tbuckley/cabot-search huggingface dataset:
Response to: ‘Increasing the threshold for patient global assessment in defining remission may have a different impact in patients with early and established rheumatoid arthritis’ by Bugatti<i>et al</i>
Authors: Paul Studenic, David T Felson, Maarten de Wit, Josef S Smolen, Daniel Aletaha
Journal: Annals of the Rheumatic Diseases (2020)

We thank Bugatti et al for their interest in our paper and for sharing their results on applying a 2 cm cut-off for the patient global assessment (PGA) criterion of the Boolean remission criteria for rheumatoid arthritis (RA) within the setting of a real-world database,1 which confirm the data presented in our recent report based on a clinical trial population.2 An appropriate definition for remission is of utmost relevance to prevent structural progression or functional deterioration, regardless of the treatment regimen used; in fact, such a definition is clearly needed in clinical practice, where today a significant proportion of patients is able to attain very good control of disease activity.3–6 The currently used provisional ACR/EULAR remission should be revisited to no longer be provisional.7 Ideally, the definition of remission should be applicable to all …
OUTCOMES OF BILIO-PANCREATIC EUS IN PATIENTS WITH SURGICALLY ALTERED UPPER GI ANATOMY: A RETROSPECTIVE MULTICENTER STUDY
Authors: SF Crinò, L Brozzi, MC Petrone, JW Poley, S Carrara, L Barresi, C Fabbri, M Rimbas, CD Angelis, PG Arcidiacono, M Signoretti, L Lamonaca, I Barbuscio, C Binda, A Gheorghe, S Rizza, A Gabbrielli
Journal: Endoscopy (2020)

Aims Little is known about outcomes of bilio-pancreatic endosonography (EUS) in patients with surgically altered upper gastrointestinal (GI) anatomy. We aimed to assess the performance of EUS, the rate of procedural success and of EUS-related adverse events (AEs), according to post-surgical anatomies.
Outcomes of Gallbladder Polyps and Their Association With Gallbladder Cancer in a 20-Year Cohort
Authors: Jean-Luc Szpakowski, Lue-Yen Tucker
Journal: JAMA Network Open (2020)

Gallbladder polyps (GP) are found in more than 4% of adult abdominal ultrasonographs. Their growth pattern and association with gallbladder cancer (GBC) are poorly defined.To determine the growth pattern of GPs and their association with GBC.This cohort study included 622 227 adult members (ie, aged 18 years or older) of Kaiser Permanente Northern California, an integrated health care delivery system, enrolled between January 1, 1995, and December 31, 2014. The GBC cohort comprised a total of 365 adults with GBC and prior ultrasonography, and the GP cohort comprised 35 970 adults with GPs present on ultrasonography. Data analysis was performed from March 2016 to November 2019.Gallbladder polyps (quantitative size, <6 mm, 6 to <10 mm, and ≥10 mm or qualitative size [ie, tiny, small, moderate, and large]).For the GBC cohort, proportion of patients with GBC with polyps identified on preceding ultrasonograph. For the GP cohort, rates of GBC among those with polyps according to size and rate of GP growth of at least 2 mm over time.The GBC cohort comprised 365 individuals (267 [73.1%] women; 173 [47.4%] white patients; median [interquartile range] age, 71 [61-79] years). After excluding 14 patients who did not have evaluation of polyp size, the final GP cohort comprised 35 856 adults, with 18 645 (52.0%) women, a median (interquartile range) age 50 (40-60) years, and 15 573 (43.3%) white patients. Gallbladder polyps were found in 22 patients (6.0%) in the GBC cohort and in 35 870 of 622 227 adults (5.8%) who underwent abdominal ultrasonography. Of these, 19 (0.053%) were diagnosed with GBC, similar to those without GP (316 of 586 357 [0.054%]). The unadjusted GBC rate per 100 000 person-years was 11.3 (95% CI, 6.2-16.3) overall and increased with polyp size, from 1.3 (95% CI, 0-4.0) with initial size of less than 6 mm (n = 17 531) to 128.2 (95% CI, 39.4-217.0) with initial size of 10 mm or larger (n = 2055). In those observed for at least 1 year, the rate was 3.6 (95% CI, 0.7-6.5) per 100 000 person-years. In 6359 patients with evaluable follow-up, unadjusted cumulative probabilities of polyp growth of at least 2 mm at 10 years were 66.2% (95% CI, 62.3%-70.0%) in polyps initially less than 6 mm and 52.9% (95% CI, 47.1%-59.0%) in polyps initially 6 mm to less than 10 mm.In this study, GBC rates were low and similar among patients with and without GPs. Growth of 2 mm or more appeared to be part of GP natural history. The results call into question the strategy of proactively following GP to detect GBC.
ENDOSCOPIC TREATMENT FOR ZENKER´S DIVERTICULUM WITH THE STAG BEETLE KNIFE (SB KNIFE) – PRELIMINARY RESULTS FROM A SINGLE-CENTER EXPERIENCE
Authors: M Devani, R Reati, C Bezzio, S Saibeni, B Omazzi, I Arena, G De Nucci, CD Corte, G Manes
Journal: Endoscopy (2020)

