tbuckley/cabot-search huggingface dataset:
Changes of thyroid function in depressive patients with attempted suicide
Authors: Min-feng Cheng, Sheng-lin Wen, Hou-liang Wang
Journal: BMJ (2010)

Thyroid function [triiodothyronine(T3), thyroxine(T4), free T3(FT3), free T4(FT4),and thyroid stimulating hormone (TSH) ] were tested by radioimmunoassay in 56 depressive patients with attempted suicide, 85 patients without suicide attempt and 40 healthy subjects (controls).The serum levels of T3 and FT3 in the patients with attempted suicide were lower than those in the patients without suicide attempt and the controls ( F = 4.937 and 5.01 1, both P ＜ 0.05 ).The lower serum levels of T3 and FT3might be the risk factor of suicide in depressive patients.

Key words: 
Depressive disorder;  Thyroid hormones
Health-related values of newly-diagnosed cancer patients: Qualitative analysis of oncology nurse-led discussions.
Authors: Paul Shin, Molly Okpako, Kathleen Lynch, Danielle R. Romano, Camila Bernal, Anjali V. Desai, Andrew S. Epstein
Journal: Journal of Clinical Oncology (2020)

e24163 Background: A novel, patient-verified summary documenting nurse-led discussions assessing health-related values of newly-diagnosed cancer patients has been implemented in outpatient gastrointestinal (GI) oncology clinics, but the content of these discussions has not previously been analyzed. Methods: Three interdisciplinary coders met and reviewed values summaries for 40 patients. Phase One meetings consisted of identifying key domains to guide line-by-line coding with ATLAS.ti software, codebook generation, and quality assurance of codebook fidelity. Phase Two meetings consisted of independent review and code categorization, followed by three successive consensus meetings of coders to identify themes. Results: Content analysis of 40 patient values summary documents revealed 5 distinct themes: Family, friends, and faith as sources of strength; strong family ties predominate definitions of living well. Despite this, patients stated that communication with loved ones about values and goals was limited; 35% of patients had not discussed core values prior to nurse-led discussion. Patients emphasized information processing and communication preferences as important definitions of selfhood. Patients defined treatment goals as survival and maintenance or return to “normal life” for as long as possible. When asked about treatment preferences during potential future crisis, patients emphasized quality of life over survival. Conclusions: Early, nurse-led values discussions provide important and unique data that are informative and actionable by clinicians in the delivery of person-centered care. Thematic analysis reveals that while family and friends are important, patients often had not discussed core values or care preferences with them. Although patients desire to live longer, treatment preferences during crisis are also shaped by expected quality of life from interventions. Assessment and creation of patient values summaries captures nuanced data that can facilitate discussion with loved ones and play a key role in surrogate decision-making during moments of crisis. Further mixed-methods analysis of patient variables ( e.g., age, stage) modifying values and impact on patient-reported outcomes is warranted.
An FDA analysis of the association of tumor growth rate and overall and progression-free survival in metastatic non-small cell lung cancer (NSCLC) patients.
Authors: Yutao Gong, Jeremy Mason, Yuan-Li Shen, Elaine Chang, Dickran Kazandjian, Gideon Michael Blumenthal, Harpreet Singh, Marc Robert Theoret, Shenghui Tang, Richard Pazdur, Julia A. Beaver
Journal: Journal of Clinical Oncology (2020)

9541 Background: Previous studies have suggested that tumor growth rate (g), estimated using prostate-specific antigen values, is associated with overall survival (OS) in prostate cancer (Wilkerson, 2016). We performed a retrospective pooled analysis in non-small cell lung cancer (NSCLC) to investigate the extent to which g values estimated using radiological tumor measurements in clinical trials are associated with survival. Methods: We identified 24 randomized clinical trials submitted to FDA between 2013 and 2019 investigating either immune checkpoint inhibitor (ICI) or targeted therapy (TT) in pts with metastatic NSCLC. Of 9934 patients (pts) enrolled, 5532 pts (2401, 1189, and 1942 pts treated with ICI, TT, and chemotherapy respectively) had sufficient data to derive a valid g. The g was evaluated by both type and line of therapy. Pts were then grouped according to quartiles of g, with Q1 being the lowest. We calculated OS and progression-free survival (PFS) for each group via the Kaplan-Meier method, and used the Cox model for group comparison. Results: Median g was 9.7E-4, 1.4E-3, and 2.2E-3/day, and median OS was 34.2, 21.3, and 15.3 months (mo), in pts treated with TT, ICI, and chemotherapy, respectively, regardless of lines of therapy. When treated with the same type of therapy, pts receiving 2 nd line therapy had a higher median g than those receiving 1 st line. The median survival and log-rank hazard ratios for pts treated with 1 st line ICI monotherapy are shown in the Table. Conclusions: TT is associated with the lowest median g, followed by ICI, and then chemotherapy, perhaps due to patient selection, better inherent biology/natural history, or favorable results of TT on selected tumors. Regardless, we found that g is inversely associated with survival, across treatment types. This relationship is also observed in pts treated with the same type and line of therapy (for example, 1 st line ICI), where Q1 has the longest survival, followed by Q2, Q3, and then Q4. In summary, our exploratory analysis suggests that g derived from radiological tumor measurements in NSCLC may relate to survival. Prospective studies are needed to evaluate if g might be an earlier endpoint compared to classical response criteria. [Table: see text]
联合用药与复方制剂在高血压治疗中的作用
Authors: 张叶萍, 顼志敏
Journal: BMJ (2010)

