tbuckley/cabot-search huggingface dataset:
Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia
Authors: Alison M. Taylor, Elizabeth R. Macari, Iris T. Chan, Megan C. Blair, Sergei Doulatov, Linda T. Vo, David M. Raiser, Kavitha Siva, Anindita Basak, Mehdi Pirouz, Arish N. Shah, Katherine McGrath, Jessica M. Humphries, Emma Stillman, Blanche P. Alter, Eliezer Calo, Richard I. Gregory, Vijay G. Sankaran, Johan Flygare, Benjamin L. Ebert, Yi Zhou, George Q. Daley, Leonard I. Zon
Journal: Science Translational Medicine (2020)

Calmodulin inhibitors rescue erythropoiesis and p53-dependent phenotypes of Diamond-Blackfan anemia.
Thalidomide and Dexamethasone Maintenance after Autologous Stem Cell Transplantation in Newly Diagnosed Korean Multiple Myeloma Patients: A Prospective Multi-Center Study in Asia
Authors: Sang-A Kim, Sung-Soo Yoon, Youngil Koh, Dong-Yeop Shin, Jin Seok Kim, Kihyun Kim, Chang-Ki Min, Hyeon-Seok Eom, Je-Jung Lee, Jeong-Ok Lee, Soo-Mee Bang
Journal: Blood (2017)
Understanding chronic ankle instability: model rich, data poor
Authors: Chris Bleakley, Jente Wagemans, Fredh Netterström-Wedin
Journal: British Journal of Sports Medicine (2020)

Ankle sprains are common sports injuries. Although often perceived as innocuous, large proportions of patients develop a cluster of persistent symptoms, termed chronic ankle instability (CAI). In 1965, Freeman1 first described a clinical paradox whereby poor recovery after ankle sprain (characterised by feelings of ‘giving way’) was reported in both the presence and absence of mechanical instability (MI). Since then, researchers have tried to explain this anomaly using original research, theoretical frameworks and multicomponent aetiological models for CAI. In this editorial, we discuss perennial and fundamental shortcomings in the evidence base, that continue to limit our understanding of CAI causation.

Most original research examining CAI aetiology is case-controlled. While this is both practical and cost-saving, its data can only ‘explain’ CAI aetiology after the fact. Few studies have prospectively tracked recovery post ankle sprain,2 3 with even fewer prognostic factors emerging. As a result, the content of aetiological models in this field1 4 5 is either theoretical or driven primarily by cross-sectional data. An inevitable consequence is an ever-increasing …
Type 2 Diabetes and COVID-19–Related Mortality in the Critical Care Setting: A National Cohort Study in England, March–July 2020
Authors: John M. Dennis, Bilal A. Mateen, Raphael Sonabend, Nicholas J. Thomas, Kashyap A. Patel, Andrew T. Hattersley, Spiros Denaxas, Andrew P. McGovern, Sebastian J. Vollmer
Journal: Diabetes Care (2020)

