tbuckley/cabot-search huggingface dataset:
Abstract 21158: Ultra-Short Caloric Restriction Prior to Cardiac Arrest and Resuscitation Leads to Improved Survival and Neurological Outcome in a Rodent Model
Authors: Matine Azadian, Afsheen Bazrafkan, Hamidreza Abbasi, Shuhab M Zaher, Juan Alcocer, Ramin Badiyan, Ieeshiah Otarola, Guilian Tian, Yama Akbari
Journal: Circulation (2017)

Introduction: Caloric restriction (CR) has been widely shown to have both cardioprotective and neuroprotective properties. However, nearly all studies have investigated chronic CR with mechanisms linked to the upregulation of SIRT-1 and BDNF. Minimal to no focus has been placed on the potential benefits of transient CR in models of brain injury, including stroke. Furthermore, the effects of transient CR in cardiac arrest-induced global cerebral ischemia have not been evaluated. We investigated the effects of overnight (~14-hour) CR on survival and neurological outcome in a rodent model of cardiac arrest (CA). Methods: Adult male Wistar rats (n=28) were divided into 75% CR (n=14) and non-CR (n=14) groups 14hrs prior to rats undergoing intubation, mechanical ventilation, cannulation of femoral vessels, and 8 minutes of asphyxial CA followed by cardiopulmonary resuscitation (CPR). Blood glucose was measured before CA. We conducted neurological deficit scale (NDS) behavioral testing at 4hrs, 24hrs, 48hrs, and 72hrs post-CA. The NDS score ranges from 0 (dead) to 80 (normal). Rats were euthanized after 72hrs and tissue was collected for protein analysis via Western blot. Results: CR, in comparison to no-CR, resulted in significant reduction of mortality (0% vs. 28.6%; Kaplan-Meier log-rank test, p&lt; 0.05). Of those that survived, NDS scores improved significantly in the CR group at 4hrs (32.8±6.1 vs. 24.5±3.3; p&lt;0.05), 24hrs (66.5±8.4 vs. 57.0±7.9; p&lt; 0.05), 48hrs (73.1±4.7 vs. 61.3±12.5; p&lt; 0.05), and 72hrs (76.3±3.3 vs. 73.14±12.2; p&lt; 0.05). CR also significantly lowered pre-CA glucose levels (151.0±22.1 vs. 220.7±17.5; p&lt; 0.05). Western blot analysis yielded no significant difference in BDNF and SIRT-1 expression in brain regions of CR vs. non-CR rats. Conclusions: Our results demonstrate that ultra-short CR (~14 hours) significantly improves survival and neurological outcome after CA/CPR. Interestingly, these improvements appear to be independent of BDNF or SIRT-1 pathways, commonly linked to chronic CR. While ultra-short CR improved glycemic control in rats, further investigation into the underlying molecular mechanisms are imperative to explore potential translational and therapeutic implications, including for patients at high risk of CA.
Tumour-infiltrating lymphocytes (TILs) in patients with epithelial ovarian cancer undergoing neoadjuvant chemotherapy: A retrospective study
Authors: S. Giovannoni, A. Garbi, G. Parma, M. Lapresa, E. Zaccarelli, A. Vingiani, I. Ardoino, G. Pruneri, N. Colombo
Journal: Annals of Oncology (2019)
Quality and Safety in Health Care, Part XLVI
Authors: Jay A. Harolds
Journal: Clinical Nuclear Medicine (2018)

Abstract Some of the approaches to prevent and recover from burnout focus on the individual, and others focus on organizational initiatives. A common recommendation for the individual with burnout is to practice meditation and mindfulness. Mindfulness may be defined as focused awareness without judgment regarding the current instance in time. The practice of mindfulness and the outcome of various mindfulness courses will be discussed in this article. Other approaches on the subject of burnout regarding individual efforts and organizational changes will be discussed in subsequent articles in this series.
