tbuckley/cabot-search huggingface dataset:
AORTIC DISTENSIBILITY BY MAGNETIC RESONANCE IMAGING INVERSELY ASSOCIATES WITH NON-CALCIFIED CORONARY PLAQUE BURDEN BY CORONARY CT ANGIOGRAPHY IN PSORIASIS
Authors: Parag Shukla, Amit Dey, Youssef Elnabawi, Harry Choi, Jacob Groenendyk, Milena Aksentijevich, Noor Khalil, Jenis Argueta-Amaya, Aarthi Reddy, Justin Rodante, Martin Playford, Mohammad Naqi, Julie Erb-Alvarez, Mark Ahlman, Veit Sandfort, Marcus Chen, David Bluemke, Joel Gelfand, Nehal Mehta
Journal: Journal of the American College of Cardiology (2019)
BASELINE GLOBAL LONGITUDINAL STRAIN BY COMPUTED TOMOGRAPHY IS ASSOCIATED WITH ALL-CAUSE MORTALITY IN PATIENTS RECEIVING TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Miho Fukui, Floyd Thoma, Ibrahim Sultan, Suresh Mulukutla, Hesham Elzomor, Joon Lee, John Schindler, Thomas Gleason, Joao L. Cavalcante
Journal: Journal of the American College of Cardiology (2019)
FACTORS DETERMINING AORTIC VALVE DYSFUNCTION IN PATIENT WITH A NORMAL FUNCTIONING BICUSPID AORTIC VALVE
Authors: William K.F. Kong, Elise Vollema, Francesca Prevedello, Kian Keong Poh, Rebecca Perry, Miriam Shanks, Bogdan Popescu, Michael Liang, Wei Xian Chen, Nina Marsan, Fausto Pinto, Philippe Pibarot, Arturo Evangelista-Masip, Marcin Fijalkowski, Jose Zamorano, Joseph Selvanayagam, Victoria Delgado, Jeroen J. Bax
Journal: Journal of the American College of Cardiology (2019)
A Record Year for Device Approvals
Authors: Rebecca Voelker
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract MP054: Associations of Monounsaturated Fat From Plant and Animal Sources With Coronary Heart Disease Risk
Authors: Geng Zong, Yanping Li, Anne Wanders, Peter Zock, Laura Sampson, Walter Willett, Frank Hu, Qi Sun
Journal: Circulation (2017)

Background: The association between monounsaturated fat (MUFA) intake and coronary heart disease (CHD) risk remains unclear. We aimed to investigate whether MUFA from plant foods (MUFA-P) and animal foods (MUFA-A) show different associations with CHD risk in two large prospective studies of U.S. men and women. Method: We calculated MUFA-P and MUFA-A among 60,931 women in the Nurses’ Health Study (1990-2012), and 28,445 men in the Health Professionals Follow-Up Study (1990-2010). Diet was assessed by validated food-frequency questionnaire every 4 years. CHD incidence was self-reported and confirmed by review of medical records or death certificates. Result: MUFA-A (median intake: 5.8-6.1% energy) was highly correlated with saturated fat (SFA; spearman correlation [ r ] =0.81-0.83) but not polyunsaturated fat (PUFA, r =0.04 -0.19), whereas MUFA-P intake (median: 5.3-5.4.9% energy) was strongly correlated with PUFA(r=0.61 for both cohorts) but not SFA ( r =0.20-0.21; All P&lt;0.001). In multivariate models adjusted for demographic, lifestyle, and dietary factors, hazard ratios of CHD (HR, 95% confidence interval[95%CI]) from low to high total MUFA quintiles were 1 (reference), 0.92 (0.83, 1.02), 1.03 (0.93, 1.05), 0.89 (0.79,1.00). 0.95(0.873, 1.08; P trend =0.42). For MUFA P these were 1(reference), 0.98 (0.89, 1.07), 0.90 (0.82, 0.99), 0.85 (0.77, 0.93), and 0.86 (0.78, 0.94; P trend &lt;0.001) and for MUFA-A 1(reference), 1.09 (0.99, 1.20), 1.22 (1.11, 1.35), 1.26 (1.13, 1.39), and 1.33 (1.19, 1.48; P trend &lt;0.001). In the energy-density model, CHD risk was lower when MUFA-P iso-calorically replaced 1% energy from total SFA (HR [95%CI]: 0.96[0.92, 1.00]; P=0.03), with no significant changes when MUFA-A replacing SFA (HR [95%CI]: 1.01[0.95, 1.07]; P=0.76). When grouping fat intake as the sum of animal MUFA plus saturated fat and the sum of plant MUFA plus PUFA, the HR (95%CI) of CHD was 0.96 (0.95, 0.98; P&lt;0.001) for replacing 1% energy from the former with the latter. Conclusion: Because MUFA compositions of animal and plant origins are largely similar, our data suggested other components in plant and animal foods may lead to the observed different associations of MUFA-P and MUFA-A with CHD risk. These findings provided a possible explanation on current controversies regarding MUFA intake and CHD risk, and further support health benefit of MUFA intake.
