tbuckley/cabot-search huggingface dataset:
Scrapie can be transmitted to mice by instillation of inoculum into the conjunctiva
Authors: J. R Fraser, J. D Foster, H. Fraser
Journal: BMJ (1996)

these animals had died of bovine spongiform encephalopathy,7 although the details of the experiment have not been published.Furthermore, since the ban on cannibalistic feeding was imposed in 1988 over 22000 animals have been bom that have subsequently developed bovine spongiform encephalopathy; one was born as recently as June 1993.Interestingly, the range of ages at which the disease was diagnosed in these animals is virtually the same as that in animals born before the ban (table).Distribution of ages of animals with confirmed bovine spongiform encephalopathy bom before and after feed containing recycled animal remains was banned in July 1988.Figures are numbers (percentages) Born before ban, Born after ban, Age disease diagnosed disease diagnosed (years) 19893
Framework to Identify and Prioritize Candidate Inherited Myeloid Malignancy Germline Variants Leveraging the BEAT AML Cohort
Authors: Daniel Bottomly, Nicola Long, Fei Yang, Tiffany Lee, Uma Borate, Beth Wilmot, Adam S DuVall, Andrea Monteblanco, Karina Thiel-Klare, Gabby Dewson, Richard D. Press, Cristina E. Tognon, Brian J. Druker, Jeffrey W. Tyner, Shannon K. McWeeney, Anupriya Agarwal
Journal: Blood (2019)
Invited commentary on “postoperative outcomes in elderly patients undergoing pancreatic resection for pancreatic adenocarcinoma: A systematic review and meta-analysis”. Int J Surg. 2019 Sep 30. pii: S1743-9191(19)30262–6. doi: 10.1016/j.ijsu.2019.09.030. [Epub ahead of print]
Authors: Aram Baram
Journal: International Journal of Surgery (2019)
CBMT-24. CHARACTERIZATION OF PRIMARY CILIUM IN RECURRENT GLIOBLASTOMA: IMPLICATIONS FOR NEW THERAPEUTIC TARGETS
Authors: Vittorio Stumpo, Aruljothi Marappian, Quintino Giorgio D’Alessandris, Simone Pacioni, Rina Di Bonaventura, Lara Ebbert, Martina Giordano, Valerio Caccavella, Alessandro Olivi, Maria Laura Falchetti, Lucia Ricci-Vitiani, Roberto Pallini, Jay Gopalakrishnan
Journal: Neuro-Oncology (2019)

Abstract INTRODUCTION Primary cilium is a highly conserved, dynamic cellular organelle which plays several roles in embryonic development, intracellular signaling, and cell cycle. Structural alterations of primary cilium have been described in human gliomas including glioblastoma (GBM), however, its actual role in pathogenesis and treatment resistance of these tumors is largely unknown. METHODS We investigated cilium morphology and expression of cilium-related genes in human glioma of various WHO grade and in couples of patient-derived glioma stem-like cells (GSCs) that were established from the very same GBM at first diagnosis and at recurrence. Immunohistochemistry with anti-Arl13b antibody was used to assess cilium morphology. The expression levels of genes involved in ciliary disassembly complex (CDC) were analyzed by quantitative real-time PCR, using neural progenitor cells (NPCs) as control. Lastly, we assessed 3 GSC cultures that were treated with a drug inhibiting cilia disassembly (CCB-Cil). RESULTS Anaplastic oligodendroglioma and proneural GBM showed the highest percentage of ciliated cells. In GBM, we found the highest percentage of fragmented cilia. GSCs derived from newly diagnosed GBMs displayed lower percentages of ciliated cells than those derived from recurrent GBMs (20% vs 70%). Morphological analysis indicated that GSCs from recurrent GBM show cilia with extremely various morphology compared with GSCs from newly diagnosed GBM and NPCs. Gene analysis showed reduced expression of CDC-related genes in GSCs from newly diagnosed GBM with respect to those from recurrent GBMs. CCB-Cil treatment determined a global reduction of CDC-related genes, increased expression of differentiation markers (GFAP), and reduction of stemness markers (SOX2). CONCLUSIONS The increased percentage of ciliated cells in GSCs from recurrent GBM may be related to a compensatory response of CDC and to an accelerated ciliary turnover. Blocking cilia disassembly reduces stemness features and induces differentiation in GSCs, suggesting that this approach could represent a promising strategy for targeting GBM.
