tbuckley/cabot-search huggingface dataset:
Energy conservation technique improves dyspnoea when patients with severe COPD climb stairs: a randomised crossover study
Authors: Guillaume Prieur, Yann Combret, Clement Medrinal, Nathalie Arnol, Tristan Bonnevie, Francis-Edouard Gravier, Jean Quieffin, Bouchra Lamia, Gregory Reychler, Jean-Christian Borel
Journal: Thorax (2020)

In this randomised, crossover trial, 22 patients with severe chronic obstructive pulmonary disease climbed six flights of stairs (108 steps) twice, under two test conditions: (1) energy conservation technique (ECT): participants were asked to rest for at least 5 seconds every three steps and (2) control condition: participants climbed the stairs at their own pace. Significant lower dyspnoea (primary outcome), leg discomfort, minute ventilation and capillary blood lactate under the ECT condition were found, with no change in total task time. Clinical trial registration NCT03564028
miR-181aとmiR-630はシスプラチン誘発癌細胞死を制御する
Authors: Galluzzi Lorenzo, Morselli Eugenia, Vitale Ilio, Kepp Oliver, Senovilla Laura, Criollo Alfredo, Servant Nicolas, Paccard Caroline, Hupe Philippe, Robert Thomas, Ripoche Hugues, Lazar Vladimir, Harel-Bellan Annick, Dessen Philippe, Barillot Emmanuel
Journal: Cancer Research (2010)
Lurbinectedin as second-line treatment for patients with small-cell lung cancer: a single-arm, open-label, phase 2 basket trial
Authors: José Trigo, Vivek Subbiah, Benjamin Besse, Victor Moreno, Rafael López, María Angeles Sala, Solange Peters, Santiago Ponce, Cristian Fernández, Vicente Alfaro, Javier Gómez, Carmen Kahatt, Ali Zeaiter, Khalil Zaman, Valentina Boni, Jennifer Arrondeau, Maite Martínez, Jean-Pierre Delord, Ahmad Awada, Rebecca Kristeleit, Maria Eugenia Olmedo, Luciano Wannesson, Javier Valdivia, María Jesús Rubio, Antonio Anton, John Sarantopoulos, Sant P Chawla, Joaquín Mosquera-Martinez, Manolo D'Arcangelo, Armando Santoro, Victor M Villalobos, Jacob Sands, Luis Paz-Ares
Journal: The Lancet Oncology (2020)
Telacebec (Q203), a New Antituberculosis Agent
Authors: Veronique R de Jager, Rodney Dawson, Christo van Niekerk, Jane Hutchings, Jeongjun Kim, Naadira Vanker, Lize van der Merwe, Jinho Choi, Kiyean Nam, Andreas H Diacon
Journal: New England Journal of Medicine (2020)

confirmed the results.In addition, the isolation of SARS-CoV-2 from both samples in cell culture of Caco-2 cells indicated potential infectivity (see the Supplementary Appendix, available with the full text of this letter at NEJM.org).These two persons were subsequently isolated from the cohort and transferred to the Infectious Disease Unit at University Hospital Frankfurt for further evaluation and observation on the following day.After a thorough evaluation in the hospital ward, a faint rash and minimal pharyngitis were observed in one patient.Both patients remained well and afebrile 7 days after admission.In this effort to evacuate 126 people from Wuhan to Frankfurt, a symptom-based screening process was ineffective in detecting SARS-CoV-2 infection in 2 persons who later were found to have evidence of SARS-CoV-2 in a throat swab.We discovered that shedding of potentially infectious virus may occur in persons who have no fever and no signs or only minor signs of infection.
Interaction between residential greenness and air pollution mortality: analysis of the Chinese Longitudinal Healthy Longevity Survey
Authors: John S Ji, Anna Zhu, Yuebin Lv, Xiaoming Shi
Journal: The Lancet Planetary Health (2020)

