tbuckley/cabot-search huggingface dataset:
AB1204 BURDEN DISEASE OF LOW BACK PAIN IN COLOMBIA, 2015
Authors: Francy Cuervo, Juan Camilo Rueda, Ana María Santos, Eugenia-Lucia Saldarriaga, Ignacio Angarita, Rodrigo Giraldo, Ingris Peláez-Ballestas, Diana Díaz-Jiménez, Jesús G. Ballesteros, Pedro Santos-Moreno, Diana Padilla-Ortiz, Viviana Reyes, Carlos Castañeda-Orjuela, John Londono
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background:</h3> Low back pain (LBP) is the second most frequent rheumatic disease in Colombia. According to the COPCORD study, LBP prevalence was 7.24% (CI 95% 6.28-8.34%) (1). <h3>Objectives:</h3> To estimate the disease burden of LBP for 2015. <h3>Methods:</h3> A descriptive study was conducted. A Markov model was developed based on cases with LBP, distribution of disability and mortality according to DANE (Departamento Administrativo Nacional de Estadistica) and the WHO (World Health Organization) reference data. The results are shown in terms of the years of life lost due to premature mortality (YLL), years lived with disability (YLD) and finally as Disability-Adjusted Life Year (DALY). <h3>Results:</h3> The distribution of cases by age of LBP are shown in figure 1. An algorithm was designed to determine the distribution in percentages of severity levels, according to the GBD definitions (figure 2). According to ICD-10 codes, 9 deaths were reported, so the YLL were 124. The YLDs were 264,658. Finally, the DALYs were 264,782 for a rate of 808.82 per 100,000, which is higher than the GBD 2016 results (647 per 100,000). <h3>Conclusion:</h3> The main cause of burden disease of rheumatic disease in Colombia is due to LBP. The burden is because of the YLD, related to the frequency of cases in people younger than 50 years of age. It is necessary for an early detection and development of intervention strategies. <h3>References</h3> [1] Londono J, Peláez I, Cuervo F, et al. Prevalencia de la enfermedad reumática en Colombia, según estrategia COPCORD-Asociación Colombiana de Reumatología. Estudio de prevalencia de enfermedad reumática en población colombiana mayor de 18 años. Rev Colomb Reum [Internet]. 2018;1–12. Available from: https://doi.org/10.1016/j.rcreu.2018.08.003 <h3>Disclosure of Interests:</h3> Francy Cuervo: None declared, Juan Camilo Rueda: None declared, Ana María Santos: None declared, Eugenia-Lucia Saldarriaga: None declared, Ignacio Angarita: None declared, Rodrigo Giraldo: None declared, Ingris Peláez-Ballestas: None declared, Diana Díaz-Jiménez: None declared, Jesús G Ballesteros: None declared, Pedro Santos-Moreno Grant/research support from: Dr Santos has received research grants from Janssen, Abbvie and UCB, Speakers bureau: Dr Santos has received speaker fees from Sanofi, Lilly, Bristol, Pfizer, Abbvie, Janssen and UCB, Diana Padilla-Ortiz: None declared, Viviana Reyes: None declared, Carlos Castañeda-Orjuela: None declared, John Londono: None declared
Abstract P247: Dietary Intake and Peripheral Arterial Disease Incidence in Middle Aged Adults: the Atherosclerosis Risk in Communities Study (ARIC)
Authors: Rachel P Ogilvie, Pamela L Lutsey, Gerardo Heiss, Aaron R Folsom, Lyn M Steffen
Journal: Circulation (2017)

