tbuckley/cabot-search huggingface dataset:
Dimethyloxallyl glycine/nanosilicates-loaded osteogenic/angiogenic difunctional fibrous structure for functional periodontal tissue regeneration
Authors: Lingling Shang, Ziqi Liu, Baojin Ma, Jinlong Shao, Bing Wang, Chenxi Ma, Shaohua Ge
Journal: Bioactive Materials (2020)

The coupled process of osteogenesis-angiogenesis plays a crucial role in periodontal tissue regeneration. Although various cytokines or chemokines have been widely applied in periodontal in situ tissue engineering, most of them are macromolecular proteins with the drawbacks of short effective half-life, poor stability and high cost, which constrain their clinical translation. Our study aimed to develop a difunctional structure for periodontal tissue regeneration by incorporating an angiogenic small molecule, dimethyloxalylglycine (DMOG), and an osteoinductive inorganic nanomaterial, nanosilicate (nSi) into poly (lactic-co-glycolic acid) (PLGA) fibers by electrospinning. The physiochemical properties of DMOG/nSi-PLGA fibrous membranes were characterized. Thereafter, the effect of DMOG/nSi-PLGA membranes on periodontal tissue regeneration was evaluated by detecting osteogenic and angiogenic differentiation potential of periodontal ligament stem cells (PDLSCs) in vitro. Additionally, the fibrous membranes were transplanted into rat periodontal defects, and tissue regeneration was assessed with histological evaluation, micro-computed tomography (micro-CT), and immunohistochemical analysis. DMOG/nSi-PLGA membranes possessed preferable mechanical property and biocompatibility. PDLSCs seeded on the DMOG/nSi-PLGA membranes showed up-regulated expression of osteogenic and angiogenic markers, higher alkaline phosphatase (ALP) activity, and more tube formation in comparison with single application. Further, in vivo study showed that the DMOG/nSi-PLGA membranes promoted recruitment of CD90+/CD34- stromal cells, induced angiogenesis and osteogenesis, and regenerated cementum-ligament-bone complex in periodontal defects. Consequently, the combination of DMOG and nSi exerted admirable effects on periodontal tissue regeneration. DMOG/nSi-PLGA fibrous membranes could enhance and orchestrate osteogenesis-angiogenesis, and may have the potential to be translated as an effective scaffold in periodontal tissue engineering.
SAT0159 Non-vertebral fractures and its associates in female rheumatoid arthritis (ra) patients: the oslo, truro, and amsterdam (ostra) collaborative study
Authors: G Haugeberg, M Lodder, W Lems, R Ørstavik, B Dijkmans, T Kvien, A Woolf
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> <h3>Objectives</h3> To examine non-vertebral fractures (N-VF) in RA patients, of similar age, disease duration and rheumatoid factor status recruited from three European countries, and their association with bone mineral density (BMD), demographic and disease related associates. <h3>Methods</h3> 150 (50 from each country) consecutive female RA patients (ACR 1987 criteria, disease duration &gt; 5 yrs, age 50–70 yrs) visiting the out-patient Department of Rheumatology in the participating centres were included. Data on N-VF occurring after age 25 and after RA diagnosis, demographics and measures of disease activity were collected. Dual energy X-ray absorptiometry (DXA) was used to measure femoral neck and spine L2–4 BMD adjusted for age, weight and height. BMD was expressed in g/cm<sup>2</sup>. To investigate associations between history of N-VF and disease related variables, we used bi-variate (Students t-test, Pearson Chi square test) and multivariate statistical analyses (logistic regression). <h3>Results</h3> A total of 25 patients (Oslo 11, Truro 1 and Amsterdam 13 patients) reported a history of previous N-VF (total number of fractures 34). In the Truro patients BMD (adjusted for age, weight and height) in both spine and hip was higher than in Oslo and Amsterdam patients. A statistical difference between those with and without a previous N-VF was found for the variables (mean (SD)) listed in the Table 1 and for disease duration (22.6 vs. 16.6 yrs, p = 0.01). BMD in the femoral neck but not in the spine was independently associated with a history of a N-VF after adjusting for age, weight, height, disease duration and Larsen score using logistic regression. <h3>Conclusion</h3> Our cross sectional findings indicate that BMD is a risk factor for N-VF in female RA patients. Weather this concerns a causal relationship needs confirmation in prospective studies.
