tbuckley/cabot-search huggingface dataset:
Abstract 018: Association of the Change in Physical Activity and Cardiovascular Disease Outcomes in the Look AHEAD Trial
Authors: John M Jakicic, Janet E Fulton, Wei Lang, Michael P Walkup
Journal: Circulation (2018)

Introduction: The Look AHEAD trial examined cardiovascular disease incidence in adults with type 2 diabetes randomly assigned to an intensive lifestyle intervention compared to those randomly assigned to diabetes support and education (control). In a substudy, physical activity was assessed using accelerometry, which provides an opportunity to examine whether the incidence of cardiovascular disease varied by the measured change in physical activity. Hypothesis: There is a beneficial association between the 1- and 4-year change in physical activity and the pre-specified primary and secondary outcomes in participants in the Look AHEAD trial. Methods: Adults (N=1,978; 59.1±6.8 kg; 102.8±19.0 kg) with type 2 diabetes at 8 study sites, who completed physical activity was assessment using accelerometry for 1 week at 0, 1, and 4 years. MET-minutes per week of moderate-to-vigorous physical activity (MVPA) performed in bouts of at least 10 minutes was identified from the accelerometry data. The 1- and 4-year change in MVPA was computed as the difference from baseline. The primary outcome was pre-defined as non-fatal myocardial infarction, stroke, hospitalized angina, and cardiovascular disease death. The first secondary outcome was pre-defined as non-fatal myocardial infarction, stroke, hospitalized angina, CABG/PTCA, hospitalized congestive heart failure, carotid endarterectomy, peripheral vascular disease, and total mortality. The relationships between 1- and 4-year change in physical activity and the primary and secondary outcomes were examined using Cox proportional hazards models with data collapses across the two treatment groups. Hazard ratios (HR) were adjusted for age, sex, history of cardiovascular disease, duration of diabetes, diabetes medication use, baseline weight, change in weight, and baseline physical activity. Results: MVPA [Median (25 th , 75 th percentile)] was 167.6 (0,545.5), 205.4 (0, 700.2), and 91.3 (0, 418.9) MET-minutes per week at 0, 1 and 4 years, respectively. Change in MVPA at 1-year was not significantly associated with the primary outcome [HR per 100 MET-minutes per week = 1.001 (95% CI: 0.985, 1.017)] or secondary outcome [HR per 100 MET-minutes per week = 0.989 (95% CI: 0.966, 1.013)] assessed across 8.8±2.4 years of follow-up. Change in MVPA at 4-years was significantly associated with a reduction in the primary [HR per 100 MET-minutes per week = 0.949 (95% CI: 0.912, 0.987)] and the secondary outcome [HR per 100 MET-minutes per week = 0.897 (95% CI: 0.843, 0.954)] assessed across 9.2±1.8 years of follow-up. Conclusions: Change in physical activity at 4-years is associated with a reduction in incidence of cardiovascular disease in adults with type 2 diabetes. These findings suggest improvements in physical activity may need to be sustained for a relatively long period (4 years) to elicit a beneficial effect on incidence of cardiovascular disease.
