tbuckley/cabot-search huggingface dataset:
Quality of life and late toxicities in germ-cell cancer patients after high-dose chemotherapy.
Authors: Thomas Wuendisch, Regina Naermann, Joerg Beyer, Anja Lorch
Journal: Journal of Clinical Oncology (2012)

4600 Background: The number of long term survivors after treatment for relapsed/refractory germ cell cancer (GCC) is increasing but little is known about quality of life (QOL) and late toxicities (LT). Methods: We assessed LT and QOL in GCC patients (pts), treated in a prospective, randomized, multicenter, phase III trial comparing single versus sequential high-dose chemotherapy (HDCT) (Lorch 2007). All 216 pts were asked to complete the European Organization of Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) prior to HDCT, 6 weeks after and yearly thereafter. Results were analyzed according to standard methods (Fayers 2001). In addition pts were contacted at a median of 76 months (range 45-109) after HDCT to obtain information about current social and professional activities as well as LT. Results: Among 216 pts, 92/216 (42%) were alive and without evidence of disease one year after randomization. Median age of pts was 34 years (range 15-56). A median of 4 conventional-dose cisplatin-based treatment cycles had been given prior to HDCT. Questionnaires and response to the survey were evaluable in 86/92 (93%) pts overall and in 59/86 (69%) pts more than 3 years after HDCT. Values for global health status, role functioning and emotional functioning declined during the first year after HDCT, increased in the following years, but did not reach the reference values from large samples of the general population in Norway (Hjermstad 1998). Pts after sequential HDCT scored better in a number of items (e.g. emotional-, cognitive-, social-functioning, fatigue and dyspnoea) in comparison to single HDCT including high-dose cyclophosphamide. Persisting polyneuropathy was reported in 59%, ototoxicity or tinnitus in 56%, erectile dysfunction in 24%, hypertension in 23%, hypercholesterinemia in 17%, diabetes mellitus in 6%, nephrotoxicity in 6%, myocardial infraction in 2% and second cancers in 1% of pts. Overall 82 % of pts were employed, 30% exercised regularly. Conclusions: HDCT has a negative impact on QOL, including social and professional life. Most common late toxicities were ototoxicity and polyneuropathy. Sequential HDCT without cyclophosphamide seems to result in a better outcome in respect to QOL.
Phase I/II Trial of Abiraterone Acetate (AA) in Estrogen Receptor (ERα) or Androgen Receptor (AR) Positive Metastatic Breast Cancer (MBC)
Authors: C.H.M. Ng, I. Macpherson, D. Rea, J. Spicer, A. Bowman, A. Jones, M. Dowsett, S.R.D. Johnston, N. Dobbs, J.S. de Bono
Journal: Annals of Oncology (2012)
Analysis of Price Transparency via National Cancer Institute–Designated Cancer Centers’ Chargemasters for Prostate Cancer Radiation Therapy
Authors: Ankit Agarwal, Anupriya Dayal, Sheetal M. Kircher, Ronald C. Chen, Trevor J. Royce
Journal: JAMA Oncology (2020)

A January 2019 price transparency mandate by the US Centers for Medicare & Medicaid Services (CMS) allows patients to look up the prices of cancer treatment services at hospitals across the United States.To investigate the value of the CMS price transparency rule in allowing patients with prostate cancer to comparison shop by price for radiation treatment services among National Cancer Institute-designated cancer centers.We identified the February 2019 publicly available price-containing chargemasters for National Cancer Institute-designated cancer centers. We isolated the charge per fraction of intensity-modulated radiation therapy used in standard prostate radiation treatment. We then calculated the mean (SD) charges of a 28-fraction course of prostate irradiation at all included hospitals. No human participants were included in this study.We analyzed the degree of price variation, the association of the mean price to the price paid by Medicare, and the association of the prices with the practice expense geographic practice cost index, as determined by Medicare.Of the 63 designated hospitals, 52 (84%) listed a price for simple intensity-modulated radiation therapy that is associated with standard prostate cancer radiation treatment. For a standard 28-fraction treatment, the charges ranged from $18 368 to $399 056, with a mean of $111 728.80 (10.1 times the price paid by Medicare). There was a weak positive association between price and geographic practice cost index, with an r2 value of 0.13 (P = .008).The availability of CMS-mandated hospital chargemasters and the descriptors used for simple intensity-modulated radiation therapy are not uniform, and the listed charges are highly variable. The association between listed charges and actual prices paid by patients or insurers is unclear, mitigating the value of the CMS rule for patients with prostate cancer who are receiving radiation therapy. This study suggests that implementation of the CMS price transparency policy may be insufficient to enable patients to estimate or compare prices for prostate cancer radiation treatment.