The Easix (Endothelial Activation and Stress Index) Score Predicts for CAR T Related Toxicity in Patients Receiving Axicabtagene Ciloleucel (axi-cel) for Non-Hodgkin Lymphoma (NHL)
Authors: Uri Greenbaum, Paolo Strati, Rima M. Saliba, Janet Torres, Gabriela Rondon, Yago Nieto, Chitra Hosing, Samer A. Srour, Jason Westin, Luis Fayad, Hun Ju Lee, Swaminathan P Iyer, Loretta J. Nastoupil, Simrit Parmar, Maria Alma Rodriguez, Felipe Samaniego, Raphael Eric Steiner, Michael Wang, Chelsea C. Pinnix, Christopher Flowers, Sudhakar Tummala, Jeremy Ramdial, Fevzi F. Yalniz, Misha Hawkins, Katayoun Rezvani, Richard E. Champlin, Elizabeth J. Shpall, Sattva S. Neelapu, Partow Kebriaei, Sairah Ahmed
Journal: Blood (2020)
Molecular Characterization of Two Homozygous Factor VII Variants Associated with Intracranial Bleeding
Authors: Elisabeth Andersen, Maria Eugenia Chollet, Marit Sletten, Benedicte Stavik, Christiane Filion Myklebust, Ellen Skarpen, Paul Hoff Backe, Per Morten Sandset, Heidi Glosli, Carola Henriksson, Nina Iversen
Journal: Blood (2020)
Bridging the Gap in Access to Transplant for Underserved Minority Patients Using Mismatched Unrelated Donors and Post-Transplant Cyclophosphamide: A National Marrow Donor Program/be the Match (NMDP/BTM) Initiative
Authors: Bronwen E. Shaw, Antonio Jimenez-Jimenez, Linda J. Burns, Brent Logan, Farhad Khimani, Brian C. Shaffer, Nirav N. Shah, Alisha Mussetter, Xiao-Ying Tang, John M McCarty, Asif Alavi, Nosha Farhadfar, Katarzyna Jamieson, Nancy M. Hardy, Hannah Choe, Richard F. Ambinder, Claudio Anasetti, Miguel-Angel Perales, Alan Howard, Krishna V Komanduri, Leo Luznik, Maxim Norkin, Joseph Pidala, Voravit Ratanatharathorn, Dennis L. Confer, Steven M Devine, Mary M. Horowitz, Javier Bolanos-Meade
Journal: Blood (2020)
Treatment of Immune Thrombocytopenia (ITP) with Eltrombopag - Results of the 3rd Interim Analysis of the German Non-Interventional Trial RISA
Authors: Oliver Meyer, Martina Stauch, Dietrich Kaempfe, Rudolf Schlag, Marcel Reiser, Eyck von der Heyde, Andreas Josting, Margarete Plath, Nadine Ballerstädt, Petra Stark-Lorenzen, Axel Matzdorff
Journal: Blood (2020)
Debulking Regimens Prior to Initiating Venetoclax Therapy in Untreated Patients with Chronic Lymphocytic Leukemia: Interim Results from a Phase 3b Study
Authors: Ian W. Flinn, David Andorsky, Jason M. Melear, Sudhir Manda, Bertrand M. Anz, Kathryn Kolibaba, Habte A. Yimer, John M. Burke, Suzanne R. Fanning, Jay Courtright, Miguel Islas-Ohlmayer, Suman Kambhampati, Daniel Dingfeng Jiang, John C. Pesko, Tamas Vizkelety, Simon Sharmokh, Jeff P Sharman
Journal: Blood (2020)
Targeting Protein S Using Small Interfering RNA Is Well Tolerated and Protects Mice with Hemophilia a from Acute Hemarthrosis
Authors: Raja Eladnani Prince, Ute Schaeper, Sibylle Dames, Sara Calzavarini, Claudia Quarroz, Maria Desiré Reina Caro, Astrid Chanfon Bätzner, Kathrin Löffner, Mona Eisermann, Anne Angelillo-Scherrer
Journal: Blood (2020)
Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells
Authors: Alexander Carpinteiro, Michael J. Edwards, Markus Hoffmann, Georg Kochs, Barbara Gripp, Sebastian Weigang, Constantin Adams, Elisa Carpinteiro, Anne Gulbins, Simone Keitsch, Carolin Sehl, Matthias Soddemann, Barbara Wilker, Markus Kamler, Thomas Bertsch, Karl S. Lang, Sameer Patel, Gregory C. Wilson, Silke Walter, Hartmut Hengel, Stefan Pöhlmann, Philipp A. Lang, Johannes Kornhuber, Katrin Anne Becker, Syed A. Ahmad, Klaus Fassbender, Erich Gulbins
Journal: Cell Reports Medicine (2020)

The acid sphingomyelinase/ceramide system plays an important role in bacterial and viral infections. Here, we report that either pharmacological inhibition of acid sphingomyelinase with amitriptyline, imipramine, fluoxetine, sertraline, escitalopram, or maprotiline or genetic downregulation of the enzyme prevents infection of cultured cells or freshy isolated human nasal epithelial cells with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or vesicular stomatitis virus (VSV) pseudoviral particles (pp-VSV) presenting SARS-CoV-2 spike protein (pp-VSV-SARS-CoV-2 spike), a bona fide system mimicking SARS-CoV-2 infection. Infection activates acid sphingomyelinase and triggers a release of ceramide on the cell surface. Neutralization or consumption of surface ceramide reduces infection with pp-VSV-SARS-CoV-2 spike. Treating volunteers with a low dose of amitriptyline prevents infection of freshly isolated nasal epithelial cells with pp-VSV-SARS-CoV-2 spike. The data justify clinical studies investigating whether amitriptyline, a safe drug used clinically for almost 60 years, or other antidepressants that functionally block acid sphingomyelinase prevent SARS-CoV-2 infection.
Viral Reactivation in Acute Leukemia Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation in Complete Remission: Stimulation of the Immune System
Authors: Sandrine Loron, Mohamad Sobh, Bruno Lina, Florence Ader, Myriam Renault, Marie-Cecile Michallet, Hélène Labussière, Mauricette Michallet
Journal: Blood (2020)
Clinical Validation of a NGS Capture Panel to Identify Mutations, Copy Number Variations and Translocations in Patients with Multiple Myeloma
Authors: Isabel Cuenca, Alejandro Medina, Laura Rosinol, Iria Vazquez, Ricardo Sanchez, Norma C. Gutierrez, Yanira Ruiz-Heredia, Santiago Barrio, Albert Oriol, Maria Luisa Martin-Ramos, Manuela Fernández-Guijarro, María Jesús Blanchard, Rafael Rios, Anna Sureda Balari, Miguel T Hernández, Javier de la Rubia, Gorka Alkorta, Xabier Agirre, Gonzalo R Ordóñez, Rafael Valdés-Mas, Maria-Victoria Mateos, Joan Blade Creixenti, Juan Jose Lahuerta, Jesus F. San-Miguel, Maria Jose Calasanz, Ramon Garcia-Sanz, Joaquin Martinez-Lopez
Journal: Blood (2020)
Implementation science and the Health Resources and Services Administration’s Ryan White HIV/AIDS Program’s work towards ending the HIV epidemic in the United States
Authors: Demetrios Psihopaidas, Stacy M. Cohen, Tanchica West, Latham Avery, Antigone Dempsey, Kim Brown, Corliss Heath, Adan Cajina, Harold Phillips, Steve Young, April Stubbs-Smith, Laura W. Cheever
Journal: PLoS Medicine (2020)

Demetrios Psihopaidas and co-authors discuss the implementation science framework of an HIV/AIDS program in the United States.
