tbuckley/cabot-search huggingface dataset:
AB1215 Minimal invasive ultrasound-guided parotid gland biopsy in cadavers done by rheumatologists
Authors: R. Micheroli, U. Wagner, M. Mueller-Gerbl, M. Toranelli, C. Marx, G.A.W. Bruyn, S. Jousse-Joulin, G. Tamborrini
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> In daily practice, surgical biopsy of minor salivary glands is routinely performed for the diagnosis of Sjögren's syndrome. The classification criteria for Sjögren's syndrome imply specific positive labial salivary gland biopsy findings. Surgical biopsies of the minor labial glands may result in up to 6% of patients in various complications, e.g. numbness of the lower lip. On the other hand, adverse events following core needle biopsies of the parotid gland in non-rheumatological settings were reported as very rare. Even so parotid gland biopsies require a more demanding surgical expertise mainly to protect the facial nerve. <h3>Objectives</h3> The objective of this study was to assess the feasibility and to determine the presence of parotid gland tissue in minimally invasive ultrasound-guided parotid gland biopsies in cadavers performed by rheumatologists using histology as a gold standard. <h3>Methods</h3> Two senior rheumatologists obtained under direct ultrasound visualisation in in-plane technique biopsies of 8 parotid glands from 4 different cadavers using a core biopsy needle (core biopsy needle 18G). One biopsy per gland was taken and was subsequently stored. The direction of the bioptic access is shown in Figure 1. The specimen underwent histological examination by an experienced pathologist. <h3>Results</h3> All histological exams showed typical parotid gland tissue. Notably, no facial nerve tissue or major vessels could be detected in the biopsy material. <h3>Conclusions</h3> In this cadaveric feasibility study, we demonstrated that minimally invasive ultrasound guided parotid core biopsy is a highly precise and easy method to obtain salivary gland tissue. <h3>References</h3> [1] Shiboski C. H. et al, 2016American College of Rheumatology/European League Against Rheumatism Classification Criteria for Primary Sjogren's Syndrome. Arthritis Rheumatol. 2017 Jan;69(1):35–45. [2] Kim H.Jet al, Ultrasound-Guided Core Needle Biopsy in Salivary Glands: A Meta-analysis, Laryngoscope, 00:000–000, 2017. <h3>Disclosure of Interest</h3> None declared
TAM Inhibitor ONO-7475 Combination with Sorafenib Is Effective Using in Vitro and In Vivo Models of FLT3 ITD Acute Myeloid Leukemia
Authors: Peter P. Ruvolo, Huaxian Ma, Vivian Ruvolo, Xiaorui Zhang, Hong Mu, Tomoko Yasuhiro, Kohei Tanaka, Toshio Yoshizawa, Weiguo Zhang, Jorge E. Cortes, Michael Andreeff, Sean M Post
Journal: Blood (2018)
FRI0052 Higher uric acid is associated with a lower disease activity in rheumatoid arthritis patients
Authors: A. Al-Herz, A. Aldei, K. Saleh, A. Al-Awadhi, W. Al-Kandari, E. Hasan, A. Ghanem, M. Hussain, E. Nahar, F. Abutiban, A. Alenizi, Y. Ali, H. Alhajeri, S. Hayat, A. Khadrawy, A. Fazal, K. Mokaddem, A. Zaman, G. Mazloum, Y. Bartella, S. Hamed, R. Alsouk, A. Al-Saber
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> An association between serum uric acid (UA) and disease activity in rheumatoid arthritis (RA) patients has not been well studied. <h3>Objectives</h3> We describe RA patients with high and normal UA and study its association with RA activity. <h3>Methods</h3> Adult RA patients from The Kuwait Registry for Rheumatic Diseases (KRRD) who satisfied the ACR classification criteria for RA from four major hospitals were studied from February 2013 through April 2017. Patients with recorded UA were identified. Visits with documented UA levels were included. UA of ≥357 µmol/L (6 mg/dL) was considered high. Statistical correlations were made. <h3>Results</h3> A