tbuckley/cabot-search huggingface dataset:
The Addition of Navitoclax to Ruxolitinib Demonstrates Efficacy within Different High-Risk Populations in Patients with Relapsed/Refractory Myelofibrosis
Authors: Naveen Pemmaraju, Jacqueline S. Garcia, Jalaja Potluri, Leanne Holes, Jason Harb, Paul Jung, Jessica E. Hutti, Josef T. Prchal, Srdan Verstovsek, Claire Harrison
Journal: Blood (2020)
Baseline Characteristics of Patients in Peak: A Global, Longitudinal Registry of Patients with Pyruvate Kinase Deficiency
Authors: Rachael F. Grace, Audra Boscoe, Chris Bowden, Bertil Glader, Hitoshi Kanno, D. Mark Layton, Eduard van Beers, Joan-Lluis Vives Corrons, Yan Yan, Paola Bianchi
Journal: Blood (2020)
Comprehensive guidance on the diagnosis and management of primary mesenchymal tumours of the thyroid gland
Authors: Sriram Gubbi, Shilpa Thakur, Shirisha Avadhanula, Katherine A Araque, Armando C Filie, Mark Raffeld, James Welch, Jaydira Del Rivero, Electron Kebebew, Kenneth D Burman, Leonard Wartofsky, Joanna Klubo-Gwiezdzinska
Journal: The Lancet Oncology (2020)
Climate change: challenges and opportunities to scale up surgical, obstetric, and anaesthesia care globally
Authors: Lina Roa, Lotta Velin, Jemesa Tudravu, Craig D McClain, Aaron Bernstein, John G Meara
Journal: The Lancet Planetary Health (2020)

Climate change affects human health in a myriad of ways, requiring reassessment of the nature of scaling up care delivery and the effect that care delivery has on the environment. 5 billion people do not have access to safe and timely surgical care, and the quantity and severity of conditions that require surgical, obstetric, and anaesthesia care will increase substantially as a result of climate change. However, surgery is resource intensive and contributes substantially to greenhouse-gas emissions. In response to climate change, the surgical, obstetric, and anaesthesia community has a key role to play to ensure that a scale-up of service delivery incorporates mitigation and adaptation strategies. As countries scale up surgical care, understanding the implications of surgery on climate change and the implications of climate change on surgical care will be crucial in the development of health policies.
Significant EBV Reactivation Is Associated with Poorer Overall Survival Due to Increased NRM Post Myeloablative/Reduced Intensity, T-Cell Deplete Allogeneic Stem Cell Transplant for MDS or Acute Leukaemia
Authors: Ashvind Anand Prabahran, James Anton Kuzich, Andrew B M Lim, Eric Wong, David Ritchie
Journal: Blood (2020)
An Immune Senescence and Exhaustion-Related RNA Profile Predicts Clinical Outcomes in Acute Myeloid Leukemia
Authors: Jayakumar Vadakekolathu, Tung On Yau, Heidi Altmann, Sarah E. Church, Hanna A Knaus, Mark D. Minden, Jan K Davidson-Moncada, Sarah K Tasian, Martin Bornhäuser, Ivana Gojo, Leo Luznik, Sergio Rutella
Journal: Blood (2020)
Abstract 536: Human Antigen R (HuR) in the Myofibroblasts is a Critical Regulator of Pressure-Overload Induced Cardiac Remodeling
Authors: Lisa Green, Sarah Anthony, Perwez Alam, Michael Tranter
Journal: Circulation Research (2020)

Cardiac fibrosis is characterized by the excessive deposition of extracellular matrix (ECM) and is an important target because excess ECM leads to a stiffened myocardium and worsens the prognosis of heart failure. Human Antigen R (HuR) is an RNA binding protein known to stabilize mRNA through binding to AU rich regions in the 3’UTR, and we have previously shown HuR to play a central role in the development of cardiac hypertrophy. To interrogate the role of HuR in cardiac fibrosis, we used both a small molecule inhibitor of HuR as well as an inducible genetic deletion of HuR in the activated cardiac myofibroblasts (iMF-HuR -/- ). Results using an in vitro scratch assay showed that primary adult cardiac fibroblasts treated with a small molecule inhibitor of HuR display a delayed wound healing response concomitant with a reduced expression of ECM remodeling genes. In vivo , we used an 8-week TAC (transverse aortic constriction) model of pressure overload to induce pathological cardiac remodeling. We hypothesized that deleting HuR in the activated fibroblasts would dampen myofibroblast-mediated ECM remodeling leading to a less stiff myocardium with reduced fibrotic burden and improved cardiac function in iMF-HuR -/- mice following pressure overload (TAC). However, echocardiography results show that cardiac function declined more rapidly in iMF-HuR -/- following TAC. The iMF-HuR -/- mice also had significantly enlarged hearts compared to the controls indicated by the heart weight/tibia length ratio. This suggests a critical role for HuR and myofibroblast activity in the early response to pressure overload. Future studies will focus on determining how the fibroblasts and the ECM composition/stiffness affect myocyte function in the early cardiac remodeling phase post-TAC and how HuR is involved in this relationship.
