tbuckley/cabot-search huggingface dataset:
Retrospective Analysis of Prognostic Factors for Waldenström Macroglobulinemia: A Multicenter Cooperative Study in Japan
Authors: Akio Saito, Atsushi Isoda, Akihiko Yokohama, Hiroshi Handa, Norifumi Tsukamoto, Yutaka Tsukune, Makoto Sasaki, Morio Matsumoto, Morio Sawamura, Shigeki Ito, Kohtaro Toyama, Michiaki Koike, Kayoko Murayama, Asaka Onodera, Keiichi Moriya, Hideto Tamura, Hirotaka Nakahashi, Sakae Tanosaki, Toru Sakura, Masamitsu Karasawa, Masanori Iwashina, Masaru Kojima, Naoya Nakamura, Hirokazu Murakami
Journal: Blood (2015)
Abstract 14326: Left Ventricular Unloading Preserves Energy Substrate Utilization and Protects the Functional Integrity of Mitochondrial Complex I in Preclinical Models of Ischemia With and Without Reperfusion
Authors: Lija Swain, Xiaoying Qiao, Lara A Reyelt, Aditya Chennojwala, Shreyas Bhave, Michael T Chin, Corinne Thomas, Shiva Annamalai, Paige Crowley, Navin K Kapur
Journal: Circulation (2019)

Mechanical unloading before reperfusion limits infarct size in preclinical models and is currently under clinical investigation in acute myocardial infarction (AMI). The impact of left ventricular ...
Biomimetic collagen biomaterial induces in situ lung regeneration by forming functional alveolar
Authors: Linjie Wang, Yannan Zhao, Feng Yang, Meng Feng, Yazhen Zhao, Xi Chen, Junwei Mi, Yuanjiang Yao, Dongwei Guan, Zhifeng Xiao, Bing Chen, Jianwu Dai
Journal: Biomaterials (2020)
Advanced Case of Achalasia That Appeared on 68Ga–Prostate-Specific Membrane Antigen PET/CT
Authors: Sara Shakeri, Fatemeh Farahmandfar, Golnaz Gholami, Nasim Norouzbeigi, Ramin Sadeghi
Journal: Clinical Nuclear Medicine (2020)

We report a known case of severe achalasia that appeared on Ga-prostate-specific membrane antigen (PSMA) PET/CT. The patient was a known case of high-grade transitional cell carcinoma and suspicious diagnosis of prostate cancer referred for Ga-PSMA PET/CT. Ga-PSMA PET/CT showed linear increased activity in the esophageal wall as well as a distended esophagus.
A global analysis of urban design types and road transport injury: an image processing study
Authors: Jason Thompson, Mark Stevenson, Jasper S Wijnands, Kerry A Nice, Gideon DPA Aschwanden, Jeremy Silver, Mark Nieuwenhuijsen, Peter Rayner, Robyn Schofield, Rohit Hariharan, Christopher N Morrison
Journal: The Lancet Planetary Health (2020)

Death and injury due to motor vehicle crashes is the world's fifth leading cause of mortality and morbidity. City and urban designs might play a role in mitigating the global burden of road transport injury to an extent that has not been captured by traditional safe system approaches. We aimed to determine the relationship between urban design and road trauma across the globe.Applying a combined convolutional neural network and graph-based approach, 1692 cities capturing one third of the world's population were classified into types based on urban design characteristics represented in sample maps. Associations between identified city types, characteristics contained within sample maps, and the burden of road transport injury as measured by disability adjusted life-years were estimated through univariate and multivariate analyses, controlling for the influence of economic activity.Between Mar 1, 2017, and Dec 24, 2018, nine global city types based on a final sample of 1632 cities were identified. Burden of road transport injury was an estimated two-times higher (risk ratio 2·05, 95% CI 1·84-2·27) for the poorest performing city type compared with the best performing city type, culminating in an estimated loss of 8·71 (8·08-9·25) million disability-adjusted life-years per year attributable to suboptimal urban design. City types that featured a greater proportion of railed public transport networks combined with dense road networks characterised by smaller blocks showed the lowest rates of road traffic injury.This study highlights the important role that city and urban design plays in mitigating road transport injury burden at a global scale. It is recommended that road and transport safety efforts promote urban design that features characteristics inherent in identified high-performance city types including higher density road infrastructure and high rates of public transit.See acknowledgments.
Abstract 16297: Educational and Learning Morbidity in Pediatric Heart Transplant Recipients: A Pediatric Heart Transplant Society Study
Authors: Micah S Brosbe, Lydia Wright, Elizabeth Pruitt, William J Dreyer, Sonya Kirmani, Margaret Knight, Stephanie Nakano, Steven J Kindel, Thomas D Ryan, James K Kirklin, Shriprasad R Deshpande
Journal: Circulation (2018)

