tbuckley/cabot-search huggingface dataset:
Abstract 485: Enhanced Chaperone Mediated Autophagy in Cardiomyocytes Ameliorates Pathology Induced by Hypoxic and Proteotoxic Stresses
Authors: Rajeshwary Ghosh, J S Pattison
Journal: Circulation Research (2018)

Rationale: Protein degradation pathways play a critical role in maintaining cardiac homeostasis. Chaperone mediated autophagy (CMA) is a protein degradation pathway unique to mammalian cells, but little is known about CMA in cardiac disease. Preliminary studies in our lab showed increased CMA activity in mouse hearts subjected to MI (1.81 fold) and TAC surgery (3.5 fold), as well as, in hearts from mutant CryAB R120G transgenic mice (3 fold). Thus, we hypothesized that CMA plays a critical role in hypoxia- and proteotoxicity-induced cardiac stresses. CMA selectively targets substrate proteins for lysosomal degradation using CMA-specific lysosome membrane protein type 2a (LAMP2a) receptor. LAMP2a is both necessary and sufficient for CMA activity. Methods: An adenovirus and a siRNA were created to overexpress and silence LAMP2a levels to study the gain and loss of CMA in neonatal rat ventricular cardiomyocytes (NRVMs). Two models of cardiomyocyte stress were employed: 1) a hypoxic stress model that exposed NRVMs to CoCl 2 , a hypoxia mimetic agent; and 2) a proteotoxic model where mutant CryAB R120G , a missense mutation of αB-crystallin, was expressed causing the accumulation of insoluble protein aggregates. A more specific measure of CMA activity was also determined in lysosomal fractions of NRVMs. Results: The LAMP2a adenovirus and siRNA showed successful increase and knockdown of LAMP2a levels in NRVMs, respectively. CoCl 2 -induced hypoxia significantly increased CMA activity in NRVMs (26%). LAMP2a overexpression further augmented CoCl 2 -induced CMA activity (55%) and increased the percent of CMA-active lysosomes. LAMP2a siRNA blunted the CoCl 2 -induction of LAMP2a protein levels (65%) and silenced CMA activity in intact lysosomes. Further, CoCl 2 increased apoptosis which was rescued by enhanced CMA activity as shown by TUNEL staining. Thus, CMA is regulated by hypoxic stress and modulates cardiac cell survival. In a proteotoxic model, CryAB R120G and LAMP2a co-infection decreased CryAB R120G protein levels and insoluble aggregate pathology. Our data suggest that CMA may be cardioprotective against hypoxic and proteotoxic stresses. Impact: Defining the role of CMA in the heart could open new therapeutic pathways for the treatment of heart failure.
SOCIAL DETERMINANTS OF HEALTH AND CLINICAL HYPERTENSION AND DIABETES PREVALENCE ON CHICAGO'S SOUTH SIDE
Authors: Marynia Kolak, Rhys Chua, Isaac Kamber, Elizabeth L. Tung, Stephanie Besser, Emeka Anyanwu, James Liao, Luc Anselin, Corey Tabit
Journal: Journal of the American College of Cardiology (2019)
LOW FLUOROSCOPY PERMANENT HIS BUNDLE PACING UTILIZING ELECTRO-ANATOMIC MAPPING: A COMPARISON WITH CONVENTIONAL HIS BUNDLE IMPLANTATION
Authors: Parikshit S. Sharma, Henry Huang, Richard Trohman, Angela Naperkowski, Kenneth Ellenbogen, Pugazhendhi Vijayaraman
Journal: Journal of the American College of Cardiology (2019)
PRE- VERSUS POST-PROCEDURE CLINICAL EVENT RATES AND ASSOCIATED HEALTHCARE RESOURCE UTILIZATION IN PATIENTS UNDERGOING COMMERCIAL MITRACLIP PLACEMENT
Authors: Sreekanth Vemulapalli, Morgan Cox, Zhuokai Li, Muath Bishawi, Andrzej Kosinski, David Cohen, Andrew Wang, Samir Kapadia, Paul Sorajja, Vinay Badhwar, Vinod Thourani, Donald Glower
