tbuckley/cabot-search huggingface dataset:
Correlative Analyses of Cereblon (CRBN), cMYC, IRF4, BLIMP1, and XBP1 with Clinical Outcomes in Stratus (MM-010), a Phase 3b Study of Pomalidomide (POM) + Low-Dose Dexamethasone (LoDEX) in Patients (pts) with Relapsed/Refractory Multiple Myeloma (RRMM)
Authors: Xiaozhong Qian, Meletios A. Dimopoulos, Michael Amatangelo, Chad Bjorklund, Katja C. Weisel, Enrique M. Ocio, Xin Yu, Teresa Peluso, Lars Sternas, Mohamed Zaki, Philippe Moreau, Anjan Thakurta
Journal: Blood (2017)
GeneXpert for the diagnosis of COVID-19 in LMICs
Authors: Niaina Rakotosamimanana, Frédérique Randrianirina, Rindra Randremanana, Mamy S Raherison, Voahangy Rasolofo, Gaetan D Solofomalala, André Spiegel, Jean-Michel Heraud
Journal: The Lancet Global Health (2020)
Omega-3 fatty acids improve flow-induced vasodilation by enhancing TRPV4 in arteries from diet-induced obese mice
Authors: Yifei Zhu, Lei Wen, Sheng Wang, Ka Zhang, Yue Cui, Chi Zhang, Lei Feng, Fan Yu, Yongquan Chen, Ruxing Wang, Xin Ma
Journal: Cardiovascular Research (2020)

Previous studies have shown the intake of omega-3 polyunsaturated fatty acids is associated with low rates of obesity and ischaemic pathologies. Omega-3 also have anti-inflammatory and plaque-stabilization effects and regulate vasodilation and constriction. However, there are few studies of the role of omega-3 in flow-induced vasodilation involving Ca2+-permeable ion channel TRPV4 in high-fat diet-induced obese (DIO) mouse. Here, we determined whether omega-3 protect against vascular dysfunction induced by a high-fat diet by enhancing TRPV4 activity and subsequently improving flow-mediated vasodilation.
Christopher Michael Taylor
Authors: Rachel Regan
Journal: BMJ (2020)

Christopher Michael Taylor (“Chris”) was born in Bowden, Lancashire on 27 July 1952. He was the first-born twin, and his sister followed minutes later—much to the surprise and shock of his mother and father, who had no idea they were expecting twins. From a very early age, Chris showed an enquiring and inquisitive mind. He came from a humble background and his education saw him pass the 11-plus, giving him the chance to attend Hutton Grammar School, near Preston. From there, he was accepted to read medicine (preclinical sciences) at Christ’s College, Cambridge, from where he was awarded his MA in 1977, having completed his medical training at King’s College London.

His postgraduate training took him to Hastings, where he worked at St Helen’s Hospital as a house officer. Here he met his future wife, Sue, who at the time worked as a nurse in the same hospital. They married in Coventry in 1978.

Chris was fascinated by neuropsychiatry and this interest led him to begin psychiatric training; he completed his MRCPsych in Coventry in 1981. He …
Insertion Site and Infection Risk among Peripheral Arterial Catheters
Authors: Niccolò Buetti, Olivier Mimoz, Carole Schwebel, Stéphane Ruckly, Mathieu Castry, Claire Dupuis, Bertrand Souweine, Jean-Christophe Lucet, Jean-François Timsit
Journal: American Journal of Respiratory and Critical Care Medicine (2020)

"Insertion Site and Infection Risk among Peripheral Arterial Catheters." American Journal of Respiratory and Critical Care Medicine, 203(5), pp. 630–633
Consequences of Perioperative Serotonin Reuptake Inhibitor Treatment During Hepatic Surgery
Authors: Patrick Starlinger, David Pereyra, Hubert Hackl, Gregor Ortmayr, Eva Braunwarth, Jonas Santol, Sina Najarnia, Michael R. Driedger, Lindsey Gregory, Roberto Alva‐Ruiz, Amy Glasgow, Alice Assinger, David M. Nagorney, Elizabeth B. Habermann, Stefan Staetttner, Sean P. Cleary, Rory L. Smoot, Thomas Gruenberger
Journal: Hepatology (2020)

