tbuckley/cabot-search huggingface dataset:
Rabbit Anti-Thymocyte Globulin Exposure (rATG) in CD34+ Selected Hematopoietic Cell Transplantation and Its Impact on Immune Reconstitution and Outcomes in Children and Adults
Authors: Madhavi Lakkaraja, Michael Scordo, Audrey Mauguen, Christina Cho, Sean Devlin, Scott T Avecilla, Farid Boulad, Maria I. Cancio, Kevin J. Curran, Ann A. Jakubowski, Nancy A. Kernan, Andrew L. Kung, Richard J O'Reilly, Esperanza B. Papadopoulos, Susan Prockop, Ichelle Roessel, Josel D Ruiz, Andromachi Scaradavou, Brian C. Shaffer, Gunjan Shah, Barbara Spitzer, Roni Tamari, Sergio A. Giralt, Miguel-Angel Perales, Jaap Jan Boelens
Journal: Blood (2020)
Decisional Involvement, Information Preferences, and Prognostic Optimism Among Patients with Hematologic Malignancies
Authors: Kah Poh Loh, Mazie Tsang, Thomas W. Leblanc, Anthony Back, Paul Duberstein, Supriya G. Mohile, Ronald Epstein, Heidi D. Klepin, Michael W. Becker, Areej El-Jawahri, Stephanie J. Lee
Journal: Blood (2020)
Noninvasive and minimally invasive techniques for the diagnosis and management of allergic diseases
Authors: Ralf Baumann, Eva Untersmayr, Ulrich M. Zissler, Stefanie Eyerich, Ian M. Adcock, Knut Brockow, Tilo Biedermann, Markus Ollert, Adam M. Chaker, Oliver Pfaar, Holger Garn, Ryan S. Thwaites, Alkis Togias, Marek L. Kowalski, Trevor T. Hansel, Constanze A. Jakwerth, Carsten B. Schmidt‐Weber
Journal: Allergy (2020)

Abstract Allergic diseases of the (upper and lower) airways, the skin and the gastrointestinal tract, are on the rise, resulting in impaired quality of life, decreased productivity, and increased healthcare costs. As allergic diseases are mostly tissue‐specific, local sampling methods for respective biomarkers offer the potential for increased sensitivity and specificity. Additionally, local sampling using noninvasive or minimally invasive methods can be cost‐effective and well tolerated, which may even be suitable for primary or home care sampling. Non‐ or minimally invasive local sampling and diagnostics may enable a more thorough endotyping, may help to avoid under‐ or overdiagnosis, and may provide the possibility to approach precision prevention, due to early diagnosis of these local diseases even before they get systemically manifested and detectable. At the same time, dried blood samples may help to facilitate minimal‐invasive primary or home care sampling for classical systemic diagnostic approaches. This EAACI position paper contains a thorough review of the various technologies in allergy diagnosis available on the market, which analytes or biomarkers are employed, and which samples or matrices can be used. Based on this assessment, EAACI position is to drive these developments to efficiently identify allergy and possibly later also viral epidemics and take advantage of comprehensive knowledge to initiate preventions and treatments.
Enasidenib, an Oral Therapy in Mutant IDH2 Relapsed/Refractory Acute Myeloid Leukemia: A Real-Life Single Center Experience
Authors: Marta Riva, Lorenzo Rizzo, Valentina Mancini, Rosa Greco, Giambattista Bertani, Elisa Zucchetti, Elisa Diral, Michele Nichelatti, Silvio Marco Veronese, Giovanni Grillo, Roberto Cairoli
Journal: Blood (2020)
Richard Turner-Warwick: the “father of reconstructive urology”
Authors: John Illman
Journal: BMJ (2020)

Credit: BJU International

Richard Turner-Warwick (RTW, as he was widely known) was renowned for designing and making surgical instruments in his own workshop and flying the world to demonstrate them. In the 1950s and 1960s, before universal audiovisual electronic communication, the only way to show off his innovative wares was to demonstrate them in the operating theatre. This became possible thanks to visiting professorships—more than 200 in the US and Australasia alone.

