tbuckley/cabot-search huggingface dataset:
Hepatitis B Flare After Cessation of Nucleos(t)ide Analogue Therapy in HBeAg‐Negative Chronic Hepatitis B: To Retreat or Not to Retreat
Authors: Yun‐Fan Liaw
Journal: Hepatology (2020)

1Liver Research UnitChang Gung Memorial HospitalChang Gung University College of MedicineTaipeiTaiwan *Address Correspondence and Reprint Requests to: Yun‐Fan Liaw, M.D. Liver Research Unit, Chang Gung Memorial Hospital 199, Tung Hwa North Road Taipei, 105, Taiwan E‐mail: [email protected] Tel.: +886‐3‐3281200 ext. 8120
Invasive therapy improved angina health status in patients with high-risk stable coronary disease and more frequent angina
Authors: Eric R. Bates
Journal: Annals of Internal Medicine (2020)

ACP Journal Club18 August 2020Invasive therapy improved angina health status in patients with high-risk stable coronary disease and more frequent anginaEric R. Bates, MDEric R. Bates, MDUniversity of Michigan, Ann Arbor, MI, USA (E.R.B.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJ202008180-015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationSpertus JA, Jones PG, Maron DJ, et al. Health-status outcomes with invasive or conservative care in coronary disease. N Engl J Med. 2020;382:1408-19. https://pubmed.ncbi.nlm.nih.gov/32227753Clinical Impact RatingsCardiology: References1 Fihn SD, Gardin JM, Abrams J, et al. 2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease. Circulation. 2012;126:e354–471. [PMID: 23166211] Google Scholar2 Chacko L, Howard JP, Rajkumar C, et al. Effects of percutaneous coronary intervention on death and myocardial infarction stratified by stable and unstable coronary artery disease: a meta-analysis of randomized controlled trials. Circ Cardiovasc Qual Outcomes. 2020;13:e006363. [PMID: 32063040] Google Scholar3 Boden WE, O’Rourke RA, Teo KK, et al. Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med. 2007;356:1503-16. [PMID: 17387127] Google Scholar4 Frye RL, August P, Brooks MM, et al. A randomized trial of therapies for type 2 diabetes and coronary artery disease. N Engl J Med. 2009;360:2503-15. [PMID: 19502645] Google Scholar5 De Bruyne B, Pijls NHJ, Kalesan B, et al. Fractional flow reserve–guided PCI versus medical therapy in stable coronary disease. N Engl J Med. 2012;367:991-1001. [PMID: 22924638] Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Michigan, Ann Arbor, MI, USA (E.R.B.)Disclosures: The commentator has disclosed no conflicts of interest. The form can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M19-3045.This article was published at Annals.org on 4 August 2020. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 18 August 2020Volume 173, Issue 4Page: JC15KeywordsAnginaAngiographyCoronary arteriesCoronary revascularizationIschemiaQuality of lifeQuestionnairesRevascularizationStable coronary artery diseaseStenosis ePublished: 18 August 2020 Issue Published: 18 August 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Correspondence on ‘Recovery from COVID-19 in a patient with spondyloarthritis treated with TNF-alpha inhibitor etanercept. A report on a patient with COVID-19 with psoriatic arthritis receiving ustekinumab’
Authors: Francesco Messina, Francesca Pampaloni, Stefano Piaserico
Journal: Annals of the Rheumatic Diseases (2020)

Little or no work has been done on sociocultural beliefs and sexual activity of postmenopausal women in Nigeria. This study was carried out to assess socio-cultural beliefs and sexual activity among postmenopausal women in Ibadan NorthEast Local Government Area. A cross-sectional study was conducted among 522 postmenopausal women aged 40–65 years. An interviewer-administered questionnaire was used to collect data on sociodemographic characteristics, attitude to sociocultural beliefs regarding sexual activity and current sexual activity of respondents. Descriptive χ<sup>2</sup> and logistic regression were used for data analysis. The mean age of the respondents was 54.0±5.6 years. Overall, 45.7% agreed with at least one of the stated socio-cultural beliefs and the mean attitudinal score was 4.1±3.2. Among those who currently had partners, only 30.7% reported post-menopausal sexual activity. Significantly higher proportions of those with no formal education (78.6%), those aged ≥50 years (69.9%) and with supportive attitude towards the socio-cultural beliefs (83.8%) reported cessation of post-menopausal sexual activity (p&lt;0.05). The significant predictors for cessation of post-menopausal sexual activity were no formal education (OR=4.1, 95% CI from 2.0 to 8.3), supportive attitude towards socio-cultural beliefs (OR=5.6, 95% CI from 3.4 to 9.4) and older age group (OR=4.1, 95% CI from 2.4 to 7.0). Socio-cultural beliefs affected post-menopausal sexual activity among these women; this may result in their partners seeking for alternative sexual partners with the attendant problems of sexually transmitted infections. There is need for the development of educational interventions targeted at changing these beliefs.
