tbuckley/cabot-search huggingface dataset:
Nutritional Aspects of Spermidine
Authors: Frank Madeo, Sebastian J. Hofer, Tobias Pendl, Maria A. Bauer, Tobias Eisenberg, Didac Carmona-Gutierrez, Guido Kroemer
Journal: Annual Review of Nutrition (2020)

Natural polyamines (spermidine and spermine) are small, positively charged molecules that are ubiquitously found within organisms and cells. They exert numerous (intra)cellular functions and have been implicated to protect against several age-related diseases. Although polyamine levels decline in a complex age-dependent, tissue-, and cell type-specific manner, they are maintained in healthy nonagenarians and centenarians. Increased polyamine levels, including through enhanced dietary intake, have been consistently linked to improved health and reduced overall mortality. In preclinical models, dietary supplementation with spermidine prolongs life span and health span. In this review, we highlight salient aspects of nutritional polyamine intake and summarize the current knowledge of organismal and cellular uptake and distribution of dietary (and gastrointestinal) polyamines and their impact on human health. We further summarize clinical and epidemiological studies of dietary polyamines.
NCCN Policy Summit: Defining, Measuring, and Applying Quality in an Evolving Health Policy Landscape and the Implications for Cancer Care
Authors: Lindsey A.M. Bandini, Leigh Gallo, Terrell Johnson, Kara Martin, Alyssa A. Schatz, Kerin Adelson, Bryan A. Loy, Ronald S. Walters, Tracy Wong, Robert W. Carlson
Journal: Journal of the National Comprehensive Cancer Network (2020)

Quality measurement is a critical component of advancing a health system that pays for performance over volume. Although there has been significant attention paid to quality measurement within health systems in recent years, significant challenges to meaningful measurement of quality care outcomes remain. Defining cost can be challenging, but is arguably not as elusive as quality, which lacks standard measurement methods and units. To identify industry standards and recommendations for the future, NCCN recently hosted the NCCN Oncology Policy Summit: Defining, Measuring, and Applying Quality in an Evolving Health Policy Landscape and the Implications for Cancer Care. Key stakeholders including physicians, payers, policymakers, patient advocates, and technology partners reviewed current quality measurement programs to identify success and challenges, including the Oncology Care Model. Speakers and panelists identified gaps in quality measurement and provided insights and suggestions for further advancing quality measurement in oncology. This article provides insights and recommendations; however, the goal of this program was to highlight key issues and not to obtain consensus.
Covid-19: Many trusts have not done risk assessments for ethnic minority staff, <i>BMJ</i> investigation finds
Authors: Gareth Iacobucci
Journal: BMJ (2020)

