tbuckley/cabot-search huggingface dataset:
Therapeutic Approaches to Aging
Authors: Eoin D. O’Sullivan, Katie J. Mylonas, David A. Ferenbach
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fluid management in the critically ill
Authors: Jean-Louis Vincent
Journal: Kidney International (2019)

Fluid therapy, which is provided to restore and maintain tissue perfusion, is part of routine management for almost all critically ill patients. However, because either too much or too little fluid can have a negative impact on patient outcomes, fluid administration must be titrated carefully for each patient. The "salvage, optimization, stabilization, de-escalation" (SOSD) mnemonic should be used as a general guide to fluid resuscitation, and fluid administration should be adapted according to the course of the disease. In the initial salvage phase, lifesaving fluid should be administered generously. Once hemodynamic monitoring is available, fluid administration should be optimized by determining the patient's fluid status and the need for further fluid. This determination can be difficult, however; clinical indicators of hypovolemia, such as heart rate, blood pressure, and urine output, may not detect early hypovolemia, and edema is a late sign of fluid overload. Dynamic tests of fluid responsiveness such as pulse pressure or stroke volume variation can be used in only a small percentage of critically ill patients, and thus a fluid challenge technique is most frequently used to assess ongoing fluid requirements. Once a patient has been stabilized, efforts should start to concentrate on removing excess fluid. Which fluid should be used remains a matter of some debate. Crystalloid solutions are cheaper than colloid solutions, but colloid solutions remain in the intravascular space for a longer period, making edema less likely. Thus crystalloids and colloids should be used together, especially in patients likely to require large fluid volumes. Human albumin is a natural colloid and may have beneficial effects in patients with sepsis in addition to its volume effects. Fluids should be prescribed as are other medications, taking into account individual patient factors, disease processes, and other treatments.
PHENOTYPING PROGRESSION OF SECONDARY MITRAL REGURGITATION IN CHRONIC SYSTOLIC HEART FAILURE
Authors: Henrike Arfsten, Philipp Bartko, Noemi Pavo, Gregor Heitzinger, Julia Mascherbauer, Christian Hengstenberg, Martin Hülsmann, Georg Goliasch
Journal: Journal of the American College of Cardiology (2019)
Abstract 298: Irisin is an Endogenous Negative Regulator of Pathological Cardiac Hypertrophy
Authors: Yifan Zhao, Yawei Xu, Wenhui Peng
Journal: Circulation Research (2018)

Cardiac hypertrophy is a common pathophysiological process in various cardiovascular disease which still has no effective therapies. Irisin is a novel myokine mainly secreted by skeletal muscle which is involved in the regulation of energy metabolism. However, its role in cardiac hypertrophy is still unclear. In the present study, we found that serum irisin concentration is significantly elevated in patients with hypertension. Moreover, irisin concentration has strong correlation with left ventricular posterior wall thickness(LVPWT) and intraventricular septal thickness (IVST) which are two major parameters to measure left ventricular hypertrophy. The above results suggested that irisin may be involved in the regulation of pressure overload-induced cardiac hypertrophy. Hence, we further generated transverse aortic constriction-induced cardiac hypertrophy murine model. We found that irisin expression in heart and serum were both elevated in hypertrophic murine hearts. The in vitro study also indicated the angiotensin II treated cardiomyocytes have a higher level of irisin concentration. These data indicated that cardiomyocyte can secret irisin and the irisin concentration is elevated after hypertrophic stimuli. Furthermore, we demonstrated that cardiac hypertrophy was significantly attenuated with improved cardiac function assessed by echocardiography after irisin administration. HE and PSR staining also showed decreased cardiomyocytes size and fibrosis. Mechanistically, we demonstrated that cardiomyocytes treated with ADAM family inhibitor (TAP-2) has a lower irisin level while the expression of irisin precursor (FNDC5) has no obvious alteration. These data implied that FNDC5 was cleaved into irisin, at least partially, in a ADAM family dependent manner. Further we found that irisin administration activates AMPK and subsequently inhibited activation of mTOR. In conclusion, we demonstrated that cardiomyocytes secret irisin in a ADAM family dependent manner, administration of irisin attenuated pressure overload-induced cardiac hypertrophy and fibrosis, improved cardiac function by AMPK-mTOR signaling.
Sixty seconds on . . . vaping
Authors: Nigel Hawkes
Journal: BMJ (2019)

The trend is up but the numbers are still low. Public Health England (PHE) says in a new report that only 1.7% of under 18s use e-cigarettes weekly or more, most of whom also smoke.1 Among those who have never smoked, only one in 500 use e-cigarettes regularly.