ROLE OF NON-INVASIVE LEFT VENTRICULAR PRESSURE-STRAIN LOOP TO PREDICT CARDIAC DEATH AND ARRHYTHMIC RISK IN PATIENT WITH ORGANIC HEART DISEASE AND REDUCED LEFT VENTRICULAR EJECTION FRACTION
Authors: Marco Previtero, Danila Azzolina, Chiara Palermo, Rosaria M. Tenaglia, Giuseppe Sammarco, Niccolò Ruozi, Patrizia Aruta, Sabino Iliceto, Denisa Muraru, Luigi Badano
Journal: Journal of the American College of Cardiology (2019)
Microglial Phagocytosis of Newborn Cells Is Induced by Endocannabinoids and Sculpts Sex Differences in Juvenile Rat Social Play
Authors: Jonathan W. VanRyzin, Ashley E. Marquardt, Kathryn J. Argue, Haley A. Vecchiarelli, Sydney E. Ashton, Sheryl E. Arambula, Matthew N. Hill, Margaret M. McCarthy
Journal: Neuron (2019)
IMPACT OF DECREASED INSULIN RESISTANCE BY EZETIMIBE ON POSTPRANDIAL LIPID PROFILES AND ENDOTHELIAL FUNCTIONS IN OBESE, NON-DIABETIC METABOLIC SYNDROME PATIENTS WITH CORONARY ARTERY DISEASE
Authors: Akihiro Nakamura, Kenjiro Sato, Masanori Kanazawa, Masateru Kondo, Hideaki Endo, Tohru Takahashi, Eiji Nozaki
Journal: Journal of the American College of Cardiology (2019)
A MACHINE LEARNING ALGORITHM FOR DETERMINATION OF LEFT VENTRICLE VOLUMES AND FUNCTION: COMPARISON TO MANUAL QUANTIFICATION
Authors: Akhil Narang, Tamari Miller, Keith Ameyaw, Nimit Desai, Megan Sullivan, Elena Perez, Victor Mor-Avi, Roberto Lang, Amit Patel
Journal: Journal of the American College of Cardiology (2019)
CARDIORESPIRATORY FITNESS AND INCIDENT STROKE TYPES: THE FIT (HENRY FORD EXERCISE TESTING) PROJECT
Authors: Mahmoud Sobhi Al Rifai, Amjad Ahmed, Michael Blaha, Fatimah Almasoudi, Sherif Sakr, Waqas Qureshi, Clinton Brawner, Jonathan Ehrman, Steven Keteyian, Mouaz Al-Mallah
Journal: Journal of the American College of Cardiology (2019)
RESIDUAL INFLAMMATORY RISK IN PATIENTS WITH CHRONIC KIDNEY DISEASE UNDERGOING PERCUTANEOUS CORONARY INTERVENTION
Authors: Moritz Blum, Paul Guedeney, Bimmer Claessen, Melissa Aquino, Deborah Kalkman, Sabato Sorrentino, Rishi Chandiramani, Sherif Elsayed, Ridhima Goel, Birgit Vogel, Nitin Barman, Joseph Sweeny, Jason Kovacic, Annapoorna Kini, George Dangas, Usman Baber, Samin Sharma, Roxana Mehran
Journal: Journal of the American College of Cardiology (2019)
Abstract 506: Modulation of ZIC3 Expression in Pluripotent Stem Cells Using CRISPR-interference to Model Heterotaxy
Authors: Bohao Liu, Roberta Lock, Gordana Vunjak-Novakovic, Barry Fine
Journal: Circulation Research (2018)

Failure of proper left-right patterning during embryogenesis is an underlying mechanism of congenital heart disease (CHD). Heterotaxy (HTX) is a complex laterality syndrome in which multiple organs, including the heart, are abnormally arranged and mal-rotated. Loss-of-function mutations in ZIC3 , a zinc finger transcription factor within the GLI superfamily, have been associated with X-linked HTX. The mechanism behind how ZIC3 causes laterality defects remains unknown. To investigate this relationship, we developed a method to directly explore ZIC3 using induced pluripotent stem cells (iPSCs) at a molecular, cellular, and functional level through utilization of CRISPR interference (CRISPRi). A stable CRISPRi transgenic line was generated through lentiviral transduced vectors encoding inducible endonuclease-dead Cas9 and an sgRNA targeting the ZIC3 promoter. As ZIC3 is necessary for iPSC pluripotency, this inducible system allowed for a controllable knockdown while maintaining parent cell line pluripotency. RT-PCR confirmed that doxycycline induced a robust knockdown of ZIC3 expression over 72 hours with a fold change of 0.12 compared to non-induced. RNA-Seq was used to generate a gene expression profile of ZIC3 loss. This showed that 446 genes were significantly differentially expressed (adjusted p &lt; 0.01), and of those, 163 genes had an absolute fold change of greater than 1.5. Of the top 15 most significantly differentially expressed genes, 47% (7 of 15) are associated with the cytoskeleton, including gamma actin 1 and myosin light chain 9. These results were confirmed by RT-PCR. Confocal imaging revealed significant changes to the actin cytoskeleton in response to ZIC3 knockdown, with a notable reduction in filamentous actin. Current ongoing studies are focusing on the impact of ZIC3 knockdown on the structural and mechanical differences in differentiated cardiomyocytes. In summary, we have developed a method by which to explore CHD using iPSCs in order to better understand the genetic mechanisms of heterotaxy, and in future studies, other forms of CHD.
