tbuckley/cabot-search huggingface dataset:
Favorable Outcome in CLL Patients Not Treated Despite Presenting Iwcll Criteria: A Retrospective Analysis of the Brazilian CLL Group
Authors: Fernanda de Morais Marques, Verena Pfister, Flavia Parra, Mihoko Yamamoto, Rodrigo Santucci Silva, Marcelo Bellesso, Vinicius Campos de Molla, Ana Rita Da Fonseca, Yana Novis, Sérgio Costa Fortier, Talita Silveira, Guilherme Brasil Duffles Amarante, Valeria Buccheri, Matheus Vescovi, Carlos Sérgio Chiattone, Celso Arrais
Journal: Blood (2020)
Adriamycin/Nucleophosmin Binding Protein-Conjugated Nanoparticle (ADR-PMs-NPMBP) Enhances Anti-Leukemia Activities of Adriamycin in Acute Lymphoblastic Leukemia Cells
Authors: Yingyu Chen, Donghui Gan, Liping Luo, Zhengjun Wu, Yuwen Chen, Haijun Chen, Jianda Hu
Journal: Blood (2020)
Abstract 477: Modeling the Effect of <i>TBX5</i> Downregulation on Human Atrial Conduction Using Induced Pluripotent Stem Cell-derived Cardiomyocytes
Authors: Sherri M Biendarra-tiegs, Sergey Yechikov, Laura Houshmand, R. E Gonzalez, Zhi Hong Lu, David T Curiel, Stacey L Rentschler, Steven C George
Journal: Circulation Research (2020)

Atrial fibrillation (AF) poses a notable healthcare burden due to a high incidence in the increasing population over age 65 and limitations of current treatment approaches. One challenge to effectively treat AF is patient-to-patient heterogeneity in the underlying mechanisms of disease. Therefore, a better understanding of AF pathogenesis and more personalized approaches to therapy could reduce risk of side effects and improve therapeutic efficacy. Genome wide association studies (GWAS) have revealed several candidate genes for AF including TBX5 , which encodes for a transcription factor involved in heart development. While work in animal models suggests that loss of TBX5 promotes atrial arrythmias, experimental evidence in human cells is lacking. We created an in vitro model of human atrial conduction using day 60+ induced pluripotent stem cell-derived atrial-like cardiomyocytes (iPSC-aCMs) differentiated from three established healthy iPSC lines. Over 90% atrial-like purity (out of 350+ alpha-actinin positive cardiomyocytes) could be achieved based on MLC2v-/MLC2a+ immunofluorescent staining. TBX5 knockdown via esiRNA resulted in downregulation of genes related to conduction velocity ( GJA5 and SCN5A ), consistent with an enhanced risk of AF. Single cell optical electrophysiology demonstrated slightly reduced action potential amplitude and upstroke velocity for TBX5 knockdown cells versus GFP esiRNA controls, suggesting a functional effect of SCN5A downregulation. Additionally, microelectrode array studies have revealed a trend towards slowed conduction velocity with TBX5 knockdown compared to GFP esiRNA controls (13.1±3.0 cm/s vs 17.0±3.8 cm/s respectively). By further investigating the functional effects of modulating transcription factors such as TBX5 in iPSC-aCMs, our results provide enhanced insight into the regulation of atrial conduction and identify potential AF-related pathways for therapeutic targeting.
