tbuckley/cabot-search huggingface dataset:
Abstract 206: Electrical Stimulation Enhances the Therapeutic Potential of Pediatric Cardiac Progenitor Cells
Authors: Joshua Maxwell, Carly Zaladonis, Daniel Jacobs, Michael Davis
Journal: Circulation Research (2018)

Nearly 1 in every 120 children born has a congenital heart defect, and many of these children go on to develop heart failure (HF). The emergence of cardiovascular regenerative medicine as a potential therapeutic strategy for pediatric HF has provided new avenues for treatment. Stem cells such as cardiac progenitor cells (CPCs) have shown promise in restoring cardiac function in adult pathologies; however, few studies have focused on the pediatric population. Recently, pediatric CPCs &gt;1year old have been shown to have reduced efficacy compared to younger cells. This indicates a need to enhance the regenerative potential of this population of cells for an autologous treatment for HF in pediatric patients. The regenerative potential of adult stem cells can be enhanced by ex vivo manipulation, and electrical stimulation (ES) is one such treatment we have examined in pediatric CPCs. We have previously shown that pediatric CPCs (1-5 years old) respond to ES by initiating intracellular Ca 2+ oscillations, and this induces phenotypic and genotypic changes in these cells. We then sought to examine the regenerative capacity of pediatric CPCs after conditioning with ES. In this study, we characterized the ES-induced changes in pediatric CPCs and showed they had a positive effect on the regenerative potential of these cells. ES-treated CPCs resulted in improved RV function following delivery compared with untreated CPCs in a juvenile rat model of right ventricular HF. Analysis of Ca 2+ handling in CPCs after chronic ES showed that these cells do not develop Ca 2+ transients or contractility similar to adult myocytes, and likely do not directly contribute to the contractility of the heart after injection. To determine if the effects were due to paracrine signaling, we tested the ability of conditioned media from these cells to regulate the function of failing cardiac myocytes. Isolated failing myocytes treated with conditioned media from CPCs showed improved Ca 2+ handling and contractility compared to untreated controls. Our data suggest that ES represents a novel treatment to enhance the therapeutic potential of pediatric CPCs, and the means of action of the modified cells is in part through a paracrine effect on resident cardiomyocytes.
Adherence to Tyrosine Kinase Inhibitor Affects Overall Survival in Adult Korean Chronic Myeloid Leukemia Patients; Based on the National Health Information Database
Authors: Jee Hyun Kong, Tae-Hwa Go, Jung Yeon Lee, Hye Bin Song, Hohyung Nam, Jieun Uhm, Shin Young Hyun
Journal: Blood (2018)
Abstract 223: Activation of CDK2 Mediates Doxorubicin-induced Cardiotoxicity
Authors: Peng Xia, Yuening Liu, David Liu, Zhaokang Cheng
Journal: Circulation Research (2018)

With the rapid increase of cancer survivors due to improved diagnosis and therapy in the past decades, cancer treatment-related cardiotoxicity is becoming an urgent concern for modern society. The anthracycline doxorubicin (DOX), one of the most effective chemotherapeutic agents to date, is known to cause cardiomyopathy through induction of cardiomyocyte apoptosis. We previously showed that the cyclin-dependent kinase (CDK) inhibitor p21 promotes resistance against DOX-induced apoptosis. In this study, we demonstrated that CDK2 activity and expression were significantly increased following DOX exposure in mouse heart and cultured neonatal rat cardiomyocytes (NRCMs). DOX-induced apoptosis, as measured by cleavage of caspase 3 and PARP, TUNEL staining, and MTT assay, was significantly suppressed by inhibition of CDK2 activity using small-molecule inhibitors, or CDK2-specific siRNA. Conversely, overexpression of CDK2 augmented DOX-induced apoptosis. DOX injection-induced CDK2 activation in mouse heart was correlated with upregulation of the BH3-only protein Bim. Mechanistically, CDK2 mediated DOX-induced expression of Bim, which was essential in triggering Bax/Bak-dependent mitochondrial outer membrane permeabilization. Pharmacological inhibition of CDK2 robustly repressed DOX-induced mitochondrial depolarization. These findings identify CDK2 as a key determinant of DOX-induced apoptosis in cardiomyocytes. Activation of CDK2 is necessary for DOX-induced Bim expression and mitochondrial damage. Also, pharmacological inhibition of CDK2 might be an effective cardioprotective strategy against anthracycline cardiotoxicity.
IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR THERAPY IN PATIENTS AGED OVER 75 YEARS WITH ISCHEMIC SYSTOLIC HEART FAILURE AS COMPARED WITH MEDICAL THERAPY
Authors: Marcelino Cortes, Juan Martinez Milla, Devesa Ana, Ana Lucia Rivero Monteagudo, Mikel Taibo Urquia, Marta Lopez-Castillo, Maria Martin-Mariscal, Sem Briongos-Figuero, Juan Antonio Franco Pelaez, José Tunon
Journal: Journal of the American College of Cardiology (2019)
PRIORITIES AND UNDERSTANDING OF PREGNANCY AMONG WOMEN WITH CONGENITAL HEART DISEASE: A MIXED-METHODS STUDY
Authors: Nicole L. Herrick, Jordan Stone, Neela Easwar, Yalda Dehghan, Howaida El-Said, Maria Moceri Casas, Laith Alshawabkeh
Journal: Journal of the American College of Cardiology (2019)
CXC MOTIF LIGAND 16: A NOVEL, INDEPENDENT PREDICTOR OF CARDIOVASCULAR DEATH AND MORBIDITY IN ACUTE CORONARY SYNDROMES - A SUBSTUDY OF THE PLATELET INHIBITION AND PATIENT OUTCOMES TRIAL
Authors: Thomas Andersen, Lars Wallentin, Axel Åkerblom, Thor Ueland, Pal Aukrust, Frederic Kontny
Journal: Journal of the American College of Cardiology (2019)
ASSOCIATION BETWEEN RENAL FUNCTION AND ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH RENAL FAILURE AS MEASURED BY CORONARY FLOW RESERVE ON RUBIDIUM-82 PET
Authors: Ahmed Hamad Aljizeeri, Mousa AlaliAlfaris, Dalia Ahmed, Jabir Farea, Awadelkarim Elneama, Ihab Suliman, Amjad Ahmed, Mohsen Alharthi, Ahmed Alsaileek, Mouaz Al-Mallah
Journal: Journal of the American College of Cardiology (2019)
ECHO OVERESTIMATES TRANS-AORTIC GRADIENTS IMMEDIATELY POST TAVR: A PRESSURE RECOVERY PHENOMENON IN A SIMULTANEOUS CATH AND ECHO STUDY
Authors: Ramy Mando, Amr E. Abbas, Michael Gallagher, Robert D. Safian, George S. Hanzel, Philippe Pibarot, Francis Shannon
Journal: Journal of the American College of Cardiology (2019)
CMR AND ECHOCARDIOGRAPHIC ASSESSMENT OF LEFT VENTRICULAR STRAIN IN TRANSTHYRETIN CARDIAC AMYLOIDOSIS
Authors: Kana Fujikura, Vasvi Singh, Sarah Cuddy, Paco Bravo, Mohamed Samir El-Sady, Ariana Nodoushani, Adil Menon, Marie F. Kijewski, Viviany R. Taqueti, Hicham Skali, Ron Blankstein, Marcelo Di Carli, Raymond Kwong, Rodney H. Falk, Sharmila Dorbala
Journal: Journal of the American College of Cardiology (2019)
Image Gallery: Multiple disseminated nodules with dysaesthesia in the Mexican–American border
Authors: J.A. García‐Lozano, C.D. Villarreal‐Villarreal, R. Franco‐Márquez, S.E. González‐González, J. Ocampo‐Candiani, O. Welsh
Journal: British Journal of Dermatology (2019)

Dear Editor, A 65-year-old woman who has always lived in Mexico, on the border with Texas, presented with a 5-year history of disseminated asymptomatic, skin-coloured nodules on her face, conjunctiva, oral mucosa, trunk, arms and legs (a, b).She had been treated elsewhere over the years with antibiotics without improvement.Physical examination with monofilament detected decreased sensitivity in both hands.A biopsy showed a chronic dermal granulomatous process and positive Fite stain (c, d).Polymerase chain reaction confirmed infection with Mycobacterium leprae. 1 World Health Organization leprosy multibacillary treatment was initiated 2 and the patient is currently on her 12th month of treatment, with marked improvement.
