tbuckley/cabot-search huggingface dataset:
The conventional protocol vs. a protocol including illumination with a fabric‐based biophotonic device (the Phosistos protocol) in photodynamic therapy for actinic keratosis: a randomized, controlled, noninferiority clinical study
Authors: S. Mordon, A.S. Vignion‐Dewalle, H. Abi‐Rached, E. Thecua, F. Lecomte, C. Vicentini, P. Deleporte, H. Béhal, D. Kerob, T. Hommel, A. Duhamel, R.M. Szeimies, L. Mortier
Journal: British Journal of Dermatology (2019)

Topical photodynamic therapy (PDT) using methyl aminolaevulinate is a noninvasive treatment option suitable to treat clinical and subclinical actinic keratosis (AK) over a large area (field cancerization). The most widely used, conventional protocol in Europe includes illumination with a red-light lamp. This illumination commonly causes pain, and patients often cannot complete the treatment.The aims of this paper are twofold. The first aim is to introduce a novel protocol, the Phosistos protocol (P-PDT), which includes illumination with a fabric-based biophotonic device. The second and major aim is to assess the noninferiority, in terms of efficacy for PDT of AK, of P-PDT compared with the conventional protocol (C-PDT).A randomized, controlled, multicentre, intraindividual clinical study was conducted. Forty-six patients with grade I-II AK of the forehead and scalp were treated with P-PDT on one area (280 AK lesions) and with C-PDT on the contralateral area (280 AK lesions). The primary end point was the lesion complete response (CR) rate at 3 months, with an absolute noninferiority margin of -10%. Secondary end points included pain scores, incidence of adverse effects and cosmetic outcome.Three months following treatment, the lesion CR rate of P-PDT was noninferior to that of C-PDT (79·3% vs. 80·7%, respectively; absolute difference -1·6%; one-sided 95% confidence interval -4·5% to infinity). The noninferiority of P-PDT to C-PDT in terms of the lesion CR rate remained at the 6-month follow-up (94·2% vs. 94·9%, respectively; absolute difference -0·6%; one-sided 95% confidence interval -2·7% to infinity). Moreover, the pain score at the end of illumination was significantly lower for P-PDT than for C-PDT (mean ± SD 0·3 ± 0·6 vs. 7·4 ± 2·3; P < 0·001).P-PDT is noninferior to C-PDT in terms of efficacy for treating AK of the forehead and scalp and resulted in much lower pain scores and fewer adverse effects. What's already known about this topic? Topical photodynamic therapy using methyl aminolaevulinate is effective for treating actinic keratosis. In Europe, the conventional protocol involves illumination with a red-light lamp. Unfortunately, pain is often experienced by patients undergoing this protocol. An alternative protocol that uses daylight illumination has recently been shown to be as effective as the conventional protocol while being nearly painless. However, this alternative protocol can be conducted only in suitable weather conditions. What does this study add? The Phosistos protocol is demonstrated to be as effective as the conventional protocol, nearly as painless as the daylight protocols and suitable year round for treatment of actinic keratosis.
Abstract 17810: The Sarcopenic Diabetic Phenotype Exacerbates Left Atrial Function Associated With Sarcopenic Aging
Authors: Hannah H Chew, Vivian J Chow, Bryan M Keng, Ru San Tan, Shuang Leng, Xiaodan Zhao, Liang Zhong, Fei Gao, Woon-Puay Koh, Angela S Koh
Journal: Circulation (2017)

