tbuckley/cabot-search huggingface dataset:
Current update on nanoplatforms as therapeutic and diagnostic tools: A review for the materials used as nanotheranostics and imaging modalities
Authors: Panoraia I. Siafaka, Neslihan Üstündağ Okur, Ioannis D. Karantas, Mehmet Evren Okur, Evren Atlıhan Gündoğdu
Journal: Asian Journal of Pharmaceutical Sciences (2020)

In the last decade, the use of nanotheranostics as emerging diagnostic and therapeutic tools for various diseases, especially cancer, is held great attention. Up to date, several approaches have been employed in order to develop smart nanotheranostics, which combine bioactive targeting on specific tissues as well as diagnostic properties. The nanotheranostics can deliver therapeutic agents by concomitantly monitor the therapy response in real-time. Consequently, the possibility of over- or under-dosing is decreased. Various non-invasive imaging techniques have been used to quantitatively monitor the drug delivery processes. Radiolabeling of nanomaterials is widely used as powerful diagnostic approach on nuclear medicine imaging. In fact, various radiolabeled nanomaterials have been designed and developed for imaging tumors and other lesions due to their efficient characteristics. Inorganic nanoparticles as gold, silver, silica based nanomaterials or organic nanoparticles as polymers, carbon based nanomaterials, liposomes have been reported as multifunctional nanotheranostics. In this review, the imaging modalities according to their use in various diseases are summarized, providing special details for radiolabeling. In further, the most current nanotheranostics categorized via the used nanomaterials are also summed up. To conclude, this review can be beneficial for medical and pharmaceutical society as well as material scientists who work in the field of nanotheranostics since they can use this research as guide for producing newer and more efficient nanotheranostics.
ENDOSCOPIC SUBMUCOSAL DISSECTION (ESD) FOR GASTRIC LESIONS: A SINGLE ITALIAN CENTER EXPERIENCE
Authors: R Maselli, R Palma, PA Galtieri, VM Ormando, M Spadaccini, S Carrara, M Di Leo, G Pellegatta, EC Ferrara, A Fugazza, A Anderloni, A Repici
Journal: Endoscopy (2020)

Aims The aim of this study is to report the short- and long-term outcomes of a cohort of patients from a single Italian center who underwent gastric ESD.
ANALYSIS OF PERFORMANCE MEASURES IN DEVICE ASSISTED ENTEROSCOPY (DAE)
Authors: AC Gomes, R Pinho, A Ponte, A Rodrigues, M Sousa, JC Silva, E Afecto, J Carvalho
Journal: Endoscopy (2020)

Aims The European Society of Gastrointestinal Endoscopy (ESGE) small-bowel working group identified a list of performance measures for small-bowel endoscopy with the final goal of quality improvement. The aim of this study is to analyze the performance measures for device assisted enteroscopy (DAE) at a service level.
Association of Noncognitive Life Skills With Mortality at Middle and Older Ages in England
Authors: Andrew Steptoe, Sarah E. Jackson
Journal: JAMA Network Open (2020)

