tbuckley/cabot-search huggingface dataset:
Long-Term Adverse Cardiac Outcomes in Patients With Sarcoidosis
Authors: Adelina Yafasova, Emil L. Fosbøl, Morten Schou, Finn Gustafsson, Kasper Rossing, Henning Bundgaard, Marie D. Lauridsen, Søren L. Kristensen, Christian Torp-Pedersen, Gunnar H. Gislason, Lars Køber, Jawad H. Butt
Journal: Journal of the American College of Cardiology (2020)
Alzheimer disease beta-amyloid activity mimics cholesterol oxidase (vol 116, pg 2828, 2006)
Authors: Luigi Puglielli, Avi L Friedlich, Kenneth Dr Setchell, Seiichi Nagano, Carlos Opazo, Robert A Cherny, Kevin J Barnham, John D Wade, Simon Melov, Dora M Kovacs, Ashley I Bush
Journal: Journal of Clinical Investigation (2006)
Response to ‘The incidence and survival of melanoma and nonmelanoma skin cancer in patients with vitiligo: a nationwide population‐based matched cohort study in Korea’ – reply from the authors
Authors: H.S. Kim, H.S. Ahn
Journal: British Journal of Dermatology (2020)

Linked Articles: Choi and Lee. Br J Dermatol 2020; 183:1149–1150; Kim et al. Br J Dermatol 2020; 182:907–915.
BREACH OF AUTOREACTIVE B-CELL TOLERANCE BY
Authors: J. Dekkers, M. Verheul, J. Stoop, B. Liu, A. Ioan-Facsinay, P. van Veelen, A. de Ru, G. Janssen, M. Hegen, S. Rapecki, T. Huizinga, L. Trouw, R. Toes
Journal: Annals of the Rheumatic Diseases (2017)
Oestrogen-mediated upregulation of the Mas receptor contributes to sex differences in acute lung injury and lung vascular barrier regulation
Authors: Lasti Erfinanda, Krishnan Ravindran, Franziska Kohse, Kathleen Gallo, Robert Preissner, Thomas Walther, Wolfgang M. Kuebler
Journal: European Respiratory Journal (2020)

Epidemiological data from the SARS-CoV-2 outbreak suggest sex differences in mortality and vulnerability; however, sex-dependent incidence of acute respiratory distress syndrome (ARDS) remains controversial and the sex-dependent mechanisms of endothelial barrier regulation are unknown. In premenopausal women, increased signalling of angiotensin (Ang)(1-7) via the Mas receptor has been linked to lower cardiovascular risk. Since stimulation of the Ang(1-7)/Mas axis protects the endothelial barrier in acute lung injury (ALI), we hypothesised that increased Ang(1-7)/Mas signalling may protect females over males in ALI/ARDS.Clinical data were collected from Charité inpatients (Berlin) and sex differences in ALI were assessed in wild-type (WT) and Mas-receptor deficient (Mas-/- ) mice. Endothelial permeability was assessed as weight change in isolated lungs and as transendothelial electrical resistance (TEER) in vitroIn 734 090 Charité inpatients (2005-2016), ARDS had a higher incidence in men as compared to women. In murine ALI, male WT mice had more lung oedema, protein leaks and histological evidence of injury than female WT mice. Lung weight change in response to platelet-activating factor (PAF) was more pronounced in male WT and female Mas-/- mice than in female WT mice, whereas Mas-receptor expression was higher in female WT lungs. Ovariectomy attenuated protection in female WT mice and reduced Mas-receptor expression. Oestrogen increased Mas-receptor expression and attenuated endothelial leakage in response to thrombin in vitro This effect was alleviated by Mas-receptor blockade.Improved lung endothelial barrier function protects female mice from ALI-induced lung oedema. This effect is partially mediated via enhanced Ang(1-7)/Mas signalling as a result of oestrogen-dependent Mas expression.
The influx/efflux mechanisms of d-peptide ligand of nAChRs across the blood–brain barrier and its therapeutic value in treating glioma
Authors: Bing Han, Weiyi Xie, Yanxia Zhang, Shilin Zhou, Jiahong Yang, Ruifeng Wang, Yuqing Sun, Xiaoyi Wang, Jie Xu, Dawei Chen, Yinhang Wang, Jiasheng Lu, Fengling Ning, Fuming Shen, Min Liu, Hui Cai, Hong Xin, Weiyue Lu, Xuemei Zhang
Journal: Journal of Controlled Release (2020)
Covid-19 misinformation sparks threats and violence against doctors in Latin America
Authors: Luke Taylor
Journal: BMJ (2020)

