tbuckley/cabot-search huggingface dataset:
Why Are Mothers Still Passing Syphilis to Their Babies?
Authors: Rita Rubin
Journal: JAMA (2019)

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Clinical and Epidemiological Features Of Children With Egg Allergy (EA) Followed In A Brazilian Referral Center Of Allergy
Authors: Julio Cesar Gontijo, Luiza M. Marino, Barbara Luiza B Cancado, Marina Medeiros Caputo, Renan Augusto Pereira, Ana Carolina Rozalem, Carolina S. Aranda, Renata R. Cocco, Marcia C. Mallozi, Dirceu Sole
Journal: Journal of Allergy and Clinical Immunology (2019)
Interplay between TRAP1 and Sirtuin-3 Modulates Mitochondrial Respiration and Oxidative Stress to Maintain Stemness of Glioma Stem Cells
Authors: Hye-Kyung Park, Jun-Hee Hong, Young Taek Oh, Sung Soo Kim, Jinlong Yin, An-Jung Lee, Young Chan Chae, Jong Heon Kim, Sung-Hye Park, Chul-Kee Park, Myung-Jin Park, Jong Bae Park, Byoung Heon Kang
Journal: Cancer Research (2019)

Glioblastoma (GBM) cancer stem cells (CSC) are primarily responsible for metastatic dissemination, resistance to therapy, and relapse of GBM, the most common and aggressive brain tumor. Development and maintenance of CSCs require orchestrated metabolic rewiring and metabolic adaptation to a changing microenvironment. Here, we show that cooperative interplay between the mitochondrial chaperone TRAP1 and the major mitochondria deacetylase sirtuin-3 (SIRT3) in glioma stem cells (GSC) increases mitochondrial respiratory capacity and reduces production of reactive oxygen species. This metabolic regulation endowed GSCs with metabolic plasticity, facilitated adaptation to stress (particularly reduced nutrient supply), and maintained "stemness." Inactivation of TRAP1 or SIRT3 compromised their interdependent regulatory mechanisms, leading to metabolic alterations, loss of stemness, and suppression of tumor formation by GSC in vivo. Thus, targeting the metabolic mechanisms regulating interplay between TRAP1 and SIRT3 may provide a novel therapeutic option for intractable patients with GBM. SIGNIFICANCE: Discovery and functional analysis of a TRAP1-SIRT3 complex in glioma stem cells identify potential target proteins for glioblastoma treatment.
Abstract 11918: Lipoprotein(a) Predicts Subclinical Atherosclerosis in HIV-infected Young Women in the Women’s Interagency HIV Study
Authors: Byambaa Enkhmaa, Erdembileg Anuurad, Wei Zhang, Chin-Shang Li, Robert Kaplan, Jason Lazar, Dan Merenstein, Roksana Karim, Brad Aouizerat, Mardge Cohen, Kenneth Butler, Savita Pahwa, Igho Ofotokun, Adaora A Adimora, Elizabeth Golub, Lars Berglund
Journal: Circulation (2016)

