tbuckley/cabot-search huggingface dataset:
Polypectomies multiples à l'anse froide dans les polyposes adénomateuses coliques
Authors: M Dhooge, S Leblanc, M Barret, B Bordacahar, F Maksimovic, F Prat, B Brieau, S Chaussade
Journal: Endoscopy (2019)

La technique de polypectomie colique à l'anse froide s'est récemment largement répandue et fait maintenant partie des recommandations de bonnes pratiques de la société européenne de gastroentérologie (ESGE) pour l'exérèse des polypes coliques infra centimétriques. Cette technique est facile d'utilisation, présente un taux de complication très faible (2) ainsi qu'un taux d'exérèse R0 élevé (3). Jusqu'à présent seules les techniques d'exérèse à la pince, de destruction à l'argon ou de mucosectomie étaient utilisées chez les patients présentant des tableaux de polypose adénomateuse colique, opérées ou non, conduisant parfois à poser des indications de chirurgie prophylactique faute de méthode efficiente de cytoréduction. Nous présentons ici des données de faisabilité et de tolérance de polypectomies multiples du tube digestif bas à l'anse froide chez des patients pris en charge pour polypose adénomateuse colique.
Publisher Correction: Landscape of B cell immunity and related immune evasion in human cancers
Authors: Xihao Hu, Jian Zhang, Jin Wang, Jingxin Fu, Taiwen Li, Xiaoqi Zheng, Binbin Wang, Shengqing Gu, Peng Jiang, Jingyu Fan, Xiaomin Ying, Jing Zhang, Michael C. Carroll, Kai W. Wucherpfennig, Nir Hacohen, Fan Zhang, Peng Zhang, Jun S. Liu, Bo Li, X. Shirley Liu
Journal: Nature Genetics (2019)
High-Flow Oxygen Therapy for Respiratory Failure in Immunocompromised Patients—Reply
Authors: Elie Azoulay, Sylvie Chevret, Alexandre Demoule
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Off-the-Shelf Bioengineered Blood Vessels Tested in Trials
Authors: Jennifer Abbasi
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnostic endoscopique du Helicobacter pylori dans une population européenne
Authors: R Garcés Duran, A García-Rodríguez, H Córdova, A Ginès, B González-Suárez, I Araujo, J Llach, G Fernández-Esparrach
Journal: Endoscopy (2019)

L'infection par Helicobacter pylori (Hp) est une des principales causes de gastrite chronique et de lésions pré malignes gastriques
Allogeneic hematopoietic stem cell transplantation from unrelated donors is associated with higher infection rates in children with acute lymphoblastic leukemia—A prospective international multicenter trial on behalf of the BFM‐SG and the EBMT‐PDWP
Authors: Herbert Pichler, Anita Lawitschka, Evgenia Glogova, Andre M. Willasch, Irene von Luettichau, Thomas Lehrnbecher, Susanne Matthes‐Martin, Peter Lang, Peter Bader, Karl W. Sykora, Johanna Schrum, Bernhard Kremens, Karoline Ehlert, Michael H. Albert, Michaela Kuhlen, Roland Meisel, Tayfun Guengoer, Brigitte Strahm, Bernd Gruhn, Ansgar Schulz, Wilhelm Woessmann, Ulrike Poetschger, Christina Peters
Journal: American Journal of Hematology (2019)

Severe infections (SI) significantly impact on non-relapse mortality after hematopoietic stem cell transplantation (HSCT). We assessed 432 children and adolescents with acute lymphoblastic leukemia (ALL) after total body irradiation based myeloablative HSCT within the multicenter ALL-BFM-SCT 2003 trial for SI grade 3 or higher according to common terminology criteria for adverse events. A total 172 patients experienced at least one SI. Transplantation from matched unrelated donors (MUD) was associated with any type of SI in the pre-engraftment period (hazard ratio [HR]: 2.57; P < .001), and with any SI between day +30 and + 100 (HR: 2.91; P = .011). Bacterial (HR: 2.24; P = .041) and fungal infections (HR: 4.06; P = .057) occurred more often in the pre-engraftment phase and viral infections more often before day +30 (HR: 2.66; P = .007) or between day +30 and + 100 (HR: 3.89; P = .002) after HSCT from MUD as compared to matched sibling donors. Chronic GvHD was an independent risk factor for any type of SI after day +100 (HR: 2.57; P < .002). We conclude that allogeneic HSCT from MUD in children and adolescents with pediatric ALL is associated with higher infection rates, which seems attributable to an intensified GvHD prophylaxis including serotherapy and methotrexate.
COMPARISON OF TWO DIFFERENT CLEANSING PROTOCOLS FOR SMALL BOWEL CAPSULE ENDOSCOPY
Authors: C Carretero, C Prieto de Frias, M Olcoz, A Bojorquez, M Munoz-Navas
Journal: Endoscopy (2019)

