tbuckley/cabot-search huggingface dataset:
Interleukin-35 Promotes Macrophage Survival and Improves Wound Healing After Myocardial Infarction in Mice
Authors: Daile Jia, Hao Jiang, Xinyu Weng, Jian Wu, Peiyuan Bai, Wenlong Yang, Zeng Wang, Kai Hu, Aijun Sun, Junbo Ge
Journal: Circulation Research (2019)

Rationale: Targeting inflammation has been shown to provide clinical benefit in the field of cardiovascular diseases. Although manipulating regulatory T-cell function is an important goal of immunotherapy, the molecules that mediate their suppressive activity remain largely unknown. IL (interleukin)-35, an immunosuppressive cytokine mainly produced by regulatory T cells, is a novel member of the IL-12 family and is composed of an EBI3 (Epstein-Barr virus–induced gene 3) subunit and a p35 subunit. However, the role of IL-35 in infarct healing remains elusive. Objective: This study aimed to determine whether IL-35 signaling is involved in healing and cardiac remodeling after myocardial infarction (MI) and, if so, to elucidate the underlying molecular mechanisms. Methods and Results: IL-35 subunits (EBI3 and p35), which are mainly expressed in regulatory T cells, were upregulated in mice after MI. After IL-35 inhibition, mice showed impaired infarct healing and aggravated cardiac remodeling, as demonstrated by a significant increase in mortality because of cardiac rupture, decreased wall thickness, and worse cardiac function compared with wild-type MI mice. IL-35 inhibition also led to decreased expression of α-SMA (α-smooth muscle actin) and collagen I/III in the hearts of mice after MI. Pharmacological inhibition of IL-35 suppressed the accumulation of Ly6C low and major histocompatibility complex II low /C-C motif chemokine receptor type 2 − (MHC II low CCR2 − ) macrophages in infarcted hearts. IL-35 activated transcription of CX3CR1 (C-X3-C motif chemokine receptor 1) and TGF (transforming growth factor) β1 in macrophages by inducing GP130 signaling, via IL12Rβ2 and phosphorylation of STAT1 (signal transducer and activator of transcription family) and STAT4 and subsequently promoted Ly6C low macrophage survival and extracellular matrix deposition. Moreover, compared with control MI mice, IL-35–treated MI mice showed increased expression of α-SMA and collagen within scars, correlating with decreased left ventricular rupture rates. Conclusions: IL-35 reduces cardiac rupture, improves wound healing, and attenuates cardiac remodeling after MI by promoting reparative CX3CR1 + Ly6C low macrophage survival.
IMPLANTABLE CARDIOVERTER DEFIBRILLATOR IS ASSOCIATED WITH HIGHER RISK OF DEVICE INFECTION THAN PERMANENT PACEMAKER: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Pattara Rattanawong, Jakrin Kewcharoen, Poemlarp Mekraksakit, Raktham Mekritthikrai, Narut Prasitlumkum, Wasawat Vutthikraivit, Jonathan Dworkin
Journal: Journal of the American College of Cardiology (2019)
DOES NON-INVASIVE CARDIAC OUTPUT MONITORING (NICOM) CORRELATE WITH STANDARD INVASIVE HEMODYNAMIC MONITORING IN PATIENTS WITH ACUTE DECOMPENSATED HEART FAILURE?
Authors: Aniket Rali, Tyler Buechler, Bridget Van-Gotten, Emily Burgen, John Chen, Zubair Shah, Nicholas Haglund, Andrew Sauer
Journal: Journal of the American College of Cardiology (2019)
MACHINE LEARNING-BASED CARDIOVASCULAR EVENT PREDICTION FOR PERCUTANEOUS CORONARY INTERVENTION
Authors: Yijiang Zhou, Ruoyu Zhu, Xiaojun Chen, Xiaolei Xu, Qiwen Wang, Liujun Jiang, Jianhua Zhu, Jian Wu, Hui Yan, Li Zhang
Journal: Journal of the American College of Cardiology (2019)
PARADOXICAL EMBOLIC INFERIOR ST SEGMENT ELEVATION MYOCARDIAL INFARCTION AS THE INITIAL PRESENTATION OF A SECUNDUM ATRIAL SEPTAL DEFECT
Authors: Solomon Seifu, Neeraj Jain, Frederick Helmcke, Murtuza Ali, Kiran Mallula, Pedro Cox-Alomar
Journal: Journal of the American College of Cardiology (2019)
Stage of disease and initial surgical intervention in colon cancer patients: An exploratory analysis of the SEER database.
Authors: Rachel Gray Denneny, David J. Delgado, Victoria Nguyen, Brandon George, Edith P. Mitchell, Jay Subramoney
Journal: Journal of Clinical Oncology (2019)