CMET-11. RESPONSE TO STEREOTACTIC RADIOSURGERY FOR MULTIPLE BRAIN METASTASES BASED ON HISTOLOGY-SPECIFIC SUBTYPE STATUS
Authors: Michael K Rooney, James Chandler, John Kalapurakal, Roger Stupp, Maciej S Lesniak, Adam Sonabend, Priya Kumthekar, Matthew Tate, Timothy Kruser, Rimas Lukas, Karan Dixit, Sean Sachdev
Journal: Neuro-Oncology (2019)

Abstract BACKGROUND This retrospective study evaluated the relationship between histologic subtype and treatment outcomes following SRS for the treatment of multiple brain metastases (MBM). METHODS We analyzed patients with MBM, defined here as &gt;= 3 lesions, treated with SRS at our institution. Primary histologies examined were NSCLC, breast, and melanoma. Patients were categorized according to histology-specific subtypes (NSCLC-EGFR, ALK, KRAS, PD-L1%; breast-HER2, ER, PR; melanoma-BRAF). The primary outcome was local control (defined by RANO-BM) and secondary outcomes included intracranial progression-free survival (iPFS) and overall survival (OS). RESULTS 141 patients met inclusion criteria (66 NSCLC, 61 breast, and 14 melanoma). HER2+ and BRAF V600E+ lesions had increased rates of local control following SRS (P=0.0048 and P=0.0256, respectively) compared to other breast/melanoma subtypes. EGFR mutation was not associated with increased local control with SRS (71 vs 74%), but increased iPFS (P=0.0031). On multivariable analysis, EGFR+ was independently associated with a decreased time-dependent risk of death (P=0.011). The use of progressively newer generations of EGFR-directed therapies was associated with stepwise decreasing risk of intracranial progression and death. HER2+ disease had improved iPFS and OS (P=0.0058 and P&lt; 0.0001, respectively; it was not an independent risk factor for progression or death; however, the use of HER2-directed antibodies was associated with decreased risk of death (p=0.036). The use of tyrosine kinase inhibitors (i.e. lapatanib) was not associated with improvements, although this was a small subset. CONCLUSIONS Some histologic subtypes appear to have better control with SRS, with HER2+ breast cancer and BRAF V600E+ melanoma associated with improved outcomes – this requires further validation; a volumetric analysis is pending. This the protective effect of EGFR mutation appears to be partly related to use of EGFR inhibitors, with the use of newer-generation therapies leading to improved outcomes; although local control with SRS remains excellent regardless of the mutation.
<sup>131</sup>I‐Labeled Multifunctional Polyphosphazene Nanospheres for SPECT Imaging‐Guided Radiotherapy of Tumors
Authors: Wei Zhu, Lingzhou Zhao, Yu Fan, Jinhua Zhao, Xiangyang Shi, Mingwu Shen
Journal: Advanced Healthcare Materials (2019)

Abstract Design of theranostic nanoplatforms represents a major topic for current nanomedicine. Here, the preparation of multifunctional poly(cyclotriphosphazene‐ co ‐polyethylenimine) nanospheres (PNSs) labeled with radionuclide 131 I for single photon emission computed tomography (SPECT) imaging‐guided radiotherapy of tumors is reported. In this work, PNSs are prepared using hexachlorocyclotriphosphazene as a crosslinker to crosslink branched polyethylenimine (PEI) via a nucleophilic substitution reaction, modified with 3‐(4′‐hydroxyphenyl) propionic acid‐OSu (HPAO) for 131 I labeling, and reacted with 1,3‐propane sulfonate (1,3‐PS) to render the particles with antifouling property, followed by acetylation of the remaining surface amines and labeling with 131 I. The acquired PNS.NHAc‐HPAO( 131 I)‐PS particles are well characterized. It is shown that the multifunctional PNSs with an average size of 184 ± 29.3 nm exhibit favorable antifouling properties, high 131 I labeling efficiency (76.05 ± 3.75%), and excellent radiostability and colloidal stability. With these properties owned, the developed PNS.NHAc‐HPAO( 131 I)‐PS spheres enable much more efficient SPECT imaging and radiotherapy of a xenografted tumor model in vivo than the PEI counterpart material (PEI.NHAc‐HPAO( 131 I)‐PS). The developed PNSs may be used as a versatile platform for further development of different forms of nanomedicine for various biomedical applications.
