tbuckley/cabot-search huggingface dataset:
Factors associated with prolonged viral shedding and impact of lopinavir/ritonavir treatment in hospitalised non-critically ill patients with SARS-CoV-2 infection
Authors: Dan Yan, Xiao-Yan Liu, Ya-nan Zhu, Li Huang, Bi-tang Dan, Guo-jun Zhang, Yong-hua Gao
Journal: European Respiratory Journal (2020)

The duration of viral shedding is central to the guidance of decisions about isolation precautions and antiviral treatment. However, studies regarding the risk factors associated with prolonged shedding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the impact of lopinavir/ritonavir (LPV/r) treatment on viral shedding remain scarce.Data were collected from all SARS-CoV-2 infected patients who were admitted to isolation wards and had reverse transcription PCR conversion at the No. 3 People's Hospital of Hubei province, China, between 31 January and 9 March 2020. We compared clinical characteristics and SARS-CoV-2 RNA shedding between patients initiated with LPV/r treatment and those without. Logistic regression analysis was employed to evaluate the risk factors associated with prolonged viral shedding.Of 120 patients, the median age was 52 years, 54 (45%) were male and 78 (65%) received LPV/r treatment. The median duration of SARS-CoV-2 RNA detection from symptom onset was 23 days (interquartile range 18-32 days). Older age (OR 1.03, 95% CI 1.00-1.05; p=0.03) and the lack of LPV/r treatment (OR 2.42, 95% CI 1.10-5.36; p=0.029) were independent risk factors for prolonged SARS-CoV-2 RNA shedding. Patients who initiated LPV/r treatment within 10 days from symptom onset, but not initiated from day 11 onwards, had significantly shorter viral shedding duration compared with those without LPV/r treatment (median 19 days versus 28.5 days; log-rank p<0.001).Older age and the lack of LPV/r treatment were independently associated with prolonged SARS-CoV-2 RNA shedding in patients with coronavirus disease 2019 (COVID-19). Earlier administration of LPV/r treatment could shorten viral shedding duration.
Covid-19: are face masks a good long term strategy?
Authors: Sheung-Tak Cheng
Journal: BMJ (2020)

The HIV-1 protease inhibitor ritonavir (ABT-538) undergoes cytochrome P450-mediated biotransformation in human liver microsomes to three major metabolites, Ml, M2 and M11, with wide interindividual variation in the rates of metabolite formation. The structures of these metabolites were determined with the use of electrospray ionization mass spectrometry. Chemical inhibition, metabolic correlation, immunoinhibition and metabolism by microsomes derived from specific CYP cDNA-transfected B-lymphoblastoid cell lines indicated that the CYP3A subfamily of enzymes was the major contributor to the formation of M1 and M11, whereas both CYP3A and CYP2D6 contributed to the formation of M2. None of the typical CYP3A substrates/inhibitors (e.g., ketoconazole, troleandomycin) were able to completely inhibit ritonavir metabolism, even at high concentrations. Ritonavir was found to be a potent inhibitor of CYP3A-mediated biotransformations (nifedipine oxidation, IC50) = 0.07 microM; 17alpha-ethynylestradiol 2-hydroxylation, IC50 = 2 microM; terfenadine hydroxylation, IC50 = 0.14 microM). Ritonavir was also found to be an inhibitor of the reactions mediated by CYP2D6 (IC50 = 2.5 microM) and CYP2C9/10 (IC50 = 8.0 microM). The results of this study indicate the potential for in vivo inhibition of the metabolism by ritonavir of drugs that are CYP3A, CYP2D6 and, to a lesser extent, CYP2C9/10 substrates.
“All Our Wisdom is Stored in the Trees” - Degrading BCR-ABL with <i>Berberis Vulgaris</i>
Authors: Shannon Elisabeth Elf
Journal: Clinical Cancer Research (2020)

Abstract Treating BCR-ABL–positive chronic myeloid leukemia remains impeded by the development of clinical resistance to imatinib. It has been demonstrated that berberine, a plant alkaloid, has activity against imatinib-resistant BCR-ABL mutants by inducing autophagic degradation of BCR-ABL, thereby preventing the acquisition of drug-resistant mutations. See related article by Yin et al., p. 4040
Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 Diabetes
Authors: Nisa M. Maruthur, Eva Tseng, Susan Hutfless, Lisa M. Wilson, Catalina Suarez-Cuervo, Zackary Berger, Yue Chu, Emmanuel Iyoha, Jodi B. Segal, Shari Bolen
Journal: Annals of Internal Medicine (2016)