Background/Objectives: Lipoprotein(a), Lp(a), is an independent causal risk factor for cardiovascular disease (CVD), where levels are regulated by the apolipoprotein(a), apo(a), gene. HIV-infected individuals are at significantly elevated CVD risk compared to HIV-uninfected individuals. The role of Lp(a) in HIV-related CVD remains unclear. We investigated the association between Lp(a) level, apo(a) size polymorphism and subclinical atherosclerosis in HIV-infected and HIV-uninfected women in the Women’s Interagency HIV Study. Methods: Lp(a) level, apo(a) size polymorphism and common carotid artery intima-media thickness (cIMT) were determined in 150 HIV-infected and 100 HIV-uninfected women. Lp(a) levels were square-root transformed to achieve normality. Linear regression models were used to evaluate the association of Lp(a) with cIMT adjusting for confounders. Results: The mean ages for the HIV+ and HIV- groups were 31 ± 4 and 30 ± 4 years, respectively. The majority of women were African-Americans (69% and 76% in the HIV+ and HIV- group, respectively). HDL-cholesterol, triglyceride and Lp(a) levels were significantly lower in the HIV+ vs. HIV- group. Prevalence of atherogenic small size apo(a) (&lt;22 Kringles) was ~20% in both groups. Notably, Lp(a) level was predictive of cIMT in the HIV+ group [β = 0.00541, 95% CI = (0.000608, 0.010212), p =0.029], but not in the HIV- group [β = 0.00175, 95% CI = (-0.0045024, 0.0080024), p =0.584]. After accounting for confounders (age, race, smoking, BMI, blood pressure, HCV co-infection, menopause, blood lipids, treatment status, CD4+ T-cell count, and HIV/RNA viral load), the association remained significant [β = 0.00532, 95% CI = (0.0000672, 0.0105728), p =0.049] in the HIV+ group. Conclusions: Lp(a) level is associated with subclinical atherosclerosis in young HIV-infected women. Further research is needed to identify mechanisms underlying Lp(a)-associated increased CVD risk in HIV-infected individuals.
Abstract B012: Histone demethylase JMJD1A promotes the generation of androgen receptor variant 7 (AR-V7) in prostate cancer cells
Authors: Lingling Fan, Fengbo Zhang, Ladan Fazli, Martin Gleave, Xuesen Dong, Jianfei Qi
Journal: Cancer Research (2018)

Abstract Generation of androgen receptor (AR) splicing variant, AR-V7, has been shown to contribute to the resistance of prostate cancer to androgen deprivation therapy and development of castration-resistant prostate cancer (CRPC). We and others have reported that histone demethylase JMJD1A promotes the transcriptional activity of AR by functioning as an AR coactivator. Here, we identified a new role for JMJD1A in the generation of AR-V7 in prostate cancer cells through interaction with HNRFPF. Knockdown of JMJD1A or HNRNPF reduced the mRNA and protein level of AR-V7 but had little effect on the full-length AR (AR-FL). Mechanistically, we found that JMJD1A and HNRNPF cooperatively bound to a polyG motif adjacent to the 5′ splicing site of Exon3b of AR gene, where they promoted the assembly of splicesome. Re-expression of AR-V7 in the JMJD1A-knockdown cells partly rescued the growth defect of prostate cancer cells in vitro and in the mouse xenograft model. The staining of AR-V7 paralleled that of JMJD1A or HNRNFP in a human prostate cancer tissue microarray. Together, our data reveal that JMJD1A enhances the castration-resistant growth of prostate cancer cells through coactivation of AR-FL and generation of AR-V7. Citation Format: Lingling Fan, Fengbo Zhang, Ladan Fazli, Martin Gleave, Xuesen Dong, Jianfei Qi. Histone demethylase JMJD1A promotes the generation of androgen receptor variant 7 (AR-V7) in prostate cancer cells [abstract]. In: Proceedings of the AACR Special Conference: Prostate Cancer: Advances in Basic, Translational, and Clinical Research; 2017 Dec 2-5; Orlando, Florida. Philadelphia (PA): AACR; Cancer Res 2018;78(16 Suppl):Abstract nr B012.
Abstract 474: Combined Polyphenols Synergistically Inhibit Tumor Necrosis Factor-alpha-Induced Monocytes Adhesion to Human Endothelial Cells
Authors: Lijuan Zhang, Xiaoyong Wang, Hongwei Si
Journal: Circulation Research (2017)

