tbuckley/cabot-search huggingface dataset:
ODYNOPHAGIA - IS IT A SYMPTOM WORTHY OF 2WW GASTROSCOPY?
Authors: R Patel, R Canda, S Haghollahi, K Besherdas
Journal: Endoscopy (2020)

Aims Odynophagia is defined as a painful sensation in the oesophageal region that occurs in relation to swallowing. Endoscopy is the gold standard investigation for the diagnosis of mucosal lesions in the oesophagus. Unlike dysphagia, which has historically been an alarm symptom of oesophageal cancer, odynophagia does not form part of the suspected upper gastrointestinal (GI) cancer referral in the UK. We aimed to compare the standard ‘red flag’ indications for gastroscopy to odynophagia in terms of cancer detection.
SAFE AND EFFICACY OF SINGLE CENTRAL ENDOSCOPIC ULTRASOUND GUIDED NEUROLYSIS OF CELIAC PLEXUS FOR PAIN RELIEF IN UNRESECTABLE PANCREATIC CANCER PATIENTS
Authors: A Rossi, M Piciucchi, D Castellani, H Bertani, A Sbrozzi-Vanni, U Germani, O Morelli, R Conigliaro, R Manta
Journal: Endoscopy (2020)

Aims Unresectable Pancreatic Cancer (UPC) is strongly associated to severe pain difficult to treat with opiate. Endoscopic-Ultrasound-guided celiac plexus neurolysis (EUS-CPN) significant improve pain reducing opiate need in UPC. Recent guidelines suggest combined bilateral EUS-CPN approach, however technical difficulty related to strictly anatomic rapport with vessels it could limit its wide clinical spread. In this view a single central EUS-CPN approach appears easier and faster to implement and learn.
Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19
Authors: Mingfeng Liao, Yang Liu, Jing Yuan, Yanling Wen, Gang Xu, Juanjuan Zhao, Lin Cheng, Jinxiu Li, Xin Wang, Fuxiang Wang, Lei Liu, Ido Amit, Shuye Zhang, Zheng Zhang
Journal: Nature Medicine (2020)

Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.
Establishment of the European meningococcal strain collection genome library (EMSC-GL)
Authors: H B Bratcher, C Brehony, S Heuberger, D Pieridou-Bagatzouni, P Krizova, S Hoffmann, M Toropainen, M K Taha, H Claus, G Tzanakaki, T Erdosi, J Galajeva, A Van der Ende, A Skoczynska, M Pana, A Vaculikova, M Paragi, Maiden Mcj., D Caugant
Journal: Eurosurveillance (2018)
Biofunctional magnesium coated Ti6Al4V scaffold enhances osteogenesis and angiogenesis in vitro and in vivo for orthopedic application
Authors: Peng Gao, Bo Fan, Xiaoming Yu, Wenwen Liu, Jie Wu, Lei Shi, Di Yang, Lili Tan, Peng Wan, Yulin Hao, Shujun Li, Wentao Hou, Ke Yang, Xiaokang Li, Zheng Guo
Journal: Bioactive Materials (2020)

The insufficient osteogenesis and osseointegration of porous titanium based scaffold limit its further application. Early angiogenesis is important for scaffold survival. It is necessary to develop a multifunctional surface on titanium scaffold with both osteogenic and angiogenic properties. In this study, a biofunctional magnesium coating is deposited on porous Ti6Al4V scaffold. For osseointegration and osteogenesis analysis, in vitro studies reveal that magnesium-coated Ti6Al4V co-culture with MC3T3-E1 cells can improve cell proliferation, adhesion, extracellular matrix (ECM) mineralization and ALP activity compared with bare Ti6Al4V cocultivation. Additionally, MC3T3-E1 cells cultured with magnesium-coated Ti6Al4V show significantly higher osteogenesis-related genes expression. In vivo studies including fluorochrome labeling, micro-computerized tomography and histological examination of magnesium-coated Ti6Al4V scaffold reveal that new bone regeneration is significantly increased in rabbits after implantation. For angiogenesis studies, magnesium-coated Ti6Al4V improve HUVECs proliferation, adhesion, tube formation, wound-healing and Transwell abilities. HUVECs cultured with magnesium-coated Ti6Al4V display significantly higher angiogenesis-related genes (HIF-1α and VEGF) expression. Microangiography analysis reveal that magnesium-coated Ti6Al4V scaffold can significantly enhance the blood vessel formation. This study enlarges the application scope of magnesium and provides an optional choice to the conventional porous Ti6Al4V scaffold with enhanced osteogenesis and angiogenesis for further orthopedic applications.
CHOLANGIOSCOPY-GUIDED LITHOTRIPSY IN THE TREATMENT OF DIFFICULT BILE DUCTS STONES- DATA FROM TWO TERTIARY REFERRAL CENTERS
Authors: P Karagyozov, K El-Atrebi, I Boeva, I Tishkov
Journal: Endoscopy (2020)

