for 30 minutes and then shed blood was reinfused. TH was started 5 minutes after MBP reached 30 mmHg. Core temperature was maintained at ~ 32 °C until blood volume was fully restored, after which the rats were allowed to warm back to normal temperature. In the normothermia group, body temperature was maintained at ~ 37°C. Arterial blood samples were collected 1 hour after resuscitation with shed blood. We found that pO2 (partial pressure of oxygen) was significantly higher in TH group versus the normothermic group. The rats in normothermic group had significantly elevated potassium, chloride and lactate levels and more negative base excess compared to rats that in TH group (Table). The neutrophil was lower in the TH group; the lymphocyte (%) was higher in the TH group. There were no significantly differences in pH, pCO2, sodium, calcium or glucose between the normothermia and TH groups. Conclusions: pO2 remained normal and levels of potassium, chloride, lactate and neutrophil were lower in TH group. These results may contribute to the protective effect of TH during hemorrhagic shock.
Differential toll like receptor expression in cystic fibrosis patients' airways during rhinovirus infection
Authors: Carolina Scagnolari, Camilla Bitossi, Federica Frasca, Agnese Viscido, Gabriele Brazzini, Maria Trancassini, Valeria Pietropaolo, Fabio Midulla, Giuseppe Cimino, Paolo Palange, Alessandra Pierangeli, Guido Antonelli
Journal: Journal of Infection (2020)
Antecedent immunosuppressive therapy for immune-mediated inflammatory diseases in the setting of a COVID-19 outbreak
Authors: Jesse Veenstra, Connor R. Buechler, Gabrielle Robinson, Stephanie Chapman, Madeline Adelman, Aaron Tisack, Peter Dimitrion, Erika Todter, Laurie Kohen, Henry W. Lim
Journal: Journal of the American Academy of Dermatology (2020)
Reopening Economies during the COVID-19 Pandemic: Reasoning about Value Tradeoffs
Authors: Hon-Lam Li, Nancy S. Jecker, Roger Yat-Nork Chung
Journal: The American Journal of Bioethics (2020)

As societies around the globe struggle with decisions to lift lockdowns and reopen economies amid the coronavirus (COVID-19) pandemic, controversy over the risks of reopening are fraught. The choic...
ATF6 aggravates acinar cell apoptosis and injury by regulating p53/AIFM2 transcription in Severe Acute Pancreatitis
Authors: Jie-Hui Tan, Rong-Chang Cao, Lei Zhou, Zhi-Tao Zhou, Huo-Ji Chen, Jia Xu, Xue-Mei Chen, Yang-Chen Jin, Jia-Yu Lin, Jun-Ling Zeng, Shu-Ji Li, Min Luo, Guo-Dong Hu, Xiao-Bing Yang, Jin Jin, Guo-Wei Zhang
Journal: Theranostics (2020)