It has, if you go back as far as 2014. Surveys by …
Dual Specificity Phosphatase 12 Regulates Hepatic Lipid Metabolism Through Inhibition of the Lipogenesis and Apoptosis Signal–Regulating Kinase 1 Pathways
Authors: Zhen Huang, Lei‐Ming Wu, Jie‐Lei Zhang, Abdelkarim Sabri, Shou‐Jun Wang, Gui‐Jun Qin, Chang‐Qing Guo, Hong‐Tao Wen, Bin‐Bin Du, Dian‐Hong Zhang, Ling‐Yao Kong, Xin‐Yu Tian, Rui Yao, Ya‐Peng Li, Cui Liang, Peng‐Cheng Li, Zheng Wang, Jin‐Yan Guo, Ling Li, Jian‐Zeng Dong, Yan‐Zhou Zhang
Journal: Hepatology (2019)

Nonalcoholic fatty liver disease (NAFLD) has become the most common cause of chronic liver disease worldwide. Due to the growing economic burden of NAFLD on public health, it has become an emergent target for clinical intervention. DUSP12 is a member of the dual specificity phosphatase (DUSP) family, which plays important roles in brown adipocyte differentiation, microbial infection, and cardiac hypertrophy. However, the role of DUSP12 in NAFLD has yet to be clarified. Here, we reveal that DUSP12 protects against hepatic steatosis and inflammation in L02 cells after palmitic acid/oleic acid treatment. We demonstrate that hepatocyte specific DUSP12-deficient mice exhibit high-fat diet (HFD)-induced and high-fat high-cholesterol diet-induced hyperinsulinemia and liver steatosis and decreased insulin sensitivity. Consistently, DUSP12 overexpression in hepatocyte could reduce HFD-induced hepatic steatosis, insulin resistance, and inflammation. At the molecular level, steatosis in the absence of DUSP12 was characterized by elevated apoptosis signal-regulating kinase 1 (ASK1), which mediates the mitogen-activated protein kinase (MAPK) pathway and hepatic metabolism. DUSP12 physically binds to ASK1, promotes its dephosphorylation, and inhibits its action on ASK1-related proteins, JUN N-terminal kinase, and p38 MAPK in order to inhibit lipogenesis under high-fat conditions. Conclusion: DUSP12 acts as a positive regulator in hepatic steatosis and offers potential therapeutic opportunities for NAFLD.
SERIAL CARDIOPULMONARY EXERCISE TESTING IN PATIENTS WITH REPAIRED EBSTEIN'S ANOMALY: IS EXERCISE CAPACITY IMPROVING AFTER SURGERY?
Authors: Maria Irene Barillas Lara, Yaoshan Dun, Sonia M. Fortin Gamero, Yazan Assaf, Amanda Bonikowske, Thomas Allison
Journal: Journal of the American College of Cardiology (2019)
LEARNING HOW TO SUCCESSFULLY ENROLL AND ENGAGE PEOPLE IN A MOBILE SYNC-FOR-SCIENCE PLATFORM TO INFORM SHARED DECISION-MAKING
Authors: Sanket Shishir Dhruva, Carlos Mena-Hurtado, Jeptha Curtis, Leslie Krumholz, Dave Hutten, Wade Schulz, John Rumsfeld, Frederick Masoudi, Kathleen Hewitt, Jennifer Bae, Allen Hsiao, Harlan M. Krumholz
Journal: Journal of the American College of Cardiology (2019)
EARLY AND LATE HEART FAILURE POST-LIVER TRANSPLANTATION, PREDICTORS, AND OUTCOMES
Authors: Mohammad Al-Ani, Sahil Prasada, Ahmed Ouni, Ameet Patel, Forat Lutfi, Angela Dolganiuc, Andreas Zori, Mustafa Ahmed, Juan Vilaro, Roberto Firpi
Journal: Journal of the American College of Cardiology (2019)
Biomarkers in community-acquired pneumonia: still searching for the one
Authors: Oriol Sibila, Marcos I. Restrepo
Journal: European Respiratory Journal (2019)

