tbuckley/cabot-search huggingface dataset:
PCT3, a Combination of Active Steroidal Saponins from the Paris Forrestii (Takht.) H. Li, Displays Potent Activity Against Acute Myeloid Leukemia By Suppressing the PBX1/RNF6/AKT/mTOR Signaling Pathway
Authors: Qin Lu, Yunjing Zheng, Yuehu Wang, Jian Pan, Xinliang Mao, Shaoyan Hu
Journal: Blood (2017)
Long-Term Follow up of Patients with HIV-Associated Non-Hodgkin Lymphoma (NHL) after Autologous Stem Cell Transplantation (ASCT)
Authors: Liana Nikolaenko, Saro Armenian, Joseph C. Alvarnas, John A. Zaia, Leanne Goldstein, Maria Viviana Marroquin, Amrita Y. Krishnan
Journal: Blood (2016)
Impact of Busulphan Exposure on Transplant Outcomes for Patients with Advanced Myelodysplastic Syndromes Undergoing CD34 Selected Allogeneic Hematopoietic Cell Transplantation
Authors: Roni Tamari, Proli Anthony, Juntig Zheng, Ann A. Jakubowski, Esperanza B Papadopoulos, Doris M Ponce, Sean Devlin, Craig S. Sauter, James W. Young, Sergio A. Giralt, H.R. Castro-Malaspina
Journal: Blood (2015)
Flt3 Internal Tandem Duplications Cooperate with Wnt Signaling in Leukemic Signal Transduction.
Authors: Lara Tickenbrock, Joachim Schwable, Markus Wiedehage, Bjoern Steffen, Chunaram Choudhary, Wolfgang E. Berdel, Carsten Muller-Tidow, Hubert Serve
Journal: Blood (2004)
No Harmful Impact of 90Yttrium-Ibritumomab Tiuxetan Combined with BEAM On Bone Marrow Microenvironment.
Authors: Otto Visser, Floortje Kessler, Lars Perk, Maria Vosjan, Guus van Dongen, Josée Zijlstra, Peter Huijgens, Sonja Zweegman
Journal: Blood (2009)
DNMT3A Mutations Enhance CpG Mutagenesis through Deregulation of the Active DNA Demethylation Pathway
Authors: Mathijs A. Sanders, Annelieke Zeilemaker, Adil al Hinai, Remco Hoogenboezem, François G. Kavelaars, Melissa Rijken, Eric M.J. Bindels, Bob Löwenberg, Peter J.M. Valk
Journal: Blood (2016)
A Systems Approach Identifies Essential FOXO3 Functions in Erythroblast Enucleation Process
Authors: Raymond Liang, Genís Campreciós, Yan Kou, Kathleen E McGrath, Roberta Novak, Seana C Catherman, Pauline Rimmele, Carolina L. Bigarella, Emery H Bresnick, Dmitri Papatsenko, Avi Ma'ayan, Velia M. Fowler, James Palis, Saghi Ghaffari
Journal: Blood (2014)
A Randomized Phase III Trial of Lenalidomide Plus High-Dose Dexamethasone Versus Lenalidomide Plus Low-Dose Dexamethasone in Newly Diagnosed Multiple Myeloma (E4A03): A Trial Coordinated by the Eastern Cooperative Oncology Group.
Authors: S. Vincent Rajkumar, Susanna Jacobus, Natalie Callander, Rafael Fonseca, David Vesole, Philip Greipp
Journal: Blood (2006)
The Combination Effect of Homoharringtonine and Ibrutinib on FLT3-ITD Mutant Acute Myeloid Leukemia
Authors: Xia Li, Xiufeng Yin, Huafeng Wang, Jiansong Huang, Mengxia Yu, Zhixin Ma, Chenying Li, Yile Zhou, Xiao Yan, Shujuan Huang, Jie Jin
Journal: Blood (2016)
Pro-Angiogenic Mir-296 Is Frequently Overexpressed and Is Associated with Advanced Stage Disease in Diffuse Large B-Cell Lymphoma
Authors: Natália Morais Borges, Marina Lourenço de Conti, Tathiana Azevedo de Andrade, Marina Petaccia Macedo, Maria Dirlei Ferreira de Souza Begnami, Antônio Corrêa Alves, Gisele Wally Braga Colleoni
Journal: Blood (2012)
Validation of a Non-Invasive Hemoglobin Estimation in Whole Blood Donors.