Covid-19: Many trusts have not done risk assessments for ethnic minority staff, BMJ investigation finds Some NHS trusts have been slow to act on calls to assess the increased risks associated with covid-19. Gareth Iacobucci finds out why Gareth IacobucciSome NHS trusts in England are yet to complete covid-19 risk assessments for their staff from ethnic minority groups more than two months after the NHS first told them to do so, an investigation by The BMJ has found.On 29 April NHS England's chief executive, Simon Stevens, wrote to all NHS leaders telling them to carry out risk assessments and make "appropriate arrangements" to protect ethnic minority staff, 1 amid growing evidence that they were at greater risk of contracting and dying from covid-19.This was followed by a mandate to all hospitals on 24 June to complete risk assessments within a month, 2 after a review by Public Health England had reiterated the need to risk assess ethnic minority staff. 3 Data show that almost two thirds of UK healthcare workers who have died from covid-19 were from ethnic minority groups, despite only a fifth of the NHS workforce being from such backgrounds.
P-90 Does the postoperative course of events influence 2-year mortality in patients undergoing hyperthermic intraperitoneal chemotherapy? An evaluation by a novel scoring system
Authors: M. Tatakuri, H. Murthy, J. Ramegowda, R. Karnate, S. Somasekhar, R. Kumar C, S. Zaveri
Journal: Annals of Oncology (2020)
Epidemiology and outcome of acute lung injury in European intensive care units
Authors: Christian Brun-Buisson, Cosetta Minelli, Guido Bertolini, Luca Brazzi, Jorge Pimentel, Klaus Lewandowski, Julian Bion, Jacques-Andr� Romand, Jes�s Villar, Adalbj�rn Thorsteinsson, Pierre Damas, Apostolos Armaganidis, Fran�ois Lemaire
Journal: Intensive Care Medicine (2004)
P-255 Effects of tumor treating fields (150 kHz) in combination with FOLFOX on gastric cancer cells in vitro
Authors: E. Zeevi, K. Gotlib, R. Schneiderman, M. Munster, Y. Porat, T. Voloshin, S. Davidi, A. Shteingauz, N. Kaynan, M. Giladi, U. Weinberg, Y. Palti
Journal: Annals of Oncology (2020)
P-364 Higher amount of KRAS mutations in pre-operative plasma cell-free DNA predicts shorter survival after liver metastasectomy in colorectal cancer patients
Authors: J. Polivka, J. Windrichova, K. Houfkova, H. Rezackova, T. Macanova, M. Karlikova, O. Vycital, R. Kucera, O. Topolcan, D. Slouka, M. Pesta
Journal: Annals of Oncology (2020)
P-27 Retrospective observational analysis of p53 mutational status as a prognostic factor in TAS-102 treated metastatic colorectal cancer patients
Authors: R. Giampieri, A. Zizzi, A. Bittoni, F. Pecci, E. Giglio, M. Giulia, A. Lupi, A. Mandolesi, C. Copparoni, S. Crocetti, F. Bini, A. Lanese, E. Lenci, L. Cantini, M. Baleani, T. Meletani, R. Berardi
Journal: Annals of Oncology (2020)
ヒト冠状微小動脈におけるアンジオテンシンII-アルドステロン相互作用にはGPR30,EGFR,および内皮一酸化窒素シンターゼが関与する
Authors: W Batenburg Wendy, M Jansen Pieter, J Van Den Bogaerdt Antoon, H J Danser Alexander
Journal: Cardiovascular Research (2012)
Risk factors for myocardial injury and death in patients with COVID-19: insights from a cohort study with chest computed tomography
Authors: Giuseppe Ferrante, Fabio Fazzari, Ottavia Cozzi, Matteo Maurina, Renato Bragato, Federico D’Orazio, Chiara Torrisi, Ezio Lanza, Eleonora Indolfi, Valeria Donghi, Riccardo Mantovani, Gaetano Liccardo, Antonio Voza, Elena Azzolini, Luca Balzarini, Bernhard Reimers, Giulio G Stefanini, Gianluigi Condorelli, Lorenzo Monti
Journal: Cardiovascular Research (2020)

Whether pulmonary artery (PA) dimension and coronary artery calcium (CAC) score, as assessed by chest computed tomography (CT), are associated with myocardial injury in patients with coronavirus disease 2019 (COVID-19) is not known. The aim of this study was to explore the risk factors for myocardial injury and death and to investigate whether myocardial injury has an independent association with all-cause mortality in patients with COVID-19.
P-257 Deep polychromatic flow cytometry characterization of circulating endothelial cells in metastatic colorectal cancer patients
Authors: D. Brocco, D. Pietro, P. Lanuti, P. Simeone, G. Bologna, M. Martino, M. De Tursi, N. Tinari, M. Marchisio, S. Miscia, A. Cama
Journal: Annals of Oncology (2020)
Two-year cost effectiveness between two gradual tapering strategies in rheumatoid arthritis: cost-utility analysis of the TARA trial
Authors: Elise van Mulligen, Angelique E Weel, Tjallingius Martijn Kuijper, N H A M Denissen, Andreas H Gerards, Mike H de Jager, Wai-Kwan Lam-Tse, J M Hazes, Annette van der Helm-van Mil, Pascal Hendrik Pieter de Jong, Jolanda J Luime
Journal: Annals of the Rheumatic Diseases (2020)

