tbuckley/cabot-search huggingface dataset:
Clinical value of pre‐discharge bio‐adrenomedullin as a marker of residual congestion and high risk of heart failure hospital readmission
Authors: Paloma Pandhi, Jozine M. ter Maaten, Johanna E. Emmens, Joachim Struck, Andreas Bergmann, John G. Cleland, Michael M. Givertz, Marco Metra, Christopher M. O'Connor, John R. Teerlink, Piotr Ponikowski, Gad Cotter, Beth Davison, Dirk J. van Veldhuisen, Adriaan A. Voors
Journal: European Journal of Heart Failure (2019)

Abstract Aims Recently, bio‐adrenomedullin (bio‐ADM) was proposed as a congestion marker in heart failure (HF). In the present study, we aimed to study whether bio‐ADM levels at discharge from a hospital admission for worsening HF could provide additional information on (residual) congestion status, diuretic dose titration and clinical outcomes. Methods and results Plasma bio‐ADM was measured in 1236 acute HF patients in the PROTECT trial at day 7 or discharge. Median discharge bio‐ADM was 33.7 [21.5–61.5] pg/mL. Patients with higher discharge bio‐ADM levels were hospitalised longer, had higher brain natriuretic peptide levels, and poorer diuretic response (all P &lt; 0.001). Bio‐ADM was the strongest predictor of discharge residual congestion (clinical congestion score &gt; 3) (odds ratio 4.35, 95% confidence interval 3.37–5.62; P &lt; 0.001). Oedema at discharge was one of the strongest predictors of discharge bio‐ADM (β = 0.218; P &lt; 0.001). Higher discharge loop diuretic doses were associated with a poorer diuretic response during hospitalisation (β = 0.187; P &lt; 0.001) and higher bio‐ADM levels (β = 0.084; P = 0.020). High discharge bio‐ADM levels combined with higher use of loop diuretics were independently associated with a greater risk of 60‐day HF rehospitalisation (hazard ratio 4.02, 95% confidence interval 2.23–7.26; P &lt; 0.001). Conclusion In hospitalised HF patients, elevated pre‐discharge bio‐ADM levels were associated with higher discharge loop diuretic doses and reflected residual congestion. Patients with combined higher bio‐ADM levels and higher loop diuretic use at discharge had an increased risk of rehospitalisation. Assessment of discharge bio‐ADM levels may be a readily applicable marker to identify patients with residual congestion at higher risk of early hospital readmission.
A Polymorphic Oncofetal Antigen Recognized by CD8+ CTL from Two Patients Experiencing Regression of Metastatic Renal Cell Carcinoma after Allogeneic HCT.
Authors: Edus H. Warren, Jeffrey K. Mito, Scott S. Tykodi, John A. Thompson, Brenda M. Sandmaier, Rainer Storb, Stanley R. Riddell, Benoît Van den Eynde
Journal: Blood (2005)
NFATc3-dependent expression of miR-153-3p promotes mitochondrial fragmentation in cardiac hypertrophy by impairing mitofusin-1 expression
Authors: Tao Wang, Mei Zhai, Sheng Xu, Murugavel Ponnusamy, Yan Huang, Cui-Yun Liu, Man Wang, Chan Shan, Pei-Pei Shan, Xiang-Qian Gao, Kai Wang, Xin-Zhe Chen, Jing Liu, Jing-Yi Xie, De-Yu Zhang, Lu-yu Zhou, Kun Wang
Journal: Theranostics (2019)

