tbuckley/cabot-search huggingface dataset:
Covid-19 vaccine trial protocols released
Authors: Peter Doshi
Journal: BMJ (2020)

<h3>Abstract</h3> We aimed to characterize the relationship of the oral microbiome with diabetes in Pakistan. Saliva samples were collected from diabetic patients (n = 49) and healthy individuals (n = 55). 16S metagenomics saliva was carried out by NGS technology. We observed that the phylum Firmicutes (p-value = 0.024 at 95% confidence interval) was significantly more abundant among diabetic patients than among the controls. We found that the abundance of phylum Actinobacteria did not significantly vary among both groups in contrast to a similar report from the USA (Long et al., 2017). On genus level, acidogenic bacteria <i>Prevotella</i> (p-value = 0.024) and <i>Leptotrichia</i> (p-value = 1.5 × 10<sup>−3</sup>); and aciduric bacteria <i>Veillonella</i> (p-value = 0.013) were found to be in higher abundance in diabetic patients. These bacteria are found in dental biofilm and involved in the metabolism of fermentable carbohydrates. Stratified analysis by gender revealed healthy and diabetic females to be more divergent. Abundance of <i>Prevotella</i> (p-value = 4.4 × 10-3) and <i>Leptotrichia</i> (p-value = 0.015) was significantly associated with male patients. A comparison of oral bacteriome between two groups revealed the dominance of acidogenic and aciduric bacteria in diabetics which suggested the involvement of these eubacteria in oral dysbacteriosis in diabetes mellitus.
Coinfection with HCV or HBV Increases the Risk of Lymphoma in HIV-Positive Patients: A Combined Analysis of the Lymphovir-ANRS-CO16 and Fhdh-ANRS-CO4 Cohorts
Authors: Caroline Besson, Nicolas Noel, Remi Lancar, Sophie Prevot, Michele Algarte-Genin, Rosenthal Eric, Fabrice Bonnet, Marie-Caroline Meyohas, Marialuisa Partisani, Lucie Oberic, Jean Gabarre, Cecile Goujard, Antoine Cheret, Cedric Arvieux, Bertrand Coiffier, Christine Katlama, Dominique Salmon, Francois Boue, Regis T. Costello, Nawel Mekerri, Houria Hendel-Chavez, Yassine Taoufik, Helene Fontaine, Paul Coppo, Nicolas Mounier, Pierre Delobel, Dominique Costagliola
Journal: Blood (2017)
Modeling COVID-19 scenarios for the United States
Authors: Robert C. Reiner, Ryan M. Barber, James K. Collins, Peng Zheng, Christopher Adolph, James Albright, Catherine M. Antony, Aleksandr Y. Aravkin, Steven D. Bachmeier, Bree Bang-Jensen, Marlena S. Bannick, Sabina Bloom, Austin Carter, Emma Castro, Kate Causey, Suman Chakrabarti, Fiona J. Charlson, Rebecca M. Cogen, Emily Combs, Xiaochen Dai, William James Dangel, Lucas Earl, Samuel B. Ewald, Maha Ezalarab, Alize J. Ferrari, Abraham Flaxman, Joseph Jon Frostad, Nancy Fullman, Emmanuela Gakidou, John Gallagher, Scott D. Glenn, Erik A. Goosmann, Jiawei He, Nathaniel J. Henry, Erin N. Hulland, Benjamin Hurst, Casey Johanns, Parkes J. Kendrick, Apurva Khemani, Samantha Leigh Larson, Alice Lazzar-Atwood, Kate E. LeGrand, Haley Lescinsky, Akiaja Lindstrom, Emily Linebarger, Rafael Lozano, Rui Ma, Johan Månsson, Beatrice Magistro, Ana M. Mantilla Herrera, Laurie B. Marczak, Molly K. Miller-Petrie, Ali H. Mokdad, Julia Deryn Morgan, Paulami Naik, Christopher M. Odell, James K. O’Halloran, Aaron E. Osgood-Zimmerman, Samuel M. Ostroff, Maja Pasovic, Louise Penberthy, Geoffrey Phipps, David M. Pigott, Ian Pollock, Rebecca E. Ramshaw, Sofia Boston Redford, Grace Reinke, Sam Rolfe, Damian Francesco Santomauro, John R. Shackleton, David H. Shaw, Brittney S. Sheena, Aleksei Sholokhov, Reed J. D. Sorensen, Gianna Sparks, Emma Elizabeth Spurlock, Michelle L. Subart, Ruri Syailendrawati, Anna E. Torre, Christopher E. Troeger, Theo Vos, Alexandrea Watson, Stefanie Watson, Kirsten E. Wiens, Lauren Woyczynski, Liming Xu, Jize Zhang, Simon I. Hay, Stephen S. Lim, Christopher J. L. Murray
Journal: Nature Medicine (2020)

