tbuckley/cabot-search huggingface dataset:
Prognostic Nutritional Index as a predictive factor of survival in patients with gastric cancer in a Mexican population.
Authors: Marytere Herrera, Arturo Miranda, Fernando Javier Villalobos Peña, IVAN LYRA-GONZALEZ, German Caderillo-Ruiz, Dr. Consuelo Diaz, Erika Ruiz Garcia
Journal: Journal of Clinical Oncology (2019)

85 Background: Gastric cancer is a health problem that is gaining great relevance because despite the multidisciplinary treatment the clinical outcomes are not encouraging; with a diversified prognosis, considering that the results are not only influenced by tumor properties, but also by the patient's condition in an integral way, especially by the nutritional and immunological state. In this study we studied the prognostic nutritionalindex (PNI) as predictive value of survival in patients with gastric cancer. Methods: This is a observational study, 251 patients with diagnosis of gastric adenocarcinoma with locally advanced disease (confirmed by computed tomography (CT)) were analyzed from January 2010 to June 2016. Patients with locally advanced disease confirmed by laparoscopy were taken to radical surgery. Those patients who were taken to laparoscopy and who have been documented metastatic disease, were treated only in a palliative form (chemotherapy, radiotherapy, palliative care). Results: In the analysis of survival through the curves of Kaplan-Meier, and the test log-rank, it was found that patients with a larger tumor size pathological (PT) (3/4/unclassifiable vs 1/2) had an average survival of 25.5 versus 55.5 months (P = &lt; 0.0001). With advanced pathological stages (EP) (III/IV/non-classifiable vs. complete pathological response/I/II) reaching a survival average of 20.4 versus 59.1 months (P = &lt; 0.0001). In the multivariate analysis, it was found that the EP (Hazard radio [HR]: 1.54, confidence interval 95% [CI]: 1.323-1.810, p = &lt; 0.0001) and having received adjuvant chemotherapy (HR: 0332, CI 95%: 0.217-0.508, p = &lt; 0.0001), were independently associated with the overall survival. Conclusions: This study demonstrates that low levels of PNI are associated with advanced diseases and, therefore, worse prognosis, with a tendency towards a decrease in overall survival.
Abstract 15328: Sex Differences in Prescription of Anticoagulation for Atrial Fibrillation
Authors: Kelly T Gleason, Laura Samuel, Cheryl R Dennison Himmelfarb, Harold Lehmann, John William McEvoy, Saman Nazarian
Journal: Circulation (2017)

Introduction: Among individuals with Atrial Fibrillation (Afib), anticoagulation therapies reduce the risk of stroke and death. Women are more likely to experience a stroke than men and this may be...
Abstract P1-15-25: Prognostic factors associated with pathological complete response in early breast cancer patients undergoing neoadjuvant chemotherapy. The importance of Ki-67 and molecular subtype
Authors: BL Rapoport, J Barnard-Tide, T Smit, S Nayler, C-A Benn
Journal: Cancer Research (2019)

Abstract Background: Ki-67 immunohistochemical determination is a widely used biomarker of cell proliferation in patients (pts) undergoing endocrine treatment for breast BC. The role of Ki-67 in pts undergoing neoadjuvant chemotherapy (NAC) for early BC remains controversial. Methods: We analyzed retrospectively data on 137 patients undergoing taxane and/or anthracycline, transtuzumab based NAC. Luminal A was documented in 6 pts, Luminal B in 29 pts, Her-2 positive in 30 pts and triple negative breast cancers (TNBC) in 72 pts. Pathological complete response (pCR) was defined as the complete disappearance of the invasive cancer in the breast and absence of tumor in the axillary lymph nodes examined by axillary clearance. Results: The pCR rate of the entire cohort was 41.6%. At 2 years 92% of pts who attained a pCR were disease free compared to 80% of pts who did not attain a pCR (log rank test p &amp;lt; 0.0147). On univariate analysis factors associated with higher pCR included primary tumor size (T1 68% vs. T2 41% vs. T3 or T4 0%, Chi2=20.05, p&amp;lt;0.00017), nodal disease (N0 49% vs. N1 39% vs. N2 8%, p&amp;lt;0.02948), ER receptor status (negative 59% vs. positive 14%, p&amp;lt;0.00000), PR receptor status (negative 53% vs. positive 17%, p&amp;lt;0.00002), molecular subtype (TNBC 53.4%, Her2=50% and Luminal A + B was 8.5%, p&amp;lt;0.00002), Ki67 (&amp;gt;40=55% vs. 15-39=34% vs. &amp;lt;15=0%, p&amp;lt;0.00060) and Stage (I= 85% vs. IIA=49% vs. IIB=36% vs. III=5%, p&amp;lt;0.00006). Factors not associated with a higher pCR included age, menopausal status, extranodal spread and lympho-vascular invasion. In a logistic regression model Ki-67 as a continuous variable (p&amp;lt;0.01203) and molecular subtype (p&amp;lt;0.02228) retained its significance; while tumor size, stage of disease, nodal status, ER and PR loss significance. Conclusion: Ki67 and molecular subtype (Her-2 positive disease and TNBC) are independent prognostic factors of pCR in pts with early BC undergoing NAC. Citation Format: Rapoport BL, Barnard-Tide J, Smit T, Nayler S, Benn C-A. Prognostic factors associated with pathological complete response in early breast cancer patients undergoing neoadjuvant chemotherapy. The importance of Ki-67 and molecular subtype [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr P1-15-25.
Abstract 11959: The Impact of Genetic Variants Related to LDL-cholesterol on Risk of Ischemic Stroke and Coronary Heart Disease
Authors: Jemma C Hopewell, Traiani Stari, Sarah Parish, Rory Collins, Robert Clarke
Journal: Circulation (2012)

