tbuckley/cabot-search huggingface dataset:
Prevalence of COVID-19 diagnosis in Dutch CML patients during the 2020 SARS-CoV2 pandemic. A prospective cohort study
Authors: Geneviève I. C. G. Ector, Elisabeth G. W. Huijskens, Nicole M. A. Blijlevens, Peter E. Westerweel
Journal: Leukemia (2020)

We read with interest the article by Li et al. first to report on COVID-19 in patients with chronic myeloid leukaemia (CML) [1].They found an increased COVID-19 prevalence in CML patients of the Hubei region in China when compared to the prevalence of the general population of that region.Unfortunately, in this retrospective study, follow-up data were not provided and a direct control group was not included.We report preliminary results of a prospective Dutch observational cohort study that assessed differences in susceptibility for COVID-19 and severity of the disease course in adult CML patients and their adult housemates during the SARS-CoV2 pandemic (the first COVID-19 case was identified on February 27th in the Netherlands).Patients were invited to participate via CMyLife [2], a nationwide web-based portal focused on Dutch CML patients, from April 6th 2020 onwards.If available, their adult housemates (e.g., spouses) were included as control group, providing a better representation of the general population.Surveys were performed at baseline and at a 2-weekly follow-up period.CML patients receiving TKI treatment or having a discontinuation of their TKI treatment were invited to participate.The study was approved by the Radboudumc institutional ethics committee and digital informed consent was obtained from both patients and partners.
Learning curve of kidney transplantation in a high-volume center: A Cohort study of 1466 consecutive recipients
Authors: Kosei Takagi, Loubna Outmani, Hendrikus J.A.N. Kimenai, Turkan Terkivatan, Khe T.C. Tran, Jan N.M. Ijzermans, Robert C. Minnee
Journal: International Journal of Surgery (2020)

The purpose of this study was to evaluate surgical outcomes of kidney transplantation (KTX) based on surgeon volume and surgeon experience, and to develop the learning curve model for KTX using the cumulative sum (CUSUM) analysis.A retrospective review of 1466 consecutive recipients who underwent KTX between 2010 and 2017 was conducted. In total, 51 surgeons, including certified transplant surgeons, transplant fellows and surgical residents were involved in these procedures using a standardized protocol. Outcomes were compared based on surgeon volume (low [1-30] versus high [31≥] volume) and surgeon's type (consultant surgeons, fellows or residents).Operative time (129 versus 135 min, P < 0.001) and warm ischemia time (20.9 versus 24.2 min, P < 0.001) were significantly shorter in the high-volume group, however postoperative outcomes were equal in both groups. The CUSUM analysis revealed that approximately 30 procedures were necessary to improve surgical skills. In addition, no effect of surgeon's type including consultant surgeons, fellows and residents on postoperative outcomes was found.Surgical training in KTX using a standardize protocol can be accomplished with a steep learning curve without compromising perioperative outcomes under the careful selection of surgeons and procedures.
Abstract 12629: Impact of Cardiologist Consultation on the Likelihood of Receiving Guideline Directed Medical Therapy for General Medicine Admissions With Heart Failure
Authors: Tatvam T Choksi, Matthew Cerasale, Rhys Chua, Corey E Tabit
Journal: Circulation (2018)

Introduction: Prior studies suggest that involvement of a cardiologist in the care of hospitalized patients with a primary diagnosis of heart failure (HF) improves outcomes. However, less is known ...
Prevalence and pathogenicity of autoantibodies in patients with idiopathic CD4 lymphopenia
Authors: Ainhoa Perez-Diez, Chun-Shu Wong, Xiangdong Liu, Harry Mystakelis, Jian Song, Yong Lu, Virginia Sheikh, Jeffrey S. Bourgeois, Andrea Lisco, Elizabeth Laidlaw, Cornelia Cudrici, Chengsong Zhu, Quan-Zhen Li, Alexandra F. Freeman, Peter R. Williamson, Megan Anderson, Gregg Roby, John S. Tsang, Richard Siegel, Irini Sereti
Journal: Journal of Clinical Investigation (2020)