<h3>Importance</h3> Noncognitive life skills are patterns of behavior, thoughts, and feelings that complement cognitive ability in promoting positive economic and educational outcomes. These positive attributes have been associated with favorable social and health outcomes at older ages, but their combined association with survival is not known. <h3>Objectives</h3> To evaluate the association of the combination of 5 noncognitive life skills with mortality, and to explore the role of sociodemographic, health, cognitive, and behavioral factors in explaining associations. <h3>Design, Setting, and Participants</h3> This cohort study used data from wave 5 of the English Longitudinal Study of Ageing, conducted in 2010. Participants included adults 52 years and older. Associations of scores on 5 noncognitive life skills, including conscientiousness, perseverance, emotional stability, optimism, and control, with all-cause mortality were analyzed for a mean (SD) of 7.2 (1.3) years. Data analyses were completed in November 2019. <h3>Exposures</h3> Response to wave 5 of the English Longitudinal Study of Ageing. <h3>Main Outcomes and Measures</h3> Noncognitive life skills scores, including conscientiousness, perseverance, emotional stability, optimism, and control, were measured by questionnaire. The main outcome was all-cause mortality, and the associations with noncognitive life skills scores were analyzed using Cox proportional hazards regressions models to estimate hazard ratios per 1-SD increase in score. <h3>Results</h3> A total of 7850 participants (mean [SD] age, 66.5 [9.0] years; 4333 [55.2%] women) were included. Combined life skill score was positively associated with survival, with a hazard ratio of 0.81 (95% CI, 0.72-0.90) per 1-SD increase in positive attributes after adjustment for age, sex, race/ethnicity, childhood socioeconomic status, educational attainment, baseline chronic disease, depressive symptoms, cognitive function, mobility impairment, social isolation, smoking, physical activity, alcohol intake, and fruit and vegetable consumption (<i>P</i> &lt; .001). Excluding deaths during 24 months after baseline as a check for reverse causation showed the same pattern (adjusted hazard ratio, 0.79; 95% CI, 0.70-0.89;<i>P</i> &lt; .001). Associations were maintained after each life skill was omitted in turn from the aggregate score, indicating that no single positive attribute accounted for the protective association. <h3>Conclusions and Relevance</h3> These findings suggest that noncognitive life skills are associated with survival at older ages. Whether training and education programs could enhance these attributes and influence mortality risk is not known, but fostering and maintaining life skills may be important in later life.
ENDOSCOPIC FULL-THICKNESS RESECTION FOR THE MANAGEMENT OF DIFFICULT COLORECTAL LESIONS: A PROSPECTIVE COHORT STUDY
Authors: S Sferrazza, M Jovani, F Vieceli, R Di Mitri, E Conte, A Michielan, G de Pretis
Journal: Endoscopy (2020)

Aims The aim of this study is to evaluate the safety and efficacy of endoscopic full-thickness resection for the management of difficult colonic lesions.
Covid-19 in Pakistan and potential repercussions for the world: is the infection on the verge of endemicity?
Authors: Amjad Ali, Ma Zhongren, Zulqarnain Baloch
Journal: BMJ (2020)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Covid-19 in Pakistan and potential repercussions for the world: is the infection on the verge of endemicity? Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
PERFORATION OF THE COMMON BILE DUCT DURING SPYGLASS CHOLANGIOSCOPY IN A PATIENT WITH IGG4-RELATED SCLEROSING CHOLANGITIS (IGG4-SC)
Authors: K Paraskeva, V Papastergiou, A Giannakopoulos, S Petraki, C Triantopoulou
Journal: Endoscopy (2020)

Aims SpyGlass cholangioscopy is increasingly performed for the evaluation of indeterminate biliary lesions. Although it has demonstrated favorable safety, additional complications are expected to arise with expanded use of this technology. We describe an uncommon case of common bile duct (CBD) perforation associated with cholangioscopy.
Vitamin B<i>12</i> Deficiency
Authors: S Moll
Journal: New England Journal of Medicine (1996)

Figure 1. A 72-year-old man with a several-week history of fatigue, loss of appetite, and feeling feverish presented at the hospital with severe pallor and signs of left and right ventricular failure. Neurologic examination disclosed poor short-term memory and decreased sense of vibration in the legs.An electrocardiogram showed changes consistent with the presence of cardiac ischemia. The hemoglobin level was 3.7 g per deciliter, with a mean corpuscular volume of 103 μm3, a white-cell count of 3200 per cubic millimeter, and a platelet count of 57,000 per cubic millimeter. The peripheral-blood film showed the typical changes of vitamin . . .
Improvement in endothelial function by angiotensin converting enzyme inhibition in insulin-dependent diabetes mellitus.
Authors: G O'Driscoll, D Green, J Rankin, K Stanton, R Taylor
Journal: Journal of Clinical Investigation (1997)