Platelet-stored serotonin critically affects liver regeneration in mice and humans. Selective serotonin reuptake inhibitors (SSRIs) and serotonin noradrenalin reuptake inhibitors (SNRIs) reduce intraplatelet serotonin. As SSRIs/SNRIs are now one of the most commonly prescribed drugs in the United States and Europe and given serotonin's impact on liver regeneration, we evaluated whether perioperative use of SSRIs/SNRIs affects outcome after hepatic resection.Consecutive patients undergoing hepatic resection (n = 754) were retrospectively included from prospectively maintained databases from two European institutions. Further, an independent cohort of 495 patients from the United States was assessed to validate our exploratory findings. Perioperative intake of SSRIs/SNRIs was recorded, and patients were followed up for postoperative liver dysfunction (LD), morbidity, and mortality. Perioperative intraplatelet serotonin levels were significantly decreased in patients receiving SSRI/SNRI treatment. Patients treated with SSRIs/SNRIs showed a higher incidence of morbidity, severe morbidity, LD, and LD requiring intervention. Associations were confirmed in the independent validation cohort. Combined cohorts documented a significant increase in deleterious postoperative outcome (morbidity odds ratio [OR], 1.56; 95% confidence interval [CI], 1.07-2.31; severe morbidity OR, 1.86; 95% CI, 1.22-2.79; LD OR, 1.96; 95% CI, 1.23-3.06; LD requiring intervention OR, 2.22; 95% CI, 1.03-4.36). Further, multivariable analysis confirmed the independent association of SSRIs/SNRIs with postoperative LD, which was closely associated with postoperative 90-day mortality and 1-year overall survival.We observed a significant association of perioperative SSRI/SNRI intake with adverse postoperative outcome after hepatic resection. This indicates that SSRIs/SNRIs should be avoided perioperatively in patients undergoing hepatic resections.
Relapse After Early-Stage, Favorable Hodgkin Lymphoma: Disease Characteristics and Outcomes With Conventional or High-Dose Chemotherapy
Authors: Paul J. Bröckelmann, Horst Müller, Teresa Guhl, Karolin Behringer, Michael Fuchs, Alden A. Moccia, Andreas Rank, Martin Soekler, Tom Vieler, Thomas Pabst, Christian Baues, Bastian von Tresckow, Peter Borchmann, Andreas Engert
Journal: Journal of Clinical Oncology (2020)

PURPOSE We evaluated disease and treatment characteristics of patients with relapse after risk-adapted first-line treatment of early-stage, favorable, classic Hodgkin lymphoma (ES-HL). We compared second-line therapy with high-dose chemotherapy and autologous stem cell transplantation (ASCT) or conventional chemotherapy (CTx). METHODS We analyzed patients with relapse after ES-HL treated within the German Hodgkin Study Group HD10+HD13 trials. We compared, by Cox proportional hazards regression, progression-free survival (PFS) after relapse (second PFS) treated with either ASCT or CTx and performed sensitivity analyses with overall survival (OS) from relapse and Kaplan-Meier statistics. RESULTS A total of 174 patients’ disease relapsed after treatment in the HD10 (n = 53) and HD13 (n = 121) trials. Relapse mostly occurred &gt; 12 months after first diagnosis, predominantly with stage I-II disease. Of 172 patients with known second-line therapy, 85 received CTx (49%); 70, ASCT (41%); 11, radiotherapy only (6%); and 4, palliative single agent therapies (2%). CTx was predominantly bleomycin, etoposide, doxorubicin cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPP [68%]), followed by the combination regimen of doxorubicin, bleomycin, vinblastine, and dacarbazine (19%), or other regimens (13%). Patients aged &gt; 60 years at relapse had shorter second PFS (hazard ratio [HR], 3.0; P = .0029) and were mostly treated with CTx (n = 33 of 49; 67%) and rarely with ASCT (n = 8; 16%). After adjustment for age and a disadvantage of ASCT after the more historic HD10 trial, we did not observe a significant difference in the efficacy of CTx versus ASCT for second PFS (HR, 0.7; 95% CI, 0.3 to 1.6; P = .39). In patients in the HD13 trial who were aged ≤ 60 years, the 2-year, second PFS rate was 94.0% with CTx (95% CI, 85.7% to 100%) versus 83.3% with ASCT (95% CI, 71.8% to 94.8%). Additional sensitivity analyses including OS confirmed these observations. CONCLUSION After contemporary treatment of ES-HL, relapse mostly occurred &gt; 12 months after first diagnosis. Polychemotherapy regimens such as BEACOPP are frequently administered and may constitute a reasonable treatment option for selected patients with relapse after ES-HL.
Metastatic Disease as a Distinct Discipline in Radiation Oncology
Authors: C. Jillian Tsai, Daniel R. Gomez, T. Jonathan Yang
Journal: JAMA Oncology (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
The Overlapping Neurobiology of Induced and Pathological Anxiety: A Meta-Analysis of Functional Neural Activation
Authors: Alice V. Chavanne, Oliver J. Robinson
Journal: American Journal of Psychiatry (2020)

