tbuckley/cabot-search huggingface dataset:
Phase II Trial of Single Agent Bortezomib (VELCADE®) in Patients with Previously Untreated Multiple Myeloma (MM).
Authors: Paul G. Richardson, Asher Chanan-Khan, Robert L. Schlossman, Nikhil C. Munshi, Patrick Wen, Hannah Briemberg, David Kuter, Anne-Louise Oaklander, Sagar Lonial, Hani Hassoun, Deborah Doss, Kathleen Colson, Mary McKenney, Karen Hande, Alexandra Koryzna, Barbara Stoklas, Laura Lunde, Svetlana Gorelik, Cliona McAlister, Andrea Freeman, Diane Warren, Denise Collins, Dixie Esseltine, Anthony Amato, Kenneth C. Anderson
Journal: Blood (2004)
Phase I study of nivolumab or nivolumab/cisplatin/gemcitabine to treat unresectable/recurrent biliary tract cancer
Authors: Chigusa Morizane, Masafumi Ikeda, Makoto Ueno, Satoshi Kobayashi, Izumi Ohno, Shunsuke Kondo, Naohiro Okano, Keisuke Kimura, Suguru Asada, Yoshinobu Namba, Takuji Okusaka, Junji Furuse
Journal: Annals of Oncology (2019)
Identification of Novel Tumor-Associated Antigens for Chronic Lymphocytic Leukemia (CLL) Based On HLA Ligandome Analysis – New Targets for Peptide Based Immunotherapy
Authors: Daniel Johannes Kowalewski, Heiko Schuster, Claudia Berlin, Lothar Kanz, Helmut R Salih, Hans-Georg Rammensee, Stefan Stevanovic, Juliane Sarah Stickel
Journal: Blood (2012)
Induction of sequential G1 arrest and synchronous S phase entry by reversible CDK4/CDK6 inhibition sensitizes myeloma cells for cytotoxic killing through loss of IRF-4.
Authors: Xiangao Huang, Maurizio Di Liberto, Scott Ely, David S Jayabalan, Isan Chen, Keith D. Wilner, Malcolm Moore, Ruben Niesvizky, Selina Chen-Kiang
Journal: Blood (2009)
Digital Restriction Enzyme Analysis of Methylation (DREAM) by Next Generation Sequencing Uncovers Epigenetic Disturbances In Acute Myelogenous Leukemia.
Authors: Frank Neumann, Jean-Pierre Issa, Yue Lu, Marcos R Estecio, Rong He, Louis Ramagli, Shoudan Liang, Jaroslav Jelinek
Journal: Blood (2010)
Hypomethylating Agents and Casein Kinase 2 Inhibitor Act Synergistic and Reveal Significant Anti-Leukemic Effects in Acute Lymphoblastic Leukemia Cells
Authors: Catrin Roolf, Anna Richter, Christoph Konkolefski, Yascha Khodamoradi, Gudrun Knuebel, Anett Sekora, Jan Stenzel, Bernd Joachim Krause, Brigitte Vollmar, Irmela Jeremias, Jens P. Panse, Hugo Murua Escobar, Christian Junghanss
Journal: Blood (2016)
Evidence-Based Drug Treatment of Acute Depression in Bipolar Disorder
Authors: Bruce M. Cohen
Journal: JAMA Psychiatry (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Lenalidomide Therapy in Nine Patients with POEMS Syndrome.
