tbuckley/cabot-search huggingface dataset:
Cangrelor, Tirofiban, and Chewed or Standard Prasugrel Regimens in Patients With ST-Segment–Elevation Myocardial Infarction
Authors: Giuseppe Gargiulo, Giovanni Esposito, Marisa Avvedimento, Michael Nagler, Pietro Minuz, Gianluca Campo, Felice Gragnano, Negar Manavifar, Raffaele Piccolo, Matteo Tebaldi, Plinio Cirillo, Lukas Hunziker, Pascal Vranckx, Sergio Leonardi, Dik Heg, Stephan Windecker, Marco Valgimigli
Journal: Circulation (2020)

Background: Standard administration of newer oral P2Y 12 inhibitors, including prasugrel or ticagrelor, provides suboptimal early inhibition of platelet aggregation (IPA) in patients with ST-segment–elevation myocardial infarction undergoing primary percutaneous coronary intervention. We aimed to investigate the effects of cangrelor, tirofiban, and prasugrel, administered as chewed or integral loading dose, on IPA in patients undergoing primary percutaneous coronary intervention. Methods: The FABOLUS-FASTER trial (Facilitation Through Aggrastat or Cangrelor Bolus and Infusion Over Prasugrel: A Multicenter Randomized Open-Label Trial in Patients with ST-Elevation Myocardial Infarction Referred for Primary Percutaneous Intervention) is an investigator-initiated, multicenter, open-label, randomized study. A total of 122 P2Y 12 -naive patients with ST-segment–elevation myocardial infarction were randomly allocated (1:1:1) to cangrelor (n=40), tirofiban (n=40) (both administered as bolus and 2-hour infusion followed by 60 mg of prasugrel), or 60-mg loading dose of prasugrel (n=42). The latter group underwent an immediate 1:1 subrandomization to chewed (n=21) or integral (n=21) tablets administration. The trial was powered to test 3 hypotheses (noninferiority of cangrelor compared with tirofiban using a noninferiority margin of 9%, superiority of both tirofiban and cangrelor compared with chewed prasugrel, and superiority of chewed prasugrel as compared with integral prasugrel, each with α=0.016 for the primary end point, which was 30-minute IPA at light transmittance aggregometry in response to 20 μmol/L adenosine diphosphate. Results: At 30 minutes, cangrelor did not satisfy noninferiority compared with tirofiban, which yielded superior IPA over cangrelor (95.0±8.9 versus 34.1±22.5; P &lt;0.001). Cangrelor or tirofiban were both superior to chewed prasugrel (IPA, 10.5±11.0; P &lt;0.001 for both comparisons), which did not provide higher IPA over integral prasugrel (6.3±11.4; P =0.47), despite yielding higher prasugrel active metabolite concentration (ng/mL; 62.3±82.6 versus 17.1±43.5; P =0.016). Conclusions: Cangrelor provided inferior IPA compared with tirofiban; both treatments yielded greater IPA compared with chewed prasugrel, which led to higher active metabolite concentration but not greater IPA compared with integral prasugrel. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT02978040; URL: https://www.clinicaltrialsregister.eu ; EudraCT 2017-001065-24.
Endoscopic “cutting” of a trapped Dormia basket
Authors: Andrea Tringali, Giovanna Margagnoni, Stefano Brighi, Guido Costamagna
Journal: Endoscopy (2020)

Mechanical lithotripsy is effective for removal of large bile duct stones during endoscopic retrograde cholangiopancreatography (ERCP) but is a complex procedure with a risk of complications [1]. The availability of alternative techniques to extract difficult stones (i. e. endoscopic papillary large balloon dilation [EPLBD] and cholangioscopy-assisted lithotripsy) [2] has resulted in a decline in the use of mechanical lithotripsy. Nevertheless, cholangioscopy-assisted lithotripsy is an advanced technique, not widely available, and is still expensive.
Global Hidradenitis Suppurativa COVID‐19 Registry: a registry to inform data‐driven management practices
Authors: H.B. Naik, R. Alhusayen, J. Frew, S. Guilbault, J.R. Ingram, M.A. Lowes, A.V. Marzano, M. Paul, B. Villumsen, C.A. Yannuzzi
Journal: British Journal of Dermatology (2020)

