tbuckley/cabot-search huggingface dataset:
Abstract 9625: Late Malapposition and Endothelial Coverage of Drug-Eluting-Stents - A Prospective Optical Coherence Tomography Study
Authors: Christian Roth, Clemens Gangl, Daniel Dalos, Lisa Krenn, Sabine Scherzer, Irene Lang, Gerhard Kreiner, Georg Delle-Karth, Thomas Neunteufl, Rudolf Berger
Journal: Circulation (2013)

Background: Uncovered stent struts of drug-eluting stents (DES) are associated with late stent thrombosis. Early and late malapposition of stent struts may be the major mechanisms for uncovered struts. Data regarding coverage of malapposed struts are missing. Aims: This study examines malapposition of DES and the coverage of late malapposed struts in patients who underwent elective percutaneous coronary intervention (PCI). Methods: Fifty patients treated with 60 DES (25 Everolimus-eluting stents [EES], 18 Zotarolimus-eluting stents [ZES], 17 Biolimus-eluting stents [BES]) underwent optical coherence tomography (OCT) directly after implantation and after 12 months. Results: Postintervention acute stent malapposition (ASM) occurred in 30 stents (50%). Of these, 21 stents (70%) resolved completely, whereas 6 stents resolved partly and 3 persisted completely after one year. At this time-point, a total of 15 stents (25%) with late stent malappositions (LSM) were detected due to late acquired stent malapposition (LASM) in additional 10 stents (Table 1). Twelve of these 15 stents showed complete or almost complete (&gt;80%) coverage of the malapposed struts, whereas 3 stents had no coverage of any malapposed strut (Table 2). Conclusion: A quarter of electively implanted DES is associated with LSM. Uncoverage of malapposed struts applies only to a minority of stents with LSM. The reason for coverage/uncoverage and the clinical impact has to be determined.
Incidence and Lethality of Suicidal Overdoses by Drug Class
Authors: Ted R. Miller, David I. Swedler, Bruce A. Lawrence, Bina Ali, Ian R. H. Rockett, Nancy N. Carlson, Jennifer Leonardo
Journal: JAMA Network Open (2020)

Prior lethality analyses of suicide means have historically treated drug poisoning other than alcohol poisoning as a lumped category. Assessing risk by drug class permits better assessment of prevention opportunities.
THE IMPACT OF GRADIENT AND FLOW ON THE OUTCOMES OF TAVR IN SEVERE AORTIC STENOSIS WITH PRESERVED LEFT VENTRICULAR EJECTION FRACTION
Authors: Mohamad Kabach, Abdulah Alrifai, Jesus Pino, Pradeep Dayanand, Edwin Grajeda, Lawrence Lovitz, Mark Rothenberg, Roberto Cubeddu, Cristiano Faber, Marcos Nores, Zaher Fanari
Journal: Journal of the American College of Cardiology (2018)
scAI: an unsupervised approach for the integrative analysis of parallel single-cell transcriptomic and epigenomic profiles
Authors: Suoqin Jin, Lihua Zhang, Qing Nie
Journal: Genome biology (2020)