BACKGROUND. Idiopathic CD4 lymphopenia (ICL) is defined by persistently low CD4+ cell counts (<300 cells/μL) in the absence of a causal infection or immune deficiency and can manifest with opportunistic infections. Approximately 30% of ICL patients develop autoimmune disease. The prevalence and breadth of their autoantibodies, however, and their potential contribution to pathogenesis of ICL remain unclear.
The DNA methylation landscape of advanced prostate cancer
Authors: Shuang G. Zhao, William S. Chen, Haolong Li, Adam Foye, Meng Zhang, Martin Sjöström, Rahul Aggarwal, Denise Playdle, Arnold Liao, Joshi J. Alumkal, Rajdeep Das, Jonathan Chou, Junjie T. Hua, Travis J. Barnard, Adina M. Bailey, Eric D. Chow, Marc D. Perry, Ha X. Dang, Rendong Yang, Ruhollah Moussavi-Baygi, Li Zhang, Mohammed Alshalalfa, S. Laura Chang, Kathleen E. Houlahan, Yu-Jia Shiah, Tomasz M. Beer, George Thomas, Kim N. Chi, Martin Gleave, Amina Zoubeidi, Robert E. Reiter, Matthew B. Rettig, Owen Witte, M. Yvonne Kim, Lawrence Fong, Daniel E. Spratt, Todd M. Morgan, Rohit Bose, Franklin W. Huang, Hui Li, Lisa Chesner, Tanushree Shenoy, Hani Goodarzi, Irfan A. Asangani, Shahneen Sandhu, Joshua M. Lang, Nupam P. Mahajan, Primo N. Lara, Christopher P. Evans, Phillip Febbo, Serafim Batzoglou, Karen E. Knudsen, Housheng H. He, Jiaoti Huang, Wilbert Zwart, Joseph F. Costello, Jianhua Luo, Scott A. Tomlins, Alexander W. Wyatt, Scott M. Dehm, Alan Ashworth, Luke A. Gilbert, Paul C. Boutros, Kyle Farh, Arul M. Chinnaiyan, Christopher A. Maher, Eric J. Small, David A. Quigley, Felix Y. Feng
Journal: Nature Genetics (2020)
Natural rubber latex allergy
Authors: K. Turjanmaa, H. Alenius, S. Mäkinen-Kiljunen, T. Reunala, T. Palosuo
Journal: Allergy (1996)

The history of natural rubber latex (NRL) allergy is relatively short; the first case reports appeared in 1979-80 in the European (1, 2) and in 1989 in the North American literature (3-5).During the last 10 years, NRL allergy has been acknowledged as a major occupational problem among glovewearing health-care workers.In addition, several authors have noted that NRL allergy also occurs frequently outside the health-care environment.Populations at increased risk include not only glove-wearing kitchen workers and housekeeping personnel (6-8) but also children who may exhibit allergic reactions when blowing up balloons (9, 10).Even patients allergic to various fruits, such as banana and avocado, may experience allergic reactions from NRL and vice versa (11-14).The wide spectrum of symptoms of NRL allergy range from mild contact urticaria to asthma and anaphylactic reactions (3,(15)(16)(17).Severe allergic reactions are frequently reported to occur intraoperatively in children with spina bifida (18, 19).It has recently been emphasized that NRL allergens become easily airborne with glove powder and that persons sensitized to NRL may also suffer from occupational asthma (20)(21)(22)(23).The presence of specific IgE in NRL-allergic patients may be verified by skin prick tests (SPT) or by serologic methods such as .The limited knowledge of the relevant NRL aller-
SAT0559 INCREASED FREQUENCY OF INTER- AND SUBMETATARSAL BURSITIS AND MORTON’S NEUROMA IN RHEUMATOID ARTHRITIS: RESULTS OF A LARGE CASE-CONTROLLED MRI STUDY OF FOREFEET IN PATIENTS WITH EARLY ARTHRITIS AND HEALTHY CONTROLS
Authors: Y. Dakkak, E. Niemantsverdriet, A. Van der Helm - van Mil, M. Reijnierse
Journal: Annals of the Rheumatic Diseases (2020)