Authors: Arnaud Jaccard, Julie Abraham, Christian Recher, Remy Dulery, Isabelle Guichard, Julien Haroche, Bouchra Asli, Zahir Amoura, Jean Marie Brissaud, Lucille Musset, Thierry Facon, Veronique Leblond, Philippe Moreau, Jean-Paul Fermand, Dominique Bordessoule
Journal: Blood (2009)
Development of ASAS quality standards to improve the quality of health and care services for patients with axial spondyloarthritis
Authors: Uta Kiltz, Robert B M Landewé, Désirée van der Heijde, Martin Rudwaleit, Michael H Weisman, Nurullah Akkoc, Annelies Boonen, Jan Brandt, Philippe Carron, Maxime Dougados, Laure Gossec, Merryn Jongkees, Pedro M Machado, Helena Marzo-Ortega, Anna Molto, Victoria Navarro-Compán, Karin Niederman, Percival Degrava Sampaio-Barros, Gleb Slobodin, Filip E Van den Bosch, Astrid van Tubergen, Salima van Weely, Dieter Wiek, Juergen Braun
Journal: Annals of the Rheumatic Diseases (2019)

Objectives The Assessment of SpondyloArthritis International Society (ASAS) aimed to develop a set of quality standards (QS) to help improve the quality of healthcare provided to adult patients affected by axial spondyloarthritis (axSpA) worldwide. Methods An ASAS task force developed a set of QS using a stepwise approach. First, key areas for quality improvement were identified, discussed, rated and agreed on. Thereafter, areas were prioritised and statements for the most important key areas were phrased on consensus. Appropriate quality measures were defined to allow quantification of the QS at the community level. Results The ASAS task force, consisting of 20 rheumatologists, two physiotherapists and two patients, selected and proposed 34 potential key areas for quality improvement which were then commented by 140 ASAS members and patients. Within that process three new key areas came up, which led to a re-evaluation of all 37 key areas by 120 ASAS members and patients. Five key areas were identified as most important to determine quality of care: referral including rapid access, rheumatology assessment, treatment, education/self-management and comorbidities. Finally, nine QS were agreed on and endorsed by the whole ASAS membership. Conclusions ASAS successfully developed the first set of QS to help improving healthcare for adult patients with axSpA. Even though it may currently not be realistic to achieve the QS in all healthcare systems, they provide high-quality of care framework for patients with axSpA that should be aimed for.
Signal Transducer and Activator of Transcription (STAT)-3 Induces Granulocyte/Macrophage Colony-Stimulating Factor (GM-CSF) Receptor-α Expression in Chronic Lymphocytic Leukemia (CLL) Cells,
Authors: Ping Li, Zhiming Liu, David Harris, Alessandra Ferrajoli, Yongtao Wang, Inbal Hazan-Halevy, Srdana Grgurevic, William G. Wierda, Jan A. Burger, Susan O'Brien, Stefan Faderl, Michael J Keating, Zeev Estrov
Journal: Blood (2011)
Immuno-oncology biomarker study in non-small cell lung cancer harboring oncogenic driver alterations: LC-SCRUM-IBIS
Authors: Masahiro Kodani, Kiyotaka Yoh, Shingo Matsumoto, Kei Kunimasa, Koichi Nishi, Taku Nakagawa, Shunichi Sugawara, Tomohiro Kato, Jun Sakakibara-Konishi, Koji Tsuta, Yuichiro Hayashi, Noriko Motoi, Genichiro Ishii, Koichi Goto
Journal: Annals of Oncology (2019)
Gain of 1q21 Does Not Predict for Immediate Progression in MGUS.
Authors: Laura Chiecchio, Gian Paolo Dagrada, Elizabet Dachs Cabanas, Rebecca K.M. Protheroe, David M. Stockley, Zoe J. Konn, Nicholas C.P. Cross, Christine J. Harrison, Fiona M. Ross
Journal: Blood (2009)
Efficacy and Safety of Obinutuzumab (GA101) Monotherapy in Relapsed/Refractory Indolent Non-Hodgkin's Lymphoma: Results From a Phase I/II Study (BO20999)
Authors: Gilles Andre Salles, Franck Morschhauser, Catherine Thieblemont, Philippe Solal-Celigny, Thierry Lamy, Herve Tilly, Pierre Feugier, Steven Le Gouill, Emmanuel Gyan, Reda Bouabdallah, Michael K. Wenger, Elisabeth Wassner-Fritsch, Elina Asikanius, Guillaume Cartron
Journal: Blood (2011)
Anti-HLA-DR Monoclonal Antibody Evokes a Novel Non-Apoptotic Cell Death Pathway In Acute Lymphoblastic Leukemia
Authors: Khimara Naidoo, Waleed Alduaij, Jamie Honeychurch, Eleanor Cheadle, Seema Alexander, Richard Byers, Vaskar Saha, Tim Illidge
Journal: Blood (2010)
Head-To-Head Comparison Of Obinutuzumab (GA101) Plus Chlorambucil (Clb) Versus Rituximab Plus Clb In Patients With Chronic Lymphocytic Leukemia (CLL) and Co-Existing Medical Conditions (Comorbidities): Final Stage 2 Results Of The CLL11 Trial
Authors: Valentin Goede, Kirsten Fischer, Raymonde Busch, Anja Engelke, Barbara Eichhorst, Clemens M Wendtner, Tatiana Chagorova, Javier De la Serna, Marie-Sarah Dilhuydy, Stephen Opat, Carolyn J. Owen, Olga Samoylova, Karl-Anton Kreuzer, Anton W Langerak, Matthias Ritgen, Stephan Stilgenbauer, Hartmut Döhner, Elina Asikanius, Kathryn Humphrey, Michael K Wenger, Michael Hallek
Journal: Blood (2013)
Update of the Hyper-CVAD and Imatinib Mesylate Regimen in Philadelphia (Ph) Positive Acute Lymphocytic Leukemia (ALL).