Abstract Simultaneous measurements of transcriptomic and epigenomic profiles in the same individual cells provide an unprecedented opportunity to understand cell fates. However, effective approaches for the integrative analysis of such data are lacking. Here, we present a single-cell aggregation and integration (scAI) method to deconvolute cellular heterogeneity from parallel transcriptomic and epigenomic profiles. Through iterative learning, scAI aggregates sparse epigenomic signals in similar cells learned in an unsupervised manner, allowing coherent fusion with transcriptomic measurements. Simulation studies and applications to three real datasets demonstrate its capability of dissecting cellular heterogeneity within both transcriptomic and epigenomic layers and understanding transcriptional regulatory mechanisms.
The effect of control strategies to reduce social mixing on outcomes of the COVID-19 epidemic in Wuhan, China: a modelling study
Authors: Kiesha Prem, Yang Liu, Timothy W Russell, Adam J Kucharski, Rosalind M Eggo, Nicholas Davies, Mark Jit, Petra Klepac, Stefan Flasche, Samuel Clifford, Carl A B Pearson, James D Munday, Sam Abbott, Hamish Gibbs, Alicia Rosello, Billy J Quilty, Thibaut Jombart, Fiona Sun, Charlie Diamond, Amy Gimma, Kevin van Zandvoort, Sebastian Funk, Christopher I Jarvis, W John Edmunds, Nikos I Bosse, Joel Hellewell
Journal: The Lancet Public Health (2020)
Mature myelin maintenance requires Qki to coactivate PPARβ-RXRα–mediated lipid metabolism
Authors: Xin Zhou, Chenxi He, Jiangong Ren, Congxin Dai, Sharon R. Stevens, Qianghu Wang, Daniel Zamler, Takashi Shingu, Liang Yuan, Chythra R. Chandregowda, Yunfei Wang, Visweswaran Ravikumar, Arvind U.K. Rao, Feng Zhou, Hongwu Zheng, Matthew N. Rasband, Yiwen Chen, Fei Lan, Amy B. Heimberger, Benjamin M. Segal, Jian Hu
Journal: Journal of Clinical Investigation (2020)

Lipid-rich myelin forms electrically insulating, axon-wrapping multilayers that are essential for neural function, and mature myelin is traditionally considered metabolically inert. Surprisingly, we discovered that mature myelin lipids undergo rapid turnover, and quaking (Qki) is a major regulator of myelin lipid homeostasis. Oligodendrocyte-specific Qki depletion, without affecting oligodendrocyte survival, resulted in rapid demyelination, within 1 week, and gradually neurological deficits in adult mice. Myelin lipids, especially the monounsaturated fatty acids and very-long-chain fatty acids, were dramatically reduced by Qki depletion, whereas the major myelin proteins remained intact, and the demyelinating phenotypes of Qki-depleted mice were alleviated by a high-fat diet. Mechanistically, Qki serves as a coactivator of the PPARβ-RXRα complex, which controls the transcription of lipid-metabolism genes, particularly those involved in fatty acid desaturation and elongation. Treatment of Qki-depleted mice with PPARβ/RXR agonists significantly alleviated neurological disability and extended survival durations. Furthermore, a subset of lesions from patients with primary progressive multiple sclerosis were characterized by preferential reductions in myelin lipid contents, activities of various lipid metabolism pathways, and expression level of QKI-5 in human oligodendrocytes. Together, our results demonstrate that continuous lipid synthesis is indispensable for mature myelin maintenance and highlight an underappreciated role of lipid metabolism in demyelinating diseases.
DECONGESTION STRATEGIES AND RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM ACTIVATION IN ACUTE HEART FAILURE
Authors: Robert J. Mentz, Susanna Stevens, Anu Lala, Justin Vader, Adam DeVore, Omar AbouEzzeddine, Prateeti Khazanie, Steven McNulty, Kevin Anstrom, Margaret Redfield, Christopher O'Connor, Lynne Stevenson, Steven Goldsmith, Monica Shah, Bradley Bart, Adrian Hernandez, Eugene Braunwald, G. Michael Felker
Journal: Journal of the American College of Cardiology (2014)
TCTAP A-116 Long-term Clinical Follow-up of Percutaneous Transluminal Angioplasty for Lower Extremity Arterial Insufficiency in Patients with Reduced Left Ventricular Function
Authors: Ahmed Mashaly, Seung-Woon Rha, Byoung Geol Choi, Se Yeon Choi, Ja Kyeong Byun, Kareem Abdelshafi, Yoonjee Park, Dong Oh Kang, Won Young Jang, Woohyeun Kim, Eun Jin Park, Jin Oh Na, Cheolung Choi, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo
Journal: Journal of the American College of Cardiology (2019)
HKDC1 C-terminal based peptides inhibit extranodal natural killer/T-cell lymphoma by modulation of mitochondrial function and EBV suppression
Authors: Qi Chen, Jia Feng, Jinhu Wu, Zhendong Yu, Wei Zhang, Yonggang Chen, Paul Yao, Hongyu Zhang
Journal: Leukemia (2020)