Aims To evaluate the efficacy and safety of D-SOC- guided lithotripsy in cases of difficult bile ducts stones and to analyze factors, related to adverse events and procedure time.
SUCCESSFUL GASTROCUTANEOUS FISTULA CLOSURE WITH ENDOSCOPIC SUTURING SYSTEM
Authors: LD Montes, AL Fernández, M Alonso-Sierra, LP Orejana, ÁR Sánchez, F González-Panizo Tamargo, LZ Zamora, CC Blanco, CA Aranguren, EV Sequeiros, D Juzgado de Lucas
Journal: Endoscopy (2020)

73-year-old man with hypopharyngeal tumor, requiring percutaneous gastrostomy (PEG) for eleven months. After removal, the patient presented clinic of GCF (gastrointestinal content leakage and signs of infection), confirmed with computerized tomography. Sixteen months later, the fistula persisted despite infection resolution and pantoprazole. Endoscopic closure was performed, consisting in mucosal resection around the internal orifice followed by endoscopic suturing with Oversticth system, intensifying pantoprazole therapy. Two weeks later the patient showed no clinic of GCF.
A highly polarized TH2 bladder response to infection promotes epithelial repair at the expense of preventing new infections
Authors: Jianxuan Wu, Byron W. Hayes, Cassandra Phoenix, Gustavo Sosa Macias, Yuxuan Miao, Hae Woong Choi, Francis M. Hughes, J. Todd Purves, R. Lee Reinhardt, Soman N. Abraham
Journal: Nature Immunology (2020)
AUTOMATED POLYP DETECTION ON CAPSULE ENDOSCOPY USING AN INTEGRATED 2D AND 3D DEEP NEURAL NETWORK
Authors: A Bobade, S Yi, FC Ramirez, JA Leighton, SF Pasha
Journal: Endoscopy (2020)

Aims We report an integrated CNN framework that utilizes color and depth (3D) information for automated polyp detection. Our goal is to demonstrate advantages gained by adding 3D information.
AN UNCOMMON RETROPERITONEAL GANGLIONEUROMA DIAGNOSED BY ENDOSCOPIC ULTRASOUND GUIDED FINE NEEDLE ASPIRATION (EUS-FNA)
Authors: B Agudo, M González-Haba, JP Ortega, E Tejerina, JS Miguel, JL Calleja
Journal: Endoscopy (2020)

A 72-year-old patient was referred for one-year intermittent abdominal pain. Abdominal ultrasound showed a 7.3 × 7.7 cm retroperitoneal mass, which partially compressed the inferior cava vein. Radiological imaging demonstrated a retropancreatic lesion, heterogeneous, with well-defined edges, without clear dependence of any adjacent structure. Cytological diagnosis of ganglioneuroma was made by EUS-FNA. The immunohistochemistry in the resection specimen revealed confirmed the previous finding. Ganglioneuromas are rare benign tumors, diagnosis is based on pathology and complete surgical resection is the treatment of choice.
Treatment of Migraine
Authors: Arnold P. Friedman
Journal: New England Journal of Medicine (1954)

THE treatment of migraine has posed a problem for over two thousand years. Its severity and the tenacity of the symptoms have caused much concern to doctor and patient alike.If the physician who approaches the therapy of migraine follows the inflexible "one-treatment" attitude, he will find his chance of success greatly limited. Reading the various reports in the literature, he is confronted with a multiplicity of theories about the cause of migraine and finds a regimen affixed to each hypothesis. Treatments based on various theories are remarkable for their consistent therapeutic success as well as their inconsistencies. For example, . . .
Bronchial Rheoplasty for Treatment of Chronic Bronchitis. Twelve-Month Results from a Multicenter Clinical Trial
Authors: Arschang Valipour, Sebastian Fernandez-Bussy, Alvin J. Ing, Daniel P. Steinfort, Gregory I. Snell, Jonathan P. Williamson, Tajalli Saghaie, Louis B. Irving, Eli J. Dabscheck, William S. Krimsky, Jonathan Waldstreicher
Journal: American Journal of Respiratory and Critical Care Medicine (2020)

