tbuckley/cabot-search huggingface dataset:
Combined Androgen Blockade in Localized Prostate Cancer Treated With Definitive Radiation Therapy
Authors: Lucas K. Vitzthum, Chris Straka, Reith R. Sarkar, Rana McKay, J. Michael Randall, Ajay Sandhu, James D. Murphy, Brent S. Rose
Journal: Journal of the National Comprehensive Cancer Network (2019)

Background: The addition of androgen deprivation therapy to radiation therapy (RT) improves survival in patients with intermediate- and high-risk prostate cancer (PCa), but it is not known whether combined androgen blockade (CAB) with a gonadotropin-releasing hormone agonist (GnRH-A) and a nonsteroidal antiandrogen improves survival over GnRH-A monotherapy. Methods: This study evaluated patients with intermediate- and high-risk PCa diagnosed in 2001 through 2015 who underwent RT with either GnRH-A alone or CAB using the Veterans Affairs Informatics and Computing Infrastructure. Associations between CAB and prostate cancer–specific mortality (PCSM) and overall survival (OS) were determined using multivariable regression with Fine-Gray and multivariable Cox proportional hazards models, respectively. For a positive control, the effect of long-term versus short-term GnRH-A therapy was tested. Results: The cohort included 8,423 men (GnRH-A, 4,529; CAB, 3,894) with a median follow-up of 5.9 years. There were 1,861 deaths, including 349 resulting from PCa. The unadjusted cumulative incidences of PCSM at 10 years were 5.9% and 6.9% for those receiving GnRH-A and CAB, respectively ( P =.16). Compared with GnRH-A alone, CAB was not associated with a significant difference in covariate-adjusted PCSM (subdistribution hazard ratio [SHR], 1.05; 95% CI, 0.85–1.30) or OS (hazard ratio, 1.02; 95% CI, 0.93–1.12). For high-risk patients, long-term versus short-term GnRH-A therapy was associated with improved PCSM (SHR, 0.74; 95% CI, 0.57–0.95) and OS (SHR, 0.82; 95% CI, 0.73–0.93). Conclusions: In men receiving definitive RT for intermediate- or high-risk PCa, CAB was not associated with improved PCSM or OS compared with GnRH alone.
Molecular Mechanisms Regulating Migration and Adhesion in Response to the Chemokine SDF-1 in Multiple Myeloma (MM).
Authors: Irene Ghobrial, Ujjal Singha, Yazan Alsayed, Alissa Huston, Lanie Francis, Ganwei Lu, Judy Anderson, Suzanne Lentzsch, G. David Roodman
Journal: Blood (2005)
Abstract 14193: Effect of Combining Low Levels of Tissue Factor With Complete Deficiencies in Either Factor Ix or Factor Xi on Development and Survival
Authors: Steven P Grover, Alyson Auriemma, Clare Schmedes, Emily Butler, Dougald Monroe, David Gailani, Rafal Pawlinski, Nigel Mackman
Journal: Circulation (2018)

Introduction: The coagulation cascade plays an essential role in hemostasis. The tissue factor (TF):factor VIIa (FVIIa) complex (extrinsic pathway) triggers and the intrinsic pathway (FXII, FXI, FI...
Efficacy and Tolerability of Nilotinib in Chronic Myeloid Leukemia Patients in Chronic Phase (CML-CP) Who Failed Prior Imatinib and Dasatinib Therapy: Updated Results of a Phase 2 Study
Authors: Francis Giles, Philipp D. le Coutre, Kapil N. Bhalla, Gert J Ossenkoppele, Giuliana Alimena, Ariful Haque, Neil J. Gallagher, Hagop M Kantarjian
Journal: Blood (2008)
Using Patient Preferences to Determine Noninferiority Margins in Trials—Reply
Authors: Sergio A. Acuna, Tyler R. Chesney, Nancy N. Baxter
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 12265: Downregulation of Endoplasmic Reticulum- Mitochondria Tethering Proteins in Monocrotaline-Induced Pulmonary Arterial Hypertension
Authors: Shunsuke Baba, Satoko Shinjo, Mariko Okada, Yoshitaka Fujimoto, Toru Akaike, Yoichiro Kusakari, Susumu Minamisawa
Journal: Circulation (2018)

