tbuckley/cabot-search huggingface dataset:
T-Cell Receptor Vß CDR3 Oligoclonality Frequently Occurs in Childhood Refractory Cytopenia and Severe Aplastic Anemia.
Authors: Andrica C.H. de Vries, Anton W. Langerak, Brenda Verhaaf, Charlotte Marie Niemeyer, Jan Stary, Kjeld Schmiegelow, Elisabeth van Wering, Auke Beishuizen, Rob Pieters, M.M. Van Den Heuvel
Journal: Blood (2007)
Structural and Functional Studies to Define the Molecular Basis by Which Platelet Factor 4 (PF4) Increases Survival of Mice in Lipopolysaccharide (LPS)-Induced Endotoxicity
Authors: M. Anna Kowalska, Karine Amirikian, Laurent O. Mosnier, Hartmut Weiler, Sriram Krishnaswamy, Mortimer Poncz
Journal: Blood (2008)
T cell–derived interferon-γ programs stem cell death in immune-mediated intestinal damage
Authors: S. Takashima, M. L. Martin, S. A. Jansen, Y. Fu, J. Bos, D. Chandra, M. H. O’Connor, A. M. Mertelsmann, P. Vinci, J. Kuttiyara, S. M. Devlin, S. Middendorp, M. Calafiore, A. Egorova, M. Kleppe, Y. Lo, N. F. Shroyer, E. H. Cheng, R. L. Levine, C. Liu, R. Kolesnick, C. A. Lindemans, A. M. Hanash
Journal: Science Immunology (2019)

T cell–derived interferon-γ can directly target intestinal stem cells to induce their apoptosis in a JAK/STAT-dependent manner (see the related Focus by Kretzschmar and Clevers ).
Abstract 14435: Can Syntax Scores Predict Major Cardiac Events in People Living With Human Immunodeficiency Virus Presenting With Acute Coronary Syndrome?
Authors: Raphael Robert, Yves Cottin, Valerie Potard, Murielle Mary-Krause, Sylvie Lang, Emmanuel Teiger, Nadjib Hammoudi, Marion Chauvet-Droit, Stephane Ederhy, Laurie Dufour-Soulat, Yann Ancedy, Saroumadi Adavane-Scheuble, Pascal Nhan, Philippe G Steg, Christian J Funck-Brentano, Pierre Marie Girard, Dominique Costagliola, Ariel A Cohen, Franck Boccara
Journal: Circulation (2019)

Introduction: Patients living with human immunodeficiency virus (PLHIV) who undergo percutaneous coronary intervention (PCI) have a substantial risk of reccurent ischemic events after ACS. Hypothes...
Preliminary Results of a Phase I/II Trial of BBR-2778 (Pixantrone) in Combination with Fludarabine, Dexamethasone, and Rituximab (FPD-R) in the Treatment of Patients with Relapsed/Refractory Indolent Non-Hodgkin’s Lymphoma (NHL).
Authors: Luis Fayad, James Liebmann, Manuel Modiano, Gary I. Cohen, Barbara Pro, Jorge Romaguera, Cristina Davite, Margarita Lymboura, Silvia Comis, Bernard L. Laffranchi
Journal: Blood (2004)
По материалам панели дискуссии «Ключевые вопросы диагностики и лечения хронических воспалительных заболеваний толстой кишки »в рамках научно-практической конференции «VII научная сессия ГУ« Институт гастроэнтерологии НАМН Украины ». Новейшие технологии в
Authors: Yu.M. Stepanov, M.V. Stoikevych
Journal: GASTROENTEROLOGY (2019)

No abstract
Comparative Outcome of Reduced Intensity and Myeloablative Preparative Regimen in HLA Identical Sibling Allogeneic Hematopoietic Stem Cell Transplantation for Patients Older Than 50 Years of Age with Acute Myeloblastic Leukaemia: A Retrospective Survey from the Acute Leukemia Working Party (ALWP) of the European Group for Blood and Marrow Transplantation (EBMT).
Authors: Malek Aoudjhane, Norbert-Claude Gorin, Myriam Labopin, Avichai Shimoni, Dietger Niederwieser, Arnon Nagler, Vanderson Rocha
Journal: Blood (2005)
Monoclonal antibody-based molecular imaging strategies and theranostic opportunities
Authors: Niels Dammes, Dan Peer
Journal: Theranostics (2019)

