tbuckley/cabot-search huggingface dataset:
Improving Value in Health Care Through Comprehensive Supply Optimization
Authors: Cassandra Thiel, Leora I. Horwitz
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LKB1 Deficiency Renders NSCLC Cells Sensitive to ERK Inhibitors
Authors: Elisa Caiola, Alice Iezzi, Michele Tomanelli, Elisa Bonaldi, Arianna Scagliotti, Marika Colombo, Federica Guffanti, Edoardo Micotti, Marina Chiara Garassino, Lucia Minoli, Eugenio Scanziani, Massimo Broggini, Mirko Marabese
Journal: Journal of Thoracic Oncology (2019)
Abstract 493: Multidirectional Analysis of Anti-atherosclerotic Effect Caused by Korean Radish in Apo E–/– Mice Model
Authors: Jinhyuk Na, Adnan Khan, Kyung-A Hwang, Youngja H Park
Journal: Circulation Research (2019)

Atherosclerosis, a leading cause of worldwide mortality and morbidity, is mainly controlled with statins, however, the statins have severe side effects like rhabdomyolysis. In search of an alternative for statin, we investigated anti-atherosclerotic and anti-hyperlipidemic effects of two different species of Raphanus sativus Linn (also known as radish), Jeju (white radish) and Ganghwa (purple radish) cultivated in South Korea. An atherosclerosis model in ApoE knockout mice was firstly established with high fat diet, followed by feeding the mice with extracts of each radish. Concentration of plasma lipids and histological changes were evaluated. Metabolomics analysis of urine was determined to see the effect of radish. Ganghwa-radish treated mice were observed with significantly decreased levels of total cholesterol, low-density lipoprotein, triglyceride, atherogenic index and cardiac risk factor while high-density lipoprotein was significantly increased. Steroid biosynthesis and steroid hormone biosynthesis were although significantly altered metabolic pathways among both radish treated groups, however, significant changes in these pathways were mainly observed with the treatment of Ganghwa-radish. Crucially, estrogens, estrone and estradiol, were significantly decreased in Ganghwa-radish treated group compared to control. In conclusion, we confirmed the prominent antilipidemic effect of Ganghwa-radish compared with Jeju-radish and such results might be due to the inhibition of estrogens by Ganghwa-radish treatment.
Inotuzumab Ozogamicin Compassionate Use for French Pediatric Patients with Relapsed or Refractory Acute Lymphoblastic Leukemia
Authors: Charlotte Calvo, Benoit Brethon, Aurelie Cabannes-Hamy, Dalila Adjaoud, Benedicte Bruno, Laurence Blanc, Nicolas Boissel, Marie-Dominique Tabone, Andre Baruchel
Journal: Blood (2018)
Improving quality through A.I.: Applying machine learning to predict unplanned hospitalizations after radiation.
Authors: Kaitlin M. Christopherson, Christopher G. Berlind, Christopher A. Ahern, Angela Holmes, William David Lindsay, Benjamin D. Smith, Prajnan Das, Grace L. Smith
Journal: Journal of Clinical Oncology (2019)

271 Background: Unplanned hospitalizations may diminish quality of care among cancer patients receiving radiotherapy (RT). In patients undergoing RT for gastrointestinal (GI) cancers, we hypothesized that a machine learning approach would enable prediction of unplanned hospitalizations within 30 days of RT. Methods: We analyzed 836 abdominal (gastric, pancreatic, biliary, hepatic) and 514 pelvic (rectal, anal) courses of RT for GI cancers treated at our institution (3/2016—1/2019). Over 700 clinical/treatment variables and unplanned hospitalizations during or within 30 days after RT were mined from institutional databases. Using machine learning, we developed random forest (RF), gradient boosted decision trees (XGB), and logistic models for unplanned hospitalizations. Models were trained on 670 abdominal and 