Mitochondrial dysfunction is involved in the pathogenesis of various cardiovascular disorders. Although mitochondrial dynamics, including changes in mitochondrial fission and fusion, have been implicated in the development of cardiac hypertrophy, the underlying molecular mechanisms remain mostly unknown. Here, we show that NFATc3, miR-153-3p, and mitofusion-1 (Mfn1) constitute a signaling axis that mediates mitochondrial fragmentation and cardiomyocyte hypertrophy. Methods: Isoprenaline (ISO) was used to stimulate the hypertrophic response and mitochondrial fragmentation in cultured cardiomyocytes and in vivo. We performed immunoblotting, immunofluorescence, and quantitative real-time PCR to validate the function of Mfn1 in cardiomyocyte hypertrophy. Bioinformatic analyses, a luciferase reporter assay, and gain- and loss-of-function studies were used to demonstrate the biological function of miR-153-3p, which regulates mitochondrial fragmentation and hypertrophy by targeting Mfn1. Moreover, ChIP-qPCR and a luciferase reporter assay were performed to identify transcription factor NFATc3 as an upstream regulator to control the expression of miR-153-3p. Results: Our results show that ISO promoted mitochondrial fission and enhanced the expression of miR-153-3p in cardiomyocytes. Knockdown of miR-153-3p attenuated ISO-induced mitochondrial fission and hypertrophy in cultured primary cardiomyocytes. miR-153-3p suppression inhibited mitochondrial fragmentation in ISO-induced cardiac hypertrophy in a mouse model. We identified direct targeting of Mfn1, a key protein of the mitochondrial fusion process, by miR-153-3p. Also, miR-153-3p promoted ISO-induced mitochondrial fission by suppressing the translation of Mfn1. We further found that NFATc3 activated miR-153-3p expression. Knockdown of NFATc3 inhibited miR-153-3p expression and blocked mitochondrial fission and hypertrophic response in cardiomyocytes. Conclusions: Our data revealed a novel signaling pathway, involving NFATc3, miR-153-3p, and Mfn1, which could be a therapeutic target for the prevention and treatment of cardiac hypertrophy.
Abstract 11553: Decreasing Mortality of Ventricular Assist Devices at Children's Hospitals from 2000 to 2010: Improvement at a Cost
Authors: Joseph W Rossano, Antonio R Mott, Zeinab Mohamad, Xianqun Luan, Kimberly Y Lin, Beth D Kaufman, Chitra Ravishankar, J W Gaynor, Robert E Shaddy, Theoklis Zaoutis
Journal: Circulation (2012)

Introduction: The use of ventricular assist devices (VADs) has increased dramatically in adult heart failure patients. However, the overall use, outcome, and resource utilization of VADs in pediatr...
Chromosomal Imbalances in Germinal Center B-Cell-Like and Activated B-Cell-Like Diffuse Large B-Cell Lymphoma Influence Gene Expression Signatures and Improve Gene Expression-Based Survival Prediction(the First Two Authors Contributed Equally to This Work).
Authors: Andreas Zettl, Silvia Bea, George Wright, Itziar Salaverria, Philipp Jehn, German Ott, Wing-Chung Chan, Elaine Jaffe, Dennis Weisenburger, Timothy Greiner, James Armitage, Randy Gascoyne, Joseph Connors, Thomas Grogan, Thomas Miller, Richard Fisher, Jan Delabie, Stein Kvaloy, Hans Konrad Mueller-Hermelink, Christof Burek, Victor Moreno, Emilio Montserrat, Wyndham Wilson, Louis Staudt, Andreas Rosenwald, Elias Campo
Journal: Blood (2004)
The Combination of 2-CDA and Rituximab in Patients with Chronic Lymphocytic Leukemia (CLL): A Prospective Multicenter Phase II Trial (SAKK 34/02).
Authors: Nicolas Leupin, Jan C. Schuller, Max Solenthaler, Andre Tichelli, Alois Gratwohl, Kurt Beretta, Mario J. Bargetzi, Andreas Himmelmann, Susanne Hanselmann, Reinhard Zenhausern
Journal: Blood (2007)
Keratin 18 Is a Diagnostic and Prognostic Factor for Acute Alcoholic Hepatitis
Authors: Vatsalya Vatsalya, Matthew C. Cave, Maiying Kong, Leila Gobejishvili, K. Cameron Falkner, John Craycroft, Mack Mitchell, Gyongi Szabo, Arthur McCullough, Srinivasan Dasarathy, Svetlana Radaeva, Bruce Barton, Craig J. McClain
Journal: Clinical Gastroenterology and Hepatology (2019)
Assessment of mitral valve regurgitation by cardiovascular magnetic resonance imaging
Authors: Pankaj Garg, Andrew J. Swift, Liang Zhong, Carl-Johan Carlhäll, Tino Ebbers, Jos Westenberg, Michael D. Hope, Chiara Bucciarelli-Ducci, Jeroen J. Bax, Saul G. Myerson
Journal: Nature Reviews Cardiology (2019)