Extranodal nasal-type natural killer/T-cell lymphoma (ENKTL) is an Epstein-Barr virus (EBV) associated lymphoma that progresses rapidly and relapses frequently. Advanced ENKTL is multidrug chemoresistant and has a poor prognosis. In this study, we aim to develop a novel hexokinase domain component 1 (HKDC1)-based antitumor target for ENKTL that is involved with the antimetabolic signaling pathway, EBV replication, and P-glycoprotein (P-gp) expression. We showed that HKDC1 is highly upregulated in ENKTL cells and HKDC1 knockdown significantly suppresses ENKTL tumor growth. In addition, HKDC1 is highly identical with four other hexokinase isoforms, with the only difference being in the last eight amino acids (aa) at the C-terminal. Further investigation showed that peptide delivery of the last eight aa of HKDC1 at the C-terminal (HKC8) with D-configuration using transferrin (Tf) receptor internalization sequence (Tf-D-HKC8) inhibits HKDC1 association with vascular endothelial growth factor 1 (VDAC1), resulting in mitochondrial dysfunction and reactive oxygen species (ROS) overgeneration and subsequently suppressing EBV replication and P-gp expression, making it very effective in killing EBV-positive ENKTL cells. Further in vivo experiments showed that local injection of Tf-D-HKC8 peptide significantly suppresses ENKTL tumor growth and EBV replication in ENKTL xenograft mouse models. We conclude that HKDC1 C-terminal-based peptides inhibit ENKTL by modulation of mitochondrial function and EBV suppression.
F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospects
Authors: Dinesh Singh Tekcham, Di Chen, Yu Liu, Ting Ling, Yi Zhang, Huan Chen, Wen Wang, Wuxiyar Otkur, Huan Qi, Tian Xia, Xiaolong Liu, Hai-long Piao, Hongxu Liu
Journal: Theranostics (2020)

E3 ubiquitin ligases play a critical role in cellular mechanisms and cancer progression.F-box protein is the core component of the SKP1-cullin 1-F-box (SCF)-type E3 ubiquitin ligase and directly binds to substrates by various specific domains.According to the specific domains, F-box proteins are further classified into three sub-families: 1) F-box with leucine rich amino acid repeats (FBXL); 2) F-box with WD 40 amino acid repeats (FBXW); 3) F-box only with uncharacterized domains (FBXO).Here, we summarize the substrates of F-box proteins, discuss the important molecular mechanism and emerging role of F-box proteins especially from the perspective of cancer development and progression.These findings will shed new light on malignant tumor progression mechanisms, and suggest the potential role of F-box proteins as cancer biomarkers and therapeutic targets for future cancer treatment.
PULMONARY VEIN ORIENTATION IS INDEPENDENTLY ASSOCIATED WITH OUTCOMES FOLLOWING CRYOBALLOON BASED ATRIAL FIBRILLATION ABLATION
Authors: Duygu Kocyigit, Muhammed Ulvi Yalcin, Kadri Gurses, Selin Ardalı, Gamze Turk, Ugur Canpolat, Banu Evranos, Hikmet Yorgun, Mehmet Levent Sahiner, Ergun Barıs Kaya, Tuncay Hazirolan, Kudret Aytemir
Journal: Journal of the American College of Cardiology (2018)
Preserving Clinical Trial Integrity During the Coronavirus Pandemic
Authors: Mary M. McDermott, Anne B. Newman
Journal: JAMA (2020)

