Antipsychotics for Preventing Delirium in Hospitalized Adults
Authors: Esther S. Oh, Dale M. Needham, Lisa M. Wilson, Karen A. Robinson, Karin J. Neufeld
Journal: Annals of Internal Medicine (2020)

Letters3 March 2020Antipsychotics for Preventing Delirium in Hospitalized AdultsEsther S. Oh, MD, PhD, Dale M. Needham, MD, PhD, Lisa M. Wilson, ScM, Karen A. Robinson, PhD, and Karin J. Neufeld, MD, MPHEsther S. Oh, MD, PhDJohns Hopkins University School of Medicine, Baltimore, Maryland (E.S.O., D.M.N., K.A.R., K.J.N.)Search for more papers by this author, Dale M. Needham, MD, PhDJohns Hopkins University School of Medicine, Baltimore, Maryland (E.S.O., D.M.N., K.A.R., K.J.N.)Search for more papers by this author, Lisa M. Wilson, ScMJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland (L.M.W.)Search for more papers by this author, Karen A. Robinson, PhDJohns Hopkins University School of Medicine, Baltimore, Maryland (E.S.O., D.M.N., K.A.R., K.J.N.)Search for more papers by this author, and Karin J. Neufeld, MD, MPHJohns Hopkins University School of Medicine, Baltimore, Maryland (E.S.O., D.M.N., K.A.R., K.J.N.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L19-0755 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We understand the FI to be a measure of the statistical robustness of study results. Dr. Vargas and colleagues conclude that “analysis from robust trials confirms that second-generation antipsychotics may decrease the delirium incidence in surgical patients but that haloperidol had no effect on this outcome.” This is similar to the findings reported in our systematic review and our more comprehensive report that included subgroup analysis specifically for postoperative patients (1). Our systematic review included all studies that met the eligibility criteria regardless of sample size or the statistical significance of their findings. We graded the strength of ...References1. Neufeld KJ, Needham DM, Oh ES, et al. Antipsychotics for the Prevention and Treatment of Delirium. Comparative Effectiveness Review no. 219. (Prepared by the Johns Hopkins University Evidence-based Practice Center under contract no. 290-2015-00006-I-2.) AHRQ publication no. 19-EHC019-EF. Rockville: Agency for Healthcare Research and Quality; 2019. [PMID: 31509366] Google Scholar2. Owens DK, Lohr KN, Atkins D, et al. AHRQ series paper 5: grading the strength of a body of evidence when comparing medical interventions—Agency for Healthcare Research and Quality and the Effective Health-Care Program. J Clin Epidemiol. 2010;63:513-23. [PMID: 19595577] doi:10.1016/j.jclinepi.2009.03.009 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Johns Hopkins University School of Medicine, Baltimore, Maryland (E.S.O., D.M.N., K.A.R., K.J.N.)Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland (L.M.W.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M19-1859. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAntipsychotics for Preventing Delirium in Hospitalized Adults Esther S. Oh , Dale M. Needham , Roozbeh Nikooie , Lisa M. Wilson , Allen Zhang , Karen A. Robinson , and Karin J. Neufeld Antipsychotics for Preventing Delirium in Hospitalized Adults Maria Vargas , Pasquale Buonano , Annachiara Marra , Carmine Iacovazzo , and Giuseppe Servillo Metrics 3 March 2020Volume 172, Issue 5Page: 366KeywordsAntipsychoticsDeliriumDisclosureHealth care qualityHealth services researchResearch quality assessmentSystematic reviews ePublished: 3 March 2020 Issue Published: 3 March 2020 PDF downloadLoading ...