tbuckley/cabot-search huggingface dataset:
AB0127 Thyroid hormones in patients with ankylosing spondilitis or psoriatic arthritis
Authors: AT Kotulska, EJ Kucharz, J Go?dzik, D Kapo³ka, W Liwoch-Morzo³
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> Ankylosing spondylitis (AS) and psoriatic arthritis (PA) are diseases related to a group of arthritides known as seronegative spondyloarthropaties. Exraaarticular manifestations of SA or PS are a common feature. Thyroid gland involvement have been reported in almost all systemic rheumatic disorders. <h3>Objectives</h3> The present study was designed to evaluate serum thyroid hormones in patients with SA or PA. <h3>Methods</h3> Fourty patients (11F, 29M) aged 52.2 + 1.9 yrs with AS and 13 patients (4F, 9M) aged 46.4 + 11.2 yrs with PA as well as 10 healthy subjects (3F, 7M) aged 51.2 + 2.6 yrs were investigated. Serum thyroid hormones and thyrotropin levels were measured in all investigated individuals. <h3>Results</h3> A decrease in total triiodothyronine and total and free thyroxine was found in the AS patients. No changes in thyroid hormone levels were found in the PS patients. There was no correlation between the hormone levels, age, ESR and duration of symptoms, except negative correlation between free triiodothyronine and ESR in the controls (r = -0.5977), ESR and total triiodothyronine (r = -0.2160) and ESR and total thyroxine (r = 0.2321) in the AS patients. <h3>Conclusion</h3> From clinical point of view, thyroid involvement in AS or PA seems to be less important than in patients with other systemic rheumatic diseases.
WITHDRAWN: Reversible small-molecule polymerizable phosphatidylcholine: Novel disulfide crosslinked micelles for redox-dependent drug delivery
Authors: Longbing Ling, Muhammad Ismail, Xinsong Li
Journal: Acta Pharmaceutica Sinica B (2020)

This article has been withdrawn at the request of the author(s) due to authorship disputes. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.
Covid-19: Harshest restrictions are imposed on Greater Manchester after talks collapse
Authors: Elisabeth Mahase
Journal: BMJ (2020)

The harshest level of current restrictions (tier 3) is set to be imposed on Greater Manchester, England, after a struggle between local leaders and the government.On 20 October the prime minister, Boris Johnson, announced the restrictions, which will ban household mixing and close pubs and bars.More than 2000 cases of covid-19 were confirmed in Greater Manchester that day, and the area reported an infection rate of 399.4 in 100 000.
TCT CONNECT-488 Two-Year Outcomes of the TRI-REPAIR Study Assessing the Cardioband Tricuspid Valve Reconstruction System for Patients With Functional Tricuspid Regurgitation
Authors: Georg Nickenig, Marcel Weber, Jörg Hausleiter, Ralph Stephan von Bardeleben, Efthymios Sotiriou, Ulrich Schäfer, Florian Deuschl, Hannes Alessandrini, Felix Kreidel, Eric Brochet, Azeem Latib, Matteo Montorfano, Eustachio Agricola, Stephan Baldus, Kai Friedrichs, Rebecca Hahn, Francesco Maisano
Journal: Journal of the American College of Cardiology (2020)
TCT CONNECT-448 Management of Peri-Device Leak Following Left Atrial Appendage Closure: A Systematic Review
Authors: Jose Sleiman, Antonio Lewis, Eduardo Perez, Alexandra Sanchez, Diana Miranda, Hardik Bhansali, Nader Hanna, Yelenis Seijo De Armas, Nicholas Ghiloni, Kevin Leung, Luis Hernandez, Viviana Navas, Jose Baez-Escudero, Jose Navia, Craig Asher, Robert Cubeddu
Journal: Journal of the American College of Cardiology (2020)
Dual EGFR-VEGF Pathway Inhibition: A Promising Strategy for Patients With EGFR-Mutant NSCLC
Authors: Xiuning Le, Monique Nilsson, Jonathan Goldman, Martin Reck, Kazuhiko Nakagawa, Terafumi Kato, Luis Paz Ares, Bente Frimodt-Moller, Katharina Wolff, Carla Visseren-Grul, John V. Heymach, Edward B. Garon
Journal: Journal of Thoracic Oncology (2020)

The VEGF pathway has been recognized as a key mediator of angiogenesis to support tumorigenesis. Multiple therapeutic agents targeting VEGF and VEGF receptors have been developed and approved for use in NSCLCs. Preclinical studies have found that the VEGF and EGFR pathways share common downstream signaling, and these pathways can function exclusively of one another during oncogenesis. In EGFR-mutant NSCLCs, up-regulated EGFR signaling increases VEGF through hypoxia-independent mechanisms, and elevated VEGF, in turn, contributes to the emergence of resistance to EGFR tyrosine kinase inhibitors (TKIs). In clinical trials, the addition of anti-VEGF therapy to EGFR TKIs considerably improved clinical outcomes. In recently reported large randomized studies, the addition of bevacizumab or ramucirumab to EGFR TKIs substantially improved progression-free survival in patients with TKI-naive EGFR-mutant NSCLC. This article reviews the preclinical and clinical data supporting dual inhibition of EGFR and VEGF in EGFR-mutant NSCLC as a way to improve patient outcomes.