DON'T GO BREAKING MY HEART: ACUTE CELLULAR GRAFT REJECTION AFTER HEART TRANSPLANTATION COMPLICATED BY CARDIOGENIC SHOCK AND RESCUED WITH EXTRACORPOREAL MEMBRANE OXYGENATION
Authors: Isaac Tea, Arvind Bhimaraj, Aditi Singhvi, Bashar Hannawi, Imad Hussain, Ju Kim
Journal: Journal of the American College of Cardiology (2019)
ENDOTHELIN-1 LEVEL IN HEART FAILURE WITH PRESERVED EJECTION FRACTION WITH PULMONARY HYPERTENSION VERSUS PULMONARY ARTERIAL HYPERTENSION BOTH AT REST AND AT PEAK EXERCISE
Authors: Arif Albulushi, Apurva Patel, Douglas Stoller, Marshall Hyden, Adam Burdorf, Brian Lowes, Ronald Zolty
Journal: Journal of the American College of Cardiology (2019)
Efficacy and Safety of Newer Targeted Immunotherapy for Multiple Myeloma
Authors: Shehroz Aslam, Rida Riaz, Mustafa Nadeem Malik, Abdul Rafae, Warda Faridi, Saad Ullah Malik, Insija Ilyas Selene, Zunairah Shah, Chaudhry Saad Sohail, Faisal Mahfooz, Sharoon Samuel, Muhammad Yasir, Faiz Anwer
Journal: Blood (2018)
SUPERIOR SINUS VENOSUS DEFECT AND PERSISTENT LEFT-SIDED SUPERIOR VENA CAVA WITH RIGHT HEART ENLARGEMENT IN AN ASYMPTOMATIC MIDDLE-AGED WOMAN
Authors: Andy Lee, Aasim Afzal, Clay Barbin, Zachary Rosol, Ari Cedars, Haojie Wang, David Lofthus, Aldo Rafael, Charles Roberts, Peter McCullough
Journal: Journal of the American College of Cardiology (2019)
Use of Antibiotics for Dermatologic Procedures From 2008 to 2016
Authors: John S. Barbieri, Jeremy R. Etzkorn, David J. Margolis
Journal: JAMA Dermatology (2019)

<h3>Importance</h3> Although overall antibiotic use among dermatologists is decreasing, there has been an increase in use associated with dermatologic procedures during the past decade. This higher antibiotic use may increase antibiotic-associated adverse events and promote the development of antibiotic resistance. <h3>Objective</h3> To characterize antibiotic use associated with dermatologic procedures, including geographic variation. <h3>Design, Setting, and Participants</h3> Using Optum Clinformatics DataMart deidentified commercial claims data, we performed a repeated cross-sectional analysis of antibiotic prescribing by dermatologists from 2008 to 2016. Dermatology clinicians were identified by their National Uniform Claim Committee taxonomy codes, encounters for surgical procedures were identified by Common Procedure Terminology codes, and courses of oral antibiotics prescribed by these clinicians were identified by their National Drug Codes. <h3>Exposures</h3> Claims for oral antibiotic prescriptions associated with encounters with dermatologists associated with dermatologic procedures. <h3>Main Outcomes and Measures</h3> Frequency of antibiotic prescribing and associated procedures. Poisson regression models were used to assess for changes in the frequency of antibiotic prescribing over time. <h3>Results</h3> Between 2008 and 2016, among 1 934 633 encounters (1 128 244 unique patients, 854 072 [44.1%] were women and the median [interquartile range] age was 66 [52-76] years) for dermatologic procedures, oral antibiotic prescribing associated with benign excisions increased from 2.9% to 4.4% of visits (52.5% relative change; incidence rate ratio [IRR], 1.04; 95% CI, 1.03-1.04), antibiotic prescribing associated with malignant excisions increased from 4.2% to 6.3% of visits (49.5% relative change; IRR, 1.06; 95% CI, 1.05-1.06), and antibiotic prescribing associated with Mohs surgery increased from 9.9% to 13.8% of visits (39.7% relative change; IRR, 1.04; 95% CI, 1.03-1.04). There was greater than 2-fold variation in antibiotic prescribing rates across geographic census divisions. If higher prescribing divisions were to develop antibiotic prescribing rates similar to lower prescribing divisions, antibiotic use could be decreased by over 50%. <h3>Conclusions and Relevance</h3> Oral antibiotic prescribing by dermatologists associated with benign excisions, malignant excisions, and Mohs surgery is increasing over the past decade and there is substantial geographic variation. These findings highlight that there may be opportunities to optimize antibiotic use associated with dermatologic procedures.