total of 564 RA patients with 2710 hospital visits and available UA were identified, 353 (62.6%) females. Mean age 50.8±11.5 years and disease duration 10.5±2.9 years. Mean DAS28 was 2.9±1.2 and mean HAQ-DI 0.77±0.67. Rheumatoid factor (RF) was positive in 431/564 (76.4%) and anti-cyclic citrullinated peptide antibodies (ACPA) in 374/564 (66.3%). Mean UA was 271±78 µmol/L with 12.7% readings being high. There were more males among patients with high UA than with normal UA(56% vs 36%,p&lt;00.1) with no difference in age. UA was negatively correlated with DAS28(p&lt;0.001), CDAI(p&lt;0.001), SDAI(p=0.038), ESR(p=0.034), VAS pain(p=0.049), morning stiffness(p=0.033), patient's global assessment(p=0.006), physician's global assessment(p=0.033), number of tender joints(p&lt;0.001) and number of swollen joints(p&lt;0.001). There was no significant correlation with RF, ACPA or HAQ. The use of steroid, synthetic and biologic antirheumatic drugs, either individually or as a class, was similar among patients with high and normal UA. <h3>Conclusions</h3> RA patients with a higher UA had a lower disease activity despite using similar antirheumatic drugs. Reasons behind such association need to be further studied. <h3>Disclosure of Interest</h3> None declared
PET/CT-guided percutaneous biopsy for diagnosis of MPNST in Neufibromatosis Type 1 (NF1).
Authors: Patrick Combemale, Mehdi Brahmi, Philippe Thiesse, Thomas Mognetti, Stephane Pinson, Jean-Yves Blay, Anne-Valerie Decouvelaere, Dominique Ranchere
Journal: Journal of Clinical Oncology (2015)

e21513 Background: MPNST (Malignant Peripheral Nerve Sheath Tumor) is one of the most frequent causes of death in patients (pts) with NF1. Early detection is crucial, as complete surgical resection is the only curative treatment. However, diagnosis between BPNST (Benign Peripheral Nerve Sheath Tumor) and MPNST by clinical symptoms or conventional CT and MRI (including whole-body MRI protocol) is difficult. PET/CT, with a T/L (Tumor/Liver) SUVmax ratio > 1.5, provides a high negative predictive value but it is not specific enough for NF1-related MPNST diagnosis. Thus, a formal proof of malignant transformation by histological analysis is necessary before surgical excision, which could be mutilating. We aimed to investigate the effectiveness and complications of PET/CT-guided percutaneous biopsy (PET/CT GPB) technique for MPNST NF1-related diagnosis. Methods: PET/CT GPB procedures performed on 26 NF1 pts with a clinical suspicion of MPNST and a suspect lesion on PET/CT (T/L SUVmaxratio > 1.5) were retrospectively evaluated. Localization of the supposed transformed area was determined by PET/CT. Stereotactic (ultrasonic and CT control) core biopsy technique was used, with local anesthesia. Results: Diagnostic results were achieved in all patients. Histopathological results of biopsy were malignant (MPNST) in 17 cases and benign (atypical BPNST) in 9 cases. No complications were related. A surgical resection was perfomed in 18 pts, taking the fine needle biopsy scare. Regarding the other 8, there were 6 locally advanced/metastatic MPNST treated by chemo/radiotherapy and 2 BPNST with a sufficient follow up to confirm the benignity. PET/CT GPB provided 25 accurate diagnosis and 1 false negative case (“atypical” BPNST on the biopsy and MPNST on the operated tumor), resulting in a diagnostic accuracy rate of 96%. This false negative case may be explained by the high heterogeneity of the tumor: benign areas contiguous to malignant areas and associated to an important inflammation. Conclusions: PET/CT GPB provides a rapid, relatively non-traumatic and effective procedure in obtaining diagnosis of NF1-related MPNST. It is the most reliable approach for early detection of MPNST, reducing the need for more invasive surgical procedure.