Liquid biopsy assays using combined circulating tumour cells and circulating tumour DNA in the same patients for the diagnosis of primary lung cancer
Authors: Y. Suh, J.-S. Bae, H.S. Lee, J.-M. Moon, H.-J. Kwon, J. Kim, S.M. Moon, B.-H. Jeong, K. Lee, M.-S. Lee, B.H. Jeon, S. Lee, J.C. Park, S.-W. Um
Journal: Annals of Oncology (2019)
Characteristics and patterns of care of high-grade IDH-mutant gliomas in elderly patients: A French POLA network study
Authors: C. Montégut, J.-S. Guillamo, F. Ducray, C. Dehais, O. Chinot, E.L. Cohen-Jonathan Moyal, E. Le Rhun, H. Loiseau, R. Appay, D. Figarella-Branger, J.-Y. Delattre, E. Tabouret
Journal: Annals of Oncology (2019)
TRYbeCA-2: A randomized phase II/III study of eryaspase in combination with gemcitabine and carboplatin chemotherapy versus chemotherapy alone as first-line treatment in patients with metastatic or locally recurrent triple-negative breast cancer
Authors: A.H. Awada, J. Cortés, S. Slater, I. Macpherson, T. Csoszi, J.-B. Bertrand, A.-S. Clermont, R. Pollard, R. Chrestia-Blanchine, N. Biswas-Baldwin, H. Youssoufian, I. El-Hariry
Journal: Annals of Oncology (2019)
Outcomes, Toxicities, and Patterns of Use of Programmed Death-1 (PD-1) Inhibitors in Hodgkin Lymphoma Patients in the United States: A Multicenter Retrospective Study
Authors: Steven M. Bair, Lauren Elizabeth Strelec, Tatyana A Feldman, Nirav N Shah, Nishitha Reddy, Nadia Khan, Charalambos Andreadis, Chaitra S. Ujjani, Arun K Singavi, Christina Howlett, Khoan Vu, Malik Faheem, Matthew R. Youngman, Sunita Dwivedy Nasta, Daniel J. Landsburg, Anthony R. Mato, Stephen J. Schuster, Jakub Svoboda
Journal: Blood (2017)
TCT-274 Drug Eluting Stents versus Bare Metal Stents for Saphenous Vein Graft Interventions: A meta-analysis of randomized controlled trials.
Authors: Aakash Garg, Amit Rout, Abhishek Sharma, Gautam Visveswaran, Sunil Rao, Marc Cohen, Subhash Banerjee
Journal: Journal of the American College of Cardiology (2018)
An exoskeleton controlled by an epidural wireless brain–machine interface in a tetraplegic patient: a proof-of-concept demonstration
Authors: Alim Louis Benabid, Thomas Costecalde, Andrey Eliseyev, Guillaume Charvet, Alexandre Verney, Serpil Karakas, Michael Foerster, Aurélien Lambert, Boris Morinière, Neil Abroug, Marie-Caroline Schaeffer, Alexandre Moly, Fabien Sauter-Starace, David Ratel, Cecile Moro, Napoleon Torres-Martinez, Lilia Langar, Manuela Oddoux, Mircea Polosan, Stephane Pezzani, Vincent Auboiroux, Tetiana Aksenova, Corinne Mestais, Stephan Chabardes
Journal: The Lancet Neurology (2019)
Ramucirumab plus erlotinib in patients with untreated, EGFR-mutated, advanced non-small-cell lung cancer (RELAY): a randomised, double-blind, placebo-controlled, phase 3 trial
Authors: Kazuhiko Nakagawa, Edward B Garon, Takashi Seto, Makoto Nishio, Santiago Ponce Aix, Luis Paz-Ares, Chao-Hua Chiu, Keunchil Park, Silvia Novello, Ernest Nadal, Fumio Imamura, Kiyotaka Yoh, Jin-Yuan Shih, Kwok Hung Au, Denis Moro-Sibilot, Sotaro Enatsu, Annamaria Zimmermann, Bente Frimodt-Moller, Carla Visseren-Grul, Martin Reck, Quincy Chu, Alexis Cortot, Jean-Louis Pujol, Denis Moro-Sibilot, Elizabeth Fabre, Corinne Lamour, Helge Bischoff, Jens Kollmeier, Martin Reck, Martin Kimmich, Walburga Engel-Riedel, Stefan Hammerschmidt, Wolfgang Schütte, Konstantinos Syrigos, James Chung Man Ho, Kwok-Hung Au, Silvia Novello, Andrea Ardizzoni, Giulia Pasello, Vanessa Gregorc, Alessandro Del Conte, Domenico Galetta, Toshiaki Takahashi, Kazuhiko Nakagawa, Makoto Nishio, Kiyotaka Yoh, Takashi Seto, Fumio Imamura, Toru Kumagai, Katsuyuki Hotta, Yasushi Goto, Yukio Hosomi, Hiroshi Sakai, Yuichi Takiguchi, Young Hak Kim, Takayasu Kurata, Hiroyuki Yamaguchi, Haruko Daga, Isamu Okamoto, Miyako Satouchi, Satoshi Ikeda, Kazuo Kasahara, Shinji Atagi, Koichi