Aims Flexible endoscopic treatment of symptomatic Zenker´s diverticulum (ZD) is an established treatment option. We report our experience with a scissor-shaped, rotating device with two insulated monopolar blades (SB knife) designed primarily for endoscopic submucosal dissection. Little data are reported about its use for Zenker diverticulum.
Landmark survival analysis and impact of anatomic site of origin in prospective clinical trials of biliary tract cancer
Authors: Mairéad Geraldine McNamara, Andre Lopes, Harpreet Wasan, David Malka, David Goldstein, Jenny Shannon, Takuji Okusaka, Jennifer J. Knox, Anna Dorothea Wagner, Thierry André, David Cunningham, Markus Moehler, Lars Henrik Jensen, Dieter Koeberle, Tanios Bekaii-Saab, John Bridgewater, Juan W. Valle
Journal: Journal of Hepatology (2020)
Covid-19: Trump fumes as adviser speaks out against lifting of US lockdowns
Authors: Owen Dyer
Journal: BMJ (2020)

Tension between the Trump administration and its public health officials burst into the open this week, as President Donald Trump openly criticised his top infectious disease specialist, Anthony Fauci, for testifying in Congress against the reopening of states that have not met the administration’s published criteria for ending their lockdowns.1

Dozens of mostly Republican controlled states are lifting restrictions despite failing grades on metrics such as new daily infections and percentage of positive test results. As the US passes 85 000 reported deaths, the president who published those criteria a month ago is now openly supportive of states that defy them.

But the threat has not diminished, Fauci warned the Senate, after Trump blocked him from testifying before the US House. “Needless suffering and death” will ensue if lockdowns are lifted prematurely, he said. The virtual hearing spoke volumes about the readiness of some workplaces to reopen, with both Fauci and the committee chairman, Senator Lamar Alexander, currently self-isolating after potential exposures.

Republican senator Rand Paul—who drew criticism last month for swimming in the Senate …
SAFETY AND EFFECTIVENESS OF ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY IN PATIENTS OLDER THAN 90 YEARS
Authors: TN Kim, MC Kim, SB Kim, KH Kim, KO Kim, SH Lee, BI Jang
Journal: Endoscopy (2020)

Aims ERCP is an effective diagnostic and therapeutic procedure in pancreaticcobiliary diseases. Because the risk of complications increases with aging, more attention should be paid during ERCP in elderly patients. This study was aimed to evaluate the safety and effectiveness of ERCP in patients older than 90 years.
Gestational trophoblastic disease
Authors: H. Fox
Journal: BMJ (1997)

The term gestational trophoblastic disease includes hydatidiform moles, invasive hydatidiform moles, and choriocarcinoma. However, many gynaecologists and oncologists seem to consider that these conditions represent a neoplastic spectrum, with moles at the benign end, choriocarcinoma at the malignant extreme, and invasive hydatidiform moles being equivalent to a neoplasm of borderline malignancy. I would argue that there is nothing to suggest that a hydatidiform mole of any type is a form of neoplasia. Both partial and complete hydatidiform moles are chromosomally abnormal pregnancies: the complete moles are androgenetic pregnancies, all their nuclear DNA being paternally derived,1 and partial hydatidiform moles are triploid gestations,2 in which the extra chromosomal load is of paternal origin.3