Abstract 528: Cell Specific Signaling Regulated by PI3Kγ Modulates Myofibroblast Differentiation
Authors: Maradumane L Mohan, Lisa M Grove, Robert S Papay, Mitchell A Olman, Sathyamangla V Naga Prasad
Journal: Circulation Research (2018)

Phosphoinositide 3 Kinase γ (PI3Kγ) regulates anti-apoptotic Akt signaling. Previous studies have established a role for PI3Kγ in cardiac fibrosis, a key underlying cause of heart failure. However, less is known about the mechanism by which PI3Kγ regulates cardiac myofibroblast differentiation, hallmark of tissue fibrosis, characterized by smooth muscle α-actin (αSMA) overexpression. Measurement of αSMA abundance in cardiac lysates from PI3Kγ null mice (PI3Kγ -/- ) showed significant baseline and pressure overload induced upregulation compared to wildtype (WT), indicating that loss of PI3Kγ predisposes the hearts towards fibrosis. Furthermore, isolated cardiac fibroblasts (CF) from PI3Kγ -/- exhibited a myofibroblast phenotype with αSMA in stress fibers. Correspondingly, immunoblotting showed significantly higher αSMA in PI3Kγ -/- CF than WT. It has been previously shown that fibroblast growth factor mediated activation of the signaling pathway downregulates αSMA and that this inhibition of αSMA expression is through negative regulation by extracellular regulated kinase (ERK). To understand whether PI3Kγ regulates ERK signaling in a cell specific manner and thereby possibly αSMA, the phosphorylation of ERK by insulin stimulation were compared in CF isolated from WT and PI3Kγ -/- . Intriguingly, there was significant loss of ERK phosphorylation in CF from PI3Kγ -/- when compared to CF from WT. However, ERK phosphorylation was not altered in cardiomyocytes (CM) due to the absence of PI3Kγ. Confirming this differential regulation of ERK in CM and CF, there was no change in the association of ERK and protein phosphatase 2A (PP2A) in CM of WT and PI3Kγ -/- . However, there was increased association of PP2A with ERK in CF of PI3Kγ -/- when compared to CF from WT. This is because in the CM, ERK is regulated by Dual Specificity Phosphatase (DUSP8). However, in the CF, PP2A is the major regulator of ERK and thus PI3Kγ plays a major role in ERK signaling in CF. Consistent with previous observations, we found that association of DUSP8 with ERK was not observed in CF. Moreover, ERK-DUSP8 interaction was not dependent on the presence or absence of PI3Kγ. These data indicate that PI3Kγ regulates signaling pathways in a cell specific manner with respect to cardiac remodeling.