Journal: Journal of the American College of Cardiology (2019)
VALIDATION OF A HEART FAILURE RISK ASSESSMENT TOOL IN A LARGE CONTEMPORARY ELECTRONIC HEALTH RECORD POPULATION
Authors: Aakash Bavishi, Hongyan Ning, Peter Glynn, Faraz Ahmad, Clyde Yancy, Sanjiv Shah, Laura Rasmussen-Torvik, Donald Lloyd-Jones, Sadiya Khan
Journal: Journal of the American College of Cardiology (2019)
PREVALENCE OF NEOATHEROSCLEROSIS IN VERY LATE FOLLOW-UP OF SECOND-GENERATION DRUG-ELUTING STENTS
Authors: Zhaoyang Chen, Mitsuaki Matsumura, Gary Mintz, Masahiko Noguchi, Mingyou Zhang, Lei Song, Dong Yin, Ziad Ali, Craig Porter, Elizabeth Haag, Jane Cao, Allen Jeremias, Richard Shlofmitz, Akiko Maehara
Journal: Journal of the American College of Cardiology (2019)
LEFT ATRIAL ASSIST DEVICE: A NEW DEVICE TO TREAT PATIENTS WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION
Authors: Kiyotaka Fukamachi, David J. Horvath, Jamshid Karimov, Nicole Byram, Joseph Adams, Yuichiro Kado, Takuma Miyamoto, Barry Kuban, Randall Starling
Journal: Journal of the American College of Cardiology (2019)
EXPOSURE TO HEAVY METALS MAY INCREASE CARDIOVASCULAR RISK BY ELEVATION OF SERUM LIPID LEVELS AND HEMOGLOBIN A1C: A NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY BASED STUDY
Authors: Olajide Buhari, Adebayo Atanda, Talal Alzharani, Robert Faillace
Journal: Journal of the American College of Cardiology (2019)
CLINICAL IMPACT OF POST PROCEDURAL FUNCTIONAL MITRAL REGURGITATION AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Eyal Ben-Assa, Simon Biner, Yaron Arbel, Sammy Elmariah, Shmuel Banai, Gad Keren, Ariel Finkelstein, Yan Topilsky
Journal: Journal of the American College of Cardiology (2019)
IMPACT OF VARIANT PULMONARY VENOUS ANATOMY ON THE EFFICACY OF ATRIAL FIBRILLATION ABLATION
Authors: Neil Phillips, Mohammad-Ali Jazayeri, Thomas McCormack, Tawseef Dar, Bharath Yarlagadda, Michael Pierpoline, Madhu Reddy, Martin P. Emert, Rhea C. Pimentel, Raghu Dendi, Loren Berenbom, Seth Sheldon
Journal: Journal of the American College of Cardiology (2019)
CHARACTERISTICS AND OUTCOMES OF PATIENTS WITH DOCUMENTED STRESS INDUCED (TAKOTSUBO) CARDIOMYOPATHY: A TERTIARY CARE CENTER EXPERIENCE
Authors: Alaa Alashi, Jackson Faulx, Venu Menon, Samir Kapadia, Stephen Ellis, Michael Faulx, Brian Griffin, Milind Desai
Journal: Journal of the American College of Cardiology (2019)
CARDIAC STRUCTURAL CHANGES AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT (TAVR): SYSTEMATIC REVIEW AND META-ANALYSIS OF MAGNETIC RESONANCE IMAGING (MRI) STUDIES
Authors: Ghazaleh Mehdipoor, Shmuel Chen, Saurav Chatterjee, Pooya Torkian, Ori Ben-Yehuda, Gregg Stone, Martin Prince
Journal: Journal of the American College of Cardiology (2019)
Abstract 226: Statin Therapy is Associated With Decreased Neovascularization in Symptomatic Carotid Atherosclerotic Plaque: A Pathological Analysis
Authors: Takao Konishi, Shinya Tanaka
Journal: Circulation Research (2018)