In this review, the authors delineate the comparative effectiveness and safety of metformin and metformin-based combinations, thiazolidinediones, sulfonylureas, DPP-4 inhibitors, sodium–glucose cot...
PANCREATIC ASCITES TREATED BY PANCREATIC STENT THROUGH MINOR PAPILLA BY EUS- GUIDED RENDEZVOUS
Authors: LM Prado, S Baile-Maxía, C Mangas-Sanjuán, M Bozhychko, JM Sempere, B Martínez, L Compañy, F Ruiz, JA Casellas, JR Aparicio
Journal: Endoscopy (2020)

30 years-old with acute alcoholic pancreatitis. Develops severe pancreatic ascites secondary to rupture of the pancreatic duct. It’s not possible to cannulate major papilla in ERCP and EUS is performed appreciating a pancreatic duct < 1 mm.
The UK’s public health response to covid-19
Authors: Gabriel Scally, Bobbie Jacobson, Kamran Abbasi
Journal: BMJ (2020)

The UK government and its advisers were confident that they were "well prepared" when covid-19 swept East Asia.The four-pronged plan of 3 March to contain, delay, research, and mitigate was supported by all UK countries and backed, they claimed, by science. 1 With over 30 000 hospital and community deaths by 12 May, where did the plan go wrong? 2 What was the role of public health in the biggest public health crisis since the Spanish flu of 1918?And what now needs to be done?What is clear is that the UK's response so far has neither been well prepared nor remotely adequate (see infographic).The weakness of the preparations was exposed in 2016 by Exercise Cygnus, a pandemic simulation, and the necessary remedial steps were not taken. 3On 30 January, the World Health Organization declared a public health emergency of international concern and governments were urged to prepare for global spread of covid-19 from East Asia. 4Detailed case studies followed showing the need for high levels of mechanical ventilation and high death rates. 5 6But the UK ignored these warnings. Delay and dilution
1-LITER POLYETHILENE GLYCOL (1L-PEG) BOWEL PREPARATION VS. 4L- PEG FOR COLON CLEANSING AMONG INPATIENTS: A PROPENSITY SCORE MATCHING ANALYSIS FROM A LARGE MULTICENTER PROSPECTIVE COHORT
Authors: L Frazzoni, C Spada, F Radaelli, A Mussetto, C Fabbri, L Laterza, M Manno, G Manes, S Piccirelli, ML Marca, G Aragona, S Cadoni, F Bazzoli, P Occhipinti, E Rondonotti, C Hassan, L Fuccio
Journal: Endoscopy (2020)

Aims The inpatient status is one of the strongest independent predictors for inadequate colon cleansing. The best strategy for bowel preparation among inpatients is yet unknown. Based on experts’ opinion, high-volume, 4L polyethilene glycol (PEG) solution should be the standard-of-care in this setting. We aimed to determine whether the novel 1L-PEG plus ascorbate prep is associated with increased colon cleansing among inpatients.
EFFECT OF BOWEL PREPARATION ON RENAL FUNCTION IN PATIENTS WITH AND WITHOUT CHRONIC KIDNEY DISEASE – A RETROSPECTIVE AUDIT OF 1000 COLONOSCOPIES
Authors: BW Johnson, V Giljaca
Journal: Endoscopy (2020)

Aims Records for patients who underwent colonoscopy and who received a 2 L polyethylene glycol (PEG) bowel preparation were reviewed to evaluate whether there is any effect on renal function in those patients with chronic kidney disease (CKD) versus those without.
THE FIRST REAL-LIFE MULTICENTRE, PROSPECTIVE VALIDATION STUDY OF THE ELECTRONIC CHROMOENDOSCOPY SCORING SYSTEM (PICASSO-THE PADDINGTON INTERNATIONAL VIRTUAL CHROMOENDOSCOPY SCORE) AND ITS OUTCOME IN ULCERATIVE COLITIS
Authors: M Iacucci, S Smith, A Bazarova, U Shivaji, P Bhandari, R Cannatelli, M Daperno, JG Ferraz, M Goetz, X Gui, B Hayee, GD Hertogh, M Lazarev, J Li, OM Nardone, V Occhipinti, R Panaccione, A Parra-Blanco, L Pastorelli, T Rath, GE Tontini, M Vieth, V Villanacci, D Zardo, R Kiesslich, R Bisschops, S Ghosh
Journal: Endoscopy (2020)