Population-Based Prevalence of Gastrointestinal Abnormalities at Colon Capsule Endoscopy
Authors: Fanny E.R. Vuik, Stella A.V. Nieuwenburg, Sarah Moen, Eline H. Schreuders, Marinka D. Oudkerk Pool, Elisabeth F.P. Peterse, Cristiano Spada, Owen Epstein, Ignacio Fernández-Urién, Albert Hofman, Ernst J. Kuipers, Manon C.W. Spaander
Journal: Clinical Gastroenterology and Hepatology (2020)
Clinical Characteristics and Outcome of Diffuse Large B Cell Lymphoma Among HTLV-1 Carriers in Peru: A Matched Cohort Study
Authors: Bryan Valcarcel, Daniel J Enriquez, Gustavo Sandival-Ampuero, Ursula Aviles-Perez, Juan C Haro, Cindy Alcarraz, Shirley Quintana, Marco Villena, Daniela Dueñas, Sandro Casavilca, Carlos Barrionuevo, Cesar Samanez-Figari, Luis E Malpica Castillo
Journal: Blood (2020)
A Multicenter, Retrospective Study of Accelerated Venetoclax Ramp-up in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia
Authors: Matthew S. Davids, Mazyar Shadman, Sameer A. Parikh, Chaitra S. Ujjani, Chinheng Chen, Cameron Walsh Johnson, Dingfeng Jiang, Cynthia Llamas, Dai Feng, Zaeem Khan, Nicole Lamanna
Journal: Blood (2020)
“Skull on Fire”
Authors: Stefan Govers, Friso M. van der Zant, Maurits Wondergem, Wouter A.M. Broos, Remco J.J. Knol
Journal: Clinical Nuclear Medicine (2020)

Abstract An 81-year-old woman was evaluated for a stroke. CT showed no intracranial abnormalities but diffuse patchy aspect of the neurocranium. An MRI and 18 F-NA PET/CT were performed to differentiate between metastases, Paget disease, hyperostosis frontalis interna, and primary malignancy. MRI yielded no additional findings. 18 F-NA PET/CT showed diffusely increased uptake in the skull and 4 spots with intense uptake. No other suspicious skeletal foci were seen elsewhere. Low-dose CT showed no sign of malignancy elsewhere. Image findings together with elevated serum alkaline phosphatase levels, slightly increased calcium levels, and normal phosphorus levels were interpreted as pathognomic for monostotic Paget.
Clinical Outcomes with Hypomethylating Agents in Patients with Myelodysplastic Syndrome/Myeloproliferative Neoplasm with Ring Sideroblasts and Thrombocytosis (MDS/MPN-RS-T); A Case Series
Authors: Maria Tariq Siddiqui, Rashmi Kanagal-Shamanna, Kiran Naqvi, Koji Sasaki, Lucia Masarova, Elias Jabbour, Naveen Pemmaraju, Tapan M. Kadia, Farhad Ravandi, Naval Daver, Gautam Borthakur, Sherry A. Pierce, Srdan Verstovsek, Prithviraj Bose, Hagop M. Kantarjian, Guillermo Garcia-Manero, Guillermo Montalban-Bravo
Journal: Blood (2020)
Comparison of Clinical and Laboratory Features, Drug Availability, and Outcomes of CLL Patients Treated in Public or in Private Hospitals in Brazil: A Retrospective Analysis of the Brazilian Registry of CLL
Authors: Verena Pfister, Fernanda de Morais Marques, Flavia Parra, Mihoko Yamamoto, Rodrigo Santucci Silva, Marcelo Bellesso, Wellington F Silva, Valeria Buccheri, Alita Azevedo, Yana Novis, Sérgio Costa Fortier, Talita Silveira, Laura Maria Fogliatto, Leila Martins Perobelli, Glaciano Ribeiro, Germison Silva Lopes, Vera Lucia de Piratininga Figueiredo, Matheus Vescovi, Carlos Sérgio Chiattone, Celso Arrais
Journal: Blood (2020)
Clinical Features and Outcome of HTLV-1 Carriers Diagnosed with Hodgkin Lymphoma in Peru: A Matched Cohort Study
Authors: Gustavo Sandival-Ampuero, Ursula Aviles-Perez, Bryan Valcarcel, Juan C Haro, Daniela Dueñas, Carlos Barrionuevo, Cindy Alcarraz, Sandro Casavilca, Marco Villena, Shirley Quintana, Cesar Samanez-Figari, Luis E Malpica Castillo, Daniel J Enriquez