At first sight invasive hydatidiform moles seem better candidates for being classed as neoplasms because they penetrate into or through the myometrium and invade the uterine vasculature, allowing molar tissue to spread through the blood stream to extrauterine sites. However, normal …
Procleave: Predicting Protease-Specific Substrate Cleavage Sites by Combining Sequence and Structural Information
Authors: Fuyi Li, Andre Leier, Quanzhong Liu, Yanan Wang, Dongxu Xiang, Tatsuya Akutsu, Geoffrey I. Webb, A. Ian Smith, Tatiana Marquez-Lago, Jian Li, Jiangning Song
Journal: Genomics Proteomics & Bioinformatics (2020)

Abstract Proteases are enzymes that cleave and hydrolyse the peptide bonds between two specific amino acid residues of target substrate proteins. Protease-controlled proteolysis plays a key role in the degradation and recycling of proteins, which is essential for various physiological processes. Thus, solving the substrate identification problem will have important implications for the precise understanding of functions and physiological roles of proteases, as well as for therapeutic target identification and pharmaceutical applicability. Consequently, there is a great demand for bioinformatics methods that can predict novel substrate cleavage events with high accuracy by utilizing both sequence and structural information. In this study, we present Procleave, a novel bioinformatics approach for predicting protease-specific substrates and specific cleavage sites by taking into account both their sequence and 3D structural information. Structural features of known cleavage sites were represented by discrete values using a LOWESS data-smoothing optimization method, which turned out to be critical for the performance of Procleave. The optimal approximations of all structural parameter values were encoded in a conditional random field (CRF) computational framework, alongside sequence and chemical group-based features. Here, we demonstrate the outstanding performance of Procleave through extensive benchmarking and independent tests. Procleave is capable of correctly identifying most cleavage sites in the case study. Importantly, when applied to the human structural proteome encompassing 17,628 protein structures, Procleave suggests a number of potential novel target substrates and their corresponding cleavage sites of different proteases. Procleave is implemented as a webserver and is freely accessible at http://procleave.erc.monash.edu/.
Multiple-centre clinical evaluation of an ultrafast single-tube assay for SARS-CoV-2 RNA
Authors: J. Wang, K. Cai, X. He, X. Shen, J. Wang, J. Liu, J. Xu, F. Qiu, W. Lei, L. Cui, Y. Ge, T. Wu, Y. Zhang, H. Yan, Y. Chen, J. Yu, X. Ma, H. Shi, R. Zhang, X. Li, Y. Gao, P. Niu, W. Tan, G. Wu, Y. Jiang, W. Xu, X. Ma
Journal: Clinical Microbiology and Infection (2020)
Dose optimisation of first-line tuberculosis drugs using therapeutic drug monitoring in saliva: feasible for rifampicin, not for isoniazid
Authors: Simone H.J. van den Elsen, Onno W. Akkerman, Mireille Wessels, Erwin M. Jongedijk, Samiksha Ghimire, Tjip S. van der Werf, Mathieu S. Bolhuis, Daan J. Touw, Jan-Willem C. Alffenaar
Journal: European Respiratory Journal (2020)

<b>Therapeutic drug monitoring using saliva samples is feasible for rifampicin, despite low penetration, but is not feasible for isoniazid, which showed inexplicable highly variable saliva/serum concentration ratios</b>https://bit.ly/2yAS2Jc
Zeb1 represses TCR signaling, promotes the proliferation of T cell progenitors and is essential for NK1.1+ T cell development
Authors: Jiang Zhang, Mélanie Wencker, Quentin Marliac, Aurore Berton, Uzma Hasan, Raphaël Schneider, Daphné Laubreton, Dylan E. Cherrier, Anne-Laure Mathieu, Amaury Rey, Wenzheng Jiang, Julie Caramel, Laurent Genestier, Antoine Marçais, Jacqueline Marvel, Yad Ghavi-Helm, Thierry Walzer
Journal: Cellular and Molecular Immunology (2020)
Low ADC in CNS Lymphoma
Authors: Nadya Pyatigorskaya, Damien Galanaud, Didier Dormont, Carole Soussain, Aurelie Kas
Journal: Clinical Nuclear Medicine (2020)