BackgroundBoth air pollution and green space have been shown to affect health. We aimed to assess whether greenness protects against air pollution-related mortality.MethodsWe used data from the 2008 wave of the Chinese Longitudinal Healthy Longevity Survey. We calculated contemporaneous normalised difference vegetation index (NDVI) in the 500 m radius around each participant's residence. Fine particulate matter (PM2·5) concentration was calculated using 3-year average concentrations in 1 km × 1 km grid resolution. We used Cox proportional hazards models to estimate the effects of NDVI, PM2·5, and their interaction on all-cause mortality, adjusted for a range of covariates.FindingsThe cohort contained 12 873 participants, totalling 47 884 person-years. There were 7426 deaths between 2008 and 2014. The mean contemporaneous NDVI was 0·42 (SD 0·21), and the mean 3-year average PM2·5 was 49·63 μg/m3 (13·72). In the fully adjusted model, the mortality hazard ratio for each 0·1-unit decrease in contemporaneous NDVI was 1·08 (95% CI 1·03–1·13), each 10 μg/m3 increase in PM2·5 was 1·13 (1·09–1·18), and the interaction term was 1·01 (1·00–1·02) with a p value of 0·027. We observed non-linear associations in our stratified analyses: people living in urban areas were more likely to benefit from greenness, and people living in rural areas were more likely to be harmed by air pollution.InterpretationOur study showed some indication of a synergistic effect of greenness and air pollution, suggesting that green space planning and air pollution control can jointly improve public health.FundingBill & Melinda Gates Foundation, National Institutes of Health, National Key R&D Program of China, National Natural Science Foundation of China.
Abstract 11985: Prediction of Atherosclerotic Cardiovascular Disease Risk Using Machine Learning and Electronic Health Record Data
Authors: Andrew Ward, Ashish Sarraju, Sukyung Chung, Latha Palaniappan, David Scheinker, Fatima Rodriguez
Journal: Circulation (2019)

Background: Risk assessment is the cornerstone for guiding atherosclerotic cardiovascular disease (ASCVD) treatment decisions. Machine learning methods and electronic health record (EHR) data offer...
Abstract 15397: Classification, Investigation and Management of Patients With Myocardial Injury and Infarction: A Cross-Sectional Survey of Clinical Practice
Authors: Andrew R Chapman, Simran Piya, John Hung, Stacey Stewart, Marwa Daghem, Justin Chiong, Lucy Marshall, Amy Ferry, Fiona E Strachan, Marc Dweck, David E Newby, Nicholas L Mills
Journal: Circulation (2019)

Background: The Fourth Universal Definition states myocardial infarction may occur secondary to atherosclerotic plaque rupture or erosion (type 1) or due to myocardial oxygen supply or demand imbal...
Abstract P4-10-31: Patterns of protein expression and signaling assessed by reverse phase protein array (RPPA) in estrogen-receptor negative (ER-), HER2-amplified breast cancer (BC) that was primary-refractory to preoperative (preop) HER2-directed therapy
Authors: Mariaelena Pierobon, Maren K Levin, Elisa Baldelli, Leslie SL Kim, Lance Liotta, Emanuel F Petricoin, Joyce O'Shaughnessy
Journal: Cancer Research (2020)

