tbuckley/cabot-search huggingface dataset:
Ethical and Legal Considerations of Patients Audio Recording, Videotaping, and Broadcasting Physician Encounters
Authors: Benjamin D. Ferguson, Peter Angelos
Journal: JAMA Surgery (2020)

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Comment on Kwon et al. The Long-term Effects of Metformin on Patients With Type 2 Diabetic Kidney Disease. Diabetes Care 2020;43:948–955
Authors: Edouard L. Fu, Merel van Diepen
Journal: Diabetes Care (2020)

We read with interest the recent study by Kwon et al. (1) examining the long-term effects of metformin use on mortality and incident end-stage kidney disease among 10,426 patients with type 2 diabetic kidney disease. The authors report that metformin use decreased the risk of all-cause mortality by 35% and end-stage renal disease progression by 33% after applying propensity score matching to adjust for a number of measured confounders.

We are concerned by the possible influence of immortal time bias on the study results. Immortal time arises when patients are classified into treatment groups at baseline based on treatment information that is only available after …
Excess Deaths Associated with COVID-19, by Age and Race and Ethnicity — United States, January 26–October 3, 2020
Authors: Lauren M. Rossen, Amy M. Branum, Farida B. Ahmad, Paul Sutton, Robert N. Anderson
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

As of October 15, 216,025 deaths from coronavirus disease 2019 (COVID-19) have been reported in the United States*; however, this number might underestimate the total impact of the pandemic on mortality. Measures of excess deaths have been used to estimate the impact of public health pandemics or disasters, particularly when there are questions about underascertainment of deaths directly attributable to a given event or cause (1-6).† Excess deaths are defined as the number of persons who have died from all causes, in excess of the expected number of deaths for a given place and time. This report describes trends and demographic patterns in excess deaths during January 26-October 3, 2020. Expected numbers of deaths were estimated using overdispersed Poisson regression models with spline terms to account for seasonal patterns, using provisional mortality data from CDC's National Vital Statistics System (NVSS) (7). Weekly numbers of deaths by age group and race/ethnicity were assessed to examine the difference between the weekly number of deaths occurring in 2020 and the average number occurring in the same week during 2015-2019 and the percentage change in 2020. Overall, an estimated 299,028 excess deaths have occurred in the United States from late January through October 3, 2020, with two thirds of these attributed to COVID-19. The largest percentage increases were seen among adults aged 25-44 years and among Hispanic or Latino (Hispanic) persons. These results provide information about the degree to which COVID-19 deaths might be underascertained and inform efforts to prevent mortality directly or indirectly associated with the COVID-19 pandemic, such as efforts to minimize disruptions to health care.
Extrahepatic manifestations of hepatitis C among United States male veterans
Authors: Hashem B. El-Serag, Howard Hampel, Christine Yeh, Linda Rabeneck
Journal: Hepatology (2002)

