tbuckley/cabot-search huggingface dataset:
Abstract P202: Violence and Midlife Carotid Artery Intima-media Thickness in Mexican Women
Authors: Mario Flores, Unnur Valdimarsdóttir, Ruy Lopez-Ridaura, Adriana Monge, Carlos Cantú-Brito, Rebekka Lynch, Martín Lajous
Journal: Circulation (2016)

Introduction: Violence against women remains globally one of the most important human rights violations and public health threats. Yet, data on the potential impact of lifetime exposure to violence, an important stressor, on cardiovascular disease (CVD) are scarce. Hypothesis: Adult women with a history of childhood and/or adult exposure to violence are at increased risk of subclinical CVD compared to women without this history. Methods: We evaluated the association of childhood and adult exposure to violence and carotid artery intima-media thickness (IMT) in 634 disease-free women from the Mexican Teachers’ Cohort. In 2012-13, study participants retrospectively responded to 12 violence-related items from the Life Stressor Checklist questionnaire. We categorized violence as neglect, and observed, physical and sexual violence, in childhood and adulthood. IMT was measured by standardized neurologists through ultrasound and log-transformed. We defined carotid atherosclerosis as IMT ≥0.8mm or plaque. We used multivariable linear and logistic regression models to assess the association between violence, IMT and carotid atherosclerosis. Results: In childhood, the prevalence of neglect was 8.2%, observed violence 22.2%, sexual violence 6.9% and physical violence 8.2%. In adulthood, neglect was present in 17.4% participants, observed violence in 21.6%, sexual violence in 10.4% and physical violence in 27.4%. Childhood exposure to sexual violence appeared to be associated to IMT in midlife but remained non-significant. In adulthood, we observed an association between exposure to physical violence and IMT when comparing exposed to unexposed women (multivariable-adjusted mean % difference=2.3%; 95%CI 0.1, 4.6). The multivariable-adjusted odds ratio for carotid atherosclerosis was 1.69 (95%CI 1.07, 2.69) comparing women who reported physical violence relative to those who did not. Conclusions: Exposure to certain types of violence may be associated with increased subclinical CVD in middle-aged women.
Prevalence and determinants for xerosis cutis in the middle-aged and elderly population: A cross-sectional study
Authors: Selma Mekić, Leonie C. Jacobs, David A. Gunn, Andrew E. Mayes, M. Arfan Ikram, Luba M. Pardo, Tamar Nijsten
Journal: Journal of the American Academy of Dermatology (2018)
Abstract 19189: Hindlimb Ischemia Impairs Endothelial Recovery and Increase Arterial Neointimal Proliferation in Response to Injury of a Remote District: The Role of Micrornas
Authors: Sabato Sorrentino, Claudio Iaconetti, Salvatore De Rosa, Alberto Polimeni, Jolanda Sabatino, Francesco Passafaro, Laura Tamme, Antonio Curcio, Daniele Torella, Ciro Indolfi
Journal: Circulation (2017)

Introduction: Peripheral ischemia is associated with higher degree of endothelial dysfunction in coronary district, as well as to worse prognosis after percutaneous coronary interventions. Hypothesis: to evaluate the effect of peripheral ischemia on arterial remodeling of remote district. Methods: Male Wistar Rats were randomly divided a group underwent hindlimb ischemia through ligation of the femoral artery (FL), and the other group received no ligation (sham operated). Seven days later, both groups underwent balloon injury (BI) of the carotid artery Results: Ongoing hindlimb Ischemia significantly enhances neointima formation (neointima/media ratio = 1,58±0,192 versus 1,18±0,138 of control group, n=10), impairs endothelial recovery and increase in infiltration of macrophage cells at 14 days after BI compared to control group. In addition, the expression level of myocardin was markedly decreased, with an up-regulation of inflammatory markers (I-CAM and V-CAM) in the endothelial cells extract. Using real...
Diagnostic performance and impact of routinely implemented Xpert® MTB/RIF assay in a setting of high incidence of drug-resistant TB in Odessa Oblast, Ukraine
Authors: V. Nikolayevskyy, I. Kontsevaya, E. Nikolaevskaya, E. Surkova, S. Samchenko, S. Esipenko
Journal: Clinical Microbiology and Infection (2018)
Genetic susceptibility to radiation-induced breast cancer after Hodgkin lymphoma
Authors: Annemieke W. J. Opstal-van Winden, Hugoline G. de Haan, Michael Hauptmann, Marjanka K. Schmidt, Annegien Broeks, Nicola S. Russell, Cécile P. M. Janus, Augustinus D. G. Krol, Frederieke H. van der Baan, Marie L. De Bruin, Anna M. van Eggermond, Joe Dennis, Hoda Anton-Culver, Christopher A. Haiman, Elinor J. Sawyer, Angela Cox, Peter Devilee, Maartje J. Hooning, Julian Peto, Fergus J. Couch, Paul Pharoah, Nick Orr, Douglas F. Easton, Berthe M. P. Aleman, Louise C. Strong, Smita Bhatia, Rosie Cooke, Leslie L. Robison, Anthony J. Swerdlow, Flora E. van Leeuwen
Journal: Blood (2018)
Abstract 15100: Reduction in Total Cardiovascular Events With the PCSK9 Inhibitor Evolocumab in Patients With Cardiovascular Disease in the FOURIER Trial
Authors: Sabina A Murphy, Terje R Pedersen, Zbigniew A Gaciong, Richard Ceska, Marat V Ezhov, Derek Connolly, Oleg Kraydashenko, J. Wouter Jukema, Kalman Toth, Matti J Tikkanen, Kyungah Im, Stephen D Wiviott, Christopher Kurtz, Narimon Honarpour, Robert P Giugliano, Anthony C Keech, Peter S Sever, Marc S Sabatine
Journal: Circulation (2017)