TCT CONNECT-331 The Baseline Characteristics of Successful MitraClip Procedure Assessed by CTA in Patients With Functional MR
Authors: Go Hashimoto, Bernardo Lopes, Miho Fukui, Maurice Sarano, Santiago Garcia, Mario Goessl, Paul Sorajja, John Lesser, Joao Cavalcante-Dupe
Journal: Journal of the American College of Cardiology (2020)
TCT CONNECT-357 Predictors of Inpatient Mortality After MitraClip in Contemporary Era
Authors: Ayush Arora, Sachin Kumar, Min Ji Kwak, Bindu Akkanti, Rahat Hussain, Sriram Nathan, Yelin Zhao, Prakash Balan, Abhjeet Dhoble, Ismael Salas De Armas, Jayeshkumar Patel, Biswajit Kar
Journal: Journal of the American College of Cardiology (2020)
2020 American Heart Association and American Red Cross Focused Update for First Aid
Authors: Jeffrey L. Pellegrino, Nathan P. Charlton, Jestin N. Carlson, Gustavo E. Flores, Craig A. Goolsby, Amber V. Hoover, Amy Kule, David J. Magid, Aaron M. Orkin, Eunice M. Singletary, Tammy M. Slater, Janel M. Swain
Journal: Circulation (2020)

additional treatment when needed, such as activating emergency medical services or seeking other medical assistance (emergency services). 1 The present document incorporates systematic reviews conducted by the First Aid Task Force of the International Liaison Committee on Resuscitation (ILCOR). 2 Systematic reviews and Consensus on Science With Treatment Recommendations (CoSTR) conducted by ILCOR provide upto-date science for international use.After formulation of the ILCOR systematic reviews and CoSTRs, a North American team with representatives appointed by the American Heart Association (AHA) and the American Red Cross (Red Cross) then applies the science within these documents to update existing first aid guidelines for use in curriculum and protocol development.Beginning in 2015, the ILCOR evidence evaluation process transitioned to a continuous evidence evaluation, with systematic reviews performed as new published evidence emerges or when an ILCOR task force prioritizes a topic.In 2020, the ILCOR First Aid Task Force conducted systematic reviews on the topics of recognizing stroke, providing supplemental oxygen for individuals suspected of stroke, when to offer aspirin for those with chest pain, methods of providing glucose for individuals suspected of hypoglycemia, means to stop life-threatening bleeding, use of compression wraps for the recovery from closed extremity joint injuries, mediums to store avulsed teeth, and cooling techniques for exertional hyperthermia or heatstroke.This focused update includes new and updated recommendations for first aid organizations and providers, but written for curriculum designer and educator use.Prior first aid guidelines should be consulted and will remain in place, unless updated, and are available
AB0043 THE IMBALANCE OF T FOLLICULAR REGULATORY CELL AND T FOLLICULAR HELPER CELL IN RHEUMATOID ARTHRITIS
Authors: R. Su, Y. Y. Wang, F. Y. Hu, X. Zheng, Y. Liu, X. Li, C. Wang
Journal: Annals of the Rheumatic Diseases (2020)

Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease which can lead to severe joint damage and disability.The relationship between antibodies and rheumatoid arthritis has long been well established. Recently, many studies have found that T follicular regulatory cells(Tfr) and T follicular helper cells (Tfh) are closely related to antibody generation on lymphoid follicular germinal centers (GCs) [1-2] . Tfr cells can inhibite the GC reaction and suppress production of high-affinity antibodies. The dysregulation of Tfh cells can lead to the production of autoantibodies by B cells. Objectives: To examine the expression of circulating T follicular regulatory cell (Tfr) and T follicular helper cell and its subsets(Tfh1 Tfh2 Tfh17) in RA patients and healthy control group. Methods: Level of Tfr and