tbuckley/cabot-search huggingface dataset:
P095 Inflammatory bowel disease, during anti IL 17 treatment
Authors: R Hernández, A Perez Gil, J Uceda, JL Marenco de la Fuente
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Career situation of first and presenting author</h3> Student for a master or a PhD. <h3>Introduction</h3> IL 17-A blocking with Secukinumab (SEK) has proved efficacy in the treatment of psoriasis and psoriasic artritis (PsoAr). Inflammatory bowel disease (IBD) is more common among patients with psoriasis and is cosidered as a part of the spectrum of spondyloarthritis. IL-17 is a cytokine required for the normal homesotasis of the bowel and its inhibition could initiate a subclinic disease. <h3>Objectives</h3> We have observed 2 patients with IBD during therapy anti-IL17 for PsoAr. <h3>Results</h3> <b><i>Case 1</i></b> A 20-year-old woman with a diagnosis of plaque psoriasis since 12 years; she has been treated with topic treatment, phototherapy and Methotrexate. In November 2017 She presented skin worsening, (PASI 20, DLQI 20 and started treatment with SEK at a dose of 300 mg every 4 weeks. After the 2nd dose she began with abdominal pain and increased depositions. Acute phase reactants were increased major PCR 194 mg/dl ESR 87 mg/dl. In colonoscopy, biopsies objective and inflammatory lesions with extensive areas of mucosal ulceration compatible with Crohn's disease were observed. <b><i>Case 2</i></b> A 59-year-old man with a diagnosis of ankylosing spondylitis of 30 years of evolution without a clínical response to NSAIDs and sulphasalazine, was treated with SEK 150 mg. After the second dose during induction, He presented fever 38.9°C, abdominal pain, bloody diarrhea, and nocturnal tenesmo. A colonoscopy showed typical ulcerative colitis lesions with severe activity. <h3>Conclusions</h3> SEK is a very potent treatment for psoriasis and psoriatis arthitis, with positive results n Spondylitis, but not effective for IBD. Il-17 is a cytokine with a role in the normal intestinal homeostasis. Psoriasis and Spondyloarthritis patients have an association with IBD and uveítis. We present 2 patients who were diagnosed of IBD shortly after start SEK, anti-IL17. We think they could have a previous undiagnosed IBD; SEK could have trigger a flare but We can't rule out a role of IL-17 inhibition. During clinical trials for SEK, only 0.7 cases per 100 patients-year of IBD were reported. Caution must be taken before start SEK for patients to detect posible symptoms of IBD. <h3>Reference</h3> Schreiber S, Sands B, Deodhar A, <i>et al.</i> OP0113No Increased Incidence of Inflammatory Bowel Disease among Secukinumab-Treated Patients with Moderate To Severe Psoriasis, Psoriatic Arthritis, or Ankylosing Spondylitis: Data from 14 Phase 2 and Phase 3 Clinical Studies. <i>Annals of the Rheumatic Diseases</i> 2016;75(Suppl 2):97–98. <h3>Disclosure of Interest</h3> None declared.
Abstract 10655: Energy Drink Induced Impairment of Arterial Endothelial Function in Healthy Young Adults
Authors: John P Higgins, Robin Jacob, Farzan Husain, Ioannis N Liras, George N Liras, Brandon L Ortiz, Karan Bhatti, Benjamin Yang, George T Le
Journal: Circulation (2018)

Introduction: Consumption of energy drinks have been associated with adverse events on the cardiovascular, neurological, gastrointestinal, renal, endocrine, and psychiatric systems, especially in t...