REGADENOSON FOR PHARMACOLOGICAL STRESS TESTS - BLOOD PRESSURE, HEART RATE, AND MAJOR SIDE EFFECTS IN 5780 PATIENTS REFERRED FOR MYOCARDIAL SCINTIGRAPHY: A HIGH-VOLUME SINGLE-CENTER EXPERIENCE
Authors: Sigmund Silber, Manuela Rippel, Miriam Keller
Journal: Journal of the American College of Cardiology (2019)
Abstract 468: Mitochondrial Dysfunction and Senescence of Human Cardiac Progenitor Cells Are Prevented by Hypoxic Culture
Authors: Dieter A Kubli, Kelli I Korski, Mark A Sussman
Journal: Circulation Research (2018)

Rationale: Therapeutic potential of c-Kit + cardiac progenitor cells (CPCs) is modest in autologous cell therapy clinical trials and could benefit from optimization to maximize functional activity. Early proliferation arrest limits expansion potential of human CPCs in vitro . In contrast, self-renewal is preserved and mitochondrial reactive oxidative species (mtROS) minimized within the CPC hypoxic niche in vivo . Expansion under oxygen tension comparable to the hypoxic niche may therefore improve CPC reparative function. Hypothesis: Senescence of CPCs derived from heart failure patients is suppressed by dampening mtROS through long-term hypoxic culture. Methods and Results: Environmental oxygen was maintained with constant hypoxia (1% O 2 ; H-CPCs) or atmospheric oxygen tension (20 - 21% O 2 ; N-CPCs) for isolation and expansion of CPCs from patients undergoing left ventricular assist device implantation. A 4-fold increase in clonogenesis and 73% fewer senescence-associated β-Gal-positive cells were found in H-CPCs. Oxidative stress and DNA damage were also reduced with 80% lower malondialdehyde content and significantly fewer nuclear γ-H2AX foci in H-CPCs. Accumulation of dysfunctional mitochondria was revealed in N-CPCs through functional metabolic analyses. Basal (-59%), maximal (-50%), and ATP production-coupled (-62%) oxygen consumption rates were significantly lower in N-CPCs, despite upregulation of electron transport chain subunits and 72% greater mitochondrial DNA content than H-CPCs. MtROS was elevated, and large mitochondria with swollen morphology were found by TEM in N-CPCs, confirming mitochondrial damage. Key indicators of mitochondrial function including NAD + /NADH ratio and autophagic flux were preserved in H-CPCs. Conclusions: Development of mitochondrial dysfunction and senescence are consequences of normoxic CPC expansion. CPC senescence is delayed by preserving mitochondrial health and limiting oxidative damage through hypoxic culture.
THE CORRELATIONS BETWEEN ANTI-FACTOR XA ACTIVITY VALUES AND PROTHROMBIN TIME/ACTIVATED PARTIAL THROMBOPLASTIN TIME AT PEAK AND TROUGH TIMES IN PATIENTS ON DIRECT ORAL ANTICOAGULANTS THERAPY
Authors: Ryohei Ono, Kenichi Fukushima, Daichi Yamashita, Hidehisa Takahashi
Journal: Journal of the American College of Cardiology (2019)
THE IMPACT OF TEMPORARY INTERRUPTIONS OF WARFARIN ON DOWNSTREAM TIME IN THERAPEUTIC RANGE IN PATIENTS WITH ATRIAL FIBRILLATION: RESULTS FROM ORBIT AF
Authors: Malini Madhavan, DaJuanicia N. Holmes, Jonathan Piccini, James Freeman, Gregg Fonarow, Elaine Hylek, Peter Kowey, Kenneth Mahaffey, Karen Pieper, Eric Peterson, Paul Chan, Larry Allen, Daniel Singer, Gerald Naccarelli, James A. Reiffel, Benjamin Steinberg, Bernard Gersh
Journal: Journal of the American College of Cardiology (2019)
MEASURES OF WAIST AND HIP MODIFY SEX-SPECIFIC ASSOCIATIONS BETWEEN BODY MASS INDEX AND PREVALENCE OF CORONARY ARTERY CALCIFICATION IN OPPOSITE DIRECTIONS