Introduction: Educational development is an important component of quality of life for children with heart disease. While much research has shown cognitive and academic delays within the congenital...
Preclinical Activity of JNJ-7957, a Novel BCMA×CD3 Bispecific Antibody for the Treatment of Multiple Myeloma, Is Potentiated by Daratumumab
Authors: Kristine A. Frerichs, Marloes E.C. Broekmans, Jhon A. Marin Soto, Berris van Kessel, Martijn W. Heymans, Lisa C. Holthof, Christie P.M. Verkleij, Rengasamy Boominathan, Bhavesh Vaidya, Jocelyn Sendecki, Amy Axel, Francois Gaudet, Kodandaram Pillarisetti, Sonja Zweegman, Homer C. Adams, Tuna Mutis, Niels W.C.J. van de Donk
Journal: Clinical Cancer Research (2020)

Abstract Purpose: Multiple myeloma (MM) patients with disease refractory to all available drugs have a poor outcome, indicating the need for new agents with novel mechanisms of action. Experimental Design: We evaluated the anti-MM activity of the fully human BCMA×CD3 bispecific antibody JNJ-7957 in cell lines and bone marrow (BM) samples. The impact of several tumor- and host-related factors on sensitivity to JNJ-7957 therapy was also evaluated. Results: We show that JNJ-7957 has potent activity against 4 MM cell lines, against tumor cells in 48 of 49 BM samples obtained from MM patients, and in 5 of 6 BM samples obtained from primary plasma cell leukemia patients. JNJ-7957 activity was significantly enhanced in patients with prior daratumumab treatment, which was partially due to enhanced killing capacity of daratumumab-exposed effector cells. BCMA expression did not affect activity of JNJ-7957. High T-cell frequencies and high effector:target ratios were associated with improved JNJ-7957–mediated lysis of MM cells. The PD-1/PD-L1 axis had a modest negative impact on JNJ-7957 activity against tumor cells from daratumumab-naïve MM patients. Soluble BCMA impaired the ability of JNJ-7957 to kill MM cells, although higher concentrations were able to overcome this negative effect. Conclusions: JNJ-7957 effectively kills MM cells ex vivo, including those from heavily pretreated MM patients, whereby several components of the immunosuppressive BM microenvironment had only modest effects on its killing capacity. Our findings support the ongoing trial with JNJ-7957 as single agent and provide the preclinical rationale for evaluating JNJ-7957 in combination with daratumumab in MM.
Transgenic expression of human PRSS2 exacerbates pancreatitis in mice
Authors: Jianhua Wan, Ashley Haddock, Brandy Edenfield, Baoan Ji, Yan Bi
Journal: Gut (2020)

