tbuckley/cabot-search huggingface dataset:
Comparative evaluation of colonoscopy, fecal immunochemical test, and a novel risk-adapted approach for colorectal cancer screening: preliminary baseline results of a multicentre randomised controlled trial (Target-C)
Authors: Hongda Chen, Ni Li, Ming Lu, Jufang Shi, Jiansong Ren, Chengcheng Liu, Yueming Zhang, Zheng Jiang, Zhihui Zhang, Min Dai
Journal: The Lancet (2019)
Brain Magnetic Resonance Imaging and Angiography Findings in Ugandan Children with Sickle Cell Anemia; A Cross Sectional Study
Authors: Richard Idro, Nancy S. Green, Deogratias Munube, Linda Rosset Buluma, Bridget Kebirungi, Robert Opoka, Paul Bangirana, Ezekiel Mupere, Edward Kayongo, Rogers Sekibira, Philip Kasirye, Samson K. Lubowa, Michael Kawooya, Phillip LaRussa, Frank Minja
Journal: Blood (2018)
Abstract 584: DJ-1 Confers Protection Against Ischemic Injury by Preserving the Activity of Thioredoxin
Authors: Yvanna Pantner, Yuuki Shimizu, Rohini Polavarapu, Lian Li, Lih-Shen Chin, John Calvert
Journal: Circulation Research (2019)

Background: DJ-1 is a cytoprotective protein expressed in the heart. It can act as an antioxidant in oxidative stress conditions where it is cleaved and converted into an active protease. DJ-1 and Thioredoxin (Trx1), another antioxidant, are known to act on related targets, both playing a role in opposing the apoptosis signaling kinase 1 (ASK1) signaling pathway. We recently found that the cleaved form of DJ-1 attenuates ischemia-reperfusion (I/R)-induced heart failure by reducing glycative stress. Thus, the purpose of this study was to examine the role of DJ-1’s antiglycation activity on Trx1 and how this effects the ASK1 signaling pathway after I/R injury. Methods and Results: Initial studies found that DJ-1 deficient mice (DJ-1 KO) showed decreased levels of Trx1 activity after I/R injury compared to wild-type control mice. To explore a possible explanation for this decrease, we assessed the glycation of Trx1. Analysis revealed higher levels of carboxymethyl-lysine (CML) glycation of Trx1 in hearts of DJ-1 KO mice after I/R injury. This was accompanied by an increase in ASK1 phosphorylation and activity, as well as an increase in the phosphorylation of JNK, a downstream target of ASK1. To further determine if DJ-1 directly influences this signaling cascade, we employed an adenoviral approach (AAV9-CMV-DJΔc) to over-express the cleaved form of DJ-1. Compared to mice treated with a control virus, the overexpression of cleaved DJ-1 decreased the glycation of Trx1. Further, Trx1 activity was increased and ASK1 signaling was attenuated. Conclusion: These data suggest that the antiglycation activity of DJ-1 plays a role in preserving Trx1 activity after I/R injury. By expanding our perspective of how DJ-1 interacts with Trx1, these data bring us closer to uncovering a therapy that targets the ASK1 signaling pathway in the heart.
Engraftment of CLL-Derived T Cells in NSG Mice Is Feasible, Can Support CLL Cell Proliferation, and Eliminates the Need for Third Party Antigen Presenting Cells
Authors: Piers EM Patten, Shih-Shih Chen, Davide Bagnara, Rita Simone, Sonia Marsilio, Timothy Tong, Jaqueline C. Barrientos, Jonathan E. Kolitz, Steven L. Allen, Kanti R Rai, Nicholas Chiorazzi
Journal: Blood (2011)
Association Of Cardiac Iron By T2* With Innate Immune Markers In Transfusion-Dependent Thalassemia Patients Undergoing Combined Chelation Therapy
Authors: Patrick B Walter, Annie Higa, Vivian Ng, Marcela G Weyhmiller, Nick R Slater, Patricia Evans, John B Porter, Nancy Sweeters, Jackson Price, Alisha Manji, David Killilea, Ashutosh Lal, Elliott Vichinsky
Journal: Blood (2013)
The HACE1-NRF2 Axis a Novel Target in Acute Myeloid Leukemia
Authors: Andoni Garitano-Trojaola, Eva Teufel, Nadine Rodhes, Jennifer Kreckel, Thorsten Stuehmer, Matteo Claudio Da Via', Santiago Barrio Garcia, Torsten Haferlach, Raoul Tibes, Harald Wajant, Andreas Rosenwald, Hermann Einsele, K. Martin Kortüm
Journal: Blood (2018)
Improving biobehavioral outcomes with progressive muscle relaxation in patients with advanced lung cancer.
Authors: Nicole A Arrato, Stephen B. Lo, Madison Grogan, Nathan J. Stec, Christine Eastep, Kathryn M. Tenney, Sara A. Palmer, Barbara L. Andersen, Carolyn J Presley
Journal: Journal of Clinical Oncology (2019)

