tbuckley/cabot-search huggingface dataset:
Recombinant Activated FVII (rFVIIa) Corrects Platelet Dysfunction in Hemophilic Patients: Study on Collagen and Tissue Factor Surfaces at High Shear Rates.
Authors: Raul Tonda, Ana M. Galan, Irene Lopez-Vilchez, Marcos Pino, Antonio Ordinas, Carmen Altisent, Gines Escolar
Journal: Blood (2005)
Gradual Onset of Myocardial Ischemia Results in Reduced Myocardial Infarction
Authors: Bruce R. Ito
Journal: Circulation (1995)

Background With moderate reductions in coronary blood flow, adjustments in myocardial metabolism can occur with a normalization of the imbalance between the decreased O 2 delivery and tissue O 2 demand. This state of “downregulated” metabolism is associated with reduced function and minimal irreversible injury and has been linked to myocardial hibernation. We hypothesized that (1) this process would occur when perfusion was reduced to severely ischemic levels, but only when flow declined at a slow rate rather than abruptly, and (2) this would result in blunted ischemia and reduced myocardial injury for a given period of low blood flow. Methods and Results The left anterior descending coronary artery in anesthetized open-chest pigs was cannulated and perfused with arterial blood by an extracorporeal perfusion pump. Regional function (percent segment shortening, %SS) was measured with sonomicrometry and a regional coronary vein cannulated for blood gas analysis and lactate measurements. Coronary blood flow (CBF) was reduced to 10% of control either in a step fashion (Fast Ischemia group) or gradually in a linear manner over 70 minutes (Ramp Ischemia group). In all animals, CBF was held for 60 minutes at this 10% level and then followed by 2 hours of reperfusion. In the Ramp Ischemia group, the linear fall in CBF resulted in an initial maintenance of both %SS and myocardial oxygen consumption (MV̇ o 2 ) followed by linear decreases in both variables ( r =.98 to .99) as flow fell to the 10% level. The relation of MV̇ o 2 to function was linear ( r =.99) over the entire flow range. Although %SS, MV̇ o 2 , CBF, coronary pressure, and hemodynamics during the 10% flow period were not different between groups, the increases in coronary venous lactate and P co 2 and fall in pH were blunted in the Ramp Ischemia group compared with the Fast Ischemia group. With reperfusion, a significant decrease in end-diastolic length was present only in the Fast Ischemia group. Additionally, although the region at risk was not different, infarction was markedly reduced in the Ramp Ischemia group (6.6±1.9%) compared with the Fast Ischemia group (31.4±6.9%). Conclusions These data are consistent with the hypothesis that the downregulation of myocardial metabolism with gradually decreased flow to severe levels results in reduced myocardial injury for a given period of low flow. We propose that the rate at which blood flow decreases with myocardial underperfusion is a novel determinant of infarct injury. This may have clinical implication in situations in which there is a time-dependent component to the decrease in coronary blood flow in acute ischemic events, ie, thrombus formation at a site of coronary stenosis.
Comparison of standard uptake value of 18F-FDG-PET-CT with tumour-infiltrating lymphocytes in breast cancer ≥1cm
Authors: S. Park, E.K. Min, S.J. Bae, C. Cha, D. Kim, J. Lee, Y.J. Cha, J. Jeong, S.G. Ahn
Journal: Annals of Oncology (2019)
Abstract #5106: Salvianolic acid B, a natural compound, showing anti-cancer activity by inhibiting breast cancer cell proliferation and inducing cell apoptosis
Authors: Wei Sha, Yanfei Zhou, Hongguang Ji, Liang Shan, Xiaowu Pang, Joseph Califano, Xinbin Gu
Journal: Cancer Research (2009)