A resource for the detailed 3D mapping of white matter pathways in the marmoset brain
Authors: Cirong Liu, Frank Q. Ye, John D. Newman, Diego Szczupak, Xiaoguang Tian, Cecil Chern-Chyi Yen, Piotr Majka, Daniel Glen, Marcello G. P. Rosa, David A. Leopold, Afonso C. Silva
Journal: Nature Neuroscience (2020)
Randomized Multicenter Phase II Trial of Irinotecan and Bevacizumab as Neo-Adjuvant and Adjuvant to Temozolomide-Based Chemoradiation Versus Chemoradiation for Unresectable Glioblastoma (DEFINITIVE RESULTS OF THE TEMAVIR ANOCEF STUDY)
Authors: B. Chauffert, L. Feuvret, F. Bonnetain, L. Taillandier, D. Frappaz, J. Honnorat, M. Fabbro, M. Frenay, X. Durando, I. Tennevet, J.S. Guillamo, H. Tailla, R. Schott, F. Ghiringhelli, C. Campello, N. Tubiana-Mathieu, C. Dalban, J. Skrzypski, O. Chinot
Journal: Annals of Oncology (2012)
The Histological Importance of Signet Ring Cell and Mucinous Adenocarcinoma on Outcomes in Patients with Colorectal Cancer
Authors: S. Campos-Gomez, V. Rosas Camargo, R.A. Ramirez Fallas, J.H. Flores Arredondo, L. Morales Juarez, S.I. Perez Alvarez, D. Valdez Bocanegra, D. Huitzil Melendez
Journal: Annals of Oncology (2012)
Allocation of Physiologic Reserve Following Chemotherapy as a Marker of Frailty in Elderly Cancer Patients
Authors: M. Molina-Garido, C. Guillen-Ponce, M. Muñoz Sanchez, C. Ortega Ruiperez, A. Olaverri Hernandez, A. Carrato, J. Santiago Crespo
Journal: Annals of Oncology (2012)
Integrated Palliative and Medical Oncology Care for Patients with Small Cell Lung Cancer
Authors: L. Selvarajah, A.M. Sharkar, S. Toner, J. Clince, M. Triggs, N. Coleman, R.K. Morgan, R. McQuillan, L. Grogan, O.S. Breathnach
Journal: Annals of Oncology (2012)
High Frequency of BRCA 1/2 Mutations Among Israeli Non Ashkenazi Breast Cancer Patients
Authors: F. Elyan, O. Maimon, A.F. Salah, M. Sagi, L. Kaduri, I. Lerer, Y. Goldberg, T. Hamburger, D. Bercovich, T. Peretz-Yablonski
Journal: Annals of Oncology (2012)
Proinflammatory cytokine TNFα promotes HPV-associated oral carcinogenesis by increasing cancer stemness
Authors: Hannah S. Hong, Jonathan Akhavan, Sung Hee Lee, Reuben H. Kim, Mo K. Kang, No-Hee Park, Ki-Hyuk Shin
Journal: International Journal of Oral Science (2020)

Abstract High-risk human papillomaviruses (HPVs) are involved in the development of several human cancers, including oropharyngeal squamous cell carcinomas. However, many studies have demonstrated that HPV alone is not sufficient for the oncogenic transformation of normal human epithelial cells, indicating that additional cofactors are required for the oncogenic conversion of HPV-infected cells. Inasmuch as chronic inflammation is also closely associated with carcinogenesis, we investigated the effect of chronic exposure to tumor necrosis factor α (TNFα), the major proinflammatory cytokine, on oncogenesis in two immortalized oral keratinocyte cell lines, namely, HPV16-immortalized and human telomerase reverse transcriptase (hTERT)-immortalized cells. TNFα treatment