Conservative oxygen therapy for mechanically ventilated adults with suspected hypoxic ischaemic encephalopathy
Authors: Paul Young, Diane Mackle, Rinaldo Bellomo, Michael Bailey, Richard Beasley, Adam Deane, Glenn Eastwood, Simon Finfer, Ross Freebairn, Victoria King, Natalie Linke, Edward Litton, Colin McArthur, Shay McGuinness, Rakshit Panwar, Tanya Baker, Sally Hurford, Mary La Pine, Diane Mackle, Carla McInnes, Leanlove Navarra, Allison Pritchard, Raulle Sol Cruz, Anne Turner, Tessa Broadley, Victoria King, Dana Lee, Natalie Linke, Liadain Reid, Lynnette Murray, Aimee Blakemore, Magdalena Butler, Keri-Anne Cowdrey, Eileen Gilder, Jane Hallion, Stephanie Long, Shay McGuinness, Philippa Neal, Rachael Parke, Samantha Wallace, Yan Chen, Colin McArthur, Rachael McConnochie, Lynette Newby, Catherine Simmonds, David Bowie, Brandon Burke, David Closey, Rosalind Crombie, Neil Davidson, Andrew Greer, Seton Henderson, Louise Hitchings, David Knight, Jan Mehrtens, Kate Miller, Emmeline Minto, Stacey Morgan, Anna Morris, Kim Parker, Jay Ritzema-Carter, Jessica Roberts, Christian Sahl, Geoffrey Shaw, Katherine Townend, Llesley Chadwick, Debra Chalmers, Ross Freebairn, Michael Park, Penelope Park, Christine Rolls, Carmel Chapman, Andrew Stapleton, Jefferson Aguila, Anisha Dias, Alex Kazemi, Vivian Lai, Rima Song, Tony Williams, Sheila Caniba, Maud Carpenter, Rica Dagooc, Danielle Hacking, Ywain Lawrey, Ulrike Buehner, Erin Williams, Jonathan Albrett, Carolyn Jackson, Peter Marko, Ben Barry, Nina Beehre, Dick Dinsdale, Samantha Edney, Frances Fitzjohn, Peter Hicks, Georgia Hill, Anna Hunt, Harriet Judd, Charlotte Latimer-Bell, Cassie Lawrence, Eden Lesona, Agnes McKay-Vucago, Leanlove Navarra, Chris Poynter, Alex Psirides, Yvonne Robertson, Hannah Smellie, Raulle Sol Cruz, Shawn Sturland, Bob Ure, Paul Young, Jasmin Board, Aidan Burrell, Tim Byrne, Eliza Dean, Emma Martin, Chris Mason, Phoebe McCracken, Sacha Richardson, Shirley Vallance, Meredith Young, Rinaldo Bellomo, Glenn Eastwood, Leah Peck, Helen Young, Ege Eroglu, Edward Litton ame>, Annemarie Palermo, Susan Pellicano, Shailesh Bihari, Xia Jin, Russell Laver, Elisha Matheson, Kate Schwartz, Tapaswi Shrestha, Timothy Beckingham, Natalie Soar, Dhiraj Bhatia, Lauren Bulfin, Timothy Crozier, Klaudija Lavrans, Julie Luong, Venkata Maduri, Michael Patterson, Chloe Peppin, Angela Wang, Catherine Kurenda, Sandra Peake, Nadeem Robaa, Patricia Williams, Lukasz Badek, Stanley Bart, Marianne Chapman, Michael Davies, Adam Deane, Sarah Doherty, Kathleen Glasby, Samuel Gluck, Robert Grieve, Palesh Karr, Joanne McIntyre, Stephanie O’Connor, Alexis Poole, Eamon Raith, Benjamin Reddi, Justine Rivett, Sandeep Sethi, Joannies Yap, Nikki Yeo, Yasmine Aliabdelhamind, James Anstey, Deborah Barge, Kathleen Byrne, Adam Deane, Sarah Doherty, Paul Emery, Peter Forrest, Madeline Haile, Sandra Lussier, Tom Rechnitzer, Geoffrey Wigmore, Annemarie Palermo, Susan Pellicano, Adrian Regli, Leanne Barbazza, Barry Dixon, Jennifer Holmes, John Santamaria, Roger Smith, Antony Tobin
