tbuckley/cabot-search huggingface dataset:
Abstract 14335: Predictors of Hospital Readmission in Patients With Critical Limb Ischemia Treated With Endovascular Therapy
Authors: Pejman Raeisi-Giglou, Grant W Reed, Negar Salehi, Umair Malik, Rami Kafa, Michael Maier, Mehdi H Shishehbor
Journal: Circulation (2015)

Introduction: Patients with critical limb ischemia (CLI) are at high risk for hospital readmission after endovascular therapy. Identifying predictors of readmission and understanding the prognosis of patients readmitted may improve outcomes. Methods: In this prospective study of 252 patients with CLI after endovascular therapy, predictors of readmission were determined by Cox proportional hazards analysis. Readmission was stratified by wound status (no wound, wound present but healed by readmission, and persistent wound). The incidence of major adverse limb events (MALE; major amputation, endartectomy, or surgical bypass) was compared in patients readmitted and not readmitted via Kaplan-Meier analysis. Results: During a median follow-up of 381 days (interquartile range [IQR], 115-718 days), 140 (56%) patients were readmitted. Median days to readmission was 83 (IQR 33-190 days). Independent predictors of readmission are shown in the Table. When analyzed as a time-dependent covariate, wound healing was associated with less risk of readmission (Hazard Ratio 0.39; 95% Confidence Interval 0.22-0.68; p&lt;0.001). Readmission was most frequent in patients with unhealed wounds, and those with healed wounds were less likely to be readmitted than those without wounds (Figure A). MALE was more common in patients readmitted (Figure B). Conclusions: Patients with CLI and unhealed wounds are at increased risk of readmission after endovascular therapy. Other independent predictors of readmission include presence of multiple wounds, age ≥ 70 years, male gender, history of heart failure, dialysis dependence, and lack of aspirin use. Readmission is associated with increased MALE.
Abstract 16606: Cardiac Fibroblast-Restricted Enhancement of G <sub>q</sub> Signaling Prolongs Calcium Transients and Increases Spontaneous Activity in Biomimetic Cardiac Microtissues
Authors: Celinda M Kofron, Tae Yun Kim, Michelle E King, Elizabeth M Park, Bum-Rak Choi, Ulrike Mende
Journal: Circulation (2014)

Introduction: Enhanced G q signaling in response to hemodynamic stress and injury is well known to induce remodeling in both cardiac myocytes (CMs) and fibroblasts (CFs). However, the effect of CF activation and fibrosis on CMs and integrated myocardial function cannot be easily discerned from concomitant effects on CMs. Hypothesis: Enhanced G q signaling in CFs influences CM function in a 3D microtissue model previously developed in our lab, in which neonatal rat ventricular CMs and CFs are highly interspersed as seen in the myocardium. Methods: CFs infected in suspension (2 hrs, 10 MOI) with empty adenovirus (Ad-Ctr) or Ad encoding wild-type (WT) or constitutively active (Q209L or QL) Gα q were co-seeded with uninfected CMs (CM:CF 1:1) into non-adhesive hydrogels at ~1200 cells per recess (400/800 μm wide/deep). After 2-4 days, we assessed tissue size by microscopy, G q and extracellular matrix proteins proteins by Western Blot analysis, and Ca 2+ transients ([Ca 2+ ] i ) with Rhod 2/AM. Results: Overexpression of Gα q in CFs was associated with a 3-fold (WT) and 7-fold (QL) increase in total inositolphosphate formation, indicating enhanced basal phospholipase β activity. After 4 days, CM:CF QL tissues were larger in size by 30-40% and expressed more laminin and fibronectin. After 3 days, CM:CF CTR paced at 1 Hz had [Ca 2+ ] i duration of 218±3 ms, decay of 141±2 ms, and rise time of 35±4 ms (n=55-69). In CM:CF QL , duration and decay were prolonged by 160 ms and 21 ms, resp., and rise time was decreased by 5 ms (n=10-27). In CM:CF WT with less G q signaling, [Ca 2+ ] i duration and decay were also prolonged but only by 30 ms and 7 ms, resp. (n=46-51). These effects were similar but less pronounced after 2 days and/or at 2 Hz. Spontaneous [Ca 2+ ] i activity was seen in 50% of CM:CF QL , 11% of CM:CF WT , but only 2% of CM:CF CTR microtissues. The gap junction inhibitor carbenoxolone (100 μM) decreased this activity in CM:CF QL by 80% and in CM:CF WT by 15%. Conclusion: We show that enhanced CF-restricted G q signaling in biomimetic cardiac microtissues increases tissue size, prolongs [Ca 2+ ] i duration and decay, and increases spontaneous Ca 2+ activity. Our findings suggest that depending on the CF activation state, CFs can greatly modulate CM calcium handling and potentially influence arrhythmogenesis.
Inter‐ and intrarater reliability of Hurley staging for hidradenitis suppurativa
Authors: Z.N. Ovadja, M.M. Schuit, C.M.A.M. Horst, O. Lapid
Journal: British Journal of Dermatology (2018)

