tbuckley/cabot-search huggingface dataset:
Association of Routine Infant Vaccinations With Antibody Levels Among Preterm Infants
Authors: Elsbeth D. M. Rouers, Patricia C. J. Bruijning-Verhagen, Pieter G. M. van Gageldonk, Josephine A. P. van Dongen, Elisabeth A. M. Sanders, Guy A. M. Berbers
Journal: JAMA (2020)

The standard schedule of national immunization programs for infants may not be sufficient to protect extremely and very preterm infants.To evaluate the immunogenicity of routine vaccinations administered to preterm infants.A multicenter, prospective, observational cohort study of preterm infants stratified according to gestational age recruited from 8 hospitals across the Netherlands between October 2015 and October 2017, with follow-up until 12 months of age (October 2018). In total, 296 premature infants were enrolled and compared with a control group of 66 healthy term infants from a 2011 study, immunized according to the same schedule with the same vaccines.Three primary doses of the diphtheria-tetanus toxoids-acellular pertussis-inactivated poliomyelitis-Haemophilus influenza type b-hepatitis B combination vaccine were given at 2, 3, and 4 months after birth followed by a booster at 11 months and a 10-valent pneumococcal conjugate vaccine at 2, 4, and 11 months after birth.Primary end points were (1) proportion of preterm infants who achieved IgG antibody against vaccine antigens at concentrations above the internationally defined threshold for protection after the primary series and booster dose and (2) serum IgG geometric mean concentrations after the primary series and booster vaccination. Proportions and geometric mean concentrations were compared in preterm infants and the control group of term infants.Of 296 preterm infants (56.1% male; mean gestational age, 30 weeks), complete samples before vaccination, 1 month after the primary series, and 1 month after the booster were obtained from 220 preterm infants (74.3%). After the primary series, the proportion of preterm infants across all gestational age groups who achieved protective IgG antibody levels against pertussis toxin, diphtheria, tetanus and 6 of 10 pneumococcal serotypes varied between 83.0% and 100%, Haemophilus influenzae type b between 34.7% and 46.2% (40.6% among all preterm infants overall), and pneumococcal serotypes 4, 6B, 18C, and 23F between 45.8% and 75.1%. After the booster dose, protective antibody levels were achieved in more than 95% of all preterm groups, except for Haemophilus influenzae type b (88.1%). In general, geometric mean concentrations of all vaccine-induced antibodies were significantly lower in all preterm infants vs term infants, except for pertussis toxin and pneumococcal serotypes 4 and 19F after the primary series and booster vaccination.Among preterm infants, administration of routine vaccinations during the first year of life was associated with protective antibody levels against most antigens in the majority of infants after the primary series and booster, except for Haemophilus influenzae type b. However, antibody concentrations were generally lower among preterm infants compared with historical controls.
Oscillometry: old physiology with a bright future
Authors: Peter M.A. Calverley, Ramon Farré
Journal: European Respiratory Journal (2020)

