tbuckley/cabot-search huggingface dataset:
Safety and Tolerability of Daratumumab in Patients with Relapsed Light Chain (AL) Amyloidosis: Preliminary Results of a Phase II Study
Authors: Vaishali Sanchorawala, Shayna Sarosiek, John Mark Sloan, Dina Brauneis, Mary Ellen Migre, Meredith Mistark, Stephanie Santos, Salli Fennessey, Anthony C Shelton
Journal: Blood (2017)
RCGP drops course on trans health in response to members’ concerns
Authors: Harriet Pike
Journal: BMJ (2019)

An online course for GPs on gender variance has been withdrawn by the Royal College of General Practitioners after members raised concerns about its content.

The course, provided by the Gender Identity Research and Education Society (Gires), had been hosted on the RCGP website since 2015 but was withdrawn because GPs were worried that it might create “unrealistic expectations for patients regarding the role of the GP in initiating treatment” for gender reassignment.

The feedback prompted the RCGP to review and amend the course, but its changes were not acceptable to Gires, and the course was subsequently dropped from the RCGP website.

Jonathan Leach, RCGP honorary secretary, …
Donor T Cells Require Notch Signals but Not Alloantigen Presentation from Specialized Secondary Lymphoid Organ Fibroblasts to Drive Graft-Versus-Host Disease
Authors: Eric Perkey, Léolène Carrington, Jooho Chung, David Granadier, Alexander Dils, Ann Friedman, Anastasia Tikhonova, Bruce R. Blazar, Ute Koch, Nathalie Labrecque, Freddy Radtke, Chris Siebel, Iannis Aifantis, Ivan Maillard
Journal: Blood (2018)
The Pediatric Asthma Risk Score (PARS) Predicts Atopic and Non-atopic Asthma Better than the Asthma Predictive Index
Authors: Eric M. Schauberger, Jocelyn Biagini Myers, Hua He, Lisa J. Martin, John Kroner, Patrick H. Ryan, David I. Bernstein, James E. Lockey, Grace K. LeMasters, Syed H. Arshad, Ramesh J. Kurukulaaratchy, Gurjit K. Khurana Hershey
Journal: Journal of Allergy and Clinical Immunology (2019)
Immature Platelet Fraction Based Diagnostic Predictive Model for Immune Thrombocytopenic Purpura
Authors: Min Ji Jeon, Hojoon Choi, Eun Sang Yu, Ka-Won Kang, Byung-Hyun Lee, Dae Sik Kim, Yong Park, Se Ryeon Lee, Hwa Jung Sung, Chul Won Choi, Byung Soo Kim
Journal: Blood (2018)
Identity fusion “in the wild”: Moving toward or away from a general theory of identity fusion?
Authors: William B. Swann, Jolanda Jetten
Journal: Behavioral and Brain Sciences (2018)

Abstract Whitehouse's focus on two causes of identity fusion (evolution and shared experiences/biology) deepens understanding of these specific topics. While we applaud his analysis, in his efforts to elaborate these two causes, he has – perhaps unavoidably – produced a narrower conceptualization of identity fusion. This is unfortunate because it undermines his stated goal of developing a more general, encompassing theory.
Abstract PR09: Cancer-specific retargeting of BAF complexes by a prion-like domain
Authors: Gaylor Boulay, Gabriel J. Sandoval, Nicolo Riggi, Sowmya Iyer, Rémi Buisson, Beverly Naigles, Mary E. Awad, Shruthi Rengarajan, Angela Volorio, Matthew J. McBride, Liliane C. Broye, Lee Zou, Ivan Stamenkovic, Cigall Kadoch, Miguel N. Rivera
Journal: Cancer Research (2018)