ESGE recently published a technical review on capsule endoscopy, where the recommendation is to use cleansing protocols before small bowel capsule endoscopy. Nevertheless, the optimal timing for taking purgatives is yet to be established.
Minimal-Invasive Robot-Assisted Image-Guided Resection of Prostate-Specific Membrane Antigen–Positive Lymph Nodes in Recurrent Prostate Cancer
Authors: Fijs W. B. van Leeuwen, Matthias N. van Oosterom, Philippa Meershoek, Pim J. van Leeuwen, Christoph Berliner, Henk G. van der Poel, Markus Graefen, Tobias Maurer
Journal: Clinical Nuclear Medicine (2019)

Abstract With the rapid expansion of robot-assisted surgical procedures, the need for robot-compliant image guidance technologies has also increased. Examples hereof are the integrated firefly fluorescence camera, the drop-in ultrasound probe, and the recently introduced DROP-IN gamma probe. Combined with 68 Ga–prostate-specific membrane antigen–(PSMA)–11 PET/CT (staging) and 99m Tc-PSMA-I&amp;S SPECT/CT (preoperative imaging), the latter DROP-IN gamma probe technology recently allowed us to perform the first clinical cases of robot-assisted PSMA-guided salvage surgery of lymphatic metastases.
GP at Hand: CCG is forced to delay primary care network approvals after single network request
Authors: Gareth Iacobucci
Journal: BMJ (2019)

The clinical commissioning group (CCG) hosting Babylon Health’s GP at Hand service has been forced to delay approving local practices’ applications to join primary care networks, after referring the digital service’s bid to become a single network1 to NHS England.

GP leaders said it was vital that delays did not extend beyond the 30 June deadline, as this could prevent practices from accessing much needed additional funding for patient care through the network contract directed enhanced service (DES), which starts on 1 July.

To qualify for the extra funding, practices had to submit an application by 15 May to register to join a collaborative network covering 30 000-50 000 patients. CCGs had to ensure that all patients in their locality area will be covered by a network by 31 May 2019.

But Hammersmith and Fulham CCG’s primary care committee said at a meeting …
EUS-DIRECTED TRANS-JEJUNO-GASTRIC BYPASS ERCPS WITH USE OF 20MM LUMEN-APPOSING METAL STENTS (LAMS) IN A PATIENT WITH ROUX-EN-Y GASTRIC BYPASS (RYGB) DUE TO REFRACTORY BILIARY LEAK
Authors: R Sanchez-Ocaña, A Yaiza Carbajo, J Tejedor, M De Benito, J García-Alonso, S Bazaga, C De la Serna Higuera, M Pérez-Miranda
Journal: Endoscopy (2019)

EUS-guided gastrogastromy with LAMS between pouch and gastric remnant of the RYGB gain acceptance to practice ERCP. LAMS migration during the passage of the duodenoscope occurs up to 60%. Deferred ERCP until maturation of the fistula is advised. New 20-mm LAMS have a 25% larger diameter, and could facilitate ERCP, but have not been tested on RYGB yet.
BEYOND PALLIATION: USING EUS-GUIDED CHOLEDOCHODUODENOSTOMY WITH A LUMEN-APPOSING METAL STENT AS A BRIDGE TO SURGERY
Authors: C Fabbri, A Fugazza, C Binda, A Zerbi, E Jovine, V Cennamo, A Repici, A Anderloni
Journal: Endoscopy (2019)