Abstract Patients with primary central nervous system lymphomas (PCNSLs) present with nonspecific clinical symptoms, which makes correct imaging evaluation essential for diagnostic and therapeutic management. In this work, we examined an 81-year-old man with recently discovered PCNSL using 18 F-FDG PET/MRI, and we were able to differentiate between 2 lesions—PCNSL lymphoma extension and a recent ischemia. Our work shows that ischemia should be considered as a differential diagnosis for lymphoma progression. Although 18 F-FDG PET or MRI alone cannot always give unambiguous solution, PET/MRI can greatly improve the diagnosis accuracy and help decide on the appropriate patient management.
National Assessment of Surprise Coverage Gaps Provided to Simulated Patients Seeking Emergency Care
Authors: Vivek Parwani, Andrew Ulrich, Craig Rothenberg, Jeremiah Kinsman, Matthew Duhaime, Melissa Thomas, Arjun Venkatesh
Journal: JAMA Network Open (2020)

This cross-sectional study evaluates surprise coverage gaps in health insurance by using secret shopper phone call methods to assess whether hospital billing staff in the US are able to answer a set of patient questions about insurance coverage.
IS COLORECTAL POLYP CHARACTERIZATION BETTER WITH PHOTOGRAPHS OR VIDEO CLIPS? RANDOMISED PROSPECTIVE STUDY WITH TRAINEES, SENIOR GASTROENTEROLOGISTS (GE) AND EXPERTS
Authors: L Héroin, J Jacques, O Gronier, J-M Reimund, D Sautereau, S Chaussade, M Pioche
Journal: Endoscopy (2020)

Aims Accurate real-time characterization of colorectal polyps during colonoscopy is important as it will allow the most appropriate treatment to be chosen. No study has ever shown if videoclips or photographs are better for characterization.
HBV‐Induced Increased N6 Methyladenosine Modification of PTEN RNA Affects Innate Immunity and Contributes to HCC
Authors: Geon‐Woo Kim, Hasan Imam, Mohsin Khan, Saiful Anam Mir, Seong‐Jun Kim, Seung Kew Yoon, Wonhee Hur, Aleem Siddiqui
Journal: Hepatology (2020)

Background and Aims Epitranscriptomic modification of RNA has emerged as the most prevalent form of regulation of gene expression that affects development, differentiation, metabolism, viral infections, and most notably cancer. We have previously shown that hepatitis B virus (HBV) transcripts are modified by N6 methyladenosine (m 6 A) addition. HBV also affects m 6 A modification of several host RNAs, including phosphatase and tensin homolog (PTEN), a well‐known tumor suppressor. PTEN plays a critical role in antiviral innate immunity and the development of hepatocellular carcinoma (HCC). Reports have shown that PTEN controlled interferon regulatory factor 3 (IRF‐3) nuclear localization by negative phosphorylation of IRF‐3 at Ser97, and PTEN reduced carcinogenesis by inhibiting the phosphatidylinositol‐3‐kinase (PI3K)/AKT pathway. Approach and Results Here, we show that HBV significantly increases the m 6 A modification of PTEN RNA, which contributes to its instability with a corresponding decrease in PTEN protein levels. This is reversed in cells in which the expression of m 6 A methyltransferases is silenced. PTEN expression directly increases activated IRF‐3 nuclear import and subsequent interferon synthesis. In the absence of PTEN, IRF‐3 dephosphorylation at the Ser97 site is decreased and interferon synthesis is crippled. In chronic HBV patient biopsy samples, m 6 A‐modified PTEN mRNA levels were uniformly up‐regulated with a concomitant decrease of PTEN mRNA levels. HBV gene expression also activated the PI3K/AKT pathway by regulating PTEN mRNA stability in HCC cell lines. Conclusions The m 6 A epitranscriptomic regulation of PTEN by HBV affects innate immunity by inhibiting IRF‐3 nuclear import and the development of HCC by activating the PI3K/AKT pathway. Our studies collectively provide new insights into the mechanisms of HBV‐directed immune evasion and HBV‐associated hepatocarcinogenesis through m 6 A modification of the host PTEN mRNAs.
SEVERE HEMOBILIA DUE TO ARTERIO-BILIARY FISTULA. DIAGNOSIS AND TREATMENT BY ENDOSCOPIC ULTRASOUND
Authors: M Bozhychko, LM Prado, SB Maxia, C Mangas Sanjuan, J Martinez Sempere, LC Catalá, F Ruíz Gómez, JA Casellas Valdé, JRA Tormo
Journal: Endoscopy (2020)