Background: Peripheral arterial disease (PAD) is a costly source of morbidity and mortality among older persons in the United States. Dietary intake plays a role in the development of atherosclerotic cardiovascular disease; however, few studies have examined the relation of food intake or diet patterns with PAD. Objectives: We examined the relationship between habitual dietary intake at midlife and incident PAD over approximately 20 years of follow-up. Methods: Among 14,082 participants enrolled in the Atherosclerosis Risk in Communities (ARIC) study initially free of PAD, dietary intake was assessed at baseline in 1987-1989 using a Harvard food frequency questionnaire. Food groups were created and principal components analysis was used to develop “healthy” and “Western” dietary patterns; both were categorized into quintiles or quartiles. Incident PAD was defined by an ankle-brachial index (ABI) measure of &lt; 0.90 at either of two subsequent exams (1993-1995, 1996-1998), or a hospital discharge diagnosis of PAD, leg amputation, or leg revascularization procedures through 2012. Cox proportional hazards models adjusted for relevant confounders assessed the relations of each food group or diet pattern with incident PAD. Results: During a mean follow up of 19.9 years, 1569 participants developed incident PAD. A total of 64.7% of cases had their incident event defined via ICD-9 codes, while 35.3% had incident PAD defined by ABI. In models adjusted for demographics, behaviors, and food groups, the hazard ratios for incident PAD increased across quintiles of meat consumption (Q2 vs. Q1 1.38 [95% CI 1.16, 1.64], Q3 vs. Q1 1.40 [1.18, 1.67], Q4 vs. Q1 1.47 [1.23, 1.77], Q5 vs. Q1 1.66 [1.36, 2.03], p for trend &lt;0.001). Compared to those who drank no alcohol, those who had 1-6 drinks per week had a lower risk of incident PAD (HR=0.78 [95% CI 0.68, 0.89]). For coffee, there was a modest inverse association with incident PAD (Q5 vs. Q1 0.84 [0.75, 1.00], p for trend = 0.014). There was no association between other food groups or patterns and incident PAD. Conclusions: In this prospective population-based cohort study, greater meat consumption was associated with higher risk of incident PAD, while both moderate alcohol consumption and coffee consumption were associated with lower risk of incident PAD. Whether these associations are causal remains to be seen.
AB0346 TREND OVER TIME OF AORTIC STIFFNESS IN RHEUMATOID ARTHRITISPATIENTS AND ITS RELATION WITH CARDIOVASCULAR EVENTS
Authors: Giovanni Orsolini, Giovanni Cioffi, Alessandro Giollo, Federica Ognibeni, Andrea Dalbeni, Davide Gatti, Angelo Fassio, Giulia Bonasera, Maurizio Rossini, Ombretta Viapiana
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> Ascending aorta has an increased stiffness (AoSI) in rheumatoid arthritis (RA) patients due to their chronic inflammatory status. We assessed prevalence and modification of AoSI during a follow up period and its prognostic role on cardiovascular events (CVE) in a large cohort of RA patients <h3>Objectives</h3> Prognostic role of AoSI and its modification over time on CVE. <h3>Methods</h3> We prospectively followed 146 RA patients without overt cardiac disease with periodic echocardiographic examination. Abnormally high AoSI was diagnosed if AoSI &gt; 6.07% (95th percentile of the AoSI detected in our reference healthy population). AoSI was assessed at the level of the aortic root by two-dimensional guided M-mode evaluation as part of a thorough echocardiography performed in all patients. CVE information were collected during follow up <h3>Results</h3> Of our 146 RA patients, 89 had a normal AoSI at baseline, in the remaining 57 it was abnormally high. After a mean follow up of 27 months: among patients with normal baseline AoSI it stayed normal in 64 (6 to 5,6%) and in 25 raised to an abnormal high AoSI (from 3,7 to 11,9%); of the 57 patients with high baseline AoSI, 33 went back to normal values (9,4 to 3,1%) and in 24 it remained high. Of these 4 groups divided by AoSI trend over time the group with de novo high AoSI showed the highest prevalence of new CVE (33%), together with the group with persistent high AoSI (16%). Much lower prevalence was observed in the other two groups (persistent normal 5%, normalized at follow up 6%). <h3>Conclusion</h3> Abnormally high AoSI is common in RA patients, rapid increase through time or persistent high AoSI identify those patients that are more prone to develop CVE. On the contrary, patients that showed a normalization of AoSI demonstrated to have a similar low incidence of CVE as patients who ever had a normal AoSI. <h3>Disclosure of Interests</h3> Giovanni Orsolini Speakers bureau: Grunenthal, Giovanni Cioffi: None declared, Alessandro Giollo: None declared, Federica Ognibeni: None declared, Andrea Dalbeni: None declared, Davide Gatti Speakers bureau: Abiogen, Amgen, Janssen-Cilag, Mundipharma, Pfeizer, Angelo Fassio Speakers bureau: Abiogen Pharma, Giulia Bonasera: None declared, Maurizio Rossini: None declared, Ombretta Viapiana Speakers bureau: Novartis, Abbvie, Eli-Lilly, Sanofi Genzyme
Disturbed Yin–Yang balance: stress increases the susceptibility to primary and recurrent infections of herpes simplex virus type 1
Authors: Chang Yan, Zhuo Luo, Wen Li, Xue Li, Robert Dallmann, Hiroshi Kurihara, Yi-Fang Li, Rong-Rong He
Journal: Acta Pharmaceutica Sinica B (2019)