A Resident’s Courage
Authors: Shan Ali
Journal: JAMA Oncology (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Prescribing Patterns of Heart Failure-Exacerbating Medications Following a Heart Failure Hospitalization
Authors: Parag Goyal, Jerard Kneifati-Hayek, Alexi Archambault, Krisha Mehta, Emily B Levitan, Ligong Chen, Ivan Diaz, James Hollenberg, Joseph T Hanlon, Mark S Lachs, Mathew S Maurer, Monika M Safford
Journal: JACC Heart Failure (2019)
The Fanconi Anemia-Associated Protein NIPA Is Essential for the Nuclear Abundance of FANCD2
Authors: Stefanie Kreutmair, Miriam Erlacher, Geoffroy Andrieux, Rouzanna Istvanffy, Alina Rudorf, Melissa Zwick, Tamina Rückert, Milena Pantic, Teresa Poggio, Khalid Shoumariyeh, Tony Andreas Müller, Hiroyuki Kawaguchi, Marie Follo, Cathrin Klingeberg, Marcin Wlodarski, Irith Baumann, Dietmar Pfeifer, Michal Kulinski, Martina Rudelius, Simone Lemeer, Bernhard Kuster, Christine Dierks, Christian Peschel, Nina Cabezas-Wallscheid, Jesus Duque-Afonso, Robert Zeiser, Michael Cleary, Detlev Schindler, Annette Schmitt-Graeff, Melanie Boerries, Charlotte M. Niemeyer, Robert A.J. Oostendorp, Justus Duyster, Anna Lena Illert
Journal: Blood (2019)
Comparison of Mycophenolate Mofetil and a Calcineurin Inhibitor Versus Calcineurin Inhibitor Based Graft-Versus-Host-Disease Prophylaxis for Matched Unrelated Donor Transplant for Acute Myeloid Leukemia. a Study from the ALWP of the EBMT
Authors: Annalisa Paviglianiti, Myriam Labopin, Didier Blaise, Gerard Socie, Claude-Eric Bulabois, Celestine Simand, Nathalie Fegueux, Armin Gerbitz, Gaëlle Guillerm, Johan Maertens, Patrice Chevallier, Anne Huynh, Pascal Turlure, Eric Deconinck, Edouard Forcade, Arnon Nagler, Mohamad Mohty
Journal: Blood (2019)
Treatment of hypertensive emergencies with oral labetalol.
Authors: C S Good
Journal: BMJ (1978)

Six patients completed the study.In the remaining five the trial had to be abandoned because of acute flare-up of eczema on both sides (4) or severe itching on both sides (1).In none of the remaining six was there any significant difference in the itching or severity of eczema between the two sides.Only one of these patients showed an overall clinical improvement during the period of the trial.