We analyzed the efficacy of pylorus-preserving pancreaticoduodenectomy (PPPD) after endoscopic ultrasonography-guided choledochoduodenostomy (EUS-CD) using a lumen-apposing metal stent (LAMS) as a bridge to surgery.
SMALL COLORECTAL POLYPS: IS A SYSTEMATIC HISTOPATHOLOGICAL ASSESSMENT JUSTIFIED?
Authors: H Jlassi, D Trad, K Lassoued, M Sabbah, N Bibani, H Elloumi, A Ouakaa, D Gargouri
Journal: Endoscopy (2019)

Small polyps constitute the vast majority of colorectal polyps. The prevalence of advanced adenomas in this group of lesions is low. The "Detect-and-leave" strategy is discussed for diminutive polyps (≤5 mm), given the induced costs and the high proportion of non adenomatous lesions. The aim of this study is to determine the histopathological nature of resected diminutive (≤5 mm) colorectal polyps and to evaluate the interest of a systematic histopathological assessment.
Epithelial ovarian cancer: Evolution of management in the era of precision medicine
Authors: Stephanie Lheureux, Marsela Braunstein, Amit M. Oza
Journal: CA A Cancer Journal for Clinicians (2019)

Abstract Ovarian cancer is the second most common cause of gynecologic cancer death in women around the world. The outcomes are complicated, because the disease is often diagnosed late and composed of several subtypes with distinct biological and molecular properties (even within the same histological subtype), and there is inconsistency in availability of and access to treatment. Upfront treatment largely relies on debulking surgery to no residual disease and platinum‐based chemotherapy, with the addition of antiangiogenic agents in patients who have suboptimally debulked and stage IV disease. Major improvement in maintenance therapy has been seen by incorporating inhibitors against poly (ADP‐ribose) polymerase (PARP) molecules involved in the DNA damage‐repair process, which have been approved in a recurrent setting and recently in a first‐line setting among women with BRCA1 / BRCA2 mutations. In recognizing the challenges facing the treatment of ovarian cancer, current investigations are enlaced with deep molecular and cellular profiling. To improve survival in this aggressive disease, access to appropriate evidence‐based care is requisite. In concert, realizing individualized precision medicine will require prioritizing clinical trials of innovative treatments and refining predictive biomarkers that will enable selection of patients who would benefit from chemotherapy, targeted agents, or immunotherapy. Together, a coordinated and structured approach will accelerate significant clinical and academic advancements in ovarian cancer and meaningfully change the paradigm of care.
Sixty seconds on . . . mandatory vaccination
Authors: Nigel Hawkes
Journal: BMJ (2019)

So the UK has long believed. Respect for individual autonomy and the need for informed consent have always trumped compulsion in British vaccination policy.

Yes. Fewer than 2% of parents refuse all vaccinations.

A new analysis by an Italian team warns that unless stronger action is taken to increase the rate of measles vaccination, the susceptible fraction of …
Neglecting the “second victim” will not help harmed patients or improve patient safety
Authors: Esperanza L Gómez-Durán, G Tolchinsky, C Martin-Fumadó, J Arimany-Manso
Journal: BMJ (2019)

Clarkson and colleagues call for abandoning the term “second victim,”1 but its introduction was good for all parties.2 It may have increased the attention given to the phenomenon, but it should in no way minimise the tragedies of patients harmed by medical errors. Patient centred care is central to the mission of healthcare professionals, who are committed to helping patients—even more so when things go wrong.

The wellbeing of healthcare professionals is crucial for a safe healthcare system and is central to patient care.3 Helping and caring for others can …
Management of Myocarditis-Related Cardiomyopathy in Adults
Authors: Carsten Tschöpe, Leslie T. Cooper, Guillermo Torre-Amione, Sophie Van Linthout
Journal: Circulation Research (2019)