Herpes simplex virus type 1 (HSV-1), a neurotropic herpes virus, is able to establish a lifelong latent infection in the human host. Following primary replication in mucosal epithelial cells, the virus can enter sensory neurons innervating peripheral tissues via nerve termini. The viral genome is then transported to the nucleus where it can be maintained without producing infectious progeny, and thus latency is established in the cell. Yin-Yang balance is an essential concept in traditional Chinese medicine (TCM) theory. Yin represents stable and inhibitory factors, and Yang represents the active and aggressive factors. When the organism is exposed to stress, especially psychological stress caused by emotional stimulation, the Yin-Yang balance is disturbed and the virus can re-engage in productive replication, resulting in recurrent diseases. Therefore, a better understanding of the stress-induced susceptibility to HSV-1 primary infection and reactivation is needed and will provide helpful insights into the effective control and treatment of HSV-1. Here we reviewed the recent advances in the studies of HSV-1 susceptibility, latency and reactivation. We included mechanisms involved in primary infection and the regulation of latency and described how stress-induced changes increase the susceptibility to primary and recurrent infections.
Detection of plasmid-mediated tigecycline-resistant gene tet(X4) in Escherichia coli from pork, Sichuan and Shandong Provinces, China, February 2019
Authors: Li Bai, Pengcheng Du, Yinju Du, Honghu Sun, Pei Zhang, Yuping Wan, Qi Lin, Séamus Fanning, Shenghui Cui, Yongning Wu
Journal: Eurosurveillance (2019)

The plasmid-mediated high-level tigecycline resistance gene, tet(X4), was detected in seven Escherichia coli isolates from pork in two Chinese provinces. Two isolates belonged to the epidemic spreading sequence type ST101. Tet(X4) was adjacent to ISVsa3 and concurrent with floR in all seven isolates. In addition to IncFIB, the replicon IncFII was found to be linked to tet(X4). This report follows a recent detection of tet(X3)/(X4) in E. coli from animals and humans in China.
PB1834 PRALATREXATE EXPERIENCE IN NON HODGKIN LYMPHOMA
Authors: L. Enciso‐Olivera, B. Patiño, M. Diaz, H. Martinez, D. Otero, P. Spirko, C. Acon
Journal: HemaSphere (2019)