e15170 Background: Colorectal cancer (CRC) is the third-leading cause of cancer-related deaths in the United States. CRC’s decreasing mortality rate has been attributed to increased screening and early detection. This study explored the association between stage at diagnosis with initial surgical intervention for patients (pts) with colon cancer (CC), using data extracted from the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) data. Methods: Retrospective cohort study using the SEER database from 1998-2015. Included were pts with CC, aged 18 or older, and with disease in either the proximal or distal colon. Pts with rectal cancer were excluded. Stage was defined as local, regional versus distant, and initial treatment was defined as none versus any surgery. Multivariable logistic regression was used to describe the association between stage and initial surgical intervention, controlling for pts and tumor characteristics. Results: 354,640 CC pts were included in this analysis: 46%(localized), 36%(regional), 18%(distant), and 92.45%(received surgery). Multivariable analysis indicated that pts with regional disease were more likely to receive initial surgical intervention compared to those with localized disease (OR = 4.49,95% CI = 4.24,4.77). Pts with distant stage of disease were less likely to receive surgery compared to those with localized disease (OR = 0.11,CI = 0.11,0.12). Other factors significantly associated with an increased likelihood of initial surgical intervention included mucinous adenocarcinoma histology, papillary adenocarcinoma histology, having a partner relationship, adenomatous polyps on histology, white race, female sex, and lesion location in the proximal colon. Additionally, African American pts were significantly less likely than white pts to receive surgery as an initial intervention for colon cancer (OR = 0.76,CI = 0.73,0.79). Conclusions: We conclude that distant stage at diagnosis was associated with reduced odds of initial surgical intervention. This highlights the importance of screening and early detection to identify pts with operable disease and as a method of decreasing mortality.
DUAL-CHAMBER PACING FOR POSTOPERATIVE RESIDUAL LEFT VENTRICULAR GRADIENT AFTER AORTIC VALVE REPLACEMENT AND CONCOMITANT SEPTAL MYECTOMY FOR SEVERE AORTIC STENOSIS AND SUBVALVULAR OBSTRUCTION
Authors: Hikaru Imafuku, Junya Komatsu, Ayaka Machida, Ryuichiro Imai, Yoko Nakaoka, Sho-Ichi Kubokawa, Hiroyuki Irie, Kazuya Kawai, Naohisa Hamashige, Yoshinori Doi
Journal: Journal of the American College of Cardiology (2019)
Long-Term Efficacy and Safety (5 Years) in RESPONSE, a Phase 3 Study Comparing Ruxolitinib (rux) with Best Available Therapy (BAT) in Hydroxyurea (HU)-Resistant/Intolerant Patients (pts) with Polycythemia Vera (PV)
Authors: Jean-Jacques Kiladjian, Pierre Zachée, Masayuki Hino, Fabrizio Pane, Tamas Masszi, Claire N. Harrison, Ruben A. Mesa, Carole B. Miller, Francesco Passamonti, Simon Durrant, Martin Griesshammer, Keita Kirito, Carles Besses, Beatriz Moiraghi, Elisa Rumi, Vittorio Rosti, Igor W. Blau, Nathalie Francillard, Tuochuan Dong, Monika Wroclawska, Alessandro M. Vannucchi, Srdan Verstovsek
Journal: Blood (2018)
Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers
Authors: Conan G. Kinsey, Soledad A. Camolotto, Amelie M. Boespflug, Katrin P. Guillen, Mona Foth, Amanda Truong, Sophia S. Schuman, Jill E. Shea, Michael T. Seipp, Jeffrey T. Yap, Lance D. Burrell, David H. Lum, Jonathan R. Whisenant, G. Weldon Gilcrease, Courtney C. Cavalieri, Kaitrin M. Rehbein, Stephanie L. Cutler, Kajsa E. Affolter, Alana L. Welm, Bryan E. Welm, Courtney L. Scaife, Eric L. Snyder, Martin McMahon
Journal: Nature Medicine (2019)
MICROVESICLES LARGER THAN 200NM RESCUE CARDIOMYOCYTES FROM DOXORUBICIN INJURY IN A PATIENT-SPECIFIC MODEL OF ANTHRACYCLINE INDUCED CARDIOMYOPATHY
Authors: Connor O'Brien, Liye Shi, Mehmet Ozgun, Evgeniya Vaskova, Michelle Santoso, Ji Hye Jung, Gentaro Ikeda, Utkan Demirci, Phillip Yang
Journal: Journal of the American College of Cardiology (2019)
MANAGEMENT OF PATIENTS WITH SEVERE AORTIC STENOSIS AND CONCOMITANT TRICUSPID REGURGITATION UNDERGOING TAVR OR SAVR
Authors: Mohanad Hamandi, Robert L. Smith, William H. Ryan, Jordan Wooley, Anupama Vasudevan, Paul A. Grayburn, Timothy J. George, Karim Al Azizi, Kelly A. Hutcheson, Katherine B. Harrington, Justin M. Schaffer, William T. Brinkman, Molly A. Szerlip, Srinivasa Potluri, David O. Moore, J. Michael DiMaio, Michael Mack
Journal: Journal of the American College of Cardiology (2019)
Diabulimia: the world’s most dangerous eating disorder
Authors: Ingrid Torjesen
Journal: BMJ (2019)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Diabulimia: the world's most dangerous eating disorder Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
THE ROLE OF INTERMUSCULAR FAT IN REDUCED EXERCISE CAPACITY IN CANCER SURVIVORS
Authors: Kerryn Reding, Peter Brubaker, Ralph Dagostino, Dalane Kitzman, William W. Hundley, Barbara Nicklas, Jennifer H. Jordan, Dale J. Langford, Michael Grodesky, W. Hundley
Journal: Journal of the American College of Cardiology (2019)
Paleogenomics: reconstruction of plant evolutionary trajectories from modern and ancient DNA
Authors: Caroline Pont, Stefanie Wagner, Antoine Kremer, Ludovic Orlando, Christophe Plomion, Jerome Salse
Journal: Genome biology (2019)