We postulated that nitric oxide (NO)-mediated endothelial function would be improved by acute and short-term treatment with an angiotensin converting enzyme (ACE) inhibitor in patients with type I diabetes mellitus, in whom endothelial function is depressed. Nine type I diabetic patients and eight healthy subjects underwent forearm blood flow measurement using strain gauge plethysmography during intraarterial infusion of incremental doses of endothelium-dependent (acetylcholine [ACh]) and endothelium-independent (sodium nitroprusside [SNP]) vasodilators. Pretreatment ACh responses were depressed in diabetic patients relative to the normal subjects (P < 0.05). No difference between the groups was evident in response to SNP. Acute ACE inhibition (with intrabrachial enalaprilat) enhanced ACh responses in the diabetic patients (P < 0.005), with a further improvement evident after 1 mo of oral therapy with enalapril (P < 0.001) when ACh responses were normalized. ACE inhibition did not affect SNP responses. We conclude that acute administration of the ACE inhibitor, enalaprilat, enhances NO-mediated endothelial function in type I diabetic patients, with further improvement evident after 4 wk of enalapril therapy.
BLEEDING RISK AFTER ENDOSONOGRAPHIC (EUS) PUNCTURE OF PANCREAS MASSES- COMPARISON BETWEEN ASPIRATION (FNA) AND BIOPSY (FNB) FINE NEEDLES
Authors: M Razpotnik, B Simona, M Kutilek, G Essler, J Weber-Eibel, A Maieron, M Peck-Radosavljevic
Journal: Endoscopy (2020)

Aims To compare the bleeding rate between EUS-FNA and -FNB for solid and cystic pancreatic masses regarding coagulation parameters and use of antithrombotic agents in two Austrian centers.
Intraarticular Adeno‐Associated Virus Serotype AAV‐PHP.S–Mediated Chemogenetic Targeting of Knee‐Innervating Dorsal Root Ganglion Neurons Alleviates Inflammatory Pain in Mice
Authors: Sampurna Chakrabarti, Luke A. Pattison, Balint Doleschall, Rebecca H. Rickman, Helen Blake, Gerard Callejo, Paul A. Heppenstall, Ewan St. John Smith
Journal: Arthritis & Rheumatology (2020)

Objective Joint pain is the major clinical symptom of arthritis that affects millions of people. Controlling the excitability of knee‐innervating dorsal root ganglion ( DRG ) neurons (knee neurons) could potentially provide pain relief. We undertook this study to evaluate whether the newly engineered adeno‐associated virus ( AAV ) serotype, AAV ‐ PHP .S, can deliver functional artificial receptors to control knee neuron excitability following intraarticular knee injection. Methods The AAV ‐ PHP .S virus, packaged with dT omato fluorescent protein and either excitatory (G q ) or inhibitory (G i ) designer receptors exclusively activated by designer drugs ( DREADD s), was injected into the knee joints of adult mice. Labeling of DRG neurons with AAV ‐ PHP .S from the knee was evaluated using immunohistochemistry. The functionality of G q ‐ and G i ‐ DREADD s was evaluated using whole‐cell patch clamp electrophysiology on acutely cultured DRG neurons. Pain behavior in mice was assessed using a digging assay, dynamic weight bearing, and rotarod performance, before and after intraperitoneal administration of the DREADD activator, Compound 21. Results We showed that AAV ‐ PHP .S can deliver functional genes into ~7% of lumbar DRG neurons when injected into the knee joint in a similar manner to the well‐established retrograde tracer, fast blue. Short‐term activation of AAV ‐ PHP .S–delivered G q ‐ DREADD increased excitability of knee neurons in vitro ( P = 0.02 by unpaired t ‐test), without inducing overt pain in mice when activated in vivo. By contrast, in vivo G i ‐ DREADD activation alleviated digging deficits induced by Freund's complete adjuvant–mediated knee inflammation ( P = 0.0002 by repeated‐measures analysis of variance [ ANOVA ] followed by Holm‐Sidak multiple comparisons test). A concomitant decrease in knee neuron excitability was observed in vitro ( P = 0.005 by ANOVA followed by Holm‐Sidak multiple comparisons test). Conclusion We describe an AAV ‐mediated chemogenetic approach to specifically control joint pain, which may be utilized in translational arthritic pain research.
IMPLICATION OF KI-67 IMMUNOHISTOCHEMISTRY FOR MANAGEMENT OF INTRAMUCOSAL NEOPLASIA IN BARRETT’S ESOPHAGUS
Authors: Y Ikenoyama, T Shimizu, H Kawachi, J Fujisaki
Journal: Endoscopy (2020)

Aims Histological assessment of intramucosal neoplasia in Barrett’s esophagus is important for appropriate treatment. High-grade dysplasia, which is nearly identical to intramucosal non-invasive adenocarcinoma in Japan, and invasive adenocarcinoma are recommended to be treated immediately, although their histological criteria remain subjective and poor reproducibility has not been resolved. We aimed to clarify the potential of Ki-67 and p53 immunohistochemistry as an alternative method to conventional histological evaluation.
The colonoscopic leakage model: a new model to study the intestinal wound healing at molecular level
Authors: Radu Bachmann, Matthias Van Hul, Daniel Leonard, Nathalie M Delzenne, Alex Kartheuser, Patrice D Cani
Journal: Gut (2020)

