tbuckley/cabot-search huggingface dataset:
Catch and Release: Mutant YAP as a Molecular Driver of Tumor Cell Dissemination
Authors: Shawn M. Davidson
Journal: Cancer Research (2020)

Abstract The study by Benjamin and colleagues demonstrates that mutant YAP expression is sufficient to enhance tumor cell dissemination in zebrafish and mice. Moreover, the integration of approaches in biology and engineering taken here provides an important framework to link physical, physiological, and molecular properties of disseminated tumor cells (DTC). Similar integrated approaches will pave the way for future studies to generate global cancer cell dissemination maps and provide further insight into the prognostic value of DTCs for metastatic organotropisms. See related article by Benjamin et al., p. 3867
Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface
Authors: Frederick B. Shipley, Neil Dani, Huixin Xu, Christopher Deister, Jin Cui, Joshua P. Head, Cameron Sadegh, Ryann M. Fame, Morgan L. Shannon, Vanessa I. Flores, Thomas Kishkovich, Emily Jang, Eric M. Klein, Glenn J. Goldey, Kangmin He, Yong Zhang, Michael J. Holtzman, Tomas Kirchhausen, Claire Wyart, Christopher I. Moore, Mark L. Andermann, Maria K. Lehtinen
Journal: Neuron (2020)
IDH1/2 mutations in acute myeloid leukemia patients and risk of coronary artery disease and cardiac dysfunction—a retrospective propensity score analysis
Authors: Badder Kattih, Amir Shirvani, Piroska Klement, Abel Martin Garrido, Razif Gabdoulline, Alessandro Liebich, Maximilian Brandes, Anuhar Chaturvedi, Timon Seeger, Felicitas Thol, Gudrun Göhring, Brigitte Schlegelberger, Robert Geffers, David John, Udo Bavendiek, Johann Bauersachs, Arnold Ganser, Joerg Heineke, Michael Heuser
Journal: Leukemia (2020)

Abstract Clonal hematopoiesis of indeterminate potential (CHIP) is linked to leukemia gene mutations and associates with an increased risk for coronary artery disease and poor prognosis in ischemic cardiomyopathy. Two recurrently mutated genes in CHIP and adult acute myeloid leukemia (AML) encode for isocitrate dehydrogenases 1 and 2 ( IDH1 and IDH2 ). Global expression of mutant IDH2 in transgenic mice-induced dilated cardiomyopathy and muscular dystrophy. In this retrospective observational study, we investigated whether mutant IDH1/2 predisposes to cardiovascular disease in AML patients. Among 363 AML patients, IDH1 and IDH2 mutations were detected in 26 (7.2%) and 39 patients (10.7%), respectively. Mutant IDH1 patients exhibited a significantly higher prevalence of coronary artery disease (26.1% vs. 6.4%, p = 0.002). Applying inverse probability-weighting analysis, patients with IDH1/2 mutations had a higher risk for a declining cardiac function during AML treatment compared to IDH1/2 wild type patients [left ventricular ejection fraction pretreatment compared to 10 months after diagnosis: 59.2% to 41.9% ( p &lt; 0.001) vs 58.5% to 55.4% ( p = 0.27), respectively]. Mechanistically, RNA sequencing and immunostaining in hiPS-derived cardiomyocytes indicated that the oncometabolite R-2HG exacerbated doxorubicin mediated cardiotoxicity. Evaluation of IDH1/2 mutation status may therefore help identifying AML patients at risk for cardiovascular complications during cytotoxic treatment.
Modelling kidney disease using ontology: insights from the Kidney Precision Medicine Project
Authors: Edison Ong, Lucy L. Wang, Jennifer Schaub, John F. O’Toole, Becky Steck, Avi Z. Rosenberg, Frederick Dowd, Jens Hansen, Laura Barisoni, Sanjay Jain, Ian H. de Boer, M. Todd Valerius, Sushrut S. Waikar, Christopher Park, Dana C. Crawford, Theodore Alexandrov, Christopher R. Anderton, Christian Stoeckert, Chunhua Weng, Alexander D. Diehl, Christopher J. Mungall, Melissa Haendel, Peter N. Robinson, Jonathan Himmelfarb, Ravi Iyengar, Matthias Kretzler, Sean Mooney, Yongqun He
Journal: Nature Reviews Nephrology (2020)
Mitral Regurgitation After Percutaneous Mitral Valvuloplasty
Authors: Maria Carmo P. Nunes, Robert A. Levine, Renato Braulio, Marcelo A. Pascoal-Xavier, Sammy Elmariah, Nayana F.A. Gomes, Juliana R. Soares, William A.M. Esteves, Xin Zeng, Jacob P. Dal-Bianco, Livia S.A. Passos, Luiz G. Passaglia, Victor T. Ribeiro, Cláudio L. Gelape, Paulo H.N. Costa, Lucas Lodi-Junqueira, Walderez Dutra, Timothy C. Tan, Elena Aikawa, Judy Hung
Journal: JACC. Cardiovascular imaging (2020)
Confocal LASER endomicroscopy in Niemann–Pick disease type B
Authors: Thomas Villeneuve, Nicolas Guibert, Samia Collot, Pierre Fajadet, Magali Colombat, Monique Courtade-Saïdi, Thierry Levade, Alain Didier, Grégoire Prévot
Journal: European Respiratory Journal (2020)