How contemporary plant genomes originated and evolved is a fascinating question. One approach uses reference genomes from extant species to reconstruct the sequence and structure of their common ancestors over deep timescales. A second approach focuses on the direct identification of genomic changes at a shorter timescale by sequencing ancient DNA preserved in subfossil remains. Merged within the nascent field of paleogenomics, these complementary approaches provide insights into the evolutionary forces that shaped the organization and regulation of modern genomes and open novel perspectives in fostering genetic gain in breeding programs and establishing tools to predict future population changes in response to anthropogenic pressure and global warming.
DELIRIUM AFTER TRANSCATHETER AORTIC VALVE IMPLANTATION AND ITS EFFECT ON CLINICAL OUTCOME AND LONG-TERM MORTALITY
Authors: Kees Van Der Wulp, Marleen H. van Wely, Lars van Heijningen, Yvonne Schoon, Michel W.A. Verkroost, Helmut R. Gehlmann, Leen A.F.M. Van Garsse, Priya Vart, Wim J. Morshuis, Marcel G.M. Olde-Rikkert, Peter C. Kievit, Niels van Royen
Journal: Journal of the American College of Cardiology (2019)
SACUBITRIL/VALSARTAN VERSUS ENALAPRIL IN PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION: FINDINGS FROM AWAKE-HF, A RANDOMIZED, CLINICAL TRIAL USING A WEARABLE BIOSENSOR
Authors: Raj M. Khandwalla, Daniel Grant, Kade Birkeland, J. Thomas Heywood, Kevin McCague, Emmanuel Fombu, Robert L. Owens, Steven Steinhubl
Journal: Journal of the American College of Cardiology (2019)
RESIDUAL MYOCARDIAL ISCHEMIA AFTER PCI: EFFECTS OF IVABRADINE ASSESSED BY STRESS ECHOCARDIOGRAM
Authors: Fabio Infusino, Simone Calcagno, Mariateresa Pucci, Paolo Severino, Pasqualina Bruno, Viviana Maestrini, Massimo Mancone, Gennaro Sardella, Francesco Fedele
Journal: Journal of the American College of Cardiology (2019)
Workforce crisis: “punitive” cuts to pension tax relief must be reversed, say consultants
Authors: Gareth Iacobucci
Journal: BMJ (2019)