Health-Related Quality of Life Outcomes for Patients with Transfusion-Dependent Beta-Thalassemia Treated with Luspatercept in the Believe Trial
Authors: Maria Domenica Cappellini, Ali T. Taher, Antonio Piga, Farrukh Shah, Ersi Voskaridou, Vip Viprakasit, John B. Porter, Olivier Hermine, Ellis J. Neufeld, Alexis A. Thompson, Derek Tang, Peiwen Yu, Shien Guo, Jeevan K. Shetty, Dimana Miteva, Tatiana Zinger, Jay T. Backstrom, Esther Natalie Oliva
Journal: Blood (2020)
Abstract 15578: Does Renal Denervation Effectively Reduce the Silent Killer? A Systematic Review and Meta-Analysis
Authors: Waqas J Siddiqui, Muhammad Shabbir Rawala, Muhammad Zain, Waqas Abid, Murrium Sadaf, Danish abbasi, Mohammad H Khan, Omer Zuberi
Journal: Circulation (2019)

Introduction: Hypertension is also known as the “silent killer” has been associated with significant morbidity and mortality due to myocardial infarction, cardiomyopathy, heart failure, renal failu...
NSD2-E1099K Mutation Leads to Glucocorticoid-Resistant B Cell Lymphocytic Leukemia in Mice
Authors: Jianping Li, Crissandra Piper, Daphne Dupere-Richer, Heidi Casellas Roman, Alok Swaroop, Catalina Troche, Jon Oyer, Christine Will, Alberto Riva, Richard Lynn Bennett, Jonathan D. Licht
Journal: Blood (2020)
Expression of <i>Sf3b1-K700E</i> accelerates the Development of Chronic Lymphocytic Leukemia in a <i>Del</i>(13q) Murine Model
Authors: Bo Zhang, Prajish Iyer, Meiling Jin, Elisa Ten Hacken, Zachary Cartun, Kevyn Hart, Laura Z. Rassenti, Thomas J. Kipps, Donna S. Neuberg, Ruben D. Carrasco, Catherine J. Wu, Lili Wang
Journal: Blood (2020)
THU0019 Intracellular expression of cxcr3 on rheumatoid arthritis synovial tissue cells
Authors: O Krystufkova, J Vencovsky, S Ruzickova, J Sinkora, Z Rehakova, J Niederlova, CA Power, C Plater-Zyberk
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> Inflammatory cell infiltration and synovial activation are important processes in rheumatoid arthritis. Chemotactic gradients of various chemokines are responsible for cell attraction and possibly for their activation. We have previously detected strong expression of chemokine receptor CXCR3 in the rheumatoid joint by immunostaining. <h3>Objectives</h3> Characterisation of the cells expressing CXCR3 in RA synovial membrane. <h3>Methods</h3> Synovial tissue samples were obtained from RA patients undergoing either synovectomy or a total joint replacement. Cells were released by digestion with collagenase, DNAse and briefly with hyaluronidase. A three colour fluorescence analysis was performed with FITC conjugated anti-CXCR3 mouse MAb (R&amp;D) and with a panel of phycoerythrin (PE) conjugated MAb (anti-CD3, CD4, CD8, CD19, CD55, CD31, CD68, CD14 and CD45). Live cells were identified by propidium iodide. PBCs were stained using the same protocol. <h3>Results</h3> As expected, a proportion of CD3<sup>+</sup> and CD4<sup>+</sup> blood and synovial cells was CXCR3 positive. In addition, CXCR3 was also seen in synovial cells positive for CD55, CD14, CD8 and to a less extent CD31. However, in contrast to the surface staining of cells from peripheral blood, CXCR3 staining was identified only intracellularly in synovial cells. No CXCR3 staining could be detected on the surface of any type of viable synovial cell, including CD3 positive lymphocytes. <h3>Conclusion</h3> Flow cytometry identifies synovial cells that display intracellular CXCR3 staining. These cells are comprised of T lymphocytes, macrophages, possibly synovial fibroblasts and endothelial cell populations. The intracellular presence of CXCR3 suggests a possible internalisation of this molecule, which may be a consequence of ligand binding. The significance of this phenomenon and of CXCR3 expression in cell types other than leukocytes remains to be determined. This work was supported by a grant NI/6459 from IGA MZ CR.
