tbuckley/cabot-search huggingface dataset:
Validation of Imaging Measures in Chronic Obstructive Pulmonary Disease
Authors: Carrie Pistenmaa Aaron, George R. Washko
Journal: American Journal of Respiratory and Critical Care Medicine (2019)

with asthma (14, 15).These findings are pivotal, particularly in the light of sustaining discussions with regard to the role of ambient NO 2 concentrations on population health.It emphasizes the need to have strategies that not only reduce exhaust particulate but also scavenge NO 2 , particularly within congested urban areas, where diesel vehicles make up a significant proportion of the fleet.
Abstract 1998: Noninvasive Evaluation of Tissue Characteristics of Left Atrium with Atrial Fibrillation by Using Three Dimensional Integrated Backscatter Transesophageal Echography (IB-TEE)
Authors: Tomoki Kubota, Masanori Kawasaki, Urara Mori, Yoshiyuki Ishihara, Munenori Okubo, Takahiko Yamaki, Shinsuke Ojio, Kunihiko Tsuchiya, Kazuhiko Nishigaki, Masanao Saio, Tsuyoshi Takami, Shinya Minatoguchi, Hisayoshi Fujiwara
Journal: Circulation (2006)

Background: It is recognized that one of the causes of atrial fibrillation (AF) is pathological degeneration of the left atrium (LA). However, there has not been an appropriate noninvasive method t...
SEX DIFFERENCE IN EFFICACY AND SAFETY OF DIRECT ORAL ANTICOAGULANTS IN ASIAN PATIENTS WITH NONVALVULAR ATRIAL FIBRILLATION: 1-YEAR REAL-WORLD DATA FROM THE DIRECT REGISTRY
Authors: Nanao Matsusaki, Yohei Sotomi, Akio Hirata, Atsushi Hirayama, Yoshiharu Higuchi
Journal: Journal of the American College of Cardiology (2019)
Abstract 12442: Hs-CRP Level Represents the Disease Burden and the Age but Not Vulnerability of Coronary Atherosclerosis: A Study of Volumetric Plaque Composition by 3-vessel Virtual Histology-intravascular Ultrasound
Authors: Se Jun Park, So Yeon Choi, Jin Sun Park, Hyoung Mo Yang, Hong Seok Lim, Byoung Joo Choi, Joon Han Shin, Seung Jea Tahk
Journal: Circulation (2013)

Background: hs-CRP has been known as a systemic inflammatory marker of atherosclerosis and considered as one of the predictors of future cardiac events. Some reports presented hs-CRP level was asso...
EVALUATION OF CHEST PAIN IN THE EMERGENCY DEPARTMENT: REAL WORLD COMPARISON BETWEEN ANATOMICAL AND FUNCTIONAL IMAGING MODALITIES
Authors: Faraj Kargoli, Harjit Chahal, Nurilign Bulcha, Durline Brown-Manhertz, Andrea Furlani, Dalvert Polanco, Anjani Golive, Pedro Villablanca, Abdulaziz H. Al-Bunnia, Ari Friedman, Mohammed Makkiya, Waddy Gonzalez, Cynthia Taub, Mario Garcia
Journal: Journal of the American College of Cardiology (2019)
CLINICAL AND NEURODEVELOPMENTAL OUTCOMES IN SINGLE VENTRICLE PATIENTS RECEIVING EXTRACORPOREAL MEMBRANE OXYGENATION: AN ANALYSIS OF THE PEDIATRIC HEART NETWORK SINGLE VENTRICLE RECONSTRUCTION TRIAL PUBLIC DATASET
Authors: Lisa Maria DiPietro, Ravi Thiagarajan, Jane Newburger, Lynn Sleeper
Journal: Journal of the American College of Cardiology (2019)
Abstract 535: Differences in Energetic Remodeling Between Right and Left Atria in Patients With Atrial Fibrillation
Authors: Larisa Emelyanova, Steve Komas, Susan Olet, Sean Ryan, Catherine Warner, Farhan Rizvi, Gracious R. Ross, David C. Kress, Daniel P. O’Hair, Francis Downey, Arshad Jahangir
Journal: Circulation Research (2018)