目前世界各个国家高血压的治疗现状仍不容乐观,高血压的知晓率、治疗率和达标率仍然很低,如何提高三率水平是我国高血压防治的主要任务.造成我国高血压达标率低的一个重要原因就是高血压用药配伍不合理,使患者未得到有效的治疗。
An agenda for improving basic health care in China
Authors: Alain J. Montegut, 顾湲
Journal: BMJ (2006)

世界各地的通(全)科医生服务具有多种传统.当然,它也在中国人民的医疗保健中发挥了重要作用. 随着全科医学专业的成长,其骨干医生能做什么或应该做些什么的问题呈现出来.在中国大陆,对全科医疗的范围没有一个清晰的定义,因此,大学和社区举办的培训项目都没有一套立足于能力培养的课程.实际上,甚至连同行们在提及该专业的名称时也会发生混乱,全科医疗、全科医学还是家庭医学?确定名称和确定这些医生的工作内容,对于这个学科的未来至关重要.在中国卫生部和教育部,对全科医生培训问题的讨论越来越多,于是2005年10月在北京举办了一次国际家庭医学会议.
Foreign body-induced gastrointestinal perforation or acute abdomen in gynaecological practice: case report and literature review
Authors: Hong-hui Shi, Lan Zhu, Awaguli, Ayeti Simayi
Journal: BMJ (2008)

Based on retrospective study of one case of foreign body-induced gastrointestinal perforation and systematic review of related literature, we found that foreign body induced-gastrointestinal perforation was characterized by low incidence and none specific clinical or imaging manifestations. Laparoscopy as a minimally invasive procedure could help to get definite diagnosis, while laparotomy seemed to be equally important in disease diagnosis and treatment.

Key words: 
Gastrointestinal perforation; Misdiagnosis
Immunological functional study by use of the chemotherapy drug plus immunologic hapten like penicillin on the fibrosis of local tumor inflammatory reaction and the immunity of tumor-bearing mice.
Authors: Bian Li, Dong Chen, Yan Han, Jian Zhang, Guoqin Zheng, Yanfei Wu, Qiang Fu, Baofa Yu
Journal: Journal of Clinical Oncology (2020)

e15196 Background: Observe the antitumor effect of intratumoral injection of chemotherapy drugs or combined with immune adjuvant on Balb/c and c57 tumor bearing mice and the local inflammatory response, fibrosis and immune effect of tumor. Methods: H22 ascites tumor was inoculated in the armpit of BABL / c mice left forelimb to establish subcutaneous solid tumor model of liver cancer, B16 melanoma tumor filtrate was inoculated in the armpit of C57 mice left forelimb to establish subcutaneous solid tumor model of melanoma. The mice were randomly divided into DNP control group, penicillin control group, I group, II group, III group, IV group, V group, VI group, DOX control group, PYM control group, BLM control group and control group when the longest tumor diameter was about 5-8mm. On the first day of the experiment, the mice in each group were injected with corresponding of different group drugs. Three mice in each group were killed on day 1, day 4 and day 7 respectively and then the tumors were taken The C57 mice were used for immunohistochemistry BABL/c mice to detect the content changes of various fibroproliferative, inflammatory and immune related factors. Results: I group: The expression of COL1A1, CD4, IL12A, TGFB1, elastin, NFkB, COX 2, CD11c, CD8 and TNFa in group I was higher than that in other factors at day 1. After 4 and 7 days of administration, all factors decreased significantly; The results of C57 Mouse immunohistochemistry showed that the expression of CD4, cd11bc, Foxp3 in tumor tissue of group V was significantly increased on the first day after administration, and the expression of CD4, CD8, CD86, CD11bc in tumor tissue of group V was significantly increased on the seventh day. Conclusions: The results of immunohistochemistry and PCR showed that the content of fibroproliferative, inflammatory and immune factors in tumor tissue changed significantly after administration og intratumoral injection of combination drugs and penicillin with H2O2. All the above results has showed that chemotherapy drug and hapten was released in the tumor through H2O2 and induced the inflammatory reaction inside tumor (including various fiber proliferation and tumor growth inhibition) as well as the systemic immune response, this also is called abscopal effect.
电击伤致呼吸心跳骤停抢救成功一例
Authors: 张志刚, 任静, 赵敏, 刘伟, 王林
Journal: BMJ (2011)