P044 Effect of specialized 6-month ADL training with subsequent a 6-month follow-up period in patients with myositis – preliminary data
Authors: M Spiritovic, S Oreska, H Storkanova, B Hermankova, P Cesak, A Rathouska, K Kubinova, M Klein, L Vernerova, O Ruzickova, H Mann, K Pavelka, L Senolt, J Vencovsky, M Tomcik
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Career situation of first and presenting author</h3> Student for a master or a PhD. <h3>Introduction</h3> Idiopathic inflammatory myopathies (IIM) are accompanied by muscular weakness caused by inflammation and immune changes in affected muscles, resulting in reduced quality of life. The aim of our study was to determine the effect of ADL training on muscle strength and endurance and quality of life of IIM patients. <h3>Objectives</h3> The study included a total of 50 IIM patients who fulfilled the Bohan and Peter 1975 criteria and had skeletal muscle involvement. 27 patients were recruited into the intervention group (IG) and 23 patients into the control group (CG). Both groups received an educational material for home exercise, but only the IG underwent a 6 month intervention with a subsequent 6 month follow-up period. <h3>Methods</h3> Patients were assessed by a physician and a physiotherapist blinded to intervention at months 0, 3, 6, and 12, and parameters evaluating quality of life, muscle strength and endurance were recorded. Patients also filled out PRO (patient reported outcomes) questionnaires and provided blood for routine laboratory analysis and bio-banking. Data analysis was performed between groups and within the group. <h3>Results</h3> Compared to the observed statistically significant deterioration in the CG over the intervention period of 0–6 months, we found a statistically significant improvement in the IG in objectively assessed strength and endurance of muscles as well as in subjectively assessed functional abilities and depression. During the follow-up period, there was a significant deterioration or stagnation of the achieved positive results in the IG. However, improved functional ability during the intervention period persisted in the IG in the follow-up period as well. Only numerical improvements in the IG during the intervention compared to the numerical deterioration in CG, that did not reach statistical significance, were observed in some subjectively assessed domains of QoL (SF-36) and fatigue (FIS – in physical dimension). <h3>Conclusions</h3> Our specialized ADL training led to a significant improvement in the observed parameters that was clinically significant in a substantial proportion of patients, and prevention of the expected worsening of muscle weakness and quality of life. <h3>Acknowledgements</h3> Supported by AZV-16-33574A, SVV for FTVS UK 2019-260466, MHCR 023728. <h3>Disclosure of Interest</h3> None declared.
Information for Readers&lt;subtitle&gt;The JAMA 1996 Editorial Peer Review Audit&lt;/subtitle&gt;
Authors: Elaine S. Williams
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Safety of D-Dimer As a Stand-Alone Test for the Exclusion of Deep Vein Thrombosis Compared to Other Strategies
Authors: Synne Fronas, Hilde Skuterud Wik, Anders EA Dahm, Camilla Tøvik Jørgensen, Jostein Gleditsch, Nezar Raouf, Erik A Klok, Waleed Ghanima
Journal: Blood (2018)
Transcriptional Downregulation of miR-4306 serves as a New Therapeutic Target for Triple Negative Breast Cancer
Authors: Zitong Zhao, Lin Li, Peina Du, Liying Ma, Weimin Zhang, Leilei Zheng, Bo Lan, Bailin Zhang, Fei Ma, Bo Xu, Qimin Zhan, Yongmei Song
Journal: Theranostics (2019)

Rationale: Triple-negative breast cancer (TNBC) is characterized by the absence of estrogen receptor alpha (ER-α), human epidermal growth factor receptor 2 (HER2) and progesterone receptor (PR) expression, but the effect of lacking the three factors on TNBC is unclear. Whether loss of the three factors contributes to deregulate genes that participate in the progress of TNBC remains unknown. Methods: We performed microRNA arrays and comprehensive analysis to screen for miRNAs that are transcriptionally regulated by ER-α, HER2 and PR. Functional assays and molecular mechanism studies were used to investigate the role of miR-4306 in TNBC. An orthotopic mouse model of TNBC was used to evaluate the therapeutic potential of a cholesterol-conjugated miR-4306 mimic. Results: We found that miR-4306 is transcriptionally regulated by ER-α, HER2 and PR, and the downregulation of miR-4306 in TNBC is caused by the loss of ER-α, HER2 and PR. Clinically, low miR-4306 expression is strongly associated with lymph node metastasis and poor survival for TNBC. Upregulation of miR-4306 greatly suppresses TNBC cell proliferation, migration and invasion and abrogates angiogenesis and lymphangiogenesis in vitro. According to in vivo models, miR-4306 overexpression considerably inhibits TNBC growth, lung metastasis, angiogenesis and lymph node metastasis. Mechanistic analyses indicate that miR-4306 directly targets SIX1/Cdc42/VEGFA to inactivate the signaling pathways mediated by SIX1/Cdc42/VEGFA. Finally, the orthotopic mouse model of TNBC reveals that miR-4306 mimic can be used for TNBC treatment in combination with cisplatin. Conclusions: Our findings suggest that miR-4306 acts as a tumor suppressor in TNBC and is a potential therapeutic target for TNBC treatment.