Journal: Blood (2020)
Total Body Irradiation Among Recipients of Tcrαβ /CD19- Depleted Grafts in a Cohort of Children with Hematologic Malignances: Single Center Experience
Authors: Daria Kobyzeva, Larisa Shelikhova, Zhanna Shekhovtsova, Rimma Khismatullina, Maria Ilushina, Anna Loginova, Alexey Nechesnuyk, Michael Maschan
Journal: Blood (2020)
Aberrant Cell Cycle Programming Confers Rapid Lethality in the EuSOX11+ CCND1 MCL Mouse Model
Authors: Donna R Edwards, Pei-yu Kuo, Alessandro Lagana, Seongjee Park, Pavithra Nedumaran, Violetta Leshchenko, Stephanie Christie, Shashidhar Jatiani, Julie Teruya-Feldstein, Samir Parekh
Journal: Blood (2020)
Low Cholesterol, Low-Density Lipoprotein (LDL) and Triglycerides Plasma Levels Are Associated with Lower Risk of Arterial Occlusive Events in Chronic Myeloid Leukemia Patients Treated with Nilotinib
Authors: Giovanni Caocci, Olga Mulas, Isabella Capodanno, Mario Annunziata, Elisabetta Abruzzese, Sara Galimberti, Mario Tiribelli, Luigiana Luciano, Bruno Martino, Fausto Castagnetti, Gianni Binotto, Patrizia Pregno, Fabio Stagno, Monica Bocchia, Francesco Albano, Debora Luzi, Claudio Fozza, Massimiliano Bonifacio, Chiara Elena, Antonella Gozzini, Maria Pina Simula, Malgorzata Monika Trawinska, Claudia Baratè, Rossella Stella, Fiorenza De Gregorio, Gabriele Gugliotta, Francesca Pirillo, Daniele Cattaneo, Anna Sicuranza, Imma Attolico, Luigi Scaffidi, Emilia Scalzulli, Alessandra Iurlo, Robin Foà, Massimo Breccia, Giorgio La Nasa
Journal: Blood (2020)
Encouraging Results of Haploidentical Transplantation in Older Patents Using the Two-Step T Cell Tolerization Platform - Results of a Prospective Trial
Authors: Dolores Grosso, Matthew Carabasi, Joanne Filicko-O'Hara, John L. Wagner, William O'Hara, Shaik Rashid, Gina Mateja, Usama Gergis, Neal Flomenberg
Journal: Blood (2020)
Role of Age, Fitness and Concomitant Medications in CLL Patients Treated with Venetoclax
Authors: Anna Maria Frustaci, Annalisa Biagi, Annalisa Chiarenza, Marta Coscia, Stefania Ciolli, Luca Laurenti, Paolo Sportoletti, Gianluigi Reda, Marzia Varettoni, Francesca Romana Mauro, Roberta Murru, Claudia Baratè, Antonino Greco, Chiara Borella, Giulia Zamprogna, Enrica Antonia Martino, Candida Vitale, Francesca Morelli, Alberto Fresa, Valerio Guarente, Alessandro Noto, Massimiliano Postorino, Roberto Cairoli, Marco Montillo, Giovanni Del Poeta, Alessandra Tedeschi
Journal: Blood (2020)
Abstract IA07: UVB-induced tumor heterogeneity directs immune response in melanoma
Authors: Osnat Bartok, Sushant Patkar, Sapir Cohen, Kevin Litchfield, Hiren Karathia, Joo Sang Lee, Alejandro Jiménez-Sánchez, Chi-Ping Day, Lea Eisenbach, Martin Miller, Glenn Merlino, Eli Pikarsky, Arie Admon, Charles Swanton, Eytan Ruppin, Yardena Samuels, Yochai Wolf
Journal: Cancer Research (2020)

Abstract Little is known regarding the relationship between intra-tumor heterogeneity (ITH) and immune response in melanoma. Here, we explored the role of ITH in tumor rejection by establishing a melanoma mouse model and inducing UVB-derived mutations that increase both ITH and mutational load. This induction gives rise to highly aggressive tumors and decreased cytotoxic activity of tumor infiltrating lymphocytes (TILs). Conversely, single cell-derived melanoma clones with reduced ITH are swiftly rejected. Tumor rejection is accompanied by increased TIL reactivity and increased infiltration into the tumor core. Using phylogenetic tree analyses and mixing experiments of 20 single cell clones that lie along