Background: The forefoot is a preferential location for tendon and joint inflammation in rheumatoid arthritis (RA). Some imaging studies suggested that intermetatarsal and submetatarsal pathology (such as bursitis and Morton’s neuroma) are also involved in RA, but these studies were small and its association was not thoroughly explored. Objectives: To determine whether intermetatarsal bursitis (IMB), Morton’s neuroma (MN) and submetatarsal bursitis (SMB) occur more often in early RA, compared to patients with other early arthritides and healthy controls. Contrast-enhancement in the subcutis that has been described as diffuse submetatarsal alterations (DSMA) were also included. Methods: In this cross-sectional cohort-study, consecutive patients with RA, other arthritides and healthy controls underwent MRI of unilateral forefoot. Two readers, a trained PhD-student an experienced MSK-radiologist, scored IMB, MN, SMB and DSMA in consensus, and measured transverse and dorsoplantar diameters of IMB, MN and SMB. Logistic regression models determined their association with RA, and test characteristics for RA were calculated. Lesion-sizes were plotted. Results: 634 participants underwent MRI: 157 consecutive patients with RA (109 women; age 59±11SD), 284 with other early arthritides (158 women; age 56±17SD), and 193 healthy controls (136 women; age 50±16SD). Univariably, IMB, MN and SMB were more prevalent in RA (all P&lt;0.001), DSMA was not (P=0.16). Multivariably, MB, SMB and MN were all associated with RA independent of each other (P&lt;0.016). IMB was most frequent (sensitivity 69%), followed by SBM and MN (25% and 19%), specificity was high (70%, 96%, 94% respectively compared to other arthritides and 84%, 99% and 97% compared to healthy controls). Although IMB, MN and SNB were more frequent in RA, the lesion-size was mainly similar in all groups. For MN a dorsoplantar diameter &gt;6mm or transverse diameter &gt;5mm was highly specific (specificity 100% compared to healthy controls), however it was infrequent (sensitivity 12% and 13%, respectively). For IMB and SMB no cut-off size could be distinguished with high specificity. Conclusion: Intermetatarsal bursitis, Morton’s neuroma and submetatarsal bursitis are increased prevalent in early RA and could be considered as disease features. Disclosure of Interests: None declared
Cell proliferation arrest and tumor cell destruction by low intensity, frequency tuned electric fields
Authors: Yoram Palti, Rosa Schneiderman, Zoya Gurvich, Erez Dekel, Aviran Itzhaki, Yoram Wasserman, Rachel Schatzberger, Eilon D. Kirson
Journal: Cancer Research (2004)

4331  We have shown for the first time that low intensity, intermediate frequency, alternating electric fields, delivered by means of insulated electrodes, have a profound effect on all living cells and tissues tested. The fields had a strong inhibitory effect on the growth rate and viability of a variety of human and rodent tumor cell lines (Patricia C, U-118, U-87, H-1299, MDA231, PC3, B16F1, F-98, C-6, RG2, and CT-26). These potentially tumor treating fields (TTFields) were applied to cells in culture via electrically insulated wires placed within the culture dishes. The effect of TTFields on cultures was assessed periodically during treatment using direct cell count, colorimetric cell number assessment or time-lapse microphotography. The same fields also had a profound effect on malignant tumors in animals. TTFields were applied to tumor bearing rodents either through intradermally implanted insulated electrodes, or through surface electrodes insulated with a specialized, high dielectric constant, insulation. The inhibitory effect of the TTFields on cancerous cell replication was found to be non-thermal and to selectively affect cell division in two modes: destruction of cells while undergoing division, and arrest of cell proliferation. The first mode of action is manifested by rapid disintegration of the dividing cells, while the second is associated with interference with the proper formation of the mitotic spindle. The last effect was demonstrated by post treatment staining of cultures with fluorescent antibodies against various intracellular constituents. Both effects, which are frequency dependent, are consistent with the computed directional forces exerted, by these specific fields, on charges and dipoles within the dividing cells. In view of the fact that in-vivo treatment of tumors in mice and rats, resulted in significant slowing of tumor growth and extensive destruction of tumor cells within 3 to 6 days, the described technology can potentially serve as a novel therapeutic modality for malignant tumors.
<i>SOD1</i>Suppression with Adeno-Associated Virus and MicroRNA in Familial ALS
Authors: Christian Mueller, James D. Berry, Diane M. McKenna-Yasek, Gwladys Gernoux, Margaret A. Owegi, Lindsay M. Pothier, Catherine L. Douthwright, Dario Gelevski, Sarah D. Luppino, Meghan Blackwood, Nicholas S. Wightman, Derek H. Oakley, Matthew P. Frosch, Terrence R. Flotte, Merit E. Cudkowicz, Robert H. Brown
Journal: New England Journal of Medicine (2020)