Background: There is no curative therapy for severe acute pancreatitis (SAP) due to poor understanding of its molecular mechanisms. Endoplasmic reticulum (ER) stress is involved in SAP and increased expression of ATF6 has been detected in SAP patients. Here, we aimed to investigate the role of ATF6 in a preclinical SAP mouse model and characterize its regulatory mechanism. Methods: Pancreatic tissues of healthy and SAP patients were collected during surgery. Humanized PRSS1 transgenic mice were treated with caerulein to mimic the SAP development, which was crossed to an ATF6 knockout mouse line, and pancreatic tissues from the resulting pups were screened by proteomics. Adenovirus-mediated delivery to the pancreas of SAP mice was used for shRNA-based knockdown or overexpression. The potential functions and mechanisms of ATF6 were clarified by immunofluorescence, immunoelectron microscopy, Western blotting, qRT-PCR, ChIP-qPCR and luciferase reporter assay. Results: Increased expression of ATF6 was associated with elevated apoptosis, ER and mitochondrial disorder in pancreatic tissues from SAP patients and PRSS1 mice. Knockout of ATF6 in SAP mice attenuated acinar injury, apoptosis and ER disorder. AIFM2, known as a p53 target gene, was identified as a downstream regulatory partner of ATF6, whose expression was increased in SAP. Functionally, AIFM2 could reestablish the pathological disorder in SAP tissues in the absence of ATF6. p53 expression was also increased in SAP mice, which was downregulated by ATF6 knockout. p53 knockout significantly suppressed acinar apoptosis and injury in SAP model. Mechanistically, ATF6 promoted AIFM2 transcription by binding to p53 and AIFM2 promoters. Conclusion: These results reveal that ATF6/p53/AIFM2 pathway plays a critical role in acinar apoptosis during SAP progression, highlighting novel therapeutic target molecules for SAP.
THU0154 Atlantoaxial disorders in rheumatoid arthritis associate with destructions of the peripheral and shoulder joints, and decreased bone mineral density
Authors: MH Neva, A Kotaniemi, K Kaarela, JT Lehtinen, P Isomäki, EA Belt, H Kautiainen, M Kauppi
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> Anterior atlantoaxial subluxation (aAAS) and atlantoaxial impaction (AAI) are common cervical spine disorders in advanced rheumatoid arthritis (RA;1). Earlier studies have suggested the association of the cervical spine disorders with peripheral joint destruction and osteoporosis of the cervical spine. <h3>Objectives</h3> To evaluate whether atlantoaxial disorders (aAAS and AAI) associate with destruction of shoulder- (glenohumeral [GH] or acromioclavicular [AC]) or peripheral joints, and bone mineral density (BMD) in patients who have suffered RA for 20-years. <h3>Methods</h3> An inception cohort of 103 patients with rheumatoid factor (RF) positive RA were followed up for 20 years, a total of 68 patients attended the 20-year check-up.<sup>1</sup> The shoulder radiographs were taken at the 15-year examination, and the cervical spine, hand and foot radiographs at the 20-year follow-up. Moreover, the BMD of the lumbar spine and femoral neck were measured at the 20-year check-up. Thereafter, the occurrence and severity of atlantoaxial disorders were compared with the Larsen scores of peripheral and shoulder (GH and AC) joints, and with BMD of the lumbar spine and femoral neck. <h3>Results</h3> A positive relationship was detected between the occurrence of atlantoaxial disorders and the destruction of both shoulder (p &lt; 0.001) and peripheral (p = 0.001) joints. In addition, the extent of aAAS and the severity of AAI correlated positively with the grade of destruction in the evaluated joints. Furthermore, a positive relationship was found between the occurrence of the atlantoaxial disorders and a decrease in BMD of the lumbar spine (p = 0.13) and femoral neck (p = 0.019). <h3>Conclusion</h3> Patients with severe RA have an increased risk for atlantoaxial disorders, and the co-existence of shoulder and cervical spine disorders makes the differential diagnosis of shoulder and neck pain challenging. In addition, osteoporosis may increase the risk for severe complications caused by cervical spine disorders in patients with RA. <h3>Reference</h3> Neva MH, Kaarela K, Kauppi M. Prevalence of radiological changes in the cervical spine – a cross-sectional study after 20 years from presentation of rheumatoid arthritis. J Rheumatol. 2000;27:90–3
Abstract 10032: Novel TMEM168 Gene Mutation in Brugada Syndrome Impairs Sodium Channel Function via the Nav1.5 Degradation
Authors: Hisakazu Ogita, Dimitar P Zankov, Akio Shimzu
Journal: Circulation (2019)

Brugada syndrome (BrS) is characterized by the typical electrocardiographic pattern in the right precordial leads, and often causes malignant ventricular tachyarrhythmias that may lead to sudden ca...
A Novel Approach Using Social Media to Solve Medical Ethical Dilemmas and Legal Risks in the Emergencies of COVID-19
Authors: Jing Wan, Yuqiong Huang, Amaneh Abdel Hafez A. Aljaafreh, Dandan Dong, Yali Cong, Jun Lin, Hongxiang Chen
Journal: The American Journal of Bioethics (2020)

COVID-19 is an emerging infectious disease that is extremely contagious and can cause serious consequences and even death.Convalescent plasma, an unregistered therapy, from which the antibodies mig...