Authors: Murtadha K. Al-Khabori, Khalil Al Farsi, Mohammed Al-Huneini, Shahina Daar, Abdulhakeem Al-Hashim, Nasser Al-Kemyani, Arwa Z. Al-Riyami
Journal: Blood (2012)
Risk factors for disease progression in idiopathic pulmonary fibrosis
Authors: Ganesh Raghu, Brett Ley, Kevin K Brown, Vincent Cottin, Kevin F Gibson, Robert J Kaner, David J Lederer, Paul W Noble, Jin Woo Song, Athol U Wells, Timothy P Whelan, David A Lynch, Stephen M Humphries, Emmanuel Moreau, Krista Goodman, Scott D Patterson, Victoria Smith, Qi Gong, John S Sundy, Thomas G O"Riordan, Fernando J Martinez
Journal: Thorax (2019)

In this retrospective study of a randomised trial of simtuzumab in idiopathic pulmonary fibrosis (IPF), prodromal decline in forced vital capacity (FVC) was significantly associated with increased risk of mortality, respiratory and all-cause hospitalisations, and categorical disease progression. Predictive modelling of progression-free survival event risk was used to assess the effect of population enrichment for patients at risk of rapid progression of IPF; C-index values were 0.64 (death), 0.69 (disease progression), and 0.72 (adjudicated respiratory hospitalisation) and 0.76 (all-cause hospitalisation). Predictive modelling may be a useful tool for improving efficiency of clinical trials with categorical end points.
ATG Dose Correlates with Acute and Chronic GvHD In Patients Undergoing Reduced-Intensity Conditioning (RIC) Allogeneic Stem Cell Transplantation: A Large Retrospective Monocenter Analysis on 301 Patients.
Authors: Roberto Crocchiolo, Sabine Furst, Luca Castagna, Jean El Cheikh, Catherine Faucher, Raynier Deviller, Claire Oudin, Claire Oudin, Alberto Vazquez, Nawel Belmecheri, Angela Granata, Didier Blaise
Journal: Blood (2010)
The Activated K-RAS Protein Accelerates Human Derived-MLL/AF4 Induced Leukemo-Lymphomogenicity In Transgenic Mice Model
Authors: Hayato Tamai, Koichi Miyake, Miyuki Takatori, Noriko Miyake, Hiroki Yamaguchi, Kazuo Dan, Takashi Shimada, Koiti Inokuchi
Journal: Blood (2010)
Prognostic Factors of Severe Infections, and Effect of Primary Anti-Infectious Prophylaxis in MDS Patients Treated with Azacitidine (AZA). A Single Center Study On 144 Patients
Authors: Valérie Vidal, Marie Sebert, Sylvain Thepot, Thorsten Braun, Claude Gardin, Sabine Brechignac, Pierre Fenaux, Lionel Ades
Journal: Blood (2012)
Identification Of Diffuse Large b-Cell Lymphoma (DLBCL) Subtypes Defined By The Expression Of Stromal Proteins and Their Association With Proangiomirs and Antiangiomirs
Authors: Natalia Morais Borges, Marina Lourenço de Conti, Tathiana Azevedo de Andrade, Maria Dirlei Begnami, Antonio Correa Alves, Gisele Wally Braga Colleoni
Journal: Blood (2013)
Acquisition of Receptor Tyrosine Kinases, JAK2, or Ras Pathway Mutations Is Associated with Acute Myeloid Leukemia Transformation In Patients with Myelodysplastic Syndrome
Authors: Tung-Liang Lin, Ming-Chung Kuo, Der-Cherng Liang, Chein-Fuang Huang, Tung-Huei Lin, En-Hui Lee, Yu-Shu Shih, Jin-Hou Wu, Lee-Yung Shih
Journal: Blood (2010)
Serum Proteomic Profiling and Study of Haptoglobin Polymorphisms in Patients with Chronic GVHD after Allogeneic Hematopoietic Stem Cell Transplantation.