OBJECTIVE To describe the relationship between type 2 diabetes and all-cause mortality among adults with coronavirus disease 2019 (COVID-19) in the critical care setting. RESEARCH DESIGN AND METHODS This was a nationwide retrospective cohort study in people admitted to hospital in England with COVID-19 requiring admission to a high dependency unit (HDU) or intensive care unit (ICU) between 1 March 2020 and 27 July 2020. Cox proportional hazards models were used to estimate 30-day in-hospital all-cause mortality associated with type 2 diabetes, with adjustment for age, sex, ethnicity, obesity, and other major comorbidities (chronic respiratory disease, asthma, chronic heart disease, hypertension, immunosuppression, chronic neurological disease, chronic renal disease, and chronic liver disease). RESULTS A total of 19,256 COVID-19–related HDU and ICU admissions were included in the primary analysis, including 13,809 HDU (mean age 70 years) and 5,447 ICU (mean age 58 years) admissions. Of those admitted, 3,524 (18.3%) had type 2 diabetes and 5,077 (26.4%) died during the study period. Patients with type 2 diabetes were at increased risk of death (adjusted hazard ratio [aHR] 1.23 [95% CI 1.14, 1.32]), and this result was consistent in HDU and ICU subsets. The relative mortality risk associated with type 2 diabetes decreased with higher age (age 18–49 years aHR 1.50 [95% CI 1.05, 2.15], age 50–64 years 1.29 [1.10, 1.51], and age ≥65 years 1.18 [1.09, 1.29]; P value for age–type 2 diabetes interaction = 0.002). CONCLUSIONS Type 2 diabetes may be an independent prognostic factor for survival in people with severe COVID-19 requiring critical care treatment, and in this setting the risk increase associated with type 2 diabetes is greatest in younger people.
TCT CONNECT-303 Patient Perspectives on Left Main Stem Revascularization Strategies: The OPINION-2 Study
Authors: Rutger Nuis, Adeel Jadoon, Bas van Dalen, Karolijn Dulfer, Kaneshka Masdjedi, Wijnand Den Dekker, Roberto Diletti, Jeroen Wilschut, Joost Daemen, Mattie Lenzen, Felix Zijlstra, Pieter Smits, Nicolas Van Mieghem
Journal: Journal of the American College of Cardiology (2020)
TCT CONNECT-386 Diabetes Mellitus Is Associated With Increased Risk of Early Stent-Related Complications in Patients Undergoing Drug-Eluting Stent Implantation: Insight From the Victorian Cardiac Outcomes Registry (VCOR)
Authors: Jason Nogic, Nitesh Nerlekar, Kean Soon, George Proimos, Melanie Freeman, Louise Roberts, Diem Dinh, Angela Brennan, Jennifer Cooke, Stephen Nicholls, Adam Brown
Journal: Journal of the American College of Cardiology (2020)
TCT CONNECT-407 Optical Coherence Tomography Influences Procedure and Vessel Preparation Decisions During Percutaneous Coronary Intervention: Insights From the LightLab Initiative
Authors: Kevin Croce, Hiram Bezerra, Jana Buccola, Richard Rapoza, Nick West, John Lopez, Brian Bergmark, Jason Wollmuth
Journal: Journal of the American College of Cardiology (2020)
TCT CONNECT-474 Incidence and Impact of Prosthesis–Patient Mismatch after Aortic Valve Replacement in the PARTNER 2 Trial and Registry
Authors: Julien Ternacle, Philippe Pibarot, Howard Herrmann, Susheel Kodali, Jonathon Leipsic, Philipp Blanke, Wael Jaber, Michael Mack, Marie-Annick Clavel, Erwan Salaun, Mathieu Bernier, Jonathan Beaudoin, Omar Khalique, Neil Weissman, Pamela Douglas, Jeroen Bax, Abdellaziz Dahou, Ke Xu, Maria Alu, Erin Rogers, Martin Leon, Vinod Thourani, Amr Abbas, Rebecca Hahn
Journal: Journal of the American College of Cardiology (2020)
Training in Surgery
Authors: Antonio V. Sterpetti
Journal: JAMA Surgery (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis
Authors: Antje Mohs, Tobias Otto, Kai Markus Schneider, Mona Peltzer, Mark Boekschoten, Christian H. Holland, Christian A. Hudert, Laura Kalveram, Susanna Wiegand, Julio Saez-Rodriguez, Thomas Longerich, Jan G. Hengstler, Christian Trautwein
Journal: Journal of Hepatology (2020)
TCT CONNECT-494 Importance of Symptom and Activity Improvement for Patients With Tricuspid Regurgitation (TR)
Authors: Ellen Janssen, Shannon Murphy, Melissa Mancilla, Sarah Mollenkopf, Patrick Verta, Ted Feldman, Charles Davidson, Mackram Eleid, Robert Kipperman, Robert Smith, Scott Lim, Firas Zahr, William Gray, Adam Greenbaum, Martin Leon, Susheel Kodali
Journal: Journal of the American College of Cardiology (2020)
Response to Comment on Kwon et al. The Long-term Effects of Metformin on Patients With Type 2 Diabetic Kidney Disease. Diabetes Care 2020;43:948–955
Authors: Soie Kwon, Clara Tammy Kim, Jung Pyo Lee
Journal: Diabetes Care (2020)

We appreciate the comments by Fu and van Diepen (1) on our recent study (2) about the advantage of metformin use in patients with advanced chronic kidney disease in terms of decreasing the risk of all-cause mortality and incident end-stage renal disease. As metformin users had better baseline characteristics than nonmetformin users, we used propensity score matching for covariate balancing.