alveolar capillaries, 2 endothelial cells of kidney glomeruli, 3 brain blood vessels, 4 colonic mucosa 5 and skin. 6 Our immunohistochemical study represents a straightforward means of linking SARS-CoV-2 infection and endothelium.The presence of the virus in eccrine glands suggests sweat as a source of contagion, but this should be interpreted with caution.Given the similarities of SARS-CoV and SARS-CoV-2, it is worth mentioning that in a 2004 study of four autopsied patients with SARS, Ding et al. 7 found SARS-CoV nucleoprotein and RNA by immunohistochemistry and in situ hybridization, respectively, in a wide array of tissues, including sweat glands, intestine and kidney.They speculated accordingly the possibility of virus transmission through faeces, urine and sweat.A number of viruses, like hepatitis C virus, are known to replicate in sweat glands and keratinocytes; this could be investigated in sweat obtained by pilocarpine stimulation.
A Genomic Cluster Containing Novel and Conserved Genes is Associated with Cichlid Fish Dental Developmental Convergence
Authors: Nidal Karagic, Ralf F Schneider, Axel Meyer, C Darrin Hulsey
Journal: Molecular Biology and Evolution (2020)

The two toothed jaws of cichlid fishes provide textbook examples of convergent evolution. Tooth phenotypes such as enlarged molar-like teeth used to process hard-shelled mollusks have evolved numerous times independently during cichlid diversification. Although the ecological benefit of molar-like teeth to crush prey is known, it is unclear whether the same molecular mechanisms underlie these convergent traits. To identify genes involved in the evolution and development of enlarged cichlid teeth, we performed RNA-seq on the serially homologous-toothed oral and pharyngeal jaws as well as the fourth toothless gill arch of Astatoreochromis alluaudi. We identified 27 genes that are highly upregulated on both tooth-bearing jaws compared with the toothless gill arch. Most of these genes have never been reported to play a role in tooth formation. Two of these genes (unk, rpfA) are not found in other vertebrate genomes but are present in all cichlid genomes. They also cluster genomically with two other highly expressed tooth genes (odam, scpp5) that exhibit conserved expression during vertebrate odontogenesis. Unk and rpfA were confirmed via in situ hybridization to be expressed in developing teeth of Astatotilapia burtoni. We then examined expression of the cluster's four genes in six evolutionarily independent and phylogenetically disparate cichlid species pairs each with a large- and a small-toothed species. Odam and unk commonly and scpp5 and rpfA always showed higher expression in larger toothed cichlid jaws. Convergent trophic adaptations across cichlid diversity are associated with the repeated developmental deployment of this genomic cluster containing conserved and novel cichlid-specific genes.
Covid 19: Where’s the strategy for testing?
Authors: Fiona Godlee
Journal: BMJ (2020)

It would be nice to be able to say otherwise, but the UK's approach to testing in this covid-19 continues to be chaotic, centralised, commercialised, and driven by numerical targets rather than clear strategy.Allan Wilson, president of the Institute of Biomedical Sciences, has called this reactive and random approach the "wild west of testing." 1 Writing for BMJ Opinion this week, Chris Ham agrees.The system is far from "world beating," and ministers must be prepared to acknowledge and learn from mistakes, he says. 2at makes matters worse is the ongoing lack of honesty.The government has exaggerated the performance of its much vaunted test, track, and trace system: most contacts were traced by local health teams, with only a minority by the national, privately contracted call centres. 3Some reasons for this are grimly outlined by one doctor who signed up to work in them. 4
MIF as a biomarker and therapeutic target for overcoming resistance to proteasome inhibitors in human myeloma
Authors: Qiang Wang, Dongyu Zhao, Miao Xian, Zhuo Wang, Enguang Bi, Pan Su, Jianfei Qian, Xingzhe Ma, Maojie Yang, Lintao Liu, Youli Zu, Sai Ravi Pingali, Kaifu Chen, Zhen Cai, Qing Yi
Journal: Blood (2020)
Biomarkers in Down syndrome can help us understand Alzheimer's disease
Authors: Elizabeth Head, Beau Ances
Journal: The Lancet (2020)