Introduction: Right and left atria have different susceptibilities toward developing atrial fibrillation (AF). The molecular bases of these differences are not well characterized. Given the complexity of AF development and progression, understanding AF-associated changes in myocardial energetics between the atria will help improve mechanistic insights and therapeutics for better clinical management of AF. The aim was to compare changes in mitochondrial oxidative phosphorylation system (OXPHOS), glycolysis and Krebs cycle metabolites in right atrial (RAA) and left atrial (LAA) appendage tissue from patients with (AF) and without (non-AF) AF. Methods: RAA and LAA from well-matched AF (n=54) and non-AF (n=58) patients undergoing elective open heart surgery was collected. Functional activity of OXPHOS complexes I-V was measured spectrophotometrically. Protein expression level of OXPHOS complexes was determined by Western blot. OXPHOS gene expression level was performed using RT-PCR. Metabolites were profiled using high performance liquid chromatography coupled to tandem mass spectrometry. Comparison between groups was done applying the 2 sample t - and Wilcoxon rank sum tests with 5% level of significance. Results: The most significant AF-associated alterations in myocardial energetics were observed in RAA. In AF patients, out of 84 OXPHOS genes, expression of 14 genes was significantly reduced in RAA (p&lt;0.05) and 2 genes was reduced in LAA (p&lt;0.05). There was AF-associated reduction in complex I (p=0.01) and IV (p=0.04) protein expression in RAA without changes in LAA. Unlike LAA, mitochondria from RAA revealed decline in complex I (p=0.01) and II (p=0.03) activity in AF compared to non-AF patients. In AF patients, glycolysis metabolites level of glucose-6-phosphate and phosphoenolpyruvate was reduced in RAA (p=0.03), whereas 2-phosphoglycerate was reduced in LAA (p=0.02). AF was related with decrease in NAD + (p=0.03), GDP (p=0.05), citrate (p=0.03), total pool of adenine nucleotides (p=0.02) and glutathione (p=0.03) level in RAA without changes in LAA. Conclusion: AF is associated with different energetic remodeling in right and left atria, suggesting that dissimilar mechanisms may contribute to development and progression of AF.
Tumour necrosis factor superfamily members in ischaemic vascular diseases
Authors: Megan Nash, Jordan P McGrath, Siân P Cartland, Sanjay Patel, Mary M Kavurma
Journal: Cardiovascular Research (2019)

Current treatment of ischaemic vascular diseases such as coronary and peripheral artery disease includes angioplasty and bypass grafting, as well as lipid lowering therapies and control of other cardiovascular risk factors. Numerous members of the tumour necrosis factor superfamily (TNFSF) have recently shown emerging roles in both the protection and progression of such diseases. Understanding the role TNFSF members play in ischaemic vascular disease may provide insight into the development of novel therapeutics to prevent or treat diseases relating to atherosclerosis and ischaemia. This review summarizes the most recent findings relating to TNFSF members and the mechanisms that precede ischaemic vascular disease progression, particularly endothelial dysfunction, chronic inflammation, and atherosclerotic plaque development. This review also explores recent translational research on the role of TNFSF therapies in cardiovascular disease.
<b>Low-Dose Amitriptyline for Chronic Low Back Pain—Reply</b>
Authors: Donna M. Urquhart, Anita Wluka, Flavia Cicuttini
Journal: JAMA Internal Medicine (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Abstract 270: Long term Caloric Restriction and Myocardial Aging in Non Human Primates
Authors: Niranjana Natarajan, Spencer H Kiehm, Jishnu Das, Annie C Wang, Julie A Mattison, Ricki J Colman, Richard T Lee
Journal: Circulation Research (2018)

Caloric restriction (CR) has been shown to decrease aging and increase the lifespan of several model organisms. However, in two on-going independent, long-term CR studies in non-human primates (NHP) at the National Institute of Aging (NIA) and University of Wisconsin, Madison (UW) the outcome has been more complex. While CR monkeys in the UW study have experienced a significant increase in lifespan relative to their study controls, this was not the case for the NIA study. There, CR did not increase lifespan compared to the already long-lived controls. Yet, in both studies CR was associated with a decrease in the occurrence of age-related diseases. Left ventricle (LV) samples were provided from the rhesus monkeys from both studies to investigate the effect of long-term CR on myocardial pathology and aging in these two cohorts of non-human primates (NHPs). Although CR did not reduce cardiac fibrosis or hypertrophy in either study, there was a 5.9-fold increase in fibrosis (p&lt;0.0001) in LV tissue from the UW study compared to NIA, irrespective of CR treatment. Myocardial mTOR levels were reduced with CR in the UW study, only. These findings indicate that the severity of cardiac fibrosis may not be susceptible to the mechanisms by which CR is affecting disease progression, and myocardial mTOR is apparently differently affected dependent on the study paradigm. Interestingly, the diet administered by the UW study contained a much higher sucrose content (28.5% sucrose by weight), compared to that of the NIA diet (3.9% sucrose by weight). This raises the intriguing possibility that myocardial fibrosis in NHPs may be driven by a high sucrose diet. Abbreviations: CR: Caloric Restriction NHP: Non-human primate mTOR: mechanistic Target of Rapamycin NIA: National Institute on Aging UW: University of Wisconsin, Madison
Abstract 461: Prospective Isolation of Heart Field Specific Cardiomyocytes from Differentiating Human Embryonic Stem Cells
Authors: James L Engel, Arash Pezhouman, Ngoc B Nguyen, Peng Zhao, Suhail Khoja, Rhys J Skelton, Debashis Sahoo, David A Elliott, Reza Ardehali
Journal: Circulation Research (2018)