<b>This study presents the very first pCLE images of Niemann–Pick type B disease. This minimally invasive approach, at the crossroads between imaging and histology, may represent a valuable tool in the differential diagnosis of ILDs, including NPB.</b>https://bit.ly/2D5Bfju
Looking Back to Find the Missing P Wave and Diagnose a Narrow Complex Tachycardia
Authors: John M. Cunningham, Ryan Borne
Journal: JAMA Internal Medicine (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Inactivation of ApoC3 by CRISPR/Cas9 Protects Against Atherosclerosis in Hamsters
Authors: Mengmeng Guo, Yitong Xu, Zhao Dong, Zihao Zhou, Nathan Cong, Mingming Gao, Wei Huang, Yuhui Wang, George Liu, Xunde Xian
Journal: Circulation Research (2020)
Author Correction: Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling
Authors: Chuanhui Han, Zhida Liu, Yunjia Zhang, Aijun Shen, Chunbo Dong, Anli Zhang, Casey Moore, Zhenhua Ren, Changzheng Lu, Xuezhi Cao, Chun-Li Zhang, Jian Qiao, Yang-Xin Fu
Journal: Nature Immunology (2020)
Visceral Metastases as Predictors of Response and Survival Outcomes in Patients of Castration-Resistant Prostate Cancer Treated With 177Lu-Labeled Prostate-Specific Membrane Antigen Radioligand Therapy
Authors: Swayamjeet Satapathy, Bhagwant Rai Mittal, Ashwani Sood
Journal: Clinical Nuclear Medicine (2020)

The presence of visceral metastases is associated with poor prognosis in patients of metastatic castration-resistant prostate cancer (mCRPC) treated with hormonal therapy and chemotherapy. However, studies evaluating its impact on treatment outcomes with Lu-labeled prostate-specific membrane antigen (PSMA) radioligand therapy (RLT) are currently limited and show inconsistent results. This systematic review was conducted to precisely evaluate the impact of visceral metastases on biochemical response and survival outcomes in patients of mCRPC treated with Lu-PSMA RLT.This systematic review followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guidelines. Searches in PubMed, Scopus, and EMBASE were made using relevant keywords, and articles up to May 2020 were included. Univariate and multivariate odds ratios and hazard ratios (HRs) were extracted from the individual articles, and pooled estimates were generated using meta-analysis.Twelve articles comprising 1504 patients were included in this review. Presence of visceral metastases not only predicted low biochemical response rate (pooled univariate odds ratio: 0.38, 95% confidence interval [CI], 0.22-0.66) but was also a significant prognosticator of worse progression-free survival (pooled univariate HR, 1.85; 95% CI, 1.39-2.46; and pooled multivariate HR, 1.48; 95% CI, 1.15-1.92) and overall survival (pooled univariate HR, 1.77; 95% CI, 1.29-2.44; and pooled multivariate HR, 2.22; 95% CI, 1.82-2.70). There was no evidence of publication bias.Presence of visceral metastases was associated with poor response and survival outcomes in patients of mCRPC treated with Lu-PSMA RLT. The results are clinically significant for pretreatment risk stratification of such patients and to guide optimal treatment strategies.
Ankylosing Spondylitis With Bilateral Symmetrical Uptake in the Greater Trochanters on Bone Scan
Authors: Wael M. Marashdeh, Hussein S. Alsa’di, Kusai M. Al-Muqbel, Ma’moon Al-Omari, Khalid Abdalla
Journal: Clinical Nuclear Medicine (2020)