Monocyte recruitment and adhesion to the endothelium is a crucial step the development of endothelial dysfunction and therefore induces cardiovascular disease (CVD), the number one killer of Americans. Emerging evidence shows that polyphenols, the secondary plant metabolites present in a large variety of foods, have the potential ability in reducing risk of CVD. The aims of this study are to investigate the synergistic anti-inflammatory effects of combined polyphenols at physiological levels and define relevant molecular mechanisms. Our results indicate that resveratrol, curcumin and luteolin dose-dependently inhibited tumor necrosis factor-alpha (TNF-α)-induced monocytes adhesion to human endothelial cells. The half maximal effective concentration (EC50) values of curcumin, luteolin and resveratrol are 15 μM, 8 μM and 26 μM respectively. Particularly, combined luteolin (4μM) and curcumin (8 μM) or combination of curcumin (8 μM) and resveratrol (13 μM) synergistically inhibited TNF-α-induced monocytes adhesion to endothelial cells while the individual chemicals did not have such effect at the physiological concentrations. The combination index(CI)value of curcumin plus luteolin and curcumin plus resveratrol at the selected concentrations are 0.7 and 0.82, respectively, indicating these two combinations have synergistic anti-inflammatory effects. We also found that these phytochemicals ameliorated the TNF-α-enhanced protein expressions of vascular cell adhesion molecule 1 (VCAM-1) and monocyte chemotactic protein-1 (MCP-1), two major indicators of vascular inflammation in endothelial cells. These data suggest that these combined polyphenols maybe a novel strategy to diminish vascular inflammation and therefore prevent/treat cardiovascular disease.
What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands
Authors: Ahmed M. Elmansi, Mohamed E. Awad, Nada H. Eisa, Dmitry Kondrikov, Khaled A. Hussein, Alexandra Aguilar-Pérez, Samuel Herberg, Sudharsan Periyasamy-Thandavan, Sadanand Fulzele, Mark W. Hamrick, Meghan E. McGee-Lawrence, Carlos M. Isales, Brian F. Volkman, William D. Hill
Journal: Pharmacology & Therapeutics (2019)
Abstract 17447: Decreasing LV Torsion Rate Causes Inter-Ventricular Mechanical De-coupling and Thereby Disrupts RV Function in Pediatric Pulmonary Hypertension
Authors: Vitaly O Kheyfets, Melanie Dufva, Dunbar Ivy, Robin Shandas, Uyen Truong
Journal: Circulation (2017)

Introduction: Pulmonary Arterial Hypertension (PAH) is a disease characterized by progressively declining RV function. While RV contraction relies on mechanical energy transferred from the left ventricle (LV), little research has been devoted to the role of the LV in RV functional decline. Hypothesis: (1) LV torsion-rate is significantly decreased in children with PAH, which is correlated with decreasing RV contractility; and (2) decreased LV torsion-rate is a cause of decreased RV contractility. Methods: To address the first objective, tagged MRI of 19 pediatric PAH patients and 15 age-matched controls were prospectively obtained to measure LV torsion-rate in systole. For the PAH cohort, right heart catheterization was acquired within 2 days of MRI to measure RV contractility (as end-systolic elastance) using the single-beat method. To address the second objective, a bi-ventricular computational model was developed to assess the impact of LV torsion-rate on RV contractile function if the RV was passive d...
Maintenance Treatment with Lenalidomide for Multiple Myeloma Increases the Proportion of MRD Negative (Flow-/PET-CT-) Patients
Authors: Rafael Alonso Fernández, María Teresa Cedena, Rafael Rios, Javier Lopez Jimenez, Alejandro Sanz, Fernando Martín, Antonio Valeri, Juan Jose Lahuerta, Joaquin Martínez-López
Journal: Blood (2017)
Adjuvant HIPEC in patients with colon cancer at high risk of peritoneal metastases: Primary outcome of the COLOPEC multicenter randomized trial.
Authors: Charlotte Emma Louise Klaver, Daniel D Wisselink, Cornelis J. A. Punt, Petur Snaebjornsson, Johannes Crezee, Arend Aalbers, Willem A Bemelman, Alexandra Brandt, Andre Bremers, Jacobus W.A. Burger, Wilhelmina M.U. van Grevenstein, Patrick H.J. Hemmer, Ignace H.J.T. de Hingh, Niels Kok, Jurriaan Tuynman, Marinus J. Wiezer, Johannes H. W. de Wilt, Marcel G Dijkgraaf, Pieter J. Tanis
Journal: Journal of Clinical Oncology (2019)