Summ a
P-370 Comprehensive targeted genomic profiling and comparative genomic analysis to identify molecular mechanisms driving cancer progression in young-onset sporadic colorectal cancer
Authors: G. Atikukke, A. Alkhateeb, L. Porter, B. Fifield, D. Cavallo-Medved, J. Facca, T. Elfiki, A. Elkeilani, L. Rueda, S. Misra
Journal: Annals of Oncology (2020)
Evaluation of an Unsanctioned Safe Consumption Site in the United States
Authors: Alex H Kral, Barrot H Lambdin, Lynn D Wenger, Pete J Davidson
Journal: New England Journal of Medicine (2020)

Data on nonfatal overdose hospitalizations and emergency department (ED) visits were obtained from the Healthcare Cost and Utilization Project's (HCUP) National Inpatient Sample (NIS) and Nationwide Emergency Department Sample (NEDS) 2016 surveys, which are sponsored by the Agency for Healthcare Research and Quality.Data on mortality were obtained from the National Vital Statistics System's (NVSS) 2017 mortality files through CDC WONDER (Wide-ranging Online Data for Epidemiology Research).
日本人の関節リウマチにおけるACPA値に対するHLA-DRB1対立遺伝子の定量的効果: HLA-DRB1 * 09:01成層後のACPA値への共有エピトープの強くはない遺伝学的影響 | 文献情報 | J-GLOBAL 科学技術総合リンクセンター
Authors: Terao Chikashi, Ikari Katsunori, Ohmura Koichiro, Suzuki Taku, Iwamoto Takuji, Takasugi Kiyoshi, Saji Hiroo, Taniguchi Atsuo, Momohara Shigeki, Yamanaka Hisashi, Matsuda Fumihiko, Mimori Tsuneyo
Journal: Annals of the Rheumatic Diseases (2012)
Efficacy and Safety of Glimepiride With or Without Linagliptin Treatment in Patients With HNF1A Diabetes (Maturity-Onset Diabetes of the Young Type 3): A Randomized, Double-Blinded, Placebo-Controlled, Crossover Trial (GLIMLINA)
Authors: Alexander S. Christensen, Sofie Hædersdal, Julie Støy, Heidi Storgaard, Ulla Kampmann, Julie L. Forman, Marta Seghieri, Jens J. Holst, Torben Hansen, Filip K. Knop, Tina Vilsbøll
Journal: Diabetes Care (2020)