患者男,48岁.2009年6月15日触及380 V高压线后昏迷、呼吸心跳骤停,5 min后于当地医院行心肺复苏术、气管插管、呼吸机辅助呼吸,抢救5 min后心跳恢复,但仍处于昏迷状态,无自主呼吸,于18 h后转入我院急诊科.入院体检:深度昏迷,压眶无反应,体温37.8 ℃,心率98次/min,血压119/75 mm Hg(1 mm Hg=0.133 kPa),血氧饱和度(SpO2)98%,呼吸19次/min(呼吸机辅助呼吸),双侧瞳孔等大正圆,直径1.5 mn,光反射未引出,胸前可见电除颤后红色印迹,双肺呼吸音粗,未阐及干湿啰音,心音低钝,律齐,未闻及病理性杂音;腹软,肝脾肋下未触及;双下肢无浮肿,双侧Babinski征(+),右手背2处淤青,面积约2 cm×2 cm,右脚各脚趾可见烧灼样改变,大脚趾破溃,左脚水肿。
外伤后误诊误治医疗事故争议三例分析
Authors: 陈新山, 臧焰
Journal: BMJ (2005)

外伤后误诊误治医疗纠纷,是指患者因外力致身体损伤而接受医疗诊治后发生的一类医疗事故争议.这种既有外伤又有诊治失误的医疗事故争议是医疗纠纷的一个重要类型,也是法医学鉴定、医疗事故鉴定及其调处或审判的一大难点和重点.现报告3例,供参考。
Effect of rectal diclofenac on incidence of hyperamylasemia and hyperlipasemia after double-balloon enteroscopy
Authors: Xinyue Wan, Tao Deng
Journal: BMJ (2015)

To evaluate the efficacy of the prophylactic use of diclofenac in prevention of hyperamylasemia and hyperlipasemia in patients undergoing double-balloon enteroscopy (DBE). One hundred and sixteen patients undergoing peroral DBE were enrolled in the study. Total 121 procedures were performed, in 56 procedures diclofenac sodium 50 mg was administered by rectum 1 h before the peroral DBE (intervention group) and in 65 procedures no medication was given (control group). Serum amylase and lipase levels were measured before and 4 h, 24 h after the procedure.At 4 h after DBE the incidence rates of hyperamylasemia and hyperlipasemia in intervention and control groups were 33.9%, 38.5% (P>0.05) and 21.4%, 36.9% (P>0.05), respectively. At 24 h after DBE, the incidence rates of hyperamylasemia and hyperlipasemia in intervention and control groups were 19.6%, 24.6% (P>0.05) and 10.7%, 15.4% (P>0.05), respectively. Mild acute pancreatitis developed in one patient and gastrointestinal hemorrhage occurred in another patient.Hyperamylasemia and hyperlipasemia is common and transient after double-balloon enteroscopy, and rectal administration of diclofenac sodium cannot effectively reduce the incidence.