Preserving Clinical Trial Integrity During the Coronavirus PandemicRandomized clinical trials provide the highestquality evidence for identifying therapies to help people attain longer and healthier lives.As of March 2020, ClinicalTrials.govlisted 262 366 ongoing randomized clinical trials, including 146 420 trials studying drug or biologic interventions, 85 045 trials of behavioral interventions, and 61 351 trials of surgical or device interventions. 1 Suddenly, and quite dramatically, the coronavirus pandemic threatens the integrity of these clinical trials.The National Institutes of Health has advised investigators to consult with their institutional review boards and institutions about potential measures to protect participants and research staff.Responses from academic medical center and other research groups have varied from mandatory suspension of research involving human participants (except when this increases risk to participants) to relying on principal investigator discretion.Coronavirus mitigation efforts include selfisolation and avoiding health care centers where symptomatic patients congregate for medical care and where randomized trials are typically conducted.Mitigation efforts interfere with all aspects of a successful clinical trial: efficient accrual and randomization, intervention
EXERCISE TRAINING AND IMPLANTABLE CARDIOVERTER DEFIBRILLATOR SHOCKS IN PATIENTS WITH HEART FAILURE: RESULTS FROM HF-ACTION
Authors: Jonathan P. Piccini, Anne S. Hellkamp, David J. Whellan, Stephan J. Ellis, Steven J. Keteyian, Lawton Cooper, William E. Kraus, Ileana L. Piña, Christopher M. O’Connor
Journal: Journal of the American College of Cardiology (2010)
Emergence of ceftazidime/avibactam resistance in KPC-8–producing Klebsiella pneumoniae in South America
Authors: J. García, M. Nastro, D. Cejas, G. Santana, M.B. Mancino, M. Hidalgo, G. Maccallini, C. Vay, M. Radice, L. Dabos, A. Famiglietti, H. Rodríguez
Journal: Clinical Microbiology and Infection (2020)
Association Between Medicaid Expansion and Rates of Opioid-Related Hospital Use
Authors: Hefei Wen, Aparna Soni, Alex Hollingsworth, Seth Freedman, Joseph Benitez, Kosali Simon, Brendan Saloner
Journal: JAMA Internal Medicine (2020)

The rate of opioid-related emergency department (ED) visits and inpatient hospitalizations has increased rapidly in recent years. Medicaid expansions have the potential to reduce overall opioid-related hospital events by improving access to outpatient treatment for opioid use disorder.To examine the association between Medicaid expansions and rates of opioid-related ED visits and inpatient hospitalizations.A difference-in-differences observational design was used to compare changes in opioid-related hospital events in US nonfederal, nonrehabilitation hospitals in states that implemented Medicaid expansions between the first quarter of 2005 and the last quarter of 2017 with changes in nonexpansion states. All-payer ED and hospital discharges from 45 states in the Healthcare Cost and Utilization Project FastStats were included.State implementation of Medicaid expansions between 2005 and 2017.Rates of all opioid-related ED visits and inpatient hospitalizations, measured as the quarterly numbers of treat-and-release ED discharges and hospital discharges related to opioid abuse, dependence, and overdose, per 100 000 state population.In the 46 states and District of Columbia included in the study, 1524 observations of emergency department data and 2219 observations of opioid-related inpatient hospitalizations were analyzed. The post-2014 Medicaid expansions were associated with a 9.74% (95% CI, -18.83% to -0.65%) reduction in the rate of opioid-related inpatient hospitalizations. There appeared to be no association between the pre-2014 or post-2014 Medicaid expansions and the rate of opioid-related ED visits (post-2014 Medicaid expansions, -3.98%; 95% CI, -14.69% to 6.72%; and pre-2014 Medicaid expansions, 1.02%; 95% CI, -5.25% to 7.28%).Medicaid expansion appears to be associated with meaningful reductions in opioid-related hospital use, possibly attributable to improved care for opioid use disorder in other settings.
High-Density Lipoproteins Are the Main Carriers of PCSK9 in the Circulation
Authors: Sean A. Burnap, Abhishek Joshi, Sotirios Tsimikas, Carlos Fernández-Hernando, Stefan Kiechl, Sarah E. Berry, Wendy Hall, Bodo Levkau, Manuel Mayr
Journal: Journal of the American College of Cardiology (2020)
Seven-Year Experience From the National Institute of Neurological Disorders and Stroke–Supported Network for Excellence in Neuroscience Clinical Trials
Authors: Merit Cudkowicz, Marianne K. Chase, Christopher S. Coffey, Dixie J. Ecklund, Brenda J. Thornell, Codrin Lungu, Katy Mahoney, Laurie Gutmann, Jeremy M. Shefner, Kevin J. Staley, Michael Bosch, Eric Foster, Jeffrey D. Long, Emine O. Bayman, James Torner, Jon Yankey, Richard Peters, Trevis Huff, Robin A. Conwit, Shlomo Shinnar, Donna Patch, Basil T. Darras, Audrey Ellis, Roger J. Packer, Karen S. Marder, Claudia A. Chiriboga, Claire Henchcliffe, Joyce Ann Moran, Blagovest Nikolov, Stewart A. Factor, Carole Seeley, Steven M. Greenberg, Anthony A. Amato, Sara DeGregorio, Tanya Simuni, Tina Ward, John T. Kissel, Stephen J. Kolb, Amy Bartlett, Joseph F. Quinn, Kellie Keith, Steven R. Levine, Nadege Gilles, Patricia K. Coyle, Jessica Lamb, Gil I. Wolfe, Annemarie Crumlish, Luis Mejico, Muhammad Maaz Iqbal, James D. Bowen, Caryl Tongco, Louis B. Nabors, Khurram Bashir, Melanie Benge, Craig M. McDonald, Erik K. Henricson, Björn Oskarsson, Bruce H. Dobkin, Catherine Canamar, Tracy A. Glauser, Daniel Woo, Angela Molloy, Peggy Clark, Timothy L. Vollmer, Alexander J. Stein, Richard J. Barohn, Mazen M. Dimachkie, Jean-Baptiste Le Pichon, Michael G. Benatar, Julie Steele, Lawrence Wechsler, Paula R. Clemens, Christine Amity, Robert G. Holloway, Christine Annis, Mark P. Goldberg, Mariam Andersen, Susan T. Iannaccone, A. Gordon Smith, J. Robinson Singleton, Mariana Doudova, E. Clarke Haley, Mark S. Quigg, Stephanie Lowenhaupt, Beth A. Malow, Karen Adkins, David B. Clifford, Mengesha A. Teshome, Noreen Connolly
Journal: JAMA Neurology (2020)

