tbuckley/cabot-search huggingface dataset:
Psychotherapy, revelation, science, and deep thinking
Authors: T Nadelson
Journal: American Journal of Psychiatry (1996)

Psychodynamic psychotherapy has evolved in the 30 years since John Nemiah was the author's mentor in the endeavor. It has always occupied an epistemologic position somewhere between the scientific standard of physics and the postmodern or poststructuralist view that the search for truth using language is totally futile. However, the awkward niche that psychotherapeutic practice occupies is closer to literary imagination than "hard science." The use of such imagination was presented 25 years ago by John Nemiah in his paper on "Deep Thinking." The poet's "revelation ... not discovered by the rational intellect alone" often imparts in psychotherapeutic practice a compelling urgency toward a previously unrealized choice. Such vision is, however, always located at the periphery of acceptable scientific theory. Psychotherapists persist, often with doubts, because their place is reflective of humanity's awkwardness. Evolution and civilization mutually enfold the human ability to resonate to the anguish of others as well. A species altruism directed toward repair of human problems is coupled with the skills of affectively linked "deep thinking." There is a continuing marginalization of such efforts, which now need to be cared for deeply.
Anti-HCV Agent, Ribavirin, Decreases Events of Bleeding in Hemophilia Patients, Possibly by Elevating the Clotting Activity of Factor VII.
Authors: Koji Yamamoto, Takashi Honda, Satoshi Suzuki, Hidenori Toyoda, Tadashi Matsushita, Tetsuhito Kojima, Hidemi Goto, Junki Takamatsu
Journal: Blood (2005)
Abstract 18886: A Universal Secretory Signature: Analysis of Dynamic Secretomes of Stem Cells Types Uncovers a Common Cytoprotective Paracrine Signature Protecting Cardiac Cells From Reperfusion Induced Stress
Authors: Kshitiz Kshitiz, David D Ellison, Yasir Suhail, Junaid Afzal, Andre Levchenko
Journal: Circulation (2017)

Paracrine signaling by transplanted stem cells can be an important mediator of their therapeutic effects at the sites of acute or persistent injury and inflammation. Understanding the molecular sig...
Abstract 16389: A Propensity-Score Matched Comparison of Cardiovascular Outcomes in Coronary Artery Disease Patients on Beta-Blockers Without Left Ventricular Dysfunction, Hospitalized for Acute Heart Failure
Authors: Abi Khalil Charbel, Kadhim Sulaiman, Nidal Asaad, Khalid AlHabib, Alawi Alsheikh-Ali, Muhammed Jameesh, Mohammed Al-Jarallah, Wael AlMahmeed, Mustafa Ridha, Nooshin Bazargani, Haitham Amin, Ahmed Al-Motarreb, Husam AlFaleh, Prashanth Panduranga, ZIyad Mahfoud, Jassim Al Suwaidi
Journal: Circulation (2018)

Introduction: The prognostic impact of beta-blockers (BB) in coronary artery disease (CAD) is controversial, especially in the post-reperfusion era. Hypothesis: We hypothesized that patients with C...
Blood Lead Levels and Risk of Atherosclerosis in the Carotid Artery: Results from a Swedish Cohort
Authors: Florencia Harari, Lars Barregard, Gerd Östling, Gerd Sallsten, Bo Hedblad, Niklas Forsgard, Yan Borné, Björn Fagerberg, Gunnar Engström
Journal: Environmental Health Perspectives (2019)

