tbuckley/cabot-search huggingface dataset:
Air-conditioner cooling towers as complex reservoirs and continuous source of Legionella pneumophila infection evidenced by a genomic analysis study in 2017, Switzerland
Authors: Daniel Wüthrich, Sylvia Gautsch, Ruth Spieler-Denz, Olivier Dubuis, Valeria Gaia, Jacob Moran-Gilad, Vladimira Hinic, Helena MB Seth-Smith, Christian H. Nickel, Sarah Tschudin-Sutter, Stefano Bassetti, Monika Haenggi, Peter Brodmann, Simon Fuchs, Adrian Egli
Journal: Eurosurveillance (2019)

IntroductionWater supply and air-conditioner cooling towers (ACCT) are potential sources of Legionella pneumophila infection in people. During outbreaks, traditional typing methods cannot sufficiently segregate L. pneumophila strains to reliably trace back transmissions to these artificial water systems. Moreover, because multiple L. pneumophila strains may be present within these systems, methods to adequately distinguish strains are needed. Whole genome sequencing (WGS) and core genome multilocus sequence typing (cgMLST), with their higher resolution are helpful in this respect. In summer 2017, the health administration of the city of Basel detected an increase of L. pneumophila infections compared with previous months, signalling an outbreak.AimWe aimed to identify L. pneumophila strains populating suspected environmental sources of the outbreak, and to assess the relations between these strains and clinical outbreak strains.MethodsAn epidemiological and WGS-based microbiological investigation was performed, involving isolates from the local water supply and two ACCTs (n = 60), clinical outbreak and non-outbreak related isolates from 2017 (n = 8) and historic isolates from 2003-2016 (n = 26).ResultsIn both ACCTs, multiple strains were found. Phylogenetic analysis of the ACCT isolates showed a diversity of a few hundred allelic differences in cgMLST. Furthermore, two isolates from one ACCT showed no allelic differences to three clinical isolates from 2017. Five clinical isolates collected in the Basel area in the last decade were also identical in cgMLST to recent isolates from the two ACCTs.ConclusionCurrent outbreak-related and historic isolates were linked to ACCTs, which form a complex environmental habitat where strains are conserved over years.
Induction with Bortezomib Melphalan and Prednisolon (VMP) Is Associated with Unexpectedly High Discontinuation Rate in Elderly Multiple Myeloma Patients: First Analysis of the German Maintenance (GERMAIN) Trial
Authors: Annamaria Brioli, Kirsi Manz, Mathias Hänel, Markus Pfirrmann, Andreas Christoph Schwarzer, Marie von Lilienfeld-Toal, Gabriele Prange-Krex, Christian Fabisch, Stefan Knop, Thomas Illmer, Beate Krammer-Steiner, Andreas Hochhaus, Lars-Olof Mügge
Journal: Blood (2018)
Bortezomib, Lenalidomide and Dexamethasone (VRD-GEM) As Induction Therapy Prior Autologous Stem Cell Transplantation (ASCT) in Multiple Myeloma (MM): Results of a Prospective Phase III Pethema/GEM Trial
Authors: Laura Rosinol, Albert Oriol, Rafael Rios, Anna Sureda, M Jesús Blanchard, Miguel T Hernández, Rafael Martínez-Martínez, Jose M Moraleda, Isidro Jarque, Juan Bargay, Mercedes Gironella, Maria José Moreno, Luis Palomera, Yolanda Gonzalez-Montes, Josep M Marti, Isabel Krsnik, Jose M Arguiñano, Maria Esther González, Ana Pilar González, Felipe Casado, Lucía Lopez-Anglada, Bruno Paiva, Maria-Victoria Mateos, Jesus F. San Miguel, Juan-José Lahuerta, Joan Blade
Journal: Blood (2017)
The impact of neoadjuvant chemoradiation versus chemotherapy on short and long-term outcomes among gastric carcinoma patients.
Authors: Basem Azab, Francisco Igor Macedo, Omar Picado, Dido Franceschi, Alan S Livingstone, Danny Yakoub
Journal: Journal of Clinical Oncology (2019)