Hidradenitis suppurativa (HS) is a chronic, inflammatory and recurrent skin disease. Different staging instruments have been suggested, but none has achieved universal acceptance. Despite the fact that Hurley staging is one of the most widely applied HS disease severity staging instruments, it has not been validated. To determine the inter‐ and intrarater reliability of the Hurley staging system. Fifteen raters (five plastic surgeons, five general surgeons and five dermatologists) independently staged 30 photos of patients with HS according to Hurley staging at two time points. Reliability was assessed using kappa (&kgr;) statistics, and multivariable logistic regressions were used to determine independent risk factors for photos with discordant staging. Inter‐rater reliability was moderate for the three stages of HS [κ = 0·59, 95% confidence interval (CI) 0·48–0·70]. It was moderate for Hurley stage I (κ = 0·45, 95% CI 0·32–0·55) and stage II (κ = 0·51, 95% CI 0·31–0·71) and it was almost perfect for stage III (κ = 0·81, 95% CI 0·62–1·00). The intrarater reliability was substantial for all stages and all raters (κ = 0·65, 95% CI 0·58–0·72). For stage I it was moderate (κ = 0·50, 95% CI 0·38–0·62), for stage II it was substantial (κ = 0·62, 95% CI 0·51–0·73) and for stage III it was almost perfect (κ = 0·82, 95% CI 0·77–0·87). Hurley stages II and III were less likely to result in discordant staging than Hurley stage I (odds ratios 0·47, 95% CI 0·29–0·77 and 0·21, 95% CI 0·12–0·38, respectively). The mean time spent on staging a photo was 14 s. Hurley staging is reliable for rapid severity assessment of HS, with moderate inter‐rater and substantial intrarater reliability for all stages. It is best for assessing Hurley stage III HS, which is an indication for surgery.
Abstract 19258: Depression and Psychosis are Associated With Shorter Length of Hospital Stay in Patients With Stress (Takotsubo) Cardiomyopathy: A Nationwide Analysis of 2014
Authors: Bing Yue, Shuyang Fang, Chayakrit Krittanawong, Xin Wei, Mariam Khandaker, Eyal Herzog
Journal: Circulation (2017)

Introduction: Stress (Takotsubo) cardiomyopathy has been increasingly recognized around the world. Studies have showed that patients with certain psychiatric comorbidities, including depression and...
Epigenetic Drug Screen on Resistant CLL Cells Reveals Aurora Kinase Inhibitors As Enhancers of CD20 Expression and Sensitizers to Treatment with CD20 Monoclonal Antibodies
Authors: Veronika Kozlova, Aneta Ledererova, Michael Doubek, Jiri Mayer, Sarka Pospisilova, Michal Smida
Journal: Blood (2018)
The Biology of m6A RNA Methylation in Normal and Malignant Hematopoiesis
Authors: Ly P. Vu, Yuanming Cheng, Michael G. Kharas
Journal: Cancer Discovery (2018)