Authors: Deborah A. Thomas, Stefan Faderl, Jorge Cortes, Susan O’Brien, Francis Giles, Guillermo Garcia, Steven Kornblau, Michael Andreeff, Miloslav Beran, Srdan Verstovsek, Sherry Pierce, Laurie Letvak, August Salvado, Richard Champlin, Hagop Kantarjian
Journal: Blood (2004)
The PIM1 Oncogene Accelerates TCL1 Driven Lymphomagenesis in a Double-Transgenic Murine Model.
Authors: Evelena Ontiveros, David Dae-Young Kim, Jeffrey M Calimlim, Matthew I. Schrage, Quang T Luong, Debra Tosity, Bao Ngan Doan, Brandon Castor, Michael A. Teitell, Jonathan W Said, Sven De Vos
Journal: Blood (2009)
A Role for Plasma Urokinase Plasminogen Activator Receptor (uPAR) in Thrombosis in Paroxysmal Nocturnal Hemoglobinuria (PNH).
Authors: Elaine M. Sloand, Lori Mainwaring, Elaine Wong, Yong Tang, McDonald K. Horne, Neal S. Young
Journal: Blood (2004)
Overall Safety and Treatment Duration in Lenalidomide (LEN)-, Thalidomide (THAL)-, and Bortezomib (BORT)-Treated Patients (Pts) within the European Post-Approval Safety Study (EU PASS) of Relapsed/Refractory Multiple Myeloma (RRMM)
Authors: Barbara Gamberi, Charalampia Kyriakou, John Ashcroft, Miguel T. Hernandez, Jo Caers, Gerard Bos, Maria Asunción Echeveste, Christian Berthou, Renato Zambello, Elisabeth Küenburg, Barbara Rosettani, Brooke Ryder-Smith, Igor W. Blau
Journal: Blood (2012)
Results from a Phase IIa Study of the Anti-CXCL12 Spiegelmer Olaptesed Pegol (NOX-A12) in Combination with Bendamustine/Rituximab in Patients with Chronic Lymphocytic Leukemia
Authors: Michael Steurer, Marco Montillo, Lydia Scarfò, Francesca Romana Mauro, Johannes Andel, Sophie Wildner, Livio Trentin, Ann Janssens, Sonja Burgstaller, Anna Kruschinski, Thomas Dümmler, Kai Riecke, Paolo Ghia, Federico Caligaris-Cappio, Marco Gobbi
Journal: Blood (2014)
Rituximab Combined With Three Cycles Of High Dose Dexamethasone Provides a Long Term Response Rate Similar To That Of Splenectomy In Patients With Immune Thrombocytopenia (ITP) Of Duration Less Than 2 Years
Authors: Christina S Lee, Allison Imahiyerobo, Micha Thompson, Marina Izak Karaev, Waleed Ghanima, James B Bussel
Journal: Blood (2013)
Yearly Long-Acting Zoledronic Acid (Reclast) Is Safe and Effective for Treatment of Bone Loss after Hematopoietic Stem Cell Transplantation
Authors: Zhuoyan Li, Samuel M Rubinstein, Carey Clifton, Leigh Ann Vaughan, Melissa Logue, Michael T. Byrne, Adetola A. Kassim, Brian G Engelhardt, Wichai Chinratanalab, Salyka Sengsayadeth, Stephen J. Brandt, Stacey A. Goodman, John P. Greer, Madan Jagasia, Bipin N. Savani
Journal: Blood (2016)
Cautious Interpretation of Observational Data—Reply
Authors: Katharine E. Harding, Emma C. Tallantyre, Neil P. Robertson
Journal: JAMA Neurology (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Targeting the Mammalian Mitochondrial Clpp (mClpP) As a Novel Therapeutic Strategy for Acute Myeloid Leukemia
Authors: Alicia Cole, Zezhou Wang, Rachel Mattson, Rose Hurren, Fengshu Lin, Marcela Gronda, Neil Maclean, Methvin Isaac, Elisa Leung, Mohan Babu, Mahadeo A. Sukhai, Walid A. Houry, Aaron D. Schimmer