Many of the instruments he invented and adapted remain in surgical trays today. His apprenticeship began when he was still in short trousers. Inspired by his mother, a doctor and able mechanic; and his grandfather, a dentist who was a woodworker and silversmith in his spare time, RTW was intrigued about how things were made and worked. His mother taught him how to dismantle a car engine down to the big ends and to reassemble it—before his 10th birthday. He spent many happy hours making things with his grandfather in …
Minimal Residual Disease Monitoring from Liquid Biopsy By Next Generation Sequencing in Follicular Lymphoma Patients
Authors: Ana Isabel Jiminez Ubieto, Yanira Heredia, Juan Manuel de la Rosa, Antonia Rodriguez Izquierdo, Laura Rufian, Jaime Carrillo, Ricardo Sanchez, Esther Onecha, Chongwu Wang, Pilar Sarandeses, María Poza, Carmen Bárcena, Carlos Grande, Miguel A Canales, Inmaculada Rapado, Rosa Ayala, Miguel Gallardo, Joaquin Martinez-López, Santiago Barrio
Journal: Blood (2020)
Abstract 499: Modeling Carfilzomib Induced Cardiotoxicity Using Human Induced Pluripotent Stem Cell-derived Cardiomyocytes
Authors: Parvin Forghani, Aysha Rashid, Dong Li, Anant Mandawat, Chunhui XU
Journal: Circulation Research (2020)

Cardiovascular toxicity post Carfilzomib (Cfz/Kyprolis) therapy has been identified in several clinical settings. A prevalent challenge in side effects of anti-cancer drugs is the translation of findings from preclinical research into clinical practice. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are being used as a physiological in vitro model to overcome some of these challenges. Here we used both 2D and 3D hiPSC-CMs to elucidate the underlying mechanism of post-Cfz cardiotoxicity. hiPSC-CMs were exposed to clinically relevant doses of Cfz based on C max for Cfz (5.88 μM). Data normalization against the control group demonstrates significant reduction in cell viability following two days of treatment with Cfz in 3 different cell lines (IMR-90, SCVI273 and 902). Increased Caspase3/7 activity post Cfz treatment paralleled with a substantial decrease in mitochondrial membrane potential and increase in oxidative stress following Cfz treatment. Also, significant decrease in oxygen consumption rate was observed after one-day exposure. In addition, we observed impaired Ca 2+ handling at the single cell level following Cfz treatment. Using video microscopy with motion vector analysis we also observed significant decrease in contractility of 3D hiPSC-CMs following Cfz treatment. Additionally, we observed disrupted expression of α-actinin, alterations in structural organization of sarcomeres, circularity and aspect ratio. Altogether, these results suggest that Cfz induced cardiotoxicity as indicated by cell viability, oxidative stress, mitochondrial and structural damages along with abnormal Ca 2+ handing and contractility dysfunction.
Viral Immunity and Vaccines in Hematologic Malignancies: Implications for COVID-19
Authors: Madhav V. Dhodapkar, Kavita M. Dhodapkar, Rafi Ahmed
Journal: Blood Cancer Discovery (2020)

Abstract Summary: Patients with hematologic malignancies have increased susceptibility to viral infections and suboptimal immunologic responses to current vaccines due to both disease-associated and therapy-related immune dysfunction. These considerations may impact the efficacy of emerging COVID-19 vaccines in this patient population as well and warrant the need to systematically study natural and vaccine-induced virus-specific immunity in these patients.
Efficacy and Safety of Ponatinib (PON) in Patients with Chronic-Phase Chronic Myeloid Leukemia (CP-CML) Who Failed One or More Second-Generation (2G) Tyrosine Kinase Inhibitors (TKIs): Analyses Based on PACE and Optic
Authors: Hagop M. Kantarjian, Michael W. Deininger, Elisabetta Abruzzese, Jane Apperley, Jorge E. Cortes, Charles Chuah, Daniel J. DeAngelo, John F. DiPersio, Andreas Hochhaus, Jeffrey H. Lipton, Franck E Nicolini, Javier Pinilla Ibarz, Delphine Rea, Gianantonio Rosti, Philippe Rousselot, Neil P Shah, Moshe Talpaz, Shouryadeep Srivastava, Vickie Lu, Michael J. Mauro
Journal: Blood (2020)
THU0623-HPR REVISION AND VALIDATION OF THE GERMAN VERSION OF THE SYSTEMIC SCLEROSIS QUALITY OF LIFE QUESTIONNAIRE (SSCQOL) WITH MOKKEN SCALE ANALYSIS
Authors: A. Kocher, M. Ndosi, K. Hoeper, M. Simon, D. Nicca
Journal: Annals of the Rheumatic Diseases (2020)