Abstract Hematopoietic development and differentiation are highly regulated processes, and recent studies focusing on m6A mRNA methylation have uncovered how this mark controls cell fate in both normal and malignant hematopoietic states. In this review, we focus on how writers, readers, and erasers of RNA methylation can mediate distinct phenotypes on mRNAs and on cells. Targeting the RNA methylation program has emerged as a potential novel therapeutic strategy, and we explore the role for these regulators in both normal and dysregulated cell contexts. Significance: RNA methylation is required for cancer cell survival in solid tumors and in acute myeloid leukemia, and targeting this pathway has been proposed as a new therapeutic strategy in cancer. However, understanding the role for RNA methylation in both normal and malignant states is essential for understanding the potential consequences for therapeutic intervention.
Social Determinants of Health in the Digital Age
Authors: Freddy Abnousi, John S. Rumsfeld, Harlan M. Krumholz
Journal: JAMA (2018)

In this Viewpoint, Harlan Krumholz and colleagues discuss the promise that social media data hold for helping researchers better understand social determinants of health, and the challenges that must be overcome to reliably link social network data to clinical and health outcomes.
Inhibition of Mevalonate Pathway Prevents Adipocyte Browning in Mice and Men by Affecting Protein Prenylation
Authors: Miroslav Balaz, Anton S. Becker, Lucia Balazova, Leon Straub, Julian Müller, Gani Gashi, Claudia Irene Maushart, Wenfei Sun, Hua Dong, Caroline Moser, Carla Horvath, Vissarion Efthymiou, Yael Rachamin, Salvatore Modica, Caroline Zellweger, Sara Bacanovic, Patrik Stefanicka, Lukas Varga, Barbara Ukropcova, Milan Profant, Lennart Opitz, Ez-Zoubir Amri, Murali K. Akula, Martin Bergo, Jozef Ukropec, Christian Falk, Nicola Zamboni, Matthias Johannes Betz, Irene A. Burger, Christian Wolfrum
Journal: Cell Metabolism (2018)
Abstract 15068: Differential Impact of BNP and NTproBNP on Cardiovascular Outcomes in Obese and Non-Obese Japanese Populations: The J-HOP Study
Authors: Hirotaka Waki, Satoshi Hoshide, Yusuke Ishiyama, Mizuri Taki, Hiroyuki Mizuno, Takahiro Komori, Ken Kono, Kazuomi Kario
Journal: Circulation (2017)

Introduction: Obesity may affect brain natriuretic peptide (BNP) and N-terminal proBNP (NTproBNP) levels, and differences in their biological characteristics may provide differential prognostic per...
A systematic review of comorbidities and outcomes of adult patients with pleural infection
Authors: Tamsin N. Cargill, Maged Hassan, John P. Corcoran, Elinor Harriss, Rachelle Asciak, Rachel M. Mercer, David J. McCracken, Eihab O. Bedawi, Najib M. Rahman
Journal: European Respiratory Journal (2019)