Journal: Blood (2012)
Positive Impact of Chronic Graft-Versus Host Disease on Survival in 928 Allogeneic Hematopoietic Stem Cell Transplant Recipients
Authors: Gunhan Gurman, Pinar Ataca, Erden Atilla, Sinem Civriz Bozdag, Selami Kocak Toprak, Meltem Kurt Yuksel, Taner Demirer, Hamdi Akan, Onder Arslan, Pervin Topcuoglu, Meral Beksac, Osman Ilhan, Muhit Ozcan
Journal: Blood (2015)
Phase I/II Clinical Trial of CpG-Activated Whole Cell Vaccine in Mantle Cell Lymphoma (MCL): Results in Safety and Efficacy from Planned Interim Analysis
Authors: Michael P. Chu, Joshua Brody, Holbrook E Kohrt, Matthew J. Frank, Michael Khodadoust, Sunil Reddy, Ranjana H Advani, Neel K. Gupta, Ginna Laport, Lauren S Maeda, Everett Meyer, David B. Miklos, Robert Negrin, Andrew R. Rezvani, Wen-Kai Weng, Kevin Sheehan, Malek Faham, Debra K Czerwinski, Ami Okada, Ronald Levy
Journal: Blood (2015)
Sporadic Bloody Diarrhea-Associated Thrombotic Thrombocytopenic Purpura-Hemolytic Uremic Syndrome (TTP-HUS) in Adults in Oklahoma: Comparison to Adults with Severe Adamts13 Deficiency and to Children with Typical HUS.
Authors: Loan Nguyen, Charity A. Karpac, Johanna A. Kremer Hovinga, Bernhard Lämmle, Deirdra R. Terrell, Sara K. Vesely, James N. George
Journal: Blood (2007)
Detecting the impact of subject characteristics on machine learning-based diagnostic applications
Authors: Elias Chaibub Neto, Abhishek Pratap, Thanneer M. Perumal, Meghasyam Tummalacherla, Phil Snyder, Brian M. Bot, Andrew D. Trister, Stephen H. Friend, Lara Mangravite, Larsson Omberg
Journal: npj Digital Medicine (2019)

Collection of high-dimensional, longitudinal digital health data has the potential to support a wide-variety of research and clinical applications including diagnostics and longitudinal health tracking. Algorithms that process these data and inform digital diagnostics are typically developed using training and test sets generated from multiple repeated measures collected across a set of individuals. However, the inclusion of repeated measurements is not always appropriately taken into account in the analytical evaluations of predictive performance. The assignment of repeated measurements from each individual to both the training and the test sets ("record-wise" data split) is a common practice and can lead to massive underestimation of the prediction error due to the presence of "identity confounding." In essence, these models learn to identify subjects, in addition to diagnostic signal. Here, we present a method that can be used to effectively calculate the amount of identity confounding learned by classifiers developed using a record-wise data split. By applying this method to several real datasets, we demonstrate that identity confounding is a serious issue in digital health studies and that record-wise data splits for machine learning- based applications need to be avoided.
