tbuckley/cabot-search huggingface dataset:
Taux de détection de polypes en fonction de l'âge: quand faut – il débuter le dépistage?
Authors: A Ben Mohamed, M Mahmoudi, L Hamzaoui, A Khsiba, M Medhioub, MM Azouz
Journal: Endoscopy (2019)

Bien que les sociétés savantes réservent leur programme de dépistage des patients à risque moyen de cancer colo-rectal (CCR) à la population comprise entre 50 à 75 ans, nous observons depuis quelques années que la néoplasie colorectale tend à toucher des sujets plus jeunes.
Bif-1 Interacts with Prohibitin-2 to Regulate Mitochondrial Inner Membrane during Cell Stress and Apoptosis
Authors: Sung-Gyu Cho, Xiao Xiao, Shixuan Wang, Hua Gao, Ruslan Rafikov, Stephen Black, Shang Huang, Han-Fei Ding, Yisang Yoon, Robert A. Kirken, Xiao-Ming Yin, Hong-Gang Wang, Zheng Dong
Journal: Journal of the American Society of Nephrology (2019)

Mitochondria are dynamic organelles that undergo fission and fusion. During cell stress, mitochondrial dynamics shift to fission, leading to mitochondrial fragmentation, membrane leakage, and apoptosis. Mitochondrial fragmentation requires the cleavage of both outer and inner membranes, but the mechanism of inner membrane cleavage is unclear. Bif-1 and prohibitin-2 may regulate mitochondrial dynamics.We used azide-induced ATP depletion to incite cell stress in mouse embryonic fibroblasts and renal proximal tubular cells, and renal ischemia-reperfusion to induce stress in mice. We also used knockout cells and mice to determine the role of Bif-1, and used multiple techniques to analyze the molecular interaction between Bif-1 and prohibitin-2.Upon cell stress, Bif-1 translocated to mitochondria to bind prohibitin-2, resulting in the disruption of prohibitin complex and proteolytic inactivation of the inner membrane fusion protein OPA1. Bif-1-deficiency inhibited prohibitin complex disruption, OPA1 proteolysis, mitochondrial fragmentation, and apoptosis. Domain deletion analysis indicated that Bif-1 interacted with prohibitin-2 via its C-terminus. Notably, mutation of Bif-1 at its C-terminal tryptophan-344 not only prevented Bif-1/prohibitin-2 interaction but also reduced prohibitin complex disruption, OPA1 proteolysis, mitochondrial fragmentation, and apoptosis, supporting a pathogenic role of Bif-1/prohibitin-2 interaction. In mice, Bif-1 bound prohibitin-2 during renal ischemia/reperfusion injury, and Bif-1-deficiency protected against OPA1 proteolysis, mitochondrial fragmentation, apoptosis and kidney injury.These findings suggest that during cell stress, Bif-1 regulates mitochondrial inner membrane by interacting with prohibitin-2 to disrupt prohibitin complexes and induce OPA1 proteolysis and inactivation.
How Gastrin-Releasing Peptide Opens the Spinal Gate for Itch
Authors: Martina Pagani, Gioele W. Albisetti, Nandhini Sivakumar, Hendrik Wildner, Mirko Santello, Helge C. Johannssen, Hanns Ulrich Zeilhofer
Journal: Neuron (2019)

Spinal transmission of pruritoceptive (itch) signals requires transneuronal signaling by gastrin-releasing peptide (GRP) produced by a subpopulation of dorsal horn excitatory interneurons. These neurons also express the glutamatergic marker vGluT2, raising the question of why glutamate alone is insufficient for spinal itch relay. Using optogenetics together with slice electrophysiology and mouse behavior, we demonstrate that baseline synaptic coupling between GRP and GRP receptor (GRPR) neurons is too weak for suprathreshold excitation. Only when we mimicked the endogenous firing of GRP neurons and stimulated them repetitively to fire bursts of action potentials did GRPR neurons depolarize progressively and become excitable by GRP neurons. GRPR but not glutamate receptor antagonism prevented this action. Provoking itch-like behavior by optogenetic activation of spinal GRP neurons required similar stimulation paradigms. These results establish a spinal gating mechanism for itch that requires sustained repetitive activity of presynaptic GRP neurons and postsynaptic GRP signaling to drive GRPR neuron output.
Need for Randomized Trials to Support Procedural Interventions
Authors: Sweekriti Sharma, Adrian C. Traeger, Ian Harris
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ELASTIC LIGATION OF INTERNAL HEMORRHOIDS: WHERE ARE WE NOW?!
Authors: R Benjira, H Abid, A Lamine Sejai, M Lahlali, N Lahmidani, M Elyousfi, DA Benajah, M Elabkari, A Ibrahimi
Journal: Endoscopy (2019)