Background: The Systemic Sclerosis Quality of Life Questionnaire (SScQoL) has been validated in six European languages. 1 Previous adaptation into German revealed issues with the dichotomous response structure in 10 items necessitating a review of the tool and further psychometric testing with patients in German speaking countries. Objectives: The aim of this study was to assess the German version of the SScQoL, extend the response structure and test its construct validity using Mokken scale analysis. Methods: This was a mixed methods study involving cognitive debriefing and survey methods. The expert committee extended the response structure of the 10 items from dichotomous to polytomous (4-point) responses: ‘always’, ‘usually’, ‘sometimes’ and ‘never’. In cognitive debriefing, a small convenience sample of patients with SSc completed the new version while ‘thinking aloud’ and commented on relevance of the items and the response structure. Results: In cognitive debriefing, six patients with SSc completed the new German SScQoL and reported problems with the remaining dichotomous items. These were subsequently converted into polytomous 4-point response structure by the expert committee. Conclusion: The German SScQoL has been revised into polytomous item structure and shown to be a valid and reliable measure of health-related quality of life in SSc. Further cross-cultural validity tests are required to assess its measurement equivalence with other SScQoL versions and thus enable multinational comparisons. References: [1]Ndosi M, Alcacer-Pitarch B, Allanore Y et al. Common measure of quality of life for people with systemic sclerosis across seven European countries: a cross-sectional study . Ann Rheum Dis , 2018; 77: 1032-1038 Table 1. Mokken scale analysis of the revised German SScQoL Subscale (items) Scalability ( H ) Standard error Function (6) 0.664 0.048 Emotional (13) 0.652 0.060 Sleep (2) 0.798 0.061 Social (6) 0.692 0.053 Pain (2) 0.960 0.029 Global scale (29) 0.623 0.062 Table legend: scalability H ≥ 0.50 = strong, 0.49 to 0.40 = moderate, 0.39 to 0.30 = weak, while values of &lt; 0.30 are not considered as unidimensional. Disclosure of Interests: Agnes Kocher Grant/research support from: Sandoz to support the development of an eLearning module for patients with rheumatic diseases., Mwidimi Ndosi Grant/research support from: Bristol Myers Squibb, Consultant of: Janssen, Pfizer, Kirsten Hoeper Consultant of: AbbVie, Celgene,, Speakers bureau: Abbvie, Chugai, Novartis, Lilly, Celgene, Sandoz Hexal, Michael Simon: None declared, Dunja Nicca: None declared
Macrophage Activation By Dual PI3K-δ/γ Inhibition Enhances Anti-CD47-Mediated Phagocytosis and Prolongs Survival in DLBCL
Authors: James Godfrey, Wenjun Kang, Lei Huang, Silvia Coma, Roy Maute, Mark P. Chao, Jonathan A Pachter, Sonali Smith, Justin Kline
Journal: Blood (2020)
Axl-RTK Inhibition Modulates Monocyte Immune Response to Enhance the Anti-Tumor Effects of CD19 Redirected Chimeric Antigen Receptor T Cells in Preclinical Models
Authors: Reona Sakemura, Michelle J. Cox, Elizabeth L. Siegler, Erin E. Tapper, Wendy K. Nevala, Mehrdad Hefazi, Claudia Manriquez Roman, Kendall J. Schick, Ismail Can, Evandro D. Bezerra, Lionel Kankeu Fonkoua, Paulina Horvei, Michael W. Ruff, Lars Mouritsen, Jason M. Foulks, Steven L. Warner, Wei Ding, Susan L. Slager, Sameer A. Parikh, Neil E. Kay, Saad S. Kenderian
Journal: Blood (2020)
The clinical significance of duration of untreated psychosis: an umbrella review and random‐effects meta‐analysis
Authors: Oliver D. Howes, Thomas Whitehurst, Ekaterina Shatalina, Leigh Townsend, Ellis Chika Onwordi, Tsz Lun Allenis Mak, Atheeshaan Arumuham, Oisín O’Brien, Maria Lobo, Luke Vano, Uzma Zahid, Emma Butler, Martin Osugo
Journal: World Psychiatry (2021)