Although anxiety can be an adaptive response to unpredictable threats, pathological anxiety disorders occur when symptoms adversely affect daily life. Whether or not adaptive and pathological anxiety share mechanisms remains unknown, but if they do, induced (adaptive) anxiety could be used as an intermediate translational model of pathological anxiety to improve drug development pipelines. The authors therefore compared meta-analyses of functional neuroimaging studies of induced and pathological anxiety.A systematic search of the PubMed database was conducted in June 2019 for whole-brain functional MRI articles. Eligible articles contrasted either anxious patients to control subjects or an unpredictable-threat condition to a safe condition in healthy participants. Five anxiety disorders were included: posttraumatic stress disorder, social anxiety disorder, generalized anxiety disorder, panic disorder, and specific phobia. A total of 3,433 records were identified, 181 articles met selection criteria, and the largest subset of task type was emotional (N=138). Seed-based d-mapping software was used for all analyses.Induced anxiety (N=693 participants) and pathological anxiety (N=2,554 patients and 2,348 control subjects) both showed increased activation in the left and right insula (coordinates, 44, 14, -14 and -38, 20, -8; k=2,102 and k=1,305, respectively) and cingulate cortex/medial prefrontal cortex (-12, -8, 68; k=2,217). When the analyses were split by disorder, specific phobia appeared the most, and generalized anxiety disorder the least, similar to induced anxiety.This meta-analysis indicates a consistent pattern of activation across induced and pathological anxiety, supporting the proposition that some neurobiological mechanisms overlap and that the former may be used as a model for the latter. Induced anxiety might nevertheless be a better model for some anxiety disorders than others.
Long‐Term Observation of Cyclosporine as Second‐Line Therapy in Adults for Severe Acute Autoimmune Hepatitis
Authors: Fumie Noguchi, Po‐sung Chu, Nobuhito Taniki, Aya Yoshida, Rei Morikawa, Akihiro Yamaguchi, Akihiko Ikura, Karin Yamataka, Hitomi Hoshi, Shingo Usui, Hirotoshi Ebinuma, Hidetsugu Saito, Takanori Kanai, Nobuhiro Nakamoto
Journal: Hepatology (2020)

Noguchi, Fumie; Chu, Po‐sung; Taniki, Nobuhito; Yoshida, Aya; Morikawa, Rei; Yamaguchi, Akihiro; Ikura, Akihiko; Yamataka, Karin; Hoshi, Hitomi; Usui, Shingo; Ebinuma, Hirotoshi; Saito, Hidetsugu; Kanai, Takanori; Nakamoto, Nobuhiro Author Information
Unique immunological profile in patients with COVID-19
Authors: Stefania Varchetta, Dalila Mele, Barbara Oliviero, Stefania Mantovani, Serena Ludovisi, Antonella Cerino, Raffaele Bruno, Alberto Castelli, Mario Mosconi, Marco Vecchia, Silvia Roda, Michele Sachs, Catherine Klersy, Mario U. Mondelli
Journal: Cellular and Molecular Immunology (2020)

