tbuckley/cabot-search huggingface dataset:
<i>Vital Signs</i>: Trends in <i>Staphylococcus aureus</i> Infections in Veterans Affairs Medical Centers — United States, 2005–2017
Authors: Makoto Jones, John A. Jernigan, Martin E. Evans, Gary A. Roselle, Kelly M. Hatfield, Matthew H. Samore
Journal: MMWR Morbidity and Mortality Weekly Report (2019)

By 2007, all Department of Veterans Affairs medical centers (VAMCs) had initiated a multifaceted methicillin-resistant Staphylococcus aureus (MRSA) prevention program. MRSA and methicillin-susceptible S. aureus (MSSA) infection rates among VAMC inpatients from 2005 to 2017 were assessed.Clinical microbiology data from any patient admitted to an acute-care VAMC in the United States from 2005 through 2017 and trends in hospital-acquired MRSA colonization were examined.S. aureus infections decreased by 43% overall during the study period (p<0.001), driven primarily by decreases in MRSA, which decreased by 55% (p<0.001), whereas MSSA decreased by 12% (p = 0.003). Hospital-onset MRSA and MSSA infections decreased by 66% (p<0.001) and 19% (p = 0.02), respectively. Community-onset MRSA infections decreased by 41% (p<0.001), whereas MSSA infections showed no significant decline. Acquisition of MRSA colonization decreased 78% during 2008-2017 (17% annually, p<0.001). MRSA infection rates declined more sharply among patients who had negative admission surveillance MRSA screening tests (annual 9.7% decline) compared with those among patients with positive admission MRSA screening tests (4.2%) (p<0.05).Significant reductions in S. aureus infection following the VAMC intervention were led primarily by decreases in MRSA. Moreover, MRSA infection declines were much larger among patients not carrying MRSA at the time of admission than among those who were. Taken together, these results suggest that decreased MRSA transmission played a substantial role in reducing overall S. aureus infections at VAMCs. Recent calls to withdraw infection control interventions designed to prevent MRSA transmission might be premature and inadvisable, at least until more is known about effective control of bacterial pathogen transmission in health care settings. Effective S. aureus prevention strategies require a multifaceted approach that includes adherence to current CDC recommendations for preventing not only device- and procedure-associated infections, but also transmission of health care-prevalent strains.
PARADOXICAL INTRAVENTRICULAR SYSTOLIC FLOW PREDICTS HOSPITALIZATION FOR HEART FAILURE IN PATIENTS WITH LEFT VENTRICULAR SYSTOLIC DYSFUNCTION
Authors: Iwona Swiatkiewicz, Sachiyo Igata, Marin Nishimura, Monet Strachan, Ajit Raisinghani, Anthony DeMaria
Journal: Journal of the American College of Cardiology (2019)
MALIGNANT COURSE OF AN ANOMALOUS CORONARY ARTERY IN A TRANSPLANTED HEART
Authors: Estefania Oliveros, Sunil Pauwaa, Ambar Andrade, Gregory Macaluso, Patroklos Pappas, Michael Bresticker, Antone Tatooles, William Cotts, Shermeen Memon
Journal: Journal of the American College of Cardiology (2019)
BALLOON ANGIOPLASTY OF PERIPHERAL THROMBOSIS IN THE PULMONARY ARTERY AS A PALLIATIVE TREATMENT STRATEGY FOR CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION
Authors: Karen Petrosian, Sergey Gorbachevskiy, Andrey Sobolev, Gulamzhan Dadabaev, Issa Jeblawi, Kamol Rakhmonov, Leo Bockeria, Vadimir Losev
Journal: Journal of the American College of Cardiology (2019)
“DE NOVO” HEART FAILURE: A MECHANISM UNDERSCORING SEX DIFFERENCES IN OUTCOMES AFTER ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION
Authors: Edina Cenko, Mihaela van der Schaar, Jinsung Yoon, Olivia Manfrini, Zorana Vasiljevic, Sasko Kedev, Marija Vavlukis, Milika Asanin, Davor Milicic, Lina Badimon, Raffaele Bugiardini
Journal: Journal of the American College of Cardiology (2019)
PULMONARY EMBOLISM RESPONSE TEAMS: DO THEY RESULT IN BETTER OUTCOMES IN SEVERE PULMONARY EMBOLISM (A SINGLE CENTER RETROSPECTIVE ANALYSIS)?