Analysis of Free-Text Responses in an International Myeloproliferative Neoplasms Patient Survey to Assess Impact of the COVID-19 Pandemic on Clinical Care
Authors: Blake T. Langlais, Carolyn Mead-Harvey, Heidi E. Kosiorek, Gina L. Mazza, Ruben Mesa, Jeanne M. Palmer, Amylou C. Dueck
Journal: Blood (2020)
A Prognostic Model Incorporating Tumor Lesion Morphology and Texture Features Identifies High-Risk Patient Subpopulations in <i>De Novo</i> DLBCL and FL
Authors: Xiao Li, Skander Jemaa, Richard AD Carano, Thomas Bengtsson, Joseph N Paulson, Gunther Jansen, Tina G Nielsen, Derrek P Hibar
Journal: Blood (2020)
Long-Term Follow-up of the Combination of Low-Intensity Chemotherapy Plus Inotuzumab Ozogamicin with or without Blinatumomab in Patients with Relapsed-Refractory Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia: A Phase 2 Trial
Authors: Koji Sasaki, Hagop M. Kantarjian, Farhad Ravandi, Nicholas J. Short, Partow Kebriaei, Xuelin Huang, Nitin Jain, Marina Konopleva, Guillermo Garcia-Manero, Richard E. Champlin, Tapan M. Kadia, Koichi Takahashi, Naval Daver, Hind Rafei, Joseph D. Khoury, Jeffrey L. Jorgensen, Sa A Wang, Maria R Khouri, Jovitta Jacob, Rebecca Garris, Susan M. O'Brien, Elias Jabbour
Journal: Blood (2020)
An International Multicentric Observational Study on the Use of Ruxolitinib in Patients with Polycythemia Vera Resistant or Intolerant to Hydroxyurea: Results from Interim Analysis
Authors: Peter AW te Boekhorst, Alexandre Theocharides, Heinz Gisslinger, Timothy Devos, Eric Lippert, Damianos Sotiropoulos, Miklos Egyed, Valerio De Stefano, Vincenzo Accurso, Alessandra Iurlo, Anders E.A. Dahm, Regina Garcia-Delgado, Nathan Cantoni, Mike Zuurman, Michael Zaiac, Erik Houtsma, Amir Iqbal, Paola Di Matteo, Alberto Alvarez-Larrán
Journal: Blood (2020)
A Phase I Study of Anti-ICOS Antibody MEDI-570 for Relapsed/Refractory (R/R) Peripheral T-Cell Lymphoma (PTCL) and Angioimmunoblastic T-Cell Lymphoma (AITL) (NCI-9930)
Authors: Julio C. Chavez, Francine M. Foss, Basem M. William, Jonathan E Brammer, Sonali M. Smith, Anca Prica, Jasmine M. Zain, Joseph M Tuscano, Martha Glenn, Neha Mehta-Shah, Ben X Wang, Stephanie Zantinge, Lisa Wang, Ling Zhang, Anmarie Boutrin, Weiguang Zhao, Lily Cheng, Nathan Standifer, Gianluca Carlesso, Jeffrey Moscow, Lillian Siu
Journal: Blood (2020)
Molecular and Expression Characterization of Monosomy 7 and Del(7q)
Authors: Vera Adema, Cassandra M Kerr, Hassan Awada, Sunisa Kongkiatkamon, Bhumika J. Patel, Mikkael A. Sekeres, Valeria Visconte, John Barnard, Jaroslaw P. Maciejewski, Torsten Haferlach
Journal: Blood (2020)
Abstract 251: Modeling LMNA Associated Cardiomyopathy Using Patient-Specific Human Induced Pluripotent Stem Cells
Authors: Hananeh Fonoudi, Jane Wilcox, Paul W Burridge
Journal: Circulation Research (2020)

Mutations in LMNA are the most prevalent cause of dilated cardiomyopathy (DCM), accounting for up to 5-10% all the familial DCM. LMNA encodes the lamin A/C proteins which form filamentous structures that underline nuclear envelop. Sudden cardiac death and arrhythmia are common in patients with LMNA mutations. Despite recent advancement in the field, still the exact mechanism that link the mutation in LMNA to the formation of DCM and arrythmia is still largely unknown. In this study, we have generated an in vitro model of LMNA associated DCM using patient specific human induced pluripotent stem cells (hiPSCs). A family with pathogenic deletion in LMNA gene (c. 1142-1157 + 1del17) and history of DCM were selected. hiPSCs were generated from 4 affected individuals in the family and 5 healthy individuals. hiPSCs were then directly differentiated into cardiomyocytes and assessed at day 30 post differentiation. Cardiomyocytes derived from LMNA variant patients showed significantly higher level of nuclear deformation compared to control group. Moreover, after 2 days of mechanical stress cardiomyocytes derived from LMNA variant patients showed significantly higher level of nuclear dysmorphism while the control group were not affected. Field potential analysis of cardiomyocytes derived from LMNA patients compared to controls using multielectrode array revealed significantly higher beat rate irregularity in LMNA variant group which was consistent with the clinical symptoms of the patients. Furthermore, calcium transient of the cardiomyocytes derived from LMNA variant patients were significantly different from control group. Finally, patch clamp analysis also proved our previous findings and showed electrophysiological abnormalities in patients’ cells. In summary our finding thus far shows significant electrophysiological differences between cardiomyocytes derived from LMNA variant patients and control group which could help to unravel the cellular mechanism underlying formation of arrhythmia in LMNA variant patients.