Chronic bronchitis (CB) is characterized by productive cough with excessive mucus production, resulting in quality-of-life impairment and increased exacerbation risk. Bronchial rheoplasty uses an endobronchial catheter to apply nonthermal pulsed electrical fields to the airways. Preclinical studies have demonstrated epithelial ablation followed by regeneration of normalized epithelium.
Political reverence towards the NHS is a smokescreen
Authors: Mark Prince
Journal: BMJ (2020)

It is the nature of politics to be fickle.1 Branded unprofessional and lacking vocation four years ago by the then health secretary, junior doctors are now exalted, along with our consultant and nursing colleagues, as NHS heroes. Furthermore, we are now showered with an assortment of additional benefits, ranging from priority supermarket access to free car breakdown cover.

It is easy to argue that, as frontline NHS workers, we deserve any recognition that …
Opportunities for Research for COVID-19 in the Mission of NIDDK
Authors: William T. Cefalu, Stephen P. James, Robert A. Star
Journal: Diabetes Care (2020)

The current worldwide pandemic of the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to cause incredible morbidity and mortality on a global level. Presently, there is no effective pharmacologic therapy nor a vaccine to offer. Given the circumstances and mode of transmission, the coronavirus crisis is expected to remain a significant part of our lives for the foreseeable future, continuing to cause economic hardships, straining our health care system, and changing the way we work and live on a daily basis. From this crisis, we have learned, and will continue to learn, new information almost daily. What we did know prior to the pandemic was that past viral pandemics have clearly demonstrated the association of chronic disease comorbidities with increased risk for morbidity and mortality (1–3). This observation is no different with the current crisis, as a number of chronic diseases appear to be important comorbidities in those with COVID-19 infection (3,4). As recently reported, during 1–30 March 2020, 89.3% of hospitalized adults had one or more underlying conditions. The most commonly reported conditions overall were hypertension (49.7%), obesity (48.3%), chronic lung disease (34.6%), diabetes (28.3%), cardiovascular disease (27.8%), and kidney disease (13.1%) (4), several of which fall within National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) mission areas. It is important from a medical perspective that we fully understand the clinical characteristics of individuals affected, risk factors for mortality and other outcomes, potential underlying health disparities, and other clinical variables in order to be in the best position as a medical community to inform on mitigation strategies and treatment until a vaccine is found.

At present, clinicians managing patients with acute onset of multisystem dysfunction must make urgent decisions with little evidence to guide their practice. …
Evaluation of the Performance of a Point-of-Care Test for Chlamydia and Gonorrhea
Authors: Barbara Van Der Pol, Stephanie N. Taylor, Leandro Mena, Joel Lebed, Candice Joy McNeil, LaShonda Crane, Aaron Ermel, Adam Sukhija-Cohen, Charlotte A. Gaydos
Journal: JAMA Network Open (2020)