Letter to the Editor: Diagnosis of Cirrhotic Cardiomyopathy: The Role of an Impaired Cardiac Reserve
Authors: Anoop N. Koshy, Omar Farouque, Paul Calafiore, Paul J. Gow
Journal: Hepatology (2019)

Potential conflict of interest: Nothing to report. To The Editor: We read with interest the article by Izzy et al.1 on redefining the criteria for diagnosis of cirrhotic cardiomyopathy (CCM). The authors should be commended on this document that reflects important contemporary advances in cardiovascular imaging. However, the proposed exclusion of a blunted contractile response on stress testing from the diagnostic criteria warrants discussion. Mechanistic, echocardiographic, and postmortem studies have all suggested pathogenic alterations, including down‐regulation of β‐adrenergic receptors and adverse cardiac remodeling in cirrhosis.2 Despite the resting hypercontractile state, it was postulated, and later proven, that these patients demonstrate an attenuated rise in cardiac output (CO) during exercise and on challenge with inotropic and vasoconstrictor analogs.2 This is of clinical significance, as subclinical cardiac dysfunction that characterizes cirrhosis can be unmasked during periods of physiological stress, including hypovolemia, sepsis, and liver transplantation.2 As such, a normal baseline cardiac function is just one side of the picture. Further, a hyperdynamic resting function, often associated with more severe liver disease, may in fact represent patients encroaching on their cardiac reserve at rest.3 Development of hepatorenal syndrome (HRS) in particular was suggested as a potential consequence of CCM.1 However, contemporary echocardiographic studies at rest have demonstrated no differences in ejection fraction or strain in patients with progressive circulatory dysfunction and HRS.4 This occurred despite significant increases in neurohormonal and sympathetic activity. A recent study from our group of over 500 patients demonstrated a low cardiac reserve (defined as ΔCO < 25% with low‐dose dobutamine) on dobutamine stress testing to be associated with a 4‐fold increased risk of developing HRS.5 Cardiac output in the aforementioned study was estimated using an electrocardiogram‐derived heart rate and a simple and reproducible pulse‐wave doppler estimation of stroke volume that requires no postprocessing software. Variability in study definitions of what constitutes a blunted cardiac reserve certainly limits its clinical application, as highlighted by the authors. Furthermore, requisite use of inotropic or vasoconstrictor agents in addition to standard echocardiographic assessment can increase resource utilization and cost. Nevertheless, the proposal of new diagnostic criteria should not just mirror advances in imaging techniques but also aim to translate present evidence to improving measurable clinical outcomes. Significant challenges remain in the standardization of what constitutes a blunted cardiac reserve in cirrhosis. However, omission of this metric with both pathophysiologic and clinical significance may be premature and could stifle future endeavors to characterize this entity.
TNB-486, a Novel Fully Human Bispecific CD19 x CD3 Antibody That Kills CD19-Positive Tumor Cells with Minimal Cytokine Secretion
Authors: Harbani Malik, Ben Buelow, Udaya Rangaswamy, Aarti Balasubramani, Andrew Boudreau, Kevin Dang, Laura Davison, Shelley Force Aldred, Katherine Marie Harris, Suhasini Iyer, Brett Jorgensen, Duy Pham, Kirthana Prabhakar, Ute Schellenberger, Harshad Ugamraj, Nathan Trinklein, Wim Van Schooten
Journal: Blood (2019)
Intensive Chemotherapy Along with Aggressive Supportive Care Can Spare Stem Cell Transplantation in a Subset of Patients without Compromising an Outcome in Infants with Acute Lymphoblastic Leukemia; A Report from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) Trial MLL-10
Authors: Daisuke Tomizawa, Takako Miyamura, Toshihiko Imamura, Tomoyuki Watanabe, Akiko Moriya Saito, Atsushi Ogawa, Yoshihiro Takahashi, Masahiro Hirayama, Yuki Arakawa, Tomohiko Taki, Takao Deguchi, Toshinori Hori, Sakae Omori, Masami Haba, Akihiro Iguchi, Yuuki Koga, Atsushi Manabe, Keizo Horibe, Eiichi Ishii, Katsuyoshi Koh
Journal: Blood (2019)
Ventricular Safety Pacing Triggered by Right Ventricular Lead Dislodgement
Authors: Mohita Singh, Cody McCoy, James Daniels
Journal: Circulation (2019)

ECG CHALLENGEAn 83-year-old woman with a dual-chamber pacemaker presented to the emergency department with 1 day of fatigue and generalized weakness.The pacemaker was placed 1 year before presentation at an outside facility for second-degree heart block.No previous ECGs were available for review in our system.On arrival, her heart rate was 64 beats/min, and her other vital signs were within normal limits.The 12-lead ECG was recorded during evaluation (Figure 1).We can see an initial atrial pacing artifact and a second ventricular pacing artifact that do not result in ventricular capture.What happened to the right ventricular lead based on the ECG below?Please turn the page to read the diagnosis.