OBJECTIVE Sulfonylureas are first-line treatment of hepatocyte nuclear factor 1-α (HNF1A) diabetes (maturity-onset diabetes of the young type 3), but many patients do not achieve optimal glycemic control without episodes of hypoglycemia. We investigated the combination of the sulfonylurea glimepiride and the dipeptidyl peptidase 4 inhibitor linagliptin versus glimepiride monotherapy with respect to glycemic variability, glycemic control, and risk of hypoglycemia. RESEARCH DESIGN AND METHODS In a randomized, double-blinded, crossover trial, patients with HNF1A diabetes (n = 19; mean ± SD age 43 ± 14 years, BMI 24.8 ± 2.8 kg/m2, and glycated hemoglobin [HbA1c] 7.4 ± 0.2% [57.1 ± 7.3 mmol/mol]) were randomly assigned to treatment with glimepiride + linagliptin 5 mg (16 weeks), washout (4 weeks), and glimepiride + placebo (16 weeks) (or vice versa). Glimepiride was titrated targeting a fasting plasma glucose of 4.5–6.0 mmol/L without hypoglycemia. Treatments were evaluated by continuous glucose monitoring (CGM), HbA1c, and meal test. RESULTS Compared with glimepiride + placebo, glimepiride + linagliptin did not significantly improve the primary end point, mean amplitude of glycemic excursions (MAGE) (mean difference −0.7 mmol/L, P = 0.1540), but displayed significant reductions in coefficient of variation on CGM (−3.6%, P = 0.0401), HbA1c (−0.5%, P = 0.0048), and glimepiride dose (−0.7 mg/day, P = 0.0099). β-cell glucose sensitivity (assessed as C-peptide–to–glucose ratio) during meal test improved with glimepiride + linagliptin. Incidences of hypoglycemia were similar with both treatments. CONCLUSIONS Linagliptin as add-on treatment to glimepiride improved glycemic variability and control without increasing risk of hypoglycemia in patients with HNF1A diabetes.
Vascular contributions to 16p11.2 deletion autism syndrome modeled in mice
Authors: Julie Ouellette, Xavier Toussay, Cesar H. Comin, Luciano da F. Costa, Mirabelle Ho, María Lacalle-Aurioles, Moises Freitas-Andrade, Qing Yan Liu, Sonia Leclerc, Youlian Pan, Ziying Liu, Jean-François Thibodeau, Melissa Yin, Micael Carrier, Cameron J. Morse, Peter Van Dyken, Christopher J. Bergin, Sylvain Baillet, Christopher R. Kennedy, Marie-Ève Tremblay, Yannick D. Benoit, William L. Stanford, Dylan Burger, Duncan J. Stewart, Baptiste Lacoste
Journal: Nature Neuroscience (2020)
P-207 Impact of renal function on CAPOX / FOLFOX adjuvant chemotherapy in colon cancer
Authors: Y. Nagata, R. Sawada, S. Sasaki, H. Sugano, T. Nishimura, M. Noguchi, S. Yatabe, Y. Takeda, D. Ito, M. Ohkuma, E. Nagasaki, M. Kosuge, K. Amano, K. Eto, M. Saruta
Journal: Annals of Oncology (2020)
Abstract 15958: Burden and Consequences of Financial Hardship From Medical Bills Among Non-Elderly Adults With Diabetes Mellitus in The United States
Authors: Cesar Caraballo, Javier Valero-Elizondo, Rohan Khera, Shiwani Mahajan, Gowtham Grandhi, Salim S Virani, Harlan M Krumholz, Khurram Nasir
Journal: Circulation (2019)

Background: The growing out-of-pocket costs among patients with diabetes mellitus (DM) represents a serious risk of financial hardship for Americans. In this study, we describe the national burden ...
Abstract 15192: Comparative Safety and Efficacy of Rivaroxaban, Dabigatran and Apixaban in Obese and Morbidly Obese Patients With Heart Failure and Non-Valvular Atrial Fibrillation: A Real World Analysis
Authors: Yashasvi Chugh, Hanumanthu B Krishna, Renato Q Ayala, Ignacio Zepeda, Dan Li, Carola A Gonzalez, Kavisha Patel, Carlos Gongora, Ramya Kallur, Ujjwal Rastogi, Shobhit Piplani, Sanjay K Chugh, Michael Grushko, Robert T Faillace
Journal: Circulation (2018)

Introduction: Obese and morbidly obese patients are under-represented in clinical trials of non-vitamin K oral anticoagulants (NOAC). Patients with atrial fibrillation (AF) and congestive heart fai...
Regular review: Treatment of Helicobacter pylori infection
Authors: W. A de Boer
Journal: BMJ (2000)

The bacterium Helicobacter pylori can infect the stomach during childhood and cause lifelong chronic gastritis, which can lead to peptic ulcer disease. Curing H pylori infection cures ulcer disease.1–5 And since reinfection in adults is extremely rare,6 adequate treatment permanently cures this former chronic recurrent, serious disease. If ulcers do not recur neither do ulcer perforation or bleeding; quality of life increases,7 sick leave decreases, and less money is spent on visiting the doctor and drugs.