Introduction: Intensive LDL-C lowering with the PCSK9i evolocumab (EvoMab) significantly reduced the risk of major vascular events in pts with stable atherosclerotic disease treated on background s...
Radiation Therapy As a Bridging Strategy for Refractory Diffuse Large B Cell Lymphoma Patients Awaiting CAR T Manufacturing of Axicabtagene Ciloleucel
Authors: Michael D. Jain, Julio C. Chavez, Bijal D. Shah, Farhad Khimani, Aleksandr Lazaryan, Marco L. Davila, Hien D. Liu, Aaron D Falchook, Timothy Robinson, Sungjune Kim, Frederick L. Locke
Journal: Blood (2018)
SP0053 European diagnostic criteria for polymyalgia rheumatica
Authors: H Bird
Journal: Annals of the Rheumatic Diseases (2001)

<h3></h3> A variety of separate diagnostic criteria sets exist for polymyalgia rheumatica. These include those proposed in 1979,<sup>1</sup> 1981<sup>2</sup> and 1989.<sup>3</sup> All differ slightly, the optimum criteria still having to be determined. In 1997, the Polymyalgia Rheumatica Special Interest Group was established under the auspices of the EULAR Standing Committee for International Clinical Studies. Twenty participating centres throughout Europe between them promised to make available 200 new patients each year for the comparison of criteria sets. In parallel patients, where suitable, were recruited to a study to evaluate, for the first time, response criteria for this condition. It was hoped that both studies would lead to more accurate assessment of the several drugs then being claimed to be steroid sparing agents. Collection of data terminated at the end of the year 2000. Although, as this abstract is prepared, some data sets are still awaited, it is likely that analysis will be based on data from 312 patients judged to have polymyalgia rheumatica recruited from 13 centres. The vast majority of these patients, judged by a consensus of experts to have polymyalgia rheumatica, have provided a database for comparison of the various diagnostic criteria sets. On the basis of this, optimum European diagnostic criteria will be proposed. Investigators are encouraged to use this in their research on polymyalgia rheumatica to further substantiate their reliability. A handout listing the new criteria will be available at the time of the presentation. <h3>References</h3> Bird HA, <i>et al</i>. Ann Rheum Dis. 1979;38:434–9 Jones JG, Hazleman BL. Ann Rheum Dis. 1981;<b>40</b>:1–5 Nobunaga M, <i>et al</i>. Jpn J Med. 1989;28:452–6
Abstract 18455: High Burden of Prehypertension in Northand South India: Findings From a Large Community Based Study
Authors: Sailesh Mohan, Shreeparna Ghosh, Nikhil Srinivasapura Venkateshmurthy, Prashant Jarhyan, Rajesh Khatkar, Balaji Gummudi, Bhaskara Rao Malipeddi, Nikhil Tandon, K.Srinath Reddy, Dorairaj Prabhakaran
Journal: Circulation (2017)