Introduction: The link between skeletal muscle and heart disease remains intriguing and incompletely understood, particularly among aged cohorts where processes of sarcopenia may co-exist in tandem with cardiovascular (CV) aging. Hypothesis: Given that sarcopenia may be common to both diabetes mellitus (DM) and aging, we hypothesize that a more severe pattern of CV aging is present among diabetics aged adults with sarcopenia. Methods: We studied elderly community based participants without CVD or cancer. We used cardiac magnetic resonance (CMR) feature tracking (FT) to focus our investigation on left atrial (LA) phasic function, known to be a sensitive marker of CV function. Longitudinal LA strain comprising reservoir strain (es), conduit strain (ee) and booster strain (ea) and their corresponding peak strain rates (SRs, SRe, SRa) were measured. Body composition analyser was used to measure skeletal muscle mass (SMM, in kilograms (kg)) in sites such as trunk, upper limb and lower limb. Sarcopenia was defi...
EPEN-13. OUTCOMES AFTER FIRST RELAPSE OF CHILDHOOD INTRACRANIAL EPENDYMOMA: A SINGLE INSTITUTION EXPERIENCE
Authors: Neevika Manoharan, Mary Ann Zimmerman, Jacqueline Scully, Christine Chordas, Jessica Clymer, Karen Wright, Mariella Filbin, Nicole J Ullrich, David Munn, Theodore Johnson, Susan Chi, Pratiti Bandopadhayay, Kee Kiat Yeo
Journal: Neuro-Oncology (2019)

INTRODUCTION: Ependymoma is the third commonest malignant CNS tumor in children. Despite multimodal therapy, prognosis of relapsed ependymoma remains poor with long-term progression-free survival (PFS) of approximately 30%. Approaches to treating relapsed ependymoma are extremely varied. Here, we describe our experience and clinical outcomes of children after first relapse of intracranial ependymoma. METHODS: We performed a retrospective, IRB approved, chart review of patients with recurrent intracranial ependymoma treated at Dana-Farber / Boston Children’s Cancer and Blood Disorder Center from 1990 to 2017. RESULTS: Thirty-four patients with relapsed intracranial ependymoma (12 ST, 21 PF, 1 metastatic) were identified. Median time-to-first-relapse was 13.7 months (range:2.0–53.8). Eight patients had metastatic disease at first relapse. Five-year PFS and overall survival (OS) after first relapse was 23.5% and 60.9%, respectively. Median PFS and OS were 12 months and 66 months. Treatments for first relapse included surgery, radiation and/or chemotherapy/biologic therapy. GTR and localized disease were associated with improved OS on univariate analysis, with GTR being an independent prognostic factor for PFS and OS on multivariate analysis (p=0.02 & 0.013, respectively). Median PFS and OS for patients with GTR was 1.5 and 13 years, respectively (versus 0.4 and 2.3 years for STR / no resection [p=0.023 & 0.001, respectively]). Eighteen patients received radiation at first relapse (14 focal radiation, 8 re-irradiation). Patients who were radiated/re-irradiated at relapse showed longer median PFS and OS, however, these did not meet statistical significance. Chemotherapeutic (n=16) and biologic agents (n=3) used in this cohort were heterogenous and did not significantly impact outcome. Median time-to-second-relapse was 10.2 months (range:2.0–124.8). CONCLUSION: Relapsed intracranial ependymoma has a poor prognosis and unrelenting chronic course despite multimodal therapy. GTR is associated with improved outcomes after first relapse and should be pursued when possible. Novel therapeutic strategies are needed for this disease.
A Highly Efficient Colorimetric Immunoassay Using a Nanocomposite Entrapping Magnetic and Platinum Nanoparticles in Ordered Mesoporous Carbon
Authors: Moon Il Kim, Youngjin Ye, Min‐Ah Woo, Jinwoo Lee, Hyun Gyu Park
Journal: Advanced Healthcare Materials (2013)

Nanocomposite to achieve ultrafast immunoassay: A new synergistically integrated nanocomposite consisting of magnetic and platinum nanoparticles, simultaneously entrapped in mesoporous carbon, is developed as a promising enzyme mimetic candidate to achieve ultrafast colorimetric immunoassays. Using new assay system, clinically important target molecules, such as human epidermal growth factor receptor 2 (HER2) and diarrhea-causing rotavirus, can be detected in only 3 min at room temperature with high specificity and sensitivity. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
SCHEDULED INSERTION OF SELF-EXPANDING METAL STENT (SEMS) OF COLON IN SUBOCLUSION SECONDARY TO COLORECTAL CANCER. PRELIMINARY RESULTS
Authors: P Diez Redondo, H Núñez Rodriguez, R Torres, M Pérez-Miranda
Journal: Endoscopy (2019)