Abstract Ankylosing spondylitis is a chronic inflammatory bone disease that commonly affects the spine and the sacroiliac joints. Ankylosing spondylitis can also cause enthesitis, or enthesopathy, which is an inflammation at the tendinous or ligamentous insertion sites on the bones. In this study, we present the case of a 37-year-old man with ankylosing spondylitis with a unique 99m Tc-HDP bone scan finding of symmetrical increased uptake bilaterally in the greater trochanters.
Heat shock factor 1 (HSF1-pSer326) predicts response to bortezomib-containing chemotherapy in pediatric AML: a COG report
Authors: Fieke W. Hoff, Anneke D. van Dijk, Yihua Qiu, Peter P. Ruvolo, Robert B. Gerbing, Amanda R. Leonti, Gaye N. Jenkins, Alan S. Gamis, Richard Aplenc, E. Anders Kolb, Todd A. Alonzo, Soheil Meshinchi, Eveline S. J. M. de Bont, Sophia W. M. Bruggeman, Steven M. Kornblau, Terzah M. Horton
Journal: Blood (2020)
Progressive fibrosing interstitial lung disease: a clinical cohort (the PROGRESS study)
Authors: Mouhamad Nasser, Sophie Larrieu, Salim Si-Mohamed, Kaïs Ahmad, Loic Boussel, Marie Brevet, Lara Chalabreysse, Céline Fabre, Sébastien Marque, Didier Revel, Françoise Thivolet-Bejui, Julie Traclet, Sabrina Zeghmar, Delphine Maucort-Boulch, Vincent Cottin
Journal: European Respiratory Journal (2020)

In patients with chronic fibrosing interstitial lung disease (ILD), a progressive fibrosing phenotype (PF-ILD) may develop, but information on the frequency and characteristics of this population outside clinical trials is lacking. We assessed the characteristics and outcomes of patients with PF-ILD other than idiopathic pulmonary fibrosis (IPF) in a real-world, single-centre clinical cohort. The files of all consecutive adult patients with fibrosing ILD (2010–2017) were examined retrospectively for pre-defined criteria of ≥10% fibrosis on high-resolution computed tomography and progressive disease during overlapping windows of 2 years. Baseline was defined as the date disease progression was identified. Patients receiving nintedanib or pirfenidone were censored from survival and progression analyses. In total, 1395 patients were screened; 617 had ILD other than IPF or combined pulmonary fibrosis and emphysema, and 168 had progressive fibrosing phenotypes. In 165 evaluable patients, median age was 61 years; 57% were female. Baseline mean forced vital capacity (FVC) was 74±22% predicted. Median duration of follow-up was 46.2 months. Annualised FVC decline during the first year was estimated at 136±328 mL using a linear mixed model. Overall survival was 83% at 3 years and 72% at 5 years. Using multivariate Cox regression analysis, mortality was significantly associated with relative FVC decline ≥10% in the previous 24 months (p&lt;0.05), age ≥50 years (p&lt;0.01) and diagnosis subgroup (p&lt;0.01). In this cohort of patients with PF-ILD not receiving antifibrotic therapy, the disease followed a course characterised by continued decline in lung function, which predicted mortality.
Tricuspid regurgitant jet velocity and myocardial tissue Doppler parameters predict mortality in a cohort of patients with sickle cell disease spanning from pediatric to adult age groups ‐ revisiting this controversial concept after 16 years of additional evidence
Authors: Payal Shah, Silvie Suriany, Roberta Kato, Adam M. Bush, Patjanaporn Chalacheva, Saranya Veluswamy, Christopher C. Denton, Kelly Russell, Maha Khaleel, Henry J. Forman, Michael C. K. Khoo, Richard Sposto, Thomas D. Coates, John C. Wood, Jon Detterich
Journal: American Journal of Hematology (2020)