SAT0018 Blood chemokine system profile associated with disease activity in rheumatoid arthritis
Authors: A. Petrackova, G. Gabcova, M. Skacelova, Z. Mikulkova, A. Smrzova, M. Schubertova, F. Mrazek, P. Horak, E. Kriegova
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Chemokine receptors and their chemokine ligands (chemokine system), key mediators of inflammatory and immune cell trafficking, are involved in the pathogenesis of rheumatoid arthritis (RA). There is still limited information of blood chemokine system signature associated with disease activity. <h3>Objectives</h3> To identify RA-associated chemokine system signature using highly sensitive multiplex Proximity Extension ImmunoAssay (PEA) in serum together with analysis of CCR5, CCR6 and CXCR3 expression in blood cell subsets and assess its relationship with disease activity as evaluated by activity score (DAS28). <h3>Methods</h3> We investigated the serum levels of 92 inflammation-related proteins in 78 Czech patients with RA by PEA (Proseek Multiplex, Olink Bioscience, Sweden). Disease activity was assessed by means of DAS28 and subgroups were formed based on the disease activity, where DAS28 of ≥3.2 was taken as active RA (inactive RA, n=40; active RA, n=38). The expression of CCR5, CCR6 and CXCR3 receptors were analysed using 6-colour flow cytometry (BD FACSCanto II) on T and B lymphocytes, NK, dendritic cells, and monocytes in peripheral blood from 11 patients with active RA and 9 age-matched healthy control subjects. Statistical tests (Mann-Whitney U test, Spearman correlation) were performed using GenEx (Sweden) and GraphPad Prism 5.01 (CA, USA). <i>P</i>-value≤0.05 was considered as significant. <h3>Results</h3> In patients with active RA, 16 serum proteins were upregulated (<i>P<sub>corr</sub></i> ≤0.05). Top-ranked proteins distinguishing active and inactive RA were CCL20, CXCL9, CCL7, CXCL10, IL-6, sCDCP1, and CXCL1 (<i>P<sub>corr</sub></i> &lt;0.03). Levels of all these proteins positively correlated with disease activity (r&gt;0.30, p&lt;0.006) and the best correlation was observed for chemokines CCL20 (r=0.495, p=0.000004) and CCL7 (r=0.442, p=0.00005). Based on these results we analysed the expression of corresponding chemokine receptors: CCR5, CCR6, and CXCR3 in blood cells. Expression of CCR6 was increased on CD4 +T and CD8 +T lymphocytes (p=0.008, p=0.01 respectively) and on total and activated NK cells (p=0.01, p=0.004 respectively) in active RA compared with healthy controls. Regarding CCR5, decreased percentage of CCR5 positive CD4 +T lymphocytes were registered in RA patients compared with healthy controls (p=0.008). No differences were observed in the expression of CXCR3 on investigated immune cell populations. <h3>Conclusions</h3> We identified the blood chemokine system signature associated with disease activity in RA further supporting a critical role of CCL20/CCR6 axis in the ongoing inflammation related to the disease activity in RA. <h3>Acknowledgements</h3> Grant support: MZ CR VES15–28659A, IGA_LFUP_2018_16 <h3>Disclosure of Interest</h3> None declared
Abstract 13180: Clopidogrel Use Among Older Medicare Part D Enrollees after Receipt of a Drug Eluting Coronary Artery Stent
Authors: Gregory A Roth, Nancy E Morden, Weiping Zhou, David J Malenka, Jonathan Skinner
Journal: Circulation (2010)

Background: Use of clopidogrel following percutaneous coronary intervention (PCI) with drug eluting coronary artery stent (DES) lowers the risk of stent thrombosis and death. We hypothesized that some older Americans are failing to fill a prescription for guideline-recommended clopidogrel after hospital discharge and that characteristics known at time of hospital discharge would predict this failure. Methods: A retrospective analysis was performed using a 20% sample of individuals enrolled in fee-for-service Medicare Parts A, B and D in 2006–2007. The sample was limited to those 65 and older who received a DES during an acute-care hospitalization and survived at least 90 days without admission to a nursing facility. Using logistic regression, we estimated the adjusted probability of filling a clopidogrel prescription by age, sex, race, income, warfarin use, and comorbidities. Results: We identified 23,636 individuals who received PCI with DES. Mean age was 75; 53.0% were female; 7.0% were black, 21.4% had...