Due to the limitations of randomized controlled trials, such as extensive resource requirements and difficulties in long-term follow-up, and introduction of electronic health record system, many observational studies based on real-world data have been conducted recently (3). The prevalence of diabetic kidney disease, one of the microvascular complications, increases …
TCT CONNECT-34 Efficacy and Safety of Impella Versus Intra-Aortic Balloon Pump in Acute Myocardial Infarction Complicated With Cardiogenic Shock: A Meta-Analysis
Authors: Abdelmoniem Moustafa, Mohammad Saud Khan, Marwan Saad, Ehab Eltahawy
Journal: Journal of the American College of Cardiology (2020)
TCT CONNECT-40 Ultrathin Bioresorbable Polymer Sirolimus-Eluting Stents Versus Thin Durable Polymer Everolimus-Eluting Stents in Patients Undergoing Coronary Revascularization (BIOFLOW V): 3-Year Results of the Acute Coronary Syndrome Subgroup Analysis
Authors: David Kandzari, Gheorghe Doros, Hector Garcia-Garcia, Johan Bennett, Elie Gharib, Ron Waksman
Journal: Journal of the American College of Cardiology (2020)
Faecal microbiota transplantation halts progression of human new-onset type 1 diabetes in a randomised controlled trial
Authors: Pieter de Groot, Tanja Nikolic, Silvia Pellegrini, Valeria Sordi, Sultan Imangaliyev, Elena Rampanelli, Nordin Hanssen, Ilias Attaye, Guido Bakker, Gaby Duinkerken, Antoinette Joosten, Andrei Prodan, Evgeni Levin, Han Levels, Bartjan Potter van Loon, Arianne van Bon, Catherina Brouwer, Sytze van Dam, Suat Simsek, Daniel van Raalte, Frank Stam, Victor Gerdes, Roel Hoogma, Martin Diekman, Martin Gerding, Cees Rustemeijer, Bernadette de Bakker, Joost Hoekstra, Aeilko Zwinderman, Jacques Bergman, Frits Holleman, Lorenzo Piemonti, Willem De Vos, Bart Roep, Max Nieuwdorp
Journal: Gut (2020)

Objective Type 1 diabetes (T1D) is characterised by islet autoimmunity and beta cell destruction. A gut microbiota–immunological interplay is involved in the pathophysiology of T1D. We studied microbiota-mediated effects on disease progression in patients with type 1 diabetes using faecal microbiota transplantation (FMT). Design Patients with recent-onset (&lt;6 weeks) T1D (18–30 years of age) were randomised into two groups to receive three autologous or allogenic (healthy donor) FMTs over a period of 4 months. Our primary endpoint was preservation of stimulated C peptide release assessed by mixed-meal tests during 12 months. Secondary outcome parameters were changes in glycaemic control, fasting plasma metabolites, T cell autoimmunity, small intestinal gene expression profile and intestinal microbiota composition. Results Stimulated C peptide levels were significantly preserved in the autologous FMT group (n=10 subjects) compared with healthy donor FMT group (n=10 subjects) at 12 months. Small intestinal Prevotella was inversely related to residual beta cell function (r=−0.55, p=0.02), whereas plasma metabolites 1-arachidonoyl-GPC and 1-myristoyl-2-arachidonoyl-GPC levels linearly correlated with residual beta cell preservation (rho=0.56, p=0.01 and rho=0.46, p=0.042, respectively). Finally, baseline CD4 +CXCR3+T cell counts, levels of small intestinal Desulfovibrio piger and CCL22 and CCL5 gene expression in duodenal biopsies predicted preserved beta cell function following FMT irrespective of donor characteristics. Conclusion FMT halts decline in endogenous insulin production in recently diagnosed patients with T1D in 12 months after disease onset. Several microbiota-derived plasma metabolites and bacterial strains were linked to preserved residual beta cell function. This study provides insight into the role of the intestinal gut microbiome in T1D. Trial registration number NTR3697.
TCT CONNECT-227 The Role of Neighborhood Disadvantage in Predicting Mortality in Patients After Transcatheter Aortic Valve Replacement
Authors: Jesse Goitia, Derek Phan, Ming-Sum Lee, Naing Moore, Prakash Mansukhani, Vicken Aharonian, Somjot Brar, Ray Zadegan
Journal: Journal of the American College of Cardiology (2020)
Oral lichen planus pathogenesis: A role for the HCV-specific cellular immune response
Authors: Massimo Pilli, Amalia Penna, Alessandro Zerbini, Paolo Vescovi, Maddalena Manfredi, Francesco Negro, Marco Carrozzo, Cristina Mori, Tiziana Giuberti, Carlo Ferrari, Gabriele Missale
Journal: Hepatology (2002)