Taking an ancient notion from Roman and Medieval authors [1], Isaac Newton wrote to Robert Hooke: 'if I have seen further, it is by standing on the shoulders of giants' [2]. This reasoning feels particularly true in the field of respiratory physiology. In 1956, Arthur DuBois helped describe a new method of measuring the lung volume of a person in a sealed chamber by measuring the pressure changes at the mouth and within the container [3]. Body plethysmography was born and is now used across the world in the diagnosis and management of many respiratory conditions. In the same year, DuBois and colleagues analysed the mechanical properties of the respiratory system during tidal breathing when an oscillating pressure was applied at high frequencies [4], and in 1968, Grimby and colleagues suggested that airway resistance in patients with obstructive lung diseases depends on the oscillation frequency [5]. This respiratory mechanics approach, which we reviewed in a previous editorial [6], is now called oscillometry, although many will know it better as the forced oscillation technique. It is much less well known than plethysmography and has been slower to make its way into clinical practice. Why is this? Oscillometry is an old physiologically based technique that has recently been shown to be potentially useful for patient monitoring and personalised treatment. <https://bit.ly/3e4j8aA>
SARS-CoV-2–Associated Deaths Among Persons Aged &lt;21 Years — United States, February 12–July 31, 2020
Authors: Danae Bixler, Allison D. Miller, Claire P. Mattison, Burnestine Taylor, Kenneth Komatsu, Xandy Peterson Pompa, Steve Moon, Ellora Karmarkar, Caterina Y. Liu, John J. Openshaw, Rosalyn E. Plotzker, Hilary E. Rosen, Nisha Alden, Breanna Kawasaki, Alan Siniscalchi, Andrea Leapley, Cherie Drenzek, Melissa Tobin-D'Angelo, Judy Kauerauf, Heather Reid, Eric Hawkins, Kelly White, Farah Ahmed, Julie Hand, Gillian Richardson, Theresa Sokol, Seth Eckel, Jim Collins, Stacy Holzbauer, Leslie Kollmann, Linnea Larson, Elizabeth Schiffman, Theresa S. Kittle, Kimberly Hertin, Vit Kraushaar, Devin Raman, Victoria LeGarde, Lindsey Kinsinger, Melissa Peek-Bullock, Jenna Lifshitz, Mojisola Ojo, Robert J Arciuolo, Alexander Davidson, Mary Huynh, Maura K. Lash, Julia Latash, Ellen H. Lee, Lan Li, Emily McGibbon, Natasha McIntosh-Beckles, Renee Pouchet, Jyotsna S. Ramachandran, Kathleen H. Reilly, Elizabeth Dufort, Wendy Pulver, Ariela Zamcheck, Erica Wilson, Sietske de Fijter, Ozair Naqvi, Kumar Nalluswami, Kirsten Waller, Linda J. Bell, Anna-Kathryn Burch, Rachel Radcliffe, Michelle D. Fiscus, Adele Lewis, Jonathan Kolsin, Stephen Pont, Andrea Salinas, Kelsey Sanders, Bree Barbeau, Sandy Althomsons, Sukhshant Atti, Jessica S. Brown, Arthur Chang, Kevin R. Clarke, S. Deblina Datta, John Iskander, Brooke Leitgeb, Talia Pindyck, Lalita Priyamvada, Sarah Reagan-Steiner, Nigel A. Scott, Laura J. Viens, Jonathan Zhong, Emilia H. Koumans, David Blythe, Laurel Harduar Morano, Carla Black, Carter McCabe, Xia Lin
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

US Department of Health and Human Services/Centers for Disease Control and Prevention to mask wearing, physical distancing, hand hygiene).To ensure accurate surveillance, it is important that health care providers and health departments assure follow-up for infants, children, adolescents, and young adults infected with or exposed to SARS-CoV-2 and document and report underlying medical conditions and cause of death related to COVID-19.Health departments, in collaboration with school districts and the communities they serve, can evaluate and improve health promotion, health access, and health equity for all infants, children, adolescents, and young adults.Ultimately, health departments, health providers, and community partners can mobilize to remove systemic barriers that contribute to health disparities.
Effects of vitamin D on mood and sleep in the healthy population: Interpretations from the serotonergic pathway
Authors: Laura M. Huiberts, Karin C.H.J. Smolders
Journal: Sleep Medicine Reviews (2020)

Vitamin D insufficiency is common in the healthy population. Recent insights addressed the role of vitamin D in serotonin and melatonin regulation, suggesting that increasing vitamin D status may be helpful for improving mood and sleep. This literature review covers the current state of evidence regarding potential effects of vitamin D on mood and sleep indicators in healthy people. In total, 11 observational studies were found for sleep, and 54 studies on mood (including ten RCTs). These studies revealed mixed results for both sleep and mood. The findings were interpreted based on the previously proposed serotonergic pathway of vitamin D. Implications and challenges for future research regarding the timing of blood sampling, timing and dosage of supplement intake and investigating the response dynamics are discussed.
Randomized Trial of Nocturnal Oxygen in Chronic Obstructive Pulmonary Disease
Authors: Yves Lacasse, Frédéric Sériès, François Corbeil, Marc Baltzan, Bruno Paradis, Paula Simão, Araceli Abad Fernández, Cristóbal Esteban, Miguel Guimarães, Jean Bourbeau, Shawn D. Aaron, Sarah Bernard, François Maltais
Journal: New England Journal of Medicine (2020)