Loss of Endogenously Cycling Adult Cardiomyocytes Worsens Myocardial Function
Authors: Leigh A. Bradley, Alexander Young, Hongbin Li, Helen O. Billcheck, Matthew J. Wolf
Journal: Circulation Research (2020)

Endogenously cycling adult cardiomyocytes increase after myocardial infarction (MI) but remain scarce and are generally thought not to contribute to myocardial function. However, this broadly held assumption has not been tested, mainly because of the lack of transgenic reporters that restrict Cre expression to adult cardiomyocytes that reenter the cell cycle.
Increasing Doses of Anticoagulation Are Associated with Improved Survival in Hospitalized COVID-19 Patients
Authors: Filip Ionescu, Girish B Nair, Ioana Petrescu, Anish S Konde, Markie Sue Zimmer, Nwabundo Anusim, Vishal Jindal, Susanna Gaikazian, Joseph Anderson, Michael Stender, Marianne Terese Huben, Ishmael Jaiyesimi
Journal: Blood (2020)
Outcomes of Patients with Large B-cell Lymphoma Progressing after Axicabtagene Ciloleucel
Authors: Jay Y Spiegel, Saurabh Dahiya, Michael D. Jain, John S Tamaresis, Loretta Nastoupil, Miriam T Jacobs, Armin Ghobadi, Yi Lin, Matthew Lunning, Lazaros John Lekakis, Patrick Reagan, Olalekan O Oluwole, Joseph P McGuirk, Abhinav Deol, Andre Goy, Khoan Vu, Charalambos Andreadis, Javier Munoz, N. Nora Bennani, Julie Vose, Kathleen A Dorritie, Sattva S. Neelapu, Frederick L. Locke, Aaron P. Rapoport, Brian Hill, David B Miklos
Journal: Blood (2020)
Predictors of Early Mortality, Response, and Survival in Newly Diagnosed Acute Myeloid Leukemia (AML) Using a Contemporary Academic Cohort
Authors: Patrick K Reville, Graciela M. Nogueras González, Farhad Ravandi, Koji Sasaki, Gautam Borthakur, Guillermo Garcia-Manero, Naval Daver, Courtney D. DiNardo, Elias Jabbour, Naveen Pemmaraju, Michael Andreeff, Srdan Verstovsek, Alessandra Ferrajoli, Nitin Jain, Maro Ohanian, Sherry A. Pierce, Zeev E. Estrov, Marina Konopleva, Hagop M. Kantarjian, Tapan M. Kadia
Journal: Blood (2020)
AB0634 BUDGET IMPACT ANALYSIS OF BIOLOGICAL THERAPY COMPARED TO CONVENTIONAL SPONDYLOARTHRITIS TREATMENT, IN A FOURTH LEVEL HOSPITAL IN BOGOTA COLOMBIA
Authors: J. M. Bello-Gualtero, O. J. Calixto, G. Salguedo, Y. M. Chamorro-Melo, C. A. Camargo Rodríguez, H. Quitian Ruiz, A. Beltrán, G. Saavedra
Journal: Annals of the Rheumatic Diseases (2020)

Background: Spondyloarthritis refers to a family of diseases, of which ankylosing spondylitis and non-radiographic axial spondyloarthritis are responsible for axial impairment. Previously, the only treatment available were NSAIDs, which control activity and stop radiological progression, but at the expense of increased adverse effects, such as cardiovascular risk, dyspepsia and chronic renal failure. For the past 2 decades, biological therapy has been available, which means an increase in care costs. Objectives: The objective of this study is to perform a budget impact analysis of biologic therapy. Methods: To do a budget impact analysis from the perspective of the payer, comparing biological therapy with coventional therapy for the treatment of spondyloarthritis. Demographic characterization of the population attended at the Central Military Hospital. Time horizon from 2012 to 2018, taking the activity count according to the hospital’s billing and the prices of the activities of the state body SISMED. Exchange rates at the end of 2018. Results: The patients attended were 117, mostly men (63, 25%), average age 46, 4 years (SD 13), with disease diagnosis time of 9, 8 years (SD 9, 6). In the budget impact analysis, it is observed that 25% of patients were on DMARDs therapy, 22% with NSAIDs and 96% with biologic therapy. The average year/patient cost with NSAIDs alone would be EUR 381, with DMARDs only EUR 9,318 and, if only biological therapy was used, EUR 423. Within the total number of