Aims: Statin trials suggest that lowering LDL-C by 1 mmol/l lowers the risk of both ischemic stroke and coronary heart disease (CHD) by about 20%, whilst observational studies have found stronger e...
Rice Genomics: Over the Past Two Decades and into the Future
Authors: Shuhui Song, Dongmei Tian, Zhang Zhang, Songnian Hu, Jun Yu
Journal: Genomics Proteomics & Bioinformatics (2018)

Domestic rice (Oryza sativa L.) is one of the most important cereal crops, feeding a large number of worldwide populations. Along with various high-throughput genome sequencing projects, rice genomics has been making great headway toward direct field applications of basic research advances in understanding the molecular mechanisms of agronomical traits and utilizing diverse germplasm resources. Here, we briefly review its achievements over the past two decades and present the potential for its bright future.
Abstract P285: Potential Direct Medical Cost-Savings Attributable to Physical Activity in Major Disease Categories
Authors: Zachary Rourk, Ivo Abraham, Thomas Olson, Eric Snyder
Journal: Circulation (2018)

Introduction: Physical activity (PA) is known to be effective in treating and preventing many lifestyle diseases including CVD, stroke, depression, type II diabetes, Alzheimer’s disease, as well as breast and colon cancer. To date the direct medical cost-savings of PA as a medical intervention are poorly understood. Hypothesis: We hypothesized that a 10% increase in the proportion of US citizens who meet the minimum weekly exercise requirements of 150 minutes per week would lead to savings in direct medical costs (DMC) and cases prevented, as related to the above diseases. Methods: Population Attributable Risk (PAR) was calculated as PAR= (1+Prf x (RR-1))/(Prf x(RR-1)), where Prf is the percentage of the U.S. population not meeting minimum exercise requirements and RR is the relative risk of disease for sedentary versus physically active individuals. Prf and RR data were retrieved from the most recent and comprehensive meta-analyses and systematic reviews. PAR was calculated for each disease under two conditions; first, Prf was equal to the current percent (9.6%) of the population estimated to achieve the minimum weekly PA requirements. Second, Prf was equal to the initial Prf plus 10 percent (19.6%). For each condition the following were calculated: Attributable DMC=(PAR x DMC), preventable cases=(PAR x Prevalence) and Savings=(Condition 2- Condition 1). Results: The Prevalence, RR, PAR and DMC are provided in Table 1. This table also describes the potential savings in DMC and new cases by improving the Prf by 10%. A 10% increase in US citizens who meet the minimum weekly exercise requirements could lead to a total savings of 10.78 billion USD in DMC and 2.1 million cases prevented related to the studied diseases. Conclusion: A healthcare system directed PA intervention that effectively leads to a 10% increase in US citizens that meet minimum weekly exercise requirements and costs less than 10.78 billion dollars has the potential to be cost-effective, and prevent and treat, millions of cases in the United States.
A germline HLTF mutation in familial MDS induces DNA damage accumulation through impaired PCNA polyubiquitination
Authors: Kensuke Takaoka, Masahito Kawazu, Junji Koya, Akihide Yoshimi, Yosuke Masamoto, Hiroaki Maki, Takashi Toya, Takashi Kobayashi, Yasuhito Nannya, Shunya Arai, Toshihide Ueno, Hironori Ueno, Kenshi Suzuki, Hironori Harada, Atsushi Manabe, Yasuhide Hayashi, Hiroyuki Mano, Mineo Kurokawa
Journal: Leukemia (2019)
What fuses sports fans?
Authors: Dimitris Xygalatas
Journal: Behavioral and Brain Sciences (2018)