Fund practices directly rather than putting money into national initiatives, say GPs
Authors: Abi Rimmer
Journal: BMJ (2019)

GPs believe that an increase in funding for general practice would most improve primary care, a survey has found.

Researchers from Warwick Medical school surveyed 1697 GPs in the Wessex region of England in late 2017 and received 929 responses (54.7% response rate).1

Of those that responded, almost a third (225, 27.9%) said that increased funding would have the most positive impact on general practice, followed by more GPs (184, 22.8%), and better education of the public (107, 13.3%).

The survey, which was published in BMJ Open , also asked for views of the national initiatives that are aimed at tackling workforce problems in primary care. The researchers found that respondents felt positive about many initiatives, such as those that invested in practice …
ECG Response: December 1, 2015
Authors: Philip Podrid
Journal: Circulation (2015)

ECG Challenge Response 2162ECG Challenge: A 26-year-old man without any known heart disease reports intermittent palpitations that last for several minutes and he thinks terminate with coughing.He has been seen several times in an emergency department, but no etiology for the palpitations has been established.His baseline ECG is seen (ECG A).He has an episode of palpitations that lasts several hours that prompts another visit to the emergency department.An ECG during the palpitations is recorded (ECG B).
Characterization of Exceptional Responders to Autologous Stem Cell Transplantation in Multiple Myeloma
Authors: Ashley Paquin, Morie A. Gertz, Hafsa Chaudhry, Shaji K. Kumar, Francis K. Buadi, Angela Dispenzieri, David Dingli, Yi Hwa, Amie Fonder, Miriam Hobbs, Suzanne R. Hayman, Steven Zeldenrust, John A. Lust, Stephen J. Russell, Nelson Leung, Prashant Kapoor, Ronald S. Go, Yi Lin, Wilson I Gonsalves, Taxiarchis Kourelis, Rahma Warsame, Robert A. Kyle, S. Vincent Rajkumar
Journal: Blood (2018)
Interim PET-Based Outcome Prediction in Diffuse Large B-Cell Lymphoma Patients Participating in the Positron Emission Tomography-Guided Therapy of Aggressive Non-Hodgkin Lymphomas (PETAL) Trial: Comparison of the Delta SUV Max Method and the Deauville 5-Point Scale
Authors: Jan Rekowski, Andreas Hüttmann, Christine Schmitz, Stefan P. Müller, Karl-Heinz Jöckel, Ulrich Duehrsen
Journal: Blood (2018)
Low Dose Anti-Thymocyte Globulin Plus Low Dose Post-Transplant Cyclophosphamide As Graft-Versus-Host Disease Prophylaxis in Haploidentical Peripheral Blood Stem Cell Transplantation for Patients with Hematologic Malignancies: A Prospective, Phase II Study
Authors: Jun Yang, Jiang Jieling, Yu CAI, Su Li, Liping Wan, Jun Zhu, Huixia Liu, Shan Shao, Haitao Bai, Chun Wang, Jiong Hu, Xianmin Song
Journal: Blood (2018)
ECG Response: January 27, 2015
Authors: Philip Podrid
Journal: Circulation (2015)

a history of hypertension associated with left ventricular hypertrophy and also coronary artery disease.He has not undergone any previous intervention but has chronic stable angina.He presents to his cardiologist for a routine follow-up.He has no complaints.His physical examination is normal.As part of his visit an ECG is obtained.