Hemorrhoidal disease requires different means of treatment: medical, surgical and instrumental. Among these, the elastic ligature seems to be an effective and widespread technique in the world.
A prospective comparative study of sentinel lymph node biopsy with indo-cyanine green (ICG) florescence technique versus dual dye technique for early breast cancer: Going beyond the horizon
Authors: A. Kr, S. Sp, R. Kumar
Journal: Annals of Oncology (2019)

Background: The dual technique with radio colloid and blue dye is the gold standard in sentinel lymph node biopsy (SLNB) to stage axilla in breast cancer. The objective of the present study was to assess the diagnostic performance of sentinel lymph node (SLN) biopsy using the indocyanine green (ICG) fluorescence method compared with that using the conventional method in detection of sentinel lymph nodes. Methods: 60 patients diagnosed with early breast cancer underwent the SLNB procedure using technetium‐99m radio colloid (R), methylene blue dye (MB), and ICG. All SLNs that were removed during surgery were labelled as hot, blue or/and fluorescent and sent for pathological examination. The detection rate of SLNs and positive SLNs, and the number of SLNs of ICG, MB+ R, ICG + MB, ICG + R were compared. Injection safety of ICG and MB was evaluated. Results: Sentinel Lymph Node was identified in all 60 cases. Total Sentinel lymph nodes removed was 145 (Mean=2, Range 2-5), ICG was able to identify more nodes than the dual dye technique. The identification rate with the dual dye technique was 95%, with blue dye alone 93.6% and with radioisotope alone 96.8% whereas with ICG alone was 100%, with ICG + MB was 96.6% & ICG + R was 96.6 %. 28(46.6%) out of 60 patients had positive nodes which was identified by both dual dye & ICG. None of the patients had any local or systemic reaction with ICG, 3 patients with blue dye had tattooing & staining of skin. Conclusions: ICG is as effective as the dual dye for SLNB. In addition, as a near-infrared dye, it has the advantages of real-time visualization, lower cost, and wider availability, since no radioactive material needs to be handled. It can be a boon for developed countries & second tier centers of developing country where there is limited access to nuclear medicine department facility & the cost involved in its establishment. A combination of blue dye and ICG is useful dual approach when radioisotope is unavailable. Legal entity responsible for the study: Manipal Hospital. Funding: Has not received any funding. Disclosure: All authors have declared no conflicts of interest.
Longer Term Follow-up on the First Patients with Severe Hemoglobinopathies Treated with Lentiglobin Gene Therapy
Authors: Marina Cavazzana, Salima Hacein-Bey-Abina, Emmanuel Payen, Elisa Magrin, Alessandra Magnani, Michaela Semeraro, Laure Caccavelli, Fabien Touzot, Francois Lefrere, Felipe Suarez, Olivier Hermine, Valentine Brousse, Catherine Poirot, Despina Moshous, Philippe Bourget, Wassim El Nemer, Pablo Bartolucci, Leslie Weber, Herve Puy, Jean-François Meritet, David Grévent, Yves Beuzard, Stany Chretien, Thibaud Lefebvre, Mohammed Asmal, Alexandra Laura Miller, Mariane De Montalembert, Stephane Blanche, Philippe Leboulch, Jean-Antoine Ribeil
Journal: Blood (2017)
Endoscopic closure of a 6-cm long esophageal defect with tracheoesophageal fistula
Authors: Danny Issa, Qais Dawod, Marwan Azzam, Kartik Sampath, David Carr-Locke, Reem Z. Sharaiha
Journal: Endoscopy (2019)

A 68-year-old man with metastatic esophageal adenocarcinoma previously treated with esophagectomy and chemoradiation presented with new-onset dysphagia and cough. A recent good response to chemotherapy resulted in shrinkage of a 7-cm mediastinal metastasis. Chest computed tomography revealed a large esophageal defect. A barium swallow confirmed the presence of a tracheoesophageal fistula (TEF). Upper endoscopy showed a 6-cm defect on the anterior esophageal wall with a clear opening into the trachea ([Fig. 1], [Video 1]).
CLINICAL SIGNIFICANCE OF REGIONAL LYMPH NODE ENLARGEMENT IN PATIENTS WITH EGC WITHIN THE EXPANDED CRITERIA FOR ESD
Authors: SY Choi, JK Park, DS Lee, SJ Lee
Journal: Endoscopy (2019)