Cardiovascular disease (CVD) is the leading cause of death worldwide. Human embryonic stem cell (hESC) derived cardiovascular progenitor cells (CPCs) or cardiomyocytes (CMs) represent a promising candidate for cell-based therapies to treat CVD. Following a myocardial infarction there is extensive CM death and damage primarily localized to the left ventricle of the heart, which is predominantly derived from first heart field (FHF) CPCs during development. This is important in future developmental and regenerative therapy studies since heart field specific cardiac cells will be desired. Current hESC differentiation protocols as well as the use of cardiac-specific reporter lines, yield a mixture of cardiac cells without the ability to isolate heart field specific cardiac progenitors and their associated progeny. Here we generated and characterized a FHF specific TBX5- TdTomato/W hESC reporter line to show that TBX5 + cells represent an enriched population of FHF CPCs that can give rise to CMs, endothelial and smooth muscle cells in vitro . Transplantation of hESC-derived TBX5 + and TBX5 - CPCs into the injured left ventricle of mice showed that these cells were able to survive and predominantly gave rise to CMs without functional integration into the host myocardium. Furthermore, RNA-sequencing analysis of hESC-derived cardiac cells at different stages of development suggested that while TBX5 expression leads to an enrichment of FHF- derived CMs, TBX5 - cells also generate cardiac cells that resemble second heart field (SHF) CMs at the transcriptional level. To enable prospective isolation of FHF and SHF CMs we generated a double transgenic hESC reporter line TBX5 TdTomato/W /NKX2-5 eGFP/W . Using immunostaining, qPCR and electrophysiological studies we were able to confirm the isolation of FHF and SHF specific CMs from differentiating hESCs. Finally, we show that using the novel surface marker, CORIN, we can isolate FHF CMs without the use of genetic reporters. Our studies provide valuable information and resources on the production of heart field specific CMs from hESCs for cell-based therapies to treat CVD.
Immune Mediated Mechanisms of Resistance to Daratumumab
Authors: Domenico Viola, Ada Dona, Emine Gulsen Gunes, Estelle Troadec, Xiwei Wu, Sergio Branciamore, Tinisha McDonald, Lucy Ghoda, Ashish Streatfield, James F Sanchez, Chatchada Karanes, Myo Htut, Michael Rosenzweig, Jonathan J Keats, Steven T Rosen, Guido Marcucci, Amrita Krishnan, Flavia Pichiorri
Journal: Blood (2018)
AG10 CONSISTENTLY STABILIZES TRANSTHYRETIN TO A HIGH LEVEL IN BOTH WILD TYPE AND MUTANT AMYLOID CARDIOMYOPATHY: RESPONDER ANALYSES FROM A PHASE 2 CLINICAL TRIAL
Authors: Jonathan C. Fox, Stephen Heitner, Rodney Falk, Martha Grogan, Daniel Jacoby, Daniel Judge, Mathew Maurer, Van Selby, Sanjiv Shah, Ronald Witteles, Satish Rao, Uma Sinha
Journal: Journal of the American College of Cardiology (2019)
In Situ Generated Medical Devices
Authors: Daniel Cohn, Aaron Sloutski, Ariel Elyashiv, Vijaykumar B. Varma, Raju Ramanujan
Journal: Advanced Healthcare Materials (2019)