Key words: 
Hyperamylasemia; Lipase; Double-balloon enteroscopy
Clinical efficacy and molecular effects of lenvatinib (Len) and letrozole (Let) in hormone receptor-positive (HR+) metastatic breast cancer (MBC).
Authors: Joline Si Jing Lim, Andrea Wong, Samuel Guan Wei Ow, Natalie Ngoi, Yvonne Li'en Ang, Gloria Chan, Lim Siew Eng, Wan Qin Chong, Joan Choo, Matilda Lee, Hon Lyn Tan, Yi-hua Jan, Kien Thiam Tan, Raghav Sundar, David Shao Peng Tan, Ross A. Soo, Cheng Ean Chee, Wei-Peng Yong, Boon C. Goh, Soo-Chin Lee
Journal: Journal of Clinical Oncology (2020)

1019 Background: Preclinical studies show cross talk between RET and estrogen receptor, with at least additive treatment (Tx) effect of Len, a RET inhibitor, with Let. Our previous work concluded a recommended phase 2 dose (RP2D) of Len 14mg daily and Let 2.5mg daily (Lim, ASCO 2019). We present efficacy data from dose escalation and expansion cohorts. Methods: Safety, tolerability and efficacy data of MBC patients in both dose escalation (Len dose level 1 [DL]:20mg, DL -1:16mg and DL -2:14mg) and expansion (Len 14mg) cohort of this phase Ib/II study of combination Len+Let study was analysed. Patients were treated with single-agent Len for 2 weeks, followed by Len+Let until disease progression (PD). Serial tumor biopsies at baseline, after Len alone, 4 weeks post Len+Let, and upon PD, were sequenced for 440 genes with the ACTOnco+ platform. Results: A total of 33 pts (DL1 6pts, DL-1 6pts, DL-2 + expansion 21pts) with median 5 lines of prior Tx (range 0-11) were enrolled; 87.9%, 75.8%, and 75.8% had prior endocrine therapy (ET), ET+CDK4/6 inhibitor (i), and chemotherapy (CT) respectively. Objective response rate (ORR), disease control rate (DCR) ≥6 months (m), median duration of response (DOR), and percentage progression-free (PPF) at 12m were 33.3%, 45.5%, 11.5m (range 6.3-22.4), and 27.2% respectively. Among patients who previously progressed on CDK4/6i (n = 25), ORR, DCR ≥6m, median DOR, and PPF at 12m were 24.0%, 40.0%, 13.7m (range 6.3-18.2), and 12.0% respectively. Of note, 3/25 (12%) patients had durable response to Len+Let lasting ≥12m, despite having only modest PFS on ET+CDK4/6i (3, 7, and 12 months respectively). Most frequent all-grade toxicities (tox) were HTN (n = 15, G3:15), hypothyroidism (n = 20, G3:0) and fatigue (n = 13, G3:2), with no G4/5 tox. No new toxicity signals were observed compared to dose escalation phase. Pre-treatment tumor molecular profiling showed responders to be more likely to harbor NEFH, USH2A and PTCH1 mutations, while non-responders were more likely to carry PIK3R1, APC and PALB2 mutations. Sequencing of serial biopsies showed downregulation of BRD4, PTCH1, KIT, NTRK1 and CREBBP after Len treatment. Conclusions: Len+Let showed significant anti-tumor activity with meaningful duration of response, even in pts who failed prior CT or ET+CDK4/6i. The results support further investigation in randomized studies. Tumor profiling identified mutations associated with response and insights on molecular effects of lenvatinib. Clinical trial information: NCT02562118 .
由病例分析看类风湿关节炎关节外表现的诊断与治疗
Authors: 徐东
Journal: BMJ (2006)

类风湿关节炎(rheumatoild arthritis,RA)是一种病因不明的全身性自身免疫性疾病,主要表现为对称性、慢性、进行性多关节炎,关节外表现也不少见.一般RA的关节病变只能致残,罕见致死,但关节外表现或其并发症则有致死的可能.全面了解RA的关节外表现,才能尽量避免误诊,做到早期治疗,改善预后。
POF (paclitaxel/oxaliplatin/5-FU/leucovorin) versus SOX/CAPOX/FOLFOX as a postoperative adjuvant chemotherapy for curatively resected stage III gastric cancer: Study protocol for a randomized controlled trial, FNF-014 trial.
Authors: Liyu Su, Chunxiang Li, Feng Huang, Lu chuan Chen, Lisheng Cai, Jiayi Li, Shen Zhao, Rongbo Lin
Journal: Journal of Clinical Oncology (2020)