Introduction: India faces a high burden of uncontrolled hypertension, which is driving the escalating cardiovascular disease (CVD) epidemic. However, limited information is available on the burden ...
Efficacy of Chemotherapy or Chemo-Anti-PD-1 Combination after Unsatisfactory Response of Anti-PD-1 Therapy for Relapsed and Refractory Hodgkin Lymphoma: A Retrospective Series from Lysa Centers
Authors: Cédric Rossi, Julia Gilhodes, Marie Maerevoet, Charles Herbaux, Pauline Brice, Sylvain Garciaz, Cecile Borel, Loic Ysebaert, Lucie Oberic, Julien Lazarovici, Bénédicte Deau-Fisher, Jehan Dupuis, Adrien Chauchet, Julie Abraham, Fontanet Bijou, Aspasia Stamatoullas-Bastard, Jean Valère Malfuson, Camille Golfier, Camille Laurent, Salim Kanoun, Thomas Filleron, Rene-Olivier Casasnovas, Hervé Ghesquières
Journal: Blood (2017)
Tumour Seeding in the Tract of Percutaneous Renal Tumour Biopsy: A Report on Seven Cases from a UK Tertiary Referral Centre
Authors: Philip S. Macklin, Mark E. Sullivan, Charles R. Tapping, David W. Cranston, Guy M. Webster, Ian S.D. Roberts, Clare L. Verrill, Lisa Browning
Journal: European Urology (2018)
CD79a Is Associated with Central Nervous System Infiltration of Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia
Authors: Lennart Lenk, Fotini Vogiatzi, Michela Carlet, Christian Vokuhl, Gunnar Cario, Martin Schrappe, Irmela Jeremias, Stephan Fuhrmann, Elias Hobeika, Hassan Jumaa, Ameera Alsadeq, Denis Martin Schewe
Journal: Blood (2018)
Abstract 16399: Use and Customization of Risk Scores for Predicting Cardiovascular Events Using Electronic Health Record Data
Authors: Julian Wolfson, David M Vock, Sunayan Bandyopadhyay, Gediminas Adomavicius, Patrick J O'Connor, Gabriela X Vazquez-Benitez
Journal: Circulation (2015)

Background: The Framingham Risk Score (FRS) and the ACC/AHA Pooled Cohort Score (PCS) are widely used in clinical practice to guide individual patient care decisions. However, these risk scores have been estimated and validated mostly using data from longitudinal cohort studies and their performance when applied to patient data extracted from electronic health records is less well-established. Methods: Risk factor and outcomes data were obtained from the electronic medical records and insurance claims of 84,130 adults aged 40-79 receiving care at a large health care delivery and insurance organization from 2001-2011. We assessed calibration and discrimination for four risk scores: the published versions FRS and PCS, and versions obtained by re-fitting the FRS and PCS Cox regression models using a subset of the available data. Population subgroups where the various models gave highly divergent risk predictions were identified using recursive partitioning techniques. Results: The original FRS was well-calibrated (Calibration statistic K &lt; 5.7, p = 0.13), but the original PCS was not ( K = 30, p &lt; 0.001). The original PCS yielded somewhat better discrimination than the original FRS (C-statistic C = 0.757 vs. 0.738). The refitted FRS ( K = 1.4, p = 0.71 and C = 0.754) and refitted PCS ( K = 8, p = 0.046 and C = 0.756) were both well-calibrated and showed good discrimination. The original and refitted FRS disagreed substantially on the risks of individuals within a number of population subgroups, most of which encompassed individuals under the age of 60; the original and refitted PCS differed substantially in their risk predictions for African-American males; and the refitted FRS and PCS produced similar risk predictions across subgroups. Conclusions: Both the FRS and PCS are appropriate for use in clinical decision support systems which rely on electronic health data, though it may be advisable to refit the statistical models they are based on using available data from the target population to ensure acceptable calibration and discrimination performance.
Machine Learning Models for Genetic Risk Assessment of Infants with Non-Syndromic Orofacial Cleft
Authors: Shi-Jian Zhang, Peiqi Meng, Jieni Zhang, Peizeng Jia, Jiuxiang Lin, Xiangfeng Wang, Feng Chen, Xiaoxing Wei
Journal: Genomics Proteomics & Bioinformatics (2018)