Introduction and Objectives: Pulmonary hypertension (PH) is a lethal vascular disease. Although several vasoreactive drugs such as prostacyclin have improved its prognosis, the long-term outcome of...
Basophil activation testing, IgG, and IgG4 in the diagnosis of dog allergy in children with and without a dog at home
Authors: Ulrika Käck, Anna Asarnoj, Jonas Binnmyr, Hans Grönlund, Carina Wallén, Gunnar Lilja, Marianne van Hage, Anna Nopp, Jon R. Konradsen
Journal: Allergy (2019)

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Targeting CD20 and CD22 with Rituximab in Combination with CMC-544 Results in Improved Anti-Tumor Activity Against Non-Hodgkin’s Lymphoma (NHL) Pre-Clinical Models.
Authors: Francisco J. Hernandez-Ilizaliturri, Suresh Devineni, Sarika Arora, Joy Knight, Myron S. Czuczman
Journal: Blood (2005)
Prognostic Impact of MCPyV and TIL Subtyping in Merkel Cell Carcinoma: Evidence from a Large European Cohort of 95 Patients
Authors: C Ricci, A Righi, F Ambrosi, D Gibertoni, F Maletta, S Uccella, F Sessa, S Asioli, M Pellilli, R Maragliano, S La Rosa, MG Papotti, S Asioli
Journal: Endocrine Pathology (2019)
Effect of Interventions for Relapse or Progression Following Allogeneic Hematopoietic Cell Transplantation: A Single-Center Experience of 93 Patients.
Authors: Saiko Kurosawa, Takahiro Fukuda, Shin-ichiro Mori, Sung-Won Kim, Shigeo Fuji, Bungo Saito, Toshihiro Takahashi, Hiroki Yokoyama, Kinuko Tajima, Ryuji Tanosaki, Kensei Tobinai, Yoichi Takaue
Journal: Blood (2007)
Inclusion of HOXA Genes in Genetic and Biological Networks Defining Human Acute T-Cell Leukemia.
Authors: Jean Soulier, Emmanuelle Clappier, Jean-Michel Cayuela, Armelle Regnault, Marina Garcia-Peydro, Herve Dombret, Andre Baruchel, Maria-Luisa Toribio, Francois Sigaux
Journal: Blood (2004)
Climate emergency: healthcare systems aren’t prepared for risks to health, warns WHO
Authors: Aser García Rada
Journal: BMJ (2019)

Most countries’ healthcare systems are not sufficiently prepared for the increasing effects of climate change on human health, says a new report of the World Health Organisation.1

The report, released on 3 December during the UN Climate Change Conference (COP25) being hosted in Madrid to assess nations’ progress in dealing with climate change, drew on data from 101 countries surveyed by WHO.

Half (51) of the 101 countries surveyed have a national health and climate change strategy or plan. However, their content and scope vary widely, and most countries reported only moderate or low …
Endoscopic electrohydraulic lithotripsy of an enterolith causing afferent loop syndrome after Whipple’s operation
Authors: Jihye Lim, Hoonsub So, Sung W. Ko, Jun S. Hwang, Tae J. Song
Journal: Endoscopy (2019)

