tbuckley/cabot-search huggingface dataset:
THU-371-Modulation of H3K27 methylation by EZH2 and UTX/JMJD3 small molecules inhibitors impacts on proliferation and differentiation of hepatic progenitor cells and differentiated hepatocytes plasticity
Authors: Laura Belloni, Natalia Pediconi, Leonardo Lupacchini, Debora Salerno, Annapaola Angrisani, Giovanna Peruzzi, Enrico De Smaele, Massimo Levrero
Journal: Journal of Hepatology (2019)
Abstract 14184: Patients With Coronary Artery Disease and Bilateral Carotid Inflammation Show Higher One Year Rate of Cardiovascular Events
Authors: Georgios Benetos, Konstantinos Toutouzas, Maria Drakopoulou, Fotini Mitropoulou, Nikolaos Barampoutis, Iosif Koutagiar, Periklis Davlouros, Eleftherios Tsiamis, Elias Siores, Dimitrios Tousoulis
Journal: Circulation (2015)

Background: Inflammation is an essential characteristic of vulnerable atherosclerotic plaque. Although its prognostic value during invasive assessment has been documented, the clinical significance of its routine evaluation is still under dispute. Microwave radiometry (MWR) allows the rapid, in vivo, noninvasive assessment of the internal temperature of carotid arteries, reflecting local inflammation. The aim of the present study was to evaluate the prognostic role of carotid atherosclerotic plaque temperatures in patients with documented coronary artery disease (CAD). Methods: Consecutive patients with significant CAD as documented by coronary angiography were included in the study. All patients underwent evaluation of both carotid arteries by 1) ultrasound and 2) microwave radiometry (MWR). During ultrasound study maximum carotid plaque thickness was assessed in all carotids. Temperature difference (ΔT) by MWR was defined as maximal temperature along the carotid artery minus minimum. ΔT ≥0.90°C was assigned as high ΔT. Major cardiovascular event (MACE) was defined as death, stroke, myocardial infarction or revascularization. All patients were followed-up clinically for one year. Results: In total 192 patients were included in the study. At baseline thirty patients (15.6%) had high ΔT temperatures (≥0.90°C) in both carotid arteries. Max plaque thickness was slightly higher in this group (2.75±1.34 vs 2.27±1.03, p=0.07). MACE was 23.3% in the group with bilateral high ΔT and 4.3% in non-high ΔT group (p&lt;0.001). By multivariate logistic regression analysis, ΔT was an independent predictor for MACE, when adjusted for sex, age contemporary risk factors, number of vessels with significant stenosis and maximum carotid plaque thickness (OR: 6.10, 95% CI 1.56-23.80, p=0.001). In Kaplan-Meier plots patients with bilateral high ΔT showed higher event and mortality rates, compared with patients in non-high ΔT group (log-rank p=0.001 for both comparisons). Conclusion: The presence of bilateral high carotid artery temperatures as assessed by MWR has implications in short term prognosis of patients with CAD. A long term study is warranted to establish the prognostic impact of MWR in this high-risk population.
PS-169-Umbilical cords-derived mesenchymal stem cells ameliorated hepatocellular apoptosis mediated by PINK1-dependent mitophagy in liver ischemia/reperfusion injury dependent on AMPKα activation
Authors: Jun Zheng, Liang Chen, Jianye Cai, Jia Yao, Tongyu Lu, Xiaomei Zhang, Yingcai Zhang, Yang Yang
Journal: Journal of Hepatology (2019)
SAT-323-Selenoprotein P levels discriminate the degree of hepatic steatosis and are related to the NAS score in patients with non-alcoholic fatty liver disease
Authors: Chiara Rosso, Ramy Younes, Elisabetta Morello, Melania Gaggini, Gian Paolo Caviglia, Chiara Marinoni, Maria Jose Garcia Blanco, Antonella Olivero, Giorgio Maria Saracco, Amalia Gastaldelli, Antonina Smedile, Elisabetta Bugianesi
Journal: Journal of Hepatology (2019)
SAT-033-Body fat composition determines outcomes before and after liver transplantation in cirrhosis
Authors: Cornelius Engelmann, Stefan Schob, Ines Nonnenmacher, Luise Werlich, Jane Macnaughtan, Alexander Hung, Niklas Aehling, Adam Herber, Alexey Surov, Thorsten Kaiser, Rajiv Jalan, Daniel Seehofer, Michael Moche, Thomas Berg
Journal: Journal of Hepatology (2019)
Abstract 14184: Implantable Cardiac Devices: Are They Still a Contra-indication for Video Capsule Endoscopy in 2017?
