tbuckley/cabot-search huggingface dataset:
Active Immune Thrombocytopenia (ITP) Disease Is Characterised By a Reduced Treg:CD8 Effector T Cell Ratio Which Is Modulated By Thrombopoietin-Receptor Agonists (TPO-RA)
Authors: Anwar A. Sayed, Amna Malik, Ahmad Khoder, George Adams, Nichola Cooper
Journal: Blood (2018)
SAT0039 Ll37 up-regulation and anti-ll37 reactivity are shared by psoriasis and psoriatic arthritis patients
Authors: L. Frasca, R. Palazzo, M.S. Chimenti, E. Botti, S.E. Auteri, F. Spadaro, S. Alivernini, B. Tolusso, E. Gremese, B. Marinari, I. Pietraforte, F.R. spinelli, G.L. Fonti, T. Colasanti, C. Alessandri, F. Conti, A. Costanzo, L. Bianchi, G. Valesini, R. Perricone, R. Lande
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> The antimicrobial peptide LL37 plays a pathogenic role in psoriasis (Pso) due to its adjuvant and auto-antigenic properties. At least a third of Pso patients develop psoriatic arthritis (PsA) but mechanisms that lead PsA development in Pso patients remain elusive. <h3>Objectives</h3> To understand the role of LL37 in PsA pathogenesis and its relationship with inflammatory molecules IFNa, GMCSF, C5a. <h3>Methods</h3> Blood samples were collected from 32 biologic-naïve PsA, 12 active Pso (without PsA) patients and 8 healthy donors (HD). Synovial fluids (SF) were collected from 17 PsA and 12 osteohartritis (OA) patients. Synovial biopsies from 3 biologic-naïve PsA patients were studied by confocal microscopy. Native-LL37 was synthesised and carbamylated LL37 (LL37carb) produced by incubating LL37 with 1 M potassium cyanate and verified by dot-blot assay. Antibodies to native-LL37/LL37carb and levels of LL37, GMCSF, IFNa and complement C5a were measured by in-house and commercial ELISA tests, respectively, in SF and plasma. <h3>Results</h3> High LL37 levels were detectable in SF of PsA compared to OA. Anti-LL37 [24% in SF (4/17)] and anti-LL37carb antibodies [47% in SF (8/17), 46% in plasma (15/32)] were present in PsA but not in OA and HD. Anti-LL37carb antibodies [41% (5/12)] were also detectable in Pso plasma. IFNa was present in 37% of SF PsA (7/16; not detectable in OA) and correlated with C-reactive Protein (CRP); GMCSF and C5a levels were significantly higher in SF PsA than in SF OA. Notably, GMCSF was also detectable in 40% and 30% of PsA and Pso plasma, respectively, but not in HD; Plasma C5a levels were comparable between PsA and Pso and significantly higher than in HD. SF GMCSF correlated with anti-LL37carb autoantibodies. Anti-LL37carb antibodies correlated with levels of C5a in Pso and PsA plasma. In synovial tissues of PsA the expression of the IFN-related gene MX1 was highly up-regulated in close proximity of neutrophil markers myeloperoxidase and LL37. <h3>Conclusions</h3> LL37 and, in particular, LL37carb is the target of autoantibodies that correlate with pro-inflammatory GMCSF and C5a in both Pso and PsA, suggesting immunological pathways in common between psoriasis and psoriatic arthritis. <h3>Reference</h3> ] Lande R, et al. Nature 2007;449:564. ] Lande R, et al. Sci Transl Med 2011;3(73):73ra19. [] Lande R, et al. Nat Commun2014;5:5621. [] Chimenti MS, et al. Autoimmun Rev2015;14(12):1142. <h3>Disclosure of Interest</h3> None declared
Toxicity Profile of Brentuximab Vedotin in Combination with Chemotherapy for Newly Diagnosed Patients with ALK+ ALCL: A Children's Oncology Group Study ANHL12P1
Authors: Eric J Lowe, Anne Reilly, Catherine M. Bollard, Donald A Barkauskas, Allen B Buxton, David Hall, Lauren Saguilig, John T. Sandlund
Journal: Blood (2018)
Repurposing Leflunomide for Relapsed/Refractory Multiple Myeloma: Final Analysis of a Phase 1 Study
Authors: Michael Rosenzweig, Joycelynne Palmer, Ni-Chun Tsai, Ralf Buettner, Lupe Duarte, Myo Htut, Chatchada Karanes, Nitya Nathwani, Flavia Pichiorri, Firoozeh Sahebi, Tim Synold, Xiwei Wu, James F Sanchez, Amrita Krishnan, Stephen J Forman, Steven T Rosen
Journal: Blood (2018)
Association of Maternal Social Relationships With Cognitive Development in Early Childhood
Authors: Eun Kyong Shin, Kaja LeWinn, Nicole Bush, Frances A. Tylavsky, Robert Lowell Davis, Arash Shaban-Nejad
Journal: JAMA Network Open (2019)