We present the case of a 77-year-old man with an enterolith and severe jejunal stricture causing afferent loop syndrome, who was successfully treated with endoscopic balloon dilation and subsequent electrohydraulic lithotripsy (EHL).
Mutations at Residues 315 and 317 in the ABL Kinase Domain Are the Main Cause of Resistance to Dasatinib in Philadelphia-Positive (Ph+) Leukemia Patients (pts).
Authors: Simona Soverini, Giovanni Martinelli, Sabrina Colarossi, Alessandra Gnani, Fausto Castagnetti, Gianantonio Rosti, Costanza Bosi, Stefania Paolini, Michela Rondoni, Pier Paolo Piccaluga, Francesca Palandri, Panagiota Giannoulia, Giulia Marzocchi, Simona Luatti, Elisabetta Abruzzese, Ilaria Iacobucci, Nicoletta Testoni, Michele Baccarani
Journal: Blood (2006)
Relapse Prevention After Recovery in Patients With Persistent Major Depressive Disorder—An Active Pursuit
Authors: Marlene P. Freeman
Journal: JAMA Psychiatry (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Membrane Type 1-Matrix Metalloproteinase Is Directly Involved in G-CSF Induced Human Hematopoietic Stem and Progenitor Cell Mobilization.
Authors: Abraham Avigdor, Shimon Schwartz, Polina Goichberg, Isabelle Petit, Izhar Hardan, Igor Resnick, Shimon Slavin, Arnon Nagler, Tsvee Lapidot
Journal: Blood (2004)
Elderly Patients with Acute Myeloid Leukemia Are Not All the Same: Results of the Prospective DSIL AML96 Trial.
Authors: Markus Andreas Schaich, Walter E. Aulitzky, Heinrich Bodenstein, Martin Bornhaeuser, Thomas Illmer, Ulrike Schaekel, Norbert Schmitz, Ulrich S. Schuler, Silke Soucek, Christian Thiede, Hannes Wandt, Gerhard Ehninger
Journal: Blood (2007)
Influence of Genetic Single Nucleotide Polymorphisms in CYP3A4, CYP3A5, GSTP1, GSTM1, GSTT1 and MDR1 Genes on Survival and Treatment Related Toxicity in Patients with Multiple Myeloma Treated in the HOVON 24 Trial.
Authors: Pieter Sonneveld, Celine Schilthuizen, Henk Lokhorst, Edo Vellenga, Reinier Raymakers, Yvonne de Knegt, Eric Kamst, Bronno van der Holt
Journal: Blood (2005)
Building on the Promise of Cancer Vaccines for Solid Tumors
Authors: Craig L. Slingluff
Journal: Clinical Cancer Research (2019)

A novel telomerase vaccine (INVAC-1) has been evaluated in a phase I clinical trial (n = 26). It induced CD8+ and CD4+ T-cell responses and reduced circulating regulatory T cells. The findings support further development, especially in combination with vaccine adjuvants, plus therapies to increase immune infiltrates into solid tumor metastases.See related article by Teixeira et al., p. 588.
The role of drug, dose, and the tolerance/intolerance of new drugs in multiple drug hypersensitivity syndrome
Authors: Lukas Jörg, Daniel Yerly, Arthur Helbling, Werner Pichler
Journal: Allergy (2019)

Abstract Background Multiple drug hypersensitivity syndrome (MDH) is used to describe persons with a drug hypersensitivity reaction (DHR) to at least two chemically unrelated drugs, confirmed by skin test or in vitro assay. Methods Medical records of 25 patients with MDH, tested and confirmed at our allergy division, were retrospectively evaluated in terms of clinical course, involved drugs, daily drug dose, latency periods, test results of skin test and cellular assays, and tolerated drugs in subsequent pharmacological treatments. Results Multiple drug hypersensitivity syndrome almost exclusively appeared as a delayed, often severe DHR and started in 14/25 with a drug reaction with eosinophilia and systemic symptoms (DRESS). Penicillins (13/25, 52.0%) and cephalosporins (6/25, 24.0%), typical high‐dose drugs, were most often identified as elicitors of MDH, especially at the first DHR, followed by aromatic antiepileptics (7/25, 28.0%), vancomycin (4/25, 16.0%), and antibiotic sulfonamides (4/25, 16.0%). Cephalosporins, clindamycin, and radio contrast media (RCM) were mainly involved in subsequent DHR. The median daily drug dose of all drug trigger was 1875.0 mg (662.5; 2100.0) at the first DHR and 600.0 mg (300.0; 1300.0) at subsequent DHR, P = .0420. Conclusion High‐dose drugs, especially beta‐lactam antibiotics, RCM and clindamycin, are common elicitors of subsequent DHR in patients with MDH. Macrolides, quinolones, doxycycline, nonaromatic antiepileptics, and paracetamol were often tolerated. As the same drugs elicited both flare‐up reactions and real DHR, drug‐induced flare‐up reactions may be precursors of a possible second DHR and MDH. The administration of highly dosed drugs should be avoided in patients at risk for MDH.
Clarithromycin-Resistant <i>H pylori</i> Faces New Foe
Authors: Rebecca Voelker
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TGFB1 Functional Polymorphisms: Impact on Outcome in Allogeneic Unrelated Donor Haematopoietic Stem Cell Transplantation
Authors: Mariano Berro, Louise Cooke, Neema P Mayor, Gustavo Kusminsky, Steven G.E. Marsh, J. Alejandro Madrigal, Bronwen E. Shaw
Journal: Blood (2008)
GHSR deficiency exacerbates cardiac fibrosis: role in macrophage inflammasome activation and myofibroblast differentiation
Authors: Mo Wang, Lei Qian, Jing Li, Hao Ming, Li Fang, Yingjia Li, Man Zhang, Yaohua Xu, Yiqian Ban, Weizhen Zhang, Youyi Zhang, Yahan Liu, Nanping Wang
Journal: Cardiovascular Research (2019)