Abstract 21292: Total Laser Cycles - A Novel Measure of Transvenous Lead Extraction Difficulty
Authors: Ossama Elsaid, David O'Sullivan, Steven Zweibel, Edmond Cronin
Journal: Circulation (2017)

Background: Several variables have been identified as predictors for difficult or complicated transvenous lead extraction (TLE), including age and number of implanted leads, as well as patient’s age; however, a standard measure of TLE difficulty has not been described. Objective: Total laser cycles (TLC) delivered during laser-assisted TLE is an objective variable that could reflect the difficulty of TLE. This study investigated whether TLC is correlated with known predictors of difficult TLE. Methods: In a retrospective study of TLE procedures using the laser sheath, we analyzed TLC delivered and compared it to established predictors of procedural failure and complications. Results: Of 166 patients undergoing TLE, the laser sheath (SLS II or Glidelight, Spectranetics Inc,) was used as the primary extraction sheath in 130 patients, and 100 patients had complete TLC data available. The mean age of the oldest lead (AOL) was 7.1 ± 3.2 years, and 1.6 ± 0.7 leads (range, 1-4) were extracted per procedure. Two-thirds of procedures involved ICD leads. Clinical success was 97.5%, with one patient (0.6%) experiencing a major complication. Median TLC delivered was 1165 (IQR, 567-2062; range, 49 - 9522) Hz. TLC was positively correlated with AOL (ρ=0.203, p=0.042), and the combined age of leads extracted (ρ=0.287, p=0.004) Fig 1. TLC was also positively correlated with number of leads extracted per procedure (ρ=0.240, p=0.016). There was negative and non-significant correlation between TLC and patient’s age (ρ=-0.114, p=0.257). Conclusion: TLC showed significant correlation with known predictors of difficulty during TLE using the laser sheath. TLC can hence be used as an objective method to report the difficulty of TLE. Figures: Figure1: Panel A showing the correlation between age of oldest lead (AOL) and total laser cycles (TLC); Panel B showing the correlation between combined age of leads (CAL) and total laser cycles (TLC)
HIGHER LIPOPROTEIN (A) LEVEL IS ASSOCIATED WITH HIGHER PREVALENCE OF VULNERABLE PLAQUE PARTICULARLY IN PATIENTS WITH HIGHER LDL CHOLESTEROL LEVEL
Authors: Yusuke Muramatsu, Yoshiyasu Minami, Ayami Kato, Aritomo Katsura, Toshimitsu Sato, Ryota Kakizaki, Teruyoshi Nemoto, Takuya Hashimoto, Kazuhiro Fujiyoshi, Kentaro Meguro, Takao Shimohama, Taiki Tojo, Junya Ako
Journal: Journal of the American College of Cardiology (2019)
Abstract 399: Inhibition of NFE2L2-ARE Pathway by mtROS Contributes to Development of Cardiomyopathy and Left Ventricular Dysfunction in Chagas Disease
Authors: Jake J Wen, Nisha J Garg
Journal: Circulation Research (2018)

Aims: We investigated the effects of mitochondrial reactive oxygen species (mtROS) on nuclear factor (erythroid 2)-like 2 (NFE2L2) transcription factor activity during Trypanosoma cruzi (Tc) infection and determined whether enhancing the mtROS scavenging capacity preserved the heart function in Chagas disease. Results: C57BL/6 wild type (WT, female) mice infected with Tc exhibited myocardial loss of mitochondrial membrane potential, complex II (CII)-driven coupled respiration, and ninefold increase in mtROS production. In vitro and in vivo studies showed that Tc infection resulted in an ROS-dependent decline in the expression, nuclear translocation, antioxidant response element (ARE) binding, and activity of NFE2L2, and 35-99% decline in antioxidants’ (gamma-glutamyl cysteine synthase [γGCS], heme oxygenase-1 [HO1], glutamate-cysteine ligase modifier subunit [GCLM], thioredoxin (Trx), glutathione S transferase [GST], and NAD(P)H dehydrogenase, quinone 1 [NQO1]) expression. An increase in myocardial and mitochondrial oxidative adducts, myocardial interventricular septum thickness, and left ventricle (LV) mass, a decline in LV posterior wall thickness, and disproportionate synthesis of collagens (COLI/COLIII), αSMA, and SM22α were noted in WT.Tc mice. Overexpression of manganese superoxide dismutase (MnSOD) in cultured cells (HeLa or cardiomyocytes) and MnSODtg mice preserved the NFE2L2 transcriptional activity and antioxidant/oxidant balance, and cardiac oxidative and fibrotic pathology were significantly decreased in MnSODtg.Tc mice. Importantly, echocardiography finding of a decline in LV systolic (stroke volume, cardiac output, ejection fraction) and diastolic (early/late peak filling ratio, myocardial performance index) function in WT.Tc mice was abolished in MnSODtg.Tc mice. Innovation and Conclusion: The mtROS inhibition of NFE2L2/ARE pathway constitutes a key mechanism in signaling the fibrotic gene expression and evolution of chronic cardiomyopathy. Preserving the NFE2L2 activity arrested the mitochondrial and cardiac oxidative stress, cardiac fibrosis, and heart failure in Chagas disease.
State of the art review: from the seaside to the bedside: insights from comparative diving physiology into respiratory, sleep and critical care
Authors: Paul J Ponganis
Journal: Thorax (2019)

Anatomical and physiological adaptations of animals to extreme environments provide insight into basic physiological principles and potential therapies for human disease. In that regard, the diving physiology of marine mammals and seabirds is especially relevant to pulmonary and cardiovascular function, and to the pathology and potential treatment of patients with hypoxaemia and/or ischaemia. This review highlights past and recent progress in the field of comparative diving physiology with emphasis on its potential relevance to human medicine.
CARDIOVASCULAR BIOMARKERS AND HEART FAILURE RISK IN PATIENTS WITH STABLE ATHEROTHROMBOTIC DISEASE: A NESTED BIOMARKER STUDY FROM TRA 2°P-TIMI 50
Authors: David Berg, Benjamin Freedman, Marc Bonaca, Petr Jarolim, Benjamin M. Scirica, Erica Goodrich, Marc Sabatine, David Morrow
Journal: Journal of the American College of Cardiology (2019)
WORLDWIDE ORAL ANTICOAGULANT PRESCRIPTION PREVALENCE AND TRENDS IN PATIENTS WITH ATRIAL FIBRILLATION FROM A MULTI-NATIONAL COHORT: INSIGHTS FROM THE INTERNATIONAL COLLABORATIVE PARTNERSHIP FOR THE STUDY OF ATRIAL FIBRILLATION (INTERAF) COLLABORATIVE
Authors: Jonathan Chong Hsu, Masaharu Akao, Alvaro Avezum, Gerald Bloomfield, Shun Kohsaka, Deirdre Lane, Gregory Lip, Chang-Sheng Ma, Hisashi Ogawa, Angelo Ponirakis, Tatjana Potpara, Marwan Refaat, Tecla Temu, Wee Siong Teo, Hung-Fat Tse, Thomas Maddox
Journal: Journal of the American College of Cardiology (2019)
Abstract 420: RIP3 Interacts With Mitofilin in the Inner Membrane of Mitochondria to Induce Cardiomyocytes Necrosis After Ischemia/reperfusion
Authors: Yansheng Feng, Ngonidzashe B. Madungwe, Nathalie Tombo, Liu Li, Jean Chrisostome Bopassa
Journal: Circulation Research (2018)