Background: Statin treatment has been shown to be associated with decreased intraplaque neovascularization in human carotid arteries by various imaging modalities or in animal models by pathological analysis. However, whether statin treatment attenuates intraplaque neovascularization in human carotid plaque has not been fully described. The aim of this study was to analyze the possible relationships between statin treatment and intraplaque microvessels (MVs) in patients undergoing carotid endarterectomy (CEA). Methods: Among consecutive 79 patients with advanced carotid artery stenosis (&gt;70%) between May 2015 and February 2017, 66 patients without statin therapy (group 1) and 13 patients with statin therapy (group 2) were analyzed. The specimens were stained with hematoxylin/eosin and elastica-Masson. Immunohistochemistry was performed, using an endothelial specific antibody to CD31, CD34 and PDGFRβ. The number of intraplaque MVs was analyzed in each specimen. MV density was defined as number of MVs per mm 2 . Results: The mean number of MVs was fewer in group 2 when compared with that in group 1 (25.8±17.6 vs. 50.8±31.8 /section, P&lt;0.001). The mean MV density was lower in group 2 when compared with that in group 1 (1.06±0.84 vs. 2.19±1.43 /mm 2 , P&lt;0.001). There was no significant difference in the mean concentration of low-density lipoprotein cholesterol between group 1 and group 2 (121±32 mg/dl vs. 105±37 mg/dl, P=0.118). Conclusions: This pathological analysis of carotid atherosclerotic plaque suggests that statin therapy is associated with decreased intraplaque neovascularization in symptomatic patients undergoing CEA. This plaque stability might be derived from pleiotropic effect beyond lipid lowering of statin therapy.
How to serve our ethnic minority communities better
Authors: Swaran P Singh
Journal: The Lancet Psychiatry (2019)

On Jan 9, 2017, Theresa May, the British Prime Minister, gave a speech about "the burning injustice of mental illness", mentioning "injustices in the way black people with mental ill health in particular are treated", and promising that politicians would "take action to put things right."1 In response to three decades of UK research on ethnic differences in mental health, such emotionally charged rhetoric has been commonplace, but has rarely produced meaningful change. Mental health care in ethnic minorities is complex, and needs dispassionate and objective scrutiny of evidence and its limitations, with careful disentanglement of the interactions between ethnicity, culture, community histories, legacies of racism, and the labyrinthine service structures that people with mental illness and their families must navigate to get appropriate help.
Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy
Authors: Meike E. W. Logtenberg, J. H. Marco Jansen, Matthijs Raaben, Mireille Toebes, Katka Franke, Arianne M. Brandsma, Hanke L. Matlung, Astrid Fauster, Raquel Gomez-Eerland, Noor A. M. Bakker, Simone van der Schot, Koen A. Marijt, Martijn Verdoes, John B. A. G. Haanen, Joost H. van den Berg, Jacques Neefjes, Timo K. van den Berg, Thijn R. Brummelkamp, Jeanette H. W. Leusen, Ferenc A. Scheeren, Ton N. Schumacher
Journal: Nature Medicine (2019)
Reduced-dose combination chemotherapy (S-1 plus oxaliplatin) versus full-dose monotherapy (S-1) in older vulnerable patients with metastatic colorectal cancer (NORDIC9): a randomised, open-label phase 2 trial
Authors: Stine Braendegaard Winther, Gabor Liposits, Halla Skuladottir, Eva Hofsli, Carl-Henrik Shah, Laurids Østergaard Poulsen, Jesper Ryg, Pia Osterlund, Åke Berglund, Camilla Qvortrup, Bengt Glimelius, Halfdan Sorbye, Per Pfeiffer
Journal: The Lancet. Gastroenterology & hepatology (2019)
EFFECT OF DIFFERENT POSTERIOR MITRAL VALVE LEAFLET PROLAPSE REPAIR TECHNIQUES ON POSTOPERATIVE LEFT VENTRICULAR GLOBAL LONGITUDINAL STRAIN