Long-term oxygen therapy improves survival in patients with chronic obstructive pulmonary disease (COPD) and chronic severe daytime hypoxemia. However, the efficacy of oxygen therapy for the management of isolated nocturnal hypoxemia is uncertain.We designed this double-blind, placebo-controlled, randomized trial to determine, in patients with COPD who have nocturnal arterial oxygen desaturation without qualifying for long-term oxygen therapy, whether nocturnal oxygen provided for a period of 3 to 4 years would decrease mortality or the worsening of disease such that patients meet current specifications for long-term oxygen therapy. Patients with an oxygen saturation of less than 90% for at least 30% of the recording time on nocturnal oximetry were assigned, in a 1:1 ratio, to receive either nocturnal oxygen or ambient air from a sham concentrator (placebo). The primary outcome was a composite of death from any cause or a requirement for long-term oxygen therapy as defined by the Nocturnal Oxygen Therapy Trial (NOTT) criteria in the intention-to-treat population.Recruitment was stopped prematurely because of recruitment and retention difficulties after 243 patients, of a projected 600, had undergone randomization at 28 centers. At 3 years of follow-up, 39.0% of the patients assigned to nocturnal oxygen (48 of 123) and 42.0% of those assigned to placebo (50 of 119) met the NOTT-defined criteria for long-term oxygen therapy or had died (difference, -3.0 percentage points; 95% confidence interval, -15.1 to 9.1).Our underpowered trial provides no indication that nocturnal oxygen has a positive or negative effect on survival or progression to long-term oxygen therapy in patients with COPD. (Funded by the Canadian Institutes of Health Research; INOX ClinicalTrials.gov number, NCT01044628.).
A Report of Toxin‐Induced Graft Injury Following Liver Transplantation for Yellow Phosphorus Poisoning
Authors: Sandeep Jasper, Abdul Rahman Hakeem, Mukul Vij, Deepti Sachan, Akila Rajakumar, Dinesh Jothimani, Ilankumaran Kaliamoorthy, Mettu Srinivas Reddy, Mohamed Rela
Journal: Hepatology (2020)

Jasper, Sandeep; Hakeem, Abdul Rahman; Vij, Mukul; Sachan, Deepti; Rajakumar, Akila; Jothimani, Dinesh; Kaliamoorthy, Ilankumaran; Reddy, Mettu Srinivas; Rela, Mohamed Author Information
Real-World Evaluation of Factors for Interstitial Lung Disease Incidence and Radiologic Characteristics in Patients With EGFR T790M–positive NSCLC Treated With Osimertinib in Japan
Authors: Akihiko Gemma, Masahiko Kusumoto, Fumikazu Sakai, Masahiro Endo, Terufumi Kato, Yoshinobu Saito, Tomohisa Baba, Masafumi Sata, Ou Yamaguchi, Yutaka Yabuki, Yuhiko Nogi, Masahisa Jinushi, Kei Sakamoto, Masatoshi Sugeno, Reiko Tamura, Toshimitsu Tokimoto, Yuichiro Ohe
Journal: Journal of Thoracic Oncology (2020)