Objective The aim of the current study was to evaluate the 2-year cost-utility ratio between tapering conventional synthetic disease-modifying antirheumatic drugs (csDMARD) first followed by the tumour necrosis factor (TNF)-inhibitor, or vice versa, in patients with rheumatoid arthritis (RA). Methods Two-year data of the Tapering strategies in Rheumatoid Arthritis trial were used. Patients with RA, who used both a csDMARD and a TNF-inhibitor and had a well-controlled disease (disease activity score ≤2.4 and swollen joint count≤1) for at least 3 months, were randomised into gradual tapering the csDMARD first followed by the TNF-inhibitor, or vice versa. Quality-adjusted life years (QALYs) were derived from the European Quality of life questionnaire with 5 dimensions. Healthcare and productivity costs were calculated with data from patient records and questionnaires. The incremental cost-effectiveness ratio and the incremental net monetary benefit were used to assess cost effectiveness between both tapering strategies. Results 94 patients started tapering their TNF-inhibitor first, while the other 95 tapered their csDMARD first. QALYs (SD) were, respectively, 1.64 (0.22) and 1.65 (0.22). Medication costs were significantly lower in the patients who tapered the TNF-inhibitor first, while indirect cost were higher due to more productivity loss (p=0.10). Therefore, total costs (SD) were €38 833 (€39 616) for tapering csDMARDs first, and €39 442 (€47 271) for tapering the TNF-inhibitor (p=0.88). For willingness-to-pay (WTP) levels &lt;€83 800 tapering, the csDMARD first has the highest probability of being cost effective, while for WTP levels &gt;€83 800 tapering the TNF-inhibitor first has the highest probability. Conclusion Our economic evaluation shows that costs are similar for both tapering strategies. Regardless of the WTP, tapering either the TNF-inhibitor or the csDMARD first is equally cost effective. Trial registration number NTR2754.
The art of survival
Authors: Sarah Ditum
Journal: The Lancet (2020)

An artist can turn bad luck into good fortune. Texas-born author Katherine Anne Porter caught and nearly died from influenza in the 1918–19 pandemic, but the experience gave her the material for Pale Horse, Pale Rider—the title piece of this selection from Penguin Modern Classics—and not only the finest of her very fine short stories, but also the greatest literary account of the "Spanish" influenza. Very few writers besides Porter addressed the disease, effectively making her the laureate of a tragedy that no one much cared to remember until the parallels with COVID-19 recalled it to collective consciousness.
P-226 Analysis of Hispanic Latino American patients with colorectal cancer, clinical features and laterality as a prognosis factor of overall survival
Authors: G. Calderillo-Ruiz, C. Diaz, D. Heredia, B. Carbajal-López, H. Lopez Basave, V. Itzel, E. Ruiz-Garcia, A. Herrera, A. Meneses-Garcia
Journal: Annals of Oncology (2020)
Covid-19: Experts criticise claim that remdesivir cuts death rates
Authors: Michael Day
Journal: BMJ (2020)

Covid-19: Experts criticise claim that remdesivir cuts death rates Michael DayExperts have criticised pharmaceutical firm Gilead Sciences after it released data suggesting that its antiviral drug remdesivir can reduce death rates for patients with covid-19.They say the research is intrinsically flawed and that the claimed benefits are overhyped and inappropriately promoted in press releases.
P-184 A phase 2 trial of trastuzumab deruxtecan (T-DXd, DS-8201) in patients with HER2-positive, unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma
Authors: C. Fuchs, J. Shahidi, L. Mathew, A. Qin, E. Van Cutsem
Journal: Annals of Oncology (2020)
AGER1 downregulation associates with fibrosis in nonalcoholic steatohepatitis and type 2 diabetes
Authors: Ali Dehnad, Weiguo Fan, Joy X. Jiang, Sarah R. Fish, Yuan Li, Suvarthi Das, Gergely Mozes, Kimberly A. Wong, Kristin A. Olson, Gregory W. Charville, Mohammed Ali, Natalie J. Török
Journal: Journal of Clinical Investigation (2020)