Patient-Specific Metabolism Assessed By Visceral Fat and Diabetes May Alter Prognosis in Relapsed/Refractory Hodgkin Lymphoma
Authors: Priyanka Pullarkat, Rehan Nizamuddin, Shama Jaswal, Marcus Watkins, Nancy L. Bartlett, Amanda F Cashen, Joseph Ippolito, Neha Mehta-Shah
Journal: Blood (2020)
Memory in low-grade glioma patients treated with radiotherapy or temozolomide: a correlative analysis of EORTC study 22033-26033
Authors: Martin Klein, A Josephine Drijver, Martin J van den Bent, Jacolien C Bromberg, Khê Hoang-Xuan, Martin J B Taphoorn, Jaap C Reijneveld, Mohamed Ben Hassel, Elodie Vauleon, Daniëlle B P Eekers, Tzahala Tzuk-Shina, Anna Lucas, Salvador Villà Freixa, Vasilis Golfinopoulos, Thierry Gorlia, Andreas F Hottinger, Roger Stupp, Brigitta G Baumert
Journal: Neuro-Oncology (2020)

Abstract Background EORTC study 22033–26033 showed no difference in progression-free survival between high-risk low-grade glioma receiving either radiotherapy (RT) or temozolomide (TMZ) chemotherapy alone as primary treatment. Considering the potential long-term deleterious impact of RT on memory functioning, this study aims to determine whether TMZ is associated with less impaired memory functioning. Methods Using the Visual Verbal Learning Test (VVLT), memory functioning was evaluated at baseline and subsequently every 6 months. Minimal compliance for statistical analyses was set at 60%. Conventional indices of memory performance (VVLT Immediate Recall, Total Recall, Learning Capacity, and Delayed Recall) were used as outcome measures. Using a mixed linear model, memory functioning was compared between treatment arms and over time. Results Neuropsychological assessment was performed in 98 patients (53 RT, 46 TMZ). At 12 months, compliance had dropped to 66%, restricting analyses to baseline, 6 months, and 12 months. At baseline, patients in either treatment arm did not differ in memory functioning, sex, age, or educational level. Over time, patients in both arms showed improvement in Immediate Recall (P = 0.017) and total number of words recalled (Total Recall; P &amp;lt; 0.001, albeit with delayed improvement in RT patients (group by time; P = 0.011). Memory functioning was not associated with RT gross, clinical, or planned target volumes. Conclusion In patients with high-risk low-grade glioma there is no indication that in the first year after treatment, RT has a deleterious effect on memory function compared with TMZ chemotherapy.
AB0305 STUDY OF CORRELATION OF B-CELL LEVEL AND PROGRESSION OF BONE DESTRUCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS RECEIVING RITUXIMAB THERAPY
Authors: A. Kudryavtseva, G. Lukina, A. Smirnov, S. Glukhova, E. Aronova, G. Gridneva
Journal: Annals of the Rheumatic Diseases (2020)

Background: Rheumatoid arthritis is a chronic autoimmune disease characterised by inflammation of the synovial tissue and destruction of the underlying cartilage and bone. The goal of antirheumatic treatment is not only to attenuate the clinical symptoms of joint inflammation, but also to inhibit the progression of joint destruction. Rituximab - it is a chimeric monoclonal antibody that targets the CD20 molecule expressed on the surface of B cells. It has been successfully used to treat rheumatoid arthritis, and it is worth noting that his antidestructive effect sometimes does not meet the clinical. Objectives: The aim of our study was to evaluate the correlation between the degree of В-cell depletion and the development of the clinical and antidestructive effects of Rituximab (RTM) therapy in patients with rheumatoid arthritis (RA). Methods: the study included 108 patients (pts) with rheumatoid arthritis, most are middle-aged women with high disease activity (mean DAS28 6,1±1.04, RF-positive 77%, ACCP-positive 83%) treated with RTX (1000 mgx2 or 500 mgx2). Clinical effect was scored by EULAR criteria, radiographic progression was assessed using Sharp/van der Heijde (SvH) modified scoring method. B-cell level was measured with flow cytometry. Results: patients who were treated by different doses of RTX (500 x2 or 1000 x2) had good response. After 48 week of treatment RTX clinical improvement was