Authors: Joseph P. McGuirk, Ying Yan, Hao Gang, Weijian Hou, Sunil Abhyankar, Casey Williams, Robert Belt, Jianpa Ruan, Weisi Yan, Jeffery Wieman
Journal: Blood (2006)
Subgroup Analysis of Japanese Patients in a Phase I/III Study of Atezolizumab in ES-SCLC (IMpower133)
Authors: Yosuke Kawashima, Shunichi Sugawara, Shinji Atagi, Hiroaki Akamatsu, Hiroshi Sakai, Isamu Okamoto, Koichi Takayama, Hidetoshi Hayashi, Yuki Nakagawa, Tomohisa Kawakami, Makoto Nishio
Journal: Annals of Oncology (2019)
PWE-048 Performance of simple algorithm tests for the detection of fibrosis in non-alcoholic fatty liver disease: Abstract PWE-048
Authors: M Miller, H Jafferbhoy, S Walsh, J Dillon
Journal: Gut (2010)

<h3>Aim</h3> The aim of this study was to assess the performance of several simple algorithm tests for the detection of advanced fibrosis in NAFLD. <h3>Introduction</h3> NAFLD is an increasingly common clinical entity and represents a significant burden in both primary and specialist care settings. Histological evaluation remains the gold standard investigative tool, although there is an increasing need for non-invasive assessment and categorisation. Several simple algorithm tests, utilising both simple biochemical and anthropological measurements have been designed to detect severe forms of fatty liver. This is an attractive proposition especially in the triage of patients either by the Primary care physician or the hepatologist who are confident of the diagnoses of NAFLD in their patients but would like to stratify them further between simple steatosis and steatohepatitis with fibrosis. <h3>Methods</h3> We retrospectively applied seven scoring algorithms to 42 patients with biopsy proven NAFLD. All patients had negative liver screens and consumed &lt;21 units of alcohol per week for men and 14 units per week for women. All biopsies were reviewed by an experienced hepatopathologist and the NAS scoring system applied, as well as the associated fibrosis grade. <h3>Results</h3> Please see Abstract 048. Where the test correctly predicted the presence of non-advanced disease, we assigned that patient as a potentially avoidable biopsy. <h3>Conclusion</h3> Scoring systems employing routinely available clinical and biochemical markers are useful in the detection of advanced fibrosis in NAFLD. Simple scoring systems (AST/Plt, AST/ALT) perform as well as more complex algorithms (NAFLD-f). Application of simple scoring systems may reduce the number of biopsy performed.
A Blood Dendritic Cell Vaccine for Acute Myeloid Leukemia
Authors: Jennifer Hsu, Christian Bryant, Phillip Fromm, Michael Papadimitrious, Daniel Orellana, Hayley Suen, Shihong Yang, Claire Weatherburn, Robin Gasiorowski, Harry J Iland, Ross D Brown, Douglas E Joshua, Phoebe Joy Ho, John Gibson, Georgina Clark, Derek NJ Hart
Journal: Blood (2016)
Phase I Studies of Cellular Immunotherapy Using Central Memory Derived-CD19-Specific T Cells Following Autologous Stem Cell Transplantation for Patients with High-Risk Intermediate Grade B-Lineage Non-Hodgkin Lymphoma
Authors: Leslie Popplewell, Xiuli Wang, Araceli Naranjo, Suzette Blanchard, Jamie Wagner, ChingLam Wong, Ryan Urak, Wen-Chung Chang, Samer K Khaled, Tanya Siddiqi, Elizabeth E. Budde, Jingying Xu, Brenda Chang, Sandra H. Thomas, Stanley R. Riddell, Christine Brown, Michael C Jensen, Stephen J. Forman
Journal: Blood (2015)
Genomic Landscape and Prognosis in Pediatric Acute Myeloid Leukemia: A Study on the French ELAM02 Trial
Authors: Alice Marceau-Renaut, Nicolas Duployez, Christine Ragu, Arnaud Petit, Odile Fenneteau, Wendy Cuccuini, Martin Figeac, Myriam Labopin, Paola Fabiola Ballerini, Marie-Magdelaine Coudé, Stéphane Ducassou, Virginie Gandemer, Marlène Pasquet, Gérard Michel, Brigitte Nelken, Yves Bertrand, Andre Baruchel, Guy Leverger, Claude Preudhomme, Hélène Lapillonne
Journal: Blood (2016)
Clonal Expansions of Cytotoxic T Cells in the Blood of Patients with Waldenstrom's Macroglobulinaemia Are Anergic and Disappear After Nucleoside Analogue Therapy.