Background: Lead exposure has been associated with increased incidence of adverse clinical cardiovascular outcomes. Atherosclerosis has been suggested as one of the underlying mechanisms, and findings from experimental studies support this, but human data are scarce. Objectives: Our objective was to determine the association between environmental lead exposure based on blood lead (B-Pb) concentrations and the prevalence of atherosclerotic plaque in the carotid artery. Methods: We used cross-sectional data from the Malmö Diet and Cancer Study cardiovascular cohort (MDCS-CC; recruitment in 1991–1994) covering 4,172 middle-aged men and women. B-Pb at baseline, measured by inductively coupled plasma mass spectrometry, was used as the exposure biomarker. The presence of atherosclerotic plaque in the carotid artery was determined by B-mode ultrasonography. We used logistic regression to estimate odds ratios (ORs) for prevalence of plaque in the carotid artery according to B-Pb quartiles. Results: The median B-Pb was 25μg/L (range: 1.5–258), and 36% of the cohort had any atherosclerotic plaque. After controlling for confounders and known cardiovascular risk factors, the OR for prevalence of plaque in the highest quartile (Q4) of B-Pb compared with the lowest quartile (Q1) was 1.35 (95% CI: 1.09, 1.66) in the total group, 1.58 (95% CI: 1.20, 2.08) among women, and 1.18 (95% CI: 0.83, 1.69) among men. Among women, associations were limited to those who were postmenopausal [OR for Q4 vs. Q1=1.72 (95% CI: 1.26, 2.34) vs. OR=0.96 (95% CI: 0.49, 1.89 in premenopausal women)]. Associations were weak and nonsignificant in never-smokers [OR for Q4 vs. Q1=1.14 (95% CI: 0.81, 1.61)]. Discussion: Our study shows an association between B-Pb concentrations and occurrence of atherosclerotic plaque in the carotid artery, adding evidence for an underlying pro-atherogenic role of lead in cardiovascular disease. Associations appeared to be limited to postmenopausal (vs. premenopausal) women. https://doi.org/10.1289/EHP5057
IL-36γ drives skin toxicity induced by EGFR/MEK inhibition and commensal Cutibacterium acnes
Authors: Takashi K. Satoh, Mark Mellett, Barbara Meier-Schiesser, Gabriele Fenini, Atsushi Otsuka, Hans-Dietmar Beer, Tamara Rordorf, Julia-Tatjana Maul, Jürg Hafner, Alexander A. Navarini, Emmanuel Contassot, Lars E. French
Journal: Journal of Clinical Investigation (2019)

Epidermal growth factor receptor (EGFR) and MEK inhibitors (EGFRi/MEKi) are beneficial for the treatment of solid cancers but are frequently associated with severe therapy-limiting acneiform skin toxicities. The underlying molecular mechanisms are poorly understood. Using gene expression profiling we identified IL-36γ and IL-8 as candidate drivers of EGFRi/MEKi skin toxicity. We provide molecular and translational evidence that EGFRi/MEKi in concert with the skin commensal bacterium Cutibacterium acnes act synergistically to induce IL-36γ in keratinocytes and subsequently IL-8, leading to cutaneous neutrophilia. IL-36γ expression was the combined result of C. acnes–induced NF-κB activation and EGFRi/MEKi–mediated expression of the transcription factor Krüppel-like factor 4 (KLF4), due to the presence of both NF-κB and KLF4 binding sites in the human IL-36γ gene promoter. EGFRi/MEKi increased KLF4 expression by blockade of the EGFR/MEK/ERK pathway. These results provide an insight into understanding the pathological mechanism of the acneiform skin toxicities induced by EGFRi/MEKi and identify IL-36γ and the transcription factor KLF4 as potential therapeutic targets.
A third of premature deaths in England are linked to social inequality, study finds
Authors: Gareth Iacobucci
Journal: BMJ (2019)

Almost 900 000 deaths in England over the past decade and a half have occurred prematurely because of social inequalities, a study has concluded.1

Researchers at University College London examined records from the UK Office for National Statistics to study 2.5 million premature deaths (defined as those before the age of 75) between 2003 and 2018. They calculated mortality rates for 33 000 neighbourhoods, graded in terms of levels of deprivation.