Molecular imaging modalities hold great potential as less invasive techniques for diagnosis and management of various diseases.Molecular imaging combines imaging agents with targeting moieties to specifically image diseased sites in the body.Monoclonal antibodies (mAbs) have become increasingly popular as novel therapeutics against a variety of diseases due to their specificity, affinity and serum stability.Because of the same properties, mAbs are also exploited in molecular imaging to target imaging agents such as radionuclides to the cell of interest in vivo.Many studies investigated the use of mAb-targeted imaging for a variety of purposes, for instance to monitor disease progression and to predict response to a specific therapeutic agent.Herein, we highlighted the application of mAb-targeted imaging in three different types of pathologies: autoimmune diseases, oncology and cardiovascular diseases.We also described the potential of molecular imaging strategies in theranostics and precision medicine.Due to the nearly infinite repertoire of mAbs, molecular imaging can change the future of modern medicine by revolutionizing diagnostics and response prediction in practically any disease.
Government hands Amazon free access to NHS information
Authors: Elisabeth Mahase
Journal: BMJ (2019)

Amazon has been given access to all “healthcare information” of the NHS in England except patients’ records, shows a government contract obtained through freedom of information legislation.

The technology company, which has an estimated market value of $900bn (£685bn), has access to all the information free of charge, despite the data being gathered at taxpayers’ expense.

The contract, obtained by the charity Privacy International and revealed by the Sunday Times ,1 specifies that Amazon has access to “symptoms, causes and definitions” and to “all related copyrightable content and data and other materials.” It can use the data to develop, advertise, and sell “new products, applications, cloud-based services and/or distributed software.”

Amazon told The BMJ that all the information provided through this deal was …
Subcutaneous panniculitis-like T-cell lymphoma: a supraregional UK centre retrospective review
Authors: S. Winters, L. Menasce, P. Shenjere, L. Motta, L. Jamieson, R. Green, T. Illidge, E. Smith, A. Bloor, R. Cowan, E. Parry
Journal: British Journal of Dermatology (2019)
Arsenic Trioxide Shows Synergistic Anti-Myeloma Effects When Combined with Bortezomib and Melphalan In Vitro and Helps Overcome Resistance of Multiple Myeloma Cells to These Treatments in Vivo.
Authors: Richard A. Campbell, Haiming Chen, Daocheng Zhu, Janice C. Santos, Benjamin Bonavida, Shen Pang, Jonathan Said, James R. Berenson
Journal: Blood (2004)
Responses to Induction Chemotherapy and High Dose Melphalan Can Be Incorporated within a Risk Stratification Model and Help to Identify Myeloma Patients Who May Benefit from Novel Therapies.
Authors: Caroline L. Alvares, Faith E. Davies, Clive Horton, Gita Patel, Roslin Zuha, Alex Gatt, Radovan Saso, Jennifer Treleaven, Mark Ethell, Mike Potter, Claire Dearden, Gareth J. Morgan
Journal: Blood (2004)
Pembrolizumab vs chemotherapy in patients with advanced/metastatic adenocarcinoma (AC) or squamous cell carcinoma (SCC) of the esophagus as second-line therapy: Analysis of the Chinese subgroup in KEYNOTE-181
Authors: J. Chen, S. Luo, S. Qin, Y. Cheng, Z. Li, Y. Fan, X. Yuan, W. Li, Y. Sun, X. Yin, X. Lin, Y. Bai, T. Liu, J. Zhang, Y. Cui, P. Bhagia, S.P. Kang, W. Lu, Y. Zhou, L. Shen
Journal: Annals of Oncology (2019)
The combination of bevacizumab/Avastin and erlotinib/Tarceva is relevant for the treatment of metastatic renal cell carcinoma: the role of a synonymous mutation of the EGFR receptor
Authors: Renaud Grépin, Mélanie Guyot, Aurore Dumond, Jérôme Durivault, Damien Ambrosetti, Jean-François Roussel, Florence Dupré, Hervé Quintens, Gilles Pagès
Journal: Theranostics (2019)