<b>Fibroblast growth factor 21 (FGF21) predicts severity of illness, clinical stability and mortality in community-acquired pneumonia. Validation is needed to confirm the application of FGF21 in clinical practice.</b>http://ow.ly/SYI730nuRc1
THE PROGNOSTIC IMPACT OF TRANSCATHETER AORTIC VALVE IMPLANTATION ON THE PULMONARY ARTERY SYSTOLIC PRESSURE
Authors: Abdalla Hassan, Ashraf Abugroun, Cecilia Wong, Anouch Matevossian, David Kearney, Gerard Aurigemma, Nikolaos Kakouros
Journal: Journal of the American College of Cardiology (2019)
HERE'S A CLOT, THERE'S A CLOT, EVERYWHERE A CLOT, CLOT: GIANT LEFT ATRIAL THROMBUS WITH ACUTE PULMONARY EMBOLISM AND LOWER EXTREMITY VENOUS THROMBUS - LATE ONSET ANTIPHOSPHOLIPID SYNDROME (APS)
Authors: Deepti Upparapalli, Jesus Vargas, Hafsa Tariq, Haitham Dib
Journal: Journal of the American College of Cardiology (2019)
RNA Editing of Tumor Suppressor Mir-26a Promotes Malignant Progenitor Propagation in Chronic Myeloid Leukemia
Authors: Raymond H Diep, Qingfei Jiang, Jane Isquith, Maria A. Zipeto, Jessica Pham, Nathan Delos Santos, Julisia Chau, Sheldon Morris, Catriona Jamieson
Journal: Blood (2018)
LACK OF OBSTRUCTIVE CORONARY ARTERY DISEASE ON INITIAL TESTING WITH CORONARY COMPUTED TOMOGRAPHY ANGIOGRAPHY IN SYMPTOMATIC PATIENTS LOWERS TOTAL AND DOWNSTREAM COSTS OVER A 5 YEAR PERIOD COMPARED TO NORMAL STRESS ECHOCARDIOGRAPHY
Authors: Cory G. Madigan, Laith Dinkha, Jessica Rouse, Chu C. Chu, Andrew C. Wyatt, Susan G. Williams, Mitchell H. Bowman, Brandon L. Walker, Dustin Thomas
Journal: Journal of the American College of Cardiology (2019)
Optimal sunscreen use prevents holiday erythema
Authors: J. Narbutt, P.A. Philipsen, G.I. Harrison, K.A. Morgan, K.P. Lawrence, K.A. Baczynska, K. Grys, M. Rogowski‐Tylman, I. Olejniczak‐Staruch, A. Tewari, M. Bell, C. O'Connor, H.C. Wulf, A. Lesiak, A.R. Young
Journal: British Journal of Dermatology (2019)