The study, published in The Lancet Public Health , found that one in three deaths (877 082, 35.6% (95% confidence interval, 35.3 to 35.9)) were attributable to socioeconomic and …
Cardiovascular disease in the aged. Overview of an autopsy series.
Authors: Satoru Matsushita, Makoto Kuroo, Teruyuki Takagi, Eitetsu Hou, Kizuku Kuramoto
Journal: Circulation (1988)

As an overview of cardiovascular disease in the aged, 3657 autopsy cases were analyzed for the frequency and age-wise incidence of cardiovascular disease. The three major categories, ischemic heart disease, valvular heart disease, and aortic aneurysm and dissection were described. 1. The incidence of overall cardiovascular disease increases sharply between the ages of 60 and 75. Prevention and treatment could be effectively directed at this age group. 2. The incidence of organic cardiovascular disease was: myocardial infarction 19.8 percent; valvular disease 10.0 percent; arteriosclerosis obliterans 3.5 percent; aortic aneurysm and dissection 3.3 percent; pericarditis 2.1 percent; cardiomyopathy 1.6 percent; cor pulmonale 1.4 percent; congenital heart disease 0.7 percent; and others 0.8 percent. 3. As coronary sclerosis progresses, death from ischemic heart disease increases; however, 7 out of 10 patients with 3 vessel disease still die of causes other than ischemic heart disease (pneumonia, malignancy etc.). The general management of infection and malignant neoplasms is important in addition to treatment of cardiovascular disease. 4. Except for mitral stenosis, valvular heart disease, the etiology of which is mostly non-rheumatic, increases with advancing age. 5. In aortic aneurysm, the rupture rate is relatively high in the thoracic aorta; however, this may be caused by the successful surgical repair of abdominal aneurysms. An aneurysm below 6 cm in diameter is not absolutely safe from rupture. 6. In aortic dissection, the interval from onset to the death of the patient is often too short to consider surgery.
Chromosome-level genome assembly for giant panda provides novel insights into Carnivora chromosome evolution
Authors: Huizhong Fan, Qi Wu, Fuwen Wei, Fengtang Yang, Bee Ling Ng, Yibo Hu
Journal: Genome biology (2019)

Chromosome evolution is an important driver of speciation and species evolution. Previous studies have detected chromosome rearrangement events among different Carnivora species using chromosome painting strategies. However, few of these studies have focused on chromosome evolution at a nucleotide resolution due to the limited availability of chromosome-level Carnivora genomes. Although the de novo genome assembly of the giant panda is available, current short read-based assemblies are limited to moderately sized scaffolds, making the study of chromosome evolution difficult.Here, we present a chromosome-level giant panda draft genome with a total size of 2.29 Gb. Based on the giant panda genome and published chromosome-level dog and cat genomes, we conduct six large-scale pairwise synteny alignments and identify evolutionary breakpoint regions. Interestingly, gene functional enrichment analysis shows that for all of the three Carnivora genomes, some genes located in evolutionary breakpoint regions are significantly enriched in pathways or terms related to sensory perception of smell. In addition, we find that the sweet receptor gene TAS1R2, which has been proven to be a pseudogene in the cat genome, is located in an evolutionary breakpoint region of the giant panda, suggesting that interchromosomal rearrangement may play a role in the cat TAS1R2 pseudogenization.We show that the combined strategies employed in this study can be used to generate efficient chromosome-level genome assemblies. Moreover, our comparative genomics analyses provide novel insights into Carnivora chromosome evolution, linking chromosome evolution to functional gene evolution.
Prognostic Factors for Outcome of Patients Undergoing Allogeneic HSCT from Unrelated and Related Donors for AML and MDS: A Retrospective Analysis.
Authors: Thorsten Graef, Matthias Vaupel, Roland Fenk, Leilani Ruf, Fabian Zohren, Rainer Haas, Norbert Gattermann, Ulrich Germing, Guido Kobbe
Journal: Blood (2005)
EVIDENCE OF CHLAMYDOPHILA PNEUMONIAE AND HUMAN HERPESVIRUS 8 IN A PATIENT WITH PRIMARY CUTANEOUS ANAPLASTIC LARGE-CELL LYMPHOMA
Authors: Carlo Contini, Elisabetta Caselli, Alessandro Borghi, Silva Seraceni, Martina Maritati, Dario Di Luca, Adolfo Sebastiani, Annarosa Virgili
Journal: Clinical Microbiology and Infection (2013)
Comparison of the efficacy of adjuvant letrozole and anastrozole in hormone-receptor positive postmenopausal breast cancer patients.
Authors: Mehmet Ali Nahit Sendur, Sercan Aksoy, Kadri Altundag
Journal: Journal of Clinical Oncology (2013)

