tbuckley/cabot-search huggingface dataset:
NEIGHBORHOOD SOCIOECONOMIC STATUS AND DIFFERENCES IN TRANSPLANT-FREE SURVIVAL, NEURODEVELOPMENT, AND HEALTH-RELATED QUALITY OF LIFE IN CHILDREN WITH SINGLE VENTRICLE HEART DISEASE: RESULTS FROM THE PEDIATRIC HEART NETWORK (PHN) SINGLE VENTRICLE RECONSTRUCTION (SVR) STUDY
Authors: Emily Bucholz, Lynn Sleeper, Caren Goldberg, Sara Pasquali, Brett Anderson, J. William Gaynor, James Frank Cnota, Jane W. Newburger
Journal: Journal of the American College of Cardiology (2020)
MODE OF DEATH IN PATIENTS WITH HEART FAILURE AND LEFT VENTRICULAR EJECTION FRACTION≥45%: INSIGHTS FROM PARAGON-HF
Authors: Akshay S. Desai, John Cleland, Muthiah Vaduganathan, Brian Claggett, Ebrahim Barkoudah, Peter V. Finn, Finnian McCausland, Mehmet B. Yilmaz, Martin Lefkowitz, Victor Shi, Marc A. Pfeffer, John McMurray, Scott D. Solomon
Journal: Journal of the American College of Cardiology (2020)
ARTIFICIAL INTELLIGENCE BASED FULLY AUTOMATED MYOCARDIAL FUNCTION ASSESSMENT FOR DIAGNOSTIC AND PROGNOSTIC STRATIFICATION FOLLOWING MYOCARDIAL INFARCTION
Authors: Andreas Schuster, Torben Lange, Sören J. Backhaus, Carolin Strohmeyer, Jonas Matz, Johannes Kowallick, Joachim Lotz, Michael Steinmetz, Shelby Kutty, Boris Bigalke, Matthias Gutberlet, Gerd Hasenfuß, Holger Thiele, Thomas Stiermaier, Ingo Eitel
Journal: Journal of the American College of Cardiology (2020)
Preoteomic insights in oncology: What have we learned from measuring millions of proteins?
Authors: Ed Brody, Trudi Foreman, Rosalynn D Gill, Mike Mehan, Malti Nikrad, Rachel Ostroff, Alex Stewart, Steve Williams, Dom Zichi
Journal: Journal of Clinical Oncology (2012)

e21142 Background: We have assayed over 8400 blood samples from 10 different malignancies, generating over 8 million quantitative protein measurements using SOMAscan, a new proteomic assay based on modified aptamers. It is capable of simultaneously measuring more than a thousand proteins from small volumes of biological samples such as plasma, tissues or cells. Methods: Bioinformatic analysis has revealed biomarker panels for early detection, differential diagnosis or prognosis in 6 of these cancers: lung, mesothelioma, ovarian, pancreatic, bladder, and renal cell carcinoma. Individual classifiers have been built with 7-13 biomarkers and AUC ranges of 0.84-0.99. These analyses have revealed unique biomarkers for each cancer, as well as common markers. Results: Several themes emerge from our extensive survey of oncology proteomic profiles. Many of the proteins correlate with disease burden or histopathological grade, and thus have utility for diagnosis, prognosis and recurrence monitoring. Parallels between serum and lung tumor tissue protein measurements demonstrate that many of the blood biomarkers arise from the tumor environment. Inflammatory response proteins are identified in many cancers and reveal important connections between tumor development and host response. Patterns can be found for biological processes in tumor biology, including angiogenesis, apoptosis, inflammation, metabolism and tumor invasion. Conclusions: With this new proteomics technology – which is fast, economical, highly scalable and flexible – we now have a powerful tool that enables proteome-wide proteomics, biomarker discovery and advancing the next generation of evidence-based, “personalized” diagnostics and therapeutics for oncology.
THIRTY DAY UNPLANNED READMISSION IN PATIENTS OLDER THAN 80 YEARS AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Sandipan Chakraborty, Birendra Amgai, Dhrubajyoti Bandyopadhyay, Neelkumar Patel, Soniya Koirala, Zeel Patel, Wilbert Aronow
Journal: Journal of the American College of Cardiology (2020)
The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak – an update on the status
Authors: Yan-Rong Guo, Qing-Dong Cao, Zhong-Si Hong, Yuan-Yang Tan, Shou-Deng Chen, Hong-Jun Jin, Kai-Sen Tan, De-Yun Wang, Yan Yan
Journal: Military Medical Research (2020)