Abstract Mitral regurgitation (MR) is a common valvular heart disease and is the second most frequent indication for heart valve surgery in Western countries. Echocardiography is the recommended first-line test for the assessment of valvular heart disease, but cardiovascular magnetic resonance imaging (CMR) provides complementary information, especially for assessing MR severity and to plan the timing of intervention. As new CMR techniques for the assessment of MR have arisen, standardizing CMR protocols for research and clinical studies has become important in order to optimize diagnostic utility and support the wider use of CMR for the clinical assessment of MR. In this Consensus Statement, we provide a detailed description of the current evidence on the use of CMR for MR assessment, highlight its current clinical utility, and recommend a standardized CMR protocol and report for MR assessment.
Onset conditions for psychological and psychosomatic symptoms during psychotherapy: a new theory based on a unique data set
Authors: L Luborsky
Journal: American Journal of Psychiatry (1996)

The author's goal was to evaluate theories of the conditions that exist before onset of psychological and somatic symptoms by assessing these preconditions clinically and quantitatively.He assembled a set of texts from the cases of seven patients who had recurrent psychological or somatic symptoms and examined the segments of texts that came before the symptoms occurred; he then compared these segments with segments of text that occurred before control points in the same case. The recurrent psychological symptoms were momentary forgetting, shifts in level of depression, and phobic behavior; the recurrent somatic symptoms were stomach ulcer pains, migraine headaches, absence epilepsy (petit mal) episodes, and premature ventricular contractions of the heart.1)Independent ratings of presymptom segments compared with precontrol segments revealed some significant differences in all seven cases. 2) Some variables that distinguished the presymptom from the precontrol segments occurred in all of the cases. In rank order of their effect size across cases, these variables were hopelessness, lack of control, anxiety, feeling blocked, helplessness, concern about "supplies," depression, and hostility toward the therapist. For example, hopelessness was significant in seven of the seven cases.For the first time, segments of texts of psychotherapy sessions that occurred before recurrent symptoms have been assembled and analyzed. These brief segments before recurrent symptoms showed more of certain qualities than did segments before control points where no symptoms appeared. On the basis of these results the author constructed a new symptom-context theory of symptom formation and compared this new theory with five classical theories of symptom formation, drawing implications for research and for treatment techniques.
介入心脏病学知识（三）——经皮冠状动脉介入治疗的新进展
Authors: JulianGunn, EverDGrech, DavidCrossman, DavidCumberland, 邱洪, 吴永健
Journal: BMJ (2005)

在很多国家中，经皮冠状动脉介入治疗(PCI)已经成为比冠状动脉搭桥手术(CABG)更普遍的治疗方法，其例数还在不断增加。一位介入治疗专家一天可能要治疗4～6位复杂、多支病变或急性冠脉综合征的患者。不同的球囊、支架和其他设备经外周动脉通过直径2mm的导管送入。该方法的成功率大于95％，严重并发症的发生率很低。几个小时后患者就可活动，并经常在当天或次日出院。而且目前再狭窄率也正在降低。
Competency-Based Medical Education
Authors: Benjamin J.W. Chow, Ali Alenazy, Gary Small, Andrew Crean, Yeung Yam, Rob S. Beanlands, Owen Clarkin, Michael Froeschl, Terrence D. Ruddy, Alomgir Hossain
Journal: JACC. Cardiovascular imaging (2019)