IntroductionUsing real-world Japanese postmarketing data, we characterized interstitial lung disease (ILD) development during the second- or later-line osimertinib treatment for EGFR mutation-positive NSCLC. Retrospective radiologic image evaluation of patients developing ILD was also performed.MethodsPatients who had ILD events reported as an adverse drug reaction by their physicians and who were assessed as having developed ILD as assessed by an ILD expert committee in Japan were included.ResultsAmong 3578 patients, 252 ILD events were reported in 245 patients (6.8%) by their attending physicians. The median (range) time to the first onset of ILD after osimertinib treatment initiation was 63.0 (5–410) days, and 29 patients with a fatal outcome were reported. The ILD expert committee assessed 231 of 3578 patients (6.5%) as having ILD. A previous history of nivolumab therapy (adjusted OR: 2.84; 95% confidence interval: 1.98–4.07) and a history or concurrence of ILD (3.51; 2.10–5.87) were identified as factors potentially associated with ILD onset during osimertinib treatment. In patients who had received a previous nivolumab treatment, the number and proportion of patients developing ILD were highest for patients who discontinued nivolumab treatment within the first month before initiating osimertinib; trends for decreasing incidence and proportion were observed, with an increasing duration between the end of nivolumab treatment and the initiation of osimertinib treatment.ConclusionsThe frequency of ILD was consistent with the known osimertinib safety profile in the Japanese population. A history or concurrence of ILD and history of previous nivolumab therapy are factors potentially associated with ILD onset during osimertinib treatment.
Preoperative Medical Testing and Falls in Medicare Beneficiaries Awaiting Cataract Surgery
Authors: Catherine L. Chen, Stephen D. McLeod, Thomas M. Lietman, Hui Shen, W. John Boscardin, Han-Ying Peggy Chang, Mary A. Whooley, Adrian W. Gelb, Sei J. Lee, R. Adams Dudley
Journal: Ophthalmology (2020)
Safety and immunogenicity of co-administered hookworm vaccine candidates Na-GST-1 and Na-APR-1 in Gabonese adults: a randomised, controlled, double-blind, phase 1 dose-escalation trial
Authors: Ayola A Adegnika, Sophia G de Vries, Frejus J Zinsou, Yabo J Honkepehedji, Jean-Claude Dejon Agobé, Kafui G Vodonou, Rodrigue Bikangui, Aurore Bouyoukou Hounkpatin, Emmanuel B Bache, Marguerite Massinga Loembe, Remko van Leeuwen, Marjan Molemans, Peter G Kremsner, Maria Yazdanbakhsh, Peter J Hotez, Maria Elena Bottazzi, Guangzhao Li, Jeffrey M Bethony, David J Diemert, Martin P Grobusch, Yoanne D Mouwenda, Eunice Betouke Ongwe, Anne-Marie Nkoma Mouima, Odilon P Nouatin, Jean R Edoa, Prince G Manouana, Susana Pinto de Jesus, Vera Kühne, Benjamin Mordmueller, Bertrand Lell, Selidji T Agnandji, Carsten Koehler
Journal: The Lancet Infectious Diseases (2020)
Genotypic and Phenotypic Analysis of 34 Cases of Inherited Junctional Epidermolysis Bullosa caused by COL17A1 Mutations
Authors: A. Charlesworth, A.L. Hérissé, N. Bellon, S. Leclerc-Mercier, E. Bourrat, S. Hadj-Rabia, C Bodemer, J.P. Lacour, C. Chiaverini
Journal: British Journal of Dermatology (2020)