Azuma, Toru Kumagai, Keisuke Aoe, Toru Kumagai, Keisuke Aoe, Yoshitsugu Horio, Nobuyuki Yamamoto, Hiroshi Tanaka, Satoshi Watanabe, Naoyuki Nogami, Tomohiro Ozaki, Ryo Koyama, Tomonori Hirashima, Hiroyasu Kaneda, Keisuke Tomii, Yuka Fujita, Masahiro Seike, Naoki Nishimura, Terufumi Kato, Masao Ichiki, Hideo Saka, Katsuya Hirano, Yasuharu Nakahara, Shunichi Sugawara, Keunchil Park, Sang-We Kim, Young Joo Min, Hyun Woo Lee, Jin-Hyoung Kang, Ho Jung An, Ki Hyeong Lee, Jin-Soo Kim, Gyeong-Won Lee, Sung Yong Lee, Aurelia Alexandru, Anghel Adrian Udrea, Óscar Juan-Vidal, Ernest Nadal-Alforja, Ignacio Gil-Bazo, Santiago Ponce-Aix, Luis Paz-Ares, Belén Rubio-Viqueira, Miriam Alonso Garcia, Enriqueta Felip Font, Jose Fuentes Pradera, Juan Coves Sarto, Meng-Chih Lin, Wu-Chou Su, Te-Chun Hsia, Gee-Chen Chang, Yu-Feng Wei, Chao-Hua Chiu, Jin-Yuan Shih, Jian Su, Irfan Cicin, Tuncay Goksel, Hakan Harputluoglu, Ozgur Ozyilkan, Ivo Henning, Sanjay Popat, Olivia Hatcher, Kathryn Mileham, Jared Acoba, Edward Garon, Gabriel Jung, Moses Raj, William Martin, Shaker Dakhil
Journal: The Lancet Oncology (2019)
Abstract P059: Utilizing Electronic Health Records to Evaluate Racial Disparities in Metabolic Syndrome
Authors: Denise Danos, Maura Kepper, Tekeda Ferguson, Claudia Leonardi, Richard Scribner
Journal: Circulation (2018)

Purpose: Metabolic syndrome is defined as a clustering of clinical metabolic conditions (increased blood pressure, high blood sugar, increased body fat, abnormal cholesterol or triglycerides) and has been associated with an increased risk for several chronic diseases, such as cardiovascular disease. The aim of this project was to identify individuals presenting with metabolic syndrome using a computational patient phenotype definition derived from electronic medical records (EHR) clinical outcomes data. Secondly, this project evaluated racial disparities in metabolic syndrome across Southeast Louisiana. Methods: Data was obtained through Research Action for Health Network (REACHnet). Using the National Patient-Centered Clinical Research Network Common Data Model, REACHnet has standardized and made usable EHR data for patient-centered research across Louisiana and Texas. The computational patient phenotype definition for metabolic syndrome was developed based on the National Cholesterol Education Program Expert Panel in Adult Treatment Panel III (NCEP III) guidelines. The presence of metabolic conditions was established using ICD9 Diagnosis codes, patient vitals and lab results that are routinely available in EHR data. Logistic regression models to assess racial disparities were executed using SAS 9.4. Results: We analyzed 18,664 patient EHRs for individuals 18 years or older with complete clinical data spanning the years 2013 to 2014. The sample was 43.28% male (n=8,077) and 29.35% black (n=5,477). Based on the patient phenotype definition, the prevalence of metabolic syndrome in the sample was 39.09%. Controlling for age, the odds of metabolic syndrome were twice as high for black women than for white women (OR= 2 (1.83, 2.18)), while the odds were 15% greater for black men than for white men (OR: 1.15 (1.04, 1.28)). Conclusion: We observed significant disparities in the prevalence of clinically evident metabolic syndrome in southeast Louisiana. Racial disparities were greatest among women. It has been increasingly recognized that differential exposure to chronic social and nutritive stress from living in a disadvantaged neighborhood may be contributing to racial health disparities. Further research in this sample will link ancillary sources of neighborhood data to the successfully developed metabolic syndrome phenotype to explore potential mechanisms for racial disparities in cardiovascular disease among a clinically-rich, state-wide sample.