Authors: Rabih Tabet, Najib Nassani, Boutros Karam, Philippe Akhrass, Liliane Deeb
Journal: Circulation (2017)

Introduction: To date, video capsule endoscopy (VCE) is still contra-indicated by the FDA in patients with implantable cardiac devices of any kind because of theoretical electro-magnetic interference and possible harm. This review assesses the safety profile of VCE in these patients, addresses the risk of interference and the potential outcomes. Methods: A systematic review of PubMed and Web of Science databases was conducted. Peer-reviewed articles containing “capsule endoscopy” AND “pacemaker, “defibrillator” OR “left ventricular assist device” as keywords were selected. Results: A total of 865 VCE procedures were performed in patients with cardiac devices in various clinical settings. Cardiac events were not seen in any case. Only 4 PPM switched to noise mode without consequences. Interference on capsule images transmission was noted in 6 cases (1 PPM, 5 LVAD) where few images were lost when the capsule was closest to the device. Finally, interference between capsule and telemetry leads was noted in 6 ...
TCTAP A-083 Long-term Clinical Outcomes in Patients with Untreated Non-culprit Intermediate Coronary Lesion and Evaluation of Predictors by Using Virtual Histology-Intravascular Ultrasound; A Prospective Cohort Study
Authors: Young Hoon Seo, Taek-Geun Kwon, Jang-Ho Bae
Journal: Journal of the American College of Cardiology (2019)
Potential of ultrasound scanning in oncodermatology.
Authors: Natalia A. Maksimova, Yury Valentinovich Przhedetsky, Victoria V. Pozdnyakova, Maria G. Ilchenko, Maria I. Kuryshova, Olga V. Khokhlova, Natalia A. Zakharova
Journal: Journal of Clinical Oncology (2015)

e20110 Background: Methodological aspects of modern technologies of ultrasound scanning (US) are still relevant in oncosurgery of skin cancer as there is need to clarify some parameters of tumor process for treatment strategy planning. The purpose of the study was to optimize US of patients with melanoma and skin cancer. Methods: Level of tumor invasion and vascularization, planning and performing of neoadjuvant local chemotherapy under ultrasound control, virtual simulation of excision volume in the modes of three-dimensional ultrasound reconstructions were assessed in 87 patients with melanoma. Search and marking of perforating vessels were made for plasty with island skin-fascial flaps in 15 patients with melanoma and 25 patients with squamous cell carcinoma of the skin of the lower extremities. US was performed with linear sensors (5-17 MHz) using “IU 22 PHILIPS” scanner in color flow mapping (CFM), power Doppler (PD) modes and the mode of three-dimensional ultrasound reconstructions (3D). Results: Breslow's depth was determined in melanoma patients with 91% accuracy using US. Multipronged design of 3D allowed performing of virtual computer personalized modeling of extended excision in melanoma with deep invasion in 25 patients. Parameters of CFM and PD allowed specifying the character of melanoma vascularization which was significant for the treatment optimization. Paratumoral local neoadjuvant chemotherapy was performed under ultrasound control to 68 patients with melanoma. The results of CFM and PD of patients with melanoma and squamous cell carcinoma of the skin of the lower extremities showed preference of plasty with skin flap on perforating vessels as improving functional performance and satisfactory aesthetic results in 92,9% of the cases in comparison with other methods (67,7%). Conclusions: Ultrasound scanning with the use of modern technologies plays an important role in diagnostics and planning treatment variants.