To analyze the efficacy and safety of early insertion of SEMS in patients with malignant colonic obstruction that does not allow the passage of the colonoscope but without acute obstructive symptoms.
How Microbes Shape Their Communities? A Microbial Community Model Based on Functional Genes
Authors: Xiaoqing Jiang, Xin Li, Longshu Yang, Chunhong Liu, Qi Wang, Weilai Chi, Huaiqiu Zhu
Journal: Genomics Proteomics & Bioinformatics (2019)

Abstract Exploring the mechanisms of maintaining microbial community structure is important to understand biofilm development or microbiota dysbiosis. In this paper, we propose a functional gene-based composition prediction (FCP) model to predict the population structure composition within a microbial community. The model predicts the community composition well in both a low-complexity community as acid mine drainage (AMD) microbiota, and a complex community as human gut microbiota. Furthermore, we define community structure shaping (CSS) genes as functional genes crucial for shaping the microbial community. We have identified CSS genes in AMD and human gut microbiota samples with FCP model and find that CSS genes change with the conditions. Compared to essential genes for microbes, CSS genes are significantly enriched in the genes involved in mobile genetic elements, cell motility, and defense mechanisms, indicating that the functions of CSS genes are focused on communication and strategies in response to the environment factors. We further find that it is the minority, rather than the majority, which contributes to maintaining community structure. Compared to health control samples, we find that some functional genes associated with metabolism of amino acids, nucleotides, and lipopolysaccharide are more likely to be CSS genes in the disease group. CSS genes may help us to understand critical cellular processes and be useful in seeking addable gene circuitries to maintain artificial self-sustainable communities. Our study suggests that functional genes are important to the assembly of microbial communities.
Opioid Prescription After Surgery—Reply
Authors: Ryan Howard, Michael Englesbe, Joceline Vu
Journal: JAMA Surgery (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
IMMU-15. ALLOGENIC MACROPHAGES IMMUNOTHERAPY IN A MOUSE MODEL OF GLIOBLASTOMA
Authors: Zijian Zhang Zhang, Anthony Bastian Bastian, Daewoo Hong, Jamil Espinal, Cara Orji, Soyoon Lee, Huanyu Dou
Journal: Neuro-Oncology (2019)

Human glioma tumors are immunosuppressive, and evade immune response through a variety of inhibitory pathways. Major challenges in immunotherapy include glioma-associated immune resistance, central nervous system immune privilege, and tumor antigen-specific immune responses, and. Therefore, overcoming immune resistances plays a key role in developing effective immunotherapy. Allograft within the tumor site actively turns off tumor-associated immunosuppression and turns on therapeutic immune responses. We treated the glioblastoma mice with an advanced immunotherapy by inoculation of tumor antigen loaded allogenic macrophages into tumor site. Flow cytometry assay indicated that the increases of CD8+ and CD4+ T cells and CD11b+/Ly6c+ and CD11b+/CD11c+ macrophages in challenged hemisphere. Glioblastoma induced splenic CD4+CD25+Foxp3+ cells were diminished in treated glioblastoma mice. However, the suppressive activity of CD11b+Ly6C+ cells, and CD11b+LY6G, and CD11b+CD11c myeloid cells in bone marrow had an increase in glioblastoma mice with or without treatment. Importantly, the treated group exhibited no tumor growth or significant small tumors in the brain. Our aim is to study the immune rebalancing of allogeneic macrophage on the glioma-mediated immune resistance in a mouse model of glioblastoma.
John Raymond Smythies
Authors: Paul D McGeoch, VS Ramachandran
Journal: BMJ (2019)

John Raymond Smythies, a British psychiatrist, neuroscientist, and psychedelic pioneer, who spent much of his professional life in the US, died in La Jolla, San Diego, at the age of 96. Smythies was born in Nainital, British India, but as a young boy he was sent to attend school in England. He obtained his medical degree in 1945 from Cambridge, having studied at Christ’s College, with the clinical years spent in London. After two years as a Royal Navy surgeon aboard HMS Porlock Bay in Bermuda, he returned to train as a psychiatrist at St George’s Hospital in London.