Myocarditis is generally a mild and self-limited consequence of systemic infection of cardiotropic viruses. However, patients can develop a temporary or permanent impairment of cardiac function including acute cardiomyopathy with hemodynamic compromise or severe arrhythmias. In this setting, specific causes of inflammation are associated with variable risks of death and transplantation. Recent translational studies suggest that treatments tailored to specific causes of myocarditis may impact clinical outcomes when added to guideline-directed medical care. This review summarizes recent advances in translational research that influence the utility of endomyocardial biopsy for the management of inflammatory cardiomyopathies. Emerging therapies for myocarditis based on these mechanistic hypotheses are entering clinical trials and may add to the benefits of established heart failure treatment.
ENDOSCOPIC TREATMENT OF INTRAMURAL FISTULA E MUCOSAL TEAR OCCURRED AFTER PERORAL ENDOSCOPIC MYOTOMY (POEM)
Authors: P Familiari, R Landi, F Mangiola, F D'Aversa, F Borrelli De Andreis, A Costantini, V Bove, I Boskoski, A Tringali, V Perri, G Costamagna
Journal: Endoscopy (2019)

POEM is a safe procedure for the treatment of esophageal motility disorders. A correct closure of the esophageal mucosal incision (mucosotomy) and the integrity of the mucosal flap are crucial for the safety of the procedure, in order to prevent esophageal leakages and infections.
Dangers of Opioid Prescribing for Young Adults After Dental Procedures—Reply
Authors: Alan R. Schroeder, Thomas B. Newman, K. T. Park
Journal: JAMA Internal Medicine (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Macrophage Smad3 Protects the Infarcted Heart, Stimulating Phagocytosis and Regulating Inflammation
Authors: Bijun Chen, Shuaibo Huang, Ya Su, Yi-Jin Wu, Anis Hanna, Adipong Brickshawana, Jonathan Graff, Nikolaos G. Frangogiannis
Journal: Circulation Research (2019)

Rationale: TGF (transforming growth factor)-β is critically involved in myocardial injury, repair, and fibrosis, activating both Smad (small mothers against decapentaplegic)-dependent and non-Smad pathways. The in vivo role of TGF-β signaling in regulation of macrophage function is poorly understood. We hypothesized that in the infarcted myocardium, activation of TGF-β/Smad signaling in macrophages may regulate repair and remodeling. Objective: To investigate the role of macrophage-specific TGF-β Smad3 signaling in a mouse model of myocardial infarction and to dissect the mechanisms mediating Smad-dependent modulation of macrophage function. Methods and Results: TGF-βs markedly activated Smad3 in macrophages, without affecting Smad-independent pathways. Phagocytosis rapidly and directly activated macrophage Smad3, in the absence of active TGF-β release. MyS3KO (myeloid cell–specific Smad3 knockout) mice had no baseline defects but exhibited increased late mortality and accentuated dilative postmyocardial infarction remodeling. Adverse outcome in infarcted MyS3KO mice was associated with perturbations in phagocytic activity, defective transition of macrophages to an anti-inflammatory phenotype, scar expansion, and accentuated apoptosis of border zone cardiomyocytes. In vitro, Smad3 null macrophages exhibited reduced expression of genes associated with eat-me signals, such as Mfge8 (milk fat globule-epidermal growth factor factor 8), and reduced capacity to produce the anti-inflammatory mediators IL (interleukin)-10 and TGF-β1, and the angiogenic growth factor VEGF (vascular endothelial growth factor). Mfge8 partly rescued the phagocytic defect of Smad3 null macrophages, without affecting inflammatory activity. Impaired anti-inflammatory actions of Smad3 null macrophages were associated with marked attenuation of phagocytosis-induced PPAR (peroxisome proliferator-activated receptor) expression. MyS3KO mice had no significant alterations in microvascular density and interstitial fibrosis in remodeling myocardial segments. Conclusions: We demonstrate that Smad3 critically regulates function of infarct macrophages, by mediating acquisition of a phagocytic phenotype and by contributing to anti-inflammatory transition. Smad3-dependent actions in macrophages protect the infarcted heart from adverse remodeling.
Abstract P240: Eating Behavior and Body Composition in Chilean Young Adults: Results From the Santiago Longitudinal Study
Authors: Lorena S Pacheco, Estela Blanco, Raquel Burrows, Paulina Correa-Burrows, Jose L Santos, Sheila Gahagan
Journal: Circulation (2018)

