Update in Hematology and Oncology: Evidence Published in 2015
Authors: Alice D. Ma, Harold J. Burstein
Journal: Annals of Internal Medicine (2016)

Updates3 May 2016Update in Hematology and Oncology: Evidence Published in 2015Alice D. Ma, MD and Harold J. Burstein, MD, PhDAlice D. Ma, MDFrom the University of North Carolina, Chapel Hill, North Carolina, and Dana-Farber Cancer Institute, Boston, Massachusetts.Search for more papers by this author and Harold J. Burstein, MD, PhDFrom the University of North Carolina, Chapel Hill, North Carolina, and Dana-Farber Cancer Institute, Boston, Massachusetts.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M16-0214 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail This update reviews articles on benign and malignant hematology and medical oncology that were published in 2015 and had a marked impact. In hematology, patients receiving warfarin for atrial fibrillation who were undergoing elective surgery did not benefit from bridging therapy with low-molecular-weight heparin. In patients with a first unprovoked venous thromboembolism (VTE), computed tomography (CT) did not identify new diagnoses of cancer. A targeted reversal agent for the direct oral anticoagulant idarucizumab was described. Multiple new drugs were either approved or showed activity in various types of hematologic cancer, adding to the growing repertoire of treatments.In oncology, antibody ...References1. Ribas A. Releasing the brakes on cancer immunotherapy. N Engl J Med. 2015;373:1490-2. [PMID: 26348216] doi:10.1056/NEJMp1510079 CrossrefMedlineGoogle Scholar2. Postow MA, Chesney J, Pavlick AC, Robert C, Grossmann K, McDermott D, et al. Nivolumab and ipilimumab versus ipilimumab in untreated melanoma. N Engl J Med. 2015;372:2006-17. [PMID: 25891304] doi:10.1056/NEJMoa1414428 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From the University of North Carolina, Chapel Hill, North Carolina, and Dana-Farber Cancer Institute, Boston, Massachusetts.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M16-0214.Editors' Disclosures: Christine Laine, MD, MPH, Editor in Chief, reports that she has no financial relationships or interests to disclose. Darren B. Taichman, MD, PhD, Executive Deputy Editor, reports that he has no financial relationships or interests to disclose. Cynthia D. Mulrow, MD, MSc, Senior Deputy Editor, reports that she has no relationships or interests to disclose. Deborah Cotton, MD, MPH, Deputy Editor, reports that she has no financial relationships or interest to disclose. Jaya K. Rao, MD, MHS, Deputy Editor, reports that she has stock holdings/options in Eli Lilly and Pfizer. Sankey V. Williams, MD, Deputy Editor, reports that he has no financial relationships or interests to disclose. Catharine B. Stack, PhD, MS, Deputy Editor for Statistics, reports that she has stock holdings in Pfizer.Corresponding Author: Alice Ma, MD, Division of Hematology/Oncology, University of North Carolina, 170 Manning Drive, CB #7305, Chapel Hill, NC 27599.Current Author Addresses: Dr. Ma: Division of Hematology/Oncology, University of North Carolina, 170 Manning Drive, CB #7305, Chapel Hill, NC 27599.Dr. Burstein: Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115.Author Contributions: Conception and design: H. Burstein.Analysis and interpretation of the data: H. Burstein.Drafting of the article: A. Ma, H. Burstein.Critical revision of the article for important intellectual content: A. Ma, H. Burstein.Final approval of the article: A. Ma, H. Burstein. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 3 May 2016Volume 164, Issue 9Page: W32-W36KeywordsAtrial fibrillationBreast cancerCancer screeningChemotherapyComputed axial tomographyHematology and oncologyHemorrhageLung and intrathoracic tumorsMelanomaMutation ePublished: 3 May 2016 Issue Published: 3 May 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...