TPS4647 Background: Postoperative chemotherapy (S-1, CAPOX, or Docetaxel/S-1) is a standard treatment for stage II/III gastric cancer in Asia. With regard to single agent or doublet, the need for improvement has consistently been pointed out because of the relatively poor outcome for patients with stage III gastric cancer. Triplet (FLOT) has shown significant survival benefits in perioperative setting. POF, our regiment similar to FLOT, demonstrated priority to doublet (FOLFOX) in advanced setting (2019 ASCO-GI). We conducted a randomized, multicenter, phase III study to compare triplet to doublet regimens for patients with stage III gastric cancer. Methods: This is currently enrolling patients (n = 544) with pathologic stage III gastric cancer after D2 lymph node dissection. Patients are randomized 1:1 and stratified by tumor stage (IIIA, IIIB, or IIIC, AJCC 8th) into POF or SOX/CAPOX/FOLFOX (chosen by the clinicians). SOX: oxaliplatin 130 mg/m2 on day 1, oral S-1 80mg/m2 divided by two on days 1 to 14 every 21 days for 8 cycles. CAPOX: oxaliplatin 130 mg/m2 on day 1, oral capecitabine 1000 mg/m2 twice daily on days 1 to 14 every 21 days for 8 cycles. FOLFOX: oxaliplatin 85 mg/m2, levo-leucovorin 200 mg/m2, and 5-FU 400 mg/m2 bolus on day 1, then 5-FU 2400 mg/m2 continuous infusion over 46 hours, every 14 days for 12 cycles. Three doublets were chosen by the clinicians. POF: paclitaxel 135 mg/m2, followed by FOLFOX omitted 5-FU bolus, every 14 days for 12 cycles. Eligibility criteria: patients aged 18-70 years, primary histologically proven gastric adenocarcinoma (including adenocarcinoma of the gastroesophageal junction) of stage III with no evidence of metastatic disease, R0 resection with D2 lymph node dissection, good performance status (ECOG PS ≤1). Subjects must be able to take orally, and without other concomitant medical conditions that required treatment, initially treated with curative surgery followed by chemotherapy within 42 days. Life expectancy estimated more than 6 months. Adequate organ function. All patients provided written informed consent prior to treatment. Key exclusion criteria: patients with other primary malignancies, gastrointestinal bleeding. The primary end point is 3-year disease-free survival. Secondary end points are 3-year overall survival, 5-year overall survival, 5-year disease-free survival, and adverse events. Clinical trial information: NCT03788226 .
Analysis on risk factors of microvascular complications in type 2 diabetes mellitus based on classification tree model
Authors: Jieqiong Lou, Rong Shi, Lili Jia, Shengbing Zhang, Daoping Song, Yun Peng, Ming Cui, Hui Zhang, Qinkang Jiang, Yi Feng, Hui Yang, Fei Qin, Wen Long
Journal: BMJ (2017)

Objective
To analyze the risk factors of microvascular complications in patients with type 2 diabetes mellitus (T2DM).


Methods
The demographic and clinical data of 5 078 T2DM patients in six communities of Shanghai were collected during September 2014 to April 2015. The risk factors of microvascular complications in T2DM were analyzed by classification tree model.


Results
Among 5 078 T2DM patients there were 1 007 cases of diabetic retinopathy (DR) (21.1%) and 1 937 cases of diabetic nephropathy (DN) (38.4%). The classification tree models showed that the risk factors of DR were higher hemoglobin A1C (HbA1c), fasting blood glucose (FBG), postprandial blood glucose (PBG) and triacylglycerol (TG) levels; longer course of disease and younger age of onset. The model showed that the risk factors of DN were higher HbA1c, FBG, hypertension, PBG, body mass index (BMI) and triacylglycerol (TG) levels; and lower high-density lipoprotein (HDL) level. The HbA1c, course of disease and PBG were more closely related to DR and HbA1c, hypertension and FBG were more closely related to DN.


Conclusion
HbA1c is the most important risk factor to microvascular complications; FBG and PBG are independent risk factors of microvascular complications; the course of disease and hypertension are risk factors of DR and DN, respectively.


Key words: 
Diabetes mellitus, type 2; Microvascular complications; Risk factors
Demands and needs of patients signing family doctor service in Nanjing Gulou district
Authors: Ronghua Wang, Yuntao Li, Xiaomin Zhao, Jinyan Wang, Jinhui An, Yaoqi Ge
Journal: BMJ (2018)

Objective
To investigate the demands and needs of patients contracting for family doctor service in Nanjing Gulou district.


Methods
A questionnaire survey was conducted between July and December 2017 among residents in Nanjing Gulou district. The questionnaire included basic information of residents, willingness to sign service contract with family doctors, annual outpatient needs, demands of service mode, expectation for family doctor service, and willingness to pay.