The government must reverse damaging changes to pension regulations that are imposing “excessive rates of taxation” on hospital doctors and exacerbating the medical workforce crisis, consultants have urged.

The BMA has warned that changes to rules on pension allowance introduced in 2016 have landed consultants with huge unexpected tax bills and deepened the retention crisis in the profession.1

Some 60% of the 4000 consultants in England who responded to a recent BMA survey said that they were considering early retirement, and many cited the penalties incurred by breaching annual and lifetime pension allowance limits as a key reason.

A motion passed by the annual BMA consultants conference on 27 …
Breast Cancer Screening Using Digital Breast Tomosynthesis
Authors: Manisha Bahl, Constance D. Lehman
Journal: JAMA Oncology (2019)

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Treatment Patterns and Outcomes of Unselected Elderly Acute Myeloid Leukemia (AML) Patients Referred to a Combined Acute Leukemia and Hematopoietic Stem Cell Transplant (HSCT) Program
Authors: Scott R Solomon, Katelin C Jackson, Xu Zhang, Melhem Solh, Asad Bashey, H. Kent Holland, Lawrence E Morris
Journal: Blood (2018)
MITRAL VALVE CLIP CLOSURE ORIFICES YIELD THE SAME HEMODYNAMIC RESULTS IRRESPECTIVE OF DIFFERENCES IN AREA: IMPLICATIONS FOR CALCULATION OF MITRAL VALVE AREA BY CONTINUITY EQUATION
Authors: Sarma Singam, Kendra Grubb, Michael Flaherty, Dana M. Settles, Marcus Stoddard
Journal: Journal of the American College of Cardiology (2019)
TEMPORAL TRENDS IN CLINICAL AND FINANCIAL BURDEN OF HEART FAILURE HOSPITALIZATIONS IN CHRONIC INFLAMMATORY DISEASES: INSIGHTS FROM NATIONWIDE INPATIENT SAMPLE 2004-2016
Authors: Aditya A. Joshi, Joseph Lerman, Aparna Sajja, Amit Dey, Maria Patarroyo, Amresh Raina
Journal: Journal of the American College of Cardiology (2019)
LONG-TERM SYSTEMIC BLOOD PRESSURE AFTER ENDOVASCULAR STENTING OF AORTIC COARCTATION: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Timion Meijs, Evangeline Warmerdam, Martijn Slieker, Gregor Krings, Mirella Molenschot, Folkert Meijboom, Gertjan Sieswerda, Pieter Doevendans, Berto Bouma, Robbert de Winter, Barbara Mulder, Michiel Voskuil
Journal: Journal of the American College of Cardiology (2019)
Abstract 20127: Long-term Cardiovascular Outcomes and Prognostic Factors in Patients With Collagen Disease Who Underwent PCI
Authors: Shunsuke Maruta, Tomozo Koizumi, Akira Sato, Kazutaka Aonuma
Journal: Circulation (2017)

Background: Although patients with collagen disease have an increased risk of cardiovascular disease because of chronic inflammation, their prognosis and prognostic factors are fully unknown after ...
Abstract 17110: Risk Factors for Hepatic Fibrosis in Children and Adolescents After Fontan Operation
Authors: David J Goldberg, Lea F Surrey, Henry C Lin, Andrew C Glatz, Michael L O'Byrne, Jonathan J Rome, Katie Dodds, Elizabeth Rand, Pierre Russo, Jack Rychik
Journal: Circulation (2015)