Down syndrome is associated with increased risk of developing early-onset Alzheimer's disease, primarily because of the overexpression of the APP gene on chromosome 21. People with Down syndrome, as a form of genetically determined Alzheimer's disease, represent one of the largest cohorts at risk of early-onset Alzheimer's disease because virtually all adults with Down syndrome will develop Alzheimer's disease by age 40 years. 1 Lott IT Head E Dementia in Down syndrome: unique insights for Alzheimer disease research. Nat Rev Neurol. 2019; 15: 135-147 Crossref PubMed Scopus (102) Google Scholar However, the age range for the onset of cognitive decline is wide (from <50 years to >70 years). 2 Zigman WB Devenny DA Krinsky-McHale SJ et al. Alzheimer's disease in adults with Down Syndrome. Int Rev Res Ment Retard. 2008; 36: 103-145 Crossref PubMed Scopus (60) Google Scholar The characterisation of the preclinical phases of Alzheimer's disease is crucial for early diagnosis in this susceptible group of people. Clinical and biomarker changes of Alzheimer's disease in adults with Down syndrome: a cross-sectional studyAlzheimer's disease in individuals with Down syndrome has a long preclinical phase in which biomarkers follow a predictable order of changes over more than two decades. The similarities with sporadic and autosomal dominant Alzheimer's disease and the prevalence of Down syndrome make this population a suitable target for Alzheimer's disease preventive treatments. Full-Text PDF Open Access
Tumor-targeted CD28 bispecific antibodies enhance the antitumor efficacy of PD-1 immunotherapy
Authors: Janelle C. Waite, Bei Wang, Lauric Haber, Aynur Hermann, Erica Ullman, Xuan Ye, Drew Dudgeon, Rabih Slim, Dharani K. Ajithdoss, Stephen J. Godin, Ilyssa Ramos, Qi Wu, Erin Oswald, Patrick Poon, Jacquelynn Golubov, Devon Grote, Jennifer Stella, Arpita Pawashe, Jennifer Finney, Evan Herlihy, Hassan Ahmed, Vishal Kamat, Amanda Dorvilliers, Elizabeth Navarro, Jenny Xiao, Julie Kim, Shao Ning Yang, Jacqueline Warsaw, Clarissa Lett, Lauren Canova, Teresa Schulenburg, Randi Foster, Pamela Krueger, Elena Garnova, Ashique Rafique, Robert Babb, Gang Chen, Nicole Stokes Oristian, Chia-Jen Siao, Christopher Daly, Cagan Gurer, Joel Martin, Lynn Macdonald, Douglas MacDonald, William Poueymirou, Eric Smith, Israel Lowy, Gavin Thurston, William Olson, John C. Lin, Matthew A. Sleeman, George D. Yancopoulos, Andrew J. Murphy, Dimitris Skokos
Journal: Science Translational Medicine (2020)