Tfh1,Tfh2 and Tfh17 cells in the peripheral blood of 17 new RA patients, 30 treated RA patients and 18 healthy controls were deceted by flow cytomery. All patients were hospitalised at the Department of Rheumatology, Second Hospital of Shanxi Medical University. Results: We found that the level of Tfr (CD3+CD4+CD25+CXCR5+FOP3+) percent(P=0.020), in the peripheral blood in RA patients were significantly decreased compared with healthy controls. The percent of Tfh (CD3+CD4+CXCR5+CD45RA-) ( P =0.039)and Tfh17 (CD3+CD4+CXCR5+CD45RA-CXCR3-CCR6+) ( P =0.000)were increased, but there are no statistical difference about Tfh1(CD3+CD4+CXCR5+CD45RA-CXCR3+CCR6-)( P =0.558) and Tfh2 (CD3+CD4+CXCR5+CD45RA-CXCR3-CCR6-) percent( P =0.079). We compared the above indicators between new and treated RA patients, and the results indicated that the Tfr( P= 0.013),Tfh ( P= 0.002) and Tfh1( P= 0.034) were significantly increased in the new RA patients compared to the treated RA patients, there were no differences between the two groups in Tfh2( P =0.419) and Tfh17 percent( P =0.124). Conclusion: Our results indicated that disorder of Tfr and Tfh subsets were involved in RA, restoring the Tfr/Tfh balance may be the potential therapeutic targets. Fig. 1. Comparison of Tfr, Tfh and its subsets(Tfh1 Tfh2 Tfh17) percent among the RA patients (n = 47) and healthy control group (n = 18) (*P &lt; 0.05). Fig. 2. Comparison of Tfr,Tfh and its subsets(Tfh1 Tfh2 Tfh17) percent among the new RA patients (n = 17) and treated RA patients(n = 30) (*P &lt; 0.05). References: [1]Deng J, Wei Y, Fonseca VR, Graca L, Yu D.T follicular helper cells and T follicular regulatory cells in rheumatic diseases[J].Nat Rev Rheumatol. 2019, 15(8):475-490. [2]Chen Liu, Dongwei Wang, Songsong Lu, et al.Increased Circulating Follicular Treg Cells Are Associated With Lower Levels of Autoantibodies in Patients With Rheumatoid Arthritis in Stable Remission.Arthritis Rheumatol. 2018, 70(5):711-721 Disclosure of Interests: None declared
Time in Range in Relation to All-Cause and Cardiovascular Mortality in Patients With Type 2 Diabetes: A Prospective Cohort Study
Authors: Jingyi Lu, Chunfang Wang, Yun Shen, Lei Chen, Lei Zhang, Jinghao Cai, Wei Lu, Wei Zhu, Gang Hu, Tian Xia, Jian Zhou
Journal: Diabetes Care (2020)

There is growing evidence linking time in range (TIR), an emerging metric for assessing glycemic control, to diabetes-related outcomes. We aimed to investigate the association between TIR and mortality in patients with type 2 diabetes.A total of 6,225 adult patients with type 2 diabetes were included from January 2005 to December 2015 from a single center in Shanghai, China. TIR was measured with continuous glucose monitoring at baseline, and the participants were stratified into four groups by TIR: >85%, 71-85%, 51-70%, and ≤50%. Cox proportional hazards regression models were used to estimate the association between different levels of TIR and the risks of all-cause and cardiovascular disease (CVD) mortality.The mean age of the participants was 61.7 years at baseline. During a median follow-up of 6.9 years, 838 deaths were identified, 287 of which were due to CVD. The multivariable-adjusted hazard ratios associated with different levels of TIR (>85% [reference group], 71-85%, 51-70%, and ≤50%) were 1.00, 1.23 (95% CI 0.98-1.55), 1.30 (95% CI 1.04-1.63), and 1.83 (95% CI 1.48-2.28) for all-cause mortality (P for trend <0.001) and 1.00, 1.35 (95% CI 0.90-2.04), 1.47 (95% CI 0.99-2.19), and 1.85 (95% CI 1.25-2.72) for CVD mortality (P for trend = 0.015), respectively.The current study indicated an association of lower TIR with an increased risk of all-cause and CVD mortality among patients with type 2 diabetes, supporting the validity of TIR as a surrogate marker of long-term adverse clinical outcomes.