Clarifying the diagnosis of post-inflammatory pulmonary fibrosis: a population-based study
Authors: Ann Vu, Amit Vasireddy, Teng Moua, Misbah Baqir, Jay H. Ryu
Journal: European Respiratory Journal (2019)

<b>Patients with&nbsp;post-inflammatory pulmonary fibrosis were found to be&nbsp;a heterogeneous population, and the vast majority did not have IPF or any form of interstitial lung disease</b>http://bit.ly/2wcqepC
Establishing a new quality of life (QL) / patient reported outcome (PRO) / symptom scale in advanced cancer: Content validity for the “CSS” based on input from 3860 patients.
Authors: Julia Chia-Ying Shih, Prabal Chourasia, Richard J. Gralla, Pavlos Msaouel, Robert Sidlow, Patricia J Hollen
Journal: Journal of Clinical Oncology (2015)

9623 Background: Preserving or improving QL while managing symptoms are major goals in cancer care. To achieve these ends, the input of patients (pts) is mandatory as these are true PROs. The CSS (Cancer Symptom Scale) is a measure for pts with advanced cancer based on issues common to most malignancies; additionally, the CSS is designed to enhance patient input in late in life care settings such as hospice. While other measures exist, few if any are used in these settings routinely. The CSS is based on the model of the well-validated LCSS, and is planned to be a feasible and acceptable measure appropriate for use on an ePRO platform to minimize patient and caregiver burden. Methods: 50 cancer health care providers (HCPs) developed an initial list of issues to be evaluated by pts. This anonymous web-based survey used the resources of Nexcura.com and was then sent to pts to rate 18 to 21 issues on a 5 point scale ranging from “not important at all” to “very important (VI).” Results: Responses were given by 3,860 pts with: lung (660), breast (1072) and prostate (2128) cancer. 299 pts with advanced cancer had low performance status (KPS ≤60%) / stage IV extent. Results based on the top 2 categories (VI + important) of the leading 15 issues are listed below in the Table. Conclusions: 1) Responses from all 3860 pts are similar to those of the 299 with advanced disease, except for greater concern for pain and appetite in those with advanced cancer, and less importance for body image; 2) HCPs often rated items similarly to pts, but underestimated pt concern with concentration; and 3) the 5 items of greatest importance to patients are not symptoms but are items of global concern, and must be included in validated PRO measures. We believe this content validity survey for the CSS is the largest obtaining PROs from pts with cancer. % of All Patients (N max = 3860) % of Stage IV Patients (N max = 299) Quality of life 97 97 Concentration* 97 100 Independence 96 96 Ability to perform normal activities 95 93 Sleep 93 92 Fatigue 90 91 Dyspnea 83 80 Depression 82 78 Anxiety 78 74 Pain 77 83 Symptom distress 76 73 Diarrhea 69 66 Constipation 66 67 Appetite 66 76 Body image 65 44 * only tested in breast ca, and in 25 pts with advanced cancer.