patients, the average annual cost, including the possibility of combining these drugs, amounted to EUR 5,403 Conclusion: Including biological therapy in the care of patients with spondyloarthritis can increase up to 24 times the annual cost per patient. This increase is not only due to higher market value, it also relates to the need for more medical procedures and diagnostic follow-up tests. References: [1]Strömbeck, et al. Cost of Illness from the Public Payers’ Perspective in Patients with Ankylosing Spondylitis in Rheumatological Care. J Rheumatol 2010;37;2348-2355. Disclosure of Interests: None declared
Single-Cell Transcriptomic Profiling of De Novo and Relapsed Acute Myeloid Leukemia Identifies a Leukemic Stemness Program Shared across Diverse Phenotypes
Authors: Samantha Worme, Selin Jessa, William Poon, Maja Jankovic, Gabriela Galicia Vazquez, Alexandre Bazinet, Katharine Fooks, Isabella Iasenza, Patricia Arreba-Tutusaus, Kolja Eppert, Ioannis Ragoussis, Yu Chang Wang, Nathalie A Johnson, Sarit E Assouline, Claudia L Kleinman, François E Mercier
Journal: Blood (2020)
Covid-19: Experts debate merits of lockdowns versus “focused protection”
Authors: Jeanne Lenzer
Journal: BMJ (2020)

Three experts with widely differing viewpoints regarding appropriate public health measures to control the spread of covid-19 weighed in on lockdowns during a debate 1 sponsored by Johns Hopkins University.The experts represented viewpoints ranging from advocacy for "focused protection" as described in the Great Barrington Declaration 2 to recommendations for population-wide mandates as described in the John Snow Memorandum. 3
Outcome of Adults with Relapsed T-Cell Acute Lymphoblastic Leukemia (T-ALL) Included in Minimal Residual Disease (MRD)-Oriented Trials
Authors: Josep-Maria Ribera, Eduardo Cerello Chapchap, Mireia Morgades, Eulàlia Genescà, Cristina Gil, Irene García-Cadenas, Pere Barba, José González-Campos, Anna Torrent, Teresa Bernal del Castillo, Maria Paz Queipo De Llano, María-Luz Amigo, Mar Tormo, Rosa Coll, Ferran Vall-Llovera, Jordi Ribera, Maria Jose Sanchez, Beatriz Soria, Antonia Cladera, María Teresa Artola, Antoni Garcia-Guiñon, Alberto Giménez Conca, Lourdes Amador Barciela, Juana Ciudad, Alberto Orfao
Journal: Blood (2020)
Suboptimal moxifloxacin and levofloxacin drug exposure during treatment of patients with multidrug-resistant tuberculosis: results from a prospective study in China
Authors: Lina Davies Forsman, Katarina Niward, Johanna Kuhlin, Xubin Zheng, Rongrong Zheng, Ran Ke, Chao Hong, Jim Werngren, Jakob Paues, Ulrika S.H. Simonsson, Erik Eliasson, Sven Hoffner, Biao Xu, Jan-Willem Alffenaar, Thomas Schön, Yi Hu, Judith Bruchfeld
Journal: European Respiratory Journal (2020)

<b>This study found target attainment of 0–55% for patients with multidrug-resistant TB using currently recommended doses of moxifloxacin (55%) and levofloxacin (0%), meaning increased doses should be considered to ensure efficacy, if safety can be assured</b> https://bit.ly/3juED6S
CAR T-Cell Therapy in Relapsed/Refractory Diffuse Large B-Cell Lymphoma (R/R DLBCL): A 'Real-World' Analysis of Patterns of Failure and Role of Bridging Therapy
Authors: Revathi Ravella, Elizabeth Ren Zhang-Velten, Farrukh T Awan, Syed M Rizvi, Jennifer L Shah, Neil B Desai, Praveen Ramakrishnan Geethakumari, Kiran A Kumar
Journal: Blood (2020)
Shared Expression of CD93 and Other Antigens By AML and Endothelial Cells Highlights a Need for Rational Combinatorial Targeting
Authors: Rebecca M Richards, Feifei Zhao, Katherine A Murphy, Peng Xu, Amy Fan, Elena Sotillo, Mads Daugaard, Htoo Zarni Oo, Jie Liu, Wan-Jen Hong, Poul Sorensen, Robbie G. Majzner, Ravi Majeti, Crystal L. Mackall
Journal: Blood (2020)
Sialylated Glycans Regulate MUC13 and the Proto-Oncogenes Pim-1 and Myc to Control Hematopoietic Stem and Progenitor Cell Numbers