It was during this period that he became aware both of the old German literature on the hallucinogenic effects of the peyote cactus derivative mescaline, and also the striking structural similarities between it and a metabolite of adrenalin called adrenochrome. He introduced these ideas to his then senior registrar, Humphrey Osmond, and together they developed and proposed what was the first biochemical theory of schizophrenia—the transmethylation hypothesis. Although ultimately not substantiated, their theory was a paradigm shift in our thinking about psychiatric disease and heralded the modern era of biochemical psychiatry.

The intention back then had been to use psychedelics like mescaline and, …
Carfilzomib Induction with Lenalidomide and Clarithromycin Consolidation and Lenalidomide Maintenance (CarBiRD) for Multiple Myeloma (MM)
Authors: Peter A. Forsberg, Adriana C Rossi, Roger N Pearse, Arthur Perry, Karen Pekle, David Jayabalan, Scott Ely, Morton Coleman, John N. Allan, Ruben Niesvizky, Tomer Mark
Journal: Blood (2016)
Abstract 20667: Age Dependent GSK-3β Hyperactivity Contributes to Atrial Fibrillation in Diabetic Mice in Association With Phosphorylation of the Kv4.2 Subunit of ITo
Authors: Hongwei Jin, Mark Aronovitz, Alfred Albano, Bo Wang, Yali Zhang, Robert Blanton, Mark Link, Hojin Park, Jonas Galper
Journal: Circulation (2017)

Introduction: Diabetes mellitus(DM) is a major age dependent risk factor for atrial fibrillation(AF). The mechanism for age dependent development of AF in DM is poorly understood. Hypothesis: We te...
Endotoxin and (1→3)-β-D-Glucan Contamination in Electronic Cigarette Products Sold in the United States
Authors: Mi-Sun Lee, Joseph G. Allen, David C. Christiani
Journal: Environmental Health Perspectives (2019)

Background: Cigarette smoke contains microbes and microbial toxins, such as endotoxin and (1→3)-β-D-glucan, that may have adverse respiratory effects. To our knowledge, the potential for contamination of electronic cigarette (EC) products sold in the United States has not been investigated. Objectives: We aimed to determine whether popular cartridge and e-liquid EC products were contaminated with endotoxin or glucan and to examine differences according to the type and flavor of products. Methods: We selected 37 cartridges and 38 e-liquid products with the highest nicotine content from the ten top-selling U.S. brands. Flavors were classified into four groups: tobacco, menthol, fruit, and other. Endotoxin and glucan were measured using an endotoxin-specific kinetic turbidimetric assay and a Glucatell® Kinetic Assay (Associates of Cape Cod, Inc.), respectively. Results: Endotoxin concentrations were over the limit of detection (LOD) in 17 of 75 products tested (23%), and glucan concentrations were greater than LOD in 61 of 75 products (81%). After adjusting for brand and flavor, the mean glucan concentration was 3.2 times higher [95% confidence interval (CI): −0.1, 18.4] in cartridge vs. e-liquid samples. After adjusting for brand and type of product, glucan concentrations in tobacco- and menthol-flavored ECs were 10.4 (95% CI: 1.8, 44.9) and 3.5 (95% CI: 0.1, 17.3) times higher than concentrations found in fruit-flavored products. Conclusions: EC products may be contaminated with microbial toxins. Further studies with large representative samples of products are needed to confirm our findings, identify sources and routes of contamination, and evaluate health effects associated with the use of contaminated products. https://doi.org/10.1289/EHP3469
Analysis of -308 tumor necrosis factor (TNF) polymorphism in patients with autoimmune hepatitis types 1 and 2
Authors: Paulo L. Bittencourt, Selma A. Palacios, Eduardo L. R. Cancado, Gilda Porta, Flair José Carrilho, Sandra Drigo, Antônio Atílio Laudanna, Jorge Elias Kalil Filho, Anna C. Goldberg
Journal: Hepatology (1999)
Potential mechanisms of target-independent uptake and toxicity of antibody-drug conjugates
Authors: Prathap Kumar Mahalingaiah, Rita Ciurlionis, Kenneth R. Durbin, Ronnie L. Yeager, Binu K. Philip, Bhupinder Bawa, Srinivasa R. Mantena, Brian P. Enright, Michael J. Liguori, Terry R. Van Vleet
Journal: Pharmacology & Therapeutics (2019)
Abstract 14207: Racial Differences in the Incidence and Outcomes of Heart Failure in Commercially Insured Patients
Authors: Lindsey R Sangaralingham, Nilay D Shah, Veronique L Roger, Shannon M Dunlay
Journal: Circulation (2015)