78 Background: There is little consensus on the use of neoadjuvant chemoradiation (NCRT) versus neoadjuvant chemotherapy (NCT) in gastric carcinoma (GC) patients. We sought to compare the outcomes of these two approaches in a large national data base. Methods: National Cancer Data Base PUF (2004-2014) of GC patients who underwent NCRT/NCT followed by resection were included. Primary outcome was overall survival (OS), secondary outcomes were pathological complete response (pCR), R0 resection and postoperative mortality. Results: A total of 4204 GC patients with NCT were included, 62% of them had additional neoadjuvant radiotherapy (NRT). NCRT had higher pCR and R0 rates [551/2613 (21%), 2314/2561 (90%)] than NCT group [148/1573 (9%), 1242/1543 (80%)], p &lt; 0.0001. Multivariate logistic regression showed similar higher odds of pCR (OR 2.8, 95% CI 1.65-4.60, p &lt; 0.0001) and R0 (OR 1.5, 95% CI 1.14-1.99, p = 0.004) among NCRT versus NCT. There was no significant difference in length of hospital stay, 30-day readmission rate, 30- and 90-day postoperative mortality. Median, 3- and 5-year OS for NCRT versus NCT were: (20.4 months, 24% and 11%) versus (18.3 months, 19% and 6%), p &lt; 0.001. Univariate cox regression analysis showed superior OS with NRT (HR 0.9, 95% CI 0.80-0.91, p &lt; 0.001). After adjusting for confounding variables, pCR (HR 0.2, 95% CI 0.18-0.24, p &lt; 0.001) and R0 (HR 0.7, 95% CI 0.61-0.75, p &lt; 0.001) had better OS, while NRT was not. Conclusions: NRT improved pCR and R0 rates in GC without increase in surgical morbidity/mortality. The long-term OS benefit of NRT is likely secondary to higher pCR and R0 resection.
Abstract 11154: Predictors of Improvement of Left Ventricular Diastolic Function After Transcatheter Aortic Valve Replacement in Severe Aortic Stenosis With Preserved Left Ventricular Systolic Function: A Serial Echocardiographic Study
Authors: Hiroto Utsunomiya, Hirotsugu Mihara, Yuji Itabashi, Javier Berdejo, Ken Matsuoka, Robert J Siegel, Kashif Mohammad, Hasanian Al-Jilaihawi, Raj R Makkar, Takahiro Shiota
Journal: Circulation (2014)

Background: Improvement of left ventricular (LV) diastolic function (DF) after transcatheter aortic valve replacement (TAVR) is not fully elucidated. The present serial transthoracic echocardiography study aimed to investigate the long-term clinical and hemodynamic impact of DF improvement after TAVR and to identify its predictors. Methods: We retrospectively reviewed echocardiographic and clinical data before and after TAVR in 98 patients with severe aortic stenosis (AS) and preserved LV systolic function. Mitral annular displacement was measured as the maximal distance of lateral annular motion during systole in apical 4-chamber view. DF was classified as grade 0 to 3 based on the recommendations of the American Society of Echocardiography. DF improvement was defined as ≥1 grade improvement at the 1-year follow-up. Results: Fifty-nine patients (60%) showed DF improvement. At baseline, patients with the improvement had a less severity of AS (valve area index, 0.37 ± 0.09 vs. 0.32 ± 0.08 cm2/m2) than those with no improvement. Despite similar baseline and changes in LV ejection fraction and mass index, the improvement group shows better recovery of functional status, stroke volume index, and E/e’ (Fig.1-3), as well as plasma brain natriuretic peptide level (median, 264 to 110 vs. 267 to 252 pg/ml, p = 0.017). When adjusting for age, demographic variables, valve area and change in mass index, absence of coronary artery disease (p = 0.03), mitral annular displacement (p &lt; 0.001), and right ventricular end-diastolic diameter (p = 0.02) were independently associated with DF improvement. A mitral annular displacement &gt;11.9 mm had a sensitivity of 83% and a specificity of 72% for prediction of DF improvement (Fig.4). Conclusion: DF improvement is often observed after TAVR and when present may be accompanied by more favorable clinical and hemodynamic changes. Mitral annular displacement, but not AS severity or degree of mass regression, predicts DF improvement after TAVR.
Impact of initial imaging with gallium-68 dotatate PET/CT on diagnosis and management of patients with neuroendocrine tumors (NETs): A sequential case series.
Authors: Hagen F. Kennecke, Preethi Raghu, Bruce Lin, Gayle L. Funk, Adnan Alseidi, Michal Hubka, Joseph G Rosales, Flavio G. Rocha, Marie E. Lee
Journal: Journal of Clinical Oncology (2019)