Hepatitis C virus (HCV) has been associated with several extrahepatic conditions. To date, most studies assessing these associations involved small numbers of patients and lacked a control group. Using the computerized databases of the Department of Veterans Affairs, we carried out a hospital-based case-control study that examined all cases of HCV-infected patients hospitalized during 1992 to 1999 (n = 34,204) and randomly chosen control subjects without HCV (n = 136,816) matched with cases on the year of admission. The inpatient and outpatient files were searched for several disorders involving the skin (porphyria cutanea tarda [PCT], vitiligo, and lichen planus); renal (membranous glomerulonephritis [GN] and membranoproliferative glomerulonephritis); hematologic (cryoglobulin, Hodgkin’s and non-Hodgkin’s lymphoma [NHL]); endocrine (diabetes, thyroiditis); and rheumatologic (Sjögren’s syndrome). The association between HCV and these disorders was examined in multivariate analyses that controlled for age, gender, ethnicity, and period of military service. Patients in the case group were younger in age (45 vs. 57 years), were more frequently nonwhite (39.6% vs. 26.3%), and were more frequently male (98.1% vs. 97.0%). A significantly greater proportion of HCV-infected patients had PCT, vitiligo, lichen planus, and cryoglobulinemia. There was a greater prevalence of membranoproliferative GN among patients with HCV but not membranous GN. There was no significant difference in the prevalence of thyroiditis, Sjögren’s syndrome, or Hodgkin’s or NHL. However, NHL became significant after age adjustment. Diabetes was more prevalent in controls than cases, but no statistically significant association was found after adjustment for age. In conclusion, we found a significant association between HCV infection and PCT, lichen planus, vitiligo, cryoglobulinemia, membranoproliferative GN, and NHL. Patients presenting with these disorders should be tested for HCV infection. (Hepatology2002;36:1439-1445).
Seroconversion in patients with cancer and oncology health care workers infected by SARS-CoV-2
Authors: A. Marra, D. Generali, P. Zagami, V. Cervoni, S. Gandini, S. Venturini, S. Morganti, R. Passerini, R. Orecchia, G. Curigliano
Journal: Annals of Oncology (2020)
TCT CONNECT-490 Health Status Improvements Following Transcatheter Tricuspid Repair With the PASCAL Device in the CLASP TR Early Feasibility Study
Authors: Matthew Reynolds, Yang Song, Ahmad Al-Ghusain, Sarah Mollenkopf, Ted Feldman, Charles Davidson, Mackram Eleid, Robert Kipperman, Robert Smith, Scott Lim, Firas Zahr, William Gray, Adam Greenbaum, Martin Leon, Susheel Kodali
Journal: Journal of the American College of Cardiology (2020)
TCT CONNECT-48 Cooling as an Adjunctive Therapy to Percutaneous Intervention in Acute Myocardial Infarction: COOL-MI InCor Trial
Authors: Luis Augusto Dallan, Natali Giannetti, Carlos Eduardo Rochitte, Thatiane Polastri, Claudia Bernoche, Ludhmila Abrahao Hajjar, Felipe Lima, Jose Carlos Nicolau, Mucio Tavares, Michael Dae, Expedito Ribeiro, Roberto Kalil, Pedro A. Lemos, Sergio Timerman
Journal: Journal of the American College of Cardiology (2020)
Effects of intensive versus standard blood pressure control on domain-specific cognitive function: a substudy of the SPRINT randomised controlled trial
Authors: Stephen R Rapp, Sarah A Gaussoin, Bonnie C Sachs, Gordon Chelune, Mark A Supiano, Alan J Lerner, Virginia G Wadley, Valarie M Wilson, Lawrence J Fine, Jeff C Whittle, Alexander P Auchus, Srinivasan Beddhu, Dan R Berlowitz, Adam P Bress, Karen C Johnson, Marie Krousel-Wood, Jennifer Martindale-Adams, Eliza C Miller, Dena E Rifkin, Joni K Snyder, Leonardo Tamariz, Dawn F Wolfgram, Maryjo L Cleveland, Mia Yang, Linda O Nichols, Robert Nick Bryan, David M Reboussin, Jeff D Williamson, Nicholas M Pajewski, Stephen R Rapp, Nicholas M Pajewski, Alexander P Auchus, Gordon Chelune, Alfred K Cheung, Maryjo L Cleveland, Laura H Coker, Michael G Crowe, William C Cushman, Jeffery A Cutler, Christos Davatzikos, Lisa Desiderio, Jimit Doshi, Guray Erus, Lawrence J Fine, Sarah A Gaussoin, Darrin Harris, Karen C Johnson, Paul L Kimmel, Manjula K Tamura, Lenore J Launer, Alan J Lerner, Cora E Lewis, Jennifer Martindale-Adams, Claudia S Moy, Linda O Nichols, Suzanne Oparil, Paula K Ogrocki, Mahboob Rahman, Ilya M Nasrallah, David M Reboussin, Michael V Rocco, Bonnie C Sachs, Kaycee M Sink, Carolyn H Still, Mark A Supiano, Joni K Snyder, Virginia G Wadley, Jennifer Walker, Daniel E Weiner, Paul K Whelton, Valerie M Wilson, Nancy Woolard, Jackson T Wright, Clinton B Wright, Jeff D Williamson, R Nick Bryan
Journal: The Lancet Neurology (2020)
3D additive manufactured composite scaffolds with antibiotic-loaded lamellar fillers for bone infection prevention and tissue regeneration
Authors: María Cámara-Torres, Stacy Duarte, Ravi Sinha, Ainhoa Egizabal, Noelia Álvarez, Maria Bastianini, Michele Sisani, Paolo Scopece, Marco Scatto, Alessandro Bonetto, Antonio Marcomini, Alberto Sanchez, Alessandro Patelli, Carlos Mota, Lorenzo Moroni
Journal: Bioactive Materials (2020)

