tbuckley/cabot-search huggingface dataset:
Targeting the Metabolic Response to Statin-Mediated Oxidative Stress Produces a Synergistic Antitumor Response
Authors: Grace H. McGregor, Andrew D. Campbell, Sigrid K. Fey, Sergey Tumanov, David Sumpton, Giovanny Rodriguez Blanco, Gillian Mackay, Colin Nixon, Alexei Vazquez, Owen J. Sansom, Jurre J. Kamphorst
Journal: Cancer Research (2019)

Abstract Statins are widely prescribed inhibitors of the mevalonate pathway, acting to lower systemic cholesterol levels. The mevalonate pathway is critical for tumorigenesis and is frequently upregulated in cancer. Nonetheless, reported effects of statins on tumor progression are ambiguous, making it unclear whether statins, alone or in combination, can be used for chemotherapy. Here, using advanced mass spectrometry and isotope tracing, we showed that statins only modestly affected cancer cholesterol homeostasis. Instead, they significantly reduced synthesis and levels of another downstream product, the mitochondrial electron carrier coenzyme Q, both in cultured cancer cells and tumors. This compromised oxidative phosphorylation, causing severe oxidative stress. To compensate, cancer cells upregulated antioxidant metabolic pathways, including reductive carboxylation, proline synthesis, and cystine import. Targeting cystine import with an xCT transporter–lowering MEK inhibitor, in combination with statins, caused profound tumor cell death. Thus, statin-induced ROS production in cancer cells can be exploited in a combinatorial regimen. Significance: Cancer cells induce specific metabolic pathways to alleviate the increased oxidative stress caused by statin treatment, and targeting one of these pathways synergizes with statins to produce a robust antitumor response. See related commentary by Cordes and Metallo, p. 151
TCT-77 Transcarotid Versus Subclavian/Axillary Access for Transcatheter Aortic Valve Replacement: Real-World Comparative Outcomes Utilizing the TVT Registry
Authors: James Hermiller, David Heimansohn, Sina Moainie, Eric Kirker, Ethan Korngold, Robert Hodson, Adnan Chhatriwalla, John Saxon, Keith Allen, Raymond McKay, Mohiuddin Cheema
Journal: Journal of the American College of Cardiology (2019)
TCT-803 Clinical Outcomes After TAVR in Patients With and Without Peripheral Arterial Disease: Results From the BRAVO-3 Randomized Trial
Authors: Robert Zilberszac, Rishi Chandiramani, Christian Hengstenberg, Samantha Sartori, Davide Cao, Jaya Chandrasekhar, Didier Tchetche, Roberto Violini, Raban Jeger, Eric Van Belle, Nicolas Dumonteil, Jurrien Ten Berg, Efthymios Deliargyris, Roxana Mehran, George Dangas
Journal: Journal of the American College of Cardiology (2019)
Response by Wu et al to Letter Regarding Article, “Glucose-Sensitive Myokine/Cardiokine MG53 Regulates Systemic Insulin Response and Metabolic Homeostasis”
Authors: Hong-Kun Wu, Yan Zhang, Gengjia Chen, Xinli Hu, Fengxiang Lv, Rui-Ping Xiao
Journal: Circulation (2019)
Correlates of distress for cancer patients: Results from multi-institution use of holistic patient-reported screening tool.
Authors: Christine B. Weldon, James I. Gerhart, Frank J. Penedo, Paramjeet Khosla, Betty Roggenkamp, Mary Pasquinelli, Joanna Martin, Teresa Lillis, Shelly S. Lo, Lawrence Eric Feldman, Catherine Deamant, Rosa Berardi, Harry Miranda, Carol Newsom, Anne Bowman, Julia Rachel Trosman
Journal: Journal of Clinical Oncology (2019)