Salvia miltiorrhiza Bge is a well-known Chinese herbal medicine that has been widely used to treat various disorders including inflammatory diseases and cancer. Salvianolic acid B (Sal-B) is an active depside compound isolated from Salvia miltiorrhiza Bge. Our previous work revealed that Sal-B selectively inhibits the cyclooxygenase expression in head and neck squamous cell carcinoma. In the present study, we have investigated the effect of Sal-B on cell proliferation of breast cancer using an estrogen receptor positive MCF-7-luc and an estrogen receptor negative MDA-MB-231-luc human breast cancer cell lines. Both cell lines were stably transfected with a luciferase gene construction. Cell-based bioluminescence assay demonstrated that Sal-B inhibited cell proliferation of both MCF-7-luc and MDA-MB-231-luc in a dose-dependent manner within the tested concentrations from 50 to 200 µg/ml and the IC50 for MCF-7-luc and MDA-MB-231-lu was 110 and 130 µg/ml, respectively. Further analysis using flow cytometry revealed that Sal-B actively induced tumor cell apoptosis. Percentage of apoptotic cells was increased when MDA-MB-231-luc cells treated with 50, 100 and 200 µg/ml of Sal-B for 24 hours (all P  Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 5106.
Neural codes – Necessary but not sufficient for understanding brain function
Authors: Simon R. Schultz, Giuseppe P. Gava
Journal: Behavioral and Brain Sciences (2019)

Abstract Brains are information processing systems whose operational principles ultimately cannot be understood without resource to information theory. We suggest that understanding how external signals are represented in the brain is a necessary step towards employing further engineering tools (such as control theory) to understand the information processing performed by brain circuits during behaviour.
Clinical and FDG-PET markers of immune checkpoint inhibitor (ICI) response in patients with metastatic Merkel cell carcinoma (mMCC)
Authors: A.M. Weppler, P. Bhave, P. De Ieso, M. Chua, J. Raleigh, A. Hatzimihalis, A. Gill, S. Balachander, J. Callahan, A. Pattison, A. Caneborg, G. Au Yeung, G. McArthur, R.J. Hicks, R. Tothill, S.K. Sandhu
Journal: Annals of Oncology (2019)
Clonal enrichments of Vδ2– γδ T cells in Mycobacterium tuberculosis–infected human lungs
Authors: Corinna A. Kulicke, Deborah A. Lewinsohn, David M. Lewinsohn
Journal: Journal of Clinical Investigation (2019)

Unconventional T cell subsets, including donor-unrestricted T cells (DURTs) and γδ T cells, are promising new players in the treatment and prevention of infectious diseases. In this issue of the JCI, Ogongo et al. used T cell receptor (TCR) sequencing to characterize unconventional T cell subsets in surgical lung resections and blood from Mycobacterium tuberculosis–infected (Mtb-infected) individuals with and without HIV coinfection. The study revealed highly localized expansions of γδ T cell clonotypes not previously associated with the immune response to Mtb and demonstrates the power of high-throughput analysis of the TCR repertoire directly from infected tissue. The findings contribute to our understanding of tuberculosis control and have implications for the development of both therapeutic and vaccination strategies.
Traumatic Brain Injury–Related Deaths by Race/Ethnicity, Sex, Intent, and Mechanism of Injury — United States, 2000–2017
Authors: Jill Daugherty, Dana Waltzman, Kelly Sarmiento, Likang Xu
Journal: MMWR Morbidity and Mortality Weekly Report (2019)