Type 2 diabetes is clinically associated with progressive necroinflammation and fibrosis in nonalcoholic steatohepatitis (NASH). Advanced glycation end-products (AGEs) accumulate during prolonged hyperglycemia, but the mechanistic pathways that lead to accelerated liver fibrosis have not been well defined. In this study, we show that the AGEs clearance receptor AGER1 was downregulated in patients with NASH and diabetes and in our NASH models, whereas the proinflammatory receptor RAGE was induced. These findings were associated with necroinflammatory, fibrogenic, and pro-oxidant activity via the NADPH oxidase 4. Inhibition of AGEs or RAGE deletion in hepatocytes in vivo reversed these effects. We demonstrate that dysregulation of NRF2 by neddylation of cullin 3 was linked to AGER1 downregulation and that induction of NRF2 using an adeno-associated virus-mediated approach in hepatocytes in vivo reversed AGER1 downregulation, lowered the level of AGEs, and improved proinflammatory and fibrogenic responses in mice on a high AGEs diet. In patients with NASH and diabetes or insulin resistance, low AGER1 levels were associated with hepatocyte ballooning degeneration and ductular reaction. Collectively, prolonged exposure to AGEs in the liver promotes an AGER1/RAGE imbalance and consequent redox, inflammatory, and fibrogenic activity in NASH.
Abstract 9573: Advance Care Planning and Prognosis Education in Patients With Heart Failure: Insights from the NCDR PINNACLE Registry
Authors: Casey Cavanagh, Lindsey Rosman, Philip Chui, Karl E Minges, Nihar R Desai, Sarah Goodlin, Savitri Fedson, John A Spertus, Tyler J Gluckman, Yang Song, Alexander Turchin, Gheorghe Doros, Jane J Lee, Matthew M Burg
Journal: Circulation (2019)

Introduction: Advance care planning (ACP) and prognosis education are key components of high-quality, patient-centered care in heart failure (HF) and associated with better patient-reported outcome...
Abstract 11259: A Combination of Malnutrition and Muscle Weakness Deteriorates Clinical Outcomes After Transcatheter Aortic Valve Replacement
Authors: Yasuhiro Uchida, Hideki Ishii, Jun Yonekawa, Akinori Satake, Yuichiro Makino, Wataru Suzuki, Masanari Kurobe, Koji Mizutani, Yoshiaki Mizutani, Hitoshi Ichimiya, Akinori Tamenishi, Junji Watanabe, Masaaki Kanashiro, Tetsuya Amano, Matusbara Tatsuaki, Satoshi Ichimiya, Toyoaki Murohara
Journal: Circulation (2019)

Introduction: Although the clinical outcomes of transcatheter aortic valve replacement (TAVR) have significantly improved, some patients still have a poor prognosis due to their intrinsic clinical ...
P-142 Early gastric cancer: Identification of molecular markers able to distinguish penetrating lesions with different prognosis
Authors: C. Molinari, G. Tedaldi, F. Rebuzzi, P. Morgagni, L. Capelli, S. Ravaioli, M. Tumedei, E. Scarpi, A. Tomezzoli, C. Castelli, M. Ambrosio, A. D'Ignazio, L. Solaini, F. Limarzi, P. Ulivi, L. Saragoni
Journal: Annals of Oncology (2020)
Nck1 is a critical adaptor between proatherogenic blood flow, inflammation, and atherosclerosis
Authors: Mary Wines-Samuelson, Sayantani Chowdhury, Bradford C. Berk
Journal: Journal of Clinical Investigation (2020)

Atherosclerosis is an inflammatory condition of the arteries that has profound incidence and increasing prevalence. Although endothelial cells detect changes in blood flow, how endothelial activation contributes to atherogenic inflammation is not well understood. In this issue of the JCI, Alfaidi et al. used mouse models to explore flow-induced endothelial activation. The authors revealed a role for Nck1 and a specific activator of the innate immune response, the downstream interleukin receptor-associated kinase-1 (IRAK-1) in NF-κB-mediated inflammation and atherosclerosis susceptibility. These results link disturbed blood flow to NF-κB-mediated inflammation, which promotes atherosclerosis, and provide Nck1 as a potential target for the treatment of atherosclerosis.
Covid-19: UK must prepare now for winter peak or risk many more deaths, scientists warn
Authors: Gareth Iacobucci
Journal: BMJ (2020)

The UK must prepare now for a potential second wave of covid-19 this winter or risk seeing double the number of hospital deaths that occurred during the first wave, the Academy of Medical Sciences has warned.

In a report1 it said that the combination of covid-19, a backlog of patients needing NHS assessment and treatment, and the possibility of a flu epidemic posed “a serious risk” to health in the UK.

The academy called for “intense preparation” throughout the rest of July and August to reduce the risk of the NHS being overwhelmed and to save lives this winter.