Changes in Gut Microbial Diversity and Correlations with Clinical Outcomes in Patients with Newly Diagnosed Acute Myeloid Leukemia (AML) Receiving Intensive Chemotherapy
Authors: Sangmin Lee, Ellen K. Ritchie, Sumaiya Miah, Caroline Andy, Tania Curcio, Finola Goudy, Michael Hovan, Claire Douglass, Pinkal Desai, Michael B. Samuel, Gail J. Roboz, Michael Satlin
Journal: Blood (2019)
Phase III Clinical Trial of Elizaria® and Soliris® in Adult Patients with Paroxysmal Nocturnal Hemoglobinuria: Results of Comparative Analysis of Efficacy, Safety, and Pharmacological Data
Authors: Aleksandr Kulagin, Vadim Ptushkin, Elena Lukina, Elena Gapchenko, Oksana Markova, Eugene Zuev, Dmitry Kudlay
Journal: Blood (2019)
Transcriptional Regulation of Hematopoietic Stem Cells in Aging and Myelodysplastic Syndrome Reveals DDIT3 As a Potential Driver of Transformation
Authors: Teresa Ezponda, Juan P. Romero, Marina Ainciburu, Ana Alfonso, Nerea Berastegui, Amaia Vilas-Zornoza, Patxi San Martin-Uriz, Laura Castro, Victoria Riego, Tamara Jimenez, Félix López Cadenas, Jesus M Hernández-Sánchez, Antonieta Molero, Julia Montoro, Bárbara Tazón, Bruno Paiva, María Díez-Campelo, David Valcarcel, David Lara-Astiaso, Felipe Prosper
Journal: Blood (2019)
Late Effects in Survivors of Infantile Acute Leukemia Are Less Severe Than Expected: A Study of the L.E.a Program
Authors: Virginie Gandemer, Jacinthe Bonneau, Caroline Oudin, Julie Berbis, Yves Bertrand, Marie-Dominique Tabone, Stephane Ducassou, Pascal Chastagner, Benoit Brethon, Jean-Hugues Dalle, Sandrine Thouvenin, Maryline Poiree, Dominique Plantaz, Justyna Kanold, Nicolas Sirvent, Patrick Lutz, Zeinab Hamidou, Andre Baruchel, Guy Leverger, Pascal Auquier, Gerard Michel
Journal: Blood (2016)
Changes in Tumor Immune Micro-Environment in Diffuse Large B-Cell Lymphoma (DLBCL): A Comparative Study of Relapsed Versus Diagnostic DLBCL
Authors: Raoul Santiago, Nathalie Johnson, Svetlana Dmitrienko, Andreas Papadakis, Naciba Benlimame, François Mercier, Koren Kathleen Mann, Sarit Assouline
Journal: Blood (2019)
Efficacy and Safety in 15 Hemophilia B Patients Treated with the AAV Gene Therapy Vector Fidanacogene Elaparvovec and Followed for at Least 1 Year
Authors: Lindsey A. George, Spencer K. Sullivan, John E.J. Rasko, Adam Giermasz, Benjamin J. Samelson-Jones, Jonathan M. Ducore, Jerome M. Teitel, Catherine E. McGuinn, Alexa R. Runowski, Fraser Wright, Xavier M. Anguela, Katherine A. High, Denis Rybin, John E. Murphy, Jeremy Rupon
Journal: Blood (2019)
Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report