Review: Some ED triage systems better predict ED mortality than in-hospital mortality or hospitalization
Authors: Thwe Htay, KoKo Aung
Journal: Annals of Internal Medicine (2019)

ACP Journal Club16 April 2019Review: Some ED triage systems better predict ED mortality than in-hospital mortality or hospitalizationThwe Htay, MD, KoKo Aung, MD, MPHThwe Htay, MDPaul L. Foster School of Medicine, El Paso, Texas, USA (T.H., K.A.)Search for more papers by this author, KoKo Aung, MD, MPHPaul L. Foster School of Medicine, El Paso, Texas, USA (T.H., K.A.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJ201904160-047 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationHinson JS, Martinez DA, Cabral S, et al. Triage performance in emergency medicine: a systematic review. Ann Emerg Med. 2018. [Epub ahead of print]. https://pubmed.ncbi.nlm.nih.gov/30470513Clinical Impact RatingsEmergency Med: References1 Nakao H, Ukai I, Kotani J. A review of the history of the origin of triage from a disaster medicine perspective. Acute Med Surg. 2017;4:379-84. [PMID: 29123897] Google Scholar2 Bullard MJ, Melady D, Emond M, et al. Guidance when applying the Canadian Triage and Acuity Scale (CTAS) to the geriatric patient: executive summary. CJEM. 2017;19:S28-S37. [PMID: 28756798] Google Scholar Author, Article, and Disclosure InformationAffiliations: Paul L. Foster School of Medicine, El Paso, Texas, USA (T.H., K.A.)This article was published at Annals.org on 2 April 2019. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAn external validation study of the Score for Emergency Risk Prediction (SERP), an interpretable machine learning-based triage score for the emergency departmentDevelopment and Assessment of an Interpretable Machine Learning Triage Tool for Estimating Mortality After Emergency Admissions 16 April 2019Volume 170, Issue 8Page: JC47KeywordsCohort studiesEmergency departmentHospitalizationsMortalityPopulation statisticsPulmonary embolismSepsisSystematic reviewsTriageVital signs ePublished: 16 April 2019 Issue Published: 16 April 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
SAT-220-Higher frequency of occult HCV infection in HIV/HCV coinfected patients with advanced liver disease: Post DAAs treatment observation
Authors: Sabrina Bagaglio, Emanuela Messina, Riccardo Vercesi, Giulia Morsica, Stefania Salpietro, Alba Bigoloni, Liviana Della Torre, Vinci Concetta, Adriano Lazzarin, Caterina Uberti-Foppa, Hamid Hasson
Journal: Journal of Hepatology (2019)
Longitudinal smoking patterns in survivors of childhood cancer: A Childhood Cancer Survivor Study (CCSS) update.
Authors: Todd M. Gibson, Wei Liu, Gregory T. Armstrong, Deo Kumar Srivastava, Melissa M. Hudson, Wendy M. Leisenring, Ann Mertens, Robert Klesges, Kevin C. Oeffinger, Paul C. Nathan, Leslie L. Robison
Journal: Journal of Clinical Oncology (2015)

10075 Background: Survivors of pediatric cancer have elevated risks of mortality and morbidity. Many morbidities associated with cancer treatment (e.g. second cancers, cardiac and pulmonary disease) are associated with cigarette smoking, suggesting survivors who smoke may be at higher risk for these adverse health conditions. Methods: We examined self-reported smoking status in 10,430 CCSS participants (age ≥ 18 years) across 2 questionnaires, at a median time of 7.9 years (range 1.4-11.9) apart. Smoking prevalence was compared among survivors, siblings, and the U.S. general population (standardized by age, sex, race/ethnicity and calendar time). Among a subgroup of survivors who also completed an additional follow-up questionnaire (N = 3908) a median of 12.5 years (range 4.3-16.3) after the first questionnaire, multivariable regression models evaluated characteristics associated with longitudinal smoking patterns. Results: At baseline, 19% of survivors were current smokers, compared with 24% of siblings and 29% in the standardized U.S. general population. At first follow-up, 17% of survivors were current smokers, compared to 21% of siblings and 24% of the U.S. population. Characteristics associated with consistent “never smoking” over all three questionnaires included higher household income (RR 1.17, 95% CI 1.08-1.25 for ≥ $60,000 versus < $20,000 per year), higher education (RR 1.36, 95% CI 1.26-1.47 for > high school versus ≤ high school), and receipt of cranial radiation therapy (RR 1.10, 95% CI 1.05-1.16). Among “ever smokers”, higher income (RR 1.22, 95% CI 1.09-1.38) and education (RR 1.26, 95% CI 1.13-1.40) were associated with quitting, whereas cranial radiation was associated with not having quit (RR 0.85, 95% CI 0.76-0.96). Development of an adverse health condition was not associated with smoking patterns. Conclusions: Although smoking prevalence may be declining, the substantial number of consistent, current smokers reinforces the need for continued development of effective smoking interventions for survivors.
Targeted next generation sequencing in well-differentated/dedifferentiated liposarcoma (WD/DD LPS): Multiple gene amplifications but few mutations.