482 Background: Patients with T4 or perforated colon cancer are at high risk (~25%) of peritoneal metastases (PM). Sensitivity of imaging modalities for PM is limited and the majority of patients is diagnosed in a palliative setting. This provides a rationale for adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC). In this study, the effectiveness of adjuvant HIPEC in reducing the risk of PM was determined. Methods: In this multicenter trial, patients with T4 (either cT4 or pT4, N0-2, M0) or perforated colon cancer, who underwent curative resection were randomized to adjuvant HIPEC followed by routine adjuvant systemic chemotherapy or to adjuvant systemic chemotherapy alone (1:1). Adjuvant HIPEC with oxaliplatin was performed simultaneously (9%) or within five-eight weeks (91%) after the primary tumor resection. Patients without evidence of recurrent disease at 18 months based on CT imaging underwent diagnostic laparoscopy in both arms. The primary endpoint was PM free survival (PMFS) at 18 months using Kaplan Meier analysis. Results: Between April 2015 and January 2017, 204 patients were randomized: 102 in the control arm (0 drop-outs), 102 in the experimental arm (two drop-outs). Surgical exploration at the start of the HIPEC procedure at five-eight weeks postoperatively revealed metastases in 11 patients (PM in 9/11) in the experimental arm, and adjuvant HIPEC was not applied. Adjuvant systemic chemotherapy was administered in 89/100 eligible patients after median 6 weeks (IQR 5-7) in the control arm and in 84/89 after 10 weeks (IQR 9-12) in the experimental arm. PM rate after completion of 18 months follow-up was 22/102 and 18/100, respectively. In the ITT analysis no difference in 18 months PMFS was observed: 77% (control) versus 81% (experimental), HR 0.836 (0.489-1.428)). Also, no differences were observed in 18 months DFS (HR 1.016 (0.646-1.598)) and OS (HR 1.139 (0.532-2.439)). One patient developed encapsulating peritoneal sclerosis after HIPEC. Conclusions: Adjuvant HIPEC with oxaliplatin for patients with T4 or perforated colon cancer does not result in improved 18 months PMFS. Long-term results have to be awaited to assess the role of HIPEC in the adjuvant setting. Clinical trial information: NCT02231086.
Diagnosis of disorders of glucose tolerance in women with polycystic ovary syndrome (PCOS) at a tertiary care center: fasting plasma glucose or oral glucose tolerance test?
Authors: Andrés E Ortiz-Flores, Manuel Luque-Ramírez, Elena Fernández-Durán, Francisco Alvarez-Blasco, Héctor F Escobar-Morreale
Journal: Metabolism (2019)
Early detection of lower GI tract tumors by dedicated assessment of the colon on routine computed tomography (CT) imaging: An observational study.
Authors: John Chang, Russell Pluhm, Ashley Lutrick, Jessica Guerra, Phillip Koo, Madappa N. Kundranda
Journal: Journal of Clinical Oncology (2019)