Lymph node (LN) metastasis is negligible in early gastric cancer (EGC) within expanded criteria for endoscopic submucosal dissection (ESD). However, regional lymph nodes in abdominal CT scans are sometimes enlarged in patients with EGC within the expanded criteria for endoscopic submucosal dissection (ESD). In this study, we investigated the clinical significance of regional lymph node enlargement on abdominal CT scan in patients with EGC within the expanded criteria for ESD.
Circulating levels of the components of the GH/IGF-1/IGFBPs axis total and intact IGF-binding proteins (IGFBP) 3 and IGFBP 4 and total IGFBP 5, as well as PAPPA, PAPPA2 and Stanniocalcin-2 levels are not altered in response to energy deprivation and/or metreleptin administration in humans
Authors: Eleni Pilitsi, Natia Peradze, Nikolaos Perakakis, Christos S. Mantzoros
Journal: Metabolism (2019)
Multi-layer surface modification of pancreatic islets for magnetic resonance imaging using ferumoxytol
Authors: Sang-Man Jin, Han Sin Lee, Muhammad R. Haque, Hun Nyun Kim, Hyun Jin Kim, Bae Jun Oh, Kyo Won Lee, Gyuri Kim, Hyung Shik Kim, Dong Yun Lee, Jae Berm Park, Sung Joo Kim, Youngro Byun, Jae Hyeon Kim
Journal: Biomaterials (2019)
Evaluation des valeurs de produit dose surface délivrés lors des examens endoscopiques sous contrôle radiologique
Authors: C Lefort, B Napoléon, R Gincul, F Fumex, V Lepilliez
Journal: Endoscopy (2019)

L'optimisation des doses délivrées pendant les examens endoscopiques sous contrôle radiologique permet de réduire les doses recues par le patient et le personnel exposé. Les référentiels sont actuellement peu nombreux et souvent anciens, souvent antérieurs aux recommandations publiées pour diminuer les doses délivrées. L'objectif principal de ce travail est d'évaluer les valeurs de notre centre, les comparer aux référentiels existants, et proposer une réévaluation après application des mesures apprises lors de la formation à la radioprotection (juin 2018).
CAN WE USE POLYP DETECTION RATE (PDR) ALONE TO DESCRIBE ADEQUATE INSPECTION OF BOWEL MUCOSA?
Authors: G Vojtěchová, O Ngo, B Buckova, T Grega, M Voska, O Majek, M Zavoral, S Suchanek
Journal: Endoscopy (2019)

The aim of our study was to assess whether polyp detection rate (PDR) correlates with adenoma detection rate (ADR) and with mean adenoma per colonoscopy (APC). Our effort was to determine minimal marginal value for APC.
RELIABILITY AND ACCURACY OF BLUE LIGHT IMAGING FOR STAGING OF INTESTINAL METAPLASIA IN STOMACH (BLIMPS)
Authors: R Castro, D Libânio, C Santos, LP Afonso, P Pimentel-Nunes, M Dinis-Ribeiro
Journal: Endoscopy (2019)

A grading endoscopic system using high-resolution scopes with NBI has been shown to accurately identify patients with extensive GIM (EGGIM) that need surveillance. However, no description is available with alternative systems such as the new system of Fujifilm, BLI. We aim to determine the reliability and accuracy of BLI regarding the diagnosis and staging of GIM.
DIAGNOSTIC YIELD OF ENDOSCOPY FOR PREDICTION OF ACUTE GRAFT VERSUS HOST DISEASE IN THE UPPER GASTROINTESTINAL TRACT
Authors: L Schulze, A Kreft, K Mönkemüller, PR Galle, H Neumann
Journal: Endoscopy (2019)

Intestinal graft-versus-host disease (GvHD) is a frequent complication after hematopoietic progenitor cell transplantation (HSCT) and biopsies are recommended for diagnosis. However, the best biopsy sites have yet not been clearly established and final histology results are often delayed as specific staining is required.
Abstract 12600: Treatment and Outcomes by LDL-C Level in Statin-Naive Non-ST-Elevation Myocardial Infarction (NSTEMI) Patients: Findings From the CRUSADE Registry
Authors: Emily C O'Brien, Dajuanicia N Holmes, Matthew T Roe, Eric D Peterson, Karen S Alexander
Journal: Circulation (2013)

Background: Elevated low-density lipoprotein cholesterol (LDL-C) is associated with increased risk of myocardial infarction and is a target for disease prevention. The association between initial L...
The negative pressure therapy with PICO as a prevention of surgical site infection in high risk patients undergoing breast surgery
Authors: T. Fogacci, F. Cattin, D. Samorani
Journal: Annals of Oncology (2019)