<h3>Importance</h3> This study examines how different types of social network structures are associated with early cognitive development in children. <h3>Objectives</h3> To assess how social relationships and structures are associated with early cognitive development and to elucidate whether variations in the mother's social networks alter a child's early cognitive development patterns. <h3>Design, Setting, and Participants</h3> This cohort study used data from 1082 mother-child pairs in the University of Tennessee Health Science Center–Conditions Affecting Neurocognitive Development and Learning and Early Childhood project to examine the association between networks of different levels of complexity (triad, family, and neighborhood) and child cognitive performance after adjustment for the mother's IQ, birth weight, and age, and the father's educational level. The final model was adjusted for the household poverty level. Data were collected from December 2006 through January 2014 and analyzed from October through November 2018. <h3>Exposures</h3> The child-mother relationship, child-mother-father triad, family setting, child's dwelling network, mother's social support network, and neighborhood networks. <h3>Main Outcomes and Measures</h3> Measure of cognitive development of the child using Bayley Scales of Infant Development (BSID) at 2 years of age. <h3>Results</h3> Of 1082 participants, 544 (50.3%) were males and 703 (65.1%) were African American; the mean (SD) age was 2.08 (0.12) years. Large family size had a negative association with early cognitive development, with a mean 2.21-point decrease in BSID coefficient score (95% CI, 0.40 to 4.02;<i>P</i> = .01). Mother's social support network size was positively associated early cognitive development, with a mean 0.40-point increase in BSID coefficient score (95% CI, 0.001 to 0.80;<i>P</i> = .05). Knowing many neighbors was not statistically significantly associated with early cognitive development, with a mean 1.39-point increase in BSID coefficient score (95% CI, −0.04 to 2.83;<i>P</i> = .06). <h3>Conclusions and Relevance</h3> The findings suggest that maternal social relationships are associated with cognitive development in children and that social relationships beyond the mother-child-father triad are significantly associated with children's cognitive development. This study investigates the environmental influences on child health outcomes and, specifically, how early cognitive development is associated with social networks for the primary caregiver.
AB0530 Treatment outcome in lupus nephritis patients treated with mycophenolate mofetil: from real-world clinical practice
Authors: S.M. Jung, D. Kim, H.W. Kim, S.-W. Lee, J.J. Song, Y.-B. Park
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Systemic lupus erythematosus (SLE) is a systemic autoimmune disease often characterised by the development of glomerulonephritis.<sup>1</sup> There is a growing interest in the use of mycophenolate mofetil (MMF) as induction therapy and maintenance therapy for lupus nephritis.<sup>2, 3</sup> <h3>Objectives</h3> This study aimed to evaluate the therapeutic outcome of MMF in lupus nephritis from real-world clinical practice, and identify the predictors for failure of remission after MMF treatment. <h3>Methods</h3> Korean patients with pathologically proven lupus nephritis class III, IV, and V were recruited from rheumatology clinic in Severance Hospital, Yonsei University College of Medicine between Nov 2011 and Aug 2017 Patients who treated with MMF for at least 3 months were included in the analysis. The probability of remission after MMF therapy, and the difference between patients who achieved remission or failed to achieve remission were analysed using Kaplan-Meier analysis and Cox proportional hazards model. <h3>Results</h3> Of 153 patients with lupus nephritis, 116 patients were included in this study. Seventy two patients continued MMF until the last follow-up. The mean age of patients was 34.2 years, and the median duration of SLE was 5.7 months. Anti-dsDNA antibody was positive in 82.8% of patients, and 9.5% of patients showed a histological class with pure V pathology. Mean protein/creatinine ratio in spot urine was 4.6, and active urinary sediment was found in 82.8% of patients. During median follow-up period of 5 years, 80% of patients achieved clinical remission of lupus nephritis. Median time to remission was 4.2 