Abstract Extreme self-sacrifice in the context of phenomena, such as sports hooliganism, combines aspects of local and extended fusion. How can we best account for such phenomena in the light of the theory presented here, and how can we make a tangible distinction between the two types? I propose ways to explore and operationalize this distinction and the concept of fusion more generally.
Liquid Crystals: Liquid Crystal‐Induced Myoblast Alignment (Adv. Healthcare Mater. 3/2019)
Authors: Daniele Martella, Lorenzo Pattelli, Camilla Matassini, Francesca Ridi, Massimo Bonini, Paolo Paoli, Piero Baglioni, Diederik S. Wiersma, Camilla Parmeggiani
Journal: Advanced Healthcare Materials (2019)

Polarized optical microscope image of C2C12 cells cultured on a liquid crystal (LC)-based scaffold. The same image is recorded without and with a red, yellow, or green filter. In article 1801489, Camilla Parmeggiani and co-workers, LC-based scaffolds are able to reflect the molecular organization inside the polymer in a unidirectional alignment of the global cell culture.
Regional, racial/ethnic, and socioeconomic disparities and treatment outcomes in patients with hepatocellular carcinoma (HCC) in the United States.
Authors: Neehar Parikh, Laura Malahias, Robert S Brown, Roniel Cabrera, Patricia Denise Jones, Charles Landis, Hannah Lee, Parvez Mantry, Edward Mena, Nishant Poddar, K. Rajender Reddy, Roshan Shrestha, Paul Thuluvath, Richard Zink, Amit G. Singal
Journal: Journal of Clinical Oncology (2019)

424 Background: Racial/ethnic (R/E) minorities and patients of low socioeconomic (SE) status are reported to have higher mortality related to HCC than their counterparts. However, prior studies are limited to administrative datasets without annotation for clinical covariates or represent single-center data with limited generalizability. The aim of this analysis was to characterize geographic, R/E, and SE disparities in HCC presentation, treatment, and survival among a representative sample of HCC patients in the US. Methods: TARGET-HCC is an observational, retrospective/prospective study of patients with HCC from academic and community sites. Complete medical records from consented patients are abstracted into a secure database. Multivariable logistic regression with random intercepts for site and Cox proportional hazard models with frailty adjustment were fit with adjustment for age, sex, BMI, liver disease etiology (LDE) and history of alcohol abuse to identify factors associated with early HCC detection, receipt of curative-intent therapy (CIT) and overall survival. Results: 925 patients with HCC (63% non-Hispanic white, 21% black, and 8% Hispanic) were consented from 42 sites in the US (22% Northeast, 27% Southeast, 21% Midwest, 14% South, and 16% West). Median age was 64 years and 76% were men. The most common LDE was hepatitis C (72%), and 72% had Child Pugh A cirrhosis. Most patients were diagnosed with early-stage HCC (72% Barcelona Clinic Liver Cancer 0/A). CIT was the initial therapy in 249 (32%), including 32% of BCLC 0/A. Although early tumor detection and CIT did not differ by region or R/E, there were SE disparities in CIT. Among those with early stage HCC, patients with private insurance [OR = 0.51, 95% CI (0.29, 0.91)] or Medicaid [OR = 0.50, 95% CI (0.25, 0.97)] were significantly less likely to undergo CIT. Overall survival was associated with BCLC stage and type of HCC treatment, with no significant association with region, R/E, or insurance. Conclusions: In this sample of HCC patients, there were no geographic or R/E disparities in early detection, treatment, and survival although SE disparities in administration of CIT were identified and warrant further study.
Improving foundations for future global health practitioners
Authors: Amelia Seifalian, Alex Osborne, Binay Gurung, Emma Norton, Rumneek Hampal, Soham Bandyopadhyay, Jenny Lia Ling Cao, Katarina Hoernke, Ellen Mitchell, Naomi Egbivwie, Georgios Solomou, Dimitrios Karponis, Pippasha Khan, Yogita Joshi
Journal: The Lancet (2019)
Accumulative fusion and the issue of age: Reconciling the model with the data
Authors: Cheskie Rosenzweig, Benjamin C. Ruisch, Chadly Stern
Journal: Behavioral and Brain Sciences (2018)