the phylogenetic tee we show that tumor rejection is strongly affected by number of injected clones and genetic diversity. We have, thus set up a novel, highly controlled system that enables us to study the interphase between the immune system and different layers of intra-tumor heterogeneity. Finally, the analysis of melanoma patient data identifies parallel observations, supporting the importance of ITH in determining patient survival and response to checkpoint blockade. Citation Format: Osnat Bartok, Sushant Patkar, Sapir Cohen, Kevin Litchfield, Hiren Karathia, Joo Sang Lee, Alejandro Jiménez-Sánchez, Chi-Ping Day, Lea Eisenbach, Martin Miller, Glenn Merlino, Eli Pikarsky, Arie Admon, Charles Swanton, Eytan Ruppin, Yardena Samuels, Yochai Wolf. UVB-induced tumor heterogeneity directs immune response in melanoma [abstract]. In: Proceedings of the AACR Virtual Special Conference on Tumor Heterogeneity: From Single Cells to Clinical Impact; 2020 Sep 17-18. Philadelphia (PA): AACR; Cancer Res 2020;80(21 Suppl):Abstract nr IA07.
<i>POU2AF1</i> As a Master Regulator of Oncogenic Transcription Factor Networks in Myeloma
Authors: Ricardo De Matos Simoes, Ryosuke Shirasaki, Huihui Tang, Shizuka Yamano, Benjamin G Barwick, Sara Gandolfi, Eugen Dhimolea, Sondra L. Downey-Kopyscinski, Olga Dashevsky, Brian Glassner, Michal Sheffer, Dhvanir Kansara, Megan Bariteau, Jeffrey Sorrell, Vikas Gupta, Aedin Culhane, Aviad Tsherniak, Francisca Vazquez, Larry H. Boise, Jonathan D. Licht, Constantine S. Mitsiades
Journal: Blood (2020)
Prognostic Importance of Measurable Residual Disease (MRD) Kinetics and Progression-Free Survival (PFS) Benefit in MRD+ Patients (Pts) with Ixazomib Vs Placebo As Post-Induction Maintenance Therapy: Results from the Multicenter, Double-Blind, Phase 3 TOURMALINE-MM4 Trial in Non-Transplant Newly Diagnosed Multiple Myeloma (NDMM) Pts
Authors: Bruno Paiva, Irene Manrique, Nicola Giuliani, Michele Cavo, Christine Rojas, Weijun Fu, María-Victoria Mateos, Meletios A Dimopoulos, Alexander Vorog, Cong Li, Bingxia Wang, Richard J Labotka, Ajeeta B Dash
Journal: Blood (2020)
Human Cytomegalovirus Selectively Suppresses the Megakaryo/Thrombopoiesis of PDGFR+ and αvβ3+ Megakaryocytes Via the TPO/c-Mpl Pathway after Allo-HSCT
Authors: Feng-qi Liu, Fei-er Feng, Gao-chao Zhang, Yan Su, Xue-yan Sun, Qiu-sha Huang, Qi Chen, Xiao Liu, Yun He, Xiao-lu Zhu, Hai-xia Fu, Kai-yan Liu, Xiao-hui Zhang
Journal: Blood (2020)
Outcomes of <i>De Novo</i> Acute Myeloid Leukemia with Monocytic Differentiation (FAB M4/5) Treated with Venetoclax and Decitabine
Authors: Abhishek Maiti, Sergej Konoplev, Courtney D. DiNardo, Tapan M. Kadia, Farhad Ravandi, Naval Daver, Naveen Pemmaraju, Gautam Borthakur, Prithviraj Bose, Ghayas C. Issa, Nicholas J. Short, Musa Yilmaz, Yesid Alvarado, Alessandra Ferrajoli, Elias Jabbour, Nitin Jain, Maro Ohanian, Koichi Takahashi, Philip A. Thompson, Caitlin R. Rausch, Kathryn Montalbano, Sherry A. Pierce, Keyur P. Patel, Guillermo Garcia-Manero, Hagop M. Kantarjian, Marina Konopleva
Journal: Blood (2020)
Abstract 452: Role of CD38 in Cardiovascular Performance and Its Use as a Therapeutic Target in Obesity-Induced Diastolic Dysfunction
Authors: Guillermo Agorrody, Thais Peclat, Lilian S Gomez, Sonu Kashyap, Carlos Escande, Paola Contreras, Eduardo N Chini
Journal: Circulation Research (2020)