11587 Background: The Commission on Cancer (CoC) Standard 3.2 requires distress screening and indicated action for cancer patients. NCCN and ASCO supportive care and age-related guidelines include patient reported concerns beyond distress. This study compares PHQ4 scores to other patient reported concerns. Methods: The Coleman Supportive Oncology Collaborative aggregated “best of” screening tools to assess patient reported needs and concerns aligned with CoC, NCCN and ASCO guidance. This supportive care screening tool was implemented at 8 sites from July 2015 thru July 2018. Analysis used chi squared test. Results: Most patients, 86% (10,635/12,295), reported one plus concerns and/or above threshold scores on PHQ4, PROMIS Pain, Fatigue or Physical Function. A chi squared comparison of patients with at least mild distress on PHQ4 to patients with no distress resulted in p values &lt; .0001 for every screening category. Conclusions: Patients with a PHQ4 distress score of mild, moderate or severe also reported statistically significant levels of practical, family, physical, nutrition and treatment concerns. These patients also scored threshold levels for PROMIS Pain, Fatigue, and Physical Function. Screening only for distress without screening for other patient concerns may direct patients to services that do not address or focus on the underlying cause of the distress. [Table: see text]
Stag2 regulates Hematopoietic Differentiation and Self-Renewal
Authors: Yotaro Ochi, Ayana Kon, Kenichi Yoshida, Keisuke Kataoka, Masahiro Marshall Nakagawa, Hideki Makishima, Manabu Nakayama, Haruhiko Koseki, Akifumi Takaori-Kondo, Seishi Ogawa
Journal: Blood (2017)
TCT-325 Quantitative Flow Ratio for Assessment of Nonculprit Coronary Lesions in Patients With ST-Segment Elevation Myocardial Infarction
Authors: Hidekuni Kirigaya, Kozo Okada, Kiyoshi Hibi, Eiichi Akiyama, Yasushi Matsuzawa, Noriaki Iwahashi, Nobuhiko Maejima, Masami Kosuge, Kazuo Kimura
Journal: Journal of the American College of Cardiology (2019)
Massage: Its Principles and Practice.
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TCT-642 PARIS Risk Score Stratified Analysis of Clinical Outcomes Among Elderly Patients (Aged &gt; 75 Years) Treated With 23-Month Ticagrelor Monotherapy Following 1-Month DAPT After PCI in the GLOBAL LEADERS Trial
Authors: Mariusz Tomaniak, Ply Chichareon, Rodrigo Modolo, Kuniaki Takahashi, Norihiro Kogame, Chun-Chin Chang, Ernest Spitzer, Robert-Jan Van Geuns, Tobias Geisler, Janusz Prokopczuk, Manel Sabate, Tessa Rademaker-Havinga, Christian Hamm, Yoshinobu Onuma, Pascal Vranckx, Marco Valgimigli, Stephan Windecker, Usman Baber, Richard Anderson, Marcello Dominici, Patrick Serruys
Journal: Journal of the American College of Cardiology (2019)
Extrinsic Upregulation of PD-L1 Induced by Pembrolizumab Combination Therapy in Patients with NSCLC with Low Tumor PD-L1 Expression
Authors: Kei Kunimasa, Harumi Nakamura, Kazumi Nishino, Shin-ichi Nakatsuka, Toru Kumagai
Journal: Journal of Thoracic Oncology (2019)
TCT-452 Septal Correction to Prevent Iatrogenic Left Ventricular Outflow Tract Obstruction (SCORPION) Prior to Transcatheter Mitral Valve Replacement
Authors: John Lisko, Norihiko Kamioka, Mikhael El Chami, Michael Lloyd, Jonathan Langberg, Samuel Maidman, Patrick Gleason, Kendra Grubb, Lucia Alvarez, Isida Byku, Chandan Devireddy, Jaffar Khan, Toby Rogers, Robert Guyton, Vasilis Babaliaros, Adam Greenbaum
Journal: Journal of the American College of Cardiology (2019)
The association between gut microbiota development and maturation of intestinal bile acid metabolism in the first 3 y of healthy Japanese infants
Authors: Masaru Tanaka, Masafumi Sanefuji, Seiichi Morokuma, Misako Yoden, Rie Momoda, Kenji Sonomoto, Masanobu Ogawa, Kiyoko Kato, Jiro Nakayama
Journal: Gut Microbes (2019)