Introduction: Congestive hepatopathy is increasingly recognized as a complication of Fontan physiology. Prospective data regarding the incidence of hepatopathy and risk factors for its development are lacking. Methods: Liver biopsies were obtained as part of a routine program of comprehensive end-organ evaluation offered to all patients &gt;10 years after Fontan operation (FO) through the Single Ventricle Survivorship Program. Evaluation included cardiac catheterization and contemporaneous percutaneous liver biopsy. Quantitative determination of hepatic fibrosis was performed using Sirius red staining for collagen with automated calculation of percent positive staining per slide. Patient specific characteristics, echocardiographic findings, and hemodynamic measures were assessed and evaluated as potential risk factors for collagen deposition using Pearson correlation. Differences in collagen deposition (%CD) between subgroups were assessed using the student t-test. Results: The cohort consisted of 67 patients (36 male) at mean age of 17.3 ±4.5 years and mean time from Fontan of 14.9 ±4.5 years. Right ventricular morphology was present in 37 subjects; 30 with hypoplastic left heart syndrome. Mean %CD by Sirius red staining was 23.8 ±9.5% (range 8.7-49.4%) as compared to 2.6 ±0.3% in controls. There was significant correlation between time from Fontan and degree of Sirius red staining (r=0.33, p=0.006). Serum liver enzymes and platelet count did not correlate with %CD. The median inferior vena cava (IVC) pressure was 13 mmHg (range 6-24 mmHg) and did not correlate with %CD. There was no difference in %CD between those with a measured IVC pressure ≥13 mmHg versus those with a pressure &lt;13 mmHg. There was no difference in %CD based on ventricular morphology or severity of atrioventricular valve insufficiency. Conclusion: In this cohort of predominantly asymptomatic children and adolescents electively evaluated after FO, all exhibited evidence for hepatic fibrosis as measured by collagen deposition in the liver. Time from FO was the only factor in this cohort that was significantly associated with collagen. These findings demonstrate that liver fibrosis is an inherent feature of Fontan physiology and that the degree of fibrosis increases over time.
IMPLANTABLE CARDIOVERTER-DEFIBRILLATORS FOR CHILDREN WITH CARDIAC CONDITIONS ASSOCIATED WITH HIGH RISK FOR SUDDEN CARDIAC DEATH: A COST-EFFECTIVENESS ANALYSIS
Authors: Meredith Boulos, Alyssa Hersh, David Toffey, James Sargent, Eric Stecker, Stephen Heitner, Aaron Caughey, Seshadri Balaji
Journal: Journal of the American College of Cardiology (2019)
THE ASSOCIATION BETWEEN POST-PROCEDURAL STENT ASYMMETRY AND SUBSEQUENT STENT COVERAGE AND NEOINTIMAL HYPERPLASIA ASSESSED BY OPTICAL COHERENCE TOMOGRAPHY: THE EGO-BIOFREEDOM AND OCT-ORION STUDIES
Authors: Mitsuaki Matsumura, Bei Zhao, Akiko Maehara, Frankie Tam, Yangbo Liu, Shun-Ling Kong, Gary Mintz, Stephen Lee
Journal: Journal of the American College of Cardiology (2019)
USING CARDIAC IMPLANTABLE ELECTRONIC DEVICE TO NONINVASIVELY PERFORM ELECTROPHYSIOLOGY STUDY TO REDUCE PROCEDURAL RISK IN A PATIENT WITH RIGHT ATRIAL LEAD THROMBUS AND PULMONARY EMBOLISM
Authors: Asim Ahmed, Shiv Bagga, Brad Clark, Jasen Gilge, Benzy Padanilam
Journal: Journal of the American College of Cardiology (2019)
Abstract 365: Potential Relationship Between Nitric Oxide Bioactivity And Kidney Function Following Cardio-pulmonary Bypass
Authors: Andrew J Moyal, Alfred Hausladen, Ryan Nazemian, Lin Zhu, Edwin Pacheco Colon, James Reynolds
Journal: Circulation Research (2018)