Hepatitis C virus infection can be associated with different extrahepatic manifestations, including lichen planus; however, no clear role for HCV in their pathogenesis has been established. T cells were isolated from lichen biopsy specimens of 7 HCV positive patients with oral lichen planus. HCV-specific CD4 + T-cell lines were obtained in 4 patients from lichen lesions but only in 2 of them from the peripheral blood. Different clonal populations were found in oral tissue and peripheral blood of individual patients, as shown by TCR-Vβ analysis of antigen-specific T cells. Frequency of HCV-specific CD8 + cells tested with 4 different HCV tetramers was significantly higher in the lichen tissue than in the circulation; moreover, lichen-derived HCV-specific CD8 + T cells showed the phenotype of recently activated T cells because most of them were CD69 + and produced interferon gamma (IFN-γ) but expanded poorly in vitro upon antigen stimulation. The specificity of HCV-reactive T-cell recruitment into the lichen tissue was further confirmed by the absence of HBV-specific T cells within lichen lesions in 3 additional patients with lichen planus associated with HBV infection. Our study shows HCV-specific T-cell responses at the site of the lesions of an HCV-associated dermatologic disease, sustained by HCV-specific T cells with phenotypic and functional characteristics of terminally differentiated effector cells. In conclusion, this finding and the detection of HCV RNA strands in the lichen tissue strongly suggest a role for HCV-specific T-cell responses in the pathogenesis of oral lichen planus associated with HCV infection. (Hepatology2002;36:1446-1452).
Early emergence of T central memory precursors programs clonal dominance during chronic viral infection
Authors: Simon Grassmann, Lorenz Mihatsch, Jonas Mir, Atefeh Kazeroonian, Roza Rahimi, Sophie Flommersfeld, Kilian Schober, Inge Hensel, Justin Leube, Ludwig O. Pachmayr, Lorenz Kretschmer, Qin Zhang, Adrien Jolly, M. Zeeshan Chaudhry, Matthias Schiemann, Luka Cicin-Sain, Thomas Höfer, Dirk H. Busch, Michael Flossdorf, Veit R. Buchholz
Journal: Nature Immunology (2020)
Preparing democracies for pandemics
Authors: Thomas J Bollyky, Ilona Kickbusch
Journal: BMJ (2020)

The coronavirus pandemic is not an advertisement for the health effects of democracy.Several democracies-such as New Zealand, South Korea, Germany, and Uruguay-acted quickly to contain SARS-CoV-2, yet many others-including Brazil, India, the UK, and the US-struggled to respond.As of October 2020, nine of the 10 nations with the highest cumulative cases of covid-19 were democracies.
New advances in the diagnosis and management of hepatocellular carcinoma
Authors: Ju Dong Yang, Julie K Heimbach
Journal: BMJ (2020)

ABSTRACT Hepatocellular carcinoma is one of the leading causes of cancer related death in the world. Biannual surveillance for the disease in patients with cirrhosis and in high risk carriers of hepatitis B virus allows early stage cancer detection and treatment with good long term outcomes. Liver ultrasonography and serum α fetoprotein are the most commonly used surveillance tests. If suspicious results are found on the surveillance test, multiphasic computed tomography or magnetic resonance imaging should be undertaken to confirm the diagnosis of hepatocellular carcinoma. If radiologic tests show inconclusive results, liver biopsy or repeat imaging could be considered for confirmation of hepatocellular carcinoma. Management of the disease is complex. Patients should be evaluated by a multidisciplinary team, and the selection of treatment should consider factors such as tumor burden, severity of liver dysfunction, medical comorbidities, local expertise, and preference of patients. Early stage hepatocellular carcinoma is best managed by curative treatment, which includes resection, ablation, or transplantation. Patients with intermediate stage disease often receive locoregional treatment. Systemic treatment is reserved for patients with advanced disease. Several positive, phase III, randomized controlled trials have expanded the systemic treatment options for advanced hepatocellular carcinoma with promising long term outcomes, especially trials using combination treatments, which could also have eventual implications for the treatment of earlier stage disease.
A Patient in Their 90s With Visible Precordial Pulsations
Authors: Charles W. Lanks, Janine Vintch
Journal: JAMA Cardiology (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
AB0915 BONE MINERAL DENSITY AND FRACTURE FREQUENCY IN PREMENOPAUSAL WOMEN WITH RHEUMATIC DISEASES
Authors: N. Toroptsova, O. Dobrovolskaya, O. Nikitinskaya, N. Demin, A. Smirnov, L. Shornikova
Journal: Annals of the Rheumatic Diseases (2020)