510 Background: We have previously reported that up to 48% of the early features of colorectal cancer (subtle wall thickening, pericolonic stranding, and small lymph nodes in the draining nodal station) were not identified on the original CT abdomen and pelvis (CTAP) reports. This resulted in a 36% decrease in five-year survival based on historical data. In this report, we assessed whether dedicated assessment of the colon on routine CT scans could lead to early detection of colorectal cancer. Methods: 210 CTAPs over a three-month period were screened from the emergency room records at a tertiary care hospital. 194 scans met eligibility. Exclusion criteria included: cases known to the evaluating radiologist and age ≤ 19 or &gt; 89 years. No study was excluded for suboptimal image quality. The original report was reviewed for abnormalities involving the colon, mesentery and bowel and was recorded. A blinded evaluation of the eligible case was then performed by a board-certified radiologist with attention specifically to the colon and the mesentery for the suspicious early features of CRC. The concordance and discordance was then tabulated. Discordant findings were re-evaluated to determine if the discordance was true. Results: 72/194 patients were male, median age 44.5 years (range 20 - 89). 55/194 patients (29.1%) included in the study were noted to have suspicious features. 26 had abnormal lymph nodes, 24 had abnormal colonic wall thickening and 16 had pericolonic stranding and/or wall edema. 45/55 studies were truly discordant from the original interpretation. These included one missed colorectal cancer (confirmed), one likely small bowel neuroendocrine tumor (no follow up), and one likely transitional cell carcinoma of the right renal pelvis (no follow up). Conclusions: Dedicated search of the colon and mesentery on CTAP can identify subtle findings, although their true relevance is being evaluated in a larger future study. Our observational data does indicate that there maybe a potential role for a focused evaluation of the colon and mesentery on routine CTAP in an attempt to potentially increase the rate of cancer detection especially in younger low-average risk patients.
Distinct patterns of bacterial vertical transmission from the maternal vaginal tract to infant gut microbiota
Authors: Kathryn McCauley, Juliana Durack, Douglas Fadrosh, Kole Lynch, Ariane Panzer, Kathrine L. Barnes, Casper G. Bendixsen, Kyra J. Jones, Christine Cole Johnson, Dennis R. Ownby, Edward M. Zoratti, Christine M. Seroogy, James E. Gern, Susan V. Lynch
Journal: Journal of Allergy and Clinical Immunology (2019)
Impact of Early Progression on Long Term Outcomes Among Myeloma Patients Receiving Lenalidomide, Bortezomib, and Dexamethasone (RVD) Induction Therapy
Authors: Ajay K Nooka, Jonathan L Kaufman, Charise Gleason, Nisha Joseph, Craig C Hofmeister, Lawrence H. Boise, Leonard Heffner, Madhav V Dhodapkar, Sagar Lonial
Journal: Blood (2018)
Evaluation Of Clinical Changes In Pediatric Patients With Atopic Dermatitis And Respiratory Allergy Receiving Allergen-specific Immunotherapy
Authors: Cindy Elizabeth de Lira-Quezada, Alfredo Arias Cruz, Sandra N. González Diaz, David Eugenio Roman Canamar, Rosalaura Villarreal Gonzalez, Daniel Sanchez-Guerra
Journal: Journal of Allergy and Clinical Immunology (2019)
Phase I Study of Palbociclib Alone and in Combination in Patients with Relapsed and Refractory (R/R) Leukemias
Authors: Tapan M. Kadia, Marina Y. Konopleva, Guillermo Garcia-Manero, Christopher B. Benton, William G. Wierda, Prithviraj Bose, Musa E. Yilmaz, Elias J. Jabbour, Steven M. Kornblau, Kapil N. Bhalla, Naveen Pemmaraju, Nitin Jain, Rashmi Malla, Gautam Borthakur, Jorge E. Cortes, Farhad Ravandi, Hagop M. Kantarjian
Journal: Blood (2018)
m6A Maintains Hematopoietic Stem and Progenitor Cell Identity
Authors: Yuanming Cheng, Hanzhi Luo, Franco Izzo, Brian F Pickering, Ly P Vu, Alexandra Schurer, Saroj Gourkanti, Samie R. Jaffrey, Dan A. Landau, Michael G. Kharas
Journal: Blood (2018)
The Global Syndemic of Obesity, Undernutrition, and Climate Change: The Lancet Commission report
Authors: Boyd A Swinburn, Vivica I Kraak, Steven Allender, Vincent J Atkins, Phillip I Baker, Jessica R Bogard, Hannah Brinsden, Alejandro Calvillo, Olivier De Schutter, Raji Devarajan, Majid Ezzati, Sharon Friel, Shifalika Goenka, Ross A Hammond, Gerard Hastings, Corinna Hawkes, Mario Herrero, Peter S Hovmand, Mark Howden, Lindsay M Jaacks, Ariadne B Kapetanaki, Matt Kasman, Harriet V Kuhnlein, Shiriki K Kumanyika, Bagher Larijani, Tim Lobstein, Michael W Long, Victor K R Matsudo, Susanna D H Mills, Gareth Morgan, Alexandra Morshed, Patricia M Nece, An Pan, David W Patterson, Gary Sacks, Meera Shekar, Geoff L Simmons, Warren Smit, Ali Tootee, Stefanie Vandevijvere, Wilma E Waterlander, Luke Wolfenden, William H Dietz
Journal: The Lancet (2019)
Abstract 20532: Ticagrelor and Adenosine Reuptake Blockade
Authors: Alfredo Gamboa, Rocio Figueroa, Jorge Celedonio, Italo Biaggioni
Journal: Circulation (2017)