One major advantage of developing large, federally funded networks for clinical research in neurology is the ability to have a trial-ready network that can efficiently conduct scientifically rigorous projects to improve the health of people with neurologic disorders.
Covid-19: give NHS staff rest spaces and free parking not thank yous, says doctor
Authors: Abi Rimmer
Journal: BMJ (2020)

An NHS consultant has called for NHS staff working during the covid-19 pandemic to be rewarded with rest areas and free parking.

Speaking to LBC radio on 19 March the intensive care consultant known only as “Jack” called for staff who were “putting their lives on the line” treating patients during the pandemic to be properly rewarded.1

“All I want, rather than people saying thank you when this is finished, is for these people to be given a coffee room to sit in. To be given a kettle, coffee, milk. Maybe a Christmas dinner that’s paid for or given to them by the …
Critical Supply Shortages — The Need for Ventilators and Personal Protective Equipment during the Covid-19 Pandemic
Authors: Megan L. Ranney, Valerie Griffeth, Ashish K. Jha
Journal: New England Journal of Medicine (2020)

Critical Supply Shortages U.S. hospitals are already reporting shortages of key equipment needed to care for critically ill patients with Covid-19, including ventilators and personal protective equ...
CONSCIOUS SEDATION VERSUS GENERAL ANESTHESIA IN TRANSCATHETER AORTIC VALVE REPLACEMENT: THE GERMAN AORTIC VALVE REGISTRY
Authors: Oliver Husser, Buntaro Fujita, Christian Hengstenberg, Christian Frerker, Andreas Beckmann, Helge Möllmann, Thomas Walther, Raffi Bekeredjian, Michael Böhm, Costanza Pellegrini, Sabine Bleiziffer, Rüdiger Lange, Friedrich Mohr, Christian Hamm, Timm Bauer, Stephan Ensminger
Journal: Journal of the American College of Cardiology (2018)
Methotrexate-associated Lymphoproliferative Disorder of the Small Intestine
Authors: Hisashi Shiga, Izuru Abe, Atsushi Masamune
Journal: Clinical Gastroenterology and Hepatology (2020)