led to the acquisition of malignant growth properties in HPV16-immortalized cells, such as (1) calcium resistance, (2) anchorage independence, and (3) increased cell proliferation in vivo. Moreover, TNFα increased the cancer stem cell-like population and stemness phenotype in HPV16-immortalized cells. However, such transforming effects were not observed in hTERT-immortalized cells, suggesting an HPV-specific role in TNFα-promoted oncogenesis. We also generated hTERT-immortalized cells that express HPV16 E6 and E7. Chronic TNFα exposure successfully induced the malignant growth and stemness phenotype in the E6-expressing cells but not in the control and E7-expressing cells. We further demonstrated that HPV16 E6 played a key role in TNFα-induced cancer stemness via suppression of the stemness-inhibiting microRNAs miR-203 and miR-200c. Overexpression of miR-203 and miR-200c suppressed cancer stemness in TNFα-treated HPV16-immortalized cells. Overall, our study suggests that chronic inflammation promotes cancer stemness in HPV-infected cells, thereby promoting HPV-associated oral carcinogenesis.
Mosaic Bioprostheses May Mimic Infective Endocarditis by PET/CTA
Authors: Albert Roque, María N. Pizzi, Nuria Fernández-Hidalgo, María Teresa González-Alujas, Remedios Ríos, Joan Castell-Conesa, Manuel Escobar, Ignacio Ferreira-González, Pilar Tornos, Santiago Aguadé-Bruix, Hug Cuellar-Calabria
Journal: JACC. Cardiovascular imaging (2020)
The need for clean air: The way air pollution and climate change affect allergic rhinitis and asthma
Authors: Ibon Eguiluz‐Gracia, Alexander G. Mathioudakis, Sabine Bartel, Susanne J. H. Vijverberg, Elaine Fuertes, Pasquale Comberiati, Yutong Samuel Cai, Peter Valentin Tomazic, Zuzana Diamant, Jørgen Vestbo, Carmen Galan, Barbara Hoffmann
Journal: Allergy (2020)

Abstract Air pollution and climate change have a significant impact on human health and well‐being and contribute to the onset and aggravation of allergic rhinitis and asthma among other chronic respiratory diseases. In Westernized countries, households have experienced a process of increasing insulation and individuals tend to spend most of their time indoors. These sequelae implicate a high exposure to indoor allergens (house dust mites, pets, molds, etc), tobacco smoke, and other pollutants, which have an impact on respiratory health. Outdoor air pollution derived from traffic and other human activities not only has a direct negative effect on human health but also enhances the allergenicity of some plants and contributes to global warming. Climate change modifies the availability and distribution of plant‐ and fungal‐derived allergens and increases the frequency of extreme climate events. This review summarizes the effects of indoor air pollution, outdoor air pollution, and subsequent climate change on asthma and allergic rhinitis in children and adults and addresses the policy adjustments and lifestyle changes required to mitigate their deleterious effects.