Abstract 534: Modulatory Effect of Nkx2.5+ Cardiomyoblast Secreted Exosomes in Cardiometabolism
Authors: Wen-Pin Chen, Wei-Ping Lian, Min-Yi You, You-Yi Li
Journal: Circulation Research (2018)

It was found cardiac precursors secreted exosomes (CPC-exo) may have anti-apoptotic and anti-fibrotic actions to facilitate cardiac repair in the damaged hearts. It remains unclear the effect of CPC-exo in cardiometabolism. The aim of the study was to assess the modulatory action of CPC-exo in cardiometabolism of cardiomyopathic cardiomyocytes. Nkx2.5+ cardiomyoblasts were enzymatically isolated and were purified by FACS sorter from mouse embryonic stem cells under cardiomyogenic differentiation or transgenic mice hearts (2 weeks old) carrying GFP reporter driven by Nkx2.5-enhancer for the purification of the exosomes (mESC-Nkx2.5+exo and postnatal-Nkx2.5+exo) from the culture medium by ExoQuick-TC. The vesicle size was further measured by Nanosight. The exosomal miRNA profile was characterized by miRNA microarray. It was further compared the different effect of mESC-Nkx2.5+exo and postnatal-Nkx2.5+exo in the mitochondrial function of human cardiomyocytes derived from iPSC of left ventricle non compaction (LVNC) patients (LVNC-hiPSC-CM) by Agilent seahorse XF24 analyzer. Cell shortening was measured by Ionoptix system. It was found the defect of cardiac mitochondrial function associated with the weak cell shortening in LVNC-hiPSC-CM on day 70 after differentiation. With the treatment of mESC-Nkx2.5+exo and postnatal-Nkx2.5+exo during day 50-70, the mitochondrial function and cell shortening of LVNC-hiPSC-CM were significantly improved on day 70. The functional exosomal miRNAs were characterized in advance in this study. In conclusion, CPC-exo may exert the benefit in the improvement of cardiometabolism in cardiomyopathic cardiomyocytes.
HYPOTENSIVE RESPONSE DURING DOBUTAMINE STRESS ECHOCARDIOGRAPHY IN PATIENTS UNDERGOING ORTHOTOPIC LIVER TRANSPLANTATION IS PREDICTIVE OF LONG-TERM MORTALITY
Authors: Kajal Shah, Ahmad Alkhalil, Joe Dzierzawiec, Neil Nadpara, Richard Hajjar, Shervin Golbari, Shashank Jain, Christine Gerula, Julius Gardin, Marc Klapholz
Journal: Journal of the American College of Cardiology (2019)
SHORT TERM READMISSIONS AFTER PERCUTANEOUS CORONARY INTERVENTION: INSIGHTS FROM THE NATIONWIDE READMISSION DATABASE OVER A PERIOD OF 5 YEARS
Authors: Varunsiri Atti, Nikhil Nalluri, Byomesh Tripathi, Varun Kumar, Nileshkumar Patel, Mark Terence Mujer, Srikanth Yandrapalli, Vikramaditya Samala Venkata, Varinder Singh, Michael Kim
Journal: Journal of the American College of Cardiology (2019)
Implications of Oxalate as a Novel Risk Factor for Chronic Kidney Disease
Authors: Joachim H. Ix
Journal: JAMA Internal Medicine (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
GENOME-WIDE ASSOCIATION STUDY OF MORTALITY BENEFIT FROM BETA-BLOCKERS IN PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION
Authors: Tyler Shugg, Jia Li, Ruicong She, Hongsheng Gui, Hani N. Sabbah, L. Keoki Williams, Jasmine A. Luzum, David E. Lanfear
Journal: Journal of the American College of Cardiology (2019)
INTERVENTIONAL CARDIOLOGIST POINT OF CARE TREATMENT DECISION VERSUS VIRTUAL HEART TEAM RETROSPECTIVE EVALUATION OF MULTIVESSEL CORONARY ARTERY DISEASE: DIFFERENCES OF OPINION
Authors: Michael Tsang, Jon-David Schwalm, Matthew Sibbald, Matthew Mercuri, Sumeet Gandhi, Nandini Gupta, Andre Lamy, Adel Dyub, Bobby Yanagawa, Amiram Gafni, Daniel Pericak, Adnan Hameed, Ryan McGreal, Amin Mulji, Kostas Ioannou, Madhu Natarajan