We read with great interest the study by Hegyi et al 1 which reported that a commonly occurring haplotype spanning the PRSS1-PRSS2 locus (encoding human cationic and anionic trypsinogens) is associated with chronic pancreatitis. While PRSS1 is the major focus in many studies,2 3 PRSS2 is also a major trypsinogen isoform synthesised in human pancreas. In normal human, the PRSS1/PRSS2 ratio is approximately 2:1.4 Chronic alcoholism increases the risk of pancreatitis. Strikingly, in these patients, total trypsinogen secretion was increased with selective upregulation of PRSS2, reversing the PRSS1/PRSS2 ratio.5 In vitro studies have shown human PRSS2 more sensitive to autocatalytic degradation and with lower autoactivation than PRSS1.6 In test tube assays under conditions of intracellular pathological trypsinogen activation, mixtures of PRSS1 and PRSS2 with increasing ratios of PRSS2 had markedly decreased rates of trypsinogen activation and yields of active trypsin.6 These observations led to a hypothesis that upregulation of PRSS2 may play a protective role against pancreatitis.6 …
IA34 The YAP/FOXM1 Axis Regulates EMT-Associated EGFR Tyrosine Kinase Inhibitor Resistance and Increased Expression of Spindle Assembly Checkpoint Components
Authors: M.B. Nilsson, H. Sun, J. Robichaux, L. Diao, Y. Xi, P. Tong, L. Sheng, M. Hofstad, M. Kawakami, X. Le, X. Liu, Y. Fang, A. Poteete, M. Vailati Negrao, H. Tran, E. Dmitrovsky, D. Peng, D. Gibbons, J. Wang, J.V. Heymach
Journal: Journal of Thoracic Oncology (2020)
99mTc-HDP Bone Scintigraphy, SPECT/CT, and 18F-FDG PET/CT Diagnosis Imaging of Incidental Pleural Mesothelioma in a Patient With Biochemical Recurrences of Prostate Cancer
Authors: Paula Fernández-Rodríguez, Juan José Martín-Marcuartu, Irene Acevedo Báñez, José Manuel Masero Carretero, José Manuel Jiménez-Hoyuela García
Journal: Clinical Nuclear Medicine (2019)

Abstract We present the case of a 69-year-old man with history of prostate carcinoma treated with prostatectomy and subsequently with external beam radiotherapy and hormone therapy because of biochemical recurrences. More than 10 years after the diagnosis, follow-up 99m Tc-HDP bone scans and SPECT/CT images demonstrated an incidental diagnosis of osteoblastic pleural plaques that quickly evolve to mesothelioma. PET/CT achieved the definitive diagnosis by guiding the biopsy to the highest and most accessible focus of glucidic hypermetabolism. Our case report raises the association between prostate cancer patients treated with external beam radiotherapy and the development of pleural mesothelioma despite having no history of exposure to asbestos.
Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer
Authors: Eric C. Cheung, Gina M. DeNicola, Colin Nixon, Karen Blyth, Christiaan F. Labuschagne, David A. Tuveson, Karen H. Vousden
Journal: Cancer Cell (2020)

The TIGAR protein has antioxidant activity that supports intestinal tissue repair and adenoma development. Using a pancreatic ductal adenocarcinoma (PDAC) model, we show that reactive oxygen species (ROS) regulation by TIGAR supports premalignant tumor initiation while restricting metastasis. Increased ROS in PDAC cells drives a phenotypic switch that increases migration, invasion, and metastatic capacity. This switch is dependent on increased activation of MAPK signaling and can be reverted by antioxidant treatment. In mouse and human, TIGAR expression is modulated during PDAC development, with higher TIGAR levels in premalignant lesions and lower TIGAR levels in metastasizing tumors. Our study indicates that temporal, dynamic control of ROS underpins full malignant progression and helps to rationalize conflicting reports of pro- and anti-tumor effects of antioxidant treatment.
Randomized, Multicenter, Phase II Trial of Gemcitabine and Cisplatin With or Without Veliparib in Patients With Pancreas Adenocarcinoma and a Germline <i>BRCA/PALB2</i> Mutation
Authors: Eileen M. O’Reilly, Jonathan W. Lee, Mark Zalupski, Marinela Capanu, Jennifer Park, Talia Golan, Esther Tahover, Maeve A. Lowery, Joanne F. Chou, Vaibhav Sahai, Robin Brenner, Hedy L. Kindler, Kenneth H. Yu, Alice Zervoudakis, Shreya Vemuri, Zsofia K. Stadler, Richard K. G. Do, Neesha Dhani, Alice P. Chen, David P. Kelsen
Journal: Journal of Clinical Oncology (2020)

Five percent to 9% of pancreatic ductal adenocarcinomas (PDACs) develop in patients with a germline
The Tumor Suppressor BAP1 Regulates the Hippo Pathway in Pancreatic Ductal Adenocarcinoma
Authors: Ho-June Lee, Trang Pham, Matthew T. Chang, Dwight Barnes, Allen G. Cai, Rajkumar Noubade, Klara Totpal, Xu Chen, Christopher Tran, Thijs Hagenbeek, Xiumin Wu, Jeff Eastham-Anderson, Janet Tao, Wyne Lee, Boris C. Bastian, Michele Carbone, Joshua D. Webster, Anwesha Dey
Journal: Cancer Research (2020)