Abstract An acute respiratory disease, caused by a novel coronavirus (SARS-CoV-2, previously known as 2019-nCoV), the coronavirus disease 2019 (COVID-19) has spread throughout China and received worldwide attention. On 30 January 2020, World Health Organization (WHO) officially declared the COVID-19 epidemic as a public health emergency of international concern. The emergence of SARS-CoV-2, since the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, marked the third introduction of a highly pathogenic and large-scale epidemic coronavirus into the human population in the twenty-first century. As of 1 March 2020, a total of 87,137 confirmed cases globally, 79,968 confirmed in China and 7169 outside of China, with 2977 deaths (3.4%) had been reported by WHO. Meanwhile, several independent research groups have identified that SARS-CoV-2 belongs to β-coronavirus, with highly identical genome to bat coronavirus, pointing to bat as the natural host. The novel coronavirus uses the same receptor, angiotensin-converting enzyme 2 (ACE2) as that for SARS-CoV, and mainly spreads through the respiratory tract. Importantly, increasingly evidence showed sustained human-to-human transmission, along with many exported cases across the globe. The clinical symptoms of COVID-19 patients include fever, cough, fatigue and a small population of patients appeared gastrointestinal infection symptoms. The elderly and people with underlying diseases are susceptible to infection and prone to serious outcomes, which may be associated with acute respiratory distress syndrome (ARDS) and cytokine storm. Currently, there are few specific antiviral strategies, but several potent candidates of antivirals and repurposed drugs are under urgent investigation. In this review, we summarized the latest research progress of the epidemiology, pathogenesis, and clinical characteristics of COVID-19, and discussed the current treatment and scientific advancements to combat the epidemic novel coronavirus.
IMPACT OF POST PROCEDURAL ANTI-COAGULATION ON POST PROCEDURAL COMPLICATIONS AND DEVICE RELATED THROMBUS IN WATCHMAN PATIENTS: A MULTI-CENTER EXPERIENCE
Authors: Nachiket Madhav Apte, Aman Patel, Gregory Jackson, Arslan Naeem, Lance Longmore, Michael Pierpoline, Amit Shrestha, Matthew Earnest, Seth H. Sheldon, Senthil Thambidorai, Arvindh Kanagasundram, Christopher R. Ellis, Madhu Reddy
Journal: Journal of the American College of Cardiology (2020)
Aggressive case of early onset gastric cancer; identifying the knowledge gap
Authors: Jennifer M Kolb, Stephen Leong, Lindsey M Westbrook, Swati G Patel
Journal: Gut (2020)

A woman aged 30 years was referred for endoscopy for iron deficiency anaemia. Colonoscopy was normal. Upper endoscopy demonstrated multiple small, carpet-like, sessile polyps in the gastric fundus and a larger 4 cm polyp in the body (figure 1). The duodenum was normal without polyps. Endoscopic ultrasound demonstrated a 35×36 mm hypoechoic polypoid lesion arising from the mucosa and invading into the submucosa, but with well-defined borders suggesting lack of invasion into adjacent structures. Endoscopic mucosal resection was performed on a portion of this polyp for histology. Pathology showed a focus of high-grade dysplasia arising in hyperplastic polyp. Her mother and maternal grandmother had gastric cancer, and her sister had gastric polyps and a non-melanoma skin cancer. The patient underwent a laparoscopic total gastrectomy and surgical pathology demonstrated a poorly differentiated adenocarcinoma with 23 negative lymph nodes, stage pT1bN0M0 (figure 2). No adjuvant therapy was recommended, and surveillance CT scan at …
DISTRIBUTION OF CORONARY ARTERY CALCIUM (CAC) SCORES IN CERTIFIED BLUE ZONES OF CALIFORNIA
Authors: Suvasini Lakshmanan, April Kinninger, Suraj Dahal, Afiachukwu Onuegbu, Andrew Cai, Divya Birudaraju, Sajad Hamal, Sion K. Roy, Matthew J. Budoff
Journal: Journal of the American College of Cardiology (2020)
Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway
Authors: Chunyong Ding, Zilan Song, Ancheng Shen, Tingting Chen, Ao Zhang
Journal: Acta Pharmaceutica Sinica B (2020)