Authors: Shayan Nabavi Nouri, Mahesh Madhavan, Heidi S. Lumish, Michael Lavelle, Michael Gavalas, Tyler Brown, Jianhua Li, Erika Berman Rosenzweig, Sahil Parikh, Ajay Kirtane, Arthur Garan, Daniel Brodie, Cara Agerstrand, Koji Takeda, Sanjum Sethi, Philip Green, Andrew Einstein
Journal: Journal of the American College of Cardiology (2019)
BRAF Inhibition: Bridge or Boost to T-cell Therapy?
Authors: Stephanie L. Goff, Steven A. Rosenberg
Journal: Clinical Cancer Research (2019)

The concept of treatment-refractory disease has evolved as checkpoint modulation has changed the therapeutic landscape for patients with metastatic melanoma. Developing meaningful salvage strategies will involve the exploration of combination therapies and new immunotherapeutics, including adoptive transfer of tumor-infiltrating lymphocytes or other T-cell-based therapy.See related article by Atay et al., p. 2783.
RAPID IMPLANTATION AND RIGHT ANTERIOR MINITHORACOTOMY APPROACH FOR SURGICAL AVR IN ELDERLY PATIENTS
Authors: Gabriele Tamagnini, Liborio Mammana, Carla Beggino, Marco Paris, Matteo Saccocci, Josè Luis Zulueta, Marianna Nardozza, Elisa Mikus, Mauro Del Giglio
Journal: Journal of the American College of Cardiology (2019)
PATIENT HEALTH STATUS TRAJECTORIES IN HEART FAILURE WITH RECOVERED EJECTION FRACTION
Authors: Peter Wohlfahrt, Jose Nativi-Nicolau, Mingyuan Zhang, Craig Selzman, Tom Greene, Jorge Conte, Joshua Biber, Rachel Hess, Omar Wever-Pinzon, Stavros Drakos, Edward Gilbert, Line Kemeyou, Bernie LaSalle, Abdallah Kfoury, Benjamin Steinberg, Rashmee Shah, James Fang, John A. Spertus, Josef Stehlik
Journal: Journal of the American College of Cardiology (2019)
Abstract 20583: Sortilin Promotes Secretion of Apolipoprotein(a) by Hepatic Cells
Authors: Matthew Gemin, Rocco Romagnuolo, Adam D McIntyre, Corey A Scipione, Nabil G Seidah, Michael B Boffa, Robert A Hegele, Marlys L Koschinsky
Journal: Circulation (2016)

Introduction: Lp(a) is a unique lipoprotein species consisting of an LDL-like moiety that is covalently linked to the hallmark glycoprotein apo(a). Plasma concentrations of Lp(a) vary enormously in...