Antibiotic resistance needs to be taken into account when designing treatment for H pylori infection.8 Over the past decade many different therapies were promoted and recommendations changed rapidly. Most doctors lost track, and a great variety of treatments is being used.9 In this article we will try to provide a basic framework on which treatment can be based.

#### Summary points

The therapeutic goal is to cure H pylori infection in all ulcer patients

Several equally effective regimens are available, but even the best fail in 5-20% of patients

Antibiotic resistance is usually induced after failure, and initial regimens should not compromise future therapeutic possibilities

Doctors should choose two complementary regimens, which if used consecutively come close to 100% cure

Treatment should start with a regimen based on clarithromycin with a back up regimen based on metronidazole unless resistance is above 15%, in which case the order should be reversed

Triple regimens which combine clarithromycin and metronidazole should not be used as there is no valid empirical back up regimen after failure

This article is based largely on our experience in treating H pylori infection. We base our recommendations on basic bacteriological principles and on a regularly updated in-house computer database that contains the results of all published therapeutic studies.

Treatment to eradicate H pylori in patients with a proved …
Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice
Authors: Fangping Jia, Pan Diao, Xiaojing Wang, Xiao Hu, Takefumi Kimura, Makoto Nakamuta, Ibuki Nakamura, Saki Shirotori, Yoshiko Sato, Kyoji Moriya, Kazuhiko Koike, Frank J. Gonzalez, Jun Nakayama, Toshifumi Aoyama, Naoki Tanaka
Journal: Liver Cancer (2020)

Dietary restriction (DR) is a preventive strategy for obesity, metabolic syndrome, cardiovascular disease, and diabetes. Although an interconnection between obesity, metabolic syndrome, fatty liver, and hepatocellular carcinoma has been documented, the mechanism and impact of DR on steatosis-derived hepatocarcinogenesis are not fully understood. This study aimed to evaluate whether DR can prevent hepatic tumorigenesis.Male hepatitis C virus core gene transgenic (HCVcpTg) mice that develop spontaneous age-dependent insulin resistance, hepatic steatosis, and ensuing liver tumor development without apparent hepatic fibrosis, were fed with either a control diet ad libitum (control group) or 70% of the same control diet (DR group) for 15 months, and liver phenotypes were investigated.DR significantly reduced the number and volume of liver tumors. DR attenuated hepatic oxidative and endoplasmic reticulum stress and markedly suppressed nuclear factor-κB, signal transducer and activator of transcription 3 (STAT3) and STAT5, and phosphorylation of extracellular signal-regulated kinase, leading to downregulation of several pro-oncogenic mediators, such as cyclin D1. Serum insulin and insulin-like growth factor 1 levels, as well as hepatic expression of insulin receptor substrate 1/2, phosphatidylinositol-3 kinase, and serine/threonine-protein kinase AKT, were downregulated by DR. A transcriptome analysis revealed that STAT3 signaling and lipogenesis were the most suppressed hepatocarcinogenic pathways affected by DR. Additionally, DR stimulated autophagy and p62/sequestosome 1 degradation, enhanced phosphorylation of AMP-activated protein kinase α, increased fibroblast growth factor 21 expression, and attenuated expression of senescence-associated secretory phenotypes.DR suppressed steatosis-associated hepatic tumorigenesis in HCVcpTg mice, mainly due to attenuation of pathways involved in inflammation, cellular stress, cell proliferation, insulin signaling, and senescence. These findings support the notion that persistent 30% reduction of daily food intake is beneficial for preventing steatosis-associated hepatocarcinogenesis caused by HCV core protein.