Abstract We use COVID-19 case and mortality data from 1 February 2020 to 21 September 2020 and a deterministic SEIR (susceptible, exposed, infectious and recovered) compartmental framework to model possible trajectories of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and the effects of non-pharmaceutical interventions in the United States at the state level from 22 September 2020 through 28 February 2021. Using this SEIR model, and projections of critical driving covariates (pneumonia seasonality, mobility, testing rates and mask use per capita), we assessed scenarios of social distancing mandates and levels of mask use. Projections of current non-pharmaceutical intervention strategies by state—with social distancing mandates reinstated when a threshold of 8 deaths per million population is exceeded (reference scenario)—suggest that, cumulatively, 511,373 (469,578–578,347) lives could be lost to COVID-19 across the United States by 28 February 2021. We find that achieving universal mask use (95% mask use in public) could be sufficient to ameliorate the worst effects of epidemic resurgences in many states. Universal mask use could save an additional 129,574 (85,284–170,867) lives from September 22, 2020 through the end of February 2021, or an additional 95,814 (60,731–133,077) lives assuming a lesser adoption of mask wearing (85%), when compared to the reference scenario.
TCT CONNECT-465 Implantation Characteristics and Development of Hypoattenuated Leaflet Thickening in Low Risk Patients Undergoing Transcatheter Aortic Valve Replacement
Authors: Jaffar Khan, Toby Rogers, Gaby Weissman, Chava Chezar-Azerrad, Federico Asch, Ron Waksman
Journal: Journal of the American College of Cardiology (2020)
TCT CONNECT-342 Outcomes of MitraClip Repair in Primary Mitral Regurgitation Patients With STS Repair Score of Less Than 6% and STS Replacement Score of Less Than 8%: Results From the Global EXPAND Study
Authors: Gilbert Tang, Mathew Williams, Michael Rinaldi, Paolo Denti, Annapoorna Kini, Stamatios Lerakis, Andrew Morse, Evelio Rodriguez, Francesco Maisano, Saibal Kar
Journal: Journal of the American College of Cardiology (2020)
Antimicrobial susceptibility of Neisseria gonorrhoeae in Barcelona during a five-year period, 2013 to 2017
Authors: Paula Salmerón, Belén Viñado, Rachid El Ouazzani, Marta Hernández, María Jesús Barbera, Mireia Alberny, Mireia Jané, Nieves Larrosa, Tomás Pumarola, Yannick Hoyos-Mallecot, Judit Serra-Pladevall
Journal: Eurosurveillance (2020)

Introduction Increasing rates of antimicrobial resistance in Neisseria gonorrhoeae cause problems for treating gonorrhoea. Aim This observational study aimed to describe isolates from all patients found infected with N. gonorrhoeae , in Barcelona, Spain, between 2013 and 2017, and with available antimicrobial susceptibility data. Methods Minimum inhibitory concentrations (MICs) of penicillin (PEN), cefixime (CFM), ceftriaxone (CRO), azithromycin (AZM), ciprofloxacin (CIP), spectinomycin (SPT), fosfomycin (FOF) and gentamicin (GEN) were determined by E-test. Susceptibility was assessed using clinical breakpoints from the European Committee on Antimicrobial Susceptibility Testing. Time trends for PEN, CFM, AZM and CIP were investigated using logistic regression. Results Of 1,979 patients with infection (2,036 isolates), 1,888 (95.4%) were men. Patient median age was 32 years. The proportions of isolates resistant to extended-spectrum cephalosporins were low, with 0.3% (5/1,982) resistant to CRO and 4.9% (98/1,985) to CFM. AZM resistance prevalence was 2.7% (52/1,981), including 16 isolates detected in 2016 and 2017, with high-level resistance. For CIP, 51.3% (1,018/1,986) of isolates were resistant, and for PEN, 20.1% (399/1,985). All isolates were susceptible to SPT. MIC 50 and MIC 90 values of GEN were 4 and 6 mg/L and of FOF 12 and 24 mg/L, respectively. Between 2013 and 2017, PEN and CFM resistance rates each decreased from 28.1% (92/327) to 12.2% (70/572) and from 8.3% (27/327) to 4.4% (25/572) (p ≤ 0.0073). In contrast, AZM resistance prevalence appeared to increase from 1.5% in 2014 (5/340) to 3.0% (17/572) in 2017. No trend was identified for CIP. Conclusion Antimicrobial susceptibility surveillance is important to timely detect new phenotypes and trends.
Reply to Mezidi <i>et al.</i>: Assessment of Airway Closure and Expiratory Airflow Limitation to Set Positive End-Expiratory Pressure in Morbidly Obese Patients with Acute Respiratory Distress Syndrome
Authors: Aditi Balakrishna, Raffaele Di Fenza, Caio C. A. Morais, David A. Imber, Pankaj Arora, Robert M. Kacmarek, Roberta De Santis Santiago, Lorenzo Berra
Journal: American Journal of Respiratory and Critical Care Medicine (2020)
Abstract 18297: Transvenous Lead Extraction in Patients With Venous Stenosis is Associated With Increased Risk of Vascular Injury - An Analysis of the Nationwide Inpatient Sample
Authors: Vivek Yarlagadda, Justin Z Lee, Arun Sridhar, Komandoor Srivathsan, Siva Mulpuru
Journal: Circulation (2017)