Aims Mucosal healing is an important goal in the treatment of ulcerative colitis (UC). The newly published PICaSSO score characterises subtle mucosal and vascular changes and defines mucosal healing. We aimed to validate in real-life the PICaSSO score and assess its ability to predict relapse.
Tuberculosis, COVID-19 and migrants: Preliminary analysis of deaths occurring in 69 patients from two cohorts
Authors: I. Motta, R. Centis, L. D’Ambrosio, J.-M. García-García, D. Goletti, G. Gualano, F. Lipani, F. Palmieri, A. Sánchez-Montalvá, E. Pontali, G. Sotgiu, A. Spanevello, C. Stochino, E. Tabernero, M. Tadolini, M. van den Boom, S. Villa, D. Visca, G.B. Migliori
Journal: Pulmonology (2020)

Little is known about the relationship between the COVID-19 and tuberculosis (TB). The aim of this study is to describe a group of patients who died with TB (active disease or sequelae) and COVID-19 in two cohorts. Data from 49 consecutive cases in 8 countries (cohort A) and 20 hospitalised patients with TB and COVID-19 (cohort B) were analysed and patients who died were described. Demographic and clinical variables were retrospectively collected, including co-morbidities and risk factors for TB and COVID-19 mortality. Overall, 8 out of 69 (11.6%) patients died, 7 from cohort A (14.3%) and one from cohort B (5%). Out of 69 patients 43 were migrants, 26/49 (53.1%) in cohort A and 17/20 (85.0%) in cohort B. Migrants: (1) were younger than natives; in cohort A the median (IQR) age was 40 (27–49) VS. 66 (46–70) years, whereas in cohort B 37 (27–46) VS. 48 (47–60) years; (2) had a lower mortality rate than natives (1/43, 2.3% versus 7/26, 26.9%; p-value: 0.002); (3) had fewer co-morbidities than natives (23/43, 53.5% versus 5/26–19.2%) natives; p-value: 0.005). The study findings show that: (1) mortality is likely to occur in elderly patients with co-morbidities; (2) TB might not be a major determinant of mortality and (3) migrants had lower mortality, probably because of their younger age and lower number of co-morbidities. However, in settings where advanced forms of TB frequently occur and are caused by drug-resistant strains of M. tuberculosis, higher mortality rates can be expected in young individuals.
The Financial Effect of Value-Based Purchasing and the Hospital Readmissions Reduction Program on Safety-Net Hospitals in 2014
Authors: Matlin Gilman, Jason M. Hockenberry, E. Kathleen Adams, Arnold S. Milstein, Ira B. Wilson, Edmund R. Becker
Journal: Annals of Internal Medicine (2020)

This cohort study aimed to determine whether safety-net hospitals incur larger financial penalties than other hospitals under value-based purchasing and the Hospital Readmissions Reduction Program.
Treatment costs of breast cancer among younger women aged 19 to 44 years enrolled in Medicaid.
Authors: Donatus U. Ekwueme, Benjamin T. Allaire, Gery Guy, Sarah Arnold, Justin G Trogdon
Journal: Journal of Clinical Oncology (2015)

