AB0725 ASSOCIATION BETWEEN RADIOGRAPHIC PROGRESSION AND CARDIOVASCULAR RISK IN SPONDYLOARTHRITIS: DATA FROM COSPAR REGISTRY
Authors: Ladehesa Pineda Lourdes, Gómez García Ignacio, María del Carmen Castro Villegas, Pedro Seguí Azpilcueta, Maria del Carmen Abalos-Aguilera, Bautista aguilar Laura, Inmaculada Concepcion Aranda-Valera, Rocio Segura, Rafaela Ortega Castro, Clementina López-Medina, Pérez Sánchez Laura, Puche Larrubia Maria Ángeles, Chary Lopez-Pedrera, Font Ugalde Pilar, Garrido Castro Juan Luis, Alejandro Escudero Contreras, Eduardo Collantes Estevez, Jiménez Gómez Yolanda
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background:</h3> Studies suggest that radiographic damage is associated with cardiovascular (CV) risk in axial spondyloarthritis (axSpA). However, the relationship among disease characteristics directly related to structural damage and CV risk has not yet been fully clarified. <h3>Objectives:</h3> To analyze the association of structural damage with the presence of atherosclerotic plaques via carotid ultrasound (US) and the increased CV risk in a registry of patients with SpA. <h3>Methods:</h3> Eighty-five patients with SpA (ASAS criteria) from the SpA registry from Cordoba (CoSpaR) were selected for a cross-sectional study and underwent a complete clinical history, physical examination and biochemical analysis. Variables about demographics, clinical parameters and CV risk factors were collected. CV risk was evaluated by estimating SCORE index and assessing presence of atherosclerotic plaques through carotid US performed by a qualified radiologist. Independent-samples t test was used to evaluate the association between radiological characteristics and presence of atherosclerosis. Multiple lineal regression (MLR) was performed to assess the variables potentially associated with increased SCORE. All comparisons were bilateral. <h3>Results:</h3> Baseline characteristics are shown in the table. Values are mean±SD for quantitative and N (%) for qualitative variables. Regarding characteristics related with radiographic damage and CV risk, they exhibited a mSASSS of 14.84±18.4 (7.27±9.64 in cervical spine and 7.72±10.14 in lumbar spine). Average BMI 26.88±4.13, 33 (38.8%) were smokers, 16 (18.8%) had diagnosis of arterial hypertension, 1 (1.2%) of diabetes mellitus, 13 (15.3%) of hyperlipidemia, and 8 (9.4%) took lipid lowering drugs. Examination with carotid US found that 14 (16.5%) patients had previously unknown atherosclerotic plaques. After classification according to SCORE index, 60 (76.9%) had low CV risk, 10 (12.8%) moderate, and both high and very high CV risk categories had 4 (5.1%) patients each. In patients with atherosclerotic plaques, age, disease duration and variables related to radiographic damage (mSASSS [total, cervical and lumbar], and bone bridges) were significantly higher (p&lt;0.05). In addition, mSASSS in cervical spine (p=0.063) and age (p&lt;0.001) were associated with the SCORE and were predictors of increased CV risk in MLR analysis. <h3>Conclusion:</h3> Presence of atherosclerosis is associated with age, disease duration and radiographic damage in SpA. Age and structural damage especially in the cervical spine predicted a greater CV risk. Thus, it is important to identify these patients in order to maintain tight control and avoid development of CV disease. <h3>Acknowledgement:</h3> <b>Funded by: JA PI-0139-2017</b> <h3>Disclosure of interests:</h3> Ladehesa Pineda Lourdes: None declared, Gómez García Ignacio: None declared, María del Carmen Castro Villegas Paid instructor for: MSD, abbvie, Pfizer, Janssen, Lilly, Roche, Pedro Seguí azpilcueta: None declared, Maria del Carmen abalos-Aguilera: None declared, Bautista aguilar Laura: None declared, inmaculada Concepcion aranda-Valera: None declared, Rocio Segura: None declared, Rafaela Ortega Castro: None declared, Clementina López-Medina: None declared, Pérez Sánchez Laura: None declared, Puche Larrubia Maria Ángeles: None declared, Chary Lopez-Pedrera: None declared, Font Ugalde Pilar: None declared, Garrido Castro Juan Luis: None declared, alejandro Escudero Contreras: None declared, Eduardo Collantes Estevez: None declared, Jiménez Gómez Yolanda: None declared