Background: The onset of the disease in young and middle age is typical for rheumatic diseases (RDS), but most studies on osteoporosis were conducted in patients (pts) older than 50 years, which included postmenopausal women. Objectives: To assess bone mineral density (BMD), fracture frequency and the factors associated with low BMD in premenopausal women with RDs. Methods: 160 women (median age, 36 [29; 43] years): 120 pts with RDs (43 rheumatoid arthritis (RA), 53 systemic sclerosis (SSc) and 24 psoriatic arthritis (PsA)) and 40 age-matched healthy controls were enrolled in the study. We performed a dual-energy X-ray absorptiometry (DXA, Hologic Discovery A, USA) to measure BMD in lumbar spine, femoral neck and total hip. BMD decreasing grade was evaluated by the Z-score &lt;-2SD. All pts were interviewed using a unified questionnaire including assessment of daily dietary calcium intake. Serum vitamin D, C-reactive protein and erythrocyte sedimentation rate (ESR) measurements were done. Results: 25% pts with RDs and only 8% healthy controls have low BMD (p=0.02). RA, SSc and PsA pts had low BMD in 37%, 21% and 13%, respectively, that was more often than in healthy women (p=0.004, p=0.046 and p= 0.081, respectively). 9,3% RA pts and 7,5% SSc pts had low energy fractures. BMD of RDs pts in all areas of measurement demonstrated a direct correlation with height, weight, body mass index, and serum vitamin D concentration and an inverse correlation with the cumulative dose of glucocorticoids. Also, proximal femur BMD inversely correlated with RDs duration. BMD of femoral neck and total hip inversely correlated with C-reactive protein level in SSc pts. In RA women we found a direct correlation between lumbar spine and femur neck BMD and ESR. Conclusion: 25% of premenopausal women with RDs had reduced BMD and needed monitoring and osteoporosis prevention, while 9.3% pts with RA and 7.5% women with SSc needed anti-osteoporotic treatment. Disclosure of Interests: None declared
TCT CONNECT-157 Off-Pump Versus On-Pump Repeat Coronary Artery Bypass Grafting: A Systematic Review and Meta-Analysis
Authors: Andreas Tzoumas, Stefanos Giannopoulos, Fotis Kakargias, Damianos Kokkinidis, George Giannakoulas, Robert Faillace, Christos Bakoyiannis, Ilias Doulamis, Dimitrios Avgerinos
Journal: Journal of the American College of Cardiology (2020)
Covid 19: Patients have many more complications than flu patients, finds US study
Authors: Janice Hopkins Tanne
Journal: BMJ (2020)

Patients who had been admitted to hospital with covid-19 had many more complications, and more serious ones, than patients with influenza, says a study from the US Veterans Health Administration.1 Patients with covid-19 were more likely than flu patients to need treatment in intensive care, had longer hospital stays, and were more likely to die.

“Certain racial and ethnic minority groups are disproportionately affected by covid-19 and … this discrepancy is not solely accounted for by age and underlying medical conditions,” the authors reported.

Until now data have been lacking to compare in-hospital complications of patients with covid-19 with patients with influenza, the …
Toll-like receptor 2-modulating pectin-polymers in alginate-based microcapsules attenuate immune responses and support islet-xenograft survival
Authors: Shuxian Hu, Rei Kuwabara, Carlos E. Navarro Chica, Alexandra M. Smink, Taco Koster, Juan D. Medina, Bart J. de Haan, Martin Beukema, Jonathan R.T. Lakey, Andrés J. García, Paul de Vos
Journal: Biomaterials (2020)

Encapsulation of pancreatic islets in alginate-microcapsules is used to reduce or avoid the application of life-long immunosuppression in preventing rejection. Long-term graft function, however, is limited due to varying degrees of host tissue responses against the capsules. Major graft-longevity limiting responses include inflammatory responses provoked by biomaterials and islet-derived danger-associated molecular patterns (DAMPs). This paper reports on a novel strategy for engineering alginate microcapsules presenting immunomodulatory polymer pectin with varying degrees of methyl-esterification (DM) to reduce these host tissue responses. DM18-pectin/alginate microcapsules show a significant decrease of DAMP-induced Toll-Like Receptor-2 mediated immune activation in vitro, and reduce peri-capsular fibrosis in vivo in mice compared to higher DM-pectin/alginate microcapsules and conventional alginate microcapsules. By testing efficacy of DM18-pectin/alginate microcapsules in vivo, we demonstrate that low-DM pectin support long-term survival of xenotransplanted rat islets in diabetic mice. This study provides a novel strategy to attenuate host responses by creating immunomodulatory capsule surfaces that attenuate activation of specific pro-inflammatory immune receptors locally at the transplantation site.