This study sought to: 1) determine if the current training volume guidelines are reasonable for attaining competence for interpreting myocardial perfusion imaging (MPI); and if not, 2) identify potential thresholds for training volumes and competence.There is a growing desire to adopt competency-based medical education (CBME). As such, the implementation of CBME will require new and novel methods of defining, measuring, and assessing clinical competence. The potential use of CBME in cardiac imaging has not been well studied.Consecutive MPI studies were interpreted independently by trainees, and expert readers reviewed the same studies. Studies were quantified using summed scores and % left ventricular (LV) ischemia and the kappa agreement between trainee and expert were measured every 50 cases. Agreement for all MPI and abnormal MPI cases was calculated.A total of 24 trainees interpreted 9,668 MPI studies over 37 months. Agreement between trainees and expert readers increased with MPI case volumes but at different rates. The threshold for competence was set at 2 SDs below expert interobserver agreement. The average trainee surpassed this threshold for both summed stress score and %LV ischemia after 800 studies and after 400 abnormal MPI studies. Trainees learned at different rates and surpassed the competence threshold after different case volumes.The use of CBME within nuclear cardiology appears to be feasible. Our results suggest that current guidelines may be insufficient to ensure competence and would support the need to increase the MPI case volumes. The use of CBME principles would suggest that trainees may achieve competence at different rates and our results suggest a shift in focus from volume-based learning toward target agreement thresholds.
Molecular and Immunological Effects of Thalidomide in Chronic Lymphocytic Leukemia.
Authors: Krzysztof Giannopoulos, Anna Dmoszynska, Malgorzata Kowal, Ewa Wasik-Szczepanek, Paulina Wlasiuk, Agnieszka Bojarska-Junak, Jacek Rolinski, Hartmut Döhner, Stephan Stilgenbauer, Lars Bullinger
Journal: Blood (2008)
Identification and Characterization of Single Nucleotide Polymorphisms (SNPs) Associated with Genetic Predisposition to Develop Therapy-Related Acute Myeloid Leukemia (t-AML).
Authors: Vicent M. Guillem, Mar Tormo, Jose Angel Martinez-Climent, Ana Lluch, Isabel Benet, Marcos Gonzalez, Josep Nomdedeu, Javier Garcia-Conde
Journal: Blood (2004)
Myeloablative, Reduced Toxicity IV Busulfan/Fludarabine (BuFlu) and Allogeneic Hematopoietic Stem Cell Transplant (HSCT) for Patients in the 6th and 7th Decades of Life with AML or MDS
Authors: Gheath Alatrash, Borje S. Andersson, Matteo Pelosini, Gabrila Rondon, Muzaffar H. Qazilbash, Sergio Giralt, Leandro de Padua Silva, Chitra Hosing, Partow Kebriaei, Weiqing Zhang, Rima Saliba, Richard E. Champlin, Marcos De Lima
Journal: Blood (2008)
Metabolic Effects of Oxytocin
Authors: Shana E McCormack, James E Blevins, Elizabeth A Lawson
Journal: Endocrine Reviews (2019)