Abstract We discuss a disconnect between the predictions of Whitehouse's model regarding the accumulative nature of fusion and real-world data regarding the age at which people generally engage in self-sacrifice. We argue that incorporating the link between age and identity development into Whitehouse's theoretical framework is central to understanding when and why people engage in self-sacrifice on behalf of the group.
Abstract 18373: In Vitro Model of Allogenic Cell Transplantation for Conduction Defects - Electrical Coupling Between Rat iPS Cell-Derived Cardiac Cells and Rat Native Cardiac Cells
Authors: Akira Yoshida, Jong-Kook Lee, Shigeru Miyagawa, Yoshiki Sawa, Yasushi Sakata, Issei Komuro
Journal: Circulation (2016)

Introduction: Development of novel therapeutic strategies for bradyarrhythmias has drawn substantial attention. However, clinical applications have not yet been achieved. Whether the transplantatio...
Deciphering Clonal Evolution and Dissemination of Multiple Myeloma Cells In Vivo
Authors: Yujia Shen, Yuji Mishima, Jiantao Shi, Michele Moschetta, Salomon Manier, Aldo M. Roccaro, Francois Mercier, Satoshi Takagi, Yawara Kawano, Shokichi Tsukamoto, Ilyas Sahin, Antonio Sacco, Daisy Huynh, Brianna Berrios, Romanos Pistofidis, Jihye Park, Oksana Zavidij, Sabrin Tahri, John G Doench, David E. Root, Franziska Michor, David T. Scadden, Irene M. Ghobrial
Journal: Blood (2018)
David Oliver: When is it time for older drivers to stop?
Authors: David Oliver
Journal: BMJ (2019)

On 17 January the Duke of Edinburgh was driving his Land Rover when it was in a collision with another car.One of three passengers in the other car was and the duke's car flipped over. 1 The duke, 97, was reportedly left bruised and bewildered.Two days later he was seen driving another Land Rover with no seatbelt and was spoken to by police.
Correcting Non-Transfusion Dependent β-Thalassemia by Utilizing a Combined Therapy that Modulates EPO Activity by Limiting Erythroid Cellular Iron Intake
Authors: Carla Casu, Vania Lo Presti, Mariam Aghajan, Alison Liu, Kevin A Munoz, Emir O'Hara, Garry Neil, Reem Miari, Hagit Domev, Nir Shapir, Shuling Guo, Stefano Rivella
Journal: Blood (2018)
Abstract 20687: Statin Therapy and Risk of Diabetes Mellitus in Aging Patients With Heterozygous Familial Hypercholesterolemia or Familial Combined Hyperlipidemia: A 10-year Follow-up
Authors: Nikolaos Ioakeimidis, John Skoumas, Charalambos Vlachopoulos, Dimitris Terentes-Printzios, Christos Georgakopoulos, Nikitas Skliros, Evangelos Oikonomou, Christina Chrysohoou, Dimitris Tousoulis
Journal: Circulation (2017)

Introduction: Available data suggest that prolonged and intense statin therapy does not seem to increase the risk of type 2 diabetes (DM) in the heterozygous FH (HeFH) population and that high intensity statin therapy used in the familial combined hyperlipidemia (FCH) population is not associated with increased diabetes risk compared with low intensity therapy. Hypothesis: We assessed the incidence of DM in patients with HeFH and FCH treated with statins. Methods: Participants (n=280, mean age 59±5 years; 90 HeFH, 112 FCH and 78 aged-matched participants) were included. Results: The median statin intensity treatment product (statin intensity in arbitrary equivalence units x duration of statin therapy in months) was 119 and 85 for HeFH and FCH patients, respectively, at 10-year follow-up.Kaplan-Meier survival curves for new DM incidence by HeFH, FCH and control groups are illustrated in figure. The incidence of DM was significantly lower in HeFH patients compared with the FCH patients (2 vs 20%) and the re...
Neoadjuvant multimodal treatment of borderline resectable (BRPC) and locally advanced unresectable pancreatic cancer (LAPC) in Mexico.
Authors: Vanessa Rosas Camargo, Edgar Omar Martos Armedáriz, Miriam Heidi Cisneros Cordero, ZULEYMA NIETO GARCIA, Christian Haydeé Flores Balcázar, Mónica Isabel Meneses Medina, Carlos Chan Nuñez, Armando Gamboa Dominguez, Fidel David Huitzil Melendez
Journal: Journal of Clinical Oncology (2019)