Authors: Anton Tomsic, Aniek L. van Wijngaarden, Jeroen J. Bax, Victoria Delgado, Robert Klautz, Nina Marsan, Meindert Palmen
Journal: Journal of the American College of Cardiology (2019)
RELATIONSHIP BETWEEN LIPID BURDEN DETECTED BY NEAR-INFRARED SPECTROSCOPY AND VULNERABLE PLAQUE FEATURES BY MULTIDETECTOR COMPUTED TOMOGRAPHY
Authors: Masahiro Hada, Yoshihisa Kanaji, Tomoki Horie, Haruhito Yuki, Hidenori Hirano, Yoshinori Kanno, Hiroaki Ohya, Yohei Sumino, Masao Yamaguchi, Masahiro Hoshino, Akinori Sugano, Taishi Yonetsu, Tsunekazu Kakuta
Journal: Journal of the American College of Cardiology (2019)
DIASTOLIC FILLING AND CLINICAL OUTCOMES: A PROSPECTIVE CARDIAC MAGNETIC RESONANCE STUDY
Authors: Yuchi Han, Joyce Han, Yue Wang, Ying Zhang, Jonathan Lee, Prasad Konda, Arpita Suri, Sowmya Gaddam, Zoubair Ahmed, Scott Akers, Julio Chirinos
Journal: Journal of the American College of Cardiology (2019)
PROGNOSTIC UTILITY OF A MODIFIED HEART SCORE WHEN DIFFERENT TROPONIN CUT-POINTS ARE USED
Authors: Lindsey Aurora, Richard Nowak, Christian Mueller, Giannitsis Evangelos, Robert Christenson, Christopher DeFilippi, Bertil Lindahl, Michael Christ, Richard Body, Gordon Jacobsen, James McCord
Journal: Journal of the American College of Cardiology (2019)
EFFICACY AND SAFETY OF TRANSCAROTID TRANSCATHETER AORTIC VALVE REPLACEMENT IN 495 PATIENTS: A SYSTEMATIC REVIEW
Authors: Tamunoinemi Bob-Manuel, Amit Nanda, Cynthia I. Anunobi, Jose Tafur Soto, James Jenkins, Uzoma Ibebuogu
Journal: Journal of the American College of Cardiology (2019)
ACCURACY AND REPRODUCIBILITY OF A NOVEL ARTIFICIAL INTELLIGENCE DEEP LEARNING-BASED ALGORITHM FOR AUTOMATED CALCULATION OF EJECTION FRACTION IN ECHOCARDIOGRAPHY
Authors: Federico M. Asch, Theodore Abraham, Madeline Jankowski, Jayne Cleve, Mike Adams, Nathanael Romano, Nicolas Polivert, Ha Hong, Roberto Lang
Journal: Journal of the American College of Cardiology (2019)
BURDEN OF ARRHYTHMIA IN SEPTIC PATIENTS FROM THE NATIONWIDE INPATIENT SAMPLE: 2005-2014
Authors: Harshil Shah, Mihir Dave, Hee Kong Fong, Safi Khan, Reena Motwani, Achint Patel, Muhammad Shahzeb Khan, Edo Kaluski
Journal: Journal of the American College of Cardiology (2019)
RISK STRATIFICATION USING THE HEART RATE RESPONSE TO REGADENOSON DURING MYCOARDIAL PERFUSION IMAGING IN TYPE 2 MYOCARDIAL INFARCTION
Authors: Chad Colon, Ramey Marshell, Christopher Roth, Ayman Farag, Ami Iskandrian, Fadi Hage
Journal: Journal of the American College of Cardiology (2019)
CLINICAL IMPORTANCE OF TROPONIN LEVEL IN 3,121 PATIENTS PRESENTING WITH ATRIAL FIBRILLATION (AF-TROP STUDY)
Authors: Amit Kaura, Ahran Arnold, Vasileios Panoulas, Benjamin Glampson, Jim Davies, Kerrie Woods, Abdulrahim Mulla, Joe Omigie, Anoop D. Shah, Keith Channon, Jonathan N. Weber, Mark R. Thursz, Paul Elliott, Harry Hemingway, Bryan Williams, Folkert W. Asselbergs, Rajesh Kharbanda, Graham M. Lord, Narbeh Melikian, Riyaz Patel, Divaka Perera, Ajay Shah, David Lefroy, Darrel Francis, Jamil Mayet
Journal: Journal of the American College of Cardiology (2019)
Abstract 18099: Emergency Department Trauma Patients Requiring Platelet Transfusions Display Early Platelet Dysfunction
Authors: Nathan J White, Lucas Ting, Alexander St. John, Xu Wang, Ari Karchin, Annie Smith, Nathan Sniadecki
Journal: Circulation (2017)