Bone infections following open bone fracture or implant surgery remain a challenge in the orthopedics field. In order to avoid high doses of systemic drug administration, optimized local antibiotic release from scaffolds is required. 3D additive manufactured (AM) scaffolds made with biodegradable polymers are ideal to support bone healing in non-union scenarios and can be given antimicrobial properties by the incorporation of antibiotics. In this study, ciprofloxacin and gentamicin intercalated in the interlamellar spaces of magnesium aluminum layered double hydroxides (MgAl) and α-zirconium phosphates (ZrP), respectively, are dispersed within a thermoplastic polymer by melt compounding and subsequently processed via high temperature melt extrusion AM (~190 °C) into 3D scaffolds. The inorganic fillers enable a sustained antibiotics release through the polymer matrix, controlled by antibiotics counterions exchange or pH conditions. Importantly, both antibiotics retain their functionality after the manufacturing process at high temperatures, as verified by their activity against both Gram + and Gram - bacterial strains. Moreover, scaffolds loaded with filler-antibiotic do not impair human mesenchymal stromal cells osteogenic differentiation, allowing matrix mineralization and the expression of relevant osteogenic markers. Overall, these results suggest the possibility of fabricating dual functionality 3D scaffolds via high temperature melt extrusion for bone regeneration and infection prevention.
TCT CONNECT-131 Outcomes in Transcatheter Aortic Valve Replacement in Patients With Anemia Requiring Red Blood Cell Transfusion: A Nationwide Prospective
Authors: Ali Ghani, Sundeep Kumar, Ziad SayedAhmad, Hiren Patel, Akhil Mogalapalli, Soumya Banna, Nishita Kumar, Zachary Oman, Ammar Nasir, Philip Mar
Journal: Journal of the American College of Cardiology (2020)
Bone Scintigraphy in Pembrolizumab-Induced Inflammatory Arthritis
Authors: Masamichi Imai, Yuki Kosaka, Masato Tachi, Kazuaki Mori, Hirotaka Maruno
Journal: Clinical Nuclear Medicine (2020)

Abstract We present a novel report on the use of bone scintigraphy in pembrolizumab-induced inflammatory arthritis. A 70-year-old man with lung cancer complained about arthralgia after 7 courses of the pembrolizumab therapy. 99m Tc-HMDP bone scintigraphy revealed symmetrically strong uptakes in the major distal joints of the upper and lower extremities, thereby clearly identifying them as the affected joints. The pattern of uptakes was not consistent with that of other pathophysiologies including bone metastases, hypertrophic osteoarthropathy, and rheumatoid arthritis. 99m Tc-HMDP bone scintigraphy is more practical and cost-effective compared with PET to reveal the affected joints in pembrolizumab-induced inflammatory arthritis.
Hematopoietic Stem Cell Transplantation for Autoimmune Disease
Authors: Tobias Alexander, Raffaella Greco, John A. Snowden
Journal: Annual Review of Medicine (2020)