Background Pleural infection remains an important cause of mortality. This study aimed to investigate worldwide patterns of pre-existing comorbidities and clinical outcomes of patients with pleural infection. Methods Studies reporting on adults with pleural infection between 2000 and 2017 were identified from a search of Embase and MEDLINE. Articles reporting exclusively on tuberculous, fungal or post-pneumonectomy infection were excluded. Two reviewers assessed 20 980 records for eligibility. Results 211 studies met the inclusion criteria. 134 articles (227 898 patients, mean age 52.8 years) reported comorbidity and/or outcome data. The majority of studies were retrospective observational cohorts (n=104, 78%) and the most common region of reporting was East Asia (n=33, 24%) followed by North America (n=27, 20%). 85 articles (50 756 patients) reported comorbidity. The median (interquartile range (IQR)) percentage prevalence of any comorbidity was 72% (58–83%), with respiratory illness (20%, 16–32%) and cardiac illness (19%, 15–27%) most commonly reported. 125 papers (192 298 patients) reported outcome data. The median (IQR) length of stay was 19 days (13–27 days) and median in-hospital or 30-day mortality was 4% (IQR 1–11%). In regions with high-income economies (n=100, 74%) patients were older (mean 56.5 versus 42.5 years, p&lt;0.0001), but there were no significant differences in prevalence of pre-existing comorbidity nor in length of hospital stay or mortality. Conclusion Patients with pleural infection have high levels of comorbidity and long hospital stays. Most reported data are from high-income economy settings. Data from lower-income regions is needed to better understand regional trends and enable optimal resource provision going forward.
Abstract 17972: Isolated Non-Specific ST-Segment and T-Wave Abnormalities on Screening Electrocardiogram is Associated With Incident Stroke Risk in the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study
Authors: Mitsuaki Sawano, Ya Yuan, Shun Kohsaka, Taku Inohara, Takeki Suzuki, Tomonori Okamura, George Howard, Virgnia Howard, Suzanne Judd, Elsayed Z Soliman, Mary Cushman
Journal: Circulation (2016)

Introduction: Prior reports have shown that isolated non-specific ST-segment and T-wave abnormalities (NSSTTAs), a common finding on electrocardiograms (ECGs), are associated with a greater risk fo...
Infographic. Thermoregulatory impairment in athletes with a spinal cord injury
Authors: Katy Ellen Griggs, George Havenith, Michael J Price, Victoria L Goosey-Tolfrey
Journal: British Journal of Sports Medicine (2019)

Presented in this infographic is a summary of studies investigating the thermoregulatory impairment of athletes with a spinal cord injury (SCI) during real-world sporting scenarios. [1]2][3] The infographic depicts the heightened thermal strain experienced by athletes with tetraplegia (high-level lesions), both compared with athletes with paraplegia (low-level lesions) and within the sport of wheelchair rugby.In addition to the cooling interventions presented, the infographic highlights the significant need for appropriate interventions to reduce the risk of overheating and potential performance decrements. 4 This infographic was field tested with those who work within a wheelchair sports environment, ranging from practitioners, researchers, athletes with an SCI and sports clinicians.The experimental studies were also designed in consultation with the wheelchair rugby coaches and players.
Situs Inversus With Dextrocardia and Transposition Of Great Arteries From Diagnosis to Management
Authors: Neeraj Awasthy, Swati Kapoor, Rajeev Upreti, Kulbhushan Dagar
Journal: Clinical Cardiology and Cardiovascular Interventions (2018)

Situs inversus totalis is a rare anomaly. A 40 day old girl presented to our emergency with this condition. She also had intact ventricular septum and D-transposition of the great arteries. Balloon atrial septostomy is usually a lifesaving procedure in such patients, till the corrective surgery is performed. In our case, this procedure was performed in the patient and we discuss the implication of her abnormal anatomy in the ease of management of this case. To our knowledge, this is the first case report of such a procedure in a patient with this unusual presentation.
The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum
Authors: Sonal Srikanth, Jin Seok Woo, Beibei Wu, Yasser M. El-Sherbiny, Jennifer Leung, Koollawat Chupradit, Laura Rice, Gil Ju Seo, Guillaume Calmettes, Chandran Ramakrishna, Edouard Cantin, Dong Sung An, Ren Sun, Ting-Ting Wu, Jae U. Jung, Sinisa Savic, Yousang Gwack
Journal: Nature Immunology (2018)
The frequency of intrapartum caesarean section use with the WHO partograph versus Zhang's guideline in the Labour Progression Study (LaPS): a multicentre, cluster-randomised controlled trial
Authors: Stine Bernitz, Rebecka Dalbye, Jun Zhang, Torbjørn M Eggebø, Kathrine F Frøslie, Inge Christoffer Olsen, Ellen Blix, Pål Øian
Journal: The Lancet (2018)
Challenges in interpreting trends in testing for α<sub>1</sub>-antitrypsin deficiency in COPD patients from UK primary care
Authors: Joan B. Soriano
Journal: European Respiratory Journal (2018)