Please indicate where the abstract has been published before: Third National Congress of clinical investigation. Colombian Association of Oncology and Hematology (ACHO) Background: Pralatrexate is an antimetabolite used mainly in the treatment of relapsed or refractory peripheral T‐cell lymphoma. However, due to its low prevalence rate, and a small population analyzed in the trials, there is not a trial which evaluated results in ordinarily practice in our knowledge. Aims: To study the treatment with Pralatrexate in a 10 patients series with T‐cell lymphoma, both nodal and cutaneous, attended in our institution. Methods: Case series. Patients older than 18 years old, with a diagnosis of T‐Cell lymphoma, any subtype, treated with at least one cycle of Pralatrexate with available information for following up and treatment evaluation. All the analysis were made in the statistic package R (Version 3.4.3) and STATA 15. Results: Ten patients were included, 50% were men. The median was 47.8 years (IQR 17.04). The 50% had a Mycosis Fungoides (MF) diagnostic, being the most frequent histologic type. Five patients had the diagnosis of T Cell Lymphoma NOS which, one (10%) T cell Lymphoma ALK‐negative, one (10%) angioimmunoblastic lymphoma and one (10%) primary cutaneous anaplastic lymphoma. All the patients had received a prior treatment based on anthracyclines. The number of treatment received prior to the Pralatrexate beginning was a mean of 2,8 (SD 1.03). The 30% (three patients) suffered grade 3 mucositis in at least one cycle. Four patients required to be admitted at least in a cycle due to complications related to the treatment, and a patient required to be admitted in an intensive care unit requiring vasopressor support. None opportunistic infections were reported nor febrile neutropenia related to the other treatment cycles. A patient (10%) reached out complete response, two patients were in stable disease. Six patients (60%) progressed during the treatment after a mean of 2.8 cycles (1 to 4). At the last evaluation time, five (50%) of patients had started a new treatment line. Summary/Conclusion: The pralatrexate treatment in our patients with T cell lymphoma diagnosis offers a low response and short duration rates. Despite its good tolerance, also there is a high risk of complications, mainly mucositis.
sppIDer: A Species Identification Tool to Investigate Hybrid Genomes with High-Throughput Sequencing
Authors: Quinn K Langdon, David Peris, Brian Kyle, Chris Todd Hittinger
Journal: Molecular Biology and Evolution (2018)

The genomics era has expanded our knowledge about the diversity of the living world, yet harnessing high-throughput sequencing data to investigate alternative evolutionary trajectories, such as hybridization, is still challenging. Here we present sppIDer, a pipeline for the characterization of interspecies hybrids and pure species, that illuminates the complete composition of genomes. sppIDer maps short-read sequencing data to a combination genome built from reference genomes of several species of interest and assesses the genomic contribution and relative ploidy of each parental species, producing a series of colorful graphical outputs ready for publication. As a proof-of-concept, we use the genus Saccharomyces to detect and visualize both interspecies hybrids and pure strains, even with missing parental reference genomes. Through simulation, we show that sppIDer is robust to variable reference genome qualities and performs well with low-coverage data. We further demonstrate the power of this approach in plants, animals, and other fungi. sppIDer is robust to many different inputs and provides visually intuitive insight into genome composition that enables the rapid identification of species and their interspecies hybrids. sppIDer exists as a Docker image, which is a reusable, reproducible, transparent, and simple-to-run package that automates the pipeline and installation of the required dependencies (https://github.com/GLBRC/sppIDer; last accessed September 6, 2018).
Abstract 14263: Pyruvate Dehydrogenase Kinase 4 Leads to Reduced Endothelial-pericyte Interactions in Pulmonary Arterial Hypertension
Authors: Ke Yuan, Ningyi Shao, Jan Hennigs, Mark Orcholski, Alice Richter, Joseph Wu, Vinicio de Jesus Perez
Journal: Circulation (2015)