Authors: Leonardo Rivadeneyra, Melissa M. Lee-Sundlov, Simon Glabere, Heather Ashwood, Robert Burns, Karin M. Hoffmeister
Journal: Blood (2020)
PBSC Mobilization for Auto-HSCT in Myeloma: Growth Factors Vs Growth Factors + Chemotherapy
Authors: Jeremy L. Ramdial, Junsheng Ma, Denai R. Milton, Ruby Delgado, Qaiser Bashir, Samer A. Srour, Neeraj Saini, Yago Nieto, Chitra Hosing, Uday R. Popat, Regan Murphy, Hans C. Lee, Krina K. Patel, Elisabet E. Manasanch, Sheeba K. Thomas, Gregory P. Kaufman, Donna M. Weber, Robert Z. Orlowski, Richard E. Champlin, Muzaffar H. Qazilbash
Journal: Blood (2020)
Open Label, Multicenter, Dose-Escalation/ Expansion Phase Ib Study to Evaluate Safety and Activity of BET Inhibitor RO6870810 (RO), Given As Monotherapy to Patients (pts) with Advanced Multiple Myeloma
Authors: Karthik Ramasamy, Ajay Nooka, Hang Quach, Myo Htut, Rakesh Popat, Michaela Liedtke, Sascha A Tuchman, Jacob P. Laubach, Cristina Gasparetto, Asher A. Chanan-Khan, Mark Hertzberg, Mark Demario, Eveline Nueesch, Evelyne Chesne, Izolda Franjkovic, Katharina Lechner, Martin Kornacker, Hearn Jay Cho
Journal: Blood (2020)
Resolvin D3 controls mouse and human TRPV1-positive neurons and preclinical progression of psoriasis
Authors: Sang Hoon Lee, Raquel Tonello, Sang-Taek Im, Hawon Jeon, Jeongsu Park, Zachary Ford, Steve Davidson, Yong Ho Kim, Chul-Kyu Park, Temugin Berta
Journal: Theranostics (2020)

Psoriasis is a chronic inflammatory disease caused by a complex interplay between the immune and nervous systems with recurrent scaly skin plaques, thickened stratum corneum, infiltration and activation of inflammatory cells, and itch. Despite an increasing availability of immune therapies, they often have adverse effects, high costs, and dissociated effects on inflammation and itch. Activation of sensory neurons innervating the skin and TRPV1 (transient receptor potential vanilloid 1) are emerging as critical components in the pathogenesis of psoriasis, but little is known about their endogenous inhibitors. Recent studies have demonstrated that resolvins, endogenous lipid mediators derived from omega-3 fatty acids, are potent inhibitors of TRP channels and may offer new therapies for psoriasis without known adverse effects.
Complex Karyotype Is a Significant Predictor for Worst Outcomes in Patients with Mantle Cell Lymphoma (MCL) Treated with BTK Inhibitors - Comprehensive Analysis of 396 Patients
Authors: Preetesh Jain, Guilin Tang, C. Cameron Yin, Chi Young Ok, Lucy Navsaria, Maria Badillo, Wendy Chen, Yijing Li, Yuxuan Che, Yang Liu, Onyeka Oriabure, Graciela M. Nogueras González, Jason Westin, Loretta J. Nastoupil, Sairah Ahmed, Ranjit Nair, Selvi Thirumurthi, Shaoying Li, Rashmi Kanagal-Shamanna, Francisco Vega, Christopher Flowers, Michael Wang
Journal: Blood (2020)
The transcription factor IRF4 represses proapoptotic BMF and BIM to licence multiple myeloma survival
Authors: Pasquale L. Fedele, Yang Liao, Jia-nan Gong, Yuan Yao, Mark F. van Delft, Michael S. Y. Low, Lin Tai, Marco J. Herold, Jacob T. Jackson, Charis E. Teh, Tania Tan, Lorraine A. O’Reilly, Julie Tellier, George Grigoriadis, David C. S. Huang, Wei Shi, Stephen L. Nutt, Simon N. Willis
Journal: Leukemia (2020)
Evaluating Hypertrophic Cardiomyopathy Disease-Gene Associations Using the Clinical Genome Resource (ClinGen) Gene Curation Framework
Authors: J Ingles, J Goldstein, C Caleshu, E Corty, S Crowley, K Dougherty, J McGlaughon, L Milko, A Morales, B Seifert, C Semsarian, N Strande, C Thaxton, K Thomson, P van Tintelen, K Wallace, R Walsh, J Ware, Q Wells, N Whiffin, L Wikowski, R Hershberger, B Funke
Journal: Circulation (2017)
Development and Performance of a Clinical Decision Support Tool to Inform Resource Utilization for Elective Operations
