tbuckley/cabot-search huggingface dataset:
RSK2Ser227 Is a Therapeutic Target of Myeloma Cells Regardless of Upstream Signalings.
Authors: Yuji Shimura, Junya Kuroda, Hisao Nagoshi, Mio Yamamoto-Sugitani, Tsutomu Kobayashi, Miki Kiyota, Ryuko Nakayama, Shinsuke Mizutani, Yoshiaki Chinen, Natsumi Sakamoto, Yosuke Matsumoto, Shigeo Horiike, Masaki Ri, Yukimasa Shiotsu, Shinsuke Iida, Tomohiko Taki, Masafumi Taniwaki
Journal: Blood (2012)
Lower Incidence of Acute Gvhd Is Associated with the Rapid Recovery of CD4+CD25+CD45RA+ Regulatory T Cells in Patients Who Received Haploidentical Allografts from NIMA-Mismatched Donors: A Retrospective (development) and Prospective (validation) Cohort-Based Study
Authors: Yu Wang, Xiang-Yu Zhao, Lan-Ping Xu, Wei Han, Huan Chen, Feng-Rong Wang, Xiao-Dong Mo, Yuan-Yuan Zhang, Xiaosu Zhao, Yuan Kong, Kaiyan Liu, Xiao-Jun Huang, Ying-Jun Chang
Journal: Blood (2016)
Cytopenias in Large Granular Lymphocyte Leukemia Are Mediated by Pro-Fibrotic Mesenchymal Stem Cells in the Bone Marrow Niche with Functional Restoration by FGFb
Authors: Adam W Mailloux, Ling Zhang, Lili Yang, Cody Wei, Lubomir Sokol, Lynn Moscinski, John M. Bennett, Thomas P. Loughran, P.K. Epling-Burnette
Journal: Blood (2011)
Liquid biopsy for detection of actionable mutation in various cancer patients
Authors: Shunji Takahashi, Masumi Ohtaki, Junichi Tomomatsu, Makiko Ono, Mayu Yunokawa, Yoshinori Ito, Tomoko Shibayama, Kokoro Kobayashi, Naoki Sasahira, Masato Ozaka, Keisho Chin, Kensei Yamaguchi, Naoki Fukuda, Masatoshi Nishizawa, Yusuke Nakamura, Low Siew-Kee
Journal: Annals of Oncology (2019)
Twentieth Century Practice.
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Does HLA-C Matching Predict the Engrafting Unit in Double Umbilical Cord Blood Transplants?: A Single Institution Retrospective Analysis
Authors: Michael T Tees, Brian C Betts, Hugo F Fernandez, Ryan Hillgruber, Ernesto Ayala, Teresa Field, Mohamed A Kharfan-Dabaja, Frederick L Locke, Asmita Mishra, Taiga Nishihori, Jose L Ochoa-Bayona, Lia Perez, Joseph Pidala, Claudio Anasetti, Marcie L Riches
Journal: Blood (2014)
Multi-Tissue, Long-Term Engraftment and Expansion of BCR-ABL-transduced Human Lin-CD34+ Cord Blood Cells in a Large Animal Model.