Multiple cancer immunotherapies including chimeric antigen receptor T cell and immune checkpoint inhibitors (ICIs) have been successfully developed to treat various cancers by motivating the adaptive anti-tumor immunity. Particularly, the checkpoint blockade approach has achieved great clinic success as evidenced by several U.S. Food and Drug Administration (FDA)-approved anti-programmed death receptor 1/ligand 1 or anti-cytotoxic T lymphocyte associated protein 4 antibodies. However, the majority of cancers have low clinical response rates to these ICIs due to poor tumor immunogenicity. Indeed, the cyclic guanosine monophosphate-adenosine monophosphate synthase‒stimulator of interferon genes‒TANK-binding kinase 1 (cGAS‒STING‒TBK1) axis is now appreciated as the major signaling pathway in innate immune response across different species. Aberrant signaling of this pathway has been closely linked to multiple diseases, including auto-inflammation, virus infection and cancers. In this perspective, we provide an updated review on the latest progress on the development of small molecule modulators targeting the cGAS‒STING‒TBK1 signaling pathway and their preclinical and clinical use as a new immune stimulatory therapy. Meanwhile, highlights on the clinical candidates, limitations and challenges, as well as future directions in this field are also discussed. Further, small molecule inhibitors targeting this signaling axis and their potential therapeutic use for various indications are discussed as well.
Multimodality treatment of pediatric and adult patients with Ewing sarcoma: A single-institution experience.
Authors: David Lorente, Robert Diaz, Barbara Torres, Adela Cañete, Jorge Aparicio, Alejandra Gimenez, Encarni Reche, Esteban Rodrigo, Amparo Verdeguer, Joaquin Montalar
Journal: Journal of Clinical Oncology (2012)

10082 Background: Treatment of Ewing sarcoma pts. usually follows pediatric protocols, both in children and in adults. However, older patients fare poorly in most series. We analyze our experience with the 2001 protocol of the Spanish Society of Pediatric Oncology. Methods: Retrospective analysis. Schema: 6 cycles (cy) of VIDE chemotherapy (CT: vincristine, ifosfamide, etoposide, doxorrubicin). If no progression, local treatment (surgery or RT) and consolidation adjusted to risk: VACx8 (vincristine, dactinomycin, ciclophosphamyde) in standard-risk pts; if increased risk (axial, complete response in lung metastases or non-pulmonary metastases) VACx1, high-dose CT (busulphan-melphalan) and autologous transplant (ATSP). Analysis: induction CT toxicity, pathological response rates, consolidation treatment, disease-free (DFS) and overall survival (OS) (Kaplan- Meier). Log-rank and Cox regression analysis of prognostic factors in OS. Results: 35 patients (01.2003-05.2011). 60% male. Median age 16 y (r 7-57). Axial (43%), extremities (34%), extra-osseous (18%) and ribs (9%). Metastases: 54% (lung 58%, bone 26%, others 12%). &gt; 1 location: 29%. Induction CT: 83% received 6 cy. 6% early progressions and 3% toxic deaths. 196 cycles of CT. Dose reduction (etoposide) in 60%. Grade 3-4 toxicity: neutropenia 13%, anemia 14%, neutropenic fever 13%, diarrhoea-stomatitis 7%.Local treatment: surgery (49%), radiotherapy (29%), none (22%). In 17 resections, &gt; 90% necrosis in 53%. Consolidation: VACx8 29%; VACx1-ATSP in 34%; 37% other treatments (progression). No ATSP-related mortality. Median follow-up: 36 m ( 5-101 m). Median DFS 25 m (16-34 m). Median OS 28 m (15-41 m), 3-year OS 40%. Median time to progression 7 m (0.4-15 m). Median OS from progression 7 m (0.4-15 m). Age &lt; 15 years, a non-axial primary and no extra-pulmonary metastases were favourable prognostic factors in the univariate analysis. Conclusions: Induction CT with the VIDE regimen is feasible in most patients, with a low risk of early progression. Hematological toxicity is substantial but manageable. Adults patients have a worse prognosis compared to pediatric patients. Unfortunately, survival after progression is dismal.
TRICUSPID AND MITRAL REMODELING IN ATRIAL FIBRILLATION: A THREE-DIMENSIONAL ECHOCARDIOGRAPHIC STUDY
Authors: Xochitl Ortiz-Leon, Edith Posada, Maria Trejo, Juan Betuel Ivey Miranda, Jason Pereira, Ian Crandall, Paul DaSilva, Eileen Bouman, Alyssa Brooks, Christine Gerardi, Helene Houle, Joseph Akar, Ben A. Lin, Robert McNamara, Bernardo Lombo, José Antonio Arias-Godínez, Lissa Sugeng
Journal: Journal of the American College of Cardiology (2020)
Delayed Identification of Infants Who Are Deaf or Hard of Hearing — Minnesota, 2012–2016
Authors: Abby C. Meyer, Melinda Marsolek, Nicole Brown, Kirsten Coverstone
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