The introduction of targeted biologic therapies has changed the treatment landscape for autoimmune diseases (ADs) substantially, but although these therapies provide more specificity, they require continuous administration, rarely restore organ function or reverse disability, and are not curative. Over the last 25 years, hematopoietic stem cell transplantation (HSCT) has been increasingly used to treat patients in whom the risk:benefit ratio of HSCT is acceptable. In contrast to chronic suppression of immune function, this intensive one-off procedure aims to provide treatment-free remissions by the reinduction of self-tolerance. The European Society for Blood and Marrow Transplantation (EBMT) Autoimmune Diseases Working Party (ADWP) has been central to development of this approach, with over 3,300 HSCT registrations for ADs. Recent data have improved the evidence base to support autologous HSCT in multiple sclerosis, systemic sclerosis, and Crohn's disease, along with a wide range of rarer disease indications, and autologous HSCT has become an integral part of treatment algorithms in various ADs.
Chemotherapy-free Treatment — A New Era in Acute Lymphoblastic Leukemia?
Authors: Dieter Hoelzer
Journal: New England Journal of Medicine (2020)

In this issue of the Journal, Foà et al.1 report on an innovative approach to treat acute lymphoblastic leukemia (ALL) involving the replacement of chemotherapy with targeted therapies, including dexamethasone, the tyrosine kinase inhibitor dasatinib, and the bispecific anti-CD3 and anti-CD19 antibody blinatumomab. This new regimen is feasible, active, and safe, with very low treatment-related mortality and promising overall and disease-free survival outcomes. This is a change in the treatment approach. The use of intensive multiagent chemotherapy in children with ALL has led to a long-term cure in more than 90% of patients. However, the treatment that has led to . . .
ATP-supplies in the cold-preserved liver: A long-neglected factor of organ viability
Authors: Katarína Vajdová, Rolf Graf, Pierre-Alain Clavien
Journal: Hepatology (2002)

he goal of liver preservation during transplant surgery is to maintain cellular viability, to allow T early resumption of normal cellular metabolism on reperfusion, and thus to avoid the potential morbidity and mortality associated with poor graft function.The major tool used for liver preservation today is cold organ storage, which reduces metabolic activity by lowering the temperature to between 1 to 4°C.'To accomplish organ protection during prolonged cold ischemia different cold-storage solutions were designed.Belzer's and Southard's University of Wisconsin (UW) solution has been successfully used worldwide since the first clinical use in 1987.This complex solution supports good graft function even after extended cold preservation.2The preservation principles of the U W solution are based on the prevention of liver-specific cellular features occurring during cold ischemia.Intracellular edema is prevented by adding nonmetabolizable impermeants such as lactobionate and raffinose.The colloid, hydroxyethyl starch, suppresses expansion of extracellular space.The solution contains no glucose to avoid intracellular acidosis and it contains the hydrogen ion buffer KH2P04.Glutathione and allopurinol are added to prevent injury by oxygen radicals.Allopurinol, a xanthine oxidase inhibitor, can also salvage adenosine triphosphate (ATP) precursors.The purine nucleotide pool for ATP synthesis is further supported by adding adenosine.'Another solution, Bretschneider's histidine-tryptophan-ketoglutarate (HTK), was designed for cardiac preservation and it was formulated to retard acidosis
Discovery of biomarker candidates associated with the risk of short-term and mid/long-term relapse after infliximab withdrawal in Crohn’s patients: a proteomics-based study
Authors: Nicolas Pierre, Dominique Baiwir, Vân Anh Huynh-Thu, Gabriel Mazzucchelli, Nicolas Smargiasso, Edwin De Pauw, Yoram Bouhnik, David Laharie, Jean-Frédéric Colombel, Marie-Alice Meuwis, Edouard Louis
Journal: Gut (2020)