Background: The negative pressure therapy (NPWT) is usually used to treat difficult and chronic wounds. Among NPWT devices, some of them, like PICO, have a proven utility as a prophylaxis against surgical wound complications in high risk patients. PICO is a fixed intensity instrument, working with a continuous -80mmHg pressure over the wound. Methods: In the MARIPI study 100 high risk patients have been enrolled, 50 of them received a PICO plaster directly in the surgical room. We have then evaluated the difference in incidence of surgical wound complications between the case and control groups.Patients have been considered eligible to our study in the period 01.01.2016 to 01.01.2017 due to one or more of these following risk factors: diabetes, heavy smoke (more than 10 cigarettes per day), previous radiotherapy in the thoracic fields, skin diseases, vascular or cardiac alterations. Results: After a deep results analysis, significant difference in the wound infection rate comes out: 1(4.3% ) in the PICO group vs 3 (13,0%) in control group. The same consideration can be made concerning the wound dehiscences: 2 (8.7%) in the PICO group, 6 in the control one (26,1%). (p = 0.093) The whole number of patients' clinical checks was 113 in the PICO group and 150 in the control one (p < 0.001) Medications with negative pressure reduce the wound infection rate down to about 50 and the dehiscence rate of about 66%, and this can lead to a costs reduction even considering the cost of 200$ (about 130 €) for any PICO medication. Conclusions: In our opinion, similarly to what may be found in the literature concerning other kinds of surgery, the use of PICO for risk reduction is justified in high risk patients. Further and broader randomized studies are in any case needed to better clarify the role of the therapies with negative pressure in breast cancer patients. Legal entity responsible for the study: AUSL Romagna. Funding: Has not received any funding. Disclosure: All authors have declared no conflicts of interest.
Mitochondria‐Targeted Two‐Photon Fluorescent Photosensitizers for Cancer Cell Apoptosis via Spatial Selectability
Authors: Yun Ni, Hang Zhang, Chou Chai, Bo Peng, Ang Zhao, Jie Zhang, Lin Li, Chengwu Zhang, Bo Ma, Hua Bai, Kah‐Leong Lim, Wei Huang
Journal: Advanced Healthcare Materials (2019)

Abstract Organelle‐targeted photosensitizers have been reported to be effective cell apoptosis agents. Mitochondria is recognized as an ideal target for cancer treatment due to its central role in oxidative metabolism and apoptosis. Meanwhile, two‐photon (TP) fluorescence microscopy has become a powerful tool for fluorescence imaging in biological events based on its minimizing photodamage/photobleaching and intrinsic 3D resolution in deep tissues and in vivo. In this study, a series of novel mitochondrial‐targeted TP fluorescent photosensitizers (TP‐tracers) are designed, synthesized, and systematically investigated. These TP‐tracers exhibit extraordinary anti‐interference capability among different cations, anions, and amino acids as well as the insensitivity to the changes of pH and complex biological environments. TP‐tracers are further used in fluorescence living cells, Drosophila brains, and zebrafish imaging with low cytotoxicity, excellent mitochondria‐targeting, and TP properties. The results demonstrate efficient mitochondria‐targeting cell selective apoptosis based on TP‐activated cancer cells with highly single cell selectivity, and the pharmacokinetic study reveals that MitoY2 does not have accumulation in rats. It is believed that these molecules hold great potential in TP‐related smart phototherapy.
Dangers of Opioid Prescribing for Young Adults After Dental Procedures
Authors: Elliot V. Hersh, Mana Saraghi, Paul A. Moore
Journal: JAMA Internal Medicine (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Glycated Hemoglobin A1c Levels in Type 1 Diabetes Mellitus and Outcomes After Myocardial Infarction
Authors: Thomas Nyström, Ulrik Sartipy, Andrea Contardi, Marcus Lind, Rino Bellocco, Björn Eliasson, Ann-Marie Svensson, Martin J. Holzmann
Journal: Circulation (2019)
Correction: Adolescent idiopathic scoliosis
Authors: Jack C. Cheng, René M. Castelein, Winnie C. Chu, Aina J. Danielsson, Matthew B. Dobbs, Theodoros B. Grivas, Christina A. Gurnett, Keith D. Luk, Alain Moreau, Peter O. Newton, Ian A. Stokes, Stuart L. Weinstein, R. Geoffrey Burwell
Journal: Nature Reviews Disease Primers (2015)
Multi-gene panel testing at the hereditary breast and ovarian cancer (HBOC) unit of the Hospital Clinic of Barcelona
Authors: B. Adamo, L. Moreno, L. Gaba, M. Vidal, T. Pascual, N. Chic, I. Alonso, J.A. Puig-Butillé, M. Muñoz, A. Prat
Journal: Annals of Oncology (2019)