75-year-old man with locally advanced cholangiocarcinoma. Uncovered self-expandable metal stent for biliary drainage was placed by ERCP. The patient was admitted to the hospital because of hematemesis. ERCP demonstrated direct visualization of oozing blood through the papilla. The patient presented hemodynamic instability following balloon catheter removal. Fully covered self-expandable metal stent (10x60 mm) was delivered blindly. EUS revealed anomalous artery adjacent to the stent with active bleeding into the common bile duct. Embolization of the anomalous blood vessel was attempted using 22-gauge needle and five 0.0018-inch coils (Tornado Embolizations Coils). Bleeding cessation and hemodynamic stabilization were achieved after the procedure.
Defining the directionality and quality of influenza virus-specific CD8(+) T cell cross-reactivity in individuals infected with hepatitis C virus (vol 118, pg 1143, 2008)
Authors: V Kasprowicz, S M Ward, A Turner, A Grammatikos, B E Nolan, L Lewis-Ximenez, C Sharp, J Woodruff, V M Fleming, S Sims, B D Walker, A K Sewell, G M Lauer, P Klenerman
Journal: Journal of Clinical Investigation (2011)
UNDERWATER EN-BLOC EMR FOR NON-GRANULAR LST PSEUDO-DEPRESSED
Authors: H Uchima, JAC Hernandez, I Marin, EN Caballero, I Iborra, A Clos, D Luna, F Cañete, E Domenech, VM De Vega
Journal: Endoscopy (2020)

Pseudodepressed NG LST have to be resected en bloc due to an elevated risk of deep submucosal invasion. We present the case of a 85 years old patient referred for endoscopic resection of a pseudodepressed NG LST of more than half of the circular wall of the ascending colon with previous biopsy showing high-grade dysplasia, and no endoscopic signs of deep submucosal invasion.
A PROSPECTIVE EVALUATION OF THE GOTHENBURG INTESTINAL TRANSPLANT ENDOSCOPY SCORE
Authors: J Varkey, S Yamamoto, G Herlenius, R Sadik, M Oltean
Journal: Endoscopy (2020)

Aims Intestinal transplantation is a procedure aimed to reverse the life-threatening complications seen in patients with intestinal failure. However, the major factor that influences long-term survival and hinders a firm establishment of this procedure is the occurrence of rejection. Nevertheless, a grading system for its severity is still lacking. Therefore Gothenburg Intestinal Transplant Endoscopy Score (GITES) was developed by our team. GITES is a novel, five-stage score aiming to describe and categorize the endoscopic findings after intestinal transplantation. In theory, this system could result in a more objective evaluation of the visual findings and subsequently a faster diagnosis of rejection.
복수를 동반한 간경변증 환자에서 임의뇨 Na/K 비의 진단적 유용성: 예비연구
Authors: 박재은 ( Jae Eun Park ), 이창형 ( Chang Hyeong Lee ), 김병석 ( Byung Seok Kim ), 신임희 ( Im Hee Shin )
Journal: Clinical and Molecular Hepatology (2010)