Authors: Ross D Brown, Jia Li, Daniel Sze, Mark Cowley, Warren Kaplan, Shihong Yang, Esther Aklilu, Karieshma Kabani, Phoebe Joy Ho, Yen S Loh, Tetsuo Yamagishi, Suilin Mo, Yuling Chen, Douglas Joshua
Journal: Blood (2009)
A 3′ UTR Single Nucleotide Polymorphism 829C→T in Dihydrofolate Reductase Gene Results in an Increase in DHFR Protein Level and MTX Resistance.
Authors: Prasunkumar J. Mishra, Giuseppe S.A. Longo, Lata G. Menon, Emine Abali, Debabrata Banerjee, Joseph Bertino
Journal: Blood (2004)
Cytomegalovirus Specific Immunity Protects From Cytomegalovirus Replication After Hematopoietic Stem Cell Transplantation.
Authors: Fátima de la Cruz Vicente, Omar BenMarzouk-Hidalgo, Irene Gracia-Ahufinger, Raul García-Lozano, Manuela Aguilar-Guisado, Jose Miguel Cisneros-Herreros, Alvaro Urbano-Ispizua, Ildefonso Espigado, Pilar Perez-Romero
Journal: Blood (2010)
The Therapeutic Response of Platelet Rich Plasma (PRP) for Androgenetic Alopecia Showed No Correlation with Growth Factors and Platelet Number
Authors: Bruno Lima Rodrigues, Silmara Aparecida De Lima Montalvão, Joyce Annichinno-Bizzacchi, Rebeca Cancela, Francesca Silva, Aline Paffaro, Stephany Cares Huber, José Luiz Rosenberis Cunha Junior, Erich Vinicius De Paula
Journal: Blood (2016)
CD5 Expression Is a Predictive Factor for Poor Prognosis among Biomarkers in Patients with Diffuse Large B-Cell Lymphoma Treated with Rituximab Plus CHOP Therapy.
Authors: Daisuke Ennishi, Masahiro Yokoyama, Kengo Takeuchi, Hiroaki Asai, Yuko Mishima, Yasuhito Terui, Shunji Takahashi, Mitsune Tanimoto, Kiyohiko Hatake
Journal: Blood (2007)
VAD-t (Vincristine, Adriamycin, Dexamethasone and Low-Dose Thalidomide) Is an Effective Initial Therapy with High Response Rates for Patients with Treatment Naïve Multiple Myeloma (MM).
Authors: Asher Alban Chanan-Khan, Kena C. Miller, Philip McCarthy, Alexandra Koryzna, Peter Kouides, Kathleen Donohue, Alice Mohr, Zale P. Bernstein, Arif Alam, Myron S. Czuczman
Journal: Blood (2004)
Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling By Suppression of Mir-146a in Acute Myeloid Leukemia
Authors: Sebastian Mohr, Carmen Doebele, Tobias Berg, Federico Comoglio, Julia Beck, Gabriela Alexe, Jasmin Corso, Hanibal Bohnenberger, Philipp Stroebel, Astrid Wachter, Tim Beissbarth, Frank Schnuetgen, Nadine Haetscher, Stefanie Goellner, Arefeh Rouhi, Lars Palmqvist, Michael A Rieger, Carsten Mueller-Tidow, Florian Kuchenbauer, Ekkehardt Schuetz, Henning Urlaub, Kimberly Stegmaier, R. Keith Humphries, Hubert Serve, Thomas Oellerich
Journal: Blood (2016)
In Vitro Deprivation of CD8+CD57+t Cells Promotes the Malignant Growth of Bone Marrow Stem/Progenitor Cells in Patients with Myelodysplastic Syndrome.