Sickle cell disease (SCD) is a monogenic hemoglobinopathy associated with significant morbidity and mortality. Cardiopulmonary, vascular and sudden death are the reasons for the majority of young adult mortality in SCD. To better understand the clinical importance of multi-level vascular dysfunction, in 2009 we assessed cardiac function including tricuspid regurgitant jet velocity (TRV), tissue velocity in systole(S') and diastole (E'), inflammatory, rheologic and hemolytic biomarkers as predictors of mortality in patients with SCD. With up to 9 years of follow up, we determined survival in 95 children, adolescents and adults with SCD. Thirty-eight patients (40%) were less than 21 years old at initial evaluation. Survival and Cox proportional-hazards analysis were performed. There was 19% mortality in our cohort, with median age at death of 35 years. In the pediatric subset, there was 11% mortality during the follow up period. The causes of death included cardiovascular and pulmonary complications in addition to other end-organ failure. On Cox proportional-hazards analysis, our model predicts that a 0.1 m/s increase in TRV increases risk of mortality 3%, 1 cm/s increase in S' results in a 91% increase, and 1 cm/s decrease in E' results in a 43% increase in mortality. While excluding cardiac parameters, higher plasma free hemoglobin was significantly associated with risk of mortality (p=.049). In conclusion, elevated TRV and altered markers of cardiac systolic and diastolic function predict mortality in a cohort of adolescents and young adult patients with SCD. These predictors should be considered when counseling cardiovascular risk and therapeutic optimization at transition to adult providers.
Solitary Acute Inflammatory Demyelinating Lesion of the Cervical Spinal Cord Mimicking Malignancy on FDG PET/CT
Authors: Qianyun Liu, Mingyuan Liu, Yushu Bai, Aisheng Dong
Journal: Clinical Nuclear Medicine (2020)

Abstract A 43-year-old woman presented with numbness of the left hand and leg for 4 weeks. MRI of the spinal cord revealed an intramedullary lesion with central nodular enhancement at the C3 level. Primary tumor or metastasis of the cervical spinal cord was suspected. FDG PET/CT showed focal hypermetabolism of the spinal cord corresponding to the gadolinium-enhanced nodule. The patient underwent resection of the cervical spinal cord lesion. Histopathological findings of the resected specimens were consistent with acute inflammatory demyelinating lesion.
Upper respiratory viral load in asymptomatic individuals and mildly symptomatic patients with SARS-CoV-2 infection
Authors: Sang Hyun Ra, Joon Seo Lim, Gwang-un Kim, Min Jae Kim, Jiwon Jung, Sung-Han Kim
Journal: Thorax (2020)