<h3>Background</h3> Although Egypt places four generic pictorial health warnings (PHWs) on the front and back half of waterpipe tobacco packs (WTPs), waterpipe tobacco smoking (WTS) rates have continued to rise. It has been suggested that PHWs would be more salient if placed on the waterpipe device itself. This qualitative study explored how participants perceived the effects placing PHWs on waterpipe devices would have on warning salience and uptake or quitting of WTS. <h3>Methods</h3> We conducted 10 focus groups and 10 in-depth interviews with 90 adult waterpipe smokers and non-smokers, men and women, who lived in rural, semi-urban and urban regions of Egypt. We presented participants with four novel PHWs of different sizes positioned randomly at four locations on a waterpipe device (the glass body, metal holder, mouthpiece or hose), one at a time. At each session, participants viewed a PHW on all four locations. Novel warnings were shown on plain labels with a dark uniform background and featured pictures, text and the quitline number. Transcripts were analysed using thematic analysis. <h3>Results</h3> Participants thought placing PHWs on waterpipe devices might increase salience, prevent WTS initiation or trigger quit attempts; they favoured placing PHWs on the glass body, mouthpiece or waterpipe hose. Both waterpipe smoker and non-smoker participants thought these potential effects would affect non-smokers or non-established smokers more than established waterpipe users. <h3>Conclusions</h3> Our exploratory study suggests that PHWs featured prominently on waterpipe devices could potentially deter experimentation with waterpipe tobacco products and promote cessation, especially among non-established users.
Germline Gene Editing: Minding the Past and the Future
Authors: Inmaculada de Melo-Martin
Journal: The American Journal of Bioethics (2020)

In his “Revising, Correcting, and Transferring Genes,” Bryan Cwik calls for a more nuanced evaluation of germline gene editing interventions (Cwik 2020). Cwik contends that not all germline interve...
THU0250 Autoimmune disorders in icelandic multicase sle families
Authors: G Gröndal, K Steinsson
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> <h3>Objectives</h3> To evaluate the frequency of autoimmune disorders in Icelandic multicase SLE families. <h3>Methods</h3> The study group consisted of 38 SLE patients, 127 first-degree relatives, 37 s-degree relatives and 33 nonconsangineous relatives from multicase SLE families. Pedigree members were evaluated through interviews and physical examination, medical records were reviewed. A standardised protocol for SLE and other autoimmune disorders was used. Serum samples were obtained and autoantibodies measured. <h3>Results</h3> Among the SLE patients, 16/38 (42%) had other autoimmune disorder (s) (11 Sjogrens syndrome/sicca symptoms, 3 interstitial cystitis, 3 psoriasis, 3 pernicious anaemia, 3 thyroid disease, 2 myositis). Twenty six/164 (16%) first- and second-degree relatives had various autoimmune disorder (s) (14 Sjogrens syndrome/sicca symptoms, 8 thyroid disease, 6 RA, 3 psoriasis, 3 alopecia, 3 iritis, 1 pernicious anaemia, 1 PBC, 1 MS, 1 DM, 1 AS, 1 reactive athritis, 1 discoid LE). Additionally, 21/164 (13%) relatives had autoantibodies. Therefore either autoimmune disorder (s) or autoantibodies were present in 29% of the relatives. Two of 33 (6%) nonconsangineous relatives had autoimmune disorders and 6/33 (18%) had autoantibodies. <h3>Conclusion</h3> Autoimmune disorders in general are present in increased frequency in these Icelandic multicase SLE families.
Allergome-wide peptide microarrays enable epitope deconvolution in allergen-specific immunotherapy
Authors: Maria Mikus, Arash Zandian, Ronald Sjöberg, Carl Hamsten, Björn Forsström, Morgan Andersson, Lennart Greiff, Mathias Uhlén, Mattias Levin, Peter Nilsson, Marianne van Hage, Mats Ohlin
Journal: Journal of Allergy and Clinical Immunology (2020)