AB0601 Entheses ultrasonography in tunisian primary sjÖgren’s syndrome patients
Authors: K. Ben Abdelghani, M. Chammakhi, A. Fazaa, K. Ouenniche, S. Kassab, S. Chekili, A. Lataar
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Primary Sjögren's Syndrome is an auto-immune disease characterised by dryness of the eyes and the oral cavity. Musculoskeletal manifestations are common. However, the underlying mechanism remains often unknown. <h3>Objectives</h3> The aim of the current study was to describe subclinical entheseal involvement in patients with Primary Sjögren's Syndrome via ultrasound, to calculate a modified Madrid sonography enthesitis index and to compare it with a group of healthy controls. <h3>Methods</h3> The study was conducted in the rheumatology department of Mongi Slim hospital in Tunisia, between June 2015 and December 2017, including 25 patients with Primary Sjögren's Syndrome and 25 healthy sex- and age-matched controls. Cases were defined according to the American-European Consensus Criteria for Sjögren's Syndrome. All the included subjects underwent an enthesis ultrasound exploration (EsaoteMyLab 60 machine and a 13–18 MHz linear array transducer) by a rheumatogist experimented in ultrasound. Five enthesis locations bilaterally (distal Achilles tendon, distal and proximal patellar ligaments, distal quadriceps, and brachial triceps tendons) in each patient were explored. The following elemental lesions of enthesis were evaluated: thickning, presence of calcifications, erosions, enthesophyte, loss of fibrillar pattern and power Doppler signal. The calculated index was compared by Mann-Whitney U test between cases and controls. The significance level was set at 5%. <h3>Results</h3> In our study population, the median age was 53.2±11.3 years and the median body mass index was 29.±6.4 kg/m<sup>2</sup>;. All included subjects were female. The ultrasound abnormalities in the Primary Sjögren's Syndrome were as follows: erosions in 19.2% of cases, enthesophytes in 16.4% of cases, calcifications in 6% of cases, hypoechogeneity in 2.8% of cases, thickning in 2.4% of cases, power Doppler signal in 1.6% of cases and loss of fibrillar pattern in 1.2% of cases. The total enthesitis index was 4,96±2,59among cases and 5,72±2,92 among healthy control subjects with no statistically significant difference. Considering each affected enthesis, cases had no significantly higher scores than controls. <h3>Conclusions</h3> Our study did not find a significant enthesal involvement among patients with Primary Sjögren's Syndrome that could explain the chronic indefinable pain. The diagnosis of an associated fibromyalgia should be kept in mind. <h3>Disclosure of Interest</h3> None declared
Abstract 20079: Cardioprotective Medications and Quality of Life in Peripheral Arterial Disease: Insights From Q-PAD Registry
Authors: Anwar Zaitoun, Saif Al-Najafi, Thaer Musa, Susan Szpunar, Dawn Light, Hiroshi Yamasaki, Thomas Lalonde, Rajendra H Mehta, Howard S Rosman
Journal: Circulation (2016)

Introduction: Peripheral arterial disease (PAD) has a high prevalence with increasing incidence over the last decade. The great majority of patients have co-morbidities that require them to be on cardioprotective (CP) medications. These medications (beta-blockers, ACEI/ARBS, CCB, Statins) have been shown to decrease morbidity and mortality. However, the effect of these medications on the patients’ quality of life (QOL) after percutaneous vascular intervention (PVI) has not been well studied. Methods: We conducted a retrospective study to evaluate the effects of CP medications on QOL (1-6 months) post-PVI in patients with PAD. We evaluated a total of 344 patients after we divided them into 3 groups depending on the number of CP medications they are taking. Group 1 included only patients on dual anti-platelets therapy (DAPT). Group 2 included DAPT plus only one of CP medications. Group 3 included DAPT and at least two of the CP medications. The Peripheral Arterial Questionnaire (PAQ) was used to evaluate QO...