Metastatic clear cell renal cell carcinomas (mRCC) over-express the vascular endothelial growth factor (VEGF). Hence, the anti-VEGF antibody bevacizumab/Avastin (BVZ) combined with interferon alpha (IFN) was approved for the treatment of mRCC. However, approval was lost in July 2016 due to the absence of sustained efficacy. We previously showed that BVZ accelerates tumor growth in experimental models of mRCC in mice, results in part explained by down-regulation of the phospho tyrosine phosphatase receptor kappa (PTPRκ) in tumor cells. The epidermal growth factor receptor (EGFR) is a direct target of PTPRκ. Its down-regulation leads to constitutive activation of EGFR, an observation which prompted us to test the effect of the EGFR inhibitor erlotinib/Tarceva (ERLO) in addition to BVZ/IFN. The influence of the long non-coding RNA, EGFR-AS1, on ERLO efficacy was also addressed. Methods: The effect of BVZ/IFN/ERLO was tested on the growth of experimental tumors in nude mice. The presence of germline mutation in the EGFR was evaluated on cell lines and primary RCC cells. In vitro translation and transfections of expression vectors coding the wild-type or the EGFR mutated gene in HEK-293 cells were used to test the role of EGFR mutation of the ERLO efficacy. Correlation between EGFR/EGFR-AS1 expression and survival was analyzed with an online available data base (TCGA). Results: Tumor growth was strongly reduced by the triple combination BVZ/IFN/ERLO and linked to reduced levels of pro-angiogenic/pro-inflammatory cytokines of the ELR+CXCL family and to subsequent inhibition of vascularization, a decreased number of lymphatic vessels and polarization of macrophages towards the M1 phenotype. Cells isolated from surgical resection of human tumors presented a range of sensitivity to ERLO depending on the presence of a newly detected mutation in the EGFR and to the presence of EGFR-AS1. Conclusions: Our results point-out that the BVZ/IFN/ERLO combination deserves testing for the treatment of mRCC that have a specific mutation in the EGFR.
心肌梗死患者应当吸氧吗？根据生理机制并且没有吸氧有害的证据：应该吸氧
Authors: Dan, Atar, 杜昕
Journal: BMJ (2010)

近期发表的一篇系统性综述显示，吸氧不能减轻急性心肌梗死患者的胸痛症状或改善其生存率，反而可能有害。毫无疑问，这一结论会引起医学界的关注，但这篇文章的研究结果是否可靠，它对临床实践又有何意义，值得深入分析。
Regulation of the germinal center and humoral immunity by interleukin-21
Authors: Stuart G. Tangye, Cindy S. Ma
Journal: The Journal of Experimental Medicine (2019)