379 Background: Somatostatin analogue functional imaging with Ga-68 Dotatate PET/CT has demonstrated superiority in lesion detection in patients with NETs. The effect of this novel imaging modality on US clinical practice and its usefulness in different types of NETs is not well described. We describe the impact of initial NETSPOT imaging on diagnosis and management in NET patients at a large urban medical center. Methods: Consecutive patients diagnosed with NETs and referred to our institution who received an initial Ga-68 Dotatate PET/CT between 07/2017-09/2018 were included. Imaging was reviewed and compared to prior available CT, MRI, and/or In-111 Pentetreotide scans. Results: Among 101 patients, 51/50 were female/male, tumor origins were gastroenteropancreatic (GEP) (75%), Unknown Primary (UP) (13%), lung (8%), thymic (2%), and other (2%). All tumors were histologically well/moderately differentiated and 37/51/3/10 were G1/G2/G3/Unknown, respectively. Initial imaging with Ga-68 Dotatate PET/CT revealed additional metastatic disease in 37 of 77(48%) patients with prior evidence of metastatic disease. Most common sites were distant lymph nodes (18), bone (15) and liver (9), peritoneal/pleural (4). A previously UP tumor was identified in 3 patients. No patients with metastatic lung carcinoids (6 atypical, 2 typical) or thymic NETs (2 atypical/G2) NETs had evidence of Ga-68 Dota PET/CT uptake above reference liver SUV levels. Results of imaging altered patient management as follows: 14 initiated systemic therapy due to documentation of progression, in 6 surgical therapy was altered, in 4 biopsy/other management was changed. In 11 patients with no tumor Ga-68 Dotatate uptake, decisions about use of PRRT and somatostatin analogues was altered. Conclusions: In this series, Ga-68 Dotatate PET/CT altered diagnosis and management in 35/101 NET patients. Among GEP and UP NETs, Dotatate imaging diagnosed primarily new nodal, bone, liver and pleural/peritoneal metastases missed by other imaging modalities. Results support the routine use of Ga-68 Dotatate PET/CT in the care of patients with advanced and early stage NETS.
Genomic Landscape Impacts Induction Outcome with CPX-351 in Patients with Acute Myeloid Leukemia
Authors: Chetasi Talati, Aaron D Goldberg, Pinkal Desai, Onyee Chan, Christopher Famulare, Rami S. Komrokji, Andrew T Kuykendall, Hugo F. Fernandez, Yehuda E. Deutsch, Eric Padron, Alan F. List, Jeffrey E. Lancet, Gail J. Roboz, Martin S. Tallman, David A Sallman, Kendra L. Sweet
Journal: Blood (2018)
Cost-Effectiveness of Web-Based Patient-Reported Outcome Surveillance in Patients With Lung Cancer
Authors: Thibaut Lizée, Ethan Basch, Pierre Trémolières, Eric Voog, Julien Domont, Guillaume Peyraga, Thierry Urban, Jaafar Bennouna, Anne-Lise Septans, Magali Balavoine, Bruno Detournay, Fabrice Denis
Journal: Journal of Thoracic Oncology (2019)
New Cholesterol Guidelines Personalize Risk and Add Treatments
Authors: Jennifer Abbasi
Journal: JAMA (2019)

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Wire-guided stricturotomy for sealed ileal pouch
Authors: Freeha Khan, Bo Shen
Journal: Endoscopy (2019)

A 31-year-old woman with a 10-year history of ulcerative colitis was seen at our outpatient clinic with complaint of abdominal pain and increased output from her ileostomy. She had previously undergone a subtotal colectomy with an end ileostomy for medically refractory ulcerative colitis in 2008. She then underwent elective complete proctectomy with ileal pouch-anal anastomosis and diverting loop ileostomy 6 months later. We decided to perform pouchoscopy to rule out pouch-related complications ([Video 1]).
Relapse Risk and Loss in Expectation of Lifetime in Young Classical Hodgkin Lymphoma Patients - a Nordic Lymphoma Group Study of 2,582 Patients
Authors: Jorne Lionel Biccler, Ingrid Glimelius, Sandra Eloranta, Knut B. Smeland, Peter de Nully Brown, Lasse H. Jakobsen, Henrik Frederiksen, Mats Jerkeman, Alexander Fosså, Therese M.L. Andersson, Harald Holte, Martin Bøgsted, Tarec C. El-Galaly, Karin Ekstroem Smedby
Journal: Blood (2018)
Functional Cure, Defined As PFS of More Than 7 Years, Is Achieved in 9% of Myeloma Patients in the Era of Conventional Chemotherapy and of First-Generation Novel Anti-Myeloma Agents; A Single-Center Experience over 20-Year Period
Authors: Evangelos Terpos, Maria Roussou, Ioannis Ntanasis-Stathopoulos, Nikolaos Kanellias, Despina Fotiou, Dimitrios C. Ziogas, Aristea-Maria Papanota, Magdalini Migkou, Evangelos Eleutherakis-Papaiakovou, Maria Gavriatopoulou, Efstathios Kastritis, Meletios A Dimopoulos
Journal: Blood (2018)
P2-079: ERCC1 Expression by Immunohistochemistry and EGFR Mutations in Resected Non-Small Cell Lung Cancer
Authors: Kyung-Hun Lee, Hye Sook Min, Se-Hoon Lee, Dong-Wan Kim, Doo Hyun Chung, Young Tae Kim, Dae Seog Heo, Joo Hyun Kim, Sook Whan Sung
Journal: Journal of Thoracic Oncology (2007)
Incidence of metachronous gastric neoplasia after endoscopic submucosal dissection for gastric dysplasia.
Authors: Jae Gyu Kim, Jae Yong Park, Young-Il Kim
Journal: Journal of Clinical Oncology (2019)