Authors: Qianqiao Zhang, Xiao Li, Zheng Zhang, Feng Xu, Qi He, Lingyun Wu, Chunkang Chang
Journal: Blood (2009)
Use of Blood Transfusions In Paroxysmal Nocturnal Hemoglobinuria Patients with and without Aplastic Anemia Enrolled In the Global PNH Registry
Authors: Hubert Schrezenmeier, Robert A Brodsky, Petra Muus, Monica Bessler, Jeffrey Szer, Jaroslaw P Maciejewski, Gérard Socié, Alvaro Urbano-Ispizua, Yuzuru Kanakura, Britta Hoechsmann, Wendell F Rosse, Gus Khursigara, Anders Karnell, Camille L Bedrosian, Peter Hillmen
Journal: Blood (2010)
Men Show Significantly Higher T Lymphocyte Mediated Immune Responses Against H-Y Than Multiparous Women: Results from a Cross-Sectional Analysis in 114 Volunteer Blood Donors and Implications for Immunotherapy
Authors: Mathias Lutz, Andrea Worschech, Miriam Alb, Sabine Gahn, Laura Bernhard, Michael Schwab, Stefanie Obermeier, Hermann Einsele, Ulrike Kämmerer, Peter Heuschmann, Erdwine Klinker, Christoph Otto, Stephan Mielke
Journal: Blood (2014)
Inhibition of HDAC8 Reactivates p53 and Abrogates Leukemia Stem Cell Activity in CBFβ-SMMHC Associated Acute Myeloid Leukemia
Authors: Jing Qi, Qi Cai, Sandeep Singh, Ling Li, Hongjun Liu, Tinisha McDonald, Allen Lin, Ravi Bhatia, wei-Jan Huang, chung-I Chang, ya-Huei Kuo
Journal: Blood (2014)
Conditional Survival Analysis of 816 Multiple Myeloma (MM) Patients Constitutes a Different Way to Provide More Specifically Determined Prognosis
Authors: Maximilian Schinke, Inga Promny, Stefanie Hieke, Johannes M. Waldschmidt, Gabriele Ihorst, Milena Pantic, Justus Duyster, Ralph Wäsch, Martin Schuhmacher, Monika Engelhardt
Journal: Blood (2015)
Translocation t(6;9)(p22;q34)/DEK-NUP214 rearranged Pediatric AML: A Retrospective International Study
Authors: Julie Damgaard Sandahl, Eva A. Coenen, Erik Forestier, Jochen Harbott, Bertil Johansson, Gitte Kerndrup, Souichi Adachi, Anne Auvrignon, H. Berna Beverloo, Lucy Chilton, Valerie de Haas, Christine J Harrison, Hiroto Inaba, Gertjan J.L. Kaspers, Der-Cherng Liang, Kuo-Sin Lin, Riccardo Masetti, Christine Perot, Andrea Pession, Susana C. Raimondi, Katarina Reinhardt, Daisuke Tomizawa, Nils von Neuhoff, Marco Zecca, Marry M. van den Heuvel-Eibrink, Henrik Hasle
Journal: Blood (2012)
Nutlin-3A, an MDM2 Antagonist, Induces p53-Dependent Cell Cycle Arrest and Apoptosis in Hodgkin Lymphoma (HL).
Authors: Elias Drakos, Athanasios Thomaides, Jiang Li, Marina Konopleva, L. Jeffrey Medeiros, Michael Andreeff, George Z. Rassidakis
Journal: Blood (2006)
Family Medicine
Authors: Naomi Baumslag
Journal: JAMA (1973)

<h3>To the Editor.—</h3> I heartily agree with Ransom and Vandervoort (225:1098, 1973) that family medicine should be taught to medical students as a core throughout their medical training in most disciplines. In a study of undergraduate family medicine programs, I found them mainly preceptorship in type, with few students involved for short periods only. In 32% of medical schools responding, less than 10% of the students were exposed to any "family medicine." Seventy percent of programs provided exposure for periods of under three months for one to two hours per week. In few programs was the whole family seen. Most did not require home visits (in only 8% were home visits required, and in 2% home visits were suggested). Most programs did not have a team approach. Specific criteria for family selection were not used, and only in 16% of programs were students following a specific family. Teaching family medicine
The Dual PI3K/mTOR Inhibitor PF-04691502 Induces Substantial Apoptosis in Chronic Lymphocytic Leukemia Cells in Vitro and Prolongs Survival in the Eµ-TCL1 Mouse Model
Authors: Matthew D Blunt, Matthew J Carter, Marta Larrayoz, Maria Montserrat Aguilar, Sarah Murphy, Mark Reynolds, Thomas Tipton, Kerry Cox, Jonathan C Strefford, Freda K Stevenson, Francesco Forconi, Graham Packham, Mark Cragg, Andrew J Steele
Journal: Blood (2014)
Association of Sickle Cell Trait with Risk of Coronary Heart Disease in African Americans