Journal: Journal of the American College of Cardiology (2019)
COMPARISON OF JNJ9375, A THROMBIN EXOSITE 1-DIRECTED ANTIBODY, WITH APIXABAN FOR THROMBOPROPHYLAXIS AFTER ELECTIVE KNEE REPLACEMENT SURGERY: TEXT-TKR STUDY
Authors: Jeffrey I. Weitz, Gary Raskob, Michael Rud Lassen, Annelise Segers, Charles Francis, Robin Roberts, Takeshi Fuji, Gary Peters, Renee Swaim, Maureen Johnson, Juliane Bernholz, Michael Lee, John Strony
Journal: Journal of the American College of Cardiology (2019)
Cellulose nanocrystals modulate alveolar macrophage phenotype and phagocytic function
Authors: Johanna Samulin Erdem, Mayes Alswady-Hoff, Torunn K. Ervik, Øivind Skare, Dag G. Ellingsen, Shanbeh Zienolddiny
Journal: Biomaterials (2019)

Nanocellulose is a promising bio-nanomaterial with attractive properties suitable for multiple industrial applications. The increased use of nanocellulose may lead to occupational exposure and negative health outcomes. However, knowledge on its health effects is limited, and while nanocellulose exposure may induce acute inflammatory responses in the lung, the underlying mechanisms are unknown. Alveolar macrophages are key cells in alveolar particle clearance. Their activation and function may be affected by various particles. Here, we investigated the uptake of pristine cellulose nanocrystals (CNC), and their effects on alveolar macrophage polarization and biological function. CNC uptake enhanced the secretion of several cytokines but did not on its own induce a complete macrophage polarization. In presence of macrophage activators, such as LPS/IFNG and IL4/IL13, CNC exposure enhanced the expression of M1 phenotype markers and the secretion of pro-inflammatory cytokines and chemokines, while decreasing M2 markers. CNC exposure also affected the function of activated alveolar macrophages resulting in a prominent cytokine burst and altered phagocytic activity. In conclusion, CNC exposure may result in dysregulation of macrophage activation and function that are critical in inflammatory responses in the lung.
Interest of Dosing of Ibrutinib in B-Cell Lymphoid Malignancies: Data from a Real-Life, Phase 4 Study
Authors: Anne Calleja, Sandra De Barros, Camille Vinson, Caroline Protin, Lucie Oberic, Fanny Gallais, Melanie White-koning, Etienne Chatelut, Christian Recher, Sarah Cadot, Anne Quillet Mary, Loic Ysebaert, Fabien Despas
Journal: Blood (2018)
PROGNOSTIC UTILITY OF DIASTOLIC DYSFUNCTION AND SPECKLE TRACKING IN PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION
Authors: Sune Bengtsen Holm Hansen, Philip Brainin, Morten Sengeløv, Peter Jørgensen, Niels Eske Bruun, Flemming Javier Olsen, Thomas Hansen, Morten Schou, Gunnar Gislason, Tor Biering-Sorensen
Journal: Journal of the American College of Cardiology (2019)
Impaired control of multiple viral infections in a family with complete IRF9 deficiency
Authors: María Bravo García-Morato, Ane Calvo Apalategi, Luz Yadira Bravo-Gallego, Alfonso Blázquez Moreno, Miriam Simón-Fuentes, Jenny V. Garmendia, Ana Méndez Echevarría, Teresa del Rosal Rabes, Ángeles Domínguez-Soto, Eduardo López-Granados, Hugh T. Reyburn, Rebeca Rodríguez Pena
Journal: Journal of Allergy and Clinical Immunology (2019)
PEDIATRIC CARDIAC CRITICAL CARE OUTCOMES IMPROVE FOLLOWING IMPLEMENTATION OF A COMMERCIAL DATA AGGREGATION AND VISUALIZATION SOFTWARE PLATFORM
Authors: Michael Gaies, Mary K. Olive, Gabe Owens, John Charpie, Wenying Zhang, Sara Pasquali, Darren Klugman, John Costello, James Hammel, J. William Gaynor, Mousumi Banerjee, Steven Schwartz