Abstract Alterations in transcriptional regulators can orchestrate oncogenic gene expression programs in cancer. Here we show that the BAF chromatin-remodeling complex, which is mutated in over 20% of human tumors, interacts with EWSR1, a member of a family of proteins with prion-like domains (PrLD) that are frequent partners in oncogenic fusions with transcription factors. In Ewing sarcoma, we find that the BAF complex is recruited by the EWS-FLI1 fusion protein to tumor-specific enhancers and contributes to target gene activation. This process is a neomorphic property of EWS-FLI1 compared to wild-type FLI1 and depends on tyrosine residues that are necessary for phase transitions of the EWSR1 prion-like domain. Furthermore, fusion of short fragments of EWSR1 to FLI1 is sufficient to recapitulate BAF complex retargeting and EWS-FLI1 activities. Our studies thus demonstrate that the physical properties of prion-like domains can retarget critical chromatin regulatory complexes to establish and maintain oncogenic gene expression programs. Citation Format: Gaylor Boulay, Gabriel J. Sandoval, Nicolo Riggi, Sowmya Iyer, Rémi Buisson, Beverly Naigles, Mary E. Awad, Shruthi Rengarajan, Angela Volorio, Matthew J. McBride, Liliane C. Broye, Lee Zou, Ivan Stamenkovic, Cigall Kadoch, Miguel N. Rivera. Cancer-specific retargeting of BAF complexes by a prion-like domain [abstract]. In: Proceedings of the AACR Special Conference: Pediatric Cancer Research: From Basic Science to the Clinic; 2017 Dec 3-6; Atlanta, Georgia. Philadelphia (PA): AACR; Cancer Res 2018;78(19 Suppl):Abstract nr PR09.
Women's Health Policy in the United States
Authors: Hilary Daniel, Shari M. Erickson, Sue S. Bornstein
Journal: Annals of Internal Medicine (2019)

Letters19 February 2019Women's Health Policy in the United StatesHilary Daniel, BS, Shari M. Erickson, MPH, and Sue S. Bornstein, MDHilary Daniel, BSAmerican College of Physicians, Washington, DC (H.D., S.M.E.), Shari M. Erickson, MPHAmerican College of Physicians, Washington, DC (H.D., S.M.E.), and Sue S. Bornstein, MDTexas Medical Home Initiative, Dallas, Texas (S.S.B.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L18-0628 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:The topic of reproductive health care services is a complex, personal, and often polarizing issue, and ACP respects the diverse views of its members. However, we disagree that ACP is using its reputation to influence a political debate or that the scientific reasoning in this position paper is misguided. In this paper, ACP advocates for a woman's right to make her own health care decisions in consultation with her physicians and within her constitutional right to privacy (1). Women should have access to evidence-based health care services and medically accurate information, including that about reproductive health care services, ...References1. Roe v. Wade, 410 U.S. 113 (1973). Google Scholar2. Brief of Amici Curiae American College of Obstetricians and Gynecologists and the American Medical Association in support of plaintiffs-appellees-cross-appellants and in support of affirmance. No. 14-50928. 2014. Accessed at www.reproductiverights.org/sites/crr.civicactions.net/files/documents/2014-12-01%20-XX-%20Amicus%20Brief–ACOG%20and%20AMA.PDF on 9 October 2018. Google Scholar3. National Academies of Sciences, Engineering, and Medicine. The Safety and Quality of Abortion Care in the United States. Washington, DC: National Academies Pr; 2018. doi:10.17226/24950 CrossrefGoogle Scholar Author, Article, and Disclosure InformationAffiliations: American College of Physicians, Washington, DC (H.D., S.M.E.)Texas Medical Home Initiative, Dallas, Texas (S.S.B.)Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M17-3344. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoWomen's Health Policy in the United States: An American College of Physicians Position Paper Hilary Daniel , Shari M. Erickson , Sue S. Bornstein , and Women's Health Policy in the United States David Carl Houghton Women's Health Policy in the United States Paul M. Shaniuk Metrics Cited byBeyond Contraception: Pharmacist Roles to Support Maternal Health 19 February 2019Volume 170, Issue 4Page: 281-282KeywordsHealth careHealth care qualityHealth information technologyMedical servicesObstetrics and gynecologyPregnancyReasoningSafetyUterusVagina ePublished: 19 February 2019 Issue Published: 19 February 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Are quantitative measures of visceral adiposity obtained after neoadjuvant chemoradiation associated with postoperative morbidity in patients with locally advanced rectal cancer?
Authors: Leah E. Hendrick, Veronica Lippuner, Tyler Speaks, Travis S Scharr, Andrew M Fleming, Whitney M Guerrero, Evan Scott Glazer, Andrew W Dyer, David Shibata
Journal: Journal of Clinical Oncology (2019)