Cytokines play critical roles in regulating the development, survival, differentiation, and function of immune cells. Cytokines exert their function by binding specific receptor complexes on the surface of immune cells and activating intracellular signaling pathways, thereby resulting in induction of specific transcription factors and regulated expression of target genes. While the function of cytokines is often fundamental for the generation of robust and effective immunity following infection or vaccination, aberrant production or function of cytokines can underpin immunopathology. IL-21 is a pleiotropic cytokine produced predominantly by CD4+ T cells. Gene-targeting studies in mice, in vitro analyses of human and murine lymphocytes, and the recent discoveries and analyses of humans with germline loss-of-function mutations in IL21 or IL21R have revealed diverse roles of IL-21 in immune regulation and effector function. This review will focus on recent advances in IL-21 biology that have highlighted its critical role in T cell–dependent B cell activation, germinal center reactions, and humoral immunity and how impaired responses to, or production of, IL-21 can lead to immune dysregulation.
High Throughput Proteomic Analysis of 559 Acute Myelogenous Leukemia (AML) Patient Samples on a Single Slide Using Reverse Phase Proteins Arrays (RPPA): Analysis of Signal Transduction Pathway (STP) and Apoptosis Regulating Proteins.
Authors: Steven M. Kornblau, YiHua Qiu, Raoul Tibes, Wenjing Chen, Elizabeth Lemker, Michael Andreeff, Kevin R. Coombes, Gordon B. Mills
Journal: Blood (2006)
Clinical Outcome by Acute Graft-Versus Host Disease (GVHD) Prophylaxis in Patients Underwent Allogeneic Bone Marrow Transplantation from Unrelated Donors: Nationwide Survey in Japan.
Authors: Masamichi Hara, Toshio Wakayama, Hiroatsu Ago, Teruhiko Kozuka, Yuichiro Nawa, Koji Iwato, Hiroshi Sao, Shinichiro Okamoto, Hisashi Sakamaki, Takakazu Kawase, Yasuo Morishima, Yoshihisa Kodera
Journal: Blood (2007)
软饮料、果糖消耗和男性痛风发生的风险：前瞻性队列研究
Authors: Hyon, Choi, Gary, Curhan, 黄程锦, 方卫纲, 曾学军
Journal: BMJ (2008)

目的 研究摄入含糖软饮料和果糖与男性痛风发生风险之间的关系。 设计 历时12年的前瞻性队列研究。 地点 医务人员随诊研究。 参与者 46393例无痛风病史的男性，通过填写经验证有效的食物频度调查表，提供他们摄入软饮料和果糖的信息。 结局评估指标 符合美国风湿病学院痛风调查标准的痛风新发病例。 结果 在12年的随访中，共报告新发痛风确诊病例755例。含糖软饮料摄入增多和痛风危险性升高相关。与每月饮用不足一份含糖软饮料相比，每周饮用5～6份的人发生痛风的多变量相对危险度是1．29（95％可信区间1．00～1．68），每天一份的是1．45（1．02～2．08），每天两份或两份以上的是1．85（1．08～3．16；趋势P值=0．002）。无糖软饮料和痛风发生的危险性无关（趋势P值=0．99）。摄入果糖每增加五分之一，相应的痛风发生的多变量相对危险度为1．00、1．29、1．41、1．84和2．02（1．49～2．75；趋势P值〈0．001）。摄入果糖的其他主要来源，比如所有种类的果汁或富含果糖的水果（苹果和橘子），也和痛风发生的风险升高相关（趋势P值〈0．05）。 结论 前瞻性数据提示摄入含糖软饮料和果糖与男性痛风发生风险升高显著相关。另外，富含果糖的水果和果汁也可以增加其危险性。无糖软饮料和痛风发生的危险性无关。
糖尿病基础知识（二） 糖尿病视网膜病变
Authors: PeterJWatkins, 李玉秀, 王姮
Journal: BMJ (2004)

失明是糖尿病最严重的并发症之一，也是最容易预防的并发症。年龄30～39岁人群组中糖尿病是导致失明的常见原因。糖尿病起病20年之后，几乎所有的1型糖尿病和60％以上的2型糖尿病患者都会出现一定程度的视网膜病变，甚至在2型糖尿病诊断之时大约1／4的患者已经存在背景期视网膜病变。目前的治疗措施能够预防绝大多数患者发生失明，因此在患者视力受损之前确定视网膜病变十分重要。
Abstract 894: Stent Fracture Detected by Multislice Computed Tomography after In-Stent Restenosis Caused by “full Metal Jacket” with Drug-Eluting Stents
Authors: Masashi Kimura, Tsuyoshi Ito, Mariko Ehara, Kenya Nasu, Yoshihisa Kinoshita, Mitsuyasu Terashima, Hitoshi Matsuo, Etsuo Tsuchikane, Tetsuo Matsubara, Keiko Asakura, Yasushi Asakura, Osamu Katoh, Takahiko Suzuki
Journal: Circulation (2008)