Authors: Fanyi Zeng, Mei-Jue Chen, Zhi-Jian Gong, Don A. Baldwin, Hui Qian, Jing-Bin Yan, Juan Wang, Xin Chen, Yan Ping Xiao, Yves Chalandon, Zhao-Rei Ren, Allen C Eaves, Connie J. Eaves, Shu-Zhen Huang, Xiaoyan Jiang
Journal: Blood (2009)
Transcatheter Interventions for Mitral Regurgitation
Authors: Jeroen J. Bax, Philippe Debonnaire, Patrizio Lancellotti, Nina Ajmone Marsan, Laurens F. Tops, James K. Min, Niccolo Piazza, Jonathon Leipsic, Rebecca T. Hahn, Victoria Delgado
Journal: JACC. Cardiovascular imaging (2019)
Telomere Length Is Associated with Specific Mutations and Mutation Classes in Patients with Acute Myeloid Leukemia
Authors: Justin M. Watts, Bogdan Dumitriu, Patrick Hilden, Christina Chen, Franck Rapaport, Ashwin Kishtagari, Jihae Ahn, Sean M. Devlin, Raajit K. Rampal, Ross L. Levine, Neal S. Young, Martin S. Tallman
Journal: Blood (2014)
Molecular Analysis Of Circulating Tumor Cells Identifies Mutations That Are Distinct From Those Present In The Bone Marrow Of Patients With Multiple Myeloma
Authors: Yuji Mishima, Jens Lohr, Yu-Tzu Tai, Ludmila Flores, Yosra Aljawai, Jacob P. Laubach, Paul G. Richardson, Aldo M Roccaro, Kenneth C. Anderson, Nikhil C. Munshi, Irene M. Ghobrial
Journal: Blood (2013)
Preliminary Results of a Phase II Study of HCVIDDoxil Alternated with Methotrexate-Cytarabine in Patients with Newly Diagnosed T-Cell Lymphoma.
Authors: Barbara Pro, Luis Fayad, Jorge Romaguera, Michelle Fanale, Anas Younes, Fredrick B. Hagemeister, Felipe Samaniego, Peter McLaughlin, M.A. Rodriguez, Larry Kwak, Nam H. Dang
Journal: Blood (2007)
Leukemia Cells with a BCR-ABL1-Like signature and/or IKZF1 deletions, but Not High CRLF2 Expression, Are Predictive of an Unfavorable Prognosis in Childhood B Cell Precursor Acute Lymphoblastic Leukemia
Authors: Arian Van Der Veer, Esmee Waanders, Rob Pieters, Marieke E. Willemse, Simon Reijmersdaal, Lisa J Russell, Christine J Harrison, William E. Evans, Vincent H.J. van der Velden, Peter M. Hoogerbrugge, Frank N. van Leeuwen, G. Escherich, Martin Horstman, Leila mohammadi Khankahdani, Dimitris Rizopoulos, Hester A. de Groot-Kruseman, Edwin Sonneveld, Roland P. Kuiper, Monique L. Den Boer
Journal: Blood (2012)
For CML Patients in Chronic Phase Who Achieve a Cytogenetic Response to Imatinib the Finding of a BCR-ABL Mutation Predicts for Progression to Advanced Phase but It Has No Such Significance in Primary Resistance.
Authors: Hugues de Lavallade, Jamshid S. Khorashad, Dragana Milojkovic, Simon Wagner, Jaspal Kaeda, John M. Goldman, Jane F. Apperley, David Marin
Journal: Blood (2007)
Late Altered Organ Function in Long Term Survivors after Allogeneic HSCT: A Paired Comparison with Their Identical Sibling Donor
Authors: Alicia Rovo, Thomas Daikeler, Joerg Halter, Dominik Heim, Jan Dirk Studt, Michael Medinger, Caroline Arber, Martin Stern, Dimitrios Tsakiris, Alan Tyndall, Alois Gratwohl, Andre Tichelli
Journal: Blood (2008)
A Randomized Trial of Bone Marrow (BM) Versus Peripheral Blood (PB) Allogeneic Hemopoietic Stem Cell Transplants (HSCT) in Patients with Myeloproliferative Disorders.
Authors: Andrea Bacigalupo, Maria Teresa van Lint, Attilio Olivieri, Marco Casini, Emanuele Angelucci, Franco Narni, Carmine Selleri, Paolo Di Bartolomeo, Fabio Ciceri, Renato Fanin
Journal: Blood (2006)
Medical Costs Analysis for Antifungal Prophylaxis in Neutropenic Patients with Hematological Malignancies: A Systematic Review Analysis.