The gut microbial community greatly changes in early life, influencing infant health and subsequent host physiology, notably through its collective metabolism, including host–microbiota interplay of bile acid (BA) metabolism. However, little is known regarding how the development of the intestinal microbial community is associated with maturation of intestinal BA metabolism. To address this, we monitored the succession of gut bacterial community and its association with fecal BA profile in the first 3 y of ten healthy Japanese infants. The BA profiles were classified into four types, defined by high content of conjugated primary BA (Con type), unconjugated primary BA (chenodeoxycholic acid and cholic acid) (Pri type), ursodeoxycholic acid (Urs type), and deoxycholic and lithocholic acid (Sec type). Most subjects begun with Con type or Pri type profiles during lactation and eventually transited to Sec type through Urs type after the start of solid food intake. Con type and Pri type were associated with Enterobacteriaceae-dominant microbiota corresponding to the neonatal type or Bifidobacterium-dominant microbiota corresponding to lactation type, respectively. Urs type subjects were strongly associated with Ruminococcus gnavus colonization, mostly occurring between Pri type and Sec type. Sec type was associated with adult-type complex microbiota dominated by a variety of Firmicutes and Bacteroidetes species. Addressing the link of the common developmental passage of intestinal BA metabolism with infant's health and subsequent host physiology requires further study.
Muscarinic acetylcholine receptor regulates self-renewal of early erythroid progenitors
Authors: Gaurang Trivedi, Daichi Inoue, Cynthia Chen, Lillian Bitner, Young Rock Chung, Justin Taylor, Mithat Gönen, Jürgen Wess, Omar Abdel-Wahab, Lingbo Zhang
Journal: Science Translational Medicine (2019)

The muscarinic acetylcholine receptor CHRM4 is a druggable target regulating the self-renewal of early erythroid progenitors.
TCT-498 Final Results of the Optimal Timing of Coronary Intervention in Unstable Angina-2 (OPTIMA-2) trial
Authors: Nick Fagel, Giovanni Amoroso, Ton Slagboom, Rene van der Schaaf, Maarten Vink, Jean-Paul Herrman, Freek Verheugt, Robert Riezebos
Journal: Journal of the American College of Cardiology (2019)
Efficacy of Neurohormonal Therapies in Preventing Cardiotoxicity in Patients With Cancer Undergoing Chemotherapy
Authors: Muthiah Vaduganathan, Sameer A. Hirji, Arman Qamar, Navkaranbir Bajaj, Ankur Gupta, Vlad G. Zaha, Alvin Chandra, Mark Haykowsky, Bonnie Ky, Javid Moslehi, Anju Nohria, Javed Butler, Ambarish Pandey
Journal: JACC CardioOncology (2019)