Central to this should be minimising transmission of covid-19 in the community, and …
P-191 Optimal age to start screening for colorectal cancer in average-risk adults: 50 or 45 years old?
Authors: K. Soufleris, E. Stergiou, P. Kevrekidou, S. Bouzoukas, G. Lazaraki, I. Pilpilidis, P. Xiroy, E. Chatzopoulos, D. Tzilves
Journal: Annals of Oncology (2020)
P-117 Prognostic role of plasmatic exosomal and tissue caveolin-1 in metastatic pancreatic cancer patients
Authors: A. Bittoni, F. Pecci, M. Giulia, C. Pellei, A. Zizzi, A. Mandolesi, F. Piva, A. Murrone, L. Cantini, A. Lanese, E. Giglio, T. Meletani, M. Baleani, S. Crocetti, E. Lenci, C. Copparoni, A. Lupi, R. Giampieri, R. Berardi
Journal: Annals of Oncology (2020)
The undiagnosed disease burden associated with alpha-1 antitrypsin deficiency genotypes
Authors: Tomoko Nakanishi, Vincenzo Forgetta, Tomohiro Handa, Toyohiro Hirai, Vincent Mooser, G. Mark Lathrop, William O.C.M. Cookson, J. Brent Richards
Journal: European Respiratory Journal (2020)

Alpha-1 antitrypsin deficiency (AATD), mainly due to the PI*ZZ genotype in SERPINA1 , is one of the most common inherited diseases. Since it is associated with a high disease burden and partially prevented by smoking cessation, identification of PI*ZZ individuals through genotyping could improve health outcomes. We examined the frequency of the PI*ZZ genotype in individuals with and without diagnosed AATD from UK Biobank, and assessed the associations of the genotypes with clinical outcomes and mortality. A phenome-wide association study (PheWAS) was conducted to reveal disease associations with genotypes. A polygenic risk score (PRS) for forced expiratory volume in 1 s (FEV 1 )/forced vital capacity (FVC) ratio was used to evaluate variable penetrance of PI*ZZ. Among 458 164 European-ancestry participants in UK Biobank, 140 had the PI*ZZ genotype and only nine (6.4%, 95% CI 3.4–11.7%) of them were diagnosed with AATD. Those with PI*ZZ had a substantially higher odds of COPD (OR 8.8, 95% CI 5.8–13.3), asthma (OR 2.0, 95% CI 1.4–3.0), bronchiectasis (OR 7.3, 95%CI 3.2–16.8), pneumonia (OR 2.7, 95% CI 1.5–4.9) and cirrhosis (OR 7.8, 95% CI 2.5–24.6) diagnoses and a higher hazard of mortality (2.4, 95% CI 1.2–4.6), compared to PI*MM (wildtype) (n=398 424). These associations were stronger among smokers. PheWAS demonstrated associations with increased odds of empyema, pneumothorax, cachexia, polycythaemia, aneurysm and pancreatitis. Polygenic risk score and PI*ZZ were independently associated with FEV 1 /FVC &lt;0.7 (OR 1.4 per 1- sd change, 95% CI 1.4–1.5 and OR 4.5, 95% CI 3.0–6.9, respectively). The important underdiagnosis of AATD, whose outcomes are partially preventable through smoking cession, could be improved through genotype-guided diagnosis.
Epidemiologic Analysis of Asteroid Hyalosis and Associations: The Gutenberg Health Study
Authors: Hisham Elbaz, Alexander K. Schuster, Stefan Nickels, Markus Nagler, Katharina I. Ponto, Thomas Münzel, Philipp S. Wild, Manfred E. Beutel, Irene Schmidtmann, Karl J. Lackner, Norbert Pfeiffer, Tunde Peto
Journal: Ophthalmology (2020)
Executive summary of the 2020 KDIGO Diabetes Management in CKD Guideline: evidence-based advances in monitoring and treatment
Authors: Ian H. de Boer, M. Luiza Caramori, Juliana C.N. Chan, Hiddo J.L. Heerspink, Clint Hurst, Kamlesh Khunti, Adrian Liew, Erin D. Michos, Sankar D. Navaneethan, Wasiu A. Olowu, Tami Sadusky, Nikhil Tandon, Katherine R. Tuttle, Christoph Wanner, Katy G. Wilkens, Sophia Zoungas, Lyubov Lytvyn, Jonathan C. Craig, David J. Tunnicliffe, Martin Howell, Marcello Tonelli, Michael Cheung, Amy Earley, Peter Rossing
Journal: Kidney International (2020)