Introduction: Platelets contribute to hemostasis by rapidly sticking, aggregating, and contracting at wounds to stabilize blood clots. There is evidence that severe trauma with blood loss can render platelets dysfunctional, which is associated with increased mortality. However, this platelet dysfunction has not been well described. Hypothesis: We hypothesize that there is significant platelet dysfunction present in those trauma patients requiring urgent platelet transfusion for treatment of bleeding. Methods: We conducted a prospective observational trial of trauma patients presenting to a U.S. Level I trauma center. Subjects were enrolled and blood samples collected for blood chemistries, cell counts, coagulation, clot formation by rotational thromboelastometry (ROTEM), platelet aggregation after activation by thrombin, ADP, arachidonic acid, collagen, and ristocetin, and platelet contractile force by mechanical shear activation. Subject demographics, blood products transfused, and mortality were abstrac...
DIURNAL, SEASONAL, AND MONTHLY VARIATIONS IN OCCURRENCE OF VENTRICULAR ARRHYTHMIAS IN PATIENTS WITH IMPLANTABLE CARDIOVERTER DEFIBRILLATORS: INSIGHTS FROM A POOLED ANALYSIS
Authors: Abhishek Maan, Lou Sherfesee, Daniel Lexcen, Edwin Heist, Alan Cheng
Journal: Journal of the American College of Cardiology (2019)
Abstract 390: Mitochondrial ROS Drive Sudden Cardiac Death and Chronic Proteome Remodeling in Heart Failure
Authors: Swati Dey, Deeptankar DeMazumder, Brian O’Rourke
Journal: Circulation Research (2018)

Intro: Sudden cardiac death (SCD) from ventricular arrhythmias (VT/VF) claims more lives each year than all other disease-related causes of death combined. The underlying links between HF and SCD remain unclear. Reactive oxygen species (ROS) are central to SCD pathophysiology, but their effects depend on where and how ROS are generated. Employing innovative approaches, we hypothesized that mitochondrial ROS (mROS) is a principal source of oxidative stress in HF and in vivo reduction of mROS mitigates SCD. Methods: In a unique guinea pig model that mimics human non-ischemic HF with a high incidence of SCD, we performed a randomized 2x2 crossover study with MitoTEMPO therapy. We employed novel, genetically encoded ratiometric redox sensors for quantitative measurement of cytosol (cROS) or mROS of cardiomyocytes. Results: We show for the first time that mROS is elevated in failing hearts and that a mitochondrially targeted antioxidant (MitoTEMPO) normalizes cellular ROS, while NADPH oxidase inhibition is effective in correcting only the cROS component. in vivo mitoTEMPO treatment can prevent or reverse HF while eliminating SCD by decreasing T-wave dispersion and suppressing premature ventricular complexes (PVCs). Scavenging mROS suppressed chronic HF-induced remodeling of the expression proteome and prevented specific phosphoproteome alterations. Pathway analysis of mROS-sensitive networks indicated that, in HF, increased mROS disrupts the normal coupling between cytosolic signals and the nuclear gene programs driving mitochondrial function, antioxidant enzymes, Ca2+ handling and action potential repolarization. Conclusions: mROS drive both acute emergent events, such as electrical instability leading to SCD, and mediates chronic HF remodeling, characterized by suppression or altered phosphorylation of metabolic, antioxidant and ion transport protein networks. Impaired mROS scavenging cause failing hearts to become more vulnerable to demand-induced oxidative stress and promote arrhythmic SCD. Maintaining global redox balance by enhanced mROS scavenging may be an effective strategy for SCD therapy in HF.