PATIENTS WITH SEVERE PULMONARY ARTERIAL HYPERTENSION TREATED WITH ABI-009, NAB-SIROLIMUS, AN MTOR INHIBITOR: INTERIM RESULTS FROM A PHASE 1 CLINICAL TRIAL
Authors: Marc Simon, Mardi Gomberg-Maitland, Ronald Oudiz, Roberto Machado, Franz Rischard, Jason Elinoff, Berta Grigorian, Anita Schmid, Shihe Hou, Neil Desai, Mark Gladwin
Journal: Journal of the American College of Cardiology (2019)
A WOMAN WITH ISCHEMIA AND NON-OBSTRUCTIVE CORONARY ARTERY DISEASE WITH CORONARY MICROVASCULAR DYSFUNCTION WITH ABNORMAL SPECT FINDINGS: FACT OR ARTIFACT
Authors: Nissi Sharon Suppogu, Haider Aldiwani, Odayme Quesada, Janet Wei, Chrisandra Shufelt, Bruce Samuels, C. Noel Bairey Merz
Journal: Journal of the American College of Cardiology (2019)
GALECTIN-3 AS A RISK PREDICTOR OF LONG-TERM MORTALITY IN THE RESUSCITATED COHORTS OF SUDDEN CARDIAC ARREST
Authors: Sharma Kattel, Hardik Bhatt, Wassim Mosleh, Milind Chaudhari, Zaid Al-Jebaje, Charl Khalil, Sahoor Khan, Kevin Frodey, Umesh Sharma
Journal: Journal of the American College of Cardiology (2019)
Use of autologous<sup>99m</sup>Technetium-labelled neutrophils to quantify lung neutrophil clearance in COPD
Authors: Nicola Tregay, Malcolm Begg, Anthony Cahn, Neda Farahi, Kathryn Povey, Sujith Madhavan, Rosalind Simmonds, Daniel Gillett, Chandra Solanki, Anna Wong, Joanna Maison, Mark Lennon, Glyn Bradley, Emily Jarvis, Marius de Groot, Fred Wilson, Judith Babar, A Michael Peters, Edith M Hessel, Edwin R Chilvers
Journal: Thorax (2019)

Rationale There is a need to develop imaging protocols which assess neutrophilic inflammation in the lung. Aim To quantify whole lung neutrophil accumulation in (1) healthy volunteers (HV) following inhaled lipopolysaccharide (LPS) or saline and (2) patients with COPD using radiolabelled autologous neutrophils and single-photon emission computed tomography/CT (SPECT/CT). Methods 20 patients with COPD (Global initiative for chronic obstructive lung disease (GOLD) stages 2–3) and 18 HVs were studied. HVs received inhaled saline (n=6) or LPS (50 µg, n=12) prior to the injection of radiolabelled cells. Neutrophils were isolated using dextran sedimentation and Percoll plasma gradients and labelled with 99m Technetium (Tc)-hexamethylpropyleneamine oxime. SPECT was performed over the thorax/upper abdomen at 45 min, 2 hours, 4 hours and 6 hours. Circulating biomarkers were measured prechallenge and post challenge. Blood neutrophil clearance in the lung was determined using Patlak-Rutland graphical analysis. Results There was increased accumulation of 99m Tc-neutrophils in the lungs of patients with COPD and LPS-challenged subjects compared with saline-challenged subjects (saline: 0.0006±0.0003 mL/min/mL lung blood distribution volume [mean ±1 SD]; COPD: 0.0022±0.0010 mL/min/mL [p&lt;0.001]; LPS: 0.0025±0.0008 mL/min/mL [p&lt;0.001]). The accumulation of labelled neutrophils in 10 patients with COPD who underwent repeat radiolabelling/imaging 7–10 days later was highly reproducible (0.0022±0.0010 mL/min/mL vs 0.0023±0.0009 mL/min/mL). Baseline interleukin (IL)-6 levels in patients with COPD were elevated compared with HVs (1.5±1.06 pg/mL [mean ±1 SD] vs 0.4±0.24 pg/mL). LPS challenge increased the circulating IL-6 levels (7.5±2.72 pg/mL) 9 hours post challenge. Conclusions This study shows the ability to quantify ‘whole lung’ neutrophil accumulation in HVs following LPS inhalation and in subjects with COPD using autologous radiolabelled neutrophils and SPECT/CT imaging. Moreover, the reproducibility observed supports the feasibility of using this approach to determine the efficacy of therapeutic agents aimed at altering neutrophil migration to the lungs.