Evaluating lung ct density changes among patients with extensive stage small cell lung cancer (ES-SCLC) treated with thoracic radiotherapy (TRT) alone or TRT followed by combined ipilimumab (IPI) and nivolumab (NIVO)
Authors: K. Latifi, S. Kim, T.J. Dilling, S.A. Rosenberg, J.E. Gray, S.J. Antonia, B. Perez
Journal: Annals of Oncology (2019)
Abstract 17941: Lipid Accumulation Product Can Identify Non-Alcoholic Fatty Liver Disease and Predict Stroke: The Kailuan Cohort Study
Authors: Shimin An, Yi-Da Tang
Journal: Circulation (2017)

Introduction: Non-alcoholic fatty liver disease (NAFLD) was known as a hepatic manifestation of metabolic syndrome and closely related to atherosclerosis. It is urgent to find a simple way to scree...
Proof of concept on the role of ex vivo lung cancer spheroids, cytokines expression and PBMCs profiling in monitoring disease history and response to treatments
Authors: R. Di Liello, V. Ciaramella, G. Barra, M. Fasano, F. Sparano, G. Viscardi, C.M. Della Corte, F. Ciardiello, F. Morgillo
Journal: Annals of Oncology (2019)
Circulating tumour DNA (ctDNA) analysis depicts mechanisms of resistance and tumour response to BRAF inhibitors in BRAF-mutant non-small cell lung cancer (NSCLC)
Authors: S. Ortiz - Cuaran, L. Mezquita, A. Swalduz, M. Aldea, J. Mazieres, C. Jovelet, L. Lacroix, A. Pradines, V. Avrillon, C. MahierAït Oukhatar, N. Hoog-Labouret, K. Howarth, J.-F. Guichou, C. Morris, E. Green, M. Perol, B. Besse, J.-Y. Blay, P. Saintigny, D. Planchard
Journal: Annals of Oncology (2019)
Anti-edema and antioxidant combination therapy for ischemic stroke via glyburide-loaded betulinic acid nanoparticles
Authors: Gang Deng, Chao Ma, Haitian Zhao, Shenqi Zhang, Jun Liu, Fuyao Liu, Zeming Chen, Ann T. Chen, Xin Yang, Jonathan Avery, Pan Zou, Fengyi Du, Keun-poong Lim, Daniel Holden, Songye Li, Richard E. Carson, Yiyun Huang, Qianxue Chen, W. Taylor Kimberly, J. Marc Simard, Kevin N. Sheth, Jiangbing Zhou
Journal: Theranostics (2019)

Stroke is a deadly disease without effective pharmacotherapies, which is due to two major reasons.First, most therapeutics cannot efficiently penetrate the brain.Second, single agent pharmacotherapy may be insufficient and effective treatment of stroke requires targeting multiple complementary targets.Here, we set to develop single component, multifunctional nanoparticles (NPs) for targeted delivery of glyburide to the brain for stroke treatment. Methods:To characterize the brain penetrability, we radiolabeled glyburide, intravenously administered it to strokebearing mice, and determined its accumulation in the brain using positron emission tomography-computed tomography (PET/CT).To identify functional nanomaterials to improve drug delivery to the brain, we developed a chemical extraction approach and tested it for isolation of nanomaterials from E. ulmoides, a medicinal herb.To assess the therapeutic benefits, we synthesized glyburide-loaded NPs and evaluated them in stroke-bearing mice. Results:We found that glyburide has a limited ability to penetrate the ischemic brain.We identified betulinic acid (BA) capable of forming NPs, which, after intravenous administration, efficiently penetrate the brain and significantly reduce ischemia-induced infarction as an antioxidant agent.We demonstrated that BA NPs enhance delivery of glyburide, leading to therapeutic benefits significantly greater than those achieved by either glyburide or BA NPs. Conclusion:This study suggests a new direction to identify functional nanomaterials and a simple approach to achieving anti-edema and antioxidant combination therapy.The resulting glyburide-loaded BA NPs may be translated into clinical applications to improve clinical management of stroke.