Abstract The isolated type of orofacial cleft, termed non-syndromic cleft lip with or without cleft palate (NSCL/P), is the second most common birth defect in China, with Asians having the highest incidence in the world. NSCL/P involves multiple genes and complex interactions between genetic and environmental factors, imposing difficulty for the genetic assessment of the unborn fetus carrying multiple NSCL/P-susceptible variants. Although genome-wide association studies (GWAS) have uncovered dozens of single nucleotide polymorphism (SNP) loci in different ethnic populations, the genetic diagnostic effectiveness of these SNPs requires further experimental validation in Chinese populations before a diagnostic panel or a predictive model covering multiple SNPs can be built. In this study, we collected blood samples from control and NSCL/P infants in Han and Uyghur Chinese populations to validate the diagnostic effectiveness of 43 candidate SNPs previously detected using GWAS. We then built predictive models with the validated SNPs using different machine learning algorithms and evaluated their prediction performance. Our results showed that logistic regression had the best performance for risk assessment according to the area under curve. Notably, defective variants in MTHFR and RBP4, two genes involved in folic acid and vitamin A biosynthesis, were found to have high contributions to NSCL/P incidence based on feature importance evaluation with logistic regression. This is consistent with the notion that folic acid and vitamin A are both essential nutritional supplements for pregnant women to reduce the risk of conceiving an NSCL/P baby. Moreover, we observed a lower predictive power in Uyghur than in Han cases, likely due to differences in genetic background between these two ethnic populations. Thus, our study highlights the urgency to generate the HapMap for Uyghur population and perform resequencing-based screening of Uyghur-specific NSCL/P markers.
Aurora Kinase a/MDM2-Mediated SETD2 Loss of Function in Chronic Myeloid Leukemia Patients in Blast Crisis Induces Genetic Instability and Can be Therapeutically Targeted
Authors: Manuela Mancini, Sara De Santis, Cecilia Monaldi, Luana Bavaro, Margherita Martelli, Fausto Castagnetti, Gabriele Gugliotta, Gianantonio Rosti, Maria Chiara Fontana, Elisa Dan, Barbara Sinigaglia, Alessandra Iurlo, Nicola Orofino, Elisabetta Abruzzese, Marzia Salvucci, Patrizia Pregno, Antonella Gozzini, Monica Crugnola, Francesco Albano, Massimiliano Bonifacio, Elisabetta Calistri, Mario Tiribelli, Gianni Binotto, Annalisa Imovilli, Elena Trabacchi, Sara Galimberti, Claudia Baratè, Elena Tenti, Michele Baccarani, Giovanni Martinelli, Michele Cavo, Simona Soverini
Journal: Blood (2018)
High Prevalence of Laryngeal Obstruction during Exercise in Severe Asthma
Authors: James H. Hull, Emil S. Walsted, Matt J. Pavitt, Andrew Menzies-Gow, Vibeke Backer, Guri Sandhu
Journal: American Journal of Respiratory and Critical Care Medicine (2018)

patients with severe asthma is associated with a decline in pulmonary function (7).Epithelial repair requires cell migration, proliferation, and differentiation to restore the structure after injury (8).As progenitor/stem cells, basal cells play a critical role in epithelial repair and undergo proliferation and differentiation in response to injury.Because they showed a persisting expansion after BT, we evaluated their proliferation.We observed that the number of proliferative (Ki-67 1 ) p63 1 cells decreased >12 months after BT, whereas the total number of p63 1 cells remained high.These data suggest that the local proliferation of basal cells participated in the observed p63 1 cell expansion shortly after BT, and that later other sources of progenitor cells likely sustained the observed higher number of p63 1 cells (9).This real-life study did not have a control group, and patients were asked to undergo bronchial biopsies at the time of the BT procedures.However, we believe that bronchial biopsies taken in the left lower lobe at the first bronchoscopy for right lower lobe BT treatment constitute an acceptable baseline.In conclusion, in severe asthma, the bronchial epithelium could be considered as an important target of BT treatment.BT causes epithelial injury, induces proliferation of basal progenitor cells, reduces mucin expression, and improves epithelial integrity.These results support BT as an effective treatment option for patients with severe uncontrolled asthma, and suggest that the observed clinical benefits could be related to BT-induced changes of the bronchial epithelium structure in addition to airway mucosa smooth muscle mass and nerve fiber changes.
DNA amplification is a common mechanism of oncogene activation in lung cancer
Authors: William Lockwood, Jennifer Kennett, Raj Chari, Bradley Coe, Luc Girard, Calum MacAulay, Stephen Lam, Adi Gazdar, John Minna, Wan Lam
Journal: Cancer Research (2008)