We describe a novel, fast-track, innovative intestinal wound healing model developed in mice called the ‘colonoscopic leakage model’. This model uses a colonoscopic biopsy grasper to make a controlled transmural perforation in the colon. Similar to other classic anastomotic leakage models, we observed about 50% incidence of peritonitis, although this model is less invasive, faster and avoids intestinal occlusion as well as massive bodyweight loss. Therefore, this preclinical model could be used to test potential therapeutic agents and to investigate the different molecular wound healing mechanisms.

Despite significant progress in the medical field, the mechanisms of healing of a wound in the GI tract are still not completely identified, which limits the options for positive interventions at the local level to support the healing processes.

Even though many influencing factors have been studied, it is very challenging to acquire knowledge of the local pathophysiology and to study the impact of different pharmacological and microbiological conditions at the molecular level. To overcome these difficulties, the use of experimental models that help in understanding the local conditions has become indispensable.

The models proposed in the literature to study the mechanisms of intestinal wound healing are mainly anastomotic leakage models. Among them, the one proposed by Pommergaard et al 1 is the most commonly used technique (online supplementary video 1). This rodent model is based on the variation of the number of intestinal anastomotic sutures after segmental colonic resection (5 vs 8 stitches) in order to achieve a probability of 50% of anastomotic leakage (figure 1A and online supplementary videos 2–4) and peritonitis in the anastomotic leakage group.

### Supplementary video

[gutjnl-2020-321234supp001.mov]

### Supplementary video

[gutjnl-2020-321234supp002.mov]

### Supplementary video

[gutjnl-2020-321234supp003.mov]

### Supplementary video

[gutjnl-2020-321234supp004.mov]



Figure 1 
Anastomotic leakage model. (A) The anastomotic leakage model is feasible with an anastomotic leakage and …
Extreme Risk Protection Orders Intended to Prevent Mass Shootings
Authors: Garen J. Wintemute, Veronica A. Pear, Julia P. Schleimer, Rocco Pallin, Sydney Sohl, Nicole Kravitz-Wirtz, Elizabeth A. Tomsich
Journal: Annals of Internal Medicine (2019)

Extreme risk protection orders (ERPOs) are urgent, individualized interventions aimed to reduce firearm access when risk for imminent firearm injury is high. In January 2016, California enacted the...
Preclinical antihypertensive efficacy and immunogenicity in humans of a vaccine against angiotensin II based on virus-like particles (VLPs)
Authors: A C Tissot, P M Ambuhl, A Fulurija, P Maurer, G T Jennings, J Nussberger, R Sabat, H D Volk, F Wagner, V Nief, C Schellekens, K Sladko, T Pfister, M Rettenbacher, P Muller, M F Bachmann
Journal: Circulation (2005)
The Army Medical Museum and Library.
Authors: D L Huntingdon
Journal: JAMA (1883)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PER-ORAL ENDOSCOPIC TUNNELING FOR RESTORATION OF THE ESOPHAGUS (POETRE) IN THE MANAGEMENT OF A 45MM COMPLETE ESOPHAGEAL OBSTRUCTION
Authors: C Félix, P Barreiro, JA Rodrigues, I Carina, R Mendo, L Maia, R Kuttner-Magalhães, I Pedroto, C Chagas
Journal: Endoscopy (2020)

A 54-year-old man submitted to chemoradioterapy presented with aphagia due to a long complete post-radioterapy esophageal obstruction(CEO). Simultaneous-dual-endoscope procedure(one via the mouth and another simultaneously inserted through the PEG-tube-tract) was performed. Retrograde submucosal tunneling was started distal to the obstruction, and the fibrotic tissue was carefully dissected under endoscopic and fluoroscopic guidance. Once the two endoscopes were in close proximity, fibrotic tissue was incised, restoring esophageal continuity, and a stent was placed, maintaining a new esophageal lumen.
EUS-GUIDED ANGIOTHERAPY OF THREE CASES OF BLEEDING GISTS
Authors: R Romero-Castro, VA Jimenez-Garcia, P Hergueta-Delgado, A Garrido-Serrano, R Aparcero-Lopez, S Pereira-Gallardo, MJ Carrillo-Ramos, JL Caceres-Galan, A Caunedo-Alvarez
Journal: Endoscopy (2020)