Introduction: Venous stenosis is a recognized complication following the implantation of an ICD or a pacemaker. Venous obstruction of ipsilateral access vein poses some technical challenges during ...
TCT CONNECT-64 Impact of DAPT Cessation in High Bleeding-Risk Patients Undergoing PCI: Insights From the PARIS Registry
Authors: Davide Cao, George Dangas, Samantha Sartori, Zhongjie Zhang, Cono Ariti, Mauro Chiarito, Johny Nicolas, Rishi Chandiramani, Ridhima Goel, Anastasios Roumeliotis, Matteo Nardin, Bimmer Claessen, David Cohen, Timothy Henry, C. Michael Gibson, Mitchell Krucoff, David Moliterno, Antonio Colombo, Giora Weisz, Bernhard Witzenbichler, Annapoorna Kini, Philippe Steg, Stuart Pocock, Roxana Mehran
Journal: Journal of the American College of Cardiology (2020)
Preschool wheeze: Challenges and research prospects reply to: Dr Jartti and Colleagues; in response to our manuscript entitled: Medical algorithm: Diagnosis and treatment of preschool asthma
Authors: Andrew Bush, Sejal Saglani
Journal: Allergy (2020)

To The Editor, We thank Dr Jartti and colleagues1 for their interest in our manuscript.2 We agree that the INFANT study3 conclusions on blood eosinophil count were post hoc and require prospective validation. We also agree that rhinovirus (RV)-triggered attacks have a high predictive value for school-age asthma.4 Whether such patients benefit from conventional asthma medication, including prednisolone, is still controversial; no acute benefit of prednisolone is seen in preschool wheeze,5 and early use of inhaled steroids in preschool wheeze does not prevent progression to asthma. Admittedly, most studies do not discriminate by viral infection, but given that RV infection is so common, it is surprising that no signal has been seen in big studies if any of these medications were beneficial. Nonetheless, a large prospective randomized trial of management after first acute RV wheeze episode is certainly indicated. However, viral diagnostics for every child with preschool wheeze would prove expensive in the clinical setting, making it important to consider the relevance and clinical application of tests to detect specific viral organisms during attacks. We certainly agree that there is a need to prevent asthma developing, and indeed that is a major focus of our research,6 but we were tasked to write mainly about acute management of preschool wheeze, with a limited word count. Dr Saglani has nothing to disclose. Dr Bush has nothing to disclose.
Identification of recently identified tick-borne viruses (Dabieshan tick virus and SFTSV) by metagenomic analysis in ticks from Shandong Province, China
Authors: Lijun Shao, Zheng Pang, Hongchen Fu, Ruiheng Chang, Zuomiao Lin, Aiqun Lv, Shenghan Wang, Xiangbing Kong, Meihui Luo, Xing Liu, Xiaoli Yu, Lin Liu, Guoyu Niu
Journal: Journal of Infection (2020)
TCT CONNECT-197 Outcomes of Percutaneous and Surgical Pulmonary Valve Implantation
Authors: Michael Megaly, Kelly Han, Ramy Sedhom, Jamil Aboulhosn, Francis Moga, Karol Mudy, Ayman Elbadawi, Wassim Mosleh, Santiago Garcia
Journal: Journal of the American College of Cardiology (2020)
COVID-19 Mortality Risk in Down Syndrome: Results From a Cohort Study of 8 Million Adults
Authors: Ashley Kieran Clift, Carol A.C. Coupland, Ruth H. Keogh, Harry Hemingway, Julia Hippisley-Cox
Journal: Annals of Internal Medicine (2020)