Background: Stented segment length and multiple stents are predictive factors for restenosis after drug-eluting stent (DES) implantation; coronary stent fracture has been noticed as a cause of in-s...
The Capacity of the Hypomethylating Agents Azacytidine and Decitabine to Induce Apoptosis and Cell Cycle Arrest Depends on the Activation of the DNA-Damage Response Pathway.
Authors: Simone Boehrer, Lionel Ades, Nicolas Tajeddine, Lorenzo Galluzzi, Stephane de Botton, Pierre Fenaux, Guido Kroemer
Journal: Blood (2008)
Proton Pump Inhibition for Secondary Hemochromatosis in Hereditary Anemia, a Phase III Placebo Controlled Randomized Cross-over Trial in Progress
Authors: Annelies J. Van Vuren, Bart J. Biemond, Jean-Louis Kerkhoffs, Saskia E.M. Schols, A. W. Rijneveld, Erfan Nur, Richard van Wijk, Tim Leiner, Joannes J.M. Marx, Eduard J. van Beers
Journal: Blood (2019)
Impact of Cancer on Employment
Authors: Victoria S. Blinder, Francesca M. Gany
Journal: Journal of Clinical Oncology (2019)

Article Tools REVIEW ARTICLES Health Services and Outcomes Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.19.01856 Journal of Clinical Oncology - published online before print December 5, 2019 PMID: 31804857 Impact of Cancer on Employment Victoria S. Blinder, MD, MSc1xVictoria S. BlinderSearch for articles by this author and Francesca M. Gany, MD, MSc1xFrancesca M. GanySearch for articles by this author Show More 1Memorial Sloan Kettering Cancer Center, New York, NY https://doi.org/10.1200/JCO.19.01856 First Page Full Text PDF Figures and Tables © 2019 by American Society of Clinical Oncology
Machine Learning to Detect Alzheimer’s Disease from Circulating Non-Coding RNAs
Authors: Nicole Ludwig, Tobias Fehlmann, Fabian Kern, Manfred Gogol, Walter Maetzler, Stephanie Deutscher, Simone Gurlit, Claudia Schulte, Anna-Katharina von Thaler, Christian Deuschle, Florian Metzger, Daniela Berg, Ulrike Suenkel, Verena Keller, Christina Backes, Hans-Peter Lenhof, Eckart Meese, Andreas Keller
Journal: Genomics Proteomics & Bioinformatics (2019)

Abstract Blood-borne small non-coding (sncRNAs) are among the prominent candidates for blood-based diagnostic tests. Often, high-throughput approaches are applied to discover biomarker signatures. These have to be validated in larger cohorts and evaluated by adequate statistical learning approaches. Previously, we published high-throughput sequencing based microRNA (miRNA) signatures in Alzheimer’s disease (AD) patients in the United States (US) and Germany. Here, we determined abundance levels of 21 known circulating miRNAs in 465 individuals encompassing AD patients and controls by RT-qPCR. We computed models to assess the relation between miRNA expression and phenotypes, gender, age, or disease severity (Mini-Mental State Examination; MMSE). Of the 21 miRNAs, expression levels of 20 miRNAs were consistently de-regulated in the US and German cohorts. 18 miRNAs were significantly correlated with neurodegeneration (Benjamini-Hochberg adjusted P &amp;lt; 0.05) with highest significance for miR-532-5p (Benjamini-Hochberg adjusted P = 4.8 × 10−30). Machine learning models reached an area under the curve (AUC) value of 87.6% in differentiating AD patients from controls. Further, ten miRNAs were significantly correlated with MMSE, in particular miR-26a/26b-5p (adjusted P = 0.0002). Interestingly, the miRNAs with lower abundance in AD were enriched in monocytes and T-helper cells, while those up-regulated in AD were enriched in serum, exosomes, cytotoxic t-cells, and B-cells. Our study represents the next important step in translational research for a miRNA-based AD test.
Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis
Authors: Dan A. Erkes, Weijia Cai, Ileine M. Sanchez, Timothy J. Purwin, Corey Rogers, Conroy O. Field, Adam C. Berger, Edward J. Hartsough, Ulrich Rodeck, Emad S. Alnemri, Andrew E. Aplin
Journal: Cancer Discovery (2019)