Traumatic brain injury (TBI) affects the lives of millions of Americans each year (1). To describe the trends in TBI-related deaths among different racial/ethnic groups and by sex, CDC analyzed death data from the National Vital Statistics System (NVSS) over an 18-year period (2000-2017). Injuries were also categorized by intent, and unintentional injuries were further categorized by mechanism of injury. In 2017, TBI contributed to 61,131 deaths in the United States, representing 2.2% of approximately 2.8 million deaths that year. From 2015 to 2017, 44% of TBI-related deaths were categorized as intentional injuries (i.e., homicides or suicides). The leading category of TBI-related death varied over time and by race/ethnicity. For example, during the last 10 years of the study period, suicide surpassed unintentional motor vehicle crashes as the leading category of TBI-related death. This shift was in part driven by a 32% increase in TBI-related suicide deaths among non-Hispanic whites. Firearm injury was the underlying mechanism of injury in nearly all (97%) TBI-related suicides among all groups. An analysis of TBI-related death rates by sex and race/ethnicity found that TBI-related deaths were significantly higher among males and persons who were American Indians/Alaska Natives (AI/ANs) than among all other groups across all years. Other leading categories of TBI-related deaths included unintentional motor vehicle crashes, unintentional falls, and homicide. Understanding the leading contributors to TBI-related death and identifying groups at increased risk is important in preventing this injury. Broader implementation of evidence-based TBI prevention efforts for the leading categories of injury, such as those aimed at stemming the significant increase in TBI-related deaths from suicide, are warranted.
Minimal Residual Disease and IKZF1 As Predictors of Relapse, and Increased Treatment Related Mortality in Down Syndrome Acute Lymphoblastic Leukemia: A Unique and Large International Matched Case-Control Study
Authors: Naomi Michels, Judith M. Boer, Marta Lopez-Yurda, Hester A. De Groot-Kruseman, Vincent van der Velden, Anthony V. Moorman, Amir Enshaei, Ajay Vora, Rosemary Sutton, Toby Trahair, Luciano Dalla-Pozza, Rob Pieters, Michel C Zwaan, Monique L. Den Boer
Journal: Blood (2019)
Subgroup Analyses of Elderly Patients Aged ≥ 70 Years in AUGMENT: A Phase III Randomized Study of Lenalidomide Plus Rituximab (R2) vs Rituximab Plus Placebo (R-Placebo) in Patients with Relapsed/Refractory (R/R) Indolent Non-Hodgkin Lymphoma (iNHL)
Authors: Marek Trněný, John P. Leonard, Huilai Zhang, Grzegorz Nowakowski, Koji Izutsu, Nathan H. Fowler, Catherine Thieblemont, Pier Luigi Zinzani, Stacey Kalambakas, Myron Czuczman, Pierre Fustier, Chengqing Wu, John G. Gribben
Journal: Blood (2019)
Abstract 14161: Long-Term Secondary Prevention With Ticagrelor for Prior Myocardial Infarction in Patients With No Coronary Stenting: A Sub-Analysis From PEGASUS TIMI 54
Authors: Remo H Furtado, Deepak L Bhatt, Philippe G Steg, Marc Cohen, Robert F Storey, Kyungah W Im, Marc S Sabatine, Marc P Bonaca
Journal: Circulation (2018)

Introduction: Prolonged dual antiplatelet therapy (DAPT) with acetylsalicylic acid (ASA) and a P2Y12 inhibitor was initially developed to reduce risk of stent thrombosis. However, data has emerged ...
Glucocorticoids Induce the Maintenance and Expansion of an Immature CFU-E Erythroid Progenitor Population in Humans
Authors: Ryan Ashley, Hongxia Yan, Nan Wang, John Hale, Brian M Dulmovits, Julien Papoin, Meagan Olive, Namrata Udeshi, Steven Carr, Adrianna Vlachos, Jeffrey Michael M Lipton, Lydie M. Da Costa, Christopher D. Hillyer, Sandrina Kinet, Naomi Taylor, Mohandas Narla, Anupama Narla, Lionel Blanc
Journal: Blood (2019)
Evolution of eGFR in chronic HCV patients receiving sofosbuvir-based or sofosbuvir-free direct-acting antivirals
Authors: Chen-Hua Liu, Mei-Hsuan Lee, Jou-Wei Lin, Chun-Jen Liu, Tung-Hung Su, Tai-Chung Tseng, Pei-Jer Chen, Ding-Shinn Chen, Jia-Horng Kao
Journal: Journal of Hepatology (2019)
Varying Estimations of Surgical Work Value Units
Authors: Faisal G. Bakaeen, Eric E. Roselli, Lars G. Svensson
Journal: JAMA Surgery (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
TCT-34 Effect of Sapien-3 Transcatheter Valve Implant on Health Status in Patients with Severe Aortic Stenosis at Intermediate Surgical Risk: Results from the PARTNER S3i Trial
Authors: Suzanne Baron, Maria Alu, Vinod Thourani, Susheel Kodali, Suzanne Arnold, Khaja Chinnakondepali, Elizabeth Magnuson, Kaijun Wang, Augusto Pichard, Vasilis Babaliaros, Isaac George, D. Craig Miller, E. Murat Tuzcu, Kevin Greason, Howard Herrmann, Craig Smith, Martin Leon, David Cohen
Journal: Journal of the American College of Cardiology (2016)
LMC conference: NHS England must apologise for “offensive report” on fraud in general practice
Authors: Elisabeth Mahase
Journal: BMJ (2019)

The BMA’s General Practitioners Committee (GPC) must raise a formal complaint with NHS England over a bribery and fraud report it published earlier this year,1 which suggested that the NHS could be losing £88m (€102m; $113m) a year because of economic crime in general practice.