Authors: Hyacinth I Hyacinth, Carty L Cara, Samantha R Seals, Marguerite R. Irvin, Rakhi P. Naik, Melissa Caughey, Cheryl Winkler, Nora Franceschini, Gregory L Burke, Neil A Zakai, Jeffrey B Kopp, Suzanne E Judd, Robert J. Adams, Beatrice E. Gee, WT Longstreth, Leonard E Egede, Daniel T Lackland, Charles S. Greenberg, Taylor Herman, JoAnn E Manson, Nigel S. Key, Vimal K. Derebail, Abhijit V Kshirsagar, Aaron R Folsom, Suma H Konety, Virginia J Howard, Mattthew Allison, James G. Wilson, Adolfo Correa, Degui Zhi, Donna Arnett, George Howard, Mary Cushman, Alexander Reiner, Monika M Safford
Journal: Blood (2016)
The Trifunctional Antibody (tri-31C2) Targeting CD38 and CD3 Has a Stronger Anti-Myeloma Effect Than the Chimeric Anti-CD38 Monoclonal Antibody (ch-31C2)
Authors: Tadao Ishida, Hiroshi Yasui, Kazuya Ishiguro, Yuka Aoki, Hiroshi Ikeda
Journal: Blood (2016)
Prolonged Survival Following Imatinib Failure for CML Patients in CP May Require Multiple TKI Strategies for Responding Patients,
Authors: Dragana Milojkovic, Jane F Apperley, Amr R Ibrahim, Marco Bua, Alistair Reid, Gareth Gerrard, Letizia Foroni, Katy Rezvani, John M Goldman, David Marin
Journal: Blood (2011)
Identification of a Novel Chromosomal Translocation t(11;16)(q23;q22) Fusing MLL to Enhancer of mRNA Decapping (EDC)-4 in Smoldering Acute Myeloid Leukemia
Authors: Heiko Becker, Keisuke Kataoka, Gabriele Greve, Jesús Duque Afonso, Tobias Ma, Sabine Bleul, Milena Pantic, Julia Schüler, Justus Duyster, Michael L Cleary, Seishi Ogawa, Michael Lübbert
Journal: Blood (2016)
Trajectory and mortality of preserved ratio impaired spirometry: the Rotterdam Study
Authors: Sara Renata Alex Wijnant, Emmely De Roos, Maryam Kavousi, Bruno Hugo Stricker, Natalie Terzikhan, Lies Lahousse, Guy G. Brusselle
Journal: European Respiratory Journal (2019)

Preserved ratio impaired spirometry (PRISm) is a heterogeneous condition but its course and disease progression remain to be elucidated. We aimed to examine its prevalence, trajectories and prognosis in the general population. In the Rotterdam Study (population-based prospective cohort) we examined prevalence, trajectories and prognosis of subjects with normal spirometry (controls; forced expiratory volume in 1 s (FEV 1 )/forced vital capacity (FVC) ≥0.7, FEV 1 ≥80%), PRISm (FEV 1 /FVC ≥0.7, FEV 1 &lt;80%) and chronic obstructive pulmonary disease (COPD) (FEV 1 /FVC &lt;0.7) at two study visits. Hazard ratios with 95% confidence intervals for mortality (until December 30, 2018) were adjusted for age, sex, body mass index, current smoking and pack-years. Of 5487 subjects (age 69.1±8.9 years; 7.1% PRISm), 1603 were re-examined after 4.5 years. Of the re-examined PRISm subjects, 15.7% transitioned to normal spirometry and 49.4% to COPD. Median lung function decline was highest in subjects with incident PRISm (FEV 1 −92.8 mL·year −1 , interquartile range (IQR) −131.9– −65.8 mL·year −1 ; FVC −93.3 mL·year −1 , IQR −159.8– −49.1 mL·year −1 ), but similar in persistent PRISm (FEV 1 −30.2 mL·year −1 , IQR −67.9– −7.5 mL·year −1 ; FVC −20.1 mL·year −1 , IQR −47.7–21.7 mL·year −1 ) and persistent controls (FEV 1 −39.6 mL·year −1 , IQR −64.3–−12.7 mL·year −1 ; FVC −20.0 mL·year −1 , IQR −55.4–18.8 mL·year −1 ). Of 5459 subjects with informed consent for follow-up, 692 (12.7%) died during 9.3 years (maximum) follow-up: 10.3% of controls, 18.7% of PRISm subjects and 20.8% of COPD subjects. Relative to controls, subjects with PRISm and COPD Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2–4 had increased all-cause mortality (PRISm: HR 1.6, 95% CI 1.2–2.0; COPD GOLD 2–4: HR 1.7, 95% CI 1.4–2.1) and cardiovascular mortality (PRISm: HR 2.8, 95% CI 1.5–5.1; COPD 2–4: HR 2.1, 95% CI 1.2–3.6). Mortality within &lt;1 year was highest in PRISm, with patients often having cardiovascular comorbidities (heart failure or coronary heart disease; 70.0%). PRISm is associated with increased mortality and this population encompasses at least three distinct subsets: one that develops COPD during follow-up, a second with high cardiovascular burden and early mortality, and a third with persistent PRISm and normal age-related lung function decline.