Improving Global Outcomes (KDIGO) Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease represents the first KDIGO guideline on this subject. The guideline comes at a time when advances in diabetes technology and therapeutics offer new options to manage the large population of patients with diabetes and chronic kidney disease (CKD) at high risk of poor health outcomes. An enlarging base of high-quality evidence from randomized clinical trials is available to evaluate important new treatments offering organ protection, such as sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists. The goal of the new guideline is to provide evidence-based recommendations to optimize the clinical care of people with diabetes and CKD by integrating new options with existing management strategies. In addition, the guideline contains practice points to facilitate implementation when insufficient data are available to make well-justified recommendations or when additional guidance may be useful for clinical application. The guideline covers comprehensive care of patients with diabetes and CKD, glycemic monitoring and targets, lifestyle interventions, antihyperglycemic therapies, and self-management and health systems approaches to management of patients with diabetes and CKD.
High-Resolution Time-Resolved Phase-Contrast Synchrotron CT for Mapping Cardiac-Induced Lung Motion
Authors: S. Bayat, L. Fardin, L. Broche, G. Lovric, Anders S. Larsson, A. Bravin
Journal: American Journal of Respiratory and Critical Care Medicine (2018)

High-Resolution Time-Resolved Phase-Contrast Synchrotron CT for Mapping Cardiac-Induced Lung Motion
肺静脈単離A全患者に合わせたアプローチを必要としない時空間電位図分散によりガイドされるAFアブレーション【Powered by NICT】
Authors: Seitz Julien, Bars Clement, Theodore Guillaume, Beurtheret Sylvain, Lellouche Nicolas, Bremondy Michel, Ferracci Ange, Faure Jacques, Penaranda Guillaume, Yamazaki Masatoshi, R Avula Uma Mahesh, Curel Laurence, Siame Sabrina, Berenfeld Omer, Pisapia Andre, Kalifa Jerome
Journal: Journal of the American College of Cardiology (2017)
Lipocalin-2 Exacerbates Lupus Nephritis by Promoting Th1 Cell Differentiation
Authors: Weiwei Chen, Wenchao Li, Zhuoya Zhang, Xiaojun Tang, Shufang Wu, Genhong Yao, Kang Li, Dandan Wang, Yuemei Xu, Ruihai Feng, Xiaoxiao Duan, Xiangshan Fan, Liwei Lu, WanJun Chen, Chaojun Li, Lingyun Sun
Journal: Journal of the American Society of Nephrology (2020)

Lipocalin-2 (LCN2) is an indicator of the severity of lupus nephritis (LN) and plays a pivotal role in immune responses, but it is not known if its effect on LN pathogenesis derives from regulating the immune imbalance of T lymphocyte subsets.The expression of LCN2 in T cells and kidneys was assessed in renal biopsies from patients with LN. We investigated the relationship between LCN2 levels and development of LN and systemic illness by injecting anti-LCN2 antibodies into MRL/lpr mice and analyzing pristane-treated LCN2-/- mice.LCN2 is highly expressed in CD4+ T cells and in renal tissues, and is associated with severe renal damage in patients with LN and in mice with experimental lupus. LCN2 promotes IFN-γ overexpression in CD4+ T cells through the IL-12/STAT4 pathway in an autocrine or paracrine manner. Both neutralization of LCN2 in MRL/lpr mice and genetic depletion of LCN2 in pristane-induced lupus mice greatly ameliorate nephritis. The frequency and number of splenic and renal Th1 cells decrease in proportion to LN disease activity. Conversely, administration of LCN2 exacerbates the disease with significantly higher renal activity scores and increased numbers of Th1 cells.LCN2 plays a crucial role in Th1 cell differentiation, and may present a potential therapeutic target for LN.
Osimertinib Improves Overall Survival in Patients With EGFR-Mutated NSCLC With Leptomeningeal Metastases Regardless of T790M Mutational Status
Authors: Jiyun Lee, Yoon La Choi, Joungho Han, Sehhoon Park, Hyun Ae Jung, Jong-Mu Su, Se-Hoon Lee, Jin Seok Ahn, Keunchil Park, Myung-Ju Ahn
Journal: Journal of Thoracic Oncology (2020)