months (IQR 0.9–9.1). Risk factors for failure of remission were nephrotic-range proteinuria and seronegativity of anti-dsDNA antibodies. <h3>Conclusions</h3> This study shows the real-world data on MMF treatment in patients with lupus nephritis. Patients with risk factors for failure to remission may require more intensive treatment and management. <h3>References</h3> [1] Yu F, Haas M, Glassock R, Zhao MH. Redefining lupus nephritis: clinical implications of pathophysiologic subtypes, Nature reviews. Nephrology13 (2017) 483–495. [2] Ginzler EM, Dooley MA, Aranow C, Kim MY, Buyon J, Merrill JT, et al. Mycophenolate mofetil or intravenous cyclophosphamide for lupus nephritis. The New England journal of medicine2005;353(2005):2219–2228. [3] Dooley MA, Jayne D, Ginzler EM, Isenberg D, Olsen NJ, Wofsy D, et al. Mycophenolate versus azathioprine as maintenance therapy for lupus nephritis. The New England journal of medicine2011;365(2011):1886–1895. <h3>Acknowledgements</h3> None <h3>Disclosure of Interest</h3> None declared
Factors Associated with Early Therapy Initiation in Patients (pts) with Myelodysplastic Syndromes (MDS) in the Connect® MDS/AML Disease Registry
Authors: Christopher R. Cogle, Guillermo Garcia-Manero, David L. Grinblatt, Rami S. Komrokji, Michael R. Savona, Bart L. Scott, Mikkael A. Sekeres, Chrystal U. Louis, E. Dawn Flick, Melissa Nifenecker, Pavel Kiselev, Arlene S. Swern, David P. Steensma
Journal: Blood (2018)
Abstract 358: Factor Xa Deteriorates Atherosclerosis by Facilitating Inflammasome Formation via PAR-2-mediated Autophagy Suppression
Authors: Yasuhiro Maejima, Yusuke Ito, Natsuko Tamura, Masanori Konishi, Kenzo Hirao, Mitsuaki Isobe
Journal: Circulation Research (2017)

Background: It is known that an endogenous blood coagulation factor Xa (FXa) plays a critical role in facilitating atherosclerosis by activating protease-activated receptor-2 (PAR-2). However, the precise mechanism how FXa-mediated PAR-2 activation promotes atherogenesis remains to be elucidated. Purpose: The aim of this study is to explore how FXa promotes atherosclerosis through PAR-2-associated signaling pathway. Methods &amp; Results: Administration of direct FXa inhibitor rivaroxaban (Riv; 120 mg/kg/day) to the mice significantly suppressed the plasma FXa activity compared with untreated mice. Administration of Riv to ApoE knockout mice fed with high fat diet (ApoE-KO-HFD) significantly reduced atherosclerotic area in the aorta compared with those in the untreated ApoE-KO-HFD. The plaque size of ApoE-KO mice crossed with PAR-2 knockout mice fed with HFD was similar to those of Riv-treated ApoE-KO-HFD. Ultrastructural examinations of atherosclerotic lesions revealed that the number of autophagosomes in the plaque-resident macrophages of Riv-treated ApoE-KO-HFD was significantly smaller than those of the untreated ApoE-KO-HFD. Immunostaining of NLRP3 revealed that Riv attenuated the inflammasome formation in the atherosclerotic lesion in ApoE-KO-HFD. In vitro experiments demonstrated that treatment of 7-ketocholesterol (7KC) markedly enhanced autophagy activity in the murine macrophages. The addition of FXa significantly promoted mTOR (Ser 2448 ) phosphorylation and blocked autophagy activity induced by 7KC, which was reversed in the presence of Riv (1 μM). Furthermore, immunoblot analyses demonstrated that FXa administration significantly accelerated inflammasome formation induced by 7KC, which was blocked in the presence of Riv. On the other hand, treatment with FXa failed to inhibit 7KC-induced autophagy and inflammasome activation in PAR-2-KO mice-derived macrophages. Conclusion: These results suggest that FXa worsens atherogenesis through PAR-2-mediated pathway by inhibiting macrophage autophagy which, in turn, promoting inflammasome activation.
Abstract 18321: Serum Cardiac Myosin Binding Protein-C Correlates With Severity of Overall Cardiovascular Stress
Authors: Carl W Tong, Dustin Johnson, Lisa DeLaRosa, Giuseppina Dusio, Suresh Govindan, Paola Rosas, Yang Liu, Jeffrey Michel, Jerome Trzeciakowski, Sakthivel Sadayappan
Journal: Circulation (2017)

Introduction: Cardiac Myosin Binding Protein-C (cMyBP-C) is a heart muscle thick filament protein that regulates contractility and lusitropy. Significant serum cMyBP-C levels occur independent of m...