292 Background: Advanced lung cancer involves severe and distressing symptoms, especially anxiety, breathlessness, insomnia, and pain. Progressive muscle relaxation (PMR) is an empirically supported treatment for reducing stress and the emotional, cognitive, and physiological concomitants of anxiety. Methods: A quality improvement effort involved enhancing standard of care (SOC) by offering patients with newly diagnosed lung cancer one brief (20-minute) PMR session during a clinic visit for treatment determination. A static group comparison design was used. The PMR group ( n= 40) received PMR with pre (initial visit) and post (3-4 week follow-up) assessments of anxiety (Generalized Anxiety Disorder-7 Scale), breathlessness (American Thoracic Society for the Division of Lung Diseases Questionnaire), insomnia (Medical Outcomes Study Sleep Scale), and pain (Brief Pain Inventory). The static group ( n= 32) was assessed on one occasion only, during the 3-4 week follow-up visit. Pre/post analyses for the PMR group used paired samples t-tests. Linear regressions compared post data between the two groups. An alpha of .10 determined significance. Results: Analyses showed pre- to post-PMR differences in pain ( p= .036, d= .309) and breathlessness ( p= .084, d= .663), with null effects for anxiety ( p= .149, d= .178) and insomnia ( p= .811, d= .067). Controlling for performance status, smoking history, and toxicities, regression showed that the PMR group reported significantly less pain ( p= .046, b= 2.48). Conclusions: PMR effectively reduced symptoms of breathlessness and pain among patients with advanced lung cancer. Interventions based on the education and training of PMR may provide an improvement to SOC lung cancer treatment.
The Humanized Anti-CD40 Monoclonal Antibody, SGN-40, Potentiates Chemotherapy Regimens in NHL Xenograft Models Via Pro-Apoptotic Signaling.
Authors: Timothy S. Lewis, Renee S. McCormick, Kim Kissler, Ivan J. Stone, Mechthild Jonas, May S.K. Sutherland, Hans-Peter Gerber, Jonathan G. Drachman, Iqbal S. Grewal, Che-Leung Law
Journal: Blood (2007)
Chronic Lymphocytic Leukemia Shares a Common Cellular Origin with Regulatory B10 Cells
Authors: J. Brice Weinberg, David J. DiLillo, Yohei Iwata, Takashi Matushita, Karen M. Matta, Guglielmo M. Venturi, Giandomenico Russo, Youwei Chen, Jon P. Gockerman, Joseph O. Moore, Louis F. Diehl, Alicia D. Volkheimer, Daphne R. Friedman, Mark C Lanasa, Russell P. Hall, Thomas J. Tedder
Journal: Blood (2011)
Large outbreak of tularaemia, central Sweden, July to September 2019
Authors: Rikard Dryselius, Marika Hjertqvist, Signar Mäkitalo, Anders Lindblom, Tobias Lilja, Disa Eklöf, Anders Lindström
Journal: Eurosurveillance (2019)