Authors: Takamichi Shintani, Osamu Imataki, Hiroaki Ohnishi, Akira Kitanaka, Yoshitsugu Kubota, Terukazu Tanaka, Toshihiko Ishida
Journal: Blood (2007)
Results of an Interim Safety Analysis of a Phase 2 Study of Daratumumab (Dara) Plus Cyclophosphamide, Bortezomib, and Dexamethasone (CyBorD) in Previously Untreated and Relapsed Patients (Pts) with Multiple Myeloma (MM)
Authors: Habte Yimer, Jason Melear, Edward Faber, William I. Bensinger, John M Burke, Sriya Gunawardena, Murphy Sean, Hollee Parros, Yana Lutska, Mohamed Darif, Anil Londhe, Ming Qi, Jon Ukropec, Thomas Lin, Robert M. Rifkin
Journal: Blood (2017)
Inhibition of Sphk1 Activity in Erythrocytes Ameliorating the Pathophysiology of Sickle Cell Disease
Authors: Yujin Zhang, Anren Song, Vladimir Berka, Harinder S. Juneja, Jun Zhang, Ah-lim Tsai, Modupe Idowu, Martin Safo, Qibo Zhang, Danny C Alexander, Rodney E. Kellems, Yang Xia
Journal: Blood (2012)
Multiple Myeloma In Complete Remission After Autologous Stem Cell Transplantation: Impact of Bone Marrow Plasma Cell Assessment by Conventional Morphology on Disease Progression
Authors: Carlos Fernández de Larrea, Natalia Tovar, María Rozman, Laura Rosiñol, Juan I. Aróstegui, María Teresa Cibeira, Montserrat Rovira, Jordi Yagüe, Joan Blade
Journal: Blood (2010)
Lung Resection for Invasive Pulmonary Aspergillosis in Neutropenic Patients with Hematologic Malignancies: Long Term Results in Thirty Two Cases.
Authors: Thomas Gastinne, Cyril Touzeau, Stéphane Vigouroux, Steven Le Gouill, Béatrice Mahé, Viviane Dubruille, Jacques Delaunay, Patrice Chevalier, Thierry Guillaume, Christine Sagan, Françoise Gay-Andrieu, Patrick Germaud, Philippe Despins, Philippe Moreau, Jean-Luc Harousseau
Journal: Blood (2006)
Genome-Wide Association Study of Overall and Progression-Free Survival after HLA-Matched Unrelated Donor Blood and Marrow Transplantation (DISCOVeRY-BMT study)
Authors: Theresa Hahn, Leah Preus, Philip L. McCarthy, Marcelo C. Pasquini, Kenan Onel, Xiaochun Zhu, Stephen R. Spellman, Christopher Haiman, Daniel O. Stram, Loreall Pooler, Xin Sheng, Qianqian Zhu, Li Yan, Qian Liu, Qiang Hu, Song Liu, Alyssa I. Clay, Sebastiano Battaglia, David Tritchler, Lara E. Sucheston-Campbell
Journal: Blood (2015)
Long Term Infectious Complications Following Reduced Intensity Conditioning (RIC) Allogeneic HLA-Identical Sibling Transplantation (allo-SCT).
Authors: Anne Etienne, Mohamad Mohty, Catherine Faucher, Sabine Furst, Jean El-Cheikh, Christine Zandotti, Pierre Berger, Norbert Vey, Anne-Marie Stoppa, Reda Bouabdallah, Patrice Viens, Jean-Albert Gastaut, Didier Blaise
Journal: Blood (2006)
Dasatinib Exerts Differential Effects on Normal and BCR-ABL Positive Hematopoietic Cells in a Transgenic Mouse Model of Chronic Phase-CML
Authors: Claudia Schubert, Nicolas Chatain, Till Braunschweig, Mirle Schemionek, Kristina Feldberg, Melanie Hoffmann, Tim H. Brümmendorf, Satu Mustjoki, Olli Dufva, Steffen Koschmieder
Journal: Blood (2016)
Real-Life Data and a Single Center Experience on the Efficacy and Toxicity Profile of Imatinib in the Treatment of Elderly Patients with Chronic Myeloid Leukemia
Authors: Ahmet Emre Eskazan, Mert Oztas, Fatih Bektas, Sevil Sadri, Dilek Keskin, Nurgul Ozgur Yurttas, Selin Berk, Isil Erdogan Ozunal, Ayse Salihoglu, M. Cem Ar, Seniz Ongoren, Zafer Baslar, Ugur Ozbek, Yildiz Aydin, Teoman Soysal
Journal: Blood (2016)
Inhibition of Telomerase with Imetelstat Is Detrimental to Leukemia Stem Cells in Acute Myeloid Leukemia (AML)
Authors: Claudia Bruedigam, Frederik Otzen Bagger, Florian H Heidel, Catherine Kuhn, Solene Guignes, Axia Song, Rebecca Austin, Therese Vu, Erwin M Lee, Andrew S. Moore, Richard B. Lock, Lars Bullinger, Geoff R Hill, Steven W Lane
Journal: Blood (2014)
von Willebrand Factor Protects Ca2+-Dependent Structure of the Factor VIII Light Chain.