PACING THERAPIES FOR SLEEP APNEA AND CARDIOVASCULAR OUTCOMES
Authors: Sharan Sharma, Bader Madoukh, Sindhuja Palle, Donita Atkins, Sudharani Bommana, Prajwala Lakkireddy, Naresh Kodwani, Brian Mieczkowski, Peter Park, Rangarao Tummala, Rakesh Gopinathannair, Sanghamitra Mohanty, Andrea Natale, Dhanunjaya Lakkireddy
Journal: Journal of the American College of Cardiology (2019)
ACUTE AORTIC INSUFFICIENCY AND VENTRICULAR TACHYCARDIA SECONDARY TO AXILLARY INTRA-AORTIC BALLOON PUMP MIGRATION
Authors: Nicolas Isaza, Azucena Martinez, Jhonattan Benavides, Adriana Posada, Juan Hernando Del Portillo, Daniel Isaza-Restrepo, Jaime R. Cabrales
Journal: Journal of the American College of Cardiology (2019)
INCREASED RISK OF SEVERE HYPOGLYCEMIC EVENTS BEFORE AND AFTER CARDIOVASCULAR EVENTS IN TYPE 2 DIABETES: VALIDATION OF A NOVEL CONCEPT
Authors: Eberhard Standl, Susanna Stevens, Yuliya Lokhnygina, John Buse, Aldo Maggioni, Robert Mentz, Ambady Ramachandran, Adrian Hernandez, Rury Holman
Journal: Journal of the American College of Cardiology (2019)
Chemotherapy-Induced Peripheral Neuropathy
Authors: Timothy J Brown, Ramy Sedhom, Arjun Gupta
Journal: JAMA Oncology (2019)

Chemotherapy-Induced Peripheral NeuropathyPeripheral neuropathy refers to symptoms arising from damage to peripheral nerves.These nerves carry sensation, control movements of the arms and legs, and control the bladder and bowel.Chemotherapy and other drugs used to treat cancer can cause peripheral neuropathy.This is termed chemotherapy-induced peripheral neuropathy (or CIPN).
VALIDATION AND QUANTIFICATION OF MYOCARDIAL FIBROSIS WITH CARDIAC MAGNETIC RESONANCE AND LEFT VENTRICULAR MYOCARDIAL BIOPSY
Authors: Muzna Hussain, Eoin Donnellan, Carmela Tan, E. Rene Rodriguez, Chris Watson, Christine Moravec, Wai Hong Tang, Edward Soltesz, Gosta Pettersson, Brian Griffin, Patrick Collier, Deborah Kwon
Journal: Journal of the American College of Cardiology (2019)
Abstract 113: Steering Fibroblast Phenotype to Promote Left Ventricular Scar Maturation and Function Post-MI
Authors: Lisandra E de Castro Brás
Journal: Circulation Research (2018)

The prevalence for myocardial infarction (MI) in the US is ~7.9 million. Although current therapies have significantly improved survival rate, adverse left ventricular (LV) remodeling still occurs in nearly 40% of MI patients. The size, composition, and mechanical properties of the scar that forms post-MI determines patient outcomes. Scar formation is mostly driven by inflammatory factors and fibroblast differentiation into myofibroblast. Suppression of inflammation and fibrosis, however, have led to unexpected results, including infarct expansion and LV wall thinning. Recently our lab uncovered that extracellular matrix (ECM) degradation post-MI releases collagen derived fragments that are biologically active. Using a synthesized peptide mimetic of one such fragment - p1158/59 - we found that p1158/59 dynamically interacts with fibroblasts regulating cell migration and the type and amount of collagen deposited post-MI. We hypothesize that p1158/59 binds to fibroblasts to delay or prevent myofibroblast differentiation, which promotes scar stabilization by controlled secretion of ECM and scar maturation. Fibroblasts were isolated from mice LV and incubated with vehicle or p1158/59 in serum free media. Complete media (10% FBS) and TGFb were used as positive controls respectively for migration and myofibroblast activation. We assessed fibroblast phenotype and ECM secretion. Mice were treated with p1158/59 post-MI and mid- and long-term LV remodeling and function assessed. p1158/59 promoted fibroblast migration to levels similar to positive control. Surprisingly, this was not accompanied by increased alpha smooth muscle actin (i.e. myofibroblast activation). Mice treated with p1158/59 for 7 days (D7) post-MI presented less collagen deposition with decreased LV dilation compared to controls. At D14 post-MI, p1158/59 repressed expression of pro-angiogenic factors and promoted fiber alignment and cellular apoptosis, which resulted in improved cardiac function, providing proof-of-concept that p1158/59 reduces adverse LV remodeling. These data suggest that p1158/59 modulates scar formation and remodeling post-MI by delaying or partially inhibiting fibroblast phenotype transition and promoting scar stabilization and maturation.