On 31 of July 2019, the Public Health Agency of Sweden was alerted about an increasing number of tularaemia cases in Gävleborg, a county in central Sweden. The number of cases increased thereafter peaking at about 150 reports of illnesses every week. As at 6 October, a total of 979 cases (734 laboratory-confirmed) have been reported, mainly from counties in central Sweden. The outbreak is now considered over (as at 14 October).
Phase I/II trial of carbon-ion radiotherapy with concurrent gemcitabine for patients with locally advanced pancreatic cancer.
Authors: Makoto Shinoto, Shigeru Yamada, Shigeo Yasuda, Hiroshi Imada, Yoshiyuki Shioyama, Hiroshi Honda, Tadashi Kamada, Hirohiko Tsujii, Hiromitsu Saisho
Journal: Journal of Clinical Oncology (2013)

e15008 Background: Carbon-ion radiotherapy (CIRT) offers the potential advantage of improved dose localization and enhanced biologic effect. The purpose of this trial was to establish the recommended dose of gemcitabine and CIRT, evaluating the tolerance and efficacy of gemcitabine combined with CIRT for the treatment of the patients with locally advanced pancreatic cancer. Methods: Patients with histopathologically proven, locally advanced pancreatic adenocarcinoma, which involved the celiac trunk or superior mesenteric artery without distant metastasis, were eligible for this trial. The radiation fractions were fixed at 12 fractions in 3 weeks, and the dose of gemcitabine and radiation were gradually increased. First, the dose was fixed at 43.2GyE/8 fractions and the gemcitabine dose was increased from 400, to 700 to 1000mg/m 2 . Subsequently, the gemcitabine dose was fixed at 1000mg/m 2 and the radiation dose was increased from 43.2GyE to 55.2GyE by 5% increments. Gemcitabine was administered for 3 consecutive weeks, once a week. Results: Seventy-five patients were registered from April 2007 through February 2012. Of these patients, 71 were clinically eligible for the study. The most common Grade 3 acute toxicities were hematological toxicity (51%) and anorexia (8%). Dose limiting toxicity developed in three patients: Grade 3 gastric ulcer in 1 and Grade 4 leukopenia in 2. No other serious side effects were found. The two-year local control rate and two-year overall survival rate were 40% and 40% in all patients. The median survival time was 21 months. In the high dose group (n=47), in which patients were irradiated with at least 45.6 GyE, the two-year survival rate was 62%. Conclusions: CIRT was well tolerable even when concomitantly administered with the highest dose of gemcitabine (1000mg/m 2 ).
Management of septic arthritis
Authors: Anne-Cécile Debrach, Ilias Lazarou, Cem Gabay, Ilker Uçkay
Journal: JAMA (1982)

Native joint septic arthritis is a medical emergency requiring urgent joint drainage and antibiotic therapy. In the absence of an artificial joint or a foreign body, the « rheumatological approach » with repetitive arthrocentesis yields similar outcomes in the literature when compared to surgical drainage. Arthrocentesis could therefore be viewed as the preferential method of joint drainage as it is associated both with reduced morbidity for patients and decreased costs for the healthcare system. In case of failure with arthrocentesis, surgical arthroscopic drainage becomes necessary. In addition, the prescription of systemic steroids is promising but requires further studies, especially in adult patient populations.L’arthrite septique nécessite une prise en charge urgente, incluant le drainage articulaire et une antibiothérapie. En l’absence de prothèse ou de corps étrangers, les différents modes de drainage articulaire ont une efficacité similaire sur l’évolution clinique. L’approche rhumatologique avec arthrocentèse est la méthode la plus simple de drainage, associée à une morbidité et des coûts inférieurs aux techniques chirurgicales. Par conséquent, elle devrait être utilisée en premier lieu. En cas d’échec, l’arthroscopie, la méthode chirurgicale la moins invasive, pourra être considérée. La prescription d’une corticothérapie adjuvante semble prometteuse ; néanmoins, de plus amples études sont nécessaires chez l’adulte.
High-risk human papilloma virus testing in oropharyngeal squamous cell carcinoma at a university-based cancer center: A quality improvement project.
Authors: Deepthi Kodali, Melinda Sanders, Robert James Dowsett, Jeffrey Spiro, Upendra P. Hegde
Journal: Journal of Clinical Oncology (2019)