Using the findings from this report to develop public health initiatives that target certain populations could improve timely identification, reduce the risk for language delay, and enhance outcomes in children who are deaf or hard of hearing.
REAL WORLD STUDY OF CHARACTERISTICS AND OUTCOMES OF COMMERCIALLY INSURED PATIENTS WITH STABLE VERSUS WORSENING CHRONIC HEART FAILURE WITH REDUCED EJECTION FRACTION
Authors: Javed Butler, Laurence Djatche, Baanie Sawhney, Sreya Chakladar, Lingfeng Yang, Joanne Brady, Mei Yang
Journal: Journal of the American College of Cardiology (2020)
A New Role for the Aldosterone/Mineralocorticoid Receptor Pathway in the Development of Mitral Valve Prolapse
Authors: Jaime Ibarrola, Amaia Garcia-Peña, Lara Matilla, Benjamin Bonnard, Rafael Sádaba, Vanessa Arrieta, Virginia Alvarez, Amaya Fernández-Celis, Alicia Gainza, Adela Navarro, Diego Alvarez de la Rosa, Patrick Rossignol, Frederic Jaisser, Natalia López-Andrés
Journal: Circulation Research (2020)

Mitral valve prolapse (MVP) is one of the most common valvular disorders. However, the molecular and cellular mechanisms involved in fibromyxomatous changes in the mitral leaflet tissue have not been elucidated. Aldosterone (Aldo) promotes fibrosis in myocardium, and MR (mineralocorticoid receptor) antagonists (MRAs) improve cardiac function by decreasing cardiac fibrosis.We investigated the role of the Aldo/MR in the fibromyxomatous modifications associated with MVP.Aldo enhanced valvular interstitial cell activation markers and induced endothelial-mesenchymal transition in valvular endothelial cells, resulting in increased proteoglycan secretion. MRA blocked all the above effects. Cytokine arrays showed CT-1 (cardiotrophin-1) to be a mediator of Aldo-induced valvular interstitial cell activation and proteoglycan secretion and CD (cluster of differentiation) 14 to be a mediator of Aldo-induced endothelial-mesenchymal transition and proteoglycan secretion in valvular endothelial cells. In an experimental mouse model of MVP generated by nordexfenfluramine administration, MRA treatment reduced mitral valve thickness and proteoglycan content. Endothelial-specific MR deletion prevented fibromyxomatous changes induced by nordexfenfluramine administration. Moreover, proteoglycan expression was slightly lower in the mitral valves of MVP patients treated with MRA.These findings demonstrate, for the first time, that the Aldo/MR pathway regulates the phenotypic, molecular, and histological changes of valvular interstitial cells and valvular endothelial cells associated with MVP development. MRA treatment appears to be a promising option to reduce fibromyxomatous alterations in MVP.
REFRACTORY HEART FAILURE-A RARE CASE OF CONCOMINANT RIGHT AND LEFT-SIDED CARCINOID HEART DISEASE IN THE SETTING OF SELECTIVE SERETONIN RECEPTOR INHIBITOR USE
Authors: Jennifer Bell, Maad Alhudairy, Vera Kazakova, Lana Tsao, Michael Johnstone
Journal: Journal of the American College of Cardiology (2020)
Endosonography-guided gallbladder drainage versus percutaneous cholecystostomy in very high-risk surgical patients with acute cholecystitis: an international randomised multicentre controlled superiority trial (DRAC 1)
Authors: Anthony Y B Teoh, Masayuki Kitano, Takao Itoi, Manuel Pérez-Miranda, Takeshi Ogura, Shannon Melissa Chan, Carlos Serna-Higuera, Shunsuke Omoto, Raul Torres-Yuste, Takayoshi Tsuichiya, Ka Tak Wong, Chi-Ho Leung, Philip Wai Yan Chiu, Enders Kwok Wai Ng, James Yun Wong Lau
Journal: Gut (2020)