20 Background: Endoscopic submucosal dissection (ESD) has been usually performed to treat gastric high-grade dysplasia (HGD) and selected lesions of low-grade dysplasia (LGD). However, HGD was classified into the same category of non-invasive carcinoma which were different from LGD in the Vienna classification of gastrointestinal epithelial neoplasia. We investigated whether the incidence of metachonous gastric neoplasia after ESD for gastric dysplasia is different between patients with LGD and HGD. Methods: Between March 2011 and December 2016, 508 patients underwent ESD for 545 gastric dysplasias or cancers at the Chung-Ang University Hospital. Of them, 198 patients with LGD (LGD group) and 46 with HGD (HGD group) who had been followed up for at least one year were included. The primary outcome was the incidence of gastric neoplasia occurred at 1-year follow-up or later after ESD. The secondary outcome was the composite incidence of metachronous HGD and gastric cancers. Results: During a median follow-up of 2.5 years, overall cumulative incidence of metachronous gastric neoplasm was 33.2 cases/1000 person-years. The metachronous neoplasms developed in 17 patients (8.6%; 11 LGD, 2 HGD and 4 gastric cancers) in the LGD group and in 6 patients (13.0%; 3 LGD, 1 HGD and 3 gastric cancers) in the HGD group. The incidence of metachronous gastric neoplasia in LGD group was not significantly different from that in HGD group (hazard ratio [HR] in the LGD group, 0.56; 95% confidence interval [CI], 0.22-1.43; P = 0.229). The composite incidences of metachronous HGD and gastric cancers were not also different between the two groups (HR for the composite incidences in the LGD group, 0.42; 95% CI, 0.10-1.68; P = 0.218). Conclusions: After ESD for gastric LGD, the incidence of metachronous gastric neoplasia was not different from that after ESD for HGD. Thus, similar surveillance strategies are needed for patients who underwent ESD for LGD and HGD.
Baseline and on-Treatment Bone Marrow Microenvironments Predict Myeloma Patient Outcomes and Inform Potential Intervention Strategies
Authors: Samuel A Danziger, Mark McConnell, Jake Gockley, Mary Young, Adam Rosenthal, Frank Schmitz, David Reiss, Phil Farmer, Cody Ashby, Michael A Bauer, Frits van Rhee, Faith E. Davies, Maurizio Zangari, Nathan Petty, Wilbert B. Copeland, Brian A. Fox, Antje Hoering, Alison Fitch, Katie Newhall, Bart Barlogie, Brian A Walker, Matthew Trotter, Rob Hershberg, Andrew Dervan, Alexander Ratushny, Gareth Morgan
Journal: Blood (2018)
Potential Long-Term Treatment of Hemophilia a By Early Postnatal Co-Transplantation of Cord Blood Derived Endothelial Colony-Forming Cells and Placental Mesenchymal Stem Cells
Authors: Kewa Gao, Priyadarsini Kumar, Dake Hao, Lizette Reynaga, Diana Lee Farmer, Melanie Rose, Jan A. Nolta, Jianda Zhou, Ping Zhou, Aijun Wang
Journal: Blood (2018)
Immune targets in the tumor microenvironment treated by radiotherapy
Authors: Omer M. Ozpiskin, Lu Zhang, Jian Jian Li
Journal: Theranostics (2019)