Background: Impaired kidney function is frequently observed in heart surgery patients following cardio-pulmonary bypass. Previous studies by our group have linked acute reductions in nitric oxide bioactivity, specifically declines in the main regulator of tissue blood flow S-nitrosohemoglobin (SNO-Hb), to reductions in kidney oxygenation and blood flow and subsequent renal impairment. For the current study, we hypothesized that components of the bypass procedure (viz. transfusion and red blood cell trauma) would reduce circulating SNO-Hb levels with the magnitude of this reduction correlating with markers of kidney function and patient outcome. Methods: After obtaining written informed consent, blood samples were obtained before and during bypass and on post-operative day (POD) 1. In addition to quantifying SNO-Hb samples were analyzed for change in kidney function (estimated glomerular filtration rate; eGFR), and plasma erythropoietin (EPO) concentration. Status and outcome data were secured from the patients’ medical record. Results: In the patients studied to date (n=30), there was a significant decline in SNO-Hb concentration by POD 1, the level of which inversely correlated with ICU stay (R=-0.32). In addition, there was a direct correlation between SNO-Hb and eGFR on PODs 1 &amp; 2 (R=0.48 and 0.30, respectively), i.e. lower SNO-Hb tracked with reductions in kidney function. Consistent with a presumed reduction in kidney oxygenation, we observed a significant rise in plasma EPO levels when coming off pump that were sustained into POD 1. Furthermore, the rise in EPO was inversely correlated with both SNO-Hb (R=-0.53) and eGFR (R=-0.55). Conclusion: CPB decreases SNO-Hb and is associated with kidney dysfunction and worse patient outcome (e.g. increased ICU stay). While the mechanism for this decline remains to be determined, the results suggest that therapies directed at maintaining or increasing NO bioactivity could improve outcome in adult cardiac surgery patients.
Abstract 417: Targeting the NAD/NADH Ratio for Heart Failure Therapy
Authors: Matthew A Walker, Outi Villet, Rong Tian
Journal: Circulation Research (2018)

Energy deficiency and mitochondrial dysfunction are strongly implicated in the development of heart failure (HF). Yet, the exact mechanisms remain poorly understood. Recently, a causal relationship between loss of cardiac NAD(H) homeostasis and mitochondrial dysfunction have been proposed in HF. A number of studies have demonstrated the benefit of raising NAD levels prior to or at the time of inducing heart failure, but it is unknown whether this strategy benefits hearts with established or pre-existing dysfunction. Therefore, in the present study we increased NAD level in wild-type (WT) mice after pathological hypertrophy and dysfunction were induced by transverse aortic constriction (TAC) surgery. WT mice were treated daily for six-weeks with nicotinamide riboside (NR) starting four-weeks after TAC. The NR treatments significantly elevated NAD level in the TAC hearts (3.1 fold, n=4) compared to vehicle treated mice, accompanied by an improvement in fractional shortening (FS) (sham vehicle 51%±2% vs TAC Vehicle 31%±3% vs TAC NR 43%±5%, n=4 each group). Most evidence thus far suggest the benefit of raising NAD level in the failing heart involves activation of sirtuin 3 (Sirt3), a NAD dependent deacylase. We hypothesize there are Sirt3 independent mechanisms that are activated by increasing NAD levels to benefit the failing heart. To test this hypothesis, we treated Sirt3 deficient (Sirt3-/-) mice with NR starting four-weeks after TAC surgery and extended the study to ten-weeks post TAC. NR treatments elevated cardiac NAD level (2.9-fold, n=4) compared to vehicle treated controls. This correlated with lowered global protein acetylation in the hearts and an improvement in FS (sham vehicle 50%±5% vs TAC vehicle 24%±6% vs TAC NR 41%±8%). We also looked at mitochondrial function in Sirt3-/- mice ten-weeks after TAC ± NR treatments and observed an increase in state 3 ADP-stimulated respiration in the NR treated Sirt3-/- mice (sham vehicle 183±17 vs TAC vehicle 103±23 vs TAC NR 127±21 nmol/min/mg). These findings suggest increasing NAD can improve cardiac function through Sirt3 independent mechanisms including one that enhances mitochondrial respiration. Further elucidation of these mechanisms could identify novel NAD sensitive therapeutic targets.