The interaction of allergens and allergen-specific IgE initiates the allergic cascade after crosslinking of receptors on effector cells. Antibodies of other isotypes may modulate such a reaction. Receptor crosslinking requires binding of antibodies to multiple epitopes on the allergen. Limited information is available on the complexity of the epitope structure of most allergens.We sought to allow description of the complexity of IgE, IgG4, and IgG epitope recognition at a global, allergome-wide level during allergen-specific immunotherapy (AIT).We generated an allergome-wide microarray comprising 731 allergens in the form of more than 172,000 overlapping 16-mer peptides. Allergen recognition by IgE, IgG4, and IgG was examined in serum samples collected from subjects undergoing AIT against pollen allergy.Extensive induction of linear peptide-specific Phl p 1- and Bet v 1-specific humoral immunity was demonstrated in subjects undergoing a 3-year-long AIT against grass and birch pollen allergy, respectively. Epitope profiles differed between subjects but were largely established already after 1 year of AIT, suggesting that dominant allergen-specific antibody clones remained as important contributors to humoral immunity following their initial establishment during the early phase of AIT. Complex, subject-specific patterns of allergen isoform and group cross-reactivities in the repertoires were observed, patterns that may indicate different levels of protection against different allergen sources.The study highlights the complexity and subject-specific nature of allergen epitopes recognized following AIT. We envisage that epitope deconvolution will be an important aspect of future efforts to describe and analyze the outcomes of AIT in a personalized manner.
Abstract 14226: Causes of Death in Adults With Congenital Heart Disease Differ by Lesion Severity
Authors: Sarah A Goldstein, Alfred D’Ottavio, Tracy Spears, Karen Chiswell, Manuela Wiedemeier, Toi D Spates, Richard A Krasuski, Alex R Kemper, Robert E Meyer, Timothy M Hoffman, Michael J Walsh, Charlie J Sang, Joseph A Paolillo, Jennifer S Li
Journal: Circulation (2018)

Background: Improved pediatric congenital heart disease (CHD) outcomes have led to rapid growth of the adult CHD population. There are few contemporary studies examining causes of death (COD) in ad...
Abstract 16160: Decrease in Endothelial Mitochondrial Oxidants Improves Post-Myocardial Infarction Cardiac Function Through Activation of Angiogenesis Induced by Increase in Fatty Acid Oxidation
Authors: Rayane Brinck Teixeira, Melissa Pfeiffer, Peng Zhang, Frank W Sellke, Ruhul Abid
Journal: Circulation (2019)

Introduction: Myocardial Infarction (MI) results in increased mitochondrial reactive oxygen species (mito-ROS), leading to endothelial dysfunction and maladaptive remodeling of left ventricle (LV)....
Abstract 10312: Comparison of Clinical Significance of Novel Reactive Oxygen Species Biomarker Among New Categories of Non-ischemic Heart Failure
Authors: Taiki Nishihara, Eiichiro Yamamoto, Daisuke Sueta, Koichiro Fujisue, Hiroki Usuku, Fumi Oike, Masafumi Takae, Takashi Komorita, Seiji Takashio, Kenji Sakamoto, Koichi Kaikita, Kenichi Tsujita
Journal: Circulation (2019)

Introduction: This study investigated the clinical significance of derivative of reactive oxygen metabolites (DROM), a new marker of reactive oxygen species (ROS) in non-ischemic heart failure (NIH...
Breast Cancer Screening and Health Care Costs
Authors: Samantha L. Heller, Linda Moy
Journal: JAMA Internal Medicine (2020)

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Integration of GWAS Summary Statistics and Gene Expression Reveals Target Cell Types Underlying Kidney Function Traits
Authors: Yong Li, Stefan Haug, Pascal Schlosser, Alexander Teumer, Adrienne Tin, Cristian Pattaro, Anna Köttgen, Matthias Wuttke
Journal: Journal of the American Society of Nephrology (2020)