The deubiquitinating enzyme BAP1 is mutated in a hereditary cancer syndrome with a high risk for mesothelioma and melanocytic tumors. Here, we show that pancreatic intraepithelial neoplasia driven by oncogenic mutant KrasG12D progressed to pancreatic adenocarcinoma in the absence of BAP1. The Hippo pathway was deregulated in BAP1-deficient pancreatic tumors, with the tumor suppressor LATS exhibiting enhanced ubiquitin-dependent proteasomal degradation. Therefore, BAP1 may limit tumor progression by stabilizing LATS and thereby promoting activity of the Hippo tumor suppressor pathway. SIGNIFICANCE: BAP1 is mutated in a broad spectrum of tumors. Pancreatic Bap1 deficiency causes acinar atrophy but combines with oncogenic Ras to produce pancreatic tumors. BAP1-deficient tumors exhibit deregulation of the Hippo pathway.
A14 Circulating Ensembles of Tumor-Associated Cells Are Ubiquitous in Lung Cancers
Authors: D.B. Akolkar, S. Limaye, D. Patil, P. Fulmali, P. Fulmali, S. Apurwa, S. Pawar, V. Datta, C. Sims, A. Srinivasan, R. Datar
Journal: Journal of Thoracic Oncology (2020)
Treatment with 24 hour istaroxime infusion in patients hospitalised for acute heart failure: a randomised, placebo‐controlled trial
Authors: Valentina Carubelli, Yuhui Zhang, Marco Metra, Carlo Lombardi, G. Michael Felker, Gerasimos Filippatos, Christopher M. O'Connor, John R. Teerlink, Phillip Simmons, Robert Segal, Gabriella Malfatto, Maria Teresa La Rovere, Dianfu Li, Xiumin Han, Zuyi Yuan, Yali Yao, Benjamin Li, Lit Fui Lau, Giuseppe Bianchi, Jian Zhang
Journal: European Journal of Heart Failure (2020)
Bacterial burden in the lower airways predicts disease progression in idiopathic pulmonary fibrosis and is independent of radiological disease extent
Authors: Rachele Invernizzi, Joseph Barnett, Bhavin Rawal, Arjun Nair, Poonam Ghai, Shaun Kingston, Felix Chua, Zhe Wu, Athol U. Wells, Elizabeth R. Renzoni, Andrew G. Nicholson, Alexandra Rice, Clare M. Lloyd, Adam J. Byrne, Toby M. Maher, Anand Devaraj, Philip L. Molyneaux
Journal: European Respiratory Journal (2020)

Increasing bacterial burden in the lower airways of patients with idiopathic pulmonary fibrosis confers an increased risk of disease progression and mortality. However, it remains unclear whether this increased bacterial burden directly influences progression of fibrosis or simply reflects the magnitude of the underlying disease extent or severity. We prospectively recruited 193 patients who underwent bronchoscopy and received a multidisciplinary diagnosis of idiopathic pulmonary fibrosis. Quantification of the total bacterial burden in bronchoalveolar lavage fluid was performed by 16S rRNA gene qPCR. Imaging was independently evaluated by two readers assigning quantitative scores for extent, severity and topography of radiographic changes and relationship of these features with bacterial burden was assessed. Increased bacterial burden significantly associated with disease progression (HR 2.1; 95% CI 1.287–3.474; p=0.0028). Multivariate stepwise regression demonstrated no relationship between bacterial burden and radiological features or extent of disease. When specifically considering patients with definite or probable usual interstitial pneumonia there was no difference in bacterial burden between these two groups. Despite a postulated association between pleuroparenchymal fibroelastosis and clinical infection, there was no relationship between either the presence or extent of pleuroparenchymal fibroelastosis and bacterial burden. We demonstrate that bacterial burden in the lower airways is not simply secondary to the extent of the underlying architectural destruction of the lung parenchyma seen in idiopathic pulmonary fibrosis. The independent nature of this association supports a relationship with the underlying pathogenic mechanisms and highlights the urgent need for functional studies.
Re: Samuelson et al.: Prospective, randomized, controlled pivotal trial of an ab interno implanted trabecular micro-bypass in primary open-angle glaucoma and cataract: two-year results (Ophthalmology. 2019;126:811-821)
Authors: Karina Carvalho Melo Araújo, Elson Cabral Velanes Neto, Ana Luiza Bassoli Scoralick, Fabio Nishimura Kanadani, Tiago Santos Prata
Journal: Ophthalmology (2020)
B33 Short-Term Exposure to REV-5901 Decreases the Viability of Chemotherapy-Resistant Adherent Lung Cancer Cells and Floating Tumorspheres
Authors: J.S. Yakisich, R. Venkatadri, B. Brinceanu, C. Woodard, V. Kaushik, N. Azad, A.K.V. Iyer
Journal: Journal of Thoracic Oncology (2020)
Nodular Fat-Sparing Hepatic Parenchyma as 11C-Choline–Avid Finding on PET/CT
Authors: Ba Duong Nguyen, Matthew T. Heller, Michael C. Roarke
Journal: Clinical Nuclear Medicine (2019)