Incidence and Outcome of Bacterial Blood Stream Infections in Allotransplanted Patients: Rethinking the Role of Fluoroquinolone Prophylaxis
Authors: Benedetta Rambaldi, Michele Malagola, Giuseppe Ravizzola, Giorgio Giannetta, Nicola Polverelli, Cristina Skert, Alessandro Turra, Valeria Cancelli, Federica Cattina, Francesca Schieppati, Arnaldo Caruso, Domenico Russo
Journal: Blood (2016)
Prediabetes and Risk for Cardiovascular Disease by Hypertension Status in Black Adults: The Jackson Heart Study
Authors: Demetria Hubbard, Lisandro D. Colantonio, Rikki M. Tanner, April P. Carson, Swati Sakhuja, Byron C. Jaeger, Robert M. Carey, Laura P. Cohen, Daichi Shimbo, Mark Butler, Alain G. Bertoni, Aisha T. Langford, John N. Booth, Jolaade Kalinowski, Paul Muntner
Journal: Diabetes Care (2019)

OBJECTIVE Recent studies have suggested that prediabetes is associated with an increased risk for cardiovascular disease (CVD) only among individuals with concomitant hypertension. RESEARCH DESIGN AND METHODS We analyzed the association between prediabetes and CVD by hypertension status among 3,313 black adults in the Jackson Heart Study (JHS) without diabetes or a history of CVD at baseline (2000–2004). Prediabetes was defined as fasting plasma glucose between 100 and 125 mg/dL or hemoglobin A1c between 5.7 and 6.4% (39 and 46 mmol/mol). Hypertension was defined as systolic/diastolic blood pressure ≥140/90 mmHg and/or self-reported antihypertensive medication use. Participants were followed for incident CVD events and all-cause mortality through 31 December 2014. RESULTS Overall, 35% of JHS participants did not have prediabetes or hypertension, 18% had prediabetes alone, 22% had hypertension alone, and 25% had both prediabetes and hypertension. Compared with participants without either condition, the multivariable-adjusted hazard ratios for CVD events among participants with prediabetes alone, hypertension alone, and both prediabetes and hypertension were 0.86 (95% CI 0.51, 1.45), 2.09 (1.39, 3.14), and 1.93 (1.28, 2.90), respectively. Among participants with and without hypertension, there was no association between prediabetes and an increased risk for CVD (0.78 [0.46, 1.34] and 0.94 [0.70, 1.26], respectively). No association was present between prediabetes and all-cause mortality among participants with or without hypertension. CONCLUSIONS Regardless of hypertension status, prediabetes was not associated with an increased risk for CVD or all-cause mortality in this cohort of black adults.
Design and Application of a Novel PNA Probe for the Detection At Single Cell Level of JAK2V617F Mutation
Authors: Daniela Cilloni, Valentina Rosso, Davide Torti, Francesca Carnuccio, Anna Serra, Paolo Nicoli, Valentina Gaidano, Valentina Campia, Elisabetta Signorino, Chiara Calabrese, Sonia Carturan, Alessandra Favole, Giuseppe Saglio, Francesco Frassoni, Enrico Bracco
Journal: Blood (2012)
Deleterious Roles of the KIR Ligand Mismatch on Acute Graft Versus Host Disease in Unmanipulated HLA-Mismatched/Haploidentical Blood and Marrow Transplantation.
Authors: Xiao Jun Huang, Xiang Yu Zhao, Dai Hong Liu, Kai Yan Liu, Lan Ping Xu, Yu Hong Chen, Wei Han
Journal: Blood (2006)
Reduced Intensity Conditioning (RIC) Allogeneic Stem Cell Transplantation (allo-SCT) for Patients with Acute Myeloid Leukemia (AML): Long Term Results of a “Donor” Versus “No Donor” Comparison.
Authors: Mohamad Mohty, Hugues de Lavallade, Jean El-Cheikh, Patrick Ladaique, Catherine Faucher, Sabine Furst, Norbert Vey, Diane Coso, Anne-Marie Stoppa, Jean-Albert Gastaut, Christian Chabannon, Didier Blaise
Journal: Blood (2007)
100% of Complete Response (CR) and Survival (FFP, OS) in Newly Diagnosed Patients with Advanced- and Intermediate-Stage Hodgkin’s Lymphoma (HL) Treated with Six Cycles of Dose-Dense, Dose-Intense (DD-DI) ABVD without Radiotherapy (RT).
Authors: Filippo Russo, Gaetano Corazzelli, Ferdinando Frigeri, Secondo LaStoria, Antonio Pinto
Journal: Blood (2006)
Precision Oncology for Pancreatic Cancer across the United States: the Know Your Tumor ® experience
Authors: Lynn M. Matrisian, Edik M. Blais, Emily Lyons, Cassadie Moravek, Patricia Dearbeloa, Subha Madhavan, Jonathan R. Brody, Emanuel Petricoin, Michael J. Pishvaian
Journal: Annals of Oncology (2019)
Genetic Polymorphisms in the Inflammasomes Are Associated with Relapse and Survival in HLA-Identical Sibling Donor Allogeneic Stem Cell Transplantation.