Sustained activation of β-adrenergic signalling induces cardiac fibrosis, which marks progression to heart failure. GHSR (growth hormone secretagogue receptor) is the receptor for ghrelin, which is an orexigenic gastric hormone with newly defined cardiovascular effects. The present study determined the effects of GHSR deficiency in a mouse model of isoproterenol (ISO)-induced cardiac fibrosis and examined the underlying mechanism.Histochemical studies showed that GHSR deficiency exacerbated cardiac fibrosis. Quantitative RT-PCR, western blotting, and immunofluorescence staining demonstrated that cardiac fibroblasts isolated from GHSR-/- mice exhibited increased expression of marker genes for myofibroblast trans-differentiation (α-SMA, SM22, and calponin) upon transforming growth factor-β treatment compared to wild-type mice. RNA-sequencing of heart transcriptomes revealed that differentially expressed genes in GHSR-/- hearts were enriched in such biological processes as extracellular matrix organization, inflammatory response, lipid metabolism, cell cycle, migration, and adhesion. Particularly, GHSR deficiency increased Wnt/β-catenin pathway activation in ISO-induced myocardial fibrosis. In addition, loss of GHSR in macrophages instigated inflammasome activation with increased cleavage and release of interleukin-18.These results for the first time demonstrated that GHSR deficiency aggravated ISO-induced cardiac fibrosis, suggesting that GHSR was a potential target for the intervention of cardiac fibrosis.
Removal of a migrated lumen-apposing metal stent and endoscopic closure of a gastrocolonic fistula
Authors: Margaret G. Keane, Omar Barbouti, David Reffitt, Deepak Joshi, Stephen Gregory, Andreas Prachalias, John Devlin
Journal: Endoscopy (2019)

An 85-year-old woman presented with a 3-month history of weight loss and vomiting due to a large pancreatic fluid collection arising from the body of the pancreas. Diagnostic endoscopic ultrasound (EUS) confirmed the fluid was acellular with elevated amylase and low carcinoembryonic antigen, compatible with a pancreatic pseudocyst. As the patient remained symptomatic, EUS-guided cystgastrostomy with a 10-mm Hot AXIOS stent (Boston Scientific, Marlborough, Massachusetts, USA) was performed via the stomach using a standard approach [1] [2] [3], and 1 L of straw-colored fluid drained immediately into the stomach. Following cyst drainage, the patient improved clinically and was discharged home the next day.
All Trans Retinoic Acid (atRA) Differentiation Markers in Normal and Retinoid-Resistant Acute Promyelocytic Leukemia Cells Revealed Induction of atRA Metabolism as Relevant Prognostic of APL Sensitivity to Therapy.
Authors: Ronan Quere, Aurelie Baudet, Bruno Cassinat, Gerald Bertrand, David Piquemal, Laurent Manchon, Jacques Marti, Christine Chomienne, Therese Commes
Journal: Blood (2005)
The psychological impact of Stevens–Johnson syndrome and toxic epidermal necrolysis on patients’ lives: a Critically Appraised Topic*
Authors: P. O'Reilly, C. Kennedy, P. Meskell, A. Coffey, I. Delaunois, L. Dore, S. Howard, B. Ramsay, C. Scanlon, D.M. Wilson, B. Whelan, S. Ryan
Journal: British Journal of Dermatology (2019)