The idea that a longer duration of untreated psychosis (DUP) leads to poorer outcomes has contributed to extensive changes in mental health ser-vices worldwide and has attracted considerable research interest over the past 30 years. However, the strength of the evidence underlying this notion is unclear. To address this issue, we conducted an umbrella review of available meta-analyses and performed a random-effects meta-analysis of primary studies. MEDLINE, Web of Science, PsycINFO and EMBASE were searched from inception to September 3, 2020 to identify relevant meta-analyses of studies including patients with schizophrenia spectrum disorders, first-episode psychosis, or affective and non-affective psychosis. Thirteen meta-analyses were included, corresponding to 129 individual studies with a total sample size of 25,657 patients. We detected potential violations of statistical assumptions in some of these meta-analyses. We therefore conducted a new random-effects meta-analysis of primary studies. The association between DUP and each outcome was graded according to a standardized classification into convincing, highly suggestive, suggestive, weak, or non-significant. At first presentation, there was suggestive evidence for a relationship between longer DUP and more severe negative symptoms (beta=-0.07, p=3.6×10-5 ) and higher chance of previous self-harm (odds ratio, OR=1.89, p=1.1×10-5 ). At follow-up, there was highly suggestive evidence for a relationship between longer DUP and more severe positive symptoms (beta=-0.16, p=4.5×10-8 ), more severe negative symptoms (beta=-0.11, p=3.5×10-10 ) and lower chance of remission (OR=2.16, p=3.0×10-10 ), and suggestive evidence for a relationship between longer DUP and poorer overall functioning (beta=-0.11, p=2.2×10-6 ) and more severe global psychopathology (beta=-0.16, p=4.7×10-6 ). Results were unchanged when analysis was restricted to prospective studies. These effect sizes are clinically meaningful, with a DUP of four weeks predicting >20% more severe symptoms at follow-up relative to a DUP of one week. We conclude that DUP is an important prognostic factor at first presentation and predicts clinically relevant outcomes over the course of illness. We discuss conceptual issues in DUP research and methodological limitations of current evidence, and provide recommendations for future research.
Abstract 12643: Prognostic Value of Serum N-terminal Pro-brain Natriuretic Peptide for Sudden Cardiac Death Prediction in Patients With Hypertrophic Cardiomyopathy
Authors: Guixin Wu, Yubao Zou, Jie Liu, Limei Wang, Xiaolu Sun, Lianming Kang, Lei Song, Jizheng Wang
Journal: Circulation (2019)

Introduction: The prediction and risk classification for sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM) remain challenging. Our study aimed to ascertain the prognostic value of NT-...
Healthcare Resource Utilization and Sickness Absence in Newly Diagnosed Multiple Myeloma Patients in Sweden: Trends in a Changing Treatment Landscape
Authors: Fredrik Borgsten, Xenia Gatopoulou, Marta Pisini, Magnus Tambour, Frida Schain, Christina V Jones, Kelvin Ho Man Kwok, Catharina Hjortsberg, Magnus Björkholm
Journal: Blood (2020)
Real-World Characterization of Ibrutinib Therapy for Chronic Lymphocytic Leukemia (CLL) and Small Lymphocytic Lymphoma (SLL) Patients in British Columbia (BC)
Authors: Rania S. Khelifi, Steven J.T. Huang, Kerry J. Savage, Diego Villa, David W. Scott, Khaled Ramadan, Joseph M. Connors, Laurie H. Sehn, Cynthia L Toze, Alina S. Gerrie
Journal: Blood (2020)
A neural network-based algorithm for assessing the cleanliness of small bowel during capsule endoscopy
Authors: Aymeric Histace, Xavier Dray, Romain Leenhardt, Marc Souchaud, Guy Houist, Jean-Philippe Le Mouel, Jean-Christophe Saurin, Franck Cholet, Gabriel Rahmi, Chloé Leandri
Journal: Endoscopy (2020)