Authors: Masahiro Takeyama, Midori Shima, Keiji Nogami, Masahiro Okuda, Yoshihiko Sakurai, Kohei Tatsumi, Tomohiro Takeda, Ichiro Tanaka, Akira Yoshioka
Journal: Blood (2005)
Using digital technology for home monitoring, adherence and self-management in cystic fibrosis: a state-of-the-art review
Authors: Rebecca Jane Calthorpe, Sherie Smith, Katie Gathercole, Alan Robert Smyth
Journal: Thorax (2019)

Digital healthcare is a rapidly growing healthcare sector. Its importance has been recognised at both national and international level, with the WHO recently publishing its first global strategy for digital health. The use of digital technology within cystic fibrosis (CF) has also increased. CF is a chronic, life-limiting condition, in which the treatment burden is high and treatment regimens are not static. Digital technologies present an opportunity to support the lives of people with CF. We included 59 articles and protocols in this state-of-the-art review, relating to 48 studies from 1999 until 2019. This provides a comprehensive overview of the expansion and evolution of the use of digital technology. Technology has been used with the aim of increasing accessibility to healthcare, earlier detection of pulmonary exacerbations and objective electronic adherence monitoring. It may also be used to promote adherence and self-management through education, treatment management Apps and social media.
Predictive Factors for Latency Period and a Prognostic Model for Survival in Patients with Therapy-Related AML.
Authors: Moshe Ornstein, Sudipto Mukherjee, Sanjay R. Mohan, Paul Elson, Ramon V. Tiu, Yogenthiran Saunthararajah, Leslie Farhat, Cassandra Kendeigh, Anjali Advani, Matt Kalaycio, Jaroslaw P. Maciejewski, Mikkael A. Sekeres
Journal: Blood (2012)
Impact of Minor Histocompatibility Antigens (mHAg) Mismatches On Gvhd Incidence in Non-Myeloablative or Reduced Intensity Allogeneic Stem Cell Transplantation.