Introduction: Pulmonary arterial hypertension (PAH) is a life-threatening disorder characterized by impaired angiogenesis, progressive small vessel loss and occlusive vasculopathy. Pericyte recruitment and establishment of endothelial-pericyte interactions is a critical event to ensure structural integrity and proper function of new vessels. Studies by our group and others have shown that establishment of endothelial-pericyte interactions is reduced in PAH and results in impaired but the mechanisms underlying this defect remain poorly understood. In an effort to identify relevant gene candidates associated with aberrant pericyte behavior, we performed a transcriptome analysis of healthy and PAH lung pericytes followed by computational network analysis. Hypothesis: PAH pericytes have increased genes involved in cell cycle progression, growth and motility. Methods: Pericytes were extracted from lungs of healthy (N=6) and PAH (N=6) patients followed by lineage validation using FACS and functional assays. RNA extracted from pericytes was converted into cDNA and used in Illumina microarrays. Expression of top candidate genes was validated in histological sections and purified lung using Taqman qPCR, western blot and immunofluorescence. Results: Pyruvate dehydrogenase kinase isozyme 4 (PDK4), which suppresses mitochondrial glucose oxidation in favor of anaerobic glycolysis, demonstrated the greatest upregulation in PAH pericytes. Compared to healthy cells, PAH pericytes had higher rate of glycolysis but reduced mitochondrial oxygen consumption and reactive oxygen species (ROS) production using Seahorse analysis. Treatment with PDK4 siRNA in PAH pericytes increased the rate of mitochondrial glucose oxidation, endothelial tube formation and motility. Conclusions: This is the first study demonstrating differences in gene expression profile that correlate with aberrant pericyte behavior during establishment of endothelial pericyte interactions in PAH. PDK4 inhibitor in PAH may reverse vascular remodeling and help protect against microvessel loss. Efforts to assess the relevance of other altered genes in PAH pericytes could lead to insights into PAH pathobiology and the identification of novel therapeutic targets.
THU0691 CLINICAL, RADIOLOGICAL, THERAPEUTIC ASPECT AND PROGNOSTIC OF INFECTIOUS SPONDYLODISCITIS WITHOUT BACTERIOLOGICAL EVIDENCE
Authors: Rawdha Tekaya, Lobna Ben Ammar, Aicha Ben Tekaya, Khaoula Zouaoui, Olfa Saidane, Ines Mahmoud, Leila Abdelmoula
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Background</h3> Early microbiological diagnosis and multidisciplinary management are the main predictive factor for successful treatment in septic spondylitis. However, the therapeutic management of spondylodiscitis without bacteriological diagnosis is not well codified. <h3>Objectives</h3> To evaluate whether there is clinical, biological or significant imaging between patients with infectious sondylodiscitis as they had or not a microbiological diagnosis. <h3>Methods</h3> Retrospective study including 107 patients hospitalized in our department between 1999 and 2018. The diagnosis was based on clinical, biological, radiological and bacteriological data. <h3>Results</h3> This study involved 107 patients, including 58 men (54.2%) and 49 women (45.8%) with a mean age of 55 years [16–86]. Spinal pain was observed in all cases and the lumbar spine was most affected (54.2%). A neurological deficit was noted in 16.82% of cases. The inflammatory syndrome was present in 90.6% of cases. Radiographs of the spine were abnormal in 83.1% of cases. CT and Spinal MRI were performed respectively in 60% and 78.8% of cases. Disco vertebral biopsy was performed in 73 patients and was contributory in 46.5% of cases. We divided patients into two groups: patients with a confirmed biological diagnosis (group 1: 45.3%) versus patients in whom the diagnosis had been held on presumptive criteria (group2: 54.2%). There was no statically significant difference in the age (p=0.5), sex (p=0.3), risk factors such as diabetes (p=0.8), the start mode (p= 0.4), the presence of an impaired general condition (p=0.3), night sweats (p=0.1) and a neurological deficit (p=0.8), biological parameters (p=0.3) and the occurrence of complications (p=0.09) between the two groups. Vertebral condensation in radiographs of the spine was higher in group 2 and this was statically significant (p=0.03). In addition, the consumption of unpasteurized milk and positivity of wright serology was higher in the first group (p= 0.001 and p&lt;0.001; respectively). Similarly, contributive histological result of vertebral biopsy was more frequent in group 1 (p=0.007). <h3>Conclusion</h3> Diagnosing infectious spondylodiscitis is facilitated by improved access to MRI testing. However, microbiological diagnosis is the main key to a successful management of this life threatening infection. <h3><b>Disclosure of Interests:</b>&nbsp;</h3> &nbsp; None declared
Mental illness: outgoing PM announces prevention plan
Authors: Jacqui Wise
Journal: BMJ (2019)

NHS staff, teachers, and social workers will get training to spot the signs of mental health problems, under a new prevention plan announced by the outgoing prime minister, Theresa May.