Aims Management of bleeding GISTs is challenging. We report three cases of bleeding GISTs successfully treated under EUS-guidance.
ACUTE PANCREATITIS AS A RARE COMPLICATION OF RUPTURE OF HYDATID LIVER CYST
Authors: FZ Hamdoun, N Lahmidani, M Lahlali, A Lamine, H Abid, ME Yousfi, M Abkari, A Ibrahimi, DA Benajah
Journal: Endoscopy (2020)

Aims The purpose of our work is to show the interest and outcomes of the management of liver hydatid cyst complicated with acute pancreatitis.
The Importance of Pediatric Safety in Tetrahydrocannabinol Education
Authors: Robert Goodnough, Karla Canseco
Journal: JAMA Internal Medicine (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
THE NATIONAL PERFORMANCE IN THE MANAGEMENT OF COMMON BILE DUCT STONES IN ENGLAND
Authors: H Martin, R Sturgess, A Ceney, TE Menabawey, C Parisinos, S Pereira, G Johnson, M Chapman, G Webster
Journal: Endoscopy (2020)

Aims Common Bile Duct Stones (CBDS) is a common indication for ERCP. There are British Society of Gastroenterology endorsed national standards for clearance rates with the expectation that 75% or more of initial ERCPs for CBDS should result in stone clearance(1). This paper will examine the NHS data set from all trusts in England to assess the treatment of CBDS.
INFLUENCE OF INDIVIDUAL PROTON PUMP INHIBITORS ON CLINICAL OUTCOMES IN CORONARY ARTERY DISEASE PATIENTS RECEIVING CLOPIDOGREL: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: D Lee, BJ Kim, HS Park, EM Lee, JW Lim, SN Hong
Journal: Endoscopy (2020)

Aims We aimed to determine efficacy and safety of clopidogrel only vs. clopidogrel added PPIs in the treatment of patients with percutaneous coronary intervention.
Allosteric Modulation of G Protein–Coupled Receptors
Authors: Lauren T. May, Katie Leach, Patrick M. Sexton, Arthur Christopoulos
Journal: The Annual Review of Pharmacology and Toxicology (2006)

The past decade has witnessed a significant growth in the identification of allosteric modulators of G protein–coupled receptors (GPCRs), i.e., ligands that interact with binding sites that are topographically distinct from the orthosteric site recognized by the receptor's endogenous agonist. Because of their ability to modulate receptor conformations in the presence of orthosteric ligand, allosteric modulators can “fine-tune” classical pharmacological responses. This is advantageous in terms of a potential for engendering greater GPCR subtype-selectivity, but represents a significant challenge for detecting and validating allosteric behaviors. Although allosteric sites need not have evolved to accommodate endogenous ligands, there are a number of examples of where such modulators have been shown to contribute to physiological or pathophysiological processes. Studies are also beginning to unravel the structural basis of allosteric modulation of GPCRs. It remains to be determined whether such modulation represents interactions within monomers versus across dimers.
COMPARING THE ACCURACY OF EUS AND CT IN STAGING OF ESOPHAGEAL CANCER
Authors: DH Lee, HI Shim, CM Shin, H Yoon, YS Park, N Kim, H Song, J Kim
Journal: Endoscopy (2020)

Aims Endoscopic ultrasound (EUS) is a suitable device for staging of esophageal cancers. However, chest computed tomography (CT) has traditionally been the standard diagnostic modality for malignancies. This study aimed was to compare the accuracies of EUS and chest CT in T and N staging of esophageal cancers.
AFFERENT LIMB VOLVULUS POST IPAA
Authors: S Gavriel, T Emmanouil, P Alepas, G Sourtse, IS Papanikolaou
Journal: Endoscopy (2020)

Aims Patients operated with total colectomy and ileal pouch anal anastomosis (IPAA) for refractory ulcerative colitis often present with episodes of small bowel obstruction after different period of time post surgically. We present two cases of patients presented with afferent limb obstruction of the pouch.