Patient-Reported Outcomes of Robotic vs Laparoscopic Ventral Hernia Repair With Intraperitoneal Mesh
Authors: Clayton C. Petro, Sam Zolin, David Krpata, Hemasat Alkhatib, Chao Tu, Michael J. Rosen, Ajita S. Prabhu
Journal: JAMA Surgery (2020)

<h3>Importance</h3> Despite rapid adoption of the robotic platform for ventral hernia repair with intraperitoneal mesh in the United States, there is no level I evidence comparing it with the traditional laparoscopic approach. This randomized clinical trial sought to demonstrate a clinical benefit to the robotic approach. <h3>Objective</h3> To determine whether robotic approach to ventral hernia repair with intraperitoneal mesh would result in less postoperative pain. <h3>Design, Setting, and Participants</h3> A registry-based, single-blinded, prospective randomized clinical trial at the Cleveland Clinic Center for Abdominal Core Health, Cleveland, Ohio, completed between September 2017 and January 2020, with a minimum follow-up duration of 30 days. Two surgeons at 1 academic tertiary care hospital. Patients with primary or incisional midline ventral hernias of an anticipated width of 7 cm or less presenting in the elective setting and able to tolerate a minimally invasive repair. <h3>Interventions</h3> Patients were randomized to a standardized laparoscopic or robotic ventral hernia repair with fascial closure and intraperitoneal mesh. <h3>Main Outcomes and Measures</h3> The trial was powered to detect a 30% difference in the Numerical Rating Scale (NRS-11) on the first postoperative day. Secondary end points included the Patient-Reported Outcomes Measurement Information System Pain Intensity short form (3a), hernia-specific quality of life, operative time, wound morbidity, recurrence, length of stay, and cost. <h3>Results</h3> Seventy-five patients completed their minimally invasive hernia repair: 36 laparoscopic and 39 robotic. Baseline demographics and hernia characteristics were comparable. Robotic operations had a longer median operative time (146 vs 94 minutes;<i>P</i> &lt; .001). There were 2 visceral injuries in each cohort but no full-thickness enterotomies or unplanned reoperations. There were no significant differences in NRS-11 scores preoperatively or on postoperative days 0, 1, 7, or 30. Specifically, median NRS-11 scores on the first postoperative day were the same (5 vs 5;<i>P</i> = .61). Likewise, postoperative Patient-Reported Outcomes Measurement Information System 3a and hernia-specific quality-of-life scores, as well as length of stay and complication rates, were similar. The robotic platform adds cost (total cost ratio, 1.13 vs 0.97;<i>P</i> = .03), driven by the cost of additional operating room time (1.25 vs 0.85;<i>P</i> &lt; .001). <h3>Conclusions and Relevance</h3> Laparoscopic and robotic ventral hernia repair with intraperitoneal mesh have comparable outcomes. The increased operative time and proportional cost of the robotic approach are not offset by a measurable clinical benefit. <h3>Trial Registration</h3> ClinicalTrials.gov Identifier:NCT03283982
Peritoneal Spread of Ovarian Cancer Harbors Therapeutic Vulnerabilities Regulated by FOXM1 and EGFR/ERBB2 Signaling
Authors: Deepak Parashar, Bindu Nair, Anjali Geethadevi, Jasmine George, Ajay Nair, Shirng-Wern Tsaih, Ishaque P. Kadamberi, Gopa Kumar Gopinadhan Nair, Yiling Lu, Ramani Ramchandran, Denise S. Uyar, Janet S. Rader, Prahlad T. Ram, Gordon B. Mills, Sunila Pradeep, Pradeep Chaluvally-Raghavan
Journal: Cancer Research (2020)