Journal: Intensive Care Medicine (2020)
Nutritional domains in frailty tools: Working towards an operational definition of nutritional frailty
Authors: Roberta Zupo, Fabio Castellana, Ilaria Bortone, Chiara Griseta, Rodolfo Sardone, Luisa Lampignano, Madia Lozupone, Vincenzo Solfrizzi, Marco Castellana, Gianluigi Giannelli, Giovanni De Pergola, Heiner Boeing, Francesco Panza
Journal: Ageing Research Reviews (2020)
Bone marrow stromal fibroblasts secrete interleukin-6 and granulocyte- macrophage colony-stimulating factor in the absence of inflammatory stimulation: demonstration by serum-free bioassay, enzyme-linked immunosorbent assay, and reverse transcriptase polymerase chain reaction
Authors: SC Guba, CI Sartor, LR Gottschalk, YH Jing, T Mulligan, SG Emerson
Journal: Blood (1992)
Mass Testing for SARS-CoV-2 in 16 Prisons and Jails — Six Jurisdictions, United States, April–May 2020
Authors: Liesl M. Hagan, Samantha P. Williams, Anne C. Spaulding, Robin L. Toblin, Jessica Figlenski, Jeanne Ocampo, Tara Ross, Heidi Bauer, Justine Hutchinson, Kimberley D. Lucas, Matthew Zahn, Chun Chiang, Timothy Collins, Alexis Burakoff, Juli Bettridge, Ginger Stringer, Randolph Maul, Kristen Waters, Courtney Dewart, Jennifer Clayton, Sietske de Fijter, Radha Sadacharan, Linda Garcia, Naomi Lockett, Kirstin Short, Laxman Sunder, Senad Handanagic
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

Preventing coronavirus disease 2019 (COVID-19) in correctional and detention facilities* can be challenging because of population-dense housing, varied access to hygiene facilities and supplies, and limited space for isolation and quarantine (1). Incarcerated and detained populations have a high prevalence of chronic diseases, increasing their risk for severe COVID-19-associated illness and making early detection critical (2,3). Correctional and detention facilities are not closed systems; SARS-CoV-2, the virus that causes COVID-19, can be transmitted to and from the surrounding community through staff member and visitor movements as well as entry, transfer, and release of incarcerated and detained persons (1). To better understand SARS-CoV-2 prevalence in these settings, CDC requested data from 15 jurisdictions describing results of mass testing events among incarcerated and detained persons and cases identified through earlier symptom-based testing. Six jurisdictions reported SARS-CoV-2 prevalence of 0%-86.8% (median = 29.3%) from mass testing events in 16 adult facilities. Before mass testing, 15 of the 16 facilities had identified at least one COVID-19 case among incarcerated or detained persons using symptom-based testing, and mass testing increased the total number of known cases from 642 to 8,239. Case surveillance from symptom-based testing has likely underestimated SARS-CoV-2 prevalence in correctional and detention facilities. Broad-based testing can provide a more accurate assessment of prevalence and generate data to help control transmission (4).