423 pelvic cases. Five-fold cross-validation (CV) was used to select model type and hyperparameters, using area under the ROC curve (AUC) to measure performance. The best model was validated on the subsequent 166 abdominal and 91 pelvic cases. AUC&gt;0.70 was deemed clinically valid. Results: Among 1,350 cases, incidence of 30-day unplanned hospitalization was 12.3% (13.3% abdominal cohort; 10.7% pelvic cohort). Model CV AUCs are shown in table. The best models were XGB and RF for the abdominal and pelvic cohorts, respectively. Their validation testing AUCs are shown in table. For all models tested, lab values (e.g. potassium, lipoproteins, hemoglobin) prior to RT were significant predictors of unplanned hospitalizations. In the abdominal cohort, pancreatic primary and total RT dose were important. For the pelvic cohort, body mass index was important. Median healthcare costs from RT start - 30 days post-RT were $69,108 in non-hospitalized patients and $119,844 in hospitalized patients. Conclusions: In GI cancer patients undergoing RT, a machine learning model identified patients at risk of 30-day unplanned hospitalization. Predictive analytics may be a key tool to help providers identify high-risk patients and optimize interventions, while improving quality and value of care. [Table: see text]
Abstract 500: Progression of Chronic Ischemia-Mediated Arrhythmogenesis in a Rat Model of Heart Failure
Authors: Ike R Chinyere, Jordan J Lancaster, Jen Watson Koevary, Sherry Daugherty, Steven Goldman, Elizabeth Juneman
Journal: Circulation Research (2019)

Background: Worldwide, the prevalence of heart failure (HF) is increasing and HF patients are living longer. Chronic ischemic HF presents with increased vulnerability to ventricular tachycardia and fibrillation. However, the mechanism of these arrhythmias differ between the acute infarction phase and the chronic, namely via myocyte membrane potential instability in the acute phase versus substrate-mediated reentry in the chronic phase. We propose our chronic heart failure (CHF) model to recapitulate the potentially progressive nature of arrhythmogenesis in the chronic phase. Methods: Adult male Sprague Dawley rats underwent permanent left coronary artery ligation and were maintained for six or ten weeks; SHAM operations were also performed. At each respective endpoint, SHAM and CHF rats underwent transthoracic echocardiography and invasive hemodynamic evaluation. Finally, a median sternotomy was performed for epicardial electrophysiology (EP) assessment. Programmed electrical stimulation was utilized to assess susceptibility to induced ventricular tachycardia (VT) and also to determine effective refractory period (ERP). Results: Six-week CHF (n=50) induction proved successful as evidenced by the decrease in left ventricular ejection fraction (LVEF) (76±3% to 35±2%, p&lt;0.0001) and the increase in left ventricular end-diastolic pressure (LVEDP) (6±1 mmHg to 20±2 mmHg, p=0.0008) compared to SHAM (n=15). Progression to ten-week CHF (n=18) also proved successful via LVEF and LVEDP maintenance (35±2% to 38±3%, p=0.3909) (20±2 mmHg to 15±3 mmHg, p=0.1578). EP studies revealed an increase in the incidence of induced VT between SHAM and six-week CHF (0% to 60%, p&lt;0.0001) and a prolongation of the ERP (54±4 milliseconds to 69±3 ms, p=0.0228). The incidence of induced VT and ERP did not continue to increase between six- and ten-week CHF (60% to 50%, p=0.5804), (69±3 ms to 68±3 ms, p=0.8221). Conclusion: Myocardial infarction-mediated arrhythmogenesis is known to exist in an acute and a chronic phase. Here, we examine the chronic phase of ischemic HF and show evidence to support that once the adverse remodeling-mediated substrate stabilizes, proarrhythmic deterioration ceases.