Asymptomatic individuals with SARS-CoV-2 infection have viable viral loads and have been linked to several transmission cases. However, data on the viral loads in such individuals are lacking. We assessed the viral loads in asymptomatic individuals with SARS-CoV-2 infection in comparison with those in symptomatic patients with COVID-19.Study participants were recruited from a community facility designated for the isolation of patients with mild COVID-19 in South Korea. The presence of symptoms was evaluated with a questionnaire-based survey. Viral loads in the upper respiratory tract were measured with real-time reverse transcription-PCR (RT-PCR) targeting the E, RdRp and N genes of SARS-CoV-2, with a cycle threshold (Ct) value of 40 for determining positivity.In 213 patients with SARS-CoV-2 infection, 41 (19%) had remained asymptomatic from potential exposure to laboratory confirmation and admission; of them, 39 (95%) underwent follow-up RT-PCR testing after a median 13 days. In 172 symptomatic patients, 144 (84%) underwent follow-up RT-PCR testing. Twenty-one (54%) asymptomatic individuals and 92 (64%) symptomatic patients tested positive for SARS-CoV-2 at follow-up. Asymptomatic individuals and symptomatic patients did not show any significant differences in the mean Ct values of the E (31.15 vs 31.43; p>0.99), RdRp (32.26 vs 32.93; p=0.92) and N (33.05 vs 33.28; p>0.99) genes.Approximately one-fifth of the individuals without severe symptoms were asymptomatic, and their viral loads were comparable to those in symptomatic patients. A large proportion of mildly symptomatic patients with COVID-19 or asymptomatic individuals with SARS-CoV-2 showed persistent positive upper respiratory RT-PCR results at follow-up.
Pleural diseases and COVID-19: <i>ubi fumus, ibi ignis</i>
Authors: José M. Porcel
Journal: European Respiratory Journal (2020)

<b>There is both direct and circumstantial evidence that SARS-CoV-2 is responsible for the generation of pleural effusions and secondary spontaneous pneumothorax/pneumomediastinum</b>https://bit.ly/3gZqA7Z
TSPO-targeted PET and Optical Probes for the Detection and Localization of Premalignant and Malignant Pancreatic Lesions
Authors: Allison S. Cohen, Jun Li, Matthew R. Hight, Eliot McKinley, Allie Fu, Adria Payne, Yang Liu, Dawei Zhang, Qing Xie, Mingfeng Bai, Gregory D. Ayers, Mohammed Noor Tantawy, Jarrod A. Smith, Frank Revetta, M. Kay Washington, Chanjuan Shi, Nipun Merchant, H. Charles Manning
Journal: Clinical Cancer Research (2020)

Abstract Purpose: Pancreatic cancer is among the most aggressive malignancies and is rarely discovered early. However, pancreatic “incidentalomas,” particularly cysts, are frequently identified in asymptomatic patients through anatomic imaging for unrelated causes. Accurate determination of the malignant potential of cystic lesions could lead to life-saving surgery or spare patients with indolent disease undue risk. Current risk assessment of pancreatic cysts requires invasive sampling, with attendant morbidity and sampling errors. Here, we sought to identify imaging biomarkers of high-risk pancreatic cancer precursor lesions. Experimental Design: Translocator protein (TSPO) expression, which is associated with cholesterol metabolism, was evaluated in premalignant and pancreatic cancer lesions from human and genetically engineered mouse (GEM) tissues. In vivo imaging was performed with [18F]V-1008, a TSPO-targeted PET agent, in two GEM models. For image-guided surgery (IGS), V-1520, a TSPO ligand for near-IR optical imaging based upon the V-1008 pharmacophore, was developed and evaluated. Results: TSPO was highly expressed in human and murine pancreatic cancer. Notably, TSPO expression was associated with high-grade, premalignant intraductal papillary mucinous neoplasms (IPMNs) and pancreatic intraepithelial neoplasia (PanIN) lesions. In GEM models, [18F]V-1008 exhibited robust uptake in early pancreatic cancer, detectable by PET. Furthermore, V-1520 localized to premalignant pancreatic lesions and advanced tumors enabling real-time IGS. Conclusions: We anticipate that combined TSPO PET/IGS represents a translational approach for precision pancreatic cancer care through discrimination of high-risk indeterminate lesions and actionable surgery.
The Fundamental Ethical Concern Is Lack of School Resources to Ensure Student Well-Being
Authors: Judith Navratil, Carla D. Chugani, Dawn Golden, Barbara Fuhrman, Lisa M. Ripper, Janine Talis, Elizabeth Miller
Journal: The American Journal of Bioethics (2020)