Journal: Journal of the American College of Cardiology (2019)
ASSOCIATION OF BODY MASS INDEX WITH ABLATION SUCCESS AND COMORBIDITIES IN PATIENTS WITH ATRIAL FIBRILLATION
Authors: Sanghamitra Mohanty, Chintan Trivedi, Domenico Della Rocca, Qiong Chen, Omer Gedikli, Carola Gianni, Alfredo C. Tapia, Sharan Sharma, John Burkhardt, Javier Sanchez, Gerald Gallinghouse, Amin Al-Ahmad, Rodney Horton, Dhanunjaya Lakkireddy, Andrea Natale
Journal: Journal of the American College of Cardiology (2019)
Abstract P5-14-03: Patient perspectives on HER2+ breast cancer recurrence: Results from an online patient survey
Authors: M Jenkins
Journal: Cancer Research (2019)

Abstract Background: The objective of this study was to gather insights from patients with early-stage HER2+ breast cancer regarding fears and knowledge of breast cancer recurrence and approaches to reducing risk of recurrence. Methods: From Nov. 7-30, 2017, patients with stage I-IIIC HER2+ breast cancer were recruited via postings to Breastcancer.org discussion boards to participate in an online survey comprising 17 questions designed to quantify fears and emotions related to recurrence, identify and characterize knowledge gaps, and understand what patients are willing to tolerate to reduce recurrence risk. Results: Of 307 respondents, 87% were aged ≥40 years and over half were ≥50 (58%). The majority had completed (48%) or were undergoing (39%) postsurgical treatment. Recurrence was a concern for 93% of patients and was the highest rated concern for 78%; however, most patients (76%) perceived their personal risk of recurrence to be moderate or low. 59% of patients felt they were at least somewhat informed about risk of recurrence; 55% had discussed risk of recurrence with their health care team, with discussions most frequently initiated by the patient (56%) vs the health care team (40%). Oncologists were the primary source of information about risk of recurrence (58%), but patients also frequently sourced information from online content (29%), published research (18%), and Breastcancer.org (15%). Almost all (96%) patients were at least somewhat involved in treatment planning. While 55% of patients would inquire about a new drug if it conferred a 10%-20% reduction in risk of recurrence, 26% required a benefit of ≥50%. For treatments reducing the risk of recurrence, patients were willing to tolerate (in order from most to least willing) hot flashes, fatigue, diarrhea, joint pain, and nausea/vomiting. Conclusions: While patients with HER2+ breast cancer are highly concerned about recurrence, most feel that their personal risk is moderate. Patients are highly engaged in treatment planning, often initiate discussions about risk of recurrence, and supplement their knowledge with their own research. The threshold to motivate inquiry into a new drug to reduce recurrence risk was &amp;lt;20% for over half of patients. Patients were also frequently willing to tolerate common adverse events. Citation Format: Jenkins M. Patient perspectives on HER2+ breast cancer recurrence: Results from an online patient survey [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr P5-14-03.
Abstract 17272: Lost in Translation: New Cardiomyopathy in a 49-Year-Old Spanish-Speaking Man With Systemic Lupus Erythematosus and Lupus Nephritis
Authors: Emily Lau, Rahul Sakhuja, James Januzzi
Journal: Circulation (2017)

A 49-year-old Spanish-speaking man with systemic lupus erythematosus, lupus nephritis on hemodialysis, and antiphospholipid antibody syndrome presented with persistent sinus tachycardia and dyspnea...