Objective The optimal management of acute cholecystitis in patients at very high risk for cholecystectomy is uncertain. The aim of the current study was to compare endoscopic ultrasound (EUS)-guided gallbladder drainage (EUS-GBD) to percutaneous cholecystostomy (PT-GBD) as a definitive treatment in these patients under a randomised controlled trial. Design Consecutive patients suffering from acute calculous cholecystitis but were at very high-risk for cholecystectomy were recruited. The primary outcome was the 1-year adverse events rate. Secondary outcomes include technical and clinical success, 30-day adverse events, pain scores, unplanned readmissions, re-interventions and mortalities. Results Between August 2014 to February 2018, 80 patients were recruited. EUS-GBD significantly reduced 1 year adverse events (10 (25.6%) vs 31 (77.5%), p&lt;0.001), 30-day adverse events (5 (12.8%) vs 19 (47.5%), p=0.010), re-interventions after 30 days (1/39 (2.6%) vs 12/40 (30%), p=0.001), number of unplanned readmissions (6/39 (15.4%) vs 20/40 (50%), p=0.002) and recurrent cholecystitis (1/39 (2.6%) vs 8/40 (20%), p=0.029). Postprocedural pain scores and analgesic requirements were also less (p=0.034). The technical success (97.4% vs 100%, p=0.494), clinical success (92.3% vs 92.5%, p=1) and 30-day mortality (7.7% vs 10%, p=1) were statistically similar. The predictor to recurrent acute cholecystitis was the performance of PT-GBD (OR (95% CI)=5.63 (1.20–53.90), p=0.027). Conclusion EUS-GBD improved outcomes as compared to PT-GBD in those patients that not candidates for cholecystectomy. EUS-GBD should be the procedure of choice provided that the expertise is available after a multi-disciplinary meeting. Further studies are required to determine the long-term efficacy. Trial registration number NCT02212717
PARADOXICAL INCREASE IN LEFT VENTRICULAR DIASTOLIC PRESSURE AFTER SUCCESSFUL TRANSCATHETER AORTIC VALVE REPLACEMENT IS RELATED TO POORER LONG-TERM OUTCOME IN SEVERE AORTIC STENOSIS
Authors: Jiwon Seo, Shinjeung Song, Chi Young Shim, Geu-Ru Hong, Young-Guk Ko, Myeong-Ki Hong, Jong-Won Ha
Journal: Journal of the American College of Cardiology (2020)
Reversal of anorexia with megestrol acetate (MA): Impact on quality of life (QoL) in non-metastasic lung cancer patients (pts) undergoing radiation therapy
Authors: J. Pardo, A. Mena, A. Monleon, V. Macias, J. Sole, M. Hernández, M. Macia
Journal: Journal of Clinical Oncology (2006)