Abstract Peritoneal spread is the primary mechanism of metastasis of ovarian cancer, and survival of ovarian cancer cells in the peritoneal cavity as nonadherent spheroids and their adherence to the mesothelium of distant organs lead to cancer progression, metastasis, and mortality. However, the mechanisms that govern this metastatic process in ovarian cancer cells remain poorly understood. In this study, we cultured ovarian cancer cell lines in adherent and nonadherent conditions in vitro and analyzed changes in mRNA and protein levels to identify mechanisms of tumor cell survival and proliferation in adherent and nonadherent cells. EGFR or ERBB2 upregulated ZEB1 in nonadherent cells, which caused resistance to cell death and increased tumor-initiating capacity. Conversely, Forkhead box M1 (FOXM1) was required for the induction of integrin β1, integrin-α V, and integrin-α 5 for adhesion of cancer cells. FOXM1 also upregulated ZEB1, which could act as a feedback inhibitor of FOXM1, and caused the transition of adherent cells to nonadherent cells. Strikingly, the combinatorial treatment with lapatinib [dual kinase inhibitor of EGFR (ERBB1) and ERBB2] and thiostrepton (FOXM1 inhibitor) reduced growth and peritoneal spread of ovarian cancer cells more effectively than either single-agent treatment in vivo. In conclusion, these results demonstrate that FOXM1 and EGFR/ERBB2 pathways are key points of vulnerability for therapy to disrupt peritoneal spread and adhesion of ovarian cancer cells. Significance: This study describes the mechanism exhibited by ovarian cancer cells required for adherent cell transition to nonadherent form during peritoneal spread and metastasis.
Nonalcoholic steatohepatitis: the role of peroxisome proliferator-activated receptors
Authors: Sven Francque, Gyongyi Szabo, Manal F. Abdelmalek, Christopher D. Byrne, Kenneth Cusi, Jean-François Dufour, Michael Roden, Frank Sacks, Frank Tacke
Journal: Nature Reviews Gastroenterology & Hepatology (2020)
THU0252 The prevalence of symptomatic knee and distal interphalangeal joint osteoarthritis in elderly urban population of antalya, turkey. a preliminary report
Authors: C Kaçar, B Bütün, C Yildirim, E Gilgil, G Sümbüloglu, I Tekeoglu, V Arikan, S Urhan, Ü Dündar, MC Öksüz, A Apaydin, T Tuncer
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> <h3>Objectives</h3> To estimate the prevalence of symptomatic knee and distal interphalangeal joint (DIP) osteoarthritis (OA) in the urban population of Antalya. <h3>Methods</h3> This cross-sectional study, as part of a continuing larger study, aimed to evaluate the prevalence of symptomatic knee and DIP OA in the elderly urban population of Antalya (508.840 population according to 1997 national census). By random cluster sampling based on the registries of local offices of the Ministry of Health, 267 individuals aged 50 or over (146 men, 121 women) were interviewed face to face by 10 physicians and 20 medical students trained for the study. The individuals were subjected to a questionnaire regarding knee pain, worsening pain on exertion and gelling phenomenon. They were also asked about their occupational status and performing namaz (an Islamic ritual based on bodily movements). If they reported any swelling in their hand joints, a physician simultaneously inspected the DIP joints for nodular swelling. In the case of suspicion for knee OA, individuals were invited to the hospital for further evaluation by physical examination and direct roentgenogram. <h3>Results</h3> Knee pain was reported in 38(28,4%) of men and 74(63,8%) of women. Of women, 64(57,1%) had worsened knee pain on exertion and 59(51,3%) defined gelling, and in men these figures were 26(20,5%) and 28(21,5%), respectively. The prevalence of knee osteoarthritis was determined as 26,4% in women and 6,2% in men (15,4% of total). The DIP OA was observed in 5(3,8%) of men and 30(26,3%) of women. <h3>Conclusion</h3> OA is a major health problem in the elderly population, especially in more than one fourth of the women aged 50 or over. This study is supported by the Akdeniz University Research Fund.