21 Background: Although traditionally linked to smoking and alcohol, high-risk (HR) human papilloma virus (HPV) associated head and neck cancers are becoming increasingly common in non-smokers. HR HPV causes approx. 70% of all oropharyngeal squamous cell carcinomas (OPSCC) and they have better outcomes when compared with smoking associated OPSCC. An accurate HPV assessment in OPSCC is important due to its relevance in treatment and follow up. This Quality Improvement project was designed to evaluate frequency of HPV testing with p16 immunochemistry (IHC) staining in patients with OPSCC at a University-based cancer center. Methods: All cases diagnosed with OPSCC or those with high suspicion for OPSCC between 2008 and 2017 were obtained from Department of Pathology. Patients with biopsies from sites other than oropharynx as well as those with biopsies performed at outside hospitals were excluded. All pathology reports were reviewed to identifyfrequency of p16 IHC staining. Results: A list of 127 cases was obtained from Pathology. Of these, 26 non-OPSCC and external hospital slides were excluded, making sample size (n) 101. HR HPV testing by p16 IHC staining was performed in 42 of 101 patients (41.5%) and not performed in 59 (58.5%). 38 of 42 patients tested were positive for HR HPV (90.5%). There was an overall upward trend in the frequency of HPV testing over the 10 years. Conclusions: HR HPV testing was done only in 41.5% of eligible patients suggesting a deficiency in testing for this biomarker. Various causes for this lack of testing were identified, most common one being inadequacy of tissue specimen. 90.5% of eligible patients tested were positive for HR-HPV, highlighting the strong association between HPV and OPSCC. Based on importance of testing HR HPV in OPSCC and need for aligning with American Society of Clinical Pathology guidelines, corrective actions were proposed by meeting with pathologists and otolaryngologists.
A Proinflammatory Invariant Natural Killer T Cells Phenotypic State Associates with Human Graft-Versus-Host Disease Onset and Response
Authors: Tom Erkers, Bryan Xei, Laura Kenyon, Mary Rieck, Marina Basina, Kent Jensen, Samuel Strober, Robert S. Negrin, Holden T. Maecker, Everett H Meyer
Journal: Blood (2018)
JAK2 Dependent GM-CSF Signaling Triggers SRSF2 Phosphorylation: A Potential Cause Of Mutation-Independent RNA Splicing Aberrancy In CMML
Authors: Sateesh Kunigal, Jamie Teer, Jeff Painter, Sean J Yoder, Euhnee Kim, Ling Zhang, Jeffrey E Lancet, Rami S. Komrokji, Omar Abdel-Wahab, Alan List, Pearlie K Epling-Burnette, Eric Padron
Journal: Blood (2013)
Lipid Management for the Prevention of Atherosclerotic Cardiovascular Disease
Authors: Erin D. Michos, John W. McEvoy, Roger S. Blumenthal
Journal: New England Journal of Medicine (2019)

Management of serum cholesterol level is a central objective in preventing cardiovascular events. Current guidelines recommend calculation of cardiovascular risk, with treatment decisions based on these data and clinician–patient discussion of risk. Statins remain the first line of pharmacotherapy.
Identification of Beta-Catenin As a Novel Ubiquitin-Regulated Target of Combined Flβ3/Syk- and Proteasome Inhibitors for Interruption of LSC Signaling in Poor-Risk AML
Authors: Sravanti Rangaraju, Silvia Marino, Daniela Nicoleta Petrusca, Larry D Cripe, Katie J Sargent, G. David Roodman, Hamid Sayar, Baskar Ramdas, Lakshmi Reddy Palam, Rajasubramaniam Shanmugam, Adriana Rogozea, Heiko Konig, Reuben Kapur, H. Scott Boswell
Journal: Blood (2018)
Association Of Graft Vs. Host Disease (GVHD) With a Lower Relapse/Progression Rate After Allogeneic Hemopoietic Stem Cell Transplantation (HSCT) With Reduced Intentsity Conditioning In Patients With Follicular and Mantle Cell Lymphoma: A Cibmtr Analysis
Authors: Alvaro Urbano-Ispizua, Steven Z. Pavletic, Mary E. D. Flowers, Mei-Jie Zhang, Jeanette Carreras, Sonali M. Smith, David G. Maloney, Silvia Montoto, Corey S. Cutler, Stephen R Spellman, Mukta Arora, Wael Saber
Journal: Blood (2013)
Abstract 835: Development of Molecular Targeted Therapy Against Right Ventricular Failure: Evaluation by Transcriptome and <i>i</i> n vivo Analysis
Authors: Shogo Ito, Shinsuke Yuasa, Jin Komuro, Toshiomi Katsuki, Mai Kimura, Yoshikazu Kishino, Dai Kusumoto, Hisayuki Hashimoto, Yoshihiro Fukumoto, Keiichi Fukuda
Journal: Circulation Research (2019)