514 Background: Body mass index (BMI) is an inconsistent predictor of surgical morbidity in cancer patients. Increased visceral obesity measured before neoadjuvant chemoradiation (NCR) has been associated with post-operative morbidity in rectal cancer (RC). We sought to evaluate whether visceral obesity/BMI measured immediately after NCR correlates with postoperative complications in a heterogenous, largely underserved cohort of RC patients. Methods: 116 patients (64% white, 34% black, 2% other) underwent proctectomy for stage II/III RC after NCR. Automated CT segmentation software was used to determine body fat distribution at the L4/L5 level. Patients were classified as obese by BMI (≥ 30 kg/m 2 ) and post-NCR CT measures of adiposity including visceral fat area (VFA; &gt; 100cm 2 ), visceral to subcutaneous fat area ratio (V/S; &gt; 0.4), and perinephric fat thickness (PNF; &gt; median) were obtained. Complications were classified (Clavien-Dindo) into low (1-2) or high (3-4) grade. Associations between measures of adiposity, short-term surgical outcomes and clinicopathologic factors were evaluated with one-way ANOVA, Chi-square, and Fischer’s exact test as appropriate for overall, white, and non-white cohorts. Results: Obese patients by adiposity measures (but not BMI) were more likely to be male by V/S (91.4% vs. 54.3%, p ≤ 0.001) and PNF (62.9% vs. 26.1%, p ≤ 0.001), Caucasian by VFA (mean 135.2 cm 2 vs. 93.8 cm 2 , p = 0.002), and have preexisting metabolic comorbidities by VFA and PNF ( p &lt; 0.01). V/S was associated with the presence of key metabolic comorbidities in both white and non-white groups ( p &lt; 0.05). Obesity by V/S but not BMI was associated with development of postoperative complications in the non-white group (65.5% vs. 30.8%, p = 0.049), but not in the overall or white cohorts. Conclusions: V/S as measured after NCR is associated with presence of key metabolic comorbidities in the entire cohort but with postoperative complications only in non-white patients. Given these observations, further evaluation of the impact of socioeconomic factors and change in adiposity between pre- and post-NCR time periods is warranted.
Trends in BRCA Test Utilization in an Integrated Health System, 2005–2015
Authors: Sarah Knerr, Erin J A Bowles, Kathleen A Leppig, Diana S M Buist, Hongyuan Gao, Karen J Wernli
Journal: JNCI Journal of the National Cancer Institute (2019)

Abstract Background Genetic testing to determine BRCA status has been available for over two decades, but there are few population-based studies of test diffusion. We report 10-year trends in BRCAtesting in an integrated health-care system with long-standing access to genetic services. Methods A cohort of women aged 18 years and older was created to ascertain BRCA testing (n = 295 087). Annual testing rates between 2005 and 2015 were calculated in all women with and without incident (ie, newly diagnosed) breast and ovarian cancers and in clinically eligible subgroups by family cancer history, personal cancer history, and age at diagnosis. Secular trends were assessed using Poisson regression. Women tested early (2005–2008), midway (2009–2012), and late (2013–2015) in the study period were compared in cross-sectional analyses. Results Between 2005 and 2015, annual testing rates increased from 0.6/1000 person-years (pys) (95% confidence interval [CI] = 0.4 to 0.7/1000 pys) to 0.8/1000 pys (95% CI = 0.6 to 1.0/1000 pys) in women without incident breast or ovarian cancers. Rates decreased from 71.5/1000 pys (95% CI = 42.4 to 120.8/1000 pys) to 44.4/1000 pys (95% CI = 35.5 to 55.6/1000 pys) in women with incident diagnoses, despite improvements in provision of timely BRCA testing during this time frame. We found no evidence of secular trends in clinically eligible subgroups including women with family history indicating increased hereditary cancer risk, but no personal cancer history. At the end of the study period, 97.0% (95% CI = 96.6% to 97.3%) of these women remained untested. Conclusion Many eligible women did not receive BRCA testing despite having insurance coverage and access to specialty genetic services, underscoring challenges to primary and secondary hereditary cancer prevention.
Accidental Exposures to Peanut and Other Food Allergens: Results from a Phase 3, Randomized, Double-Blind, Placebo-Controlled Trial (PALISADE)
Authors: Jonathan O'B. Hourihane, Jay A. Lieberman, J. Andrew Bird, Tara F. Carr, Noelle M. Griffin, Kari R. Brown, Rezi Zawadzki, Allyah Abbas, John Matthews, Stacie M. Jones
Journal: Journal of Allergy and Clinical Immunology (2019)
Abstract 10813: Dipeptidyl Peptidase-4 Inhibitors Attenuate Endothelial Function as Evaluated by Flow-mediated Vasodilatation in Type 2 Diabetic Patients
Authors: Makoto Ayaori, Naotsugu Iwakami, Harumi Uto-Kondo, Makoto Sasaki, Tomohiro Komatsu, Maki Iizuka, Shunichi Takiguchi, Emi Yakushiji, Kazuhiro Nakaya, Makiko Yogo, Masatsune Ogura, Hiroki Sato, Bonpei Takase, Katsunori Ikewaki
Journal: Circulation (2012)