"The Fundamental Ethical Concern Is Lack of School Resources to Ensure Student Well-Being." The American Journal of Bioethics, 20(10), pp. 65–66
Penile Metastasis From Prostate Cancer Detected by 18F-Fluorocholine PET/CT
Authors: Denise Bianchi, Alessio Rizzo, Mattia Bonacina, Alberto Zaniboni, Giordano Savelli
Journal: Clinical Nuclear Medicine (2020)

F-Fluorocholine (F-FCH) PET/CT is widely used to study patients affected by prostate cancer. F-FCH PET/CT is suitable for the detection of pelvic and abdominal nodal and skeletal metastases. Indeed, F-FCH PET/CT sensitivity for other organs, such as the liver and the urinary tract, is lowered by the radiopharmaceutical urinary washout and intense liver uptake. Herein, we report the case of a patient affected by oligometastatic prostate cancer in good clinical condition treated with total androgen blockade. F-FCH PET/CT showed a diffuse and intense uptake in the shaft of the penis, which was an evidence of a rare penile metastasis.
Imaging-based prostate cancer screening among BRCA mutation carriers—results from the first round of screening
Authors: N. Segal, Y. Ber, O. Benjaminov, S. Tamir, M. Yakimov, I. Kedar, E. Rosenbaum, S. Sela, R. Ozalvo, L. Shavit-Grievink, D. Keder, J. Baniel, D. Margel
Journal: Annals of Oncology (2020)

Male-carriers of BRCA1/2 gene mutations have an increased risk of prostate cancer (PCa) with a more aggressive phenotype. Current screening-guidelines suggest the use of prostate-specific antigen (PSA) only among BRCA2 carriers. Female carriers have extensive guidelines that include imaging. Our objective was to test the prevalence of PCa among BRCA carriers and examine screening strategies, using PSA and multiparametric magnetic resonance imaging (mpMRI).We recruited men aged 40-70 years with BRCA1/2 germline mutations and no prior history of prostate biopsy. All men underwent an initial round of screening which included PSA, and prostate mpMRI. PSA was considered elevated using an age-stratified threshold of ≥1 ng/ml for 40-50 years of age, ≥2 ng/ml for 50-60 years of age, and 2.5 ng/ml for 60-70 years of age. Men with elevated PSA and/or suspicious lesion on mpMRI were offered a prostate biopsy. PSA levels, MRI findings, PCa incidence, and tumor characteristics were evaluated. Decision curve analysis was used to compare screening strategies.We recruited 188 men (108 BRCA1, 80 BRCA2), mean age 54 years (9.8). One hundred and ten (57%) had either elevated age-stratified PSA (75; 40%), a suspicious MRI lesion (67; 36%), or both (32; 17%). Of these, 92 (85%) agreed to perform a prostate biopsy. Sixteen (8.5%) were diagnosed with PCa; 44% of the tumors were classified as intermediate- or high-risk disease. mpMRI-based screening missed only one of the cancers (6%), while age-stratified PSA would have missed five (31%). Decision curve analysis showed that mpMRI screening, regardless of PSA, had the highest net benefit for PCa diagnosis, especially among men younger than 55 years of age. We found no difference in the risk of PCa between BRCA1 and BRCA2 (8.3% versus 8.7%, P = 0.91). Ninety percent had a Jewish founder mutation, thus the results cannot be generalized to all ethnic groups.PCa is prevalent among BRCA carriers. Age may affect screening strategy for PCa in this population. Young carriers could benefit from initial MRI screening. BRCA carriers aged older than 55 years should use PSA and be referred to mpMRI if elevated.ClinicalTrial.gov ID: NCT02053805.
Intracranial Arterial Calcification: Prevalence, Risk Factors, and Consequences
Authors: Jonas W. Bartstra, Tim C. van den Beukel, Wim Van Hecke, Willem P.T.M. Mali, Wilko Spiering, Huiberdina L. Koek, Jeroen Hendrikse, Pim A. de Jong, Annemarie M. den Harder
Journal: Journal of the American College of Cardiology (2020)