There is growing evidence that oxytocin (OXT), a hypothalamic hormone well recognized for its effects in inducing parturition and lactation, has important metabolic effects in both sexes. The purpose of this review is to summarize the physiologic effects of OXT on metabolism and to explore its therapeutic potential for metabolic disorders. In model systems, OXT promotes weight loss by decreasing energy intake. Pair-feeding studies suggest that OXT-induced weight loss may also be partly due to increased energy expenditure and/or lipolysis. In humans, OXT appears to modulate both homeostatic and reward-driven food intake, although the observed response depends on nutrient milieu (eg, obese vs. nonobese), clinical characteristics (eg, sex), and experimental paradigm. In animal models, OXT is anabolic to muscle and bone, which is consistent with OXT-induced weight loss occurring primarily via fat loss. In some human observational studies, circulating OXT concentrations are also positively associated with lean mass and bone mineral density. The impact of exogenous OXT on human obesity is the focus of ongoing investigation. Future randomized, placebo-controlled clinical trials in humans should include rigorous, standardized, and detailed assessments of adherence, adverse effects, pharmacokinetics/pharmacodynamics, and efficacy in the diverse populations that may benefit from OXT, in particular those in whom hypothalamic OXT signaling may be abnormal or impaired (eg, individuals with Sim1 deficiency, Prader-Willi syndrome, or craniopharyngioma). Future studies will also have the opportunity to investigate the characteristics of new OXT mimetic peptides and the obligation to consider long-term effects, especially when OXT is given to children and adolescents. (Endocrine Reviews XX: XX - XX, 2020).
東アジア人進行非小細胞肺癌患者における一次治療としてのシスプラチン+ペメトレキセド療法vsシスプラチン+ゲムシタビン療法の有効性および安全性--第3相試験の探索的サブグループ解析の結果[含 コメント]
Authors: Chih-Hsin Yang, Lorinda Simms, Keunchil Park
Journal: Journal of Thoracic Oncology (2010)
Conversion to Full Donor Chimerism without Gvhd Using High-Dose DLI in Minimally Conditioned Miniature Swine Recipients of Haploidentical HCT.
Authors: Raimon Duran-Struuck, Banjamin M Horner, Bram V Lutton, Alex G.S. Teague, Kelly K. Ferguson, Jonathan C Summers, Thomas Spitzer, Jay Fishman, Stuart Houser, David H Sachs, Christene A Huang
Journal: Blood (2008)
Characterization of the Interaction Between Diferric Transferrin and Transferrin Receptor 2 by Functional Assays and Atomic Force Microscopy (AFM).
Authors: Katsuya Ikuta, Alexandre Yersin, Junko Jimbo, Takaaki Hosoki, Motohiro Shindo, Kazuya Sato, Yoshihiro Torimoto, Atsushi Ikai, Yutaka Kohgo
Journal: Blood (2008)
Abstract 3733: Platelet Serotonin Receptor Stimulation Induces Shedding of the Adhesion Molecule GPIbα
Authors: Daniel Duerschmied, Matthias Canault, Dirk Lievens, Alexander Brill, Stephen M Cifuni, Ian Patten, Michael Bader, Denisa D Wagner
Journal: Circulation (2008)

Objectives Serotonin (5-hydroxytryptamine, 5HT) is not only a neurotransmitter involved in a variety of central nervous functions, but is also a peripheral hormone that is transported by platelets....
How do the new Olympic sports compare with the traditional Olympic sports? Injury and illness at the 2018 Youth Olympic Summer Games in Buenos Aires, Argentina
Authors: Kathrin Steffen, Torbjørn Soligard, Margo Mountjoy, Ignacio Dallo, Alan Maximiliano Gessara, Hernan Giuria, Leonel Perez Alamino, Joaquin Rodriguez, Natalia Salmina, Daniel Veloz, Richard Budgett, Lars Engebretsen
Journal: British Journal of Sports Medicine (2019)

To describe injuries and illnesses across traditional and new sports among the participating athletes of the Buenos Aires 2018 Youth Olympic Summer Games (BA YOG) (6-18 October 2018).We recorded the daily number of athlete injuries and illnesses (1) through the reporting of all National Olympic Committee (NOC) medical teams and (2) in the polyclinic and medical venues manned by the BA YOG 2018 medical staff.In total, 3.984 athletes from 206 NOCs were observed. NOCs and BA YOG 2018 medical staff reported 619 injuries and 334 illnesses, equalling 15.5 injuries and 8.4 illnesses per 100 athletes over the 13-day period. The eight new sports on the Youth Olympic programme (futsal, beach handball, karate, roller speed skating, kitesurfing, BMX freestyle, climbing and break dancing) fell in between the other sports with respect to injury and illness risk. Injury incidence was highest in rugby (43% of all rugby players), followed by boxing (33%) and badminton (24%), and lowest in swimming, archery, roller speed skating, equestrian, climbing and rowing (<5%). The highest incidences of illness were recorded in golf (20%), followed by triathlon (16%), beach volleyball and diving (both 14%). Of the illnesses, 50% affected the respiratory system and 15% the gastrointestinal system. Injury and illness incidences varied between continents with athletes representing Europe having significantly fewer injuries and illnesses compared with other continents, apart from a similar illness incidence to Asian athletes.The overall injury incidence of 15.5 injuries per 100 athletes was higher, while the overall illness incidence of 8.4 illnesses per 100 athletes was similar to previous youth and Olympic Games. The new sports did not differ significantly compared with the other sports with respect to injury and illness risk.
Expert insights: The potential role of the gut microbiome‐bile acid‐brain axis in the development and progression of Alzheimer's disease and hepatic encephalopathy
Authors: Wei Jia, Cynthia Rajani, Rima Kaddurah‐Daouk, Houkai Li
Journal: Medicinal Research Reviews (2019)