Background: Cardiac tissue possesses high energetic requirements. During development of heart failure there is a shift from fatty acid oxidation to the utilization of other substrates. This transition leads to the decline in NAD/NADH ratio, which increases susceptibility to stress. CD38 is the main NAD + -consuming enzyme responsible for NAD + levels regulation in tissue and therefore represents a possible therapeutic target in such conditions. Objective: To investigate the role of CD38 in cardiovascular performance and its potential use as a therapeutic target in obesity-induced heart failure. Results: When comparing adult Wild-Type (WT) and CD38 Knock-out (KO) mice we observed that the latter had higher exercise performance, increased heart rate variability (HRV) and decreased heart rate (HR). When comparing WT and CD38 catalytically inactive (CI) mice we observed the same results, showing its relation with CD38 catalytic activity. WT mice treated with an antibody which blocks CD38 activity showed improved exercise capacity and HRV. In both genetically modified or antibody treated groups, NAD+ levels were significantly increased in heart. In order to explore the NAD + role in these findings, we compared WT control and CD38KO treated with FK866 (Nampt inhibitor) and observed that NAD+ levels in heart decreased as well as exercise capacity. We then aimed to demonstrate CD38 role as a target for therapeutic intervention in a model of cardiac strain induced by obesity in aged mice. We compared WT and CD38 CI aged mice, placed in normal diet (ND) or high fat diet (HFD). WT animals fed HFD showed decreased exercise capacity and this effect is reversed in CD38 CI fed HFD. Similarly, WT placed in HFD developed diastolic dysfunction seen as a significant increase in E/e’ ratio, and CD38 CI placed in HFD were protect against the development of this dysfunction. Mechanistically, we observed that blockage of CD38 resulted in decreased protein acetylation and increased SERCA expression. Conclusion: CD38 plays a role in cardiovascular performance by regulation of NAD + homeostasis. In a model of obesity-induced diastolic dysfunction NAD+-boosting by blocking CD38 activity led to protection by up-regulating SERCA expression.
U.S. Cohort Study of Previously Untreated Patients with Congenital Hemophilia (ATHN 8: PUPs Study): Association between Family History and Age of Diagnosis
Authors: Courtney D Thornburg, Kenneth D Friedman, Michael F Guerrera, Chunla He, Lynn M Malec, Mindy L Simpson, Michael D Tarantino, H. Marijke Van Den Berg, Crystal Watson, Shannon L Carpenter
Journal: Blood (2020)
Amahrelis : Adcetris Maintenance after Autologous Stem Cell Transplantation in Hodgkin Lymphoma : A Real Life Study from Sfgmtc and Lysa Groups
Authors: Amira Marouf, Anne Ségolène Cottereau, Guillemette Fouquet, Salim Kanoun, Patricia Franchi, Romain Ricci, Michel Meignan, David Sibon, Thomas Gastinne, Cecile Borel, Mohammad Hammoud, Guillaume Sicard, Romane Gille, Doriane Cavalieri, Aspasia Stamatoulas Bastard, Lauriane Clement-Filliatre, Julien Lazarovici, Adrien Chauchet, Luc Mathieu Fornecker, Sandy Amorin, Mathieu Roquet, Nicole Raus, Rene-Olivier Casasnovas, Guillaume Cartron, Hervé Ghesquieres, Pauline Brice, Olivier Hermine, Didier Bouscary, Marie Thérèse Rubio, Jerome Tamburini, Benedicte Deau Fischer
Journal: Blood (2020)
Distinct Clinical and Genetic Factors Predict Early Versus Late Mortality in AML Patients Undergoing Induction Chemotherapy
Authors: J. Erika Haydu, Yael Flamand, Rahul S. Vedula, Jurjen Versluis, Anne Charles, Kevin Copson, Donna S. Neuberg, R. Coleman Lindsley, Marlise R Luskin
Journal: Blood (2020)