Introduction: Receptor-Interacting Protein Kinase 3 (RIP3/RIPK3), a kinase promoting necroptotic cell death, has been shown to mediate adverse remodeling after myocardial infarction. We recently showed that knockdown of the inner membrane of mitochondria protein, mitofilin induces cell death by increasing mitochondria dysfunction via the AIF-PARP axis in rat H9c2 myoblasts. As we found that mitofilin interacts with the mitochondrial permeability transition pore (mPTP) regulator, cyclophilin D (CypD), we investigated whether RIP3 promotes cardiomyocyte death after I/R by increasing mitofilin loss, resulting in mitochondrial cristae structural damage and mPTP opening. Methods: C57BL/6J and RIP3 knockout mice hearts were subjected to 35 min ischemia followed by 180 min reperfusion. Myocardial infarct size was assessed by TTC staining. Mitochondrial function was assessed by mitochondrial ΔΨm, ROS production, and calcium retention capacity (CRC) required to induce mPTP opening. Mitochondrial integrity was measured by analyzing cristae morphology. RIP3 translocation was assessed by measuring the levels in the cytosol and mitochondrial fractions using Western blot and immunofluorescence labeling. The interaction between RIP3, CypD, and mitofilin was measured by co-immunoprecipitation. Results: We found that RIP3 KO mice developed less myocardial infarction as compared to WT and that RIP3 is translocated into mitochondria after I/R. In mitochondria, RIP3 interacts with mitofilin and CypD in the inner mitochondrial membrane (IMM). These interactions were associated with increased ROS production and decreased mitochondrial ΔΨm and CRC. In addition, we also found that RIP3 affects the expression of CypD and mitofilin. Conclusion: After I/R, RIP3 translocates into mitochondria to interact with CypD and mitofilin in the IMM resulting in increased mitochondrial ROS production and a decrease in ΔΨm, both of which promote the opening of the mPTP and destruction of mitochondrial cristae, leading to cardiomyocyte death. This finding points to the key role of RIP3 in cardiomyocyte death.
Clarifications Needed on Study of Association Between Physician Burnout and Patient Safety—Reply
Authors: Maria Panagioti, Alexander Hodkinson, Aneez Esmail
Journal: JAMA Internal Medicine (2019)

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EARLY DUAL ANTIPLATELET THERAPY DISCONTINUATION IN CANCER PATIENTS WITH NEWER GENERATION DRUG-ELUTING STENTS: A SINGLE CENTER EXPERIENCE
Authors: Cezar Iliescu, Dinu V. Balanescu, Juhee Song, Nicolas L. Palaskas, Kaveh Karimzad, Peter Kim, Lopez-Mattei Juan, Jean-Bernard Durand, Daniel Jipescu, Ezequiel D. Muñoz Gonzalez, William Ntim, Serban M. Balanescu, Konstantinos Marmagkiolis, Mehmet Cilingiroglu, Teodora Donisan
Journal: Journal of the American College of Cardiology (2019)
WHAT LURKS BENEATH: INCIDENTAL FINDING OF A PULMONARY ARTERY ANEURYSM SECONDARY TO PULMONARY VALVE STENOSIS
Authors: Jorge Juan Ballester Maldonado, Frantony Mercado Cabrera, Migdoel Cruz, Juan Nieves, Stephanie Torres-Ayala, Pedro Vargas Otero
Journal: Journal of the American College of Cardiology (2019)
microRNA and Severity of Sickle Cell Anemia
Authors: Thaís Priscila Biassi, Elvira Maria Guerra-Shinohara, Patrícia Natália Silva Moretti, Valeria de Freitas Dutra, Ana Carolina Cabañas-Pedro, Grazielle Mecabo, Gisele W. B. Colleoni, Maria Stella Figueiredo
Journal: Blood (2018)
HIGH-SENSITIVITY TROPONIN IS ASSOCIATED WITH HIGH-RISK CORONARY PLAQUE IN PSORIASIS
Authors: Jenis Argueta-Amaya, Amit Dey, Youssef Elnabawi, Clarence Ling, Sun Qian, Harry Choi, Noor Khalil, Milena Aksentijevich, Justin Rodante, Parag Shukla, Heather Teague, Andrew Keel, Leonard Genovese, Veit Sandfort, Marcus Chen, David Bluemke, Joel Gelfand, Alan Remaley, Martin Playford, Nehal Mehta
Journal: Journal of the American College of Cardiology (2019)
Abstract 575: Primary Cilia of Cardiac Neural Crest Cells Orchestrate Multiple Aspects of Cardiovascular Development