Tennis-specific extension of the International Olympic Committee consensus statement: methods for recording and reporting of epidemiological data on injury and illness in sport 2020
Authors: Evert Verhagen, Benjamin Clarsen, Jamie Capel-Davies, Christy Collins, Wayne Derman, Don de Winter, Nicky Dunn, Todd S Ellenbecker, Raymond Forde, Brian Hainline, Jo Larkin, Machar Reid, Per AFH Renstrom, Kathleen Stroia, Sue Wolstenholme, Babette M Pluim
Journal: British Journal of Sports Medicine (2020)

The IOC has proposed standard methods for recording and reporting of data for injury and illness in sport. The IOC consensus statement authors anticipated that sport-specific statements would provide further recommendations. This statement is the tennis-specific extension of the partner IOC statement. The International Tennis Federation Sport Science and Medicine Committee, in collaboration with selected external experts, met in June 2019 to consider athlete health monitoring issues specific to tennis. Once the IOC consensus statement was finalised, the tennis-specific consensus was drafted and agreed on by the members over three iterations. Compared with the IOC consensus statement, the tennis consensus contains tennis-specific information on injury mechanism, mode of onset, injury classification, injury duration, capturing and reporting exposure, reporting risk and study population. Our recommendations apply to able-bodied as well as wheelchair tennis players. Where applicable, specific recommendations are made for wheelchair tennis.
Acceptability, safety, and patterns of use of oral tenofovir disoproxil fumarate and emtricitabine for HIV pre-exposure prophylaxis in South African adolescents: an open-label single-arm phase 2 trial
Authors: Katherine Gill, Leigh Johnson, Janan Dietrich, Landon Myer, Rebecca Marcus, Melissa Wallace, Tanya Pidwell, Eve Mendel, Lauren Fynn, Kai Jones, Lubbe Wiesner, Catherine Slack, Ann Strode, Hans Spiegel, Sybil Hosek, James Rooney, Glenda Gray, Linda-Gail Bekker
Journal: The Lancet Child & Adolescent Health (2020)
CLIC1 recruits PIP5K1A/C to induce cell-matrix adhesions for tumor metastasis
Authors: Jei-Ming Peng, Sheng-Hsuan Lin, Ming-Chin Yu, Sen-Yung Hsieh
Journal: Journal of Clinical Investigation (2020)

Membrane protrusion and adhesion to the extracellular matrix, which involves the extension of actin filaments and formation of adhesion complexes, are the fundamental processes for cell migration, tumor invasion, and metastasis. How cancer cells efficiently coordinate these processes remains unclear. Here, we showed that membrane-targeted chloride intracellular channel 1 (CLIC1) spatiotemporally regulates the formation of cell-matrix adhesions and membrane protrusions through the recruitment of PIP5Ks to the plasma membrane. Comparative proteomics identified CLIC1 upregulated in human hepatocellular carcinoma (HCC) and associated with tumor invasiveness, metastasis, and poor prognosis. In response to migration-related stimuli, CLIC1 recruited PIP5K1A and PIP5K1C from the cytoplasm to the leading edge of the plasma membrane, where PIP5Ks generate a phosphatidylinositol 4,5-bisphosphate-rich (PIP2-rich) microdomain to induce the formation of integrin-mediated cell-matrix adhesions and the signaling for cytoskeleon extension. CLIC1 silencing inhibited the attachment of tumor cells to culture plates and the adherence and extravasation in the lung alveoli, resulting in suppressed lung metastasis in mice. This study reveals what we believe is an unrecognized mechanism that spatiotemporally coordinates the formation of both lamellipodium/invadopodia and nascent cell-matrix adhesions for directional migration and tumor invasion/metastasis. The unique traits of upregulation and membrane targeting of CLIC1 in cancer cells make it an excellent therapeutic target for tumor metastasis.