Rates of skin cancer are increasing more rapidly in the UK than any other form of cancer. The deadliest form of the disease is melanoma skin cancer, which affects 128% more people now than it did 28 years ago. Sun protection factors (SPFs) are known to protect the skin from sunburn when sunscreen is applied at 2 mg per cm‐2. However, whilst on holiday, people typically apply just 0.8 mg cm‐2 of sunscreen. This study aimed to identify if typical sunscreen application during a holiday with daily sun exposure results in skin cancer risk factors such as sunburn. Participants spent one week in Tenerife, a country with a very high ultraviolet index. 22 participants applied their own sunscreen without instruction and 40 participants were given SPF 15 sunscreen and guidance on effective application (three times daily at 2 mg cm‐2). It was found that participants who followed typical sunscreen application displayed significantly greater levels of sunburn and other risk factors associated with skin cancer compared to those who followed optimal application guidelines to achieve SPF 15. Individuals who followed the effective application guidelines with SPF 15 sunscreen had no sunburn on five exposed body sites. The results of this study highlight how typical sunscreen use is not providing sufficient protection from the sun in the majority of people. As well as this, it is demonstrated that sunburn is associated with an increased risk of developing skin cancer. Therefore, achieving an adequate SPF by teaching the general public how to properly apply sunscreen may be an important step in preventing skin cancer.
Sleep and Pathological Wakefulness at the Time of Liberation from Mechanical Ventilation (SLEEWE). A Prospective Multicenter Physiological Study
Authors: Martin Dres, Magdy Younes, Nuttapol Rittayamai, Tetyana Kendzerska, Irene Telias, Domenico Luca Grieco, Tai Pham, Detajin Junhasavasdikul, Edmond Chau, Sangeeta Mehta, M. Elizabeth Wilcox, Richard Leung, Xavier Drouot, Laurent Brochard
Journal: American Journal of Respiratory and Critical Care Medicine (2019)

Rationale: Abnormal patterns of sleep and wakefulness exist in mechanically ventilated patients. Objectives: In this study (SLEEWE [Effect of Sleep Disruption on the Outcome of Weaning from Mechanical Ventilation]), we aimed to investigate polysomnographic indexes as well as a continuous index for evaluating sleep depth, the odds ratio product (ORP), to determine whether abnormal sleep or wakefulness is associated with the outcome of spontaneous breathing trials (SBTs). Methods: Mechanically ventilated patients from three sites were enrolled if an SBT was planned the following day. EEG was recorded using a portable sleep diagnostic device 15 hours before the SBT. The ORP was calculated from the power of four EEG frequency bands relative to each other, ranging from full wakefulness (2.5) to deep sleep (0). The correlation between the right and left hemispheres' ORP (R/L ORP) was calculated. Measurements and Main Results: Among 44 patients enrolled, 37 had technically adequate signals: 11 (30%) passed the SBT and were extubated, 8 (21%) passed the SBT but were not deemed to be clinically ready for extubation, and 18 (49%) failed the SBT. Pathological wakefulness or atypical sleep were highly prevalent, but the distribution of classical sleep stages was similar between groups. The mean ORP and the proportion of time in which the ORP was >2.2 were higher in extubated patients compared with the other groups (P < 0.05). R/L ORP was significantly lower in patients who failed the SBT, and the area under the receiver operating characteristic curve of R/L ORP to predict failure was 0.91 (95% confidence interval, 0.75-0.98). Conclusions: Patients who pass an SBT and are extubated reach higher levels of wakefulness as indicated by the ORP, suggesting abnormal wakefulness in others. The hemispheric ORP correlation is much poorer in patients who fail an SBT.
Abstract 284: Loss of Cardiomyocyte General Control of Amino-Acid Synthesis 5-like 1 Expression Impairs Mitochondrial Function and Exacerbates Heart Failure Progression
Authors: Manling Zhang, Dharendra Thapa, Janet R Manning, Michael W Stoner, Danielle Guimaraes, Catherine Corey, Sruti Shiva, Claudette St. Croix, Ning Feng, Charles F McTiernan, Michael N Sack, Iain Scott
Journal: Circulation Research (2018)