18613 Background: Anorexia is a common and major problem in cancer patients. Its ethiology is multifactorial and has negative effects on pts QoL. Up to 30% of non-metastasic lung cancer pts receiving radiotherapy will develop anorexia during treatment. We conducted a randomized trial comparing the efficacy of two different doses of MA. The results of the first 130 pts included, presented at ASCO 2003, indicated that MA at doses of 600 mg/day is significantly more effective in the treatment of anorexia in these pts than low doses (320 mg/day) of MA. Here we present the results of the quality of life sub-study which purpose is to evaluate the effect of reversing anorexia in pts health related quality of life (HRQOL). Methods: From February 1999 to April 2003, 160 non-mestastatic lung cancer pts who developed anorexia during radiotherapy were randomized to receive either 320 mg/day or 600 mg/day of MA. All pts who developed anorexia filled up the EuroQuol (EQ-5D) quality of life questionnaire before treated with MA and the responders did it again when appetite was regained. The endpoint was improvement in pts HRQOL (defined as an increase &gt; 5 mm in the EQVAS score between the second and first questionnaires). Results: The analysis of the EuroQuol (EQ-5D) questionnaires of the 131 pts who responded to treatment with MA shows that 106 pts (81%) had an improvement &gt; 5 mm in the EQVAS score while 19 % did not. The difference is statistically significant (Binomial test: p &lt; 0.0001). Regarding differences between the two series, 42 pts improved in the 320 mg arm versus 64 in the 600 mg arm which is not statistically significant (Fisher test: p = 0.501). Conclusions: Our results indicate that reversal of anorexia with MA has a clinically significant improvement in HRQOL in non-metastatic lung cancer pts undergoing radiation therapy. The absence of statistically significant differences between the two series may be due to the sample size. [Table: see text] No significant financial relationships to disclose.
Association between suicide reporting in the media and suicide: systematic review and meta-analysis
Authors: Thomas Niederkrotenthaler, Marlies Braun, Jane Pirkis, Benedikt Till, Steven Stack, Mark Sinyor, Ulrich S Tran, Martin Voracek, Qijin Cheng, Florian Arendt, Sebastian Scherr, Paul S F Yip, Matthew J Spittal
Journal: BMJ (2020)

Abstract Objective To examine the association between reporting on suicides, especially deaths of celebrities by suicide, and subsequent suicides in the general population. Design Systematic review and meta-analysis. Data sources PubMed/Medline, PsychInfo, Scopus, Web of Science, Embase, and Google Scholar, searched up to September 2019. Review methods Studies were included if they compared at least one time point before and one time point after media reports on suicide; follow-up was two months or less; the outcome was death by suicide; and the media reports were about non-fictional suicides. Data from studies adopting an interrupted time series design, or single or multiple arm before and after comparisons, were reviewed. Results 31 studies were identified and analysed, and 20 studies at moderate risk of bias were included in the main analyses. The risk of suicide increased by 13% in the period after the media reported a death of a celebrity by suicide (rate ratio 1.13, 95% confidence interval 1.08 to 1.18; 14 studies; median follow-up 28 days, range 7-60 days). When the suicide method used by the celebrity was reported, there was an associated 30% increase in deaths by the same method (rate ratio 1.30, 95% confidence interval 1.18 to 1.44; 11 studies; median follow-up 28 days, range 14-60 days). For general reporting of suicide, the rate ratio was 1.002 (0.997 to 1.008; five studies; median follow-up 1 day, range 1-8 days) for a one article increase in the number of reports on suicide. Heterogeneity was large and partially explained by celebrity and methodological factors. Enhanced funnel plots suggested some publication bias in the literature. Conclusions Reporting of deaths of celebrities by suicide appears to have made a meaningful impact on total suicides in the general population. The effect was larger for increases by the same method as used by the celebrity. General reporting of suicide did not appear to be associated with suicide although associations for certain types of reporting cannot be excluded. The best available intervention at the population level to deal with the harmful effects of media reports is guidelines for responsible reporting. These guidelines should be more widely implemented and promoted, especially when reporting on deaths of celebrities by suicide. Systematic review registration PROSPERO CRD42019086559.
Long non-coding RNAs regulate drug resistance in cancer
Authors: Kaisheng Liu, Lin Gao, Xiaoshi Ma, Juan-Juan Huang, Juan Chen, Leli Zeng, Charles R. Ashby, Chang Zou, Zhe-Sheng Chen
Journal: Molecular Cancer (2020)

Abstract Chemoresistance, whether intrinsic or acquired, is a major obstacle in the treatment of cancer. The resistance of cancer cells to chemotherapeutic drugs can result from various mechanisms. Over the last decade, it has been reported that 1ong noncoding RNAs (lncRNAs) can mediate carcinogenesis and drug resistance/sensitivity in cancer cells. This article reviews, in detail, recent studies regarding the roles of lncRNAs in mediating drug resistance.