Various cardioprotective approaches have been evaluated to prevent chemotherapy-related cardiotoxicity; however, their overall utility remains uncertain.To assess the effects of neurohormonal therapies in preventing cardiotoxicity in patients receiving chemotherapy.This meta-analysis included randomized clinical trials of adult patients that underwent chemotherapy and neurohormonal therapies (beta-blockers, mineralocorticoid receptor antagonists, or ACE inhibitors/ARBs) vs. placebo with follow-up ≥4 weeks. The primary outcome was change in left ventricular ejection fraction (LVEF) from baseline to the end of trial. Other outcomes of interest were measures of LV size, strain, and diastolic function. Pooled estimates for each outcome were reported as standardized mean difference (SMD) and weighted mean difference (WMD) between the neurohormonal therapy and placebo groups using random effects models.We included 17 trials, collectively enrolling 1,984 participants. In pooled analysis, neurohormonal therapy (vs. placebo) was associated with significantly higher LVEF on follow-up [SMD(95% CI): +1.04(0.57 to 1.50)] but with significant heterogeneity in the pooled estimate (I2 = 96%). Compared with placebo-treated patients, those randomized to neurohormonal therapies experienced a 3.96% (95%CI: 2.9% to 5.0%) less decline in LVEF estimated by WMD, but with significant heterogeneity (I2 = 98%). There was a trend towards lower adverse clinical events with neurohormonal therapy (vs. placebo) without statistical significance [risk ratio(95%CI): 0.80(0.53-1.20) I2 = 71%].Neurohormonal therapies are associated with higher LVEF in follow-up among cancer patients receiving chemotherapy, although absolute changes in LVEF are small and may be within inter-test variability. Furthermore, significant heterogeneity is observed in the treatment effects across studies highlighting the need for larger trials of cardioprotective strategies.
Safety and efficacy of a self-expanding versus a balloon-expandable bioprosthesis for transcatheter aortic valve replacement in patients with symptomatic severe aortic stenosis: a randomised non-inferiority trial
Authors: Jonas Lanz, Won-Keun Kim, Thomas Walther, Christof Burgdorf, Helge Möllmann, Axel Linke, Simon Redwood, Christian Thilo, Michael Hilker, Michael Joner, Holger Thiele, Lars Conzelmann, Lenard Conradi, Sebastian Kerber, Gerhard Schymik, Bernard Prendergast, Oliver Husser, Stefan Stortecky, Dik Heg, Peter Jüni, Stephan Windecker, Thomas Pilgrim
Journal: The Lancet (2019)
British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults
Authors: Christopher Andrew Lamb, Nicholas A Kennedy, Tim Raine, Philip Anthony Hendy, Philip J Smith, Jimmy K Limdi, Bu’Hussain Hayee, Miranda C E Lomer, Gareth C Parkes, Christian Selinger, Kevin J Barrett, R Justin Davies, Cathy Bennett, Stuart Gittens, Malcolm G Dunlop, Omar Faiz, Aileen Fraser, Vikki Garrick, Paul D Johnston, Miles Parkes, Jeremy Sanderson, Helen Terry, Daniel R Gaya, Tariq H Iqbal, Stuart A Taylor, Melissa Smith, Matthew Brookes, Richard Hansen, A Barney Hawthorne
Journal: Gut (2019)

Ulcerative colitis and Crohn’s disease are the principal forms of inflammatory bowel disease. Both represent chronic inflammation of the gastrointestinal tract, which displays heterogeneity in inflammatory and symptomatic burden between patients and within individuals over time. Optimal management relies on understanding and tailoring evidence-based interventions by clinicians in partnership with patients. This guideline for management of inflammatory bowel disease in adults over 16 years of age was developed by Stakeholders representing UK physicians (British Society of Gastroenterology), surgeons (Association of Coloproctology of Great Britain and Ireland), specialist nurses (Royal College of Nursing), paediatricians (British Society of Paediatric Gastroenterology, Hepatology and Nutrition), dietitians (British Dietetic Association), radiologists (British Society of Gastrointestinal and Abdominal Radiology), general practitioners (Primary Care Society for Gastroenterology) and patients (Crohn’s and Colitis UK). A systematic review of 88 247 publications and a Delphi consensus process involving 81 multidisciplinary clinicians and patients was undertaken to develop 168 evidence- and expert opinion-based recommendations for pharmacological, non-pharmacological and surgical interventions, as well as optimal service delivery in the management of both ulcerative colitis and Crohn’s disease. Comprehensive up-to-date guidance is provided regarding indications for, initiation and monitoring of immunosuppressive therapies, nutrition interventions, pre-, peri- and postoperative management, as well as structure and function of the multidisciplinary team and integration between primary and secondary care. Twenty research priorities to inform future clinical management are presented, alongside objective measurement of priority importance, determined by 2379 electronic survey responses from individuals living with ulcerative colitis and Crohn’s disease, including patients, their families and friends.
Efficacy and Safety of Decitabine in Combination with G-CSF, Low-Dose Cytarabine and Mitoxantrone in Pediatric Refractory and Relapse Acute Myeloid Leukemia and MDS-Raebt
Authors: Liyan Fan, Aili Chen, Yixin Hu, Peifang Xiao, Jun Lu, Jie Li, Hailong He, Yi Wang, Shaoyan Hu
Journal: Blood (2018)
TCT-280 BIOFLOW-VI: BIOTRONIK—Safety and Clinical PerFormance of the Drug ELuting Orsiro Stent in the Treatment of Subjects With de novo Coronary Artery Lesions—VI: 2 Years Clinical Results
Authors: Yue Jin Yang, Biao Xu, Ron Waksman, Ye Zhu
Journal: Journal of the American College of Cardiology (2019)
Air pollution is linked to infant deaths and reduced lung function in children
Authors: Jacqui Wise
Journal: BMJ (2019)