Hepatitis C Virus Infection, but Not Hepatic Iron Overload Is the Dominant Risk Factor for the Manifestation of Hepatocellular Carcinoma Among Greek Thalassemic Patients
Authors: Alexandra Kourakli, Michael D. Diamantidis, Myrto-Evangelia Skafidas, Sophia Delicou, Despoina Pantelidou, Christina Fragodimitri, Efthymia Vlachaki, Stylianos Lafioniatis, Fotini Petropoulou, Eftychios Eftychiadis, Eleni Kapsali, Anastasia Kalpaka, Christos Zissis, Frideriki Koutsouka, Artemis Vasileiadi, Anastasia Goula, Panagiota Giasari, Marianna Katsatou, Ioannis Lafiatis, Evangelos Klironomos, Panagiotis Kaiafas, Dimitra Kyriacopoulou, Vasileios Lazaris, Konstantinos Maragkos, Paraskevi Fotiou, Panagiota Chalkia, Vasiliki Schiza, Antonis Kattamis, Argiris Symeonidis
Journal: Blood (2018)
Efficient CRISPR/Cas9-Mediated Gene Editing of Pklr in Human Hematopoietic Progenitors and Stem Cells for the Gene Therapy of Pyruvate Kinase Deficiency
Authors: Oscar Quintana Bustamante, Sara Fañanas-Baquero, Daniel P. Dever, Alberquilla Omaira, Joab Camarena, Rebeca Sanchez-Dominguez, Matias Morin, Val Fernandez, Miguel Angel Moreno-Pelayo, Juan A. Bueren, Matthew Porteus, Jose C Segovia
Journal: Blood (2018)
Expression of the ULBP Ligands for NKG2D by B-NHL Cells Plays An Important Role in Determining Their Susceptibility to Rituximab-Induced ADCC
Authors: Atsushi Inagaki, Takashi Ishida, Hiroki Yano, Fumiko Mori, Asahi Ito, Masaki Ri, Jianmin Ding, Shigeru Kusumoto, Hirokazu Komatsu, Shinsuke Iida, Ryuzo Ueda
Journal: Blood (2008)
Contribution of Flow Cytometry Immunophenotyping in Diagnostic of Acute and Chronic Leukemias
Authors: Aldair Sousa Paiva, Hugo Diogenes De Oliveira Paiva, Geraldo Barroso Cavalcanti, Lenilton Silva Silveira, Lorena KF Silva, Erica Aires Gil, Roberto C Vasconcelos, Frank Bahia, Rodrigo Villar Freitas, Dany GKC Silva, Valéria SF Sales, Alessandra Suelen Jardim, Victor lima Soares, James Farley Marciel
Journal: Blood (2018)
The Minimal Epo Receptor Allele, EpoR-H, Regulates ERK1,2, (But Not JNKs or p70S6K), and Induces Pim-1, SOCS3 and Oncostatin-M (But Not BcL-XL) in Primary Erythroblasts.
Authors: Madhu P. Menon, Bethany Cuetara, Estelle Houde, Jing Fang, Olga Bogacheva, Oleg Bogachev, Vinit Karur, Melanie Ufkin, Don Wojchowski
Journal: Blood (2005)
Reduced Toxicity Conditioning with Treosulfan and Fludarabine in Allogeneic Hematopoietic Stem Cell Transplantation for Myelodysplastic Syndromes: Results of an International Prospective Phase II Trial.
Authors: Tapani Ruutu, Liisa Volin, Dietrich W. Beelen, Rudolf Trenschel, Juergen Finke, Marc Schnitzler, Jerzy Holowiecki, Sebastian Giebel, Lutz Uharek, I. Wolfgang Blau, Matthias Stelljes, Joachim Kienast, Kajsa Larsson, Axel R. Zander, Martin Gramatzki, Roland Repp, Hermann Einsele, Gernot Stuhler, Mathias Freund, Jochen Casper
Journal: Blood (2008)
Gender differences in grant and personnel award funding rates at the Canadian Institutes of Health Research based on research content area: A retrospective analysis
Authors: Karen E. A. Burns, Sharon E. Straus, Kuan Liu, Leena Rizvi, Gordon Guyatt
Journal: PLoS Medicine (2019)

Although women at all career stages are more likely to leave academia than men, early-career women are a particularly high-risk group. Research supports that women are less likely than men to receive research funding; however, whether funding success rates vary based on research content is unknown. We addressed gender differences in funding success rates for applications directed to one or more of 13 institutes, representing research communities, over a 15-year period.We retrospectively reviewed 55,700 grant and 4,087 personnel award applications submitted to the Canadian Institutes of Health Research. We analyzed application success rates according to gender and the primary institute selected by applicants, pooled gender differences in success rates using random effects models, and fitted Poisson regression models to assess the effects of gender, time, and institute. We noted variable success rates among grant applications directed to selected institutes and declining success rates over time. Women submitted 31.1% and 44.7% of grant and personnel award applications, respectively. In the pooled estimate, women had significantly lower grant success (risk ratio [RR] 0.89, 95% confidence interval [CI] 0.84-0.94; p < 0.001; absolute difference 3.2%) compared with men, with substantial heterogeneity (I2 = 58%). Compared with men, women who directed grants to the Institutes of Cancer Research (RR 0.86, 95% CI 0.78-0.96), Circulatory and Respiratory Health (RR 0.74, 95% CI 0.66-0.84), Health Services and Policy Research (RR 0.78, 95% CI 0.68-0.90), and Musculoskeletal Health and Arthritis (RR 0.80, 95% CI 0.69-0.93) were significantly less likely to be funded, and those who directed grants to the Institute of Aboriginal People's Health (RR 1.67, 95% CI 1.0-2.7) were more likely to be funded. Overall, women also had significantly lower personnel award success (RR 0.75, 95% CI 0.65-0.86; p < 0.001; absolute difference 6.6%). Regression modelling identified that the effect of gender on grant success rates differed by institute and not time. Study limitations include use of institutes as a surrogate identifier, variability in designation of primary institute, and lack of access to metrics reflecting applicants, coapplicants, peer reviewers, and the peer-review process.Gender disparity existed overall in grant and personnel award success rates, especially for grants directed to selected research communities. Funding agencies should monitor for gender differences in grant success rates overall and by research content.