Efficacy of Combined Ruxolitinib and Decitabine in Patients with Accelerated and Blast-Phase Myeloproliferative Neoplasms: Results of a Phase II Study (MPN-RC 109 trial)
Authors: Raajit K. Rampal, John Mascarenhas, Heidi E. Kosiorek, Rupali Bhave, Elizabeth O. Hexner, Eunice S. Wang, Aaron T. Gerds, Mark L Heaney, Camille N Abboud, Marina Kremyanskaya, Dmitriy Berenzon, Olatoyosi Odenike, Elizabeth Virtgaym, Lonette Sandy, Rona Singer Weinberg, Vesna Najfeld, Mohamed E. Salama, Ross L. Levine, Ruben A. Mesa, Amylou C. Dueck, Ronald Hoffman
Journal: Blood (2018)
Abstract 14102: Hydrochlorothiazide and Alternative Diuretics versus Renin-Angiotensin System Inhibitors for the Regression of Left Ventricular Hypertrophy: A Head-to-Head Meta-Analysis
Authors: Steven Song, Ramy Abdelfattah, John B Kostis, Michael E Ernst, Domenic A Sica, George C Roush
Journal: Circulation (2017)

Found in 36%-41% of hypertensive patients, left ventricular hypertrophy (LVH) independently predicts cardiovascular events and total mortality. Conversely, drug-induced LVH regression predicts impr...
Abstract 17888: Catastrophic Health Expenditures: A Financial Adverse Effect of Coronary Artery Bypass Grafting in the Uninsured
Authors: Jonathan C Hong, Rohan Khera, Anshul Saxena, Alejandro Arrieta, Salim S Virani, Ron Blankstein, Glenn J Whitman, Harlan M Krumholz, Khurram Nasir
Journal: Circulation (2017)

Background: Coronary artery bypass grafting (CABG) can be an unanticipated major healthcare event that requires costly treatment. We sought to evaluate the risk of catastrophic healthcare expenditures (CHE) among uninsured adults in the United States prior to the insurance protections from the Affordable Care Act (ACA). Methods: In the National Inpatient Sample (2008-2012), we conducted a retrospective review of all CABG hospitalizations among uninsured non-elderly adults ages 18-64. CHE was defined as hospitalization costs that exceeded 40% of a post-subsistence income. Patient-level income was determined by randomly drawing from gamma distributions using data from the US Census. Subsistence costs were estimated from the US Bureau of Labor Statistics. The bootstrapped mean and 95% confidence interval were determined by repeating the analysis 10,000 times. Predictors of CHE were identified using multivariable logistic regression. Results: There were 9,174 hospitalizations for uninsured patients undergoing...
Risk of Diabetes Associated With Cancer Development—In Reply
Authors: Juhee Cho, Danbee Kang, Yul Hwangbo, Eliseo Guallar
Journal: JAMA Oncology (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Investigating Potential Bias in Patient-Reported Outcomes in Open-label Cancer Trials
Authors: Jessica K. Roydhouse, Mallorie H. Fiero, Paul G. Kluetz
Journal: JAMA Oncology (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Combination of Lenalidomide and Rituximab in Patients with Treatment-Naïve and Relapsed Chronic Lymphocytic Leukemia: Treatment Results and Predictive Factors of Response
Authors: Paolo Strati, Koichi Takahashi, Michael J. Keating, Philip A. Thompson, Christina Hinojosa, Diana Rodriguez, Naval G. Daver, Nitin Jain, Jan A. Burger, Zeev E. Estrov, Susan M. O'Brien, Hagop M. Kantarjian, William G. Wierda, Andrew Futreal, Alessandra Ferrajoli
Journal: Blood (2018)
Abstract 14894: A Shocking Deficiency: An Unusual Case of Rapidly Progressive Pulmonary Hypertension
Authors: Nicholas A Marston, Erin Penn, Benjamin A Olenchock
Journal: Circulation (2017)

A 48-year-old woman presented with rapidly progressive chest pain and dyspnea. Over the past year she had experienced recurrent pericarditis, joint pain, and rash. Transthoracic echocardiogram show...