THE POTENTIAL ROLE OF ALCOHOL CONSUMPTION IN AORTIC ROOT DILATATION: INSIGHTS FROM THE CORINTHIA STUDY
Authors: Sotirios Tsalamandris, Evangelos Oikonomou, Evangelia Christoforatou, Christos Chasikidis, George-Angelo Papamikroulis, Georgia Vogiatzi, Evgenia Bourouki, Effimia Zacharia, Maria Anastasiou, Margienti Papakonstantinou, Dimitris Tousoulis
Journal: Journal of the American College of Cardiology (2019)
THIRTY-DAY READMISSION AFTER UNDERGOING PERCUTANEOUS CORONARY INTERVENTION WITH ATRIAL FIBRILLATION
Authors: Toka Hamaguchi, Yusuke Morita, Tetsuya Haruna, Yoshisumi Haruna, Eisaku Nakane, Yuhei Yamaji, Hideyuki Hayashi, Michiya Hanyu, Moriaki Inoko
Journal: Journal of the American College of Cardiology (2019)
Left Ventricular Thrombus
Authors: Cian P. McCarthy, Sean Murphy, Ramkumar V. Venkateswaran, Avinainder Singh, Leslie L. Chang, Melvin G. Joice, Jose M. Rivero, Muthiah Vaduganathan, James L. Januzzi, Deepak L. Bhatt
Journal: Journal of the American College of Cardiology (2019)
Abstract 360: Effective Three-element Windkessel Model based on Doppler Ultrasound Images for Noninvasive Quantification of Trans-stenotic Pressure Gradient in Aortorenal System
Authors: Monsurul Khan, Alan P Sawchuk, Anurag Deb, Rou Chen, Raghu L Motaganahalli, Xin Fang, Huidan(Whitney) Yu
Journal: Circulation Research (2018)

The research objective is to develop and validate a noninvasive method to quantify trans-stenotic pressure gradient in aortorenal system through image-based computational hemodynamics (ICH) for supporting clinical decision of stenting therapy. Renal artery stenosis (RAS) causes renovascular hypertension but the true severity of RAS is hard to be determined thus effective stenting therapy cannot be well planned. We hypothesize that the trans-stenotic pressure gradient truly reflects the severity of RAS. Recently, ICH has merged as a unique tool, using clinical CT and Doppler images as well as the 3-element WindKessel model. As schematized in Fig. 1(a), ICH noninvasively quantify the live hemodynamics, e.g. pressure in Fig. 1(b), in human vessels. One challenge in ICH is to introduce the appropriate values of proximal resistance (r), distal resistance (R), and compliance (C). We have developed a comprehensive algorithm to determine these values by comparing the computational flow-rates at the exits of aortic artery (AA), left renal (LR), and right renal (RR) arteries with the corresponding flow-rates from Doppler images. The image data of the study case consist of CT data, Doppler images at the juxtarenal AA, LR and RR arteries, and invasive pressure measurement at the corresponding arteries from pressure wire transducers. The r, R, and C values determined through the Doppler images are shown in Fig. 19(c). The three non-invasively computed pressure waves are in good agreements with the invasively measured pressure waves (Fig. 1(d)). The validated ICH is a practical tool to noninvasively measure pressure gradients so that physicians can make better decision at treatment of RAS.