Treatment with 8F4, An Anti-PR1/HLA-A2 T Cell Receptor-Like Antibody, Reduces Established Acute Myeloid Leukemia and Eliminates Leukemia Stem Cells in Mice
Authors: Anna Sergeeva, Hong He, Kathryn Ruisaard, Karen Clise-Dwyer, Lisa S St. John, Rebecca Patenia, Pariya Sukhumalchandra, Gheath Alatrash, William K Decker, Elizabeth J Shpall, M. James You, Qing Ma, Jeffrey J. Molldrem
Journal: Blood (2011)
Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin
Authors: Espen Melum, Xiaojun Jiang, Kristi D. Baker, M. Fatima Macedo, Jürgen Fritsch, C. Marie Dowds, Jing Wang, Anne Pharo, Arthur Kaser, Corey Tan, Catia S. Pereira, Samuel L. Kelly, Jingjing Duan, Tom H. Karlsen, Mark A. Exley, Stefan Schütze, Dirk M. Zajonc, Alfred H. Merrill, Edward H. Schuchman, Sebastian Zeissig, Richard S. Blumberg
Journal: Nature Immunology (2019)
The Important but Rarely Studied Cascade of Care
Authors: John Mandrola, Daniel J. Morgan
Journal: JAMA Network Open (2019)

Ishani Ganguli, MD, MPH; Arabella L. Simpkin, MD, MMSc; Claire Lupo, BBA; Arlene Weissman, PhD; Alexander J. Mainor, JD, MPH; E. John Orav, PhD; Meredith B. Rosenthal, PhD; Carrie H. Colla, PhD; Thomas D. Sequist, MD, MPH
Submucosal Saline Injection Followed by Endoscopic Ultrasound versus Endoscopic Ultrasound Only for Distinguishing between T1a and T1b Esophageal Cancer
Authors: Long-Jun He, Chuanbo Xie, Zi-Xian Wang, Yin Li, Yi-Tai Xiao, Xiao-Yan Gao, Hong-Bo Shan, Lin-Na Luo, Li-Ming Chen, Guang-Yu Luo, Ping Yang, Shuo-Chun Zeng, Guo-Liang Xu, Jian-Jun Li
Journal: Clinical Cancer Research (2019)

Abstract Purpose: To examine whether submucosal saline injection (SSI) can improve traditional endoscopic ultrasound (EUS) accuracy in distinguishing between T1a and T1b stage esophageal squamous cell carcinoma (ESCC). Experimental Design: Patients with T1N0M0 stage ESCC (n = 180) ages 18 to 85 years were enrolled between February 14, 2012 to June 4, 2018 at Sun Yat-sen University Cancer Center (Guangdong, China). They were randomly assigned (1:1) to receive either EUS examination after 3–5 mL SSI or EUS only examination. All the patients were referred to thoracic surgeons to receive endoscopic resection (ER) or esophagectomy 5 to 10 days after EUS examination. Standard EUS criteria were used to preoperatively stage the ESCC cases, and surgical pathology reports after referral were used to postoperatively stage the cases. The primary endpoint was the diagnostic accuracy of T1b staging [defined as the sum of the true positive (T1b) and true negative (T1a) cases divided by the total number of cases]. Results: Among the per-protocol population, the SSI+EUS group (n = 81) was superior to the EUS-only group (n = 85) in terms of the diagnostic accuracy for T1b staging [93.8% (95% confidence interval (CI), 88.6–99.1) vs. 65.9% (95% CI, 55.8–76.0); P &amp;lt; 0.001]. The positive predictive value of SSI+EUS for diagnosing T1b ESCC reached 90.9% (95% CI, 81.1–100), which was significantly superior to that of EUS only [0.576 (0.450-0.702), P = 0.001]. Conclusions: SSI significantly improves the diagnostic accuracy of EUS in distinguishing between T1a and T1b ESCC, which might help avoid unnecessary esophagectomy and diagnostic ER.