Authors: Benjamin A. Goldstein, Marcelo Cerullo, Vijay Krishnamoorthy, Jeanna Blitz, Leila Mureebe, Wendy Webster, Felicia Dunston, Andrew Stirling, Jennifer Gagnon, Charles D. Scales
Journal: JAMA Network Open (2020)

<h3>Importance</h3> Hospitals ceased most elective procedures during the height of coronavirus disease 2019 (COVID-19) infections. As hospitals begin to recommence elective procedures, it is necessary to have a means to assess how resource intensive a given case may be. <h3>Objective</h3> To evaluate the development and performance of a clinical decision support tool to inform resource utilization for elective procedures. <h3>Design, Setting, and Participants</h3> In this prognostic study, predictive modeling was used on retrospective electronic health records data from a large academic health system comprising 1 tertiary care hospital and 2 community hospitals of patients undergoing scheduled elective procedures from January 1, 2017, to March 1, 2020. Electronic health records data on case type, patient demographic characteristics, service utilization history, comorbidities, and medications were and abstracted and analyzed. Data were analyzed from April to June 2020. <h3>Main Outcomes and Measures</h3> Predicitons of hospital length of stay, intensive care unit length of stay, need for mechanical ventilation, and need to be discharged to a skilled nursing facility. These predictions were generated using the random forests algorithm. Predicted probabilities were turned into risk classifications designed to give assessments of resource utilization risk. <h3>Results</h3> Data from the electronic health records of 42 199 patients from 3 hospitals were abstracted for analysis. The median length of stay was 2.3 days (range, 1.3-4.2 days), 6416 patients (15.2%) were admitted to the intensive care unit, 1624 (3.8%) received mechanical ventilation, and 2843 (6.7%) were discharged to a skilled nursing facility. Predictive performance was strong with an area under the receiver operator characteristic ranging from 0.76 to 0.93. Sensitivity of the high-risk and medium-risk groupings was set at 95%. The negative predictive value of the low-risk grouping was 99%. We integrated the models into a daily refreshing Tableau dashboard to guide decision-making. <h3>Conclusions and Relevance</h3> The clinical decision support tool is currently being used by surgical leadership to inform case scheduling. This work shows the importance of a learning health care environment in surgical care, using quantitative modeling to guide decision-making.
DNMT3A Mutations Identify a Prognostic Subgroup in Peripheral T-Cell Lymphoma
Authors: Tyler A. Herek, Alyssa Bouska, Waseem G. Lone, Tayla B. Heavican, Catalina Amador, Sunandini Sharma, d'Amore Francesco, Wing C. Chan, Javeed Iqbal
Journal: Blood (2020)
A lump in the throat: laryngopharyngeal reflux
Authors: Nick J I Hamilton, Jane Wilcock, Saiful Alam Hannan
Journal: BMJ (2020)

### What you need to know Laryngopharyngeal reflux (LPR) is a common condition accounting for approximately 10% of all "ear, nose and throat" (ENT) referrals.1 It is caused by gastric contents passing up through the oesophagus and upper oesophageal sphincter resulting in macroscopic and microscopic inflammatory changes to the upper aerodigestive mucosa.2 This most commonly leads to the sensation of a lump in the throat, termed globus pharyngeus (box 1), as well as chronic throat clearing, excessive mucus, vocal hoarseness, and cough.3 This article offers an overview of the assessment and management of LPR. Box 1 ### Globus pharyngeusRETURN TO TEXT
Insufficient Mitral Leaflet Remodeling in Relation to Annular Dilation and Risk of Residual Mitral Regurgitation After MitraClip Implantation
Authors: Kensuke Hirasawa, Farnaz Namazi, Stephan Milhorini Pio, N. Mai Vo, Nina Ajmone Marsan, Jeroen J. Bax, Victoria Delgado
Journal: JACC. Cardiovascular imaging (2020)