<b>It is still necessary to explore the recording of α<sub>1</sub>-antitrypsin deficiency testing (and diagnosis) in other large primary care populations and datasets</b>http://ow.ly/PANZ30mIvw7
Abstract 18: Analyzing Heart Rhythm During Chest Compressions in Out-of-Hospital Cardiac Arrest Patients Using New Algorithm for Automated External Defibrillators
Authors: Corina de Graaf, Stefanie G Beesems, Ronald E Stickney, Paula Lank, Fred W Chapman, Rudolph W Koster
Journal: Circulation (2018)

Purpose: Automated external defibrillators (AED) prompt the rescuer to stop cardiopulmonary resuscitation (CPR) for ECG analysis. Any interruption of CPR has a negative impact on outcome. We prospectively evaluated a new algorithm (cprINSIGHT) which can analyse the ECG while rescuers continue CPR. Methods: We analysed data from patients with attempted resuscitation from OHCA who were connected to an AED with cprINSIGHT (Stryker Physio-Control LIFEPAK CR2) between June 2017 and June 2018 in the Amsterdam Resuscitation Study region. The first analysis in the CR2 is a conventional analysis; subsequent analyses use the cprINSIGHT algorithm. This algorithm classifies the rhythm as shockable (S), non-shockable (NS), or no decision. If no decision, the AED prompts for a pause in CPR and uses its conventional algorithm. The characteristics of the first 3 cprINSIGHT analyses (analyses 2-4) were analysed. Ventricular fibrillation (VF) cases were both coarse and fine VF with a lower threshold of 0.08 mV. Results: Data from 132 consecutive OHCA cases were analysed. The initial recorded rhythm was VF or pulseless ventricular tachycardia (VT) in 35 cases (27%), pulseless electrical activity in 34 cases (25%) and asystole in 63 cases (48%). In 114 cases (86%), 1 or more cprINSIGHT analyses were done. Analyses 2-4 covered 90% of all cprINSIGHT analyses. The analyzed rhythm was VF/VT in 12-17%, organised QRS rhythm in 29-35% and asystole in 51-56% (see table). cprINSIGHT reached a S or NS decision in 65-74% of cases, with a sensitivity of 90-100% and a specificity of 100%. When it reached no decision, the rhythm was asystole in 65-79% of analyses, VF/VT in 0-9% and QRS rhythm in 18-27%; conventional analysis followed. Chest compression fraction was 85-88%, CPR fraction was 99%. Conclusion: This new algorithm analysed the ECG without need for a pause in chest compressions 65-74% of the time and had 90-100% sensitivity and 100% specificity when it made a shock or a no shock decision.
Clinical and Genomic Implications of Luminal and Basal Subtypes Across Carcinomas
Authors: Shuang G. Zhao, William S. Chen, Rajdeep Das, S. Laura Chang, Scott A. Tomlins, Jonathan Chou, David A. Quigley, Ha X. Dang, Travis J. Barnard, Brandon A. Mahal, Ewan A. Gibb, Yang Liu, Elai Davicioni, Linda R. Duska, Edwin M. Posadas, Shruti Jolly, Daniel E. Spratt, Paul L. Nguyen, Christopher A. Maher, Eric J. Small, Felix Y. Feng
Journal: Clinical Cancer Research (2018)