P021 Differential ACPA binding to nuclear antigens reveals a distinct subset of acetylation cross-reactive autoantibodies in rheumatoid arthritis
Authors: G Wigerblad, KA Lloyd, P Sahlström, E Ossipova, K Chemin, J Steen, PJ Titcombe, D Zhou, R Stålesen, J Rönnelid, DL Mueller, MJ Kaplan, K Skriner, L Klareskog, F Wermeling, V Malmström, C Grönwall
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Career situation of first and presenting author</h3> Young investigator. <h3>Introduction</h3> Anti-citrullinated protein autoantibodies (ACPA) in RA patients target a wide range of modified proteins and recent findings reveal that monoclonal ACPA are cross-reactive due to recognition of shared consensus citrulline-peptide motifs. Among physiological targets of ACPA, citrullination in neutrophil extracellular trap (NET) products, have been postulated to be important. <h3>Objectives</h3> We sought to characterize the anti-nuclear and anti-neutrophil reactivities of different patient-derived monoclonal ACPA. <h3>Methods</h3> The study included ten recombinant single B-cell derived RA monoclonal ACPA-IgG with CCP2 reactivity from different cell subsets and compartments (1, 2). They were screened for HEp-2 ANA reactivity, and binding to apoptotic cells or stimulated neutrophils. Binding was compared to CRISPR PAD4 KO cells and neutrophils from PAD2 and PAD4 KO mice. Immunoprecipitation and mass spectrometry were used to identify modified nuclear ACPA targets, and ELISA and Western blot for mAb binding to acetylated epitopes. <h3>Results</h3> Four out of ten ACPA clones exhibited strong binding to apoptotic cells, nuclear binding to activated neutrophils, and reactivity to NETs. Three of these were ANA positive. Another NET-reactive ACPA instead displayed a cytoplasmic binding pattern. This cytoplasmic NET-binding was PAD4-dependent, whilst nuclear-mediated NET reactivity was PAD-independent. Using apoptotic cells, acetylated histones were confirmed to be the primary targets of the nuclear reactivity, which could be explained by consensus-motif driven ACPA cross-reactivity. Specifically targeted acetylated histone peptides were identified and the anti-modified protein autoantibody (AMPA) profiles of the ACPA were found to correlate with cell binding. <h3>Conclusions</h3> When investigating monoclonal ACPA, our novel data reveal a distinct subset of ACPA with nuclear binding patterns and AMPA activity with acetylated histones (and not citrullinated proteins) in NETs and apoptotic cells. <h3>References</h3> Titcombe PJ, Wigerblade G, Sippl N, Zhang N, Shmagel AK, <i>et al.</i> Pathogenic citrulline-multispecific B cell receptor clades in rheumatoid arthritis. <i>Arthritis Rheumatol</i> 2018. doi:10.1002/art.40590 Steen J, Forsström B, Sahlström P, Odowd V, Israelsson L, <i>et al.</i> Human plasma cell derived monoclonal antibodies to posttranslationally modified proteins recognize amino acid motifs rather than specific proteins. <i>Arthritis Rheumatol</i> 2018. doi:10.1002/art.40699 <h3>Disclosure of Interest</h3> None declared.
Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia
Authors: Eric Wang, Sydney X. Lu, Alessandro Pastore, Xufeng Chen, Jochen Imig, Stanley Chun-Wei Lee, Kathryn Hockemeyer, Yohana E. Ghebrechristos, Akihide Yoshimi, Daichi Inoue, Michelle Ki, Hana Cho, Lillian Bitner, Andreas Kloetgen, Kuan-Ting Lin, Taisuke Uehara, Takashi Owa, Raoul Tibes, Adrian R. Krainer, Omar Abdel-Wahab, Iannis Aifantis
Journal: Cancer Cell (2019)
Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca <sup>2+</sup> -ATPase in Heart Failure
Authors: Przemek A. Gorski, Seung Pil Jang, Dongtak Jeong, Ahyoung Lee, Philyoung Lee, Jae Gyun Oh, Vadim Chepurko, Dong Kwon Yang, Tae Hwan Kwak, Soo Hyun Eom, Zee-Yong Park, Yung Joon Yoo, Do Han Kim, Hyun Kook, Yoichi Sunagawa, Tatsuya Morimoto, Koji Hasegawa, Junichi Sadoshima, Peter Vangheluwe, Roger J. Hajjar, Woo Jin Park, Changwon Kho
Journal: Circulation Research (2019)

Rationale: SERCA2a, sarco-endoplasmic reticulum Ca 2+ -ATPase, is a critical determinant of cardiac function. Reduced level and activity of SERCA2a are major features of heart failure. Accordingly, intensive efforts have been made to develop efficient modalities for SERCA2a activation. We showed that the activity of SERCA2a is enhanced by post-translational modification with SUMO1 (small ubiquitin-like modifier 1). However, the roles of other post-translational modifications on SERCA2a are still unknown. Objective: In this study, we aim to assess the role of lysine acetylation on SERCA2a function and determine whether inhibition of lysine acetylation can improve cardiac function in the setting of heart failure. Methods and Results: The acetylation of SERCA2a was significantly increased in failing hearts of humans, mice, and pigs, which is associated with the reduced level of SIRT1 (sirtuin 1), a class III histone deacetylase. Downregulation of SIRT1 increased the SERCA2a acetylation, which in turn led to SERCA2a dysfunction and cardiac defects at baseline. In contrast, pharmacological activation of SIRT1 reduced the SERCA2a acetylation, which was accompanied by recovery of SERCA2a function and cardiac defects in failing hearts. Lysine 492 (K492) was of critical importance for the regulation of SERCA2a activity via acetylation. Acetylation at K492 significantly reduced the SERCA2a activity, presumably through interfering with the binding of ATP to SERCA2a. In failing hearts, acetylation at K492 appeared to be mediated by p300 (histone acetyltransferase p300), a histone acetyltransferase. Conclusions: These results indicate that acetylation/deacetylation at K492, which is regulated by SIRT1 and p300, is critical for the regulation of SERCA2a activity in hearts. Pharmacological activation of SIRT1 can restore SERCA2a activity through deacetylation at K492. These findings might provide a novel strategy for the treatment of heart failure.
P173 Complex assessment of bone mineral density, fracture risk, vitamin D status and bone metabolism in hungarian systemic sclerosis patients
Authors: Z Szekanecz, Á Horváth, E Végh, A Pusztai, Z Pethö, A Hamar, HP Bhattoa, G Nagy, B Juhász, K Hodosi, A Domján, G Szücs, S Szamosi
Journal: Annals of the Rheumatic Diseases (2019)