Antibodies cross-linking the CD28 costimulatory pathway and a target antigen on tumors potentiate the effects of checkpoint immunotherapy.
Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome
Authors: Elizabeth A. Middleton, Xue-Yan He, Frederik Denorme, Robert A. Campbell, David Ng, Steven P. Salvatore, Maria Mostyka, Amelia Baxter-Stoltzfus, Alain C. Borczuk, Massimo Loda, Mark J. Cody, Bhanu Kanth Manne, Irina Portier, Estelle S. Harris, Aaron C. Petrey, Ellen J. Beswick, Aleah F. Caulin, Anthony Iovino, Lisa M. Abegglen, Andrew S. Weyrich, Matthew T. Rondina, Mikala Egeblad, Joshua D. Schiffman, Christian Con Yost
Journal: Blood (2020)
Ten considerations for effectively managing the COVID-19 transition
Authors: Katrine Bach Habersaat, Cornelia Betsch, Margie Danchin, Cass R. Sunstein, Robert Böhm, Armin Falk, Noel T. Brewer, Saad B. Omer, Martha Scherzer, Sunita Sah, Edward F. Fischer, Andrea E. Scheel, Daisy Fancourt, Shinobu Kitayama, Eve Dubé, Julie Leask, Mohan Dutta, Noni E. MacDonald, Anna Temkina, Andreas Lieberoth, Mark Jackson, Stephan Lewandowsky, Holly Seale, Nils Fietje, Philipp Schmid, Michele Gelfand, Lars Korn, Sarah Eitze, Lisa Felgendreff, Philipp Sprengholz, Cristiana Salvi, Robb Butler
Journal: Nature Human Behaviour (2020)
Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypes
Authors: Ferran Nadeu, David Martin-Garcia, Guillem Clot, Ander Díaz-Navarro, Martí Duran-Ferrer, Alba Navarro, Roser Vilarrasa-Blasi, Marta Kulis, Romina Royo, Jesús Gutiérrez-Abril, Rafael Valdés-Mas, Cristina López, Vicente Chapaprieta, Montserrat Puiggros, Giancarlo Castellano, Dolors Costa, Marta Aymerich, Pedro Jares, Blanca Espinet, Ana Muntañola, Inmaculada Ribera-Cortada, Reiner Siebert, Dolors Colomer, David Torrents, Eva Gine, Armando López-Guillermo, Ralf Küppers, Jose I. Martin-Subero, Xose S. Puente, Sílvia Beà, Elias Campo
Journal: Blood (2020)
Exercise and Well-being in Adult Survivors of Childhood Cancer—Time for Interventions
Authors: Jennifer W. Mack
Journal: JAMA Oncology (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Re: Ming-Chun Chan, Sharon E.K. Yeo, Yew-Lam Chong, Yee-Mun Lee. Stepping Forward: Urologists’ Efforts During the COVID-19 Outbreak in Singapore. Eur Urol 2020;78:e38–9
Authors: Guglielmo Mantica, Nazareno Suardi, Carlo Terrone
Journal: European Urology (2020)
Monoclonal immunoglobulins promote bone loss in multiple myeloma
Authors: Marita Westhrin, Vlado Kovcic, Zejian Zhang, Siv H. Moen, Tonje Marie Vikene Nedal, Albert Bondt, Stephanie Holst, Kristine Misund, Glenn Buene, Anders Sundan, Anders Waage, Tobias S. Slørdahl, Manfred Wuhrer, Therese Standal
Journal: Blood (2020)
Effects and moderators of coping skills training on symptoms of depression and anxiety in patients with cancer: Aggregate data and individual patient data meta-analyses
Authors: L.M. Buffart, M.A.C. Schreurs, H.J.G. Abrahams, J. Kalter, N.K. Aaronson, P.B. Jacobsen, R.U. Newton, K.S. Courneya, J. Armes, C. Arving, A.M. Braamse, Y. Brandberg, J. Dekker, R.J. Ferguson, M.F. Gielissen, B. Glimelius, M.M. Goedendorp, K.D. Graves, S.P. Heiney, R. Horne, M.S. Hunter, B. Johansson, L.L. Northouse, H.S. Oldenburg, J.B. Prins, J. Savard, M. van Beurden, S.W. van den Berg, J. Brug, H. Knoop, I.M. Verdonck-de Leeuw
Journal: Clinical Psychology Review (2020)
Epidemic and pandemic viral infections: impact on tuberculosis and the lung
Authors: Catherine Wei Min Ong, Giovanni Battista Migliori, Mario Raviglione, Gavin MacGregor-Skinner, Giovanni Sotgiu, Jan-Willem Alffenaar, Simon Tiberi, Cornelia Adlhoch, Tonino Alonzi, Sophia Archuleta, Sergio Brusin, Emmanuelle Cambau, Maria Rosaria Capobianchi, Concetta Castilletti, Rosella Centis, Daniela M. Cirillo, Lia D'Ambrosio, Giovanni Delogu, Susanna M.R. Esposito, Jose Figueroa, Jon S. Friedland, Benjamin Choon Heng Ho, Giuseppe Ippolito, Mateja Jankovic, Hannah Yejin Kim, Senia Rosales Klintz, Csaba Ködmön, Eleonora Lalle, Yee Sin Leo, Chi-Chiu Leung, Anne-Grete Märtson, Mario Giovanni Melazzini, Saeid Najafi Fard, Pasi Penttinen, Linda Petrone, Elisa Petruccioli, Emanuele Pontali, Laura Saderi, Miguel Santin, Antonio Spanevello, Reinout van Crevel, Marieke J. van der Werf, Dina Visca, Miguel Viveiros, Jean-Pierre Zellweger, Alimuddin Zumla, Delia Goletti
Journal: European Respiratory Journal (2020)