In an attempt to cement her domestic legacy in her last few days in office, May announced a package of measures to tackle what she called the “burning injustice” of mental illness. “We should never accept a rise in mental health problems as inevitable,” she said. “It’s time to rethink how we tackle this issue, which is why I believe the next great revolution in mental health should be in prevention.”

May also confirmed …
Abstract P321: Pregnancy Loss is Associated With Subclinical Cardiovascular Disease in Mexican Women
Authors: Sandra A Hartasanchez, Mario Flores, Adriana Monge, Elsa Yunes, Carlos Cantu-Brito, Luis Espinosa, Ruy Lopez-Ridaura, Martin Lajous
Journal: Circulation (2017)

Introduction: Cardiovascular disease (CVD) in women often develops in the absence of conventional risk factors. Prenatal loss, a common pregnancy outcome, may result in physiologic changes that could affect future risk of myocardial infarction. Little is known about the impact of pregnancy loss on early markers of CVD risk. Hypothesis: Pregnancy loss affects carotid artery intima-media thickness (CIMT). Methods: We conducted a cross-sectional analysis among 1,769 disease-free women from the Mexican Teachers’ Cohort who had been pregnant to evaluate the relation between pregnancy loss and CIMT. In 2008 participants answered a baseline questionnaire on reproductive history, risk factors for chronic disease and medical conditions that was updated in 2011. We defined pregnancy loss as abortion and/or stillbirth. Between 2012 and 2016, CIMT was measured by trained neurologists using ultrasound in three clinical sites. We log-transformed CIMT and defined carotid atherosclerosis as CIMT ≥0.8mm or plaque. We used multivariable linear and logistic regression models to assess the relation between pregnancy loss, CIMT and carotid atherosclerosis. Results: Mean age of participants was 49.8 (SD ± 5.1) years. The prevalence of pregnancy loss was 22% (394 of 1769) , while we observed carotid atherosclerosis in 23% (405 of 1769) of participants. Comparing participants who reported a pregnancy loss to those who did not, the multivariable-adjusted odds ratio for carotid atherosclerosis was 1.52 (95% CI 1.12, 2.06). Women who experienced a stillbirth had 2.32 higher odds (95% CI 1.03, 5.21) of carotid atherosclerosis than those who did not. Mean CIMT appeared to be higher in women who reported a pregnancy loss relative to those who did not, however, in multivariable analyses, pregnancy loss and stillbirth were not significantly associated with CIMT. Conclusions: Abortion and stillbirth may be associated with a higher risk of CVD. Additional investigation on potential underlying mechanisms for this association is required.
Predicting double-strand DNA breaks using epigenome marks or DNA at kilobase resolution
Authors: Raphaël Mourad, Krzysztof Ginalski, Gaëlle Legube, Olivier Cuvier
Journal: Genome biology (2018)

Double-strand breaks (DSBs) result from the attack of both DNA strands by multiple sources, including radiation and chemicals. DSBs can cause the abnormal chromosomal rearrangements associated with cancer. Recent techniques allow the genome-wide mapping of DSBs at high resolution, enabling the comprehensive study of their origins. However, these techniques are costly and challenging. Hence, we devise a computational approach to predict DSBs using the epigenomic and chromatin context, for which public data are readily available from the ENCODE project. We achieve excellent prediction accuracy at high resolution. We identify chromatin accessibility, activity, and long-range contacts as the best predictors.
A deletion mutation in TaHRC confers Fhb1 resistance to Fusarium head blight in wheat
Authors: Zhenqi Su, Amy Bernardo, Bin Tian, Hui Chen, Shan Wang, Hongxiang Ma, Shibin Cai, Dongtao Liu, Dadong Zhang, Tao Li, Harold Trick, Paul St. Amand, Jianming Yu, Zengyan Zhang, Guihua Bai
Journal: Nature Genetics (2019)