Abstract Focal nodular fat sparing of the liver may show, on PET/CT imaging, prominent tracer uptake over a background of less metabolic features of steatosis. This finding, already reported with 18 F-FDG, may mimic primary or secondary neoplasms of the liver. The authors present an additional case of nodular fat-sparing hepatic parenchyma exhibiting 11 C-choline avidity during PET/CT assessment for biochemical recurrence of prostate cancer.
Letter to the Editor: Coinfection of Human Immunodeficiency Virus With Hepatitis C Virus: A Change of Paradigm
Authors: Patrícia dos Santos Marcon, Angelo Zambam de Mattos, Angelo Alves de Mattos
Journal: Hepatology (2020)

Potential conflicts of interest: Nothing to report. To the Editor: We have read with interest the paper by Salmon‐Ceron et al.1 Although the results show an increase in overall mortality in human immunodeficiency virus (HIV)/hepatitis C virus (HCV)–coinfected patients, the similar risk of developing hepatocellular carcinoma (HCC) compared to HCV‐monoinfected patients, somewhat unexpected, was not surprising for us. In the past we have shown no difference in fibrosis progression rate between HCV‐monoinfected and HIV/HCV‐coinfected patients.2 More recently, we reviewed data from 399 coinfected and 405 monoinfected patients in southern Brazil, demonstrating the absence of correlation between HIV coinfection and the increase in HCC incidence.3 Unlike the study by Salmon‐Ceron et al.,1 our population also included patients without cirrhosis, and coinfected patients were more frequently non‐Caucasians (P = 0.006) and less frequently infected by HCV genotype 3 (P = 0.005). Coinfected patients had an HCC incidence rate of 0.25 cases per 100 patient‐years, while monoinfected patients had an incidence rate of 0.72 (P = 0.003). Nevertheless, coinfected patients were younger and probably had a shorter exposure to liver injury factors, and when the incidence rate of HCC was adjusted for age, there was no longer a significant difference between coinfected and monoinfected patients (P = 0.529). When analyzing only patients with cirrhosis, HCC incidence density was 1.54 cases per 100 patient‐years (95% confidence interval [CI], 0.74‐2.83) in coinfected patients and 2.31 (95% CI, 1.51‐3.38) in monoinfected ones (P = 0.202).3 Another study from South America had similar results, with an incidence density of 1.54 cases per 100 patient‐years in coinfected patients and 3.03 cases per 100 patient‐years in monoinfected ones (P = 0.3225).4 In conclusion, we believe that it is noteworthy to highlight that in populations with different ethnicity and infected with different genotypes of HCV, coinfection with HIV does not seem to play an important role in the development of HCC. Time of exposure to liver injury factors, such as HCV, probably is a more important factor in liver carcinogenesis.
RUNX1による血小板ミオシン軽鎖(MYL9)の制御:RUNX1ハプロ欠損における血小板減少症と血小板機能異常症への影響
Authors: Jalagadugula Gauthami, Mao Guangfen, Kaur Gurpreet, E Goldfinger Lawrence, N Dhanasekaran Danny, Rao A. Konetl
Journal: Blood (2010)
RUNX1による血小板ミオシン軽鎖(MYL9)の制御:RUNX1ハプロ欠損における血小板減少症と血小板機能異常症への影響 | 文献情報 | J-GLOBAL 科学技術総合リンクセンター
Authors: Jalagadugula Gauthami, Mao Guangfen, Kaur Gurpreet, E Goldfinger Lawrence, N Dhanasekaran Danny, Rao A. Konetl
Journal: Blood (2010)
5-year mental health and eating pattern outcomes following bariatric surgery in adolescents: a prospective cohort study
Authors: Kajsa Järvholm, Gustaf Bruze, Markku Peltonen, Claude Marcus, Carl-Erik Flodmark, Pia Henfridsson, Andrew J Beamish, Eva Gronowitz, Jovanna Dahlgren, Jan Karlsson, Torsten Olbers
Journal: The Lancet Child & Adolescent Health (2020)
Payment for Services Rendered — Updating Medicare’s Valuation of Procedures
Authors: Andrew W. Mulcahy, Katie Merrell, Ateev Mehrotra
Journal: New England Journal of Medicine (2020)