The relationship between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and host immunity is poorly understood. We performed an extensive analysis of immune responses in 32 patients with severe COVID-19, some of whom succumbed. A control population of healthy subjects was included. Patients with COVID-19 had an altered distribution of peripheral blood lymphocytes, with an increased proportion of mature natural killer (NK) cells and low T-cell numbers. NK cells and CD8+ T cells overexpressed T-cell immunoglobulin and mucin domain-3 (TIM-3) and CD69. NK cell exhaustion was attested by increased frequencies of programmed cell death protein 1 (PD-1) positive cells and reduced frequencies of natural killer group 2 member D (NKG2D)-, DNAX accessory molecule-1 (DNAM-1)- and sialic acid-binding Ig-like lectin 7 (Siglec-7)-expressing NK cells, associated with a reduced ability to secrete interferon (IFN)γ. Patients with poor outcome showed a contraction of immature CD56bright and an expansion of mature CD57+ FcεRIγneg adaptive NK cells compared to survivors. Increased serum levels of IL-6 were also more frequently identified in deceased patients compared to survivors. Of note, monocytes secreted abundant quantities of IL-6, IL-8, and IL-1β which persisted at lower levels several weeks after recovery with concomitant normalization of CD69, PD-1 and TIM-3 expression and restoration of CD8+ T cell numbers. A hyperactivated/exhausted immune response dominate in severe SARS-CoV-2 infection, probably driven by an uncontrolled secretion of inflammatory cytokines by monocytes. These findings unveil a unique immunological profile in COVID-19 patients that will help to design effective stage-specific treatments for this potentially deadly disease.
Predominant DNMT and TET mediate effects of allergen on the human bronchial epithelium in a controlled air pollution exposure study
Authors: Hang Li, Min Hyung Ryu, Christopher F. Rider, Wayne Tse, Rachel L. Clifford, Maria J. Aristizabal, Weiping Wen, Chris Carlsten
Journal: Journal of Allergy and Clinical Immunology (2020)
Associations between statin use and suicidality, depression, anxiety, and seizures: a Swedish total-population cohort study
Authors: Yasmina Molero, Andrea Cipriani, Henrik Larsson, Paul Lichtenstein, Brian M D'Onofrio, Seena Fazel
Journal: The Lancet Psychiatry (2020)

Statins have shown both protective and adverse associations with neuropsychiatric outcomes. We aimed to examine the possible associations between statins and suicidality, depression, anxiety, and seizures.Using Swedish national registers, we linked data on dispensed statin prescriptions with data on unplanned (emergency) hospital visits or specialised outpatient care for four neuropsychiatric outcomes: suicidal behaviour (including deaths from suicide), depressive disorders, anxiety disorders, and seizures. We included all individuals in the registries who were dispensed statins and who were aged 15 years or older between Jan 1, 2006, and Dec 31, 2013. We applied a within-individual design using stratified Cox proportional hazards regression to compare the incidence of the defined outcomes during periods on statins and periods off statins within each individual, thus adjusting for time-invariant confounders. Non-specific effects of treatment were tested by investigating these outcomes in relation to thiazide diuretic use and antihistamine use in the same cohort.The statin-users cohort comprised 1 149 384 individuals, of whom 1 015 949 (88·4%) were aged 50 years or older, 625 616 (54·4%) were male, and 523 768 (45·6%) were female. The study period consisted of 2 053 310 non-treatment periods and 2 997 545 treatment periods, and 957 216 (83·3%) individuals had a medication status change (from on statins to off statins, or vice versa). Suicide outcomes were found in 6372 (0·6%) individuals, depressive disorders in 23 745 (2·1%), anxiety disorders in 30 100 (2·6%), and seizures in 28 844 (2·5%). There were no clear associations between periods of statin treatment and suicidal behaviour or deaths from suicide (hazard ratio 0·99 [95% CI 0·90-1·08]), anxiety disorders (0·99 [0·95-1·02]), or seizures (1·00 [0·97-1·04]). Statins were associated with reduced hazards of depressive disorders (0·91 [0·87-0·94]), which remained after adjustment for concurrent antidepressant use (0·91 [0·88-0·94]). Hazard ratios for depressive disorders were 0·61 (0·38-1·00; n=14 718) with thiazide diuretic use and 0·84 (0·67-1·06; n=23 715) with antihistamine use.Statin use is not associated with suicidality, anxiety disorders, or seizures. Whether the observed association between statin use and reduced diagnoses of clinical depression is confounded by non-specific benefits related to being prescribed medication needs further research.Wellcome Trust, Swedish Research Council, National Institute for Health Research (NIHR) Research Professorship, NIHR Oxford Health Biomedical Research Centre, American Foundation for Suicide Prevention, Karolinska Institutet.
Amisulpride, aripiprazole, and olanzapine in patients with schizophrenia-spectrum disorders (BeSt InTro): a pragmatic, rater-blind, semi-randomised trial
Authors: Erik Johnsen, Rune A Kroken, Else-Marie Løberg, Maria Rettenbacher, Inge Joa, Tor Ketil Larsen, Solveig Klæbo Reitan, Berit Walla, Renata Alisauskiene, Liss Gøril Anda, Christoffer Bartz-Johannessen, Jan Øystein Berle, Jill Bjarke, Farivar Fathian, Kenneth Hugdahl, Eirik Kjelby, Igne Sinkeviciute, Silje Skrede, Lena Stabell, Vidar M Steen, W Wolfgang Fleischhacker
Journal: The Lancet Psychiatry (2020)
Sixty seconds on . . . hawks <i>v</i> doves
Authors: Abi Rimmer
Journal: BMJ (2020)

No, not yet. In fact, this is a political term that is being used to describe two different factions of government—those in favour of lockdown to tackle the covid-19 pandemic and those against.