Radiotherapy (RT), the major anti-cancer modality for more than half of cancer patients after diagnosis, has the advantage of local tumor control with relatively less systematic side effects comparing to chemotherapy.However, the efficacy of RT is limited by acquired tumor resistance leading to the risks of relapse and metastasis.To further enhance the efficacy of RT, with the renaissances of targeted immunotherapy (TIT), increasing interests are raised on RT combined with TIT including cancer vaccines, T-cell therapy, and antibody-based immune checkpoint blockers (ICB) such as anti-CTLA-4 and anti-PD1/PD-L1.In achieving a significant synergy between RT and TIT, the dynamics of radiation-induced response in tumor cells and stromal cells, especially the cross-talk between tumor cells and immune cells in the irradiated tumor microenvironment (ITME) as highlighted in recent literature are to be elucidated.The abscopal effect refereeing the RT-induced priming function outside of ITME could be compromised by the immune-suppressive factors such as CD47 and PD-L1 on tumor cells and Treg induced or enhanced in the ITME.Cell surface receptors temporally or permanently induced and bioactive elements released from dead cells could serve antigenic source (radiation-associated antigenic proteins, RAAPs) to the host and have functions in immune regulation on the tumor.This review is attempted to summarize a cluster of factors that are inducible by radiation and targetable by antibodies, or have potential to be immune regulators to synergize tumor control with RT.Further characterization of immune regulators in ITME will deepen our understanding of the interplay among immune regulators in ITME and discover new effective targets for the combined modality with RT and TIT.
Randomized Trial in Unfit, Elderly Chronic Lymphocytic Leukemia (CLL) Patients with Comorbidities of Dose-Reduced Oral Fludarabine and Cyclophosphamide Plus Obinutuzumab (FC+G) Versus Chlorambucil Plus Obinutuzumab (Cbl+G) As Front-Line Therapy
Authors: Stephen P. Mulligan, Jane A. Freeman, Xavier Badoux, Richard Eek, Gavin Cull, Naomi J. Mackinlay, Nicholas E. Murphy, Duncan P. Carradice, Ann C. Solterbeck, Oliver Giles Best, Constantine S. Tam, Bryone J. Kuss
Journal: Blood (2018)
Phase 2 Trial of the Combination of Ixazomib, Thalidomide and Dexamethasone (ITD) in Relapsed/Refractory Myeloma: Planned Preliminary Analysis
Authors: Krystal Bergin, Flora Yuen, Craig Thomas Wallington-Beddoe, Anna Kalff, Shreerang Sirdesai, John Reynolds, Andrew Spencer
Journal: Blood (2018)
Simultaneous versus staged resection for synchronous colorectal cancer liver metastases: A population-based cohort study.
Authors: Jessica Bogach, Julian Wang, Sameer Parpia, Marko Simunovic, Julie I. Hallet, Pablo Emilio Serrano Aybar
Journal: Journal of Clinical Oncology (2019)

665 Background: While considered safe, simultaneous resection of colorectal cancer primary and liver metastases is not performed routinely. We aimed to identify practice patterns, short and long-term outcomes of simultaneous vs. staged resections for synchronous colorectal cancer liver metastases. Methods: We conducted a population-based cohort study of patients undergoing resection for synchronous colorectal cancer liver metastases from 2006-2015 by linking administrative healthcare datasets in Ontario, Canada. Resection of the primary colorectal cancer and liver metastases within six months was considered synchronous disease. Simultaneous (same hospital admission) and staged resections were compared. Outcomes were 90-day post-operative mortality, total length of hospital stay, overall survival and healthcare costs. Survival for the staged group was measured from the last surgical resection to death and estimated using Kaplan Meier. Cost analysis was undertaken from the perspective of a third-party payer and compared using t test. Results: Of 2,738 patients undergoing colorectal and liver resection for colorectal cancer, 1,168 were synchronous, of which, 442 underwent simultaneous resection. The rate of simultaneous resections increased on average by 3% per year (p = 0.02). Median total length of stay was shorter (8 vs. 11 days); 90-day post-operative mortality was higher for simultaneous resections (3.4% vs 1.2%). Median overall survival was worse with simultaneous resection (40 months, 95%CI 35-46 vs. 78 months, 95%CI 59-86), with a 5-year overall survival of 37% (simultaneous) and 55% (staged). Mean overall costs were lower for simultaneous resections ($12,722 CAD vs. $16,455 CAD. Conclusions: Simultaneous resection compared to staged resection for patients with synchronous colorectal cancer liver metastases is associated with higher 90-day postoperative mortality and worse survival. It was associated with shorter length of hospital stay and lower costs for the health cares system. Considering selection bias, randomized studies would be necessary to determine the role of simultaneous resection for synchronous disease colorectal cancer liver metastases.