Endothelial dysfunction is an independent predictor for cardiovascular events in patients with type 2 diabetes (T2DM). Glucagon like peptide-1 (GLP-1) reportedly exerts vasodilatory actions and inh...
Abstract 20613: Inadequate Loop Diuretic Dosing in Acute Heart Failure: A Missed Opportunity
Authors: Chad E Darling, Gary Zimmer, Yelena Malyuta, David D McManus
Journal: Circulation (2016)

Introduction: Loop diuretics are a mainstay of acute decompensated heart failure (ADHF) treatment in the Emergency Department (ED). Guidelines regarding the use of diuretics are variable, but most ...
Upright Integrated Relaxation Pressure Facilitates Characterization of Esophagogastric Junction Outflow Obstruction
Authors: Joseph R. Triggs, Dustin A. Carlson, Claire Beveridge, Anand Jain, Michael Y. Tye, Peter J. Kahrilas, John E. Pandolfino
Journal: Clinical Gastroenterology and Hepatology (2019)
Effects of Lactobacillus pentosus for the treatment of childhood atopic dermatitis: A randomized, double-blind, placebo-controlled clinical study
Authors: Young Yoo, So Hyun Ahn, Dae Jin Song, Wonsuck Yoon, Hyo Sun Lee, Wang Kuk Son, Dasarang Kim, So-Young Lee, Chae Bong Kim
Journal: Journal of Allergy and Clinical Immunology (2019)
Additional Prognostic Value of 2D Right Ventricular Speckle-Tracking Strain for Prediction of Survival in Heart Failure and Reduced Ejection Fraction
Authors: Laura Houard, Marie-Bénédicte Benaets, Christophe de Meester de Ravenstein, Michel F Rousseau, Sylvie A Ahn, Mihaela-Silvia Amzulescu, Clotilde Roy, Alisson Slimani, David Vancraeynest, Agnès Pasquet, Jean-Louis J Vanoverschelde, Anne-Catherine Pouleur, Bernhard L Gerber
Journal: JACC. Cardiovascular imaging (2019)
Abstract 24010: Muscle-specific A-Kinase Anchoring Protein Polymorphisms Pre-dispose Humans to Cardiovascular Diseases by Affecting cyclic AMP/PKA Signaling
Authors: Santosh Suryavanshi, Shweta Jadhav, Kody Anderson, Panagiotis Katsonis, Olivier Lichtarge, Bradley K McConnell
Journal: Circulation (2017)

In-depth understanding of key cardiac signaling pathways is crucial in finding new targets for cardiovascular diseases (CVDs), the no. 1 cause of deaths globally. One of such pathways is cAMP-dependent PKA signaling which is modulated by scaffold proteins, A-kinase anchoring proteins (AKAPs). Muscle-specific AKAP (mAKAP) regulates expression of hypertrophic factors partly by controlling cardiac cAMP levels. Furthermore, published literature revealed a strong correlation between single nucleotide polymorphisms (SNPs) in proteins and risk of developing CVDs by varying cAMP/PKA signaling. This aspect of AKAPs has been largely unexplored. Hence, we hypothesized that mAKAP SNPs alter cAMP/PKA signaling making individuals susceptible to CVDs. We analyzed selected mAKAP SNPs found often in human patients with CVDs through multiple online tools that predict functional effects of SNPs to finalize two SNPs, Ser(S)1653Arg(R) in PDE4D3 binding domain and Glu(E)2124Gly(G) in 3’-PKA binding domain of mAKAP. After making both mAKAP mutant plasmids from WT using site-directed mutagenesis, we studied them in HEK 293T cells. Four separate samples were used for each experiment. In immunoprecipitation studies, S1653R mutant showed increased binding to PDE4D3 at baseline but significantly reduced binding after stimulation with 1 μM isoproterenol as compared to WT. Similarly, E2124G mutant exhibited significantly lower PKA binding at baseline and higher binding after stimulation. cAMP levels and PKA activity were significantly lower at baseline but higher after stimulation in S1653R mutant cells. Also, E2124G expressed cells showed no significant change in cAMP levels when compared to WT but PKA activity was significantly lower at baseline followed by abrupt increase after stimulation. PDE activity assay was in congruent with cAMP changes in S1653R mutant cells. Fluorometric assay showed higher intracellular calcium in E2124G mutant cells after stimulation. Lastly, immunoblotting data showed altered phosphorylation of hypertrophic markers in both mutants. To conclude, human mAKAP SNPs may pre-dispose humans to the risk of developing CVDs by affecting cAMP/PKA signaling and thus confirming the clinical significance of PKA-mAKAP-PDE4D3 interaction.
Women's Health Policy in the United States
Authors: David Carl Houghton
Journal: Annals of Internal Medicine (2019)