Authors: Cristiana Carniti, Francesco Spina, Antonio Vendramin, Simona Di Terlizzi, Anna Raganato, Anisa Bermema, Paolo Corradini
Journal: Blood (2009)
Targeting of JAK/STAT Signaling to Reverse Stroma-Induced Cytoprotection Against BCL2 Antagonist Venetoclax in Acute Myeloid Leukemia
Authors: Riikka Karjalainen, Mihaela Popa, Minxia Liu, Mika Kontro, Mireia Mayoral Safont, Alun Parsons, Kimmo Porkka, Krister Wennerberg, Emmet McCormack, Bjørn T. Gjertsen, Caroline A Heckman
Journal: Blood (2016)
Dietary Habits Related to Food Packaging and Population Exposure to PFASs
Authors: Herbert P. Susmann, Laurel A. Schaider, Kathryn M. Rodgers, Ruthann A. Rudel
Journal: Environmental Health Perspectives (2019)

Per- and polyfluoroalkyl substances (PFASs) are common industrial and consumer product chemicals with widespread human exposures that have been linked to adverse health effects. PFASs are commonly detected in foods and food-contact materials (FCMs), including fast food packaging and microwave popcorn bags.Our goal was to investigate associations between serum PFASs and consumption of restaurant food and popcorn in a representative sample of Americans.We analyzed 2003-2014 serum PFAS and dietary recall data from the National Health and Nutrition Examination Survey (NHANES). We used multivariable linear regressions to investigate relationships between consumption of fast food, restaurant food, food eaten at home, and microwave popcorn and serum levels of perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluorohexanesulfonic acid (PFHxS), and perfluorooctanesulfonic acid (PFOS).Calories of food eaten at home in the past 24 h had significant inverse associations with serum levels of all five PFASs; these associations were stronger in women. Consumption of meals from fast food/pizza restaurants and other restaurants was generally associated with higher serum PFAS concentrations, based on 24-h and 7-d recall, with limited statistical significance. Consumption of popcorn was associated with significantly higher serum levels of PFOA, PFNA, PFDA, and PFOS, based on 24-h and 12-month recall, up to a 63% (95% CI: 34, 99) increase in PFDA among those who ate popcorn daily over the last 12 months.Associations between serum PFAS and popcorn consumption may be a consequence of PFAS migration from microwave popcorn bags. Inverse associations between serum PFAS and food eaten at home-primarily from grocery stores-is consistent with less contact between home-prepared food and FCMs, some of which contain PFASs. The potential for FCMs to contribute to PFAS exposure, coupled with concerns about toxicity and persistence, support the use of alternatives to PFASs in FCMs. https://doi.org/10.1289/EHP4092.
Safety and Activity of Brentuximab Vedotin (BV) Plus Ifosfamide, Carboplatin, and Etoposide (ICE) for Relapsed/Refractory (Rel/Ref) Classical Hodgkin Lymphoma (cHL): Initial Results of a Phase I/II Trial
Authors: Ryan D Cassaday, Jonathan Fromm, Andrew J. Cowan, Edward N. Libby, Mary Philip, Sanaz Behnia, Margaret Nartea, Oliver Press, Ajay K Gopal
Journal: Blood (2016)
Efficacy of nivolumab for advanced gastric cancer
Authors: Ichiro Moriyama, Koshi Kawakami, Fumiyoshi Ikejiri, Fumimasa Takahashi, Shinichiro Matsuda, Norimi Ugata, Yasumasa Shimasaki, Yusuke Fujii, Kousuke Tsukano, Satoshi Yamanouchi, Ryusaku Kusunoki, Youichi Miyaoka, Ayana Nagamine, Michina Morioka, Noriyuki Hirahara, Ritsuro Suzuki, Hirofumi Fujishiro, Atsuo Tokuka, Akiyoshi Kanazawa, Yoshitsugu Tajima, Junji Suzumiya
Journal: Annals of Oncology (2019)
In Vitro and In Vivo Anti-Lymphoma Activity of the Anti-HLA-DR Monoclonal Antibody 1D09C3.