74 Background: Breast cancer is the most common malignant tumor among women in the United States, accounting for about 30% of incident cancers. It is one of the most costly medical conditions to treat. Younger women aged 18-44 years account for 11% of new cases. These women tend to experience more aggressive types of breast cancer, requiring intensive and expensive treatment. In recent years, a few studies have examined the costs of breast cancer treatment in a Medicaid population at the state level. However, no study has estimated medical costs for breast cancer treatment at the national level for women aged 19-44 years enrolled in Medicaid. Methods: A sample of 5,542 younger women aged 19-44 years, fee-for-service Medicaid enrollees, and diagnosed with breast cancer in 2007 were compared with 4.3 million women aged 19-44 years, fee-for-service Medicaid enrollees, but without breast cancer. The study used linear and nonlinear regression methods to estimate treatment costs for younger women with breast cancer compared with those without breast cancer. Individual medical costs were estimated by race/ethnicity and by type of services. All medical treatment costs were adjusted to 2010 dollars. Results: The estimated annual direct medical costs for breast cancer treatment among younger women enrolled in Medicaid ranged from nearly $25,000 to $42,000 per woman. Non-Hispanic black women had the highest annual total medical costs, followed by Hispanic women, while non-Hispanic women of other race had the lowest. The cost estimates ranged from $14,600 to $18,800 for outpatient service, $4,600 to $5,700 for inpatient service, and $3,500 to $4,800 for prescription drugs. Conclusions: The cost estimates demonstrate the substantial medical costs associated with breast cancer treatment for younger Medicaid beneficiaries. As the Medicaid program continues to evolve, the treatment cost estimates could serve as important inputs in decision-making regarding planning for treatment of invasive breast cancer in this population.
ARE GI CANCERS BEING DIAGNOSED FROM OUTSIDE THE ´URGENT CANCER´ REFERRAL PATHWAY?
Authors: RN Patel, A Mehta, S Hong, A Sachdeva, K Besherdas
Journal: Endoscopy (2020)

Aims The UK lags behind Europe in the diagnosis of cancer. Patients with alarm symptoms are referred on a ´Two week wait´ (2WW) urgent pathway. We aimed to study the diagnostic pathways via which GI cancers are diagnosed.
A RARE CASE OF BILIARY STRICTURE - EUS GUIDED FINE NEEDLE BIOPSY FOR THE DIAGNOSIS OF HIV RELATED CHOLANGIOPATHY
Authors: MG Haba, BA Castillo, GT Vázquez Benitez, AD de Santiago, FP Renedo, PI Arevalo, JLC Panero
Journal: Endoscopy (2020)

A 45 years old male, recently diagnosed of HIV / AIDS, is admitted due to infectious bronchiolitis, severe immune suppression and cholestasis. MRI demonstrates an intrapancreatic biliary stricture raising concern of cholangiocarcinoma.
ENDOBILIARY RADIOFREQUENCY ABLATION FOR REFRACTORY BENIGN STRICTURE: AN EUROPEAN PILOT STUDY
Authors: J Privat, H Demmak, B Aly
Journal: Endoscopy (2020)

Aims Endoscopic treatment of benign biliary stricture (BBS) remains challenging with 15% of recurrence ater metallic or multiple plastic stenting. We experimented endobiliary radiofrequency ablation (ERFA) with the aim to eradicate biliary fibroplasia endoscopically. We report our first experience of ERFA in the management of refractory BBS.
EFFECTIVENESS AND SAFETY OF LAPAROSCOPY-ASSISTED TRANSGASTRIC ENDOSCOPIC RETROGRADE CHOLANGIOGRAPHY IN A LARGE POPULATION OF PATIENTS WITH ROUX-AND-Y GASTRIC BYPASS
Authors: L Koggel, M Groenen, B Witteman, R Robijn, P Wahab, JM Vrolijk
Journal: Endoscopy (2020)

Aims Conventional endoscopic retrograde cholangiopancreaticography (ERCP) is anatomically challenging in patients with a Roux-and-Y gastric bypass (RYGB). Laparoscopic-assisted transgastric endoscopic retrograde cholangiography (LAERC) is an alternatives as it allows access to the biliary tree via the gastric remnant. We investigated the effectiveness and safety of LAERC in patients with a RYGB.
ENDOSCOPIC MANAGEMENT OF POST-OPERATIVE ANASTOMOTIC LEAKAGE OR FISTULA AFTER ESOPHAGOGASTRIC RESECTION FOR MALIGNANCY: A FRENCH MULTICENTER EXPERIENCE
Authors: R Hallit, M Calmels, U Chaput, D Lorenzo, A Becq, M Camus, X Dray, JM Gonzalez, M Barthet, J Jacques, R Legros, P Cattan, A Belle, S Chaussade, R Coriat, F Prat, D Goere, M Barret
Journal: Endoscopy (2020)