Authors: Stefan Söderberg, Håkan Ahlström, Anders Blomberg, John Brandberg, Kenneth Caidahl, Kerstin Cederlund, Gunnar Engström, Jan Engvall, Erika Fagman, Karl Franklin, Tomas Hansen, Bo Hedblad, Ola Hjelmgren, Tomas Jernberg, Lars Lind, Hanna Markstad, Lars T. Nilsson, Anders Persson, Margaretha Persson, Annika Rosengren, Magnus Sköld, Johan Sundstrom, Eva Swahn, Ulf Strömberg, Carl Johan Östgren
Journal: Journal of the American College of Cardiology (2019)
Cloning and expression of the human galanin receptor 1 in head and neck cancer cells
Authors: Takeharu Kanazawa, Kiyoshi Misawa, Yuki Misawa, Pavan K. Kommareddi, Jairo A. Matthews, Andrew B. Cole, Tetsuya Tono, Nisha J. D’silva, Thomas E. Carey
Journal: Cancer Research (2004)

1864  We previously reported that loss of chromosome 18q develops with tumor progression and is associated with significantly decreased survival in head and neck cancer patients. Loss of heterozygosity (LOH) on 18q occurs in 50-75% of head and neck squamous cell carcinomas (HNSCC). The most common region of loss affecting 75% of HNSCC cell lines is centered on the microsatellite marker D18S70 in band 18q23. These results indicate the possible locus of a tumor suppressor gene in this area. One gene located within the common region of loss is galanin receptor type 1 (GALR 1). GALRs are members of G-protein coupled receptors, and there are three galanin receptors. GALR1 and GALR3 are reported to signal via the Gi/G0 pathway whereas GALR2 signals via G12/13. Previous studies have shown that galanin and its receptors mediate diverse physiological activities such as release of gastrin and stomach acid, and neurotransmitter and hormone release in the peripheral and central nervous system. However, the function and signaling of GALRs, especially GALR1 in HNSCC, is not fully understood. We postulated that GALR1 might function as a tumor suppressor gene by regulating cell growth. In this study, we established stable clones expressing GALR1 to assess the function of GALR1. The full length GALR1 gene was isolated from a human brain cDNA library by polymerase chain reaction (PCR) under optimized conditions. The resulting PCR product was cloned into the TA cloning vector that contains the cytomegalovirus (CMV) promoter (pCMV-GALR1). The vectors were sequenced by the University of Michigan DNA sequencing Core. The human laryngeal carcinoma cell line HEp-2 that does not express GALR1 was transduced with pCMV-GALR1, and stable clones were selected in G418. The expression of GALR1 was determined by western blotting. Compared with parent cells and empty vector controls, the growth rate of the GALR1 expressing clones was inhibited. The inhibition of proliferation was proportional to the GALR1 expression level. Furthermore, there was an obvious change in the morphology of stable clones. Inhibition of proliferation and altered morphology of the stable clones are consistent with GALR1 functioning as a possible tumor suppressor gene. These results suggest that the GALR1 signaling pathway regulates cell replication and epithelial morphology. Loss of this function may allow unregulated cell proliferation and migration. This research is supported in part by the NIH NIDCR (5 R01 DE12477), by the NIH through the University of Michigan’s Head and Neck SPORE grant (1 P50 CA97248), by the NIH NCI through the University of Michigan’s Cancer Center Support grant (5 P30 CA46592), and by the Research Center Core grant NIH NIDCD (P30 DC05188).