Major epidemics, including some that qualify as pandemics, such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), HIV, influenza A (H1N1)pdm/09 and most recently COVID-19, affect the lung. Tuberculosis (TB) remains the top infectious disease killer, but apart from syndemic TB/HIV little is known regarding the interaction of viral epidemics and pandemics with TB. The aim of this consensus-based document is to describe the effects of viral infections resulting in epidemics and pandemics that affect the lung (MERS, SARS, HIV, influenza A (H1N1)pdm/09 and COVID-19) and their interactions with TB. A search of the scientific literature was performed. A writing committee of international experts including the European Centre for Disease Prevention and Control Public Health Emergency (ECDC PHE) team, the World Association for Infectious Diseases and Immunological Disorders (WAidid), the Global Tuberculosis Network (GTN), and members of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Mycobacterial Infections (ESGMYC) was established. Consensus was achieved after multiple rounds of revisions between the writing committee and a larger expert group. A Delphi process involving the core group of authors (excluding the ECDC PHE team) identified the areas requiring review/consensus, followed by a second round to refine the definitive consensus elements. The epidemiology and immunology of these viral infections and their interactions with TB are discussed with implications for diagnosis, treatment and prevention of airborne infections (infection control, viral containment and workplace safety). This consensus document represents a rapid and comprehensive summary on what is known on the topic.
Diagnosing choledocholithiasis: better to be European or American?
Authors: Marc Barthet
Journal: Endoscopy (2020)

The paper from Jagtap et al. in this issue of Endoscopy compares the respective value of European Society of Gastrointestinal Endoscopy (ESGE) and American Society for Gastrointestinal Endoscopy (ASGE) criteria for predicting choledocholithiasis [1]. Both ESGE and ASGE recommendations for the management of common bile duct (CBD) stones were published in 2019 [2] [3]. Despite the publication of these guidelines and randomized controlled trials, many issues are still a matter of debate, not only for therapeutic management but also for CBD stone diagnosis and predicting the presence of choledocholithiasis [2] [3]. If clinicians could obtain a reliable and efficient preoperative diagnosis of choledocholithiasis, they could avoid, in many cases, the debate between endoscopic, surgical or combined approaches to manage these patients.
<i>Notes from the Field</i>: E-cigarette, or Vaping, Product Use–Associated Lung Injury Cases During the COVID-19 Response — California, 2020
Authors: Christina Armatas, Amy Heinzerling, Jason A. Wilken
Journal: MMWR Morbidity and Mortality Weekly Report (2020)

This report describes eight patients hospitalized with e-cigarette, or vaping, product use–associated lung injury and reported to the California Department of Public Health in April 2020 during the early coronavirus disease 2019 pandemic.
Bivalent therapeutic vaccine against HPV16/18 genotypes consisting of a fusion protein between the extra domain A from human fibronectin and HPV16/18 E7 viral antigens
Authors: Laura Arribillaga, Iciar Echeverria, Viriginia Belsue, Timothy Gomez, Teresa Lozano, Noelia Casares, Lorea Villanueva, Sonia Domingos-Pereira, Pedro J Romero, Denise Nardelli-Haefliger, Sandra Hervás-Stubbs, Pablo Sarobe, María Josefa Rodriguez, José L Carrascosa, Thomas Zürcher, Juan José Lasarte
Journal: Journal for ImmunoTherapy of Cancer (2020)