Combinations of BRAF inhibitors and MEK inhibitors (BRAFi + MEKi) are FDA-approved to treat BRAF V600E/K-mutant melanoma. Efficacy of BRAFi + MEKi associates with cancer cell death and alterations in the tumor immune microenvironment; however, the links are poorly understood. We show that BRAFi + MEKi caused durable melanoma regression in an immune-mediated manner. BRAFi + MEKi treatment promoted cleavage of gasdermin E (GSDME) and release of HMGB1, markers of pyroptotic cell death. GSDME-deficient melanoma showed defective HMGB1 release, reduced tumor-associated T cell and activated dendritic cell infiltrates in response to BRAFi + MEKi, and more frequent tumor regrowth after drug removal. Importantly, BRAFi + MEKi-resistant disease lacked pyroptosis markers and showed decreased intratumoral T-cell infiltration but was sensitive to pyroptosis-inducing chemotherapy. These data implicate BRAFi + MEKi-induced pyroptosis in antitumor immune responses and highlight new therapeutic strategies for resistant melanoma. SIGNIFICANCE: Targeted inhibitors and immune checkpoint agents have advanced the care of patients with melanoma; however, detailed knowledge of the intersection between these two research areas is lacking. We describe a molecular mechanism of targeted inhibitor regulation of an immune-stimulatory form of cell death and provide a proof-of-principle salvage therapy concept for inhibitor-resistant melanoma.See related commentary by Smalley, p. 176.This article is highlighted in the In This Issue feature, p. 161.
Bracing for the Worst — Range Expansion of the Lone Star Tick in the Northeastern United States
Authors: Goudarz Molaei, Eliza A.H. Little, Scott C. Williams, Kirby C. Stafford
Journal: New England Journal of Medicine (2019)