The motion, which was passed unanimously at the annual LMC England conference 2019 held in London on 22 November, condemned the report, which it said had implied “widespread fraud” in …
Additional Factors in the Association of Gender and Parenthood With Conference Attendance—Reply
Authors: Miriam A. Knoll, Reshma Jagsi
Journal: JAMA Oncology (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Abstract P210: Sleep Duration and Eating Behavior in Young Adults: Project EAT
Authors: Rachel P Ogilvie, Pamela L Lutsey, Rachel Widome, Melissa N Laska, Dianne Neumark-Sztainer
Journal: Circulation (2017)

Background: Short sleep duration appears to put adults at risk for excess energy intake and obesity; less is known specifically about how sleep quantity relates to eating patterns. Objectives: We tested the association between sleep duration and eating among young adults, a group especially vulnerable to suboptimal sleep. Methods: We used data from Project EAT-III, a cross-sectional study of 1,854 racially/ethnically diverse young adults aged 20-30 from the Minneapolis/St. Paul metropolitan area. The EAT survey assessed: average sleep duration (calculated via weekday and weekend bedtimes and wake times), breakfast skipping, fast food, energy drink, and sport drink consumption. A food frequency questionnaire queried intake of sugar-sweetened, sugar-free, and caffeinated beverages. Linear and logistic regression, adjusted for demographic and behavioral covariates, were used to model the relationship between sleep duration and dietary outcomes. In logistic models, post-estimation commands were used to calculate risk ratios. Results: In linear models, participants who slept &amp;lt; 7 hours per night (11.5%) consumed significantly more caffeinated beverages relative to those who slept 7-8 hours per night (Table). In logistic models, those who slept 8-9 hours a night (26.6%) and &amp;gt; 9 hours per night (25.8%) reported a lower risk (0.85 (95% CI 0.70-0.99) and 0.80 (95% 0.63-0.98), respectively) of sports drink consumption, compared to those who slept 7-8 hours a night. Intake of sugar sweetened beverages, sugar-free beverages, energy drinks, breakfast, and fast food did not differ significantly by sleep duration. Conclusions: Sleep duration was related to some eating behaviors associated with energy imbalance, but not all. The impact of sleep insufficiency during young adulthood, a pivotal period in the life course, may set lifelong trajectories that may increase cardiovascular risk. Sleep may be an important target to include in interventions and policies aimed at cardiometabolic risk management.
A pilot study on comparative efficacy of tramadol or eutectic mixture of local anaesthetics (prilocaine plus lignocaine) in preventing bone marrow aspiration associated pain
Authors: B. Sansar, A. Rudresha, D. Lokanatha, L.A. Jacob, M. Sureshbabu, K. Lokesh, L. Rajeev, S. Smitha, S. Goyal, S.A. Hassan
Journal: Annals of Oncology (2019)
Expanding CAR T cells in human platelet lysate renders T cells with in vivo longevity
Authors: Alejandro Torres Chavez, Mary Kathryn McKenna, Emanuele Canestrari, Christina T. Dann, Carlos A. Ramos, Premal Lulla, Ann M. Leen, Juan F. Vera, Norihiro Watanabe
Journal: Journal for ImmunoTherapy of Cancer (2019)