Backgrounds: Right ventricular (RV) failure is a final common pathway in heart failure. But there is no specific therapy for RV failure. Moreover, it remains unclear how RV failure is developed. To develop a novel therapy for RV failure, we focused on the RV specific character and elucidate the function in RV failure. Methods: Microarray analysis using several parts of adult murine heart was conducted and differentially expressed genes (DEGs) were applied to pathway analysis. Molecular mechanism was examined by using rat cardiomyocytes in vitro. To understand the function of target molecule in vivo, we induced RV failure by pulmonary artery constriction (PAC) in mice and the pathway was specifically blocked in the RV failure model. Results: In microarray analysis for upper RV, RV free wall, LV and ventricular septum, 995 genes were statistically extracted as DEG in upper RV. An alternative complement pathway was significantly activated in upper RV and complement factor, and C3a was a potential upstream factor attributable to unique feature of upper RV. Because C3a plays a central role in alternative complement pathway, we examined the direct role of C3a in cardiomyocytes and RV function. Administration of C3a recombinant protein to primary-cultured cardiomyocytes activated the several MAP kinases including ERK, p38 and JNK, via C3a receptor. Mice developed severe RV failure around 14 days after PAC. Surprisingly, administration of C3a receptor antagonist dramatically improved right ventricular contractile dysfunction in PAC mice. C3 (substrate of C3a) deficient PAC mice also attenuated RV contractile dysfunction, fibrotic change and fetal gene expressions. There results indicated that complement factor C3a regulates the unique phenotypes in RV. Chemical or genetical blockade of C3a ameliorates RV dysfunction in PAC mice. Conclusion: We revealed that alternative complement pathway was activated in RV and C3a had a crucial role in the pathogenesis of RV failure. Accordingly, the blockade of C3a pathway would be a potential therapeutic target for RV disorders.
Early Febrile Infection after Allogeneic Stem Cell Transplantation of Acute Leukemia Is Associated with a Reduced Risk of Leukemic Relapse.
Authors: Sung-Yong Kim, Chang-Ki Min, Byung-Sik Cho, Ki-Seong Eom, Yoo-Jin Kim, Seok Lee, Hee-Je Kim, Seok-Goo Cho, Dong-Wook Kim, Jong-Wook Lee, Woo-Sung Min, Chun-Choo Kim
Journal: Blood (2007)
Physically active lessons in schools and their impact on physical activity, educational, health and cognition outcomes: a systematic review and meta-analysis
Authors: Emma Norris, Tommy van Steen, Artur Direito, Emmanuel Stamatakis
Journal: British Journal of Sports Medicine (2019)