Bracing for the Worst Increasing population densities and subsequent range expansion, in conjunction with nondiscriminating biting habits and the capacity to transmit diverse pathogens, position th...
A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia
Authors: Andrei V. Krivtsov, Kathryn Evans, Jayant Y. Gadrey, Benjamin K. Eschle, Charlie Hatton, Hannah J. Uckelmann, Kenneth N. Ross, Florian Perner, Sarah N. Olsen, Tara Pritchard, Lisa McDermott, Connor D. Jones, Duohui Jing, Ali Braytee, Diego Chacon, Eric Earley, Brian M. McKeever, David Claremon, Andrew J. Gifford, Heather J. Lee, Beverly A. Teicher, John E. Pimanda, Dominik Beck, Jennifer A. Perry, Malcolm A. Smith, Gerard M. McGeehan, Richard B. Lock, Scott A. Armstrong
Journal: Cancer Cell (2019)
Ixekizumab for patients with non-radiographic axial spondyloarthritis (COAST-X): a randomised, placebo-controlled trial
Authors: Atul Deodhar, Désirée van der Heijde, Lianne S Gensler, Tae-Hwan Kim, Walter P Maksymowych, Mikkel Østergaard, Denis Poddubnyy, Helena Marzo-Ortega, Louis Bessette, Tetsuya Tomita, Ann Leung, Maja Hojnik, Gaia Gallo, Xiaoqi Li, David Adams, Hilde Carlier, Joachim Sieper, Frederic Morin, Proton Rahman, Federico Ariel, Alberto Berman, Judith Carrio, Eleonora Lucero, Jose Maldonado Cocco, Rodolfo Pardo Hidalgo, Jorge Velasco, Diego O. Viola, Johannes Grisar, Heinrich Resch, Clemens Scheinecker, Ana Claudia Melazzi, Luis Roimicher, Antonio Scafuto Scotton, Aaron Alejandro Barrera Rodriguez, Francisco Fidencio Cons Molina, Sergio Duran Barragan, Cassandra M. Skinner, Cesar Francisco Pacheco Tena, Cesar Ricardo Ramos Remus, Juan Cruz Rizo Rodriguez, Seung-Jae Hong, Seong Wook Kang, Chang Keun Lee, Eun Bong Lee, Sang Heon Lee, Min-Chan Park, Sang-Hoon Lee, Eva Dokoupilova, Zdenek Dvorak, Martina Malcova, Karel Pvelka, Kari K. Eklund, Pentti Jarvinen, Anna Karjalainen, Leena Paimela, Yoshinori Taniguchi, Tokutaro Tsuda, Kurisu Tada, Hiroaki Dobashi, Kentaro Inui, Yukitaka Ueki, Yoshifuji Matsumoto, Kazuhiro Hatta, Tatsuya Atsumi, Hitoshi Goto, Shigeru Honjo, Kiyoshi Matsui, Yuya Takakubo, Gunther Neeck, Sylke Wagner, Jürgen Braun, Tomasz Blicharshi, Anna Dudek, Pawel Hrycai, Rafal Plebanski, Janina Drabiszcak-Piatkowska, Jan Brzezicki, Marek Krogulec, Daniela Opris-Belinski, Ana Maria Ramazan, Luminita Tronaru, Marleen G. van de Sande, Galina Matsievskaya, Evgeniya Schmidt, Marina Stanislav, Sergey Yakushin, Olga Ershova, Andrey Rebroy, Melvin A. Churchill, Kathleen P. Flint, Maria Greenwald, Mary P. Howell, Jeffrey L. Kaine, Alan Kivitz, Steven J. Klein, Eric C. Mueller, Eric A. Peters, Roel Querubin, Michael E. Sayers, Craig D. Scoville, Joseph C. Shanahan, Richard Roseff, John E. Hull, Jyothi R. Mallepalli, Mohamed B. Sebai, Steven C. Kimmel, David H. Goddard, Philip J. Mease, Mark D. Harris, Arthur R. Mabaquiao, Roger J. Diegel, Christine Thai, Tania L. Rivera, Amarilis Perez-De Jesus, Oscar Soto-Raices, Ramon Toro-Torres, Carlos Pantojas
Journal: The Lancet (2019)
A Histone Deacetylase Inhibitor Induces Apoptosis, Differentiation and Cell Cycle Changes in STI571 Resistant CML Cell Line with No Change in BCR-ABL Expression
Authors: Matityahu Shaklai, Yael Zimra, Inessa Belyaeva, Adina Aviram, Esther Rabizadeh
Journal: Blood (2008)
Non-Genotoxic Anti-CD117 Antibody Conditioning Results in Successful Hematopoietic Stem Cell Engraftment in Patients with Severe Combined Immunodeficiency
Authors: Rajni Agarwal, Christopher C. Dvorak, Hye-Sook Kwon, Janel R Long-Boyle, Susan S Prohaska, Janice W Brown, Anne Le, Alyssa Guttman-Klein, Irving L Weissman, Morton J Cowan, Aaron C. Logan, Kenneth I. Weinberg, Robertson Parkman, Maria-Grazia Roncarolo, Judith A Shizuru
Journal: Blood (2019)
Abstract 13935: Vascular Modulation of Adipose Function: Role of Endothelial Argonaute 1
Authors: Xiaofang Tang, Yifei Miao, Zhijie Qi, Kendall Van Keuren-Jensen, Gene Yeo, Rama Natarajan, Sheng Zhong, Zhen Chen
Journal: Circulation (2019)

Introduction: Metabolic disorders such as obesity and diabetes can cause dysfunction of endothelial cells (ECs) and impaired vascularization in adipose tissues. However, the modulatory role of ECs ...
SABINA: global programme to evaluate prescriptions and clinical outcomes related to short-acting β<sub>2</sub>-agonist use in asthma
Authors: Claudia S. Cabrera, Cassandra Nan, Niklas Lindarck, Maarten J.H.I. Beekman, Sofie Arnetorp, Ralf J.P. van der Valk
Journal: European Respiratory Journal (2019)

<b>As SABA overuse is associated with exacerbations and mortality, GINA no longer recommends SABA only as a preferred reliever in asthma. A consistent pattern of high SABA use from the SABINA programme would indicate a global public health issue.</b>http://bit.ly/33XDrlb