Cleanliness scores in small-bowel capsule endoscopy (SBCE) have poor reproducibility. The aim of this study was to evaluate a neural network-based algorithm for automated assessment of small-bowel cleanliness during capsule endoscopy.600 normal third-generation SBCE still frames were categorized as "adequate" or "inadequate" in terms of cleanliness by three expert readers, according to a 10-point scale, and served as a training database. Then, 156 third-generation SBCE recordings were categorized in a consensual manner as "adequate" or "inadequate" in terms of cleanliness; this testing database was split into two independent 78-video subsets for the tuning and evaluation of the algorithm, respectively.Using a threshold of 79 % "adequate" still frames per video to achieve the best performance, the algorithm yielded a sensitivity of 90.3 %, specificity of 83.3 %, and accuracy of 89.7 %. The reproducibility was perfect. The mean calculation time per video was 3 (standard deviation 1) minutes.This neural network-based algorithm allowing automatic assessment of small-bowel cleanliness during capsule endoscopy was highly sensitive and paves the way for automated, standardized SBCE reports.
Risk of radiation-induced fibrosis is associated with transcriptional response in irradiated subcutaneous fibroblasts from breast cancer patients
Authors: Jan Alsner, Jens Overgaard
Journal: Cancer Research (2007)

3922  Aim: To verify that radiation-induced transcriptional profiles in subcutaneous fibroblasts from breast cancer patients correlate with risk of radiation-induced fibrosis (RIF), a common long-term adverse effect of ionizing radiotherapy. Materials and methods: We have recently identified a genetic signature from irradiated fibroblasts which correlates with risk of RIF (Rodningen et al, submitted). An update of this signature is verified by real-time PCR in an extended and independent version of 27 patients from the cohort of breast cancer patients treated with post-mastectomy radiotherapy between 1978 and 1982. Results: A set of genes involved in cellular processes like extracellular matrix remodelling, cell adhesion, proliferation and ROS scavenging is differentially expressed in irradiated fibroblast (3 x 3.5 Gy / 2 days) from breast cancer patients and can identify a subset of patients with reduced risk of RIF. Dose-response curves for subcutaneous fibrosis generated for the identified two groups of patients demonstrate an enhancement ratio of 1.25 (1.12-1.40) for risk of RIF. Pathway analysis show that the classifier genes are primarily downstream of TGFβ1, TNFα, and p53. Only minor differences in transcriptional profiles are observed in unirradiated fibroblasts, and these do not correlate with risk of RIF. Conclusions: Knowledge about the underlying biological mechanisms of RIF is important in order to improve ionizing radiotherapy. Although the classifier itself may not be utilized as a predictive assay, it provides valuable new insight into the molecular mechanisms of RIF and identifies candidate genes for association studies between germline variations and risk of RIF.
Concurrent FLT3 Inhibitor and IDH Inhibitor Therapy in Patients with Acute Myeloid Leukemia (AML)
Authors: Amir T. Fathi, Alexander E. Perl, Mark Levis, Catherine C. Smith, Andrew M. Brunner, Koichi Takahashi, Philip C. Amrein, Hanno R. Hock, Gabriela S. Hobbs, Rupa Narayan, Jenna A. Moran, Meghan Bergeron, Julia E. Foster, Naval Daver, Courtney D. DiNardo
Journal: Blood (2020)
Two Phase 1b Studies Evaluating the Safety and Tolerability of BET Inhibitors, ABBV-744 and Mivebresib, as Monotherapies and in Combination with Ruxolitinib or Navitoclax in Patients with Myelofibrosis
Authors: John Mascarenhas, Rabih Saab, Deanna Brackman, Dimple A. Modi, Linu Abraham, James E. Ward, Srdan Verstovsek
Journal: Blood (2020)
Publisher Correction: Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing
Authors: Susie Suh, Elliot H. Choi, Henri Leinonen, Andrzej T. Foik, Gregory A. Newby, Wei-Hsi Yeh, Zhiqian Dong, Philip D. Kiser, David C. Lyon, David R. Liu, Krzysztof Palczewski
Journal: Nature Biomedical Engineering (2020)
Outcomes of Patients with Relapsed Mantle Cell Lymphoma Treated with Venetoclax: A Multicenter Retrospective Analysis
Authors: Yazeed Sawalha, Subir Goyal, Jeffrey M. Switchenko, Jason T. Romancik, Manali Kamdar, Irl Brian Greenwell, Brian T. Hess, Krista Isaac, Craig A. Portell, Alex V. Mejia Garcia, Scott R. Goldsmith, Natalie S Grover, Peter A. Riedell, Reem Karmali, Madelyn Burkart, Michael J Buege, Othman S. Akhtar, Pallawi Torka, Anita Kumar, Brian T. Hill, Brad S. Kahl, Jonathon B. Cohen
Journal: Blood (2020)
Chemotherapy or allogeneic transplantation in high-risk Philadelphia chromosome–negative adult lymphoblastic leukemia
Authors: Josep-Maria Ribera, Mireia Morgades, Juana Ciudad, Pau Montesinos, Jordi Esteve, Eulàlia Genescà, Pere Barba, Jordi Ribera, Irene García-Cadenas, María José Moreno, Daniel Martínez-Carballeira, Anna Torrent, Pilar Martínez-Sánchez, Silvia Monsalvo, Cristina Gil, Mar Tormo, María Teresa Artola, Marta Cervera, José González-Campos, Carlos Rodríguez, Arancha Bermúdez, Andrés Novo, Beatriz Soria, Rosa Coll, María-Luz Amigo, Aurelio López-Martínez, Rosa Fernández-Martín, Josefina Serrano, Santiago Mercadal, Antònia Cladera, Alberto Giménez-Conca, María-Jesús Peñarrubia, Eugènia Abella, Ferran Vall-llovera, Jesús-María Hernández-Rivas, Antoni Garcia-Guiñon, Juan-Miguel Bergua, Beatriz de Rueda, María-José Sánchez-Sánchez, Alfons Serrano, María Calbacho, Natalia Alonso, Jose-Ángel Méndez-Sánchez, Raimundo García-Boyero, Matxalen Olivares, Susana Barrena, Lurdes Zamora, Isabel Granada, Ludovic Lhermitte, Evarist Feliu, Alberto Orfao
Journal: Blood (2020)
Abstract 439: Trajectory Analysis of Left Ventricular Dimensions From Biobank Data Uncovers Novel Genetic Associations
Authors: Tess Pottinger, Megan J Puckelwartz, Lorenzo L Pesce, Anthony Gacita, Isabella Salamone, Samuel Kearns, Jennifer A Pacheco, Marcelo Nobrega, Laura J Rasmussen-Torvik, Maureen E Smith, Rex Chisholm, Elizabeth M McNally
Journal: Circulation Research (2020)

