OP0310-HPR METABOLIC ABNORMALITIES IN MEXICAN PATIENTS WITH RHEUMATIC DISEASES
Authors: C. M. Gamboa-Alonso, J. D. Ángulo, R. E. Díaz-García, G. Figueroa-Parra, D. Á. Galarza-Delgado, J. C. Riegatorres
Journal: Annals of the Rheumatic Diseases (2020)

Background: Nutritional status plays an essential role in the etiopathogenesis of rheumatic diseases either as a triggering factor or as a contributor in the progression of disease activity, comorbidities and ineffective therapeutic response. 1 An increased Body Mass Index (BMI) and a low lean muscle mass (LMM) have been associated to a worse clinical prognosis in rheumatic diseases. 1 Objectives: To describe the nutritional status and alterations in a cohort of patients with rheumatic diseases. Methods: 658 mexican rheumatic patients from a rheumatology public center were included. Anthropometrical measurements were assessed using bio-electrical impedance analysis (BIA) Tanita. including weight, height, BMI, Body Fat Percentage and Body Fat Mass (FM), Visceral Fat (VF), MM, Total Body Water (TBW) and Bone Mass (BM) which were classified according to validated parameters as normal and abnormal. Results: A total of 658 patients were evaluated, 368 (55.92%) had Rheumatoid Arthritis. Table 1. The different diagnosis and anthropometric measures for each pathology are listed in Graphic 1. Tabel 1. Bioelectric impedance and anthropometric results in Rheumatic diseases RA LES OA FM EA SS SSc N 368 106 69 38 32 24 21 Female 335 (91) 98 (92.5) 63 (91.3) 38 (100) 19 (59.4) 23 (95.8) 21 (100) Hight 1.56 (0.07) 1.58 (0.07) 1.56 (0.09) 1.57 (0.06) 1.62 (0.1) 1.57 (0.06) 1.57 (0.06) Age 51.71 (12.29) 37.61 (12.57) 58.67 (10.27) 48 (11.43) 44.1 (14.93) 55.79 (12.90) 48.33 (9.51) Weight (kg) 70.02(14.94) 69.1 (16.77) 70.34 (16.63) 71.82 (12.56) 71.43 (16.55) 70.82 (15.53) 62.9 (18.18) Total fat (%) 35.99 (8.60) 32.78 (10.43) 37.11 (7.70) 38.06 (6.48) 30.38 (12.4) 38.02 (9.09) 31.98 (8.68) Total fat (kg) 26.06 (10.81) 24.41 (12.31) 27.13 (11.16) 28.08 (9.47) 22.97 (12.56) 28.12 (12.12) 21.28 (10.52) Total body water (%) 44.71 (6.06) 47.41 (7.41) 43.45 (4.31) 43.21 (3.82) 49.59 (10.47) 42.99 (5.74) 46.87 (4.99) Visceral fat 8.69 (3.68) 6.33 (4.37) 9.71 (3.90) 8.32 (3.06) 8.28 (4.85) 9.21 (4.32) 7.27 (4.19) Lean mass (%) 60.75 (8.18) 63.71 (9.98) 59.67 (7.75) 58.82 (6.14) 65.98 (11.77) 58.47 (9.21) 66.3 (11.38) Lean mass (kg) 41.68 (6.13) 42.86 (6.70) 41.14 (6.98) 41.54 (3.48) 45.92 (8.74) 40.11 (4.74) 40.13 (6.92) Bone mass 2.38 (0.79) 2.69 (1.40) 2.64 (2.42) 2.32 (0.5) 2.79 (1.19) 2.14 (0.21) 2.48 (1.16) BMI 28.69 (6.15) 27.79 (6.52) 28.72 (5.5) 29.36 (5.19) 27.41 (6.55) 28.6 (5.98) 25.58 (7.40) RA: Rheumatoid arthritis, SLE: Systemic Lupus Erythematosus, OA: Osteoarthritis, FM: Fibromyalgia, EA: Spondyloarthropaties, SS: Sjogren Syndrome, SSc: Scleroderma More than half of the patients (68.05%) presented an increased BMI and 85.56% a decreased MM. Graphic 2. Conclusion: This study showed that sarcopenic obesity, defined as low MM with an increased BMI 1 , is a common disorder among rheumatic patients, found in more than half of our studied population. Since nutrition is a modifiable factor, important investigation in the detection and approach of metabolic abnormalities should be done. References: [1]Stavropoulos-Kalinoglou, A., Metsios, G. S., Panoulas, V. F., Nevill, A. M., Jamurtas, A. Z., Koutedakis, Y., &amp; Kitas, G. D. (2009). Underweight and obese states both associate with worse disease activity and physical function in patients with established rheumatoid arthritis. Clinical rheumatology , 28 (4), 439-444. Graphic 1. RA: Rheumatoid Arthritis, LES: Systemic Lupus erythematosus, OA: Osteoarthritis, FM: Fibromyalgia, EA: Spondyloarthropaties, SS: Sjögren’s Syndrome, SSc: Scleroderma. A BMI &gt;25 kg/m2 was classified as overweight and &gt; 30 kg/m2 obesity, BFM &gt;35% in women and 24% in men was classified as high,as well as VF &gt;12%; a low LMM was &lt;68% in women and &lt;75% in men, BM &lt;2.4 was considered low. Graphic 2. Metabolic abnormalities in rheumatic diseases. BMI= Body Mass Index; BFM= Body Fat Mass; VF = Visceral Fat; LMM = Lean Muscle Mass; BM= Bone Mass Disclosure of Interests: None declared