Objective This review provides the first meta-analysis of the impact of physically active lessons on lesson-time and overall physical activity (PA), as well as health, cognition and educational outcomes. Design Systematic review and meta-analysis of controlled studies. Six meta-analyses pooled effects on lesson-time PA, overall PA, in-class educational and overall educational outcomes, cognition and health outcomes. Meta-analyses were conducted using the metafor package in R. Risk of bias was assessed using the Cochrane tool for risk of bias. Data sources PubMed, Embase, PsycINFO, ERIC and Web of Science, grey literature and reference lists were searched in December 2017 and April 2019. Studies eligibility criteria Physically active lessons compared with a control group in a randomised or non-randomised design, within single component interventions in general school populations. Results 42 studies (39 in preschool or elementary school settings, 27 randomised controlled trials) were eligible to be included in the systematic review and 37 of them were included across the six meta-analyses (n=12 663). Physically active lessons were found to produce large, significant increases in lesson-time PA ( d =2.33; 95% CI 1.42 to 3.25: k =16) and small, increases on overall PA ( d =0.32; 95% CI 0.18 to 0.46: k =8), large, improvement in lesson-time educational outcomes ( d =0.81; 95% CI 0.47 to 1.14: k =7) and a small improvement in overall educational outcomes ( d =0.36; 95% CI 0.09 to 0.63: k =25). No effects were seen on cognitive (k=3) or health outcomes (k=3). 25/42 studies had high risk of bias in at least two domains. Conclusion In elementary and preschool settings, when physically active lessons were added into the curriculum they had positive impact on both physical activity and educational outcomes. These findings support policy initiatives encouraging the incorporation of physically active lessons into teaching in elementary and preschool setting. Trial registration number CRD42017076933.
Everyone needs robust analytics: Integrating medical ontologies into the Dana-Farber Pathways.
Authors: Dana Milne, Joanna M. Hamilton, Debra McNeil, John Methot, Joseph O. Jacobson, Carole Kathleen Tremonti, David Michael Jackman
Journal: Journal of Clinical Oncology (2019)

304 Background: The majority of clinical data is unstructured. Medical ontologies standardize the language used to communicate diagnoses, symptoms, and procedures used in healthcare. Incorporating medical ontologies into the Dana-Farber Pathways (DFP) provides structure and removes ambiguity by creating definitions for each data point. This exercise was critical for the development of the DFP into a fully automated platform that optimizes clinician workflow, reduces clicks, and expands the potential for data analysis. Methods: The DFP data model was reviewed to identify value sets contained in an existing medical ontology. DFP required employing multiple ontologies, which was difficult, as many ontologies overlap (e.g., SNOMED, NCI, ICD-O-3, ICD-10) and none were developed for this intention. For example, the majority of DFP necessitate site/histology as a criterion for decision-making. In our Electronic Data Warehouse (EDW), site/histology are stored as free text, as ICD-O-3 codes from the cancer registry, and as ICD-10 codes from Epic. To obtain site/histology in a structured format, both ICD-O-3 and ICD-10 were needed. Ongoing maintenance of the linkages between ontologies and value sets is required as ontologies are updated and DFP are enhanced. Results: The relationship between the DFP value set and the SNOMED ontology was 1:1. However, other relationships were not equal or straightforward. Some ontology values were too detailed for DFP. These were either grouped together (e.g. tumor site) or just one value was chosen (e.g. drug class). Others didn’t contain all the values required by DFP (e.g. regimens). Conclusions: DFP requires structured data related to ontologies but not identical to and not limited by the scope of ontologies. Choosing medical ontologies utilized in an EDW facilitates the implementation of auto-navigation, which ultimately streamlines provider workflow. A structured data model connected to ontologies collects valid and clearly defined data to support robust analytics. [Table: see text]
Factor VIII Structure, Not Activity, Is the Primary Determinant of Immunogenicity in Hemophilia A and Combined Hemophilia A/Von Willebrand Disease Mice
Authors: Shannon L. Meeks, Courtney Cox, John F. Healey, Ernest T Parker, Bagirath Gangadharan, Rachel T. Barrow, John (Pete) S. Lollar
Journal: Blood (2011)
Association of Psoriasis With the Risk of Developing or Dying of Cancer
Authors: Alex M. Trafford, Rosa Parisi, Evangelos Kontopantelis, Christopher E. M. Griffiths, Darren M. Ashcroft
Journal: JAMA Dermatology (2019)

The risk of cancer developing in people with psoriasis has raised some concern, with little clarity regarding differentiation in risk according to psoriasis severity.
Compared the Effect of Mitroxantrone ( MA) with Idarubicine (IA) for Acute Myeloid Leukemia Induction Therapy
Authors: Peilong Lai, Mingyan Wu, Minming Li, Chengxin Deng, Zesheng Lu, Chenwei Luo, Xin Huang, Pengjun Liao, Lisi Huang, Ping Wu, Wang Yulian, Changchun Wan, Wei Ling, Liye Zhong, Suijing Wu, Xin Du, Jianyu Weng
Journal: Blood (2018)