Epidemiology of seborrheic dermatitis
Authors: N. Zander, R. Sommer, I. Schäfer, R. Reinert, N. Kirsten, B.‐C. Zyriax, J.‐T. Maul, M. Augustin
Journal: British Journal of Dermatology (2019)

This study from research workers in Switzerland and Germany provides new information on the skin condition seborrheic dermatitis, more specifically how common it is and whether those with the condition have other diseases (co‐morbidities). Seborrhoeic dermatitis is a common disease which shows as redness, scaling and some irritation on areas of the head such as the eyebrows, around the nostrils, behind the ears and in the scalp. The work was based on voluntary skin health checks carried out in workplaces in Germany, involving more than 160,000 individuals. Seborrhoeic dermatitis was found in 4.6% of males and 1.4% of females and was commoner in those above the age of 35. Seborrhoeic dermatitis was commoner in those who had the following other skin conditions: folliculitis, fungal nail infections or tinea pedis (athlete's foot), rosacea, acne and psoriasis. The authors conclude that many of the other skin infections or conditions such as acne with which seborrheic dermatitis is associated, are those in which there are changes in the microbes (tiny organisms) in the skin (microbiome) and/or the production of fats or sebum on the skin surface.
Abstract MP36: Trends and Correlates of Physical Activity and Dietary Counseling for Adults With Cardiovascular Risk Factors: Medical Expenditure Panel Survey 2002-20015
Authors: Felipe Lobelo, Tianyi Zhuo, Jeniffer Frediani
Journal: Circulation (2019)

Background: In 2014 the United States Preventive Services Task Force (USPSTF) recommended offering overweight adults with additional cardiovascular disease (CVD) risk factors behavioral counseling to promote a healthful diet and physical activity (PA). Methods: Self-reported receipt of counseling, CVD risk (overweight/obesity, diabetes, smoking, high cholesterol and blood pressure) for adults were extracted from the Medical Expenditure Panel Survey (MEPS) household component (HC) 2002-2015. Prevalence rates for PA+diet counseling were calculated, adjusted by age, gender, insurance type, race/ethnicity, region, marital status, educational level, family income, number of health visits and CVD risk factors. To assess trends, we computed prevalence ratios (PR) at three time-points: 2002/03, 2009/10 and 2014/15, controlling for socio-demographics. Correlates of PA/diet counseling for 2014/15 were explored using adjusted PR. Results: The MEPS-HC response rate averaged 57.1% and included 116,048 observations across the 14-year period. The adjusted PA/diet counseling prevalence ranged from 43% to 63% (Figure 1). Compared to the 2002/03, PA+diet counseling increased in 2009/10 (PR=1.09 (1.07-1.12)). In 2014/15, compared to adults with private insurance, those with no insurance or Medicare reported lower PA+diet counseling (PR=0.91 (0.84-0.99); PR=0.77; (0.73-0.82), respectively). Females (PR=1.07 (1.03-1.11) and racial minorities reported higher PA+diet counseling (PR=1.31 (1.24-1.38); PR=1.11 (1.05-1.18); PR=1.12 (1.01-1.24), for Hispanic, Black and Asians, respectively). Compared to adults with 2 CVD risk factors, those with 3, 4 or 5 CVD risk factors reported higher PA+diet counseling (PR=1.46 (1.39-1.54); PR=1.74 (1.63-1.85); PR=1.89 (1.67-2.15), respectively). Conclusions: Modest increases in PA and diet counseling have occurred, primarily before ACA passing. However, half of eligible patients report not receiving counseling, particularly those with no insurance or Medicare.
Neoadjuvant Therapy Remodels the Pancreatic Cancer Microenvironment via Depletion of Protumorigenic Immune Cells
Authors: Carmen Mota Reyes, Steffen Teller, Alexander Muckenhuber, Björn Konukiewitz, Okan Safak, Wilko Weichert, Helmut Friess, Güralp O. Ceyhan, Ihsan Ekin Demir
Journal: Clinical Cancer Research (2019)

Abstract Purpose: Neoadjuvant therapy (neoTx) has dramatically improved the prognosis of patients with locally advanced and borderline resectable pancreatic ductal adenocarcinoma, yet its mechanisms of action on tumor cells and the tumor microenvironment are still unknown. Here, we aimed to characterize the multiple facets of neoTx-induced alterations in the pancreatic cancer microenvironment. Experimental Design: We performed the currently most comprehensive histopathologic analysis of desmoplasia, angiogenesis, neural invasion, and immune cell infiltration at the tumor–host interface of pancreatic cancer after neoTx (n = 37) versus after primary resection (n = 37) through quantitative IHC and double immunofluorescence using automated and software-based quantification algorithms. Results: We demonstrate that, independently of the applied pretreatment, neoadjuvant regimes are able to reverse the immunosuppressive behavior of malignant cells on pancreatic cancer microenvironment. Here, neoTx-driven selective depletion of regulatory T cells and myeloid-derived suppressor cells was associated with enrichment of antitumor immune cells in the peritumoral niche, decreased stromal activation, and less neural invasion. Importantly, the degree of this antitumor immune remodeling correlates to the degree of histopathologic response to neoTx. Survival analysis revealed that the tumor proliferation rate together with the activation of the stroma and the intratumoral infiltration with CD4+ T cells and natural killer cells constitute as independent prognostic factors for neoadjuvantly treated pancreatic cancer. Conclusions: NeoTx is not only cytotoxic but has pleiotropic, beneficial effects on all cellular and noncellular components of pancreatic cancer. Combinational approaches including immunotherapy may unleash long-term and more effective antitumor responses and improve prognosis of pancreatic cancer.