High Predictivity of IL28B Genotype for Natural Clearance of HCV-RNA in Patients with Hemoglobinopathies
Authors: Maria Concetta Renda, Rosario Fabio Ruggeri, Angela Piazza, Disma Renda, Gaetano Restivo, Aurora Travia, Salvatore Madonia, Mario Cottone, Aurelio Maggio
Journal: Blood (2010)
First-Line Treatment with Fludarabine (F), Cyclophosphamide (C), and Rituximab (R) (FCR) Improves Overall Survival (OS) in Previously Untreated Patients (pts) with Advanced Chronic Lymphocytic Leukemia (CLL): Results of a Randomized Phase III Trial On Behalf of An International Group of Investigators and the German CLL Study Group.
Authors: Michael Hallek, Guenter Fingerle-Rowson, Anna-Maria Fink, Raymonde Busch, Jiri Mayer, Manfred Hensel, Georg Hopfinger, Georg Hess, Ulrich von Gruenhagen, Manuela A. Bergmann, John Catalano, Pier Luigi Zinzano, Federico Caligaris Cappio, John F Seymour, Alain Berrebi, Ulrich Jaeger, Bruno Cazin, Marek Trneny, Anne Westermann, Clemens-Martin Wendtner, Barbara F. Eichhorst, Peter Staib, Sebastian Boettcher, Matthias Ritgen, Myriam Mendila, Michael Kneba, Hartmut Doehner, Stephan Stilgenbauer, Kirsten Fischer
Journal: Blood (2009)
Erratum: Corrigendum: Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice
Authors: Calum C Bain, Alberto Bravo-Blas, Charlotte L Scott, Elisa Gomez Perdiguero, Frederic Geissmann, Sandrine Henri, Bernard Malissen, Lisa C Osborne, David Artis, Allan McI Mowat
Journal: Nature Immunology (2014)
FLT3 Inhibitor Therapy for Patients with Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML): Impact On Survival According to FLT3 Status.
Authors: Naveen Pemmaraju, Hagop M. Kantarjian, Farhad Ravandi, Guillermo Garcia-Manero, Borthakur Gautam, Sameer A Parikh, Marina Konopleva, Steven M. Kornblau, Michael Andreeff, Susan O'Brien, Jorge Cortes
Journal: Blood (2009)
Dual Inhibition of mTORC1/mTORC2 Induces Apoptosis of Mantle Cell Lymphoma by Preventing Rictor Mediated AKTS473 Phosphorylation by Potentiating AKT2-PHLPP1 Association
Authors: Mamta Gupta, Andrea Wahner Hendrickson, Jing Jing Han, Mary Stenson, Linda Wellik, Sharon Barr, Scott H. Kaufmann, Thomas E. Witzig
Journal: Blood (2010)
New Determination Method for Extensive Gene Deletions In Diamond–Blackfan Anemia
Authors: Madoka Kuramitsu, Tomohiro Morio, Masatoshi Takagi, Tsutomu Toki, Kiminori Terui, RuNan Wang, Atsuko Masumi, Takuo Mizukami, Haruka Momose, Kazuya Takizawa, Kazunari Yamaguchi, Etsuro Ito, Isao Hamaguchi
Journal: Blood (2010)
Bortezomib, Dexamethasone, Thalidomide and Melphalan (VDT-Mel) Preparative Regimen in Autologous Stem Cell Transplant (ASCT) Results in a Very High Stringent CR (sCR) Rate in Multiple Myeloma (MM)
Authors: Kalyan Nadiminti, Kamal Kant Singh Abbi, Annick Tricot, Allyson Schultz, Lindsay Dozeman, Sarah L Mott, Fenghuang Zhan, Guido J Tricot
Journal: Blood (2015)