Somatic Mutations Within the Untranslated Regions of Rearranged Ig Genes in a Case of Classical Hodgkin’s Disease as a Potential Cause for the Absence of Ig in the Lymphoma Cells
Authors: Andrea Jox, Thomas Zander, Ralf Küppers, Johannes Irsch, Holger Kanzler, Martin Kornacker, Heribert Bohlen, Volker Diehl, Jürgen Wolf
Journal: Blood (1999)
T cell receptor (alpha, beta, gamma) gene rearrangements and expression in normal and leukemic large granular lymphocytes/natural killer cells
Authors: PG Pelicci, P Allavena, M Subar, A Rambaldi, A Pirelli, M Di Bello, T Barbui, DM d Knowles, R Dalla-Favera, A Mantovani
Journal: Blood (1987)
Stool Microbiome Profiling of Patients with Metastatic Renal Cell Carcinoma Receiving Anti–PD-1 Immune Checkpoint Inhibitors
Authors: Nicholas J. Salgia, Paulo G. Bergerot, Manuel Caitano Maia, Nazli Dizman, JoAnn Hsu, John D. Gillece, Megan Folkerts, Lauren Reining, Jeffrey Trent, Sarah K. Highlander, Sumanta K. Pal
Journal: European Urology (2020)
Abstract 17420: Simvastatin Induces Cardiac Autophagy Through PTEN Activation
Authors: Pam Lee, Allen Andres, Chengqun Huang, Eric Ratliff, Roberta Gottlieb
Journal: Circulation (2011)

Background: Statins are a widely prescribed class of cholesterol-lowering drugs that inhibit HMG-CoA reductase, the rate-limiting step of cholesterol biosynthesis. Statins have been shown to be cardioprotective; however, the mechanism of this protection remains unclear. Autophagy is a housekeeping function that allows for the clearance of protein aggregates or dysfunctional organelles in order to maintain cellular homeostasis. We have shown that autophagy is required for cardioprotection. Recent studies have demonstrated that statins are able to induce autophagy. Therefore, we sought to explore the regulation of autophagy by statins in the heart. Methods: Simvastatin (Sigma) was diluted in DMSO, and added at 1μ M to C2C12 myotubes, or administered to FVB/N mice at doses ranging from 5 to 40 mg/kg via IP. Protein extracts from hearts and cells were prepared for western blot analysis. ROS production in cells was determined via FACS with H2-DCFDA. Results: Preliminary studies indicated that simvastatin induced autophagy in C2C12 cells, as assessed by increased conversion of LC3I to LC3II. Parallel studies in mice also showed a dose-dependent increase in LC3II/I ratio in hearts. We next investigated the effect of simvastatin upon the Akt/mTOR pathway, which suppresses autophagy. Concurrent with the increase in LC3II, simvastatin decreased Akt/mTOR activity, reflected by decreased phosphorylation of S6 and Akt. We observed an increase in PTEN, a well-recognized negative regulator of Akt. Moreover, we observed that cells treated with simvastatin produced less ROS, which are known to negatively regulate PTEN phosphatase activity. Mevalonate is a component of the cholesterol biosynthetic pathway downstream of HMG-CoA. Addition of mevalonate to statin-treated cells restored Akt and S6 activation to basal levels, thus indicating that cholesterol may mediate simvastatin's effects on Akt/mTOR. Conclusions: The robust induction of autophagy in heart after statin treatment is associated with decreased Akt/mTOR, as well as increased PTEN. Statin-induced autophagy may underlie the cardioprotective effects of statins.
Daratumumab, bortezomib, and dexamethasone in relapsed or refractory multiple myeloma: subgroup analysis of CASTOR based on cytogenetic risk
Authors: Katja Weisel, Andrew Spencer, Suzanne Lentzsch, Hervé Avet-Loiseau, Tomer M. Mark, Ivan Spicka, Tamas Masszi, Birgitta Lauri, Mark-David Levin, Alberto Bosi, Vania Hungria, Michele Cavo, Je-Jung Lee, Ajay Nooka, Hang Quach, Markus Munder, Cindy Lee, Wolney Barreto, Paolo Corradini, Chang-Ki Min, Asher A. Chanan-Khan, Noemi Horvath, Marcelo Capra, Meral Beksac, Roberto Ovilla, Jae-Cheol Jo, Ho-Jin Shin, Pieter Sonneveld, Tineke Casneuf, Nikki DeAngelis, Himal Amin, Jon Ukropec, Rachel Kobos, Maria-Victoria Mateos
Journal: Journal of Hematology & Oncology (2020)

Abstract Background Multiple myeloma (MM) patients with high cytogenetic risk have poor outcomes. In CASTOR, daratumumab plus bortezomib/dexamethasone (D-Vd) prolonged progression-free survival (PFS) versus bortezomib/dexamethasone (Vd) alone and exhibited tolerability in patients with relapsed or refractory MM (RRMM). Methods This subgroup analysis evaluated D-Vd versus Vd in CASTOR based on cytogenetic risk, determined using fluorescence in situ hybridization and/or karyotype testing performed locally. High-risk patients had t(4;14), t(14;16), and/or del17p abnormalities. Minimal residual disease (MRD; 10 −5 sensitivity threshold) was assessed via the clonoSEQ® assay V2.0. Of the 498 patients randomized, 40 (16%) in the D-Vd group and 35 (14%) in the Vd group were categorized as high risk. Results After a median follow-up of 40.0 months, D-Vd prolonged median PFS versus Vd in patients with standard (16.6 vs 6.6 months; HR, 0.26; 95% CI, 0.19-0.37; P &lt; 0.0001) and high (12.6 vs 6.2 months; HR, 0.41; 95% CI, 0.21–0.83; P = 0.0106) cytogenetic risk. D-Vd achieved deep responses, including higher rates of MRD negativity and sustained MRD negativity versus Vd, regardless of cytogenetic risk. The safety profile was consistent with the overall population of CASTOR. Conclusion These updated data reinforce the effectiveness and tolerability of daratumumab-based regimens for RRMM, regardless of cytogenetic risk status. Trial registration ClinicalTrials.gov, NCT02136134 . Registered 12 May 2014