Background: The variety and clinical characteristics of BRCA1/2 and non-BRCA1/2 mutations in women with a suspicion of HBOC before the implementation of multi-gene panels in our referral population was unknown. Methods: This is an exploratory study of all consecutive women tested at the HBOC Unit between 2016-2018. TruSight Cancer panel (Illumina) was used and 16 genes were analyzed: BRCA1, BRCA2, PALB2, ATM, CDH1, CHEK2, TP53, NBN, PTEN, STK11, BRIP1, MLH1, MSH2, MSH6, RAD51D and RAD51C. The main objective was to determine the prevalence of pathogenic mutations (PM) and variants of uncertain significance (VUS). Other secondary objectives were explored such as the distribution of the breast cancer (BC) subtypes and the pathological complete response (pCR) rates following neoadjuvant anthracycline/taxane-based chemotherapy in BRCA1/BRCA2/PALB2-PM BC. Results: 451 women were tested. PM and a VUS were found in 60 (12.7%) and 42 (8.9%) patients, respectively. Among PM cases, 37 (62%) had BC and 23 (38%) had OC. The PMs identified in BC were BRCA2 (35.1%), BRCA1 (21.6%), PALB2 (24.3%), TP53 (8.1%), ATM (5.4%), BRIP1 (2.7%) and PTEN (2.7%). All women with PALB2 PM had BC. Within BRCA2-PM BC, the most common subtype was Luminal B (54%), followed by triple-negative (23%), Luminal A (15%) and HER2-positive (8%). Within cases with BRCA1-PM BC, the most common subtype was triple-negative (88%) followed by Luminal B (12%). Within cases with PALB2-PM BC, the most common subtype was Luminal B (56%), followed triple-negative (33%) and Luminal A (11%). Interestingly, within patients BRCA1/BRCA2/PALB2-PM BC (n = 30), only 1 (3.3%) case had HER2+ BC. Following neoadjuvant chemotherapy, 11 of 17 (58%) cases with BRCA1/BRCA2/PALB2-PM BC achieved a pCR. Within cases with OC, PM identified were BRCA2 (39.1%), BRCA1 (39.1%), TP53 (4.3%), BRIP1 (4.3%), CHEK2 (4.3%), RAD51D (4.3%) and MSH6 (4.3%). Conclusions: Our in-house clinical guidelines detect >10% of tested cases with HBOC. Non-BRCA1/2 PM are found in 35% of the cases. BRCA1/BRCA2/PALB2-PM BC is associated with aggressive tumor biology and high chemotherapy sensitivity. Legal entity responsible for the study: Hospital Clinic of Barcelona. Funding: Has not received any funding. Disclosure: A. Prat: Advisory role/lecture fees: NanoString Technologies, Roche, Pfizer, MSD, Novartis, Lilly; Funding: NanoString Technologies, Novartis; Scientific advisory role: Oncolytics Biotech. All other authors have declared no conflicts of interest.
Prescription exemption rules are “overly complex” and cause genuine mistakes, says watchdog
Authors: Elisabeth Mahase
Journal: BMJ (2019)

Rules on prescription exemptions set by the Department of Health and Social Care are too complicated, causing patients to make genuine mistakes, the National Audit Office has said.1

The spending watchdog investigated penalty charge notices (PCNs) issued to patients who claim free prescriptions or dental treatment fraudulently or in error, and it found a significant increase in exemption checks and the fines issued.

In February The BMJ reported that the number of PCNs issued to patients in England had risen by a third last year and by 60% in the past three …
DO CIRRHOTIC PATIENTS HAVE HIGHER RISK OF COMPLICATION FOLLOWING ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY? A SINGLE CENTER STUDY
Authors: KH Kim, BI Jang, JH Cho, SB Kim, KO Kim, SH Lee, TN Kim
Journal: Endoscopy (2019)

Endoscopic retrograde cholangiopancreatography (ERCP) is one of the most important procedures in the diagnosis and treatment of pancreaticobiliary disease. However, there is still insufficient data on the complication rate of ERCP in patients with liver cirrhosis (LC). The aim of this study was to investigate the rate of complications following ERCP in cirrhotic patients.