First report of efficacy and safety from a phase II trial of tislelizumab, an anti-PD-1 antibody, for the treatment of PD-L1+ locally advanced or metastatic urothelial carcinoma (UC) in Asian patients
Authors: D. Ye, J. Liu, A. Zhou, Q. Zou, H. Li, C. Fu, H. Hu, J. Huang, S. Zhu, J. Jin, L. Ma, J. Guo, J. Xiao, S.H. Park, D. Zhang, X. Qiu, Y. Bao, L. Zhang, W. Shen, B. Feng
Journal: Annals of Oncology (2019)
The biological implications of PDCD6 dysregulation in colorectal cancer
Authors: R. Briffa, J. Camps, I.H. Um, E. Asensio, S. Lahoz, S. Ariff, N. Refalo, J. DeGaetano, S. Mifsud, K. Grima, M. Hocking, G. Grech, D.J. Harrison
Journal: Annals of Oncology (2019)
Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome
Authors: C. Ronald Kahn, Guoxiao Wang, Kevin Y. Lee
Journal: Journal of Clinical Investigation (2019)

Over the past decade, great progress has been made in understanding the complexity of adipose tissue biology and its role in metabolism. This includes new insights into the multiple layers of adipose tissue heterogeneity, not only differences between white and brown adipocytes, but also differences in white adipose tissue at the depot level and even heterogeneity of white adipocytes within a single depot. These inter- and intra-depot differences in adipocytes are developmentally programmed and contribute to the wide range of effects observed in disorders with fat excess (overweight/obesity) or fat loss (lipodystrophy). Recent studies also highlight the underappreciated dynamic nature of adipose tissue, including potential to undergo rapid turnover and dedifferentiation and as a source of stem cells. Finally, we explore the rapidly expanding field of adipose tissue as an endocrine organ, and how adipose tissue communicates with other tissues to regulate systemic metabolism both centrally and peripherally through secretion of adipocyte-derived peptide hormones, inflammatory mediators, signaling lipids, and miRNAs packaged in exosomes. Together these attributes and complexities create a robust, multidimensional signaling network that is central to metabolic homeostasis.
Preliminary results from phase Ib study of spartalizumab plus chemotherapy for advanced non-small cell lung cancer (NSCLC)
Authors: A. Santoro, P. Garrido Lopez, D.S.W. Tan, L. Paz-Ares, F. Shepherd, A. Bearz, F. Barlesi, J.F. Vansteenkiste, T.M. Kim, T.R. Overbeck, I.I. Rybkin, E. Felip, W. Zhou, L. Santarpia, S. Eddy, E.S. Schaefer
Journal: Annals of Oncology (2019)
Identification of malnutrition risk factors in patients with cancer in the first nursing visit
Authors: A. Valverde, E. Uranga, G. Agirre, M. Murguiondo, G. Jauregui, J. San Francisco, I. Delgado, A. Barrio, L. Moreno, H. Telleria, L. Basterretxea
Journal: Annals of Oncology (2019)
Abstract 18410: Disruption of Beta-Catenin/VEGF/FLK-1/NADPH Oxidase Signaling Leads to Myocardial Ischemia Reperfusion Injury in Ischemic Preconditioned Myocardium: Study With GP91 Knockout Mice
Authors: Mahesh Thirunavukkarasu, Yuzo Akita, Ram Sudheer Adluri, Samson M Samuel, Bela Juhasz, Hajime Otani, Gautam Maulik, Nilanjana Maulik
Journal: Circulation (2010)

Ischemic preconditioning (IP) mediated activation of VEGF-FLK1-MKK2/NFkappaB pathway identifies these components as a critical regulator of myocardial angiogenesis in an infarcted myocardium. It is...