Abstract Medical devices play a major role in all areas of modern medicine, largely contributing to the success of clinical procedures and to the health of patients worldwide. They span from simple commodity products such as gauzes and catheters, to highly advanced implants, e.g., heart valves and vascular grafts. In situ generated devices are an important family of devices that are formed at their site of clinical function that have distinct advantages. Among them, since they are formed within the body, they only require minimally invasive procedures, avoiding the pain and risks associated with open surgery. These devices also display enhanced conformability to local tissues and can reach sites that otherwise are inaccessible. This review aims at shedding light on the unique features of in situ generated devices and to underscore leading trends in the field, as they are reflected by key developments recently in the field over the last several years. Since the uniqueness of these devices stems from their in situ generation, the way they are formed is crucial. It is because of this fact that in this review, the medical devices are classified depending on whether their in situ generation entails chemical or physical phenomena.
HMGA2 mRNA Expression in Patients with Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN)
Authors: Keiji Minakawa, Koki Ueda, Akiko Shichishima, Hiroshi Ohkawara, Kazuei Ogawa, Takayuki Ikezoe, Yayoi Shikama, Kenneth E Nollet, Kazuhiko Ikeda
Journal: Blood (2018)
Abstract 10276: Combined Stress Cardiac Magnetic Resonance and Liver Imaging for Liver Transplant Candidates; a Proof of Concept Approach
Authors: Asghar Fakhri, Ngoc Thai, Jose Oliva, Michael Dishart, Bryan Veynovich, June Yamrozik, Ronald Williams, Saundra Grant, Jacqueline Poydence, Kusum Tom, Anil Singh, Swami Nathan, Robert W Biederman
Journal: Circulation (2011)

Background Preoperative imaging of liver transplant (LvTx) candidates can be cumbersome, time-consuming and expensive, due to need to perform separate echocardiogram, stress test, and liver/vascula...
PROGNOSIS AND PREDICTORS OF RECURRENCE IN PATIENTS OF REVERSIBLE SYMPTOMATIC BRADYARRYTHMIA: RESULTS FROM AN OBSERVATIONAL STUDY
Authors: Akhil Kumar Sharma, Sudhanshu Dwivedi, Anant Agrawal, Kapildev Doomra, Gaurav Kumar Chaudhary, Sharad Chandra, Rishi Sethi, Akshyaya Pradhan, Pravesh Vishwakarma, Monika Bhandari, Varun Narain
Journal: Journal of the American College of Cardiology (2019)
Use of postmenopausal hormone therapy and risk of Alzheimer’s disease in Finland: nationwide case-control study
Authors: Hanna Savolainen-Peltonen, Päivi Rahkola-Soisalo, Fabian Hoti, Pia Vattulainen, Mika Gissler, Olavi Ylikorkala, Tomi S Mikkola
Journal: BMJ (2019)

To compare the use of hormone therapy between Finnish postmenopausal women with and without a diagnosis for Alzheimer's disease.Nationwide case-control study.Finnish national population and drug register, between 1999 and 2013.All postmenopausal women (n=84 739) in Finland who, between 1999 and 2013, received a diagnosis of Alzheimer's disease from a neurologist or geriatrician, and who were identified from a national drug register. Control women without a diagnosis (n=84 739), matched by age and hospital district, were traced from the Finnish national population register.Data on hormone therapy use were obtained from the Finnish national drug reimbursement register.Odds ratios and 95% confidence intervals for Alzheimer's disease, calculated with conditional logistic regression analysis.In 83 688 (98.8%) women, a diagnosis for Alzheimer's disease was made at the age of 60 years or older, and 47 239 (55.7%) women had been over 80 years of age at diagnosis. Use of systemic hormone therapy was associated with a 9-17% increased risk of Alzheimer's disease. The risk of the disease did not differ significantly between users of estradiol only (odds ratio 1.09, 95% confidence interval 1.05 to 1.14) and those of oestrogen-progestogen (1.17, 1.13 to 1.21). The risk increases in users of oestrogen-progestogen therapy were not related to different progestogens (norethisterone acetate, medroxyprogesterone acetate, or other progestogens); but in women younger than 60 at hormone therapy initiation, these risk increases were associated with hormone therapy exposure over 10 years. Furthermore, the age at initiation of systemic hormone therapy was not a decisive determinant for the increase in risk of Alzheimer's disease. The exclusive use of vaginal estradiol did not affect the risk of the disease (0.99, 0.96 to 1.01).Long term use of systemic hormone therapy might be accompanied with an overall increased risk of Alzheimer's disease, which is not related to the type of progestogen or the age at initiation of systemic hormone therapy. By contrast, use of vaginal estradiol shows no such risk. Even though the absolute risk increase for Alzheimer's disease is small, our data should be implemented into information for present and future users of hormone therapy.
HOW MUCH ATRIAL FIBRILLATION IS TOO MUCH? TREATMENT BENEFIT OF ANTICOAGULATION BASED ON THRESHOLD OF DEVICE-DETECTED AF
Authors: Alexander Perino, Jun Fan, Mariam Askari, Paul Heidenreich, Edmund Keung, Jonathan Piccini, Paul Ziegler, Mintu Turakhia
Journal: Journal of the American College of Cardiology (2019)
Abstract 340: Cardiomyocyte-Derived Mechanical Signals Function in a Paracrine Manner to Regulate Tissue Stiffness and Myocardial Proliferation
Authors: Caimei Zhang, Sabrina Emms, Glenn Radice
Journal: Circulation Research (2018)