Incorporating Tumor Characteristics to Maximize 21-Gene Assay Utility: A Cost-Effectiveness Analysis
Authors: Shi-Yi Wang, Tiange Chen, Weixiong Dang, Sarah S. Mougalian, Suzanne B. Evans, Cary P. Gross
Journal: Journal of the National Comprehensive Cancer Network (2019)

Background: Literature suggests that Oncotype DX (ODX) is cost-effective. These studies, however, tend to ignore clinical characteristics and have not incorporated population-based data regarding the distribution of ODX results across different clinical risk groups. Accordingly, this study assessed the cost-effectiveness of ODX across strata of clinical risk groups using population-based ODX data. Methods: We created state-transition models to calculate costs and quality-adjusted life years (QALYs) gained over the lifetime for women with estrogen receptor (ER)-positive, HER2-negative, lymph node-negative breast cancer from a US payer perspective. Using the Connecticut Tumor Registry, we classified the 2,245 patients diagnosed in 2011 through 2013 into 3 clinical risk groups according to the PREDICT model, a risk calculator developed by the National Health Service in the United Kingdom. Within each risk group, we then determined the recurrence score (RS) distributions (<18, 18-30, and ≥31). Other input parameters were derived from the literature. Uncertainty was assessed using deterministic and probabilistic sensitivity analyses. Results: Approximately 82.5%, 11.9%, and 5.6% of our sample were in the PREDICT low-, intermediate-, and high-risk groups, respectively. When combining these 3 groups, ODX had an incremental cost-effectiveness ratio (ICER) of $62,200 per QALY for patients aged 60 years. The ICERs, however, differed across clinical risk groups, ranging from $124,600 per QALY in the low-risk group, to $28,700 per QALY in the intermediate-risk group, to $15,700 per QALY in the high-risk group. Results were sensitive to patient age: the ICER for patients aged 45 to 75 years ranged from $77,100 to $344,600 per QALY in the PREDICT low-risk group, and was lower than $100,000 per QALY in the intermediate- and high-risk groups. Conclusions: ODX is not cost-effective for women with clinical low-risk breast cancer, which constitutes most patients with ER-positive disease.
ENHANCEMENT OF LEUKOCYTE CYTOTOXICITY AFTER EXERCISE-INDUCED ASTHMA
Authors: R Moqbel, S R Durham, R J Shaw, Garry Michael Walsh, A J Macdonald, J A Mackay, M P Carroll, A B Kay
Journal: American Journal of Respiratory and Critical Care Medicine (1986)

We have previously shown that there were elevations of neutrophil chemotactic activity (NCA) and increases in the percentages of neutrophil and monocyte complement rosettes after exercise-induced asthma (EIA). These observations suggested that leukocyte activation may occur after EIA, possibly as a result of the release of mast-cell-associated mediators. In the present study, we have attempted to establish whether neutrophils and monocytes are functionally altered after EIA as assessed by changes in their cytotoxic capacity. Cytotoxicity was assessed by a direct visual killing assay using opsonized (complement-coated) schistosomula of Schistosoma mansoni as target organisms. Neutrophils and mononuclear cells obtained from 8 patients after exercise-induced asthma (EIA+ve) had increased cytotoxicity for opsonized schistosomula for as long as 60 min after exercise. These changes were preceded by elevations in the concentrations of serum high molecular weight NCA (which were maximal at 10 min after exercise). In asthmatic patients who did not develop exercise-induced asthma (EIA-ve), no significant increases in neutrophil or mononuclear cell killing of schistosomula, or serum NCA concentrations, were observed. There was a highly significant correlation (p less than 0.001) between the reduction in FEV1 and the increases in neutrophil cytotoxicity. In 5 EIA+ve patients, administration of disodium cromoglycate (cromolyn) prior to the exercise task inhibited both the enhancement in neutrophil and mononuclear cell cytotoxicity, as well as the elevations in circulating NCA and the reductions in FEV1.(ABSTRACT TRUNCATED AT 250 WORDS)
