<i>Candida auris</i>: An Emerging Antimicrobial Resistance Threat
Authors: Snigdha Vallabhaneni, Brendan R. Jackson, Tom M. Chiller
Journal: Annals of Internal Medicine (2019)

Ideas and Opinions17 September 2019Candida auris: An Emerging Antimicrobial Resistance ThreatSnigdha Vallabhaneni, MD, MPH, Brendan R. Jackson, MD, MPH, and Tom M. Chiller, MD, MPHTMSnigdha Vallabhaneni, MD, MPHCenters for Disease Control and Prevention, Atlanta, Georgia (S.V., B.R.J., T.M.C.), Brendan R. Jackson, MD, MPHCenters for Disease Control and Prevention, Atlanta, Georgia (S.V., B.R.J., T.M.C.), and Tom M. Chiller, MD, MPHTMCenters for Disease Control and Prevention, Atlanta, Georgia (S.V., B.R.J., T.M.C.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/M19-2205 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Candida auris is becoming a household name—no easy feat for a fungus. This multidrug-resistant yeast, first reported in 2009 after it was found in the ear canal of a patient in Japan, has since caused invasive infections in more than 30 countries spanning every inhabited continent (1). It is an urgent threat because many strains are resistant to at least 2 of the 3 major classes of antifungal drugs used to treat Candida infections and because it causes outbreaks in health care settings to an extent not seen with other Candida species.Despite its name, C auris more commonly causes ...References1. Centers for Disease Control and Prevention. Candida auris. 2019. Accessed at www.cdc.gov/fungal/candida-auris/index.html on 17 July 2019. Google Scholar2. Vallabhaneni S, Kallen A, Tsay S, et al; MSD. Investigation of the first seven reported cases of Candida auris, a globally emerging invasive, multidrug-resistant fungus — United States, May 2013–August 2016. MMWR Morb Mortal Wkly Rep. 2016;65:1234-7. [PMID: 27832049] doi:10.15585/mmwr.mm6544e1 CrossrefMedlineGoogle Scholar3. Govender NP, Magobo RE, Mpembe R, et al. Candida auris in South Africa, 2012–2016. Emerg Infect Dis. 2018;24:2036-40. [PMID: 30334713] doi:10.3201/eid2411.180368 CrossrefMedlineGoogle Scholar4. Forsberg K, Woodworth K, Walters M, et al. Candida auris: the recent emergence of a multidrug-resistant fungal pathogen. Med Mycol. 2019;57:1-12. [PMID: 30085270] doi:10.1093/mmy/myy054 CrossrefMedlineGoogle Scholar5. Eyre DW, Sheppard AE, Madder H, et al. A Candida auris outbreak and its control in an intensive care setting. N Engl J Med. 2018;379:1322-31. [PMID: 30281988] doi:10.1056/NEJMoa1714373 CrossrefMedlineGoogle Scholar6. Adams E, Quinn M, Tsay S, et al; Candida auris Investigation Workgroup. Candida auris in healthcare facilities, New York, USA, 2013–2017. Emerg Infect Dis. 2018;24:1816-24. [PMID: 30226155] doi:10.3201/eid2410.180649 CrossrefMedlineGoogle Scholar7. Southwick K, Adams EH, Greenko J, et al. New York State 2016–2018: progression from Candida auris colonization to bloodstream infection. Open Forum Infect Dis. 2018;5 Suppl 1 S594-5. doi:10.1093/ofid/ofy210.1695 CrossrefGoogle Scholar8. Kerins JL, Tang AS, Forsberg K, et al. Rapid emergence of Candida auris in the Chicago region. Open Forum Infect Dis. 2018;5 Suppl 1 S28. doi:10.1093/ofid/ofy209.064 CrossrefGoogle Scholar9. Brooks R, Walters M, Forsberg K, et al. Candida auris in a patient with carbapenemase-producing organisms and recent hospitalization in Kenya. MMWR Morb Mortal Wkly Rep. 2019. [Forthcoming]. Google Scholar Author, Article, and Disclosure InformationAffiliations: Centers for Disease Control and Prevention, Atlanta, Georgia (S.V., B.R.J., T.M.C.)Acknowledgment: The authors thank Dr. Sharon Tsay, Ms. Kaitlin Forsberg, Dr. Maroya Walters, Dr. Alex Kallen, Dr. Nimalie Stone, and Dr. Melissa Schaefer for reviewing the document.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M19-2205.Corresponding Author: Snigdha Vallabhaneni, MD, MPH, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329; e-mail, [email protected]gov.Current Author Addresses: Drs. Vallabhaneni, Jackson, and Chiller: Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329.Author Contributions: Conception and design: S. Vallabhaneni, B.R. Jackson.Drafting of the article: S. Vallabhaneni, B.R. Jackson.Critical revision of the article for important intellectual content: S. Vallabhaneni, B.R. Jackson.Final approval of the article: S. Vallabhaneni, B.R. Jackson, T.M. Chiller.This article was published at Annals.org on 30 July 2019. 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