<h3>Importance</h3> Rates of chlamydial and gonococcal infection continue to increase in the United States, as do the associated costs of untreated infections. Improved diagnostic technologies that support testing and treating in 1 clinical visit are critical to advancing efforts to control the rates of chlamydial and gonococcal infection. <h3>Objective</h3> To evaluate the clinical performance of a point-of-care (POC) molecular diagnostic assay for the detection of chlamydia and gonorrhea. <h3>Design, Setting, and Participants</h3> A noninterventional, cross-sectional clinical study was conducted from September 18, 2018, through March 13, 2019, at sexually transmitted infection (STI), HIV, family planning, and obstetrics and gynecology clinics where STI screening is routine, using a convenience sample and comparing commercially available assays with a new 30-minute POC assay. Patients included were those eligible for STI screening or diagnostic testing who had not taken antibiotics effective against chlamydia or gonorrhea within the previous 28 days. Four vaginal swab samples were collected from women and a first-catch urine sample was obtained from men. <h3>Main Outcomes and Measures</h3> A composite infection status was used to classify participants as infected if 2 or more comparator results were positive, as not infected if 2 or more comparator samples were negative, and as unevaluable if 1 result was invalid and the other 2 results did not agree with each other. <h3>Results</h3> Swab samples from 1523 women (median age, 27 years [interquartile range, 17-37 years]), 817 (53.6%) of whom presented with symptoms, and 922 men (median age, 29 years [interquartile range, 17-41 years]), 308 (33.4%) of whom were symptomatic, were tested. For chlamydia, sensitivity of the new POC assay was 96.1% (95% CI, 91.2%-98.3%) for women and 92.5% (95% CI, 86.4%-96.0%) for men. For gonorrhea, sensitivity estimates were 100.0% (95% CI, 92.1%-100.0%) for women and 97.3% (95% CI, 90.7%-99.3%) for men. For chlamydia, specificity of the new POC assay was 99.1% (95% CI, 98.4%-99.5%) for women and 99.3% (95% CI, 98.4%-99.7%) for men. For gonorrhea, specificity estimates were 99.9% (95% CI, 99.5%-100%) for women and 100% (95% CI, 95.5%-100%) for men. Non–laboratory-trained personnel performed 94.8% of all tests (2318 of 2445) during the study. <h3>Conclusions and Relevance</h3> This study suggests that self-obtained vaginal swab samples were associated with performance equivalent to laboratory-based molecular diagnostics, which can support use of this POC assay in many settings. The availability of an easy-to-use, rapid (30-minute) molecular test for accurate detection of chlamydia and gonorrhea has the power to facilitate testing and treatment in a single patient visit for these STIs.
Response to: “Reply to ‘Varicella-like exanthem as a specific COVID-19-associated skin manifestation: multicenter case series of 22 patients’: To consider varicella-like exanthem associated with COVID-19, virus varicella zoster and virus herpes simplex must be ruled out”
Authors: Angelo Valerio Marzano, Giovanni Genovese
Journal: Journal of the American Academy of Dermatology (2020)
ERCP FOR THE TREATMENT OF BILIARY COMPLICATIONS FOLLOWING CHOLECYSTECTOMY
Authors: C Konstantakis, G Diamantopoulou, G Theocharis, M Kalafateli, T Lourida, S Georgios, I Kehagias, C Triantos, K Thomopoulos
Journal: Endoscopy (2020)

Aims The purpose of this study is to evaluate the usefulness and efficacy of endoscopic treatment of biliary complications in patients undergoing cholecystectomy, as illustrated by decades of data.
DUODENAL CANCER COMPLICATED WITH BILIARY STRICTURE, DUODENAL OBSTRUCTION AND ACUTE CHOLECYSTITIS TREATED WITH BILIARY STENTING, EUS-GUIDED GASTROJEJUNOSTOMY AND EUS-GUIDED CHOLECYSTOGASTROSTOMY
Authors: M Lajin
Journal: Endoscopy (2020)

A 66-year-old female with duodenal cancer invading the mesenteric vessels presented with biliary and duodenal obstruction at segment D3. She underwent ERCP with biliary stenting. Following that, Balloon-assisted/EUS-guided Gastrojejunostomy was performed using a 2 cm LAMS. She was discharged soft diet.
FEASIBILITY OF ENTERAL STENTS WITH A NEW METHOD FOR MALIGNANT OBSTRUCTION IN RT SIDE COLON
Authors: CB Ryu, MS Lee, JY Bae
Journal: Endoscopy (2020)

Aims This study aimed to (1) investigate the effectiveness of SEMS insertion for right-sided obstructive colon cancer compared to conventional decompression tube placement and (2) confirm the safety and technical success of SEMS insertion in the right colon compared to left-sided SEMS insertion.
Middermal Elastolysis—A Possible End Stage of Granuloma Annulare
Authors: Lieke C. J. van Delft, Myrurgia Abdul Hamid, Frank S. van Leersum
Journal: JAMA Dermatology (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue
Special international consensus and systematic review issue: hips, tendons, shoulders, knees, backs, Ramadan and coffee!
Authors: Karim M Khan
Journal: British Journal of Sports Medicine (2020)

What is in this issue of BJSM for you? We usually highlight one or two papers on a cover but we had to include six this time, as the quality was just too high to overlook any! (figure 1). While on the cover … a shout out to medical artist Vicky Earle (Canada, @EarleArt) on her 12th anniversary as BJSM cover artist. Thank you!