Background: Approximately 6 million adults in the United States have heart failure. The progression of heart failure is variable arising from differences in sex, age, genetic background including ancestry, and medication response. Many population-based genetic studies of heart failure have been cross-sectional in nature, failing to gain additional power from longitudinal analyses. As heart failure is known to change over time, using longitudinal data trajectories as a quantitative trait will increase power in genome wide association studies (GWAS). Methods: We used the electronic health record in a racially and ethnically diverse medical biobank from a single, metropolitan US center. We used whole genome data from 896 unrelated participants analyzed, including 494 who had at least 1 electrocardiogram and 324 who had more than 1 echocardiogram (average of 3 observations per person). A mixture model based semiparametric latent growth curve model was used to cluster outcome measures used for genome-wide analyses. Results: GWAS on the trajectory probability of QTc interval identified significant associations with variants in regulatory regions proximal to the WLS gene, which encodes Wntless, a Wnt ligand secretion mediator. WLS was previously associated with QTc and myocardial infarction, thus confirming the power of the method. GWAS on the trajectory probability of left ventricular diameter (LVIDd) identified significant associations with variants in regulatory regions near MYO10 , which encodes unconventional Myosin-10. MYO10 was previously associated with obesity and metabolic syndrome. Conclusions: This is the first study to show an association with variants in or near MYO10 and left ventricular dimension changes over time. Further, we found that using trajectory probabilities can provide increased power to find novel associations with longitudinal data. This reduces the need for larger cohorts, and increases yield from smaller, well-phenotyped cohorts, such as those found in biobanks. This approach should be useful in the study of rare diseases and underrepresented populations.