Abstract Purpose: Carcinomas originate from epithelial tissues, which have apical (luminal) and basal orientations. The degree of luminal versus basal differentiation in cancer has been shown to be biologically important in some carcinomas and impacts treatment response. Experimental Design: Although prior studies have focused on individual cancer types, we used a modified clinical-grade classifier (PAM50) to subtype 8,764 tumors across 22 different carcinomas into luminal A, luminal B, and basal-like tumors. Results: We found that all epithelial tumors demonstrated similar gene expression–based luminal/basal subtypes. As expected, basal-like tumors were associated with increased expression of the basal markers KRT5/6 and KRT14, and luminal-like tumors were associated with increased expression of the luminal markers KRT20. Luminal A tumors consistently had improved outcomes compared with basal across many tumor types, with luminal B tumors falling between the two. Basal tumors had the highest rates of TP53 and RB1 mutations and copy number loss. Luminal breast, cervical, ovarian, and endometrial tumors had increased ESR1 expression, and luminal prostate, breast, cervical, and bladder tumors had increased androgen receptor (AR) expression. Furthermore, luminal B tumors had the highest rates of AR and ESR1 mutations and had increased sensitivity in vitro to bicalutamide and tamoxifen. Luminal B tumors were more sensitive to gemcitabine, and basal tumors were more sensitive to docetaxel. Conclusions: This first pan-carcinoma luminal/basal subtyping across epithelial tumors reveals global similarities across carcinomas in the transcriptome, genome, clinical outcomes, and drug sensitivity, emphasizing the biological and translational importance of these luminal versus basal subtypes.
Pulmonary rehabilitation in bronchiectasis: a propensity-matched study
Authors: Suhani Patel, Aaron D. Cole, Claire M. Nolan, Ruth E. Barker, Sarah E. Jones, Samantha Kon, Julius Cairn, Michael Loebinger, Robert Wilson, William D-C. Man
Journal: European Respiratory Journal (2018)

International guidelines recommend pulmonary rehabilitation for patients with bronchiectasis, supported by small trials and data extrapolated from chronic obstructive pulmonary disease (COPD). However, it is unknown whether real-life data on completion rates and response to pulmonary rehabilitation are similar between patients with bronchiectasis and COPD. Using propensity score matching, 213 consecutive patients with bronchiectasis referred for a supervised pulmonary rehabilitation programme were matched 1:1 with a control group of 213 patients with COPD. Completion rates, change in incremental shuttle walk (ISW) distance and change in Chronic Respiratory Disease Questionnaire (CRQ) score with pulmonary rehabilitation were compared between groups. Completion rate was the same in both groups (74%). Improvements in ISW distance and most domains of the CRQ with pulmonary rehabilitation were similar between the bronchiectasis and COPD groups (ISW distance: 70 versus 63 m; CRQ-Dyspnoea: 4.8 versus 5.3; CRQ-Emotional Function: 3.5 versus 4.6; CRQ-Mastery: 2.3 versus 2.9; all p&gt;0.20). However, improvements in CRQ-Fatigue with pulmonary rehabilitation were greater in the COPD group (bronchiectasis 2.1 versus COPD 3.3; p=0.02). In a real-life, propensity-matched control study, patients with bronchiectasis show similar completion rates and improvements in exercise and health status outcomes as patients with COPD. This supports the routine clinical provision of pulmonary rehabilitation to patients with bronchiectasis.
Role of Screening History in Clinical Meaning and Optimal Management of Positive Cervical Screening Results
Authors: Philip E Castle, Walter K Kinney, Xiaonan Xue, Li C Cheung, Julia C Gage, Nancy E Poitras, Thomas S Lorey, Hormuzd A Katki, Nicolas Wentzensen, Mark Schiffman
Journal: JNCI Journal of the National Cancer Institute (2018)

Cervical cancer is caused by persistent human papillomavirus (HPV) infection. US consensus management guidelines for a positive cervical screening result typically focus on the current screening result only. A negative testing history may alter risk of the following positive screening results, caused by a new HPV infection, and therefore its optimal management.