Aims Esophagectomy remains the standard care for a vast proportion of esophageal or esophagogastric lesions.This procedure is associated in 10% of cases with anastomotic fistulas. Endoscopic management of post-operative anastomotic complications has been mostly reported with esophageal stents.Recently, internal drainage by double pigtail stents has been introduced for managing these complications.Our aim was to assess the overall efficacy of the endoscopic treatment for anastomotic leaks after esophagogastric resection for cancer.
COLON POLYP DETECTION USING LINKED COLOR IMAGING COMPARED TO WHITE LIGHT IMAGING: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: S Shinozaki, Y Kobayashi, Y Hayashi, H Sakamoto, K Sunada, A Lefor, H Yamamoto
Journal: Endoscopy (2020)

Aims Linked color imaging (LCI) is a novel image enhancing technology which enhances color differences between a colon lesion and surrounding mucosa with enough brightness to illuminate the wide colorectal lumen. The aim of this study is to compare colorectal polyp detection using LCI with white light imaging (WLI).
Glucocorticoids enhance the antileukemic activity of FLT3 inhibitors in FLT3-mutant acute myeloid leukemia
Authors: Melat T. Gebru, Jennifer M. Atkinson, Megan M. Young, Lijun Zhang, Zhenyuan Tang, Zhenqiu Liu, Pinyi Lu, Christopher M. Dower, Longgui Chen, Charyguly Annageldiyev, Arati Sharma, Yuka Imamura Kawasawa, Zhongming Zhao, Barbara A. Miller, David F. Claxton, Hong-Gang Wang
Journal: Blood (2020)
LITHOLAPAXY IN INDIA.
Authors: D F Keegan
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Obesity Is a Risk Factor for Greater COVID-19 Severity
Authors: Feng Gao, Kenneth I. Zheng, Xiao-Bo Wang, Qing-Feng Sun, Ke-Hua Pan, Ting-Yao Wang, Yong-Ping Chen, Giovanni Targher, Christopher D. Byrne, Jacob George, Ming-Hua Zheng
Journal: Diabetes Care (2020)

Figure 1-A: Prevalence of clinical subtypes of COVID-19 severity among infected patients with and without obesity.B: Association between increasing BMI
Toxoplasmic Encephalitis in Patients with the Acquired Immunodeficiency Syndrome
Authors: Benjamin J. Luft, Richard Hafner, Ann H. Korzun, Catherine Leport, Diana Antoniskis, Elizabeth M. Bosler, D. David Bourland, Raj Uttamchandani, Jack Fuhrer, Jeffrey Jacobson, Philippe Morlat, Jean-Louis Vilde, Jack S. Remington
Journal: New England Journal of Medicine (1993)

In patients with the acquired immunodeficiency syndrome (AIDS), toxoplasmic encephalitis is usually a presumptive diagnosis based on the clinical manifestations, a positive antitoxoplasma-antibody titer, and characteristic neuroradiologic abnormalities. A response to specific therapy helps to confirm the diagnosis, but it is unclear how rapid the response should be. We studied the course of patients treated for acute toxoplasmic encephalitis and evaluated objective clinical criteria for this empirical diagnosis.
OPTIMIZING OUTCOMES OF TISSUE ACQUISITION FOR DIAGNOSIS OF BILIARY LESION IN ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY
Authors: S Kim, HS Lee, KW Lee, S Jang, SH Kim, HJ Jeon, SJ Choi, JM Lee, HS Choi, ES Kim, B Keum, YT Jeen, CD Kim, CH Oh, SH Dong
Journal: Endoscopy (2020)

Aims Accurate diagnosis of biliary lesions remains a clinical challenge due to the difficulty of obtaining an adequate specimen. Bile aspiration, brush cytology and forcep biopsy are well-known methods of obtaining tissue in endoscopic retrograde cholangiopancreatography(ERCP). Recently, single-use cholangioscopy(Spyglass, Boston scientific, USA) has been developed to improve diagnostic capability of ERCP. This study is aimed to compare the performance of each method and optimize the strategy for biliary tissue sampling.
Tofacitinib in Combination With Nonbiologic Disease-Modifying Antirheumatic Drugs in Patients With Active Rheumatoid Arthritis
Authors: Joel Kremer, Zhan-Guo Li, Stephen Hall, Roy Fleischmann, Mark Genovese, Emilio Martin-Mola, John D. Isaacs, David Gruben, Gene Wallenstein, Sriram Krishnaswami, Samuel H. Zwillich, Tamas Koncz, Richard Riese, John Bradley
Journal: Annals of Internal Medicine (2013)