NO EVIDENCE OF RURAL CARE DISPARITIES FOR ST-ELEVATION MYOCARDIAL INFARCTION WHEN MEASURED BY IN-HOSPITAL MORTALITY
Authors: Morgan Kellogg, Abigail R. Benkert, Yi-Ling Huang, Bina Ahmed, Todd MacKenzie, Matthew Watkins, Patrick Magnus, James Flynn, Peter VerLee, Lee Lucas, Sanjeev Francis, David Malenka
Journal: Journal of the American College of Cardiology (2019)
PROGNOSTIC ROLE OF TNM-LIKE CLASSIFICATION FOR HEART FAILURE AT 12 MONTHS OF FOLLOW-UP: COMPARISON WITH OTHERS NOSOLOGIES
Authors: Paolo Severino, Rossana Scarpati, Mariateresa Pucci, Maria Alfarano, Fabio Infusino, Sara Cimino, Simone Calcagno, Danilo Alunni Fegatelli, Viviana Maestrini, Annarita Vestri, Massimo Mancone
Journal: Journal of the American College of Cardiology (2019)
USE AND OUTCOMES OF DUAL CHAMBER AND CARDIAC RESYNCHRONIZATION THERAPY DEFIBRILLATORS AMONG OLDER PATIENTS UNDERGOING ICD IMPLANTATION WITH A VENTRICULAR PACING INDICATION: AN ANALYSIS OF THE NATIONAL CARDIOVASCULAR DATA ICD REGISTRY
Authors: Ryan T. Borne, Haikun Bao, Jeptha Curtis, Frederick Masoudi, Matthew Zipse, Amneet Sandhu, Jonathan Hsu, Pamela Peterson
Journal: Journal of the American College of Cardiology (2019)
Scott Gottlieb resigns as head of FDA
Authors: Janice Hopkins Tanne
Journal: BMJ (2019)

The commissioner of the US Food and Drug Administration, Scott Gottlieb, has unexpectedly resigned after serving less than two years in the post.

Gottlieb announced his intention to stand down in a letter to Alex Azar II, secretary of the Department of Health and Human Services, the FDA’s parent agency, on 5 March.

Gottlieb said that he would leave within a month, as he was tired of the long commute to see his wife and three young children, who live in Connecticut. His resignation was a surprise, as in January he had denied rumours that he was quitting.

No successor has been named. A new commissioner must be approved by the US Senate.

In his resignation letter Gottlieb praised his FDA colleagues and their achievements, including “major new policies to reduce the …
GERIATRIC ELEMENTS AND PRESCRIPTION OF WARFARIN VERSUS DIRECT ORAL ANTICOAGULANTS AMONG OLDER PATIENTS WITH AF: THE SAGE-AF STUDY
Authors: Summer Aldrugh, Saket Sanghai, Molly Waring, Catarina Kiefe, Robert Goldberg, Jerry Gurwitz, Darleen Lessard, David Parish, Robert Helm, Felix Sogade, Robert Hayward, Tanya Mailhot, Bruce Barton, Jane Saczynski, David McManus
Journal: Journal of the American College of Cardiology (2019)
Predicting and mapping human risk of exposure to Ixodes ricinus nymphs using climatic and environmental data, Denmark, Norway and Sweden, 2016
Authors: Lene Jung Kjær, Arnulf Soleng, Kristin Skarsfjord Edgar, Heidi Elisabeth H Lindstedt, Katrine Mørk Paulsen, Åshild Kristine Andreassen, Lars Korslund, Vivian Kjelland, Audun Slettan, Snorre Stuen, Petter Kjellander, Madeleine Christensson, Malin Teräväinen, Andreas Baum, Kirstine Klitgaard, René Bødker
Journal: Eurosurveillance (2019)