HEALTH LITERACY AND CARDIOVASCULAR KNOWLEDGE WORKSHOP FOR WOMEN FROM DISADVANTAGED COMMUNITIES
Authors: Donna R. Zwas, Keren Greenberg, Elisheva Leiter, Maha Nubani Husseini, Nisreen Agbaria, Sima Wetzler, Iva Littman, Chaim Lotan, Milka Donchin
Journal: Journal of the American College of Cardiology (2019)
Centrally located lung cancer and risk of occult nodal disease: an objective evaluation of multiple definitions of tumour centrality with dedicated imaging software
Authors: Roberto F. Casal, Boris Sepesi, Ala-Eddin S. Sagar, Juerg Tschirren, Minxing Chen, Liang Li, Jennifer Sunny, Joyce Williams, Horiana B. Grosu, George A. Eapen, Carlos A. Jimenez, David E. Ost
Journal: European Respiratory Journal (2019)

Introduction Current guidelines recommend invasive mediastinal staging in patients with centrally located radiographic stage T1N0M0 nonsmall cell lung cancer (NSCLC). The lack of a specific definition of a central tumour has resulted in discrepancies among guidelines and heterogeneity in practice patterns. Methods Our objective was to study specific definitions of tumour centrality and their association with occult nodal disease. Pre-operative chest computed tomography scans from patients with clinical (c) T1N0M0 NSCLC were processed with a dedicated software system that divides the lungs in thirds following vertical and concentric lines. This software accurately assigns tumours to a specific third based both on the location of the centre of the tumour and its most medial aspect, creating eight possible definitions of central tumours. Results 607 patients were included in our study. Surgery was performed for 596 tumours (98%). The overall pathological (p) N disease was: 504 (83%) N0, 56 (9%) N1, 47 (8%) N2 and no N3. The prevalence of N2 disease remained relatively low regardless of tumour location. Central tumours were associated with upstaging from cN0 to any N (pN1/pN2). Two definitions were associated with upstaging to any N: concentric lines, inner one-third, centre of the tumour (OR 3.91, 95% CI 1.85–8.26; p&lt;0.001) and concentric lines, inner two-thirds, most medial aspect of the tumour (OR 1.91, 95% CI 1.23–2.97; p=0.004). Conclusions We objectively identified two specific definitions of central tumours. While the rate of occult mediastinal disease was relatively low regardless of tumour location, central tumours were associated with upstaging from cN0 to any N.
SINGLE AND COMBINED EFFECTS OF PERIPHERAL ARTERY DISEASE AND OF TYPE 2 DIABETES MELLITUS ON THE RISK OF CARDIOVASCULAR EVENTS IN WOMEN
Authors: Christoph H. Saely, Marc Schindewolf, Alexander Vonbank, Christine Heinzle, Daniela Purin, Barbara Larcher, Arthur Mader, Andreas Leiherer, Axel Muendlein, Heinz Drexel, Iris Baumgartner
Journal: Journal of the American College of Cardiology (2019)
Increased IgA Expression in Lung Lymphoid Follicles in Severe Chronic Obstructive Pulmonary Disease
Authors: Maha Zohra Ladjemi, Clémence Martin, Marylène Lecocq, Bruno Detry, Frank Aboubakar Nana, Charlotte Moulin, Birgit Weynand, Chantal Fregimilicka, Caroline Bouzin, Pascal Thurion, François Carlier, Jef Serré, Ghislaine Gayan-Ramirez, Monique Delos, Sebahat Ocak, Pierre Régis Burgel, Charles Pilette
Journal: American Journal of Respiratory and Critical Care Medicine (2018)

Accumulation of B cells and lymphoid follicles (LFs) has been described in chronic obstructive pulmonary disease (COPD) airways, but the functional status of lung B cells remains poorly known.To characterize LFs for expression of IgA, the main mucosal antibody.The presence of B cells and LFs, including intrafollicular IgA expression, were determined in the lung from patients with COPD (n = 37) versus control subjects (n = 34) by immunohistochemistry. We also evaluated follicular IgA responses in the lungs from mice infected with Pseudomonas aeruginosa (PAO1) (n = 10 per group) and in smoking mice.Whereas in smokers B-cell numbers slightly increased, robust increases in B-cell and LF numbers (mainly in distal airways) were only observed in severe COPD. Most follicular B cells were IgM+ (70-80%), but IgA+ (and not IgG+) B-cell numbers were increased in LFs from severe COPD compared with control subjects (twofold, 44.7% vs. 25.2%), and this was significant in distal but not proximal airways. Follicular IgA response was also observed in PAO1-infected mouse lungs, but not after smoke exposure. Moreover, follicular IgA expression associated with expression of IL-21, which was very potent to activate immunoglobulin production in vitro.This study shows that IgA production occurs in peribronchiolar LFs from severe COPD, where IL-21-producing T cells are present, and presumably represents a feature of exacerbated mucosal adaptive immune responses against microbial and/or self-antigens.