Abstract Background: ER- HER2+ BC is comprised of a heterogeneous mix of intrinsic BC subtypes which have differential responsiveness to preop HER2-directed therapies combined with chemotherapy. Patients (pts) with ER- HER2+ BC whose disease progressed while on or who had no response to preop HER2-directed therapy are uncommon and the mechanisms of resistance within this primary-refractory disease are unknown. We utilized RPPA-based protein pathway activation mapping to map the drug target signaling architecture in pts’ primary-refractory ER- HER2+ BCs to begin to assess mechanisms of resistance. Methods: Eight primary-refractory ER- HER2+ FFPE BC tissues obtained from 5 pts (preop biopsies n=4 and/or post-treatment surgical resection n=4) underwent laser capture microdissection to isolate pure tumor epithelium followed by RPPA-based analysis of the levels and/or activation/phosphorylation of approximately 130 key signaling proteins known to be involved in tumorigenesis and metastatic progression. Results: Pts were all treated with preop trastuzumab, pertuzumab, docetaxel, and carboplatin (TCHP) with no response and/or with progression of disease. Three pts also received preop doxorubicin/cyclophosphamide without response. RPPA-based analysis revealed that post-TCHP surgical samples had higher activation of a number of drug targets including receptor tyrosine kinases (RTK) such as MET and ALK, as well as HER family signaling proteins phospho-HER3 and phospho-EGFR compared to the matched pre-TCHP samples. Conclusions: In these ER- HER2+ BCs that were primary-refractory to preop TCHP, in those pts with patient-matched pre/post treatment samples, activation of several potential resistance pathways such as alternative RKT signaling as well as EGFR and HER3 signaling was observed. These data are hypothesis-generating and require exploration in additional ER- HER2+ primary-refractory tissues. Citation Format: Mariaelena Pierobon, Maren K Levin, Elisa Baldelli, Leslie SL Kim, Lance Liotta, Emanuel F Petricoin, Joyce O'Shaughnessy. Patterns of protein expression and signaling assessed by reverse phase protein array (RPPA) in estrogen-receptor negative (ER-), HER2-amplified breast cancer (BC) that was primary-refractory to preoperative (preop) HER2-directed therapy [abstract]. In: Proceedings of the 2019 San Antonio Breast Cancer Symposium; 2019 Dec 10-14; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(4 Suppl):Abstract nr P4-10-31.
Sex Differences in Ischemic Heart Disease—the Paradox Persists
Authors: Rodrigo Mendirichaga, Alice K. Jacobs
Journal: JAMA Cardiology (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Minimal invasive living donor right hepatectomy: An experience of consecutive 114 cases by a single surgeon
Authors: Sang Hyun Kang, Dong Hwan Jung, Hwui Dong Cho, Shin Hwang, Ki Hun Kim, Chul Soo Ahn, Deok Bog Moon, Gi Won Song, Gil Chun Park, Young In Yoon
Journal: International Journal of Surgery (2020)
Translating evidence-based practice to clinical practice in Tokyo 2020: how to diagnose and manage exertional heat stroke
Authors: Yuri Hosokawa, Douglas J Casa, Sebastien Racinais
Journal: British Journal of Sports Medicine (2020)

Elite athletes competing at high-intensity in the hot and humid ambient conditions of the upcoming Games of the XXXII Olympiad (Tokyo 2020) are likely to reach elevated core temperature (≈41.5°C) as previously reported in elite competitions in the heat and the risk of exertional heat stroke (EHS) is heightened.1 EHS is a medical condition defined as an internal body temperature exceeding 40.5°C with central nervous system dysfunction (eg, disorientation, aggressiveness, hysteria, delirium, altered consciousness, irrational behaviour).2 3

Survival and sequela from EHS depend on the duration of hyperthermia.4 In 2020, evidence-based consensus suggests whole-body cooling until 39°C within the first 30 min of collapse as the critical requirement to maximise patient outcome.2 3 5 Whole-body cold water immersion (CWI) was associated with 100% survival rate in 274 runners diagnosed with EHS over the 18 years of patients treated at the New Balance Falmouth Road Race, with average cooling rate of 0.22°C min–1.5 In a different study, CWI using circulated water controlled at 2°C demonstrated an average cooling rate of 0.35°C min–1.6

To achieve the clinical target, medical providers at Tokyo 2020 must:

1.  provide on-site assessment of …
Mitochondria-Endoplasmic Reticulum Contacts in Reactive Astrocytes Promote Vascular Remodeling
Authors: Jana Gӧbel, Esther Engelhardt, Patric Pelzer, Vignesh Sakthivelu, Hannah M. Jahn, Milica Jevtic, Kat Folz-Donahue, Christian Kukat, Astrid Schauss, Christian K. Frese, Patrick Giavalisco, Alexander Ghanem, Karl-Klaus Conzelmann, Elisa Motori, Matteo Bergami
Journal: Cell Metabolism (2020)
Future Research Suggestions for Multigene Testing in Unselected Populations
Authors: Inyoung Jun, Alyssa L. Berger, Lusine Yaghjyan
Journal: JAMA Oncology (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Recurrent sessile serrated adenoma invading the site of previous appendectomy effectively resected by endoscopic submucosal dissection with double-clip and rubber band traction
Authors: Borathchakra Oung, Jérémie Jacques, Jérôme Rivory, Rémi Systchenko, Thierry Ponchon, Mathieu Pioche
Journal: Endoscopy (2020)