Inherited epidermolysis bullosa defines a heterogeneous group of genodermatoses characterized by skin and/or mucosa fragility resulting in blistering. The junctional variant (JEB) is associated with mutations affecting the genes expressing the components of the dermo-epidermal junction (DEJ) [1-2]. We report 34 JEB patients with COL17A1 genetic mutations diagnosed in our Center between 1993 and 2019. Medical and biological records were collected with a standardized questionnaire.
How mental health care is changing in Cameroon because of the COVID-19 pandemic
Authors: Justine Laure Menguene Mviena, Mahamat Fanne, Rumbidzai Gondo, Ambele Judith Mwamelo, Linda Esso, Emilienne Epée, Georges Alain Etoundi Mballa, Yap Boum
Journal: The Lancet Psychiatry (2020)
Recurrent Gene Mutations and Clinical Outcome in the Context of Lenalidomide Treatment of Relapsed/Refractory CLL — Results from Multicenter Phase II Trial CLL-009
Authors: Veronika Opatrna, Eugen Tausch, Graeme Fraser, Anne-Sophie Michallet, Peter Hillmen, Jan Dürig, Matt Kalaycio, John G. Gribben, Thomas J. Kipps, Brendan Purse, Jennie Zhang, Sabine De Bedout, Asher A. Chanan-Khan, Michael J. Hallek, Clemens-Martin Wendtner, Hartmut Döhner, Stephan Stilgenbauer
Journal: Blood (2017)
Abstract 18712: Adeno-associated Viral Gene Delivery of Calsequestrin 2 Protects Adult Calsequestrin 2-R33Q Knock-in Mice From Developing Ventricular Tachycardias
Authors: Marco Denegri, José E Avelino-Cruz, Veronica C De Giusti, Francesco Lodola, Antonio Curcio, Rossana Bongianino, Valentina Leccioli, Simona Boncompagni, Feliciano Protasi, Alberto Auricchio, Carlo Napolitano, Silvia G Priori
Journal: Circulation (2012)

Background. Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) is a highly lethal recessive arrhythmogenic disease associated with mutations in the calsequestrin 2 (CASQ2) gene. We previously demonstrated that CASQ2 gene delivery was able to rescue the arrhythmic phenotype in CASQ2 knock-out (KO) mice 5 months after the viral infection. The aim of the present study is to investigate the long-term effects of viral gene delivery in CASQ2-R33Q missense mutation mouse model. Methods. Newborn CPVT mice were infected with adeno-associated viral vector 9 (AAV9) containing the coding sequence of the wild type CASQ2 co-expressed with green fluorescent protein (GFP) gene. Furthermore, we evaluated the effect at 7 and 12 months after viral infection by in vivo ECG analysis, in vitro electrophysiological and molecular assays. Results. Telemeter recording of ECG demonstrated in vivo ventricular tachycardias (VT) after epinephrine (2 mg/Kg) administration in only 17% (2 out of 12) of the infected mice, while ...
Reply to Vincenzo Ficarra, Giuseppe Mucciardi, and Gianluca Giannarini’s Letter to the Editor re: Riccardo Campi, Daniele Amparore, Umberto Capitanio, et al. Assessing the Burden of Nondeferrable Major Uro-oncologic Surgery to Guide Prioritisation Strategies During the COVID-19 Pandemic: Insights from Three Italian High-volume Referral Centres. Eur Urol2020;78:11–15
Authors: Riccardo Campi, Daniele Amparore, Umberto Capitanio, Enrico Checcucci, Andrea Salonia, Cristian Fiori, Andrea Minervini, Alberto Briganti, Marco Carini, Francesco Montorsi, Sergio Serni, Francesco Porpiglia
Journal: European Urology (2020)
Good perioperative care can cut post-surgery complications by up to 80%, review shows
Authors: Adrian O’Dowd
Journal: BMJ (2020)

Patients who receive good perioperative care can have fewer complications after surgery, shorter hospital stays, and quicker recovery times, shows a large review of research.1

The Centre for Perioperative Care, a partnership between the Royal College of Anaesthetists, other medical and nursing royal colleges, and NHS England, reviewed 27 382 articles published between 2000 and 2020 to understand the evidence about perioperative care, eventually focusing on 348 suitable studies.

An estimated 10 million or so people have surgery in the NHS in the UK each year, with elective surgery costing £16bn a year.