Figure 1 
Cam lesion as described in the femoroacetabular impingement—one element of the femoroacetabular (FAI) syndrome . 



The best and brightest share their consensus with clinicians who treat hip pain and tendon pain. Hip-related pain—emanating from conditions such as femoroacetabular impingement syndrome (cam lesion in figure 1), acetabular dysplasia or labral tears—carries a very large burden of disease. Over 40 physiotherapists, sport and exercise medicine physicians and other hip-pain experts spent a year preparing for a November (2018) weekend of vigorous discussion in Zurich at the world-famous Schultess Clinic. Check out one of the four Consensus Statements in this issue …
Socioeconomic Differences in the Epidemiologic Transition From Heart Disease to Cancer as the Leading Cause of Death in the United States, 2003 to 2015
Authors: Katherine G. Hastings, Derek B. Boothroyd, Kristopher Kapphahn, Jiaqi Hu, David H. Rehkopf, Mark R. Cullen, Latha Palaniappan
Journal: Annals of Internal Medicine (2018)

Recent studies of state-level data suggest that the United States is transitioning from heart disease to cancer as the leading cause of death. This analysis provides data on this “new epidemiologic...
The screw tip stent retriever for biliary drainage in a severe living donor liver transplant anastomotic stricture
Authors: Abdul Kouanda, Patrick Avila, Mustafa Arain
Journal: Endoscopy (2020)

The screw tip stent retriever (STSR) is an endoscopic device that allows for removal of biliary and pancreatic duct stents while maintaining guidewire placement. A few case reports of patients with biliary strictures in whom standard dilation techniques have failed have described success of the STSR for dilating and traversing high grade benign and malignant strictures [1] [2] [3]. In this video case report ([Video 1]), we show that it can also be used in living donor liver transplant (LDLT) recipients with high grade strictures and relatively small upstream intrahepatic bile ducts.
Abstract 470: Understanding the Distribution of CPR Training in Pennsylvania High Schools
Authors: Paige Meskers, Vanessa Mejia, Jessica Salerno, Leonard Weiss, David D Salcido
Journal: Circulation (2019)

Introduction: Bystander CPR may increase out-of-hospital cardiac arrest survival rates. Incorporating CPR education into high school curricula is an efficient way to teach a large number of individuals CPR. Pennsylvania, unlike most states, does not require CPR training prior to graduation, and the prevalence of school training programs is not known. Objective: The goal of this study was to describe the distribution and characteristics of CPR training practices in high schools across Pennsylvania. Methods: As part of an ongoing public health project, we developed and administered a 7-question survey designed to determine if school districts offer CPR training programs, and if so, query key details about those programs. Using the Pennsylvania Education Names and Addresses database, we compiled contact information for all Pennsylvania school districts. Student researchers then contacted district personnel by telephone or email to administered the survey. Survey results were tabulated and summarized, and basic comparative statistics were calculated using Stata (ver. 15). Geographic patterns were assessed using QGIS (ver. 3.0.1) To understand the role of race and economics in availability of CPR training, our analyses incorporated census data on median income, race and ethnicity. Results: Between July 2018 and May 2019, we attempted to contact all 500 school districts in Pennsylvania, 494 of which were determined to have high schools within the district. We received survey responses from 446 (90%) school districts. Of those, 255 (57%) offered some form of CPR education and 141 (32%) of those programs were mandatory. Of the 255 districts that offered programs, 157 (62%) programs certified students as CPR providers. School districts that have CPR training have a median household income on average $4906 higher than school districts without CPR training. Clusters of districts with and without training were observed, however these clusters did not correlate with state geographic divisions, white race or Hispanic ethnicity. Conclusion: In Pennsylvania, where CPR training is not mandatory in high schools, at least half of all schools have training programs. Factors determining program adoption are unclear.
TC-325 (HEMOSPRAY) IN NON VARICEAL ACUTE UPPER GASTROINTESTINAL BLEEDING: A SINGLE CENTRE EXPERIENCE
Authors: R Sundramoorthi, G Walker, M Hanna
Journal: Endoscopy (2020)

Aims TC-235 (Hemospray) is a haemostatic powder licensed for the treatment of non-variceal upper gastrointestinal bleeding (NVUGIB). The objective of this study was to assess the use and effectiveness of Hemospray at our centre, as well as attempt to establish potential risk factors for failure to achieve haemostasis.