Real World Outcomes of Sars-Cov-2 Thrombosis Rates across Three University Health Systems in the Chicago Metropolitan Area
Authors: Stephanie Berg, Seo-Hyun Kim, Sonam Patel, Priya Rajakumar, Elizabeth Jane Elliott, Candice Schwartz, James Coggan, Amy Wozniak, Yanyu Zhang, Saad Arain, Abhigna Kodali, Daulath Singh, Oluwatobi Odetola, Hina Dalal, Rebecca Feltman Frank, Diana Kreppel, Ellen Murchie, Laura Pax, Ahmed Aleem, Ryan Guerrettaz, Raymond W. Lee, Glenda Delgado-Ramos, Fatema Esmail, Patrick Moore, Shuai Qin, Nicholas Torgerson, Tracie Watson, Kevin Barton, Patrick Hagen, Nasheed Hossain, Anthi Katsouli, Erin M Lowery, Melissa L. Larson, Hanh Mai, Katie W. Phelan, Sucha Nand, Patrick J. Stiff, Santosh L. Saraf
Journal: Blood (2020)
Iron Trafficking through Macrophages Regulates Signaling Pathways in Myeloma
Authors: Xuelian Tan, Timothy Cody Ashby, Yuqi Zhu, Can Li, Xuxing Shen, Qierra Brockman, Dongzheng Gai, Sarah K Johnson, Donghoon Yong, Carolina D. Schinke, Maurizio Zangari, Frits van Rhee, John Shaughnessy, Dingming Huang, Ivana Frech, Guido J. Tricot, Fenghuang Zhan
Journal: Blood (2020)
Reduced-Intensity Versus Myeloablative Conditioning for Allogeneic Hematopoietic Cell Transplantation in Patients with Myelodysplastic Syndrome: A Systematic Review and Meta-Analysis of Randomized Clinical Trials &amp; Cohort Studies
Authors: Arshia Akbar, Zunairah Shah, Muhammad Ali Aziz, Muhammad Yasir Anwar, Saman Bahram, Waqas Khan, Zahoor Ahmed, Qasim Khurshid, Abdul Jabbar Dar, Anum Javaid, Neelam Asghar, Harsh Patel, Faiz Anwer
Journal: Blood (2020)
Nationwide Investigation of Patient Trajectories in Mantle Cell Lymphoma - Initial Data from the Swedish MCL C<i>omplete</i> Project
Authors: Mats Jerkeman, Thorgerdur Palsdottir, Ingrid Glimelius, Alexandra Albertsson-Lindblad, Caroline Weibull, Fredrik Ellin, Kristina Sonnevi, Catharina Lewerin, Lena Brandefors, Karin E. Smedby
Journal: Blood (2020)
Abstract MP175: Disruption of the Genome Architecture at the <i>PRRX1</i> Locus is Associated With the Pathogenesis of <i>LMNA</i> -related Dilated Cardiomyopathy
Authors: Yuan Zhang, Mohamed Ameen, Isaac Perea Gil, Jennifer Arthur, Alexandra A Gavidia, Nike Bharucha, Kevin C Wang, Ioannis Karakikes
Journal: Circulation Research (2020)

Background: LMNA , a gene encoding A-type lamin proteins (abbreviated as lamin A), is one of the most frequently mutated genes in dilated cardiomyopathy (DCM). The molecular mechanisms underlying cardiomyocyte dysfunction in LMNA -related DCM remain elusive, translating to the lack of disease-specific therapies. Lamin A has been shown to play a critical role in genome organization via interactions with the chromatin at specific regions called lamina-associated domains (LADs). However, little is known about whether DCM-causing LMNA mutations rearrange the genome conformation and chromosome accessibility. The overarching goal of this study is to define the role of genome organization in LMNA -related DCM. Methods: LMNA -related DCM was modeled in vitro using cardiomyocytes derived from induced pluripotent stem cells (iPSC-CMs) from DCM patients carrying a frameshift mutation in the LMNA gene (c. 348_349insG; p. K117fs) and isogenic controls. We combined genome-wide single cell functional genomic and epigenomic mapping analyses to define the gene regulation and cis-regulatory interactions in isogenic iPSC-CMs. Results: Single-cell RNA-seq revealed global gene dysregulation in LMNA mutant compared to isogenic control iPSC-CMs. The homeodomain transcription factor PRRX1 was significantly