Good perioperative care—the integrated …
Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes
Authors: Bruce Neal, Vlado Perkovic, David R Matthews
Journal: New England Journal of Medicine (2017)

up to 10 times as high as that of summary scoring. 3 We suggest that the authors reanalyze their data using psychometric methods, such as Rasch analysis, that are based on item-response theory; such methods significantly reduce measurement noise and produce interval-level measurement.
Gene Therapy of the Hemoglobinopathies
Authors: Joachim B. Kunz, Andreas E. Kulozik
Journal: HemaSphere (2020)

Abstract Sickle cell disease and the ß‐thalassemias are caused by mutations of the ß‐globin gene and represent the most frequent single gene disorders worldwide. Even in European countries with a previous low frequency of these conditions the prevalence has substantially increased following large scale migration from Africa and the Middle East to Europe. The hemoglobin diseases severely limit both, life expectancy and quality of life and require either life‐long supportive therapy if cure cannot be achieved by allogeneic stem cell transplantation. Strategies for ex vivo gene therapy aiming at either re‐establishing normal ß‐globin chain synthesis or at re‐activating fetal γ‐globin chain and HbF expression are currently in clinical development. The European Medicine Agency (EMA) conditionally licensed gene addition therapy based on lentiviral transduction of hematopoietic stem cells in 2019 for a selected group of patients with transfusion dependent non‐ß° thalassemia major without a suitable stem cell donor. Gene therapy thus offers a relevant chance to this group of patients for whom cure has previously not been on the horizon. In this review, we discuss the potential and the challenges of gene addition and gene editing strategies for the hemoglobin diseases.
Genus-Wide Characterization of Bumblebee Genomes Provides Insights into Their Evolution and Variation in Ecological and Behavioral Traits
Authors: Cheng Sun, Jiaxing Huang, Yun Wang, Xiaomeng Zhao, Long Su, Gregg W C Thomas, Mengya Zhao, Xingtan Zhang, Irwin Jungreis, Manolis Kellis, Saverio Vicario, Igor V Sharakhov, Semen M Bondarenko, Martin Hasselmann, Chang N Kim, Benedict Paten, Luca Penso-Dolfin, Li Wang, Yuxiao Chang, Qiang Gao, Ling Ma, Lina Ma, Zhang Zhang, Hongbo Zhang, Huahao Zhang, Livio Ruzzante, Hugh M Robertson, Yihui Zhu, Yanjie Liu, Huipeng Yang, Lele Ding, Quangui Wang, Dongna Ma, Weilin Xu, Cheng Liang, Michael W Itgen, Lauren Mee, Gang Cao, Ze Zhang, Ben M Sadd, Matthew W Hahn, Sarah Schaack, Seth M Barribeau, Paul H Williams, Robert M Waterhouse, Rachel Lockridge Mueller
Journal: Molecular Biology and Evolution (2020)

Bumblebees are a diverse group of globally important pollinators in natural ecosystems and for agricultural food production. With both eusocial and solitary life-cycle phases, and some social parasite species, they are especially interesting models to understand social evolution, behavior, and ecology. Reports of many species in decline point to pathogen transmission, habitat loss, pesticide usage, and global climate change, as interconnected causes. These threats to bumblebee diversity make our reliance on a handful of well-studied species for agricultural pollination particularly precarious. To broadly sample bumblebee genomic and phenotypic diversity, we de novo sequenced and assembled the genomes of 17 species, representing all 15 subgenera, producing the first genus-wide quantification of genetic and genomic variation potentially underlying key ecological and behavioral traits. The species phylogeny resolves subgenera relationships, whereas incomplete lineage sorting likely drives high levels of gene tree discordance. Five chromosome-level assemblies show a stable 18-chromosome karyotype, with major rearrangements creating 25 chromosomes in social parasites. Differential transposable element activity drives changes in genome sizes, with putative domestications of repetitive sequences influencing gene coding and regulatory potential. Dynamically evolving gene families and signatures of positive selection point to genus-wide variation in processes linked to foraging, diet and metabolism, immunity and detoxification, as well as adaptations for life at high altitudes. Our study reveals how bumblebee genes and genomes have evolved across the Bombus phylogeny and identifies variations potentially linked to key ecological and behavioral traits of these important pollinators.