Cells sense and transduce mechanical signals through cell-cell adhesions and cell-extracellular matrix adhesions. After birth, contractile force generation and tissue stiffness increase as cardiac output increases to support the needs of the newborn organism. During this postnatal period, the N-cadherin adhesion complex assembles at the intercalated disc (ID) as integrin-fibronectin (FN) adhesions decrease, accompanying the switch from hyperplastic to hypertrophic growth. However, little is known regarding the reciprocity between integrin and N-cadherin adhesions in the regulation of cell cycle withdrawal that occurs in cardiomyocytes after birth. α-catenins function as mechanosensors and transduce the intercellular force from N-cadherin to the actin cytoskeleton. Cardiac-specific αE- and αT-catenins double knockout (DKO) mice exhibit sustained cardiomyocyte proliferation beyond the first week of life. To investigate the role of cell-matrix interactions in DKO hearts, the spatial distribution of integrin-FN complexes was examined at postnatal day (P) 4, P7, P14, and P60. DKO hearts exhibited aberrant N-cadherin localization accompanied by altered distribution of α5/β1 integrin, the primary FN receptor. Normally found at the lateral membrane, α5 and β1 accumulated at the ID while N-cadherin was reduced at the termini. FN matrix assembly, as monitored by immunofluorescent staining and its insolubility in the detergent deoxycholate, was increased in DKO hearts. Meanwhile, focal adhesion kinase (FAK) was activated in early postnatal DKO hearts. Complementary experiments performed with deformable substrata demonstrated that stiffness-mediated proliferation was dependent on FAK activity. Finally, treatment of DKO pups with the lysyl oxidase inhibitor, β-aminopropionitrile (BAPN), was sufficient to reduce cardiomyocyte proliferation to wild-type levels suggesting that matrix assembly and tissue stiffness feedback to promote cardiomyocyte proliferation in DKO hearts. This data demonstrates that α-catenins regulate the balance between cell-cell and cell-matrix adhesions, which, in turn, controls cardiomyocyte proliferation, thus providing a molecular explanation for loss of regenerative potential shortly after birth.
THE NOVEL GC-A/CGMP ACTIVATING DESIGNER M-ATRIAL NATRIURETIC PEPTIDE POTENTLY REDUCES BLOOD PRESSURE IN A GENETIC MODEL OF HYPERTENSION AND POTENTIATES THE ACTIONS OF FUROSEMIDE
Authors: Nina Dzhoyashvili, Seethalakshmi Iyer, Yang Chen, Gerald Harders, Jeson Sangaralingham, Horng Chen, John Burnett
Journal: Journal of the American College of Cardiology (2019)
PULMONARY DIASTOLIC DECAY TIME IS A NOVEL INDEX ASSOCIATED WITH SEVERE HEMODYNAMIC IMPAIRMENTS IN PATIENTS WITH PULMONARY HYPERTENSION
Authors: Sula Mazimba, Priscilla Baafi, Sthuthi David, Manu Mysore, Douglas Sawch, Corey Benjamin, Nishaki Mehta, Javed Butler, Jose Tallaj, Jamie Kennedy, Andrew Mihalek, John Hossack, Khadijah Breathett, Kimberly Chadwell, Kenneth Bilchick
Journal: Journal of the American College of Cardiology (2019)
Abstract 20250: Evidence of Abnormal Hemoglobin Processing and Generation of Cell Free Hemoglobin Across the Pulmonary Vasculature in Human Pulmonary Arterial Hypertension
Authors: Rezzan Hekmat, Niki P Fortune, Eric D Austin, David R Janz, Christopher Jetter, Anna R Hemnes, Evan L Brittain
Journal: Circulation (2017)

Introduction: We recently observed elevated cell free hemoglobin (CFH), a pulmonary vasoconstrictor, in humans with pulmonary arterial hypertension (PAH). The mechanism of CFH elevation in PAH is u...
PROGNOSTIC IMPLICATIONS OF BASELINE PULMONARY VASCULAR RESISTANCE DETERMINED BY TRANSTHORACIC ECHOCARDIOGRAPHY PRIOR TO TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Zach Rozenbaum, Yan Topilsky, Simon Biner, Arie Steinvil, Yaron Arbel, Shmuel Banai, Ariel Finkelstein, Amir Halkin
Journal: Journal of the American College of Cardiology (2019)