The Evaluation of Antihypertensive Therapy Cooperative Clinical Trial Method
Authors: WILLIAM M. SMITH
Journal: Annals of Internal Medicine (1964)

Article1 November 1964The Evaluation of Antihypertensive Therapy Cooperative Clinical Trial MethodI. Double-blind Control Comparison of Chlorothiazide, Rauwolfia Serpentina, and HydralazineWILLIAM M. SMITH, M.D. (ASSOCIATE), ANTHONY N. DAMATO, M.D., NICHOLAS J. GALLUZZI, M.D., (ASSOCIATE), CLAUDE F. GARFIELD, M.D., ERNEST G. HANOWELL, M.D., F.A.C.P., WILLIAM H. STIMSON, M.D., F.A.C.P., RICHARD H. THURM, M.D., F.A.C.P., JOHN J. WALSH, M.D., F.A.C.P., LOUIS BROMER, B.A.WILLIAM M. SMITH, M.D. (ASSOCIATE), ANTHONY N. DAMATO, M.D., NICHOLAS J. GALLUZZI, M.D., (ASSOCIATE), CLAUDE F. GARFIELD, M.D., ERNEST G. HANOWELL, M.D., F.A.C.P., WILLIAM H. STIMSON, M.D., F.A.C.P., RICHARD H. THURM, M.D., F.A.C.P., JOHN J. WALSH, M.D., F.A.C.P., LOUIS BROMER, B.A.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-5-829 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe need for adequate clinical trial of therapeutic agents is particularly evident in the field of antihypertensive drugs. It is not possible for individual physicians to evaluate properly the plethora of agents available and recommended for use. The mounting evidence that early and effective therapy is beneficial lends urgency to the need to know which of, or in what combination, these agents are most efficacious and least toxic. Guidelines based on valid clinical trial must be established.Many efforts have lacked validity due to insufficient numbers of cases, lack of appropriate controls, and failure to eliminate bias. The cooperative study...References1. GREENBERG BG: Conduct of cooperative field and clinical trials. Amer. Statist. No. 3: 13, 1959. Google Scholar2. Veterans Administration cooperative study on antihypertensive agents, I. Arch. Intern. Med. (Chicago) 106: 81, 1960. MedlineGoogle Scholar3. FREIS ED: The discrepancy between home and office recordings of blood pressure. Med. Ann. D. C. 23: 1, 1954. MedlineGoogle Scholar4. SCHROEDER HA: Hypertension, method of treatment, in Current Therapy 1954, edited by CONN, W. B. Saunders Co., Philadelphia, 1962, p. 187. Google Scholar5. Veterans Administration cooperative study on antihypertensive agents, III. Arch. Intern. Med. (Chicago) 110: 134, 1962. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Francisco, CaliforniaFrom the U. S. Public Health Service Hospital, San Francisco, Calif.This investigation was supported in part by research grant HE-05311 from the National Institutes of Health, U. S. Public Health Service, Bethesda, Md.This work was presented in part at the American College of Cardiology session at Los Angeles, Calif. on April 1, 1963.Requests for reprints should be addressed to William M. Smith, M.D., U. S. Public Health Service Hospital, 15th Ave. and Lake St., San Francisco, Calif. 94118. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByWilder's principle: pre-treatment value determines post-treatment responseAssessment of antihypertensive therapyComparative trials of terazosin with other antihypertensive agentsRELATION BETWEEN INITIAL BLOOD PRESSURE AND ITS FALL WITH TREATMENTAntihypertensive Effect of DiureticsEFFICACY OF ANTIHYPERTENSIVE DRUGSDivergent effects of antihypertensive therapy on cardiovascular responses and left ventricular function during upright exerciseManagement of Essential HypertensionThe Treatment of Hypertension with DiureticsPrevention of Recurrent Bacteriuria with Continuous Chemotherapy U. S. Public Health Service Cooperative StudyRICHARD B. FREEMAN, M.D., F.A.C.P., LOUIS BROMER, B.A., FRANK BRANCATO, PH.D., STANFORD I. COHEN, M.D., CLAUDE F. GARFIELD, M.D., ROBERT J. GRIEP, M.D., EDWARD J. HINMAN, M.D., JAMES A. RICHARDSON, M.D., F.A.C.P., RICHARD H. THURM, M.D., F.A.C.P., CHRISTFRIED URNER, M.D., WILLIAM M. SMITH, M.D., F.A.C.P.Co-operative Clinical Trial of Alpha-methyldopa III. Double-blind Control Comparison of Alpha-methyldopa and Chlorothiazide, and Chlorothiazide and RauwolfiaWILLIAM M. SMITH, M.D., F.A.C.P., BRUCE BACHMAN, M.D., JAMES G. GALANTE, M.D., ERNEST G. HANOWELL, M.D., F.A.C.P., WILLARD P. JOHNSON, M.D., CHARLES E. KOCH JR., M.D., STANLEY D. KORFMACHER, M.D., RICHARD H. THURM, M.D., F.A.C.P., LOUIS BROMER, B.A.Assessment of antihypertensive therapyPhysiological and Pharmacological Interactions of Antihypertensive DrugsComparative studies of methyldopa and placebo in hospitalized hypertensive patients 1 November 1964Volume 61, Issue 5_Part_1Page: 829-846KeywordsAntihypertensive drug therapyClinical trialsDrugsHeartHypertensionMedical servicesPrevention, policy, and public healthResearch grantsResearch laboratories Issue Published: 1 November 1964 CopyrightCopyright ©, 1964, by The American College of PhysiciansPDF DownloadLoading ...