For most surgical procedures, Medicare and many other insurers give physicians a single bundled payment that covers both the procedure itself and related postoperative care. But reports suggest that the bulk of expected postoperative visits aren't taking place.
Deep phenotyping detects a pathological CD4+ T-cell complosome signature in systemic sclerosis
Authors: Giuseppina Arbore, Voon H. Ong, Benedetta Costantini, Christopher P. Denton, David Abraham, Leo Placais, Kevin Blighe, Lynne Mitchell, Richard Ellis, Susanne Heck, Paola Nocerino, Trent M. Woodruff, Shahram Kordasti, Claudia Kemper, Dennis E. Hourcade
Journal: Cellular and Molecular Immunology (2020)
18F-FDG PET/CT Imaging Findings of Leprosy
Authors: Dan Shao, Yue-Ting Deng, Fu-Qiang Shao, Jia-Wei Liang, Shu-Xia Wang
Journal: Clinical Nuclear Medicine (2020)

Leprosy is a chronic infectious disease caused by Mycobacterium leprae infection in susceptible individuals. Without proper clinical diagnosis and treatment, leprosy can have a poor prognosis; however, diagnosing leprosy is challenging. We present a case of leprosy with extensive skin infiltration and involvement of the turbinate mucosa and multiple lymph nodes with increased FDG uptake on PET/CT, mimicking malignancy.
2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk
Authors: David C. Goff, Donald M. Lloyd-Jones, Glen Bennett, Sean Coady, Ralph B. D’Agostino, Raymond Gibbons, Philip Greenland, Daniel T. Lackland, Daniel Levy, Christopher J. O’Donnell, Jennifer G. Robinson, J. Sanford Schwartz, Susan T. Shero, Sidney C. Smith, Paul Sorlie, Neil J. Stone, Peter W. F. Wilson
Journal: Circulation (2013)
A37 N-803 Plus Nivolumab for Advanced or Metastatic Non-Small Cell Lung Cancer: Update on Phase II Experience of Combination PD1 Blockade with an IL-15 Superagonist
Authors: J. Wrangle, V. Velcheti, M. Patel, M. Sweiderska-syn, L. Macpherson, C. Coggins, C. Kreig, W. Redmond, A. Rock, J. Lee, M. Rubinstein
Journal: Journal of Thoracic Oncology (2020)
Cost Effectiveness of Pemetrexed/Cisplatin (PEM/CIS) in the Treatment of Advanced, Non-Squamous, Non-Small Cell Lung Cancer (NSQNSCLC) Patients
Authors: K.B. Winfree, M. Shah, P. Peterson, S. Gruschkus, M. Eaddy, M. Green
Journal: Annals of Oncology (2012)
Temsirolimus Is Active in Refractory Squamous Cell Carcinoma of the Head and Neck (SCCHN) Failing Platinum-Based Chemotherapy and Cetuximab: Efficacy and Toxicity Data from the Phase II Temhead Study
Authors: V. Grünwald, U. Keilholz, A. Boehm, O. Guntinas-Lichius, B. Hennemann, H.J. Schmoll, P. Ivanyi, A. Zörner, A. Zapf, T.C. Gauler
Journal: Annals of Oncology (2012)