A subset of Crohn's disease (CD) patients experiences mid/long-term remission after infliximab withdrawal. Biomarkers are needed to identify those patients.
<i>Nfkb2</i> variants reveal a p100-degradation threshold that defines autoimmune susceptibility
Authors: Rushika C. Wirasinha, Ainsley R. Davies, Monika Srivastava, Julie M. Sheridan, Xavier Y.X. Sng, Ottavia M. Delmonte, Kerry Dobbs, Khai L. Loh, Lisa A. Miosge, Cindy Eunhee Lee, Rochna Chand, Anna Chan, Jin Yan Yap, Michael D. Keller, Karin Chen, Jamie Rossjohn, Nicole L. La Gruta, Carola G. Vinuesa, Hugh H. Reid, Michail S. Lionakis, Luigi D. Notarangelo, Daniel H.D. Gray, Christopher C. Goodnow, Matthew C. Cook, Stephen R. Daley
Journal: The Journal of Experimental Medicine (2020)

NF-κB2/p100 (p100) is an inhibitor of κB (IκB) protein that is partially degraded to produce the NF-κB2/p52 (p52) transcription factor. Heterozygous NFKB2 mutations cause a human syndrome of immunodeficiency and autoimmunity, but whether autoimmunity arises from insufficiency of p52 or IκB function of mutated p100 is unclear. Here, we studied mice bearing mutations in the p100 degron, a domain that harbors most of the clinically recognized mutations and is required for signal-dependent p100 degradation. Distinct mutations caused graded increases in p100-degradation resistance. Severe p100-degradation resistance, due to inheritance of one highly degradation-resistant allele or two subclinical alleles, caused thymic medullary hypoplasia and autoimmune disease, whereas the absence of p100 and p52 did not. We inferred a similar mechanism occurs in humans, as the T cell receptor repertoires of affected humans and mice contained a hydrophobic signature of increased self-reactivity. Autoimmunity in autosomal dominant NFKB2 syndrome arises largely from defects in nonhematopoietic cells caused by the IκB function of degradation-resistant p100.
TCT CONNECT-25 Primary Coronary Intervention Using a Single Universal Guiding Catheter to Shorten Door-to-Balloon Time in ST-Segment Elevation Myocardial Infarction: An Analysis of a Multicenter Registry
Authors: Kyong Hee Lee, Sho Torii, Mitsutoshi Oguri, Akihiko Takahashi, Yujiro Ono, Kaoru Iwabuchi, Tsuyosi Miyaji, Takahiko Kiyooka, Taichi Adachi, Kouhei Asada, Shuji Otsuki, Masakazu Tanaka, Masaru Yamaki, Kouhei Moribayashi, Shiro Uemura, Ryuji Tsuburaya, Kohei Ueda, Takeshi Ijichi, Motohiko Kakuno, Shukou Iwata, Yuji Ikari
Journal: Journal of the American College of Cardiology (2020)
Mir-30d Regulates Cardiac Remodeling by Intracellular and Paracrine Signaling
Authors: Jin Li, Ane M. Salvador, Guoping Li, Nedyalka Valkov, Olivia Ziegler, Ashish Yeri, Chun Yang Xiao, Bessie Meechoovet, Eric Alsop, Rodosthenis S. Rodosthenous, Piyusha Kundu, Tianxiao Huan, Daniel Levy, John Tigges, Alexander R. Pico, Ionita Ghiran, Michael G. Silverman, Xiangmin Meng, Robert Kitchen, Jiahong Xu, Kendall Van Keuren-Jensen, Ravi Shah, Junjie Xiao, Saumya Das
Journal: Circulation Research (2020)