Authors: Carmelo Carlo-Stella, Massimo Di Nicola, Caterina Turco, Loredana Cleris, Cristiana Lavazza, Marco Milanesi, Paolo Longoni, Elisabetta Zorzan, Michele Magni, Massimo Ammirante, Arturo Leone, Franca Formelli, Alessandro M. Gianni
Journal: Blood (2004)
Using Neuro-oncology to teach GCSE students STEM-subjects
Authors: Lillie Shahabi, Golnaz Shahabi, Emma Wilcox, Catarina Campos, Zahra Shah, Daisy Holgate, Lilly Furssedonn, Dhuha Al-Tai, Saavun Jando, Aaron Ranny, Nirvan Nagra, Eesha Seksaria, Diogo Ferreira, Seema Dadhania, Shivani Soni, James Wang, Sophie Camp, Nelofer Syed, Matt Williams
Journal: Neuro-Oncology (2019)

Abstract Background The profile of brain tumours in the wider community has recently been raised. In this project we explored whether we could link brain tumour awareness with STEM education for secondary school pupils. We aimed to inspire the next generation by bringing research into formal and informal learning contexts. Method We worked with a local school to co-design and co-create a set of blended learning sessions. Each session consisted of some “biological” teaching and a practical activity. These included using IDH, MGMT and 1p/19q as models of varying genetic disorder and a Jenga-based game to teach radiobiology. Sessions were delivered every 1–2 weeks using a multidisciplinary team. We assessed impact through informal weekly feedback, a structured feedback form and linkage to GCSE curriculum items. We assessed costs using a staff-free FEC model. Results We delivered a total of 12 hours over 10 sessions. Feedback was overwhelmingly positive from the students – “The project has been very enlightening and rewarding”. We were able to link 60% of taught material to GCSE curriculum items. We estimated costs (materials) at £260. Students presented their work at the Imperial Science Festival and an additional conference. Discussion We have co-developed and piloted an innovative multi-disciplinary toolkit to use neuro-oncology as a way of teaching STEM subjects, though a pupil-centred approach. We are now seeking to pilot the materials with other neuroscience centres/ universities to support secondary schools and neuroscience centres/ universities in working collectively to create structured, strategic, and sustainable mechanisms for engagement.
Alternative Splice Variants of IRAK4 That Activate Innate Immune Signaling Are Associated with U2AF1 Mutations in Myelodysplastic Syndrome and Acute Myeloid Leukemia
Authors: Molly A Smith, Kwangmin Choi, Nathan Salomonis, Matthew J. Walter, Kakajan Komurov, Daniel T Starczynowski
Journal: Blood (2016)
A Phase II Clinical Trial of Azacitidine and Vorinostat for Patients with Acute Myeloid Leukemia (AML) or Myelodysplastic Syndromes (MDS) with Poor Performance Status, Comorbidities, Other Active Malignancies or Organ Dysfunction Not Eligible for Conventional Clinical Trials
Authors: Guillermo Montalban-Bravo, Xuelin Huang, Elias J. Jabbour, Gautam Borthakur, Courtney D. DiNardo, Naveen Pemmaraju, Jorge E. Cortes, Srdan Verstovsek, Tapan M. Kadia, Naval G. Daver, William G. Wierda, Yesid Alvarado, Marina Konopleva, Farhad Ravandi, Zeev Estrov, Nitin Jain, Ana Alfonso Pierola, Mark Brandt, Troy Sneed, Hsiang-Chun Chen, Hui Yang, Carlos E Bueso-Ramos, Sherry Pierce, Elihu H. Estey, Zachary S. Bohannan, Hagop M. Kantarjian, Guillermo Garcia-Manero
Journal: Blood (2016)
A Phase I Trial of Ibrutinib Plus Palbociclib in Patients with Previously Treated Mantle Cell Lymphoma
Authors: Peter Martin, Kristie Blum, Nancy L. Bartlett, Steven I. Park, Kami J. Maddocks, Jia Ruan, Maurizio Di Liberto, Xiangao Huang, Giorgio Inghirami, Pamela Harris, Selina Chen-Kiang, John P. Leonard
Journal: Blood (2016)
Chemokine receptor CXCR4: What is its role in gastrointestinal cancer?