Authors: Neeta Somaiah, Hannah Beird, Kenna Rael Shaw, Wei-Lien Wang, Anthony Paul Conley, Vinod Ravi, Keila E Torres, Davis Ingram, Christina Lynn Roland, Vivek Subbiah, Barry W. Feig, Alexander J. F. Lazar, Robert S. Benjamin, Shreyaskumar Patel, Patrick Hwu, Andrew Futreal, Funda Meric-Bernstam, David S. Hong
Journal: Journal of Clinical Oncology (2015)

10550 Background: WD/DD LPS is a common soft tissue sarcoma with approximately 1500 new cases per year. Surgery is the mainstay of treatment but recurrences are frequent and limited systemic options make treatment challenging. ‘Tumor genotyping’ is becoming more common in clinical practice as it offers the hope of personalized targeted therapy. We wanted to evaluate the results and the clinical utility of available tumor genotyping panels in WD/DD LPS. Methods: MDACC patients (pt) who had their tumor analyzed by either Foundation One (FM) (244 gene panel for solid tumors, tumor only) or the institutional T200 panel (202 gene panel, tumor and normal) were included. There were 124 overlapping genes in these panels. FFPE sections were sequenced on the T200 panel using the Illumina HiSeq2000 platform. On average, the cutoff for calling variants on the T200 is 1%-5% for high coverage data ( > 500x) and 10-15% for lower coverage( < 200x). Results: Total of 20 pt samples were identified, 7 on T200 (1 WD+6 DD) and 13 on FM (5 WD+8 DD). Significant copy number alterations (CNA) were identified in all samples. Only recurrent, potentially clinically actionable CNA (out of the 166 identified) are tabulated below. In the 7 pt samples on T200, 27 mutations were detected: 8 genes (CTNNB1, MECOM, ZNF536, EGFR, EML4, CSMD3, PBRM1, PPP1R3A) were identified as deleterious (on Condel, PolyPhen and SIFT) and a truncating mutation was found in NF2. Of these only the EGFR and NF2 are known driver mutations and potentially actionable. These mutations have not been reported previously in DD LPS. On the FM panel, ZNF536, CSMD3 and PPP1R3Awere not evaluated (NE) and no mutations were reported. Conclusions: In this series, 20/20 (100%) of the WD/DD LPS had MDM2 and CDK4amplified. Additional recurrent novel deleterious genetic changes were identified, but further studies are needed to determine their therapeutic and pathogenetic significance. High Amplification ( ≥ 4) Gene T200 +FISH N = 7 FM N = 13 Previously reported in DD LPS (50 samples in cbioportal) MDM2 7 13 Y (90%) CDK4 7 13 Y (88%) DDR1 2 NE N AURKB 2 0 N ERBB2 2 0 N FLT4 2 0 Y (2%) FGFR4 2 0 N MAP2K4 2 0 N NOTCH1 3 0 N NOTCH4 2 NE N AKT1 2 0 Y (4%) MCL1 NE 2 Y (10%) High Deletion 2 0 N BRCA2
Blood Pressure Measurement and Treatment Decisions
Authors: Kazuomi Kario, Lutgarde Thijs, Jan A. Staessen
Journal: Circulation Research (2019)

White-coat and masked hypertension are important hypertension phenotypes. Out-of-office blood pressure measurement is essential for the accurate diagnosis and monitoring of these conditions. This review summarizes literature related to the detection and diagnosis, prevalence, epidemiology, prognosis, and treatment of white-coat and masked hypertension. Cardiovascular risk in white-coat hypertension appears to be dependent on the presence of coexisting risk factors, whereas patients with masked hypertension are at increased risk of target organ damage and cardiovascular events. There is an unmet need for robust data to support recommendations around the use of antihypertensive treatment for the management of white-coat and masked hypertension.