achieved in 65% pts, good and moderate response by EULAR criteria in 23 % and 42 % pts respectively. Noteworthy, after 12 months of treatment RTX radiological progression was absent in 50 % pts with high disease activity. There was no significant difference in the degree of B-cell reduction when assessing the antidestructive effect. However, in assessing the clinical effect, it was noted that depletion of B cells in patients with RA in a state of remission (median 0.05% B cells) was more pronounced than in patients with signs of disease activity (2.03% B cells). Conclusion: rituximab therapy slows the radiologic progression regardless of the therapeutic effect. Radiologic progression did not show any dependence on the degree of B-cell reduction. The most pronounced depletion of B cells was observed in RA patients in a state of remission. Disclosure of Interests: Anastasia Kudryavtseva: None declared, Galina Lukina Speakers bureau: Novartis, Pfizer, UCB, Abbvie, Biocad, MSD, Roche, Alexander Smirnov: None declared, Svetlana Glukhova: None declared, Eugenia Aronova: None declared, Galina Gridneva: None declared
Diagnosis of Thoracic Aortic Aneurysms by Computed Tomography Without Allometric Scaling
Authors: Sameh Yousef, Makoto Mori, Syed Usman Bin Mahmood, Roland Assi, Prashanth Vallabhajosyula, Arnar Geirsson, George Tellides
Journal: JAMA Network Open (2020)

This diagnostic study of computed tomography scans at a single tertiary care center compares radiologist descriptions of abnormal size ascending aortas with definitions of aorta diameters defined by nomograms.
Irs1S57X Heterozygous Mutant Mice Display Normal Hematopoiesis and Phenotypic Features, While Homozygous Knockout Exhibit High Fetal or Postnatal Lethality
Authors: Bruna Alves Fenerich, Jaqueline Cristina Fernandes, Cleide Lúcia Araújo Silva, Juan L Coelho-Silva, Antonio Bruno Alves Silva, Natasha Peixoto Fonseca, João Agostinho Machado-Neto, Fabiola Traina
Journal: Blood (2020)
Spatiotemporal Assessment of Immunogenomic Heterogeneity in Multiple Myeloma
Authors: Maximilian Merz, Almuth Maria Anni Merz, Jie Wang, Lei Wei, Ahmed Belal, Ronald Alberico, Qiang Hu, Cherie Rondeau, Kimberly Celotto, AnneMarie W. Block, Hemn Mohammadpour, Megan M. Herr, Theresa E. Hahn, Paul K. Wallace, Joseph Dennis Tario, Jesse Luce, Sean Glenn, Prashant K Singh, Kelvin P. Lee, Song Liu, Philip L. McCarthy, Jens Hillengass
Journal: Blood (2020)
Acute Deep Vein Thrombosis and Association with Popliteal Fossa (Baker's) Cysts in Patients with Lower Extremity Duplex Ultrasound Examination
Authors: Danielle Vlazny, Damon E. Houghton, Ryan Meverden, Paul Daniels, Matthew Bartlett, Gina Hesley, Thanila Macedo, Alexander Lekah, Waldemar E. Wysokinski
Journal: Blood (2020)
Patient global assessment to define remission in rheumatoid arthritis:quo vadis?
Authors: Maarten Boers
Journal: Annals of the Rheumatic Diseases (2020)

The American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) preliminary criteria for remission in rheumatoid arthritis (RA) have found widespread endorsement and adoption since their publication in 2011 (box 1).1 Patients that fulfil the criteria are almost indistinguishable from healthy persons and live a normal life.2 Nevertheless, the criteria are also seen as too strict,3 as not including enough patient-important outcomes4; and their application in patient care, as advised by guideline committees, has problems. Most of the criticism focuses on the inclusion of patient global assessment (PGA) and its threshold. Box 1 ### American College of Rheumatology–European League Against Rheumatism remission criteria.1 #### Boolean-based definition At any time point, patient must satisfy all of the following: Tender joint count ≤l* Swollen joint count ≤l* C reactive protein ≤1 mg/dL Patient global assessment (PGA) ≤1 (on a 0–10 scale)† #### Index-based definition At any time point, patient must have a Simplified Disease Activity Index Score of ≤3.3‡
PATHOGENESIS OF ESSENTIAL HYPERTENSION
Authors: W.H. Birkenhäger, T.L. Kho, P.W. De Leeuw, R. Vandongen, A. Wester, G.A. Zaal, J.J. Brown, A.F. Lever, J.I.S. Robertson, M.A. Schalekamp
Journal: The Lancet (1976)