Targeted camptothecin delivery via silicon nanoparticles reduces breast cancer metastasis
Authors: Marietta Landgraf, Christoph A. Lahr, Ishdeep Kaur, Abbas Shafiee, Alvaro Sanchez-Herrero, Phillip W. Janowicz, Akhilandeshwari Ravichandran, Christopher B. Howard, Anna Cifuentes-Rius, Jacqui A. McGovern, Nicolas H. Voelcker, Dietmar W. Hutmacher
Journal: Biomaterials (2020)
Clinicopathological and Molecular Correlates of HER2 Expression, PIK3CA Mutations and EBV Infection Involved in the PI3K-AKT Pathway in Gastric Cancer
Authors: Y. Sukawa, H. Yamamoto, H. Kunimoto, K. Nosho, H. Suzuki, Y. Adachi, T. Nobuoka, M. Kawayama, M. Mikami, T. Matsuno, T. Hasegawa, K. Hirata, Y. Shinomura
Journal: Annals of Oncology (2012)
Nutritional support for children during critical illness: European Society of Pediatric and Neonatal Intensive Care (ESPNIC) metabolism, endocrine and nutrition section position statement and clinical recommendations
Authors: Lyvonne N. Tume, Frederic V. Valla, Koen Joosten, Corinne Jotterand Chaparro, Lynne Latten, Luise V. Marino, Isobel Macleod, Clémence Moullet, Nazima Pathan, Shancy Rooze, Joost van Rosmalen, Sascha C. A. T. Verbruggen
Journal: Intensive Care Medicine (2020)

Nutritional support is considered essential for the outcome of paediatric critical illness. There is a lack of methodologically sound trials to provide evidence-based guidelines leading to diverse practices in PICUs worldwide. Acknowledging these limitations, we aimed to summarize the available literature and provide practical guidance for the paediatric critical care clinicians around important clinical questions many of which are not covered by previous guidelines.To provide an ESPNIC position statement and make clinical recommendations for the assessment and nutritional support in critically ill infants and children.The metabolism, endocrine and nutrition (MEN) section of the European Society of Pediatric and Neonatal Intensive Care (ESPNIC) generated 15 clinical questions regarding different aspects of nutrition in critically ill children. After a systematic literature search, the Scottish Intercollegiate Guidelines Network (SIGN) grading system was applied to assess the quality of the evidence, conducting meta-analyses where possible, to generate statements and clinical recommendations, which were then voted on electronically. Strong consensus (> 95% agreement) and consensus (> 75% agreement) on these statements and recommendations was measured through modified Delphi voting rounds.The final 15 clinical questions generated a total of 7261 abstracts, of which 142 publications were identified relevant to develop 32 recommendations. A strong consensus was reached in 21 (66%) and consensus was reached in 11 (34%) of the recommendations. Only 11 meta-analyses could be performed on 5 questions.We present a position statement and clinical practice recommendations. The general level of evidence of the available literature was low. We have summarised this and provided a practical guidance for the paediatric critical care clinicians around important clinical questions.
Differences in Central Line–Associated Bloodstream Infection Rates Based on the Criteria Used to Count Central Line Days
Authors: David Scheinker, Andrew Ward, Andrew Y. Shin, Grace M. Lee, Roshni Mathew, Lane F. Donnelly
Journal: JAMA (2020)

This study uses electronic health record (EHR) data to evaluate differences in central line–associated bloodstream infection (CLABSI) rates by how central line days are counted: once a day at a fixed time for all patients; a sampling-based approximation; or a validated electronic count.