Peroral endoscopic myotomy and fundoplication: a novel NOTES procedure
Authors: Haruhiro Inoue, Akiko Ueno, Yuto Shimamura, Anastassios Manolakis, Ashish Sharma, Shin Kono, Masayuki Nishimoto, Kazuya Sumi, Haruo Ikeda, Kenichi Goda, Manabu Onimaru, Noriko Yamaguchi, Hiroaki Itoh
Journal: Endoscopy (2019)

Abstract Background Peroral endoscopic myotomy (POEM) has become the minimally invasive endoscopic treatment for achalasia; however, gastroesophageal reflux (GER) post-POEM has been reported. A pilot study was conducted in which an endoscopic fundoplication was added to the standard POEM (POEM + F) procedure to overcome this issue. We report the technical details of POEM + F and short-term safety results. Methods POEM + F was performed in 21 patients. After completing myotomy, the endoscope was advanced from the submucosal tunnel into the peritoneal cavity. A partial mechanical barrier was created by retracting the anterior gastric wall at the esophagogastric junction with the use of endoclips and an endoloop. Results POEM + F was technically feasible in all cases and created a visually recognizable fundoplication. The clinical course after POEM + F was uneventful. No immediate or delayed complications occurred. Conclusion POEM + F may help mitigate the post-POEM incidence of GER and serve as a minimally invasive endoscopic alternative to a laparoscopic Heller-Dor procedure. This is the largest case series of peroral natural orifice transluminal endoscopic surgery without laparoscopic assistance in the human foregut.
MGTA-456, a First-in-Class Cell Therapy Produced from a Single Cord Blood Unit, Enables a Reduced Intensity Conditioning Regimen and Enhances Speed and Level of Human Microglia Engraftment in the Brains of NSG Mice
Authors: Kevin A. Goncalves, Shuping Li, Melissa L. Brooks, Sharon L. Hyzy, Anthony E. Boitano, Michael P. Cooke
Journal: Blood (2018)
FRI0431 Dysregulation of lymphangiogenetic factors in systemic sclerosis patients with pulmonary arterial hypertension
Authors: A.-M. Hoffmann-Vold, H. Didriksen, H. Fretheim, E. Gude, V. Palchevskiy, T. Garen, Ø. Midtvedt, A. Andreassen, J. Belperio, Ø. Molberg
Journal: Annals of the Rheumatic Diseases (2018)

FRI0428 -Table 2. Associations between mean number of capillaries at baseline and disease activity (ESSG score 2003) at FU (linear regression) Predictors B (95% CI) p m_nr/pat rater 2 À0.45 (-0.834,-0.07)0.02 m_nr/3rd dom rater 2 À0.33(À0.62,-0.03)0.03 m_nr/4th non-dom rater 2 À0.27 (-0.57,0.02)0.07 Conclusions:The mean number of capillaries had a good association with the history of DUs and predicted disease activity at 6 months follow-up.The m_nr/pat performed better in our analysis than the m_nr/3rd dom and m_nr/4th non-dom, however these could be used alternatively in clinical practice as they are less time consuming.
Efficacy and Safety of Autologous Stem Cell Transplantation in Elderly Patients with Multiple Myeloma in the Era of Novel Agents
Authors: Shohei Mizuno, Koji Kawamura, Ichiro Hanamura, Kazutaka Sunami, Takehiko Mori, Fumihiko Nakamura, Shinsuke Iida, Hideyuki Nakazawa, Masanori Makita, Shinichi Kako, Masashi Sawa, Yasunori Ueda, Hiroyuki Takahashi, Yoshinobu Kanda, Tatsuo Ichinohe, Yoshiko Atsuta, Hiroyuki Takamatsu, Akiyoshi Takami
Journal: Blood (2018)