Authors: Joseph F. Arboleda-Velasquez, Francisco Lopera, Michael O’Hare, Santiago Delgado-Tirado, Claudia Marino, Natalia Chmielewska, Kahira L. Saez-Torres, Dhanesh Amarnani, Aaron P. Schultz, Reisa A. Sperling, David Leyton-Cifuentes, Kewei Chen, Ana Baena, David Aguillon, Silvia Rios-Romenets, Margarita Giraldo, Edmarie Guzmán-Vélez, Daniel J. Norton, Enmanuelle Pardilla-Delgado, Arabiye Artola, Justin S. Sanchez, Juliana Acosta-Uribe, Matthew Lalli, Kenneth S. Kosik, Matthew J. Huentelman, Henrik Zetterberg, Kaj Blennow, Rebecca A. Reiman, Ji Luo, Yinghua Chen, Pradeep Thiyyagura, Yi Su, Gyungah R. Jun, Marcus Naymik, Xiaowu Gai, Moiz Bootwalla, Jianling Ji, Lishuang Shen, John B. Miller, Leo A. Kim, Pierre N. Tariot, Keith A. Johnson, Eric M. Reiman, Yakeel T. Quiroz
Journal: Nature Medicine (2019)
Specific Targeting of KRAS Using a Novel High-Affinity KRAS Antisense Oligonucleotide in Multiple Myeloma
Authors: Antonio Sacco, Cinzia Federico, Katia Todoerti, Bachisio Ziccheddu, Arianna Giacomini, Cosetta Ravelli, Federica Maccarinelli, Giada Bianchi, Angelo Belotti, Rossella Ribolla, Vanessa Favasuli, Alexey Revenko, A. Robert MacLeod, Brandon Willis, Hongoo Cai, Joana Hauser, Claire Rooney, Helen Ambrose, Anna Staniszewska, Lyndsey Hanson, Giuseppe Rossi, Roberto Ronca, Antonino Neri, Stefania Mitola, Niccolò Bolli, Marco Presta, Michele Moschetta, Sarah Ross, Aldo M. Roccaro
Journal: Blood (2019)
Layered double hydroxide eliminate embryotoxicity of chemotherapeutic drug through BMP-SMAD signaling pathway
Authors: Zhaojie Wang, Ziping Xu, Guoxin Jing, Qingxiu Wang, Li Yang, Xiaolie He, Lijuan Lin, Jintong Niu, Linnan Yang, Kun Li, Zhongmin Liu, Yechang Qian, Shilong Wang, Rongrong Zhu
Journal: Biomaterials (2019)
18F-PSMA 1007 Uptake in Brain Metastases From Breast Cancer
Authors: Fahad Marafi, Arun Sasikumar, Mahmoud Alfeeli, Wael Fathallah
Journal: Clinical Nuclear Medicine (2019)

A 64-year-old woman with metastatic breast cancer on follow-up had suspicious recurrent brain metastases. She underwent F-FDG PET/CT, F-PSMA 1007 brain PET/CT, and brain MRI. F-PSMA 1007 showed intense tracer localization in the suspected recurrent brain metastasis in right parietal lobe and also picked up 2 more metastatic brain lesions, which had concurrent findings of metastasis in subsequent MRI. Our case highlights the feasibility of F-PSMA 1007 PET/CT imaging of brain metastases from nonprostate cancers. It may be used as surrogate imaging tracer for potential theranostic application using alpha or beta emitters considering its similarity to PSMA-617.
Patterns of Renal Recovery and Toxicity with Novel Agent-Based Induction Triplets in Newly Diagnosed Multiple Myeloma - an Analysis of Two Prospective Studies By the German DSMM Myeloma Study Group
Authors: Friederike Bachmann, Swantje Held, Monika Engelhardt, Christian Langer, Denise Wolleschak, Janik Fleissner, Lars-Olof Mügge, Heinz Duerk, Martin Schreder, Kerstin Schaefer-Eckart, Igor-Wolfgang Blau, Martin Gramatzki, Peter Liebisch, Albrecht Reichle, Ivana Metzler, Florian Bassermann, Bernd Metzner, Christoph Röllig, Bernd Hertenstein, Tobias Dechow, Wolfram Jung, Helmut Ostermann, Holger Hebart, Georg Maschmeyer, Hans Jürgen Salwender, Marie von Lilienfeld-Toal, Kai-Uwe Eckardt, Christian Straka, Hermann Einsele, Stefan Knop
Journal: Blood (2019)