Background: Energy starvation resulting from impaired mitochondrial function is one of the key mechanisms of heart failure development. Emerging evidence shows that lysine acetylation is one of the critical post-translational modifications that modulates mitochondrial bioenergetic output. We have identified General Control of Amino-Acid Synthesis 5-like 1 (GCN5L1) as a key acetyltransferase protein responsible for dynamic mitochondrial protein acetylation, and that this mechanism plays an essential role in regulating fatty acid oxidation. However, the role of GCN5L1 regulation on mitochondrial function in heart failure development is unknown. Methods and results: We examined GCN5L1 expression in cultured neonatal cardiac myocytes (RNCM) challenged with hypertrophy inducer phenylepherine (PE), and in failing hearts. We found that GCN5L1 mRNA and protein expression is markedly decreased in RNCM treated with PE, and in heart failure induced by mouse transaortic constriction (TAC). In addition, total mitochondrial protein acetylation in failing hearts was significantly decreased, corresponding to the decreased levels of GCN5L1. Next, we investigated the impact of decreased level of GCN5L1 on mitochondrial function and cardiac function in response to pathological stress. We found that GCN5L1 knockdown by shRNA in RNCM results in a decrease in basal oxygen consumption rate and ATP-linked respiration upon PE stimulation. More importantly, knocking down GCN5L1 in the presence of PE exacerbates the RNCM hypertrophic response assessed by increased cellular area and elevated ANP and BNP. Consistent with these in vitro studies, cardiac specific GCN5L1 knockout mice subjected to TAC display accelerated cardiac hypertrophy and heart failure, compared to WT littermates (fractional shortening 15.7% vs 26.4%, n=6-7 in each group, P &lt; 0.05). Conclusion: GCN5L1 plays a critical role in mitochondrial function and cardiac bioenergetics in response to stress. Impaired GCN5L1 function might be one of the key mechanisms of metabolic derangement in heart failure development, and could be a promising therapeutic target.
Abstract P3-09-01: MYC dysregulates mitotic spindle function in triple-negative breast cancer creating a dependency on TPX2
Authors: A Goga, J Rohrberg, A Corella, M Taileb, S Kilinc, M-L Jokisch, R Camarda, A Zhou, S Balakrishnan, AN Chang, H Klein-Connolly
Journal: Cancer Research (2019)

Abstract Tumors that overexpress the MYC oncogene, including most receptor triple-negative breast cancers, frequently demonstrate aneuploidy, numerical chromosome alterations associated with highly aggressive cancers. Aneuploidy is also associated with rapid tumor evolution and poor patient outcome. We identify that MYC overexpression induces reversible defects in microtubule nucleation and mitotic spindle assembly, in TNBCs and other epithelial cells, promoting chromosome segregation defects, micronuclei and chromosomal instability (CIN). High TPX2 expression is permissive for mitotic spindle assembly and chromosome segregation in cells with MYC overexpression; whereas TPX2 depletion blocks mitotic progression, induces cell death and prevents tumor growth. Attenuating MYC expression reverses mitotic defects, even in established breast tumor cell lines, implicating an ongoing role for high MYC in the persistence of CIN in cancers. Our studies implicate the MYC oncogene as a regulator of spindle assembly and identify a new MYC-TPX2 synthetic-lethal interaction in TNBC that could represent a future therapeutic strategy in MYC-overexpressing cancers. Moreover, our studies suggest that blocking MYC activity can attenuate the emergence of CIN and tumor evolution. Citation Format: Goga A, Rohrberg J, Corella A, Taileb M, Kilinc S, Jokisch M-L, Camarda R, Zhou A, Balakrishnan S, Chang AN, Klein-Connolly H. MYC dysregulates mitotic spindle function in triple-negative breast cancer creating a dependency on TPX2 [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr P3-09-01.
EFFECTIVENESS AND SAFETY OF NON-VITAMIN K ANTAGONIST ORAL ANTICOAGULANTS IN OBESE NONVALVULAR ATRIAL FIBRILLATION PATIENTS: A POOLED CLAIMS DATABASE ANALYSIS
Authors: Steven Deitelzweig, Allison Keshishian, Amiee Kang, Amol Dhamane, Xuemei Luo, Xiaoyan Li, Neeraja Balachander, Lisa Rosenblatt, Jack Mardekian, Xianying Pan, Manuela Di Fusco, Alessandra Bassalobre Garcia, Huseyin Yuce, Gregory Y.H. Lip
Journal: Journal of the American College of Cardiology (2019)
Abstract 362: Aortic Valve Hamartoma: A Rare Valvular Tumor Mimicking Infective Endocarditis
Authors: Nethuja Salagundla, Nooraldin Merza, Islam Asm, Alzeerah Masoud, Muath Alsharif
Journal: Circulation Research (2018)