Three air pollutants—nitrogen dioxide, particulate matter (PM10), and sulfur dioxide—separately and together are associated with an increased risk of infant deaths, according to a study of nearly eight million live births.1

A second study of nearly 14 000 children shows that exposure to air pollution from road traffic as early as the first trimester of pregnancy is associated with small but significant reductions in lung function at eight years.2

Both studies were presented at the European Respiratory Society International Congress in Madrid and have not yet been published or peer reviewed.

In the first study, funded by the UK Medical Research Council, researchers analysed data from 7 984 266 live births and deaths that occurred in England and Wales between 2001 and 2012. They divided the country into approximately 35 000 small areas each with a similar population size of 1500 residents. The areas were divided into quintiles according to their annual pollution exposure

The researchers adjusted …
TCT-843 Burden of 30 Days Readmission After PCI to Non-Index Hospital vs. Index-Hospital in the United States: Insights From the Nationwide Readmission Database (NRD)
Authors: Boutros Karam, Rabih Tabet, Wissam Mansour, Julie Zaidan, Youssef Shammaa, Jonathan Spagnola, Chadi Salmane, Farshid Daneshvar, Harout Yacoub, Armaghan Soomro, Frank Tamburrino, Ruben Kandov, James Lafferty
Journal: Journal of the American College of Cardiology (2019)
Activated stromal cells transfer mitochondria to rescue acute lymphoblastic leukemia cells from oxidative stress
Authors: Richard Burt, Aditi Dey, Sarah Aref, Melanie Aguiar, Ayse Akarca, Katharine Bailey, William Day, Steven Hooper, Amy Kirkwood, Kristina Kirschner, Soo-Wah Lee, Cristina Lo Celso, Jiten Manji, Marc R. Mansour, Teresa Marafioti, Rachel J. Mitchell, Robert C. Muirhead, Kenton Cheuk Yan Ng, Constandina Pospori, Ignazio Puccio, Krisztina Zuborne-Alapi, Erik Sahai, Adele K. Fielding
Journal: Blood (2019)
TCT-161 Association Between Platelet Aggregability During Primary Percutaneous Coronary Intervention and Increased Leukocyte in Patients With ST-Segment Elevation Myocardial Infarction
Authors: Shinnosuke Kikuchi, Kengo Tsukahara, Shinya Ichikawa, Eiichi Akiyama, Kozo Okada, Yasushi Matsuzawa, Nobuhiko Maejima, Noriaki Iwahashi, Kiyoshi Hibi, Masami Kosuge, Toshiaki Ebina, Kouichi Tamura, Kazuo Kimura
Journal: Journal of the American College of Cardiology (2019)
TCT-714 Aortic Lumen Area Modifies the Association Between Aortic Calcification and Mortality After Transcatheter Aortic Valve Replacement
Authors: Gautam Rangavajla, William Fearon, Sammy Elmariah, Juyong Kim, Linda Gillam, John Carr, Nishath Quader, Brian Whisenant, Samir Kapadia, Dharam Kumbhani, Anthony Bavry, Frederick Welt, Megan Coylewright, Shi Huang, Anna Vatterott, Natalie Jackson, Brian Lindman
Journal: Journal of the American College of Cardiology (2019)
Choosing Breast Cancer Risk Models: Importance of Independent Validation
Authors: Mitchel H Gail
Journal: JNCI Journal of the National Cancer Institute (2019)