Background: At the start of the coronavirus disease 2019 (COVID-19) pandemic, many national health organizations emphasized nonpharmacologic interventions, such as quarantining or physical distancing.In the United Kingdom, strict self-isolation ("shielding") was advised for those deemed to be clinically extremely vulnerable on the basis of the presence of selected medical conditions or at the discretion of their general practitioners.Down syndrome features on neither the U.K. shielding list nor the U.S. Centers for Disease Control and Prevention list of groups at "increased risk."However, it is associated with immune dysfunction, congenital heart disease, and pulmonary pathology and, given its prevalence, may be a relevant albeit unconfirmed risk factor for severe .Objective: To evaluate Down syndrome as a risk factor for death from COVID-19 through a comprehensive analysis of individual-level data in a cohort study of 8.26 million adults (aged >19 years), as part of a wider COVID-19 risk prediction project commissioned by the U.K. government (2).Methods and Findings: We used QResearch, a populationlevel primary care database that has collected data for more
TCT CONNECT-250 Comparison of Thromboresistance of Everolimus-Eluting Fluoropolymer Stents and Competitive Drug-Eluting Stents Between Aspirin and Clopidogrel Single Antiplatelet Therapy Using an Ex Vivo Swine Shunt Model and Evaluation of a Novel Flow Loop Model Under Aspirin Single Antiplatelet Therapy
Authors: Yu Sato, Hiroyuki Jinnouchi, Frank Kolodgie, Qi Cheng, Christine Janifer, Atsushi Sakamoto, Anne Cornelissen, Rika Kawakami, Masayuki Mori, Kenji Kawai, Laura Perkins, Renu Virmani, Aloke Finn
Journal: Journal of the American College of Cardiology (2020)
Hospitalizations for Chronic Disease and Acute Conditions in the Time of COVID-19
Authors: Saul Blecker, Simon A. Jones, Christopher M. Petrilli, Andrew J. Admon, Himali Weerahandi, Fritz Francois, Leora I. Horwitz
Journal: JAMA Internal Medicine (2020)

Hriday P. Bhambhvani, BS; Adrian J. Rodrigues, BA; Jonathan S. Yu, BS; James B. Carr II, MD; Melanie Hayden Gephart, MD, MAS
Valley Fever (Coccidioidomycosis) Awareness — California, 2016–2017
Authors: Glorietta Hurd-Kundeti, Gail L. Sondermeyer Cooksey, Seema Jain, Duc J. Vugia
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

Valley fever (coccidioidomycosis) is endemic in the southwestern United States and caused by inhalation of Coccidioides spp. fungal spores from soil or dust; 97% of U.S. Valley fever cases are reported from Arizona and California (1). In California, Valley fever incidence increased 213% from 2014 to 2018 (2). In 2016, the California Department of Public Health (CDPH) added three questions to the adult California Behavioral Risk Factor Surveillance System (BRFSS) survey to better understand whether Californians had heard of Valley fever, knew the environmental risk where they live, and knew who is at risk for severe disease. A total of 2,893 BRFSS respondents aged ≥18 years answered at least one Valley fever question. Using the weighted California population, 42.4% of respondents reported general awareness of Valley fever; awareness was lowest among adults aged 18-44 years (32.9%) and Hispanic persons (26.4%). In addition, despite higher percentages reporting awareness of Valley fever, only 25.0% of persons living in a high-incidence region and 3.0% of persons living in a moderate-incidence region were aware that they lived in areas where Coccidioides spp. exist. Among persons with one or more risk factors for severe disease, 50.8% reported having heard about Valley fever, but only 3.5% knew they were at increased risk for severe disease. The findings from this survey helped to inform a statewide Valley fever awareness campaign implemented during 2019-2020 and to guide outreach to persons living in high- and moderate-incidence regions in California and potentially other southwestern states or who are at risk for severe disease.
TCT CONNECT-36 Relook Coronary Angiography Following Successful Primary Percutaneous Coronary Intervention
Authors: Mehmet Yildiz, Christian Schmidt, Santiago Garcia, Ross Garberich, Larissa Stanberry, Scott Sharkey, Frank Aguirre, Mark Tannenbaum, Daniel Shivapour, Roberto Pacheco-Coronado, Timothy Smith, Jenny Chambers, Heather Rohm, Teresa Coulson, Timothy Henry
Journal: Journal of the American College of Cardiology (2020)
Polysocial Risk Scores for Assessing Social Determinants of Health
Authors: Stuart A. Kinner, Rohan Borschmann
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tuberculosis, human rights, and law reform: Addressing the lack of progress in the global tuberculosis response
Authors: Matthew M. Kavanagh, Lawrence O. Gostin, John Stephens
Journal: PLoS Medicine (2020)