Building Capacity for Relapsed/Refractory ALL Patients Needing CAR-T Cells: How Do We Prepare?
Authors: Roy Khalife, Joshua Montroy, Wasithep Limvorapitak, Raewyn Broady, Dean Fergusson, Harold Atkins, Robert Holt, Manoj Lalu, Natasha Kekre
Journal: Blood (2018)
Smoldering Multiple Myeloma: Usefulness of Serum Heavy/Light Chain Measurements for the Evaluation of Evolving Pattern
Authors: Carlos Fernandez de Larrea, Ignacio Isola, Esther Moga, Maria Teresa Cibeira, Ester Lozano, Juan I. Arostegui, Montserrat Elena, Natalia Tovar, Jordi Yague, Laura Rosinol, Joan Bladé
Journal: Blood (2018)
Adaptive disinhibitory gating by VIP interneurons permits associative learning
Authors: Sabine Krabbe, Enrica Paradiso, Simon d’Aquin, Yael Bitterman, Julien Courtin, Chun Xu, Keisuke Yonehara, Milica Markovic, Christian Müller, Tobias Eichlisberger, Jan Gründemann, Francesco Ferraguti, Andreas Lüthi
Journal: Nature Neuroscience (2019)
Abstract 732: Attenuation of Tnf-α Induced Injury in Cardiomyocytes by Chlorogenic Acid via Inhibiting Nf-κB and Jnk Signals
Authors: Shuzhen Guo, Lei Tian, Cong Ping Su, Qing Wang, Fu Jian Wu, Rui Bai, Hui Min Zhang, Jin Ying Liu, Wen Jing Lu, Wei Wang, Feng Lan
Journal: Circulation Research (2019)

The traditional Chinese herb Lonicerae Japonicae Flos has been used to treat various diseases including heart failure, showing significant benefits in the clinical practice. However, the mechanism of its cardioprotective effects remains unclear. As the main active ingredient found in the plasma after oral administration of Lonicerae Japonicae Flos , chlorogenic acid (CGA) has been reported to possess anti-inflammatory, anti-oxidant, anti-apoptosis and analgesic function. To investigate whether the cardioprotective effects of Lonicerae Japonicae Flos is through CGA, we applied Transverse Aortic Constriction (TAC)-induced heart failure mouse model, to access the effects of CGA. The results of in vivo experiments show that CGA has cardioprotective effects and could mitigate the TNF-α(Tumor necrosis factor-alpha) induced toxicity in TAC heart failure mouse model. Therefore, we further used TNF-α-induced cardiac injury in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to explore whether CGA have cardioprotective effects and elucidate the underlying mechanism(s). CGA pretreatment could reverse TNF-α induced cellular injuries, including improved cell viability, increased mitochondrial membrane potential and inhibited cardiomyocytes apoptosis. We then examined the NF-κB/p65 and major MAPKs signaling pathways involved in TNF-α induced apoptosis of hiPSC-CMs. Importantly, both CGA and NF-κB inhibitor (QNZ) can reverse the cell viability impairment and apoptosis phenotypes. Moreover CGA can directly inhibit NF-κB signal by suppressing the phosphorylation of NF-κB/p65. As for the MAPKs, CGA suppressed the activity of JNK only, but enhanced ERK1/2 and had no effect on p38. In summary, our study revealed that CGA has profound cardioprotective effects through inhibiting the activation of NF-κB and JNK pathway, providing a novel therapeutic alternative for prevention and treatment of heart failure.