e11554 Background: In the adjuvant hormonal treatment of postmenopausal breast cancer patients, most of the trials have showed the superiority of aromatase inhibitors over tamoxifen. However, there are limited data in the literature comparing the efficacy of aromatase inhibitors in postmenopausal women. Thus, the aim of this study is to compare the efficacy of letrozole and anastrozole in hormone-receptor positive postmenopausal breast cancer patients. Methods: Newly diagnosed breast cancer patients from 2001 to 2012 in our clinic were retrospectively analyzed. A total 566 hormone receptor-positive postmenopausal breast cancer patients were analyzed. The patients were divided into two group; anastrozole group (n=235) and letrozole patients (n=331). Kaplan–Meier survival analysis was carried out for disease free survival (DFS) and overall survival (OS). The log-rank test was used to examine the statistical significance of the differences observed between the groups. Results: The mean age was 59.2±8.5 in anastrozole group, and 60.1±8.4 in letrozole arm (P = 0.19). The mean BMI was 29.4±5.1 kg/m 2 and 29.3±5.3 kg/m 2 of anastrozole and letrozole arm, respectively (P =0.84). The median follow-up time for this analysis was 25.1 months. The histology of the primary tumor and type of surgery was similar and not statistically significant in both groups. Also in both arms the incidence of lymphovascular invasion, perineural invasion, HER2 positivity and histological grade were similar and not statistically significant. There were no apparent differences in baseline nodal status (P = 0.43), tumor size (P = 0.58) and tumor stage (P = 0.15) between two treatment arms. In anastrozole arm DFS rate was 93.7%, 81.3% and 66.0% whereas in letrozole arm DFS rate was 90.6%, 78.7% and 68.5% in the first, third and fifth years respectively. Median OS could not be obtained due to low events in both groups. Three year survival rate in anastrozole group was 98.8%, whereas in letrozole arm was 96.7% (P=0.84). Conclusions: In this retrospective study, the efficacy of letrozole and anastrozole was similar in hormone-receptor positive postmenopausal breast cancer patients.
Cognitive symptoms of Alzheimer’s disease: clinical management and prevention
Authors: Elizabeth Joe, John M Ringman
Journal: BMJ (2019)

ABSTRACT Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by the accumulation of amyloid β in the form of extracellular plaques and by intracellular neurofibrillary tangles, with eventual neurodegeneration and dementia. There is currently no disease-modifying treatment though several symptomatic medications exist with modest benefit on cognition. Acetylcholinesterase inhibitors have a consistent benefit across all stages of dementia; their benefit in mild cognitive impairment and prodromal AD is unproven. Memantine has a smaller benefit on cognition overall which is limited to the moderate to severe stages, and the combination of a cholinesterase inhibitor and memantine may have additional efficacy. Evidence for the efficacy of vitamin E supplementation and medical foods is weak but might be considered in the context of cost, availability, and safety in individual patients. Apparently promising disease-modifying interventions, mostly addressing the amyloid cascade hypothesis of AD, have recently failed to demonstrate efficacy so novel approaches must be considered.
Upregulation of XAF1 by 5-Aza-2′-Deoxycytidine Sensitizes Busulfan-Resistant Human CML Cells; Implications for Pretransplant Conditioning Therapy in Myeloid Leukemia
Authors: Benigno C. Valdez, Yang Li, David Murray, Richard E. Champlin, Borje S. Andersson
Journal: Blood (2008)
Biomaterials for stem cell engineering and biomanufacturing
Authors: Yibo Xu, Chuanxin Chen, Peter B. Hellwarth, Xiaoping Bao
Journal: Bioactive Materials (2019)