Stepwise evolution and convergent recombination underlie the global dissemination of carbapenemase-producing Escherichia coli
Authors: Rafael Patiño-Navarrete, Isabelle Rosinski-Chupin, Nicolas Cabanel, Lauraine Gauthier, Julie Takissian, Jean-Yves Madec, Monzer Hamze, Remy A. Bonnin, Thierry Naas, Philippe Glaser
Journal: Genome Medicine (2020)

Carbapenem-resistant Enterobacteriaceae are considered by WHO as "critical" priority pathogens for which novel antibiotics are urgently needed. The dissemination of carbapenemase-producing Escherichia coli (CP-Ec) in the community is a major public health concern. However, the global molecular epidemiology of CP-Ec isolates remains largely unknown as well as factors contributing to the acquisition of carbapenemase genes.We first analyzed the whole-genome sequence and the evolution of the E. coli sequence type (ST) 410 and its disseminated clade expressing the carbapenemase OXA-181. We reconstructed the phylogeny of 19 E. coli ST enriched in CP-Ec and corresponding to a total of 2026 non-redundant isolates. Using the EpiCs software, we determined the significance of the association between specific mutations and the acquisition of a carbapenemase gene and the most probable order of events. The impact of the identified mutations was assessed experimentally by genetic manipulations and phenotypic testing.In 13 of the studied STs, acquisition of carbapenemase genes occurred in multidrug-resistant lineages characterized by a combination of mutations in ftsI encoding the penicillin-binding protein 3 and in the porin genes ompC and ompF. Mutated ftsI genes and a specific ompC allele related to that from ST38 inducing reduced susceptibility to diverse β-lactams spread across the species by recombination. We showed that these mutations precede in most cases the acquisition of a carbapenemase gene. The ompC allele from ST38 might have contributed to the selection of CP-Ec disseminated lineages within this ST. On the other hand, in the pandemic ST131 lineage, CP-Ec were not associated with mutations in ompC or ftsI and show no signs of dissemination.Lineages of CP-Ec have started to disseminate globally. However, their selection is a multistep process involving mutations, recombination, acquisition of antibiotic resistance genes, and selection by β-lactams from diverse families. This process did not yet occur in the high-risk lineage ST131.
Spanish Melanoma Multidisciplinary Group (GEM) Experience with Ipilimumab (IPI) in the Expanded Access Programme (EAP)
Authors: S. Martin Algarra, L. Alonso, J. Valdivia, A. Garcia Castaño, V. Escrig, P. Mut, A. Ballesteros, T. Puertolas, E. Ortega, A. Berrocal
Journal: Annals of Oncology (2012)
Multicenter Retrospective Analysis of Systemic Chemotherapy for Advanced Poorly Differentiated Neuroendocrine Carcinoma of Digestive System
Authors: A. Kasuga, T. Yamaguchi, N. Machida, H. Takahashi, K. Sudo, T. Nishina, H. Nishisaki, K. Ishido, T. Okuno, T. Moriwaki, H. Kawai, S. Kobayashi, A. Hosokawa, J. Furuse, N. Boku
Journal: Annals of Oncology (2012)
Electrochemotherapy for Chest Wall Recurrence From Breast Cancer in Older Women: Analysis of 55 Patients
Authors: L.G. Campana, S. Galuppo, S. Valpione, C. Falci, L. Corti, A. Brunello, G. Zavagno, C. Ghiotto, C.R. Rossi
Journal: Annals of Oncology (2012)
Effectiveness of post-partum family planning interventions on contraceptive use and method mix at 1 year after childbirth in Kinshasa, DR Congo (Yam Daabo): a single-blind, cluster-randomised controlled trial
Authors: Nguyen Toan Tran, Armando Seuc, Béatrice Tshikaya, Maurice Mutuale, Sihem Landoulsi, Brigitte Kini, Bernadette Mbu Nkolomonyi, Jean Nyandwe Kyloka, Félicité Langwana, Asa Cuzin-Kihl, James Kiarie, Mary Eluned Gaffield, Rachel Yodi, Désiré Mashinda Kulimba
Journal: The Lancet Global Health (2020)

In rural Burkina Faso, a package of six low-technology, post-partum contraceptive interventions (ie, refresher training for providers, a counselling tool, supportive supervision, daily availability of contraceptive services, client appointment cards, and invitation letters to attend appointments for partners), aimed at strengthening existing primary health-care services and enhancing demand for them, doubled the use of modern contraceptives at 12 months post partum (ie, 55% uptake in intervention recipients vs 29% in routine-care users). This study assessed the effect of a similar package but in urban settings of Kinshasa province, Democratic Republic of the Congo, in an effort to reduce the unmet need for post-partum family planning.