Significance Statement Genome-wide association studies (GWAS) are a powerful tool to identify genetic variants associated with CKD. However, knowledge of CKD-relevant target tissues and cell types important in the pathogenesis is incomplete. Integrating large-scale kidney function GWAS with gene expression datasets identified kidney and liver as the primary organs for kidney function traits. In the kidney, proximal tubule was the critical cell type for eGFR and urate, as well as for monogenic electrolyte or metabolic disease genes. Podocytes showed enrichment of genes implicated in glomerular disease. Compendia connecting traits, genes, and cell types allow further prioritization of genes in GWAS loci, enabling mechanistic studies. Background Genetic variants identified in genome-wide association studies (GWAS) are often not specific enough to reveal complex underlying physiology. By integrating RNA-seq data and GWAS summary statistics, novel computational methods allow unbiased identification of trait-relevant tissues and cell types. Methods The CKDGen consortium provided GWAS summary data for eGFR, urinary albumin-creatinine ratio (UACR), BUN, and serum urate. Genotype-Tissue Expression Project (GTEx) RNA-seq data were used to construct the top 10% specifically expressed genes for each of 53 tissues followed by linkage disequilibrium (LD) score–based enrichment testing for each trait. Similar procedures were performed for five kidney single-cell RNA-seq datasets from humans and mice and for a microdissected tubule RNA-seq dataset from rat. Gene set enrichment analyses were also conducted for genes implicated in Mendelian kidney diseases. Results Across 53 tissues, genes in kidney function–associated GWAS loci were enriched in kidney ( P =9.1E-8 for eGFR; P =1.2E-5 for urate) and liver ( P =6.8·10 -5 for eGFR). In the kidney, proximal tubule was enriched in humans ( P =8.5E-5 for eGFR; P =7.8E-6 for urate) and mice ( P =0.0003 for eGFR; P =0.0002 for urate) and confirmed as the primary cell type in microdissected tubules and organoids. Gene set enrichment analysis supported this and showed enrichment of genes implicated in monogenic glomerular diseases in podocytes. A systematic approach generated a comprehensive list of GWAS genes prioritized by cell type–specific expression. Conclusions Integration of GWAS statistics of kidney function traits and gene expression data identified relevant tissues and cell types, as a basis for further mechanistic studies to understand GWAS loci.
Trajectories of glomerular filtration rate and progression to end stage kidney disease after kidney transplantation
Authors: Marc Raynaud, Olivier Aubert, Peter P. Reese, Yassine Bouatou, Maarten Naesens, Nassim Kamar, Élodie Bailly, Magali Giral, Marc Ladrière, Moglie Le Quintrec, Michel Delahousse, Ivana Juric, Nikolina Basic-Jukic, Gaurav Gupta, Enver Akalin, Daniel Yoo, Chen-Shan Chin, Cécile Proust-Lima, Georg Böhmig, Rainer Oberbauer, Mark D. Stegall, Andrew J. Bentall, Stanley C. Jordan, Edmund Huang, Denis Glotz, Christophe Legendre, Robert A. Montgomery, Dorry L. Segev, Jean-Philippe Empana, Morgan E. Grams, Josef Coresh, Xavier Jouven, Carmen Lefaucheur, Alexandre Loupy
Journal: Kidney International (2020)
Challenges and Opportunities: Using Omics to Generate Testable Insights Into Pathogenic Mechanisms in Preclinical Seropositive Rheumatoid Arthritis
Authors: V. Michael Holers
Journal: Arthritis & Rheumatology (2020)

Our knowledge of the phenotypic and immunologic features present during the preclinical period of seropositive rheumatoid arthritis (RA) has rapidly evolved since the beginning of the 21st Century.
Volume Pledge is Not Associated with Better Short-Term Outcomes After Lung Cancer Resection
Authors: Farhood Farjah, Maria V. Grau-Sepulveda, Henning Gaissert, Mark Block, Eric Grogan, Lisa M. Brown, Andrzej S. Kosinski, Benjamin D. Kozower
Journal: Journal of Clinical Oncology (2020)

We examined the relationship between short-term outcomes and hospitals and surgeons who met minimum volume thresholds for lung cancer resection based on definitions provided by the Volume Pledge. A secondary aim was to evaluate the volume-outcome relationship to determine alternative thresholds in the event the Volume Pledge was not associated with outcomes.We conducted a retrospective study (2015-2017) using the Society of Thoracic Surgeons General Thoracic Surgery Database. We used generalized estimating equations that accounted for confounding and clustering to compare outcomes across hospitals and surgeons who did and did not meet the Volume Pledge criteria: ≥ 40 patients per year for hospitals and ≥ 20 patients per year for surgeons. Our secondary aim was to model volume by using restricted cubic splines to determine the association between volume and short-term outcomes.Among 32,183 patients, 465 surgeons, and 209 hospitals, 16,630 patients (52%) received care from both a hospital and surgeon meeting the Volume Pledge criteria. After adjustment, there was no relationship with operative mortality, complications, major morbidity, a major morbidity-mortality composite end point, or failure to rescue. The Volume Pledge group had a 0.5 day (95% CI, 0.2 to 0.7 day) shorter length of stay. Our secondary aim revealed a nonlinear relationship between hospital volume and complications in which intermediate-volume hospitals had the highest risk of complications. Surgeon volume was associated with major morbidity, a major morbidity-mortality composite end point, and length of stay in an inverse linear fashion. Only 8% of surgeons had volumes associated with better outcomes.The Volume Pledge was not associated with better outcomes except for a marginally shorter length of stay. A re-examination of volume-outcome relationships for hospitals and surgeons yielded mixed results that did not reveal a practical alternative for volume-based quality improvement efforts.
FRI0604-HPR IS STRESS A TRIGGER FOR THE DEVELOPMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS?
Authors: Y. Soria Curi, A. L. Barbaglia, L. Gonzalez Lucero, M. C. Bertolaccini, H. R. Sueldo, S. M. Mazza, M. L. Leguizamón, G. V. Espasa, M. Pera, V. I. Bellomio
Journal: Annals of the Rheumatic Diseases (2020)