A 66-year-old woman with psoriatic arthritis was referred to our department for lower abdominal pain. She had been treated with methotrexate (MTX) for more than 12 years. Laboratory tests revealed iron deficiency anemia with a hemoglobin level of 8.7 g/dL and a slightly increased soluble interleukin-2 receptor level (638 U/mL; normal range, 145–519 U/mL). Abdominal enhanced computed tomography examination detected thickening of the wall of the distal ileum (Figure A), which was surrounded by swollen lymph nodes. Balloon-assisted enteroscopy revealed a large and irregular-shaped deep ulceration in the distal ileum (Figure B). Biopsy specimens revealed proliferation of CD20+ large B-lymphoid atypical cells in the granulation tissue (Figure C). In situ hybridization of the Epstein-Barr virus revealed positive signals and polymerase chain reaction of the immunoglobulin heavy chain gene showed monoclonality, consistent with the diagnosis of MTX-associated lymphoproliferative disorder. Six weeks after the cessation of MTX, no recurrent lesions were observed on balloon-assisted enteroscopy, with the exception of ulcer scar and tattooing (Figure D), and biopsy specimens revealed no atypical cells. If gastrointestinal diseases are detected in patients with the history of prolonged MTX use, one should consider MTX-associated lymphoproliferative disorder, which may be treated with the cessation of MTX alone.
TCT-200 The impact of presence of the chronic total occlusion on the prognosis of the patients with well-preserved left ventricular function after suffering from acute myocardial infarction
Authors: Yukio Mizuguchi, Akihiko Takahashi, Takeshi Yamada, Norimasa Taniguchi, Shunsuke Nakajima, Tetsuya Hata
Journal: Journal of the American College of Cardiology (2014)
More than Smoke and Patches: The Quest for Pharmacotherapies to Treat Tobacco Use Disorder
Authors: M. J. Moerke, L. R. McMahon, J. L. Wilkerson
Journal: Pharmacological Reviews (2020)

Tobacco use is a persistent public health issue. It kills up to half its users and is the cause of nearly 90% of all lung cancers. The main psychoactive component of tobacco is nicotine, primarily responsible for its abuse-related effects. Accordingly, most pharmacotherapies for smoking cessation target nicotinic acetylcholine receptors (nAChRs), nicotine's major site of action in the brain. The goal of the current review is twofold: first, to provide a brief overview of the most commonly used behavioral procedures for evaluating smoking cessation pharmacotherapies and an introduction to pharmacokinetic and pharmacodynamic properties of nicotine important for consideration in the development of new pharmacotherapies; and second, to discuss current and potential future pharmacological interventions aimed at decreasing tobacco use. Attention will focus on the potential for allosteric modulators of nAChRs to offer an improvement over currently approved pharmacotherapies. Additionally, given increasing public concern for the potential health consequences of using electronic nicotine delivery systems, which allow users to inhale aerosolized solutions as an alternative to smoking tobacco, an effort will be made throughout this review to address the implications of this relatively new form of nicotine delivery, specifically as it relates to smoking cessation. SIGNIFICANCE STATEMENT: Despite decades of research that have vastly improved our understanding of nicotine and its effects on the body, only a handful of pharmacotherapies have been successfully developed for use in smoking cessation. Thus, investigation of alternative pharmacological strategies for treating tobacco use disorder remains active; allosteric modulators of nicotinic acetylcholine receptors represent one class of compounds currently under development for this purpose.
Linked optical and gene expression profiling of single cells at high-throughput
Authors: Jesse Q. Zhang, Christian A. Siltanen, Leqian Liu, Kai-Chun Chang, Zev J. Gartner, Adam R. Abate
Journal: Genome biology (2020)

Single-cell RNA sequencing has emerged as a powerful tool for characterizing cells, but not all phenotypes of interest can be observed through changes in gene expression. Linking sequencing with optical analysis has provided insight into the molecular basis of cellular function, but current approaches have limited throughput. Here, we present a high-throughput platform for linked optical and gene expression profiling of single cells. We demonstrate accurate fluorescence and gene expression measurements on thousands of cells in a single experiment. We use the platform to characterize DNA and RNA changes through the cell cycle and correlate antibody fluorescence with gene expression. The platform's ability to isolate rare cell subsets and perform multiple measurements, including fluorescence and sequencing-based analysis, holds potential for scalable multi-modal single-cell analysis.