Deregulated Expression of Long Noncoding RNAs H19, LEF1-AS1, TCL6, and WT1-AS1 Predicts Poor Outcome of Patients with Myelodysplastic Syndromes
Authors: Michaela Dostalova Merkerova, Nikoleta Loudova, Katarina Szikszai, Zdenek Krejcik, Jiri Klema, Pavla Pecherkova, Andrea Hrustincova, Jitka Vesela, Jaroslav Cermak, Anna Jonasova, Monika Belickova
Journal: Blood (2018)
Jak-2 and Nfkbia Gene Expression Play a Strategic Role in Chronic Myeloid Leukemia (CML) Molecular Response during Early Nilotinib Treatment: The PhilosoPhi34 Data
Authors: Ester Pungolino, Mariella D'adda, Alessandra Trojani, Alessandra Perego, Chiara Elena, Alessandra Iurlo, Simona Malato, Mauro Turrini, Gabriella De Canal, Lorenza Borin, Milena Lodola, Marianna Caramella, Salvatore Artale, Francesco Spina, Maria Luisa Latargia, Michela Anghilieri, Pierangelo Spedini, Mariacristina Carraro, Barbara Di Camillo, Doriana Gramegna, Maria Luisa Pioltelli, Giuseppe Rossi, Enrica Morra, Roberto Cairoli
Journal: Blood (2018)
Haploinsufficiency for NR3C1 Drives Glucocorticoid Resistance By Inactivation the PI3K/AKT/GSK3β/Bim Pathway in Adult Acute Lymphoblastic Leukemia
Authors: Xiao Haowen, Yingying Ding, Yang Gao, Limengmeng Wang, Huafang Wang, Xiaohong Yu, He Huang
Journal: Blood (2018)
Bone Marrow T Cell Subpopulations in Patients with Newly Diagnosed B-Cell Precursor Acute Lymphoblastic Leukemia (ALL).
Authors: Peter Brinkrolf, Silke Landmeier, Bianca Altvater, Sibylle Pscherer, Annegret Rosemann, Heribert Juergens, Andreas Ranft, Claudia Rossig
Journal: Blood (2007)
Abstract 504: AAV9-Mediated Overexpression of TRPM4 Increases the Incidence of Ventricular Arrhythmias in Living Mice
Authors: Andy Pironet, Frone Vandewiele, Ninda Syam, Greetje Vande Velde, Rik Gijsbers, Rudi Vennekens
Journal: Circulation Research (2019)

Cardiac conduction disorders are a common cause of lethal cardiac arrhythmias and can be caused by mutations in ion channels. Several studies suggest that mutations in the Transient Receptor Potential subfamily M member 4 (TRPM4) are responsible for hereditary forms of cardiac conduction disorders. The majority of mutations that are described in TRPM4 lead to gain-of-function of channel activity. Analysis of the first identified gain-of-function mutation, p.E7K in a cellular overexpression system suggests that attenuated deSUMOylation of the protein, leads to impaired endocytosis and consequently an increase in the number of functional channels in the plasma membrane. To test the idea that an increased number of TRPM4 channels leads to cardiac arrhythmias, we created a functional overexpression model of the TRPM4 channel in living mice. To this end, we overexpressed TRPM4 in mice using adeno-associated virus serotype 9 (AAV9) particles, which has been described as the most cardiotropic of AAV serotypes. Overexpression of TRPM4 was achieved via tail vein injection of AAV9 particles. Subsequently, we performed telemetric ECG-measurements in freely-moving mice to determine their in vivo cardiac phenotype. In baseline conditions, the heart rate and ECG-parameters were similar between TRPM4-overexpressing and WT mice. Additionally, the number of arrhythmic incidents in resting mice was not different between TRPM4-overexpressing mice and WT mice. Instead, WT mice overexpressing TRPM4 exhibited more premature ventricular ectopic beats during exercise-induces β-adrenergic stress. Conduction abnormalities were rare and was not increased in mice overexpressing TRPM4. Taken together, mice overexpressing TRPM4 were more prone to develop premature ventricular ectopic beats during exercise-induced β-adrenergic stress.