<h3>Career situation of first and presenting author</h3> Instructor. <h3>Introduction</h3> Osteoporosis has been associated with systemic sclerosis (SSc). <h3>Objectives</h3> We wished to determine bone alterations in SSc patients by conventional densitometry (DXA), peripheral quantitative computed tomography (pQCT) and bone biomarkers. <h3>Methods</h3> We included 44 SSc patients and 33 age-matched healthy controls. Lumbar spine and femoral neck bone mineral density (BMD) was assessed by DXA. Volumetric BMD was measured by pQCT at the radius. FRAX, 25-hydroxyvitamin-D<sub>3</sub> (25-OH-D<sub>3</sub>), parathyroid hormone, osteocalcin, C-terminal collagen telopeptide and procollagen type I amino-terminal propeptide were also assessed. <h3>Results</h3> SSc patients had lower L2–4 BMD (0.880±0.108 vs. 0.996±0.181 g/cm<sup>2</sup>; p=0.019) and femoral neck (FN) BMD (0.786±0.134 vs. 0.910±0.090 g/cm<sup>2</sup>; p=0.007) by DXA. In SSc vs controls, pQCT indicated lower mean cortical (328.03±103.32 vs 487.06±42.45 mg/cm<sup>3</sup>; p&lt;0.001) and trabecular density (150.93±61.91 vs 184.76±33.03 mg/cm<sup>3</sup>; p=0.037). Vitamin D<sub>3</sub> deficiency was more common in SSc vs controls (60.0% vs 39.3%; p=0.003). L2–4 (p=0.002) and FN BMD (p=0.015) positively correlated with BMI. pQCT assessments confirmed an inverse correlation between pulmonary manifestation and total (p=0.024), trabecular (p=0.035) and cortical density (p=0.015). Anti-Scl70 positivity inversely correlated with pQCT total density (p=0.015) and the presence of digital ulcers with cortical density (p=0.001). We also found that vertebral and FN BMD as determined by DXA significantly correlated with pQCT total, trabecular and cortical density (p&lt;0.05). <h3>Conclusions</h3> The results of our study suggest that bone loss in SSc patients may be associated with lower BMI, anti Scl70 positivity, and the presence of pulmonary manifestations and digital ulcers. Both DXA and pQCT are appropriate tools to evaluate the bone alterations in SSc patients. <h3>Acknowledgements</h3> This research was supported by Hungarian National Scientific Research Fund (OTKA) grant No. K 105073 (H.P.B. and Z.S.); by the European Union and the State of Hungary and co-financed by the European Social Fund in the framework of TAMOP-4.2.4.A/2-11/1-2012-0001 'National Excellence Program '(Z.S.); by the European Union grants GINOP-2.3.2-15-2016-00015 and GINOP-2.3.2-15-2016-00050 (Z.S.). <h3>Disclosure of Interest</h3> None declared.
Burden, access, and disparities in kidney disease
Authors: Deidra C. Crews, Aminu K. Bello, Gamal Saadi, Philip Kam Tao Li, Guillermo Garcia-Garcia, Sharon Andreoli, Deidra Crews, Kamyar Kalantar-Zadeh, Charles Kernahan, Latha Kumaraswami, Gamal Saadi, Luisa Strani
Journal: Kidney International (2019)
Updated Results from a Phase 1 Study of Gilteritinib in Combination with Induction and Consolidation Chemotherapy in Subjects with Newly Diagnosed Acute Myeloid Leukemia (AML)
Authors: Keith W. Pratz, Mohamad Cherry, Jessica K. Altman, Brenda Cooper, Jose Carlos Cruz, Joseph G. Jurcic, Mark J. Levis, Tara L Lin, Alexander E. Perl, Nikolai A. Podoltsev, Gary J. Schiller, Chaofeng Liu, Erkut Bahceci
Journal: Blood (2018)
Safety and Efficacy of Long Term Suppression of PI3Kinase Pathway By Small Molecule PI3K-Delta Inhibitor, Leniolisib in Apds (Activated PI3Kδ Syndrome)
Authors: V. Koneti Rao, Sharon Webster, Virgil A.S.H. Dalm, Anna Sediva, P. Martin van Hagen, H. Michael Do, Les Folio, Maciej Cabanski, Marie-Anne Valentin, Stefan de Buck, Christoph Kalis, Anke Hasselberg, Christoph Burkhart, Klaus Kucher, Birgitte Sloth, Gulbu Uzel
Journal: Blood (2018)
Characteristics and Outcome of HIV-Associated Primary Effusion Lymphoma (PEL) As Observed in the German HIV-Related Lymphoma Cohort Study
Authors: Marcus Hentrich, Philipp Schommers, Markus Mülller, Christoph Wyen, Henrike Thomssen, Timo Wolf, Jan-Christian Wasmuth, Johannes Bogner, Christian Hoffmann
Journal: Blood (2018)