Abstract Recent epidemiological and molecular studies have linked the disruption of cholesterol homeostasis to increased risk for developing Alzheimer's disease (AD). Emerging evidence also suggests that brain cholesterol accumulation contributes to the progression of hepatic encephalopathy (HE) via bile acid (BA)‐mediated effects on the farnesoid X receptor. In this perspective paper, we reviewed several recently published studies that suggested a role for the gut microbiota transformation of BAs as a factor in AD and HE development/progression. We hypothesize that in addition to cholesterol elimination pathways, alteration of the gut microbiota and subsequent changes in both the serum and brain BA profiles are mechanistically involved in the development of both AD and HE, and thus, are a potential target for the prevention and treatment of the two diseases. Our understanding of the microbiome‐BAs‐brain axis in central nervous system disease is still evolving, and critical questions regarding the emerging links among central, peripheral, and intestinal metabolic failures contributing to brain health and disease during aging have yet to be addressed.
A Critical Analysis of Prognostic Factors in Patients with HTLV-1 Adult T-Cell Leukemia/Lymphoma: A Multicenter Clinicopathologic Experience and New Prognostic Score.
Authors: Adrienne A. Phillips, Iuliana Shapira, Robert D. Willum, Jasotha Sanmugarajah, William B. Solomon, Steven M. Horwitz, David G. Savage, Govind Bhagat, Gerald Soff, Jasmine M. Zain, Bashir Alobeid, Venkatraman E. Seshan, Owen A. O’Connor
Journal: Blood (2008)
Clinical Considerations Prior to Transition From Triple Antithrombotic Therapy to Dual Antithrombotic Therapy
Authors: Elisabeth M. Sulaica, Matthew A. Wanat, Tracy E. Macaulay
Journal: JAMA Cardiology (2019)

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HLA-Matched Related (MRD) or Unrelated Donor (URD) Non-Myeloablative Hematopoietic Cell Transplantation (HCT) for Patients (pts) with Refractory and Relapsed Aggressive Non Hodgkin Lymphoma (NHL).
Authors: L. Norasetthada, M. B. Maris, B. M. Sandmaier, T. Gooley, S. Forman, E. Agura, R. T. Maziarz, J. Shizuru, D. Niederwieser, R. Storb, D. G. Maloney
Journal: Blood (2004)
Racial Disparities in Route of Hysterectomy for Benign Indications Within an Integrated Health Care System
Authors: Eve Zaritsky, Anthonia Ojo, Lue-Yen Tucker, Tina R. Raine-Bennett
Journal: JAMA Network Open (2019)

to system changes. 4,5Our initiative increased MIH rates and the proportion of high-volume surgeons while simultaneously reducing the surgeon pool.With these system changes, we observed a reduction of racial disparities in MIH.
Mutations in TERT, the Gene Encoding Telomerase Reverse Transcriptase, in “Acquired” Aplastic Anemia Inhibit Enzymatic Function by a Dominant Negative Mechanism of Action.
Authors: Rodrigo T. Calado, Hinh Ly, Hiroki Yamaguchi, Gabriela M. Baerlocher, Sachiko Kajigaya, Stephen J. Chanock, Peter M. Lansdorp, Neal S. Young
Journal: Blood (2004)
A Novel Fusion between ETV6 and NCOA2 Defines a New Entity of Acute Leukemia with Co-Expression of T-Cell and Myeloid Markers.
Authors: Sabine Strehl, Karin Nebral, Margit König, Jochen Harbott, Bella Bielorai, Stephanie Struski, Shai Izraeli, Oskar A. Haas
Journal: Blood (2006)