In vivo targeting of human papillomavirus (HPV) derived antigens to dendritic cells might constitute an efficient immunotherapeutic strategy against cervical cancer. In previous works, we have shown that the extra domain A from murine fibronectin (mEDA) can be used to target antigens to toll-like receptor 4 (TLR4) expressing dendritic cells and induce strong antigen-specific immune responses. In the present study, we have produced a bivalent therapeutic vaccine candidate consisting of the human EDA (hEDA) fused to E7 proteins from HPV16 and HPV18 (hEDA-HPVE7-16/18) and evaluate its potential as a therapeutic vaccine against cervical cancer. Recombinant fusion proteins containing HPV E7 proteins from HPV16 and HPV18 virus subtypes fused to hEDA were produced and tested in vitro on their capacity to bind TLR4 and induce the production of tumor necrosis factor-α or interleukin (IL)-12 by human monocytes and dendritic cells. The immunogenicity and potential therapeutic activity of the vaccine in combination with cisplatin or with the TLR3 agonist molecules polyinosinic-polycytidylic acid (Poly IC) or Poly ICLC was evaluated in mice bearing subcutaneous or genital orthotopic HPV16 TC-1 tumors. hEDA-HPVE7-16/18 prototype vaccine binds human TLR4 and stimulate TLR4-dependent signaling pathways and IL-12 production by human monocyte-derived dendritic cell. Vaccination with hEDA-HPVE7-16/18 induced strong HPVE7-specific Cytotoxic T lymphocyte (CTL) responses and eliminated established tumors in the TC-1-based tumor model. The antitumor efficacy was significantly improved by combining the fusion protein with cisplatin or with the TLR-3 ligand Poly IC and especially with the stabilized analog Poly ICLC. Moreover, hEDA-HPVE7-16/18+Poly ICLC induced full tumor regression in 100% of mice bearing orthotopic genital HPV tumors. Our results suggest that this therapeutic vaccine formulation may be an effective treatment for cervical tumors that do not respond to current therapies.
Molecular landscape and clonal architecture of adult myelodysplastic/myeloproliferative neoplasms
Authors: Laura Palomo, Manja Meggendorfer, Stephan Hutter, Sven Twardziok, Vera Ademà, Irene Fuhrmann, Francisco Fuster-Tormo, Blanca Xicoy, Lurdes Zamora, Pamela Acha, Cassandra M. Kerr, Wolfgang Kern, Jaroslaw P. Maciejewski, Francesc Solé, Claudia Haferlach, Torsten Haferlach
Journal: Blood (2020)
Plant Trait Networks: Improved Resolution of the Dimensionality of Adaptation
Authors: Nianpeng He, Ying Li, Congcong Liu, Li Xu, Mingxu Li, Jiahui Zhang, Jinsheng He, Zhiyao Tang, Xingguo Han, Qing Ye, Chunwang Xiao, Qiang Yu, Shirong Liu, Wei Sun, Shuli Niu, Shenggong Li, Lawren Sack, Guirui Yu
Journal: Trends in Ecology & Evolution (2020)

Functional traits are frequently used to evaluate plant adaptation across environments. Yet, traits tend to have multiple functions and interactions, which cannot be accounted for in traditional correlation analyses. Plant trait networks (PTNs) clarify complex relationships among traits, enable the calculation of metrics for the topology of trait coordination and the importance of given traits in PTNs, and how they shift across communities. Recent studies of PTNs provide new insights into some important topics, including trait dimensionality, trait spectra (including the leaf economic spectrum), stoichiometric principles, and the variation of phenotypic integration along gradients of resource availability. PTNs provide improved resolution of the multiple dimensions of plant adaptation across scales and responses to shifting resources, disturbance regimes, and global change.