Recent years have witnessed the expansion of tissue failures and diseases. The uprising of regenerative medicine converges the sight onto stem cell-biomaterial based therapy. Tissue engineering and regenerative medicine proposes the strategy of constructing spatially, mechanically, chemically and biologically designed biomaterials for stem cells to grow and differentiate. Therefore, this paper summarized the basic properties of embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs) and adult stem cells. The properties of frequently used biomaterials were also described in terms of natural and synthetic origins. Particularly, the combination of stem cells and biomaterials for tissue repair applications was reviewed in terms of nervous, cardiovascular, pancreatic, hematopoietic and musculoskeletal system. Finally, stem-cell-related biomanufacturing was envisioned and the novel biofabrication technologies were discussed, enlightening a promising route for the future advancement of large-scale stem cell-biomaterial based therapeutic manufacturing.
Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study
Authors: Katrina M Moore, Jennifer Nicholas, Murray Grossman, Corey T McMillan, David J Irwin, Lauren Massimo, Vivianna M Van Deerlin, Jason D Warren, Nick C Fox, Martin N Rossor, Simon Mead, Martina Bocchetta, Bradley F Boeve, David S Knopman, Neill R Graff-Radford, Leah K Forsberg, Rosa Rademakers, Zbigniew K Wszolek, John C van Swieten, Lize C Jiskoot, Lieke H Meeter, Elise GP Dopper, Janne M Papma, Julie S Snowden, Jennifer Saxon, Matthew Jones, Stuart Pickering-Brown, Isabelle Le Ber, Agnès Camuzat, Alexis Brice, Paola Caroppo, Roberta Ghidoni, Michela Pievani, Luisa Benussi, Giuliano Binetti, Bradford C Dickerson, Diane Lucente, Samantha Krivensky, Caroline Graff, Linn Öijerstedt, Marie Fallström, Håkan Thonberg, Nupur Ghoshal, John C Morris, Barbara Borroni, Alberto Benussi, Alessandro Padovani, Daniela Galimberti, Elio Scarpini, Giorgio G Fumagalli, Ian R Mackenzie, Ging-Yuek R Hsiung, Pheth Sengdy, Adam L Boxer, Howie Rosen, Joanne B Taylor, Matthis Synofzik, Carlo Wilke, Patricia Sulzer, John R Hodges, Glenda Halliday, John Kwok, Raquel Sanchez-Valle, Albert Lladó, Sergi Borrego-Ecija, Isabel Santana, Maria Rosário Almeida, Miguel Tábuas-Pereira, Fermin Moreno, Myriam Barandiaran, Begoña Indakoetxea, Johannes Levin, Adrian Danek, James B Rowe, Thomas E Cope, Markus Otto, Sarah Anderl-Straub, Alexandre de Mendonça, Carolina Maruta, Mario Masellis, Sandra E Black, Philippe Couratier, Geraldine Lautrette, Edward D Huey, Sandro Sorbi, Benedetta Nacmias, Robert Laforce, Marie-Pier L Tremblay, Rik Vandenberghe, Philip Van Damme, Emily J Rogalski, Sandra Weintraub, Alexander Gerhard, Chiadi U Onyike, Simon Ducharme, Sokratis G Papageorgiou, Adeline Su Lyn Ng, Amy Brodtmann, Elizabeth Finger, Rita Guerreiro, Jose Bras, Jonathan D Rohrer, Carolin Heller, Rhian S Convery, Ione OC Woollacott, Rachelle M Shafei, Jonathan Graff-Radford, David T Jones, Christina M Dheel, Rodolfo Savica, Maria I Lapid, Matt Baker, Julie A Fields, Ralitza Gavrilova, Kimiko Domoto-Reilly, Jackie M Poos, Emma L Van der Ende, Jessica L Panman, Laura Donker Kaat, Harro Seelaar, Anna Richardson, Giovanni Frisoni, Anna Mega, Silvia Fostinelli, Huei-Hsin Chiang, Antonella Alberici, Andrea Arighi, Chiara Fenoglio, Hilary Heuer, Bruce Miller, Anna Karydas, Jamie Fong, Maria João Leitão, Beatriz Santiago, Diana Duro, Carlos Ferreira, Alazne Gabilondo, Maria De Arriba, Mikel Tainta, Miren Zulaica, Catarina Ferreira, Elisa Semler, Albert Ludolph, Bernhard Landwehrmeyer, Alexander E Volk, Gabriel Miltenberger, Ana Verdelho, Sónia Afonso, Maria Carmela Tartaglia, Morris Freedman, Ekaterina Rogaeva, Camilla Ferrari, Irene Piaceri, Valentina Bessi, Gemma Lombardi, Frédéric St-Onge, Marie-Claire Doré, Rose Bruffaerts, Mathieu Vandenbulcke, Jan Van den Stock, M Marsel Mesulam, Eileen Bigio, Christos Koros, John Papatriantafyllou, Christos Kroupis, Leonidas Stefanis, Christien Shoesmith, Erik Robertson, Giovanni Coppola, Eliana Marisa Da Silva Ramos, Daniel Geschwind
Journal: The Lancet Neurology (2019)
Association Between e-Cigarette Use and Depression in the Behavioral Risk Factor Surveillance System, 2016-2017
Authors: Olufunmilayo H. Obisesan, Mohammadhassan Mirbolouk, Albert D. Osei, Olusola A. Orimoloye, S. M. Iftekhar Uddin, Omar Dzaye, Omar El Shahawy, Mahmoud Al Rifai, Aruni Bhatnagar, Andrew Stokes, Emelia J. Benjamin, Andrew P. DeFilippis, Michael J. Blaha
Journal: JAMA Network Open (2019)