THU-381-Characterization of regeneration in chronic hepatitis B before and after entecavir treatment in 20 patients
Authors: Ian Wanless, Bingqiong Wang, Yameng Sun, Hong You, Ji-Dong Jia, Shuyan Chen, Xiaoning Wu, Jialing Zhou, Xiaojuan Ou, Ashley Stueck
Journal: Journal of Hepatology (2019)
Assessing the Feasibility and Accuracy of High-resolution Microultrasound Imaging for Bladder Cancer Detection and Staging
Authors: Alberto Saita, Giovanni Lughezzani, Nicolò Maria Buffi, Rodolfo Hurle, Luciano Nava, Piergiuseppe Colombo, Pietro Diana, Vittorio Fasulo, Marco Paciotti, Grazia Maria Elefante, Massimo Lazzeri, Giorgio Guazzoni, Paolo Casale
Journal: European Urology (2019)
Risk of Engraftment Syndrome after Autologous Stem Cell Transplantation for Multiple Myeloma Increases with Age and Lower Dose of CD34+ Cells, but Is Not Impacted By Immunomodulatory Chemotherapy
Authors: Phyllis McKiernan, David Siegel, Scott D. Rowley, David H. Vesole, Tracy Andrews, Andrea Ortega, Alan P Skarbnik, Noa Biran, Joshua R Richter, Andrew L. Pecora, Andre Goy, Rima M Panchal, Nino Aleksidze, Michele L. Donato
Journal: Blood (2017)
The Long Noncoding RNA DNM3OS Is a Reservoir of FibromiRs with Major Functions in Lung Fibroblast Response to TGF-β and Pulmonary Fibrosis
Authors: Grégoire Savary, Edmone Dewaeles, Serena Diazzi, Matthieu Buscot, Nicolas Nottet, Julien Fassy, Elisabeth Courcot, Imène-Sarah Henaoui, Julie Lemaire, Nihal Martis, Cynthia Van der Hauwaert, Nicolas Pons, Virginie Magnone, Sylvie Leroy, Véronique Hofman, Laurent Plantier, Kevin Lebrigand, Agnès Paquet, Christian L. Lino Cardenas, Georges Vassaux, Paul Hofman, Andreas Günther, Bruno Crestani, Benoit Wallaert, Roger Rezzonico, Thierry Brousseau, François Glowacki, Saverio Bellusci, Michael Perrais, Franck Broly, Pascal Barbry, Charles-Hugo Marquette, Christelle Cauffiez, Bernard Mari, Nicolas Pottier
Journal: American Journal of Respiratory and Critical Care Medicine (2019)

Rationale: Given the paucity of effective treatments for idiopathic pulmonary fibrosis (IPF), new insights into the deleterious mechanisms controlling lung fibroblast activation, the key cell type driving the fibrogenic process, are essential to develop new therapeutic strategies. TGF-β (transforming growth factor-β) is the main profibrotic factor, but its inhibition is associated with severe side effects because of its pleiotropic role. Objectives: To determine if downstream noncoding effectors of TGF-β in fibroblasts may represent new effective therapeutic targets whose modulation may be well tolerated. Methods: We investigated the whole noncoding fraction of TGF-β-stimulated lung fibroblast transcriptome to identify new genomic determinants of lung fibroblast differentiation into myofibroblasts. Differential expression of the long noncoding RNA (lncRNA) DNM3OS (dynamin 3 opposite strand) and its associated microRNAs (miRNAs) was validated in a murine model of pulmonary fibrosis and in IPF tissue samples. Distinct and complementary antisense oligonucleotide-based strategies aiming at interfering with DNM3OS were used to elucidate the role of DNM3OS and its associated miRNAs in IPF pathogenesis. Measurements and Main Results: We identified DNM3OS as a fibroblast-specific critical downstream effector of TGF-β-induced lung myofibroblast activation. Mechanistically, DNM3OS regulates this process in trans by giving rise to three distinct profibrotic mature miRNAs (i.e., miR-199a-5p/3p and miR-214-3p), which influence SMAD and non-SMAD components of TGF-β signaling in a multifaceted way. In vivo, we showed that interfering with DNM3OS function not only prevents lung fibrosis but also improves established pulmonary fibrosis. Conclusions: Pharmacological approaches aiming at interfering with the lncRNA DNM3OS may represent new effective therapeutic strategies in IPF.