454 Background: Pancreatic cancer remains a highly lethal disease. There is no consensus on treatment sequences and chemotherapy (CT) regimen in BRPC and LAPC. Our aim was to describe the multimodal treatment and outcomes in our population. Methods: We retrospectively reviewed medical records of patients (pts) with BRPC/LAPC and histological diagnosis of adenocarcinoma evaluated at Instituto Nacional de Ciencias Médicas y Nutrición from January 2011-December 2016. Clinical and pathological variables at diagnosis and treatment were recorded. Overall survival (OS) was estimated using Kaplan-Meier method and compared by Log-rank test. Results: 69 pts were evaluated, 39% (27) did not receive treatment. We analyze 42 treated pts. BRPC 33%/LAPC 67%. Median age was 58.8 y/o, 54.8% were female. Symptoms at diagnosis: 79% abdominal pain, 76% weight loss, 55% jaundice. ECOG performance status (PS): 0 (17%), 1 (69%) and 2 (14%). Main location was pancreatic head (76%). Median laboratory values: total bilirubin 1.04 mg/dL (0.2-25), albumin 4.1 g/dL (2.4-5.1), CA 19.9 182.8 U/mL (0.8-4028). Laparotomy at diagnosis was performed in 21%. All pts received induction CT (iCT). FOLFIRINOX was the most common regimen (37%), followed by FOLFOX4 (34%). The best overall response with iCT was stable disease (62%), progressive disease was observed in 24%. iCT followed by chemoradiation (CRT) could be delivered to 48% (20/42). Capecitabine-based CRT was preferred (94%). Six pts (14%) underwent surgical resection after multimodal treatment (36% BRPC, 3.5% LAPC), 5 pts achieved R0 resection. The resection rate with single-agent iCT was 0% vs 20% with combination iCT. Median OS was 15.6 months (m): 14.4 m for BRPC and 15.5 m for LAPC. Median OS according iCT: gemcitabine 7.8 m, fluorouracil 13.7 m, FOLFOX4 15.5 m and FOLFIRINOX 24.6 m. Univariate analysis identified ECOG PS (0-1 vs 2, P = 0. 014) and age ( &lt; 59 vs ³59, P = 0.002) as significantly associated with survival. Conclusions: Early administration of combination CT followed by CRT and/o surgical resection in selected pts improves oncological outcomes in pts with BRPC/LAPC. In pts with good PS, iCT with FOLFIRINOX is the preferred regimen given best results.
Ruxolitinib Can Lead to Weight Gain in Patients with Myeloproliferative Neoplasms By Uncoupling Feeding from Central Leptin Signaling Via JAK2/STAT3
Authors: Spencer Krichevsky, Pouneh Kermani, Nicole Molle, Richard T. Silver, Andrew I. Schafer, Ellen K. Ritchie, Joseph Scandura
Journal: Blood (2018)
The ATP-Binding Cassette Gene ABCF1 Functions as an E2 Ubiquitin-Conjugating Enzyme Controlling Macrophage Polarization to Dampen Lethal Septic Shock
Authors: Hitesh Arora, Sara Morgan Wilcox, Laura Alexandra Johnson, Lonna Munro, Brett Alexander Eyford, Cheryl Gurine Pfeifer, Ian Welch, Wilfred Arthur Jefferies
Journal: Immunity (2019)

Sepsis is a bi-phasic inflammatory disease that threatens approximately 30 million lives and claims over 14 million annually, yet little is known regarding the molecular switches and pathways that regulate this disease. Here, we have described ABCF1, an ATP-Binding Cassette (ABC) family member protein, which possesses an E2 ubiquitin enzyme activity, through which it controls the Lipopolysaccharide (LPS)- Toll-like Receptor-4 (TLR4) mediated gram-negative insult by targeting key proteins for K63-polyubiquitination. Ubiquitination by ABCF1 shifts the inflammatory profile from an early phase MyD88-dependent to a late phase TRIF-dependent signaling pathway, thereby regulating TLR4 endocytosis and modulating macrophage polarization from M1 to M2 phase. Physiologically, ABCF1 regulates the shift from the inflammatory phase of sepsis to the endotoxin tolerance phase, and modulates cytokine storm and interferon-β (IFN-β)-dependent production by the immunotherapeutic mediator, SIRT1. Consequently, ABCF1 controls sepsis induced mortality by repressing hypotension-induced renal circulatory dysfunction.
Empowering Multiply Disadvantaged Parents
Authors: Marie B. H. Yap
Journal: JAMA Psychiatry (2019)

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High Complete Response Rates with Pembrolizumab in Combination with Rituximab in Patients with Relapsed Follicular Lymphoma: Results of an Open-Label, Phase II Study
Authors: Loretta Nastoupil, Jason R. Westin, Nathan H. Fowler, Michelle A. Fanale, Felipe Samaniego, Yasuhiro Oki, Ly Dsouza, Chizobam Obi, JingJing Cao, Xiaoyun Cheng, Man Chun John Ma, Wang Zhiqiang, Lei Feng, Shouhao Zhou, R. Eric Davis, Sattva S. Neelapu
Journal: Blood (2017)