Background: Systemic Lupus Erythematosus (SLE) implies multifactorial psychological stress. Although stress has been spreaded as a “trigger” for the onset or flare of connective tissue diseases, there is controversial evidence of the association between stress and the diagnosis of SLE. Objectives: To assess the frequency of stressors and vital events in patients with SLE and their relationship with the diagnosis. Methods: A descriptive cross-sectional study was conducted. It were included patients over 18 years old with SLE diagnosis (ACR/SLICC criteria), attended in the Rheumatology Unit between May and August 2019; and 101 patients without any autoimmune disease. Demographic and disease-related variables were studied. The Holmes and Rahe Vital Events scale (43 questions) was used to evaluate vital events and measure the magnitude of stress that a person has experienced for a while and predict the onset of SLE. The sum of the scores indicates the magnitude of vital stress experienced by a person and the predisposition to acquire a disease. It was classified as: &lt;150: small risk of illness due to stress; 150-299: moderate risk; and ≥ 300: high risk. Results: 94 patients with SLE were included, of which 94% were women. The mean age was 36.3 ± 10.3 years. 41.9% of the cases had a family history of rheumatic disease and 31.2% of them were unemployed. During the year before the diagnosis of SLE, 48.4% of the patients suffered a stressful situation, the most frequent cause was the death of a close family member (44.1%). Patients with SLE presented significantly higher stress scores than the healthy group (140 ± 27 vs. 45.1 ± 43, p=0.0001); 54.8% of patients with SLE had a score &lt;150; 23.65% between 150-299; and 10.75% ≥ 300. The number of patients with SLE was higher in the moderate and high risk categories (&gt;150) than the healthy group (34% vs. 2%, p=0.0001). When studying the Holmes and Rahe scale factors individually, patients with SLE had a higher frequency of situations related to: death of the couple (p=0.029), death of a close relative (p=0.0001), injury or personal illness (p=0.006), change in living conditions (p=0.0001) and poor relationship with the couple (p=0.017). Conclusion: Patients with SLE presented high frequency of stressful situations before diagnosis (48.4%), and higher scores compared to the healthy group. The death of a close family member was the most frequent stressful event. Disclosure of Interests: None declared
Abstract 9696: Application and Clinical Benefit of Primary Percutaneous Coronary Intervention in Elderly Patients With Acute Myocardial Infarction - an Analysis From a Japanese Nationwide Database -
Authors: Shiro Uemura, Hiroshi Okamoto, Michikazu Nakai, Kunihiro Nishimura, Yoshihiro Miyamoto, Masato Nakamura, Hiroyuki Tsutsui, Hisao Ogawa, Issei Komuro, Yuji Ikari
Journal: Circulation (2019)

Introduction: Primary percutaneous coronary intervention (pPCI) is strongly recommended by guidelines for patients presenting with acute myocardial infarction (AMI), albeit its applications and cli...
Dual-Color Single-Cell Imaging of the Suprachiasmatic Nucleus Reveals a Circadian Role in Network Synchrony
Authors: Yongli Shan, John H. Abel, Yan Li, Mariko Izumo, Kimberly H. Cox, Byeongha Jeong, Seung-Hee Yoo, David P. Olson, Francis J. Doyle, Joseph S. Takahashi
Journal: Neuron (2020)
Examining the Role of NF‐E2–Related Factor 2 in Lupus: Comment on the Article by Han et al
Authors: Wang-Dong Xu, An-Fang Huang
Journal: Arthritis & Rheumatology (2020)

Systemic lupus erythematosis (SLE) is an inflammatory autoimmune disease with multiple organs, systems damage. To date, the clear pathogenesis of SLE has not been fully clarified. However, genetics, environmental factors and dysregulated immunity were related to onset of this complex disease.
NEO-ZOTAC : Toxicity data of a phase Ill randomized trial with NEOadjuvant chemotherapy (TAC) with or without ZOledronic acid (ZA) for patients with HER2-negative large resectable or locally advanced breast cancer (BC)
Authors: S.V. de Yen, G.J. Liefers, H. Putter, L.J. van Warmerdam, L.W. Kessels, W. Dercksen, M.J. Pepels, E. Maartense, H.W.M. van Laarhoven, B. Vriens, V.T.H.B.M. Smit, M.N.J.M. Wasser, K.E.M. Meershoek-Klein, E. van Leeuwen-Stok, C.J.H. van de Velde, J.W.R. Nortier, J.R. Kroep
Journal: Cancer Research (2012)