It’s a phrase obscured by the wings of time but seems to have been first used in the 19th century US as a description for those in …
Association of Agricultural, Occupational, and Military Inhalants With Autoantibodies and Disease Features in US Veterans With Rheumatoid Arthritis
Authors: Ariadne V. Ebel, Gabrielle Lutt, Jill A. Poole, Geoffrey M. Thiele, Joshua F. Baker, Grant W. Cannon, Angelo Gaffo, Gail S. Kerr, Andreas Reimold, Pascale Schwab, Namrata Singh, J. Steuart Richards, Dana P. Ascherman, Ted R. Mikuls, Bryant R. England
Journal: Arthritis & Rheumatology (2020)

Objective To determine the association of inhalant exposures with rheumatoid arthritis (RA)–related autoantibodies and severity in US veterans. Methods Participants in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were mailed surveys assessing occupational, agricultural, and military inhalant exposures. Demographic characteristics, disease activity, functional status, and extraarticular features were obtained from the VARA registry, while HLA–DRB1 shared epitope (SE) status, anti–cyclic citrullinated peptide (anti‐CCP) antibodies, and rheumatoid factor (RF) were measured using banked DNA/serum from enrollment. Associations between inhalant exposures and RA‐related factors (autoantibodies, severity, and extraarticular features) were assessed using multivariable linear and logistic regression models adjusted for age, sex, race, and tobacco use and stratified by SE status. Adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. Results Questionnaires were returned by 797 of 1,566 participants (50.9%). Survey respondents were older, more often White or male, and less frequently smokers, and had lower disease activity compared to nonrespondents. Anti‐CCP positivity was more common among veterans exposed to burn pits (OR 1.66 [95% CI 1.02, 2.69]) and military waste disposal (OR 1.74 [95% CI 1.04, 2.93]) independent of other factors. Among participants who were positive for SE alleles, burn pit exposure (OR 5.69 [95% CI 2.73, 11.87]) and military waste disposal exposure (OR 5.05 [95% CI 2.42, 10.54]) were numerically more strongly associated with anti‐CCP positivity. Several inhalant exposures were associated with the presence of chronic lung disease, but not with the presence of RF or the level of disease activity. Conclusion Military burn pit exposure and military waste disposal exposure were independently associated with the presence of anti‐CCP antibodies in RA patients. These findings are consistent with emerging evidence that various inhalant exposures influence autoantibody expression and RA risk.
PIMD: An Integrative Approach for Drug Repositioning using Multiple Characterization Fusion
Authors: Song He, Yuqi Wen, Xiaoxi Yang, Zhen Liu, Xinyu Song, Xin Huang, Xiaochen Bo
Journal: Genomics Proteomics & Bioinformatics (2020)

Abstract The accumulation of various types of drug informatics data and computational approaches for drug repositioning can accelerate pharmaceutical research and development. However, the integration of multi-dimensional drug data for precision repositioning remains a pressing challenge. Here, we propose a systematic framework named PIMD to predict drug therapeutic properties by integrating multi-dimensional data for drug repositioning. In PIMD, drug similarity networks (DSNs) based on chemical, pharmacological, and clinical data are fused into an integrated DSN (iDSN) composed of many clusters. Rather than simple fusion, PIMD offers a systematic way to annotate clusters. Unexpected drugs within clusters and drug pairs with a high iDSN similarity score are therefore identified to predict novel therapeutic uses. PIMD provides new insights into the universality, individuality, and complementarity of different drug properties by evaluating the contribution of each property data. To test the performance of PIMD, we use chemical, pharmacological, and clinical properties to generate an iDSN. Analyses of the contributions of each drug property indicate that this iDSN was driven by all data types and performs better than other DSNs. Within the top 20 recommended drug pairs, 7 drugs have been reported to be repurposed. The source code for PIMD is available at https://github.com/Sepstar/PIMD/.
Construction of thiol-capped ultrasmall Au–Bi bimetallic nanoparticles for X-ray CT imaging and enhanced antitumor therapy efficiency
Authors: Fei He, Hongjiao Ji, Lili Feng, Zhao Wang, Qianqian Sun, Chongna Zhong, Dan Yang, Shili Gai, Piaoping Yang, Jun Lin
Journal: Biomaterials (2020)