Many patients with rheumatoid arthritis have an inadequate response to disease-modifying antirheumatic drugs. This randomized trial of patients with rheumatoid arthritis and an inadequate response ...
BYL719, a next generation PI3K alpha specific inhibitor: Preliminary safety, PK, and efficacy results from the first-in-human study
Authors: D Juric, J Rodon, A M Gonzalez-Angulo, H A Burris, J Bendell, J D Berlin, M R Middleton, D Bootle, M Boehm, A Schmitt, N Rouyrre, C Quadt, J Baseiga
Journal: Cancer Research (2012)
NOVEL METHOD TO ASSESS COLD SNARE POLYPECTOMY QUALITY FOR 1-10 MM COLORECTAL POLYPS - MEASURING THE MINIMUM EXTENT OF A HEALTHY RESECTION MARGIN
Authors: H Pohl, D von Renteln, A Aguilera-Fish, JC Anderson
Journal: Endoscopy (2020)

Aims Measuring quality of polypectomy in clinical practice remains a challenge. We examined the extent of a normal healthy tissue margin around neoplastic tissue of the resected polyp specimen as a potential quality measure for polypectomy.
SMALL BOWEL CAPSULE ENDOSCOPY: THERAPEUTIC IMPACT AND RESEARCH FOR PREDICTIVE FACTORS OF THERAPEUTIC YIELD IN IRON DEFICIENCY ANEMIA WITH OR WITHOUT OVERT DIGESTIVE BLEEDING
Authors: Y Chapelain, T Collet, S Viennot
Journal: Endoscopy (2020)

Aims Iron deficiency is the main cause of anemia. The recommendations provide for a small bowel capsule endoscopy (SBCE) in case of obscure gastro-intestinal bleeding (OGIB) with or without exteriorization after complete endoscopic assessment. The diagnostic yield is currently well defined in contrast to the therapeutic impact.
RHEUMATISM AND ARTHRITIS
Authors: Charley J. Smyth, Joseph J. Bunim, William S. Clark, Darrell C. Crain, Felix E. Demartini, Ivan F. Duff, Ephraim P. Engleman, Donald C. Graham, Max M. Montgomery, Bernard M. Norcross, Howard F. Polley, Marian W. Ropes, Edward F. Rosenberg
Journal: Annals of Internal Medicine (2020)

Excerpt CONTENTS PART I General Incidence of Rheumatic Diseases 2 Classification of Diseases of Joints and Related Structures 5 Diseases Primarily Related to Trauma 5 Arthritis Due to Specific Infe...
THE TIME OF ESOPHAGOGASTRODUDENOSCOPY IN RELATION TO EXAMINATION QUALITY MEASURES
Authors: M Romańczyk, T Romańczyk, M Lesińska, K Barański, M Hartleb, M Waluga
Journal: Endoscopy (2020)

Aims Esophagogastrodudenoscopy (EGD) is widely available endoscopy procedure that is not free from false-negative results, reaching up to 9.4% of cases in gastric cancer. Recently, two quality indicators of EGD were proposed: endoscopist biopsy rate (EBR) and composite detection rate (CDR - the sum of gastric inlet patches, gastric polyps and duodenal bulb deformations detection rates). It was also suggested that duration of EGD should not be shorter than 5 or 7 minutes or withdrawal time not less than 3 minutes. The aim of the study is to determine if proposed quality indicators reflect duration of the procedure.
PROPHYLACTIC ANTIBIOTICS IN THE PREVENTION OF INFECTION IN PATIENTS UNDERGOING ENDOSCOPIC RESECTION OF COLORECTAL LESIONS: A META-ANALYSIS
Authors: E John Aguila, S Edding, C Paolo Francisco, J Co, J Cervantes
Journal: Endoscopy (2020)

Aims Larger colorectal lesions tend to have a higher risk of infection after endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD), possibly because of the larger wound areas. There have been conflicting studies on prophylactic antibiotics in the prevention of infection in patients who underwent EMR or ESD.