Letters19 February 2019Women's Health Policy in the United StatesDavid Carl Houghton, MDDavid Carl Houghton, MDIntermountain Healthcare, Ogden, Utah (D.C.H.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L18-0627 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I agree wholeheartedly with Shaniuk's comment about ACP's (1) regrettable decision to use its scientific reputation to sway a political debate. That a fetus is an independent human organism is incontrovertible according to embryologic science. “Continuing a pregnancy” is a phrase that arbitrarily places a mother's health concerns above the basic acknowledgment of this scientific fact.There is no scientific difference between a mother who chooses to stop feeding her newborn and a mother who chooses to discontinue a pregnancy. To be sure, there are valid ethical dilemmas involved. However, the position paper does not address them ...Reference1. Daniel H, Erickson SM, Bornstein SS; Health and Public Policy Committee of the American College of Physicians. Women's health policy in the United States: an American College of Physicians position paper. Ann Intern Med. 2018;168:874-5. [PMID: 29809243]. doi:10.7326/M17-3344 LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Intermountain Healthcare, Ogden, Utah (D.C.H.)Disclosures: The author has disclosed no conflicts of interest. The form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L18-0627. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoWomen's Health Policy in the United States: An American College of Physicians Position Paper Hilary Daniel , Shari M. Erickson , Sue S. Bornstein , and Women's Health Policy in the United States Hilary Daniel , Shari M. Erickson , and Sue S. Bornstein Women's Health Policy in the United States Paul M. Shaniuk Metrics 19 February 2019Volume 170, Issue 4Page: 281KeywordsConflicts of interestCrimeDisclosureEuthanasiaFetusesMedical lawObstetrics and gynecologyPregnancy ePublished: 19 February 2019 Issue Published: 19 February 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Genomic Abnormalities Among African Individuals with Monoclonal Gammopathies Using Calculated Ancestry
Authors: Linda B Baughn, Dirk Larson, Mei-Yin Polley, Kathryn E. Pearce, Eran Elhaik, Michael L. Baird, Colin Colby, Joanne Benson, Zhou Li, Yan Asmann, Terry Therneau, James R. Cerhan, Celine M. Vachon, A Keith Stewart, P. Leif Bergsagel, Angela Dispenzieri, Shaji K. Kumar, S. Vincent Rajkumar
Journal: Blood (2018)
Delivering the Thinking Healthy Programme for perinatal depression through peers: an individually randomised controlled trial in India
Authors: Daniela C Fuhr, Benedict Weobong, Anisha Lazarus, Fiona Vanobberghen, Helen A Weiss, Daisy Radha Singla, Hanani Tabana, Ejma Afonso, Aveena De Sa, Ethel D'Souza, Akankasha Joshi, Priya Korgaonkar, Revathi Krishna, LeShawndra N Price, Atif Rahman, Vikram Patel
Journal: The Lancet Psychiatry (2019)
The “Guardian of the Genome”—An Old Key to Unlock the ERCC1 Issue
Authors: Luc Friboulet, Jean-Charles Soria, Ken André Olaussen
Journal: Clinical Cancer Research (2019)

Excision Repair Cross-Complementation Group 1 (ERCC1) participates in the repair of DNA intrastrand adducts (ISA) and interstrand cross-links, but its role as a predictive biomarker has never been fully validated. It has now been revealed that p53 mutation status should be considered concomitantly with ERCC1 to predict cisplatin efficacy.See related article by Heyza et al., p. 2523.
Psychiatrists cancel cannabis debate after no one would argue for criminalising users
Authors: Richard Hurley
Journal: BMJ (2019)

A debate on whether criminalising people who use cannabis protects against mental ill health did not take place because no one agreed to argue that current UK law protects the health of people who take the drug.

Instead, only David Nutt, professor of neuropsychopharmacology at Imperial College London, spoke on 23 January at the Royal College of Psychiatrists in London.

The motion to have been debated was: “Decriminalising cannabis use will lead to higher rates of mental illness.”

Wendy Burn, the college’s president, told The BMJ , “The concern, for psychiatrists, is the link between cannabis and mental illness. Later this year, the college will be thoroughly reviewing the evidence on the effects of cannabis use on mental …