Several widely used risk models estimate the chance that a woman will develop breast cancer over a defined time interval such as 5 years.Before using such a model, one should consider the nature of the target population and whether the model has been validated for that population.In this issue of the Journal, McCarthy and colleagues (1) present valuable data comparing the performance of five risk models in 35 921 predominantly white women who came to the Newton-Wellesley Hospital in Massachusetts for mammographic screens between 2007 and 2009.This study adds importantly to two other recent large validation studies.The UK Generation Study cohort (2) of 64 874 women was recruited between 2003 and 2012 from the general UK population.The Breast Cancer Prospective Family Study Cohort (3) (ProF-SC) included 15 732 women recruited from Australia, Canada, and the United States between 1992 and 2011 from high-risk clinics or as relatives of women in breast cancer registries.Of the women in ProF-SC, 82% had at least one affected first-degree relative, and 6.83% carried a mutation in BRCA1 or BRCA2 (4).These two general-population cohorts and one high-risk cohort enable assessment of risk model performance.Four widely used models incorporate a rare autosomal dominant genetic component: Claus ( 5), BRCAPRO (6), International Breast Cancer Intervention Study (IBIS) (or Tyrer-Cuzick) (7), and Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) (8).These models require detailed family history.IBIS and BOADICEA allow for residual familial correlation not explained by a rare autosomal dominant gene.IBIS also includes many standard breast cancer risk factors, and a recent version added mammographic density.Two other models assessed by McCarthy and colleagues do not assume an autosomal dominant component.The National Cancer Institute's Breast Cancer Risk Assessment Tool (BCRAT) (9,10), sometimes called the Gail model, requires only age, age at menarche, age at first live birth, number of previous benign breast biopsies, presence of atypical hyperplasia on biopsy, number of
Operator Experience and Outcomes of Transcatheter Mitral Valve Repair in the United States
Authors: Adnan K Chhatriwalla, Sreekanth Vemulapalli, Molly Szerlip, Susheel Kodali, Rebecca T Hahn, John T Saxon, Michael J Mack, Gorav Ailawadi, Jennifer Rymer, Pratik Manandhar, Andrzej S Kosinski, Paul Sorajja
Journal: Journal of the American College of Cardiology (2019)
TCT-370 Clinical Outcomes of Subjects With and Without Prior Gastrointestinal Bleeding in the Amplatzer Amulet Observational Study
Authors: Jacob Odenstedt, Sven Fischer, Boris Schmidt, Sergio Berti, Patrizio Mazzone, Paolo Della Bella, Ignacio Cruz-Gonzalez, Zbigniew Kalarus, Heyder Omran, Volker Schulze, Tobias Zeus, Volker Geist, Dhiraj Gupta
Journal: Journal of the American College of Cardiology (2019)
TCT-725 Comparative Study of the Hemodynamic Performance of Two Latest Generation Supra-Annular Self-Expanding Transcatheter Aortic Valves (Allegra Versus ACURATE neo)
Authors: Ariana Gonzálvez-García, Harol Hernandez, Alfonso Jurado-Román, Guillermo Galeote, Jimenez Valero Santiago, Laura Rodriguez, Irene Marco Clement, Adrián Rivas-Pérez, Rosa González-Davia, Ignacio Plaza, Raul Moreno, Jose Lopez Sendon
Journal: Journal of the American College of Cardiology (2019)
TCT-256 Minimally Invasive Transradial Approach for Percutaneous Closure of Aortic Paravalvular Leaks: A Single-Center Experience
Authors: Luis Ortega-Paz, Ander Regueiro, Salvatore Brugaletta, Laura Sanchis, Juan Manuel Perdomo, Monica Masotti-Centol, Manel Sabate, Xavier Freixa
Journal: Journal of the American College of Cardiology (2019)