Introduction: Causes of obesity, a leading risk factor for chronic disease morbidity/mortality, are multi-faceted and encompass behavioral and psychological factors. Understanding eating behavior can help target behavioral obesity interventions. The aim of this cross-sectional study was to examine cognitive restraint (CR), uncontrolled eating (UE) and emotional eating (EE) behaviors and body composition in a sample of Chilean young adults. Methods: Using data from 429 participants of the Santiago Longitudinal Study (mean age 22.5±0.4 years), evaluated from 2016-2017, linear and logistic regression models assessed the independent associations between three eating behavior dimensions, using the Three Factor Eating Questionnaire (1-4 range per dimension), and BMI, % body fat (measured by dual-energy x-ray absorptiometry), and central obesity, accounting for demographic covariates, stratified by sex. Results: The sample was 51% female and had a mean BMI of 26.9±6.1. Mean % body fat was 30.5±7.6 in males and 41.8±6.9 in females. CR and EE eating behaviors were associated with body composition measures as shown in the Table 1. CR was related to a 2.4 (95% CI 1.2, 4.8) and 2.5 (95% CI 1.4, 4.5), respectively, greater odds of being an obese male (&gt;25% body fat) and obese female (&gt;37% body fat). The EE dimension was also significantly associated with percent body fat in both sexes. The greatest effect size in the linear regression models was observed for central obesity. For every point increase in CR, waist circumference increased by 5.1 cm (95% CI 2.1-8.1) and 4.1 cm (95% CI 1.5-6.7) in males and females, respectively. EE was positively associated with central obesity in females. Conclusions: In this sample of Chilean young adults, CR and EE eating behavior dimensions were associated with obesity, central obesity and% body fat. The UE dimension was not associated with body composition. Understanding the dynamics of and interplay of eating behaviors and body composition can provide evidence for future effective interventions.
Circulating Gut Microbiota Metabolite Trimethylamine N-Oxide (TMAO) and Changes in Bone Density in Response to Weight Loss Diets: The POUNDS Lost Trial
Authors: Tao Zhou, Yoriko Heianza, Yuhang Chen, Xiang Li, Dianjianyi Sun, Joseph A. DiDonato, Xiaofang Pei, Meryl S. LeBoff, George A. Bray, Frank M. Sacks, Lu Qi
Journal: Diabetes Care (2019)

OBJECTIVE Type 2 diabetes is related to obesity and altered bone health, and both are affected by gut microbiota. We examined associations of weight loss diet–induced changes in a gut microbiota–related metabolite trimethylamine N-oxide (TMAO), and its precursors (choline and l-carnitine), with changes in bone mineral density (BMD) considering diabetes-related factors. RESEARCH DESIGN AND METHODS In the 2-year Preventing Overweight Using Novel Dietary Strategies trial (POUNDS Lost), 264 overweight and obese participants with measurement of BMD by DXA scan were included in the present analysis. The participants were randomly assigned to one of four diets varying in macronutrient intake. Association analysis was performed in pooled participants and different diet groups. Changes in blood levels of TMAO, choline, and l-carnitine from baseline to 6 months after the dietary intervention were calculated. RESULTS We found that a greater reduction in plasma levels of TMAO from baseline to 6 months was associated with a greater loss in whole-body BMD at 6 months and 2 years (P = 0.03 and P = 0.02). The greater reduction in TMAO was also associated with a greater loss in spine BMD (P = 0.005) at 2 years, independent of body weight changes. The associations were not modified by baseline diabetes status and glycemic levels. Changes in l-carnitine, a precursor of TMAO, showed interactions with dietary fat intake in regard to changes of spine BMD and hip BMD at 6 months (all P &amp;lt; 0.05). Participants with the smallest decrease in l-carnitine showed less bone loss in the low-fat diet group than the high-fat diet group (Pspine = 0.03 and Phip = 0.02). CONCLUSIONS TMAO might protect against BMD reduction during weight loss, independent of diet interventions varying in macronutrient content and baseline diabetes risk factors. Dietary fat may modify the relation between change in plasma l-carnitine level and changes in BMD. Our findings highlight the importance of investigating the relation between TMAO and bone health in patients with diabetes.