Endoscopic submucosal dissection (ESD) became the treatment of choice for colorectal superficial neoplastic lesions larger than 25 mm to achieve complete and curative resection, avoiding unnecessary surgery [1]. Double-clip and rubber band traction (DCT-ESD) was demonstrated to be a useful tool for Western endoscopists, allowing a better, faster, and safer procedure [2]. Moreover, for challenging lesions such as those on the site of previous appendectomy, or recurrent lesions, DCT-ESD allowed a promising outcome as well [3] [4].
Multicohort analysis reveals baseline transcriptional predictors of influenza vaccination responses
Authors: Stefan Avey, Foo Cheung, Damian Fermin, Jacob Frelinger, Renaud Gaujoux, Raphael Gottardo, Purvesh Khatri, Steven H. Kleinstein, Yuri Kotliarov, Hailong Meng, Renan Sauteraud, Shai S. Shen-Orr, John S. Tsang, Francesco Vallania, Esperanza Anguiano, Jeanine Baisch, Nicole Baldwin, Robert B. Belshe, Tamara P. Blevins, Damien Chaussabel, Mark M. Davis, Erol Fikrig, Diane E. Grill, David A. Hafler, Evan Henrich, Samit R. Joshi, Susan M. Kaech, Rick B. Kennedy, Subhasis Mohanty, Ruth R. Montgomery, Ann L. Oberg, Gerlinde Obermoser, Inna G. Ovsyannikova, A. Karolina Palucka, Virginia Pascual, Greg Poland, Bali Pulendran, Ellis Reinherz, Albert C. Shaw, Barbara Siconolfi, Kenneth D. Stuart, Sui Tsang, Ikuyo Ueda, Jean Wilson, Heidi J. Zapata
Journal: Science Immunology (2017)

Annual influenza vaccinations are currently recommended for all individuals 6 months and older. Antibodies induced by vaccination are an important mechanism of protection against infection. Despite the overall public health success of influenza vaccination, many individuals fail to induce a substantial antibody response. Systems-level immune profiling studies have discerned associations between transcriptional and cell subset signatures with the success of antibody responses. However, existing signatures have relied on small cohorts and have not been validated in large independent studies. We leveraged multiple influenza vaccination cohorts spanning distinct geographical locations and seasons from the Human Immunology Project Consortium (HIPC) and the Center for Human Immunology (CHI) to identify baseline (i.e., before vaccination) predictive transcriptional signatures of influenza vaccination responses. Our multicohort analysis of HIPC data identified nine genes (
Abstract P3-03-04: Role of ABL kinase signaling in metastatic breast cancer colonization of the brain
Authors: Courtney Michelle McKernan, Ann M Pendergast
Journal: Cancer Research (2020)