Airway brush cells generate cysteinyl leukotrienes through the ATP sensor P2Y2
Authors: Saltanat Ualiyeva, Nils Hallen, Yoshihide Kanaoka, Carola Ledderose, Ichiro Matsumoto, Wolfgang G. Junger, Nora A. Barrett, Lora G. Bankova
Journal: Science Immunology (2020)

Aeroallergens and ATP elicit cysteinyl leukotrienes from nasal brush cells through the purinergic receptor P2Y2.
Intratumoral gene expression of 5-fluorouracil pharmacokinetics related enzymes in stage I and II non-small cell lung cancer patients treated with uracil-tegaful after surgery.
Authors: Keisuke Eguchi, Tomohiko Abiko, Mitsuo Kohno, Makoto Sawafuji, Hirotoshi Horio, Toshinori Hashizume, Mitsuo Nakayama, Ryoichi Kato, Masafumi Kawamura
Journal: Journal of Clinical Oncology (2013)

7536 Background: It is believed through meta-analysis that the adjuvant chemotherapy with oral administration of uracil-tegafur combination drug (manufactured as UFT) yielded better survival than surgery alone in early stage non-small cell lung cancer patients (NSCLC) in Japan. However, no promising bio-marker, which can predict the benefit of UFT use in NSCLC patients, has been found. This clinical trial was designed to evaluate the relationship between the intratumoral gene expression of the five-fluorouracil pharmacokinetics related enzymes such as thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), orate phosphoribosyltransferase (OPRT) and thymidine phosphorylase (TP), and clinical outcomes in patients to whom UFT was administered for 2 years after surgery. Methods: From June 2004 to September 2007, 236 NSCLC patients who underwent complete resection of a pathological stage IA (maximum diameter of 2cm or more), IB and II (according to the 1997 UICC TNM classification) were eligible in this study. Other inclusion criteria were age of 20 to 80 years, ECOG PS of 0 or 1 and feasible oral UFT administration within 8 weeks after surgery. Total RNA was extracted from formalin-fixed lung cancer cell sample obtained with micro-dissection method. Gene expression was examined using quantified fluorescence-based real time revers transcription-polymerase chain reaction assay. Results: 131 (63%) patients completed 2 year administration of UFT. 73 (31%) patients had recurrence during 5 years follow-up and 48 (73%) patients among them were treated with chemotherapy including platinum. The 5-year disease free survival (DFS) and overall survival (OS) rates in all patients were 66.7% and 83.7%, respectively. A cox multivariate analysis revealed pathological stage (HR: 0.4463; p=0.034), TS expression status (HR: 0.469; p=0.021) and DPD expression status (HR: 1.956; p=0.048) to be prognostic for DFS but no factors to be prognostic for OS. Conclusions: This study suggested that TS and DPD mRNA expression in the tumor were possible prognostic biomarkers for postoperative adjuvant chemotherapy with UFT in stage I-II NSCLC. Clinical trial information: 15-65-1.
EGFR and P53 Expression in Androgen Receptor (AR)-Positive, Triple Negative Breast Cancer (TNBC)
Authors: A. Gucalp, G. Gupta, S. Patil, Y.H. Wen, M. Akram, E. Brogi, S. Powell, A. Ho, C.A. Hudis, T.A. Traina
Journal: Annals of Oncology (2012)
Cabazitaxel (CBZ) Shows Superior Antitumor Efficacy Over Docetaxel in a Hormone-Resistant Prostate Tumor Xenograft Model (HID28)
Authors: L. Bourré, D. Nicolle, M. Legrier, V. Yvonnet, J. Charpentier, M. Poupon, P. Vrignaud, S. Oudard, J.-G. Judde
Journal: Annals of Oncology (2012)
Aberrant ALK1 Mrna Expression Patterns are Associated with Poor Prognosis in Non-Small Cell Lung Cancer (NSCLC) Patients. A Hellenic Cooperative Oncology Group Study
Authors: V. Kotoula, M. Bobos, S. Lakis, K. Papadopoulou, S. Levva, D. Repana, V. Karavasilis, E. Samantas, P. Kosmidis, G. Fountzilas
Journal: Annals of Oncology (2012)