EZH2-Mediated Downregulation of the Tumor Suppressor DAB2IP Maintains Ovarian Cancer Stem Cells
Authors: Xingyue Zong, Weini Wang, Ali Ozes, Fang Fang, George E. Sandusky, Kenneth P. Nephew
Journal: Cancer Research (2020)

The majority of women diagnosed with epithelial ovarian cancer eventually develop recurrence, which rapidly evolves into chemoresistant disease. Persistence of ovarian cancer stem cells (OCSC) at the end of therapy may be responsible for emergence of resistant tumors. In this study, we demonstrate that in OCSC, the tumor suppressor disabled homolog 2-interacting protein (DAB2IP) is silenced by EZH2-mediated H3K27 trimethylation of the DAB2IP promoter. CRISPR/Cas9-mediated deletion of DAB2IP in epithelial ovarian cancer cell lines upregulated expression of stemness-related genes and induced conversion of non-CSC to CSC, while enforced expression of DAB2IP suppressed CSC properties. Transcriptomic analysis showed that overexpression of DAB2IP in ovarian cancer significantly altered stemness-associated genes and bioinformatic analysis revealed WNT signaling as a dominant pathway mediating the CSC inhibitory effect of DAB2IP. Specifically, DAB2IP inhibited WNT signaling via downregulation of WNT5B, an important stemness inducer. Reverse phase protein array further demonstrated activation of noncanonical WNT signaling via C-JUN as a downstream target of WNT5B, which was blocked by inhibiting RAC1, a prominent regulator of C-JUN activation. Coadministration of EZH2 inhibitor GSK126 and RAC1 inhibitor NSC23766 suppressed OCSC survival in vitro and inhibited tumor growth and increased platinum sensitivity in vivo. Overall, these data establish that DAB2IP suppresses the cancer stem cell phenotype via inhibition of WNT5B-induced activation of C-JUN and can be epigenetically silenced by EZH2 in OCSC. Targeting the EZH2/DAB2IP/C-JUN axis therefore presents a promising strategy to prevent ovarian cancer recurrence and has potential for clinical translation. SIGNIFICANCE: These findings show that combining an epigenetic therapy with a noncanonical WNT signaling pathway inhibitor has the potential to eradicate ovarian cancer stem cells and to prevent ovarian cancer recurrence.
A Plan to Use Modern Data Tools to Fight Foodborne Illness
Authors: Mary Chris Jaklevic
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Integrated analysis of patient samples identifies biomarkers for venetoclax efficacy and combination strategies in acute myeloid leukemia
Authors: Haijiao Zhang, Yusuke Nakauchi, Thomas Köhnke, Melissa Stafford, Daniel Bottomly, Rozario Thomas, Beth Wilmot, Shannon K. McWeeney, Ravindra Majeti, Jeffrey W. Tyner
Journal: Nature Cancer (2020)
Thank you to our peer reviewers in 2019
Authors: Laura Hart
Journal: The Lancet Neurology (2020)

The COVID-19 pandemic has led to unprecedented challenges. In particular, the impact of COVID-19 on neurological services and patients has been immense, as highlighted in a recent Editorial.1The neurological impact of COVID-19.Lancet Neurol. 2020; 19: 471Summary Full Text Full Text PDF PubMed Scopus (23) Google Scholar Despite the heightened burden felt by neurologists, the dedication of our authors and reviewers is not waning. Submissions to The Lancet Neurology between Jan 1 and June 14, 2020, increased by around 70% compared with the same period last year. Unabated expert advice from our clinical and statistical reviewers from around the world is ensuring the continued publication of the highest quality research and reviews for our readers. The journal continues to strive towards the goal of the Lancet group of disseminating the best science for better lives. Our achievement is reflected by the continued placement of The Lancet Neurology as the leading clinical neurology journal, according to the 2019 Journal Citation Report. The names of everyone who reviewed papers for the journal throughout 2019 are listed in the appendix; those who reviewed five papers, or more, are marked with an asterisk. We extend our warmest gratitude to all these reviewers. Download .pdf (.13 MB) Help with pdf files Supplementary appendix