BackgroundTick-borne diseases have become increasingly common in recent decades and present a health problem in many parts of Europe. Control and prevention of these diseases require a better understanding of vector distribution.AimOur aim was to create a model able to predict the distribution of Ixodes ricinus nymphs in southern Scandinavia and to assess how this relates to risk of human exposure.MethodsWe measured the presence of I. ricinus tick nymphs at 159 stratified random lowland forest and meadow sites in Denmark, Norway and Sweden by dragging 400 m transects from August to September 2016, representing a total distance of 63.6 km. Using climate and remote sensing environmental data and boosted regression tree modelling, we predicted the overall spatial distribution of I. ricinus nymphs in Scandinavia. To assess the potential public health impact, we combined the predicted tick distribution with human density maps to determine the proportion of people at risk.ResultsOur model predicted the spatial distribution of I. ricinus nymphs with a sensitivity of 91% and a specificity of 60%. Temperature was one of the main drivers in the model followed by vegetation cover. Nymphs were restricted to only 17.5% of the modelled area but, respectively, 73.5%, 67.1% and 78.8% of the human populations lived within 5 km of these areas in Denmark, Norway and Sweden.ConclusionThe model suggests that increasing temperatures in the future may expand tick distribution geographically in northern Europe, but this may only affect a small additional proportion of the human population.
Graft-versus-MDS effect after unrelated cord blood transplantation: a retrospective analysis of 752 patients registered at the Japanese Data Center for Hematopoietic Cell Transplantation
Authors: Ken Ishiyama, Jun Aoki, Hidehiro Itonaga, Naoyuki Uchida, Satoshi Takahashi, Yuju Ohno, Yoshiko Matsuhashi, Toru Sakura, Makoto Onizuka, Shigesaburo Miyakoshi, Minoko Takanashi, Takahiro Fukuda, Yoshiko Atsuta, Shinji Nakao, Yasushi Miyazaki
Journal: Blood Cancer Journal (2019)

Abstract Allogeneic hematopoietic stem cell transplantation is the sole curative therapy for myelodysplastic syndrome (MDS). However, there is concern regarding graft failure and relapse in patients who undergo cord blood transplantation (CBT). We conducted a retrospective study of the CBT outcomes in MDS patients using the Japanese Data Center for Hematopoietic Cell Transplantation database. Seven hundred fifty-two de novo MDS patients of ≥18 years of age (median, 58 years) undergoing their first CBT between 2001 and 2015 were examined. Two-thirds of the patients were male, and were RAEB. The cumulative incidences of neutrophil and platelet engraftment at day 100 were 77 and 59%, respectively. The 3-year overall survival (OS) was 41% and the median survival of the patients was 1.25 years. A multivariate analysis of pre-transplant variables showed that the age, gender, cytogenetic subgroups, number of RBC transfusions, HCT-CI and year of CBT significantly influenced the outcome. The cumulative incidence of acute graft-versus-host disease (aGVHD) and chronic GVHD (cGVHD) was 32 and 21%, respectively. A survival benefit was observed in patients who developed cGVHD, but not aGVHD. Our results suggest that CBT is an acceptable alternative graft and that a graft-versus-MDS effect can be expected, especially in patients who develop cGVHD.
HEALTHCARE RESOURCE UTILIZATION ASSOCIATED WITH ELECTROCARDIOGRAPH (ECG) SENSOR PATCH SCREENING FOR ATRIAL FIBRILLATION (AF): RESULTS FROM THE MHEALTH SCREENING TO PREVENT STROKES (MSTOPS) TRIAL
Authors: Steven R. Steinhubl, Alison M. Edwards, Jill Waalen, Robert Zambon, Rajesh Mehta, Lauren Ariniello, Gail Ebner, Katie Baca-Motes, Chureen Carter, Elise Felicione, Troy Sarich, Eric Topol
Journal: Journal of the American College of Cardiology (2019)