Improved Time in Range and Glycemic Variability With Sotagliflozin in Combination With Insulin in Adults With Type 1 Diabetes: A Pooled Analysis of 24-Week Continuous Glucose Monitoring Data From the inTandem Program
Authors: Thomas Danne, Bertrand Cariou, John B. Buse, Satish K. Garg, Julio Rosenstock, Phillip Banks, Jake A. Kushner, Darren K. McGuire, Anne L. Peters, Sangeeta Sawhney, Paul Strumph
Journal: Diabetes Care (2019)

OBJECTIVE To evaluate effects of the dual sodium–glucose cotransporter (SGLT) 1 and SGLT2 inhibitor sotagliflozin in combination with insulin on glucose time in range (TIR) and glucose excursions, postprandial glucose (PPG), and other glycemic metrics in adults with type 1 diabetes using masked continuous glucose monitoring (CGM). RESEARCH DESIGN AND METHODS Data sets from the inTandem1 (clinical trial reg. no. NCT02384941) and inTandem2 (clinical trial reg. no. NCT02421510) double-blind randomized trials evaluating sotagliflozin versus placebo in adults with type 1 diabetes treated with optimized insulin were pooled for analyses of masked CGM data from a subset of participants in each trial. The pooled cohort included patients randomized to receive placebo (n = 93), sotagliflozin 200 mg (n = 89), or sotagliflozin 400 mg (n = 96). The primary outcome was change from baseline to week 24 in glucose TIR (3.9–10.0 mmol/L [70–180 mg/dL]). Secondary end points included time below and above the target range and 2-h PPG level assessed after a standardized mixed meal. RESULTS Mean percentage of glucose TIR/percentage time spent at &amp;lt;3.9 mmol/L (&amp;lt;70 mg/dL) during week 24 was 51.6%/5.9%, 57.8%/5.5%, and 64.2%/5.5% with placebo, sotagliflozin 200 mg, and sotagliflozin 400 mg, respectively, which corresponded to a placebo-adjusted change from a baseline of +5.4%/−0.3% (P = 0.026; +1.3/−0.1 h/day) for sotagliflozin 200 mg and +11.7%/−0.1% (P &amp;lt; 0.001; +2.8/−0.02 h/day) for sotagliflozin 400 mg. Placebo-adjusted PPG reductions were 1.9 ± 0.7 mmol/L (35 ± 13 mg/dL; P = 0.004) and 2.8 ± 0.7 mmol/L (50 ± 13 mg/dL; P &amp;lt; 0.001) with sotagliflozin 200 and 400 mg, respectively. CONCLUSIONS Combined with optimized insulin in type 1 diabetes, sotagliflozin significantly increased glucose TIR without increasing time spent at &amp;lt;3.9 mmol/L and reduced PPG, thereby improving glycemic control.