Previous translational studies implicate plasma extracellular microRNA-30d (miR-30d) as a biomarker in left ventricular remodeling and clinical outcome in heart failure (HF) patients, although precise mechanisms remain obscure.
TCT CONNECT-35 Long-Term Outcome Following Primary Percutaneous Coronary Intervention Among Elderly (&lt;80) Versus Very Elderly (≥80) Patients With ST-Segment Elevation Myocardial Infarction: A 6-Year Analysis From a Single-Center Study in the United Kingdom
Authors: Siddhartha Mengi, Gareth Lau, Matthew Saint, Sen Devadathan, Harmandeep Tinna
Journal: Journal of the American College of Cardiology (2020)
A MYC and RAS co-activation signature in localized prostate cancer drives bone metastasis and castration resistance
Authors: Juan M. Arriaga, Sukanya Panja, Mohammed Alshalalfa, Junfei Zhao, Min Zou, Arianna Giacobbe, Chioma J. Madubata, Jaime Yeji Kim, Antonio Rodriguez, Ilsa Coleman, Renu K. Virk, Hanina Hibshoosh, Onur Ertunc, Büşra Ozbek, Julia Fountain, R. Jeffrey Karnes, Jun Luo, Emmanuel S. Antonarakis, Peter S. Nelson, Felix Y. Feng, Mark A. Rubin, Angelo M. De Marzo, Raul Rabadan, Peter A. Sims, Antonina Mitrofanova, Cory Abate-Shen
Journal: Nature Cancer (2020)
TCT CONNECT-306 Does the Lack of Right Coronary Artery Support Affect Prognosis in Patients Undergoing Percutaneous Coronary Intervention for Unprotected Left Main Coronary Artery Disease?
Authors: Wojciech Skorupski, Marek Grygier, Przemyslaw Mitkowski, Malgorzata Pyda, Wlodzimierz Skorupski, Stefan Grajek, Aleksander Araszkiewicz, Andrzej Siniawski, Michał Lesiak, Stanislaw Jankiewicz, Sylwia Iwanczyk, Maciej Lesiak, Marta Kaluzna-Oleksy
Journal: Journal of the American College of Cardiology (2020)
Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress‐ and aging‐related diseases
Authors: Alexander G. Panossian, Thomas Efferth, Alexander N. Shikov, Olga N. Pozharitskaya, Kenny Kuchta, Pulok K. Mukherjee, Subhadip Banerjee, Michael Heinrich, Wanying Wu, De‐an Guo, Hildebert Wagner
Journal: Medicinal Research Reviews (2020)

Abstract Adaptogens comprise a category of herbal medicinal and nutritional products promoting adaptability, resilience, and survival of living organisms in stress. The aim of this review was to summarize the growing knowledge about common adaptogenic plants used in various traditional medical systems (TMS) and conventional medicine and to provide a modern rationale for their use in the treatment of stress‐induced and aging‐related disorders. Adaptogens have pharmacologically pleiotropic effects on the neuroendocrine‐immune system, which explain their traditional use for the treatment of a wide range of conditions. They exhibit a biphasic dose‐effect response: at low doses they function as mild stress‐mimetics, which activate the adaptive stress‐response signaling pathways to cope with severe stress. That is in line with their traditional use for preventing premature aging and to maintain good health and vitality. However, the potential of adaptogens remains poorly explored. Treatment of stress and aging‐related diseases require novel approaches. Some combinations of adaptogenic plants provide unique effects due to their synergistic interactions in organisms not obtainable by any ingredient independently. Further progress in this field needs to focus on discovering new combinations of adaptogens based on traditional medical concepts. Robust and rigorous approaches including network pharmacology and systems pharmacology could help in analyzing potential synergistic effects and, more broadly, future uses of adaptogens. In conclusion, the evolution of the adaptogenic concept has led back to basics of TMS and a new level of understanding of holistic approach. It provides a rationale for their use in stress‐induced and aging‐related diseases.
TCT CONNECT-481 Histopathological Analysis of Embolized Debris From Bioprosthetic Valve Fracture: An Ex-Vivo Bench Study
Authors: Subhashaan Sreedharan, Janarthanan Sathananthan, Tim Cartlidge, Althea Lai, Hannah Salcudean, Abdul Rahman Ihdayhid, Mark Hensey, Philipp Blanke, David Wood, Marc Dweck, David Newby, Bruce McManus, Chi Lai, John Webb, Jonathon Leipsic, Stephanie Sellers
Journal: Journal of the American College of Cardiology (2020)