<h3>Importance</h3> The prevalence of the use of electronic cigarettes (e-cigarettes) in the United States has grown rapidly since their introduction to the market more than a decade ago. While several studies have demonstrated an association between combustible cigarette smoking and depression, the association between e-cigarette use and depression has not been thoroughly studied. <h3>Objective</h3> To examine the association between e-cigarette use and depression in a nationally representative sample of the adult population in the United States. <h3>Design, Setting, and Participants</h3> Cross-sectional study of the Behavioral Risk Factor Surveillance System database, 2016 to 2017. The Behavioral Risk Factor Surveillance System is the largest national telephone-based survey of randomly sampled adults in the United States. A total of 892 394 participants with information on e-cigarette use and depression were included. Data analysis was conducted in May 2019. <h3>Exposures</h3> Electronic cigarette use status defined by self-report as never, former, or current use. <h3>Main Outcomes and Measures</h3> Self-reported history of a clinical diagnosis of depression. <h3>Results</h3> Of the 892 394 participants (414 326 [29.0%] aged ≥60 years; 502 448 [51.3%] women), there were 28 736 (4.4%) current e-cigarette users, of whom 13 071 (62.1%) were aged between 18 and 39 years. Compared with never e-cigarette users, current e-cigarette users were more likely to be single, male, younger than 40 years, and current combustible cigarette smokers (single, 120 797 [24.3%] vs 10 517 [48.4%]; men, 318 970 [46.6%] vs 14 962 [60.1%]; aged 18-39 years, 129 085 [32.2%] vs 13 071 [62.1%]; current combustible cigarette use, 217 895 [7.9%] vs 8823 [51.8%]). In multivariable adjusted models, former e-cigarette users had 1.60-fold (95% CI, 1.54-1.67) higher odds of reporting a history of clinical diagnosis of depression than never users, whereas current e-cigarette users had 2.10 (95% CI, 1.98-2.23) times higher odds. Additionally, higher odds of reporting depression were observed with increased frequency of use among current e-cigarette users compared with never users (daily use: odds ratio, 2.39; 95% CI, 2.19-2.61; occasional use: odds ratio, 1.96; 95% CI, 1.82-2.10). Similar results were seen in subgroup analyses by sex, race/ethnicity, smoking status, and student status. <h3>Conclusions and Relevance</h3> This study found a significant cross-sectional association between e-cigarette use and depression, which highlights the need for prospective studies analyzing the longitudinal risk of depression with e-cigarette use. If confirmed by other study designs, the potential mental health consequences may have regulatory implications for novel tobacco products.