A Case for n-of-1 Trials
Authors: Sunita Vohra, Salima Punja
Journal: JAMA Internal Medicine (2019)

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ABLATION FOR MANAGEMENT OF VENTRICULAR TACHYCARDIA IN PATIENTS WITH SEVERE HEART FAILURE IS ASSOCIATED WITH LOWER INCIDENCE OF HEART FAILURE READMISSIONS COMPARED TO MEDICAL THERAPY ALONE
Authors: Natalie Beck, Peter Sauer, Alexis Tumolo, Amneet Sandhu, Matthew Zipse, Ryan Borne, Duy Nguyen, Joseph Schuller, Ryan Aleong, Christine Tompkins, Paul Varosy, Michael Rosenberg, Prateeti Khazanie, Natasha Altman, Andreas Brieke, William Cornwell, Eugene Wolfel, Amrut Ambardekar, Larry Allen, Wendy S. Tzou
Journal: Journal of the American College of Cardiology (2019)
SHARED GENETIC ARCHITECTURE OF BODY MASS INDEX AND PULMONARY ARTERY PRESSURE: AN ASSOCIATION ANALYSES OF A GENETIC RISK SCORE FOR BODY MASS INDEX AND INVASIVE HEMODYNAMICS
Authors: Timothy Thayer, Rebecca Levinson, Shi Huang, Tufik Assad, Eric Farber-Eger, Jonathan Mosley, Quinn Wells, Evan Brittain
Journal: Journal of the American College of Cardiology (2019)
PROGNOSTIC RELEVANCE OF PLASMA D-DIMER AND FIBRINOGEN LEVELS ON ADVERSE CARDIOVASCULAR EVENTS AFTER PERCUTANEOUS CORONARY INTERVENTION IN PATIENTS WITH CORONARY ARTERY DISEASE
Authors: Min Gyu Kang, Kyehwan Kim, Jae Seok Bae, Jeong Yoon Jang, Hyun Woong Park, Jin-Sin Koh, Jeong Rang Park, Yongwhi Park, Seok Jae Hwang, Kwak Choong Hwan, Jinyong Hwang, Young-Hoon Jeong
Journal: Journal of the American College of Cardiology (2019)
COMPUTED TOMOGRAPHY ANGIOGRAPHY CO-REGISTRATION WITH REAL-TIME FLUOROSCOPY IN CHRONIC TOTAL OCCLUSION PERCUTANEOUS CORONARY INTERVENTIONS
Authors: Iosif Xenogiannis, M. Nicholas Burke, Michael Megaly, Allison B. Hall, Peter Tajti, Pamela W. Morley, Bavana Rangan, Emmanouil S. Brilakis
Journal: Journal of the American College of Cardiology (2019)
Abstract 555: Exosomal MicroRNAs Contribute to Chronic Heart Failure Through Dysregulating Nuclear Factor Erythroid 2-Related Factor 2/Antioxidant Response Element Signaling
Authors: Changhai Tian, Lie Gao, Irving H Zucker
Journal: Circulation Research (2018)

The imbalance between the synthesis of free radicals and their elimination by antioxidant defense systems, results in macromolecular damage and disruption of cellular redox signaling, affecting cardiac structure and function, and thus contributing to the contractile dysfunction, myocardial hypertrophy and fibrosis. The Nrf2/Keap1/ARE signaling pathway is an important antioxidant defense mechanism and is closely associated with oxidative stress-mediated cardiac remodeling in CHF. Keap1, a redox-regulated substrate adaptor protein for the Cul3-dependent ubiquitin ligase complex generally mediates Nrf2 degradation. In this study, we hypothesized that circulating exosomal microRNAs may be involved in the translational repression of Nrf2 mRNA in the setting of CHF. We analyzed microRNA levels in exosomes from plasma of Sham and CHF rats. We found that three microRNAs including microRNA-27a, -28-3p and -34a which have potential binding sites in the 3’-UTR of Nrf2 mRNA, were highly enriched in exosomes derived from the circulation of CHF rats compared with sham rats (Fig.1). We labeled exosomes from CHF rats derived from plasma with PKH26 and administrated fluorescence-labeled exosomes into mice by various routes in order to track their distribution in vivo using the IVIS imaging system. Our preliminary data show that exosome distribution is dependent on the route of administration, and that circulating exosomes target the brain and heart. Taken together, these findings suggest that increased circulating exosomal microRNAs may contribute to Nrf2 dysregulation in CHF. These microRNAs may also serve as biomarkers for early diagnosis of CHF and therapeutic targets for CHF.
CHARACTERISTICS AND TREATMENT PATTERNS OF PATIENTS WITH SEVERE TRICUSPID REGURGITATION CONSIDERED FOR INTERVENTION
Authors: Brenden Ingraham, Sorin Pislaru, Vuyisile Tlhopane Nkomo, Rick A. Nishimura, John Stulak, Simon Maltais, Charanjit S. Rihal, Mackram Eleid
Journal: Journal of the American College of Cardiology (2019)
ATRIAL DEFIBRILLATION USING A NOVEL EPICARDIAL COOLING DEVICE: A COOL NEW SMALL TECHNOLOGY
Authors: Omar Ziad Yasin, Alan Sugrue, Greg Seifert, Steve Berhow, Rich Sanders, Joseph Duerr, Joanne Pedersen, Lisa Yngsdal, Dorothy Ladewig, Charles Ritrivi, Samuel Asirvatham, Paul Friedman
Journal: Journal of the American College of Cardiology (2019)