AB0560 Patients with rheumatoid arthritis and lupus have similar prevalence of periodontitis – a cross-sectional survey
Authors: C. Ciurtin, M. Orlandi, J. Bakshi, J. Guinto, B. Bernstein, F. D’Aiuto
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Periodontitis (PD) is a chronic inflammatory disease of the gingival tissues triggered by a dysbiotic microflora and causing the loss of soft and hard tissues surrounding the dentition. Over the last two decades, PD has been linked to a systemic inflammatory response and an increased risk of other comorbidities including cardiovascular diseases and diabetes. Numerous observational studies have confirmed an association between PD and rheumatic diseases. Some evidence suggests an association with rheumatoid arthritis (RA) and a beneficial effect of periodontal treatment on RA outcomes. Scarce evidence instead exists on the association between PD and Systemic Lupus Erythematosus (SLE). The main aim of this study was to evaluate the prevalence of PD in RA and SLE. <h3>Methods</h3> We conducted a cross-sectional survey of consecutive eligible outpatients with RA and SLE attending the Rheumatology Department at UCLH. PD diagnosis was estimated administering a validated self-reported questionnaire. Medical histories, cardiometabolic risk factors and assessment of standard biomarkers of inflammation and RA activity were collected as part of the outpatients' visit. <h3>Results</h3> 86 patients affected by RA and 122 by SLE and 5 presenting both diseases were recruited and agreed to complete the questionnaire. PD was detected in 100 patients of the overall survey (47%). 38 (44%) patients with RA and 59 (48%) patients with SLE had prevalent PD. There was no statistically significant difference in the prevalence of PD between the two patients' groups (p=0.575). PD was associated with diagnosis of diabetes (p=0.023), hypertension (p=0.004) and hypercholesterolemia (p&lt;0.0001). Diagnosis of PD was associated with increased levels of C-reactive protein (CRP) (2.8±3.3 vs 4.0±4.4, p=0.03) in the whole population. In RA patients PD was associated with increased CRP (3.2±3.2 vs 5.2±4.4, p=0.014) and ESR (9.8±10.0 vs 18.3±16.6, p=0.008). <h3>Conclusions</h3> Prevalence of PD is similar in both RA and SLE (approximately 45%) and to the UK national estimates (Adult Dental Survey 2009). PD could contribute to an increased inflammatory profile in patients with RA and SLE. Our data highlight the need of assessing oral health needs of patients with rheumatic diseases. <h3>Disclosure of Interest</h3> None declared
AB0982 Prevalence of osteoarthritis in high altitude area of tibet
Authors: Y. Liang, Y. Mei, S. Guan, W. Sun, W. Wang, F. Teng, X. Han, Z. Zhang
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Osteoarthritis is a degenerative joint disease; the specific etiology and pathogenesis are unclear. The prevalence of osteoarthritis of subtypes of joints is different, whereas the most common osteoarthritis occurs in knees. In China, the prevalence of osteoarthritis is about 15%, the prevalence of the patients over 40 years old is 10%~17%, and 50% over the age of 60, while over 75 years old was as high as 80%. Few data exist regarding the prevalence of OA in plateau in China. <h3>Objectives</h3> To investigate the prevalence of osteoarthritis(OA) in Jiuhe village, which is located about 3.5 kilometres high of Qonggyai County of Tibet and the associated factors in order to provide the guidance for the prevention and treatment of OA. <h3>Methods</h3> The participants in this analysis were all the resident people aged 50 years and above in Jiuhe village, Qonggyai County of Tibet. All subjects were invited to completed an questionnaire, physical examination and radiographic examination. The questionnaire included sex, age, body mass index(BMI) and dietary habit. <h3>Results</h3> A total of 136 participants aged 50–86 years were enrolled, including 47 males with mean age of 62.00±9.11 years, and 89 females with mean age of 61.30±9.52 years. Altogether 102 knee OA can be diagnosed, the total prevalence of knee OA was 75.00%. Knee OA occurred in 78.72% of male and 73.03% of female. The prevalence of knee OA combined with hand OA was 19.12%, and 21.28% for male and 17.98% for female. The prevalence of knee OA combined with hand OA increased with age in the female, no such trend was observed in male or in only knee OA patients. No significant difference was found about sex, BMI, drinking between the OA patients and the controls. <h3>Conclusions</h3> The prevalence of osteoarthritis in Jiuhe village, plateau of Tibet was significantly high. The prevalence in male is higher than that in female. The prevalence of knee OA combined with hand OA increased with age in the female. <h3>Acknowledgements</h3> Create China Hearts Foundation <h3>Disclosure of Interest</h3> None declared