upregulated in mutant cells. We showed that LAD integrity is disrupted at the PRRX1 locus in mutant iPSC-CMs. In agreement, DNA fluorescence in situ hybridization (FISH) revealed that the PRRX1 locus loses peripheral association and relocates towards the transcriptionally active nuclear interior in mutant iPSC-CMs. Correspondingly, single-cell assay for transposase accessible chromatin (ATAC)-seq showed increased chromatin co-accessibility at the PRRX1 locus, providing a plausible explanation for ectopic activation of PRRX1 in LMNA mutant iPSC-CMs. Conclusion: Our data suggest that LMNA haploinsufficiency disrupts the structure of LADs, leading to ectopic promoter interactions and altered gene expression in LMNA -related DCM iPSC-CMs. We identified PRRX1 as a promising candidate locus linking changes in LAD organization with gene dysregulation in LMNA -related DCM.
Abstract 398: Magnitude and Impact of Underutilization of Flu Vaccine in High-Risk US Cohorts on Cardiovascular Events
Authors: ROSHNI A MANDANIA, Arjab Ghosh, Jennifer Ma, miguel mena, Christopher Dodoo, Luis Alvarado, Alok Dwivedi, Debabrata Mukherjee
Journal: Circulation Research (2020)

Background: Influenza vaccination has been shown to reduce myocardial infarction(MI) and other cardiac events. Several groups are considered at high risk for influenza and its complications. In this study, we explored the utilization and impact of flu vaccination in these high risk groups on various cardiovascular outcomes. Methods: Our retrospective cohort study compared utilization and outcomes in high risk groups among those who did receive vaccination during hospitalization versus those who did not. We analyzed utilization and impact of flu vaccine in several high-risk group identified by Center for Disease Control (CDC) i.e., adults 50 years and older, people with chronic medical conditions, AIDS patients, people at nursing facilities, American Indians and Alaskan natives, and obese people in the 2014 National Inpatient Sample Database. Results: The NIS database revealed 168,325 flu vaccinations among the 7,056,314 total high risk patients during hospitalization. Of note, the adults 50 years and older high risk cohort was less likely to be vaccinated during hospitalization at 1.8% compared to the general population at 15.3%. High risk groups benefited with flu vaccination and had reduced risk of MI, mortality, transient ischemic attacks (TIA) and cardiac arrest (Table). Conclusion: Flu vaccination was paradoxically underutilized in the high-risk patients and when used was associated with reduced rates of MI, TIA and cardiac arrest in all high risk cohorts compared to those who did not receive vaccination. These results underscore the need for health care policy initiatives to optimize flu vaccination among all patients and especially among high risk groups identified by the CDC.
Helen Salisbury: Mourning meetings
Authors: Helen Salisbury
Journal: BMJ (2020)

In pre-covid days, I would walk out to the waiting room to fetch each patient. This benefited my health (too much uninterrupted sitting is bad for you), provided a moment for greetings and pleasantries, and allowed me to observe how patients moved. Delaying the main purpose of the visit until we were inside my consulting room, we might talk about the weather or any number of other topics as a preamble to more serious conversation.

I miss this social glue. Small talk also serves a larger purpose: it helps to build a rapport and put patients at ease. On the telephone, I’m …