Introduction: Ticagrelor, a P2Y12 antagonist approved for the treatment of coronary disease, also blocks adenosine reuptake, and potentiation of adenosine actions may contribute to its unique pleiotropic beneficial effects (improved cardiovascular mortality) and side effects (dyspnea, asymptomatic ventricular pauses). Hypothesis: Because the clinical relevance of this effect is unclear, we used the isolated forearm model to test the hypothesis that ticagrelor blocks adenosine reuptake, taking advantage of the fact that the vascular wall expresses high affinity nucleoside transporters that provide a barrier to transfer of adenosine from the intravascular compartment to the underlying interstitium. Methods: We infused intrabrachial adenosine 0.125 mg/min and measured vasodilation (forearm blood flow, FBF) and dialysate concentrations of adenosine ([Ado]) from a microdialysis probe inserted in the underlying muscle, in 3 groups of normal subjects before and 2 hrs after oral administration of placebo, the ade...
Deletion of the p53 Target Gene PUMA Prevents Bone Marrow Failure in a Dyskeratosis Congenita Mouse Model
Authors: Miriam Erlacher, Christian Molnar, Julia Miriam Weiss, Sheila Bohler, Doris Steinemann, Gudrun Göhring, Andreas Villunger, Verena Labi, Charlotte Niemeyer, Alexander Egle
Journal: Blood (2018)
Assisted dying: terminally ill man urges UK law change after police investigate his plans
Authors: Susan Mayor
Journal: BMJ (2019)

A terminally ill man with motor neurone disease has urged MPs to change the law to allow assisted dying in the UK in an open letter sent on the day of his assisted death in Switzerland, in which he recounted the distress caused to him and his family during a police investigation.1

Geoffrey Whaley, 80, was given a diagnosis of motor neurone disease in 2016. With no legal option of assisted dying in the UK, he decided to travel to Dignitas in Switzerland to end his life. But several weeks before his scheduled journey he …
Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction
Authors: Qiaozhen Liu, Kuo Liu, Guizhong Cui, Xiuzhen Huang, Shun Yao, Wenke Guo, Zhen Qin, Yan Li, Rui Yang, Wenjuan Pu, Libo Zhang, Lingjuan He, Huan Zhao, Wei Yu, Muxue Tang, Xueying Tian, Dongqing Cai, Yu Nie, Shengshou Hu, Tao Ren, Zengyong Qiao, Hefeng Huang, Yi Arial Zeng, Naihe Jing, Guangdun Peng, Hongbin Ji, Bin Zhou
Journal: Nature Genetics (2019)
Measurable Residual Disease Assay with WT1 Expression in Acute Myeloid Leukemia Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation; Optimal Threshold, Time Points, and Candidates
Authors: Byung Sik Cho, GI June MIN, Heeje Kim, Seug Yun Yoon, Sung-Soo Park, Silvia Park, Seung-Ah Yahng, Young-Woo Jeon, Seung-Hwan Shin, Jae-Ho Yoon, Sung-Eun Lee, Ki-Seong Eom, Yoo-Jin Kim, Seok Lee, Chang-Ki Min, Seok-Goo Cho, Dong-Wook Kim, Jong-Wook Lee
Journal: Blood (2018)