1719  Background: Genetic aberration and the corresponding activation of oncogenes is an important event in cancer development. This can occur through mechanisms such as mutation of DNA sequences, chromosomal translocations and segmental copy number changes, all which lead to deregulation of gene activity. The activation of oncogenes through gene amplification has been reported for many cancers. These mutations lead to an increase in gene dosage and in turn, can induce overexpression in cancer cells as a consequence. However, few genes have been shown to undergo this process as a mechanism of activation. The low incidence of oncogene amplification may be attributed to the failure of detection rather than governed by tumor biology. It is difficult to comprehensively identify genetic alterations using current molecular cytogenetic techniques due to their limited resolution, as small segmental amplifications may escape detection. Consequently their contribution to the oncogenic process may be grossly underestimated.  Objective: To determine the contribution of gene amplification to the activation of oncogenes in cancer genomes by high-resolution tiling array comparative genomic hybridization (CGH).  Methods: DNA was isolated from 104 cancer cell lines of multiple tissue origins. Cancer samples and normal reference DNA were differentially labeled for hybridization analysis using an array CGH platform that spans the human genome with a tiling set of BAC clones. Array data were assessed using SeeGH software and regions of genomic amplification were defined and compiled for each sample.  Results: Over 100 tumor genome profiles of diverse tissue origins were generated. In addition to identifying known oncogenes previously shown to be activated by other genetic mechanisms that are frequently amplified, the delineation of amplification “hotspots” in the genome showed differences between tumor types and allowed the discovery of novel genes potentially involved in tumorigenesis. These hotspots were enriched for genes related to cell proliferation, apoptosis and linage dependency, reflecting functions advantageous to tumor growth. Integration of parallel copy number and expression data highlighted the downstream impact of these amplifications on gene transcription levels in lung cancer cell lines and clinical tumors. For example, multiple downstream components of the EGFR family signaling pathway, including CDK5, AKT1, and SHC1, are overexpressed as a direct result of gene amplification in lung cancer. Conclusions: Our findings suggest that DNA amplification is far more common a mechanism of oncogene activation than previously believed and that specific regions of the cancer genome are hotspots of amplification.
Patients? reports or clinicians? assessments ? which are better for prognosticating? An observational study
Authors: Stone P, Gwilliam B, Keeley, Todd C, Gittens M, Kelly L, Barclay S, Roberts C
Journal: BMJ (2012)

Background The Prognosis in Palliative care Scale (PiPS) predicts survival in advanced cancer patients more accurately than a doctor's or a nurse's estimate. PiPS scores are derived using observer ratings of symptom severity and performance status. The purpose of this study was to determine whether patient-rated data would provide better prognostic estimates than clinician observer ratings. Patients and methods 1018 subjects with advanced cancer no longer undergoing tumour-directed therapy were recruited to a multi-centre study. Prognostic models were developed using observer ratings, patient ratings or a composite method that used patient ratings when available or else used observer ratings. The performance of the prognostic models was compared by determining the agreement between the models' predictions and the survival of study participants. Results All three approaches to model development resulted in prognostic scores that were able to differentiate between patients with a survival of ?days?, ?weeks? or ?months+?. However, the observer-rated models were significantly (p<0.05) more accurate than the patient-rated models. Conclusions A prognostic model derived using observer-rated data was more accurate at predicting survival than a similar model derived using patient self-report measures. This is clinically important because patient-rated data can be burdensome and difficult to obtain in patients with terminal illnesses.
Abstract 16938: Relationship of Healthy Diet with Components of Blood Pressure: a Study from the Hispanic Community Health Study/Study of Latinos
Authors: Natalie A Bello, Brian Claggett, Fatima Rodriguez, Jianwen Cai, Ashley Moncrieft, Karin Garcia, Marina Del Rios Rivera, Robert C Kaplan, Martha L Daviglus, Scott D Solomon, Susan Cheng
Journal: Circulation (2014)

Background: The Alternative Healthy Eating Index (AHEI-2010) is a measure of adherence to U.S. dietary guidelines and is inversely related to cardiovascular and diabetes risk. It is unknown if the ...
Pulmonary inflammatory myofibroblastic tumour and IgG<sub>4</sub>-related disease presenting with lower limb paralysis
Authors: Shuo Zhang, Shangzhu Zhang, Wen Zhang, Jia He, Juhong Shi, Xiaofeng Zeng
Journal: Thorax (2018)

A 40-year-old man presented with numbness of the lower limbs and pain in the lower back for 11 months. Abdominal CT revealed multiple retroperitoneal masses around the left renal hilus and abdominal aorta. Over the subsequent 4 months, the lesions progressed, resulting in hydronephrosis of the left kidney and bone destruction in the L2 vertebral body (figure 1). Three biopsies (two from the L2 vertebral body and one from the retroperitoneal mass) had been previously taken at another hospital. Pathological examination of all three biopsies had resulted in a diagnosis of IgG4-related disease (IgG4-RD) (figure 2). He had been taking a moderate dose of methylprednisolone (20 mg/day) for 4 months. Chest CT revealed a nodule in the apical segment of the right lung, 7 months after initial presentation. His symptoms did not improve on treatment with steroids. By 9 months after presentation, the patient had developed paralysis, hypoaesthesia, numbness and pain in both lower limbs. Intravenous methylprednisolone (250 mg/day) …