FRI0016 No relationships between acpa and periodontitis in early rheumatoid arthritis
Authors: F. Mechid, C. Zehraoui, M. Meddad, S. Salah, M. Benidir, S. Merad, N. Saidi, O. Cheikh, N. blidi, C. Dahou
Journal: Annals of the Rheumatic Diseases (2018)

<h3>Background</h3> Proteins citrullination contributes to generate anticitrullinated peptide antibodies (ACPA) in rheumatoid arthritis (RA). Porphyromonas gingivalis (Pg) is one of main germs incriminated in the development of periodontitis (PD), it has an enzyme called peptidyl arginine deiminase which is able to citrullinate the host proteins <h3>Objectives</h3> The aim of this study was to seek for a possible association between ACPA and periodontitis <h3>Methods</h3> We conducted a case-control study of 69 patients with early rheumatoid arthritis (≤2 years), naive of biotherapy and 138 age-and sex matched healthy controls. Smokers, diabetics, and subjects who received dental care and those who used antibiotics in the previous 6 months were not included. Demographic data and ACPA were determined. A periodontal examination was performed to all participants. Subgingival plaque samples were analysed to seek for Porphyromonas gingivalis(Pg) in both population in the case of periodontitis. <h3>Results</h3> The mean age of our patients was 40.75±12.04, the mean duration of the illness was 14.30±6.76 months (extremes: 1–24 months). ACPA was detected in 88% of patients and the mean titre was 255.57±409.78. PD frequency was higher in patient with PR compared with healthy controls (43% versus 29%) and a significant association was found between PR and PD (p&lt;10–3). Patients with RA had 2.46 (CI 1.12 to 5.39) higher odds of having PD compared with healthy controls. In early RA, ACPA titre and rate was not associated with PD (p=0.06,p=0.44 respectively). Regarding the frequency of Porphyromonas gingivalis, there was no significant difference between the PR group and the control group (p=0.45). In addition, there was no significant difference between RA group and controls (p=0.68) concerning Porphyromonas gingivalis and ACPA <h3>Conclusions</h3> Periodontitis is a risk factor for the occurrence of rheumatoid arthritis. The ACPA does not seem to be related to periodontitis. In addition there was no association between ACPA and the presence of porphyromonas gingivalis. <h3>References</h3> [1] Eriksson K, Nise L, Kats A, Luttropp E, Catrina AI, Askling J, Jansson L, Alfredsson L, Klareskog L, Lundberg K, Yucel-Lindberg T. Prevalence of Periodontitis in Patients with Established Rheumatoid Arthritis: A Swedish Population Based Case-Control Study. PLoS One2016;11(5):e0155956. [2] Laugisch O, Wong A, Sroka A, Kantyka T, Koziel J, Neuhaus K, Sculean A, Venables PJ, Potempa J, Möller B, Eick S. Citrullination in the periodontium -a possible link between periodontitis and rheumatoid arthritis. Clin Oral Investig2016;20(4):675–683. [3] Dissick A, Redman RS, Jones M, Rangan BV, Reimold A, Griffiths GR, et al. Association of Periodontitis with Rheumatoid Arthritis: A Pilot Study. Journal of Periodontology2010;81:223–230. [4] Mikuls TR, Payne JB, Yu F, et al. Periodontitis and porphyromonas gingivalis in patients with rheumatoid arthritis. Arthritis &amp; Rheumatology2014;66(5):1090–100. <h3>Disclosure of Interest</h3> None declared