PRE- AND POST-TREATMENT WITH AMIODARONE FOR ELECTIVE ELECTRICAL CARDIOVERSION OF ATRIAL FIBRILLATION: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Kevin Um, Jeff Healey, William McIntyre, Pablo A. Mendoza, Alex Koziarz, Guy Amit, Victor A. Chu, Richard Whitlock, Emilie Belley-Cote
Journal: Journal of the American College of Cardiology (2019)
PROGNOSTIC IMPLICATIONS OF BASELINE AND FOLLOW-UP CARDIOVASCULAR PHYSICAL EXAMS IN A CONTEMPORARY TRIAL OF PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION: PARADIGM-HF
Authors: Senthil Selvaraj, Brian Claggett, Andrea Pozzi, John J.V. McMurray, Pardeep Jhund, Milton Packer, Akshay S. Desai, Eldrin F. Lewis, Martin Lefkowitz, Jean L. Rouleau, Victor Shi, Michael R. Zile, Karl Swedberg, Scott D. Solomon
Journal: Journal of the American College of Cardiology (2019)
IMPORTANCE OF STABILIZED MYOCARDIAL SUBSTRATE FOR ABLATION OF VENTRICULAR TACHYCARDIA IN AN UNSTABLE ACUTELY POST-INFARCT PATIENT WITH A DURABLE LEFT VENTRICULAR ASSIST DEVICE
Authors: Gordon Ho, Andrew Lin, Jonathan Hsu, Kurt Hoffmayer, Farshad Raissi, Gregory Feld, Eric Adler, Victor Pretorius, David Krummen
Journal: Journal of the American College of Cardiology (2019)
Phase I dose-escalation study of chiauranib, a novel angiogenic, mitotic, and chronic inflammation inhibitor, in patients with advanced solid tumors
Authors: Yongkun Sun, Lin Yang, Xuezhi Hao, Yutao Liu, Jinwen Zhang, Zhiqiang Ning, Yuankai Shi
Journal: Journal of Hematology & Oncology (2019)

Chiauranib is a novel orally active multi-target inhibitor that simultaneously inhibits the angiogenesis-related kinases (VEGFR2, VEGFR1, VEGFR3, PDGFRα, and c-Kit), mitosis-related kinase Aurora B, and chronic inflammation-related kinase CSF-1R. This phase I dose-escalation study was to determine the maximum tolerated dose (MTD), safety, pharmacokinetics, and preliminary antitumor activity of chiauranib in patients with refractory advanced solid tumor and lymphoma. Eighteen patients were treated with continuous dosing of chiauranib from 10 to 65 mg once daily in a dose-escalation 3 + 3 design and evaluated in 28-day cycles. Pharmacokinetic profile of plasma chiauranib was analyzed in both single and multiple dose studies. Dose-limiting toxicity (DLT) as of grade 3 hypertension occurred in two patients at 65 mg/day, and one dose level below as MTD was 50 mg/day. The most common treatment-related adverse events included fatigue (61.1%), proteinuria (44.4%), hematuria (38.9%), hypothyroidism (38.9%), hypertriglyceridemia (33.3%), and hypertension (33.3%). A linear and dose-dependent pharmacokinetic profile of chiauranib was characterized with rapid absorption and slow elimination feature in both single and multiple dose studies. The accumulative exposure of chiauranib reached the steady state within 8 days and was approximately increased by twofold as those in the single dose study. No complete or partial response was observed, and 12 patients (66.7%) achieved stable disease (SD). Chiauranib demonstrated an acceptable safety and favorable pharmacokinetic profile with potential antitumor activity. Several phase Ib/II clinical studies are currently under further investigation. NCT, NCT02122809 . Registered 25 April 2014
CARDIOVASCULAR EVENTS IN PATIENTS RECEIVING SULODEXIDE VERSUS CONTROL: SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
Authors: Behnood Bikdeli, Saurav Chatterjee, Ajay Kirtane, Sahil Parikh, Giuseppe Andreozzi, C. Michael Gibson, Samuel Goldhaber, John Eikelboom, Harlan M. Krumholz, Gregg Stone
Journal: Journal of the American College of Cardiology (2019)
NATURAL HISTORY OF CORONARY PLAQUE PROGRESSION BY QUANTITATIVE ASSESSMENT OF COMPUTED TOMOGRAPHY CORONARY ANGIOGRAPHY IN ASYMPTOMATIC PATIENTS WITH TYPE 2 DIABETES MELLITUS
Authors: Tetsu Tanaka, Satoru Kishi, Kai Ninomiya, Keita Koseki, Yu Sato, Taishi Okuno, Kei Sato, Hideki Koike, Kazuyuki Yahagi, Jun Tanaka, Kota Komiyama, Jiro Aoki, Akihiro Isogawa, Kengo Tanabe
Journal: Journal of the American College of Cardiology (2019)
HEALTH CARE RESOURCE UTILIZATION AND EXPENDITURES AMONG NEWLY DIAGNOSED NON-VALVULAR ATRIAL FIBRILLATION PATIENTS INITIATING ORAL ANTI-COAGULANTS: RESULTS FROM 100% MEDICARE 2010-2015 DATA
Authors: Ritam Chowdhury, Jessica Franchino-Elder, Li Wang, Huseyin Yuce, Cheng Wang
Journal: Journal of the American College of Cardiology (2019)