A 46 YO female with PMH of DM2, HTN, Morbid obesity presented to hospital with chief complaint of chest pain, fever and SOB. She had recent hospitalization and was managed for abdominal wall abscess, MRSA bacteremia and diagnosed with infective endocarditis with aortic valve vegetation by TEE, and was discharged with antibiotics. With her current presentation: Temp was 100.8F, blood cultures grew Klebsiella Oxycota, and on TTE there was concern of increased size of aortic valve vegetation with super infection. Repeat TEE showed increase in size of vegetation. CT surgeon suggested AVR with mechanical valve. Biopsy results of the aortic valve came back as Lipomatous hamartoma. Patient recovered well post procedure and antibiotics were discontinued. Discussion: Prevalence of valvular hamartoma is as rare as 0.01 to 0.02% contributing to low diagnosis rates. If patient does not have symptoms of inflammation or infection and does not meet clinical diagnostic criteria, tumors should be included in the differential as medical management is not appropriate for hamartomas and other valvular tumors, which needs urgent surgery to prevent life threatening embolization. Cardiac valve lipomatous hamartomas are very rare lesions with preferential localization on the pericardium followed by endocardial surface. Most common histologic type of cardiac valve tumor is papillary fibroelastoma, myxoma, fibroma and hamartoma. Even if they are asymptomatic, surgical treatment should be considered to prevent embolization to brain and coronary circulation. To the best of our knowledge, we are reporting the second case of native aortic valve hamartoma so far.
A CARDIAC α-ACTIN (ACTC1) GENE MUTATION CAUSES ATRIAL-SEPTAL DEFECTS ASSOCIATED WITH DILATED CARDIOMYOPATHY
Authors: Derk Frank, Ashraf Y. Rangrez, Corinna Friedrich, Sven Dittmann, Birgit Stallmeyer, Pankaj Yadav, Alexander Bernt, Ellen Schulze-Bahr, Ankush Borlepawar, Wolfram-Hubertus Zimmermann, Stefan Peischard, Wolgang Linke, Guiscard Seebohm, Hideo A. Baba, Marcus Krüger, Andreas Unger, Philip Usinger, Norbert Frey, Eric Schulze-Bahr
Journal: Journal of the American College of Cardiology (2019)
SCREENING FABRY DISEASE IN NON-SELECTIVE MALE PATIENTS WITH LEFT VENTRICULAR HYPERTROPHY
Authors: Alex Pui-Wai Lee, Josie T.Y. Chow, Kevin K.H. Kam, Yiting Fan, David Chan, Bun Sheng, Paul Choi, Ka Tak Jeffrey Wong
Journal: Journal of the American College of Cardiology (2019)
RARE ASSOCIATION OF CHURG-STRAUSS SYNDROME WITH AORTITIS AND AORTIC REGURGITATION: UTILITY OF MULTI-MODALITY CARDIAC IMAGING
Authors: Mandira Patel, Prashant Patel, Hong Seok Lee, Sami Nazzal, Prabhdeep Sethi, Ramdas Pai
Journal: Journal of the American College of Cardiology (2019)
PROGNOSTIC SIGNIFICANCE OF CORONARY COMPUTED TOMOGRAPHY ANGIOGRAPHY IN PATIENTS WITH DIABETES MELLITUS: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Muhammad Shahzeb Khan, Noman Lateef, Tariq J. Siddiqi, Safi U. Khan, Nisar Asmi, Faisal Khosa, Naser Yamani, Farook Mookadam, Rami Doukky, John H. Stroger
Journal: Journal of the American College of Cardiology (2019)
UNSUPERVISED MACHINE LEARNING CLUSTERING FOR STRATIFICATION OF CARDIAC RISK IN PATIENTS WITH EXERCISE ECHOCARDIOGRAPHY NEGATIVE FOR ISCHEMIA
Authors: Alaa Mabrouk Salem Omar, Roberto Ramirez, Faris Haddadin, Basera Sabharwal, Mariam Khandaker, Yash Patel, Edgar Argulian
Journal: Journal of the American College of Cardiology (2019)