AB0994 VITAMIN D STATUS IN CHILDREN WITH JIA DEPENDING ON THE SEASON
Authors: Natalia Shevchenko, Yulia Khadzhynova
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> Plenty of studies demonstrated the relationship between vitamin D and Juvenile idiopathic arthritis (JIA) disease activity<sup> [1,2]</sup>.Others reported no relationship between 25(OH)D and disease activity <sup>[3,4]</sup>. The main source of vitamin D is endogenous vitamin D synthesis induced by sunlight exposure. <h3>Objectives</h3> The aim of this study was to examine the status of vitamin D in children with JIA depending on the peculiarities of the disease and the season. <h3>Methods</h3> 92 patients with JIA were examined. The median age of them was 10,5±1,7 years, from 1,8 to 17,6 years (55 female, 37 male). The serum level of vitamin D was measured through blood test by chemiluminescence method. The relationship between the level of vitamin D and disease activity was analyzed based on juvenile arthritis disease activity score (JADAS27). <h3>Results</h3> The average level of vitamin D was 22,75±1,97ng/ml (corresponded to an insufficient level). It was not found relationship between the frequency of vitamin D deficiency and gender. Vitamin D status changed throughout the year from lowest value 19,52±1,61 ng/ml (in May) till the greatest value 29,62±2,49 ng/ml (in September). Significantly higher level of vitamin D was in September compared to most months (January, p=0,04; February, p=0,04; March, p=0,01; April, p=0,02; May, p=0,01; October, p=0,03; November, p=0,03; December, p=0,01). The geographical location of Kharkiv (Ukraine) is at 50<sup>o</sup> latitude. It was proved that UVB radiation above the 33° latitude is not intense enough for the synthesis of vitamin D during the whole year<sup> [5]</sup>. At the same time there was no significant relationship between the low level of vitamin D in serum and disease activity. <h3>Conclusion</h3> A decrease of vitamin D status were observed throughout the year. Despite the fact that in September was the highest level of vitamin D, the normal concentration was not reached. Seasons should be taken into account, but patients with JIA need supplementation of vitamin D all around the year. <h3>References</h3> [1] Szymańska-Kałuża J. Biernacka-ZielińskaM, Stańczyk J, Smolewska E. Vitamin D level in children with juvenile idiopathic arthritis and its correlation with clinical picture of the disease. Reumatologia. 2013;51:271–6. doi: 10.5114/reum.2013.37250. [2] çomak E, Doğan çS, Uslu-gökçeoğlu A, Akbaş H, özdem S. Association between vitamin D deficiency and disease activity in juvenile idiopathic arthritis. Turk J Pediatr. 2014;56:626–631. [3] Dağdeviren-çakır A, Arvas A, Barut K, Gür E, Kasapçopur ö. Serum vitamin D levels during activation and remission periods of patients with juvenile idiopathic arthritis and familial Mediterranean fever. Turk J Pediatr. 2016;58:125–31. doi: 10.24953/turkjped.2016.02.001. [4] Bouaddi I, Rostom S, El Badri D, Hassani A, Chkirate B, Abouqal R, et al. Vitamin D concentrations and disease activity in Moroccan children with juvenile idiopathic arthritis. BMC Musculoskelet Disord. 2014;15:115. doi: 10.1186/1471-2474-15-115. [5] Wacker M, Holick MF. Sunlight and vitamin D: a global perspective for health. Dermatoendocrinol. 2013;5:51–108. doi: 10.4161/derm.24494. <h3>Disclosure of Interests</h3> None declared