Authors: Miquel Granell, Alvaro Urbano-Ispizua, Aina Pons, Juan Ignacio Arostegui, Alfons Navarro, Sonia Jansa, Rosa Artells, Anna Gaya, Francesc Fernandez-Aviles, Carmen Martinez, Montserrat Rovira, Enric Carreras, Jordi Yague, Emili Montserrat, Mariano Monzo
Journal: Blood (2007)
Piperlongumine Blocks JAK2-STAT3 Pathway to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species
Authors: Hengjie Yuan, Katie Houck, Ye Tian, Zhou Zhou, Mingzhao Zhu, Vimal Patel, Uddalak Bharadwaj, David John Tweardy, Daniel Romo, Xiaoyun Fu, Yanjun Zhang, Jianning Zhang, Jing-fei Dong
Journal: Blood (2014)
PGC1α Suppresses Prostate Cancer Cell Invasion through ERRα Transcriptional Control
Authors: Lorea Valcarcel-Jimenez, Alice Macchia, Eva Crosas-Molist, Ariane Schaub-Clerigué, Laura Camacho, Natalia Martín-Martín, Paolo Cicogna, Cristina Viera-Bardón, Sonia Fernández-Ruiz, Irene Rodriguez-Hernandez, Ivana Hermanova, Ianire Astobiza, Ana R. Cortazar, Jon Corres-Mendizabal, Antonio Gomez-Muñoz, Victoria Sanz-Moreno, Verónica Torrano, Arkaitz Carracedo
Journal: Cancer Research (2019)

Abstract The PPARγ coactivator 1 alpha (PGC1α) is a prostate tumor suppressor that controls the balance between anabolism and catabolism. PGC1A downregulation in prostate cancer is causally associated with the development of metastasis. Here we show that the transcriptional complex formed by PGC1α and estrogen-related receptor 1 alpha (ERRα) controls the aggressive properties of prostate cancer cells. PGC1α expression significantly decreased migration and invasion of various prostate cancer cell lines. This phenotype was consistent with remarkable cytoskeletal remodeling and inhibition of integrin alpha 1 and beta 4 expression, both in vitro and in vivo. CRISPR/Cas9-based deletion of ERRα suppressed PGC1α regulation of cytoskeletal organization and invasiveness. Mechanistically, PGC1α expression decreased MYC levels and activity prior to inhibition of invasiveness. In addition, PGC1α and ERRα associated at the MYC promoter, supporting the inhibitory activity PGC1α. The inverse correlation between PGC1α–ERRα activity and MYC levels was corroborated in multiple prostate cancer datasets. Altogether, these results support that PGC1α–ERRα functions as a tumor-suppressive transcriptional complex through the regulation of metabolic and signaling events. Significance: These findings describe how downregulation of the prostate tumor suppressor PGC1 drives invasiveness and migration of prostate cancer cells.
A 6-Lncrna Scoring System for Prognostication of Adult Myelodysplastic Syndromes
Authors: Chi-Yuan Yao, Ching-Hsuan Chen, Whai-Shuan Huang, Hsin-An Hou, Chien-Chin Lin, Mei-Hsuan Tseng, Chein-Jun Kao, Tzu-Pin Lu, Wen-Chien Chou, Hwei-Fang Tien
Journal: Blood (2016)
Ibrutinib Inhibits B-Cell Adhesion and Causes An Efflux Of Chronic Lymphocytic Leukemia Cells From The Tissue Microenvironment Into The Blood Leading To a Transient Treatment-Induced Lymphocytosis
Authors: Rashida Z Mustafa, Sarah E. M. Herman, Jade Jones, Jennifer Gyamfi, Mohammed Farooqui, Adrian Wiestner
Journal: Blood (2013)
Results of a Phase II of Low-Dose Fludarabine and Cyclophosphamide Combined with Standard Dose Rituximab (FCR-LITE) in Elderly, Untreated Patients with Chronic Lymphocytic Leukemia (CLL): The Israeli CLL Study Group Experience
Authors: Tamar Tadmor, Yair Herishanu, Andrei Braester, Osnat Bairey, Ariel Aviv, Naomi Rahimi-Levene, Riva Fineman, Itai Levi, Mona Yuklea, Rosa Ruchlemer, Lev Shvidel, Aaron Polliack
Journal: Blood (2018)
Distinct Differences in in Vitro Erythroid Proliferation and Differentiation, p53 and Apoptosis Pathways in Diamond-Blackfan Anemia in Conjunction with Depletion of RPS19, RPL5 and RPL11 mRNA.
Authors: Hélène Moniz, Corinne Hurtaud, Thierry Leblanc, Gil Tchernia, Narla Mohandas, Lydie Da Costa
Journal: Blood (2009)