Background: Epidemiologic studies have demonstrated that the incidence of heart failure varies by race and ethnicity, with the highest incidence occurring in blacks. However, whether these racial and ethnic variations extend to commercially insured populations and whether differences in early outcomes after diagnosis exist requires further exploration. Methods: We utilized administrative claims data from a large U.S. commercial insurance database to retrospectively identify privately insured and Medicare Advantage patients who were diagnosed with heart failure between 2006 and 2014. Published claims-based algorithms were used to identify patients with incident HF and categorize reasons for hospitalization after diagnosis. Results: Among 148,827 patients with incident heart failure (mean age 72.2 years, 51% women), 70% were white, 15% black, 6% Hispanic, 3% Asian and 6% had unknown race/ ethnicity. The incidence of heart failure during the study period was 3.7 per 1000 person-years and was highest among blacks, followed by whites, Hispanics and Asians (9.9, 3.6, 2.5, and 2.0 per 1000 person-years, respectively). In total, 37% of patients were hospitalized at least once in the first year after diagnosis for a total of 93,358 hospitalizations. HF was the most common reason for hospitalization (13% of all hospitalizations), followed by arrhythmia (5%), sepsis (5%), pneumonia (4%), COPD (3%) and acute renal failure (3%). Reasons for hospitalization were similar across racial and ethnic groups. The rate of hospitalizations was highest the first month after diagnosis and then gradually declined. Black patients had the highest rates of hospitalization, while Asians had the lowest (Figure). Conclusions: Even among a commercially insured population that likely have fewer barriers to care, black patients had a higher incidence of HF and higher rates of hospitalization after initial diagnosis compared with other racial and ethnic groups.
The Microbiome and Food Allergy
Authors: Onyinye I. Iweala, Cathryn R. Nagler
Journal: Annual Review of Immunology (2019)

The gut-associated lymphoid tissue (GALT) faces a considerable challenge. It encounters antigens derived from an estimated 10 14 commensal microbes and greater than 30 kg of food proteins yearly. It must distinguish these harmless antigens from potential pathogens and mount the appropriate host immune response. Local and systemic hyporesponsiveness to dietary antigens, classically referred to as oral tolerance, comprises a distinct complement of adaptive cellular and humoral immune responses. It is increasingly evident that a functional epithelial barrier engaged in intimate interplay with innate immune cells and the resident microbiota is critical to establishing and maintaining oral tolerance. Moreover, innate immune cells serve as a bridge between the microbiota, epithelium, and the adaptive immune system, parlaying tonic microbial stimulation into signals critical for mucosal homeostasis. Dysregulation of gut homeostasis and the subsequent disruption of tolerance therefore have clinically significant consequences for the development of food allergy.
Central Amygdala Prepronociceptin-Expressing Neurons Mediate Palatable Food Consumption and Reward
Authors: J. Andrew Hardaway, Lindsay R. Halladay, Christopher M. Mazzone, Dipanwita Pati, Daniel W. Bloodgood, Michelle Kim, Jennifer Jensen, Jeffrey F. DiBerto, Kristen M. Boyt, Ami Shiddapur, Ava Erfani, Olivia J. Hon, Sofia Neira, Christina M. Stanhope, Jonathan A. Sugam, Michael P. Saddoris, Greg Tipton, Zoe McElligott, Thomas C. Jhou, Garret D. Stuber, Michael R. Bruchas, Cynthia M. Bulik, Andrew Holmes, Thomas L. Kash
Journal: Neuron (2019)