Tuberculosis (TB) remains the world's leading infectious killer with 10 million annual cases and only limited progress in recent years when it comes to reducing new cases.Progress is hampered by continuing gaps in detection and treatment.• With evidence that TB programs are hampered by the legal environment, we analyze the degree to which law reform is needed to align with promises at the United National High Level Meeting on Tuberculosis to promote human rights and dignity in the TB response.
Abstract IA24: Navigating the new normal: Trends shaping post-COVID-19 cancer care delivery
Authors: Lisa Richardson
Journal: Clinical Cancer Research (2020)

In just a few short weeks, COVID-19 transformed cancer care around the world. The crisis has dismantled how care is delivered and forced providers to make difficult decisions about what types of care are essential and can be sustained with the resources and staff available. This presentation will provide an overview of the emerging trends that are shaping cancer care and how providers are adapting to these new challenges to continue to safely provide necessary care to those who need it most.Citation Format: Lisa Richardson. Navigating the new normal: Trends shaping post-COVID-19 cancer care delivery [abstract]. In: Proceedings of the AACR Virtual Meeting: COVID-19 and Cancer; 2020 Jul 20-22. Philadelphia (PA): AACR; Clin Cancer Res 2020;26(18_Suppl):Abstract nr IA24.
Adrenergic Ca <sub>V</sub> 1.2 Activation via Rad Phosphorylation Converges at α <sub>1C</sub> I-II Loop
Authors: Arianne Papa, Jared Kushner, Jessica A. Hennessey, Alexander N. Katchman, Sergey I. Zakharov, Bi-xing Chen, Lin Yang, Ree Lu, Stephen Leong, Johanna Diaz, Guoxia Liu, Daniel Roybal, Xianghai Liao, Pedro J. del Rivero Morfin, Henry M. Colecraft, Geoffrey S. Pitt, Oliver Clarke, Veli Topkara, Manu Ben-Johny, Steven O. Marx
Journal: Circulation Research (2020)

Rationale: Changing activity of cardiac Ca V 1.2 channels under basal conditions, during sympathetic activation, and in heart failure is a major determinant of cardiac physiology and pathophysiology. Although cardiac Ca V 1.2 channels are prominently upregulated via activation of PKA (protein kinase A), essential molecular details remained stubbornly enigmatic. Objective: The primary goal of this study was to determine how various factors converging at the Ca V 1.2 I-II loop interact to regulate channel activity under basal conditions, during β-adrenergic stimulation, and in heart failure. Methods and Results: We generated transgenic mice with expression of Ca V 1.2 α 1C subunits with (1) mutations ablating interaction between α 1C and β-subunits, (2) flexibility-inducing polyglycine substitutions in the I-II loop (GGG-α 1C ), or (3) introduction of the alternatively spliced 25-amino acid exon 9* mimicking a splice variant of α 1C upregulated in the hypertrophied heart. Introducing 3 glycine residues that disrupt a rigid IS6–α-interaction domain helix markedly reduced basal open probability despite intact binding of Ca V β to α 1C I-II loop and eliminated β-adrenergic agonist stimulation of Ca V 1.2 current. In contrast, introduction of the exon 9* splice variant in the α 1C I-II loop, which is increased in ventricles of patients with end-stage heart failure, increased basal open probability but did not attenuate stimulatory response to β-adrenergic agonists when reconstituted heterologously with β 2B and Rad or transgenically expressed in cardiomyocytes. Conclusions: Ca 2+ channel activity is dynamically modulated under basal conditions, during β-adrenergic stimulation, and in heart failure by mechanisms converging at the α 1C I-II loop. Ca V β binding to α 1C stabilizes an increased channel open probability gating mode by a mechanism that requires an intact rigid linker between the β-subunit binding site in the I-II loop and the channel pore. Release of Rad-mediated inhibition of Ca 2+ channel activity by β-adrenergic agonists/PKA also requires this rigid linker and β-binding to α 1C .
Making ordinary decisions in extraordinary times: a response
Authors: J F Cosgrove, Simon Conroy, Christopher Bassford, Katherine Henderson, Liza Keating, Zoe Fritz, Jugdeeb Deshi, Steven Jones, Deborah Thompson, Alistair Gilmore
Journal: BMJ (2020)

With respect to the first wave of the covid-19 pandemic, Burman and colleagues question the extent of decision support guidance.1 While we agree that government guidance was lacking, clinically developed guidelines for decision making surrounding admission to intensive care were developed and disseminated. In September 2019, before the pandemic, the Faculty of Intensive Care Medicine published guidance on decision making, advance care planning, and end-of-life care.2 This included a …