목적: 복수를 동반한 간경변증의 치료는 식이염분 섭취 제한과 이뇨제 치료로서 24시간 소변 나트륨 배설량이 78mmol 이상일 때 복수가 호전되는 것에 근거를 두고 있으나 24시간 소변 나트륨 배설량의 채집은 귀찮고 성가신 일로 느껴지게 하는 경우가 많다. 이에 저자들은 오전 1회 이뇨제를 투여하는 환자에서 오전 및 오후에 각각 실시한 임의뇨Na/K 비가 24시간 소변 나트륨 배설량을 정확하게 반영하는지와 이뇨제 반응 평가를 위한 임의뇨Na/K 비의 분포 및 확정값을 알아보고자 본 연구를 시행하였다. 대상 및 방법: 2007년 10월부터 2008년 3월까지 간경변증성 복수를 치료하기 위하여 입원 중 에 이뇨제를 5일 이상 투여한 42명의 남자 환자를 대상으로 하였다. 모든 환자는 오전 8 시에 이뇨제를 투약하였으며, 24시간 소변 수집 중이뇨제 투약 2∼4시간 후와 7∼9시간 후(오전 10∼12시 및 오후 3∼5시)에 하루 두 차례씩 임의뇨를 5 mL씩 채취하였다. 임의뇨 Na/K 비의 ROC 곡선 분석 및 ROC 곡선하면적을 구하여 측정 시기에 따른 검사의 일치도 및 신뢰도를 구하였으며 Na/K 비의 분포와 적절한 확정값을 산출하였다. 결과: 총 42명의 환자 중 24시간 소변 크레아티닌배설량이 15 mEq/kg 이상인 환자 40명에 대해 분석하였다. 24시간 소변량과 24시간 소변 나트륨 배설량의 평균은 1,722.5±915.3(범위 500∼3,500mL)과 107.9±91.2mmol(범위 3∼366mmol)였다. 오전 및 오후의 임의뇨 Na/K 비의 평균은 각각 3.4±3.6와 3.9±4.6이었다. 24시간 소변 나트륨 배설량이 78 mmol 이상에 대한 오전 및 오후 임의뇨 Na/K 비의 ROC 곡선 분석 결과 ROC 곡선하면적은 0.861(95% CI, 0.715∼0.950) 및 0.929 (95% CI, 0.802∼0.986)였다(P=0.0001). 측정 시기에 따른 오전 및 오후의 임의뇨 Na/K 비의 ROC 곡선하면적차이는 0.0682(95% CI, -0.161∼0.153)로 통계적 유의성이 없었다(P=0.113). 따라서, 오전과 오후 임의뇨 검사의 ROC 곡선의 차이가 관찰되지 않고 낮 시간 동안 채취한 임의뇨 Na/K 비가 1.25∼1.45사이일 때 민감도와 특이도가 가장 뛰어난 확정값을 가지므로 낮 시간 언제라도 측정한 임의뇨Na/K 비가 1.25 이상일 때 24시간 소변 나트륨 배설량이 78mmo 이상임을 예측할 수 있었다. 결론: 낮시간 언제라도 시행한 임의뇨 Na/K 비가 1.25 이상일 때 24시간 소변 나트륨 배설량이 78mmol 이상인 경우를 예측할 수 있으며, 이는 경제적이고 편리하면서 24시간 소변 나트륨 배설량을 대체할 수 있는 좋은 지표로 생각된다.
HEPATITIS-C VIRUS (HCV) GENOTYPE DETERMINATION - GENOTYPING VERSUS SEROTYPING
Authors: J M Pawlotsky, E Dussaix, P Simmonds, L Prescott, C Pellet, P Laurentpuig, C Labonne, J Remire, F Darthuy, J Duval, C Buffet, J P Etienne, D Dhumeaux
Journal: Hepatology (1995)
ENDOSCOPIC CONTROL OF POLYP BURDEN WITH SMALL-BOWEL ENDOSCOPY IN PEUTZ-JEGHERS SYNDROME. A THIRTY-YEAR EXPERIENCE IN A TERTIARY REFERRAL CENTER
Authors: P Cortegoso Valdivia, T Sprujevnik, L Venezia, CG De Angelis, M Pennazio
Journal: Endoscopy (2020)

Aims We investigated the clinical outcome of small-bowel endoscopy as part of an oncological surveillance program in a large series of PJS patients.
PET-CT Improved High-risk Prostate Cancer Staging in Trial
Authors: Jennifer Abbasi
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adding NT-proBNP to the Revised Cardiac Risk Index improved prediction of CV events after noncardiac surgery
Authors: Susmita Paladugu, Anthony A. Donato
Journal: Annals of Internal Medicine (2020)

Duceppe E, Patel A, Chan MTV, et al. Preoperative N-terminal pro-B-type natriuretic peptide and cardiovascular events after noncardiac surgery: a cohort study. Ann Intern Med. 2020;172:96-104. 31869834.
ENDOSCOPIC TREATMENT OF POST-CHOLECYSTECTOMY BILE LEAKS: A TERTIARY CENTER EXPERIENCE OF 100 CASES
Authors: I Khamaysi, H Haidar, E Manasa, A Suissa, K Yassin, Y Kluger
Journal: Endoscopy (2020)

Aims Post-cholecystectomy bile leak is relatively a well-known surgical complication. Several potential treatment modalities for such leaks are used. The early use of ERCP to exclude significant bile-duct injury and to treat the leak by various endoscopic means is supported by a large bulk of data. However, there is no consensus as to the optimal endoscopic intervention.