Authors: Lindsey A Fitzsimons, Adrian M Moran, Kerry L Tucker
Journal: Circulation Research (2018)

Cardiac neural crest cells (CNCC) are a specialized population of migratory neural crest cells that contribute to the developing cardiac outflow tract (OFT) and endocardial cushions (ECC). Like many eukaryotic cells, CNCC also possess primary cilia, which function as membrane-bound sensory organelles involved in intra- and extra-cellular communications in developing tissues. Previous work in our laboratory has shown that primary cilia of cardiac progenitor populations are critical orchestrators of both the septation and alignment of the developing OFT and interventricular septum. Our current in vivo models have refined the elimination of primary cilia to CNCC of the embryonic mouse heart using multiple neural crest-specific Cre drivers ( Wnt1 :Cre-Danielian et al,1998; Wnt1 :Cre2-Soriano et al, 2013) crossed with the Ift88 flox/flox mouse (Haycraft et al, 2007), resulting in elimination of primary cilia from CNCC during early embryonic heart development. Additionally, we have utilized a Td-Tomato (Tdt) reporter mouse line to track the migration of CNCC during various embryonic timepoints. Use of this reporter line revealed transient Tdt-positive CNCC contributions to the ventricular portion of the developing myocardium, in addition to the expected CNCC contributions to in the OFT and ECC regions. The resultant mutant phenotypes included a high incidence of outflow tract defects, impaired septation of the membranous interventricular septum, non-compaction of the developing ventricular myocardium, and perinatal lethality. Our data combine various immunohistochemical approaches to document, characterize, and quantify the novel presence of CNCC in the developing embryonic ventricular myocardium. These data suggest a potential modulatory role for primary cilia of CNCC in the development and maturation of the ventricular myocardium. Primary cilia-mediated signal transduction events that could account for the descried phenotypes are currently being elucidated.
ANTIARRHYTHMIC DRUGS OR CATHETER ABLATION IN THE MANAGEMENT OF IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR INTERVENTIONS: A NETWORK META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
Authors: Babikir Kheiri, Mahmoud Barbarawi, Yazan Zayed, Sahar Ahmed, Ghassan Bachuwa, Mustafa Hassan, Deepak L. Bhatt
Journal: Journal of the American College of Cardiology (2019)
SMALL-VESSEL PERCUTANEOUS CORONARY INTERVENTION WITH PLATINUM CHROMIUM EVEROLIMUS ELUTING STENTS: INSIGHTS FROM THE POOLED PLATINUM DIVERSITY AND PROMUS ELEMENT PLUS POST APPROVAL STUDIES
Authors: Paul Guedeney, Rishi Chandiramani, Bimmer Claessen, David Kandzari, Melissa Aquino, Scott Davis, Luis Tami, John Wang, Islam Othman, Osvaldo Gigliotti, Amir Haghighat, Sarabjeet Singh, Mario Lopez, Gregory Giugliano, Phillip Horwitz, Sabato Sorrentino, Paul Underwood, Dominic Allocco, Ian Meredith, Roxana Mehran, Wayne Batchelor
Journal: Journal of the American College of Cardiology (2019)
LONG-TERM OUTCOME COMPARISON OF DRUG-ELUTING STENTS AND BARE-METAL STENTS IN PATIENTS WITH HIGH BLEEDING RISK
Authors: Daisuke Sunohara, Ayumu Nagae, Takashi Miura, Keisuke Senda, Minami Taki, Masanori Kobayashi, Masafumi Kanai, Yukari Okuma, Takashi Yanagisawa, Naoto Hashizume, Kyuhachi Otagiri, Tatsuya Saigusa, Souichiro Ebisawa, Yusuke Miyashita, Hisanori Yui, Shusaku Maruyama, Chie Nakamura, Hiroaki Tabata, Daisuke Kashiwagi, Hideki Kobayashi, Takahiro Sakai, Tamon Kato, Ayako Okada, Hirohiko Motoki, Koichiro Kuwahara
Journal: Journal of the American College of Cardiology (2019)