Results
A total of 420 questionnaires were distributed and 415 questionnaires were valid. Multivariate analysis of variance suggested that age, income, and understanding of signing family doctor service were independent factors influencing signing intention (P<0.05).The variance analysis trend test indicated that the healthy people had highest willingness of signing, followed by the patients and the pregnant women (F=6.82, P<0.01). The number of annual outpatient service needs for healthy population, hypertensive patients, diabetic patients and pregnant women was (2.64±3.48) , (7.02±4.80) , (9.98±5.37) and (11.20±4.33) respectively (F=77.94, P<0.01). The average need of outpatient visit for health males was higher than that for females (P<0.01). There were significant differences in outpatient needs between patients with non-complicated hypertension and complicated hypertension (P<0.01). The most anticipated services for healthy people were health records (74.26%, 101/136), medical appointments (56.62%,77/136), and physical check-up (56.62%,77/136); those were management of blood glucose, blood pressure and body weight (70.13%, 108/154), regular testing (66.88%,103/154), follow-up supervision (66.23%,102/154) for chronic patients; those were regular physical examination (80.26%,61/76), follow-up supervision (50.00%,38/76) and health records (46.05%,35/76) for pregnant women. The most popular health communication channel is WeChat, accounting for 44.10% (183/415) , followed by outpatient clinic, telephone and internet services, accounting for 37.11% (154/415) , 31.57% (131/415) and 11.08% (46/415) respectively. Among those who chose WeChat, 81.4% (149/183) were under 45 years old. And 86.27% (358/415) of people were willing to pay for corresponding signing fees.


Conclusion
Age, income, and understanding of general practice will affect residents′ willingness to sign the service contract with family doctors. Gender, disease spectrum and number of illnesses affect residents′ outpatient service needs. Individualized family doctor service should be provided for people with different health needs.


Key words: 
Family doctor; Health management; Signing service
云南白药联合食醋外敷治疗接种全细胞百白破疫苗致红肿硬结的临床观察
Authors: 石蕾
Journal: BMJ (2011)

从2008年9月1日开始,我中心公共卫生科对3月龄以上小儿接种免费的全细胞百白破疫苗.接种疫苗后出现的不良反应主要为局部红肿硬结.对此,我科对2008年9月至2010年6月接种全细胞百白破疫苗致红肿硬结的54例患儿应用云南白药+食醋外敷治疗,取得较满意效果。
The diagnostic value of fibro-optic bronchoscopy examination combined with detection of aberrant p16 promoter methylation in lung cancer
Authors: Zhuo-jun Hu, Da-ying Liu, Yi-ping Chen, Jin-ping Chen, Hong-chun Tan, Jin-gang Zhou, Hai-liang Liu, Yan Zhong
Journal: BMJ (2010)

Fibro-optic bronchoscopy (FB) examinations were undertaken in 42 cases with lung cancer and 25 cases with benign lung disease; methylation-specific PCR was performed in plasma, sputum and bronchoalveolar lavage fluid (BALF) specimen for detection of p16 gene promoter methylation in all patients.Of the 42 cases of lung cancer, the positive rates of p16 gene promoter methylation were 59.5% in BALF, 52.4% in plasma and 47.6% in sputum, respectively; while p16 gene promoter methylation was detected only in one plasma sample from 25 cases with benign lung disease ( P ＜ 0.05 ).The sensitivity,specificity and overall accuracy of FB were 59.5%, 100.0% and 74.6%, respectively.The sensitivity,specificity and overall accuracy of FB combined with aberrant p16 gene methylation in diagnosis of lung cancer were 92.9%, 96.2% and 94.0%, respectively.The FB examinations combined with detection of aberrant p16 gene methylation can further improve the accuracy to diagnosis of lung cancer.

Key words: 
Bronchoscope;  Gene,p16
面部寻常狼疮一例
Authors: 姚树成, 郝继, 高岩, 王海艳, 张旭焱, 林琦
Journal: BMJ (2007)

患者男,42岁,牧民.因右面颊部乳头状增生性结节3年就诊.患者于3年前无明显原因右面颊部出现针帽大小红棕色结节,表面无渗出,无痒痛,质柔软.在当地多家医院就诊,先后诊断为毛囊炎、面部真菌感染、盘状红斑狼疮等.给予化毒丸、莫匹罗星软膏、伊曲康唑胶囊、复方曲安奈德乳膏、昆明山海棠、羟氯喹等治疗,皮损不见好转,且逐渐增多增大.于2004年11月11日就诊于我院皮肤性病科.病程中无发热、盗汗、乏力、消瘦.患者既往健康,否认肝炎、结核等传染病史,无药物过敏史,家中无类似病史。