A 65-year-old man presented with a 12-h history of deteriorating rash. Two weeks previously he had completed a course of neoadjuvant chemotherapy for ductal carcinoma of the breast. On examination there were bullae, widespread atypical targetoid lesions and 15% epidermal detachment. There was no mucosal involvement on presentation, but subsequently it did evolve. Skin biopsy showed subepidermal blistering with epidermal necrosis. This confirmed our clinical diagnosis of overlap Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). On transfer to intensive care he was anxious and fearful.What are the psychological impacts of SJS/TEN on this man's life?SJS and TEN have devastating outcomes for those affected.To conduct a Critically Appraised Topic to (i) analyse existing research related to the psychological impact of SJS and TEN and (ii) apply the results to the clinical scenario.Seven electronic databases were searched for publications focusing on the psychological impact of SJS/TEN on adults over 18 years of age.Six studies met the inclusion criteria. Healthcare practitioners' (HCPs') lack of information around the disorder was highlighted. Patients experienced undue stress and fear. Some patients had symptoms aligned to post-traumatic stress disorder (PTSD), anxiety and depression.The evidence suggests that SJS and TEN impact psychologically on patients' lives. Education of HCPs, to address their lack of awareness and information on SJS/TEN, should facilitate their capacity to provide information and support to patients, thereby reducing patient anxiety. On discharge, a follow-up appointment with relevant HCPs to reduce the possibility of PTSD occurring should be considered.
The relationship between tumor markers and histopathologic and demographic features of patients with breast cancer and their distinctive role in metastatic process.
Authors: Kubra Aydin, Meliha Melin Uygur, Hatice Odabas, Taner Korkmaz, Nurgul Yasar, Nur Dinc, Dincer Aydin, Sinemis Yuksel, Ozlem Balvan, Aslihan Guven, Alparslan Mayadagi, Mehmet Aliustaoglu, Mahmut Gumus
Journal: Journal of Clinical Oncology (2013)

e11540 Background: Tumor marker monitoring is generally performed by the physicians, although in many guidelines, it has not been recommended for breast cancer. In this study, we aimed to research the role of CEA and CA15.3 levels in metastatic process. Methods: In between years 2000 January and 2011 August, the documents of 482 female patients followed by breast cancer diagnosis in Medical Oncology and Radiation Oncology clinics of Kartal Dr. Lutfu Kirdar Education and Research Hospital, were evaluated retrospectively. Results: To determine the role of CEA and CA15.3 levels in evaluation of metastatic process, ROC analysis was performed and its cut-off values were 1.3 ng/ml and 14 U/ml, respectively. Sensitivities of CA15.3 and CEA levels were detected as 83.33% and 87.50%; specificities were 40.80% and 41.14%, respectively. Evaluation of the relationship between CEA and CA15.3 levels and the status of hormone receptors by ROC analysis showed the cut-off values as 26 U/ml and 1,6 ng/ml, respectively. In determination of endocrine sensitivity, the sensitivities of tumor markers elevation were 88.17% and 54.12%, respectively. Their specificities were 26.92% and 73.08%. CEA level elevation in hormone sensitive patients was statistically significant (p: 0.007). When sensitivity and specificity of CA15.3 and CEA levels on detection of c-erbB2 positivity were evaluated by ROC analysis, cut-off values were determined as 17 U/ml and 1,7 ng/ml. Sensitivities of these distinctive cut-off values were found as 58.8% and 71.15% and specificities were 60% and 51.67% (p: 0.017). When the relation between CA15.3 and CEA levels and node involvement was evaluated by ROC analysis, cut-off values were respectively 16 U/ml and 0.9 ng/ml. Their sensitivities were 53.45% and 87.93% and specificities were 55.56% and 51.67%, respectively. Conclusions: The levels of tumor markers have been suggested to have a significant role in prognosis of the disease with respecttothe correlation between different histopathological and clinical features and tumor markers. Randomised controlled prospective studies planned and performed in this issue may clarify this uncertainity.
Results of a Phase I/II Study of Gemtuzumab Ozogamicin Added to Fludarabine (F), Melphalan (M) and Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) for Relapsed Myeloid Leukemias.
Authors: Marcos de Lima, S. Giralt, Z. Caldera, G. McCormick, M. Qazilbash, P. Anderlini, E. J. Shpall, C. Hosing, M. Donato, S. Kornblau, I. Khouri, T. Martin, D. Couriel, R. Champlin
Journal: Blood (2005)
临床试验中病人获益的评估——应该由医生还是由病人评估？这重要吗？
Authors: 张拓红
Journal: BMJ (2008)

医生需要从病人的角度理解新疗法的获益，因为他们必须判断向病人提供这些疗法的相对风险和获益。健康状况评价应满足这种需求。目前已开发出了数种有效、可靠、对治疗敏感的由病人完成的测评工具。这些工具为了解某种治疗对预后的影响提供了宝贵线索，例如对功能和生活质量等的影响。对病人而言，功能和生活质量可能比单纯生存更为重要。然而，对某些情况，目前尚无测量特定疾病健康状况的指标，此时则需进行临床变化的整体评估。