Abstract Breast cancer brain metastasis (BCBM) occurs in approximately 50% of late-stage Human Epidermal Growth Factor Receptor 2-positive (HER2+) breast cancer patients. BCBM may result in cognitive decline and cranial neuropathies and is associated with a median survival rate of nine months. Current therapies for BCBM, such as whole brain radiation therapy, can enhance cognitive impairment while targeted therapies and chemotherapy are ineffective. Despite the increased patient survival due to HER2 targeted therapies, patients often relapse due to brain metastases. Recently, our laboratory has discovered a role for Abelson (Abl) family of tyrosine kinases, ABL1 and ABL2, in breast cancer metastasis. Evaluation of 279 HER2+ breast cancer patients demonstrates a correlation between high expression of ABL1 and decreased distant metastasis free survival. Expression of ABL1 and ABL2 increase in brain metastatic breast cancer cells compared to parental cells, suggesting a role for the Abl kinases in breast cancer brain metastasis. I have found that treatment with the allosteric Abl kinase inhibitor GNF5 decreases colonization of the brain by two distinct human HER2+ breast cancer cell lines. Increasing evidence suggests that HER2 is upregulated in breast cancer cells colonizing the brain and may interact with the brain microenvironment to promote outgrowth. Both pharmacologic and genetic inhibition of the Abl kinases decreases HER2 protein expression in brain metastatic HER2+ breast cancer cells, potentially ablating the cell’s ability to proliferate in the brain. These data support a role for Abl kinases in promoting colonization of the brain by breast cancer cells. Due to its blood-brain barrier penetrance and efficacy in pre-clinical mouse models, Abl kinase-specific allosteric inhibitors may provide a novel therapeutic strategy for HER2+ breast cancer brain metastasis. Citation Format: Courtney Michelle McKernan, Ann M Pendergast. Role of ABL kinase signaling in metastatic breast cancer colonization of the brain [abstract]. In: Proceedings of the 2019 San Antonio Breast Cancer Symposium; 2019 Dec 10-14; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(4 Suppl):Abstract nr P3-03-04.
Abstract ES2-3: Guiding selection of RT approach after lumpectomy
Authors: SF Shaitelman
Journal: Cancer Research (2020)

Abstract Level I evidence supports the usage of adjuvant radiation therapy following breast conserving surgery for early stage breast cancer. Historically, this was typically delivered using standard fractionation whole breast irradiation. We will review multicenter, randomized controlled trials that support the use of hypofractionation in this setting. More recent level I data has also demonstrated excellent local control with partial breast irradiation for select, early stage breast cancers. In this educational talk we will review the local control and toxicity data for partial breast irradiation. International guidelines on the use of hypofractionated whole breast irradiation and partial breast irradiation will be discussed. We will aim to provide a framework for decision making when electing radiation technique in this setting. Citation Format: SF Shaitelman. Guiding selection of RT approach after lumpectomy [abstract]. In: Proceedings of the 2019 San Antonio Breast Cancer Symposium; 2019 Dec 10-14; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(4 Suppl):Abstract nr ES2-3.
Anticoagulant Therapy for Venous Thromboembolism in Cancer
Authors: Agnes Y Y Lee
Journal: New England Journal of Medicine (2020)

Direct oral anticoagulants were introduced for the treatment for acute venous thromboembolism just over a decade ago. Unlike warfarin, these drugs are given in fixed doses and do not require laboratory monitoring of the anticoagulant effect. Although direct oral anticoagulants are similar to warfarin in efficacy, they are more convenient to use and are associated with a lower risk of major bleeding, particularly intracranial hemorrhage. These factors prompted a change in practice guidelines to recommend the use of direct oral anticoagulants as the first-line therapy over warfarin and transformed outpatient treatment for the majority of patients with acute venous thromboembolism.1 . . .
A Fine-Scale Genetic Map for Vervet Monkeys
Authors: Susanne P Pfeifer
Journal: Molecular Biology and Evolution (2020)

Abstract Despite its important biological role, the evolution of recombination rates remains relatively poorly characterized. This owes, in part, to the lack of high-quality genomic resources to address this question across diverse species. Humans and our closest evolutionary relatives, anthropoid apes, have remained a major focus of large-scale sequencing efforts, and thus recombination rate variation has been comparatively well studied in this group—with earlier work revealing a conservation at the broad- but not the fine-scale. However, in order to better understand the nature of this variation, and the time scales on which substantial modifications occur, it is necessary to take a broader phylogenetic perspective. I here present the first fine-scale genetic map for vervet monkeys based on whole-genome population genetic data from ten individuals and perform a series of comparative analyses with the great apes. The results reveal a number of striking features. First, owing to strong positive correlations with diversity and weak negative correlations with divergence, analyses suggest a dominant role for purifying and background selection in shaping patterns of variation in this species. Second, results support a generally reduced broad-scale recombination rate compared with the great apes, as well as a narrower fraction of the genome in which the majority of recombination events are observed to occur. Taken together, this data set highlights the great necessity of future research to identify genomic features and quantify evolutionary processes that are driving these rate changes across primates.