Authors: Lucia Lombardi
Journal: Journal of Clinical Oncology (2013)

e14687 Background: Multiple metastasis is the predominant cause of colorectal cancer (CC) and pancreatic cancer (PC) related mortality. Chemokines receptors have been implicated in cancer metastatic process by directing the migration of tumour cells to sites of metastasis. However, their clinical relevance in gastrointestinal cancer has not been defined. The aim of our study was to evaluate the possible role of CXCR4 as prognostic factor in CC and PC. Methods: Quantitative determination of CXCR4 in serum samples were collected before and after surgery from 36 CC and 23 PC patients later treated with adjuvant (Ad) therapy or for metastatic (Meta) disease (19 Ad-and 17 Meta-CC; 15Ad-PC and 8 Meta-PC) and from 31 healthy controls (HC) enrolled as controls group, was performed by means of ELISA. Relative expression levels of CXCR4 in matched-pairs of tumour and adjacent normal tissue samples collected from the same 36 CC and 15 Ad-PC patients, were determined by means of qRT-PCR using the QuantiFast SYBR Green PCR kit. Results: Compared to HC, pre-operative CXCR4 serum levels were increased in both CC and PC patients. Post-operative serum levels were higher than those observed pre-operatively in 42% and 47% of patients with Ad- and Meta-CC, respectively. Conversely, in 53% and 50% of patients with Ad- and Meta-PC, CXCR4 serum levels decreased after surgical treatment. Furthermore, higher levels of CXCR4 were associated with advanced stages and in PC with lymph nodes involvement. In addition, CXCR4 was over-expressed in tumor compared to normal tissue in 42% and 41% of patients with Ad- and Meta-CC, and in 73% of patients with Ad-PC. In relation to clinical phenotype, all these patients had stage T3N1 disease in both disease. Conclusions: Our data showed that CXCR4 levels may be associated with tumor stage and disease progression in CC and PC patients. Further studies with larger samples size, might confirm the role for CXCR4 as prognostic factor and/or marker of patients’ response to therapy.
Analysis of Glucose Profiles in Imatinib-Resistant or Intolerant Chronic Myelogenous Leukemia (CML) Patients (pts) Treated with Nilotinib: Lack of Correlation between Glucose Levels and Nilotinib Efficacy.
Authors: Philipp le Coutre, Francis J. Giles, Andreas Hochhaus, Giovanni Martinelli, Jim Wang, Vanessa Passos, Marcia Kayath, Michele Baccarani, Hagop M. Kantarjian
Journal: Blood (2007)
Lenalidomide and Bortezomib: Targeting Osteoclastogenesis, Osteoclast Survival Factors, and Bone Remodeling Markers in Multiple Myeloma.
Authors: Iris Breitkreutz, Marc S. Raab, Sonia Vallet, Teru Hideshima, Noopur Raje, Constantine Mitsiades, Dharminder Chauhan, Nikhil C. Munshi, Paul G. Richardson, Kenneth C. Anderson
Journal: Blood (2007)
Ex Vivo Activity Profile of the CD123xCD3 Duobody® Antibody JNJ-63709178 Against Primary Acute Myeloid Leukemia Bone Marrow Samples
Authors: Ann Forslund, Khaja Syed, Amy Axel, Ronan McDaid, Yingzhe Li, Juan Ballesteros, Francois Gaudet, Ricardo M. Attar, Mark Salvati, Fei Huang, Kate Sasser
Journal: Blood (2016)
Predictive Value for Event-Free Survival of Interim 18F-FDG-PET In Patients with Diffuse Large B-Cell Lymphoma (DLBCL) Treated with 6 Cycles of Dose-Dense R-CHOP-14 Immunochemotherapy Plus Pegfilgrastim as First-Line Treatment: An Open-Label Clinical Trial In Spain.
Authors: Eva González-Barca, Miguel Canales, María Jesús Vidal, Albert Oriol, Antonio Salar, Joan Bargay, Montse Cortés, Juan Coya, José Francisco Tomás, Andrés López, José Javier Sánchez, Eva Donato, Andrés Llorente, Secundino Ferrer, Dolores Caballero
Journal: Blood (2010)
A Series of Human Cell-Based Artificial APC Expands Long-Lived, Th1-Biased, Viral Antigen-Specific CD4+ T Cells with a Central/Effector Memory Phenotpype Restricted by Common HLA-DR Alleles
Authors: Marcus O. Butler, Sascha Ansén, Makito Tanaka, Osamu Imataki, Alla Berezovskaya, Mary M. Mooney, Genita Metzler, Matthew I. Milstein, Lee M. Nadler, Naoto Hirano
Journal: Blood (2010)