<h3>Background</h3> Pre-clinical and clinical studies have shown that the infusion of CAR T cells with a naive-like (T<sub>N</sub>) and central memory (T<sub>CM</sub>) phenotype is associated with prolonged in vivo T cell persistence and superior anti-tumor effects. To optimize the maintenance of such populations during the in vitro preparation process, we explored the impact of T cell exposure to both traditional [fetal bovine serum (FBS), human AB serum (ABS)] and non-traditional [human platelet lysate (HPL) - a xeno-free protein supplement primarily used for the production of clinical grade mesenchymal stromal / stem cells (MSCs)] serum supplements. <h3>Methods</h3> Second generation chimeric antigen receptor with CD28 and CD3ζ endodomain targeting prostate stem cell antigen (PSCA) (P28z) or CD19 (1928z) were constructed and used for this study. After retroviral transduction, CAR T cells were divided into 3 conditions containing either FBS, ABS or HPL and expanded for 7 days. To evaluate the effect of different sera on CAR T cell function, we performed a series of in vitro and in vivo experiments. <h3>Results</h3> HPL-exposed CAR T cells exhibited the less differentiated T cell phenotype and gene signature, which displayed inferior short-term killing abilities (compared to their FBS- or ABS-cultured counterparts) but superior proliferative and anti-tumor effects in long-term in vitro coculture experiments. Importantly, in mouse xenograft model, HPL-exposed CAR T cells outperformed their ABS or FBS counterparts against both subcutaneous tumor (P28z T cells against Capan-1<sup>PSCA</sup>) and systemic tumor (1928z T cells against NALM6). We further observed maintenance of less differentiated T cell phenotype in HPL-exposed 1928z T cells generated from patient's PBMCs with superior anti-tumor effect in long-term in vitro coculture experiments. <h3>Conclusions</h3> Our study highlights the importance of serum choice in the generation of CAR T cells for clinical use.
Anti-tumor activity of non-benzoquinone ansamycin Hsp90 inhibitors in murine xenograft models
Authors: Thomas-Toan Tran, Hugo Menzella, Chris Reeves, Sumati Murli, Sara Eng, Lee-Juian Lin, Ziyang Zhong, Pieter Timmermans, Gary Ashley
Journal: Cancer Research (2008)

5630  Hsp90 is a protein chaperone that acts to stabilize and/or activate a number of proteins required for cellular signaling pathways, including several known determinants of carcinogenesis such as Her2 (ErbB2), B-Raf, c-Kit, Flt-3, and Raf-1. Hsp90 is effectively inhibited by benzoquinone ansamycins, such as geldanamycin, herbimycin, macbecin, and their derivatives, which bind to the ATP binding site in the N-terminal domain. Recent results from clinical trials using the geldanamycin derivatives tanespimycin (17-AAG) and alvespimycin (17-DMAG) suggest that inhibition of Hsp90 could be an important therapeutic mechanism for the treatment of cancer. We have previously reported the production of non-benzoquinone ansamycin Hsp90 inhibitors using genetic engineering of the geldanamycin producing microorganism, Streptomyces hygroscopicus NRRL3602. These molecules retain the exquisite specificity of tanespimycin and alvespimycin for the ATP binding pocket of Hsp90, being the most avid binders reported to date, yet do not rely upon activation by NQO1 for maximal inhibitory activity. They are highly efficacious in the HCT-116 mouse tumor model. We report here that these non-benzoquinone ansamycins are exceptionally potent molecules in additional tumor models, including MV-4-11 and COLO205. The Flt-3 ITD mutation, found in the AML cell line MV-4-11, has been shown to confer sensitivity to tanespimycin in vitro. We demonstrated a similar in vitro response of MV-4-11 to the non-benzoquinone ansamycin KOS-2484 and went on to demonstrate that this in vitro sensitivity correlates with a significant in vivo response. Treatment of mouse MV-4-11 xenografts with KOS-2484 resulted in tumor regression. KOS-2484 was dosed at 7.5, 15, or 30 mg/kg via i.v. bolus on a daily schedule for 5 days with a 2-day holiday for a total of 10 doses, and each of these dose levels was associated with tumor shrinkage. While the response at 7.5 mg/kg was initially not as pronounced as those at the higher doses, after 10 doses, the responses had equalized. This is in accordance with the previously demonstrated long lifetime of KOS-2484 in tumor tissue (half-life ~30 hours), which allows tumor drug levels to build with successive administrations. All doses were well-tolerated with no observable body weight loss. Most remarkably, KOS-2484 showed almost complete regression of very large (1000 mm3) MV-4-11 xenografts after 10 doses. Thus, non-benzoquinone ansamycins produced by genetic engineering are among the most potent Hsp90 inhibitors reported to date and show significant efficacy in diverse mouse xenograft models.